Sample records for involving older drivers

  1. Projecting Fatalities in Crashes Involving Older Drivers, 2000–2025, CRADA No. ORNL98-0500 Final Report

    SciTech Connect (OSTI)

    Hu, Patricia S. [ORNL] [ORNL; Jones, Donald W. [ORNL] [ORNL; Reuscher, Timothy [Oak Ridge Institute for Science and Education] [Oak Ridge Institute for Science and Education; Schmoyer, Richard S. [ORNL] [ORNL; Truett, Lorena F. [ORNL] [ORNL

    2000-04-01T23:59:59.000Z

    At the turn of the century – the 20th century that is – the median age in the United States was under 30 years; America was 60% rural in nature; and there were only 36 highway fatalities all year. As we leave the 20th century behind, the route into the 21st century is very different. “Intelligent” cars speed down multi-lane “smart” highways in a nation that is 75% urban. According to the Federal Highway Administration’s Highway Statistics, there are 28,000 times more vehicles on the road in 2000 than there were in 1900, and these vehicles travel about 2.6 trillion miles each year. Annual fatalities resulting from highway crashes have also increased – by over 1100%. We see other changes as well. The face of America is changing. It is growing older. In 2025, persons 65 and over will make up 18.5% of the total population. The number of persons aged 85 and over is increasing more rapidly than any other age group. More importantly, the elderly are taking more trips, driving further, and continuing to drive much later in life. These conditions lead to concerns about traffic safety. Although the elderly are healthier and drive safer cars than they did just two decades ago, their frailty makes them more susceptible to injury than younger persons involved in traffic crashes of the same severity. In addition, visual, physical, and cognitive skills, all of which contribute to driving abilities, decrease with advancing age. The familiar “U”-shaped curve depicting the rate of fatalities per vehicle miles traveled, shows that the elderly experience a higher highway fatality rate than any other age group except teenagers. While the overall number of highway fatalities has decreased regularly since 1972, the number of fatalities of elderly travelers has continued to increase steadily. This increase is cause for concern for both the elderly driver and for other persons on the roads who migh tbe placed in danger through crashes involving elderly drivers.

  2. Alternative highway sign alphabet styles for older drivers

    E-Print Network [OSTI]

    Tan, Carol Hannah

    1991-01-01T23:59:59.000Z

    ALTERNATIVE HIGHWAY SIGN ALPHABET STYLES FOR OLDER DRIVERS A Thesis by Carol Hannah Tan Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May... (Member) Jame T. . Yao (Head of partment) May 1991 ABSTRACT Alternative Highway Sign Alphabet Styles for Older Drivers. (May 1991) Carol Hannah Tan, B. S. , Texas A8 M University Chair of Advisory Committee: Dr. Daniel B. Farnbro In the United...

  3. Assessment of older driver understanding of certain traffic control devices in Texas

    E-Print Network [OSTI]

    Hulett, Stephanie Renee

    2000-01-01T23:59:59.000Z

    The purpose of this research was to assess older Texas drivers on their understanding of nine traffic control devices and identify the devices that are misunderstood by people 65 years and older. Additionally, older driver education programs were...

  4. Projecting Fatalities in Crashes Involving Older Drivers, 20002025

    E-Print Network [OSTI]

    of Transportation under CRADA No. ORNL98-0500 Prepared by the OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee

  5. 9. Driver's Age 13. Driver's Date of Birth 14. Driver's Social Security Number 19. Driver's Telephone

    E-Print Network [OSTI]

    Gering, Jon C.

    of Accident (city, state; if on a highway, give number and nearest community) DRIVER INFORMATION OTHER VEHICLE OR PROPERTY Occupied Unoccupied 17. Driver's Age VEHICLE OPERATED BY UNIVERSITY EMPLOYEE Occupied Unoccupied 8. Driver's Name 16. Driver's Name TRUMAN STATE UNIVERSITY VEHICLE ACCIDENT REPORT NAME AND ADDRESS AREA

  6. Efficacy, national/international practices and motivational factors of lifelong driver education for the aging population

    E-Print Network [OSTI]

    Israels, Richard (Richard Steven)

    2006-01-01T23:59:59.000Z

    In a society facing a significant increase in its aging population, older driver education/training is emerging as a potential solution to help seniors drive more safely, thus maintaining their mobility and quality of life. ...

  7. Driver eye height measurement

    E-Print Network [OSTI]

    Abrahamson, Anthony Daniel

    1978-01-01T23:59:59.000Z

    DRIVER EYF HEIGHT MFASHRFMENT A Thesis by ANTHONY DANIEL ABRAHAMSON Submitted to the Graduate College of Texas A&M Hniversity in partial fulfillment oi the requirement for the degree of MASTER OF SCIENCE December 1978 Major Subje"t: Civil... Engineering DRIVER EYE HEIGHT MEASUREMENT A Thesis by ANTHONY DANIEL ABRAHAMSON Approved as to style and content by: I (C irman of Committee) (Member) (Memb er ) Head of Department) December 1978 ABSTRACT Driver. Eye Height Neasurement. (December...

  8. Vehicle Management Driver Safety Program

    E-Print Network [OSTI]

    Machel, Hans

    Vehicle Management and Driver Safety Program Manual Facilities & Operations / Finance & Administration Version 2 April 2012 #12;© 2012 University of Alberta. #12;The Vehicle Management and Driver of employment. Driver Acknowledgement I have received the University of Alberta, Vehicle Management and Driver

  9. Nutrition for Older Adults.

    E-Print Network [OSTI]

    Sweeten, Mary K.; Ryan-Crowe, V. Cass

    1982-01-01T23:59:59.000Z

    are common among older persons: An adequate diet, indudhg ample amounts of fruits and veg- etables, will hetp prevent them. Nutritional Anemia Older persons often suffer from nutritional anemia. This indicates a lack of iron, protein or certain vitamins... participate in planning menus and service, morale is higher. Dental Changes Adjust family food preparation to make foods easy to chew so an older person with denture problems can eat a well balanced diet. Meat and other protein foods may need...

  10. Approaches to enhance driver situational assessment aids

    E-Print Network [OSTI]

    Jones, Eric M. (Eric Michael)

    2007-01-01T23:59:59.000Z

    Collision warning systems encounter a fundamental trade-off between providing the driver more time in which to respond and alerting the driver unnecessarily. The probability that a driver successfully avoids a hazard ...

  11. Highway crash rates and age-related driver limitations: Literature review and evaluation of data bases

    SciTech Connect (OSTI)

    Hu, P.S. [Oak Ridge National Lab., TN (United States)] [Oak Ridge National Lab., TN (United States); Young, J.R. [Tennessee Univ., Knoxville, TN (United States)] [Tennessee Univ., Knoxville, TN (United States); Lu, An [Oak Ridge Associated Universities, Inc., TN (United States)] [Oak Ridge Associated Universities, Inc., TN (United States)

    1993-08-01T23:59:59.000Z

    American society is undergoing a major demographic transformation that is resulting in a larger proportion of older individuals in the population. Moreover, recent travel surveys show that an increasing number of older individuals are licensed to drive and that they drive more than their same age cohort a decade ago. However, they continue to take shorter trips than younger drivers and they avoid driving during congested hours. This recent demographic transformation in our society, the graying of America, coupled with the increasing mobility of the older population impose a serious highway safety issue that cannot be overlooked. Some of the major concerns are the identification of ``high-risk`` older drivers and the establishment of licensing guidelines and procedures that are based on conclusive scientific evidence. Oak Ridge National Laboratory`s (ORNL) objectives in this project can be characterized by the following tasks: Review and evaluate the 1980 American Association of Motor Vehicle Administrators (AAMVA) and National Highway Traffic Safety Administration (NHTSA) licensing guidelines. Determine whether the license restriction recommended in the 1980 AAMVA and NHTSA guidelines was based on scientific evidence or on judgement of medical advisors. Identify in the scientific literature any medical conditions which are found to be highly associated with highway crashes, and which are not mentioned in the 1980 guidelines. Summarize States` current licensing practices for drivers with age-related physical and mental limitations. Identify potential data sources to establish conclusive evidence on age-related functional impairments and highway crashes.

  12. UWB dual burst transmit driver

    DOE Patents [OSTI]

    Dallum, Gregory E. (Livermore, CA); Pratt, Garth C. (Discovery Bay, CA); Haugen, Peter C. (Livermore, CA); Zumstein, James M. (Livermore, CA); Vigars, Mark L. (Livermore, CA); Romero, Carlos E. (Livermore, CA)

    2012-04-17T23:59:59.000Z

    A dual burst transmitter for ultra-wideband (UWB) communication systems generates a pair of precisely spaced RF bursts from a single trigger event. An input trigger pulse produces two oscillator trigger pulses, an initial pulse and a delayed pulse, in a dual trigger generator. The two oscillator trigger pulses drive a gated RF burst (power output) oscillator. A bias driver circuit gates the RF output oscillator on and off and sets the RF burst packet width. The bias driver also level shifts the drive signal to the level that is required for the RF output device.

  13. JLAB Electron Driver Capabilities

    SciTech Connect (OSTI)

    Kazimi, Reza [Jefferson Lab, 12000 Jefferson Avenue, Newport News, VA 23606 (United States)

    2009-09-02T23:59:59.000Z

    Several schemes have been proposed for adding a positron beam option at the Continuous Electron Beam Facility (CEBAF) at Jefferson Laboratory (JLAB). They involve using a primary beam of electrons or gamma rays striking a target to produce a positron beam. At JLAB electron beams are produced and used in two different accelerators, CEBAF and the JLAB FEL (Free Electron Laser). Both have low emittance and energy spread. The CEBAF beam is polarized. The FEL beam is unpolarized but the injector can produce a higher current electron beam. In this paper we describe the characteristics of these beams and the parameters relevant for positron production.

  14. Visualization drivers for Geant4

    SciTech Connect (OSTI)

    Beretvas, Andy; /Fermilab

    2005-10-01T23:59:59.000Z

    This document is on Geant4 visualization tools (drivers), evaluating pros and cons of each option, including recommendations on which tools to support at Fermilab for different applications. Four visualization drivers are evaluated. They are OpenGL, HepRep, DAWN and VRML. They all have good features, OpenGL provides graphic output without an intermediate file. HepRep provides menus to assist the user. DAWN provides high quality plots and even for large files produces output quickly. VRML uses the smallest disk space for intermediate files. Large experiments at Fermilab will want to write their own display. They should proceed to make this display graphics independent. Medium experiment will probably want to use HepRep because of it's menu support. Smaller scale experiments will want to use OpenGL in the spirit of having immediate response, good quality output and keeping things simple.

  15. 4, 615650, 2007 Drivers of storage

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    BGD 4, 615­650, 2007 Drivers of storage water use in Scots pine H. Verbeeck et al. Title Page drivers of storage water use in Scots pine H. Verbeeck1 , K. Steppe2 , N. Nadezhdina3 , M. Op De Beeck1 Correspondence to: H. Verbeeck (hans.verbeeck@ua.ac.be) 615 #12;BGD 4, 615­650, 2007 Drivers of storage water use

  16. Selected Texas Driver Education Instructors’ Feelings About A Driver Education Cultural Awareness Survey

    E-Print Network [OSTI]

    Saint, Nina Jo

    2012-07-16T23:59:59.000Z

    This study examined what items driver education instructors felt should be included in a cultural awareness survey to assess instructors' preparedness to teach a culturally diverse student clientele. In addition, the study examined the ways driver...

  17. Drivers of Future Energy Demand

    Gasoline and Diesel Fuel Update (EIA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for On-Highway4,1,50022,3,,,,6,1,9,1,50022,3,,,,6,1,Decade Year-0E (2001)gasoline353/06) 2Yonthly Energy :and1. Total3.9Drivers

  18. P5 Science Drivers: Theory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible for RenewableSpeedingBiomass and BiofuelsOversight BoardP-GlycoproteiniiiScience Drivers:

  19. Software Support for Improved Driver Reliability

    E-Print Network [OSTI]

    Swift, Michael

    .6.23, 2007 esp.c, a serial port driver static int rs_write(struct tty_struct * tty, const unsigned char *buf

  20. Construction of a driver-vehicle model and identification of the driver model parameters

    E-Print Network [OSTI]

    Su, Jemeng

    1981-01-01T23:59:59.000Z

    CONSTRUCTION OF A DRIVER-VEHICLE MODEL AND IDENTIFICATION OF THE DRIVER MODEL PARAMETERS A Thesis by , JEMENG SU Submitted to the Graduate College of Texas A8M University in partial fulfillment of the requiremr nt for the degree of MASTER... OF SCIENCE December 1981 Major Subject: Mechanical Engineering CONSTRUCTION OF A DRIVER-VEHICLE MODEL AND IDENTIFICATION OF THE DRIVER MODEL PARAMETERS A Thesis by JEMENG SU Approved as to style and content by: (Chairman of Committe ) / I...

  1. Construction of a driver-vehicle model and identification of the driver model parameters 

    E-Print Network [OSTI]

    Su, Jemeng

    1981-01-01T23:59:59.000Z

    CONSTRUCTION OF A DRIVER-VEHICLE MODEL AND IDENTIFICATION OF THE DRIVER MODEL PARAMETERS A Thesis by , JEMENG SU Submitted to the Graduate College of Texas A8M University in partial fulfillment of the requiremr nt for the degree of MASTER... OF SCIENCE December 1981 Major Subject: Mechanical Engineering CONSTRUCTION OF A DRIVER-VEHICLE MODEL AND IDENTIFICATION OF THE DRIVER MODEL PARAMETERS A Thesis by JEMENG SU Approved as to style and content by: (Chairman of Committe ) / I...

  2. Driver comprehension of railroad-highway grade crossings

    E-Print Network [OSTI]

    Messick, Jennifer

    1995-01-01T23:59:59.000Z

    each year; however, collisions at grade crossings are still a major concern. In order to continue improving safety at grade crossings, driver comprehension and driver attitudes must be investigated. This research investigated driver comprehension...

  3. 9, 1443714473, 2012 Soil carbon drivers

    E-Print Network [OSTI]

    Ickert-Bond, Steffi

    BGD 9, 14437­14473, 2012 Soil carbon drivers and benchmarks in Earth system models K. E. O. Todd if available. Causes of variation in soil carbon predictions from CMIP5 Earth system models and comparison #12;BGD 9, 14437­14473, 2012 Soil carbon drivers and benchmarks in Earth system models K. E. O. Todd

  4. FFAG ACCELERATOR PROTON DRIVER FOR NEUTRINO FACTORY.

    SciTech Connect (OSTI)

    RUGGIERO, A.

    2005-06-21T23:59:59.000Z

    This paper is the summary of a conceptual study of a Proton Driver for Neutrino Factory based on the use of a Fixed-Field Alternating-Gradient (FFAG) Accelerator. The required proton energy range for an optimum neutrino production is 5 to 12 GeV. This can be accomplished with a group of three concentric rings each with 807 m circumference [1]. FFAG Accelerators [2] have the capability to accelerate charged particles over a large momentum range ({+-}30-50%) and the feature of constant bending and focusing fields. Particles can be accelerated very fast at the rate given by the accelerating field of RF cavities placed in proper locations between magnets. The performance of FFAG accelerators is to be placed between that of Super-Conducting Linear Accelerators (SCL), with which they share the fast acceleration rate, and Rapid-Cycling Synchrotrons (RCS), as they allow the beam to re-circulate over fewer revolutions. Brookhaven National Laboratory is involved in the study of feasibility of FFAG Accelerators to accelerate intense beams of protons in the GeV energy range for a variety of applications the most important of which is the Upgrade of the Alternating Gradient Synchrotron (AGS) with a new FFAG injector [3] accelerating from 400 MeV to 1.5 GeV. The ring would be housed in the AGS tunnel and has henceforth a circumference of 807 m.

  5. V-217: Microsoft Windows NAT Driver ICMP Packet Handling Denial...

    Broader source: Energy.gov (indexed) [DOE]

    A vulnerability was reported in the Windows NAT Driver PLATFORM: Windows Server 2012 ABSTRACT: This security update resolves a vulnerability in the Windows NAT Driver in Microsoft...

  6. Vehicle Technologies Office Merit Review 2015: Gate Driver Optimizatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Gate Driver Optimization for WBG Applications Vehicle Technologies Office Merit Review 2015: Gate Driver Optimization for WBG Applications Presentation given by Oak Ridge National...

  7. Brazil's Biofuels Scenario: What are the Main Drivers Which will...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Brazil's Biofuels Scenario: What are the Main Drivers Which will Shape Investments in the Long Term? Brazil's Biofuels Scenario: What are the Main Drivers Which will Shape...

  8. Parent Involvement

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10T23:59:59.000Z

    To be successful, a 4-H program must have parent involvement. Although 4-H leaders and Extension agents may interest young people in becoming members, they need the parents' goodwill and support to keep them interested, enthusiastic and active. Here...

  9. Project Title: Older People's View of

    E-Print Network [OSTI]

    Hickman, Mark

    /AGECONCERN/10/NP Age Concern Canterbury provides support for older people, many of whom face loneliness, lowProject Title: Older People's View of Community Support Bachelor of Arts Internship Company information, support and advocacy, to enable older people in Canterbury to have real choices". (http

  10. Drawing driver's attention to potentially dangerous objects

    E-Print Network [OSTI]

    Kurugöl, Orc?un

    2008-01-01T23:59:59.000Z

    Drivers often have difficulties noticing potentially dangerous objects due to weather or lighting conditions or when their field of view is restricted. This thesis presents a display method for potentially dangerous objects ...

  11. A Landscape of Driver Mutations in Melanoma

    E-Print Network [OSTI]

    Lander, Eric S.

    Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure. We developed a permutation-based ...

  12. Physics at a new Fermilab proton driver

    SciTech Connect (OSTI)

    Geer, Steve; /Fermilab

    2006-04-01T23:59:59.000Z

    In 2004, motivated by the recent exciting developments in neutrino physics, the Fermilab Long Range Planning Committee identified a new high intensity Proton Driver as an attractive option for the future. At the end of 2004 the APS ''Study on the Physics of Neutrinos'' concluded that the future US neutrino program should have, as one of its components, ''A proton driver in the megawatt class or above and neutrino superbeam with an appropriate very large detector capable of observing Cp violation and measuring the neutrino mass-squared differences and mixing parameters with high precision''. The presently proposed Fermilab Proton Driver is designed to accomplish these goals, and is based on, and would help develop, Linear Collider technology. In this paper the Proton Driver parameters are summarized, and the potential physics program is described.

  13. Carbon Price Drivers:Carbon Price Drivers:Carbon Price Drivers:Carbon Price Drivers: AAAAnnnn UpdatedUpdatedUpdatedUpdated Literature ReviewLiterature ReviewLiterature ReviewLiterature Review

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , such as unexpected fluctuations in energy demand, energy prices (e.g., oil, gas, coal) and weather conditions1 Carbon Price Drivers:Carbon Price Drivers:Carbon Price Drivers:Carbon Price Drivers: AAAAnnnn the factors that shape the price of carbon, where one European Union Allowance is equal to one ton of CO2

  14. Driver expectancy in locating automotive controls 

    E-Print Network [OSTI]

    Francis, Dawn Suzette

    1990-01-01T23:59:59.000Z

    DRIVER EXPECTANCY IN LOCATING AUTOMOTIVE CONTROLS A Thesis by DAWN SUZETTE FRANCIS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 1990... Major Subject: Industrial Engineering DRIVER EXPECTANCY IN LOCATING AUTOMOTIVE CONTROLS A Thesis by DAWN SUZETTE FRANCIS Approved as to style and content by: R. Dale Huchi son (Chair of Committee) Rodger . . ppa (Member) Waymon L ohnston (M er...

  15. Drivers of Commercial Building Operator Skills

    E-Print Network [OSTI]

    Domanski, J.

    2011-01-01T23:59:59.000Z

    0 Drivers of Commercial Building Operator Skills C&W OVERVIEW C&W SUSTAINABILITY STRATEGIES GROUP WHAT?S DRIVING THE NEED FOR TRAINING? NECESSARY SKILLS & KNOWLEDGE C&W DEVELOPMENT & TRAINING OPPORTUNITIES International Conference... from: ? Owners/investors 4 DRIVERS ? OWNER/INVESTOR DEMAND ?UN Global Compact / Accenture 2010 CEO survey: ?93% of CEOs believe sustainability is ?critical? ?96% believe should be integrated into core business/operations ?C&W 2011survey...

  16. Local Danger Warnings for Drivers: The Effect of Modality and Level of Assistance on Driver Reaction

    E-Print Network [OSTI]

    Theune, Mariët

    Local Danger Warnings for Drivers: The Effect of Modality and Level of Assistance on Driver¨ucken, Germany christian.mueller@dfki.de ABSTRACT Local danger warning is an important function of Advanced presentation) is particularly crucial to a successful danger avoidance. We present a user study investigating

  17. Detection of Driver Fatigue Caused by Sleep Deprivation

    E-Print Network [OSTI]

    Coughlin, Joseph F.

    This paper aims to provide reliable indications of driver drowsiness based on the characteristics of driver-vehicle interaction. A test bed was built under a simulated driving environment, and a total of 12 subjects ...

  18. Evaluation of teenage driver understanding of traffic control devices

    E-Print Network [OSTI]

    Ford, Garry Lee

    1999-01-01T23:59:59.000Z

    This research documents the evaluation of teenage graphics. drivers with regards to their understanding of 53 traffic control devices. A multiple choice survey was developed and administered to a group of teenage drivers between 15 and 18 years...

  19. Solar Supply Chain and Market Driver Analysis 

    E-Print Network [OSTI]

    Martinez, Nicholas 1990-

    2012-05-09T23:59:59.000Z

    This study aims to explore the evolution of the photovoltaic supply chain in the United States and the drivers which foster growth of the solar market. The study will gather knowledge on the growth of the solar market and roles of different firms...

  20. MOTOR VEHICLE USE PROGRAM DRIVER SAFETY TIPS

    E-Print Network [OSTI]

    MOTOR VEHICLE USE PROGRAM DRIVER SAFETY TIPS Observe Speed Limits and Traffic Laws ­ Allow - Employees who drive Institute or privately owned vehicles on Institute business must possess and carry person. Insurance - Employees who operate their privately owned vehicles on Institute business shall

  1. Driver expectancy in locating automotive controls

    E-Print Network [OSTI]

    Francis, Dawn Suzette

    1990-01-01T23:59:59.000Z

    Major Subject: Industrial Engineering DRIVER EXPECTANCY IN LOCATING AUTOMOTIVE CONTROLS A Thesis by DAWN SUZETTE FRANCIS Approved as to style and content by: R. Dale Huchi son (Chair of Committee) Rodger . . ppa (Member) Waymon L ohnston (M er... assessment of automotive industry practices in 1971 and concluded that only 50% of controls/displays on various models could be said to have a common location. Perel (1974) reviewed prior research and found that it would be difficult to pinpoint...

  2. After the Disaster: Considerations for Older Adults

    E-Print Network [OSTI]

    Crocker, Andrew

    2005-10-07T23:59:59.000Z

    When older adults must evacuate their homes, they may worry about receiving their Social Security payments, receiving Medicare benefits from new health care providers, and replacing medications left behind. This publication explains who to call...

  3. Improved gauge driver for the generalized harmonic Einstein system

    SciTech Connect (OSTI)

    Lindblom, Lee; Szilagyi, Bela [Theoretical Astrophysics 350-17, California Institute of Technology, Pasadena, California 91125 (United States)

    2009-10-15T23:59:59.000Z

    A new gauge driver is introduced for the generalized harmonic (GH) representation of Einstein's equation. This new driver allows a rather general class of gauge conditions to be implemented in a way that maintains the hyperbolicity of the combined evolution system. This driver is more stable and effective and, unlike previous drivers, allows stable evolutions using the dual-frame evolution technique. Appropriate boundary conditions for this new gauge driver are constructed, and a new boundary condition for the 'gauge' components of the spacetime metric in the GH Einstein system is introduced. The stability and effectiveness of this new gauge driver are demonstrated through numerical tests, which impose a new damped-wave gauge condition on the evolutions of single black-hole spacetimes.

  4. Regulatory Drivers | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberg and SondershausenRegulatory Drivers In July 7,

  5. Analyzing Fuel Saving Opportunities through Driver Feedback Mechanisms...

    Office of Environmental Management (EM)

    Fuel Saving Opportunities through Driver Feedback Mechanisms 2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer...

  6. analysis identifies driver: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    et al. 2010 Invasive sensors to monitor physiological signals EEG, ECG, pulse@utdallas.edu MSP - CRSS Long-Term Goal: Monitoring Driver Behavior 5 "%"&'(...

  7. aged drivers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    et al. 2010 Invasive sensors to monitor physiological signals EEG, ECG, pulse@utdallas.edu MSP - CRSS Long-Term Goal: Monitoring Driver Behavior 5 "%"&'(...

  8. CLAIMANT AUTO ACCIDENT REPORT For Completion by Driver

    E-Print Network [OSTI]

    Tullos, Desiree

    CLAIMANT AUTO ACCIDENT REPORT For Completion by Driver D E P A R T M E N T O F A D M I N I S T R Address City State Zip For what purpose was car being used at time of accident? Has damage been repaired signals did you give? Other Driver? Who investigated? Who Cited and Why? Describe Accident CONTINUE

  9. Ris Energy Report 5 Global drivers for transformation of energy systems 3 Global drivers for transformation of energy

    E-Print Network [OSTI]

    of greenhouse gases has brought a new political rationale for the development of more climate-friendly energy in the global energy market of rapidly-expanding national economies, notably China and India. TogetherRisø Energy Report 5 Global drivers for transformation of energy systems 3 Global drivers

  10. Nonlinear transmission line based electron beam driver

    SciTech Connect (OSTI)

    French, David M.; Hoff, Brad W.; Tang Wilkin; Heidger, Susan; Shiffler, Don [Directed Energy Directorate, Air Force Research Laboratory, Kirtland AFB, New Mexico 87117 (United States); Allen-Flowers, Jordan [Program in Applied Mathematics, University of Arizona, Tucson, Arizona 85721 (United States)

    2012-12-15T23:59:59.000Z

    Gated field emission cathodes can provide short electron pulses without the requirement of laser systems or cathode heating required by photoemission or thermionic cathodes. The large electric field requirement for field emission to take place can be achieved by using a high aspect ratio cathode with a large field enhancement factor which reduces the voltage requirement for emission. In this paper, a cathode gate driver based on the output pulse train from a nonlinear transmission line is experimentally demonstrated. The application of the pulse train to a tufted carbon fiber field emission cathode generates short electron pulses. The pulses are approximately 2 ns in duration with emission currents of several mA, and the train contains up to 6 pulses at a frequency of 100 MHz. Particle-in-cell simulation is used to predict the characteristic of the current pulse train generated from a single carbon fiber field emission cathode using the same technique.

  11. Design consistency and driver error as reflected by driver workload and accident rates

    E-Print Network [OSTI]

    Wooldridge, Mark Douglas

    1992-01-01T23:59:59.000Z

    primary directions, speed consistency and driver workload. Speed consistency consists of analyzing predicted speeds on a highway and striving to keep those speeds within a narrow range. Several major research studies have provided methodologies... participating in the Texas Department of Transportation's Masters in Civil Engineering (MSCE) program, and performed the research that formed the basis for this report under the auspices of the Texas Transportation Institute. The data used as a basis...

  12. Learning Dialogue Strategies from Older and Younger Simulated Users 

    E-Print Network [OSTI]

    Georgila, Kallirroi; Wolters, Maria; Moore, Johanna D.

    2010-01-01T23:59:59.000Z

    Older adults are a challenging user group because their behaviour can be highly variable. To the best of our knowledge, this is the first study where dialogue strategies are learned and evaluated with both simulated younger users and simulated older...

  13. Young and Older Adults’ Reading of Distracters

    E-Print Network [OSTI]

    Kemper, Susan; McDowd, Joan; Metcalf, Kim; Liu, Chiung-Ju

    2008-05-01T23:59:59.000Z

    . Psychology and Aging , 22, 84-94. Kemper, S., & McDowd, J. (2006). Eye movements of young and older adults while reading with distraction. Psychology and Aging, 21, 32-39. Kucera, H., & Francis, W.N. (1967). Computational Analysis of Present-Day American... English. Providence: Brown University Press. Lavie, N., (1995). Perceptual load as a necessary condition for selective attention. Journal of Experimental Psychology: Human Perception and Performance, 21, 451-468. Maylor, E. A., & Lavie, N. (1998...

