Powered by Deep Web Technologies
Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Effects of prenatal exposure to ionizing radiation  

SciTech Connect

Prenatal exposure to ionizing radiation induces some effects that are seen at birth and others that cannot be detected until later in life. Data from A-bomb survivors in Hiroshima and Nagasaki show a diminished number of births after exposure under 4 wk of gestational age. Although a wide array of congenital malformations has been found in animal experimentation after such exposure to x rays, in humans only small head size (exposure at 4-17 wk) and mental retardation (exposure primarily at 8-15 wk) have been observed. In Hiroshima, small head size occurred after doses of 0.10-0.19 Gy or more, and an excess of mental retardation at 0.2-0.4 Gy or more. Intelligence test scores were reduced among A-bomb survivors exposed at 8-15 wk of gestational age by 21-29 IQ points per Gy. Other effects of in-utero exposure to atomic radiation include long-lasting complex chromosome abnormalities.

Miller, R.W. (National Cancer Institute, Bethesda, MD (USA))

1990-07-01T23:59:59.000Z

2

Ionizing Radiation  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Ionizing Radiation Measurements. Fees for services are located directly below the technical contacts ...

2013-04-09T23:59:59.000Z

3

Exposure to ionizing radiation in the emergency department from commonly performed portable radiographs  

SciTech Connect

To accurately assess the potential hazard of exposure to ionizing radiation from portable radiographs taken in the emergency department, a study was performed to measure such radiation at different distances from the edge of an irradiated field during portable cervical-spine (pC-S), portable chest radiograph (pCXR), and portable anteroposterior-pelvis (pAP-pelvis) radiographs. For all three types of portable radiographs, radiation exposure is a function of distance from the beam. However, at 40 cm (15 inches) away from the beam during a pC-S or pCXR and at 160 cm (63 inches) from a pAP-pelvis film, exposure is minimal. At these distances one would need to be exposed to more than 1,200 such radiographs to equal background environmental ionizing radiation. Medical personnel should not have to leave a patient care area for fear of undue acute and chronic radiation exposure while portable radiographs are performed in the ED. By using protective garments and standing appropriate distances away from the patient, continuous patient care can be maintained while portable radiographs are taken in the ED.

Grazer, R.E.; Meislin, H.W.; Westerman, B.R.; Criss, E.A.

1987-04-01T23:59:59.000Z

4

POSITION STATEMENT DOCUMENTING IONIZING RADIATION EXPOSURE IN THE ELECTRONIC HEALTH RECORD  

E-Print Network (OSTI)

IEEE-USA believes that maintaining an accurate record of a patient’s cumulative exposure to ionizing radiation can be of substantial value for clinical, health services management and research purposes. Excessive radiation can cause cancer, skin and bone marrow disease and a variety of other diseases. Radiation exposure can come from a number of sources, both natural and manmade. Over the lifetime of the individual, medical procedures, such as X-rays, Computed Tomography (CT) scans, and isotope radiation therapy, contribute significant radiation dosages. Monitoring the use of radiological procedures, measuring the radiation dose directly, and recording the dose in the Electronic Health Record (EHR) can help assess and reduce the risk posed by excessive radiation while optimizing the diagnostic value of these procedures. With these risks and benefits in mind, IEEE-USA recommends the following: 1. Health Level Seven International (HL7), the global authority responsible for standards for interoperability of health information technology, should add the appropriate "dose object " radiation parameters, as defined in the IHE Radiology Technical Framework Supplement, Radiation Exposure Monitoring (REM), to HL7/CDA format longitudinal electronic health records (EHRs), to create a longitudinal record of a patient's exposure to radiation resulting from medical procedures. These records should note both the procedure and estimated radiation dose from each procedure. 2. The Office of the National Coordinator for Health Information Technology (ONCHIT) should make radiation dose monitoring a part of meaningful use criteria for EHRs. 3. Healthcare accreditation organizations (JCAHO, NCQA and URAC), in collaboration with the American College of Radiologists (ACR), should continue

Adopted The Ieee-usa

2011-01-01T23:59:59.000Z

5

Ionizing Radiation Dosimetry  

Science Conference Proceedings (OSTI)

Ionizing Radiation Dosimetry. ... OH. US Air Force Radiation Dosimetry Laboratory, Wright-Patterson - Base, OH [100548- 0] PA. ...

2013-09-06T23:59:59.000Z

6

Lesson 4 - Ionizing Radiation | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4 - Ionizing Radiation 4 - Ionizing Radiation Lesson 4 - Ionizing Radiation Lesson Three showed that unstable isotopes emit energy as they become more stable. This energy is known as radiation. This lesson explores forms of radiation, where radiation is found, how we detect and measure radiation, what sources of radiation people are exposed to, whether radiation is harmful, and how we can limit our exposure. Specific topics covered in this lesson include: Types of radiation Non-ionizing Ionizing Forms of ionizing radiation Alpha particles Beta particles Gamma rays Radiation Decay chain Half-life Dose Radiation measurements Sources of radiation Average annual exposure Lesson 4 - Ionizing Radiation.pptx More Documents & Publications DOE-HDBK-1130-2008 DOE-HDBK-1130-2008 DOE-HDBK-1130-2007

7

Carcinogenesis and low-level ionizing radiation with special reference to lung cancer and exposure to radon daughters  

SciTech Connect

Of the important health effects of ionizing radiation, three important late effects - carcinogenesis, teratogenesis and mutagenesis are of greatest concern. This is because any exposure, even at low levels, carries some risk of such deleterious effects. As the dose of radiation increases above very low levels, the risk of health effects increases. Cancer-induction is the most important late somatic effect of low-dose ionizing radiation. Solid cancers, rather than leukemia, are principal late effects in exposed individuals. Tissues vary greatly in their susceptibility to radiation carcinogenesis. The most frequently occurring radiation-induced cancers in man include, in decreasing order of susceptibility: the female breast, the thyroid gland, the blood-forming tissues, the lung, certain organs of the gastrointestinal tract, and the bones. A number of biological and physical factors affect the cancer risk, such as age, sex, life-style, LET, and RBE. Despite uncertainty about low-level radiation risks, regulatory and advisory bodies must set standards for exposure, and individuals need information to be able to make informed judgments for themselves. From the point of view of the policy maker, the overriding concern is the fact that small doses of radiation can cause people to have more cancers than would otherwise be expected. While concern for all radiation effects exists, our human experience is limited to cancer-induction in exposed populations. This discussion is limited to cancer risk estimation and decision-making in relation to the health effects on populations of exposure to low levels of ionizing radiation. Here, low-level radiation will refer to yearly whole-body doses up to 5 rems or 0.05 Sv, or to cumulative doses up to 50 rems or 0.5 Sv from low-LET radiation and from high-LET radiation. (ERB)

Fabrikant, J.I.

1982-04-01T23:59:59.000Z

8

NVLAP Ionizing Radiation Dosimetry LAP  

Science Conference Proceedings (OSTI)

Ionizing Radiation Dosimetry LAP. ... This site has been established for applicants to the accreditation program for ionizing radiation dosimetry. ...

2013-07-23T23:59:59.000Z

9

NIST Ionizing Radiation Division - 2001  

Science Conference Proceedings (OSTI)

... The Ionizing Radiation Division of the Physics Laboratory supports the ... meaningful, and compatible measurements of ionizing radiations (x rays ...

10

Protection Against Ionizing Radiation in Extreme Radiation ...  

Science Conference Proceedings (OSTI)

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms. ... Elucidated radiation protection by intracellular halides. ...

2013-05-01T23:59:59.000Z

11

NIST Ionizing Radiation Division - 1998  

Science Conference Proceedings (OSTI)

TECHNICAL ACTIVITIES 1998 - NISTIR 6268 IONIZING RADIATION DIVISION. The Neutron Interferometer. The neutron ...

12

NIST Ionizing Radiation Division - 2000  

Science Conference Proceedings (OSTI)

"Technical Activities 2000" - Table of Contents, Division home page. Ionizing Radiation Division. ...

13

Ionizing radiation detector  

DOE Patents (OSTI)

An ionizing radiation detector is provided which is based on the principal of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

Thacker, L.H.

1989-06-08T23:59:59.000Z

14

Ionizing radiation detector  

DOE Patents (OSTI)

An ionizing radiation detector is provided which is based on the principle of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

Thacker, Louis H. (Knoxville, TN)

1990-01-01T23:59:59.000Z

15

NIST Ionizing Radiat. Div. - 2004: Strategic Focus 1  

Science Conference Proceedings (OSTI)

... and to determine exposure or dose-rate values ... to maximize the energy absorption of the ionizing radiation. ... the calibration of an 55 Fe low-energy x ...

16

Ionizing Radiation Division Quality Manual  

Science Conference Proceedings (OSTI)

... 08 47020C Low-energy Photon Brachytherapy Seeds, ... Calibrated for Surface Dose Rate 10 ... Sources Calibrated for Radiation Protection Ionization ...

2012-03-08T23:59:59.000Z

17

Epidemiology of accidental radiation exposures  

Science Conference Proceedings (OSTI)

Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental exposures and the types of studies that are needed. 64 refs., 3 tabs.

Cardis, E. [International Agency for Research on Cancer, Lyon (France)

1996-05-01T23:59:59.000Z

18

Cell Type-dependent Gene Transcription Profile in Three Dimensional Human Skin Tissue Model Exposed to Low Doses of Ionizing Radiation: Implications for Medical Exposures  

SciTech Connect

The concern over possible health risks from exposures to low doses of ionizing radiation has been driven largely by the increase in medical exposures, the routine implementation of X-ray backscatter devices for airport security screening, and, most recently, the nuclear incident in Japan. Due to a paucity of direct epidemiological data at very low doses, cancer risk must be estimated from high dose exposure scenarios. However, there is increasing evidence that low and high dose exposures result in different signaling events and may have different mechanisms of cancer induction. We have examined the radiation induced temporal response of an in vitro three dimensional (3D) human skin tissue model using microarray-based transcriptional profiling. Our data shows that exposure to 100 mGy of X-rays is sufficient to affect gene transcription. Cell type specific analysis showed significant changes in gene expression with the levels of > 1400 genes altered in the dermis and > 400 genes regulated in the epidermis. The two cell types rarely exhibited overlapping responses at the mRNA level. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) measurements validated the microarray data in both regulation direction and value. Key pathways identified relate to cell cycle regulation, immune responses, hypoxia, reactive oxygen signaling, and DNA damage repair. We discuss in particular the role of proliferation and emphasizing how the disregulation of cellular signaling in normal tissue may impact progression towards radiation induced secondary diseases.

Freiin von Neubeck, Claere H.; Shankaran, Harish; Karin, Norman J.; Kauer, Paula M.; Chrisler, William B.; Wang, Xihai; Robinson, Robert J.; Waters, Katrina M.; Tilton, Susan C.; Sowa, Marianne B.

2012-04-17T23:59:59.000Z

19

Ionizing Radiation Injury (South Carolina)  

Energy.gov (U.S. Department of Energy (DOE))

This legislation applies to employers that have more than one employee who engages in activities which involve the presence of ionizing radiation. Employers with less than three employees can...

20

Genome Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013  

SciTech Connect

During course of this project, we have worked in several areas relevant to low-dose ionizing radiation. Using gene expression to measure biological response, we have examined the response of human skin exposed in-vivo to radation, human skin exposed ex-vivo to radiation, and a human-skin model exposed to radiation. We have learned a great deal about the biological response of human skin to low-dose ionizing radiation.

Rocke, David M. [University of California Davis

2013-09-09T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation Oxidative Stress and Skeletal Health with Low Dose, Ionizing Radiation Globus Ruth NASA Ames Research Center Abstract Osteoporosis profoundly affects the aging U.S. population and exposure to high doses of radiation causes bone loss similar to age-related osteoporosis, although the influence of low dose radiation exposures is not known. The central hypothesis of our DOE project (NASA supplement) is that low doses of radiation modulate subsequent skeletal degeneration via oxidative pathways. Our working hypothesis is that a prior exposure to low dose radiation regulates oxidative metabolism within bone and contributes to bone loss caused either by subsequent high, challenge doses of radiation or by aging. HZE source: Because astronauts are exposed to radiation from GCR and solar

22

The ionizing radiation environment in space and its effects  

Science Conference Proceedings (OSTI)

The ionizing radiation environment in space poses a hazard for spacecraft and space crews. The hazardous components of this environment are reviewed and those which contribute to radiation hazards and effects identified. Avoiding the adverse effects of space radiation requires design, planning, monitoring and management. Radiation effects on spacecraft are avoided largely though spacecraft design. Managing radiation exposures of space crews involves not only protective spacecraft design and careful mission planning. Exposures must be managed in real time. The now-casting and forecasting needed to effectively manage crew exposures is presented. The techniques used and the space environment modeling needed to implement these techniques are discussed.

Adams, Jim; Falconer, David; Fry, Dan [Center for Space Plasma and Aeronomic Research (CSPAR), UA Huntsville (United States); Space Radiation Analysis Group, NASA Johnson Space Center (United States)

2012-11-20T23:59:59.000Z

23

Dosimetry for non-ionizing radiation  

SciTech Connect

Several commercially available phosphor-teflon dosimeters were subjected to thermal fade studies. The thermoluminescence dosimetry (TLD) tags were washed and air dried prior to each ionizing radiation pretreatment. Readings made over 3 weeks on the CaF2:Mn and CaF2:Dy TLD tags did not produce measurable thermal-fade characteristics for the 22 to 31/sup 0/C temperature range. Nonionizing radiation treatments were at 2.45 GHz. While the results obtained did demonstrate decreases in signal levels over time and temperature changes, the patterns were not smooth, making it impossible to establish differences in TLD readings as quantitative measures of temperature differences which could serve as measures of long-term exposures to nonionizing radiation. The authors concluded that, due to the irregularities that existed in the thermal fade characteristics, the dosimeter would not be suitable for quantifying exposures to nonionizing radiation. There was significant potential in the device, however, as an indicator of radiation leakage or exposure.

Fanslow, G.E.

1981-03-01T23:59:59.000Z

24

NIST Ionizing Radiation Division 2000 - Future Directions  

Science Conference Proceedings (OSTI)

... will enable dose-reconstruction studies for populations exposed at the natural background levels of ionizing radiation. Calibrations of Low-Energy ...

25

Radiation exposure in X-ray-based imaging techniques used in osteoporosis  

E-Print Network (OSTI)

to low levels of ionizing radiation: BEIR VII Phase 2. TheBlake G, Genant HK (1999) Radiation exposure in bone mineralGuglielmi Thomas M. Link Radiation exposure in X-ray-based

Damilakis, John; Adams, Judith E.; Guglielmi, Giuseppe; Link, Thomas M.

2010-01-01T23:59:59.000Z

26

Low dose diagnostic radiation exposure and cancer risk in Trp53...  

NLE Websites -- All DOE Office Websites (Extended Search)

University Abstract The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high...

27

Types of Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

External Irradiation Contamination Incorporation Biological Effects of Acute, Total Body Irradiation Managing Radiation Emergencies Procedure Demonstration Types of radiation...

28

THE HEALTH EFFECTS IN WOMEN EXPOSED TO LOW-LEVELS OF IONIZING RADIATION  

E-Print Network (OSTI)

and Effects of Ionizing Radiation. New York, United Nations,Effects of Ionizing Radiation (BEIR III). The EffectsLevels of Ionizing Radiation. Washington, D.C. , National

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

29

Ionization of Rydberg atoms by blackbody radiation  

E-Print Network (OSTI)

We have studied an ionization of alkali-metal Rydberg atoms by blackbody radiation (BBR). The results of the theoretical calculations of ionization rates of Li, Na, K, Rb and Cs Rydberg atoms are presented. Calculations have been performed for nS, nP and nD states which are commonly used in a variety of experiments, at principal quantum numbers n=8-65 and at the three ambient temperatures of 77, 300 and 600 K. A peculiarity of our calculations is that we take into account the contributions of BBR-induced redistribution of population between Rydberg states prior to photoionization and field ionization by extraction electric field pulses. The obtained results show that these phenomena affect both the magnitude of measured ionization rates and shapes of their dependences on n. A Cooper minimum for BBR-induced transitions between bound Rydberg states of Li has been found. The calculated ionization rates are compared with our earlier measurements of BBR-induced ionization rates of Na nS and nD Rydberg states with ...

Beterov, I I; Ryabtsev, I I; Entin, V M; Ekers, A; Bezuglov, N N

2008-01-01T23:59:59.000Z

30

Composite scintillators for detection of ionizing radiation  

DOE Patents (OSTI)

Applicant's present invention is a composite scintillator having enhanced transparency for detecting ionizing radiation comprising a material having optical transparency wherein said material comprises nano-sized objects having a size in at least one dimension that is less than the wavelength of light emitted by the composite scintillator wherein the composite scintillator is designed to have selected properties suitable for a particular application.

Dai, Sheng (Knoxville, TN); Stephan, Andrew Curtis (Knoxville, TN); Brown, Suree S. (Knoxville, TN); Wallace, Steven A. (Knoxville, TN); Rondinone, Adam J. (Knoxville, TN)

2010-12-28T23:59:59.000Z

31

Alloy nanoparticle synthesis using ionizing radiation  

DOE Patents (OSTI)

A method of forming stable nanoparticles comprising substantially uniform alloys of metals. A high dose of ionizing radiation is used to generate high concentrations of solvated electrons and optionally radical reducing species that rapidly reduce a mixture of metal ion source species to form alloy nanoparticles. The method can make uniform alloy nanoparticles from normally immiscible metals by overcoming the thermodynamic limitations that would preferentially produce core-shell nanoparticles.

Nenoff, Tina M. (Sandia Park, NM); Powers, Dana A. (Albuquerque, NM); Zhang, Zhenyuan (Durham, NC)

2011-08-16T23:59:59.000Z

32

Waveshifters and Scintillators for Ionizing Radiation Detection  

Science Conference Proceedings (OSTI)

Scintillation and waveshifter materials have been developed for the detection of ionizing radiation in an STTR program between Ludlum Measurements, Inc. and the University of Notre Dame. Several new waveshifter materials have been developed which are comparable in efficiency and faster in fluorescence decay than the standard material Y11 (K27) used in particle physics for several decades. Additionally, new scintillation materials useful for fiber tracking have been developed which have been compared to 3HF. Lastly, work was done on developing liquid scintillators and paint-on scintillators and waveshifters for high radiation environments.

B.Baumgaugh; J.Bishop; D.Karmgard; J.Marchant; M.McKenna; R.Ruchti; M.Vigneault; L.Hernandez; C.Hurlbut

2007-12-11T23:59:59.000Z

33

Molecular mechanisms and cellular consequences of low-dose exposure to ionizing  

NLE Websites -- All DOE Office Websites (Extended Search)

mechanisms and cellular consequences of low-dose exposure to ionizing mechanisms and cellular consequences of low-dose exposure to ionizing radiation Andrew J. Wyrobek 1 , Francesco Marchetti 1 , Xiu Lowe 1 , Xiaochen Lu 2 , Terumi Kohwi- Shigematsu 1 , Brian Davy 1 , Thomas E. Schmid 1 , Sylvia Ahn 1 , Tarlochan Nijjar 1 Matthew A. Coleman 2 , Contact information: ajwyrobek@gmail.com 1 Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 2 BioSciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA. The objectives of this research are to characterize the genome-wide molecular responses to low-dose ionizing radiation (<10cGy), to identify tissue and cell-type specific differences in pathways responses, and to identify the pivotal molecular pathway responses that control risks to genome integrity and health. This project utilizes mouse in

34

Concerns with low-level ionizing radiation  

SciTech Connect

Populations have been studied in geographic areas of increased natural radiation, in radiation-exposed workers, in patients medically exposed, and in accidental exposures. No reproducible evidence exists of harmful effects from increases in background radiation three to ten times the usual levels. There is no increase in leukemia or other cancers among American military participants in nuclear testing, no increase in leukemia or thyroid cancer among medical patients receiving {sup 131}I for diagnosis or treatment of hypothyroidism, and no increase in lung cancer among nonsmokers exposed to increased radon in the home. The association of radiation with the atomic bomb and with excessive regulatory and health physics as-low-as-reasonably-achievable (ALARA) radiation levels practices has created a climate of fear about the dangers of radiation at any level. However, there is no evidence that radiation exposures at the levels equivalent to medical usage are harmful. The unjustified excessive concern with radiation at any level, however, precludes beneficial uses of radiation and radioactivity in medicine, science, and industry.

Yalow, R.S.

1994-12-31T23:59:59.000Z

35

Low Dose Ionizing Radiation Modulates Immune Function New Project Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

Modulates Immune Function New Project Overview Modulates Immune Function New Project Overview Gregory Nelson Loma Linda University Abstract The immune system provides the first line of defense for exposures to environmental hazards. Protective immunity mechanisms using innate or adaptive responses are employed to mitigate acute challenges or amplify the readiness of the system to respond to future challenges. Some stimuli lead to amplified inflammatory reactions such as delayed hypersensitivity which is required for immunity to parasites and can also lead to adverse consequences such as contact dermatitis. Radiation exposure has the potential to aggravate hypersensitivity reactions as well as to suppress protective immunity. Ionizing radiation at high doses has long been recognized as highly effective in destroying cells of the immune system,

36

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells.  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells. Munira Kadhim 1 , Stefania Militi 1 , Debbie Bowler 1 , Denise Macdonald 1 and Kevin Prise 2 1 Radiation and Genome Stability Unit, MRC, Harwell, Didcot, Oxon, OX11 0RD, UK 2 Gray Cancer Institute ,PO Box 100, Mount Vernon Hospital, Northwood, HA6 2JR, UK Because the human population is genetically heterogeneous, it is important to understand the role that heterogeneity may play in radiation response. Exposure to ionizing radiation can lead to a suite of changes, including increased mutation rate, delayed reproductive cell death, and delayed chromosomal aberrations, all of which are manifestations of the complex genomic instability (GI) phenotype. Following exposure to either high LET

37

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic cells in zebrafish  

E-Print Network (OSTI)

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic of an adaptive response by the ionizing radiation against sub- sequent exposures to Cd. Keywords Multiple embryos subjected to a priming exposure provided by one environmental stressor (low-dose alpha particles

Yu, K.N.

38

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of the Current State of Radiation Protection Philosophy.Against Pergamon Ionizing Radiation from External Sources,for Protection Against Ionizing Radiation from Supplement to

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

39

Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse  

NLE Websites -- All DOE Office Websites (Extended Search)

Ionizing Radiation Alters the Epigenome of the A Ionizing Radiation Alters the Epigenome of the A vy Mouse Autumn Bernal 1,2,3 , Dale Huang 1 , Yue Li 4 , Dana Dolinoy 5 , and Randy Jirtle 1 Department of Radiation Oncology 1 , University Program in Genetics and Genomic 2 , Integrated Toxicology & Environmental Health Program 3 , Department of Community and Family Medicine 4 , Duke University Medical Center, Durham, NC, USA, Department of Environmental and Health Sciences, University of Michigan, Ann Arbor, MI, USA 4 Background: Humans have evolved and thrived amidst constant low-dose (0-10 cGy) background radiation exposure from natural sources. Currently, however, the frequency of exposures to low doses of radiation is increasing due to man-made sources such as diagnostic imaging and nuclear power. This increased exposure has led to concerns amongst the general public and the government about the

40

Identification of novel ionizing radiation signaling targets in reconstituted human skin  

NLE Websites -- All DOE Office Websites (Extended Search)

of novel ionizing radiation signaling targets in reconstituted human skin of novel ionizing radiation signaling targets in reconstituted human skin Feng Yang, Katrina M. Waters, Bobbie-Jo Webb-Robertson, Lye-Meng Markillie, Rachel M. Wirgau, Shawna M. Hengel, Ljiljana Pasa-Tolic, and David L. Stenoien. Pacific Northwest National Laboratory Our focus has been on identifying the early events that occur after low dose ionizing radiation exposure that precede and often regulate downstream events such as altered transcription, protein secretion and epigenetic regulation. Phosphorylation is one of the earliest detectible events that occurs following radiation exposure and plays important roles in multiple biological pathways including DNA damage repair, transcription, apoptosis, and cell cycle progression. Very robust

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

DNA damage produced by exposure of supercoiled plasmid DNA to high- and low-LET ionizing radiation: Effects of hydroxyl radical quenchers. DNA breakage, neutrons, OH radicals  

SciTech Connect

A supercoiled plasmid of 7300 base pairs was isolated and exposed in an aqueous environment to {sup 60}Co {gamma} rays and JANUS 0.85 MeV fission-spectrum neutrons. Dose responses for the production of single-strand breaks (SSBs), double-strand breaks (DSBs) and alkali-labile sites (ALSs) were compared with computations made from the conversion of the supercoil to its relaxed and linear forms. The relative biological effectiveness (RBE) for production of SSBs and DSBs was similar to that previously measured in the cellular environment. The RBE for destruction of genetic transforming activity of M13 viral DNA followed that for DNA damage. This is in contrast to the situation for biological effects such as lethality, mutagenesis, and cellular transformation measured in mammalian cells, where the RBE values are reversed. The role of hydroxyl (OH) radical in DNA damage induction by neutrons was investigated by exposure of plasmid in the presence of known quenchers of this species. Of four quenchers tested, all were able to reduce the yields of both SSBs and DSBs. These findings are consistent with a model for SSB and DSB induction by high linear energy transfer that involves OH radical mediation.

Peak, J.G.; Ito, T.; Peak, M.J. [Argonne National Lab., IL (United States); Robb, F.T. [Univ. of Maryland, Baltimore, MD (United States). Center for Marine Biotechnology

1994-08-01T23:59:59.000Z

42

22.01 Introduction to Ionizing Radiation, Fall 2003  

E-Print Network (OSTI)

Introduction to basic properties of ionizing radiations and their uses in medicine, industry, science, and environmental studies. Discusses natural and man-made radiation sources, energy deposition and dose calculations, ...

Coderre, Jeffrey A.

43

Ionizing radiation risks to satellite power systems (SPS) workers  

DOE Green Energy (OSTI)

The radiation risks to the health of workers who will construct and maintain solar power satellites in the space environment were examined. For ionizing radiation, the major concern will be late or delayed health effects, particularly the increased risk of radiation-induced cancer. The estimated lifetime risk for cancer is 0.8 to 5.0 excess deaths per 10,000 workers per rad of exposure. Thus, for example, in 10,000 workers who completed ten missions with an exposure of 40 rem per mission, 320 to 2000 additional deaths in excess of the 1640 deaths from normally occurring cancer, would be expected. These estimates would indicate a 20 to 120% increase in cancer deaths in the worker-population. The wide range in these estimates stems from the choice of the risk-projection model and the dose-response relationsip. The choice between a linear and a linear-quadratic dose-response model may alter the risk estimate by a factor of about two. The method of analysis (e.g., relative vs absolute risk model) can alter the risk estimate by an additional factor of three. Choosing different age and sex distributions can further change the estimate by another factor of up to three. The potential genetic consequences could be of significance, but at the present time, sufficient information on the age and sex distribution of the worker population is lacking for precise estimation of risk. The potential teratogenic consequences resulting from radiation are considered significant. Radiation exposure of a pregnant worker could result in developmental abnormalities.

Lyman, J.T.; Ainsworth, E.J.; Alpen, E.L.; Bond, V.; Curtis, S.B.; Fry, R.J.M.; Jackson, K.L.; Nachtwey, S.; Sondhaus, C.; Tobias, C.A.; Fabrikant, J.I.

1980-11-01T23:59:59.000Z

44

Low Dose Radiation Exposure: Exploring Bystander Effects In Vivo.  

NLE Websites -- All DOE Office Websites (Extended Search)

Exposure: Exploring Bystander Effects Exposure: Exploring Bystander Effects In Vivo. 1 Blyth, B.J., 1 Sykes, P.J. 1 Department of Haematology and Genetic Pathology, Flinders University and Medical Centre, Bedford Park, South Australia, 5042, The general population is daily exposed to chronic, low doses of ionizing radiation from both natural and artificial sources. The shape of the radiation dose-response curve at these low doses is currently linearly extrapolated from data obtained after high dose exposure due to the low sensitivity of traditional biological assays after near-background exposures. At odds with this Linear No-Threshold model, are the phenomena collectively referred to as the radiation-induced bystander effect. The bystander effect describes a collection of in vitro

45

Functional Proteomic Pattern Identification under Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

The goal of this study is to explore and to understand the dynamic responses of signaling pathways to low dose ionizing radiation (IR). Low dose radiation (10 cGy or lower) affects several signaling pathways including DNA repair, survival, cell cycle, ... Keywords: low dose radiation, functional proteomics

Young Bun Kim; Jean Gao; Ying Dong; Chin-Rang Yang

2008-11-01T23:59:59.000Z

46

2011 DOE Occupational Radiation Exposure Summary poster  

SciTech Connect

This poster graphically presents data pertaining to occupational radiation exposure in terms of total effective dose (TED), primarily, but also collective dose and average measureable dose.

ORAU

2012-12-12T23:59:59.000Z

47

Rules and Regulations for Control of Ionizing Radiation (Arkansas) |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Rules and Regulations for Control of Ionizing Radiation (Arkansas) Rules and Regulations for Control of Ionizing Radiation (Arkansas) Rules and Regulations for Control of Ionizing Radiation (Arkansas) < Back Eligibility Utility Program Info State Arkansas Program Type Environmental Regulations Siting and Permitting Provider Department of Health The Rules and Regulations for Control of Ionizing Radiation are the Arkansas state laws made in accordance the federal Nuclear Regulatory Commission Rules. Any contractor with the US DOE or US Nuclear Regulatory Commission is exempt from the state laws. This set of rules and regulations basically restates the federal policy to ensure that Arkansas is in compliance with the federal standards governing nuclear energy. Specifically the State rules are equivalent to Nuclear Regulatory

48

Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study  

Science Conference Proceedings (OSTI)

Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates, for example medical diagnostic procedures, may be overestimated by such risk models, but data for humans to examine this issue are limited. In this paper we report on lung cancer mortality between 1950 and 1987 in a cohort of 64,172 Canadian tuberculosis patients, of whom 39% were exposed to highly fractionated multiple chest fluoroscopies leading to a mean lung radiation dose of 1.02 Sv received at moderate dose rates. These data have been used to estimate the excess relative risk per sievert of lung cancer mortality, and this is compared directly to estimates derived from 75,991 atomic bomb survivors. Based on 1,178 lung cancer deaths in the fluoroscopy study, there was no evidence of any positive association between risk and dose, with the relative risk at 1 Sv being 1.00 (95% confidence interval 0.94, 1.07), which contrasts with that based on the atomic bomb survivors, 1.60 (1.27, 1.99). The difference in effect between the two studies almost certainly did not arise by chance (P = 0.0001). This study provides strong support from data for humans for a substantial fractionation/dose-rate effect for low-linear energy transfer radiation and lung cancer risk. This implies that lung cancer risk from exposures to such radiation at present-day dose rates is likely to be lower than would be predicted by current radiation risk models based on studies of high-dose-rate exposures. 25 refs., 8 tabs.

Howe, G.R. [Univ. of Toronto, Ontario (Canada)

1995-06-01T23:59:59.000Z

49

ORISE: DOE's Radiation Exposure Monitoring System (REMS)  

NLE Websites -- All DOE Office Websites (Extended Search)

Monitoring System (REMS) Monitoring System (REMS) ORISE maintains large database of radition exposure records for the U.S. Department of Energy ORISE staff monitoring radiation data for DOE Rule 10 CFR 835 establishes the U.S. Department of Energy's (DOE) occupational protection rule and requires assessment and recording of radiation doses to individuals who are exposed to sources of radiation or contamination. The Radiation Exposure Monitoring System (REMS) database is the radiation exposure data repository for all monitored DOE employees, contractors, subcontractors and members of the public. REMS maintains dose records for all monitored individuals dating back to 1969. Aggregated, site-specific data are available on the Radiation Exposure Monitoring System website for all years since 1986. Currently,

50

Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication  

SciTech Connect

The objective of the project was to elucidate the mechanisms underlying the biological effects of low dose/low dose rate ionizing radiation in organs/tissues of irradiated mice that differ in their susceptibility to ionizing radiation, and in human cells grown under conditions that mimic the natural in vivo environment. The focus was on the effects of sparsely ionizing cesium-137 gamma rays and the role of oxidative metabolism and intercellular communication in these effects. Four Specific Aims were proposed. The integrated outcome of the experiments performed to investigate these aims has been significant towards developing a scientific basis to more accurately estimate human health risks from exposures to low doses ionizing radiation. By understanding the biochemical and molecular changes induced by low dose radiation, several novel markers associated with mitochondrial functions were identified, which has opened new avenues to investigate metabolic processes that may be affected by such exposure. In particular, a sensitive biomarker that is differentially modulated by low and high dose gamma rays was discovered.

Azzam, Edouard I

2013-01-16T23:59:59.000Z

51

Composite scintillators for detection of ionizing radiation ...  

Building Energy Efficiency; Electricity Transmission; Energy Analysis; Energy ... Fluorescent Nanoparticles for Radiation DetectionFluorescent Nanoparticles for ...

52

NIST Ionizing Radiation Division 1999 - Current Directions  

Science Conference Proceedings (OSTI)

... effect relationships for radiation-induced stochastic ... validate the EPR dose assessment methods ... Calibration of Low-Energy Photon Brachytherapy ...

53

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMANEXPLOSIONS AND MEDICAL RADIATION . Jacob I. Fabrikant, MD,Low Levels of Ionizing Radiation, Yale University School of

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

54

Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation.  

NLE Websites -- All DOE Office Websites (Extended Search)

Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Krassimira Botcheva, John J. Dunn and Carl W. Anderson Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA The effects of exposure to low doses of ionizing radiation on humans results largely from changes in gene expression mediated by the activation of sequence-specific DNA binding proteins (transcription factors) as well as changes to other chromosomal proteins and perhaps to DNA. To develop a molecular understanding of the consequences of exposures to low doses of ionizing radiation, it will be necessary to understanding where radiation-activated transcription factors bind in whole genomes and how

55

NIST Ionizing Radiation Division 1999 - Future Directions  

Science Conference Proceedings (OSTI)

... to test the applicability of EPR tooth enamel retrospective dosimetry to dose assessment of background radiation. The low-dose threshold (dose ...

56

NIST Ionizing Radiation Division 2001 - Program Directions  

Science Conference Proceedings (OSTI)

... seen a tremendous increase in the use of low-energy photon ... for the high levels of absorbed dose used in the industrial radiation processing of ...

57

NIST Ionizing Radiation Division 1998 - Current Directions  

Science Conference Proceedings (OSTI)

... Cs gamma-ray ranges, and the low-energy photon ... beam, and a high-dose- rate Gammacell used in our radiation-processing dosimetry ...

58

Quantitative Phosphoproteomics Identifies Filaggrin and other Targets of Ionizing Radiation in a Human Skin Model  

Science Conference Proceedings (OSTI)

Our objective here was to perform a quantitative phosphoproteomic study on a reconstituted human skin tissue to identify low and high dose ionizing radiation dependent signaling in a complex 3-dimensional setting. Application of an isobaric labeling strategy using sham and 3 radiation doses (3, 10, 200 cGy) resulted in the identification of 1113 unique phosphopeptides. Statistical analyses identified 151 phosphopeptides showing significant changes in response to radiation and radiation dose. Proteins responsible for maintaining skin structural integrity including keratins and desmosomal proteins (desmoglein, desmoplakin, plakophilin 1 and 2,) had altered phosphorylation levels following exposure to both low and high doses of radiation. A phosphorylation site present in multiple copies in the linker regions of human profilaggrin underwent the largest fold change. Increased phosphorylation of these sites coincided with altered profilaggrin processing suggesting a role for linker phosphorylation in human profilaggrin regulation. These studies demonstrate that the reconstituted human skin system undergoes a coordinated response to ionizing radiation involving multiple layers of the stratified epithelium that serve to maintain skin barrier functions and minimize the damaging consequences of radiation exposure.

Yang, Feng; Waters, Katrina M.; Webb-Robertson, Bobbie-Jo M.; Sowa, Marianne B.; Freiin von Neubeck, Claere H.; Aldrich, Joshua T.; Markillie, Lye Meng; Wirgau, Rachel M.; Gristenko, Marina A.; Zhao, Rui; Camp, David G.; Smith, Richard D.; Stenoien, David L.

2012-04-17T23:59:59.000Z

59

Ionic Liquids and Ionizing Radiation: Reactivity of Highly Energetic  

NLE Websites -- All DOE Office Websites (Extended Search)

Ionizing Radiation: Reactivity of Highly Energetic Ionizing Radiation: Reactivity of Highly Energetic Species James F. Wishart J. Phys. Chem. Lett. 1, 3225-3231 (2010). [Find paper at ACS Publications] or use ACS Articles on Request View the video on this Perspective article at The Journal of Physical Chemistry Letters (5:03) Selected for the ACS Special Virtual Issue on Ionic Liquids (March 2011). Abstract: Due to their unique properties, ionic liquids present many opportunities for basic research on the interactions of radiation with materials under conditions not previously available. At the same time, there are practical applied reasons for characterizing, understanding, and being able to predict how ionic-liquid-based devices and industrial-scale systems will perform under conditions of extreme reactivity, including radiation. This

60

Sources Of Average Individual Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

Of Average Individual Radiation Exposure Of Average Individual Radiation Exposure Natural background Medical Consumer products Industrial, security, educational and research Occupational 0.311 rem 0.300 rem 0.013 rem 0.0003 rem 0.0005 rem Savannah River Nuclear Solutions, LLC, provides radiological protection services and oversight at the Savannah River Site (SRS). These services include radiation dose measurements for persons who enter areas where they may be exposed to radiation or radioactive material. The results are periodically reported to monitored individuals. The results listed are based on a radiation dose system developed by the International Commission on Radiation Protection. The system uses the terms "effective dose," "equivalent dose" and units of rem. You may be more familiar with the term "millirem" (mrem), which is 1/1000 of a rem.

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

10.2. Protection from ionizing radiation  

Science Conference Proceedings (OSTI)

exposure will be X-ray generators and radioisotopes used in the manufacture of specimens for ... (vi) during operation the dose equivalent at any accessible surface outside the ... source in the event of the loss of electrical power. 10.2.2.2.

62

Low Dose Radiation Research Program: Research Highlights - Ionizing  

NLE Websites -- All DOE Office Websites (Extended Search)

Affects Cancer Frequency and Characteristics by Acting Affects Cancer Frequency and Characteristics by Acting on the Microenvironment Background: For more than a quarter century the scientific rationale for extrapolating radiation health effects has been underpinned by biophysical target theory. Fundamental to target theory is that the effect (e.g., DNA damage, mutation, cancer) is proportional to dose based on interaction of energy with biological targets, specifically DNA. However, the biology following ionizing radiation is more than just DNA damage, repair, or misrepair. Cellular responses to ionizing radiation can affect phenotype, cell interactions, lineage commitment, differentiation and genomic stability, all of which have been widely documented in cultured cells and many observed in vivo. This class of non-targeted effects induced

63

Computational phenotype prediction of ionizing-radiation-resistant bacteria with a multiple-instance learning model  

Science Conference Proceedings (OSTI)

Ionizing-radiation-resistant bacteria (IRRB) are important in biotechnology. The use of these bacteria for the treatment of radioactive wastes is determined by their surprising capacity of adaptation to radionuclides and a variety of toxic molecules. ... Keywords: ionizing-radiation-resistant bacteria, ionizing-radiation-sensitive bacteria, multiple-instance learning, phenotypic prediction, protein sequences

Sabeur Aridhi; Mondher Maddouri; Haitham Sghaier; Engelbert Mephu Nguifo

2013-08-01T23:59:59.000Z

64

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary Genetic susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders Lawrence Berkeley National Laboratory Abstract Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer. Background and Significance: It is increasingly believed that individuals differ in their genetic susceptibilities to environmental insults for diseases such as cancer. This concern is especially important for the large numbers of individuals receiving low-dose exposures in the nuclear energy

65

DOE occupational radiation exposure 1996 report  

SciTech Connect

The goal of the US Department of Energy (DOE) is to conduct its radiological operations to ensure the health and safety of all DOE employees including contractors and subcontractors. The DOE strives to maintain radiation exposures to its workers below administrative control levels and DOE limits and to further reduce these exposures and releases to levels that are ``As Low As Reasonably Achievable`` (ALARA). The DOE Occupational Radiation Exposure Report, 1996 provides summary and analysis of the occupational radiation exposure received by individuals associated with DOE activities. The DOE mission includes stewardship of the nuclear weapons stockpile and the associated facilities, environmental restoration of DOE and precursor agency sites, and energy research. Collective exposure at DOE has declined by 80% over the past decade due to a cessation in opportunities for exposure during the transition in DOE mission from weapons production to cleanup, deactivation and decommissioning, and changes in reporting requirements and dose calculation methodology. In 1996, the collective dose decreased by 10% from the 1995 value due to decreased doses at five of the seven highest-dose DOE sites. For 1996, these sites attributed the reduction in collective dose to the completion of several decontamination and decommissioning projects, reduced spent fuel storage activities, and effective ALARA practices. This report is intended to be a valuable tool for managers in their management of radiological safety programs and commitment of resources.