  14. An Optimization Framework for Driver Feedback Systems

    SciTech Connect (OSTI)

    Malikopoulos, Andreas [ORNL; Aguilar, Juan P. [Georgia Institute of Technology

    2013-01-01T23:59:59.000Z

    Modern vehicles have sophisticated electronic control units that can control engine operation with discretion to balance fuel economy, emissions, and power. These control units are designed for specific driving conditions (e.g., different speed profiles for highway and city driving). However, individual driving styles are different and rarely match the specific driving conditions for which the units were designed. In the research reported here, we investigate driving-style factors that have a major impact on fuel economy and construct an optimization framework to optimize individual driving styles with respect to these driving factors. In this context, we construct a set of polynomial metamodels to reflect the responses produced in fuel economy by changing the driving factors. Then, we compare the optimized driving styles to the original driving styles and evaluate the effectiveness of the optimization framework. Finally, we use this proposed framework to develop a real-time feedback system, including visual instructions, to enable drivers to alter their driving styles in response to actual driving conditions to improve fuel efficiency.

  15. Threat assessment design for driver assistance system at intersections

    E-Print Network [OSTI]

    Aoude, Georges

    This paper considers the decision-making problem for a human-driven vehicle crossing a road intersection in the presence of other, potentially errant, drivers. Our approach relies on a novel threat assessment module, which ...

  16. active gate driver: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    chip for SiC FET-driver chip is intended to drive SiC power FETs in DC-DC converters in a hybrid electric vehicle Tolbert, Leon M. 7 Current Balancing Control for Parallel...

  17. A Retroreflective Sheeting Selection Technique for Nighttime Drivers' Needs

    E-Print Network [OSTI]

    Paulus, Susan C.

    2010-07-14T23:59:59.000Z

    In this thesis, the author developed a retroreflective sheeting selection technique for traffic signs. Previous research was used to determine the luminance needed by drivers (demand luminance). The author used roadways scenarios to determine...

  18. Visual Attention and Driver Performance at Horizontal Curves

    E-Print Network [OSTI]

    Brimley, Bradford K.

    2014-12-02T23:59:59.000Z

    Despite the frequency with which drivers encounter curves on highways, curves are regularly identified as locations that experience disproportionately high crash rates. Crash data suggest that inattention is one of the leading causes of crashes...

  19. ambulance drivers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: BGD 9, 14437-14473, 2012 Soil carbon drivers and benchmarks in Earth system models K. E. O. Todd if available. Causes of variation in soil carbon predictions from...

  20. Your Role as a Jefferson Lab Fleet Vehicle Driver | Jefferson...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Your Role as a Jefferson Lab Fleet Vehicle Driver Responsibility Number One - Safe Driving As a vehicle operator, it is up to you to drive safely and sensibly to avoid crashes. The...

  1. Science Drivers and Technical Challenges for Advanced Magnetic Resonance

    SciTech Connect (OSTI)

    Mueller, Karl T.; Pruski, Marek; Washton, Nancy M.; Lipton, Andrew S.

    2013-03-07T23:59:59.000Z

    This report recaps the "Science Drivers and Technical Challenges for Advanced Magnetic Resonance" workshop, held in late 2011. This exploratory workshop's goal was to discuss and address challenges for the next generation of magnetic resonance experimentation. During the workshop, participants from throughout the world outlined the science drivers and instrumentation demands for high-field dynamic nuclear polarization (DNP) and associated magnetic resonance techniques, discussed barriers to their advancement, and deliberated the path forward for significant and impactful advances in the field.

  2. Look-ahead Driver Feedback and Powertrain Management

    SciTech Connect (OSTI)

    Verma, Rajeev

    2014-12-31T23:59:59.000Z

    Commercial medium and heavy vehicles, though only a small portion of total vehicle population, play a significant role in energy consumption. In 2012, these vehicles accounted for about 5775.5 trillion btu of energy consumption and 408.8 million tons of CO2 emissions annually, which is a quarter of the total energy burden of highway transportation in the United States [1]. This number is expected to surpass passenger car fuel use within the next few decades. In the meantime, most commercial vehicle fleets are running at a very low profit margin. It is a wellknown fact that fuel economy can vary significantly between drivers, even when they operate the same vehicle on the same route. According to the US Environmental Protection Agency (EPA) and Natural Resource Canada (NRCan), there is up to 35% fuel economy difference between drivers within the same commercial fleet [2] [3], [4]. Similar results were obtained from a Field Operation Test conducted by Eaton Corporation [5]. During this test as much as 30% fuel economy difference was observed among pick-up-and-delivery drivers and 11% difference was observed among line-haul drivers. The driver variability can be attributed to the fact that different drivers react differently to driving conditions such as road grade, traffic, speed limits, etc. For instance, analysis of over 600k miles of naturalistic heavy duty truck driving data [5] indicates that an experienced driver anticipates a downhill and eases up on the throttle to save fuel while an inexperienced driver lacks this judgment.

  3. Driver tension responses generated by various levels of intersection illumination

    E-Print Network [OSTI]

    Franklin, Weldon Clifford

    1962-01-01T23:59:59.000Z

    DRIVER TENSION RESPONSES GENERATED BY VARIOUS LEVELS OF INTERSECTION ILLUMINATION A Thesis By WELDON CLIFFORD FRANKLIN Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1962 Major Subj ect: Civil Engineering DRIVER TENSION RESPONSES GENERATED BY VARIOUS LEVELS OF INTERSECTION ILLUMINATION A Thesis By WELDON CLIFFORD FRANKLIN Approved as to style and content by...

  4. Analyzing Vehicle Fuel Saving Opportunities through Intelligent Driver Feedback

    SciTech Connect (OSTI)

    Gonder, J.; Earleywine, M.; Sparks, W.

    2012-06-01T23:59:59.000Z

    Driving style changes, e.g., improving driver efficiency and motivating driver behavior changes, could deliver significant petroleum savings. This project examines eliminating stop-and-go driving and unnecessary idling, and also adjusting acceleration rates and cruising speeds to ideal levels to quantify fuel savings. Such extreme adjustments can result in dramatic fuel savings of over 30%, but would in reality only be achievable through automated control of vehicles and traffic flow. In real-world driving, efficient driving behaviors could reduce fuel use by 20% on aggressively driven cycles and by 5-10% on more moderately driven trips. A literature survey was conducted of driver behavior influences, and pertinent factors from on-road experiments with different driving styles were observed. This effort highlighted important driver influences such as surrounding vehicle behavior, anxiety over trying to get somewhere quickly, and the power/torque available from the vehicle. Existing feedback approaches often deliver efficiency information and instruction. Three recommendations for maximizing fuel savings from potential drive cycle improvement are: (1) leveraging applications with enhanced incentives, (2) using an approach that is easy and widely deployable to motivate drivers, and (3) utilizing connected vehicle and automation technologies to achieve large and widespread efficiency improvements.

  5. EC Driver - 41" Stroke Hydraulic Cylinder

    SciTech Connect (OSTI)

    Jaques, A.; /Fermilab

    1990-05-24T23:59:59.000Z

    It was decided to use a hydraulic cylinder resting on the floor of the argon spill trough in the EC carriage to drive the EC's motion on the center beam. Space was limited due to the spill bellows and their required support and containment system. The 0.0. of the cylinder had to be limited to 3 to 3-1/2 inches, maximum. The weight of a wet EC and carriage is estimated to be 320 tons. The rolling coefficient of friction of the Tychoway rollers chosen to guide the EC and carriage along the hardened centerbeam ways is claimed to be less than 0.0025. The driver will also need to overcome the forces produced by moving (rotating) the numerous bayonets located at the top of the cryostats in the many piping systems. These forces were conservatively estimated at 1000 lbs. The drive force required to overcome these forces was then calculated to be: 320(2,000) x 0.0025 + 1,000 = 2.600 lbs. (min. required). Due to the uncertainty in the actual roller coefficient of friction and the various unknowns in estimating the resistive forces contained in the piping and cabling systems attached to the cryostat, a conservative design factor of 5 was chosen. This should account for any uncertainty in our estimation of the minimum required drive force and also leaves us with a reserve to fall back on in case any unforeseen problems might arise. Thus the desired capacity of the driver was set at: (2,600) x 5 = 13,000 lbs. (design capacity). Assuming a 3 inch O.D. cylinder with a 1/2 inch wall (2 inch bore), we first analyzed a 1-3/8 inch diameter piston rod. Using Shigley & Mischke's 'Mechanical Engineering Design' (5th Ed.) and it's formulas for long columns with central loading, it was determined that a 1-3/8 inch diameter rod would not suffice, given our safety factor of 2. Increasing the piston rod diameter to 1-1/2 inches proved to be sufficient. The maximum allowable load came out to be approximately 17,000 lbs., which is greater than the 13,000 lbs. design capacity. With a 1-1/2 inch rod, a 2 inch bore and 10,000 psi capacity, the maximum return (retraction) force is: ({pi}/4)(2{sup 2}-1.52) x (10,000) = 13,744 lbs. (return force). This meets the desired design capacity of the cylinder. On the extension of the cylinder, the pressure will be limited such to produce only the 13,000 lb. design capacity. Through the use of a regulator on the cylinder extension inlet, the pressure will be limited to: 13,000/[({pi}/4)(2){sup 2}] {approx_equal} 4,200 psi. (regulator setting) and 4,200 x ({pi}/4)(2){sup 2} = 13,195 lbs. (thrust force). Another reference used by some Fermi engineers in designing hydraulic cylinders is the 'Design Engineers Handbook', Bulletin 0224-B1 published by the Parker-Hannifin Corporation. The piston rod-stroke selection table on page b-5 is used to determine the stroke factor. Our setup most approximates Case II of the table which gives a stroke factor of 0.70. Multiplying this by the actual stroke (41-inch) gives us a basic length of 28.7-inch. Using the piston rodstroke selection graph on page b-6, the 1-1/2 inch rod and 28.7-inch basic length indicate an allowable thrust of approximately 13,000 lbs. According to the Chief Application Engineer at the Parker-Hannifin regional sales office in Des Plaines, IL, a min imum safety factor of 4 can be assumed in the piston rod-stroke selection graph, possibly even higher. This would be at least twice as high as our initial safety factor of 2. Thus we feel our cylinder design falls well within the acceptable region of this reference.

  6. Plans for a proton driver at Fermilab

    SciTech Connect (OSTI)

    Kephart, R.D.; /Fermilab

    2005-01-01T23:59:59.000Z

    During the last several years, stunning experimental results have established that neutrinos have nonzero masses and substantial mixing. The Standard Model must be extended to accommodate neutrino mass terms. The observation that neutrino masses and mass splittings are all many orders of magnitude smaller than those of any of the other fundamental fermions suggests radically new physics, perhaps originating at the GUT or Planck Scale, or perhaps the existence of new spatial dimensions. In some sense we know that the Standard Model is broken, but we don't know how it is broken. Whatever the origin of the observed neutrino masses and mixing, it is likely to require a profound extension to our picture of the physical world. The first steps in understanding this revolutionary new physics are to pin down the measurable parameters and to address the next round of basic questions: (1) Are there only three neutrino flavors, or do light, sterile neutrinos exist? (2) If there are only three generations, there is one angle ({theta}{sub 13}) in the mixing matrix that is unmeasured. How large is it? (3) Which of the two possible orderings of the neutrino mass eigenstates applies? (4) If {theta}{sub 13} is large enough one it may be possible to measure the quantum-mechanical phase {delta}. If {theta}{sub 13} and {delta} are non-zero there will be CP violation in the lepton sector. These questions can be addressed by accelerator based neutrino oscillation experiments. The answers will guide our understanding of what lies beyond the Standard Model, and whether the new physics provides an explanation for the baryon asymmetry of the Universe (via leptogenesis), or provides deep insight into the connection between quark and lepton properties (via Grand Unified Theories), or perhaps leads to an understanding of one of the most profound questions in physics: Why are there three generations of quarks and leptons? The answers may well further challenge our picture of the physical world, and will certainly have important implications for our understanding of cosmology and the evolution of the early Universe. The current Fermilab Program is an important part of the world-wide accelerator based effort to explore and understand the physics of neutrino oscillations. By early 2005, with both MINOS and MiniBooNE taking data, Fermilab will be able to answer some of the most pressing first-round questions raised by the discovery that neutrinos have mass. Fermilab's high-intensity neutrino beams are derived from 8- and 120-GeV proton beams. MiniBooNE is currently taking data using 8 GeV Protons from the Booster. The 120 GeV NuMI beam will start to operate in early 2005 using a 0.25 MW proton beam power from the Main Injector. Future neutrino programs will build on these existing facilities. New short and long baseline experiments have been proposed. There are proposals to increase the available number of protons at 8 and 120 GeV with the goal of addressing the full range of questions presented by neutrino oscillations. Key to that vision is a new intense proton source that usually is referred to as the Proton Driver.

  7. BEAM SIMULATIONS USING VIRTUAL DIAGNOSTICS FOR THE DRIVER LINAC

    SciTech Connect (OSTI)

    R. C. York; X. Wu; Q. Zhao

    2011-12-21T23:59:59.000Z

    End-to-end beam simulations for the driver linac have shown that the design meets the necessary performance requirements including having adequate transverse and longitudinal acceptances. However, to achieve reliable operational performance, the development of appropriate beam diagnostic systems and control room procedures are crucial. With limited R&D funding, beam simulations provide a cost effective tool to evaluate candidate beam diagnostic systems and to provide a critical basis for developing early commissioning and later operational activities. We propose to perform beam dynamic studies and engineering analyses to define the requisite diagnostic systems of the driver linac and through simulation to develop and test commissioning and operational procedures.

  8. Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

    E-Print Network [OSTI]

    Zhang, GuangJun

    The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we ...

  9. Driver mental workload requirements on horizontal curves based on occluded vision test measurements

    E-Print Network [OSTI]

    Shafer, Mark Anthony

    1994-01-01T23:59:59.000Z

    This thesis documents an evaluation of driver mental workload requirements on horizontal curves based on occluded vision test measurements. Driver workload is an important concept in the design of highway systems. A successful highway design...

  10. Evaluation of driver braking performance to an unexpected object in the roadway 

    E-Print Network [OSTI]

    Picha, Dale Louis

    1994-01-01T23:59:59.000Z

    components, specifically whether the equation accurately reflects driver and vehicle behaviors during a braking maneuver. This research evaluated the two components of the SSD equation. Four field studies were conducted that evaluated driver braking...

  11. Final Report on the Fuel Saving Effectiveness of Various Driver Feedback Approaches

    SciTech Connect (OSTI)

    Gonder, J.; Earleywine, M.; Sparks, W.

    2011-03-01T23:59:59.000Z

    This final report quantifies the fuel-savings opportunities from specific driving behavior changes, identifies factors that influence drivers' receptiveness to adopting fuel-saving behaviors, and assesses various driver feedback approaches.

  12. Evaluation of driver braking performance to an unexpected object in the roadway

    E-Print Network [OSTI]

    Picha, Dale Louis

    1994-01-01T23:59:59.000Z

    components, specifically whether the equation accurately reflects driver and vehicle behaviors during a braking maneuver. This research evaluated the two components of the SSD equation. Four field studies were conducted that evaluated driver braking...

  13. Running head: STEREOTYPE THREAT IN OLDER ADULTS 1 Stereotype threat can enhance, as well as impair, older adults' memory

    E-Print Network [OSTI]

    Mather, Mara

    Running head: STEREOTYPE THREAT IN OLDER ADULTS 1 Stereotype threat can enhance, as well as impair, and Rico Velasco for research assistance and to Dr. Tom Hess for providing us with the stereotype threat for publication. #12;STEREOTYPE THREAT IN OLDER ADULTS 2 Abstract (150) Negative stereotypes about aging can

  14. Termites, elephants and fire are key drivers of tree mortality

    E-Print Network [OSTI]

    mortality: 2 dominated by elephant damage, 2 by termite attack and 1 by fire. Wind and human activity wereTermites, elephants and fire are key drivers of tree mortality 5 plots suffered substantial tree not major causes of tree mortality. Sample sizes are too small to reasonably determine the most significant

  15. Next Story > SC DMV lifting drivers' suspensions this week

    E-Print Network [OSTI]

    Duchowski, Andrew T.

    The State Next Story > SC DMV lifting drivers' suspensions this week Researcher: Zombie fads peak COLUMBIA, S.C. -- Zombies seem to be everywhere these days. In the popular TV series "The Walking Dead at the University of California at Davis. Lauro said she keeps track of zombie movies, TV shows and video games

  16. Energy for 500 million Homes: Drivers and Outlook for

    E-Print Network [OSTI]

    -up analysis of residential building energy consumption in China using data from a wide variety of sourcesLBNL-2417E Energy for 500 million Homes: Drivers and Outlook for Residential Energy Consumption and Outlook for Residential Energy Consumption in China Nan Zhou*, Michael A. McNeil, Mark Levine Keywords

  17. Project: Driver and controller for a thermoelectric cooler

    E-Print Network [OSTI]

    Project: Driver and controller for a thermoelectric cooler Supervisor: Prof. Sam Ben-Yaakov Year solutions. Based on one of the three thermoelectric phenomena ­ the Peltier effect ­ bi-directional control is achieved. The TEC (which is a Thermoelectric Cooler) uses this effect. The direction of the current through

  18. Integrating Concurrency Control and Energy Management in Device Drivers

    E-Print Network [OSTI]

    Levis, Philip

    Integrating Concurrency Control and Energy Management in Device Drivers Kevin Klues , Vlado@cs.berkeley.edu dgay@intel-research.net Abstract Energy management is a critical concern in wireless sensornets. De- spite its importance, sensor network operating systems today pro- vide minimal energy management support

  19. Improved gauge driver for the generalized harmonic Einstein system Lee Lindblom and Bela Szilagyi

    E-Print Network [OSTI]

    Lindblom, Lee

    Improved gauge driver for the generalized harmonic Einstein system Lee Lindblom and Be´la Szila´gyi

  20. A method for calibration of bone driver transducers to measure the mastoid impedance Reggie Weecea

    E-Print Network [OSTI]

    Allen, Jont

    bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver by known masses. This absolute calibration is based upon a circuit model of the driver, describing specialized equipment not available in the clinic, and a refined bone driver circuit model is proposed

  1. Research Paper A method for calibration of bone driver transducers to measure the mastoid

    E-Print Network [OSTI]

    Allen, Jont

    vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends. This absolute calibration is based upon a circuit model of the driver, describing it with three frequency in the clinic, and a refined bone driver circuit model is proposed to better capture the observed behaviors. Ã?

  2. Testing Closed-Source Binary Device Drivers with DDT Volodymyr Kuznetsov, Vitaly Chipounov, and George Candea

    E-Print Network [OSTI]

    Candea, George

    Testing Closed-Source Binary Device Drivers with DDT Volodymyr Kuznetsov, Vitaly Chipounov (EPFL), Switzerland Abstract DDT is a system for testing closed-source binary de- vice drivers against think of it as a pesticide against device driver bugs. DDT combines virtualization with a spe- cialized

  3. Design and Evaluation of a Safe Driver Machine Interface ANDREA BONDAVALLI5

    E-Print Network [OSTI]

    Firenze, Università degli Studi di

    Computer (EVC) and the Driver Machine Interface (DMI). The EVC is the core of the on- board ATC system; it supervises the movement of the train by using the information re- ceived from the trackside systems. The DMI is the interface between the EVC and the driver; it acquires driver's commands and transforms EVC commands

  4. Journal of Transportation Engineering Modelling Automobile Driver's Toll-Lane Choice Behaviour at a Toll Plaza

    E-Print Network [OSTI]

    Kundu, Debasis

    Journal of Transportation Engineering Modelling Automobile Driver's Toll-Lane Choice Behaviour at a Toll Plaza --Manuscript Draft-- Manuscript Number: TEENG-1181R3 Full Title: Modelling Automobile Driver to develop a random utility based discrete multinomial choice model for the behaviour of automobile drivers

  5. Factors that influence exercise participation amoung older adults

    E-Print Network [OSTI]

    Murphey, Kristina Kile

    2001-01-01T23:59:59.000Z

    The purpose of this study was to survey adults age 60 and older to measure their levels of exercise self-efficacy, attitudes toward exercise and health, and perceived exercise control beliefs. Participants also defined other intrapersonal factors...

  6. Health Status and Health Literacy in Older Adults

    E-Print Network [OSTI]

    Fulton, Daphne Saxon

    2014-08-04T23:59:59.000Z

    This study aimed to examine the relationship between health literacy and the health status of older adults. The first section of the study consisted of a comprehensive literature review of prior research regarding cognitive, health, and behavioral...

  7. Learning Dialogue Strategies from Older and Younger Simulated Users 

    E-Print Network [OSTI]

    Kallirroi, Georgila; Wolters, Maria K.; Moore, Johanna D.

    2010-10-28T23:59:59.000Z

    Older adults are a challenging user group because their behaviour can be highly variable. To the best of our knowledge, this is the first study where dialogue strategies are learned and evaluated with both simulated younger ...

  8. Patterns of Rumination by Young and Older Adults

    E-Print Network [OSTI]

    Schmalzried, RaLynn Cheri

    2012-05-31T23:59:59.000Z

    A lot of attention has been given to the negative effects of both inhibitory deficits and rumination but little work has compared both: research on inhibitory deficits has focused on older adults whereas research on ...

  9. Older adult consumers of Texas public mental health services:

    E-Print Network [OSTI]

    Karlin, Bradley Eric

    2002-01-01T23:59:59.000Z

    at disproportionately low rates. Although recent changes in public policies and perceptions portend improved access to mental health services, we cannot assume that older adults are finding their way into the therapy room and receiving treatment. The present study...

  10. Low-jitter, hydrogen thyratron Pockels cell driver

    SciTech Connect (OSTI)

    Oicles, J.A.; Kitchin, H.D.

    1983-06-01T23:59:59.000Z

    The requirements to be met by Pockels cell drivers for incorporation into the Novette and Nova Laser systems are presented, and critical aspects of the specification examined. A high-performance pulse generator has been developed to meet these requirements using new thyratron technology from the English Electric Valve Co. Ltd. Two closely related versions have been built; a 10KV output unit with 9 nsec risetime into five parallel 50-ohm loads and a faster 5KV output driver with 3.5 nsec risetime into a single 50-ohm load. The design approach for optimizing performance, using the new tubes in relation to the LLNL specification is described, including the techniques used for control of electromagnetic interference.

  11. Simple SPICE model for comparison of CMOS output driver circuits

    E-Print Network [OSTI]

    Hermann, John Karl

    1993-01-01T23:59:59.000Z

    to monitor the ground nodes of output driver circuits for noise. Both relative performance and noise levels are generated through the simulations. A test device was built to confirm that the model was effective in speed and noise comparisons. Values were... on CMOS technologies. Journal model is IEEE 'I?ansactions on Automatic Control. A. Literature Survey Research has been done in the past concerning noise generated by digital logic de- vices. In particular, Advanced CMOS Logic (ACL) integrated circuits...

  12. 59136 Federal Register / Vol. 75, No. 186 / Monday, September 27, 2010 / Rules and Regulations (c) Certain farm vehicle drivers. The

    E-Print Network [OSTI]

    ) Certain farm vehicle drivers. The rules in this part except for § 391.15(e) do not apply to a farm vehicle driver except a farm vehicle driver who drives an articulated (combination) commercial motor vehicle, as defined in § 390.5. For limited exemptions for farm vehicle drivers of articulated commercial motor

  13. Talking about living and dying with the oldest old: public involvement in a study on end of life care in care homes.

    E-Print Network [OSTI]

    Goodman, Claire; Mathie, Elspeth; Cowe, Marion; Mendoza, Alex; Westwood, Daphne; Munday, Diane; Wilson, Patricia M; Crang, Clare; Froggatt, Katherine; Iliffe, Steve; Manthorpe, Jill; Gage, Heather; Barclay, Stephen

    2011-11-23T23:59:59.000Z

    , governance and safeguarding, and the discussion and interpretation of emergent findings with the older people living in the care homes. PPI as collaborators in the recruitment process Recruitment to the study was a staged process, that involved securing care... expressed doubts about participation Table 1 Public involvement in different stages of research process PIR Involvement Level of Involvement Study Design Input on grant proposal and development of method for public involvement within the study Steering...

  14. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor andPublic Involvement

  15. The effects of driver gas contamination on shock tube test time

    E-Print Network [OSTI]

    Hawkins, Garry Owen

    1970-01-01T23:59:59.000Z

    THE EFFECTS OF DRIVER GAS CONTAMINATION ON SHOCK TUBE TEST TIME A Thesis by CARRY OWEN HAWKINS Approved as to style and content by: (Chairman of Committee) (Head of Department) (Memb e r) (Member) (Member) (Membe r) (Member) December 1970... AB S TRACT The Effects of Driver Gas Contamination on Shock Tube Test Time. (December 1970) Garry 0. Hawkins, B. S. , Texas A&M University; Directed by: Dr. Richard E. Thomas The effects of driver gas contamination are manifested in a change...

  16. P5 Science Drivers: Accelerator Experiments Panagiotis Spentzouris

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible for RenewableSpeedingBiomass and BiofuelsOversight BoardP-GlycoproteiniiiScience Drivers:

  17. Philips Light Sources & Electronics is Developing an Efficient, Smaller, Cost-Effective Family of LED Drivers

    Broader source: Energy.gov [DOE]

    With the help of DOE funding, Philips Light Sources & Electronics is developing a new family of LED drivers that are more efficient and cost-effective as well as smaller in size than currently available drivers. The new drivers are switch-mode power supplies that are similar to today's drivers, but with an improved design. In addition, they have a different topology—boost plus LLC—for wattages of 40W and above, but they retain the commonly used flyback topology at lower wattages.

  18. Factors Associated with Hit-and-Run Pedestrian Fatalities and Driver Identification

    E-Print Network [OSTI]

    MacLeod, Kara E.; Griswold, Julia; Arnold, Lindsay S.; Ragland, David R

    2010-01-01T23:59:59.000Z

    Hit-and-run Crashes. Accident Analysis and Prevention, Vol.Circumstances and Drivers. Accident Analysis and Prevention,Hit-and-run Crashes. Accident Analysis and Prevention, Vol.

  19. UWB multi-burst transmit driver for averaging receivers

    DOE Patents [OSTI]

    Dallum, Gregory E

    2012-11-20T23:59:59.000Z

    A multi-burst transmitter for ultra-wideband (UWB) communication systems generates a sequence of precisely spaced RF bursts from a single trigger event. There are two oscillators in the transmitter circuit, a gated burst rate oscillator and a gated RF burst or RF power output oscillator. The burst rate oscillator produces a relatively low frequency, i.e., MHz, square wave output for a selected transmit cycle, and drives the RF burst oscillator, which produces RF bursts of much higher frequency, i.e., GHz, during the transmit cycle. The frequency of the burst rate oscillator sets the spacing of the RF burst packets. The first oscillator output passes through a bias driver to the second oscillator. The bias driver conditions, e.g., level shifts, the signal from the first oscillator for input into the second oscillator, and also controls the length of each RF burst. A trigger pulse actuates a timing circuit, formed of a flip-flop and associated reset time delay circuit, that controls the operation of the first oscillator, i.e., how long it oscillates (which defines the transmit cycle).

  20. Gaz de France ordering high-efficiency drivers

    SciTech Connect (OSTI)

    de Biasi, V.

    1980-11-01T23:59:59.000Z

    For natural gas transmission, distribution, and storage operations, Gaz de France is installing Creusot-Loire's new line of high-efficiency gas-turbine packages, powered by Allison 501 and 570 generators for compressor speeds exceeding 10,000 rpm. The Type CA.3 driver comprises a 501 generator coupled to a two-stage power turbine; the ISO base rating is 3265 kW on gas fuel with a heat rate of 12,050 Btu/kWhr. The CA.5 driver with the stronger 570 gas-turbine engine is base-rated at 4805 kW with a heat rate of 11,360 Btu/kWhr. Designed for direct-drive, with no intermediary gearing, the high-speed compressor operates on the 13,820-rpm output shaft speed of the CA.3 for baseload requirements or on 11,500 rpm for the more powerful CA.5 set. These compressor packages will serve as boosters for the transmission and storage of regasified LNG from Algeria and natural gas from the North Sea, USSR, and France's own Lacq fields.

  1. Blue oak seedlings may be older than they look

    E-Print Network [OSTI]

    Standiford, Richard B.