NONE

1996-12-31T23:59:59.000Z

66

Low dose ionizing radiation induces tumor growth promoting factors in  

NLE Websites -- All DOE Office Websites (Extended Search)

ionizing radiation induces tumor growth promoting factors in ionizing radiation induces tumor growth promoting factors in stress-induced premature senescent fibroblasts David Boothman University of Texas Southwestern Medical Center at Dallas Abstract Recent evidence suggest that the causes of cancer development are not limited to mutations within cancer cells, but also involve in alterations of cancer microenvironment. Senescent cells are irreversibly growth arrested, but remain metabolically active. Senescent cells, especially senescent fibroblasts in the stroma may provide a beneficial environment for tumor growth through secretion of certain factors. Accumulation of senescent cells in the stroma of patients repeatedly exposed to low doses of IR or low dose rates of IR, could be an important factor, causing alteration of the microenvironment that ultimately benefits tumor

67

Low dose diagnostic radiation exposure and cancer risk in Trp53+/- mice  

NLE Websites -- All DOE Office Websites (Extended Search)

diagnostic radiation exposure and cancer risk in Trp53+/- mice diagnostic radiation exposure and cancer risk in Trp53+/- mice K Taylor, N Phan, ME Cybulski, L Laframboise, DR Boreham Department of Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main Street West, Hamilton ON L8S 4K1 The cancer risk associated with exposure to low doses of ionizing radiation has traditionally been extrapolated from effects observed at high doses and high dose rates using a linear no threshold model. Based on this approach, it has been postulated that human exposure to medical imaging involving low doses of x-rays and gamma rays increase an individual's risk of developing cancer throughout their lifetime. Conversely, there is evidence that low doses of gamma radiation increase the latency period of cancer depending upon genotype, cancer type, and the magnitude of

68

DOE 2012 Occupational Radiation Exposure October 2013  

SciTech Connect

The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. As an indicator of the overall amount of radiation dose received during the conduct of operations at DOE, the report includes information on collective total effective dose (TED). The TED is comprised of the effective dose (ED) from external sources, which includes neutron and photon radiation, and the internal committed effective dose (CED), which results from the intake of radioactive material into the body. The collective ED from photon exposure decreased by 23% between 2011 and 2012, while the neutron dose increased by 5%. The internal dose components of the collective TED decreased by 7%. Over the past 5-year period, 99.99% of the individuals receiving measurable TED have received doses below the 2 roentgen equivalent in man (rems) (20 millisievert [mSv]) TED administrative control level (ACL), which is well below the DOE regulatory limit of 5 rems (50 mSv) TED annually. The occupational radiation exposure records show that in 2012, DOE facilities continued to comply with DOE dose limits and ACLs and worked to minimize exposure to individuals. The DOE collective TED decreased 17.1% from 2011 to 2012. The collective TED decreased at three of the five sites with the largest collective TED. u Idaho Site – Collective dose reductions were achieved as a result of continuing improvements at the Advanced Mixed Waste Treatment Project (AMWTP) through the planning of drum movements that reduced the number of times a container is handled; placement of waste containers that created highradiation areas in a centralized location; and increased worker awareness of high-dose rate areas. In addition, Idaho had the largest decrease in the total number of workers with measurable TED (1,143 fewer workers). u Hanford Site (Hanford) – An overall reduction of decontamination and decommissioning (D&D) activities at the Plutonium Finishing Plant (PFP) and Transuranic (TRU) retrieval activities resulted in collective dose reductions. u Savannah River Site (SRS) – Reductions were achieved through ALARA initiatives employed site wide. The Solid Waste Management Facility used extended specialty tools, cameras and lead shield walls to facilitate removal of drums. These tools and techniques reduce exposure time through improved efficiency, increase distance from the source of radiation by remote monitoring, shield the workers to lower the dose rate, and reduce the potential for contamination and release of material through repacking of waste. Overall, from 2011 to 2012, there was a 19% decrease in the number of workers with measurable dose. Furthermore, due to a slight decrease in both the DOE workforce (7%) and monitored workers (10%), the ratio of workers with measurable doses to monitored workers decreased to 13%. Another primary indicator of the level of radiation exposure covered in this report is the average measurable dose, which normalizes the collective dose over the population of workers who actually received a measurable dose. The average measurable TED in

none,

2012-02-02T23:59:59.000Z

69

Induction of nuclear factor kB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway  

Science Conference Proceedings (OSTI)

Reactive oxygen intermediates (ROIs) have been found to be the messengers in the activation of the kB transcription regulator in mitogen- or cytokine-stimulated cells, operating in conjunction with or independently of various other mechanisms; these include Ca{sup ++}-dependent and PKC-dependent cytoplasmic signaling pathways. We have recently reported that low-dose ionizing radiation induces NF-kB in human lymphoblastoid 244B cells. Since ionizing radiation generates free radicals in cells, we have investigated whether the ROIs generated by ionizing radiation induce NF-kB activity, and also whether they do so by a similar mechanism as in cells treated with PMA or H{sub 2}O{sub 2}. The results not only confirm a previous observation from our laboratory that low-dose ionizing radiation (0.1-2.0 Gy) activates kB transcription factor transiently with a maximal induction at 0.5 Gy exposure, but also demonstrate mechanistically that the activation of NF-kB by low-dose ionizing radiation can be inhibited considerably by the antioxidant N-acetyl-L-cysteine, indicating that at least the major part of the activation process is mediated by ROIs. These findings support the idea that ROIs can regulate the kB elements which in turn can serve as response elements for oxidant stress. 37 refs., 4 figs., 1 tab.

Mohan, N.; Meltz, M.L. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-10-01T23:59:59.000Z

70

Review of exposure limits and experimental data for corneal and lenticular damage from short pulsed UV and IR laser radiation  

E-Print Network (OSTI)

for publication 30 October 2007; published 22 April 2008 Laser exposure limits as promulgated by the International at the international level by ICNIRP the International Commission on Non-Ionizing Radiation Protection.1,2 OtherReview of exposure limits and experimental data for corneal and lenticular damage from short pulsed

71

Low Dose Radiation Research Program: Low Dose Ionizing Radiation-Induced  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Ionizing Radiation-Induced Effects in Irradiated and Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Authors: B.E. Lehnert, R. Cary, D. Gadbois, and G. Gupta. Institutions: Bioscience Division, Los Alamos National Laboratory. The scientific literature presents a confusing picture concerning health risks due to low dose ionizing radiation (LDIR), e.g., <1-10 cGy. Some effects of LDIR such as enhanced rates of cell proliferation and the induction of radioadaptation may be benign under some circumstances. Other evidence suggests LDIR can be hazardous and that a threshold for potentially detrimental responses, e.g., increases in intracellular reactive oxygen species (ROS), increases in sister chromatid exchanges (SCE), alterations in gene or protein expression profiles, and increased

72

Development of Pattern Recognition Software for Tracks of Ionizing Radiation In Medipix2-Based  

E-Print Network (OSTI)

, and area monitors to characterize the general background radiation environment harmful to humansDevelopment of Pattern Recognition Software for Tracks of Ionizing Radiation In Medipix2-Based tool for the automated identification and classification of tracks of ionizing radiation as measured

Vilalta, Ricardo

73

Investigation of non-targeted effects of low dose ionizing radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains...

74

Role of ATM kinase in ionizing radiation induced DNA damage response...  

NLE Websites -- All DOE Office Websites (Extended Search)

ATM kinase in ionizing radiation induced DNA damage response in human neural stemprogenitor cells and differentiated cell types Adayabalam Balajee Columbia University Medical...

75

Using Co-Regulation to Understand Low-Dose Ionizing Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

with low and high doses of ionizing radiation (IR). Pathway analysis suggested that chromatin structure, as well as transcription control, plays a large role in linking gene...

76

DOE 2008 Occupational Radiation Exposure October 2009  

Science Conference Proceedings (OSTI)

A major priority of the U.S. Department of Energy (DOE) is to ensure the health, safety, and security of DOE employees, contractors, and subcontractors. The Office of Health, Safety and Security (HSS) provides the corporate-level leadership and strategic vision necessary to better coordinate and integrate health, safety, environment, security, enforcement, and independent oversight programs. One function that supports this mission is the DOE Corporate Operating Experience Program that provides collection, analysis, and dissemination of performance indicators, such as occupational radiation exposure information. This analysis supports corporate decision-making and synthesizes operational information to support continuous environment, safety, and health improvement across the DOE complex.

U.S. Department of Energy, Office of Health, Safety and Security

2009-10-01T23:59:59.000Z

77

Irradiators for measuring the biological effects of low dose-rate ionizing radiation fields  

E-Print Network (OSTI)

Biological response to ionizing radiation differs with radiation field. Particle type, energy spectrum, and dose-rate all affect biological response per unit dose. This thesis describes methods of spectral analysis, ...

Davidson, Matthew Allen

2011-01-01T23:59:59.000Z

78

CORROSION PRODUCT TRANSPORT AND DEPOSITION UNDER IONIZING RADIATION  

DOE Green Energy (OSTI)

A study was made of corrosion product transport and deposition on Zircaloy-2 and AISI 304 stainless steel in the presence and absence of ionizing radiation. Three 100-hour irradiation tests, using 2-Mev electrons from a Van de Graaff accelerator, and four 100-hour nonradiation tests were performed in 6O0 deg F pressurized water. Data from the seven runs and an additional exploratory run are presented. In addition, complete experimental procedures and descriptions of the apparatus are included. Control of pH was obtained by using H and OH form ion exchange resias for pH 7 and Li and OH form ion exchange resins for pH 10. The major conclusion to be drawn from the present work is that the deposition on Zircaloy-2 at pH 10 and 600 deg F is higher than on AISI 304 stainless steel at the same conditions. (auth)

Thomas, C.C. Jr.; Lacock, H.W.; Cadoff, H.Y. ed.

1958-12-01T23:59:59.000Z

79

Recombining WMAP: constraints on ionizing and resonance radiation at recombination  

E-Print Network (OSTI)

We place new constraints on sources of ionizing and resonance radiation at the epoch of the recombination process using the recent CMB temperature and polarization spectra coming from WMAP. We find that non-standard recombination scenarios are still consistent with the current data. In light of this we study the impact that such models can have on the determination of several cosmological parameters. In particular, the constraints on curvature and baryon density appear to be weakly affected by a modified recombination scheme. However, it may affect the current WMAP constraints on inflationary parameters like the spectral index and its running. Physically motivated models, like those based on primordial black hole or super heavy dark matter decay, are able to provide a good fit to the current data. Future observations in both temperature and polarization will be needed to more stringently test these models.

Rachel Bean; Alessandro Melchiorri; Joe Silk

2003-06-18T23:59:59.000Z

80

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Understanding how human organs respond to ionizing radiation (IR) at a systems biology level and identifying biomarkers for IR exposure at low doses can help provide a scientific basis for establishing radiation protection standards. Little is known regarding the physiological responses to low dose IR at the metabolite level, which represents the end-point of biochemical processes inside cells. Using a full thickness human skin tissue model and GC-MS-based metabolomics analysis, we examined the metabolic perturbations at three time points (3, 24 and 48 hr) after exposure to 3, 10 and 200 cGy of X-rays. PLS-DA score plots revealed dose- and time-dependent clustering between sham and irradiated groups. Importantly, a comparable number of metabolites were detected to have significant change 48 hr after exposure to 3 and 10 cGy of irradiation, when compared with the high dose of 200 cGy. Biochemical pathway analysis showed perturbations to DNA/RNA damage and repair, lipid and energy metabolisms, even at low doses of IR.

Hu, Zeping; Kim, Young-Mo; Sowa, Marianne B.; Robinson, Robert J.; Gao, Xiaoli; Metz, Thomas O.; Morgan, William F.; Zhang, Qibin

2012-05-18T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

A Basic Overview of the Occupational Radiation Exposure Monitoring...  

NLE Websites -- All DOE Office Websites (Extended Search)

and dissemination of occupational radiation exposure information. The annual REMS report is a valuable tool for managing radiological safety programs and for developing...

82

ORISE: Worker Health Studies - Radiation Exposure Data Collection  

NLE Websites -- All DOE Office Websites (Extended Search)

Overview Argonne Electronic Medical Records System Beryllium Testing and Surveillance Radiation Exposure Information and Reporting System (REIRS) U.S. Department of Energy...

83

Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation  

SciTech Connect

Nuclear factor kB (NF-kB) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kB in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kB in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to {sup 137}Cs {gamma} rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kB was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kB was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kB subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy. 32 refs., 3 figs.

Prasad, A.V.; Mohan, N.; Meltz, M.L.; Chandrasekar, B. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-06-01T23:59:59.000Z

84

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation  

SciTech Connect

Exposure to ionizing radiation results in the immediate formation of free radicals and other reactive oxygen species (ROS). It has been assumed that the subsequent injury processes leading to genomic instability and carcinogenesis following radiation, derive from the initial oxidative damage caused by these free radicals and ROS. It is now becoming increasingly obvious that metabolic oxidation/reduction (redox) reactions can be altered by irradiation leading to persistent increases in steady-state levels of intracellular free radicals and ROS that contribute to the long term biological effects of radiation exposure by causing chronic oxidative stress. The objective during the last period of support (DE-FG02-05ER64050; 5/15/05-12/31/09) was to determine the involvement of mitochondrial genetic defects in metabolic oxidative stress and the biological effects of low dose/low LET radiation. Aim 1 was to determine if cells with mutations in succinate dehydrogenase (SDH) subunits C and D (SDHC and SDHD in mitochondrial complex II) demonstrated increases in steady-state levels of reactive oxygen species (ROS; O2•- and H2O2) as well as demonstrating increased sensitivity to low dose/low LET radiation (10 cGy) in cultured mammalian cells. Aim #2 was to determine if mitochondrially-derived ROS contributed to increased sensitivity to low dose/low LET radiation in mammalian cells containing mutations in SDH subunits. Aim #3 was to determine if a causal relationship existed between increases in mitochondrial ROS production, alterations in electron transport chain proteins, and genomic instability in the progeny of irradiated cells. Evidence gathered in the 2005-2009 period of support demonstrated that mutations in genes coding for mitochondrial electron transport chain proteins (ETC); either Succinate Dehydrogenase (SDH) subunit C (SDHC) or subunit D (SDHD); caused increased ROS production, increased genomic instability, and increased sensitivity to low dose/low LET radiation that could be mitigated by over expression of the H2O2 metabolizing enzyme, catalase, and/or the mitochondrial form of superoxide dismutase (MnSOD). Furthermore, using radiation-induced genomically unstable cells, it was shown that steady-state levels of H2O2 were significantly elevated for many cell generations following exposure, catalase suppressed the radiation-induced mutator phenotype when added long after radiation exposure, unstable clones showed evidence of mitochondrial dysfunction some of which was characterized by improper assembly of SDH subunits (particularly subunit B), and chemical inhibitors of SDH activity could decrease steady-state levels of H2O2 as well as mutation frequency. These results support the hypotheses that 1) SDH mutations could contribute to transformation by inducing genomic instability and a mutator phenotype via increasing steady-state levels of ROS; 2) metabolic sources of O2•- and H2O2 play a significant role in low dose radiation induced injury and genomic instability; and 3) increased mutation rates in irradiated mammal cells can be suppressed by scavengers of H2O2 (particularly catalase) long after radiation exposure. Overall the results obtained during this period of support provide clear evidence in support of the hypothesis that abnormal oxidative metabolism in mitochondria that result in increases in steady-sate levels of H2O2 and other ROS are capable of significantly contributing to radiation-induced mutator phenotypes in mammalian cells.

Spitz, Douglas R.

2009-11-09T23:59:59.000Z

85

Introduction and Fundamentals: Course on Advances in Radiation  

E-Print Network (OSTI)

exposure to Ionizing Radiation - is it really necessary?"Sternglass, "Environmental Radiation and Human Health," op.on the Effects of Atomic Radiation Sources and Effects of

Thomas, Ralph H.

2010-01-01T23:59:59.000Z

86

ealth physics is concerned with protecting people from the harmful effects of ionizing radiation while allowing its beneficial use in medicine, science,  

E-Print Network (OSTI)

, particularly from medical exposures and from the atomic-bomb ex- posures in Hiroshima and Nagasaki. DuringH ealth physics is concerned with protecting people from the harmful effects of ionizing radiation effects such as cancer that had been observed in populations of people receiv- ing high doses

Massey, Thomas N.

87

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans  

SciTech Connect

Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated in irradiated human diploid fibroblasts. ASPM was recently reported as the causative gene for MCPH-5, the most common type of congenital microcephaly in humans. Here, we show that the expression of the Aspm gene was significantly reduced by IR in various human and murine cells. Additionally, Aspm was found downregulated in the irradiated fetal mouse brain, particularly in the ventricular zones. A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation.

Fujimori, Akira [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)], E-mail: fujimora@nirs.go.jp; Yaoi, Takeshi; Ogi, Hiroshi [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan); Wang Bing [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Suetomi, Katsutoshi; Sekine, Emiko; Yu Dong; Kato, Takamitsu [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Takahashi, Sentaro [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Okayasu, Ryuichi [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Itoh, Kyoko; Fushiki, Shinji [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan)

2008-05-09T23:59:59.000Z

88

DOE occupational radiation exposure. Report 1992--1994  

Science Conference Proceedings (OSTI)

The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE`s performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace.

NONE

1997-05-01T23:59:59.000Z

89

DOE Basic Overview of Occupational Radiation Exposure_2011 pamphlet  

SciTech Connect

This pamphlet focusses on two HSS activities that help ensure radiation exposures are accurately assessed and recorded, namely: 1) the quality and accuracy of occupational radiation exposure monitoring, and 2) the recording, reporting, analysis, and dissemination of the monitoring results. It is intended to provide a short summary of two specific HSS programs that aid in the oversight of radiation protection activities at DOE. The Department of Energy Laboratory Accreditation Program (DOELAP) is in place to ensure that radiation exposure monitoring at all DOE sites is precise and accurate, and conforms to national and international performance and quality assurance standards. The DOE Radiation Exposure Monitoring Systems (REMS) program provides for the collection, analysis, and dissemination of occupational radiation exposure information. The annual REMS report is a valuable tool for managing radiological safety programs and for developing policies to protect individuals from occupational exposure to radiation. In tandem, these programs provide DOE management and workers an assurance that occupational radiation exposures are accurately measured, analyzed, and reported.

ORAU

2012-08-08T23:59:59.000Z

90

IONIZING RADIATION RISKS TO SATELLITE POWER SYSTEMS (SPS) WORKERS  

E-Print Network (OSTI)

and A. I. Sladkova, "Radiation Levels in InterplanetaryPrognoz Satellites," Cosmic Radiation, 12_, No. 5, 716-718 (0. ArchamDeau, Mammalian Radiation Lethargy, A Disturbance

Lyman, J.T.

2010-01-01T23:59:59.000Z

91

Regulation of Annexin A2 by Ionizing Radiation in Human Skin...  

NLE Websites -- All DOE Office Websites (Extended Search)

Annexin A2 by Ionizing Radiation in Human Skin Equivalent Culture: Does A Nuclear Annexin A2-Protein Kinase C Epsilon Complex Contribute To Reduced Cancer Risks At Low Dose...

92

Regulation of Annexin A2 by Ionizing Radiation in Human Skin...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Annexin A2 by Ionizing Radiation in Human Skin Equivalent Culture: Does A Nuclear Annexin A2-Protein Kinase C Epsilon Complex Contribute To Reduced Cancer Risks At Low...

93

ORISE: U.S. Nuclear Regulatory Commission Radiation Exposure Information  

NLE Websites -- All DOE Office Websites (Extended Search)

Information and Reporting System (REIRS) Information and Reporting System (REIRS) ORISE maintains large database of radiation exposure records for the U.S. Nuclear Regulatory Commission U.S. Nuclear Regulatory Commission Radiation Exposure Information and Reporting System (REIRS) The U.S. Nuclear Regulatory Commission (NRC) is required by federal mandate to maintain and evaluate radiation protection data for workers at facilities that it licenses. As part of its mission of safety, the NRC operates the Radiation Exposure Information and Reporting System (REIRS), a database system containing all occupational radiation exposure records that have been submitted to the NRC under 10 CFR Part 20. REIRS encompasses 1,800-plus NRC licensees and contains more than five million records for more than one million monitored individuals.

94

Global methylation responses to low dose radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

methylation responses to low dose radiation exposure methylation responses to low dose radiation exposure Pamela J Sykes, Michelle R Newman, Benjamin J Blyth and Rebecca J Ormsby Haematology and Genetic Pathology, Flinders University and Medical Centre, Flinders Centre for Cancer Prevention and Control, Bedford Park, Adelaide, South Australia 5042 Australia. (pam.sykes@flinders.edu.au). Our goal is to study the mechanisms involved in biological responses to low doses of radiation in vivo in the dose range that is relevant to population and occupational exposures. At high radiation doses, DNA double-strand breaks are considered the critical lesion underlying the initiation of radiation-induced carcinogenesis. However, at the very low radiation doses relevant for the general public, the induction of DNA double-strand breaks

95

DOE 2010 Occupational Radiation Exposure November 2011  

Science Conference Proceedings (OSTI)

This report discusses radiation protection and dose reporting requirements, presents the 2010 occupational radiation dose data trended over the past 5 years, and includes instructions to submit successful ALARA projects.

U.S. Department of Energy, Office of Health, Safety and Security, Office of Analysis

2011-11-11T23:59:59.000Z

96

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

exposure to radioactive fallout in Radiation-Associated inIslanders, who were exposed to fallout H-bomb test explosion

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

97

Radiation-induced attenuation of high-OH optical fibers after hydrogen treatment in the presence of ionizing radiation  

DOE Green Energy (OSTI)

High purity, high-OH, optical fibers were irradiated in a hydrogen atmosphere to explore hydrogen binding into defects created by the ionizing radiation. Significant improvements in subsequent measurements of radiation-induced attenuation were observed. 18 refs., 4 figs., 2 tabs.

Lyons, P.B; Looney, L.D.

1991-01-01T23:59:59.000Z

98

Perspectives of Decision-Making and Estimation of Risk in Populations Exposed to Low Levels of Ionizing Radiations  

E-Print Network (OSTI)

exposure to radioactive fallout in radiation-associatedheight of the radioactive fallout deliberations in the early

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

99

Use of ionizing radiation for fixing textile resins on wool. [Gamma rays  

SciTech Connect

Ambient-temperature treatments with ionizing radiation can be used as an alternative to conventional thermal/catalytic cure methods of fixing textile resins on wool materials. The effectiveness of the radiation-induced fixation of resins on wool has been demonstrated by machine-wash shrinkage tests on fabrics treated with a variety of commercial polymer resins.

McLaren, K.G.

1980-04-01T23:59:59.000Z

100

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland  

NLE Websites -- All DOE Office Websites (Extended Search)

non-targeted effects of low dose ionizing radiation on the mammary gland non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains that differ in susceptibility to tumorigenesis Joni D. Mott, Antoine M. Snijders, Alvin Lo, Dinah Levy-Groesser, Bahram Parvin, Andrew J. Wyrobek, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's SFA, Project 2, our studies focus on utilizing three dimensional (3D) cell culture models as surrogates for in vivo studies to determine how low doses of ionizing radiation influence mammary gland tissue architecture and how this may relate both to tumor progression and/or adaptive response.

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivi...  

NLE Websites -- All DOE Office Websites (Extended Search)

Our research utilizes radiation cataract as a model system to study the effects of low-dose ionizing radiation exposure in a complex, highly differentiated tissue. We believe...

102

Low Dose Radiation Research Program: Research Highlights - Ionizing...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy Low Dose Radiation Research Program, and the Department of Defense Breast Cancer Research program and Prostate Cancer Research program. Researchers include Eva...

103

NIST Ionizing Radiat. Div. - 2004: Strategic Focus 3  

Science Conference Proceedings (OSTI)

... of high levels of absorbed dose, as required in the industrial radiation processing of ... tremendous increase in the use of low-energy, photon ...

104

NIST Ionizing Radiat. Div. - 2002: Strategic Focus 3  

Science Conference Proceedings (OSTI)

... of high levels of absorbed dose, as required in the industrial radiation processing of ... tremendous increase in the use of low-energy, photon ...

105

NIST Ionizing Radiat. Div. - 2004: Strategic Focus 2  

Science Conference Proceedings (OSTI)

... electronic radiation monitors ("pagers"), isotope identifier instruments ... 2003, DOE recognized this program as one of the top-ten programs relevant to ...

106

Program on Technology Innovation: Evaluation of Updated Research on the Health Effects and Risks Associated with Low-Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

The Electric Power Research Institute (EPRI) has performed a systematic review of recently published, peer-reviewed scientific studies in the fields of epidemiology and radiobiology that discuss health risks associated with exposure to low levels of ionizing radiation. As a result of this study, the EPRI team concludes that there is a need to re-evaluate the magnitude of dose and dose-rate effectiveness factors (DDREF), including the significant body of radiobiology data that suggests non-linear risks at...

2009-11-18T23:59:59.000Z

107

Health Impacts from Acute Radiation Exposure  

SciTech Connect

Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

Strom, Daniel J.

2003-09-30T23:59:59.000Z

108

Environmental radiation exposure: Regulation, monitoring, and assessment  

Science Conference Proceedings (OSTI)

Radioactive releases to the environment from nuclear facilities constitute a public health concern. Protecting the public from such releases can be achieved through the establishment and enforcement of regulatory standards. In the United States, numerous standards have been promulgated to regulate release control at nuclear facilities. Most recent standards are more restrictive than those in the past and require that radioactivity levels be as low as reasonably achievable (ALARA). Environmental monitoring programs and radiological dose assessment are means of ensuring compliance with regulations. Environmental monitoring programs provide empirical information on releases, such as the concentrations of released radioactivity in environmental media, while radiological dose assessment provides the analytical means of quantifying dose exposures for demonstrating compliance.

Chen, S.Y.; Yu, C.; Hong, K.J.

1991-01-01T23:59:59.000Z

109

Does nitrate deposition following astrophysical ionizing radiation events pose an additional threat to amphibians?  

E-Print Network (OSTI)

It is known that amphibians are especially susceptible to the combination of heightened UVB radiation and increased nitrate concentrations. Various astrophysical events have been suggested as sources of ionizing radiation that could pose a threat to life on Earth, through destruction of the ozone layer and subsequent increase in UVB, followed by deposition of nitrate. In this study, we investigate whether the nitrate deposition following an ionizing event is sufficiently large to cause an additional stress beyond that of the heightened UVB previously considered. We have converted predicted nitrate depositions to concentration values, utilizing data from the New York State Department of Environmental Conservation Acid Rain Monitoring Network web site. Our results show that the increase in nitrate concentration in bodies of water following the most intense ionization event likely in the last billion years would not be sufficient to cause a serious additional stress on amphibian populations and may actually provide some benefit by acting as fertilizer.

Brian C. Thomas; Michelle D. Honeyman

2008-04-22T23:59:59.000Z

110

Amphibian nitrate stress as an additional terrestrial threat from astrophysical ionizing radiation events?  

E-Print Network (OSTI)

As diversity in amphibian species declines, the search for causes has intensified. Work in this area has shown that amphibians are especially susceptible to the combination of heightened UVB radiation and increased nitrate concentrations. Various astrophysical events have been suggested as sources of ionizing radiation that could pose a threat to life on Earth, through destruction of the ozone layer and subsequent increase in UVB, followed by deposition of nitrate. In this study, we investigate whether the nitrate deposition following an ionizing event is sufficiently large to cause an additional stress beyond that of the heightened UVB previously considered. We have converted predicted nitrate depositions to concentration values, utilizing data from the New York State Department of Environmental Conservation Acid Rain Monitoring Network web site. Our results show that the increase in nitrate concentration in bodies of water following the most intense ionization event likely in the last billion years would no...

Thomas, Brian C

2008-01-01T23:59:59.000Z

111

Detection of Ionizing Radiation by Plasma-Panel Sensors: Cosmic Muons, Ion Beams, and Cancer Therapy  

Science Conference Proceedings (OSTI)

The plasma panel sensor is an ionizing photon and particle radiation detector derived from PDP technology with high gain and nanosecond response. Experimental results in detecting cosmic ray muons and beta particles from radioactive sources are described along with applications including high energy and nuclear physics, homeland security and cancer therapeutics.

Friedman, Dr. Peter S. [Integrated Sensors, LLC; Ferretti, Claudio [University of Michigan; Ball, Robert [University of Michigan; Beene, James R [ORNL; Ben Moshe, M. [Tel Aviv University; Benhammou, Yan [Tel Aviv University; Chapman, J. Wehrley [University of Michigan; Levin, Daniel S. [University of Michigan; Silver, Yiftah [Tel Aviv University; Weaverdyck, Curtis [University of Michigan; Zhou, Bing [University of Michigan; Etzion, E [Tel Aviv University; Moshe, M. [Tel Aviv University; Bentefour, E [Ion Beam Applications

2012-01-01T23:59:59.000Z

112

The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis  

E-Print Network (OSTI)

The ability of ionizing radiation to enhance colon carcinogenesis and the role of diet in this process has not been documented. We hypothesized that radiation would enhance the formation of aberrant crypt foci, ACF, known precursor lesions to colon cancer, by suppressing apoptosis and upregulating proliferation in colonocytes. Diets contained a combination of fish oil or corn oil and either pectin or cellulose. We exposed 40 male Sprague-Dawley rats to 1 Gy ionizing radiation (1 GeV Fe) 10 d prior to injection with AOM. Colons were resected at the promotion stage of carcinogenesis (7 wk post initial injection) and assayed for ACF and apoptosis. Radiation treatment increased (P=0.0327) the incidence of high multiplicity ACF (foci with four or more aberrant crypts) and decreased (P=0.0340) the apoptotic index compared to non-irradiated rats. Radiation also resulted in an increase (PACF compared to the corn oil treatment. Dietary pectin significantly increased (P=0.0204) the apoptotic index compared to cellulose treatment. These data suggest that ionizing radiation can work synergistically with AOM and increase the formation of high-multiplicity ACF, upregulate cellular proliferation and decrease apoptosis in colonocytes. The data also suggest that diets containing fish oil and pectin may protect against colon cancer by increasing apoptosis and reducing the formation of high multiplicity ACF.

Mann, John Clifford

2005-08-01T23:59:59.000Z

113

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

Atomic Bomb by Radiation Dose, Years Research Research after Survivors, Hiroshima and Nagasaki, 1950-71 Exposure, Age,atomic bomb survivors in Hiroshima and Nagasaki (36), and the Japanese Here, 'here is an The latent age-

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

114

DOE Radiation Exposure Monitoring System (REMS) Data Update  

SciTech Connect

This slide show presents the 2011 draft data for DOE occupational radiation exposure.Clarification is given on Reporting Data regarding: reporting Total Organ Dose (TOD); reporting Total Skin Dose (TSD), and Total Extremity Dose (TExD) ; and Special individuals reporting.

Rao, Nimi; Hagemeyer, Derek

2012-05-05T23:59:59.000Z

115

Reducing waste generation and radiation exposure by analytical method modification  

SciTech Connect

The primary goal of an analytical support laboratory has traditionally been to provide accurate data in a timely and cost effective fashion. Added to this goal is now the need to provide the same high quality data while generating as little waste as possible. At the Savannah River Technology Center (SRTC), we have modified and reengineered several methods to decrease generated waste and hence reduce radiation exposure. These method changes involved improving detection limits (which decreased the amount of sample required for analysis), decreasing reaction and analysis time, decreasing the size of experimental set-ups, recycling spent solvent and reagents, and replacing some methods. These changes had the additional benefits of reducing employee radiation exposure and exposure to hazardous chemicals. In all cases, the precision, accuracy, and detection limits were equal to or better than the replaced method. Most of the changes required little or no expenditure of funds. This paper describes these changes and discusses some of their applications.

Ekechukwu, A.A.

1996-10-01T23:59:59.000Z

116

Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse  

NLE Websites -- All DOE Office Websites (Extended Search)

Medical Center Abstract Background: Humans have evolved and thrived amidst constant low-dose (0-10 cGy) background radiation exposure from natural sources. Currently, however, the...

117

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation Deok-Jin Jang 1 , Mingquan Guo 1 , Julia S.F.Chu 2 , Kyle T. Kurpinski 2 , Bjorn Rydberg 1 , Song Li 2 , and Daojing Wang 1 1. Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720 2. Department of Bioengineering, University of California, Berkeley, CA 94720 We will present data obtained during the first year of our DOE/NASA Low Dose Radiation Research program. We utilized a comprehensive approach including transcriptomics, proteomics, phosphoproteomics, and biochemistry to characterize human mesenchymal stem cells (MSCs) in response to low dose ionizing radiation. We first determined the cell survival, proliferation, and osteogenic differentiation of

118

Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity  

SciTech Connect

Glioblastomas are among the malignancies most resistant to radiation therapy. In contrast, cells lacking the ATM protein are highly sensitive to ionizing radiation. The relationship between ATM protein expression and radiosensitivity in 3 glioma cell lines was examined. T98G cells exhibited normal levels of ATM protein, whereas U118 and U87 cells had significantly lower levels of ATM and increased (>2-fold) sensitivity to ionizing radiation compared to T98G cells. The ATM promoter was methylated in U87 cells. Demethylation by azacytidine treatment increased ATM protein levels in the U87 cells and decreased their radiosensitivity. In contrast, the ATM promoter in U118 cells was not methylated. Further, expression of exogenous ATM did not significantly alter the radiosensitivity of U118 cells. ATM expression is therefore heterogeneous in the glioma cells examined. In conclusion, methylation of the ATM promoter may account for the variable radiosensitivity and heterogeneous ATM expression in a fraction of glioma cells.

Roy, Kanaklata [Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115 (United States); Wang, Lilin [Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115 (United States); Makrigiorgos, G. Mike [Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115 (United States); Price, Brendan D. [Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115 (United States)]. E-mail: brendan_price@dfci.harvard.edu

2006-06-09T23:59:59.000Z

119

Limitations and Problems in Deriving Risk Estimates for Low-level Radiation Exposure  

E-Print Network (OSTI)

Some of the problems in determining the cancer risk of low-level radiation from studies of exposed groups are reviewed and applied to the study of Hanford workers by Mancuso, Stewart, and Kneale. Problems considered are statistical limitations, variation of cancer rates with geography and race, the "healthy worker effect, " calendar year and age variation of cancer mortality, choosing from long lists, use of proportional mortality rates, cigarette smoking-cancer correlations, use of averages to represent data distributions, ignoring other data, and correlations between radiation exposure and other factors that may cause cancer. The current status of studies of the Hanford workers is reviewed. There have been several papers in recent years purporting to give evidence that low level radiation (- 10 rad) is more dangerous than indicated by conventional estimates like those of the National Academy of Sciences Committee on Biological Effects of Ionizing Radiation (BEIR) [1], the United Nations Scientific Committee on Effects of Atomic Radiation (UNSCEAR) [21, and the International Commission on Radiological Protection (ICRP) [3]. The best known of these is the study by Mancuso, Stewart, and Kneale [4] (hereafter referred to as MSK) on workers at the

Bernard L. Cohen; D. Sc

1981-01-01T23:59:59.000Z

120

Effects of radiation exposure on SRL 131 composition glass in a steam environment  

Science Conference Proceedings (OSTI)

Monoliths of SRL 131 borosilicate glass were irradiated in a saturated air-steam environment, at temperatures of 150{degree}C, to examine the effects of radiation on nuclear waste glass behavior. Half of the tests used actinide and Tc-99 doped glass and were exposed to an external ionizing gamma source, while the remaining glass samples were doped only with uranium and were reacted without any external radiation exposure. The effects of radiation exposure on glass alteration and secondary phase formation were determined by comparing the reaction rates and mineral paragenesis of the two sets of samples. All glass samples readily reacted with the water that condensed on their surfaces, producing a smectite clay layer within the first three days of testing. Additional crystalline phases precipitated on the altered glass surface with increasing reaction times, including zeolites, smectite, calcium and sodium silicates, phosphates, evaporitic salts, and uranyl silicates. Similar phases were produced on both the nonirradiated and irradiated samples; however, the quantity of precipitates was increased and the rate of paragenetic sequence development was accelerated in the latter. After 56 days of testing, the smectite layer developed at an average rate of {approximately}0.16 and 0.63 {mu}m/day for the nonirradiated and irradiated samples, respectively. These comparisons indicate that layer development is accelerated approximately four-fold due to the radiation exposure at high glass surface area/liquid volume (SA/V) conditions. This increase apparently occurs in response to the rapid concentration of radiolytic products, including nitric acid, in the thin films of water contacting the sample monoliths.

Wronkiewicz, D.J.; Bradley, C.R.; Bates, J.K. [Argonne National Lab., IL (United States); Wang, L.M. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Geology

1993-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Occupational radiation Exposure at Agreement State-Licensed Materials Facilities, 1997-2010  

SciTech Connect

The purpose of this report is to examine occupational radiation exposures received under Agreement State licensees. As such, this report reflects the occupational radiation exposure data contained in the Radiation Exposure Information and Reporting System (REIRS) database, for 1997 through 2010, from Agreement State-licensed materials facilities.

U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research

2012-07-07T23:59:59.000Z

122

Technical specifications manual for the MARK-1 pulsed ionizing radiation detection system. Volume 1  

Science Conference Proceedings (OSTI)

The MARK-1 detection system was developed by the Idaho National Engineering Laboratory for the US Department of Energy Office of Arms Control and Nonproliferation. The completely portable system was designed for the detection and analysis of intense photon emissions from pulsed ionizing radiation sources. This manual presents the technical design specifications for the MARK-1 detection system and was written primarily to assist the support or service technician in the service, calibration, and repair of the system. The manual presents the general detection system theory, the MARK-1 component design specifications, the acquisition and control software, the data processing sequence, and the system calibration procedure. A second manual entitled: Volume 2: Operations Manual for the MARK-1 Pulsed Ionizing Radiation Detection System (USDOE Report WINCO-1108, September 1992) provides a general operational description of the MARK-1 detection system. The Operations Manual was written primarily to assist the field operator in system operations and analysis of the data.

Lawrence, R.S.; Harker, Y.D.; Jones, J.L.; Hoggan, J.M.

1993-03-01T23:59:59.000Z

123

Cosmological constraints in the presence of ionizing and resonance radiation at recombination  

E-Print Network (OSTI)

With the recent measurement of full sky cosmic microwave background polarization from WMAP, key cosmological degeneracies have been broken, allowing tighter constraints to be placed on cosmological parameters inferred assuming a standard recombination scenario. Here we consider the effect on cosmological constraints if additional ionizing and resonance radiation sources are present at recombination. We find that the new CMB data significantly improve the constraints on the additional radiation sources, with $\\log_{10}[\\epsilon_{\\alpha}] < -0.5$ and $\\log_{10}[\\epsilon_{i}] <-2.4$ at 95% c.l. for resonance and ionizing sources respectively. Including the generalized recombination scenario, however, we find that the constraints on the scalar spectral index $n_s$ are weakened to $n_s=0.98\\pm0.03$, with the $n_s=1$ case now well inside the 95% c.l.. The relaxation of constraints on tensor modes, scale invariance, dark energy and neutrino masses are also discussed.

Rachel Bean; Alessandro Melchiorri; Joe Silk

2007-01-09T23:59:59.000Z

124

Effects of Ionizing Radiation on Digital Single Event Transients in a 180-nm Fully Depleted SOI Process  

E-Print Network (OSTI)

Effects of ionizing radiation on single event transients are reported for Fully Depleted SOI (FDSOI) technology using experiments and simulations. Logic circuits, i.e. CMOS inverter chains, were irradiated with cobalt-60 ...

Keast, Craig L.

125

RADIATION MONITOR CONTAINING TWO CONCENTRIC IONIZATION CHAMBERS AND MEANS FOR INSULATING THE SEPARATE CHAMBERS  

DOE Patents (OSTI)

This invention relates to a portable radiation monitor containing two concentric ionization chambers which permit the use of standard charging and reading devices. It is particularly adapted as a personnel x-ray dosimeter and to this end comprises a small thin walled, cylindrical conductor forming an inner energy dependent chamber, a small thin walled, cylindrical conductor forming an outer energy independent chamber, and polymeric insulation means which insulates said chambers from each other and holds the chambers together with exposed connections in a simple, trouble-free, and compact assembly substantially without variation in directional response. (AEC)

Braestrup, C.B.; Mooney, R.T.

1964-01-21T23:59:59.000Z

126

Health Physics Society Specialists in Radiation Safety Radiation Exposure and Pregnancy  

E-Print Network (OSTI)

Everyone is exposed to radiation every day. People are continuously exposed to low-level radiation found in food, soils, building materials, and the air and from outer space. All of this radiation originates from naturally occurring sources. For example, bananas contain naturally occurring radioactive potassium-40 and air contains radon, a radioactive gas. Your average natural background radiation dose * is about 3.0 mSv (300 mrem) each year (millisieverts and millirem are units of radiation dose, much like a gram or an ounce is a unit of weight). In addition to natural background radiation, you may be exposed to radiation from medical x rays and medical radiation tests or treatments. If you think, or there is a possibility, that you may be pregnant and need a medical x-ray or radiation procedure, the information below will help answer your question “Does a medical procedure involving radiation increase my baby’s health risks?” What are the health risks from medical x rays or radionuclide medical tests performed during pregnancy? There is a lot of reliable information about the effects of radiation exposure during pregnancy. Potential radiation effects vary depending on the fetal stage of development and the magnitude of the doses. Our best knowledge indicates that there is a threshold below which negative effects are not observed. According to the American College of Radiology, routine x rays of a mother’s abdomen, back, hips, and pelvis are not likely to pose a serious risk to the child (ACR/RSNA 2010). However, certain procedures (such as a computerized tomography [CT scan] or a lower GI fluoroscope exam) to the mother’s stomach or hips may give higher doses. If you are administered a radioactive drug (nuclear medicine), radioactivity in your urine or intestines could give a moderate dose to the fetus, and some compounds can cross the placenta *Words in italics are defined in the Glossary on page 3.