    Blue oak seedlings may be older than they look Ralph L. Phillips u Neil K. McDougald o Richard B. Standiford William E.Frost A 4-year study indicates that na- tive blue oak seedlings are prob- ably much the year of above- average rainfall. Blue oak (Quercusdouglasii)trees are a valuable economic and aesthetic

  2. RETIREMENT TRENDS AND POLICIES TO ENCOURAGE WORK AMONG OLDER AMERICANS

    E-Print Network [OSTI]

    Huang, Jianyu

    retirement over much of the last century. Many public policies and private institutions that encouraged early are to be believed, most workers favor preserving the institutions that allow early retirement even if it meansRETIREMENT TRENDS AND POLICIES TO ENCOURAGE WORK AMONG OLDER AMERICANS by GARY BURTLESS AND JOSEPH

  3. Marine Iguanas Older Than Their Islands Jeff Mitton

    E-Print Network [OSTI]

    Mitton, Jeffry B.

    Marine Iguanas Older Than Their Islands Jeff Mitton Natural Selections (Appeared in the Boulder Camera, December 11, 2009) The Galapagos Islands ride on the Nazca plate, a tectonic plate drifting toward Ecuador at the rate of one and a half inches per year. But the Galapagos Islands will never reach

  4. Shaping the output pulse of a linear-transformer-driver module W. A. Stygar,1

    E-Print Network [OSTI]

    Shaping the output pulse of a linear-transformer-driver module W. A. Stygar,1 W. E. Fowler,1 K. R a linear-transformer- driver (LTD) module that drives an internal water-insulated transmission line-insulated radial-transmission-line impedance transformers [Phys. Rev. ST Accel. Beams 11, 030401 (2008)]. DOI: 10

  5. Submitted to Vehicle System Dynamics An Adaptive Lateral Preview Driver Model

    E-Print Network [OSTI]

    Peng, Huei

    of the vehicle. The proposed driver model is developed using the adaptive predictive control (APC) framework inspires our interest in understanding human steering actions and the development of a driver model on the response of the vehicle. These tests can be performed with a steering and speed control robot, and thus can

  6. 1 Drivers of the projected changes to the Pacific Ocean 2 equatorial circulation

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Drivers of the projected changes to the Pacific Ocean 2 equatorial circulation 3 A. Sen Gupta,1 A), 29 Drivers of the projected changes to the Pacific Ocean equatorial 30 circulation, Geophys. Res. Lett., 39, LXXXXX, doi:10.1029/ 31 2012GL051447. 32 1. Introduction 33 [2] The equatorial Pacific Ocean

  7. AABBSSTTRRAACCTT MA, RUIQI. The Effect of In-Vehicle Automation and Reliability on Driver Situation

    E-Print Network [OSTI]

    Kaber, David B.

    AABBSSTTRRAACCTT MA, RUIQI. The Effect of In-Vehicle Automation and Reliability on Driver Situation by automation and in- vehicle device use. Specifically, this study investigated the implications of adaptive; investigate the effect of varying reliability of in-vehicle automation (navigation aids) on driver SA

  8. Nighttime driver needs: an analysis of sign usage based on luminance

    E-Print Network [OSTI]

    Clark, Jerremy Eugene

    2007-09-17T23:59:59.000Z

    ? With brighter signs being visible from farther away, there is an increased opportunity for the driver to look at the sign. This thesis assesses the impact of sign brightness on the nighttime driver�s sign viewing behavior; such as the number of glances...

  9. Expert Recommendation based on Social Drivers, Social Network Analysis, and Semantic Data Representation

    E-Print Network [OSTI]

    Fox, Mark S.

    Expert Recommendation based on Social Drivers, Social Network Analysis, and Semantic Data-Theoretical Multi-Level (MTML) framework which investigates social drivers for network formation in the communities computational techniques from social network analysis and representational techniques from the semantic web

  10. UC SANTA BARBARA POLICY AND PROCEDURE Driving Records for Designated Employees and Drivers

    E-Print Network [OSTI]

    Bigelow, Stephen

    when employees are convicted of motor vehicle violations and when actions are taken against a driver a special certificate (ambulance, private school bus, farm labor vehicle, special construction equipment with this policy. C. There are criminal penalties for employing or continuing to employ as a driver a person who

  11. Catadioptric Sensor for a Simultaneous Tracking of the Driver's Face and the Road Scene

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    using head mounted devices but these systems are too intrusive in the driving task. The most popular non-intrusive to be non-intrusive and compact (to avoid distracting the driver in his task), able to observe the driver on Omnidirectional Vision, Camera Networks and Non-classical Cameras - OMNIVIS (2008)" #12;2 J-F. Layerle, X

  12. STATE OF CALIFORNIA -GENERAL SERVICES -RISK AND INSURANCE MANAGEMENT STATE DRIVER ACCIDENT REVIEW

    E-Print Network [OSTI]

    Ponce, V. Miguel

    STATE OF CALIFORNIA - GENERAL SERVICES - RISK AND INSURANCE MANAGEMENT STATE DRIVER ACCIDENT REVIEW STD. 274 (REV. 1/2003) PLEASE PRINT OR TYPE SUPERVISOR'S REVIEW - FOR DEPARTMENTAL ACCIDENT PREVENTION PURPOSE: To have supervisor investigate each driver accident, report facts and circumstances, confirm

  13. Dynamical 3-Space: Supernovae and the Hubble Expansion - Older Universe and End of Dark Energy

    E-Print Network [OSTI]

    Reginald T Cahill

    2007-06-05T23:59:59.000Z

    We apply the new dynamics of 3-space to cosmology by deriving a Hubble expansion solution. This dynamics involves two constants; G and alpha - the fine structure constant. This solution gives an excellent parameter-free fit to the recent supernova and gamma-ray burst data without the need for `dark energy' or `dark matter'. The data and theory together imply an older age for the universe of some 14.7Gyrs. Various problems such as fine tuning, the event horizon problem etc are now resolved. A brief review discusses the origin of the 3-space dynamics and how that dynamics explained the bore hole anomaly, spiral galaxy flat rotation speeds, the masses of black holes in spherical galaxies, gravitational light bending and lensing, all without invoking `dark matter' or `dark energy'. These developments imply that a new understanding of the universe is now available.

  14. The Effects of Varying Task Priorities on Language Production by Young and Older Adults

    E-Print Network [OSTI]

    Kemper, Susan; Schmalzried, RaLynn Cheri; Herman, Ruth; Mohankumar, Deepthi

    2011-02-01T23:59:59.000Z

    The present study compared how varying task priorities affected young and older adults' language production. Both young and older adults responded to monetary incentives to vary their performance when simultaneously talking ...

  15. Older Adults in Nursing Homes: Assessing Relationships Between Multiple Constructs of Social Integration, Facility Characteristics, and Health

    E-Print Network [OSTI]

    Leedahl, Skye N.

    2013-05-31T23:59:59.000Z

    An extensive body of research has examined connections between older adults' social worlds and health and well-being, particularly for community-dwelling older adults. Yet, little is known about the social worlds of older ...

  16. Linac-Based Proton Driver for a Neutrino Factory

    E-Print Network [OSTI]

    Garoby, R; Aiba, M; Meddahi, M

    2009-01-01T23:59:59.000Z

    A Neutrino Factory Proton Driver based on a superconducting proton linac has been designed in the CERN context. The 5 GeV/4 MW H- beam from the linac is accumulated using charge exchange injection in a fixed-energy synchrotron and afterwards transferred to a compressor ring, where bunch rotation takes place. The lattices of the accumulator and compressor are described, as well as magnet technology and RF manipulations. Critical issues related to charge-exchange injection, space-charge effects in the compressor and beam stability in the accumulator, are addressed. The analysis is focused on the baseline scenario, which provides 6 bunches on the target. Results of preliminary analysis of options with less bunches (three and one) are also presented.

  17. Recirculating induction accelerators as drivers for heavy ion fusion

    SciTech Connect (OSTI)

    Barnard, J.J.; Deadrick, F.; Friedman, A.; Grote, D.P.; Griffith, L.V.; Kirbie, H.C.; Neil, V.K.; Newton, M.A.; Paul, A.C.; Sharp, W.M.; Shay, H.D. (Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)); Bangerter, R.O.; Faltens, A.; Fong, C.G.; Judd, D.L.; Lee, E.P.; Reginato, L.L.; Yu, S.S. (Lawrence Berkeley Laboratory, Berkeley, California 94720 (United States)); Godlove, T.F. (FM Technologies, Inc., 10529-B Braddock Rd., Fairfax, Virginia 22302 (United States))

    1993-07-01T23:59:59.000Z

    A two-year study of recirculating induction heavy ion accelerators as low-cost driver for inertial-fusion energy applications was recently completed. The projected cost of a 4 MJ accelerator was estimated to be about $500 M (million) and the efficiency was estimated to be 35%. The principal technology issues include energy recovery of the ramped dipole magnets, which is achieved through use of ringing inductive/capacitive circuits, and high repetition rates of the induction cell pulsers, which is accomplished through arrays of field effect transistor (FET) switches. Principal physics issues identified include minimization of particle loss from interactions with the background gas, and more demanding emittance growth and centroid control requirements associated with the propagation of space-charge-dominated beams around bends and over large path lengths. In addition, instabilities such as the longitudinal resistive instability, beam-breakup instability and betatron-orbit instability were found to be controllable with careful design.

  18. Low impedance z-pinch drivers without post-hole convolute current adders.

    SciTech Connect (OSTI)

    Savage, Mark Edward; Seidel, David Bruce; Mendel, Clifford Will, Jr.

    2009-09-01T23:59:59.000Z

    Present-day pulsed-power systems operating in the terawatt regime typically use post-hole convolute current adders to operate at sufficiently low impedance. These adders necessarily involve magnetic nulls that connect the positive and negative electrodes. The resultant loss of magnetic insulation results in electron losses in the vicinity of the nulls that can severely limit the efficiency of the delivery of the system's energy to a load. In this report, we describe an alternate transformer-based approach to obtaining low impedance. The transformer consists of coils whose windings are in parallel rather than in series, and does not suffer from the presence of magnetic nulls. By varying the pitch of the coils windings, the current multiplication ratio can be varied, leading to a more versatile driver. The coupling efficiency of the transformer, its behavior in the presence of electron flow, and its mechanical strength are issues that need to be addressed to evaluate the potential of transformer-based current multiplication as a viable alternative to conventional current adder technology.

  19. Computer use by older adults: A multi-disciplinary review Nicole Wagner, Khaled Hassanein *, Milena Head

    E-Print Network [OSTI]

    Hitchcock, Adam P.

    Review Computer use by older adults: A multi-disciplinary review Nicole Wagner, Khaled Hassanein f o Article history: Available online 22 April 2010 Keywords: Older adults Aging Computer use of computer and Internet users. In many cases, older adults are the fastest growing computer and Internet user

  20. Retrofit Analysis of Older, Single Family Housing in San Antonio

    E-Print Network [OSTI]

    Rashed-Ali, H.

    2013-01-01T23:59:59.000Z

    of San Antonio has 28 historic districts, • Potential energy savings from retrofit of older homes are substantial and undisputed. However: • Historic homes need thoughtful attention to the details and features that cause society to give them protected... listings due to their cultural heritage value. Front porch of case study home 1 ESL-KT-13-12-05 CATEE 2013: Clean Air Through Energy Efficiency Conference, San Antonio, Texas Dec. 16-18 Background • An energy efficient and sustainable building can reduce...

  1. Sliding Mode Pulsed Averaging IC Drivers for High Brightness Light Emitting Diodes

    SciTech Connect (OSTI)

    Dr. Anatoly Shteynberg, PhD

    2006-08-17T23:59:59.000Z

    This project developed new Light Emitting Diode (LED) driver ICs associated with specific (uniquely operated) switching power supplies that optimize performance for High Brightness LEDs (HB-LEDs). The drivers utilize a digital control core with a newly developed nonlinear, hysteretic/sliding mode controller with mixed-signal processing. The drivers are flexible enough to allow both traditional microprocessor interface as well as other options such as “on the fly” adjustment of color and brightness. Some other unique features of the newly developed drivers include • AC Power Factor Correction; • High power efficiency; • Substantially fewer external components should be required, leading to substantial reduction of Bill of Materials (BOM). Thus, the LED drivers developed in this research : optimize LED performance by increasing power efficiency and power factor. Perhaps more remarkably, the LED drivers provide this improved performance at substantially reduced costs compared to the present LED power electronic driver circuits. Since one of the barriers to market penetration for HB-LEDs (in particular “white” light LEDs) is cost/lumen, this research makes important contributions in helping the advancement of SSL consumer acceptance and usage.

  2. Physics at an upgraded proton driver at Fermilab

    SciTech Connect (OSTI)

    Steve Geer

    2004-07-28T23:59:59.000Z

    The accelerator-based particle physics program in the US is entering a period of transition. This is particularly true at Fermilab which for more than two decades has been the home of the Tevatron Proton-Antiproton Collider, the World's highest energy hadron collider. In a few years time the energy frontier will move to the LHC at CERN. Hence, if an accelerator-based program is to survive at Fermilab, it must evolve. Fermilab is fortunate in that, in addition to hosting the Tevatron Collider, the laboratory also hosts the US accelerator-based neutrino program. The recent discovery that neutrino flavors oscillate has opened a new exciting world for us to explore, and has created an opportunity for the Fermilab accelerator complex to continue to address the cutting-edge questions of particle physics beyond the Tevatron Collider era. The presently foreseen neutrino oscillation experiments at Fermilab (MiniBooNE [1] and MINOS [2]) will enable the laboratory to begin contributing to the Global oscillation physics program in the near future, and will help us better understand the basic parameters describing the oscillations. However, this is only a first step. To be able to pin down all of the oscillation parameters, and hopefully make new discoveries along the way, we will need high statistics experiments, which will require a very intense neutrino beam, and one or more very massive detectors. In particular we will require new MW-scale primary proton beams and perhaps ultimately a Neutrino Factory [3]. Plans to upgrade the Fermilab Proton Driver are presently being developed [4]. The upgrade project would replace the Fermilab Booster with a new 8 GeV accelerator with 0.5-2 MW beam power, a factor of 15-60 more than the current Booster. It would also make the modifications needed to the Fermilab Main Injector (MI) to upgrade it to simultaneously provide 120 GeV beams of 2 MW. This would enable a factor of 5-10 increase in neutrino beam intensities at the MI, while also supporting a vigorous 8 GeV fixed-target program. In addition, a Proton Driver might also serve as a stepping-stone to future accelerators, both as an R&D test bed and as an injector, with connections to the Linear Collider, Neutrino Factories, and a VLHC. Hence, although neutrino physics would provide the main thrust for the science program at an upgraded Fermilab proton source, the new facility would also offer exciting opportunities for other fixed-target particle physics (kaons, muons, neutrons, antiprotons, etc.) and a path towards new accelerators in the future.

  3. Dynamic analysis of policy drivers for bioenergy commodity markets

    SciTech Connect (OSTI)

    Robert F. Jeffers; Jacob J. Jacobson; Erin M. Searcy

    2001-01-01T23:59:59.000Z

    Biomass is increasingly being considered as a feedstock to provide a clean and renewable source of energy in the form of both liquid fuels and electric power. In the United States, the biofuels and biopower industries are regulated by different policies and have different drivers which impact the maximum price the industries are willing to pay for biomass. This article describes a dynamic computer simulation model that analyzes future behavior of bioenergy feedstock markets given policy and technical options. The model simulates the long-term dynamics of these markets by treating advanced biomass feedstocks as a commodity and projecting the total demand of each industry as well as the market price over time. The model is used for an analysis of the United States bioenergy feedstock market that projects supply, demand, and market price given three independent buyers: domestic biopower, domestic biofuels, and foreign exports. With base-case assumptions, the biofuels industry is able to dominate the market and meet the federal Renewable Fuel Standard (RFS) targets for advanced biofuels. Further analyses suggest that United States bioenergy studies should include estimates of export demand in their projections, and that GHG-limiting policy would partially shield both industries from exporter dominance.

  4. Temperature as a driver for the expansion of the microalga Gonyostomum semen in Swedish lakes

    E-Print Network [OSTI]

    Temperature as a driver for the expansion of the microalga Gonyostomum semen in Swedish lakes Karin is an example of invasive harmful microalgae (Neilan et al., 2003). Another presumably invasive species

  5. Fourth Annual Ethical Leadership Conference Panel Drivers, Challenges, and Strategies for Future of Corporate

    E-Print Network [OSTI]

    Lin, Xiaodong

    Fourth Annual Ethical Leadership Conference Panel Drivers, Challenges, and Strategies for Future, Academy of Management Review, Academy of Management Perspectives, Business & Society, Long Range Planning Social Responsibility for Hess Corporation, a global integrated energy company based in New York City

  6. Emergency vehicle driver training by Texas municipal police departments: a descriptive study

    E-Print Network [OSTI]

    Westmoreland, Robert Lawrence

    1994-01-01T23:59:59.000Z

    Because of the increase in the number of monetary civil judgments arising out of police emergency driving situations, law enforcement agencies are taking a critical look at their emergency driver training programs. At the present time...

  7. Summary of sessions B and F: High intensity linacs and frontend & proton drivers

    SciTech Connect (OSTI)

    Ferdinand, R.; /Saclay; Chou, W.; /Fermilab; Galambos, J.; /Oak Ridge

    2005-01-01T23:59:59.000Z

    This paper summarizes the sessions B&F of the 33rd ICFA Advanced Beam Dynamics Workshop on High Intensity & High Brightness Hadron Beams held in Bensheim, Germany. It covers high intensity linacs, front ends and proton driver topics.

  8. The physics issues that determine inertial confinement fusion target gain and driver requirements: A tutorial*

    E-Print Network [OSTI]

    with simple models for hohlraum wall energy loss to predict coupling efficiencies and a simple one into running the driver. More- over, the unrecycled portion of energy produced must be sufficient to sell

  9. Vehicle Technologies Office Merit Review 2014: Look-Ahead Driver Feedback and Powertrain Management

    Broader source: Energy.gov [DOE]

    Presentation given by Eaton at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about look-ahead driver feedback and...

  10. active-load laser driver: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: BGD 9, 14437-14473, 2012 Soil carbon drivers and benchmarks in Earth system models K. E. O. Todd if available. Causes of variation in soil carbon predictions from...

  11. Age and cross-cultural comparison of drivers' cognitive workload and performance in simulated urban driving

    E-Print Network [OSTI]

    Son, J.

    Driving demands significant psychomotor attention and requires even more when drivers are engaged in secondary tasks that increase cognitive workload and divert attention. It is well established that age influences driving ...

  12. Adaptacin de un driver WLAN Linux a una arquitectura NIOS-Avalon

    E-Print Network [OSTI]

    Autònoma de Barcelona, Universitat

    Adaptación de un driver WLAN Linux a una arquitectura NIOS-Avalon B. Martínez , I. Tarruella, D de un driver Linux se realiza un mapeo sobre una arquitectura basada en un procesador integrado dentro de un SoC. La elección de la partición Hw/Sw y de ciertos parámetros de la arquitectura se

  13. Review of a Spoke-Cavity Design Option for the RIA Driver Linac

    SciTech Connect (OSTI)

    Petr Ostroumov; Kenneth Shepard; Jean Delayen

    2005-05-16T23:59:59.000Z

    A design option for the 1.4 GV, multiple-charge-state driver linac required for the U. S. Rare Isotope Accelerator Project based on 345 MHz, 3-cell spoke-loaded cavities has been previously discussed [1]. This paper updates consideration of design options for the RIA driver, including recent results from numerically-modeling the multi-charge-state beam dynamics and also cold test results for prototype superconducting niobium 3-cell spoke-loaded cavities.

  14. STUDENT EMPLOYMENT Student Involvement Outcomes

    E-Print Network [OSTI]

    de Lijser, Peter

    STUDENT EMPLOYMENT Student Involvement Outcomes reflective assessment High impact practices. Employment Structure ASI employs approximately 645 staff, interns, and volunteers on average during the fall and spring semesters. In spring 2013, ASI employed: · 42 Interns · 59 Professional Staff Members · 162

  15. DRIVERS OF H I TURBULENCE IN DWARF GALAXIES

    SciTech Connect (OSTI)

    Stilp, Adrienne M.; Dalcanton, Julianne J. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Skillman, Evan [Minnesota Institute for Astrophysics, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455 (United States); Warren, Steven R. [Department of Astronomy, University of Maryland, CSS Building, Room 1024, Stadium Drive, College Park, MD 20742-2421 (United States); Ott, Juergen [National Radio Astronomy Observatory, P.O. Box O, 1003 Lopezville Road, Socorro, NM 87801 (United States); Koribalski, Baerbel [Australia Telescope National Facility, CSIRO Astronomy and Space Science, P.O. Box 76, Epping, NSW 1710 (Australia)

    2013-08-20T23:59:59.000Z

    Neutral hydrogen (H I) velocity dispersions are believed to be set by turbulence in the interstellar medium (ISM). Although turbulence is widely believed to be driven by star formation, recent studies have shown that this driving mechanism may not be dominant in regions of low star formation surface density ({Sigma}{sub SFR}), such those as found in dwarf galaxies or the outer regions of spirals. We have generated average H I line profiles in a number of nearby dwarfs and low-mass spirals by co-adding H I spectra in subregions with either a common radius or {Sigma}{sub SFR}. We find that the individual spatially resolved ''superprofiles'' are composed of a central narrow peak ({approx}5-15 km s{sup -1}) with higher velocity wings to either side, similar to their global counterparts as calculated for the galaxy as a whole. Under the assumption that the central peak reflects the H I turbulent velocity dispersion, we compare measures of H I kinematics determined from the superprofiles to local ISM properties, including surface mass densities and measures of star formation. The shape of the wings of the superprofiles do not show any correlation with local ISM properties, which indicates that they may be an intrinsic feature of H I line-of-sight spectra. On the other hand, the H I velocity dispersion is correlated most strongly with baryonic and H I surface mass density, which points toward a gravitational origin for turbulence, but it is unclear which, if any, gravitational instabilities are able to operate efficiently in these systems. Star formation energy is typically produced at a level sufficient to drive H I turbulent motions at realistic coupling efficiencies in regimes where {Sigma}{sub SFR} {approx}> 10{sup -4} M{sub Sun} yr{sup -1} kpc{sup -2}, as is typically found in inner spiral disks. At low star formation intensities, on the other hand, star formation cannot supply enough energy to drive the observed turbulence, nor does it uniquely determine the turbulent velocity dispersion. Nevertheless, even at low intensity, star formation does appear to provide a lower threshold for H I velocity dispersions. We find a pronounced decrease in coupling efficiency with increasing {Sigma}{sub SFR}, which would be consistent with a picture where star formation couples to the ISM with constant efficiency, but that less of that energy is found in the neutral phase at higher {Sigma}{sub SFR}. We have examined a number of potential drivers of H I turbulence, including star formation, gravitational instabilities, the magneto-rotational instability, and accretion-driven turbulence, and found that, individually, none of these drivers is capable of driving the observed levels of turbulence in the low {Sigma}{sub SFR} regime. We discuss possible solutions to this conundrum.

  16. EXTENDING THE USEFUL LIFE OF OLDER MASS SPECTROMETERS

    SciTech Connect (OSTI)

    Johnson, S.; Cordaro, J.; Holland, M.; Jones, V.

    2010-06-17T23:59:59.000Z

    Thermal ionization and gas mass spectrometers are widely used across the Department of Energy (DOE) Complex and contractor laboratories. These instruments support critical missions, where high reliability and low measurement uncertainty are essential. A growing number of these mass spectrometers are significantly older than their original design life. The reality is that manufacturers have declared many of the instrument models obsolete, with direct replacement parts and service no longer available. Some of these obsolete models do not have a next generation, commercially available replacement. Today's budget conscious economy demands for the use of creative funds management. Therefore, the ability to refurbish (or upgrade) these valuable analytical tools and extending their useful life is a cost effective option. The Savannah River Site (SRS) has the proven expertise to breathe new life into older mass spectrometers, at a significant cost savings compared to the purchase and installation of new instruments. A twenty-seven year old Finnigan MAT-261{trademark} Thermal Ionization Mass Spectrometer (TIMS), located at the SRS F/H Area Production Support Laboratory, has been successfully refurbished. Engineers from the Savannah River National Laboratory (SRNL) fabricated and installed the new electronics. These engineers also provide continued instrument maintenance services. With electronic component drawings being DOE Property, other DOE Complex laboratories have the option to extend the life of their aged Mass Spectrometers.

  17. Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

    E-Print Network [OSTI]

    von Mühlen, D.; Allison, M.; Jassal, S. K.; Barrett-Connor, E.

    2009-01-01T23:59:59.000Z

    calcification and the risk of osteoporosis and fractures. Jarterial disease and osteoporosis in older adults: theassociation between PAD and osteoporosis and bone loss only

  18. Large Synoptic Survey Telescope: From Science Drivers to Reference Design

    SciTech Connect (OSTI)

    Ivezic, Z.; Axelrod, T.; Brandt, W.N.; Burke, D.L.; Claver, C.F.; Connolly, A.; Cook, K.H.; Gee, P.; Gilmore, D.K.; Jacoby, S.H.; Jones, R.L.; Kahn, S.M.; Kantor, J.P.; Krabbendam, V.; Lupton, R.H.; Monet, D.G.; Pinto, P.A.; Saha, A.; Schalk, T.L.; Schneider, D.P.; Strauss, Michael A.; /Washington U., Seattle, Astron. Dept. /LSST Corp. /Penn State U., Astron. Astrophys. /KIPAC, Menlo Park /NOAO, Tucson /LLNL, Livermore /UC, Davis /Princeton U., Astrophys. Sci. Dept. /Naval Observ., Flagstaff /Arizona U., Astron. Dept. - Steward Observ. /UC, Santa Cruz /Harvard U. /Johns Hopkins U. /Illinois U., Urbana

    2011-10-14T23:59:59.000Z

    In the history of astronomy, major advances in our understanding of the Universe have come from dramatic improvements in our ability to accurately measure astronomical quantities. Aided by rapid progress in information technology, current sky surveys are changing the way we view and study the Universe. Next-generation surveys will maintain this revolutionary progress. We focus here on the most ambitious survey currently planned in the visible band, the Large Synoptic Survey Telescope (LSST). LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: constraining dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. It will be a large, wide-field ground-based system designed to obtain multiple images covering the sky that is visible from Cerro Pachon in Northern Chile. The current baseline design, with an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg{sup 2} field of view, and a 3,200 Megapixel camera, will allow about 10,000 square degrees of sky to be covered using pairs of 15-second exposures in two photometric bands every three nights on average. The system is designed to yield high image quality, as well as superb astrometric and photometric accuracy. The survey area will include 30,000 deg{sup 2} with {delta} < +34.5{sup o}, and will be imaged multiple times in six bands, ugrizy, covering the wavelength range 320-1050 nm. About 90% of the observing time will be devoted to a deep-wide-fast survey mode which will observe a 20,000 deg{sup 2} region about 1000 times in the six bands during the anticipated 10 years of operation. These data will result in databases including 10 billion galaxies and a similar number of stars, and will serve the majority of science programs. The remaining 10% of the observing time will be allocated to special programs such as Very Deep and Very Fast time domain surveys. We describe how the LSST science drivers led to these choices of system parameters.

  19. The Geant4 Visualisation System - a multi-driver graphics system

    E-Print Network [OSTI]

    John Allison; Laurent Garnier; Akinori Kimura; Joseph Perl

    2012-12-31T23:59:59.000Z

    From the beginning the Geant4 Visualisation System was designed to support several simultaneous graphics systems written to common abstract interfaces. Today it has matured into a powerful diagnostic and presentational tool. It comes with a library of models that may be added to the current scene and which include the representation of the Geant4 geometry hierarchy, simulated trajectories and user-written hits and digitisations. The workhorse is the OpenGL suite of drivers for X, Xm, Qt and Win32. There is an Open Inventor driver. Scenes can be exported in special graphics formats for offline viewing in the DAWN, VRML, HepRApp and gMocren browsers. PostScript can be generated through OpenGL, Open Inventor, DAWN and HepRApp. Geant4's own tracking algorithms are used by the Ray Tracer. Not all drivers support all features but all drivers bring added functionality of some sort. This paper describes the interfaces and details the individual drivers.