Melissa Arch; At Immanuel St. Joseph’s

2010-01-01T23:59:59.000Z

127

Alterations in transcription factor binding in radioresistant human melanoma cells after ionizing radiation  

Science Conference Proceedings (OSTI)

We analyzed alterations in transcription factor binding to specific, known promoter DNA consensus sequences between irradiated and unirradiated radioresistant human melanoma (U1-Mel) cells. The goal of this study was to begin to investigate which transcription factors and DNA-binding sites are responsible for the induction of specific transcripts and proteins after ionizing radiation. Transcription factor binding was observed using DNA band-shift assays and oligonucleotide competition analyses. Confluence-arrested U1-Mel cells were irradiated (4.5 Gy) and harvested at 4 h. Double-stranded oligonucleotides containing known DNA-binding consensus sites for specific transcription factors were used. Increased DNA binding activity after ionizing radiation was noted with oligonucleotides containing the CREB, NF-kB and Sp1 consensus sites. No changes in protein binding to AP-1, AP-2, AP-3, or CTF/NF1, GRE or Oct-1 consensus sequences were noted. X-ray activation of select transcription factors, which bind certain consensus sites in promoters, may cause specific induction or repression of gene transcription. 22 refs., 2 figs.

Sahijdak, W.M.; Yang, Chin-Rang; Zuckerman, J.S.; Meyers, M.; Boothman, D.A. [Univ. of Wisconsin, Madison, WI (United States)

1994-04-01T23:59:59.000Z

128

Occupational Radiation Exposure Analysis of US ITER DCLL TBM  

Science Conference Proceedings (OSTI)

This report documents an Occupational Radiation Exposure (ORE) analysis that was performed for the US International Thermonuclear Experimental Reactor (ITER) Dual Coolant Lead Lithium (DCLL) Test Blanket Module (TBM). This analysis was performed with the QADMOD dose code for anticipated maintenance activities for this TBM concept and its ancillary systems. The QADMOD code was used to model the PbLi cooling loop of this TBM concept by specifying gamma ray source terms that simulated radioactive material within the piping, valves, heat exchanger, permeator, pump, drain tank, and cold trap of this cooling system. Estimates of the maintenance tasks that will have to be performed and the time required to perform these tasks where developed based on either expert opinion or on industrial maintenance experience for similar technologies. This report details the modeling activity and the calculated doses for the maintenance activities envisioned for the US DCLL TBM.

Merrill, Brad J; Cadwallader, Lee C; Dagher, Mohamad

2007-08-01T23:59:59.000Z

129

Examination system utilizing ionizing radiation and a flexible, miniature radiation detector probe  

DOE Patents (OSTI)

An optimized examination system and method based on the Reverse Geometry X-Ray.RTM. (RGX.RTM.) radiography technique are presented. The examination system comprises a radiation source, at least one flexible, miniature radiation detector probe positioned in appropriate proximity to the object to be examined and to the radiation source with the object located between the source and the probe, a photodetector device attachable to an end of the miniature radiation probe, and a control unit integrated with a display device connected to the photodetector device. The miniature radiation detector probe comprises a scintillation element, a flexible light guide having a first end optically coupled to the scintillation element and having a second end attachable to the photodetector device, and an opaque, environmentally-resistant sheath surrounding the flexible light guide. The probe may be portable and insertable, or may be fixed in place within the object to be examined. An enclosed, flexible, liquid light guide is also presented, which comprises a thin-walled flexible tube, a liquid, preferably mineral oil, contained within the tube, a scintillation element located at a first end of the tube, closures located at both ends of the tube, and an opaque, environmentally-resistant sheath surrounding the flexible tube. The examination system and method have applications in non-destructive material testing for voids, cracks, and corrosion, and may be used in areas containing hazardous materials. In addition, the system and method have applications for medical and dental imaging.

Majewski, Stanislaw (Grafton, VA); Kross, Brian J. (Yorktown, VA); Zorn, Carl J. (Yorktown, VA); Majewski, Lukasz A. (Grafton, VA)

1996-01-01T23:59:59.000Z

130

Examination system utilizing ionizing radiation and a flexible, miniature radiation detector probe  

DOE Patents (OSTI)

An optimized examination system and method based on the Reverse Geometry X-Ray{trademark} (RGX{trademark}) radiography technique are presented. The examination system comprises a radiation source, at least one flexible, miniature radiation detector probe positioned in appropriate proximity to the object to be examined and to the radiation source with the object located between the source and the probe, a photodetector device attachable to an end of the miniature radiation probe, and a control unit integrated with a display device connected to the photodetector device. The miniature radiation detector probe comprises a scintillation element, a flexible light guide having a first end optically coupled to the scintillation element and having a second end attachable to the photodetector device, and an opaque, environmentally-resistant sheath surrounding the flexible light guide. The probe may be portable and insertable, or may be fixed in place within the object to be examined. An enclosed, flexible, liquid light guide is also presented, which comprises a thin-walled flexible tube, a liquid, preferably mineral oil, contained within the tube, a scintillation element located at a first end of the tube, closures located at both ends of the tube, and an opaque, environmentally-resistant sheath surrounding the flexible tube. The examination system and method have applications in non-destructive material testing for voids, cracks, and corrosion, and may be used in areas containing hazardous materials. In addition, the system and method have applications for medical and dental imaging. 5 figs.

Majewski, S.; Kross, B.J.; Zorn, C.J.; Majewski, L.A.

1996-10-22T23:59:59.000Z

131

Development and characterization of acrylated palm oil nanoparticles using ionizing radiation  

SciTech Connect

In this study, the utilization of radiation crosslinking methods which are known as intermolecular and intramolecular crosslinking for the formation of nanoparticles of Acrylated Palm Oil (APO) in the microemulsion system that also consists of Pluronic F-127 (PF-127) surfactant was demonstrated. This microemulsion system was subjected to the ionizing radiation i.e. gamma irradiation at different doses to form the crosslinked APO nanoparticles. The effects of radiation doses on the size of APO nanoparticles were investigated using the Dynamic Light Scattering (DLS) method and their images were viewed using the Transmission Electron Microcrospy (TEM). The Fourier Transform Infra-Red (FTIR) spectroscopy was used to characterize the chemical structure and the crosslinking conversion of carbon-carbon double bond (-C = C-) of the APO nanoparticles after irradiation. As a result, the size of the APO nanoparticle decreased when the irradiation dose increased. Reduce in size might be due to the effect of intramolecular crosslinking reaction of the APO nanoparticles during irradiation process. Meanwhile, the intramolecular -C C- crosslinking conversion percentage was increased at doses below 1kGy before decreasing at the higher dose that might due to the intermolecular crosslinking of the macromolecules. This study showed that radiation crosslinking methods of polymerization and crosslinking in the microemulsion were found to be promising for the synthesis of nanoparticles.

Tajau, Rida; Yunus, Wan Md Zin Wan; Dahlan, Khairul Zaman Mohd; Mahmood, Mohd Hilmi; Hashim, Kamaruddin [Malaysian Nuclear Agency (Nuclear Malaysia), Radiation Processing Technology Division (BTS), Bangi, 43000 Kajang, Selangor (Malaysia); Chemistry Department, Faculty of Science, University Putra Malaysia (UPM), 43400 UPM Serdang, Selangor (Malaysia); Malaysian Nuclear Agency (Nuclear Malaysia), Radiation Processing Technology Division (BTS), Bangi, 43000 Kajang, Selangor (Malaysia)

2012-11-27T23:59:59.000Z

132

Cellular and molecular level responses after radiofrequency radiation exposure, alone or in combination with x-rays or chemicals. Final report, 1 April 1991-30 September 1994  

SciTech Connect

This project was initiated to explore the potential bioeffects of microwave radiation, alone or in combination with ionizing radiation and chemicals. Over the time period of the project, an automated thermal control system, to be used for maintaining the temperature in tissue culture medium during microwave exposures, was designed, constructed, and software was created. While this was underway during the project period, numerous positive control biological experiments were performed on two different cell types, the Epstein Barr Virus transformed 244B human lymphoblastoid cell, and the freshly isolated peripheral human lymphocyte. The 244B cells were used to address the question of whether a physical agent, ionizing radiation, at low doses where cells would predominantly remain viable, would induce the DNA binding protein NF-kB, and/or four immediate early genes (IEG) (protooncogenes).

Meltz, M.L.; Natarajan, M.; Prasad, A.V.

1995-02-21T23:59:59.000Z

133

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal  

NLE Websites -- All DOE Office Websites (Extended Search)

and HZE Particle Effects on Adult Hippocampal and HZE Particle Effects on Adult Hippocampal Neurogenesis and mRNA Expression Kerry O'Banion University of Rochester School of Medicine & Dentistry Abstract Most of our knowledge about low dose radiation effects relates to DNA damage and chromosomal aberrations that result in cell death or alterations in genetic programs leading to malignancy. In addition To direct DNA damage, there is accumulating evidence that radiation induced alterations in the microenvironment can have significant effects on programs of cell replication and differentiation such as neurogenesis in adult mammalian brain. Adult neurogenesis in the hippocampus is postulated to play an important role in learning and memory and manipulations that alter neurogenesis, including inhibition following radiation exposure, have been

134

Monitoring exposure to atomic bomb radiation by somatic mutation  

SciTech Connect

Atomic bomb survivors are a population suitable for studying the relationship between somatic mutation and cancer risk because their exposure doses are relatively well known and their dose responses in terms of cancer risk have also been thoroughly studied. An analysis has been made of erythrocyte glycophorin A (GPA) gene mutations in 1,226 atomic bomb survivors in Hiroshima and Nagasaki. The GPA mutation frequency (Mf) increased slightly but significantly with age at the time of measurement and with the number of cigarettes smoked. After adjustment for the effect of smoking, the Mf was significantly higher in males than in females and higher in Hiroshima than in Nagasaki. All of these characteristics of the background GPA Mf were in accord with those of solid tumor incidence obtained from an earlier epidemiological study of A-bomb survivors. Analysis of the dose effect on Mf revealed the doubling dose to be about 1.20 Sv and the minimum dose for detection of a significant increase to be about 0.24 Sv. No significant dose effect for difference in sex, city, or age at the time of bombing was observed. Interestingly, the doubling dose for the GPA Mf approximated that for solid cancer incidence (1.59 Sv). And the minimum dose for detection was not inconsistent with the data for solid cancer incidence. The dose effect was significantly higher in those diagnosed with cancer before or after measurement than in those without a history of cancer. These findings are consistent with the hypothesis that somatic mutations are the main cause of excess cancer risk from radiation exposure. 27 refs., 2 figs.

Akiyama, Mitoshi; Kyoizumi, Seishi; Kusunoki, Yoichiro [Radiation Effects Research Foundation, Hiroshima (Japan)] [and others

1996-05-01T23:59:59.000Z

135

TWO-DIMENSIONAL RADIATIVE MAGNETOHYDRODYNAMIC SIMULATIONS OF THE IMPORTANCE OF PARTIAL IONIZATION IN THE CHROMOSPHERE  

Science Conference Proceedings (OSTI)

The bulk of the solar chromosphere is weakly ionized and interactions between ionized particles and neutral particles likely have significant consequences for the thermodynamics of the chromospheric plasma. We investigate the importance of introducing neutral particles into the MHD equations using numerical 2.5D radiative MHD simulations obtained with the Bifrost code. The models span the solar atmosphere from the upper layers of the convection zone to the low corona, and solve the full MHD equations with non-gray and non-LTE radiative transfer, and thermal conduction along the magnetic field. The effects of partial ionization are implemented using the generalized Ohm's law, i.e., we consider the effects of the Hall term and ambipolar diffusion in the induction equation. The approximations required in going from three fluids to the generalized Ohm's law are tested in our simulations. The Ohmic diffusion, Hall term, and ambipolar diffusion show strong variations in the chromosphere. These strong variations of the various magnetic diffusivities are absent or significantly underestimated when, as has been common for these types of studies, using the semi-empirical VAL-C model as a basis for estimates. In addition, we find that differences in estimating the magnitude of ambipolar diffusion arise depending on which method is used to calculate the ion-neutral collision frequency. These differences cause uncertainties in the different magnetic diffusivity terms. In the chromosphere, we find that the ambipolar diffusion is of the same order of magnitude or even larger than the numerical diffusion used to stabilize our code. As a consequence, ambipolar diffusion produces a strong impact on the modeled atmosphere. Perhaps more importantly, it suggests that at least in the chromospheric domain, self-consistent simulations of the solar atmosphere driven by magnetoconvection can accurately describe the impact of the dominant form of resistivity, i.e., ambipolar diffusion. This suggests that such simulations may be more realistic in their approach to the lower solar atmosphere (which directly drives the coronal volume) than previously assumed.

Martinez-Sykora, Juan; De Pontieu, Bart; Hansteen, Viggo, E-mail: j.m.sykora@astro.uio.no [Lockheed Martin Solar and Astrophysics Laboratory, Palo Alto, CA 94304 (United States)

2012-07-10T23:59:59.000Z

136

Ionizing radiation risks to Satellite Power Systems (SPS) workers in space  

DOE Green Energy (OSTI)

A reference Satellite Power System (SPS) has been designed by NASA and its contractors for the purposes of evaluating the concept and carrying out assessments of the various consequences of development, including those on the health of the space workers. The Department of Energy has responsibility for directing various assessments. Present planning calls for the SPS workers to move from Earth to a low earth orbit (LEO) at an altitude of 500 kilometers; to travel by a transfer ellipse (TE) trajectory to a geosynchronous orbit (GEO) at an altitude of 36,000 kilometers; and to remain in GEO orbit for about 90 percent of the total time aloft. The radiation risks to the health of workers who will construct and maintain solar power satellites in the space environment are studied. The charge to the committee was: (a) to evaluate the radiation environment estimated for the Reference System which could represent a hazard; (b) to assess the possible somatic and genetic radiation hazards; and (c) to estimate the risks to the health of SPS workers due to space radiation exposure, and to make recommendations based on these conclusions. Details are presented. (WHK)

Not Available

1980-12-01T23:59:59.000Z

137

Ionization of Sodium and Rubidium nS, nP and nD Rydberg atoms by blackbody radiation  

E-Print Network (OSTI)

Results of theoretical calculations of ionization rates of Rb and Na Rydberg atoms by blackbody radiation (BBR) are presented. Calculations have been performed for nS, nP and nD states of Na and Rb, which are commonly used in a variety of experiments, at principal quantum numbers n=8-65 and at three ambient temperatures of 77, 300 and 600 K. A peculiarity of our calculations is that we take into account the contributions of BBR-induced redistribution of population between Rydberg states prior to photoionization and field ionization by extraction electric field pulses. The obtained results show that these phenomena affect both the magnitude of measured ionization rates and shapes of their dependencies on n. The calculated ionization rates are compared with the results of our earlier measurements of BBR-induced ionization rates of Na nS and nD Rydberg states with n=8-20 at 300 K. A good agreement for all states except nS with n>15 is observed. We also present the useful analytical formulae for quick estimation of BBR ionization rates of Rydberg atoms.

I. I. Beterov; D. B. Tretyakov; I. I. Ryabtsev; A. Ekers; N. N. Bezuglov

2007-02-22T23:59:59.000Z

138

Gaseous Radiochemical Method for Registration of Ionizing Radiation and Its Possible Applications in Science and Industry  

E-Print Network (OSTI)

This work presents a new possibility of registration of ionizing radiation by the flowing gaseous radiochemical method (FGRM). The specified method uses the property of some solid crystalline lattice materials for a free emission of radioactive isotopes of inert gas atoms formed as a result of nuclear reactions. Generated in an ampoule of the detector, the radioactive inert gases are transported by a gas-carrier into the proportional gas counter of the flowing type, where the decay rate of the radioactive gas species is measured. This quantity is unequivocally related to the flux of particles (neutrons, protons, light and heavy ions) at the location of the ampoule. The method was used to monitor the neutron flux of the pulsed neutron target "RADEX" driven by the linear proton accelerator of INR RAS. Further progress of the FGRM may give rise to possible applications in nuclear physics, astrophysics and medicine, in the nondestructive control of fissionable materials, diagnostics of thermonuclear plasma, monitoring of fluxes and measurement of spectra of bombarding particles.

S. G. Lebedev; V. E. Yants

2005-10-06T23:59:59.000Z

139

Ionizing radiation induces IL-6-production by human fibroblasts involving activation of nuclear factor-. kappa. B  

Science Conference Proceedings (OSTI)

The authors report that human lung fibroblasts respond to X-ray treatment with release of interleukin (IL) -6. Synthesis of IL-6 upon ionizing radiation is preceded by an increase of IL-6 transcript levels resulting from transcriptional activation of the IL-6 gene. Analysis of deleted fragments of the IL-6 promoter revealed that transcriptional induction of the IL-6 promoter is due to enhanced binding activity of the transcription factor NF-kB. Although AP-1 does not participate in the rapid induction of the IL-6 promoter its binding activity is also enhanced upon XRT. In contrast to binding kinetics observed with NF-kB, AP-1 binding upon XRT. In contrast to binding kinetics observed with NF-kB- and the AP-1 recognition sequence, conferred inducibility by XRT to a heterologous promoter, with reporter gene activity being maximal 24 hours or 48 hours upon XRT, respectively. Sequential activation of two distinct transcription factors might thus contribute to synchronize transcriptional activation of different genes participating in the X-ray response.

Brach, M.A.; Gruss, H.J.; Kaisho, Tsuneyasu; Asano, Yoshinobu; Vos, Sven de; Mertelsmann, R.; Hirano, Toshio; Herrmann, F. (Univ. of Freiburg (Germany) Osaka Univ. (Japan))

1992-02-26T23:59:59.000Z

140

Ionization of Sodium and Rubidium nS, nP and nD Rydberg atoms by blackbody radiation  

E-Print Network (OSTI)

Results of theoretical calculations of ionization rates of Rb and Na Rydberg atoms by blackbody radiation (BBR) are presented. Calculations have been performed for nS, nP and nD states of Na and Rb, which are commonly used in a variety of experiments, at principal quantum numbers n=8-65 and at three ambient temperatures of 77, 300 and 600 K. A peculiarity of our calculations is that we take into account the contributions of BBR-induced redistribution of population between Rydberg states prior to photoionization and field ionization by extraction electric field pulses. The obtained results show that these phenomena affect both the magnitude of measured ionization rates and shapes of their dependencies on n. The calculated ionization rates are compared with the results of our earlier measurements of BBR-induced ionization rates of Na nS and nD Rydberg states with n=8-20 at 300 K. A good agreement for all states except nS with n>15 is observed. We also present the useful analytical formulae for quick estimation ...

Beterov, I I; Ekers, A; Ryabtsev, I I; Tretyakov, D B

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

REGULATORY GUIDE 8.13 (Draft was issued as DG-8014) INSTRUCTION CONCERNING PRENATAL RADIATION EXPOSURE  

E-Print Network (OSTI)

Inspection and Investigations, ” in Section 19.12, “Instructions to Workers, ” requires instruction in “the health protection problems associated with exposure to radiation and/or radioactive material, in precautions or procedures to minimize exposure, and in the purposes and functions of protective devices employed. ” The

unknown authors

1999-01-01T23:59:59.000Z

142

ORISE: Illness and Injury Surveillance, Radiation Exposure, and...  

NLE Websites -- All DOE Office Websites (Extended Search)

Surveillance Data, December 2012 (PDF) Technical Report: Health Surveillance of Rocky Flats Radiation Workers, April 2006 (PDF) Technical Basis Document for the Neutron Dose...

143

Video Camera Use at Nuclear Power Plants: Tools for Increasing Productivity and Reducing Radiation Exposure: Tools for Increasing Pr oductivity and Reducing Radiation Exposure  

Science Conference Proceedings (OSTI)

Nuclear power plants have increased the use of industrial video cameras as support tools for a variety of plant operations and outage tasks. This survey on utility use of video cameras, the equipment being used, and the benefits derived found that the video camera is an important tool for reducing radiation exposure and improving productivity through more efficient use of personnel.

1990-08-14T23:59:59.000Z

144

Literature Highlight: Radiation Exposure to the Heart and the Risk of Ischemic Heart Disease  

E-Print Network (OSTI)

, fish, and olive oil.1-4 This diet discourages dairy products, saturated fats, and red meats.1-4 Older have helped to limit radiation exposure to unaffected tissues, radiation expo- sure to the heart may benefit from an -linolenic acid-rich Mediterranean diet which emphasizes bread, fruits, nuts, vegetables

Vonessen, Nikolaus

145

European Integrated Project RISC-RAD Radiosensitivity of Individuals and Susceptibility to Cancer induced by Ionizing Radiations  

NLE Websites -- All DOE Office Websites (Extended Search)

Integrated Project RISC-RAD Integrated Project RISC-RAD Radiosensitivity of Individuals and Susceptibility to Cancer induced by Ionizing Radiations Laure Sabatier 1 , L.H.F Mullenders 2 , Mike Atkinson 3 , Simon Bouffler 4 , Herwig Paretzke 5 1 Laboratory of Radiobiology and Oncology, CEA, 18 route du panorama BP6 92265 Fontenay-aux- Roses, France 2 LUMC, Department of Toxicogenetics, Postal Zone S-4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands 3 GSF- Institute of Pathology, Ingolstädter Landstrasse 1, 85764 Neuherberg Germany 4 HPA Radiation Protection Division, Centre for Radiation Chemical and Environmental Hazards, Chilton, UK 5 GSF- Institute of Radiation Protection, Ingolstädter Landstrasse 1, Neuherberg, D-85764 Germany In radiological protection, the risks of inducing stochastic health effects (largely cancer) by a

146

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  

SciTech Connect

Purpose: Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damage sensor ataxia-telangiectasia mutated (ATM). We explored the regulation of AMPK by ionizing radiation (IR) and its role as a target for radiosensitization of human cancer cells. Methods and Materials: Lung, prostate, and breast cancer cells were treated with IR (2-8 Gy) after incubation with either ATM or AMPK inhibitors or the AMPK activator metformin. Then, cells were subjected to either lysis and immunoblotting, immunofluorescence microscopy, clonogenic survival assays, or cell cycle analysis. Results: IR induced a robust phosphorylation and activation of AMPK in all tumor cells, independent of LKB1. IR activated AMPK first in the nucleus, and this extended later into cytoplasm. The ATM inhibitor KU-55933 blocked IR activation of AMPK. AMPK inhibition with Compound C or anti-AMPK {alpha} subunit small interfering RNA (siRNA) blocked IR induction of the cell cycle regulators p53 and p21{sup waf/cip} as well as the IR-induced G2/M arrest. Compound C caused resistance to IR, increasing the surviving fraction after 2 Gy, but the anti-diabetic drug metformin enhanced IR activation of AMPK and lowered the surviving fraction after 2 Gy further. Conclusions: We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21{sup waf/cip} and regulation of the cell cycle and survival. AMPK appears to (1) participate in an ATM-AMPK-p21{sup waf/cip} pathway, (2) be involved in regulation of the IR-induced G2/M checkpoint, and (3) may be targeted by metformin to enhance IR responses.

Sanli, Toran; Rashid, Ayesha; Liu Caiqiong [Department of Oncology, Juravinski Cancer Center and McMaster University, Hamilton, Ontario (Canada)

2010-09-01T23:59:59.000Z

147

Radiation and Uranium Resources Exposure Control (South Dakota)  

Energy.gov (U.S. Department of Energy (DOE))

The public policy of South Dakota is to encourage the constructive uses of radiation, the proper development of uranium resources, and the control of any associated harmful effects. The disposal of...

148

Risk equivalent of exposure versus dose of radiation  

SciTech Connect

This report describes a risk analysis study of low-dose irradiation and the resulting biological effects on a cell. The author describes fundamental differences between the effects of high-level exposure (HLE) and low-level exposure (LLE). He stresses that the concept of absorbed dose to an organ is not a dose but a level of effect produced by a particular number of particles. He discusses the confusion between a linear-proportional representation of dose limits and a threshold-curvilinear representation, suggesting that a LLE is a composite of both systems. (TEM)

Bond, V.P.

1986-01-01T23:59:59.000Z

149

Assessment of potential radiation exposures by uncontrolled recycle or reuse of radioactive scrap metals  

Science Conference Proceedings (OSTI)

With current waste monitoring technology it is reasonable to assume that much of the material designated as low-level waste, generated within nuclear facilities, is in fact uncontaminated. A criterion for uncontrolled disposal of low-level radioactive contaminated waste is that the radiation exposure of the public and of each individual caused by this disposal is so low that radiation protection measures need not be taken. The International Atomic Energy Agency (IAEA) suggests an annual effective dose of 10 {micro}Sv as a limit for the individual radiation dose and derived the initial control levels of residual radioactivity based on the Publication 30 of the International Commission on Radiological Protection (ICRP). In 1990, new recommendations on radiation protection standards were developed by ICRP to take into account new biological information related to the detriment associated with radiation exposure. Adoption of these recommendations necessitated a revision of the Commission's secondary limits contained in Publication 30. This study summarizes the potential radiation exposure from valuable scrap metal considered for uncontrolled recycle by new ICRP recommendations. Potential exposure pathways to people were analyzed and concentrations leading to an individual dose of 10 {micro}Sv/year were calculated for 14 key radionuclides. These potential radiation doses are compared with the results of previous study.

Lee, S.Y.; Lee, K.J.

1999-07-01T23:59:59.000Z

150

Body radiation exposure in breast cancer radiotherapy: Impact of breast IMRT and virtual wedge compensation techniques  

Science Conference Proceedings (OSTI)

Purpose: Recent reports demonstrate a dramatically increased rate of secondary leukemia for breast cancer patients receiving adjuvant high-dose anthracycline and radiotherapy, and that radiation is an independent factor for the development of leukemia. This study aimed to evaluate the radiation body exposure during breast radiotherapy and to characterize the factors associated with an increased exposure. Patients and Methods: In a prospective cohort of 120 women, radiation measurements were taken from four sites on the body at the time of adjuvant breast radiotherapy. Multiple regression analysis was performed to analyze patient and treatment factors associated with the amount of scattered radiation. Results: For standard 50 Gy breast radiotherapy, the minimal dose received by abdominal organs is on average 0.45 Gy, ranging from 0.06 to 1.55 Gy. The use of physical wedges as a compensation technique was the most significant factor associated with increased scattered dose (p < 0.001), resulting in approximately three times more exposure compared with breast intensity-modulated radiation therapy (IMRT) and dynamic wedge. Conclusions: The amount of radiation that is scattered to a patient's body is consistent with exposure reported to be associated with excess of leukemia. In accordance with the As Low As Reasonably Achievable (ALARA) principle, we recommend using breast IMRT or virtual wedging for the radiotherapy of breast cancer receiving high-dose anthracycline chemotherapy.

Woo, Tony [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Pignol, Jean-Philippe [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada)]. E-mail: Jean-Philippe.Pignol@sw.ca; Rakovitch, Eileen [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Vu, Toni [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Hicks, Deanna [Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); O'Brien, Peter [Department of Medical Physics, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada); Pritchard, Kathleen [Department of Medical Oncology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario (Canada)

2006-05-01T23:59:59.000Z

151

Light scattering apparatus and method for determining radiation exposure to plastic detectors  

DOE Patents (OSTI)

An improved system and method of analyzing cumulative radiation exposure registered as pits on track etch foils of radiation dosimeters. The light scattering apparatus and method of the present invention increases the speed of analysis while it also provides the ability to analyze exposure levels beyond that which may be properly measured with conventional techniques. Dosimeters often contain small plastic sheets that register accumulated damage when exposed to a radiation source. When the plastic sheet from the dosimeter is chemically etched, a track etch foil is produced wherein pits or holes are created in the plastic. The number of these pits, or holes, per unit of area (pit density) correspond to the amount of cumulative radiation exposure which is being optically measured by the apparatus. To measure the cumulative radiation exposure of a track etch foil a high intensity collimated beam is passed through foil such that the pits and holes within the track etch foil cause a portion of the impinging light beam to become scattered upon exit. The scattered light is focused with a lens, while the primary collimated light beam (unscattered light) is blocked. The scattered light is focused by the lens onto an optical detector capable of registering the optical power of the scattered light which corresponds to the cumulative radiation to which the track etch foil has been exposed.

Hermes, Robert E. (White Rock, NM)

2002-01-01T23:59:59.000Z

152

IONIZATION CHAMBER  

DOE Patents (OSTI)

This patent describes a novel ionization chamber which is well suited to measuring the radioactivity of the various portions of a wire as the wire is moved at a uniform speed, in order to produce the neutron flux traverse pattern of a reactor in which the wire was previously exposed to neutron radiation. The ionization chamber of the present invention is characterized by the construction wherein the wire is passed through a tubular, straight electrode and radiation shielding material is disposed along the wire except at an intermediate, narrow area where the second electrode of the chamber is located.

Redman, W.C.; Shonka, F.R.

1958-02-18T23:59:59.000Z

153

Raman spectroscopy of tumour cells exposed to clinically relevant doses of ionizing radiation.  

E-Print Network (OSTI)

??Improvements to radiation therapy treatment outcomes rely, in part, on consideration of patient specific radiosensitivity. Therefore an assay which quantifies radiation-induced biochemical changes, and subsequently… (more)

Harder, Samantha

2013-01-01T23:59:59.000Z

154

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

155

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

156

Increased radiation dose at mammography due to prolonged exposure, delayed processing, and increased film darkening  

SciTech Connect

Four single-emulsion films introduced over the past 2 years--Du Pont Microvision, Fuji MiMa, Konica CM, and Eastman Kodak OM--were compared with Eastman Kodak OM SO-177 (Min-RE) film to evaluate their varying effects on mean glandular dose of reciprocity law failure due to prolonged exposure, delayed processing, and increased film darkening as a result of increased radiation exposure to improve penetration of glandular tissue. Exposures over 1.3 seconds led to increased radiation doses of 20%-30%. Delays in processing of 6 hours decreased processing speed by 11%-32% for all films except Du Pont Microvision. Optical density increases of 0.40 required 20%-30% more skin exposure for all five films. Optimal viewing densities were also evaluated and found to be different for each of the five films. Mammographers need to be aware of these differences in mammographic films to achieve maximum contrast at mammography.

Kimme-Smith, C.; Bassett, L.W.; Gold, R.H.; Chow, S. (UCLA Medical Center (USA))

1991-02-01T23:59:59.000Z

157

Occupational radiation exposure history of Idaho Field Office Operations at the INEL  

Science Conference Proceedings (OSTI)

An extensive review has been made of the occupational radiation exposure records of workers at the Idaho National Engineering Laboratory (INEL) over the period of 1951 through 1990. The focus has been on workers employed by contractors and employees of the Idaho Field Operations Office (ID) of the United States Department of Energy (USDOE) and does not include the Naval Reactors Facility (NRF), the Argonne National Laboratory (ANL), or other operations field offices at the INEL. The radiation protection guides have decreased from 15 rem/year to 5 rem/year in 1990 for whole body penetrating radiation exposure. During these 40 years of nuclear operations (in excess of 200,000 man-years of work), a total of twelve individuals involved in four accidents exceeded the annual guidelines for exposure; nine of these exposures were received during life saving efforts on January 3, 1961 following the SL-1 reactor accident which killed three military personnel. These exposures ranged from 8 to 27 rem. Only one individual has exceeded the annual whole body penetrating radiation protection guidelines in the last 29 years.

Horan, J.R.; Braun, J.B.

1993-10-01T23:59:59.000Z

158

Measurement of environmental radiation exposure rates from Vernita, Hanford Reach, and Richland area shores. Addendum 1  

SciTech Connect

Environmental radiation exposure rate measurements are taken on and around the Hanford Site for Pacific Northwest Laboratory`s Hanford Site Surface Environmental Surveillance Project. In 1992, environmental radiation exposure rate measurements were taken from shoreline and island areas ranging from Vernita, along the Hanford Reach, down to the Richland Pumphouse. Measurements were taken primarily at locations known or expected to have elevated exposure rates as determined by examination of aerial photographs depicting radiation exposure measurements. Results from the 1992 survey indicated radiation exposure rates taken from the Hanford Reach area were elevated in comparison to the measurements taken from the Vernita area with ranges of 8 to 28 {mu}R/hr and 4 to 11 {mu}R/hr, respectively. In January 1994, additional shoreline radiation exposure rate measurements were taken from the Vernita, Hanford Reach, and Richland areas to determine the relationship of radiation exposure rates along the Richland area shores when compared to Vernita and Hanford Reach area exposure rates (measurements along the Richland area were not collected during the 1992 survey). This report discusses the 1994 results and is an addendum to the report that discussed the 1992 survey. An analysis of variance indicated a significant location interaction at a p-value of 0.0014. To determine differences between paried locations a post-hoc comparison of location means was performed on log transformed data using the Scheff{acute e}`s F-test. This test indicated a significant difference between Hanford Reach and Richland area means with a mean difference of 0.075 /{mu}R/hr and a p-value of 0.0014. No significant difference was found between Hanford Reach and Vernita area means: The mean difference was 0.031 {mu}R/hr and the p-value was 0.3138. No significant difference was found between Vernita and Richland area means with a mean difference of 0.044 {mu}R/hr and a p-value of 0.1155.

Cooper, A.T.

1995-02-01T23:59:59.000Z

159

Occupational Radiation Exposure at Commercial Nuclear Power Reactors and Other Facilities 2008  

Science Conference Proceedings (OSTI)

This report summarizes the occupational exposure data that are maintained in the U.S. Nuclear Regulatory Commission (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 2008 annual reports submitted by five of the seven categories1 of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. The annual reports submitted by these licensees consist of radiation exposure records for each monitored individual. These records are analyzed for trends and presented in this report in terms of collective dose and the distribution of dose among the monitored individuals. Because there are no geologic repositories for high-level waste currently licensed and no low-level waste disposal facilities in operation, only five categories will be considered in this report.

U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research

2009-12-01T23:59:59.000Z

160

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of Atomic Bomb Radiation Effects Life Span Study Report 8.reports derive mainly from the epidemiological studies of the Japanese atomic bomb

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Non-Targeted Effects of Low Dose Ionizing Radiation Act Via TGFβ...  

NLE Websites -- All DOE Office Websites (Extended Search)

effect that mediates microenvironment composition. TGF is activated in mouse mammary gland following whole body exposure to doses of as low as 0.1 Gy and persists in the stroma...

162

Ionization chamber  

DOE Patents (OSTI)

An ionization chamber has separate drift and detection regions electrically isolated from each other by a fine wire grid. A relatively weak electric field can be maintained in the drift region when the grid and another electrode in the chamber are connected to a high voltage source. A much stronger electric field can be provided in the detection region by connecting wire electrodes therein to another high voltage source. The detection region can thus be operated in a proportional mode when a suitable gas is contained in the chamber. High resolution output pulse waveforms are provided across a resistor connected to the detection region anode, after ionizing radiation enters the drift region and ionize the gas.

Walenta, Albert H. (Port Jefferson Station, NY)

1981-01-01T23:59:59.000Z

163

On the Use of SRIM/TRIM for Computing Radiation Damage Exposure  

SciTech Connect

The SRIM (formerly TRIM) Monte Carlo simulation code is widely used to compute a number of parameters relevant to ion beam implantation and ion beam processing of materials. It also has the capability to compute a common radiation damage exposure unit known as atomic displacements per atom (dpa). Since dpa is a standard measure of primary radiation damage production, most researchers who employ ion beams as a tool for inducing radiation damage in materials use SRIM to determine the dpa associated with their irradiations. The use of SRIM for this purpose has been evaluated and comparisons with an internationally-recognized standard definition of dpa, as well as more detailed atomistic simulations of atomic displacement cascades have been made. Differences between the standard and SRIM-based dpa are discussed and recommendations for future usage of SRIM in radiation damage studies are made.

Stoller, Roger E [ORNL; Toloczko, M [Pacific Northwest National Laboratory (PNNL); Was, Gary [University of Michigan; Certain, Alicia [Pacific Northwest National Laboratory (PNNL); Dwaraknath, Shyam [University of Michigan

2013-01-01T23:59:59.000Z

164

Spectral energy distribution of the metagalactic ionizing radiation field from QSO absorption spectra  

E-Print Network (OSTI)

A computational procedure is presented to estimate the spectral shape of the ionizing background between 1 and 10 Ryd by analyzing optically thin absorption systems in the spectra of high redshift quasars. The procedure is based on the response surface methodology from the theory of experimental design. The shape of the recovered UV background at z~3 shows a significant intensity decrease between 3 and 4 Ryd compared to the metagalactic spectrum of Haardt & Madau (1996). This decrease is interpreted as produced by HeII Gunn-Peterson effect. There are no features indicating a contribution from galaxies to the UV background which is therefore dominated by QSOs at z~3.

I. I. Agafonova; M. Centurion; S. A. Levshakov; P. Molaro

2005-06-07T23:59:59.000Z

165

Radiation Protection at Industrial Radiography in Germany Exposures and Unusual Events  

E-Print Network (OSTI)

Abstract. In the Federal Republic of Germany safety related events in the use and transportation of radioactive materials as well as in the operation of accelerators are registered. The analysis of these events reveals their causation and allows this conclusions on avoidable errors. In this paper, a special insight is given into events in the field of gamma radiography which is a technical application of ionising radiation for non destructive testing of materials. Conclusions from analysis are drawn. In addition, the occupational radiation exposure of workers is presented taking into account that industrial radiography is performed under particular working conditions with different risks. 1.

Renate Czarwinski; Uwe Häusler; Gerhard Frasch; Bundesamt Für; Strahlenschutz Fachbereich Strahlenschutz Und Gesundheit

2006-01-01T23:59:59.000Z

166

Comparison of radon fluxes with gamma-radiation exposure rates and soil /sup 226/Ra concentrations  

Science Conference Proceedings (OSTI)

Radon fluxes and contact gamma-radiation-exposure rates were measured at the grid points of rectangular grids on three properties in Edgemont, South Dakota that were known to have deposits of residual radioactivity relatively near to the surface. The coefficient of determination, r/sup 2/, between the radon fluxes and the contact gamma-radiation-exposure rates varied from 0.89 to 0.31 for the three properties. The property having the highest fluxes and residual radioactivity of relatively uniform depth showed the highest correlation between fluxes and exposure rates, and the property having residual radioactivity that varied considerably in depth showed the lowest. Correlations between fluxes and /sup 226/Ra concentrations measured in boreholes that varied in depth from 60 to 195 cm were lower than those between fluxes and exposure rates, indicating that exposure rates are better than /sup 226/Ra measurements for detecting elevated radon fluxes from near-surface deposits. Measurements made on one property at two different times indicated that if the average flux were determined from a large number (40) of measurements at one time, the average flux at a later time could be estimated from a few measurements using the assumption that the change in the flux at individual locations will be equal to the change in the average flux. Flux measurements around two buildings showing elevated indoor radon-daughter concentrations, but around which no residual radioactivity had been discovered by /sup 226/Ra and gamma-radiation measurements, provided no clear indication of the presence of such material, possibly because none was present.

Young, J.A.; Thomas, V.W.

1984-04-01T23:59:59.000Z

167

Low Dose Radiation Research Program: James D. Tucker  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of the Adaptive Response in determining health risks from in vivo exposures to low dose of ionizing radiation Tucker, J. Publications Christian, A.T., Patte, M.S., Attix,...

168

Individual Radiation Exposure Dose Due to Support Activities at Safe Shelters in Fukushima Prefecture  

E-Print Network (OSTI)

Immediately after the accidents in the nuclear power stations in Fukushima on March 11, the Japanese Government ordered the evacuation of the residents within a 20-km radius from the station on March 12, and asked various institutions to monitor the contamination levels of the residents. Hirosaki University, which is located 355 km north of Fukushima City, decided to send support staff to Fukushima. This report summarizes the results of the exposure of 13 individual teams from March 15 to June 20. The support teams surveyed more than 5,000 people during this period. Almost all subjects had external contamination levels of less than 13 kcpm on Geiger-Müller (GM) survey meter, which is categorized as ‘‘no contamination level.’ ’ The 1 st team showed the highest external exposure dose, but the 4 th team onward showed no significant change. Subsequently, the internal radiation exposure was measured using a whole body counter that indicated undetectable levels in all staff members. Although the measured external radiation exposure dose cannot have serious biological effects on the health of an individual, a follow-up study of the residents in Fukushima and other regions where

Satoru Monzen; Masahiro Hosoda; Shinji Tokonami; Minoru Osanai; Hironori Yoshino; Mitsuaki A. Yoshida; Masatoshi Yamada; Yasushi Asari; Kei Satoh; Ikuo Kashiwakura

2011-01-01T23:59:59.000Z

169

Assessing risks from occupational exposure to low-level radiation: The statistician's role  

SciTech Connect

Currently, several epidemiological studies of workers who have been exposed occupationally to radiation are being conducted. These include workers in the United States, Great Britain, and Canada, involved in the production of both defense materials and nuclear power. A major reason for conducting these studies is to evaluate possible adverse health effects that may have resulted because of the radiation exposure received. The general subject of health effects resulting from low levels of radiation, including these worker studies, has attracted the attention of various news media, and has been the subject of considerable controversy. These studies provide a good illustration of certain other aspects of the statistician's role; namely, communication and adequate subject matter knowledge. A competent technical job is not sufficient if these other aspects are not fulfilled.

Gilbert, E.S.

1989-06-01T23:59:59.000Z

170

Fundamentals of Radiation Dosimetry  

Science Conference Proceedings (OSTI)

The basic concepts of radiation dosimetry are reviewed on basis of ICRU reports and text books. The radiation field is described with, among others, the particle fluence. Cross sections for indirectly ionizing radiation are defined and indicated is how they are related to the mass energy transfer and mass energy absorption coefficients. Definitions of total and restricted mass stopping powers of directly ionizing radiation are given. The dosimetric quantities, kerma, absorbed dose and exposure together with the relations between them are discussed in depth. Finally it is indicated how the absorbed dose can be measured with a calorimeter by measuring the temperature increase and with an ionisation chamber measuring the charge produced by the ionizing radiation and making use of the Bragg-Gray relation.

Bos, Adrie J. J. [Delft University of Technology, Faculty of Applied Sciences, Mekelweg 15, 2629JB Delft (Netherlands)

2011-05-05T23:59:59.000Z

171

A molecular dynamics simulation of DNA damage induction by ionizing radiation  

E-Print Network (OSTI)

We present a multi-scale simulation of early stage of DNA damages by the indirect action of hydroxyl ($^\\bullet$OH) free radicals generated by electrons and protons. The computational method comprises of interfacing the Geant4-DNA Monte Carlo with the ReaxFF molecular dynamics software. A clustering method was employed to map the coordinates of $^\\bullet$OH-radicals extracted from the ionization track-structures onto nano-meter simulation voxels filled with DNA and water molecules. The molecular dynamics simulation provides the time evolution and chemical reactions in individual simulation voxels as well as the energy-landscape accounted for the DNA-$^\\bullet$OH chemical reaction that is essential for the first principle enumeration of hydrogen abstractions, chemical bond breaks, and DNA-lesions induced by collection of ions in clusters less than the critical dimension which is approximately 2-3 \\AA. We show that the formation of broken bonds leads to DNA base and backbone damages that collectively propagate ...

Abolfath, Ramin M; Chen, Zhe J; Nath, Ravinder

2013-01-01T23:59:59.000Z

172

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

SciTech Connect

Human mesenchymal stem cells (hMSC) are critical for tissue regeneration. How hMSC respond to genotoxic stresses and potentially contribute to aging and cancer remain underexplored. We demonstrated that ionizing radiation induced cellular senescence of hMSC over a period of 10 days, showing a critical transition between day 3 and day 6. This was confirmed by senescence-associated beta-galactosidase (SA-{beta}-gal) staining, protein expression profiles of key cell cycle regulators (retinoblastoma (Rb) protein, p53, p21{sup waf1/Cip1}, and p16{sup INK4A}), and senescence-associated secretory phenotypes (SASPs) (IL-8, IL-12, GRO, and MDC). We observed dramatic cytoskeletal reorganization of hMSC through reduction of myosin-10, redistribution of myosin-9, and secretion of profilin-1. Using a SILAC-based phosphoproteomics method, we detected significant reduction of myosin-9 phosphorylation at Ser1943, coinciding with its redistribution. Importantly, through treatment with cell permeable inhibitors (4,5,6,7-tetrabromo-1H-benzotriazole (TBB) and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT)), and gene knockdown using RNA interference, we identified CK2, a kinase responsible for myosin-9 phosphorylation at Ser1943, as a key factor contributing to the radiation-induced senescence of hMSC. We showed that individual knockdown of CK2 catalytic subunits CK2{alpha} and CK2{alpha}{prime} induced hMSC senescence. However, only knockdown of CK2{alpha} resulted in morphological phenotypes resembling those of radiation-induced senescence. These results suggest that CK2{alpha} and CK2{alpha}{prime} play differential roles in hMSC senescence progression, and their relative expression might represent a novel regulatory mechanism for CK2 activity.

Wang, Daojing; Jang, Deok-Jin

2009-08-21T23:59:59.000Z

173

Reduction of Carbon Dioxide inAqueous Solutions by IonizingRadiation  

DOE Green Energy (OSTI)

The question of the conditions under which living matter originated on the surface of the earth is still a subject limited largely to speculation. The speculation has a greater chance of approaching the truth insofar as it includes and is based upon the ever wider variety of established scientific fact. One of the purposes of the herein reported observation was to add another fact to the ever increasing information which might have any bearing upon this most interesting question. It is not our purpose in the present communication to discuss the various proposals or the arguments which have been adduced for and against them. One of the most popular current conceptions is that life originated in an organic milieu on the surface of the earth, (1,2,3,4,5). The problem to which we are addressed is the origin of that organic milieu in the absence of any life. It appeared to us that one source, if not the only source, of reduced carbon compounds in complex arrangements might be the interaction of various high energy radiations with aqueous solutions of inorganic materials, particularly carbon dioxide, and nitrogenous compounds such as ammonia and nitrogen, since it appears that these compounds were the commoner forms in which the essential elements found themselves on the primordial earth. While it has long been known that high energy radiations can cause organic decomposition and oxidation, it seemed useful to us to demonstrate that conditions could be found in which high energy radiations could induce the reduction with water of carbon dioxide and the ultimate creation of polyatomic molecules (other than simple polymerization of monomers) of carbon, oxygen, hydrogen and nitrogen.

Garrison, W.M.; Morrison, D.C.; Hamilton, J.G.; Benson, A.A.; Calvin, M.

1951-03-13T23:59:59.000Z

174

A Review of the European Union's Directive on Limiting Exposure of Workers to Electromagnetic Fields  

Science Conference Proceedings (OSTI)

The European Union’s Directive on Limiting Exposure of Workers to Electromagnetic Fields (EMF) adopts exposure limits based on guidance from the International Commission on Non-Ionizing Radiation Protection (ICNIRP). This report presents a summary of the draft Directive concerning workplace exposure limits and compliance issues. The summary explains quantitative EMF exposure limits in general and clarifies the Directive’s use of the terms exposure limit values (ELV) and action ...

2013-06-05T23:59:59.000Z

175

Low Dose Radiation Research Program: Impact of Genetic Factors on the  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic Factors on the Heritable Effects of Paternal Exposure to Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Janet E. Baulch University of California, Davis Why This Project? There is concern about the possible genetic effects of low dose radiation exposure. As a result, much effort has gone towards understanding mutation of cells due to radiation exposure. While recognition of the potential for mutation from exposure to ionizing radiation has led to extensive research, less effort has been given to the possible delayed risk of radiation exposure transmitted to the offspring of the exposed parent. Data from animal models show that parental exposures to DNA-damaging agents, such as ionizing radiation, predispose the offspring to serious health effects, including cancer offspring. Additionally, data from both humans and animal

176

Measuring Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Measurement Activity SI Units and Prefixes Conversions Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration...

177

Health Risks Associated with Low Doses of Radiation  

Science Conference Proceedings (OSTI)

Despite a wealth of information, there remains uncertainty concerning human radiation effects at low dose levels. This report provides background information and a literature review of research on the potential health hazards associated with exposure to low-level ionizing radiation. Topics include radiation characteristics, protection standards, epidemiologic data and risk models, the nature of human health exposure-related effects, important radiation health studies to date, and the scientific method fo...

1994-09-17T23:59:59.000Z

178

Review Article: Physics and Monte Carlo Techniques as Relevant to Cryogenic, Phonon and Ionization Readout of CDMS Radiation-Detectors  

E-Print Network (OSTI)

This review discusses detector physics and Monte Carlo techniques for cryogenic, radiation detectors that utilize combined phonon and ionization readout. A general review of cryogenic phonon and charge transport is provided along with specific details of the Cryogenic Dark Matter Search detector instrumentation. In particular this review covers quasidiffusive phonon transport, which includes phonon focusing, anharmonic decay and isotope scattering. The interaction of phonons in the detector surface is discussed along with the downconversion of phonons in superconducting films. The charge transport physics include a mass tensor which results from the crystal band structure and is modeled with a Herring Vogt transformation. Charge scattering processes involve the creation of Neganov-Luke phonons. Transition-edge-sensor (TES) simulations include a full electric circuit description and all thermal processes including Joule heating, cooling to the substrate and thermal diffusion within the TES, the latter of which is necessary to model normal-superconducting phase separation. Relevant numerical constants are provided for these physical processes in germanium, silicon, aluminum and tungsten. Random number sampling methods including inverse cumulative distribution function (CDF) and rejection techniques are reviewed. To improve the efficiency of charge transport modeling, an additional second order inverse CDF method is developed here along with an efficient barycentric coordinate sampling method of electric fields. Results are provided in a manner that is convenient for use in Monte Carlo and references are provided for validation of these models.

S. W. Leman

2011-09-06T23:59:59.000Z

179

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary glandas a means of understanding human risk for breast cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

susceptibility to low-dose ionizing radiation in the mouse mammary gland susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders 1 , Francesco Marchetti 1 , Ju Han 1 , Sandhya Bhatnagar 1 , Nadire Duru 1 , Zhi Hu 1 , Jian-Hua Mao 1 , Mina Bissell 1 , Joe Gray 1,2 , Gary H. Karpen 1 , Priscilla K. Cooper 1 and Andrew J. Wyrobek 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 Current affiliation: Biomedical Engineering, Oregon Health Science Univ, Portland, OR Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer.

180

The carcinogenic risks of low-LET and high-LET ionizing radiations  

SciTech Connect

New information is available concerning the carcinogenic effects of radiation and the implications for risk assessment and risk management. This information comes from further follow-up of the epidemiological studies of the Japanese atomic bomb survivors, patients irradiated medically for cancer and allied conditions, and workers exposed in various occupations. In the Japanese atomic bomb survivors the carcinogenic risks are estimated to be somewhat higher than previously, due to the reassessment of the atomic-bomb dosimetry, further follow-up with increase in the number of excess cancer deaths, particularly in survivors irradiated early in life, and changes in the methods of analysis to compute the age-specific risks of cancer. Because of the characteristics of the atomic bomb survivor series as regards sample size, age and sex distribution, duration for follow-up, person-years at risk, and type of dosimetry, the mortality experience of the atomic bomb survivors was selected by the UNSCEAR Committee and the BEIR V Committee as the more appropriate basis for projecting risk estimates for the general population. In the atomic bomb survivors, the dose-effect relationship for overall cancer mortality other than leukemia is consistent with linearity below 3 Gy, while the dose-effect relationship for leukemia, excluding chronic lymphatic leukemia, conforms best to a linear-quadratic function. The shape of the dose-incidence curve at low doses still remains uncertain, and the data do not rule out the possible existence of a threshold for an neoplasm. The excess relative risk of mortality from all cancers combined is estimated to be 1.39 per Gy (shielded kerma), which corresponds to an absolute risk of 10.0 excess cancer deaths per 10,000 PYGy; the relative risks is 1.41 at 1 Gy (organ-absorbed dose), and an absolute risk of 13.07 excess cancer deaths per 10,000 PYGy. 19 refs.

Fabrikant, J.I. (Lawrence Berkeley Lab., CA (USA))

1989-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Low Dose Radiation Program: Radiation Biology and the Radiation Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and the Radiation Research Program Biology and the Radiation Research Program The Department of Energy (DOE) and its predecessor organizations, Energy Research and Development Agency (ERDA) and Atomic Energy Commission (AEC), always have been concerned about the health effects of ionizing radiation. Extensive research has been conducted under their sponsorship at all levels of biological organization from molecules to man. Over the past 60 years, studies using every type of radiation source have included exposure to both external radiation sources and to internally deposited radioactive materials. These exposures used different dose patterns and distributions delivered over a wide range of experimental times. This extensive research provided the basis for the new Low Dose Radiation Research Program, linking

182

Radiation effects on humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

183

Safety Around Sources of Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Keeping Exposure Low Keeping Exposure Low Working Safely Around Radioactive Contamination Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Is it safe to be around sources? Too much radiation exposure is harmful. The degree of radiation injury depends on the amount of radiation received and the time involved. In general, the higher the amount, the greater the severity of early effects (occurring within a few weeks) and the greater the possibility of late effects such as cancer. The BEIR V (Biological Effects of Ionizing Radiation) Committee of the National Research Council estimates that among 100,000 people exposed to a one-time dose of 10 rem (10,000 mrem) and followed over their life span, about 790 more would die of cancer than the estimated 20,000 cancer deaths that would be expected among a non-exposed group of the same size. NOTE: 10 rem = 100 millisieverts (100 mSv).

184

Solar Radiation and Tidal Exposure as Environmental Drivers of Enhalus acoroides Dominated Seagrass  

E-Print Network (OSTI)

There is strong evidence of a global long-term decline in seagrass meadows that is widely attributed to anthropogenic activity. Yet in many regions, attributing these changes to actual activities is difficult, as there exists limited understanding of the natural processes that can influence these valuable ecosystem service providers. Being able to separate natural from anthropogenic causes of seagrass change is important for developing strategies that effectively mitigate and manage anthropogenic impacts on seagrass, and promote coastal ecosystems resilient to future environmental change. The present study investigated the influence of environmental and climate related factors on seagrass biomass in a large solar radiation. This study documents how natural long-term tidal variability can influence long-term seagrass dynamics. Exposure to desiccation, high UV, and daytime temperature regimes are discussed as the likely mechanisms for the action of these factors in causing this decline. The results emphasise the importance of understanding and assessing natural environmentally-driven change when

Richard K. F. Unsworth; Michael A. Rasheed; Kathryn M. Chartr; Anthony J. Roelofs

2012-01-01T23:59:59.000Z

185

Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies  

SciTech Connect

There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

none,

2013-06-06T23:59:59.000Z

186

Effective Personnel Exposure Control in Shortened Refueling Outages: Final Report: Review of Remote Monitoring Systems in Radiation Protection Applications  

Science Conference Proceedings (OSTI)

Remote monitoring technology (RMT) significantly enhances worker protection and reduces worker radiation exposure, particularly during shortened refueling outages. This report provides a brief description of the hardware and features of remote monitoring systems, then focuses on nuclear plant experiences in applying such systems for enhanced radiation protection. It also discusses EPRI's RMT research program and formation of the RMT Working Group to support research in this area. Such information will gr...

2003-12-02T23:59:59.000Z

187

IN-SITU PROBING OF RADIATION-INDUCED PROCESSING OF ORGANICS IN ASTROPHYSICAL ICE ANALOGS-NOVEL LASER DESORPTION LASER IONIZATION TIME-OF-FLIGHT MASS SPECTROSCOPIC STUDIES  

Science Conference Proceedings (OSTI)

Understanding the evolution of organic molecules in ice grains in the interstellar medium (ISM) under cosmic rays, stellar radiation, and local electrons and ions is critical to our understanding of the connection between ISM and solar systems. Our study is aimed at reaching this goal of looking directly into radiation-induced processing in these ice grains. We developed a two-color laser-desorption laser-ionization time-of-flight mass spectroscopic method (2C-MALDI-TOF), similar to matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectroscopy. Results presented here with polycyclic aromatic hydrocarbon (PAH) probe molecules embedded in water-ice at 5 K show for the first time that hydrogenation and oxygenation are the primary chemical reactions that occur in astrophysical ice analogs when subjected to Ly{alpha} radiation. We found that hydrogenation can occur over several unsaturated bonds and the product distribution corresponds to their stabilities. Multiple hydrogenation efficiency is found to be higher at higher temperatures (100 K) compared to 5 K-close to the interstellar ice temperatures. Hydroxylation is shown to have similar efficiencies at 5 K or 100 K, indicating that addition of O atoms or OH radicals to pre-ionized PAHs is a barrierless process. These studies-the first glimpses into interstellar ice chemistry through analog studies-show that once accreted onto ice grains PAHs lose their PAH spectroscopic signatures through radiation chemistry, which could be one of the reason for the lack of PAH detection in interstellar ice grains, particularly the outer regions of cold, dense clouds or the upper molecular layers of protoplanetary disks.

Gudipati, Murthy S.; Yang Rui, E-mail: gudipati@jpl.nasa.gov, E-mail: ryang73@ustc.edu [University of Maryland (United States)

2012-09-01T23:59:59.000Z

188

IONIZING RADIATION DOSIMETRY  

E-Print Network (OSTI)

registered certification marks of the National Institute of Standards and Technology and the federal government, who retain exclusive rights to control the use thereof. Permission to use the term and/or logo is granted to NVLAP-accredited laboratories for the limited purposes of announcing their accredited status, and for use on reports that describe only testing and calibration within the scope of accreditation. NIST reserves the right to control the quality of the use of the term NVLAP and of the NVLAP logo. Contents Contents.......................................................................................................................................................iii Foreword.......................................................................................................................................................v

Betty Ann Torres; Carlos M. Gutierrez

2005-01-01T23:59:59.000Z

189

Ionizing Radiation Detector  

Science Conference Proceedings (OSTI)

A CdZnTe (CZT) crystal provided with a native CdO dielectric coating to reduce surface leakage currents and thereby, improve the resolution of instruments incorporating detectors using CZT crystals is disclosed. A two step process is provided for forming the dielectric coating which includes etching the surface of a CZT crystal with a solution of the conventional bromine/methanol etch treatment, and passivating the CZT crystal surface with a solution of 10 w/o NH.sub.4 F and 10 w/o H.sub.2 O.sub.2 in water after attaching electrical contacts to the crystal surface.

Wright, Gomez W. (Nashville, TN); James, Ralph B. (Livermore, CA); Burger, Arnold (Nashville, TN); Chinn, Douglas A. (Livermore, CA)

2003-11-18T23:59:59.000Z

190

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

191

Radiation Physics Division  

Science Conference Proceedings (OSTI)

... The Radiation Physics Division, part of the Physical Measurement Laboratory ... the measurement standards for ionizing radiations and radioactivity ...

2013-09-05T23:59:59.000Z

192

THE BEIR-III REPORT AND THE HEALTH EFFECTS OF LOW-LEVEL RADIATION  

E-Print Network (OSTI)

Protection Against Ionizing Radiation from External Sources,Protection Against Ionizing Radiation from External Sources:induction by ionizing radiation. Brit. J. Radiol. 51: 401-

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

193

Occupational radiation exposure at commercial nuclear power reactors and other facilities 1992; Twenty-fifth annual report, Volume 14  

SciTech Connect

This report summarizes the occupational radiation exposure information that has been reported to the NRC`s Radiation Exposure Information Reporting System (REIRS) by nuclear power facilities and certain other categories of NRC licensees during the years 1969 through 1992. The bulk of the data presented in the report was obtained from annual radiation exposure reports submitted in accordance with the requirements of 10CFR20.407 and the technical specifications of nuclear power plants. Data on workers terminating their employment at certain NRC licensed facilities were obtained from reports submitted pursuant to 10CFR20.408. The 1992 annual reports submitted by about 364 licensees indicated that approximately 204,365 individuals were monitored, 183,927 of whom were monitored by nuclear power facilities. They incurred an average individual dose of 0.16 rem (cSv) and an average measurable dose of about 0.30 (cSv). Termination radiation exposure reports were analyzed to reveal that about 74,566 individuals completed their employment with one or more of the 364 covered licensees during 1992. Some 71,846 of these individuals terminated from power reactor facilities, and about 9,724 of them were considered to be transient workers who received an average dose of 0.50 rem (cSv).

Raddatz, C.T. [US Nuclear Regulatory Commission, Washington, DC (United States). Division of Regulatory Applications; Hagemeyer, D. [Science Applications International Corp., Oak Ridge, TN (United States)

1993-12-01T23:59:59.000Z

194

Out-of-Field Cell Survival Following Exposure to Intensity-Modulated Radiation Fields  

Science Conference Proceedings (OSTI)

Purpose: To determine the in-field and out-of-field cell survival of cells irradiated with either primary field or scattered radiation in the presence and absence of intercellular communication. Methods and Materials: Cell survival was determined by clonogenic assay in human prostate cancer (DU145) and primary fibroblast (AGO1552) cells following exposure to different field configurations delivered using a 6-MV photon beam produced with a Varian linear accelerator. Results: Nonuniform dose distributions were delivered using a multileaf collimator (MLC) in which half of the cell population was shielded. Clonogenic survival in the shielded region was significantly lower than that predicted from the linear quadratic model. In both cell lines, the out-of-field responses appeared to saturate at 40%-50% survival at a scattered dose of 0.70 Gy in DU-145 cells and 0.24 Gy in AGO1522 cells. There was an approximately eightfold difference in the initial slopes of the out-of-field response compared with the {alpha}-component of the uniform field response. In contrast, cells in the exposed part of the field showed increased survival. These observations were abrogated by direct physical inhibition of cellular communication and by the addition of the inducible nitric oxide synthase inhibitor aminoguanidine known to inhibit intercellular bystander effects. Additional studies showed the proportion of cells irradiated and dose delivered to the shielded and exposed regions of the field to impact on response. Conclusions: These data demonstrate out-of-field effects as important determinants of cell survival following exposure to modulated irradiation fields with cellular communication between differentially irradiated cell populations playing an important role. Validation of these observations in additional cell models may facilitate the refinement of existing radiobiological models and the observations considered important determinants of cell survival.

Butterworth, Karl T., E-mail: k.butterworth@qub.ac.u [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); McGarry, Conor K. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Trainor, Colman [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); O'Sullivan, Joe M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Clinical Oncology, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Hounsell, Alan R. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)

2011-04-01T23:59:59.000Z

195

Low Dose Radiation Research Program: DOE / NASA Joint Funded Projects  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE/NASA Joint Funded Projects DOE/NASA Joint Funded Projects NASA Source Photo Space explorers are subject to exposure to low dose ionizing radiation. Research that helps determine health risks from this exposure is funded by NASA and DOE. Source: NASA DOE's Low Dose Program and the National Aeronautics and Space Administration (NASA) jointly fund new research to develop a better scientific basis for understanding risks to humans from exposures to low doses or low fluences of ionizing radiation. Research must focus on elucidating molecular mechanisms and pathways involved in normal radiobiological responses to low dose exposure, and must have the potential to ultimately increase understanding of health outcomes from radiation exposures that are at or near current workplace exposure

196

Shellfish consumption and intertidal occupancy review, Sellafield, 2004. This note describes a review of public radiation exposure pathways due to liquid radioactive  

E-Print Network (OSTI)

a review of public radiation exposure pathways due to liquid radioactive waste discharges from the British limited to adults. The results are shown in Tables 1 to 3. Data analysis Internal exposure In addition and external exposure pathways have also been conducted by the Centre for Environment, Fisheries

197

An evaluation of theories concerning the health effects of low-dose radiation exposures  

E-Print Network (OSTI)

The danger of high, acute doses of radiation is well documented, but the effects of low-dose radiation below 100 mSv is still heavily debated. Four theories concerning the effects of lowdose radiation are presented here: ...

Wei, Elizabeth J. (Elizabeth Jay)

2012-01-01T23:59:59.000Z

198

Molecular stress response in the CNS of mice after systemic exposure to interferon-alpha, ionizing radiation and ketamine  

E-Print Network (OSTI)

Lowe et al. , 2008 MOLECULAR STRESS RESPONSE IN THE CNS OFXRLowe@lbl.gov Keywords: molecular-response, troponin T1,1 expression may be an early molecular biomarker of stress

Lowe, Xiu R.

2009-01-01T23:59:59.000Z

199

Review and Evaluation of Updated Research on the Health Effects Associated with Low-Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Potential health effects of low levels of radiation have predominantly been based on those effects observed at high levels of radiation. The authors have reviewed more than 200 percent publications in radiobiology and epidermiology related to low dose radiation and concluded that recent radiobiological studies at low-doses; that doses low dose radiation research should to holistic, systems-based approaches to develop models that define the shape of the dose-response relationships at low doses; and that these results should be combined with the latest epidermiology to produce a comprehensive understanding of radiation effects that addresses both damage, likely with a linear effect, and response, possibly with non-linear consequences.

Dauer, Lawrence T.; Brooks, Antone L.; Hoel, David G.; Morgan, William F.; Stram, Daniel; Tran, Phung

2010-07-01T23:59:59.000Z

200

Ionization detection system for aerosols  

DOE Patents (OSTI)

This invention relates to an improved smoke-detection system of the ionization-chamber type. In the preferred embodiment, the system utilizes a conventional detector head comprising a measuring ionization chamber, a reference ionization chamber, and a normally non-conductive gas triode for discharging when a threshold concentration of airborne particulates is present in the measuring chamber. The improved system utilizes a measuring ionization chamber which is modified to minimize false alarms and reductions in sensitivity resulting from changes in ambient temperature. In the preferred form of the modification, an annular radiation shield is mounted about the usual radiation source provided to effect ionization in the measuring chamber. The shield is supported by a bimetallic strip which flexes in response to changes in ambient temperature, moving the shield relative to the source so as to vary the radiative area of the source in a manner offsetting temperature-induced variations in the sensitivity of the chamber.

Jacobs, Martin E. (Chillicothe, OH)

1977-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Radiation and Biomolecular Physics Division  

Science Conference Proceedings (OSTI)

... Welcome. The Radiation and Biomolecular Physics Division is a division ... disseminate the national standards for ionizing radiations and radioactivity ...

2012-02-08T23:59:59.000Z

202

Low Dose Radiation Program: Links - Online Literature  

NLE Websites -- All DOE Office Websites (Extended Search)

Online Literature Online Literature Journals, Books and other Publications Armed Forces Radiobiology Research Institute Chornobyl Center for Nuclear Safety Radioactive Waste and Radioecology "Insight" Magazine Central Research Institute of the Electric Power Industry (CRIEPI) News: Aiming at an information center on low dose radiation research Health Physics International Journal of Radiation Biology Iranian Journal of Radiation Research Journal of Radiological Protection National Council on Radiation Protection and Measurements Radiation Research U.S. Department of Energy (DOE) Information Bridge Reports Animal Cancer Tests and Human Cancer Risk Assessment: A Broad Perspective Effects of Ionizing Radiation: Atomic Bomb Survivors and Their Children (1945-1995) Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR

203

DOE Radiation Exposure Monitoring System (REMS) Data Update Presented at the 32nd Annual International Dosimetry and Records Symposium, June 3-6, Scottsdale, AZ  

Science Conference Proceedings (OSTI)

This slide-show presents the 2012 draft data for DOE occupational radiation exposure, compares those data with last year and the last five years, and clarifies reporting data.

none,

2013-01-01T23:59:59.000Z

204

Welding arc gap ionization device  

SciTech Connect

An alpha emitting isotope is positioned near the tip of a TIG welding electrode so that the alpha radiation can provide an ionized path between the electrode and the workpiece.

Schweikhardt, George M. (Richland, WA)

1976-01-01T23:59:59.000Z

205

Risk of Low Dose/Low Dose Rate Ionizing Radiation to Humans Symposium at the EMS 2009 Annual Meeting - September 2006  

Science Conference Proceedings (OSTI)

The low dose symposium thoughtfully addressed controversy of risk from low dose radiation exposure, hormesis and radon therapy. The stem cell symposium cogently considered the role of DNA damage and repair in hematopoietic stem cells underlying aging and malignancy and provocatively presented evidence that stem cells may have distinct morphologies and replicative properties, as well as special roles in cancer initiation. In the epigenetics symposium, studies illustrated the long range interaction of epigenetic mechanisms, the roles of CTCF and BORIS in region/specific regulation of epigenetic processes, the impact of DNA damage on epigenetic processes as well as links between epigenetic mechanisms and early nutrition and bystander effects.

Morgan, William F.; von Borstel, Robert C.; Brenner,; Redpath, J. Leslie; Erickson, Barbra E.; Brooks,

2009-11-12T23:59:59.000Z

206

Nuclear Instruments and Methods in Physics Research A 564 (2006) 319323 Passive monitoring of the equilibrium factor inside a radon exposure  

E-Print Network (OSTI)

-lived radon progeny contributes about half of the total exposure of human beings to ionizing radiationNuclear Instruments and Methods in Physics Research A 564 (2006) 319­323 Passive monitoring for passive monitoring of the equilibrium factor F inside a radon exposure chamber. The method is based

Yu, K.N.

207

Analysis of radiation exposure for additional naval personnel at Operation CASTLE - supplemental report. Technical report, 24 Apr-20 Nov 89  

SciTech Connect

This report supplements DNA-TR-84-6 by analyzing the radiation exposure for typical crewmembers of eight additional ships at Operation CASTLE in 1954: RECLAIMER, SHEA, COCOPA, MENDER, MOLALA, TAWAKONI, PC-1546, and LST-1146. Utilizing the reconstructed radiation environments from deck contamination, water shine, proximate ship shine, and contaminated hulls and piping, equivalent film badge doses are calculated and compared with analyzed film badge dosimetry. Comparisons are hampered by a shortage of badge readings and by cohort badging that may have emphasized non-representative crew activities. Considering this, agreement is good (within a few hundred millirem) when doses were high but less when doses were low. In all cases, overall totals appear to be in excellent agreement.

Thomas, C.; Geotz, J.; Klemm, J.; Ortlieb, E.

1991-10-01T23:59:59.000Z

208

Estimation of Internal Radiation Dose from both Immediate Releases and Continued Exposures to Contaminated Materials  

Science Conference Proceedings (OSTI)

A brief description is provided of the basic concepts related to 'internal dose' and how it differs from doses that result from radioactive materials and direct radiation outside of the body. The principles of radiation dose reconstruction, as applied to both internal and external doses, is discussed based upon a recent publication prepared by the US National Council on Radiation Protection and Measurements. Finally, ideas are introduced related to residual radioactive contamination in the environment that has resulted from the releases from the damaged reactors and also to the management of wastes that may be generated in both regional cleanup and NPP decommissioning.

Napier, Bruce A.

2012-03-26T23:59:59.000Z

209

The risk equivalent of an exposure to-, versus a dose of radiation  

SciTech Connect

The long-term potential carcinogenic effects of low-level exposure (LLE) are addressed. The principal point discussed is linear, no-threshold dose-response curve. That the linear no-threshold, or proportional relationship is widely used is seen in the way in which the values for cancer risk coefficients are expressed - in terms of new cases, per million persons exposed, per year, per unit exposure or dose. This implies that the underlying relationship is proportional, i.e., ''linear, without threshold''. 12 refs., 9 figs., 1 tab.

Bond, V.P.

1986-01-01T23:59:59.000Z

210

A Personal Experience Reducing Radiation Exposures: Protecting Family in Kiev during the First Two Weeks after Chernobyl  

SciTech Connect

The Chernobyl nuclear reactor accident occurred in 1986. The plume from the explosions and fires was highly radioactive and resulted in very high exposure levels in the surrounding regions. This paper describes how the people in Kiev, Ukraine, a city 90 miles (120 km) south of Chernobyl, and in particular one individual in that city, Professor Vitaly Eremenko, became aware of the threat before the official announcement and the steps he took to mitigate potential impacts to his immediate family. The combination of being informed and using available resources led to greatly reduced consequences for his family and, in particular, his newborn granddaughter. He notes how quickly word of some aspects of the hazard spread in the city and how other aspects appear to not have been understood. Although these events are being recalled as the 20th anniversary of the terrible event approaches, the lessons are still pertinent today. Threats of possible terrorist use of radiation dispersal devices makes knowledge of effective individual actions for self-protection from radiation exposures a topic of current interest.

Eremenko, Vitaly A.; Droppo, James G.

2006-08-01T23:59:59.000Z

211

Thyroid cancer in the Marshallese: relative risk of short-lived internal emitters and external radiation exposure  

Science Conference Proceedings (OSTI)

In a study of the comparative effects of internal versus external irradiation of the thyroid in young people, we determined that the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times less thyroid cancer than did the same dose of radiation given externally. We determined this finding for a group of 85 Marshall Islands children, who were less than 10 years of age at the time of exposure and who were accidentially exposed to internal and external thyroid radiation at an average level of 1400 rad. The external risk coefficient ranged between 2.5 and 4.9 cancers per million person-rad-years at risk, and thus, from our computations, the internal risk coefficient for the Marshallese children was estimated to range between 1.0 and 1.4 cancers per million person-rad-years at risk. In contrast, for individual more than 10 years of age at the time of exposure, the dose from internal irradiation of the thyroid with short-lived internal emitters produced several times more thyroid cancer than did the same dose of radiation given externally. The external risk coefficients for the older age groups were reported in the literature to be in the range of 1.0 to 3.3 cancers per million person-rad-years-at risk. We computed internal risk coefficients of 3.3 to 8.1 cancers per million person-rad-years at risk for adolescent and adult groups. This higher sensitivity to cancer induction in the exposed adolescents and adults, is different from that seen in other exposed groups. 14 refs., 8 tabs.

Lessard, E.T.; Brill, A.B.; Adams, W.H.

1985-01-01T23:59:59.000Z

212

Low Dose Radiation Research Program: Genetic Factors Affecting  

NLE Websites -- All DOE Office Websites (Extended Search)

Affecting Susceptibility to Low-Dose Radiation Affecting Susceptibility to Low-Dose Radiation William F. Morgan Pacific Northwest National Laboratory Why This Project The short-term effects of high doses of ionizing radiation on cellular responses are relatively well understood. Less clear are the long-term consequences of exposure to low dose/low dose-rate radiation and the effects of radiation exposure on the progeny of surviving cells. If a cell survives radiation, it is generally thought to have repaired all the radiation-induced insults and be capable of a "normal healthy life". At a certain frequency, however, we have found that some cells surviving radiation grow normally, but will rearrange their genetic material during time in culture. We call this radiation-induced genomic instability. Many

213

How to Detect Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

How to Detect Radiation How to Survey Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Detection How...

214

REGULATORY GUIDE 8.18 liNJFORMATIOiN RELEVANT TO EiNSURING THAT OCCUPATIONAL RADIATION EXPOSURES AT MEL)ICAL INSTITUTIONS,rILL BE AS LOW AS,IEASONAdLY ACHIEVABLE  

E-Print Network (OSTI)

Paragraph 20.1(c) of 10 CFR Part 20, "Standards for Protection Against Radiation, " states that licensees should make every reasonable effort to keep radiation exposures, as well as releases of radioactive material to unrestricted

unknown authors

1982-01-01T23:59:59.000Z

215

RADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. RADIATION EXPOSURE CONTROL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2.2. Internal ExposureRADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND RADIATION SAFETY MANUAL UNIVERSITY OF MARYLAND

Rubloff, Gary W.

216

Method and apparatus for reducing radiation exposure through the use of infrared data transmission  

SciTech Connect

A method and apparatus is described for transmitting information, for exae, dosimetry data from a hazardous environment such as a radioactive area to a remote relatively safe location. A radiation detector senses the radiation and generates an electrical signal which is fed as a binary coded decimal signal to an infrared transmitter having a microprocessor. The microprocessor formats the detected information into digits of data and modulates a 40 kHz oscillator, the output of which is fed to and intensity modulates one or more infrared emitting diodes. The infrared signal from the diodes is transmitted to a portable hand-held infrared receiver remote from the hazardous environment. The receiver includes an infrared sensitive diode which decodes the data and generates an electrical signal which is coupled to a microcomputer. The microcomputer synchronizes itself to the transmitter, reads the digits of data as they are received, sums the digits and compares the sum with a checksum signal generated and transmitted from the transmitter. If a match of the checksum signals exists, the received data is displayed, otherwise it is described and the receiver conditions itself for the next transmission of data.

Austin, Frank S. (Schaghticoke, NY); Hance, Albert B. (Schenectady, NY)

1989-01-01T23:59:59.000Z

217

SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell migration of primary endothelial cells upon low LET radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell SHP-2 tyrosine phosphate-dependent focal adhesion kinase mediated cell migration of primary endothelial cells upon low LET radiation exposure Xiangpeng Zheng, 1 Sumathy Mohan, 3 and Mohan Natarajan 1,2 Departments of 1 Otolaryngology, 2 Radiation Oncology, and 3 Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 The influence and mechanism of low LET radiation exposure on wound healing process is not yet fully understood. Based on the vital role of endothelial cells in migration and wound healing, this study investigated the response of endothelial cells to low-dose irradiation and the underlying mechanism. A wound was inflicted in the confluent monolayer of primary vascular endothelial cells exposing a cell-free zone on the plate. The cells were then exposed

218

Occupational radiation exposure at commercial nuclear power reactors and other facilities 1996: Twenty-ninth annual report. Volume 18  

SciTech Connect

This report summarizes the occupational exposure data that are maintained in the US Nuclear Regulatory Commission`s (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 1996 annual reports submitted by six of the seven categories of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. Since there are no geologic repositories for high level waste currently licensed, only six categories will be considered in this report. Annual reports for 1996 were received from a total of 300 NRC licensees, of which 109 were operators of nuclear power reactors in commercial operation. Compilations of the reports submitted by the 300 licensees indicated that 138,310 individuals were monitored, 75,139 of whom received a measurable dose. The collective dose incurred by these individuals was 21,755 person-cSv (person-rem){sup 2} which represents a 13% decrease from the 1995 value. The number of workers receiving a measurable dose also decreased, resulting in the average measurable dose of 0.29 cSv (rem) for 1996. The average measurable dose is defined to be the total collective dose (TEDE) divided by the number of workers receiving a measurable dose. These figures have been adjusted to account for transient reactor workers. Analyses of transient worker data indicate that 22,348 individuals completed work assignments at two or more licensees during the monitoring year. The dose distributions are adjusted each year to account for the duplicate reporting of transient workers by multiple licensees. In 1996, the average measurable dose calculated from reported was 0.24 cSv (rem). The corrected dose distribution resulted in an average measurable dose of 0.29 cSv (rem).

Thomas, M.L. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Hagemeyer, D. [Science Applications International Corp., Oak Ridge, TN (United States)

1998-02-01T23:59:59.000Z

219

Estimates of Radiation Exposures for Human Crews in Deep Space from the January 15, 2005, Solar Energetic Particle Event Using the Earth-Moon-Mars Radiation Environment Module  

Science Conference Proceedings (OSTI)

Technical Paper / Special Issue on the 16th Biennial Topical Meeting of the Radiation Protection and Shielding Division / Radiation Transport and Protection

Mahmoud PourArsalan; Lawrence W. Townsend; Nathan A. Schwadron; Kamen Kozarev; Maher A. Dayeh; Mihir I. Desai

220

THE RADIATION CHEMISTRY OP AMINO ACIDS, PEPTIDES AND PROTEINS IN RELATION TO THE RADIATION STERILIZATION OF HIGH-PROTEIN FOODS  

E-Print Network (OSTI)

to Various Ionizing Radiations. Radiat. Res. , 22, 694 (1968). W. M. Garrison, Radiation Induced Reactions of AminoFrozen Aqueous Solutions, in Radiation Chemistry of Aqueous

Garrison, W.M.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Nevada Test Site Radiation Protection Program - Revision 1  

SciTech Connect

Title 10 Code of Federal Regulations (CFR) Part 835, 'Occupational Radiation Protection,' establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (on-site or off-site) U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration off-site projects. This NTS RPP promulgates the radiation protection standards, limits, and program requirements for occupational exposure to ionizing radiation resulting from NNSA/NSO activities at the NTS and other operational areas as stated in 10 CFR 835.1(a). NNSA/NSO activities (including design, construction, operation, and decommissioning) within the scope of this RPP may result in occupational exposures to radiation or radioactive material. Therefore, a system of control is implemented through specific references to the site-specific NV/YMP RCM. This system of control is intended to ensure that the following criteria are met: (1) occupational exposures are maintained as low as reasonably achievable (ALARA), (2) DOE's limiting values are not exceeded, (3) employees are aware of and are prepared to cope with emergency conditions, and (4) employees are not inadvertently exposed to radiation or radioactive material.

Radiological Control Managers' Council

2008-06-01T23:59:59.000Z

222

Inference of Causal Networks from Time-course Transcription Data in Response to a2 Gy Challenge Dose of Ionizing Radiation with or without a 10 cGy Priming Dose  

NLE Websites -- All DOE Office Websites (Extended Search)

Causal Networks from Time-course Transcription Data in Response to a Causal Networks from Time-course Transcription Data in Response to a 2 Gy Challenge Dose of Ionizing Radiation with or without a 10 cGy Priming Dose Kai Zhang, Ju Han, Torsten Groesser, Priscilla Cooper, and Bahram Parvin Lawrence Berkeley National Laboratory Goal: To elucidate temporal-dependent gene templates, causal networks, and underlying biological processes that can be inferred in response to a 10 cGy priming dose with or without a later higher challenged dose. Background and significance: Mechanistic inference of regulatory network can provide new insights into radiation systems biology. The main challenge continues to be high dimensionality of data, complex network architecture and limited knowledge of biological processes.

223

Molecular Dynamics Model of Ultraviolet Matrix-Assisted Laser Desorption/Ionization Including Ionization Processes  

E-Print Network (OSTI)

Molecular Dynamics Model of Ultraviolet Matrix-Assisted Laser Desorption/Ionization Including A molecular dynamics model of UV-MALDI including ionization processes is presented. In addition/desorption of molecular systems, it includes radiative and nonradiative decay, exciton hopping, two pooling processes

Zhigilei, Leonid V.

224

Results of calculations of external gamma radiation exposure rates from local fallout and the related radionuclide compositions of selected US Pacific events  

SciTech Connect

This report presents data on calculated gamma radiation exposure rates and local surface deposition of related radionuclides resulting from selected US Pacific events. Results of the calculations of relative external gamma radiation exposure rate and related radionuclide ground deposition are given in six appendices. The output of the calculation has 30 decay times: 10 from 1 to 21 h, 10 from 1 to 300 d, and 10 from 1 to 50 y. For each of these times and for zero time, there are values of the external gamma radiation exposure rate normalized to 1 mR/h, 1 m above the surface, 12 h after the event; the associated values of ..mu..Ci/m/sup 2/ for each radionuclide; and the total ..mu..Ci/m/sup 2/. Surface roughness effects are simulated by using Beck's values of (mR/h)/..mu..Ci/m/sup 2/) for a relaxation length of 0.16 g/cm/sup 2/. Fractionation effects, simulated by the removal of a fraction of the refractory nuclides from the calculation, were found for unfractionated debris and for debris with 0.5 and 0.1 of the refractory elements present. Each Appendix contains three sets of 11 pages of calculated results relating to one event in Table 1. Each set of 11 pages is marked page 2 through page 12. Page 2 of each set gives the external gamma-ray exposure rates and associated values of total microcuries per square meter at 30 decay intervals and at zero time. The value for each activation product at zero time is the result of a measurement. The measurements were performed on debris samples taken by aircraft approximately 1 to 4 h after detonation. When no measurement exists, the value appears as zero. Fission products were calculated from the fissioning nuclides and neutron energy spectra. Calculated values for each radionuclide at various decay intervals are given.

Hicks, H.G.