  20. Critical Drivers for Safety Culture: Examining Department of Energy and U.S. Army Operational Experiences - 12382

    SciTech Connect (OSTI)

    Lowes, Elizabeth A. [The S.M. Stoller Corporation, Broomfield, Colorado (United States)

    2012-07-01T23:59:59.000Z

    Evaluating operational incidents can provide a window into the drivers most critical to establishing and maintaining a strong safety culture, thereby minimizing the potential project risk associated with safety incidents. By examining U.S. Department of Energy (DOE) versus U.S. Army drivers in terms of regulatory and contract requirements, programs implemented to address the requirements, and example case studies of operational events, a view of the elements most critical to making a positive influence on safety culture is presented. Four case studies are used in this evaluation; two from DOE and two from U.S. Army experiences. Although the standards guiding operations at these facilities are different, there are many similarities in the level of hazards, as well as the causes and the potential consequences of the events presented. Two of the incidents examined, one from a DOE operation and the other from a U.S. Army facility, resulted in workers receiving chemical burns. The remaining two incidents are similar in that significant conduct of operations failures occurred resulting in high-level radioactive waste (in the case of the DOE facility) or chemical agent (in the case of the Army facility) being transferred outside of engineering controls. A review of the investigation reports for all four events indicates the primary causes to be failures in work planning leading to ineffective hazard evaluation and control, lack of procedure adherence, and most importantly, lack of management oversight to effectively reinforce expectations for safe work planning and execution. DOE and Army safety programs are similar, and although there are some differences in contractual requirements, the expectations for safe performance are essentially the same. This analysis concludes that instilling a positive safety culture comes down to management leadership and engagement to (1) cultivate an environment that values a questioning attitude and (2) continually reinforce expectations for the appropriate level of rigor in work planning and procedure adherence. A review of the root causes and key contributing causes to the events indicate: - Three of the four root cause analyses cite lack of management engagement (oversight, involvement, ability to recognize issues, etc.) as a root cause to the events. - Two of the four root cause analyses cite work planning failures as a root cause to the events and all cause analyses reflect work planning failures as contributing factors to the events. - All events with the exception of the Tuba City plant shutdown indicate procedure noncompliance as a key contributor; in the case of Tuba City the procedure issues were primarily related to a lack of procedures, or a lack of sufficiently detailed procedures. - All events included discussion or suggestion of a lack of a questioning attitude, either on the part of management/supervision, work planners, or workers. This analysis suggests that the most critical drivers to safety culture are: - Management engagement, - Effective work planning and procedures, and - Procedure adherence with a questioning attitude to ensure procedural problems are identified and fixed. In high-hazard operational environments the importance of robust work planning processes and procedure adherence cannot be overstated. However, having the processes by themselves is not enough. Management must actively engage in expectation setting and ensure work planning that meets expectations for hazard analysis and control, develop a culture that encourages incident reporting and a questioning attitude, and routinely observe work performance to reinforce expectations for adherence to procedures/work control documents. In conclusion, the most critical driver to achieving a workforce culture that supports safe and effective project performance can be summarized as follows: 'Management engagement to continually reinforce expectations for work planning processes and procedure adherence in an environment that cultivates a questioning attitude'. (authors)

  1. Older-first Garbage Collection in Practice: Evaluation in a Java Virtual Machine,

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Older-first Garbage Collection in Practice: Evaluation in a Java Virtual Machine, Darko Stefanovid performing copying garbage collectorsused a generational policy which repeatedly collects the very youngest. A previous study that used garbage- collection simulation pointed to potential improvements by using an Older

  2. Grid Parity for Residential Photovoltaics in the United States: Key Drivers and Sensitivities; Preprint

    SciTech Connect (OSTI)

    Ong, S.; Denholm, P.; Clark, N.

    2012-08-01T23:59:59.000Z

    In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that electricity price rather than technical parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  3. CarSafe: A Driver Safety App that Detects Dangerous Driving Behavior using Dual-Cameras on Smartphones

    E-Print Network [OSTI]

    Campbell, Andrew T.

    CarSafe: A Driver Safety App that Detects Dangerous Driving Behavior using Dual}@cs.dartmouth.edu ABSTRACT Driving while being tired or distracted is dangerous. We are developing the CafeSafe app on the phone to detect and alert drivers to dangerous driving conditions inside and outside the car. Car

  4. 1 Managed by UT-Battelle for the U.S. Department of Energy Global and regional drivers of

    E-Print Network [OSTI]

    1 Managed by UT-Battelle for the U.S. Department of Energy Global and regional drivers to climate change #12;2 Managed by UT-Battelle for the U.S. Department of Energy Global and regional drivers

  5. Abstract--There are two types of drivers in production machine systems: constant velocity (CV) motor and servo-motor.

    E-Print Network [OSTI]

    Zhang, WJ "Chris"

    ) motor and servo-motor. If a system contains two drivers or more, among which some are of the CV motor while the other are the servo-motor, the system has the so-called hybrid driver architecture is stable. A simulation is performed to show verify the proposed controller. The CV motor has the velocity

  6. Fact #845: November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in Operation has Increased – Dataset

    Broader source: Energy.gov [DOE]

    Excel file with dataset for Fact #845: From 1970 to 2013 the Share of Older Vehicles in Operation has Increased

  7. UA researchers develop develop a device for moving industrial vehicles without drivers

    E-Print Network [OSTI]

    Escolano, Francisco

    in settings with extreme human conditions (cold storage, waste management , etc....) The device is availableUA researchers develop develop a device for moving industrial vehicles without drivers Researchers Localization And Mapping). This technology is applicable to any business or industrial environment where

  8. Design and characterization of a signal insulation coreless transformer integrated in a CMOS gate driver chip

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Design and characterization of a signal insulation coreless transformer integrated in a CMOS gate the implementation of numerous distinct power transistor gate drivers, the control signal insulation is becoming more results will be shown in order to validate the functionality. I. INTRODUCTION An insulation system

  9. Stochastic Behaviour of the Electricity Bid Stack: from Fundamental Drivers to Power Prices

    E-Print Network [OSTI]

    Howison, Sam

    Stochastic Behaviour of the Electricity Bid Stack: from Fundamental Drivers to Power Prices Michael@maths.ox.ac.uk (01865 280613) Sam Howison Oxford-Man Institute, University of Oxford, Blue Boar Court, 9 Alfred Street on stochastic processes for underlying factors (fuel prices, power demand and generation capacity availability

  10. Refueling Behavior of Flexible Fuel Vehicle Drivers in the Federal Fleet

    SciTech Connect (OSTI)

    Daley, R.; Nangle, J.; Boeckman, G.; Miller, M.

    2014-05-01T23:59:59.000Z

    Federal fleets are a frequent subject of legislative and executive efforts to lead a national transition to alternative fuels and advanced vehicle technologies. Section 701 of the Energy Policy Act of 2005 requires that all dual-fueled alternative fuel vehicles in the federal fleet be operated on alternative fuel 100% of the time when they have access to it. However, in Fiscal Year (FY) 2012, drivers of federal flex fuel vehicles (FFV) leased through the General Services Administration refueled with E85 24% of the time when it was available--falling well short of the mandate. The U.S. Department of Energy's National Renewable Energy Laboratory completed a 2-year Laboratory Directed Research and Development project to identify the factors that influence the refueling behavior of federal FFV drivers. The project began with two primary hypotheses. First, information scarcity increases the tendency to miss opportunities to purchase E85. Second, even with perfect information, there are limits to how far drivers will go out of their way to purchase E85. This paper discusses the results of the project, which included a June 2012 survey of federal fleet drivers and an empirical analysis of actual refueling behavior from FY 2009 to 2012. This research will aid in the design and implementation of intervention programs aimed at increasing alternative fuel use and reducing petroleum consumption.

  11. A fuel economy optimization system with applications in vehicles with human drivers and autonomous vehicles

    E-Print Network [OSTI]

    Wu, Changxu (Sean)

    A fuel economy optimization system with applications in vehicles with human drivers and autonomous University of New York, Buffalo, USA a r t i c l e i n f o Keywords: Vehicle fuel economy Eco-driving Human developed and validated a new fuel-economy optimization system (FEOS), which receives input from vehicle

  12. IMPACT OF BEAM TRANSPORT METHOD ON CHAMBER AND DRIVER DESIGN FOR

    E-Print Network [OSTI]

    IMPACT OF BEAM TRANSPORT METHOD ON CHAMBER AND DRIVER DESIGN FOR HEAVY ION INERTIAL FUSION ENERGY D propagate in thick-liquid-wall, wetted-wall, and dry-wall chambers. KEYWORDS: heavy ion fusion, ion beam transport, reactor chamber design I. INTRODUCTION The U.S. heavy ion fusion ~HIF! program is working toward

  13. DRIVER ASSISTED CONTROL STRATEGIES: THEORY AND EXPERIMENT Mark DePoorter

    E-Print Network [OSTI]

    Brennan, Sean

    performance is specified as a Reference Model. The driver maintains nominal control of the vehicle by direct actuation of the front steering inputs. The controller then determines the appropriate rear steer inputs. An appropriate vehicle model is developed and a polynomial pole placement technique is used to control

  14. Megafauna biomass tradeoff as a driver of Quaternary and future extinctions

    E-Print Network [OSTI]

    California at Berkeley, University of

    Megafauna biomass tradeoff as a driver of Quaternary and future extinctions Anthony D. Barnosky,000 and 3,000 years ago. Estimates of megafauna biomass (including hu- mans as a megafauna species) for before, during, and after the extinction episode suggest that growth of human biomass largely matched

  15. Multimodal Presentation of Local Danger Warnings for Drivers: A Situation-Dependent Assessment of Usability

    E-Print Network [OSTI]

    Theune, Mariët

    Multimodal Presentation of Local Danger Warnings for Drivers: A Situation-Dependent Assessment danger warning function. To achieve high-quality assistance, the communication mode needs to be adaptive. Moreover, regardless of communication mode, the local danger warning function was considered as the most

  16. Hydrology as a driver of biodiversity: Controls on carrying capacity, niche formation, and dispersal

    E-Print Network [OSTI]

    Konar, Megan

    Hydrology as a driver of biodiversity: Controls on carrying capacity, niche formation Centre for Hydrology, ``Dino Tonini'', Padua, Italy a r t i c l e i n f o Article history: Available online 3 March 2012 Keywords: Hydrology Biodiversity Dispersal Carrying capacity Niches Climate change

  17. 2002-21-0041 Performance Driver Information Systems, Enhancing the Fun-to-Drive Equation

    E-Print Network [OSTI]

    in automobiles today display vehicle speed, fluid levels, fluid temperatures, and some basic diagnostic information (warnings, panel lamps). Optional driver information systems add to this list by offering fuel to be very complex. Essentially, all that is required is a speedometer and a fuel gauge. The speedometer

  18. A method for calibration of bone driver transducers to measure the mastoid Reggie Weece a

    E-Print Network [OSTI]

    Allen, Jont

    2010 Available online xxxx a b s t r a c t When using bone vibrator transducers for clinical a circuit model of the driver, describing it with three frequency-dependent parameters. Once these three circuit model is proposed to better capture the observed behaviors. Ã? 2010 Published by Elsevier B.V. 1

  19. Offshore Wind Turbine Design: Addressing Uncertainty Drivers Sten Frandsen Niels Jacob Tarp-Johansen

    E-Print Network [OSTI]

    the next generation of offshore wind farms are designed. The aim of this paper is to discuss existingOffshore Wind Turbine Design: Addressing Uncertainty Drivers Sten Frandsen Niels Jacob Tarp@civil.auc.dk leje@elsam-eng.com Abstract: Current offshore wind turbine design methods have matured to a 1st

  20. An investigation of driver behavior at highway-railroad grade crossings

    E-Print Network [OSTI]

    Shull, Lee Anne

    1996-01-01T23:59:59.000Z

    crossing results, in that the presence of a crossing (rather than the presence of a train) is indicated by the location of the crossbucks. The driver is ultimately responsible for achieving safe passage across a passive crossing because no warning devices...

  1. Young drivers and the efficacy of the Texas drug and alcohol driving awareness program

    E-Print Network [OSTI]

    Darnell, Richard

    2009-05-15T23:59:59.000Z

    The purpose of this study was to examine the efficacy of the Texas Drug and Alcohol Driving Awareness Program (TDADAP) in relation to alcohol-related offenses among young drivers. Participants in this study were students in pre-license programs...

  2. What kind of charging infrastructure do Chevrolet Volts Drivers in The EV Project use?

    SciTech Connect (OSTI)

    John Smart

    2013-09-01T23:59:59.000Z

    This report summarizes key conclusions from analysis of data collected from Chevrolet Volts participating in The EV Project. Topics include how much Volt drivers charge at level 1 vs. level 2 rates and how much they charge at home vs. away from home.

  3. Perception Drivers for Treated Wood by U.S. South Homebuilders and Remodelers

    E-Print Network [OSTI]

    Wu, Qinglin

    Perception Drivers for Treated Wood by U.S. South Homebuilders and Remodelers Sanna M. Kallioranta1 for the use of treated wood products in construction is considerable, especially in the U.S. South for termite protection and to mitigate moisture related decay. This research investigates the perception about treated

  4. Evolution styles: using architectural knowledge as an evolution driver Carlos E. Cuesta1

    E-Print Network [OSTI]

    Perry, Dewayne E.

    Evolution styles: using architectural knowledge as an evolution driver Carlos E. Cuesta1 , Elena+D, 02006, Albacete, Spain ABSTRACT Software evolution is an increasingly challenging and compelling concern software evolution is carried out, software architecture emerges as one of the cornerstones that should

  5. Evolution on a Restless Planet: Were Environmental Variability and Environmental Change Major Drivers of Human Evolution?

    E-Print Network [OSTI]

    Richerson, Peter J.

    223 7 Evolution on a Restless Planet: Were Environmental Variability and Environmental Change Major Drivers of Human Evolution? Peter J. Richerson, Robert L. Bettinger, and Robert Boyd 7.1 Introduction Two kinds of factors set the tempo and direction of organic and cultural evolution, those external to biotic

  6. Setup, tests and results for the ATLAS TileCal Read Out Driver production

    E-Print Network [OSTI]

    Valero, Alberto; Castillo, V; Cuenca, C; Ferrer, A; Fullana, E; González, V; Higón, E; Munar, A; Poveda, J; Ruiz-Martínez, A; Salvachúa, B; Sanchís, E; Solans, C; Soret, J; Torres, J; Valls, J A

    2007-01-01T23:59:59.000Z

    In this paper we describe the performance and test results of the production of the 38 ATLAS TileCal Read Out Drivers (RODs). We first describe the basic hardware specifications and firmware functionality of the modules, the test-bench setup used for production and the test procedure to qualify the boards. We then finally show and discuss the performance results.

  7. HIGH INTENSITY LINAC DRIVER FOR THE SPIRAL-2 PROJECT : DESIGN OF SUPERCONDUCTING 88 MHZ QUARTER WAVE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . For the high-energy section of the linac, a superconducting 88 MHz Quarter Wave Resonator (beta 0.12) has been WAVE RESONATORS (BETA 0.12), POWER COUPLERS AND CRYOMODULES T. Junquera, G. Olry, H. Saugnac, J Abstract A superconducting linac driver, delivering deuterons with an energy up to 40 MeV (5 mA) and heavy

  8. Using Vision-Based Driver Assistance to Augment Vehicular Ad-Hoc Network Communication

    E-Print Network [OSTI]

    Beauchemin, Steven S.

    a Vision-Based Driver Assistance (VBDA) system that monitors the environment surrounding the vehicle using in the surrounding environment. The concept of a CCWS has been introduced, studied and validated by a number adoption of the Wireless Access in Vehicular Environments (WAVE) set of standards in production vehicles

  9. Evaluation of older bay mud sediment from Richmond Harbor, California

    SciTech Connect (OSTI)

    Pinza, M.R.; Mayhew, H.L.; Word, J.Q.

    1996-09-01T23:59:59.000Z

    The older, bay mud (OBM) unit predates modem man and could act as a barrier to the downward transport of contaminants from the younger bay mud (YBM) because of its hard-packed consistency. However, its chemical and biological nature have not been well characterized. Battelle/Marine Sciences Laboratory (MSL) conducted three independent studies of OBM sediment in January 1993, January 1994, and October 1994. These studies evaluated potential chemical contamination and biological effects of OBM that could occur as a result of dredging and disposal activities. These evaluations were performed by conducting chemical analysis, solid-phase toxicity tests, suspended- particulate-phase (SPP) toxicity tests, and bioaccumulation tests on the OBM sediment. If the sediment chemistry and toxicity results showed no or minimal contamination and toxicological responses, then either the OBM could be left exposed in Richmond Harbor after dredging the YBM without leaving a source of contamination, or if the project depths necessitate, the OBM would be acceptable for disposal at an appropriate disposal site.

  10. Methane storms as a driver of Titan's dune orientation

    E-Print Network [OSTI]

    Charnay, Benjamin; Rafkin, Scot; Narteau, Clément; Lebonnois, Sébastien; Rodriguez, Sébastien; Pont, Sylvain Courrech du; Lucas, Antoine

    2015-01-01T23:59:59.000Z

    Titan's equatorial regions are covered by eastward propagating linear dunes. This direction is opposite to mean surface winds simulated by Global Climate Models (GCMs), which are oriented westward at these latitudes, similar to trade winds on Earth. Different hypotheses have been proposed to address this apparent contradiction, involving Saturn's gravitational tides, large scale topography or wind statistics, but none of them can explain a global eastward dune propagation in the equatorial band. Here we analyse the impact of equinoctial tropical methane storms developing in the superrotating atmosphere (i.e. the eastward winds at high altitude) on Titan's dune orientation. Using mesoscale simulations of convective methane clouds with a GCM wind profile featuring superrotation, we show that Titan's storms should produce fast eastward gust fronts above the surface. Such gusts dominate the aeolian transport, allowing dunes to extend eastward. This analysis therefore suggests a coupling between superrotation, tro...

  11. Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield.

    SciTech Connect (OSTI)

    Sharpe, Robin Arthur; Kingsep, Alexander S. (Kurchatov Institute, Moscow, Russia); Smith, David Lewis; Olson, Craig Lee; Ottinger, Paul F. (Naval Research Laboratory, Washington, DC); Schumer, Joseph Wade (Naval Research Laboratory, Washington, DC); Welch, Dale Robert (Voss Scientific, Albuquerque, NM); Kim, Alexander (High Currents Institute, Tomsk, Russia); Kulcinski, Gerald L. (University of Wisconsin, Madison, WI); Kammer, Daniel C. (University of Wisconsin, Madison, WI); Rose, David Vincent (Voss Scientific, Albuquerque, NM); Nedoseev, Sergei L. (Kurchatov Institute, Moscow, Russia); Pointon, Timothy David; Smirnov, Valentin P. (Kurchatov Institute, Moscow, Russia); Turgeon, Matthew C.; Kalinin, Yuri G. (Kurchatov Institute, Moscow, Russia); Bruner, Nichelle "Nicki" (Voss Scientific, Albuquerque, NM); Barkey, Mark E. (University of Alabama, Tuscaloosa, AL); Guthrie, Michael (University of Wisconsin, Madison, WI); Thoma, Carsten (Voss Scientific, Albuquerque, NM); Genoni, Tom C. (Voss Scientific, Albuquerque, NM); Langston, William L.; Fowler, William E.; Mazarakis, Michael Gerrassimos

    2007-01-01T23:59:59.000Z

    Z-Pinch Inertial Fusion Energy (Z-IFE) complements and extends the single-shot z-pinch fusion program on Z to a repetitive, high-yield, power plant scenario that can be used for the production of electricity, transmutation of nuclear waste, and hydrogen production, all with no CO{sub 2} production and no long-lived radioactive nuclear waste. The Z-IFE concept uses a Linear Transformer Driver (LTD) accelerator, and a Recyclable Transmission Line (RTL) to connect the LTD driver to a high-yield fusion target inside a thick-liquid-wall power plant chamber. Results of RTL and LTD research are reported here, that include: (1) The key physics issues for RTLs involve the power flow at the high linear current densities that occur near the target (up to 5 MA/cm). These issues include surface heating, melting, ablation, plasma formation, electron flow, magnetic insulation, conductivity changes, magnetic field diffusion changes, possible ion flow, and RTL mass motion. These issues are studied theoretically, computationally (with the ALEGRA and LSP codes), and will work at 5 MA/cm or higher, with anode-cathode gaps as small as 2 mm. (2) An RTL misalignment sensitivity study has been performed using a 3D circuit model. Results show very small load current variations for significant RTL misalignments. (3) The key structural issues for RTLs involve optimizing the RTL strength (varying shape, ribs, etc.) while minimizing the RTL mass. Optimization studies show RTL mass reductions by factors of three or more. (4) Fabrication and pressure testing of Z-PoP (Proof-of-Principle) size RTLs are successfully reported here. (5) Modeling of the effect of initial RTL imperfections on the buckling pressure has been performed. Results show that the curved RTL offers a much greater buckling pressure as well as less sensitivity to imperfections than three other RTL designs. (6) Repetitive operation of a 0.5 MA, 100 kV, 100 ns, LTD cavity with gas purging between shots and automated operation is demonstrated at the SNL Z-IFE LTD laboratory with rep-rates up to 10.3 seconds between shots (this is essentially at the goal of 10 seconds for Z-IFE). (7) A single LTD switch at Tomsk was fired repetitively every 12 seconds for 36,000 shots with no failures. (8) Five 1.0 MA, 100 kV, 100 ns, LTD cavities have been combined into a voltage adder configuration with a test load to successfully study the system operation. (9) The combination of multiple LTD coaxial lines into a tri-plate transmission line is examined. The 3D Quicksilver code is used to study the electron flow losses produced near the magnetic nulls that occur where coax LTD lines are added together. (10) Circuit model codes are used to model the complete power flow circuit with an inductive isolator cavity. (11) LTD architectures are presented for drivers for Z-IFE and high yield. A 60 MA LTD driver and a 90 MA LTD driver are proposed. Present results from all of these power flow studies validate the whole LTD/RTL concept for single-shot ICF high yield, and for repetitive-shot IFE.

  12. The influence of contagion information and behavior on older adolescents' perceptions of peers with chronic illness 

    E-Print Network [OSTI]

    Grizzle, Jonhenry Cordell

    2005-11-01T23:59:59.000Z

    To explore attributions about chronically ill peers, 545 older adolescents ages 17-26 read a short vignette describing a brief social encounter with a hypothetical peer suffering from a medical condition, and then responded ...

  13. Cognitive and neural correlates of memory retrieval in young and older adults

    E-Print Network [OSTI]

    O'Kane, Gail, 1965-

    2004-01-01T23:59:59.000Z

    (cont.) increased activity whenever recollection was attempted, independent of the level of recollection success. The results are consistent with the hypothesis that increased left-lateralized retrieval activity in older ...

  14. Seismic vulnerability of older reinforced concrete frame structures in Mid-America

    E-Print Network [OSTI]

    Beason, Lauren Rae

    2004-09-30T23:59:59.000Z

    This research quantifies the seismic vulnerability of older reinforced concrete frame structures located in Mid-America. After designing a representative three-story gravity load designed reinforced concrete frame structure, a nonlinear analytical...

  15. The influence of contagion information and behavior on older adolescents' perceptions of peers with chronic illness

    E-Print Network [OSTI]

    Grizzle, Jonhenry Cordell

    2005-11-01T23:59:59.000Z

    To explore attributions about chronically ill peers, 545 older adolescents ages 17-26 read a short vignette describing a brief social encounter with a hypothetical peer suffering from a medical condition, and then responded to a series...

  16. Recognition and decision to treat depression in older adults presenting at GP surgeries 

    E-Print Network [OSTI]

    Campbell, Alison

    2010-11-26T23:59:59.000Z

    Objectives: The population, globally and nationally, is ageing and the numbers of those over the age of 65 is increasing. Given this increase in numbers, it is important that the physical and mental health needs of older ...

  17. Retinal microvascular abnormalities and cognitive function in older people with type 2 diabetes 

    E-Print Network [OSTI]

    Ding, Jie

    2010-11-24T23:59:59.000Z

    The deleterious effects of Type 2 diabetes on the brain have been shown to result in a greater prevalence of age-associated cognitive impairment and an enhanced risk of age-related cognitive decline in older diabetic ...

  18. Tracking Reading: Dual Task Costs of Oral Reading for Young Versus Older Adults

    E-Print Network [OSTI]

    Kemper, Susan; Bontempo, Daniel; Schmalzried, RaLynn Cheri; McKedy, Whitney; Tagliaferri, Bruno; Kieweg, Doug

    2014-02-01T23:59:59.000Z

    A digital pursuit rotor was used to monitor oral reading costs by time-locking tracking performance to the auditory wave form produced as young and older adults were reading out short paragraphs. Multilevel modeling was ...

  19. Tracking Talking: Dual Task Costs of Planning and Producing Speech for Young versus Older Adults

    E-Print Network [OSTI]

    Kemper, Susan; Hoffman, Lesa; Schmalzried, RaLynn Cheri; Herman, Ruth; Kieweg, Doug

    2011-05-01T23:59:59.000Z

    A digital pursuit rotor was used to monitor speech planning and production costs by time-locking tracking performance to the auditory wave form produced as young and older adults were describing someone they admire. The ...

  20. A Corpus Analysis of Spoken Smart-Home Interactions with Older Users 

    E-Print Network [OSTI]

    Möller, Sebastian; Gödde, Florian; Wolters, Maria

    2008-01-01T23:59:59.000Z

    In this paper, we present the collection and analysis of a spoken dialogue corpus obtained from interactions of older and younger users with a smart-home system. Our aim is to identify the amount and the origin of linguistic ...

  1. Outcomes After Intensity-Modulated Versus Conformal Radiotherapy in Older Men With Nonmetastatic Prostate Cancer

    SciTech Connect (OSTI)

    Bekelman, Justin E., E-mail: bekelman@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA (United States); Mitra, Nandita [Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Efstathiou, Jason [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Liao Kaijun [Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA (United States); Sunderland, Robert; Yeboa, Deborah N. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Armstrong, Katrina [Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA (United States); Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA (United States); Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA (United States); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: There is little evidence comparing complications after intensity-modulated (IMRT) vs. three-dimensional conformal radiotherapy (CRT) for prostate cancer. The study objective was to test the hypothesis that IMRT, compared with CRT, is associated with a reduction in bowel, urinary, and erectile complications in elderly men with nonmetastatic prostate cancer. Methods and Materials: We undertook an observational cohort study using registry and administrative claims data from the SEER-Medicare database. We identified men aged 65 years or older diagnosed with nonmetastatic prostate cancer in the United States between 2002 and 2004 who received IMRT (n = 5,845) or CRT (n = 6,753). The primary outcome was a composite measure of bowel complications. Secondary outcomes were composite measures of urinary and erectile complications. We also examined specific subsets of bowel (proctitis/hemorrhage) and urinary (cystitis/hematuria) events within the composite complication measures. Results: IMRT was associated with reductions in composite bowel complications (24-month cumulative incidence 18.8% vs. 22.5%; hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.79-0.93) and proctitis/hemorrhage (HR 0.78; 95% CI, 0.64-0.95). IMRT was not associated with rates of composite urinary complications (HR 0.93; 95% CI, 0.83-1.04) or cystitis/hematuria (HR 0.94; 95% CI, 0.83-1.07). The incidence of erectile complications involving invasive procedures was low and did not differ significantly between groups, although IMRT was associated with an increase in new diagnoses of impotence (HR 1.27, 95% CI, 1.14-1.42). Conclusion: IMRT is associated with a small reduction in composite bowel complications and proctitis/hemorrhage compared with CRT in elderly men with nonmetastatic prostate cancer.

  2. An analysis of factors contributing to train-involved crashes

    E-Print Network [OSTI]

    Cooner, Scott Allen

    1995-01-01T23:59:59.000Z

    analyzed for the contributing factors. The contributing factors were classified into four categories: railroad factors, environmental factors, roadway factors, and driver/passenger factors. The accident data was analyzed using one and two-way classification...