1984-02-01T23:59:59.000Z

225

Chapter 16: Log-linear regression for Poisson counts Exposure to ionizing radiation is recognized as a cancer risk. In the United States, EPA  

E-Print Network (OSTI)

the past few decades. These estimates have been based largely on data for survivors of the atomic bombings of the Nagasaki and Hiroshima atomic bombs. -3-2-10 0-7 12-1 20-2 28-3 0-7 12-1 20-2 28-3 0-7 12-1 20-2 28-3 -3 to the incidence of cancer. The data dis- cussed below report the number of cancer deaths among the survivors

Bardsley, John

226

The association betweeen cancers and low level radiation: An evaluation of the epidemiological evidence at the Hanford Nuclear Weapons Facility  

Science Conference Proceedings (OSTI)

Cancer has traditionally been linked to exposure to high doses of radiation, but there is considerable controversy regarding the carcinogenicity of low doses of ionizing radiation in humans. Over the past 30 years there have been 14 studies conducted on employees at the Hanford nuclear weapons facility to investigate the relationship between exposure to low doses of radiation and mortality due to cancer (1-14). Interest in this issue was originally stimulated by the Atomic Energy Commission (AEC) which was trying to determine whether the linear extrapolation of health effects from high to low dose exposure was accurate. If the risk has been underestimated, then the maximum permissible occupational radiation exposure in the United States had been set too high. Because the health risk associated with low level radiation are unclear and controversial it seems appropriate to review the studies relating to Hanford at this time.

Britton, J. [Univ. of California, Berkeley, CA (United States). School of Public Health]|[Lawrence Berkeley National Lab., CA (United States)

1993-05-01T23:59:59.000Z

227

Low Dose Radiation Research Program: Current Funded Project Descriptions  

NLE Websites -- All DOE Office Websites (Extended Search)

Funded Project Descriptions Funded Project Descriptions Effects Of Low Doses of Radiation on DNA Repair Jointly funded by NASA and DOE Eric J Ackerman Pacific Northwest National Laboratory Richland, WA 99352 Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

228

Low Dose Radiation Research Program: Project Descriptions-Archive  

NLE Websites -- All DOE Office Websites (Extended Search)

Project Descriptions-Archive Project Descriptions-Archive Effects Of Low Doses of Radiation on DNA Repair Eric J Ackerman (former PNNL) (Jointly funded by NASA and DOE) Pacific Northwest National Laboratory Richland, WA Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

229

RESRAD-RECYCLE : a computer model for analyzing radiation exposures resulting from recycling radioactively contaminated scrap metals or reusing ratioactively surface-contaminated materials and equipment.  

Science Conference Proceedings (OSTI)

RESRAD-RECYCLE is a computer code designed by Argonne National Laboratory (ANL) to be used in making decisions about the disposition of radioactively contaminated materials and scrap metals. It implements a pathway analysis methodology to evaluate potential radiation exposures resulting from the recycling of contaminated scrap metals and the reuse of surface-contaminated materials and equipment. For modeling purposes, it divides the entire metal recycling process into six steps: (1) scrap delivery, (2) scrap melting, (3) ingot delivery, (4) product fabrication, (5) product distribution, and (6) use of finished product. RESRAD-RECYCLE considers the reuse of surface-contaminated materials in their original forms. It contains representative exposure scenarios for each recycling step and the reuse process; users can also specify scenarios if desired. The model calculates individual and collective population doses for workers involved in the recycling process and for the public using the finished products. The results are then used to derive clearance levels for the contaminated materials on the basis of input dose restrictions. The model accounts for radiological decay and ingrowth, dilution and partitioning during melting, and distribution of refined metal in the various finished products, as well as the varying densities and geometries of the radiation sources during the recycling process. A complete material balance in terms of mass and radioactivity during the recycling process can also be implemented. In an international validation study, the radiation doses calculated by RESRAD-RECYCLE were shown to agree fairly well with actual measurement data.

Cheng, J. J.; Kassas, B.; Yu, C.; Arnish, J. J.; LePoire, D.; Chen, S.-Y.; Williams, W. A.; Wallo, A.; Peterson, H.; Environmental Assessment; DOE; Univ. of Texas

2004-11-01T23:59:59.000Z

230

THE EFFECTS OF IONIZING RADIATIONS ON PERIPHERAL NERVE. PART I. THE EFFECTS OF IN SITU X-IRRADIATION ON MAMMALIAN NERVE ACTION POTENTIAL. PART II. ALTERATION OF RESTING, ACTION AND LOCAL POTENTIALS OF CRAYFISH GIANT AXONS BY UV IRRADIATION. Progress Report, 1959-1960  

SciTech Connect

Progress is reported in studies on the sensitivity of nerves to exposure to x and ultraviolet radiation. Findings are reported on the response of the sciatic nerve of cats exposed in situ to x radiation and on the response of crayfish giant axons exposed to ultraviolet radiation. Data are presented graphically and results are discussed. (C.H.)

Duvall, C.P.; Gasteiger, E.L.; Daube, J.R.

1960-10-31T23:59:59.000Z

231

Low Dose Radiation Research Program: Computational Modeling of Biochemical  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Modeling of Biochemical Pathways Linking Ionizing Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest, Apoptosis, and Tumor Incidence Authors: Yuchao Maggie Zhao and Rory Conolly Institutions: Center for Computational Systems Biology CIIT Centers for Health Research Long-Range Goal: To develop an integrated, computational framework for the prediction of low-dose-response to ionizing radiation (IR) in people. Methodology: To provide a flexible framework to evaluate mechanisms of cellular adaptive responses after exposure to IR, three progressively more complicated descriptions of biochemical pathways linking DNA damage with cell-cycle checkpoint control and apoptosis were developed. These descriptions focus on p53-dependent checkpoint arrest and apoptosis, p73-dependent apoptosis, and Chk2-dependent checkpoint arrest,

232

Unexpected photoreactivation of Vibrio harveyi bacteria living in ionization environment  

SciTech Connect

Bacteria undergoing environmental effects is extremely interesting for structural, mechanistic, and evolutionary implications. Luminescent bacteria that have evolved in a specific ambient have developed particular responses and their behavior can give us new suggestions on the task and production of luciferina proteins. To analyze the UV interaction under controlled laboratory conditions, we used photoluminescent bacterial strains belonging to a new species evolutionarily close to Vibrio harveyi sampled from a coastal cave with a high radon content that generates ionizing radiation. The survival of the bacterial strains was analyzed, in the light and in the dark, following a variety of genotoxic treatments including UV radiation exposure. The strains were irradiated by a germicide lamp. The results demonstrated that most of the strains exhibited a low rate of survival after the UV exposure. After irradiation by visible light following the UV exposure, all strains showed a high capability of photoreactivation when grown. This capability was quite unexpected because these bacteria were sampled from a dark ambient without UV radiation. This leads us to hypothesize that the photoreactivation in these bacteria might have been evolved to repair DNA lesions also induced by different radiation sources other than UV (e.g., x-ray) and that the luminescent bacteria might use their own light emission to carry out the photoreactivation. The high capability of photoreactivation of these bacteria was also justified by the results of deconvolution. The deconvolution was applied to the emission spectra and it was able to show evidence of different light peaks. The presence of the visible peak could control the photolysis enzyme.

Alifano, P.; Tala, A.; Tredici, S. M. [Dipartimento Microbiologia, Di.S.Te.B.A., Universita del Salento, via Provinciale Lecce-Monteroni, C.P. 193, 73100 Lecce (Italy); Nassisi, V. [Laboratorio di Elettronica Applicata e Strumentazione, LEAS, Dipartimento di Fisica, Universita del Salento and INFN-Lecce, Via Provinciale Lecce-Monteroni, 73100 Lecce (Italy); Siciliano, M. V. [Laboratorio di Elettronica Applicata e Strumentazione, LEAS, Dipartimento di Fisica, Universita del Salento and INFN-Lecce, Via Provinciale Lecce-Monteroni, 73100 Lecce (Italy); Dipartimento di Scienza dei Materiali, University of Salento, via Provinciale Lecce- Monteroni, C.P. 193, 73100 Lecce (Italy)

2011-05-15T23:59:59.000Z

233

BEIR-III report and the health effects of low-level radiation  

SciTech Connect

The present BEIR-III Committee has not highlighted any controversy over the health effects of low-level radiation. In its evaluation of the experimental data and epidemiological surveys, the Committee has carefully reviewed and assessed the value of all the available scientific evidence for estimating numerical risk coefficients for the health hazards to human populations exposed to low levels of ionizing radiation. Responsible public awareness of the possible health effects of ionizing radiations from medical and industrial radiation exposure, centers on three important matters of societal concern: (1) to place into perspective the extent of harm to the health of man and his descendants to be expected in the present and in the future from those societal activities involving ionizing radiation; (2) to develop quantitative indices of harm based on dose-effect relationships; such indices could then be used with prudent caution to introduce concepts of the regulation of population doses on the basis of somatic and genetic risks; and (3) to identify the magnitude and extent of radiation activities which could cause harm, to assess their relative significance, and to provide a framework for recommendations on how to reduce unnecessary radiation exposure to human populations. The main difference of the BEIR Committee Report is not so much from new data or new interpretations of existing data, but rather from a philosophical approach and appraisal of existing and future radiation protection resulting from an atmosphere of constantly changing societal conditions and public attitudes. (PCS)

Fabrikant, J.I.

1980-01-01T23:59:59.000Z

234

Technology, safety, and costs of decommissioning reference nuclear research and test reactors: sensitivity of decommissioning radiation exposure and costs to selected parameters  

Science Conference Proceedings (OSTI)

Additional analyses of decommissioning at the reference research and test (R and T) reactors and analyses of five recent reactor decommissionings are made that examine some parameters not covered in the initial study report (NUREG/CR-1756). The parameters examined for decommissioning are: (1) the effect on costs and radiation exposure of plant size and/or type; (2) the effects on costs of increasing disposal charges and of unavailability of waste disposal capacity at licensed waste disposal facilities; and (3) the costs of and the available alternatives for the disposal of nuclear R and T reactor fuel assemblies.

Konzek, G.J.

1983-07-01T23:59:59.000Z

235

10 CFR 835- Occupational Radiation Protection  

Energy.gov (U.S. Department of Energy (DOE))

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

236

Code of Federal Regulations OCCUPATIONAL RADIATION PROTECTION  

Energy.gov (U.S. Department of Energy (DOE))

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

237

Radiation Chemistry and Photochemistry of Ionic Liquids  

NLE Websites -- All DOE Office Websites (Extended Search)

the nuclear fuel cycle. Therefore, an understanding of the interactions of ionizing radiation and photons with ionic liquids is strongly needed. However, the radiation chemistry...

238

Acute radiation syndrones and their management  

Science Conference Proceedings (OSTI)

Radiation syndromes produced by large doses of ionizing radiation are divided into three general groups depending on dose of radiation and time after exposure. The CNS syndrome requires many thousands of rad, appears in minutes to hours, and kills within hours to days. The GIS appears after doses of a few hundred to 2000 rad. It is characterized by nausea, vomiting, diarrhea, and disturbances of water and electrolyte metabolism. It has a high mortality in the first week after exposure. Survivors will then experience the HS as a result of marrow aplasia. Depending on dose, survival is possible with antibiotic and transfusion therapy. The relationship of granulocyte depression to mortality in dogs and human beings is illustrated. The role of depth dose pattern of mortality of radiation exposure is described and used as an indication of why air exposure doses may be misleading. The therapy of radiation injury is described based on antibiotics, transfusion therapy, and use of molecular regulators. The limited role of matched allogenic bone marrow transplants is discussed. 52 refs., 13 figs.

Cronkite, E.P.

1988-01-01T23:59:59.000Z

239

Space charge dosimeters for extremely low power measurements of radiation in shipping containers  

DOE Patents (OSTI)

Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes insitu polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

Britton, Jr., Charles L. (Alcoa, TN); Buckner, Mark A. (Oak Ridge, TN); Hanson, Gregory R. (Clinton, TN); Bryan, William L. (Knoxville, TN)

2011-05-03T23:59:59.000Z

240

Space charge dosimeters for extremely low power measurements of radiation in shipping containers  

DOE Patents (OSTI)

Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes in situ polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

Britton, Jr.; Charles L. (Alcoa, TN); Buckner, Mark A. (Oak Ridge, TN); Hanson, Gregory R. (Clinton, TN); Bryan, William L. (Knoxville, TN)

2011-04-26T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Alpha Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Basics of Radiation Basics of Radiation Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Basics of Radiation Characteristics of Alpha Radiation 1. Alpha radiation is not able to penetrate skin. 2. Alpha-emitting materials can be harmful to humans if the materials are inhaled, swallowed, or absorbed through open wounds. 3. A variety of instruments have been designed to measure alpha radiation. Special training in use of these instruments is essential for making accurate measurements. 4. A civil defense instrument (CD V-700) cannot detect the presence of radioactive materials that produce alpha radiation unless the radioactive materials also produce beta and/or gamma radiation.

242

Remote radiation dosimetry  

DOE Patents (OSTI)

Disclosed are methods and apparatus for remotely measuring radiation levels. Such are particularly useful for measuring relatively high levels or dosages of radiation being administered in radiation therapy. They are also useful for more general radiation level measurements where remote sensing from the remaining portions of the apparatus is desirable. The apparatus uses a beam generator, such as a laser beam, to provide a stimulating beam. The stimulating beam is preferably of wavelengths shorter than 6 microns, or more advantageously less than 2 microns. The stimulating beam is used to stimulate a remote luminescent sensor mounted in a probe which emits stored luminescent energy resulting from exposure of the sensor to ionizing radiation. The stimulating beam is communicated to the remote luminescent sensor via transmissive fiber which also preferably serves to return the emission from the luminescent sensor. The stimulating beam is advantageously split by a beam splitter to create a detector beam which is measured for power during a reading period during which the luminescent phosphor is read. The detected power is preferably used to control the beam generator to thus produce desired beam power during the reading period. The luminescent emission from the remote sensor is communicated to a suitable emission detector, preferably after filtering or other selective treatment to better isolate the luminescent emission.

Braunlich, Peter F. (Pullman, WA); Tetzlaff, Wolfgang (Pullman, WA); Hegland, Joel E. (Pullman, WA); Jones, Scott C. (Pullman, WA)

1991-01-01T23:59:59.000Z

243

Remote radiation dosimetry  

DOE Patents (OSTI)

Disclosed are methods and apparatus for remotely measuring radiation levels. Such are particularly useful for measuring relatively high levels or dosages of radiation being administered in radiation therapy. They are also useful for more general radiation level measurements where remote sensing from the remaining portions of the apparatus is desirable. The apparatus uses a beam generator, such as a laser beam, to provide a stimulating beam. The stimulating beam is preferably of wavelengths shorter than 6 microns, or more advantageously less than 2 microns. The stimulating beam is used to stimulate a remote luminescent sensor mounted in a probe which emits stored luminescent energy resulting from exposure of the sensor to ionizing radiation. The stimulating beam is communicated to the remote luminescent sensor via a transmissive fiber which also preferably serves to return the emission from the luminescent sensor. The stimulating beam is advantageously split by a beam splitter to create a detector beam which is measured for power during a reading period during which the luminescent phosphor is read. The detected power is preferably used to control the beam generator to thus produce desired beam power during the reading period. The luminescent emission from the remote sensor is communicated to a suitable emission detector, preferably after filtering or other selective treatment to better isolate the luminescent emission. 8 figures.

Braunlich, P.F.; Tetzlaff, W.; Hegland, J.E.; Jones, S.C.

1991-03-12T23:59:59.000Z

244

Radiators  

SciTech Connect

A heat-exchange radiator is connected to a fluid flow circuit by a connector which provides one member of an interengageable spigot and socket pair for push-fit, fluid-tight, engagement between the connector and the radiator, with latching formations at least one of which is resilient. Preferably the connector carries the spigot which tapers and engages with a socket of corresponding shape, the spigot carrying an O-ring seal and either latching fingers or a resilient latching circlip.

Webster, D. M.

1985-07-30T23:59:59.000Z

245

Low Dose Radiation Research Program: Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Characterization of the Roles of SOD Genes in Mammalian Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li, Zhanjun Guo, Zhonghui Yang, and Eric Chuang Institutions: Dept of Radiation Oncology, Duke University Medical Center, Durham, NC Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Background The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

246

Hydrogen peroxide significantly contributes to radiation-induced genomic instability  

NLE Websites -- All DOE Office Websites (Extended Search)

peroxide significantly contributes to radiation- peroxide significantly contributes to radiation- induced genomic instability Disha Dayal 1 , Sean M. Martin 1 , Sujatha Venkataraman 1 , Charles L. Limoli 2 , Douglas R Spitz 1 . 1 Free Radical and Radiation Biology Program, The University of Iowa, Iowa City, IA- 52246, 2 Department of Radiation Oncology, The University of California, Irvine, CA-92697 Chronic metabolic oxidative stress is associated with genomic instability following exposure to ionizing radiation (IR). Mitochondria have long been known to be a major source of reactive oxygen species (ROS) capable of causing oxidative stress. We hypothesized that radiation damages mitochondria, leading to oxidative stress and eventually genomic instability. This hypothesis is based on preliminary studies in parental

247

Low Dose Radiation Research Program: 2003 Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Characterization of the Roles of SOD Genes in Mammalian Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li,1 Eric Chuang2 Institutions: 1Dept of Radiation Oncology, Duke University Medical Center, Durham, NC, 2Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore, internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

248

Multiscale non-adiabatic dynamics with radiative decay, case study on the post-ionization fragmentation of rare-gas tetramers  

E-Print Network (OSTI)

In this supplementary material, we recollect, for reader's convenience, the general scheme of suggested multiscale model (Sec. 1), and basic informations about approaches used for pilot study: a detailed description of the interaction model (Sec. 2) and dynamical methods used for the dark dynamics step (Sec. 3) reported previously in two preceding studies [1, 2]. In addition, a detailed description of the treatment of radiative processes is also given (Sec. 4).

Jane?ek, Ivan; Naar, Pavel; Renard, Frederic; Kalus, René; Gadéa, Florent X

2012-01-01T23:59:59.000Z

249

Electron Emission From Slightly Oxidized Delta-stabilized Plutonium Generated by its Radioactivity, and Radiation Induced Ionization and Dissociation of Hydrogen at its Surface  

DOE Green Energy (OSTI)

Energy dependent electron emission between zero and 1.4 keV generated by the natural reactivity of plutonium was measured by an electrostatic spectrometer with known acceptance angle and acceptance area. The electron spectral intensity decreases continuously except for a distinctive feature of unknown origin at approximately 180eV. The spectrum was converted to energy dependent electron flux (e/cm{sup 2} s) using the assumption that the emission has a cosine angular distribution. The energy dependent electron mean free path in gases and literature cross sections for electron induced reactions were used to determine the number of ionization and dissociation reactions per cm{sup 2} second, found to be about 8*10{sup 8}/cm{sup 2}s and 1.5*10{sup 8}/cm{sup 2}s, respectively, for hydrogen. These results are to be used with caution until complementary measurements can be made, e.g. independent measurement of the total emitted electron current, since the results here are based on the assumption that the electron emission has a cosine angular distribution. That is unlikely to be correct.

Siekhaus, W J; Nelson, A J

2011-10-26T23:59:59.000Z

250

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation  

Science Conference Proceedings (OSTI)

Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinomas and non-Hodgkin's B-cell lymphomas. Nonstructural protein 3 (NS3) of HCV possesses serine protease, nucleoside triphosphatase, and helicase activities, while NS4A functions as a cofactor for the NS3 serine protease. Here, we show that HCV NS3/4A interacts with the ATM (ataxia-telangiectasia mutated), a cellular protein essential for cellular response to irradiation. The expression of NS3/4A caused cytoplasmic translocation of either endogenous or exogenous ATM and delayed dephosphorylation of the phosphorylated ATM and {gamma}-H2AX following ionizing irradiation. As a result, the irradiation-induced {gamma}-H2AX foci persisted longer in the NS3/4A-expressing cells. Furthermore, these cells showed increased comet tail moment in single-cell electrophoresis assay, indicating increased double-strand DNA breaks. The cells harboring an HCV replicon also exhibited cytoplasmic localization of ATM and increased sensitivity to irradiation. These results demonstrate that NS3/4A impairs the efficiency of DNA repair by interacting with ATM and renders the cells more sensitive to DNA damage. This effect may contribute to HCV oncogenesis.

Lai, Chao-Kuen; Jeng, King-Song [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Machida, Keigo [Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States); Cheng, Yi-Sheng [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Lai, Michael M.C. [Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan (China); Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2001 Zonal Avenue, Los Angeles, CA 90033 (United States)], E-mail: michlai@gate.sinica.edu.tw

2008-01-20T23:59:59.000Z

251

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

E-Print Network (OSTI)

R.B. Mikkelsen, Ionizing radiation-induced, mitochondria-W.K. Rorrer, P.B. Chen, Radiation-induced proliferation ofresponse genes to ionizing radiation in human lymphoblastoid

Wyrobek, A. J.

2011-01-01T23:59:59.000Z

252

Historical Exposures to Chemicals at the Rocky Flats Nuclear Weapons Plant: A Pilot Retrospective Exposure Assessment  

SciTech Connect

In a mortality study of white males who had worked at the Rocky Flats Nuclear Weapons Plant between 1952 and 1979, an increased number of deaths from benign and unspecified intracranial neoplasms was found. A case-control study nested within this cohort investigated the hypothesis that an association existed between brain tumor death and exposure to either internally deposited plutonium or external ionizing radiation. There was no statistically significant association found between estimated radiation exposure from internally deposited plutonium and the development of brain tumors. Exposure by job or work area showed no significant difference between the cohort and the control groups. An update of the study found elevated risk estimates for (1) all lymphopoietic neoplasms, and (2) all causes of death in employees with body burdens greater than or equal to two nanocuries of plutonium. There was an excess of brain tumors for the entire cohort. Similar cohort studies conducted on worker populations from other plutonium handling facilities have not yet shown any elevated risks for brain tumors. Historically, the Rocky Flats Nuclear Weapons Plant used large quantities of chemicals in their production operations. The use of solvents, particularly carbon tetrachloride, was unique to Rocky Flats. No investigation of the possible confounding effects of chemical exposures was done in the initial studies. The objectives of the present study are to (1) investigate the history of chemical use at the Rocky Flats facility; (2) locate and analyze chemical monitoring information in order to assess employee exposure to the chemicals that were used in the highest volume; and (3) determine the feasibility of establishing a chemical exposure assessment model that could be used in future epidemiology studies.

Janeen Denise Robertson

1999-02-01T23:59:59.000Z

253

Evaluation of potential modifications to the SEER (Simplified Estimation of Exposure to Radiation) fallout code. Technical report, 1 August 1982-1 August 1983  

Science Conference Proceedings (OSTI)

This report presents the methodology and results of an attempt to modify and improve the computer code SEER (Simplified Estimation of Exposure to Radiation). SEER, part of the large nuclear weapon damage-assessment code CIVIC, was developed in the early 1970s with the intent that it simulate the fallout exposure-rate contours of DELFIC (Defense Land Fallout Interpretive code) while using a minimal amount of computer time. A problem that surfaced with the development of SEER was the fact that the SEER methodology leads to an overprediction of the total activity deposited on the ground. In order to compensate for this characteristic, SAI has lowered the value of the K-factor in the SEER portion of CIVIC to approximately half of the original value. The K-factor is the amount of weapon fallout activity per unit yield, distributed over unit area. Its value is not precisely known, in part because the percentage of total radioactive debris that constitutes early fallout (as opposed to that which is lofted to high altitudes and carried off beyond local fallout distances) is not well known and varies with height of burst and other conditions. This work effort investigated the possibility of modifying the SEER methodology so that activity is conserved and a good approximation to DELFIC results could be obtained without resort to the adjustment of the K-factor.

Edwards, R.C.

1983-09-01T23:59:59.000Z

254

Development and Validation of a Heart Atlas to Study Cardiac Exposure to Radiation Following Treatment for Breast Cancer  

SciTech Connect

Purpose: Cardiac toxicity is an important sequela of breast radiotherapy. However, the relationship between dose to cardiac structures and subsequent toxicity has not been well defined, partially due to variations in substructure delineation, which can lead to inconsistent dose reporting and the failure to detect potential correlations. Here we have developed a heart atlas and evaluated its effect on contour accuracy and concordance. Methods and Materials: A detailed cardiac computed tomography scan atlas was developed jointly by cardiology, cardiac radiology, and radiation oncology. Seven radiation oncologists were recruited to delineate the whole heart, left main and left anterior descending interventricular branches, and right coronary arteries on four cases before and after studying the atlas. Contour accuracy was assessed by percent overlap with gold standard atlas volumes. The concordance index was also calculated. Standard radiation fields were applied. Doses to observer-contoured cardiac structures were calculated and compared with gold standard contour doses. Pre- and post-atlas values were analyzed using a paired t test. Results: The cardiac atlas significantly improved contour accuracy and concordance. Percent overlap and concordance index of observer-contoured cardiac and gold standard volumes were 2.3-fold improved for all structures (p < 0.002). After application of the atlas, reported mean doses to the whole heart, left main artery, left anterior descending interventricular branch, and right coronary artery were within 0.1, 0.9, 2.6, and 0.6 Gy, respectively, of gold standard doses. Conclusions: This validated University of Michigan cardiac atlas may serve as a useful tool in future studies assessing cardiac toxicity and in clinical trials which include dose volume constraints to the heart.

Feng, Mary, E-mail: maryfeng@umich.ed [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Moran, Jean M. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Koelling, Todd [Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chughtai, Aamer [Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chan, June L.; Freedman, Laura; Hayman, James A.; Jagsi, Reshma; Jolly, Shruti; Larouere, Janice; Soriano, Julie; Marsh, Robin; Pierce, Lori J. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)

2011-01-01T23:59:59.000Z

255

Route to direct multiphoton multiple ionization  

Science Conference Proceedings (OSTI)

We address the concept of direct multiphoton multiple ionization in atoms exposed to intense, short-wavelength radiation and explore the conditions under which such processes dominate over the sequential. Their contribution is shown to be quite robust, even under intensity fluctuations and interaction volume integration, and reasonable agreement with experimental data is also found.

Lambropoulos, P. [Institute of Electronic Structure and Laser, FORTH, P.O. Box 1527, GR-71110 Heraklion (Greece); Department of Physics, University of Crete, P.O. Box 2208, GR-71003 Heraklion, Crete (Greece); Kavli Institute for Theoretical Physics, Santa Barbara, California 93106 (United States); Nikolopoulos, G. M. [Institute of Electronic Structure and Laser, FORTH, P.O. Box 1527, GR-71110 Heraklion (Greece); Kavli Institute for Theoretical Physics, Santa Barbara, California 93106 (United States); Papamihail, K. G. [Department of Physics, University of Crete, P.O. Box 2208, GR-71003 Heraklion, Crete (Greece)

2011-02-15T23:59:59.000Z

256

Predicting the radiation exposure of terrestrial wildlife in the Chernobyl exclusion zone : an international comparison of approaches.  

Science Conference Proceedings (OSTI)

There is now general acknowledgement that there is a requirement to demonstrate that species other than humans are protected from anthropogenic releases of radioactivity. A number of approaches have been developed for estimating the exposure of wildlife and some of these are being used to conduct regulatory assessments. There is a requirement to compare the outputs of such approaches against available data sets to ensure that they are robust and fit for purpose. In this paper we describe the application of seven approaches for predicting the whole-body ({sup 90}Sr, {sup 137}Cs, {sup 241}Am and Pu isotope) activity concentrations and absorbed dose rates for a range of terrestrial species within the Chernobyl exclusion zone. Predictions are compared against available measurement data, including estimates of external dose rate recorded by thermoluminescent dosimeters attached to rodent species. Potential reasons for differences between predictions between the various approaches and the available data are explored.

Beresford, N. A.; Barnett, C. L.; Brown, J. E.; Cheng, J.-J.; Copplestone, D.; Gaschak, S.; Hosseini, A.; Howard, B. J.; Kamboj, S.; Nedveckaite, T.; Olyslaegers, G.; Smith, J. T.; Vives i Batlle, J.; Vives-Lynch, S.; Yu, C.; Environmental Science Division; Centre for Ecology and Hydrology; Norwegian Radiation Protection Authority; England and Wales Environment Agency; International Radioecology Lab.; Inst. of Physics, Radiation Protection,; Belgian Nuclear Research Centre; Univ. of Portsmouth; Westlakes Research Inst.

2010-06-09T23:59:59.000Z

257

Poly [1,1'-bis(ethynyl)-4,4'-biphenyl(bis-tributylphosphine)Pt(II)] solutions used as low dose ionizing radiation dosimeter  

Science Conference Proceedings (OSTI)

In this work, the effect of gamma radiation on the optical properties of polymetallayne poly[1,1'-bis(ethynyl)-4,4'-biphenyl(bis-tributylphosphine)Pt(II)] (Pt-DEBP) in chloroform solution is studied. The samples were irradiated at room temperature with doses from 0.01 Gy to 1 Gy using a {sup 60}Co gamma ray source. A new band at 420 nm is observed in the emission spectra, in superposition to the emission maximum at 398 nm, linearly dependent on dose. We propose to use the ratio of the emission amplitude bands as the dosimetric parameter. This method proved to be robust, accurate, and can be used as a dosimeter in medical applications.

Bronze-Uhle, E. S.; Graeff, C. F. O. [Department of Physics, FC-UNESP, Av. Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru (Brazil)] [Department of Physics, FC-UNESP, Av. Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru (Brazil); Batagin-Neto, A.; Fernandes, D. M. [UNESP-Univ Estadual Paulista, POSMAT-Programa de Pos-Graduacao em Ciencia e Tecnologia de Materiais, Bauru, Sao Paulo (Brazil)] [UNESP-Univ Estadual Paulista, POSMAT-Programa de Pos-Graduacao em Ciencia e Tecnologia de Materiais, Bauru, Sao Paulo (Brazil); Fratoddi, I.; Russo, M. V. [Department of Chemistry, University of Rome 'Sapienza,' P.le A. Moro 5, 00185 Rome (Italy)] [Department of Chemistry, University of Rome 'Sapienza,' P.le A. Moro 5, 00185 Rome (Italy)

2013-06-17T23:59:59.000Z

258

Ionization in Atmospheres of Brown Dwarfs and Extrasolar Planets V: Alfv\\'{e}n Ionization  

E-Print Network (OSTI)

Observations of continuous radio and sporadic X-ray emission from low-mass objects suggest they harbour localized plasmas in their atmospheric environments. For low-mass objects, the degree of thermal ionization is insufficient to qualify the ionized component as a plasma, posing the question: what ionization processes can efficiently produce the required plasma that is the source of the radiation? We propose Alfv\\'{e}n ionization as a mechanism for producing localized pockets of ionized gas in the atmosphere, having sufficient degrees of ionization ($\\geq10^{-7}$) that they constitute plasmas. We outline the criteria required for Alfv\\'{e}n ionization and demonstrate it's applicability in the atmospheres of low-mass objects such as giant gas planets, brown dwarfs and M-dwarfs for both solar and sub-solar metallicities. We find that Alfv\\'{e}n ionization is most efficient at mid to low atmospheric pressures where a seed plasma is easier to magnetize and the pressure gradients needed to drive the required neut...

Stark, Craig R; Diver, Declan A; Rimmer, Paul B

2013-01-01T23:59:59.000Z

259

Low Dose Radiation Research Program: Wide Expression of LLIR and the  

NLE Websites -- All DOE Office Websites (Extended Search)

Wide Expression of LLIR and the Biological Consequences Wide Expression of LLIR and the Biological Consequences David J. Chen Lawrence Berkeley National Laboratory Why This Project It is known that changes in gene expression alter biological effects. It is necessary to identify the specific genes that demonstrate altered expression after exposure to low doses of ionizing radiation and to determine pathways involved in DNA damage recognition, signaling, and repair that are associated with radiation-induced adaptive and bystander effects. Project Goals Identification of genes whose transcription is regulated in response to low levels of ionizing radiation Identification of the genes and communication pathways that control these responses to low dose radiation Identification of the cellular and molecular targets that influence

260

Low LET Radiation Alters the Fetal Epigenome of the Avy Mouse  

NLE Websites -- All DOE Office Websites (Extended Search)

LET Radiation Alters the Fetal Epigenome of the Avy Mouse LET Radiation Alters the Fetal Epigenome of the Avy Mouse Randy Jirtle Duke University Medical Center Abstract Exposure to high levels of ionizing radiation significantly alters the epigenome in somatic cells and gametes (Filkowski and others, 2009), yet it has not been determined if epigenomic modifications occur below 10 cGy. Epigenetic dysregulation during early development is mechanistically linked to the pathogenesis of adult-onset diseases (Jirtle and Skinner, 2007). Thus, we sought to determine whether low doses of ionizing radiation during early gestation affect susceptibility to adult-onset diseases by deregulating the establishment of DNA methylation patterns. Agouti viable yellow (Avy) mice were used to test this novel postulate because they are

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Occupational Radiation Exposure at Commercial Nuclear Power Reactors and Other Facilities 2010, Prepared for the Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, May 2012  

SciTech Connect

This report summarizes the occupational exposure data that are maintained in the U.S. Nuclear Regulatory Commission’s (NRC) Radiation Exposure Information and Reporting System (REIRS). The bulk of the information contained in the report was compiled from the 2010 annual reports submitted by five of the seven categories of NRC licensees subject to the reporting requirements of 10 CFR 20.2206. Because there are no geologic repositories for high-level waste currently licensed and no NRC-licensed low-level waste disposal facilities currently in operation, only five categories will be considered in this report. The annual reports submitted by these licensees consist of radiation exposure records for each monitored individual. These records are analyzed for trends and presented in this report in terms of collective dose and the distribution of dose among the monitored individuals. Annual reports for 2010 were received from a total of 190 NRC licensees. The summation of reports submitted by the 190 licensees indicated that 192,424 individuals were monitored, 81,961 of whom received a measurable dose. When adjusted for transient workers who worked at more than one licensee during the year, there were actually 142,471 monitored individuals and 62,782 who received a measurable dose. The collective dose incurred by these individuals was 10,617 person-rem, which represents a 12% decrease from the 2009 value. This decrease was primarily due to the decrease in collective dose at commercial nuclear power reactors, as well as a decrease in the collective dose for most of the other categories of NRC licensees. The number of individuals receiving a measurable dose also decreased, resulting in an average measurable dose of 0.13 rem for 2010. The average measurable dose is defined as the total effective dose equivalent (TEDE) divided by the number of individuals receiving a measurable dose. In calendar year 2010, the average annual collective dose per reactor for light water reactor (LWR) licensees was 83 person-rem. This represents a 14% decrease from the value reported for 2009 (96 person-rem). The decrease in collective dose for commercial nuclear power reactors was due to an 11% decrease in total outage hours in 2010. During outages, activities involving increased radiation exposure such as refueling and maintenance are performed while the reactor is not in operation. The average annual collective dose per reactor for boiling water reactors (BWRs) was 137 personrem for 35 BWRs, and 55 person-rem for 69 pressurized water reactors (PWRs). Analyses of transient individual data indicate that 29,333 individuals completed work assignments at two or more licensees during the monitoring year. The dose distributions are adjusted each year to account for the duplicate reporting of transient individuals by multiple licensees. The adjustment to account for transient individuals has been specifically noted in footnotes in the figures and tables for commercial nuclear power reactors. In 2010, the average measurable dose per individual for all licensees calculated from reported data was 0.13 rem. Although the average measurable dose per individual from data submitted by licensees was 0.13 rem, a corrected dose distribution resulted in an average measurable dose per individual of 0.17 rem.

D. E. Lewis D. A. Hagemeyer Y. U. McCormick

2012-07-07T23:59:59.000Z

262

IMPRINTED GENES & TRANSPOSITIONS: EPIGENOMIC TARGETS FOR LOW DOSE RADIATION EFFECTS  

Science Conference Proceedings (OSTI)

The overall hypothesis of this grant application is that low dose ionizing radiation (LDIR) elicits adaptive responses in part by causing heritable DNA methylation changes in the epigenome. This novel postulate was tested by determining if the level of DNA methylation at the Agouti viable yellow (A{sup vy}) metastable locus is altered, in a dose-dependent manner, by low dose radiation exposure (radiation hormesis, bringing into question the assumption that every dose of radiation is harmful. Our findings not only have significant implications concerning the mechanism of hormesis, but they also emphasize the potential importance of this phenomenon in determining human risk at low radiation doses. Since the epigenetic regulation of genes varies markedly between species, the effect of LDIR on other epigenetically labile genes (e.g. imprinted genes) in animals and humans needs to be defined.

Randy Jirtle

2012-10-11T23:59:59.000Z

263

Radiation protection for medical and allied health personnel  

SciTech Connect

With the ever-increasing use of x rays and radioactive materials, more and more persons may be exposed to ionizing radiations in the course of their work. The professional status of these individuals ranges from the highly-trained radiation specialist to the casual interdepartmental messenger. Many of these people have very little information about the possible biological effects of radiation or about the amounts which may be significant. Their attitudes toward possible exposure vary from indifference to almost pathological fear. Frequently they have questions about radiation and radiation protection practices but are reluctant or unable to seek out those who could provide answers. Their concern and interest, however, should not be ignored. This report seeks to meet their needs.

1976-01-01T23:59:59.000Z

264

Health effects models for nuclear power plant accident consequence analysis: Modifications of models resulting from recent reports on health effects of ionizing radiation  

Science Conference Proceedings (OSTI)

The Nuclear Regulatory Commission has sponsored several studies to identify and quantify the potential health effects of accidental releases of radionuclides from nuclear power plants. The most recent health effects models resulting from these efforts were published in two reports, NUREG/CR-4214, Rev. 1, Part 1 (1990) and Part 2 (1989). Several major health effects reports have been published recently that may impact the health effects models presented in these reports. This addendum to the Part 2 (1989) report, provides a review of the 1986 and 1988 reports by the United Nations Scientific Committee on the Effects of Atomic Radiation, the National Academy of Sciences/National Research Council BEAR 5 Committee report and Publication 60 of the International Commission on Radiological Protection as they relate to this report. The three main sections of this addendum discuss early occurring and continuing effects, late somatic effects, and genetic effects. The major changes to the NUREG/CR-4214 health effects models recommended in this addendum are for late somatic effects. These changes reflect recent changes in cancer risk factors that have come from longer followup and revised dosimetry in major studies like that on the Japanese A-bomb survivors. The results presented in this addendum should be used with the basic NUREG/CR-4214 reports listed above to obtain the most recent views on the potential health effects of radionuclides released accidentally from nuclear power plants. 48 refs., 4 figs., 24 tabs.

Abrahamson, S. (Wisconsin Univ., Madison, WI (United States)); Bender, M.A. (Brookhaven National Lab., Upton, NY (United States)); Boecker, B.B.; Scott, B.R. (Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.); Gilbert, E.S. (Pacific Northwest Lab., Richland, WA (United States))

1991-08-01T23:59:59.000Z

265

Apoptosis as a Mechanism for Low Dose Radiation-and Amifostine-Mediated  

NLE Websites -- All DOE Office Websites (Extended Search)

Apoptosis as a Mechanism for Low Dose Radiation- and Amifostine-Mediated Apoptosis as a Mechanism for Low Dose Radiation- and Amifostine-Mediated Chromosomal Inversion Responses Pam Sykes Flinders University and Medical Centre Abstract Low dose radiation and the chemical radioprotector amifostine have both been shown to protect cells from the immediate and delayed effects of radiation exposure. They display a number of distinct similarities including their ability to protect cells against radiation-induced DNA damage, radiation-induced cell death and metastases formation. Amifostine, which protects cells from the toxic effects of ionizing radiation, has a broad range of activities including free radical scavenging, polyamine-like DNA binding, and induction of hypoxia and redox-regulated genes. Amifostine’s ability to protect cells is often

266

Concentration of leucogenenol in the serum of dogs following their exposure to lethal $gamma$ radiation from cobalt-60  

SciTech Connect

>Three male and 3 female dogs were exposed in the AFRRI whole body irradiator to 350 rads of cobalt-60 gamma -radiation at approximately 39.5 rads/ min. Prior to and at intervals following irradiation, a sample of serum was obtained from each dog and assayed for its leucogenenol content. Before irradiation the average concentration of leucogenenol in the serum was 10.5 plus or minus 6 mu g/liter. The day after irradiation the average concentration in 5 dogs fell to 0.002 mu g/liter and in 1 dog to 1.5 mu g/liter. However, 2 days after irradiation the average concentration in all dogs was elevated to 41 plus or minus 10 mu g/liter. The concentration of leucogenenol in the serum then declined so that 7 days after irradiation it was 0.47 plus or minus 0.24 mu g/liter. Leucogenenol was not measureable (< 0.001 mu g/liter) in each dog's serum for approximately 4 days before the dog died. Individual dogs survived for from 1;3 to 20 days after irradiation. (auth)

Rice, F.A.; Chen, C.G.; Rene, A.A.

1973-12-01T23:59:59.000Z

267

Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION  

Energy.gov (U.S. Department of Energy (DOE))

General. The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

268

Gamma radiation field intensity meter  

DOE Patents (OSTI)

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

Thacker, L.H.

1994-08-16T23:59:59.000Z

269

Gamma radiation field intensity meter  

SciTech Connect

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

Thacker, Louis H. (Knoxville, TN)

1995-01-01T23:59:59.000Z

270

Gamma radiation field intensity meter  

SciTech Connect

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

Thacker, Louis H. (Knoxville, TN)

1994-01-01T23:59:59.000Z

271

Gamma radiation field intensity meter  

DOE Patents (OSTI)

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

Thacker, L.H.

1995-10-17T23:59:59.000Z

272

Construction and operation of an improved radiation calibration facility at Brookhaven National Laboratory. Environmental assessment  

Science Conference Proceedings (OSTI)

Calibration of instruments used to detect and measure ionizing radiation has been conducted over the last 20 years at Brookhaven National Laboratory`s (BNL) Radiation Calibration Facility, Building 348. Growth of research facilities, projects in progress, and more stringent Department of Energy (DOE) orders which involve exposure to nuclear radiation have placed substantial burdens on the existing radiation calibration facility. The facility currently does not meet the requirements of DOE Order 5480.4 or American National Standards Institute (ANSI) N323-1978, which establish calibration methods for portable radiation protection instruments used in the detection and measurement of levels of ionizing radiation fields or levels of radioactive surface contaminations. Failure to comply with this standard could mean instrumentation is not being calibrated to necessary levels of sensitivity. The Laboratory has also recently obtained a new neutron source and gamma beam irradiator which can not be made operational at existing facilities because of geometry and shielding inadequacies. These sources are needed to perform routine periodic calibrations of radiation detecting instruments used by scientific and technical personnel and to meet BNL`s substantial increase in demand for radiation monitoring capabilities. To place these new sources into operation, it is proposed to construct an addition to the existing radiation calibration facility that would house all calibration sources and bring BNL calibration activities into compliance with DOE and ANSI standards. The purpose of this assessment is to identify potential significant environmental impacts associated with the construction and operation of an improved radiation calibration facility at BNL.

NONE

1994-10-01T23:59:59.000Z

273

Plasmadynamics and ionization kinetics of thermionic energy conversion  

DOE Green Energy (OSTI)

To reduce the plasma arc-drop, thermionic energy conversion is studied with both analytical and numerical tools. Simplifications are made in both the plasmadynamic and ionization-recombination theories. These are applied to a scheme proposed presently using laser irradiation to enhance the ionization kinetics of the thermionic plasma and thereby reduce the arc-drop. It is also predicted that it is possible to generate the required laser light from a thermionic-type cesium plasma. The analysis takes advantage of theoretical simplifications derived for the ionization-recombination kinetics. It is shown that large laser ionization enhancements can occur and that collisional cesium recombination lasing is expected. To complement the kinetic theory, a numerical method is developed to solve the thermionic plasma dynamics. To combine the analysis of ionization-recombination kinetics with the plasma dynamics of thermionic conversion, a finite difference computer program is constructed. It is capable of solving for both unsteady and steady thermionic converter behavior including possible laser ionization enhancement or atomic recombination lasing. A proposal to improve thermionic converter performance using laser radiation is considered. In this proposed scheme, laser radiation impinging on a thermionic plasma enhances the ionization process thereby raising the plasma density and reducing the plasma arc-drop. A source for such radiation may possibly be a cesium recombination laser operating in a different thermionic converter. The possibility of this being an energy efficient process is discussed. (WHK)

Lawless, J.L. Jr.; Lam, S.H.

1982-02-01T23:59:59.000Z

274

Ionization Energy Search  

Science Conference Proceedings (OSTI)

... SI calorie-based; Select the desired type(s) of ... search for species based on ionization energy values in ... Rules for data types (step 4) (Back to search). ...

2013-07-15T23:59:59.000Z

275

ORISE Radiation Emergency Assistance Center/Training Site (REAC/TS):  

NLE Websites -- All DOE Office Websites (Extended Search)

Capabilities Capabilities REAC/TS offers medical management of radiation incidents, consultation and training in radiation emergency medicine REAC/TS staff member providing medical assistance Recognized around the world for its expertise in the medical management of radiation incidents, the Radiation Emergency Assistance Center/Training Site (REAC/TS) at the Oak Ridge Institute for Science and Education (ORISE) provides radiation incident response, consultation and preparedness training, and participates in simulation exercises to address the medical aspects of human exposure to ionizing radiation. As REAC/TS continues to establish international partnerships through education, exercises and conferences, the group is strengthening radiological emergency preparedness and response around the globe. REAC/TS

276

Radiation Field Control Manual  

Science Conference Proceedings (OSTI)

The EPRI Radiation Management Program is dedicated to reducing nuclear power plant worker personnel exposure by developing practices and technologies to increase the radiation protection of the worker, and to implement methods to reduce radiation fields. The nuclear power industry has recently implemented the RP2020 Initiative to promote positive radiation protection trends. Control of radiation fields is crucial to one of the initiative goals of reducing exposure. This manual provides the current state ...

2004-12-16T23:59:59.000Z

277

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

278

Temperature dependence of the radiation inactivation of proteins  

Science Conference Proceedings (OSTI)

The radiation inactivation method allows determination of the relative molecular mass (Mr) of proteins by exposure to high doses of ionizing radiation. The analysis by target theory of biological activity decay curves yields the size of the protein. A correction factor for Mr has been routinely used in the literature when irradiation is conducted at low temperature. Since the radiation inactivation of proteins is affected by temperature, we propose a general equation which relates Mr of a protein to D37,t, the dose in megarads at a given temperature t (in degree C) where 37% of its initial biological activity remains log Mr = 5.89 - log D37,t - 0.0028t. It is concluded that temperature affects the amount of absorbed radiation energy required to inactivate 1 mol of protein.

Beauregard, G.; Potier, M.

1985-10-01T23:59:59.000Z

279

NIST Ionizing Radiation Division 1993 - Technical Highlights  

Science Conference Proceedings (OSTI)

... The high dose rates and tight spacing preclude the use of traditional ionometric ... the polarized 3 He, and partial fabrication of a gas-handling system ...

280

Ionizing Radiation Division - 1997 Technical Highlights  

Science Conference Proceedings (OSTI)

... This PEFC experiment was performed in collaboration with Dr. Richard Bellows of Exxon Research and Engineering. A ...

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

NIST Ionizing Radiation Division 1998 - Future Directions  

Science Conference Proceedings (OSTI)

... sediments, human tissues, and ocean sediment, and is working on additional unique matrices: ashed bone, ocean shellfish, and Rocky Flats Soil-II. ...

282

NIST Ionizing Radiation Division 2000 - Technical Highlights  

Science Conference Proceedings (OSTI)

... the deuteron charge structure in atomic physics ... image lithium ion conduction in batteries have shown ... the effectiveness of future battery technologies ...

283

NIST Ionizing Radiation Division 1998 - Technical Highlights  

Science Conference Proceedings (OSTI)

... of the leaching protocol are being evaluated for selective dissolution of ... SRM 4962F will be used extensively worldwide for ground-water hydrology. ...

284

NIST Ionizing Radiation Division 1998 - Technical Highlights  

Science Conference Proceedings (OSTI)

... Some potential, technical difficulties by some of the participating laboratories include: 1) data transcription; 2) sample tracking; 3) estimation of limits ...

285

NIST Ionizing Radiation Division 1999 - Technical Highlights  

Science Conference Proceedings (OSTI)

... Institute of Metal Physics, Russia) with 29 ... researchers in polarized gas magnetic resonance ... of Low-Level Radioactivity Natural Matrix Standard ...

286

NIST Ionizing Radiation Division 1994 - Technical Highlights  

Science Conference Proceedings (OSTI)

... and quantifying radioactivity in the natural matrix standards ... counted in the NIST internal gas counting system ... fast-flux reactor in Russia has indicated ...

287

NIST Ionizing Radiation Division 2001 - Technical Highlights  

Science Conference Proceedings (OSTI)

... nuclear weapon plant near the Techa River, Urals, Russia. ... exchange, for producing the polarized 3 He gas. ... level of 240 Pu and natural U into urine ...

288

NIST Ionizing Radiation Division 1995 - Technical Highlights  

Science Conference Proceedings (OSTI)

... system so this low-density gas can be ... the speciation of radionuclides in natural matrix standard ... flux nuclear reactor in Obinsk, Russia and purified ...

289

New Facility Focuses on Improved Radiation Standards  

Science Conference Proceedings (OSTI)

... The MIRF contains a high-energy electron beam ... used in ionizing radiation treatments for cancer ... such as polymer curing and wastewater treatment. ...

290

Low Dose Radiation Program: Principal Program Contacts  

NLE Websites -- All DOE Office Websites (Extended Search)

to the Office of Biological and Environmental Research. Dr. Barcellos-Hoff's current research interests are studies of breast cancer and ionizing radiation. The goal of her...

291

Radiation Sources and Radioactive Materials (Connecticut)  

Energy.gov (U.S. Department of Energy (DOE))

These regulations apply to persons who receive, transfer, possess, manufacture, use, store, handle, transport or dispose of radioactive materials and/or sources of ionizing radiation. Some...

292

Low Dose Radiation Research Program: Alec Moreley  

NLE Websites -- All DOE Office Websites (Extended Search)

Alec Moreley Technical Abstracts 1999 Workshop: Development of PCR-Based Methods for the Detection of Mutagenic Effects of Ionizing Radiation Morley, A., Turner, D., and Sykes, P....

293

Radiation Exposure Monitoring Systems (REMS)  

NLE Websites -- All DOE Office Websites (Extended Search)

format. HEADLINES... 2012 Annual Report 2012 draft data available through the REMS query tool 2012 Submittal Notification REMS Reporting Guide, containing the required format...

294

Cross sections for short pulse single and double ionization ofhelium  

SciTech Connect

In a previous publication, procedures were proposed for unambiguously extracting amplitudes for single and double ionization from a time-dependent wavepacket by effectively propagating for an infinite time following a radiation pulse. Here we demonstrate the accuracy and utility of those methods for describing two-photon single and one-photon double ionization of helium. In particular it is shown how narrow features corresponding to autoionizing states are easily resolved with these methods.

Palacios, Alicia; Rescigno, Thomas N.; McCurdy, C. William

2007-11-27T23:59:59.000Z

295

DOE 2011 Occupational Radiation Exposure report, _Prepared for the U.S. Department of Energy, Office of Health, Safety and Security. December 2012  

Science Conference Proceedings (OSTI)

This report discusses radiation protection and dose reporting requirements, presents the 2011 occupational radiation dose data along with trends over the past 5 years, and provides instructions to submit successful as low as reasonably achievable (ALARA) projects.

Derek Hagemeyer, Yolanda McCormick

2012-12-12T23:59:59.000Z

296

Low Dose Radiation Research Program: Assessing Biological Function of DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Assessing Biological Function of DNA Damage Response Genes Assessing Biological Function of DNA Damage Response Genes Larry H. Thompson Lawrence Livermore National Laboratory Why This Project To understand the relative importance of individual DNA repair and DNA-damage response pathways to the recovery of mammalian cells after exposure to low doses of ionizing radiation (IR). This understanding may lead to better ways of setting limits on human exposure to IR. In spite of the discovery of many mammalian DNA repair genes, our current knowledge of how many of these genes contribute to cellular recovery from IR exposure is quite limited. Project Goals Measure cellular responses at doses in the 5-100 cGy range, which generally cause changes too small to detect in normal, repair-proficient cells Focus on DNA double-strand breaks (DSBs) and DNA oxidative base

297

The Association between Cancers and Low Level Radiation: an evaluation of the epidemiological evidence at the Hanford Nuclear Weapons Facility  

E-Print Network (OSTI)

date of death, internal radiation and exposure period, thedeath, death year, internal radiation, exposure period, andexposures (chemical and smoking), internal doses, and types of radiation.

Britton, Julie

2010-01-01T23:59:59.000Z

298

WI Radiation Protection  

Energy.gov (U.S. Department of Energy (DOE))

This statute seeks to regulate radioactive materials, to encourage the constructive uses of radiation, and to prohibit and prevent exposure to radiation in amounts which are or may be detrimental...

299

Low Dose Radiation Research Program: Using a Low LET Electron Microbeam to  

NLE Websites -- All DOE Office Websites (Extended Search)

a Low LET Electron Microbeam to Investigate Non-Targeted Effects of a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation William F. Morgan Radiation Oncology Research Laboratory, Pacific Northwest National Laboratory Why this Project? To examine genomic instability and bystander effects as non-targeted effects associated with low dose radiation exposure. Project Goals To provides a robust, reliable, highly sensitive assay for detecting delayed events occurring in cells exposed to low doses of ionizing radiation. Experimental Approach To mimic radiation damage from gamma and x-ray sources, a low-LET electron microbeam that generates energetic electrons has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells leaving neighboring cells unirradiated. Using a novel green fluorescence gene (GFP) reporter assay, a high through

300

Radiation protection for medical and allied health personnel-approved 1976  

SciTech Connect

With the ever-increasing use of x rays and radioactive materials, more and more persons may be exposed to ionizing radiations in the course of their work. The professional status of these individuals ranges from the highly-trained radiation specialist to the casual interdepartmental messenger. Many of these people have very little information about the possible biological effects of radiation or about the amounts which may be significant. Their attitudes toward possible exposure vary from indifference to almost pathological fear. Frequently they have questions about radiation and radiation protection practices but are reluctant or unable to seek out those who could provide answers. Their concern and interest, however, should not be ignored. This report seeks to meet their needs.

1977-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

The Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays,  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, Mechanism of Low Dose Radiation Risk Associated with Diagnostic X-rays, PET, and Gamma-rays Douglas Boreham McMaster University Abstract The goal of this project was to investigate low dose ionizing radiation effects associated with exposure to diagnostic computed tomography (CT) or positron emission tomography (PET) scans. Biological effects were evaluated in wild type and Trp53+/- heterozygous females, following in vivo exposure to diagnostic CT (75kVp, 200µ) or PET (18F-FDG) scans. The short term biological effects following CT or PET scans were evaluated in order to understand biological modification of mechanisms, such as DNA repair processes and apoptosis, that might alter long term cancer risk. Corresponding life-time cancer risk studies are in progress. Short-term

302

Low Dose Radiation Research Program: The Role of the Number and Spacing of  

NLE Websites -- All DOE Office Websites (Extended Search)

Program Workshop I Program Workshop I November 10-12, 1999, Washington, D.C. The Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation Leslie A. Braby and J. R. Ford Nuclear Engineering, Texas A&M University, 129 Zachry, College Station, Texas. Summary: Biological mechanisms, which may influence the health risks resulting from very low dose radiation exposures, will be investigated using a collimated beam of electrons to simulate the irradiation patterns occurring with low dose exposures. Abstract: Ionizing radiation produces a variety of free radicals and chemical products that react to produce the same types of oxidative damage in a mammalian cell as produced by the normal metabolic activity of the cell. However, the damage produced by radiation is distributed differently

303

The Need for Research Programs to Provide Data Applicable to the Estimate of Maximum Permissible Exposure Values for Internally Deposited Radionuclides  

SciTech Connect

The nuclear age, which has been with us slightly more than 20 years, has brought with it an unusual awareness of a relatively new toxic agent--ionizing radiation. In fact, a new science, health physics, was created to give special attention to this problem. As a consequence and in spite of the unparalleled hazards associated with ionizing radiation, this new nuclear industry is growing rapidly into a benevolent giant bringing a better way of life while at the Same time maintaining radiation damage at an insignificant level. Although i n the past few decades we have learned much more about the hazards associated with ionizing radiation than those associated with some of the common industrial hazards and although maximum permissible exposure levels for the radionuclides have been established with greater reliability and confidence than have the levels for many chemical agents with which man has been familiar for many centuries, there still remains a considerable uncertainty in many of the basic assumptions and in the parameters used in the calculation of maximum permissible body burden and maximum permissible concentration of the various radionuclides in food, water and air. There is need to determine the uptake, distribution and elimination of a variety of chemical compounds of the approximately 300 common radionuclides. These data are needed for the several modes of intake by the various age groups, and differences due to race, sex, weight, eating habits, etc., should be investigated. There is need especially to obtain data from studies of human exposure and to examine the influence of the quantity and chemical form of the radionuclide and of other associated chemical elements taken into the body, both from single exposure and from continuous exposure.

Morgan, K.Z.

1964-08-21T23:59:59.000Z

304

Role of the area postrema in radiation-induced taste aversion learning and emesis in cats  

SciTech Connect

The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dose rate of 40 rads/min) to elicit a taste aversion, and by using body-only exposures (4500 and 6000 rads at 450 rads/min) to produce emesis. Lesions of the area postrema disrupted both taste aversion learning and emesis following irradiation. These results, which indicate that the area postrema is involved in the mediation of both radiation-induced emesis and taste aversion learning in cats under these experimental conditions, are interpreted as being consistent with the hypotheses that similar mechanisms mediate both responses to exposure to ionizing radiation, and that the taste aversion learning paradigm can therefore serve as a model system for studying radiation-induced emesis.

Rabin, B.M.; Hunt, W.A.; Chedester, A.L.; Lee, J.

1986-01-01T23:59:59.000Z

305

Characterization of Thallium Bromide (TlBr) for Room Temperature Radiation Detectors  

E-Print Network (OSTI)

1.1 Motivation: Radiation Detection for HomelandSecurity . . . . . . . . . . 1.2 Semiconductor Radiationand related features of radiation ionization energies in

Smith, Holland McTyeire

2013-01-01T23:59:59.000Z

306

Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A- General Provisions  

Energy.gov (U.S. Department of Energy (DOE))

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

307

Low Dose Radiation Research Program: Ionizing Radiation-induced...  

NLE Websites -- All DOE Office Websites (Extended Search)

p53-directed, DNA damage response pathway. The p53 protein, activated indirectly by the ATM protein kinase, transactivates target genes and thus induces cell cycle progression...

308

Monte Carlo Photoionization Simulations of Diffuse Ionized Gas  

E-Print Network (OSTI)

We demonstrate that the observed increase of some nebular line ratios with height above the midplane in the diffuse ionized gas (DIG) in the Milky Way and other galaxies is a natural consequence of the progressive hardening of the radiation field far from the midplane ionizing sources. To obtain increasing temperatures and line ratios away from the midplane, our photoionization simulations of a multi-component interstellar medium do not require as much additional heating (over and above that from photoionization) as previous studies that employed one dimensional, spherically averaged models. Radiation leaking into the DIG from density bounded H II regions is generally harder in the H-ionizing continuum and has its He-ionizing photons suppressed compared to the ionizing source of the H II region. In line with other recent investigations, we find that such leaky H II region models can provide elevated temperatures and line ratios, and a lower He+ fraction in the DIG. For a composite model representing the relative spectral types of O stars in the solar neighbourhood, we find that additional heating less than 1.0E-26 n_e ergs/s/cm^3 can reproduce the observed elevated line ratios in the DIG. This additional heating is considerably less than previous estimates due to the natural hardening of the radiation field reaching large heights in our simulations.

Kenneth Wood; John S. Mathis

2004-02-17T23:59:59.000Z

309

Rayleigh-Taylor Instability at Ionization Fronts: Perturbation Analysis  

E-Print Network (OSTI)

The linear growth rate of the Rayleigh-Taylor instability (RTI) at ionization fronts is investigated via perturbation analysis in the limit of incompressible fluids. In agreement with previous numerical studies is found that absorption of ionizing radiation inside the HII region due to hydrogen recombinations suppresses the growth of instabilities. In the limit of a large density contrast at the ionization front the RTI growth rate has the simple analytical solution n=-nur+(nur^2+gk)^(1/2), where nur is the hydrogen recombination rate inside the HII region, k is the perturbation's wavenumber and g is the effective acceleration in the frame of reference of the front. Therefore, the growth of surface perturbations with wavelengths lambda >> lambda_{cr} = 2\\pi g/nur^2 is suppressed by a factor (lambda_{cr}/4lambda)^(1/2) with respect to the non-radiative incompressible RTI. Implications on stellar and black hole feedback are briefly discussed.

Ricotti, Massimo

2013-01-01T23:59:59.000Z

310

Radiation Safety Manual Dec 2012 Page 1 RADIATION SAFETY  

E-Print Network (OSTI)

. Management Commitment B. Training C. Monitoring of Individual Radiation Exposures D. Program Reviews 1 of Radiation A. Research Applications 1. Non-Human User 2. Animal Use 3. Human Use B. Clinical Applications C Materials Chapter VI: Occupational Exposure to Radiation and Personnel Monitoring and Bioassay Program #12;A

Grishok, Alla

311

Low Dose Radiation Research Program: Role of TNF-α as a Potential  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of TNF-α as a Potential Signaling Mediator of Role of TNF-α as a Potential Signaling Mediator of Radiation-Induced Bystander Effect in Human Vascular Cells. Authors: Mohan Natarajan, Sumathy Mohan, Catherine Gibbons, Yan Bo and Munira A. Kadhim Institutions: Departments of Radiation Oncology and Pathology, University of Texas Health Science Center, San Antonio, Texas; Environmental Toxicology Graduate Program, University of California, Riverside; Radiation and Genomic Stability Unit, Medical research Council, Oxford, United Kingdom Identifying reliable and sensitive signaling pathways that are implicated in adverse health effects after exposure to low doses of ionizing radiation would allow us to understand the scientific basis of low dose-induced signaling pathways and their downstream phenotypic expression. This

312

Cell type dependent radiation induced signaling and its effect on tissue regulation  

NLE Websites -- All DOE Office Websites (Extended Search)

Cell type dependent radiation induced signaling and its effect on tissue regulation Cell type dependent radiation induced signaling and its effect on tissue regulation Marianne B. Sowa, Claere von Neubeck, R. Joe Robinson, Paula M. Koehler, Norman J. Karin, Xihai Wang, Katrina M. Waters and Harish Shankaran Ionizing radiation exposure triggers a cell signaling program which includes proliferation, the DNA damage response, and tissue remodeling. The activated signaling pathways lead to the induction of both protective effects as well as adverse consequences. A fundamental question is whether signaling cascades initiated by low doses are fundamentally different than those initiated by high doses. To address this question we have applied a systems biology approach to examine the radiation induced temporal responses of an in vitro three dimensional (3D) human skin tissue model. Using microarray-

313

Semiconductor radiation detector  

DOE Patents (OSTI)

A semiconductor detector for ionizing electromagnetic radiation, neutrons, and energetic charged particles. The detecting element is comprised of a compound having the composition I-III-VI.sub.2 or II-IV-V.sub.2 where the "I" component is from column 1A or 1B of the periodic table, the "II" component is from column 2B, the "III" component is from column 3A, the "IV" component is from column 4A, the "V" component is from column 5A, and the "VI" component is from column 6A. The detecting element detects ionizing radiation by generating a signal proportional to the energy deposited in the element, and detects neutrons by virtue of the ionizing radiation emitted by one or more of the constituent materials subsequent to capture. The detector may contain more than one neutron-sensitive component.

Bell, Zane W. (Oak Ridge, TN); Burger, Arnold (Knoxville, TN)

2010-03-30T23:59:59.000Z

314

Scintillator Waveguide For Sensing Radiation  

DOE Patents (OSTI)

The present invention is an apparatus for detecting ionizing radiation, having: a waveguide having a first end and a second end, the waveguide formed of a scintillator material wherein the therapeutic ionizing radiation isotropically generates scintillation light signals within the waveguide. This apparatus provides a measure of radiation dose. The apparatus may be modified to permit making a measure of location of radiation dose. Specifically, the scintillation material is segmented into a plurality of segments; and a connecting cable for each of the plurality of segments is used for conducting scintillation signals to a scintillation detector.

Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder; Paul L. (Richland, WA)

2003-04-22T23:59:59.000Z

315

The Effects of Ionizing Irradiation  

Science Conference Proceedings (OSTI)

Page 1. The Effects of Ionizing Irradiation on Liquid, Dried, and Absorbed DNA Extracts ... Page 12. Study Shipped Land Carrier Irradiation ? ...

2012-02-29T23:59:59.000Z

316

Low Dose Radiation Research Program: 2011 Current Projects  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains...

317

Low Dose Radiation Research Program: Depletion of the Vertebrate...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory, Berkeley, California To better understand the responses to low dose ionizing radiation, we proposed in Aim 1 of our Low Dose grant to use dominant-negative...

318

Low Dose Radiation Research Program: Proteomic and Biochemical...  

NLE Websites -- All DOE Office Websites (Extended Search)

proteomic changes including protein expression levels and post-translational modification due to low dose-rate ionizing radiation Expected Outcomes Increased differentiation...

319

Monte Carlo Photoionization Simulations of Diffuse Ionized Gas  

E-Print Network (OSTI)

We demonstrate that the observed increase of some nebular line ratios with height above the midplane in the diffuse ionized gas (DIG) in the Milky Way and other galaxies is a natural consequence of the progressive hardening of the radiation field far from the midplane ionizing sources. To obtain increasing temperatures and line ratios away from the midplane, our photoionization simulations of a multi-component interstellar medium do not require as much additional heating (over and above that from photoionization) as previous studies that employed one dimensional, spherically averaged models. Radiation leaking into the DIG from density bounded H II regions is generally harder in the H-ionizing continuum and has its He-ionizing photons suppressed compared to the ionizing source of the H II region. In line with other recent investigations, we find that such leaky H II region models can provide elevated temperatures and line ratios, and a lower He+ fraction in the DIG. For a composite model representing the relat...

Wood, K; Wood, Kenneth; Mathis, John S.

2004-01-01T23:59:59.000Z

320

Fundamentals of health physics for the radiation-protection officer  

SciTech Connect

The contents of this book on health physics include chapters on properties of radioactive materials, radiation instrumentation, radiation protection programs, radiation survey programs, internal exposure, external exposure, decontamination, selection and design of radiation facilities, transportation of radioactive materials, radioactive waste management, radiation accidents and emergency preparedness, training, record keeping, quality assurance, and appraisal of radiation protection programs. (ACR)

Murphy, B.L.; Traub, R.J.; Gilchrist, R.L.; Mann, J.C.; Munson, L.H.; Carbaugh, E.H.; Baer, J.L.

1983-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

"We will die and become science" : the production of invisibility and public knowledge about Chernobyl radiation effects in Belarus  

E-Print Network (OSTI)

external radiation exposure and internal accumulation ofinternal accumulation), or it might (incorrectly) refer to external radiation exposure.radiation exposure should not be forgotten. Patients, for example, can be checked for their internal

Kuchinskaya, Olga

2007-01-01T23:59:59.000Z

322

ESTIMATING HISTORICAL TRICHLOROETHYLENE EXPOSURE IN A URANIUM ENRICHMENT, GASEOUS DIFFUSION PLANT.  

E-Print Network (OSTI)

??Previous studies at two uranium enrichment plants have looked at radiation exposures, but not an extensive list of chemical exposures, limiting evaluation of potential interactions.… (more)

MOSER, ADRIANE

2005-01-01T23:59:59.000Z

323

Third-harmonic generation and multiphoton ionization spectroscopy  

SciTech Connect

Nonlinear phenomena, such as multiphoton excitation (MPE) processes leading to ionization and third-harmonic generation (THG) in gases have become the issue of extensive studies over recent years. Studies in rare gases in particular have resulted in several interesting observations in this respect. Thus, it has been established that three-photon resonantly enhanced multiphoton ionization (MPI) in the vicinity of states which are single photon optically coupled to the ground state may occur in efficient competition with THG. The present work demonstrates several new effects which may appear when third-harmonic radiation is present during MPI.

Fotakis, C.; Stockdale, J.A.D.; Proctor, M.J.

1987-01-01T23:59:59.000Z

324

Partially Ionized Atmospheres of Neutron Stars with Strong Magnetic Fields  

DOE Green Energy (OSTI)

We construct hydrogen atmosphere models for strongly magnetized neutron stars in thermodynamic equilibrium, taking into account partial ionization. The presence of bound states affects the equation of state, absorption coefficients, and polarizability tensor of a strongly magnetized plasma. Therefore the partial ionization influences the polarization vectors and opacities of normal electromagnetic waves, and thus the spectra of outgoing radiation. Here we review a model suitable for the most typical neutron-star atmospheres and focus on the problems that remain to be solved for its extension to other atmospheric parameters.

Potekhin, A.

2005-01-28T23:59:59.000Z

325

Living with radiation  

SciTech Connect

The authors present an account of the hopes and fears associated with ionizing radiation, extending from nuclear energy and medical radiation to nuclear weapons. They argue that a justified fear of nuclear weapons has led to a widespread, unjustified, and unreasoning fear of the beneficial applications of radiation. Although these two aspects of atomic energy are tied together-they both involve the nucleus of the atom and its radioactive rays-a deep misunderstanding of this relationship by the general public has evolved since the time of the atomic bombing of Hiroshima and Nagasaki. The authors' aim is to place the beneficial applications of nuclear radiation in perspective.

Wagner, H.N. Jr. (Johns Hopkins Medical Institutions, Baltimore, MD (USA). Div. of Nuclear Medicine); Ketchum, L.E. (Proclinica, Inc., New York, NY (US))

1989-01-01T23:59:59.000Z

326

SOFT LASER DESORPTION IONIZATION -MALDI, DIOS AND NANOSTRUCTURES  

E-Print Network (OSTI)

absorbs the laser energy. Upon exposure to pulsed laser radiation, the ensuing phase transition initiates other competing processes that elevate the internal energy of the adsorbate and results in its radiation succeeded (Tanaka, et al., 1988; Karas and Hillenkamp, 1988). As a result, during the past decade

Vertes, Akos

327

EFFECTS OF TRITIUM EXPOSURE ON UHMW-PE, PTFE, AND VESPEL  

DOE Green Energy (OSTI)

Samples of three polymers, Ultra-High Molecular Weight Polyethylene (UHMW-PE), polytetrafluoroethylene (PTFE, also known as Teflon{reg_sign}), and Vespel{reg_sign} polyimide were exposed to 1 atmosphere of tritium gas at ambient temperature for varying times up to 2.3 years in closed containers. Sample mass and size measurements (to calculate density), spectra-colorimetry, dynamic mechanical analysis (DMA), and Fourier-transform infrared spectroscopy (FT-IR) were employed to characterize the effects of tritium exposure on these samples. Changes of the tritium exposure gas itself were characterized at the end of exposure by measuring total pressure and by mass spectroscopic analysis of the gas composition. None of the polymers exhibited significant changes of density. The color of initially white UHMW-PE and PTFE dramatically darkened to the eye and the color also significantly changed as measured by colorimetry. The bulk of UHMW-PE darkened just like the external surfaces, however the fracture surface of PTFE appeared white compared to the PTFE external surfaces. The white interior could have been formed while the sample was breaking or could reflect the extra tritium dose at the surface directly from the gas. The dynamic mechanical response of UHMW-PE was typical of radiation effects on polymers- an initial stiffening (increased storage modulus) and reduction of viscous behavior after three months exposure, followed by lowering of the storage modulus after one year exposure and longer. The storage modulus of PTFE increased through about nine months tritium exposure, then the samples became too weak to handle or test using DMA. Characterization of Vespel{reg_sign} using DMA was problematic--sample-to-sample variations were significant and no systematic change with tritium exposure could be discerned. Isotopic exchange and incorporation of tritium into UHMW-PE (exchanging for protium) and into PTFE (exchanging for fluorine) was observed by FT-IR using an attenuated total reflectance method. No significant change in the Vespel{reg_sign} infrared spectrum was observed after three months exposure. Protium significantly pressurized the UHMW-PE containers during exposure to about nine atmospheres (the initial pressure was one atmosphere of tritium). This is consistent with the well-known production of hydrogen by irradiation of polyethylene by ionizing radiation. The total pressure in the PTFE containers decreased, and a mass balance reveals that the observed decrease is consistent with the formation of small amounts of {sup 3}HF, which is condensed at ambient temperature. No significant change of pressure occurred in the Vespel{reg_sign} containers; however the composition of the gas became about 50% protium, showing that Vespel{reg_sign} interacted with the tritium gas atmosphere to some degree. The relative resistance to degradation from tritium exposure is least for PTFE, more for UHMW-PE, and the most for Vespel{reg_sign}, which is consistent with the known relative resistance of these polymers to gamma irradiation. This qualitatively agrees with the concept of equivalent effects for equivalent absorbed doses of radiation damage of polymers. Some of the changes of different polymers are qualitatively similar; however each polymer exhibited unique property changes when exposed to tritium. Information from this study that can be applied to a tritium facility is: (1) the relative resistance to tritium degradation of the three polymers studied is the same as the relative resistance to gamma irradiation in air (so relative rankings of polymer resistance to ionizing radiation can be used as a relative ranking for assessing tritium compatibility and polymer selection); and (2) all three polymers changed the gas atmosphere during tritium exposure--UHMW-PE and Vespel{reg_sign} exposed to tritium formed H{sub 2} gas (UHMW-PE much more so), and PTFE exposed to tritium formed {sup 3}HF. This observation of forming {sup 3}HF supports the general concept of minimizing chlorofluorocarbon polymers in tritium systems.

Clark, E; Kirk Shanahan, K

2006-05-31T23:59:59.000Z

328

High pressure xenon ionization detector  

DOE Patents (OSTI)

A method is provided for detecting ionization comprising allowing particles that cause ionization to contact high pressure xenon maintained at or near its critical point and measuring the amount of ionization. An apparatus is provided for detecting ionization, the apparatus comprising a vessel containing a ionizable medium, the vessel having an inlet to allow high pressure ionizable medium to enter the vessel, a means to permit particles that cause ionization of the medium to enter the vessel, an anode, a cathode, a grid and a plurality of annular field shaping rings, the field shaping rings being electrically isolated from one another, the anode, cathode, grid and field shaping rings being electrically isolated from one another in order to form an electric field between the cathode and the anode, the electric field originating at the anode and terminating at the cathode, the grid being disposed between the cathode and the anode, the field shaping rings being disposed between the cathode and the grid, the improvement comprising the medium being xenon and the vessel being maintained at a pressure of 50 to 70 atmospheres and a temperature of 0.degree. to 30.degree. C.

Markey, John K. (New Haven, CT)

1989-01-01T23:59:59.000Z

329

High pressure xenon ionization detector  

DOE Patents (OSTI)

A method is provided for detecting ionization comprising allowing particles that cause ionization to contact high pressure xenon maintained at or near its critical point and measuring the amount of ionization. An apparatus is provided for detecting ionization, the apparatus comprising a vessel containing a ionizable medium, the vessel having an inlet to allow high pressure ionizable medium to enter the vessel, a means to permit particles that cause ionization of the medium to enter the vessel, an anode, a cathode, a grid and a plurality of annular field shaping rings, the field shaping rings being electrically isolated from one another, the anode, cathode, grid and field shaping rings being electrically isolated from one another in order to form an electric field between the cathode and the anode, the electric field originating at the anode and terminating at the cathode, the grid being disposed between the cathode and the anode, the field shaping rings being disposed between the cathode and the grid, the improvement comprising the medium being xenon and the vessel being maintained at a pressure of 50 to 70 atmospheres and a temperature of 0 to 30 C. 2 figs.

Markey, J.K.

1989-11-14T23:59:59.000Z

330

Low Dose Radiation Program: Links - Organizations Conducting Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Conducting Low Dose Radiation Research Conducting Low Dose Radiation Research DOE Low Dose Radiation Research Program DoReMi Integrating Low Dose Research High Level Expert Group (HLEG) on European Low Dose Risk Research Multidisciplinary European Low Dose Initiative (MELODI) RISC-RAD Radiosensitivity of Individuals and Susceptibility to Cancer induced by Ionizing Radiation United States Transuranium & Uranium Registries Organizations Conducting other Radiation Research Argonne National Laboratory (ANL) Armed Forces Radiology Research Institute (AFRRI) Atmospheric Radiation Measurement (ARM) Program Brookhaven National Laboratory (BNL) Center for Devices and Radiological Health (CDRH) Central Research Institute of Electric Power Industry (CRIEPI) Colorado State University Columbia University

331

Ionization of hydrogen and ionized helium by slow antiprotons  

E-Print Network (OSTI)

We study the ionization process involving antiproton and hydrogen in the energy range between 0.1 keV to 500 keV, using single center close coupling approximation. We construct the scattering wave function using B-spline bases. The results obtained for ionization of atomic hydrogen are compared with other existing theoretical calculations as well as with the available experimental data. The present results are found to be encouraging. We also employed this method to study the ionization of ionized helium in the energy range between 1 and 500 keV. On comparision, the present results are found to interpret well the cross section values calculated using other theories.

Sahoo, S; Walters, H R J

2004-01-01T23:59:59.000Z

332

Pulsed helium ionization detection system  

DOE Patents (OSTI)

A helium ionization detection system is provided which produces stable operation of a conventional helium ionization detector while providing improved sensitivity and linearity. Stability is improved by applying pulsed dc supply voltage across the ionization detector, thereby modifying the sampling of the detectors output current. A unique pulse generator is used to supply pulsed dc to the detector which has variable width and interval adjust features that allows up to 500 V to be applied in pulse widths ranging from about 150 nsec to about dc conditions.

Ramsey, R.S.; Todd, R.A.

1985-04-09T23:59:59.000Z

333

Optical ionization detector  

DOE Patents (OSTI)

An optical ionization detector wherein a beam of light is split so that one arm passes through a fiber optics and the other arm passes through a gas-filled region, and uses interferometry to detect density changes in a gas when charged particles pass through it. The gas-filled region of the detector is subjected to a high electric field and as a charged particle traverses this gas region electrons are freed from the cathode and accelerated so as to generate an electron avalanche which is collected on the anode. The gas density is effected by the electron avalanche formation and if the index or refraction is proportional to the gas density the index will change accordingly. The detector uses this index change by modulating the one arm of the split light beam passing through the gas, with respect to the other arm that is passed through the fiber optic. Upon recombining of the beams, interference fringe changes as a function of the index change indicates the passage of charged particles through the gaseous medium.

Wuest, Craig R. (Danville, CA); Lowry, Mark E. (Castro Valley, CA)

1994-01-01T23:59:59.000Z

334

Optical ionization detector  

DOE Patents (OSTI)

An optical ionization detector wherein a beam of light is split so that one arm passes through a fiber optics and the other arm passes through a gas-filled region, and uses interferometry to detect density changes in a gas when charged particles pass through it. The gas-filled region of the detector is subjected to a high electric field and as a charged particle traverses this gas region electrons are freed from the cathode and accelerated so as to generate an electron avalanche which is collected on the anode. The gas density is effected by the electron avalanche formation and if the index or refraction is proportional to the gas density the index will change accordingly. The detector uses this index change by modulating the one arm of the split light beam passing through the gas, with respect to the other arm that is passed through the fiber optic. Upon recombining of the beams, interference fringe changes as a function of the index change indicates the passage of charged particles through the gaseous medium. 3 figures.

Wuest, C.R.; Lowry, M.E.

1994-03-29T23:59:59.000Z

335

Novel target configurations for selective ionization state studies in molybdenum  

Science Conference Proceedings (OSTI)

Details of experiments aimed at achieving low ionization state selectivity in molybdenum are presented. Targets are excited with a 10 J CO{sub 2} laser and the resultant VUV spectrum (300--700 {Angstrom}) has been studied. Combinations of focal spot size, target depth, and target geometries are compared. Simple attenuation of energy is shown not to vary ionization stage composition significantly. Experiments conducted with grazing incidence targets result only in a hot plasma. Modular targets with cooling cylinders of various radii demonstrated good selectivity of the ionization states, but with low absolute signals. Finally, results from combinations of focal spot adjustment and radiative cooling illustrate increased control over desired plasma temperature and density for spectroscopic studies of molybdenum. 7 refs., 14 figs.

Ilcisin, K.J.; Feldman, U.; Schwob, J.L.; Wouters, A. (Princeton Univ., NJ (USA). Plasma Physics Lab.); Suckewer, S. (Princeton Univ., NJ (USA). Plasma Physics Lab. Princeton Univ., NJ (USA). Dept. of Mechanical and Aerospace Engineering)

1990-03-01T23:59:59.000Z

336

The One Million U.S. Radiation Worker Study  

NLE Websites -- All DOE Office Websites (Extended Search)

for chronic radiation exposure. Much knowledge has been gained from the study of atomic bomb survivors, but exposure was acute and 2 among a Japanese population living in...

337

Radiation doses for Marshall Islands Atolls Affected by U.S. Nuclear Testing:All Exposure Pathways, Remedial Measures, and Environmental Loss of 137Cs  

SciTech Connect

The United States conducted 24 nuclear tests at Bikini Atoll with a total yield of 76.8 Megatons (MT). The Castle series produced about 60% of this total and included the Bravo test that was the primary source of contamination of Bikini Island and Rongelap and Utrok Atolls. One of three aerial drops missed the atoll and the second test of the Crossroads series, the Baker test, was an underwater detonation. Of the rest, 17 were on barges on water and 3 were on platforms on an island; they produced most of the contamination of islands at the atoll. There were 42 tests conducted at Enewetak Atoll with a total yield of 31.7 MT (Simon and Robison, 1997; UNSCEAR, 2000). Of these tests, 18 were on a barge over wateror reef, 7 were surface shots, 2 aerial drops, 2 under water detonations, and 13 tower shots on either land or reef. All produced some contamination of various atoll islands. Rongelap Atoll received radioactive fallout as a result of the Bravo test on March 1, 1954 that was part of the Castle series of tests. This deposition was the result of the Bravo test producing a yield of 15 MT, about a factor of three to four greater than the predicted yield that resulted in vaporization of more coral reef and island than expected and in the debris-cloud reaching a much higher altitude than anticipated. High-altitude winds were to the east at the time of detonation and carried the debris-cloud toward Rongelap Atoll. Utrok Atoll also received fallout from the Bravo test but at much lower air and ground-level concentrations than at Rongelap atoll. Other atolls received Bravo fallout at levels below that of Utrok [other common spellings of this island and atoll (Simon, et al., 2009)]. To avoid confusion in reading other literature, this atoll and island are spelled in a variety of ways (Utrik, Utirik, Uterik or Utrok). Dose assessments for Bikini Island at Bikini Atoll (Robison et al., 1997), Enjebi Island at Enewetak Atoll (Robison et al., 1987), Rongelap Island at Rongelap Atoll (Robison et al., 1994; Simon et al., 1997), and Utrok Island at Utrok Atoll (Robison, et al., 1999) indicate that about 95-99% of the total estimated dose to people who may return to live at the atolls today (Utrok Island is populated) is the result of exposure to {sup 137}Cs. External gamma exposure from {sup 137}Cs in the soil accounts for about 10 to 15% of the total dose and {sup 137}Cs ingested during consumption of local food crops such as drinking coconut meat and fluid (Cocos nucifera L.), copra meat and milk, Pandanus fruit, and breadfruit accounts for about 85 to 90%. The other 1 to 2% of the estimated dose is from {sup 90}Sr, {sup 239+240}Pu, and {sup 241}Am. The {sup 90}Sr exposure is primarily through the food chain while the exposure to {sup 239+240}Pu, and {sup 241}Am is primarily via the inhalation pathway as a result of breathing re-suspended soil particles.