  3. Ferroelectric opening switches for large-scale pulsed power drivers.

    SciTech Connect (OSTI)

    Brennecka, Geoffrey L.; Rudys, Joseph Matthew; Reed, Kim Warren; Pena, Gary Edward; Tuttle, Bruce Andrew; Glover, Steven Frank

    2009-11-01T23:59:59.000Z

    Fast electrical energy storage or Voltage-Driven Technology (VDT) has dominated fast, high-voltage pulsed power systems for the past six decades. Fast magnetic energy storage or Current-Driven Technology (CDT) is characterized by 10,000 X higher energy density than VDT and has a great number of other substantial advantages, but it has all but been neglected for all of these decades. The uniform explanation for neglect of CDT technology is invariably that the industry has never been able to make an effective opening switch, which is essential for the use of CDT. Most approaches to opening switches have involved plasma of one sort or another. On a large scale, gaseous plasmas have been used as a conductor to bridge the switch electrodes that provides an opening function when the current wave front propagates through to the output end of the plasma and fully magnetizes the plasma - this is called a Plasma Opening Switch (POS). Opening can be triggered in a POS using a magnetic field to push the plasma out of the A-K gap - this is called a Magnetically Controlled Plasma Opening Switch (MCPOS). On a small scale, depletion of electron plasmas in semiconductor devices is used to affect opening switch behavior, but these devices are relatively low voltage and low current compared to the hundreds of kilo-volts and tens of kilo-amperes of interest to pulsed power. This work is an investigation into an entirely new approach to opening switch technology that utilizes new materials in new ways. The new materials are Ferroelectrics and using them as an opening switch is a stark contrast to their traditional applications in optics and transducer applications. Emphasis is on use of high performance ferroelectrics with the objective of developing an opening switch that would be suitable for large scale pulsed power applications. Over the course of exploring this new ground, we have discovered new behaviors and properties of these materials that were here to fore unknown. Some of these unexpected discoveries have lead to new research directions to address challenges.

  4. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-01-01T23:59:59.000Z

    Hybrid electric vehicles, plug-in hybrid electric vehicles, and battery electric vehicles offer the potential to reduce both oil imports and greenhouse gases, as well as to offer a financial benefit to the driver. However, assessing these potential benefits is complicated by several factors, including the driving habits of the operator. We focus on driver aggression, i.e., the level of acceleration and velocity characteristic of travel, to (1) assess its variation within large, real-world drive datasets, (2) quantify its effect on both vehicle efficiency and economics for multiple vehicle types, (3) compare these results to those of standard drive cycles commonly used in the industry, and (4) create a representative drive cycle for future analyses where standard drive cycles are lacking.

  5. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles: Preprint

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-03-01T23:59:59.000Z

    Hybrid electric vehicles, plug-in hybrid electric vehicles, and battery electric vehicles offer the potential to reduce both oil imports and greenhouse gases, as well as to offer a financial benefit to the driver. However, assessing these potential benefits is complicated by several factors, including the driving habits of the operator. We focus on driver aggression, i.e., the level of acceleration and velocity characteristic of travel, to (1) assess its variation within large, real-world drive datasets, (2) quantify its effect on both vehicle efficiency and economics for multiple vehicle types, (3) compare these results to those of standard drive cycles commonly used in the industry, and (4) create a representative drive cycle for future analyses where standard drive cycles are lacking.

  6. OPERATION AND COMMISSIONING OF THE JEFFERSON LAB UV FEL USING AN SRF DRIVER ERL

    SciTech Connect (OSTI)

    R. Legg; S. Benson; G. Biallas; K. Blackburn; J. Boyce; D. Bullard; J. Coleman; C. Dickover; D. Douglas; F. Ellingsworth; P. Evtushenko; F. Hannon; C. Hernandez-Garcia; C. Gould; J. Gubeli; D. Hardy; K. Jordan; M. Klopf; J. Kortze; M. Marchlik; W. Moore; G. Neil; T. Powers; D. Sexton; Michelle D. Shinn; C. Tennant; R. Walker; G. Wilson

    2011-03-01T23:59:59.000Z

    We describe the operation and commissioning of the Jefferson Lab UV FEL using a CW SRF ERL driver. Based on the same 135 MeV linear accelerator as the Jefferson Lab 10 kW IR Upgrade FEL, the UV driver ERL uses a bypass geometry to provide transverse phase space control, bunch length compression, and nonlinear aberration compensation necessitating a unique set of commissioning and operational procedures. Additionally, a novel technique to initiate lasing is described. To meet these constraints and accommodate a challenging installation schedule, we adopted a staged commissioning plan with alternating installation and operation periods. This report addresses these issues and presents operational results from on-going beam operations.

  7. Managing the Drivers of Air Flow and Water Vapor Transport in Existing Single Family Homes (Revised)

    SciTech Connect (OSTI)

    Cummings, J.; Withers, C.; Martin, E.; Moyer, N.

    2012-10-01T23:59:59.000Z

    This document focuses on managing the driving forces which move air and moisture across the building envelope. While other previously published Measure Guidelines focus on elimination of air pathways, the ultimate goal of this Measure Guideline is to manage drivers which cause air flow and water vapor transport across the building envelope (and also within the home), control air infiltration, keep relative humidity (RH) within acceptable limits, avoid combustion safety problems, improve occupant comfort, and reduce house energy use.

  8. Evaluation of four selected servo hand controls for severely handicapped drivers

    E-Print Network [OSTI]

    Sexton, Donna Jean

    1979-01-01T23:59:59.000Z

    OF SCIENCE December 1979 Major Subject: Industrial Engineering EVALUATION OF FOUR SELECTED SERVO HAND CONTROLS FOR SEVERELY HANDICAPPED DRIVERS A Thesis by DONNA JEAN SEXTON Approved as to style and content by: (Co-Chairman of Committee) (Co... CURRENT TRENDS IN AUTOMOTIVE ADAPTIVE CONTROLS Mechanical Adaptive Controls Power Assist Adaptive Controls Joystick Controls METHOD Subjects The Tracking Task Apparatus DATA REDUCTION Analog to Digital Conversion Data Cleanup Calculation...

  9. Studies of a Linac Driver for a High Repetition Rate X-Ray FEL

    SciTech Connect (OSTI)

    Venturini, M.; Corlett, J.; Doolittle, L.; Filippetto, D.; Papadopoulos, C.; Penn, G.; Prosnitz, D.; Qiang, J.; Reinsch, M.; Ryne, R.; Sannibale, F.; Staples, J.; Wells, R.; Wurtele, J.; Zolotorev, M.; Zholents, A.

    2011-06-01T23:59:59.000Z

    We report on on-going studies of a superconducting CW linac driver intended to support a high repetition rate FEL operating in the soft x-rays spectrum. We present a pointdesign for a 1.8 GeV machine tuned for 300 pC bunches and delivering low-emittance, low-energy spread beams as needed for the SASE and seeded beamlines.

  10. DRIVER ACCELERATOR DESIGN FOR THE 10 KW UPGRADE OF THE JEFFERSON LAB IR FEL

    E-Print Network [OSTI]

    DRIVER ACCELERATOR DESIGN FOR THE 10 KW UPGRADE OF THE JEFFERSON LAB IR FEL D. Douglas, S. V, Newport News, VA23606, USA Abstract An upgrade of the Jefferson Lab IR FEL [1] is now un- der construction. It will provide 10 kW output light power in a wavelength range of 2­10 µm. The FEL will be driven by a modest

  11. Where do Nissan Leaf drivers in The EV Project charge when they have the opportunity to charge at work?

    SciTech Connect (OSTI)

    John Smart; Don Scoffield

    2014-03-01T23:59:59.000Z

    This paper invesigates where Nissan Leaf drivers in the EV Project charge when they have the opportunity to charge at work. Do they charge at work, home, or some other location?

  12. Where do Chevrolet Volt drivers in The EV Project charge when they have the opportunity to charge at work?

    SciTech Connect (OSTI)

    John Smart; Don Scoffield

    2014-03-01T23:59:59.000Z

    This paper investigates where Chevy Volt drivers in the EV Project charge when they have the opportunity to charge at work. Do they charge at home, work, or some other location.

  13. Analytic Framework for Evaluation of State Energy Efficiency and Renewable Energy Policies with Reference to Stakeholder Drivers

    SciTech Connect (OSTI)

    Brown, E.; Mosey, G.

    2008-07-01T23:59:59.000Z

    This report presents the framework that was developed to analyze energy efficiency and renewable energy policies on the state level based on how well they meet the stakeholder drivers.

  14. Compact, Intelligent, Digitally Controlled IGBT Gate Drivers for a PEBB-Based ILC Marx Modulator

    SciTech Connect (OSTI)

    Nguyen, M.N.; Burkhart, C.; Olsen, J.J.; Macken, K.; /SLAC; ,

    2010-06-07T23:59:59.000Z

    SLAC National Accelerator Laboratory has built and is currently operating a first generation prototype Marx klystron modulator to meet ILC specifications. Under development is a second generation prototype, aimed at improving overall performance, serviceability, and manufacturability as compared to its predecessor. It is designed around 32 cells, each operating at 3.75 kV and correcting for its own capacitor droop. Due to the uniqueness of this application, high voltage gate drivers needed to be developed for the main 6.5 kV and droop correction 1.7 kV IGBTs. The gate driver provides vital functions such as protection of the IGBT from over-voltage and over-current, detection of gate-emitter open and short circuit conditions, and monitoring of IGBT degradation (based on collector-emitter saturation voltage). Gate drive control, diagnostic processing capabilities, and communication are digitally implemented using an FPGA. This paper details the design of the gate driver circuitry, component selection, and construction layout. In addition, experimental results are included to illustrate the effectiveness of the protection circuit.

  15. Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01T23:59:59.000Z

    Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  16. Analysis of the Ultra-fast Switching Dynamics in a Hybrid MOSFET/Driver

    SciTech Connect (OSTI)

    Tang, T.; Burkhart, C.; /SLAC

    2011-08-17T23:59:59.000Z

    The turn-on dynamics of a power MOSFET during ultra-fast, {approx} ns, switching are discussed in this paper. The testing was performed using a custom hybrid MOSFET/Driver module, which was fabricated by directly assembling die-form components, power MOSFET and drivers, on a printed circuit board. By using die-form components, the hybrid approach substantially reduces parasitic inductance, which facilitates ultra-fast switching. The measured turn on time of the hybrid module with a resistive load is 1.2 ns with an applied voltage of 1000 V and drain current of 33 A. Detailed analysis of the switching waveforms reveals that switching behavior must be interpreted differently in the ultra-fast regime. For example, the gate threshold voltage to turn on the device is observed to increase as the switching time decreases. Further analysis and simulation of MOSFET switching behavior shows that the minimum turn on time scales with the product of the drain-source on resistance and drain-source capacitance, R{sub DS(on)}C{sub OSS}. This information will be useful in power MOSFET selection and gate driver design for ultra-fast switching applications.

  17. Survey of Laser Markets Relevant to Inertial Fusion Energy Drivers, information for National Research Council

    SciTech Connect (OSTI)

    Bayramian, A J; Deri, R J; Erlandson, A C

    2011-02-24T23:59:59.000Z

    Development of a new technology for commercial application can be significantly accelerated by leveraging related technologies used in other markets. Synergies across multiple application domains attract research and development (R and D) talent - widening the innovation pipeline - and increases the market demand in common components and subsystems to provide performance improvements and cost reductions. For these reasons, driver development plans for inertial fusion energy (IFE) should consider the non-fusion technology base that can be lveraged for application to IFE. At this time, two laser driver technologies are being proposed for IFE: solid-state lasers (SSLs) and KrF gas (excimer) lasers. This document provides a brief survey of organizations actively engaged in these technologies. This is intended to facilitate comparison of the opportunities for leveraging the larger technical community for IFE laser driver development. They have included tables that summarize the commercial organizations selling solid-state and KrF lasers, and a brief summary of organizations actively engaged in R and D on these technologies.

  18. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles (Presentation)

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-05-01T23:59:59.000Z

    This presentation discusses a method of accounting for realistic levels of driver aggression to higher-level vehicle studies, including the impact of variation in real-world driving characteristics (acceleration and speed) on vehicle energy consumption and different powertrains (e.g., conventionally powered vehicles versus electrified drive vehicles [xEVs]). Aggression variation between drivers can increase fuel consumption by more than 50% or decrease it by more than 20% from average. The normalized fuel consumption deviation from average as a function of population percentile was found to be largely insensitive to powertrain. However, the traits of ideal driving behavior are a function of powertrain. In conventional vehicles, kinetic losses dominate rolling resistance and aerodynamic losses. In xEVs with regenerative braking, rolling resistance and aerodynamic losses dominate. The relation of fuel consumption predicted from real-world drive data to that predicted by the industry-standard HWFET, UDDS, LA92, and US06 drive cycles was not consistent across powertrains, and varied broadly from the mean, median, and mode of real-world driving. A drive cycle synthesized by NREL's DRIVE tool accurately and consistently reproduces average real-world for multiple powertrains within 1%, and can be used to calculate the fuel consumption effects of varying levels of driver aggression.

  19. Use of the National Driver Register in the U.S. Department of Energy Human Reliability Program

    SciTech Connect (OSTI)

    Phillip M. Kannan, Center for Human Reliability Studies

    2007-01-01T23:59:59.000Z

    The National Driver Register (NDR) is a complex information network established and maintained by the Secretary of the Department of Transportation (DOT) under the National Driver Register Act of 1982. This report analyzes the question of whether information from the NDR is available to officials making Human Reliability Program (HRP) certification and recertification decisions and to Department of Energy (DOE) personnel security specialists making access authorization determinations.

  20. Studies involving low protein broiler diets

    E-Print Network [OSTI]

    Parkin, David Palmer

    1971-01-01T23:59:59.000Z

    STUDIES INVOLVING L(% PROTEIN BROILER DIETS A Thesis by David Palmer Parkin Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1971 Major Subject...: Poultry Science STUDIES INVOLVING LS& PROTEIN BROILER DIETS A Thesis by David Palmer Parkin Approved as to style and content by: (Chairman of Commit e) ead of. Departmen Me er) (Member) (Memb ) May 1971 ABSTRACT Studies Involving Low Protein...

  1. The Leadership and Involvement Record Sponsored by the Center for Leadership and Involvement

    E-Print Network [OSTI]

    Sheridan, Jennifer

    The Leadership and Involvement Record Sponsored by the Center for Leadership and Involvement The Leadership and Involvement Record is an official document from the University of Wisconsin recording the leadership roles, student org involvement, or group membership students have had on campus. The record

  2. Somatic complaints in older adults: aging process or symptoms of depression 

    E-Print Network [OSTI]

    Gentry, Ruth Anne

    2013-02-22T23:59:59.000Z

    LIST OF TABLES TABLE I Item Analysis for First Version of Older Adult Scale. . . PAGE 2 item Analysis for Second Version of Older Adult Scale. . . 15 3 Item Analysis for Geriatric Depression Scale. . . 16 4 Item Analysis for Beck Depression... you regret things that happened in the past? 26. Is your life interesting and enjoyable? 27. Do you feet lonely? 28. Is it hard for you to get going? 29. Do most people like you? 30. Do you have positive outlook? . 55 . 51 . 33 . 56 . 35...

  3. The role of the cant and lateral position of the steering wheel in the orientation of drivers to the location of the automotive pedals

    E-Print Network [OSTI]

    Sherrod, M. G

    1989-01-01T23:59:59.000Z

    examined the effects of three steering wheel cants and three steering wheel lateral positions on drivers' preferred automotive foot pedal locations and separation distances. The dependent variables were the preferred vertical and horizontal positions... in orienting the driver to the locations of the pedals and should be part of any design recommendations detailing the relationship between the driver and the foot pedals. ACKNOWLEDGEMENTS I would like to thank the chairman of my Advisory Committee, Dr...

  4. Battery Electric Vehicles: Range Optimization and Diversification for the U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong [ORNL] [ORNL

    2012-01-01T23:59:59.000Z

    Properly selecting the driving range is critical for accurately predicting the market acceptance and the resulting social benefits of BEVs. Analysis of transportation technology transition could be biased against battery electric vehicles (BEV) and mislead policy making, if BEVs are not represented with optimal ranges. This study proposes a coherent method to optimize the BEV driving range by minimizing the range-related cost, which is formulated as a function of range, battery cost, energy prices, charging frequency, access to backup vehicles, and the cost and refueling hassle of operating the backup vehicle. This method is implemented with a sample of 36,664 drivers, representing U.S. new car drivers, based on the 2009 National Household Travel Survey data. Key findings are: 1) Assuming the near term (2015) battery cost at $405/kWh, about 98% of the sampled drivers are predicted to prefer a range below 200 miles, and about 70% below 100 miles. The most popular 20-mile band of range is 57 to77 miles, unsurprisingly encompassing the Leaf s EPA-certified 73-mile range. With range limited to 4 or 7 discrete options, the majority are predicted to choose a range below 100 miles. 2) Found as a statistically robust rule of thumb, the BEV optimal range is approximately 0.6% of one s annual driving distance. 3) Reducing battery costs could motivate demand for larger range, but improving public charging may cause the opposite. 4) Using a single range to represent BEVs in analysis could significantly underestimate their competitiveness e.g. by $3226/vehicle if BEVs are represented with 73-mile range only or by $7404/BEV if with 150-mile range only. Range optimization and diversification into 4 or 7 range options reduce such analytical bias by 78% or 90%, respectively.

  5. Graphic Designer Student Involvement and Leadership

    E-Print Network [OSTI]

    Subramanian, Venkat

    Graphic Designer Student Involvement and Leadership Position Overview The Graphic Designer standards of the Student Involvement and Leadership brand guardrails · Complete other duties as assigned-Design, and Illustrator · Must have experience creating print and web graphics, flyers, and other promotional materials

  6. Charged particle driver for ICF using an accelerated, focused compact torus

    SciTech Connect (OSTI)

    Meeker, D.J.; Hammer, J.H.; Hartman, C.W.

    1986-06-01T23:59:59.000Z

    We report the status of evaluating an accelerated and focused compact torus as a driver for ICF. We are studying the acceleration and focusing aspects experimentally in the RACE facility, a recently completed ring generator coupled to a 260 kJ acceleration bank. Compact torus and ICF target interaction is being investigated with PIC codes and LASNEX, a 2D magneto-hydrodynamics code. Final conditions required of the CT are discussed as well as coupling issues such as superthermal electron production. We conclude with an economic evaluation of a few 100 MW reactor driven by a compact torus. 9 refs., 5 figs., 1 tab.

  7. What are the main drivers of the Bitcoin price? Evidence from wavelet coherence analysis

    E-Print Network [OSTI]

    Kristoufek, Ladislav

    2014-01-01T23:59:59.000Z

    Bitcoin has emerged as a fascinating phenomenon of the financial markets. Without any central authority issuing the currency, it has been associated with controversy ever since its popularity and public interest reached high levels. Here, we contribute to the discussion by examining potential drivers of Bitcoin prices ranging from fundamental to speculative and technical sources as well as a potential influence of the Chinese market. The evolution of the relationships is examined in both time and frequency domains utilizing the continuous wavelets framework so that we comment on development of the interconnections in time but we can also distinguish between short-term and long-term connections.

  8. Shaping the output pulse of a linear-transformer-driver module.

    SciTech Connect (OSTI)

    Long, Finis W.; McKee, G. Randall; Stoltzfus, Brian Scott; Woodworth, Joseph Ray; McKenney, John Lee; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John L.; Stygar, William A.; Savage, Mark Edward; LeChien, Keith, R.; Van De Valde, David M. (EG& G, Albuquerque, NM)

    2008-11-01T23:59:59.000Z

    We demonstrate that a wide variety of current-pulse shapes can be generated using a linear-transformer-driver (LTD) module that drives an internal water-insulated transmission line. The shapes are produced by varying the timing and initial charge voltage of each of the module's cavities. The LTD-driven accelerator architecture outlined in [Phys. Rev. ST Accel. Beams 10, 030401 (2007)] provides additional pulse-shaping flexibility by allowing the modules that drive the accelerator to be triggered at different times. The module output pulses would be combined and symmetrized by water-insulated radial-transmission-line impedance transformers [Phys. Rev. ST Accel. Beams 11, 030401 (2008)].

  9. Low-jitter high-power thyristor array pulse driver and generator

    DOE Patents [OSTI]

    Hanks, Roy L. (Byron, CA)

    2002-01-01T23:59:59.000Z

    A method and apparatus for generating low-jitter, high-voltage and high-current pulses for driving low impedance loads such as detonator fuses uses a MOSFET driver which, when triggered, discharges a high-voltage pre-charged capacitor into the primary of a toroidal current-multiplying transformer with multiple isolated secondary windings. The secondary outputs are suitable for driving an array of thyristors that discharge a precharged high-voltage capacitor and thus generating the required high-voltage and high-current pulse.

  10. Linear beam raster magnet driver based on H-bridge technique

    DOE Patents [OSTI]

    Sinkine, Nikolai I.; Yan, Chen; Apeldoorn, Cornelis; Dail, Jeffrey Glenn; Wojcik, Randolph Frank; Gunning, William

    2006-06-06T23:59:59.000Z

    An improved raster magnet driver for a linear particle beam is based on an H-bridge technique. Four branches of power HEXFETs form a two-by-two switch. Switching the HEXFETs in a predetermined order and at the right frequency produces a triangular current waveform. An H-bridge controller controls switching sequence and timing. The magnetic field of the coil follows the shape of the waveform and thus steers the beam using a triangular rather than a sinusoidal waveform. The system produces a raster pattern having a highly uniform raster density distribution, eliminates target heating from non-uniform raster density distributions, and produces higher levels of beam current.

  11. Data acquisition with a VAX 11/780 and MBD branch driver

    SciTech Connect (OSTI)

    King, S.E. (Duke Univ., Durham, NC); Lau, Y.C.; Gould, C.R.

    1981-10-01T23:59:59.000Z

    We have designed and implemented a general purpose data acquisition system, XSYS, for the Triangle Universities Nuclear Laboratory VAX-11/780. The interface is a CAMAC Branch Highway connected to a Microprogrammed Branch Driver (MBD-11). A single general reentrant MBD program handles CAMAC operations and data transfers to and from the VAX using a DMA transfer. Each of the eight MBD channels is controlled by an independent subprocess in the VAX which communicates with the MBD via the UNIBUS. Data are double buffered and are sorted by VAX user written EVAL codes after the MBD wakes a hibernating subprocess image. Scalar operations and control of external devices are also supported.

  12. Overview of proton drivers for neutrino super beams and neutrino factories

    SciTech Connect (OSTI)

    Chou, W.; /Fermilab

    2006-06-01T23:59:59.000Z

    There has been a world-wide interest in Proton Drivers in the past decade. Numerous design proposals have been presented in Asia, Europe and North America, ranging from low energy rapid cycling synchrotrons, normal or superconducting linacs to high energy slow cycling synchrotrons and FFAGs. One thing in common is that all these machines provide MW beam power and are used primarily for neutrino experiments. This paper gives an overview of these activities. In the last section the author expresses his personal opinion on the future of this field.

  13. Supplement Table 1. Mean environmental drivers at Brasil flux sites. Precipitation (Prec) from Tropical Rainfall Measuring Mission (TRMM), for site-specific tower measurement years and a

    E-Print Network [OSTI]

    Malhi, Yadvinder

    Supplement Table 1. Mean environmental drivers at Brasil flux sites. Precipitation (Prec) from #12;Supplement Table 2. Brasil flux sites instrumentation and measuring methods. *: non aspirated

  14. Use of seal-like robot PARO in sensory group therapy for older adults with dementia

    E-Print Network [OSTI]

    Sabanovic, Selma

    Use of seal-like robot PARO in sensory group therapy for older adults with dementia Wan-Ling Chang--This work presents the preliminary results of an eight- week study of the seal-like robot PARO being used adapted the concept of MSBT to the use of PARO as a multimodal sensory stimulus in a group activity

  15. at-risk older people: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at-risk older people First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 CONSIDERATIONS IN DESIGNING GAMES...

  16. This is how many older American workers today feel--trapped in a

    E-Print Network [OSTI]

    Neimark, Alexander V.

    . In a series of Work Trends surveys by the Heldrich Center for Workforce Development of workers who were laid will be permanently higher joblessness and a far less secure retire- ment--leading many workers over 50 to rethink periods of unemployment insurance have provided a temporary safety net for some older workers

  17. Life Exposures to Traumatic Events and Chronic Strains Among Older Mexican-Origin Individuals

    E-Print Network [OSTI]

    Garcia, Marc

    2012-10-19T23:59:59.000Z

    affects the physical health outcomes of Latinos. This thesis examines the extent to which traumatic life events and chronic strains affect the physical health outcomes of foreign-born and native-born Mexican-origin individuals (age 45 an older) residing...

  18. Are ightless Galapaganus weevils older than the Galapagos Islands they inhabit?

    E-Print Network [OSTI]

    Farrell, Brian D.

    are the Canary Islands (Thorpe et al., 1994; Juan et al., 1995, 1996) the Gala pagos Islands (Darwin, 1859Are ¯ightless Galapaganus weevils older than the GalaÂpagos Islands they inhabit? ANDREA S and include 10 ¯ightless species endemic to the Gala pagos islands. These beetles thus provide a promising

  19. Running head: STEREOTYPE THREAT REDUCES MEMORY ERRORS Stereotype threat can reduce older adults' memory errors

    E-Print Network [OSTI]

    Mather, Mara

    Running head: STEREOTYPE THREAT REDUCES MEMORY ERRORS Stereotype threat can reduce older adults, 90089-0191. Phone: 213-740-6772. Email: barbersa@usc.edu #12;STEREOTYPE THREAT REDUCES MEMORY ERRORS 2 Abstract (144 words) Stereotype threat often incurs the cost of reducing the amount of information

  20. Trust in the Health Care System and the Use of Preventive Health Services by Older Black

    E-Print Network [OSTI]

    Sheikh, Yaser Ajmal

    Trust in the Health Care System and the Use of Preventive Health Services by Older Black and White. Thomas, PhD There is strong empirical evidence of health care disparities between Black and White preventive care.1­5 The causes of disparities in health care are complex and have been the subject

  1. SS-166-99-R06 Diabetes and the Older Adult

    E-Print Network [OSTI]

    SS-166-99-R06 Diabetes and the Older Adult Approximately 18 million people (over 6% of the population) in the United States have diabetes. Another 16 million people have pre-diabetes, mean- ing that their blood glucose levels are higher than normal. It is estimated that 1 in 10 people will develop diabetes

  2. Plasma properties of driver gas following interplanetary shocks observed by ISEE-3

    SciTech Connect (OSTI)

    Zwickl, R.D.; Asbridge, J.R.; Bame, S.J.; Feldman, W.C.; Gosling, J.T.; Smith, E.J.

    1982-01-01T23:59:59.000Z

    Plasma fluid parameters calculated from solar wind and magnetic field data obtained on ISEE 3 were studied to determine the characteristic properties of driver gas following interplanetary shocks. Of 54 shocks observed from August 1978 to February 1980, 9 contained a well defined driver gas that was clearly identifiable by a discontinuous decrease in the average proton temperature across a tangential discontinuity. While helium enhancements were present in all of 9 of these events, only about half of them contained simultaneous changes in the two quantities. Often the He/H ratio changed over a period of minutes. Simultaneous with the drop in proton temperature the helium and electron temperature decreased abruptly. In some cases the proton temperature depression was accompanied by a moderate increase in magnetic field magnitude with an unusually low variance and by an increase in the ratio of parallel to perpendicular temperature. The drive gas usually displayed a bi-directional flow of suprathermal solar wind electrons at higher energies (>137 eV).

  3. Breakeven Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities (Report Summary) (Presentation)

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01T23:59:59.000Z

    "Break-even cost" for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this presentation, we introduce an analysis of PV break-even costs for residential customers in the United States, including an evaluation of some of the key drivers of PV breakeven both regionally and over time. This presentation includes our methodology and presents results for both near-term residential breakeven costs(2009) and future market sensitivities of break-even costs (2015). See also the the report "Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities". Presentation for NREL/TP-6A2-45991.

  4. Optimizing and Diversifying Electric Vehicle Driving Range for U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong [ORNL

    2014-01-01T23:59:59.000Z

    Properly determining the driving range is critical for accurately predicting the sales and social benefits of battery electric vehicles (BEVs). This study proposes a framework for optimizing the driving range by minimizing the sum of battery price, electricity cost, and range limitation cost referred to as the range-related cost as a measurement of range anxiety. The objective function is linked to policy-relevant parameters, including battery cost and price markup, battery utilization, charging infrastructure availability, vehicle efficiency, electricity and gasoline prices, household vehicle ownership, daily driving patterns, discount rate, and perceived vehicle lifetime. Qualitative discussion of the framework and its empirical application to a sample (N=36,664) representing new car drivers in the United States is included. The quantitative results strongly suggest that ranges of less than 100 miles are likely to be more popular in the BEV market for a long period of time. The average optimal range among U.S. drivers is found to be largely inelastic. Still, battery cost reduction significantly drives BEV demand toward longer ranges, whereas improvement in the charging infrastructure is found to significantly drive BEV demand toward shorter ranges. The bias of a single-range assumption and the effects of range optimization and diversification in reducing such biases are both found to be significant.