Robison, W L; Hamilton, T F

2009-04-20T23:59:59.000Z

338

Low Dose Radiation Research Program: DNA Damage in Acutely Irradiated F2  

NLE Websites -- All DOE Office Websites (Extended Search)

DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal F0 Germline Irradiation Authors: J.E. Baulch and O.G. Raabe Institutions: Center for Health and the Environment, University of California, Davis, CA. The main goal of this grant is to evaluate heritable, transgenerational effects of low dose, low-linear-energy-transfer (LET) radiation (0.1 Gy attenuated 137Cs gamma rays) on Type B spermatogonia in 129SVE mice; wild-type and heterozygous for Ataxia-telangiectasia (AT). The ATM heterozygotes are carriers for a genetic mutation (AT mutated, ATM) that is thought to predispose both humans and mice to radiation sensitivity. Experiments conducted in our laboratory have demonstrated heritable effects of paternal germline exposure to ionizing radiation in mice using 1.0 Gy of

339

The cohort of the atomic bomb survivors major basis of radiation safety regulations  

E-Print Network (OSTI)

Since 1950 about 87 000 A-bomb survivors from Hiroshima and Nagasaki have been monitored within the framework of the Life Span Study, to quantify radiation-induced late effects. In terms of incidence and mortality, a statistically significant excess was found for leukemia and solid tumors. In another major international effort, neutron and gamma radiation doses were estimated, for those survivors (Dosimetry System DS02). Both studies combined allow the deduction of risk coefficients that serve as a basis for international safety regulations. As an example, current results on all solid tumors combined suggest an excess relative risk of 0.47 per Sievert for an attained age of 70 years, for those who were exposed at an age of 30 years. After exposure to an effective dose of one Sievert the solid tumor mortality would thus be about 50% larger than that expected for a similar cohort not exposed to any ionizing radiation from the bombs.

Rühm, W; Nekolla, E A

2006-01-01T23:59:59.000Z

340

Low Dose Radiation Research Program: Modeling the Physics of Damage Cluster  

NLE Websites -- All DOE Office Websites (Extended Search)

Modeling the Physics of Damage Cluster Formation in a Cellular Environment Modeling the Physics of Damage Cluster Formation in a Cellular Environment Larry Toburen East Carolina University Why This Project Modern tools of radiobiology are leading to many new discoveries regarding how cells and tissues respond to radiation exposure. We can now irradiate single cells and observe responses in adjacent cells. We can also measure clusters of radiation damage produced in DNA. The primary tools available to describe the initial spatial pattern of damage formed by the absorption of ionizing radiation are based on (MC) Monte Carlo simulations of the structure of charged particle tracks. Although many MC codes exist and considerable progress is being made in the incorporation of detailed macromolecular target structures into these codes, much of the interaction

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Radiation-Induced Bystander Effects and Relevance to Human Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Bystander Effects and Relevance to Human Radiation Radiation-Induced Bystander Effects and Relevance to Human Radiation Exposures Review of phenomenon appears in Radiation Research Pamela Sykes and Benjamin Blyth One concern of radiobiologists is the effect radiation exposure might have on nearby unirradiated cells. For example, when only a small fraction of cells are directly hit by radiation energy, are the surrounding unirradiated cells also at an increased risk of cancer? The term "radiation-induced bystander effect" is used to describe radiation-induced biological changes that occur in unirradiated cells within an irradiated cell population. Radiation-induced bystander effects have become established in the vernacular and are considered as an authentic radiation response. However, there is still no consensus on a precise definition of the term, which

342

Field ionization from carbon nanofibers  

E-Print Network (OSTI)

The Micro Gas Analyzer project aims to develop power-efficient, high resolution, high sensitivity, portable and real-time gas sensors. We developed a field ionizer array based on gated CNTs. Arrays of CNTs are used because ...

Adeoti, Bosun J

2008-01-01T23:59:59.000Z

343

Humidity effects in ionization chambers  

SciTech Connect

Capacitance variations due to humidity alterations have been suggested as the cause of ionization chamber current variations. The validity of the arguments is seriously questioned on several points. (auth)

Bengtsson, L.G.

1973-01-01T23:59:59.000Z

344

Analysis of radiation exposure - service personnel on Rongerik Atoll: Operation Castle - Shot Bravo. Technical report, 12 March 1985-12 June 1987  

Science Conference Proceedings (OSTI)

External and internal doses are reconstructed for the 28 American servicemen stationed on Rongerik Atoll, Marshall Islands, who were exposed to fallout on 1-2 March 1954 from Shot Bravo of Operation CASTLE. External doses are determined from limited radiation survey and film-badge information. Internal-dose commitments are derived from urinalysis data. The magnitude of the calculated activity intake suggests the principal pathways. Reconstructed film-badge doses are approximately 40 rem, with adjustments from individual activity scenarios, as available. Internal dose commitments to the thyroid and large intestine (nearly all first-year dose) provide the only significant increments to the external dose. Total doses are approximately 230 rem to the thyroid, 115 rem to the lower large intestine, 85 rem to the upper large intestine, and about 40 to 50 rem to all other organs.

Goetz, J.; Klemm, J.; Phillips, J.; Thomas, C.

1987-07-09T23:59:59.000Z

345

Amplifier Design for Proportional Ionization Chambers  

SciTech Connect

This paper presents the requirements of a nuclear amplifier of short resolving time, designed to accept pulses of widely varying amplitudes. Data are given which show that a proportional ionization chamber loaded with a 1,000-ohm resistor develops pulses of 0.5 microsecond duration and several volts amplitude. Results indicate that seven basic requirements are imposed on the amplifier when counting soft beta and gamma radiation in the presence of alpha particles, without absorbers. It should, (1) have a fast recovery time, (2) have a relatively good low frequency response, (3) accept pulses of widely varying heights without developing spurious pulsed, (4) have a limiting output stage, (5) preserve the inherently short rise time of the chamber, (6) minimize pulse integration, and (7) have sufficient gain to detect the weak pulses well below the chamber voltage at which continuous discharge takes place. The results obtained with an amplifier which meets these requirements is described. A formula is derived which indicates that redesign of the proportional ionization chamber might eliminate the need for an amplifier. This may be possible if the radioactive particles are collimated parallel to the collecting electrode.

Baker, W. H.

1950-08-24T23:59:59.000Z

346

Rayleigh-Taylor Instability of Ionization Front around Black Holes  

E-Print Network (OSTI)

We examine the role of ionizing radiation emitted from black holes (BHs) in suppressing the growth of the Rayleigh-Taylor instability (RTI) across the ionization front (I-front) that forms when the gas fueling the BH is neutral. We use radiation-hydrodynamic simulations to show that the RTI is suppressed for non-accelerating fronts on all scales resolved in our simulations. A necessary condition for the stability of the I-front is that the radius of the Str\\"omgren sphere is larger than the Bondi radius. When this condition is violated the I-front collapses producing an accretion luminosity burst. Transient growth of the RTI occurs only during the accretion burst when the effective acceleration in the frame of reference of the I-front increases significantly due to the rapid expansion of the Str\\"omgren sphere.

Park, KwangHo; Di Matteo, Tiziana; Reynolds, Christopher S

2013-01-01T23:59:59.000Z

347

ORISE: Worker Health Studies - Beryllium Exposure Studies and...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy Radiation Exposure Monitoring System (REMS) DOE IISP 10-Year Summary Report Resources Overview Reports Peer-Reviewed Journal Articles Human Subjects Resource Book...

348

RADIATION SAFETY POLICY Effective Date: April 4, 2012 Originating Office: Office of the  

E-Print Network (OSTI)

radiation exposure "As Low as Reasonably Achievable" "Internal Radiation Permit" ("IRP") means and the general public from unnecessary or potentially harmful levels of radiation exposure. PURPOSE capable of generating X or Gamma radiation "Radiology" involves external exposure of humans to Radiation

Doedel, Eusebius

349

Low Dose Radiation Research Program: Molecular Characterization...  

NLE Websites -- All DOE Office Websites (Extended Search)

the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Radiation Chaun-Yuan Li Duke University Medical Center Durham, NC Why this Project? To evaluate the roles...

350

Optical Measurement Technologies for High Temperature, Radiation Exposure, and Corrosive Environments—Significant Activities and Findings: In-vessel Optical Measurements for Advanced SMRs  

Science Conference Proceedings (OSTI)

Development of advanced Small Modular Reactors (aSMRs) is key to providing the United States with a sustainable, economically viable, and carbon-neutral energy source. The aSMR designs have attractive economic factors that should compensate for the economies of scale that have driven development of large commercial nuclear power plants to date. For example, aSMRs can be manufactured at reduced capital costs in a factory and potentially shorter lead times and then be shipped to a site to provide power away from large grid systems. The integral, self-contained nature of aSMR designs is fundamentally different than conventional reactor designs. Future aSMR deployment will require new instrumentation and control (I&C) architectures to accommodate the integral design and withstand the extreme in-vessel environmental conditions. Operators will depend on sophisticated sensing and machine vision technologies that provide efficient human-machine interface for in-vessel telepresence, telerobotic control, and remote process operations. The future viability of aSMRs is dependent on understanding and overcoming the significant technical challenges involving in-vessel reactor sensing and monitoring under extreme temperatures, pressures, corrosive environments, and radiation fluxes

Anheier, Norman C.; Cannon, Bret D.; Qiao, Hong (Amy); Suter, Jonathan D.

2012-09-01T23:59:59.000Z

351

Neutron And Gamma Detector Using An Ionization Chamber With An Integrated  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutron And Gamma Detector Using An Ionization Chamber Neutron And Gamma Detector Using An Ionization Chamber Neutron And Gamma Detector Using An Ionization Chamber With An Integrated Body And Moderator A detector for detecting neutrons and gamma radiation includes a cathode that defines an interior surface and an interior volume. Available for thumbnail of Feynman Center (505) 665-9090 Email Neutron And Gamma Detector Using An Ionization Chamber With An Integrated Body And Moderator A detector for detecting neutrons and gamma radiation includes a cathode that defines an interior surface and an interior volume. A conductive neutron-capturing layer is disposed on the interior surface of the cathode and a plastic housing surrounds the cathode. A plastic lid is attached to the housing and encloses the interior volume of the cathode forming an

352

Numerical simulation of the pre-ionization processes during nanosecond-pulse discharge in nitrogen  

Science Conference Proceedings (OSTI)

The pre-ionization of nitrogen gas by high-voltage nanosecond pulse discharges is studied using one-dimensional particle-in-cell numerical simulations. The comparison between the various mechanisms of pre-ionization, i.e., by runaway electrons, x-rays, and ultraviolet radiation, is presented. It is shown that runaway electrons produce a much higher number of electron-ion pairs than those generated by x-rays, which accompany the process of runaway electron generation. Also, results of simulations showed that among photo-ionization mechanisms the most significant gas pre-ionization is caused by x-rays generated in the process of impact ionization of the K-shell of nitrogen atoms.

Levko, D.; Gurovich, V. Tz.; Krasik, Ya. E.

2012-01-01T23:59:59.000Z

353

Three-Dimensional Studies of the Warm Ionized Medium in the Milky Way using WHAM  

E-Print Network (OSTI)

The Wisconsin H-Alpha Mapper (WHAM) is a high throughput Fabry-Perot facility developed specifically to detect and explore the warm, ionized component of the interstellar medium at high spectral resolution. It began operating at Kitt Peak, Arizona in 1997 and has recently completed the WHAM Northern Sky Survey (WHAM-NSS), providing the first global view of the distribution and kinematics of the warm, diffuse H II in the Milky Way. This H-alpha survey reveals a complex spatial and kinematic structure in the warm ionized medium and provides a foundation for studies of the temperature and ionization state of the gas, the spectrum and strength of the ionizing radiation, and its relationship to other components of the interstellar medium and sources of ionization and heating within the Galactic disk and halo. More information about WHAM and the Survey can be found at http://www.astro.wisc.edu/wham/.

R. J. Reynolds; L. M. Haffner; G. J. Madsen

2002-01-23T23:59:59.000Z

354

Three-Dimensional Studies of the Warm Ionized Medium in the Milky Way using WHAM  

E-Print Network (OSTI)

The Wisconsin H-Alpha Mapper (WHAM) is a high throughput Fabry-Perot facility developed specifically to detect and explore the warm, ionized component of the interstellar medium at high spectral resolution. It began operating at Kitt Peak, Arizona in 1997 and has recently completed the WHAM Northern Sky Survey (WHAM-NSS), providing the first global view of the distribution and kinematics of the warm, diffuse H II in the Milky Way. This H-alpha survey reveals a complex spatial and kinematic structure in the warm ionized medium and provides a foundation for studies of the temperature and ionization state of the gas, the spectrum and strength of the ionizing radiation, and its relationship to other components of the interstellar medium and sources of ionization and heating within the Galactic disk and halo. More information about WHAM and the Survey can be found at http://www.astro.wisc.edu/wham/.

Reynolds, R J; Madsen, G J

2002-01-01T23:59:59.000Z

355

METHOD FOR MEASURING RADIATION  

DOE Patents (OSTI)

A method for measuring an unknown integrated quantity of radiation with a condenser ionization chamber is described. The chamber is initially charged to a predetermined voltage by a voltage source. The chamber is then removed from the source and exposed to an unknown quantity of radiation for a period of time. The quantity of radiation to which the chamber was exposed is then measured by detecting the magnitude of the pulse of current necessary to recharge the chamber of its initial value through a suitable impedance. The current pulse is amplified and measured directly by a suitable pulse height analyzing system. (AEC)

Roesch, W.C.; McCall, R.C.

1961-11-21T23:59:59.000Z

356

radiation.cdr  

Office of Legacy Management (LM)

Radiation-It's a Fact of Life Radiation-It's a Fact of Life It has been with us since the beginning of time. Everyone who has ever walked on this planet has been exposed to radiation. For the most part, nature is the largest source of exposure. It's in the air we breathe, the ground we walk on, and even the food we eat. The radiation we receive from all natural and some man-made sources is called "background radiation." The millirem (mrem) is a unit used for measuring radiation received by a person. The total average background for radiation received by people living in the United States is 360 millirem per year (mrem/yr), of which 300 mrem/yr is from natural sources, and 60 mrem/yr is man-made. Cosmic Radiation from the sun and stars Internal Radiation from naturally radioactive

357

Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures  

SciTech Connect

OAK - B135 This project final report summarizes modeling research conducted in the U.S. Department of Energy (DOE), Low Dose Radiation Research Program at the Lovelace Respiratory Research Institute from October 1998 through June 2003. The modeling research described involves critically evaluating the validity of the linear nonthreshold (LNT) risk model as it relates to stochastic effects induced in cells by low doses of ionizing radiation and genotoxic chemicals. The LNT model plays a central role in low-dose risk assessment for humans. With the LNT model, any radiation (or genotoxic chemical) exposure is assumed to increase one¡¯s risk of cancer. Based on the LNT model, others have predicted tens of thousands of cancer deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Our research has focused on developing biologically based models that explain the shape of dose-response curves for low-dose radiation and genotoxic chemical-induced stochastic effects in cells. Understanding the shape of the dose-response curve for radiation and genotoxic chemical-induced stochastic effects in cells helps to better understand the shape of the dose-response curve for cancer induction in humans. We have used a modeling approach that facilitated model revisions over time, allowing for timely incorporation of new knowledge gained related to the biological basis for low-dose-induced stochastic effects in cells. Both deleterious (e.g., genomic instability, mutations, and neoplastic transformation) and protective (e.g., DNA repair and apoptosis) effects have been included in our modeling. Our most advanced model, NEOTRANS2, involves differing levels of genomic instability. Persistent genomic instability is presumed to be associated with nonspecific, nonlethal mutations and to increase both the risk for neoplastic transformation and for cancer occurrence. Our research results, based on applications of NEOTRANS2, indicate that nonlinear threshold-type, dose-response relationships for excess stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected after exposure to low linear energy transfer (LET) gamma rays or gamma rays in combination with high-LET alpha radiation. Similar thresholds are expected for low-dose-rate low-LET beta irradiation. We attribute the thresholds to low-dose, low-LET radiation induced protection against spontaneous mutations and neoplastic transformations. The protection is presumed mainly to involve selective elimination of problematic cells via apoptosis. Low-dose, low-LET radiation is presumed to trigger wide-area cell signaling, which in turn leads to problematic bystander cells (e.g., mutants, neoplastically transformed cells) selectively undergoing apoptosis. Thus, this protective bystander effect leads to selective elimination of problematic cells (a tissue cleansing process in vivo). However, this protective bystander effects is a different process from low-dose stimulation of the immune system. Low-dose, low-LET radiation stimulation of the immune system may explain why thresholds for inducing excess cancer appear much larger (possibly more than 100-fold larger) than thresholds for inducing excess mutations and neoplastic transformations, when the dose rate is low. For ionizing radiation, the current risk assessment paradigm is such that the relative risk (RR) is always ¡Ý 1, no matter how small the dose. Our research results indicate that for low-dose or low-dose-rate, low-LET irradiation, RR < 1 may be more the rule than the exception. Directly tied to the current RR paradigm are the billion-dollar cleanup costs for radionuclide-contaminated DOE sites. Our research results suggest that continued use of the current RR paradigm for which RR ¡Ý 1 could cause more harm than benefit to society (e.g., by spreading unwarranted fear about phantom excess risks associated with low-dose low-LET radiation). Such phantom risks also may arise from risk assessments conducted for com

Scott, Bobby, R., Ph.D.

2003-06-27T23:59:59.000Z

358

Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low Dose, Low Dose Rate Exposures  

Science Conference Proceedings (OSTI)

OAK - B135 This project final report summarizes modeling research conducted in the U.S. Department of Energy (DOE), Low Dose Radiation Research Program at the Lovelace Respiratory Research Institute from October 1998 through June 2003. The modeling research described involves critically evaluating the validity of the linear nonthreshold (LNT) risk model as it relates to stochastic effects induced in cells by low doses of ionizing radiation and genotoxic chemicals. The LNT model plays a central role in low-dose risk assessment for humans. With the LNT model, any radiation (or genotoxic chemical) exposure is assumed to increase one¡¯s risk of cancer. Based on the LNT model, others have predicted tens of thousands of cancer deaths related to environmental exposure to radioactive material from nuclear accidents (e.g., Chernobyl) and fallout from nuclear weapons testing. Our research has focused on developing biologically based models that explain the shape of dose-response curves for low-dose radiation and genotoxic chemical-induced stochastic effects in cells. Understanding the shape of the dose-response curve for radiation and genotoxic chemical-induced stochastic effects in cells helps to better understand the shape of the dose-response curve for cancer induction in humans. We have used a modeling approach that facilitated model revisions over time, allowing for timely incorporation of new knowledge gained related to the biological basis for low-dose-induced stochastic effects in cells. Both deleterious (e.g., genomic instability, mutations, and neoplastic transformation) and protective (e.g., DNA repair and apoptosis) effects have been included in our modeling. Our most advanced model, NEOTRANS2, involves differing levels of genomic instability. Persistent genomic instability is presumed to be associated with nonspecific, nonlethal mutations and to increase both the risk for neoplastic transformation and for cancer occurrence. Our research results, based on applications of NEOTRANS2, indicate that nonlinear threshold-type, dose-response relationships for excess stochastic effects (problematic nonlethal mutations, neoplastic transformation) should be expected after exposure to low linear energy transfer (LET) gamma rays or gamma rays in combination with high-LET alpha radiation. Similar thresholds are expected for low-dose-rate low-LET beta irradiation. We attribute the thresholds to low-dose, low-LET radiation induced protection against spontaneous mutations and neoplastic transformations. The protection is presumed mainly to involve selective elimination of problematic cells via apoptosis. Low-dose, low-LET radiation is presumed to trigger wide-area cell signaling, which in turn leads to problematic bystander cells (e.g., mutants, neoplastically transformed cells) selectively undergoing apoptosis. Thus, this protective bystander effect leads to selective elimination of problematic cells (a tissue cleansing process in vivo). However, this protective bystander effects is a different process from low-dose stimulation of the immune system. Low-dose, low-LET radiation stimulation of the immune system may explain why thresholds for inducing excess cancer appear much larger (possibly more than 100-fold larger) than thresholds for inducing excess mutations and neoplastic transformations, when the dose rate is low. For ionizing radiation, the current risk assessment paradigm is such that the relative risk (RR) is always ¡Ý 1, no matter how small the dose. Our research results indicate that for low-dose or low-dose-rate, low-LET irradiation, RR fear about phantom excess risks associated with low-dose low-LET radiation). Such phantom risks also may arise from risk assessments conducted for com

Scott, Bobby, R., Ph.D.

2003-06-27T23:59:59.000Z

359

Effects of atomic radiation  

SciTech Connect

This book focuses on the lifelong effects of atomic radiation exposure in language understandable by the concerned layperson or the specialist in another field. The base of knowledge used is the work of the Atomic Bomb Casualty Commission and its successor since 1975 the Radiation Effects Research Foundation. Within the range of Chronic effects on human health the book provides a thorough review, although effects of nonionizing radiation, effects on structures, effects on other living species, and acute effects are not discussed.

Schull, W.J.

1995-12-31T23:59:59.000Z

360

RADIATION DOSIMETER  

DOE Patents (OSTI)

An improvement was made in the determination of amounts of ionizing radiation, particularly low-energy beta particles of less than 1000 rad total dose by means of fluid-phase dosimeter employing a stabilized-- sensitized ferrous-ferric colorimetric system in a sulphuric acid medium. The improvement in the dosimeter consists of adding to the ferrous-ferric system in concentrations of 10/sub -2/ to 10/sup -4/M an organic compound having one or more carboxylic or equivalent groups, such compounds being capable of chelating or complexing the iron ions in the solution. Suitable sensitizing and stabilizing agents are benzoic, phthalic, salicylic, malonic, lactic, maleic, oxalic, citric, succinic, phenolic tartaric, acetic, and adipic acid, as well as other compounds which are added to the solution alone or in certain combinations. As in conventional fluid-phase dosimeters, the absorbed dosage is correlated with a corresponding change in optical density at particular wavelengths of the solution.

Balkwell, W.R. Jr.; Adams, G.D. Jr.

1960-05-10T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Life-span effects of ionizing radiation in the beagle dog: A summary account of four decades of research funded by the US Department of Energy and its predecessor agencies  

Science Conference Proceedings (OSTI)

Nearly 40 years ago, the US Atomic Energy Commission made a far- reaching commitment to the support of life-span radiation-effects studies in a relatively long-lived animal, the beagle dog. Something in the range of 200 million dollars has already been spent on a group of closely related experiments, many of which are only now coming to fruition. Responsible fiscal management of these studies, directed toward securing an optimum return from past investments, and toward creative planning of future directions, requires a comprehensive view of this total effort. This report is designed to provide that comprehensive view. This is primarily intended as a research management document. Evaluation and interpretation are tasks for those directly involved in conducting these experiments. The limited objective of the present document is to describe what has been done, to give some of the background for why it was done, to describe results already realized and applications that have been made of these results -- all in a manner designed to display the total effort rather than piecemeal details. While proposing no specific answers to the questions ''Where do we go from here.''it is hoped that the document will provide a basis for approaching that question in an informed manner. The maintenance of a continuity of scientific understanding and direction in these experiments, which often continue beyond the initiating investigators' working life, is no small part of the problem involved in conducting these experiments.

Thompson, R.C.

1989-01-01T23:59:59.000Z

362

Investigating the Effects of Radiation on Phosphonium-Based Ionic Liquids.  

E-Print Network (OSTI)

??This thesis presents work on the understanding of the effects of ionizing radiation on phosphonium-based ionic liquids (ILs). The capability of ILs to dissolve a… (more)

Howett, Susan

2013-01-01T23:59:59.000Z

363

Low Dose Radiation Research Program: Image Gallery  

NLE Websites -- All DOE Office Websites (Extended Search)

Image Gallery Image Gallery These are images, photographs, and charts presented or developed for Low Dose Radiation Research Investigators’ Meetings. They may be used for presentations or reports. To save, right click on the picture, then choose "Save picture as." U.S. annual per-capita effective radiation dose from various sources for 1980. various sources 1980 Enlarge Image. U.S. annual per-capita effective radiation dose from various sources for 2006. various sources 2006 Enlarge Image. U.S. annual per-capita effective radiation dose from man-made sources in the United States for 2006. man-made 2006 Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience (Rem) Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience

364

Low Dose Radiation Research Program: Bruce E. Lehnert  

NLE Websites -- All DOE Office Websites (Extended Search)

E. Lehnert E. Lehnert Los Alamos National Laboratory Past Project Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment. Technical Abstracts 2002 Workshop: Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Lehnert, B.E., Cary, R., Gadbois, D. and Gupta G. 2001 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. 1999 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. Publications Lehnert, B.E., Radiation bystander effects. U.S.Department of Energy Research News (March 6 issue) Goldberg, Z. and Lehnert, B.E. (2002). Radiation-induced effects in

365

Pulse mode readout techniques for use with non-gridded industrial ionization chambers  

SciTech Connect

Highly sensitive readout technique for precision long-term radiation measurements has been developed and tested in the Radiation Control Department at Jefferson Lab. The new electronics design is used to retrieve ionization data in a pulse mode. The dedicated data acquisition system works with M=Audio Audiophile 192 High-Definition 24-bit/192 kHz audio cards, taking data in continuous waveform recording mode. The on-line data processing algorithms extract signals of the ionization events from the data flow and measure the ionization value for each event. Two different ion chambers are evaluated. The first is a Reuter-Stokes Argon-filled (at 25 atm) High Pressure Ionization Chamber (HPIC), commonly used as a detector part in many GE Reuter-Stokes instruments of the RSS series. The second is a VacuTec Model 70181, 5 atm Xenon-filled ionization chamber. Results for both chambers indicate that the techniques allow using industrial ICs for high sensitivity and precision long-term radiation measurements, while at the same time providing information about spectral characteristics of the radiation fields.

Popov, Vladimir E. [JLAB; Degtiarenko, Pavel V. [JLAB

2011-10-01T23:59:59.000Z

366

Low Dose Radiation Program: Links - Agencies with Radiation Regulatory  

NLE Websites -- All DOE Office Websites (Extended Search)

Agencies with Radiation Regulatory Concerns and Involvement Agencies with Radiation Regulatory Concerns and Involvement Biological Effects of Low Level Exposures (BELLE) Canadian Nuclear Safety Commission Center for Risk Excellence Health Protection Agency The Health Risks of Extraterrestrial Environments International Commission on Radiation Units and Measurements, Inc. International Commission on Radiological Protection (ICRP) International Radiation Protection Association (IRPA) NASA Space Radiation Program National Academy of Sciences (NAS) Nuclear and Radiation Studies Board National Aeronautics and Space Administration (NASA) NASA OBRR Task Book Publication National Council on Radiation Protection (NCRP) National Institute of Environmental Health Sciences (NIEHS) National Toxicology Program (NTP) Occupational Safety and Health Administration (OSHA)

367

Carbon nanotube-based field ionization vacuum  

E-Print Network (OSTI)

We report the development of a novel micropump architecture that uses arrays of isolated vertical carbon nanotubes (CNT) to field ionize gas particles. The ionized gas molecules are accelerated to and implanted into a ...

Jang, Daniel, M. Eng. Massachusetts Institute of Technology

2012-01-01T23:59:59.000Z

368

MUCOOL: Ionization Cooling R&D  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory MUCOOL Muon Ionization Cooling R&D Welcome to the muon ionization cooling experimental R&D page. The MuCool collaboration has been formed to pursue the development of a...

369

Packet personal radiation monitor  

DOE Patents (OSTI)

A personal radiation monitor of the chirper type is provided for detecting ionizing radiation. A battery powered high voltage power supply is used to generate and apply a high voltage bias to a G-M tube radiation sensor. The high voltage is monitored by a low-loss sensing network which generates a feedback signal to control the high voltage power supply such that the high voltage bias is recharged to +500 VDC when the current pulses of the sensor, generated by the detection of ionizing radiation events, discharges the high voltage bias to +450 VDC. During the high voltage recharge period an audio transducer is activated to produce an audible "chirp". The rate of the "chirps" is controlled by the rate at which the high voltage bias is recharged, which is proportional to the radiation field intensity to which the sensor is exposed. The chirp rate sensitivity is set to be approximately 1.5 (chirps/min/MR/hr.). The G-M tube sensor is used in a current sensing mode so that the device does not paralyze in a high radiation field.

Phelps, James E. (Knoxville, TN)

1989-01-01T23:59:59.000Z

370

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity  

NLE Websites -- All DOE Office Websites (Extended Search)

Cataract and Genetic Determinants of Radiosensitivity Cataract and Genetic Determinants of Radiosensitivity Kleiman, N.J. 1 , Smilenov, L.B. 2 , Brenner, D.J. 2 and Hall, E.J. 2 1 Department of Environmental Health Sciences, Mailman School of Public Health & 2 The Center for Radiological Research, College of Physicians & Surgeons, Columbia University, New York 10032 The lens of the eye is one of the most radiosensitive tissues in the body. Ocular ionizing radiation exposure results in characteristic, dose related, progressive lens changes leading to cataract formation. While initial, early stages of such opacification may not cause visual disability, the severity of such changes progressively increases with dose until vision is impaired and cataract extraction surgery may be required. The

371

Molecular Mechanisms of Low Dose Radiation Mediated Hormesis in C. elegans  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanisms of Low Dose Radiation Mediated Hormesis in C. Mechanisms of Low Dose Radiation Mediated Hormesis in C. elegans Anders Olsen, Maithili C. Vantipalli, Arnold Kahn, Judith Campisi and Gordon J. Lithgow. Buck Institute for Age Research, 8001 Redwood Boulevard, Novato CA 94945 Brief exposure to a mild stress causes induction of stress gene expression leading to enhanced stress responses, improved maintenance and repair and in some cases lifespan increase. This phenomenon is termed hormesis and has been observed in several species. For example, we previously demonstrated that short periods of mild heat stress in early life increase both mean and maximum lifespan of the soil nematode C. elegans. Similar hormetic responses have been described for many other stressors. Here we present data showing that treatment of the nematode with low-doses of ionizing

372

Low Dose Radiation Research Program: Comparisons of IR and ROS for  

NLE Websites -- All DOE Office Websites (Extended Search)

Comparisons of IR and ROS for Induction of Damage to Cells Comparisons of IR and ROS for Induction of Damage to Cells Kathryn D. Held1, Yvonne L. McCarey1, Laurence Tartier1, Elena V. Rusyn1, Giuseppe Schettino2, Melvyn Folkard2, Kevin M. Prise2, and Barry D. Michael2 1Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114; 2Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, HA6 2JR, UK Accurate evaluation of the risks associated with exposure to low doses of ionizing radiation (IR) is a major challenge for environmental sciences. Studies on the mechanisms of the actions of low doses of IR are needed to help understand possible risks. IR exerts its effects on cells through production of reactive oxidizing species (ROS) such as ·OH, H2O2 and

373

Low Dose Radiation Research Program: Low-Dose Dose-Response of  

NLE Websites -- All DOE Office Websites (Extended Search)

Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Dose Rate g-Radiation. Authors: Louise Enns,1 Michael Weinfeld,1 Albert Murtha,1 and Kenneth Bogen2 Institutions: 1Cross Cancer Institute and 2Lawrence Livermore National Laboratory. Clinical and environmental exposure to ionizing radiation rarely exceeds 200 cGy. To examine cell proliferation at early times (up to 5 days) post-irradiation, we are utilizing an assay in which single cells encapsulated within ~30- to 70-µm-diameter agarose gel microdrops (GMDs) are exposed and cultured for 4 days at 37°C, then analyzed by flow cytometry (FC). Clonogenic proliferation is measured as the fraction of occupied GMDs containing multicellular microcolonies after 4 days in culture. This assay was applied to human A549 lung cells exposed to gamma

374

Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in  

NLE Websites -- All DOE Office Websites (Extended Search)

Induced DNA Damage Signaling and Repair Responses in Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System Yanrong Su, Jarah Meador and Adayabalam S. Balajee Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West, 168th Street, New York, NY 10032. Exposure to ionizing radiation (IR) inflicts a wide variety of lesions in the genomic DNA. Among them, DNA double strand break (DSB) is considered to be the critical lesion for most of the deleterious radiation effects including carcinogenesis. Much of our knowledge on induction and repair kinetics of DSB has come from studies in two dimensional cell culture systems. However, the damage signaling and repair responses to DSB in tissue microenvironment are largely unknown. Knowledge of tissue responses to

375

Radiation Machines and Radioactive Materials (Iowa)  

Energy.gov (U.S. Department of Energy (DOE))

These chapters describe general provisions and regulatory requirements; registration, licensure, and transportation of radioactive materials; and exposure standards for radiation protection.

376

Low Dose Radiation Research Program: Aloke Chatterjee  

NLE Websites -- All DOE Office Websites (Extended Search)

Chatterjee, A. and Holley, W.R. 1999 Workshop: Biological Effects of Low-Dose and Low-Dose-Rate Radiation Exposures: An Integrated Theoretical and Experimental Approach....

377

Low Dose Radiation Research Program: Mohan Natarajan  

NLE Websites -- All DOE Office Websites (Extended Search)

of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Funded Project Real-Time Molecular Study of Bystander Effect Using...

378

ORISE Resources: Population Monitoring in Radiation Emergencies  

NLE Websites -- All DOE Office Websites (Extended Search)

into the body Removal of external or internal contamination (decontamination) Radiation dose received and the resulting health risk from the exposure Long-term health...

379

Low Dose Radiation Research Program Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

for medical exposures. Environmental and Molecular Mutagenesis 53(4): 247259 Lynn Hlatky ( 2012) Double-Strand Break Motions Shift Radiation Risk Notions?. PNAS...

380

Method and Apparatus for Measuring Radiation Quantities  

DOE Patents (OSTI)

This patent application describes a compact dosimeter for measuring X-ray and gamma radiation by the use of solutions which undergo a visible color change upon exposure to a predetermined quantity of radiation.

Roberts, N.O.

1950-07-31T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Enhanced radiation resistant fiber optics  

DOE Patents (OSTI)

A process for producing an optical fiber having enhanced radiation resitance is provided, the process including maintaining an optical fiber within a hydrogen-containing atmosphere for sufficient time to yield a hydrogen-permeated optical fiber having an elevated internal hydrogen concentration, and irradiating the hydrogen-permeated optical fiber at a time while the optical fiber has an elevated internal hydrogen concentration with a source of ionizing radiation. The radiation source is typically a cobalt-60 source and the fiber is pre-irradiated with a dose level up to about 1000 kilorads of radiation.

Lyons, P.B.; Looney, L.D.

1992-12-31T23:59:59.000Z

382

Study of the response of low pressure ionization chambers  

E-Print Network (OSTI)

The Beam Loss Monitoring System (BLM) of the Large Hadron Collider (LHC) is based on parallel plate Ionization Chambers (IC) with active volume 1.5l and a nitrogen filling gas at 0.1 bar overpressure. At the largest loss locations, the ICs generate signals large enough to saturate the read-out electronics. A reduction of the active volume and filling pressure in the ICs would decrease the amount of charge collected in the electrodes, and so provide a higher saturation limit using the same electronics. This makes Little Ionization Chambers (LIC) with both reduced pressure and small active volume a good candidate for these high radiation areas. In this contribution we present measurements performed with several LIC monitors with reduced active volume and various filling pressures. These detectors were tested under various conditions with different beam setups, with standard LHC ICs used for calibration purposes

Nebot Del Busto, E; Effinger, E; Grishin, V; Herranz Alvarez, J

2012-01-01T23:59:59.000Z

383

Microwave remote sensing of ionized air.  

SciTech Connect

We present observations of microwave scattering from ambient room air ionized with a negative ion generator. The frequency dependence of the radar cross section of ionized air was measured from 26.5 to 40 GHz (Ka-band) in a bistatic mode with an Agilent PNA-X series (model N5245A) vector network analyzer. A detailed calibration scheme is provided to minimize the effect of the stray background field and system frequency response on the target reflection. The feasibility of detecting the microwave reflection from ionized air portends many potential applications such as remote sensing of atmospheric ionization and remote detection of radioactive ionization of air.

Liao, S.; Gopalsami, N.; Heifetz, A.; Elmer, T.; Fiflis, P.; Koehl, E. R.; Chien, H. T.; Raptis, A. C. (Nuclear Engineering Division)

2011-07-01T23:59:59.000Z

384

Revised analyses of decommissioning for the reference boiling water reactor power station. Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure - appendices. Final report  

SciTech Connect

The NRC staff is in need of decommissioning bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to update the needed bases documentation. This report presents the results of a review and reevaluation of the PNL 1980 decommissioning study of the Washington Public Power Supply System`s Washington Nuclear Plant Two (WNP-2) located at Richland, Washington, including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5-7 year period during which time the spent fuel is stored in the spent fuel pool prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not presently part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clear structures on the site and to restore the site to a {open_quotes}green field{close_quotes} condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low-level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities. Sensitivity of the total license termination cost to the disposal costs at different low-level radioactive waste disposal sites, to different depths of contaminated concrete surface removal within the facilities, and to different transport distances is also examined.

Smith, R.I.; Bierschbach, M.C.; Konzek, G.J.; McDuffie, P.N.

1996-07-01T23:59:59.000Z

385

Revised analyses of decommissioning for the reference boiling water reactor power station. Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure - main report. Final report  

SciTech Connect

The NRC staff is in need of updated bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to update the needed bases documentation. This report presents the results of a review and reevaluation of the PNL 1980 decommissioning study of the Washington Public Power Supply System`s Washington Nuclear Plant Two (WNP-2), which is a boiling water reactor (BWR), located at Richland, Washington, including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5-7 year period during which time the spent fuel is stored in the spent fuel pool prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clean structures on the site and to restore the site to a {open_quotes}green field{close_quotes} condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low- level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities. Sensitivity of the total license termination cost to the disposal costs at different low-level radioactive waste disposal sites, to different depths of contaminated concrete surface removal within the facilities, and to different transport distances is also examined.

Smith, R.I.; Bierschbach, M.C.; Konzek, G.J.; McDuffie, P.N.

1996-07-01T23:59:59.000Z

386

Revised analyses of decommissioning for the reference pressurized Water Reactor Power Station. Volume 2, Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure: Appendices, Final report  

SciTech Connect

With the issuance of the final Decommissioning Rule (July 27, 1998), owners and operators of licensed nuclear power plants are required to prepare, and submit to the US Nuclear Regulatory Commission (NRC) for review, decommissioning plans and cost estimates. The NRC staff is in need of bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to provide some of the needed bases documentation. This report contains the results of a review and reevaluation of the 1978 PNL decommissioning study of the Trojan nuclear power plant (NUREG/CR-0130), including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the nuclear power plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5--7 year period during which time the spent fuel is stored in the spent fuel pool, prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not presently part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clean structures on the site and to restore the site to a ``green field`` condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low-level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities.

Konzek, G.J.; Smith, R.I.; Bierschbach, M.C.; McDuffie, P.N.

1995-11-01T23:59:59.000Z

387

Revised analyses of decommissioning for the reference pressurized Water Reactor Power Station. Effects of current regulatory and other considerations on the financial assurance requirements of the decommissioning rule and on estimates of occupational radiation exposure, Volume 1, Final report  

Science Conference Proceedings (OSTI)

With the issuance of the final Decommissioning Rule (July 27, 1988), owners and operators of licensed nuclear power plants are required to prepare, and submit to the US Nuclear Regulatory Commission (NRC) for review, decommissioning plans and cost estimates. The NRC staff is in need of bases documentation that will assist them in assessing the adequacy of the licensee submittals, from the viewpoint of both the planned actions, including occupational radiation exposure, and the probable costs. The purpose of this reevaluation study is to provide some of the needed bases documentation. This report contains the results of a review and reevaluation of the {prime}978 PNL decommissioning study of the Trojan nuclear power plant (NUREG/CR-0130), including all identifiable factors and cost assumptions which contribute significantly to the total cost of decommissioning the nuclear power plant for the DECON, SAFSTOR, and ENTOMB decommissioning alternatives. These alternatives now include an initial 5--7 year period during which time the spent fuel is stored in the spent fuel pool, prior to beginning major disassembly or extended safe storage of the plant. Included for information (but not presently part of the license termination cost) is an estimate of the cost to demolish the decontaminated and clean structures on the site and to restore the site to a ``green field`` condition. This report also includes consideration of the NRC requirement that decontamination and decommissioning activities leading to termination of the nuclear license be completed within 60 years of final reactor shutdown, consideration of packaging and disposal requirements for materials whose radionuclide concentrations exceed the limits for Class C low-level waste (i.e., Greater-Than-Class C), and reflects 1993 costs for labor, materials, transport, and disposal activities.