  5. A thirty-two clock hour driver education classroom curriculum guide

    E-Print Network [OSTI]

    Richardson, William Lee

    1990-01-01T23:59:59.000Z

    A THIRTY-TWO CLOCK HOUR DRIVER EDUCATION CLASSROOM CURRICULUM GUIDE A R e c o r d o f St u d y by WILLIAM LEE RICHARDSON S u b m i t t e d t o t h e O f f i c e o f G r a d u a t e S t u d i e s o f Texas A&M U n i v e r s i t y i n p a r t i... a l f u l f i l l m e n t o f t h e r e q u i r e m e n t s f o r t h e de g r e e o f DOCTOR OF EDUCATION December 1990 M a j o r S u b j e c t : I n d u s t r i a l E d u c a t i o n A THIRTY-TWO CLOCK HOUR DRIVER EDUCATION CLASSROOM...

  6. Review: Balancing Limiting Factors and Economic Drivers to Achieve Sustainable Midwestern US Agricultural Residue Feedstock Supplies

    SciTech Connect (OSTI)

    Wally W. Wilhelm; J. Richard Hess; Douglas L. Karlen; David J. Muth; Jane M. F. Johnson; John M. Baker; Hero T. Gollany; Jeff M. Novak; Diane E. Stott; Gary E. Varvel

    2010-10-01T23:59:59.000Z

    Advanced biofuels will be developed using cellulosic feedstock rather than grain or oilseed crops that can also be used for food and feed. To be sustainable, these new agronomic production systems must be economically viable without degrading soil resources. This review examines six agronomic factors that collectively define many of the limits and opportunities for harvesting crop residue for biofuel feedstock. These six “limiting factors” are discussed in relationship to economic drivers associated with harvesting corn (Zea mays L.) stover as a potential cellulosic feedstock. The limiting factors include soil organic carbon, wind and water erosion, plant nutrient balance, soil water and temperature dynamics, soil compaction, and off-site environmental impacts. Initial evaluations using the Revised Universal Soil Loss Equation 2.0 (RUSLE2) show that a single factor analysis based on simply meeting tolerable soil loss might indicate stover could be harvested sustainably, but the same analysis based on maintaining soil organic carbon shows the practice to be non-sustainable. Modifying agricultural management to include either annual or perennial cover crops is shown to meet both soil erosion and soil carbon requirements. The importance of achieving high yields and planning in a holistic manner at the landscape scale are also shown to be crucial for balancing limitations and drivers associated with renewable bioenergy production.

  7. A thirty-two clock hour driver education classroom curriculum guide 

    E-Print Network [OSTI]

    Richardson, William Lee

    1990-01-01T23:59:59.000Z

    A THIRTY-TWO CLOCK HOUR DRIVER EDUCATION CLASSROOM CURRICULUM GUIDE A R e c o r d o f St u d y by WILLIAM LEE RICHARDSON S u b m i t t e d t o t h e O f f i c e o f G r a d u a t e S t u d i e s o f Texas A&M U n i v e r s i t y i n p a r t i... a l f u l f i l l m e n t o f t h e r e q u i r e m e n t s f o r t h e de g r e e o f DOCTOR OF EDUCATION December 1990 M a j o r S u b j e c t : I n d u s t r i a l E d u c a t i o n A THIRTY-TWO CLOCK HOUR DRIVER EDUCATION CLASSROOM...

  8. Factors Involved in Search Dog Training

    E-Print Network [OSTI]

    Alexander, Michael B.

    2010-07-14T23:59:59.000Z

    involved in training competent search dogs. Obedience training methods, age training was initiated, previous handler canine training experience, and handler perception and emotional attachment to their search dog were examined through a sixty-six question...

  9. GM Project G.6 October 20008 -1 8. FATAL CRASH RATES

    E-Print Network [OSTI]

    GM Project G.6 October 20008 - 1 8. FATAL CRASH RATES 8.1 MODELING FATALITY RATES FOR OLDER DRIVERS crash rate concepts we call "driver risk,"or the driver fatality rate. It is the fatality rate, per mile driver. The driver fatality risk rate is measured by dividing the number of older drivers in a given age

  10. COMMUNITY INVOLVEMENT PLAN APRIL 15, 1999.

    SciTech Connect (OSTI)

    GEIGER,K.

    1999-04-15T23:59:59.000Z

    This Community Involvement Plan has been prepared by the Brookhaven National Laboratory's Community Involvement Office with the input of the community, Laboratory employees and representatives of the U.S. Department of Energy. The process to develop the plan began with the formation of a focus group consisting of representatives from: the community at large; special interest groups within the community; the business community; Laboratory retirees; senior and line management from the Laboratory; and the U.S. Department of Energy. The focus group reviewed an initial outline developed by the Office of Community involvement, held in-depth roundtable discussions of community involvement needs, and created a draft plan based on their discussions. A workshop was held to present the draft Community Involvement Plan to a wider audience for their input and insights on how Brookhaven should involve the community in decision making. This workshop was advertised in local newspapers and within the Laboratory. It was attended by community members, special interest group representatives, Laboratory employees and managers, U.S. Department of Energy-Brookhaven Group management, and members of the Laboratory's Community Advisory Council. The results of the workshop discussions are incorporated in this plan.

  11. Authorization and Driving History Form The following information will be retained on file by all agencies on their drivers authorized to operate a

    E-Print Network [OSTI]

    Harms, Kyle E.

    agencies on their drivers authorized to operate a State vehicle, or a private vehicle for state purposes ___________________________________________ Position: Staff_____ Faculty_____ Student_____ Is employee's primary purpose to drive vehicles? Yes_____ No/her private vehicle in the course and scope of employment? Yes_____ No_____ Date of last Driver Training

  12. Threat Assessment Design for Driver Assistance System at Intersections Georges S. Aoude, Brandon D. Luders, Kenneth K. H. Lee, Daniel S. Levine, and Jonathan P. How

    E-Print Network [OSTI]

    How, Jonathan P.

    Threat Assessment Design for Driver Assistance System at Intersections Georges S. Aoude, Brandon D, potentially errant, drivers. Our approach relies on a novel threat assessment module, which combines an intention predictor based on support vector machines with an efficient threat assessor using rapidly

  13. Factors influencing field performance: utilizing the drug evaluation and classificaiton (DEC) program to identify suspected impaired drivers as reported by selected certified police officers in Texas

    E-Print Network [OSTI]

    Walden, Melissa Noggle

    2009-05-15T23:59:59.000Z

    impaired drivers. Specifically, this study explored how particular factors observed as part of the DEC Program’s decision-making process influence the DRE’s prediction of a drug category that was impairing a suspected impaired driver in the enforcement...

  14. Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon

    E-Print Network [OSTI]

    Bertini, Robert L.

    Motor Vehicle Crash Fatalities and Injuries: An Analysis of the Relationship of Roadway, Driver, Vehicle Characteristics in Oregon Motor Vehicle Crash Fatalities and Injuries: An Analysis,000 population among Oregon counties from 2000-2005 ranged from 6.64-211.17. In the event of a severe motor

  15. Driving, Aging & Dementia: On-Line Resources Division of Motor Vehicles & Driver Licensing, Missouri Department of Revenue

    E-Print Network [OSTI]

    Driving, Aging & Dementia: On-Line Resources Missouri Division of Motor Vehicles & Driver Licensing for Responsible Driving, Inc. http://www.drivingsafe.org/ Alzheimer's Association, St. Louis Chapter (Driving & Driving (The Hartford Insurance Corp.) http://www.thehartford.com/alzheimers/ Family Conversations

  16. Environmental science and ecology involve studies

    E-Print Network [OSTI]

    Christensen, Dan

    Environmental science and ecology involve studies of the biosphere, hydro- sphere, and lithosphere in environmental science is conducted on spatial scales varying from a single algal cell to the Earth as a whole's environmental scientists require investigation by an interdisciplinary team, including members from several

  17. Increasing Public Involvement in Structural Biology

    E-Print Network [OSTI]

    Baker, David

    --often referred to as citizen science--provides a means of engaging people's skills, rather than just for the public to get actively involved in structural biology research? Citizen science projects can require areas for citizen science as structural problems both are amenable to human spatial-reasoning skills

  18. Nearby Outdoor Environmental Support of Older Adults' Yard Activities, Neighborhood Walking and Independent Living in the Community

    E-Print Network [OSTI]

    Wang, Zhe

    2011-02-22T23:59:59.000Z

    to remain healthy and gives them the ability to access daily-life services, and thus extend their independent years at home. Nearby outdoor environments on residential sites and in the neighborhoods may influence older adults' independent living through...

  19. The impact of urban form on older adults : focusing on neighborhood design and baby boomers' local behavior

    E-Print Network [OSTI]

    Lee, Jae Seung, Ph. D. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    The growing share of older adults across the globe raises concern about active and safe aging. This dissertation examines aging baby boomers' travel and social behavior resulting from neighborhood design. The body of the ...

  20. Relationships Between the Built Environment and Walking and Weight Status Among Older Women in Three U.S. States

    E-Print Network [OSTI]

    Troped, Philip J.

    There are few studies of built environment associations with physical activity and weight status among older women in large geographic areas that use individual residential buffers to define environmental exposures. Among ...

  1. The effects of neighborhood environments on the level of physical activity among older african american women in Texas 

    E-Print Network [OSTI]

    Shin, Woo Hwa

    2009-05-15T23:59:59.000Z

    The older African American women living Texas fall into one of the most inactive population segments. Recently, the importance of socio-ecological models on human health behavior and more complex associations between ...

  2. Regulation of the genes involved in nitrification.

    SciTech Connect (OSTI)

    Arp, D.J.; Sayavedra-Soto, L.A.

    2003-08-14T23:59:59.000Z

    OAK-B135 This project focuses on the characterization of the regulation of the genes involved in nitrification in the bacterium Nitrosomonas europaea. The key genes in the nitrification pathway, amo and hao, are present in multiple copies in the genome. The promoters for these genes were identified and characterized. It was shown that there were some differences in the transcriptional regulation of the copies of these genes.

  3. Community Involvement Fund | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsNovember 13, 2014 BuildingEnergy EfficiencyPast ProjectsCommunity Involvement

  4. Where Are The M Dwarf Disks Older Than 10 Million Years?

    E-Print Network [OSTI]

    Peter Plavchan; M. Jura; S. J. Lipscy

    2005-06-07T23:59:59.000Z

    We present 11.7-micron observations of nine late-type dwarfs obtained at the Keck I 10-meter telescope in December 2002 and April 2003. Our targets were selected for their youth or apparent IRAS 12-micron excess. For all nine sources, excess infrared emission is not detected. We find that stellar wind drag can dominate the circumstellar grain removal and plausibly explain the dearth of M Dwarf systems older than 10 Myr with currently detected infrared excesses. We predict M dwarfs possess fractional infrared excess on the order of L_{IR}/L_{*}\\sim10^{-6} and this may be detectable with future efforts.

  5. The high current, fast, 100ns, Linear Transformer Driver (LTD) developmental project at Sandia National Laboratories.

    SciTech Connect (OSTI)

    Ward, Kevin S.; Long, Finis W.; Sinebryukhov, Vadim A. (High Current Electronic Institute (HCEI), Tomsk, Russia); Kim, Alexandre A. (High Current Electronic Institute (HCEI), Tomsk, RUSSIA); Wakeland, Peter Eric (Ktech Corporation, Albuquerque, NM); McKee, G. Randall; Woodworth, Joseph Ray; McDaniel, Dillon Heirman; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John Larry, Jr.; Struve, Kenneth William; Stygar, William A.; LeChien, Keith R.; Matzen, Maurice Keith

    2010-04-01T23:59:59.000Z

    Sandia National Laboratories, Albuquerque, N.M., USA, in collaboration with the High Current Electronic Institute (HCEI), Tomsk, Russia, is developing a new paradigm in pulsed power technology: the Linear Transformer Driver (LTD) technology. This technological approach can provide very compact devices that can deliver very fast high current and high voltage pulses straight out of the cavity with out any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The load may be a vacuum electron diode, a z-pinch wire array, a gas puff, a liner, an isentropic compression load (ICE) to study material behavior under very high magnetic fields, or a fusion energy (IFE) target. This is because the output pulse rise time and width can be easily tailored to the specific application needs. In this paper we briefly summarize the developmental work done in Sandia and HCEI during the last few years, and describe our new MYKONOS Sandia High Current LTD Laboratory.

  6. BEAM DYNAMICS SIMULATIONS OF SARAF ACCELERATOR INCLUDING ERROR PROPAGATION AND IMPLICATIONS FOR THE EURISOL DRIVER

    E-Print Network [OSTI]

    J. Rodnizki, D. Berkovits, K. Lavie, I. Mardor, A. Shor and Y. Yanay (Soreq NRC, Yavne), K. Dunkel, C. Piel (ACCEL, Bergisch Gladbach), A. Facco (INFN/LNL, Legnaro, Padova), V. Zviagintsev (TRIUMF, Vancouver)

    AbstractBeam dynamics simulations of SARAF (Soreq Applied Research Accelerator Facility) superconducting RF linear accelerator have been performed in order to establish the accelerator design. The multi-particle simulation includes 3D realistic electromagnetic field distributions, space charge forces and fabrication, misalignment and operation errors. A 4 mA proton or deuteron beam is accelerated up to 40 MeV with a moderated rms emittance growth and a high real-estate gradient of 2 MeV/m. An envelope of 40,000 macro-particles is kept under a radius of 1.1 cm, well below the beam pipe bore radius. The accelerator design of SARAF is proposed as an injector for the EURISOL driver accelerator. The Accel 176 MHZ ?0=0.09 and ?0=0.15 HWR lattice was extended to 90 MeV based on the LNL 352 MHZ ?0=0.31 HWR. The matching between both lattices ensures smooth transition and the possibility to extend the accelerator to the required EURISOL ion energy.

  7. Studies Of Coherent Synchrotron Radiation And Longitudinal Space Charge In The Jefferson Lab FEL Driver

    SciTech Connect (OSTI)

    Tennant, Christopher D. [JLAB; Douglas, David R. [JLAB; Li, Rui [JLAB; Tsai, C.-Y. [Virginia Polytechnic University

    2014-12-01T23:59:59.000Z

    The Jefferson Laboratory IR FEL Driver provides an ideal test bed for studying a variety of beam dynamical effects. Recent studies focused on characterizing the impact of coherent synchrotron radiation (CSR) with the goal of benchmarking measurements with simulation. Following measurements to characterize the beam, we quantitatively characterized energy extraction via CSR by measuring beam position at a dispersed location as a function of bunch compression. In addition to operating with the beam on the rising part of the linac RF waveform, measurements were also made while accelerating on the falling part. For each, the full compression point was moved along the backleg of the machine and the response of the beam (distribution, extracted energy) measured. Initial results of start-to-end simulations using a 1D CSR algorithm show remarkably good agreement with measurements. A subsequent experiment established lasing with the beam accelerated on the falling side of the RF waveform in conjunction with positive momentum compaction (R56) to compress the bunch. The success of this experiment motivated the design of a modified CEBAF-style arc with control of CSR and microbunching effects.

  8. SPL-based Proton Driver for a nu-Factory at CERN

    E-Print Network [OSTI]

    Benedetto, E; Garoby, R; Meddahi, M

    2010-01-01T23:59:59.000Z

    The conceptual design and feasibility studies for a nu-Factory Proton Driver based on the CERN Superconducting Proton Linac (SPL) have been com- pleted. In the proposed scenario, the 4 MW proton beam (H- beam) is acceler- ated with the upgraded High Power (HP)-SPL to 5 GeV, stored in an accumu- lator ring and Þnally transported to a compressor ring, where bunch rotation takes place, in order to achieve the speciÞc time structure. We here summa- rize the choices in terms of lattice, magnet technology and RF manipulations in the two rings. The possible critical issues, such as heating of the foil for the charge-exchange injection, space-charge problems in the compressor and beam stability in the accumulator ring, have been addressed and are shown not to be show-stoppers. The analysis focuses on the baseline scenario, consider- ing 6 bunches in the accumulator, and preliminary studies are discussed for the option of 3 or a single bunch per burst.

  9. MHz repetition rate solid-state driver for high current induction accelerators

    SciTech Connect (OSTI)

    Brooksby, C; Caporaso, G; Goerz, D; Hanks, R; Hickman, B; Kirbie, H; Lee, B; Saethre, R

    1999-03-01T23:59:59.000Z

    A research team from the Lawrence Livermore National Laboratory and Bechtel Nevada Corporation is developing an all solid-state power source for high current induction accelerators. The original power system design, developed for heavy-ion fusion accelerators, is based on the simple idea of using an array of field effect transistors to switch energy from a pre-charged capacitor bank to an induction accelerator cell. Recently, that idea has been expanded to accommodate the greater power needs of a new class of high-current electron accelerators for advanced radiography. For this purpose, we developed a 3-stage induction adder that uses over 4,000 field effect transistors to switch peak voltages of 45 kV at currents up to 4.8 kA with pulse repetition rates of up to 2 MHz. This radically advanced power system can generate a burst of five or more pulses that vary from 200 ns to 2 µs at a duty cycle of up to 25%. Our new source is precise, robust, flexible, and exceeds all previous drivers for induction machines by a factor of 400 in repetition rate and a factor of 1000 in duty cycle.

  10. Ferroelectric plasma sources for NDCX-II and heavy ion drivers E.P. Gilson a,n

    E-Print Network [OSTI]

    Gilson, Erik

    a , P.C. Efthimion a , I.D. Kaganovich a , J.W. Kwan b , S.M. Lidia b , P.A. Ni b , P.K. Roy b , PFerroelectric plasma sources for NDCX-II and heavy ion drivers E.P. Gilson a,n , R.C. Davidson, Princeton University, P.O. Box 451, Princeton, New Jersey, 08543, USA b Lawrence Berkeley National

  11. Using a growth and yield model (PTAEDA2) as a driver for a biological process model (MAESTRO). Forest Service research paper

    SciTech Connect (OSTI)

    Baldwin, V.C.; Burkhart, H.E.; Dougherty, P.M.; Teskey, R.O.

    1993-08-01T23:59:59.000Z

    The objectives, approach, and results of the modeling required to adapt the management oriented growth and yield model (PTAEDA2) to function as a driver for the biologically based process model (MAESTRO) are discussed in the report.

  12. Assessing Energy Impact of Plug-In Hybrid Electric Vehicles: Significance of Daily Distance Variation over Time and Among Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong [ORNL; Greene, David L [ORNL

    2012-01-01T23:59:59.000Z

    Accurate assessment of the impact of plug-in hybrid electric vehicles (PHEVs) on petroleum and electricity consumption is a necessary step toward effective policies. Variations in daily vehicle miles traveled (VMT) over time and among drivers affect PHEV energy impact, but the significance is not well understood. This paper uses a graphical illustration, a mathematical derivation, and an empirical study to examine the cause and significance of such an effect. The first two methods reveal that ignoring daily variation in VMT always causes underestimation of petroleum consumption and overestimation of electricity consumption by PHEVs; both biases increase as the assumed PHEV charge-depleting (CD) range moves closer to the average daily VMT. The empirical analysis based on national travel survey data shows that the assumption of uniform daily VMT over time and among drivers causes nearly 68% underestimation of expected petroleum use and nearly 48% overestimation of expected electricity use by PHEVs with a 40-mi CD range (PHEV40s). Also for PHEV40s, consideration of daily variation in VMT over time but not among drivers similar to the way the utility factor curve is derived in SAE Standard SAE J2841 causes underestimation of expected petroleum use by more than 24% and overestimation of expected electricity use by about 17%. Underestimation of petroleum use and overestimation of electricity use increase with larger-battery PHEVs.

  13. Apolipoprotein gene involved in lipid metabolism

    DOE Patents [OSTI]

    Rubin, Edward (Berkeley, CA); Pennacchio, Len A. (Sebastopol, CA)

    2007-07-03T23:59:59.000Z

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  14. Farmer involvement in a reforestation research project in Costa Rica

    E-Print Network [OSTI]

    Toness, Anna Sutherland

    1993-01-01T23:59:59.000Z

    Research Project In Costa Rica Anna Sutherland Toness INTRODVCTION Widespread concern has risen in recent years over the increasing amount of deforestation in the tropics (Armis, 1992; Southgate et al. , 1991; Myers, 1991; Clay, 1988). Deforestation.... Citations follow the style of International Forestry Deforestation in tropical areas is also potentially more dangerous than in temperate forests. Tropical soils being much older and more highly weathered than temperate soils, no longer have the nutrient...

  15. Energy for 500 Million Homes: Drivers and Outlook for Residential Energy Consumption in China

    SciTech Connect (OSTI)

    Zhou, Nan; McNeil, Michael A.; Levine, Mark

    2009-06-01T23:59:59.000Z

    China's rapid economic expansion has propelled it to the rank of the largest energy consuming nation in the world, with energy demand growth continuing at a pace commensurate with its economic growth. The urban population is expected to grow by 20 million every year, accompanied by construction of 2 billion square meters of buildings every year through 2020. Thus residential energy use is very likely to continue its very rapid growth. Understanding the underlying drivers of this growth helps to identify the key areas to analyze energy efficiency potential, appropriate policies to reduce energy use, as well as to understand future energy in the building sector. This paper provides a detailed, bottom-up analysis of residential building energy consumption in China using data from a wide variety of sources and a modelling effort that relies on a very detailed characterization of China's energy demand. It assesses the current energy situation with consideration of end use, intensity, and efficiency etc, and forecast the future outlook for the critical period extending to 2020, based on assumptions of likely patterns of economic activity, availability of energy services, technology improvement and energy intensities. From this analysis, we can conclude that Chinese residential energy consumption will more than double by 2020, from 6.6 EJ in 2000 to 15.9 EJ in 2020. This increase will be driven primarily by urbanization, in combination with increases in living standards. In the urban and higher income Chinese households of the future, most major appliances will be common, and heated and cooled areas will grow on average. These shifts will offset the relatively modest efficiency gains expected according to current government plans and policies already in place. Therefore, levelling and reduction of growth in residential energy demand in China will require a new set of more aggressive efficiency policies.

  16. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01T23:59:59.000Z

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  17. Public involvement in radioactive waste management decisions

    SciTech Connect (OSTI)

    NONE

    1994-04-01T23:59:59.000Z

    Current repository siting efforts focus on Yucca Mountain, Nevada, where DOE`s Office of Civilian Radioactive Waste Management (OCRWM) is conducting exploratory studies to determine if the site is suitable. The state of Nevada has resisted these efforts: it has denied permits, brought suit against DOE, and publicly denounced the federal government`s decision to study Yucca Mountain. The state`s opposition reflects public opinion in Nevada, and has considerably slowed DOE`s progress in studying the site. The Yucca Mountain controversy demonstrates the importance of understanding public attitudes and their potential influence as DOE develops a program to manage radioactive waste. The strength and nature of Nevada`s opposition -- its ability to thwart if not outright derail DOE`s activities -- indicate a need to develop alternative methods for making decisions that affect the public. This report analyzes public participation as a key component of this openness, one that provides a means of garnering acceptance of, or reducing public opposition to, DOE`s radioactive waste management activities, including facility siting and transportation. The first section, Public Perceptions: Attitudes, Trust, and Theory, reviews the risk-perception literature to identify how the public perceives the risks associated with radioactivity. DOE and the Public discusses DOE`s low level of credibility among the general public as the product, in part, of the department`s past actions. This section looks at the three components of the radioactive waste management program -- disposal, storage, and transportation -- and the different ways DOE has approached the problem of public confidence in each case. Midwestern Radioactive Waste Management Histories focuses on selected Midwestern facility-siting and transportation activities involving radioactive materials.

  18. Key regulatory drivers affecting shipments of mixed transuranic waste from Los Alamos National Laboratory to the Waste Isolation Pilot Plant

    SciTech Connect (OSTI)

    Schumann, P.B.; Bacigalupa, G.A.; Kosiewicz, S.T.; Sinkule, B.J. [and others

    1997-02-01T23:59:59.000Z

    A number of key regulatory drivers affect the nature, scope, and timing of Los Alamos National Laboratory`s (LANL`s) plans for mixed transuranic (MTRU) waste shipments to the Waste Isolation Pilot Plant (WIPP), which are planned to commence as soon as possible following WIPP`s currently anticipated November, 1997 opening date. This paper provides an overview of some of the key drivers at LANL, particularly emphasizing those associated with the hazardous waste component of LANL`s MTRU waste (MTRU, like any mixed waste, contains both a radioactive and a hazardous waste component). The key drivers discussed here derive from the federal Resource Conservation and Recovery Act (RCRA) and its amendments, including the Federal Facility Compliance Act (FFCAU), and from the New Mexico Hazardous Waste Act (NMHWA). These statutory provisions are enforced through three major mechanisms: facility RCRA permits; the New Mexico Hazardous Waste Management Regulations, set forth in the New Mexico Administrative Code, Title 20, Chapter 4, Part 1: and compliance orders issued to enforce these requirements. General requirements in all three categories will apply to MTRU waste management and characterization activities at both WIPP and LANL. In addition, LANL is subject to facility-specific requirements in its RCRA hazardous waste facility permit, permit conditions as currently proposed in RCRA Part B permit applications presently being reviewed by the New Mexico Environment Department (NNED), and facility-specific compliance orders related to MTRU waste management. Likewise, permitting and compliance-related requirements specific to WIPP indirectly affect LANL`s characterization, packaging, record-keeping, and transportation requirements for MTRU waste. LANL must comply with this evolving set of regulatory requirements to begin shipments of MTRU waste to WIPP in a timely fashion.

  19. Agricultural green revolution as a driver of increasing atmospheric CO2 seasonal amplitude

    SciTech Connect (OSTI)

    Zeng, Ning; Zhao, Fang; Collatz, George; Kalnay, Eugenia; Salawitch, Ross J.; West, Tristram O.; Guanter, Luis

    2014-11-20T23:59:59.000Z

    The atmospheric carbon dioxide (CO2) record displays a prominent seasonal cycle that arises mainly from changes in vegetation growth and the corresponding CO2 uptake during the boreal spring and summer growing seasons and CO2 release during the autumn and winter seasons. The CO2 seasonal amplitude has increased over the past five decades, suggesting an increase in Northern Hemisphere biospheric activity. It has been proposed that vegetation growth may have been stimulated by higher concentrations of CO2 as well as by warming in recent decades, but such mechanisms have been unable to explain the full range and magnitude of the observed increase in CO2 seasonal amplitude. Here we suggest that the intensification of agriculture (the Green Revolution, in which much greater crop yield per unit area was achieved by hybridization, irrigation and fertilization) during the past five decades is a driver of changes in the seasonal characteristics of the global carbon cycle. Our analysis of CO2 data and atmospheric inversions shows a robust 15 per cent long-term increase in CO2 seasonal amplitude from 1961 to 2010, punctuated by large decadal and interannual variations. Using a terrestrial carbon cycle model that takes into account high-yield cultivars, fertilizer use and irrigation, we find that the long-term increase in CO2 seasonal amplitude arises from two major regions: the mid-latitude cropland between 256N and 606N and the high-latitude natural vegetation between 506N and 706 N. The long-term trend of seasonal amplitude increase is 0.311 ± 0.027 percent per year, of which sensitivity experiments attribute 45, 29 and 26 per cent to land-use change, climate variability and change, and increased productivity due to CO2 fertilization, respectively. Vegetation growth was earlier by one to two weeks, as measured by the mid-point of vegetation carbon uptake, and took up 0.5 petagrams more carbon in July, the height of the growing season, during 2001–2010 than in 1961–1970, suggesting that human land use and management contribute to seasonal changes in the CO2 exchange between the biosphere and the atmosphere.

  20. Rapid embedded wire heating via resistive guiding of laser-generated fast electrons as a hydrodynamic driver

    SciTech Connect (OSTI)

    Robinson, A. P. L.; Schmitz, H. [Central Laser Facility, STFC Rutherford-Appleton Laboratory, Didcot OX11 0QX (United Kingdom)] [Central Laser Facility, STFC Rutherford-Appleton Laboratory, Didcot OX11 0QX (United Kingdom); Pasley, J. [Central Laser Facility, STFC Rutherford-Appleton Laboratory, Didcot OX11 0QX (United Kingdom) [Central Laser Facility, STFC Rutherford-Appleton Laboratory, Didcot OX11 0QX (United Kingdom); York Plasma Institute, University of York, York YO10 5DD (United Kingdom)

    2013-12-15T23:59:59.000Z

    Resistively guiding laser-generated fast electron beams in targets consisting of a resistive wire embedded in lower Z material should allow one to rapidly heat the wire to over 100 eV over a substantial distance without strongly heating the surrounding material. On the multi-ps timescale, this can drive hydrodynamic motion in the surrounding material. Thus, ultra-intense laser solid interactions have the potential as a controlled driver of radiation hydrodynamics in solid density material. In this paper, we assess the laser and target parameters needed to achieve such rapid and controlled heating of the embedded wire.