Konzek, G.J.; Smith, R.I.; Bierschbach, M.C.; McDuffie, P.N. [Pacific Northwest Lab., Richland, WA (United States)

1995-11-01T23:59:59.000Z

388

Exposure chamber  

DOE Patents (OSTI)

A chamber for exposing animals, plants, or materials to air containing gases or aerosols is so constructed that catch pans for animal excrement, for example, serve to aid the uniform distribution of air throughout the chamber instead of constituting obstacles as has been the case in prior animal exposure chambers. The chamber comprises the usual imperforate top, bottom and side walls. Within the chamber, cages and their associated pans are arranged in two columns. The pans are spaced horizontally from the walls of the chamber in all directions. Corresponding pans of the two columns are also spaced horizontally from each other. Preferably the pans of one column are also spaced vertically from corresponding pans of the other column. Air is introduced into the top of the chamber and withdrawn from the bottom. The general flow of air is therefore vertical. The effect of the horizontal pans is based on the fact that a gas flowing past the edge of a flat plate that is perpendicular to the flow forms a wave on the upstream side of the plate. Air flows downwardly between the chamber walls and the outer edges of the pan. It also flows downwardly between the inner edges of the pans of the two columns. It has been found that when the air carries aerosol particles, these particles are substantially uniformly distributed throughout the chamber.

Moss, Owen R. (Kennewick, WA)

1980-01-01T23:59:59.000Z

389

SURFACE LAYER ACCRETION IN CONVENTIONAL AND TRANSITIONAL DISKS DRIVEN BY FAR-ULTRAVIOLET IONIZATION  

Science Conference Proceedings (OSTI)

Whether protoplanetary disks accrete at observationally significant rates by the magnetorotational instability (MRI) depends on how well ionized they are. Disk surface layers ionized by stellar X-rays are susceptible to charge neutralization by small condensates, ranging from {approx}0.01 {mu}m sized grains to angstrom-sized polycyclic aromatic hydrocarbons (PAHs). Ion densities in X-ray-irradiated surfaces are so low that ambipolar diffusion weakens the MRI. Here we show that ionization by stellar far-ultraviolet (FUV) radiation enables full-blown MRI turbulence in disk surface layers. Far-UV ionization of atomic carbon and sulfur produces a plasma so dense that it is immune to ion recombination on grains and PAHs. The FUV-ionized layer, of thickness 0.01-0.1 g cm{sup -2}, behaves in the ideal magnetohydrodynamic limit and can accrete at observationally significant rates at radii {approx}> 1-10 AU. Surface layer accretion driven by FUV ionization can reproduce the trend of increasing accretion rate with increasing hole size seen in transitional disks. At radii {approx}<1-10 AU, FUV-ionized surface layers cannot sustain the accretion rates generated at larger distance, and unless turbulent mixing of plasma can thicken the MRI-active layer, an additional means of transport is needed. In the case of transitional disks, it could be provided by planets.

Perez-Becker, Daniel [Department of Physics, University of California, Berkeley, CA 94720 (United States); Chiang, Eugene [Departments of Astronomy and Earth and Planetary Science, University of California, Berkeley, CA 94720 (United States)

2011-07-01T23:59:59.000Z

390

Packet personal radiation monitor  

DOE Patents (OSTI)

A personal radiation monitor of the chirper type is provided for detecting ionizing radiation. A battery powered high voltage power supply is used to generate and apply a high voltage bias to a G-M tube radiation sensor. The high voltage is monitored by a low-loss sensing network which generates a feedback signal to control the high voltage power supply such that the high voltage bias is recharged to +500 VDC when the current pulses of the sensor, generated by the detection of ionizing radiatonevents, discharges the high voltage bias to +450 VDC. During the high voltage recharge period an audio transducer is activated to produce an audible ''chirp''. The rate of the ''chirps'' is controlled by the rate at which the high voltage bias is recharged, which is proportional to the radiation field intensity to which the sensor is exposed. The chirp rate sensitivity is set to be approximately 1.5 (chirps/min/MR/hr.). The G-M tube sensor is used in a current sensing mode so that the device does not paralyze in a high radiation field. 2 figs.

Phelps, J.E.

1988-03-31T23:59:59.000Z

391

Modeling early galaxies using radiation hydrodynamics  

Science Conference Proceedings (OSTI)

This simulation uses a flux-limited diffusion solver to explore the radiation hydrodynamics of early galaxies, in particular, the ionizing radiation created by Population III stars. At the time of this rendering, the simulation has evolved to a redshift ... Keywords: astrophysics, modeling, visualization

Joseph A. Insley; Rick Wagner; Robert Harkness; Daniel R. Reynolds; Michael L. Norman; Mark Hereld; Eric C. Olson; Michael E. Papka; Venkatram Vishwanath

2011-11-01T23:59:59.000Z

392

STORAGE RING CROSS-SECTION MEASUREMENTS FOR ELECTRON IMPACT SINGLE AND DOUBLE IONIZATION OF Fe{sup 9+} AND SINGLE IONIZATION OF Fe{sup 10+}  

SciTech Connect

We have measured electron impact ionization from the ground state of Fe{sup 9+} and Fe{sup 10+} over the relative electron-ion collision energy ranges 200-1900 eV and 250-1800 eV, respectively. The ions were confined in an ion storage ring long enough for essentially all metastable levels to radiatively relax to the ground state. For single ionization, we find a number of discrepancies between the existing theoretical cross sections and our results. The calculations appear to neglect some excitation-autoionization (EA) channels, particularly from n = 3 to n' excitations, which are important near threshold, and those from n = 2 {yields} 3 excitations, which contribute at about 650 eV. Conversely, at higher energies the calculations appear to overestimate the importance of EA channels due to excitation into levels where n {>=} 4. The resulting experimental rate coefficients agree with the most recent theory for Fe{sup 9+} to within 16% and for Fe{sup 10+} to within 19% at temperatures where these ions are predicted to form in collisional ionization equilibrium. We have also measured double ionization of Fe{sup 9+} forming Fe{sup 11+} in the energy range 450-3000 eV and found that although there is an appreciable cross section for direct double ionization, the dominant mechanism appears to be through direct ionization of an inner shell electron producing an excited state that subsequently stabilizes through autoionization.

Hahn, M.; Novotny, O.; Savin, D. W. [Columbia Astrophysics Laboratory, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Becker, A.; Grieser, M.; Krantz, C.; Wolf, A. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany); Lestinsky, M.; Repnow, R. [GSI Helmholtzzentrum fuer Schwerionenforschung, Planckstr. 1, D-64291 Darmstadt (Germany); Mueller, A.; Schippers, S.; Spruck, K. [Institut fuer Atom- und Molekuelphysik, Justus-Liebig-Universitaet Giessen, Leihgesterner Weg 217, D-35392 Giessen (Germany)

2012-11-20T23:59:59.000Z

393

Amorphous silicon radiation detectors  

DOE Patents (OSTI)

Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification.

Street, Robert A. (Palo Alto, CA); Perez-Mendez, Victor (Berkeley, CA); Kaplan, Selig N. (El Cerrito, CA)

1992-01-01T23:59:59.000Z

394

Amorphous silicon radiation detectors  

DOE Patents (OSTI)

Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification. 13 figs.

Street, R.A.; Perez-Mendez, V.; Kaplan, S.N.

1992-11-17T23:59:59.000Z

395

Review of medical findings in a Marshallese population twenty-six years after accidental exposure to radioactive fallout  

SciTech Connect

In March 1954, radioactive debris from a thermonuclear weapon test at Bikini Atoll deviated from predicted trajectories and contaminated several atolls in the northern Marshall Islands. As a result, 239 native inhabitants of these islands along with 28 American servicemen and 23 Japanese fishermen received variably severe exposures to diverse ionizing radiations. Fallout material consisted largely of mixed fission products with small amounts of neutron-induced radionuclides and minimal amounts of fissionable elements, producing a complex spectrum of electromagnetic and particulate radiation. Individuals were exposed to deeply penetrating, whole-body gamma irradiation, to internal radiation emitters assimilated either by inhalation or by ingestion of contaminated water and food, and to direct radiation from material accumulating on body surfaces. That accident initiated a cascade of events, medical, social and political, which continue in varying forms to this day. Most of these have been discussed in the open medical literature and in periodic reports issued by the medical team headquartered at Brookhaven National Laboratory. This report attempts to summarize some of the principal findings of medical significnce that have been observed during the subsequent 26 years with particular emphasis on the last six years.

Conard, R.A.; Paglia, D.E.; Larsen, P.R.

1980-01-01T23:59:59.000Z

396

Highly ionized atoms in tokamak discharges  

DOE Green Energy (OSTI)

Tokamak discharges are characterized by electron densities usually approximately 0.3 to 1.0 x 10/sup 14/ cm/sup -3/ and temperatures from a few hundred eV to several keV. In addition to the working gas (H or He), the plasma normally contains some light impurities (approximately 10/sup 12/ cm/sup -3/ O or C) that are completely stripped except at the outer periphery, and heavier elements from the vacuum wall and current-aperture limiter (Fe, Cr, Ni, W, Mo and others, approximately 10/sup 10/-10/sup 11/ cm/sup -3/) that remain partly stripped, hence relatively strongly radiating, throughout the discharge. Other elements, especially noble gases, may be deliberately added for diagnostic purposes. Resonance lines of Fe and Ar in the beryllium and lithium sequences, of Fe, Kr, and Mo in the magnesium and sodium sequences, and of Mo and Xe in the zinc and copper sequences have been used for rough determination of plasma composition. Since crucial plasma characteristics such as temperature and confinement time are sensitively affected by the local composition, it is essential to improve the available atomic data necessary for more accurate analysis: wavelengths, transition probabilities, excitation, ionization and recombination rates, especially for the heavier elements.

Hinnov, E.

1976-05-01T23:59:59.000Z

397

Sample Desorption/Ionization From Mesoporous Silica  

NLE Websites -- All DOE Office Websites (Extended Search)

Sample Desorption/Ionization From Mesoporous Silica Sample Desorption/Ionization From Mesoporous Silica Sample Desorption/Ionization From Mesoporous Silica Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Available for thumbnail of Feynman Center (505) 665-9090 Email Sample Desorption/Ionization From Mesoporous Silica Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin

398

Exposure Reduction Through Optimized Planning and Scheduling  

Science Conference Proceedings (OSTI)

The industry is challenged with increasing material inspections and complex maintenance work in areas with high radiation fields. Compounding this problem is the drive to reduce worker exposure. Efficient job planning and monitoring of worker exposure becomes more important in light of these challenges. An essential component of the ALARA program is centered on accurate and detailed work control. Drawing on industry experience, best practices, and the experience of the EPRI ALARA assessment team, EPRI de...

2005-12-14T23:59:59.000Z

399

Low dose ionizing radiation (IR) signaling regulation in vivo...  

NLE Websites -- All DOE Office Websites (Extended Search)

studies from our lab indicated that human cells exposed to low doses of IR caused growth stimulation, speeding cells up in their cell cycle division (i.e., checkpoint regulation),...

400

NIST Ionizing Radiat. Div. - 2005-2007: Strategic Focus 2  

Science Conference Proceedings (OSTI)

... in the understanding of theories of evolution of ... smaller quantities of special nuclear materials than ... of a detector for photons with energies above 15 ...

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Ionizing Radiation Div. 1995-1996 - Technical Highlights  

Science Conference Proceedings (OSTI)

... Experiments have already been done involving researchers from the University of Missouri-Columbia, Exxon, the Hahn-Meitner Institute (Berlin ...

402

CELLULAR RESPONSES AT LOW DOSES OF IONIZING RADIATION  

NLE Websites -- All DOE Office Websites (Extended Search)

and tissue levels including mutation induction and carcinogenesis. Furthermore, irradiation of the cytoplasm can initiate damage to the nucleus, and irradiated single cells...

403

Recollections on Sixty Years of NBS Ionizing Radiation ...  

Science Conference Proceedings (OSTI)

... Pregnant Women (1977). 55 Protection of the Thyroid Gland in the Event of Releases of Radioiodine (1977). Volume 111 ...

2006-12-11T23:59:59.000Z

404

IONIZING RADIATION RISKS TO SATELLITE POWER SYSTEMS (SPS) WORKERS  

E-Print Network (OSTI)

g/cm for tne storm cellar to be used during solar particlea storm cellar—is needed for space workers during a solar

Lyman, J.T.

2010-01-01T23:59:59.000Z

405

NIST Ionizing Radiation Safety Committee Initial Report of ...  

Science Conference Proceedings (OSTI)

... not perform a formal characterization analysis of ... powdered plutonium source contained only by a ... sources present in the inventory and approved in ...

2010-05-03T23:59:59.000Z

406

IONIZING RADIATION RISKS TO SATELLITE POWER SYSTEMS (SPS) WORKERS  

E-Print Network (OSTI)

belt intensity caused by geomagnetic substorms may result into the large amount of geomagnetic shielding available inL, denotes roughly a geomagnetic field line. The value gives

Lyman, J.T.

2010-01-01T23:59:59.000Z

407

NIST Ionizing Radiat. Div. - 2002: Strategic Focus 2  

Science Conference Proceedings (OSTI)

... at the NIST National Center for Neutron Research (NCNR) nuclear reactor. ... Spent fuel from nuclear reactors, weapons-grade plutonium, and certain ...

408

NIST Ionizing Radiat. Div. - 2005-2007: Strategic Focus 3  

Science Conference Proceedings (OSTI)

... NIST has established a satellite facility at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, to promote measurement accuracy for ...

409

NIST Ionizing Radiation Safety Committee Initial Report of ...  

Science Conference Proceedings (OSTI)

... to benefits, and the beneficial utilization of atomic and nuclear ... early market research; 23 ... into the storage cabinet, then charges a battery and leaves ...

2010-05-03T23:59:59.000Z

410

IONIZING RADIATION RISKS TO SATELLITE POWER SYSTEMS (SPS) WORKERS  

E-Print Network (OSTI)

to develop long-term, baseload, electrical energy sourcesthe feasibility of generating baseload electrical power with

Lyman, J.T.

2010-01-01T23:59:59.000Z

411

NIST Ionizing Radiat. Div. - 2005-2007: Strategic Focus 1  

Science Conference Proceedings (OSTI)

... to develop and provide neutron standards and measurements needed for worker protection, nuclear power, homeland security, and fundamental ...

412

NIST Ionizing Radiat. Div. - 2002: Strategic Focus 1  

Science Conference Proceedings (OSTI)

... Two new CdZnTe detectors were tested, and their ability to detect gamma-ray emitting sources was compared with existing High-Purity ...

413

Detection of Ionizing Radiation Using Graphene Field Effect Transistors  

E-Print Network (OSTI)

electrode, while the other electrode is the graphene layer. Applying a gate voltage, VG, field lines) of graphite, which has unique electronic properties [1]. Graphene has a high carrier mobility, about 10 times, and a layer of graphene on top (Fig. 2). The electric field is created by applying the gate voltage from

Chen, Yong P.

414

The effect of microhydration on ionization energies of thymine  

Science Conference Proceedings (OSTI)

A combined theoretical and experimental study of the effect of microhydration on ionization energies (IEs) of thymine is presented. The experimental IEs are derived from photoionization efficiency curves recorded using tunable synchrotron VUV radiation. The onsets of the PIE curves are 8.85+-0.05, 8.60+-0.05, 8.55+-0.05, and 8.40+-0.05 eV for thymine, thymine mono-, di-, and tri-hydrates, respectively. The computed (EOM-IP-CCSD/cc-pVTZ) AIEs are 8.90, 8.51, 8.52, and 8.35 eV for thymine and the lowest isomers of thymine mono-, di-, and tri-hydrates. Due to large structural relaxation, the Franck-Condon factors for the 0water molecule reduces the first vertical IE by 0.10-0.15 eV. The adiabatic IE decreases even more (up to 0.4 eV). The magnitude of the effect varies for different ionized states and for different isomers. For the ionized states that are localized on thymine the dominant contribution to the IE reduction is the electrostatic interaction between the delocalized positive charge on thymine and the dipole moment of the water molecule.

Khistyev, Kirill; Bravaya, Ksenia B.; Kamarchik, Eugene; Kostko, Oleg; Ahmed, Musahid; Krylov, Anna I.

2011-01-03T23:59:59.000Z

415

The effect of microhydration on ionization energies of thymine  

SciTech Connect

A combined theoretical and experimental study of the effect of microhydration on ionization energies (IEs) of thymine is presented. The experimental IEs are derived from photoionization efficiency curves recorded using tunable synchrotron VUV radiation. The onsets of the PIE curves are 8.85+-0.05, 8.60+-0.05, 8.55+-0.05, and 8.40+-0.05 eV for thymine, thymine mono-, di-, and tri-hydrates, respectively. The computed (EOM-IP-CCSD/cc-pVTZ) AIEs are 8.90, 8.51, 8.52, and 8.35 eV for thymine and the lowest isomers of thymine mono-, di-, and tri-hydrates. Due to large structural relaxation, the Franck-Condon factors for the 0<-- 0 transitions are very small shifting the apparent PIE onsets to higher energies. Microsolvation strongly affects IEs of thymine -- addition of each water molecule reduces the first vertical IE by 0.10-0.15 eV. The adiabatic IE decreases even more (up to 0.4 eV). The magnitude of the effect varies for different ionized states and for different isomers. For the ionized states that are localized on thymine the dominant contribution to the IE reduction is the electrostatic interaction between the delocalized positive charge on thymine and the dipole moment of the water molecule.

Khistyev, Kirill; Bravaya, Ksenia B.; Kamarchik, Eugene; Kostko, Oleg; Ahmed, Musahid; Krylov, Anna I.

2011-01-03T23:59:59.000Z

416

High-resolution ionization detector and array of such detectors  

DOE Patents (OSTI)

A high-resolution ionization detector and an array of such detectors are described which utilize a reference pattern of conductive or semiconductive material to form interaction, pervious and measurement regions in an ionization substrate of, for example, CdZnTe material. The ionization detector is a room temperature semiconductor radiation detector. Various geometries of such a detector and an array of such detectors produce room temperature operated gamma ray spectrometers with relatively high resolution. For example, a 1 cm.sup.3 detector is capable of measuring .sup.137 Cs 662 keV gamma rays with room temperature energy resolution approaching 2% at FWHM. Two major types of such detectors include a parallel strip semiconductor Frisch grid detector and the geometrically weighted trapezoid prism semiconductor Frisch grid detector. The geometrically weighted detector records room temperature (24.degree. C.) energy resolutions of 2.68% FWHM for .sup.137 Cs 662 keV gamma rays and 2.45% FWHM for .sup.60 Co 1.332 MeV gamma rays. The detectors perform well without any electronic pulse rejection, correction or compensation techniques. The devices operate at room temperature with simple commercially available NIM bin electronics and do not require special preamplifiers or cooling stages for good spectroscopic results.

McGregor, Douglas S. (Ypsilanti, MI); Rojeski, Ronald A. (Pleasanton, CA)

2001-01-16T23:59:59.000Z

417

Ionization Energies, Electron Affinities and Electronegativies ... - TMS  

Science Conference Proceedings (OSTI)

Jun 28, 2007 ... Periodic table of the elements containing ionization energies, electron affinities, and electronegativities. CITATION: : R.E. Dickerson, H.B. Gray ...

418

Hall Magnetohydrodynamics of weakly-ionized plasma  

E-Print Network (OSTI)

We show that the Hall scale in a weakly ionized plasma depends on the fractional ionization of the medium and, Hall MHD description becomes important whenever the ion-neutral collision frequency is comparable to the ion-gyration frequency, or, the ion-neutral collisional mean free path is smaller than the ion gyro-radius. Wave properties of a weakly-ionized plasma also depends on the fractional ionization and plasma Hall parameters, and whistler mode is the most dominant mode in such a medium. Thus Hall MHD description will be important in astrophysical disks, dark molecular clouds, neutron star crusts, and, solar and planetary atmosphere.

B. P. Pandey; Mark Wardle

2006-08-01T23:59:59.000Z

419

Health effects models for nuclear power plant accident consequence analysis. Modification of models resulting from addition of effects of exposure to alpha-emitting radionuclides: Revision 1, Part 2, Scientific bases for health effects models, Addendum 2  

SciTech Connect

The Nuclear Regulatory Commission (NRC) has sponsored several studies to identify and quantify, through the use of models, the potential health effects of accidental releases of radionuclides from nuclear power plants. The Reactor Safety Study provided the basis for most of the earlier estimates related to these health effects. Subsequent efforts by NRC-supported groups resulted in improved health effects models that were published in the report entitled {open_quotes}Health Effects Models for Nuclear Power Plant Consequence Analysis{close_quotes}, NUREG/CR-4214, 1985 and revised further in the 1989 report NUREG/CR-4214, Rev. 1, Part 2. The health effects models presented in the 1989 NUREG/CR-4214 report were developed for exposure to low-linear energy transfer (LET) (beta and gamma) radiation based on the best scientific information available at that time. Since the 1989 report was published, two addenda to that report have been prepared to (1) incorporate other scientific information related to low-LET health effects models and (2) extend the models to consider the possible health consequences of the addition of alpha-emitting radionuclides to the exposure source term. The first addendum report, entitled {open_quotes}Health Effects Models for Nuclear Power Plant Accident Consequence Analysis, Modifications of Models Resulting from Recent Reports on Health Effects of Ionizing Radiation, Low LET Radiation, Part 2: Scientific Bases for Health Effects Models,{close_quotes} was published in 1991 as NUREG/CR-4214, Rev. 1, Part 2, Addendum 1. This second addendum addresses the possibility that some fraction of the accident source term from an operating nuclear power plant comprises alpha-emitting radionuclides. Consideration of chronic high-LET exposure from alpha radiation as well as acute and chronic exposure to low-LET beta and gamma radiations is a reasonable extension of the health effects model.

Abrahamson, S. [Wisconsin Univ., Madison, WI (United States); Bender, M.A. [Brookhaven National Lab., Upton, NY (United States); Boecker, B.B.; Scott, B.R. [Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.; Gilbert, E.S. [Pacific Northwest Lab., Richland, WA (United States)

1993-05-01T23:59:59.000Z

420

Hematogical lesions as a function of dosage of long-term radiation  

Science Conference Proceedings (OSTI)

The quantitative patterns of damage to the blood system in the course of prolonged exposure to the ionizing radiation inherent in space were studied as well as the time characteristics of development of lesions in different blast elements. An effort was made to determine the minimal volume of hematological tests during long-term exposure to radiation to assess the general state of the blood system, on the basis of comparison of dynamics of changes in bone marrow and peripheral blood. Experiments were conducted on 285 mongrel rats weighing 180 to 200 g. The animals were exposed to radiation at dose rates of 300, 100, and 50 R/day. They were exposed continuously for 22-23/day. Analysis of the findings revealed that the dynamics of decline in total number of bone marrow cells during the phase of primary depletion is governed by an exponential law. There was distinct demonstration of the effects of cumulative dose and dose rate. A typical finding in all cell populations of bone marrow was an initial exponential decline in number of cells.

Gorlov, V.G.; Neyman, O.V.

1982-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Low Dose Radiation Program: Links - Current Issues Involving...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Ionizing Radiation A-Bombs Atomicarchive.com Hiroshima Peace site History of the Atomic Bomb & The Manhattan Project The Atomic Testing Museum The Race to Build the Atomic...

422

Low Dose Radiation Research Program: Mechanistic Modeling of...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory Why This Project? Cells that are directly exposed to low doses of ionizing radiation may experience DNA damage. Cells which happen to be in the vicinity of the exposed...

423

Quantification of radiation induced crosslinking in a commercial, toughened silicone rubber, TR-55, by 1H MQ-NMR  

SciTech Connect

Radiation induced degradation in a commercial, filled silicone composite has been studied by SPME/GC-MS, DMA, DSC, swelling, and Multiple Quantum NMR. Analysis of volatile and semivolatile species indicates degradation via decomposition of the peroxide curing catalyst and radiation induced backbiting reactions. DMA, swelling, and spin-echo NMR analysis indicate a increase in crosslink density of near 100% upon exposure to a cumulative dose of 250 kGray. Analysis of the sol-fraction via Charlseby-Pinner analysis indicates a ratio of chain scission to crosslinking yields of 0.38, consistent with the dominance of the crosslinking observed by DMA, swelling and spin-echo NMR and the chain scissioning reactions observed by MS analysis. Multiple Quantum NMR has revealed a bimodal distribution of residual dipolar couplings near 1 krad/sec and 5 krad/sec in an approximately 90:10 ratio, consistent with bulk network chains and chains associated with the filler surface. Upon exposure to radiation, the mean {Omega}{sub d} for both domains and the width of both domains both increased. The MQ NMR analysis provided increase insight into the effects of ionizing radiation on the network structure of silicone polymers.

Maxwell, R; Chinn, S; Alviso, C; Harvey, C A; Giuliani, J; Wilson, T; Cohenour, R

2008-11-10T23:59:59.000Z

424

RADIATION DETECTING AND TELEMETERING SYSTEM  

DOE Patents (OSTI)

A system is presented for measuring ionizing radiation at several remote stations and transmitting the measured information by radio to a central station. At each remote station a signal proportioned to the counting rate is applied across an electrical condenser made of ferroelectric material. The voltage across the condenser will vary as a function of the incident radiation and the capacitance of the condenser will vary accordingly. This change in capacitance is used to change the frequency of a crystalcontrolled oscillator. The output of the oscillator is coupled to an antenna for transmitting a signal proportional to the incident radiation.

Richards, H.K.

1959-12-15T23:59:59.000Z

425

Intensity-resolved Above Threshold Ionization Yields of Atoms with Ultrashort Laser Pulses  

E-Print Network (OSTI)

The above threshold ionization (ATI) spectra provide a diversity of information about a laser-atom ionization process such as laser intensity, pulse duration, carrier envelope phase, and atomic energy level spacing. However, the spatial distribution of intensities inherent in all laser beams reduces the resolution of this information. This research focuses on recovering the intensity-resolved ATI spectra from experimental data using a deconvolution algorithm. Electron ionization yields of xenon were measured for a set of laser pulse intensities using a time of flight (TOF) setup. Horizontally polarized, unchirped, 50fs pulses were used in the ionization process. All laser parameters other than the radiation intensity were held constant over the set of intensity measurements. A deconvolution algorithm was developed based on the experimental parameters. Then the deconvolution algorithm was applied to the experimental data to obtain the intensity-resolved total yield probability and ATI spectra. Finally, an error analysis was performed to determine the stability and accuracy of the algorithm as well as the quality of the data. It was found that the algorithm produced greater contrast for peaks in the ATI spectra where atom specific resonant behavior is observed. Additionally, the total yield probability showed that double ionization may be observed in the ionization yield. The error analysis revealed that the algorithm was stable under the experimental conditions for a range of intensities.

Hart, Nathan Andrew

2011-08-01T23:59:59.000Z

426

Method for the depth corrected detection of ionizing events from a co-planar grids sensor  

DOE Patents (OSTI)

A method for the detection of ionizing events utilizing a co-planar grids sensor comprising a semiconductor substrate, cathode electrode, collecting grid and non-collecting grid. The semiconductor substrate is sensitive to ionizing radiation. A voltage less than 0 Volts is applied to the cathode electrode. A voltage greater than the voltage applied to the cathode is applied to the non-collecting grid. A voltage greater than the voltage applied to the non-collecting grid is applied to the collecting grid. The collecting grid and the non-collecting grid are summed and subtracted creating a sum and difference respectively. The difference and sum are divided creating a ratio. A gain coefficient factor for each depth (distance between the ionizing event and the collecting grid) is determined, whereby the difference between the collecting electrode and the non-collecting electrode multiplied by the corresponding gain coefficient is the depth corrected energy of an ionizing event. Therefore, the energy of each ionizing event is the difference between the collecting grid and the non-collecting grid multiplied by the corresponding gain coefficient. The depth of the ionizing event can also be determined from the ratio.

De Geronimo, Gianluigi (Syosset, NY); Bolotnikov, Aleksey E. (South Setauket, NY); Carini, Gabriella (Port Jefferson, NY)

2009-05-12T23:59:59.000Z

427

RADIATION EFFECTS ON EPOXY/CARBON FIBER COMPOSITE  

SciTech Connect

The Department of Energy Savannah River Site vitrifies nuclear waste incident to defense programs through its Defense Waste Processing Facility (DWPF). The piping in the DWPF seal pot jumper configuration must withstand the stresses during an unlikely but potential deflagration event, and maintain its safety function for a 20-year service life. Carbon fiber-reinforced epoxy composites (CFR) were proposed for protection and reinforcement of piping during such an event. The proposed CFR materials have been ASME-approved (Section XI, Code Case N-589-1) for post-construction maintenance and is DOT-compliant per 49CFR 192 and 195. The proposed carbon fiber/epoxy composite reinforcement system was originally developed for pipeline rehabilitation and post-construction maintenance in petrochemical, refineries, DOT applications and other industries. The effects of ionizing radiation on polymers and organic materials have been studied for many years. The majority of available data are based on traditional exposures to gamma irradiation at high dose rates ({approx}10,000 Gy/hr) allowing high total dose within reasonable test periods and general comparison of different materials exposed at such conditions. However, studies in recent years have shown that degradation of many polymers are sensitive to dose rate, with more severe degradation often observed at similar or even lower total doses when exposed to lower dose rates. This behavior has been primarily attributed to diffusion-limited oxidation which is minimized during very high dose rate exposures. Most test standards for accelerated aging and nuclear qualification of components acknowledge these limitations. The results of testing to determine the radiation resistance and microstructural effects of gamma irradiation exposure on a bisphenol-A based epoxy matrix composite reinforced with carbon fibers are presented. This work provides a foundation for a more extensive evaluation of dose rate effects on advanced epoxy reinforced composites.

Hoffman, E; Eric Skidmore, E

2008-12-12T23:59:59.000Z

428

Audible radiation monitor  

DOE Patents (OSTI)

This invention consists of a method and apparatus for monitoring ionizing radiation comprising radiation detectors in electrical connection with an isotopic analyzer and a device for producing chords to which each isotope is mapped so that the device produces a unique chord for each isotope. Preferably the chords are pleasing to the ear, except for chords representing unexpected isotopes, and are louder or softer depending on the level of radioactivity produced by each isotope, and musical instrument voices may be simulated in producing the chords as an aid to distinguishing similar-sounding chords. Because of the representation by chords, information regarding the level and composition of the radiation in an area can be conveyed to workers in that area more effectively and yet without distracting them.

Odell, D.M.C.

1992-12-31T23:59:59.000Z

429

Ionization tube simmer current circuit  

DOE Patents (OSTI)

A highly efficient flash lamp simmer current circuit utilizes a fifty percent duty cycle square wave pulse generator to pass a current over a current limiting inductor to a full wave rectifier. The DC output of the rectifier is then passed over a voltage smoothing capacitor through a reverse current blocking diode to a flash lamp tube to sustain ionization in the tube between discharges via a small simmer current. An alternate embodiment of the circuit combines the pulse generator and inductor in the form of an FET off line square wave generator with an impedance limited step up output transformer which is then applied to the full wave rectifier as before to yield a similar simmer current.

Steinkraus, Jr., Robert F. (Livermore, CA)

1994-01-01T23:59:59.000Z

430

Ionization tube simmer current circuit  

DOE Patents (OSTI)

A highly efficient flash lamp simmer current circuit utilizes a fifty percent duty cycle square wave pulse generator to pass a current over a current limiting inductor to a full wave rectifier. The DC output of the rectifier is then passed over a voltage smoothing capacitor through a reverse current blocking diode to a flash lamp tube to sustain ionization in the tube between discharges via a small simmer current. An alternate embodiment of the circuit combines the pulse generator and inductor in the form of an FET off line square wave generator with an impedance limited step up output transformer which is then applied to the full wave rectifier as before to yield a similar simmer current. 6 figures.

Steinkraus, R.F. Jr.

1994-12-13T23:59:59.000Z

431

Miniaturized radiation chirper  

SciTech Connect

The disclosure relates to a miniaturized radiation chirper for use with a small battery supplying on the order of 5 volts. A poor quality CdTe crystal which is not necessarily suitable for high resolution gamma ray spectroscopy is incorporated with appropriate electronics so that the chirper emits an audible noise at a rate that is proportional to radiation exposure level. The chirper is intended to serve as a personnel radiation warning device that utilizes new and novel electronics with a novel detector, a CdTe crystal. The resultant device is much smaller and has much longer battery life than existing chirpers.

Umbarger, C. John (Los Alamos, NM); Wolf, Michael A. (Los Alamos, NM)

1980-01-01T23:59:59.000Z

432

RADIATION SAFETY MANUAL  

E-Print Network (OSTI)

RADIATION SAFETY is the responsibility of all faculty, staff and students who are directly or indirectly involved in the use of radioisotopes or radiation-producing machines. In July 1963, the State of Texas granted The University of Texas at Austin a broad radioactive materials license for research, development and instruction. While this means a minimum of controls by the state, it requires that The University establish and pursue an effective Radiation Safety Program. The Radiation Safety Committee is responsible for The University's radiation control program outlined in this manual. The use of radiation in a university, where a large number of people may be unaware of their exposure to radiation hazards, makes strict adherence to procedures established by federal and state authorities of paramount importance for the protection of The University and the safety of its faculty, staff and students. It is the responsibility of all faculty, staff and students involved in radiation work to familiarize themselves thoroughly with The University's radiation control program and to comply with its requirements and all applicable federal and state regulations. I hope you will always keep in mind that radiation safety depends on a continuous awareness of potential hazards and on the acceptance

unknown authors

2005-01-01T23:59:59.000Z

433

Low-Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Bobby R. Scott, Ph.D. and Jennifer D. Di Palma Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE Albuquerque, NM 87108 USA Life on earth evolved in a low-level ionizing radiation environment comprised of terrestrial radiation and cosmic rays. Today we all reside in an ionizing radiation environment comprised of both natural background radiation and radiation from human activities (e.g., Chernobyl accident). An evolutionary benefit of the interaction of low-level, low linear-energy-transfer (LET) ionizing radiation with mammalian life forms on earth is adapted protection. Adapted protection involves low-dose/dose-rate, low-LET radiation induced high-fidelity DNA repair in cooperation with normal apoptosis (presumed p53

434

A 3D Monte Carlo Photoionization Code for Modeling Diffuse Ionized Gas  

E-Print Network (OSTI)

We have developed a three dimensional Monte Carlo photoionization code tailored for the study of Galactic H II regions and the percolation of ionizing photons in diffuse ionized gas. We describe the code, our calculation of photoionization, heating & cooling, and the approximations we have employed for the low density H II regions we wish to study. Our code gives results in agreement with the Lexington H II region benchmarks. We show an example of a 2D shadowed region and point out the very significant effect that diffuse radiation produced by recombinations of helium has on the temperature within the shadow.

Wood, K; Ercolano, B

2004-01-01T23:59:59.000Z

435

Low Dose Radiation Research Program: Earlier Events  

NLE Websites -- All DOE Office Websites (Extended Search)

Earlier Events Earlier Events 2000 | 2001 | 2002 | 2003 | 2004 April 2000 Ionizing Radiation Science and Protection in the 21st Century, NCRP, April 5-6, Arlington, VA. RADIATION RESEARCH 2000, Association for Radiation Research, April 10-12, Bristol, UK. Florida Chapter of the Health Physics Society Spring 2000 Meeting, Gainesville, FL, April 13-14. 47th Annual Meeting of the Radiation Research Society, April 29-May 3, Albuquerque, NM. May 2000 IRPA-10 International Congress 2000, May 14-19, Hiroshima, Japan. IRPA-10 Secretariat, c/o Japan Convention Services, Inc., Nippon Press Center Building, 2-2-1, Uchisaiwai-cho, Chiyoda-ku, Tokyo 100, Japan. Phone: 81-3-3508-1214. Fax: 81-3-3508-0820. irpa10@convention.jp. 4th International Non-Ionizing Radiation Workshop, May 22-25, Kyoto,

436

Los Alamos Lab: Radiation Protection: Annual Occupational Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Annual Occupational Radiation Dosimetry Report Print information on Annual Occupational Radiation Dosimetry Report (pdf). This webpage provides information to help you understand the dose quantities being reported to you on your Annual Occupational Radiation Dosimetry Report. If you would like general information about radiation exposure, please refer to www.radiationanswers.org. Title 10 Code of Federal Regulation Part 835, Occupational Radiation Protection (10 CFR 835), requires assessment, recording and reporting of radiation doses to individuals who are exposed to sources of radiation or radioactive contamination. This includes assessing external exposure from a variety of radiation types, such as, beta, photon, and neutron radiation. External exposures may be uniform over the whole body or occur in a non-uniform (i.e., limited body location) fashion. Internal doses occur when radioactive material is taken into the body through ingestion, inhalation, absorption or wounds. The requirements include assessing doses to the whole body, skin, lens of the eyes, extremities and various organs and tissues.

437

Chapter 15: Radiation Safety and Shielding 15-1 NSLS-II Conceptual Design Report  

E-Print Network (OSTI)

controls will only be employed as supplemental to control radiation exposure. An internal control level in the BNL Standards Based Management System. The maximum annual exposure to radiation workers and members 835.1001, measures will be taken to maintain radiation exposure as low as reasonably achievable (ALARA

Ohta, Shigemi

438

Population exposure from the fuel cycle: Review and future direction  

SciTech Connect

The legacy of radiation exposures confronting man arises from two historical sources of energy, the sun and radioactive decay. Contemporary man continues to be dependent on these two energy sources, which include the nuclear fuel cycle. Radiation exposures from all energy sources should be examined, with particular emphasis on the nuclear fuel cycle, incidents such as Chernobyl and Three Mile Island. In addition to risk estimation, concepts such as de minimis, life shortening as a measure of risk, and competing risks as projected into the future must be considered in placing radiation exposures in perspective. The utility of these concepts is in characterizing population exposures for decision makers in a manner that the public may judge acceptable. All these viewpoints are essential in the evaluation of population exposure from the nuclear fuel cycle.

Richmond, C.R.

1987-01-01T23:59:59.000Z

439

NIST Ground Levels and Ionization Energies for the Neutral ...  

Science Conference Proceedings (OSTI)

The ionization energies in the table are based on a recent survey of ... cited compilation gives the reference(s) for the original ionization-energy data. ...

2013-09-16T23:59:59.000Z

440

Geant4 applications in the heliospheric radiation environment  

E-Print Network (OSTI)

The high energy ionizing radiation environment in the solar system consists of three main sources: the radiation belts, galactic cosmic rays and solar energetic particles. Geant4 is a Monte Carlo radiation transport simulation toolkit, with applications in areas as high energy physics, nuclear physics, astrophysics or medical physics research. In this poster, Geant4 applications to model and study the effects of the heliospheric radiation environment are presented. Specific applications are being developed to study the effect of the radiation environment on detector components, to describe the response and to optimise the design of radiation monitors for future space missions and to predict the radiation environment in Mars surface, orbits and moons.

Pedro Brogueira; Patrícia Gonçalves; Ana Keating; Dalmiro Maia; Mário Pimenta; Bernardo Tomé

2007-09-11T23:59:59.000Z

Note: This page contains sample records for the topic "ionizing radiation exposure" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Low Dose Radiation Research Program: Genetic Factors Affecting  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Radiation. Authors: William F. Morgan, Pat Concannon & John H.J. Petrini The goal of this program is to test the hypothesis that mice heterozygous for the NBS1 gene are genetically susceptible to low doses of ionizing radiation. Patients with Nijmegen Breakage Syndrome (NBS) are radiation sensitive, because of defects in cellular responses to radiation induced genetic damage. It is unclear whether humans heterozygous for the mutations associated with NBS are radiation sensitive and results from cell culture experiments give conflicting results. In collaboration with John Petrini at the Memorial Sloan Kettering Cancer Center in New York City we developed a mouse model of this disorder and are directly testing the hypothesis

442

Approximations for radiative cooling and heating in the solar chromosphere  

E-Print Network (OSTI)

Context. The radiative energy balance in the solar chromosphere is dominated by strong spectral lines that are formed out of LTE. It is computationally prohibitive to solve the full equations of radiative transfer and statistical equilibrium in 3D time dependent MHD simulations. Aims. To find simple recipes to compute the radiative energy balance in the dominant lines under solar chromospheric conditions. Methods. We use detailed calculations in time-dependent and 2D MHD snapshots to derive empirical formulae for the radiative cooling and heating. Results. The radiative cooling in neutral hydrogen lines and the Lyman continuum, the H and K and intrared triplet lines of singly ionized calcium and the h and k lines of singly ionized magnesium can be written as a product of an optically thin emission (dependent on temperature), an escape probability (dependent on column mass) and an ionization fraction (dependent on temperature). In the cool pockets of the chromosphere the same transitions contribute to the heat...

Carlsson, Mats

2012-01-01T23:59:59.000Z

443

Charged-Particle Impact Ionization of Atoms  

Science Conference Proceedings (OSTI)

We have developed a hybrid method to treat charged-particle impact ionization of complex atoms and ions. The essential idea is to describe the interaction between a fast projectile and the target perturbatively, up to second order, while the initial bound state and the ejected-electron--residual-ion interaction can be handled via a convergent R-matrix with pseudo-states (close-coupling) expansion. Example results for ionization of the heavy noble gases (Ne-Xe) by positron and electron impact are presented. The general scheme for a distorted-wave treatment of ionization by heavy-particle impact is described.

Bartschat, Klaus; Guan Xiaoxu [Department of Physics and Astronomy, Drake University, Des Moines, IA 50311 (United States)

2008-08-08T23:59:59.000Z

444

An Assessment of Aquatic Radiation Pathways in Northern Ireland  

E-Print Network (OSTI)

.1 The fishing industry 11 3.2 Fishing areas 11 4. INTERNAL RADIATION EXPOSURE PATHWAYS 12 4.1 Fish 12 4. ANALYSIS OF DATA 19 7.1 Internal radiation exposure 19 7.1.1 Fish consumption 19 7.1.2 Crustacean and clams 14 4.3.4 Razor fish and squid 15 5. EXTERNAL RADIATION EXPOSURE PATHWAYS 15 5.1 Beach and coastal

445