  1. Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Cassard, H.; Denholm, P.; Ong, S.

    2011-02-01T23:59:59.000Z

    This paper examines the break-even cost for residential rooftop solar water heating (SWH) technology, defined as the point where the cost of the energy saved with a SWH system equals the cost of a conventional heating fuel purchased from the grid (either electricity or natural gas). We examine the break-even cost for the largest 1,000 electric and natural gas utilities serving residential customers in the United States as of 2008. Currently, the break-even cost of SWH in the United States varies by more than a factor of five for both electricity and natural gas, despite a much smaller variation in the amount of energy saved by the systems (a factor of approximately one and a half). The break-even price for natural gas is lower than that for electricity due to a lower fuel cost. We also consider the relationship between SWH price and solar fraction and examine the key drivers behind break-even costs. Overall, the key drivers of the break-even cost of SWH are a combination of fuel price, local incentives, and technical factors including the solar resource location, system size, and hot water draw.

  2. A Self-advocacy Program for Students with Disabilities: Adult Outcomes and Advocacy Involvement One to Six Years after Involvement

    E-Print Network [OSTI]

    Roberts, Eric

    2013-03-08T23:59:59.000Z

    attendance was higher than the national average for adults with disabilities. Participants with low incidence disabilities were involved in inclusive employment more often than the national average. A minority status increased the likelihood of involvement...

  3. Currently, in countries where automobiles are moving on the right, drivers are required to drive in the rightmost lane. To overtake another vehicle, they move one lane to the left, pass, and return to their

    E-Print Network [OSTI]

    Morrow, James A.

    Summary Currently, in countries where automobiles are moving on the right, drivers are required automobiles travel on the left. Finally, in "Further Thinking", we try to integrate more factors to improve February 11, 2014 Abstract Currently, in countries where automobiles are moving on the right, drivers

  4. Older and Colder: The impact of starspots on pre-main sequence stellar evolution

    E-Print Network [OSTI]

    Somers, Garrett

    2015-01-01T23:59:59.000Z

    We assess the impact of starspots on the evolution of late-type stars during the pre-main sequence (pre-MS) using a modified stellar evolution code. We find that heavily spotted models of mass 0.1-1.2\\msun\\ are inflated by up to $10$% during the pre-MS, and up to 4% and 9% for fully- and partially-convective stars at the zero-age MS, consistent with measurements from active eclipsing binary systems. Spots similarly decrease stellar luminosity and $T_{\\rm eff}$, causing isochrone-derived masses to be under-estimated by up to a factor of $2 \\times$, and ages to be under-estimated by a factor of 2-10$\\times$, at 3 Myr. Consequently, pre-MS clusters and their active stars are systematically older and more massive than often reported. Cluster ages derived with the lithium depletion boundary technique are erroneously young by $\\sim 15$% and $10$% at $30$ and $100$ Myr respectively, if 50% spotted stars are interpreted with un-spotted models. Finally, lithium depletion is suppressed in spotted stars with radiative c...

  5. IZw18, or the picture of Dorian Gray: the more you watch it, the older it gets

    E-Print Network [OSTI]

    F. Combes; J. Palous; M. Tosi; A. Aloisi; J. Mack; M. Maio

    2006-01-01T23:59:59.000Z

    Abstract. IZw18 has been recurrently claimed to be a young galaxy, but stars of increasingly older ages are found every time deeper magnitude levels are reached with high-resolution photometry: from the original few Myrs to, possibly, several Gyrs. We summarize the history of IZw18’s age and an HST project which will allow us to derive both its distance and age.

  6. The effects of gardening on quality of life of older adults living in long-term care settings

    E-Print Network [OSTI]

    Hartman, Ashley Irene

    2002-01-01T23:59:59.000Z

    are not classified as diseases, they often go unchecked and can lead to more serious psychological illnesses such as major depression (Davis, 1994; Thomas, 1994). According to the National Institute of Mental Health (2000), major depression among those ages 65...THE EFFECTS OF GARDENING ON QUALITY OF LIFE OF OLDER ADULTS LIVING IN LONG-TERM CARE SETTINGS A Thesis by ASHLEY IRENE HARTMAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements...

  7. The effects of neighborhood environments on the level of physical activity among older african american women in Texas

    E-Print Network [OSTI]

    Shin, Woo Hwa

    2009-05-15T23:59:59.000Z

    , that provide social identity, support, and role definition Institutional Factors Rules, regulations, policies, and informal structures, which may constrain or promote recommended behaviors Community Factors Social networks and norms, or standards, which... courts, or bowling greens. (Booth et al., 2000) Older women who perceived that biking or walking trails, or parks located within 20 minute-walking distance from their homes showed significantly higher levels of pedometer walking records than those who...

  8. Aluminum and tungsten X-pinch experiments on 100 kA, 100 ns linear transformer driver stage

    SciTech Connect (OSTI)

    Wu Jian [Department of Engineering Physics, Tsinghua University, Beijing 10086 (China); Northwest Institute of Nuclear Technology, Xi'an 710024 (China); Sun Tieping; Wu Gang; Wang Liangping; Han Juanjuan; Li Mo; Cong Peitian; Qiu Aici [Northwest Institute of Nuclear Technology, Xi'an 710024 (China); Lv Min [Department of Engineering Physics, Tsinghua University, Beijing 10086 (China)

    2011-05-15T23:59:59.000Z

    X-pinch experiments have been carried out on a 100 kA, 100 ns linear transformer driver stage recently built up. The X-pinches exhibited a source size of about 10 {mu}m, a pulse duration of 3 ns, 3-5 keV radiation energy of 3.9 mJ, and a burst time jitter of tens of nanosecond with the 2-wire 8 {mu}m W X-pinch load. The generator output current and the X-pinch characteristics depended on the X-pinch wire materials in the tests. X-ray backlighting images from the insects showed the significant phase-contrast effect.

  9. Migration: An engine for social change The movement of people into societies that offer a better way of life is a more powerful driver of cultural

    E-Print Network [OSTI]

    Richerson, Peter J.

    Migration: An engine for social change The movement of people into societies that offer a better way of life is a more powerful driver of cultural evolution than conflict and conquest, say Peter effect on how societies evolve cul- turally because it is selective. People move to societies

  10. IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS, VOL. , NO. , 2012 1 Dynamic Driver Supply Voltage Scaling for Organic

    E-Print Network [OSTI]

    Pedram, Massoud

    Dynamic Driver Supply Voltage Scaling for Organic Light Emitting Diode Displays Donghwa Shin, Student, Fellow, IEEE Abstract--Organic light emitting diode (OLED) display is a self-illuminating device]. On the other hand, an organic light emitting diode (OLED) is self-illuminating using organic light emission

  11. IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS--I: REGULAR PAPERS, VOL. 57, NO. 8, AUGUST 2010 2099 A 4 GHz Non-Resonant Clock Driver With

    E-Print Network [OSTI]

    Lemieux, Guy

    capacitance back to the on-chip power-distribution grid. We call this type of return energy recycling in this new clock driver is about 6% of a local clock region. Index Terms--Charge recycling, energy recycling in battery-powered applications, but also in other designs because of packaging, cooling and operating costs

  12. SiGe Prototype Chip Design Implementing CMOS Fixed Bit-Load Drivers and Receivers for Next Generation High-Speed Board-Level Interconnect

    E-Print Network [OSTI]

    Bakos, Jason D.

    SiGe Prototype Chip Design Implementing CMOS Fixed Bit-Load Drivers and Receivers for Next. These designs were fabricated as part of a multi-project die in IBM's .5um 5HP SiGe process. 1. Introduction Figure 1 shows our multi-project test die, manufactured in IBM's .5 um 5HP SiGe process. In this paper

  13. active user involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    architecture. DBS was implemented on the Nano-Threads Programming Model (NPM) as part of NANOS, a large-scale project involving the development of a runtime...

  14. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    Magistretti PJ: Brain energy metabolism: focus on astrocyte?involved  in  various  energy  metabolism  processes  that cycle for oxidative energy metabolism and for production of 

  15. Microsoft Word - Number of Public Involvement Deliverables _2...

    National Nuclear Security Administration (NNSA)

    numerous (+150) video clips and raw video * Maintain the Public Involvement portion of web-based Environmental Management Information System (includes uploading briefings,...

  16. activity involving yb-1: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  17. adenylyl cyclase involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  18. ahr repressor involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  19. anaemia potential involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  20. antigens predominant involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  1. actinobacillus pleuropneumoniae involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  2. aedes aegypti involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  3. accidental fatalities involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  4. adenosinergic system involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  5. aspergillus nidulans involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  6. aminoguanidine involve reduced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  7. arteriovenous malformations involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  8. alternata involves active: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  9. anterior prefrontal involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  10. adjuvant involved field: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  11. asymptomatic lymphangioma involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  12. alternaria alternata involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  13. antinociception involves endogenous: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  14. apoptosis involving activation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  15. arteriovenous malformation involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  16. accidents involving external: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    25 Next Page Last Page Topic Index 1 Development and use of the ESReDA directory of accident databases involving chemicals Computer Technologies and Information Sciences Websites...

  17. ‘Balancing complexity, resources and demand’ : a grounded theory of clinical decision making in psychological therapy for older people with posttraumatic stress symptoms. 

    E-Print Network [OSTI]

    Billett, Jane

    2014-07-01T23:59:59.000Z

    Background: Preliminary evidence suggests there are differences in how older people and younger people with posttraumatic stress disorder (PTSD) present. However, currently little robust evidence exists relating to the ...

  18. A life-course perspective on U.S. migration experience and later-life diabetes, hypertension, and depression for middle-aged and older Mexican adults

    E-Print Network [OSTI]

    Torres, Jacqueline Marie

    2014-01-01T23:59:59.000Z

    pathways to adult-onset diabetes. Soc Biol, 52(3-4), 94-111.by older Mexicans with diabetes: how migration to the UnitedG. (2010). Social determinants of diabetes and challenges of

  19. INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis

    SciTech Connect (OSTI)

    Ausin, Israel; Greenberg, Maxim V.C.; Simanshu, Dhirendra K.; Hale, Christopher J.; Vashisht, Ajay A.; Simon, Stacey A.; Lee, Tzuu-fen; Feng, Suhua; Española, Sophia D.; Meyers, Blake C.; Wohlschlegel, James A.; Patel, Dinshaw J.; Jacobsen, Steven E. (UCLA); (MSKCC); (Delaware)

    2012-10-23T23:59:59.000Z

    At least three pathways control maintenance of DNA cytosine methylation in Arabidopsis thaliana. However, the RNA-directed DNA methylation (RdDM) pathway is solely responsible for establishment of this silencing mark. We previously described INVOLVED IN DE NOVO 2 (IDN2) as being an RNA-binding RdDM component that is required for DNA methylation establishment. In this study, we describe the discovery of two partially redundant proteins that are paralogous to IDN2 and that form a stable complex with IDN2 in vivo. Null mutations in both genes, termed IDN2-LIKE 1 and IDN2-LIKE 2 (IDNL1 and IDNL2), result in a phenotype that mirrors, but does not further enhance, the idn2 mutant phenotype. Genetic analysis suggests that this complex acts in a step in the downstream portion of the RdDM pathway. We also have performed structural analysis showing that the IDN2 XS domain adopts an RNA recognition motif (RRM) fold. Finally, genome-wide DNA methylation and expression analysis confirms the placement of the IDN proteins in an RdDM pathway that affects DNA methylation and transcriptional control at many sites in the genome. Results from this study identify and describe two unique components of the RdDM machinery, adding to our understanding of DNA methylation control in the Arabidopsis genome.

  20. LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING

    E-Print Network [OSTI]

    LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING GEOSYTNTHETICS Virginia L. Wilson: Geosynthetics: Lessons Learned from Failures International Geosynthetics Society editors J.P. Giroud, K.L. Soderman and G.P. Raymond November 12, 1998 #12;LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING

  1. Lessons Learned from Failures Involving Geofoam in Roads and Embankments

    E-Print Network [OSTI]

    Horvath, John S.

    Lessons Learned from Failures Involving Geofoam in Roads and Embankments Manhattan College Research July 1999) #12;Lessons Learned from Failures Involving Geofoam in Roads and Embankments Manhattan College Research Report No. CE/GE-99-1 ii This page intentionally left blank. #12;Lessons Learned from

  2. Citizen Involvement in Water Resources Issues in New England

    E-Print Network [OSTI]

    Gold, Art

    was developed and conducted in May of 2005. This survey was based on a template developed in the PacificCitizen Involvement in Water Resources Issues in New England Abstract A survey determined citizen the degree of current citizen involvement in water resources issues in New England, a public opinion survey

  3. Massive Scale Cyber Traffic Analysis: A Driver for Graph Database Research

    SciTech Connect (OSTI)

    Joslyn, Cliff A.; Choudhury, S.; Haglin, David J.; Howe, Bill; Nickless, William K.; Olsen, Bryan K.

    2013-06-19T23:59:59.000Z

    We describe the significance and prominence of network traffic analysis (TA) as a graph- and network-theoretical domain for advancing research in graph database systems. TA involves observing and analyzing the connections between clients, servers, hosts, and actors within IP networks, both at particular times and as extended over times. Towards that end, NetFlow (or more generically, IPFLOW) data are available from routers and servers which summarize coherent groups of IP packets flowing through the network. IPFLOW databases are routinely interrogated statistically and visualized for suspicious patterns. But the ability to cast IPFLOW data as a massive graph and query it interactively, in order to e.g.\\ identify connectivity patterns, is less well advanced, due to a number of factors including scaling, and their hybrid nature combining graph connectivity and quantitative attributes. In this paper, we outline requirements and opportunities for graph-structured IPFLOW analytics based on our experience with real IPFLOW databases. Specifically, we describe real use cases from the security domain, cast them as graph patterns, show how to express them in two graph-oriented query languages SPARQL and Datalog, and use these examples to motivate a new class of "hybrid" graph-relational systems.

  4. Voluntary Associations and Their Involvement in Collaborative Forest Management

    E-Print Network [OSTI]

    Lu, Jiaying

    2012-02-14T23:59:59.000Z

    . This dissertation was aimed at gaining a better understanding of outdoor recreation and environmental voluntary associations and their involvement in collaborative forest management. Five objectives guided this study: (1) assessing the organizational characteristics...

  5. Unsaturated geotechnics applied to geoenvironmental engineering problems involving geosynthetics

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    such as geotextiles and geosynthetic clay liners (GCLs) with particular focus on capillary barriers, liner performanceUnsaturated geotechnics applied to geoenvironmental engineering problems involving geosynthetics Available online 15 February 2013 Keywords: Capillary break Desiccation Flow Geosynthetics Interface shear

  6. A fast enriched FEM for Poisson equations involving interfaces

    E-Print Network [OSTI]

    Huynh, Thanh Le Ngoc

    2008-01-01T23:59:59.000Z

    We develop a fast enriched finite element method for solving Poisson equations involving complex geometry interfaces by using regular Cartesian grids. The presence of interfaces is accounted for by developing suitable jump ...

  7. Accident Procedure Outline the procedures for accidents involving University of Michigan (U-M) vehicles.

    E-Print Network [OSTI]

    Kirschner, Denise

    owned by U-M are covered by the U-M self insurance program administered by Risk Management. Procedure 1. An accident is defined as any incident that causes damage to people or property. 2. In the event. 4. If the accident causes personal injury to the driver, occupants and/or pedestrian, contact Risk

  8. Design of a 7-MV Linear Transformer Driver (LTD) for down-hole flash x-ray radiography.

    SciTech Connect (OSTI)

    Cordova, Steve Ray; Welch, Dale Robert (Voss Scientific, Albuquerque, NM); Oliver, Bryan Velten; Rose, David Vincent (Voss Scientific, Albuquerque, NM); Johnson, David Lee (L-3 Communications - Pulse Sciences, San Leandro, CA); Bruner, Nichelle Lee (Voss Scientific, Albuquerque, NM); Leckbee, Joshua J.

    2008-09-01T23:59:59.000Z

    Pulsed power driven flash x-ray radiography is a valuable diagnostic for subcritical experiments at the Nevada Test Site. The existing dual-axis Cygnus system produces images using a 2.25 MV electron beam diode to produce intense x-rays from a small source. Future hydrodynamic experiments will likely use objects with higher areal mass, requiring increased x-ray dose and higher voltages while maintaining small source spot size. A linear transformer driver (LTD) is a compact pulsed power technology with applications ranging from pulsed power flash x-ray radiography to high current Z-pinch accelerators. This report describes the design of a 7-MV dual-axis system that occupies the same lab space as the Cygnus accelerators. The work builds on a design proposed in a previous report [1]. This new design provides increased diode voltage from a lower impedance accelerator to improve coupling to low impedance diodes such as the self magnetic pinch (SMP) diode. The design also improves the predicted reliability by operating at a lower charge voltage and removing components that have proven vulnerable to failure. Simulations of the new design and experimental results of the 1-MV prototype are presented.

  9. Utility Integrated Resource Planning: An Emerging Driver of NewRenewable Generation in the Western United States

    SciTech Connect (OSTI)

    Bolinger, Mark; Wiser, Ryan

    2005-09-25T23:59:59.000Z

    In the United States, markets for renewable generation--especially wind power--have grown substantially in recent years. This growth is typically attributed to technology improvements and resulting cost reductions, the availability of federal tax incentives, and aggressive state policy efforts. But another less widely recognized driver of new renewable generation is poised to play a major role in the coming years: utility integrated resource planning (IRP). Common in the late-1980s to mid-1990s, but relegated to lesser importance as many states took steps to restructure their electricity markets in the late-1990s, IRP has re-emerged in recent years as an important tool for utilities and regulators, particularly in regions such as the western United States, where retail competition has failed to take root. As practiced in the United States, IRP is a formal process by which utilities analyze the costs, benefits, and risks of all resources available to them--both supply- and demand-side--with the ultimate goal of identifying a portfolio of resources that meets their future needs at lowest cost and/or risk. Though the content of any specific utility IRP is unique, all are built on a common basic framework: (1) development of peak demand and load forecasts; (2) assessment of how these forecasts compare to existing and committed generation resources; (3) identification and characterization of various resource portfolios as candidates to fill a projected resource deficiency; (4) analysis of these different ''candidate'' resource portfolios under base-case and alternative future scenarios; and finally, (5) selection of a preferred portfolio, and creation of a near-term action plan to begin to move towards that portfolio. Renewable resources were once rarely considered seriously in utility IRP. In the western United States, however, the most recent resource plans call for a significant amount of new wind power capacity. These planned additions appear to be motivated by the improved economics of wind power, an emerging understanding that wind integration costs are manageable, and a growing acceptance of wind by electric utilities. Equally important, utility IRPs are increasingly recognizing the inherent risks in fossil-based generation portfolios--especially natural gas price risk and the financial risk of future carbon regulation--and the benefits of renewable energy in mitigating those risks. This article, which is based on a longer report from Berkeley Lab,i examines how twelve investor-owned utilities (IOUs) in the western United States--Avista, Idaho Power, NorthWestern Energy (NWE), Portland General Electric (PGE), Puget Sound Energy (PSE), PacifiCorp, Public Service Company of Colorado (PSCo), Nevada Power, Sierra Pacific, Pacific Gas & Electric (PG&E), Southern California Edison (SCE), and San Diego Gas & Electric (SDG&E)--treat renewable energy in their most recent resource plans (as of July 2005). In aggregate, these twelve utilities supply approximately half of all electricity demand in the western United States. In reviewing these plans, our purpose is twofold: (1) to highlight the growing importance of utility IRP as a current and future driver of renewable generation in the United States, and (2) to suggest possible improvements to the methods used to evaluate renewable generation as a resource option. As such, we begin by summarizing the amount and types of new renewable generation planned as a result of these twelve IRPs. We then offer observations about the IRP process, and how it might be improved to more objectively evaluate renewable resources.

  10. A Protein Export Pathway Involving Escherichia coli Porins

    E-Print Network [OSTI]

    McIntosh, Lawrence P.

    Structure Article A Protein Export Pathway Involving Escherichia coli Porins Gerd Prehna,1,2 Guijin@byron.biochem.ubc.ca (N.C.J.S.) DOI 10.1016/j.str.2012.04.014 SUMMARY Escherichia coli export the protein Yeb common to all E. coli strains has been reported, the mechanism of export has remained unclear. Herein, we

  11. Formation Mechanism for a Hybrid Supramolecular Network Involving Cooperative Interactions

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Formation Mechanism for a Hybrid Supramolecular Network Involving Cooperative Interactions Manuela of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom; CEA, IRAMIS, SPCSI, Hybrid University, 24-29 St Giles, Oxford, OX1 3LB, United Kingdom 4 Department of Materials, University of Oxford

  12. Nuclear Decommissioning and Organisational Reliability: Involving Subcontractors in Collective Action

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Page 1 Nuclear Decommissioning and Organisational Reliability: Involving Subcontractors to the decommissioning. The use of subcontractors is not new; in the nuclear industry it became widespread in the 1990s reliability is at the heart of the safety of at-risk systems. Many studies have been conducted in the nuclear

  13. Research Article Acetylcholinesterase in intestinal cell differentiation involves

    E-Print Network [OSTI]

    Tian, Weidong

    involved in the terminal differentiation of enterocytes. Butyrate, a short-chain fatty acid produced in the colonic lumen by microbial fermentation, is taken up by cells of the intestinal epithelium, and serves of acetylcholine to choline and acetate. Interestingly, the expression of AChE is not restricted to cholinergic

  14. If the internship is international or involves international travel, the

    E-Print Network [OSTI]

    Hart, Gus

    If the internship is international or involves international travel, the student does not need to complete the IRAMS student internship ap- plication, but should contact the Kennedy Center for internship approval and course registration. Flag will be removed, and students will be able to add their internship

  15. If the internship is international or involves international travel, the

    E-Print Network [OSTI]

    Dahl, David B.

    If the internship is international or involves international travel, the student does not need to complete the IRAMS student internship application, but should contact the Kennedy Center for internship approval and course registration. Flag will be removed, and students will be able to add their internship

  16. ORIGINAL PAPER Expression of genes involved in energy mobilization

    E-Print Network [OSTI]

    Lee Jr., Richard E.

    ORIGINAL PAPER Expression of genes involved in energy mobilization and osmoprotectant synthesis, mobilizing carbohydrate energy reserves to promote synthesis of low-molecular-mass osmoprotectants Department of Entomology, Ohio State University, Columbus, OH 43210, USA e-mail: teets.23@osu.edu Y

  17. Hypoxylon mammatum toxins: possible involvement in canker development on aspen

    E-Print Network [OSTI]

    Boyer, Edmond

    Hypoxylon mammatum toxins: possible involvement in canker development on aspen I. Genetet1 J. Pinon a stem canker on aspen (Populus tremula) and on some poplars of the Taca- hamaca section (Pinon, 1976 inhibited callus formation in wounds on aspen bark. Schipper (1978) and Ster- mer et aL, (1984) confirmed

  18. Mechanism of heterogeneous catalytic reactions involving molecular hydrogen

    SciTech Connect (OSTI)

    Golodets, G.I.

    1987-07-01T23:59:59.000Z

    By means of various physicochemical methods, including kinetics, the mechanism of a series of reactions involving molecular H/sub 2/ (the hydrogenation of carbonyl compounds, nitriles, carbon monoxide, molecular nitrogen, and oxygen) on metallic catalysts of different chemical compositions and degrees of dispersion has been investigated. Some general laws for reactions of this class are formulated.

  19. Argonne National Laboratory has been actively involved in the development

    E-Print Network [OSTI]

    Kemner, Ken

    Argonne National Laboratory has been actively involved in the development of advanced batteries at Argonne and named it the National Battery Test Laboratory (NBTL), for the purpose of conducting in these early days of the battery program, Argonne was internationally respected for its advanced battery work

  20. LESSONS LEARNED FROM AN IMPOUNDMENT SLOPE FAILURE INVOLVING GEOSYNTHETICS

    E-Print Network [OSTI]

    failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment. KEYWORDS: Geosynthetic clay liners, Interface Shear Strength, Waste containment, Strength, Stability to illustrate the importance of (i) properly storing geosynthetic clay liners (GCLs) to reduce the amount

  1. On some arithmetic properties of polynomial expressions involving Stirling numbers

    E-Print Network [OSTI]

    Klazar, Martin

    On some arithmetic properties of polynomial expressions involving Stirling numbers of the second by the grant SEP-CONACYT 37259-E. 1 #12;Abstract Let S(n, k) be the classical Stirling numbers of the second. We give similar but more particular results on the more general Stirling-like numbers T(n, k). 2 #12

  2. DEVELOPMENT AND USE OF A DIRECTORY OF ACCIDENT DATABASES INVOLVING

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    DEVELOPMENT AND USE OF A DIRECTORY OF ACCIDENT DATABASES INVOLVING CHEMICALS J.P.Pineau Institut from end-users of accident data who need validated data for dealing with risk assessment in which Data collection Data analysis, Reliability, Uncertainty, Accident, Hazardous material, Risk analysis

  3. Chapter citation (as of Dec., 2012): Barber, S. J., & Mather, M. (in press). Stereotype threat in older adults: When and why

    E-Print Network [OSTI]

    Mather, Mara

    Chapter citation (as of Dec., 2012): Barber, S. J., & Mather, M. (in press). Stereotype threat threat in older adults: When and why does it occur and who is most affected? Author Names: Sarah J: barbersa@usc.edu Abstract: Stereotype threat occurs when people fear that poor performance on their part

  4. Unplanned, urgent and emergency care: what are the roles EMS provide for older people with dementia? An integrative review of policy, professional recommendations and evidence

    E-Print Network [OSTI]

    Buswell, Marina; Lumbard, Philip; Prothero, Larissa; Lee, Caroline; Martin, Steven; Fleming, Jane; Goodman, Claire

    2015-01-01T23:59:59.000Z

    , et al. Dementia as a Risk Factor for Falls and Fall Injuries Among Nursing Home Residents. J Am Geriatr Soc. 2003;51(9):1213-8. 14. Allan LM, Ballard CG, Rowan EN, et al. Incidence and Prediction of Falls in Dementia: A Prospective Study in Older...

  5. Drivers and Directions

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    per day Marine Rail Cars Air Light Trucks Heavy Trucks U.S. Production Off-Road U.S. Petroleum Production and Consumption, 1970-2030 Actual Projected Source: TEDB No. 26 and...

  6. Drivers of melanoma susceptibility

    E-Print Network [OSTI]

    Robles Espinoza, Carla Daniela

    2015-03-03T23:59:59.000Z

    different time zones. I would like to acknowledge the Wellcome Trust and the Consejo Nacional de Ciencia y Tecnología of Mexico, my funding bodies, for making sure I was not homeless and 8hungry during these last years, and for trusting in me. This work...

  7. Market Drivers for Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment3311, 3312), October 2012 (MECSEnergy PlansMaterials forBuilding

  8. Optimizing and Diversifying the Electric Range of Plug-in Hybrid Electric Vehicles for U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong [ORNL

    2012-01-01T23:59:59.000Z

    To provide useful information for automakers to design successful plug-in hybrid electric vehicle (PHEV) products and for energy and environmental analysts to understand the social impact of PHEVs, this paper addresses the question of how many of the U.S. consumers, if buying a PHEV, would prefer what electric ranges. The Market-oriented Optimal Range for PHEV (MOR-PHEV) model is developed to optimize the PHEV electric range for each of 36,664 sampled individuals representing U.S. new vehicle drivers. The optimization objective is the minimization of the sum of costs on battery, gasoline, electricity and refueling hassle. Assuming no battery subsidy, the empirical results suggest that: 1) the optimal PHEV electric range approximates two thirds of one s typical daily driving distance in the near term, defined as $450/kWh battery delivered price and $4/gallon gasoline price. 2) PHEVs are not ready to directly compete with HEVs at today s situation, defined by the $600/kWh battery delivered price and the $3-$4/gallon gasoline price, but can do so in the near term. 3) PHEV10s will be favored by the market over longer-range PHEVs in the near term, but longer-range PHEVs can dominate the PHEV market if gasoline prices reach as high as $5-$6 per gallon and/or battery delivered prices reach as low as $150-$300/kWh. 4) PHEVs can become much more attractive against HEVs in the near term if the electric range can be extended by only 10% with multiple charges per day, possible with improved charging infrastructure or adapted charging behavior. 5) the impact of a $100/kWh decrease in battery delivered prices on the competiveness of PHEVs against HEVs can be offset by about $1.25/gallon decrease in gasoline prices, or about 7/kWh increase in electricity prices. This also means that the impact of a $1/gallon decrease in gasoline prices can be offset by about 5/kWh decrease in electricity prices.

  9. Botryllus schlosseri (Tunicata) whole colony irradiation: Do senescent zooid resorption and immunological resorption involve similar recognition events

    SciTech Connect (OSTI)

    Rinkevich, B.; Weissman, I.L. (Israel Oceanographic and Limnological Research, Haifa (Israel))

    1990-02-01T23:59:59.000Z

    The colonial tunicate Botryllus schlosseri undergoes cyclic blastogenesis where feeding zooids are senescened and resorbed and a new generation of zooids takes over the colony. When non-identical colonies come into direct contact, they either reject each other or fuse. Fusion is usually followed by the resorption of one of the partners in the chimera (immunological resorption). The striking morphological similarities between the two resorption phenomena suggest that both may involve tissue destruction following self-nonself recognition events. Here we attempt to modify these two events by whole colony gamma irradiation assays. Three sets of experiments were performed: (1) different doses of whole colony irradiation for determination of irradiation effects (110 colonies); (2) pairs of irradiated-nonirradiated isografts of clonal replicates for the potential of reconstruction of the irradiated partners (23 pairs); (3) chimeras of irradiated-nonirradiated partners for analysis of resorption hierarchy. Mortality increased with the irradiation dose. All colonies exposed to more than 5,000 rads died within 19 days, while no colony died below 2,000 rads. The average mortality periods, in days, for doses of 6,000-8,000, 5,000, and 2,500-4,000 rads were 14.4 +/- 3.1 (n = 24), 19.8 +/- 6.0 (n = 15), and 19.6 + 5.1 (n = 22), respectively. Younger colonies (3-6 months old) may survive radiation better than older ones (more than 13 months). Many morphological alterations were recorded in irradiated colonies: ampullar contraction and/or dilation, accumulation of pigment cells within ampullae, abnormal bleeding from blood vessels, sluggish blood circulation, necrotic zones, reduction in bud number, and irregularities in zooid and system structures. With doses of 3,000-4,000 rads and above, irradiation arrested the formation of new buds and interrupted normal takeover.

  10. Department of Transportation I. Internal Scan

    E-Print Network [OSTI]

    Tipple, Brett

    Department of Transportation I. Internal Scan The number of older drivers in the United States-driver basis, older adults are among the safest. The average annual number of crashes in the United States million vehicle miles traveled (MVMT), drivers over the age of 75 have a fatality rate of 3.7 deaths per

  11. Get Involved with Home Energy Score | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers3.pdf0-45.pdf0 Budget FossilGeothermalGeothermal developersGet Involved with

  12. NEPA-Related Public Involvement | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagement of theTechno-economicOctober 2013NEPA-Related Public Involvement

  13. Get Involved with Home Energy Score | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdf Flash2006-52.pdf0.pdfDepartmentCounsel LawDemonstrationDepartmentGet Involved with

  14. COMPASS Hadron Spectroscopy -- Final states involving neutrals and kaons

    E-Print Network [OSTI]

    Frank Nerling; for the COMPASS collaboration

    2010-09-11T23:59:59.000Z

    The COMPASS experiment at CERN is well designed for light-hadron spectroscopy with emphasis on the detection of new states, in particular the search for $J^{PC}$-exotic states and glueballs. We have collected data with 190 GeV/c charged hadron beams on a liquid hydrogen and nuclear targets in 2008/09. The spectrometer features good coverage by electromagnetic calorimetry and a RICH detector further provides $\\pi$ / $K$ separation, allowing for studying final states involving neutral particles like $\\pi^0$ or $\\eta$ as well as hidden strangeness, respectively. We discuss the status of ongoing analyses with specific focus on diffractively produced $(\\pi^0\\pi^0\\pi)^{-}$ as well as $(K\\bar{K}\\pi)^{-}$ final states.

  15. Attitudes to ageing : a systematic review of attitudes to ageing and mental health, and a cross-sectional analysis of attitudes to ageing and quality of life in older adults 

    E-Print Network [OSTI]

    Long, Sarah Charlotte May

    2014-07-01T23:59:59.000Z

    This thesis portfolio examines attitudes to ageing in older adults, and explores the impact that attitudes to ageing have on mental health status and quality of life. Attitudes to ageing are becoming more widely measured ...

  16. Late-life depression : a systematic review of meta-analyses and a meta-analysis of the effect of cognitive behavioural therapy in older adults with co-morbid physical illness 

    E-Print Network [OSTI]

    Huxtable, David

    2013-07-02T23:59:59.000Z

    Aims: To examine the efficacy of CBT for late-life depression in older adults with co-morbid physical illness and to review what has been revealed by meta-analytic studies with regards moderators of treatment in psychological ...

  17. Patterns of Care and Locoregional Treatment Outcomes in Older Esophageal Cancer Patients: The SEER-Medicare Cohort

    SciTech Connect (OSTI)

    Smith, Grace L. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Smith, Benjamin D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Radiation Oncology Flight, Wilford Hall Medical Center, San Antonio, TX (United States); Buchholz, Thomas A.; Liao Zhongxing; Jeter, Melenda [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Swisher, Stephen G. M.D.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); McAleer, Mary F.; Komaki, Ritsuko [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Cox, James D. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: jcox@mdanderson.org

    2009-06-01T23:59:59.000Z

    Purpose: Optimal management of elderly patients with nonmetastatic esophageal cancer is unclear. Outcomes data after locoregional treatment are lacking for this group. Methods: We assessed outcomes associated with standard locoregional treatments in 2,626 patients (age > 65 years) from the Surveillance Epidemiology and End Results (SEER)-Medicare cohort diagnosed with nonmetastatic esophageal cancer from 1992 to 2002. In patients treated with radiotherapy alone (RT), surgery alone (S), chemoradiotherapy (CRT), or preoperative chemotherapy followed by surgery (CRT + S), overall and disease-free survival were compared using proportional hazards regression. Postoperative complications were compared using logistic regression. Results: Mean age was 76 {+-} 6 years. Seven percent underwent CRT + S, 39% CRT, 30% S, and 24% RT. One-year survival was 68% (CRT + S), 52% (CRT), 53% (S), and 16% (RT), respectively (p < 0.001). Patients who underwent CRT + S demonstrated improved overall survival compared with S alone (hazard ratio [HR] = 0.81; 95% confidence interval [CI], 0.66-0.98; p = 0.03) and RT (HR = 0.44; 95% CI, 0.35-0.55; p < 0.0001); and comparable survival to CRT (HR = 0.82; 95% CI, 0.67-1.01; p = 0.06). Patients who underwent CRT + S also had comparable postoperative mortality (HR = 0.96; 95% CI, 0.87-1.07; p = 0.45) and complications (OR = 0.89; 95% CI, 0.70-1.14; p = 0.36) compared with S alone. Conclusions: Preoperative chemoradiotherapy may be an acceptable treatment option in appropriately selected older esophageal cancer patients. This treatment modality did not appear to increase surgical complications and offered potential therapeutic benefit, particularly compared with surgery alone.

  18. Land-use transition for bioenergy and climate stabilization: model comparison of drivers, impacts and interactions with other land use based mitigation options

    SciTech Connect (OSTI)

    Popp, Alexander; Rose, Steven K.; Calvin, Katherine V.; Van Vuuren, Detlef; Dietrich, Jan P.; Wise, Marshall A.; Stehfest, Eike; Humpenoder, Florian; Kyle, G. Page; Van Vliet, Jasper; Bauer, Nico; Lotze-Campen, Hermann; Klein, David; Kriegler, Elmar

    2014-04-01T23:59:59.000Z

    This study is a model comparison assessing the drivers and impacts of bioenergy production on the global land system and the interaction with other land use based mitigation options in the context of the EMF 27 project. We compare and evaluate results from three integrated assessment models (GCAM, IMAGE, and ReMIND/MAgPIE). All three models project that dedicated bioenergy crops and biomass residues are a potentially important and cost-effective component of the energy system. But bioenergy deployment levels and feedstock composition vary notably across models as do the implications for land-use and greenhouse gas emissions and the interaction with other land use based mitigation measures. Despite numerous model differences, we identify a few that are likely contributing to differences in land-use and emissions attributable to energy crop deployment.

  19. A Polysilicon Active Matrix Organic Light Emitting Diode Display with Integrated Drivers R.M.A. Dawson, Z. Shen, D.A. Furst, S. Connor, J. Hsu, M.G. Kane, R.G. Stewart, A. Ipri

    E-Print Network [OSTI]

    A Polysilicon Active Matrix Organic Light Emitting Diode Display with Integrated Drivers R.S.A. Abstract The design of an active matrix organic light emitting diode (AMOLED) display using a polysilicon. Introduction Organic light emitting diodes (OLEDs) are presently of great interest due to their potential

  20. Personnel involved in nuclear standards development: 1980 directory

    SciTech Connect (OSTI)

    Carr, S.J. (ed.)

    1980-03-01T23:59:59.000Z

    The development of nuclear standards is an active and necessary endeavor that is concerned with the safe, orderly, and economic development of nuclear potential. There are almost 4100 people from the teachnical community who are presently involved either in writing nuclear standards, including codes, or in the management and processing roles necessary for their approval and promulgation. This document identifies the current participation of each individual as member, chairman, cochairman (vice-chairman), or secretary of about 700 standards development committees and groups. The standards committees and groups are identified with the organizations that are responsible for the preparation, review, and maintenance of the standards and that provide support through supervisory committees and headquarters staff. This directory includes four major sections: personnel, employers, committees, and a Key-Word-in-Context (KWIC) Index of committee titles. It can also be used to identify the participation of employers as well as to recognize the contributions of individuals to the often interdisciplinary activity of standards development.

  1. Representation of analysis results involving aleatory and epistemic uncertainty.

    SciTech Connect (OSTI)

    Johnson, Jay Dean (ProStat, Mesa, AZ); Helton, Jon Craig (Arizona State University, Tempe, AZ); Oberkampf, William Louis; Sallaberry, Cedric J.

    2008-08-01T23:59:59.000Z

    Procedures are described for the representation of results in analyses that involve both aleatory uncertainty and epistemic uncertainty, with aleatory uncertainty deriving from an inherent randomness in the behavior of the system under study and epistemic uncertainty deriving from a lack of knowledge about the appropriate values to use for quantities that are assumed to have fixed but poorly known values in the context of a specific study. Aleatory uncertainty is usually represented with probability and leads to cumulative distribution functions (CDFs) or complementary cumulative distribution functions (CCDFs) for analysis results of interest. Several mathematical structures are available for the representation of epistemic uncertainty, including interval analysis, possibility theory, evidence theory and probability theory. In the presence of epistemic uncertainty, there is not a single CDF or CCDF for a given analysis result. Rather, there is a family of CDFs and a corresponding family of CCDFs that derive from epistemic uncertainty and have an uncertainty structure that derives from the particular uncertainty structure (i.e., interval analysis, possibility theory, evidence theory, probability theory) used to represent epistemic uncertainty. Graphical formats for the representation of epistemic uncertainty in families of CDFs and CCDFs are investigated and presented for the indicated characterizations of epistemic uncertainty.

  2. Parametic Study of the current limit within a single driver-scaletransport beam line of an induction Linac for Heavy Ion Fusion

    SciTech Connect (OSTI)

    Prost, Lionel Robert

    2007-02-14T23:59:59.000Z

    The High Current Experiment (HCX) at Lawrence Berkeley National Laboratory is part of the US program that explores heavy-ion beam as the driver option for fusion energy production in an Inertial Fusion Energy (IFE) plant. The HCX is a beam transport experiment at a scale representative of the low-energy end of an induction linear accelerator driver. The primary mission of this experiment is to investigate aperture fill factors acceptable for the transport of space-charge-dominated heavy-ion beams at high intensity (line charge density {approx}0.2 {micro}C/m) over long pulse durations (4 {micro}s) in alternating gradient focusing lattices of electrostatic or magnetic quadrupoles. This experiment is testing transport issues resulting from nonlinear space-charge effects and collective modes, beam centroid alignment and steering, envelope matching, image charges and focusing field nonlinearities, halo and, electron and gas cloud effects. We present the results for a coasting 1 MeV K{sup +} ion beam transported through ten electrostatic quadrupoles. The measurements cover two different fill factor studies (60% and 80% of the clear aperture radius) for which the transverse phase-space of the beam was characterized in detail, along with beam energy measurements and the first halo measurements. Electrostatic quadrupole transport at high beam fill factor ({approx}80%) is achieved with acceptable emittance growth and beam loss. We achieved good envelope control, and re-matching may only be needed every ten lattice periods (at 80% fill factor) in a longer lattice of similar design. We also show that understanding and controlling the time dependence of the envelope parameters is critical to achieving high fill factors, notably because of the injector and matching section dynamics.

  3. Surface interactions involved in flashover with high density electronegative gases.

    SciTech Connect (OSTI)

    Hodge, Keith Conquest; Warne, Larry Kevin; Jorgenson, Roy Eberhardt; Wallace, Zachariah Red; Lehr, Jane Marie

    2010-01-01T23:59:59.000Z

    This report examines the interactions involved with flashover along a surface in high density electronegative gases. The focus is on fast ionization processes rather than the later time ionic drift or thermalization of the discharge. A kinetic simulation of the gas and surface is used to examine electron multiplication and includes gas collision, excitation and ionization, and attachment processes, gas photoionization and surface photoemission processes, as well as surface attachment. These rates are then used in a 1.5D fluid ionization wave (streamer) model to study streamer propagation with and without the surface in air and in SF6. The 1.5D model therefore includes rates for all these processes. To get a better estimate for the behavior of the radius we have studied radial expansion of the streamer in air and in SF6. The focus of the modeling is on voltage and field level changes (with and without a surface) rather than secondary effects, such as, velocities or changes in discharge path. An experiment has been set up to carry out measurements of threshold voltages, streamer velocities, and other discharge characteristics. This setup includes both electrical and photographic diagnostics (streak and framing cameras). We have observed little change in critical field levels (where avalanche multiplication sets in) in the gas alone versus with the surface. Comparisons between model calculations and experimental measurements are in agreement with this. We have examined streamer sustaining fields (field which maintains ionization wave propagation) in the gas and on the surface. Agreement of the gas levels with available literature is good and agreement between experiment and calculation is good also. Model calculations do not indicate much difference between the gas alone versus the surface levels. Experiments have identified differences in velocity between streamers on the surface and in the gas alone (the surface values being larger).

  4. Governance, participation and avoidance: everyday public involvement in the Scottish NHS 

    E-Print Network [OSTI]

    Stewart, Ellen Anderson

    2012-06-29T23:59:59.000Z

    Public involvement in health services is an area of policy where ostensibly good intentions appear to repeatedly fail in implementation. Since the late 1990s public involvement in the UK NHS has been subject to frequent ...

  5. Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development and Sulfur Metabolism. Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development and Sulfur...

  6. Application of Dissolution Dynamic Nuclear Polarization to the Characterization of Reactions Involving Large Molecules

    E-Print Network [OSTI]

    Lee, Youngbok

    2013-03-13T23:59:59.000Z

    aims to extend the applicability of D-DNP into new areas of chemistry, which involve the characterization of interactions and reactions involving large molecules. In a first project, fluorine hyperpolarization is exploited to investigate protein...

  7. Influence of microwave driver coupling design on plasma density at Testbench for Ion sources Plasma Studies, a 2.45 GHz Electron Cyclotron Resonance Plasma Reactor

    SciTech Connect (OSTI)

    Megía-Macías, A.; Vizcaíno-de-Julián, A. [E.S.S. Bilbao, Edificio Cosimet, Landabarri 2, 48940-Leioa, Vizcaya (Spain)] [E.S.S. Bilbao, Edificio Cosimet, Landabarri 2, 48940-Leioa, Vizcaya (Spain); Cortázar, O. D., E-mail: dcortazar@essbilbao.org [E.S.S. Bilbao, Edificio Cosimet, Landabarri 2, 48940-Leioa, Vizcaya (Spain); Universidad de Castilla-La Mancha, ETSII, C.J. Cela s/n, 13170 Ciudad Real (Spain)

    2014-03-15T23:59:59.000Z

    A comparative study of two microwave driver systems (preliminary and optimized) for a 2.45 GHz hydrogen Electron Cyclotron Resonance plasma generator has been conducted. The influence on plasma behavior and parameters of stationary electric field distribution in vacuum, i.e., just before breakdown, along all the microwave excitation system is analyzed. 3D simulations of resonant stationary electric field distributions, 2D simulations of external magnetic field mapping, experimental measurements of incoming and reflected power, and electron temperature and density along the plasma chamber axis have been carried out. By using these tools, an optimized set of plasma chamber and microwave coupler has been designed paying special attention to the optimization of stationary electric field value in the center of the plasma chamber. This system shows a strong stability on plasma behavior allowing a wider range of operational parameters and even sustaining low density plasma formation without external magnetic field. In addition, the optimized system shows the capability to produce values of plasma density four times higher than the preliminary as a consequence of a deeper penetration of the magnetic resonance surface in relative high electric field zone by keeping plasma stability. The increment of the amount of resonance surface embedded in the plasma under high electric field is suggested as a key factor.

  8. A prototype 7.5 MHz Finemet(Trademark) loaded RF cavity and 200kW amplifier for the Fermilab proton driver

    SciTech Connect (OSTI)

    David W. Wildman et al.

    2001-07-09T23:59:59.000Z

    A 7.5 MHz RF cavity and power amplifier have been built and tested at Fermilab as part of the proton Driver Design Study. The project goal was to achieve the highest possible 7.5 MHz accelerating gradient at 15 Hz with a 50% duty cycle. To reduce beam loading effects, a low shunt impedance (500{Omega}) design was chosen. The 46 cm long single gap cavity uses 5 inductive cores, consisting of the nanocrystalline soft magnetic alloy Finemet, to achieve a peak accelerating voltage of 15 kV. The 95 cm OD tape wound cores have been cut in half to increase the cavity Q and are cooled from both sides using large water-cooled copper heat sinks. The prototype cavity has a shunt impedance of 550{Omega}, Q = 11, and is powered by a 200 kW cw cathode driven tetrode amplifier. Both cavity and amplifier designs are described. Results from recent cavity tests coalescing beam in the Fermilab Main Injector is also presented.

  9. The effects of school gardening on parent involvement in elementary schools

    E-Print Network [OSTI]

    Boyer, Roxanne Christina

    2002-01-01T23:59:59.000Z

    to helping with schoolwork at home (Henderson et al. , 1986). Some researchers divide types of involvement according to where it occurs such as in the home?school, or community (NCES, 1997). Others define parent involvement according to how... in parenting, communicating, volunteering, learning at home, decision making, and collaborating with the community (Epstein, 1995). Henderson and others (1986) define parent involvement in terms of the roles that parents have in education such as partners...

  10. Molecular genetic analysis of activation-tagged transcription factors thought to be involved in photomorphogenesis

    SciTech Connect (OSTI)

    Neff, Michael M.

    2011-06-23T23:59:59.000Z

    This is a final report for Department of Energy Grant No. DE-FG02-08ER15927 entitled “Molecular Genetic Analysis of Activation-Tagged Transcription Factors Thought to be Involved in Photomorphogenesis”. Based on our preliminary photobiological and genetic analysis of the sob1-D mutant, we hypothesized that OBP3 is a transcription factor involved in both phytochrome and cryptochrome-mediated signal transduction. In addition, we hypothesized that OBP3 is involved in auxin signaling and root development. Based on our preliminary photobiological and genetic analysis of the sob2-D mutant, we also hypothesized that a related gene, LEP, is involved in hormone signaling and seedling development.

  11. aopex11-1 gene involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  12. antagonist labedipinedilol-a involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  13. aeruginosa w51d involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  14. analysis involving tvs-m: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  15. acetobutylicum involving non-coding: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  16. arene di-oxygenases involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  17. Study of instability formation and EUV emission in thin liners driven with a compact 250?kA, 150?ns linear transformer driver

    SciTech Connect (OSTI)

    Valenzuela, J. C., E-mail: jcval@ucsd.edu; Collins, G. W.; Mariscal, D.; Beg, F. N. [Center for Energy Research, University of California San Diego, La Jolla, California 92093 (United States)] [Center for Energy Research, University of California San Diego, La Jolla, California 92093 (United States); Wyndham, E. S. [Facultad de Física, Pontificia Universidad Católica de Chile, Ave. Vicuña Mackena 4860, Macul, Santiago (Chile)] [Facultad de Física, Pontificia Universidad Católica de Chile, Ave. Vicuña Mackena 4860, Macul, Santiago (Chile)

    2014-03-15T23:59:59.000Z

    A compact linear transformer driver, capable of producing 250?kA in 150?ns, was used to study instability formation on the surface of thin liners. In the experiments, two different materials, Cu and Ni, were used to study the effect of the liner's resistivity on formation and evolution of the instabilities. The dimensions of the liners used were 7?mm height, 1?mm radius, and 3??m thickness. Laser probing and time resolved extreme ultraviolet (EUV) imaging were implemented to diagnose instability formation and growth. Time-integrated EUV spectroscopy was used to study plasma temperature and density. A constant expansion rate for the liners was observed, with similar values for both materials. Noticeable differences were found between the Cu and Ni instability growth rates. The most significant perturbation in Cu rapidly grows and saturates reaching a limiting wavelength of the order of the liner radius, while the most significant wavelength in Ni increases slowly before saturating, also at a wavelength close to the liner radius. Evidence suggests that the instability observed is the well-known m?=?0 MHD instability. However, upon comparing the instability evolution of Cu and Ni, the importance of the resistivity on the seeding mechanism becomes evident. A comparison of end-on and side-on EUV emission possible indicates the formation of precursor plasma, where it has been estimated using EUV spectroscopy that the precursor plasma temperature is approximately 40?eV with ion density of order 10{sup 19}?cm{sup ?3}, for both materials.

  18. Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

    SciTech Connect (OSTI)

    Diaz, Dolores, E-mail: diaz.dolores@gene.com [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Ford, Kevin A. [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Hartley, Dylan P. [Array Biopharma, Boulder, CO (United States)] [Array Biopharma, Boulder, CO (United States); Harstad, Eric B.; Cain, Gary R.; Achilles-Poon, Kirsten; Nguyen, Trung [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Peng, Jing; Zheng, Zhong; Merchant, Mark [Translation Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Translation Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Sutherlin, Daniel P. [Medicinal Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Medicinal Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Gaudino, John J.; Kaus, Robert [Array Biopharma, Boulder, CO (United States)] [Array Biopharma, Boulder, CO (United States); Lewin-Koh, Sock C. [Biostatistics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Biostatistics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Choo, Edna F.; Liederer, Bianca M. [Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States); Dambach, Donna M. [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)] [Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080 (United States)

    2013-01-01T23:59:59.000Z

    Several toxicities are clearly driven by free drug concentrations in plasma, such as toxicities related to on-target exaggerated pharmacology or off-target pharmacological activity associated with receptors, enzymes or ion channels. However, there are examples in which organ toxicities appear to correlate better with total drug concentrations in the target tissues, rather than with free drug concentrations in plasma. Here we present a case study in which a small molecule Met inhibitor, GEN-203, with significant liver and bone marrow toxicity in preclinical species was modified with the intention of increasing the safety margin. GEN-203 is a lipophilic weak base as demonstrated by its physicochemical and structural properties: high LogD (distribution coefficient) (4.3) and high measured pKa (7.45) due to the basic amine (N-ethyl-3-fluoro-4-aminopiperidine). The physicochemical properties of GEN-203 were hypothesized to drive the high distribution of this compound to tissues as evidenced by a moderately-high volume of distribution (Vd > 3 l/kg) in mouse and subsequent toxicities of the compound. Specifically, the basicity of GEN-203 was decreased through addition of a second fluorine in the 3-position of the aminopiperidine to yield GEN-890 (N-ethyl-3,3-difluoro-4-aminopiperidine), which decreased the volume of distribution of the compound in mouse (Vd = 1.0 l/kg), decreased its tissue drug concentrations and led to decreased toxicity in mice. This strategy suggests that when toxicity is driven by tissue drug concentrations, optimization of the physicochemical parameters that drive tissue distribution can result in decreased drug concentrations in tissues, resulting in lower toxicity and improved safety margins. -- Highlights: ? Lower pKa for a small molecule: reduced tissue drug levels and toxicity. ? New analysis tools to assess electrostatic effects and ionization are presented. ? Chemical and PK drivers of toxicity can be leveraged to improve safety.

  19. Customer Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would likeConstitution4Customer-Comments Sign In About | Careers |

  20. Getting Involved

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental AssessmentsGeoffrey

  1. Unravelling aspects of the gas phase chemistry involved in diamond chemical vapour deposition

    E-Print Network [OSTI]

    Bristol, University of

    of thin Ðlms of polycrystalline diamond by chemi- cal vapour deposition (CVD) methods,2h4 since which timeUnravelling aspects of the gas phase chemistry involved in diamond chemical vapour deposition been used to unravel details of the gas phase chemistry involved in diamond chemical vapour deposition

  2. Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast

    E-Print Network [OSTI]

    Wang, Y.Q. "Yeqiao"

    Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast.1080/08920750590883132 Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast YEQIAO WANG and the area of woodland interspersed with agriculture increased. This study demonstrates how geospatial

  3. New Developments involving the Stream Health Index for the Puget Sound Lowland

    E-Print Network [OSTI]

    Washington at Seattle, University of

    New Developments involving the Stream Health Index for the Puget Sound Lowland Grace Chiu Peter and ecological sciences. #12;#12;Full title: New Developments involving the Stream Health Index for the Puget;SUMMARY Since the introduction of the stream health index for the Puget Sound Lowland (SHIPSL) (Chiu

  4. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

    E-Print Network [OSTI]

    Quirk, Gregory J.

    experiments designed to bridge human and rodent models of emotion regulation. Addresses 1 Department of prefrontal involvement of emotion regula- tion using rat and human models, and suggest future experimentsPrefrontal involvement in the regulation of emotion: convergence of rat and human studies Gregory J

  5. ORIGINAL PAPER On the Role of the Difference in Surface Tensions Involved

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER On the Role of the Difference in Surface Tensions Involved in the Allosteric was to develop the relationship between membrane surface tension, and the allosteric balance in a difference in surface tensions that is involved in the creation of a reservoir of intracellular vesicles

  6. Figure 1.-The older commercial-type dredge was usually of two-piece con-struction as clammers felt it tended bottom better. It was also easier to handle over

    E-Print Network [OSTI]

    Figure 1.-The older commercial-type dredge was usually of two-piece con- struction as clammers felt. NULK Rear cage Chain bag I Basic Concept Development The dredge system in use at the time the choice was made to go to a new survey was a 48- inch (122 em) surface- supplied hydraulic dredge (Fig. 2

  7. What is the effect of 4-H involvement on levels of empathy, self-esteem, community involvement and positive view of the future on urban youth?

    E-Print Network [OSTI]

    Bonnett, Erika Dawn

    2007-04-25T23:59:59.000Z

    , self-esteem, positive view of the future, and community involvement. The study utilized a quantitative research model in which a survey was taken of youth presiding in urban areas in the state of Texas. Descriptive statistics were used to report subject...

  8. Dosimetric and Clinical Outcomes of Involved-Field Intensity-Modulated Radiotherapy After Chemotherapy for Early-Stage Hodgkin's Lymphoma With Mediastinal Involvement

    SciTech Connect (OSTI)

    Lu Ningning [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Li Yexiong, E-mail: yexiong@yahoo.com [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Wu Runye; Zhang Ximei; Wang Weihu; Jin Jing; Song Yongwen; Fang Hui; Ren Hua; Wang Shulian; Liu Yueping; Liu Xinfan; Chen Bo; Dai Jianrong; Yu Zihao [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)

    2012-09-01T23:59:59.000Z

    Purpose: To evaluate the dosimetric and clinical outcomes of involved-field intensity-modulated radiotherapy (IF-IMRT) for patients with early-stage Hodgkin's lymphoma (HL) with mediastinal involvement. Methods and Materials: Fifty-two patients with early-stage HL that involved the mediastinum were reviewed. Eight patients had Stage I disease, and 44 patients had Stage II disease. Twenty-three patients (44%) presented with a bulky mediastinum, whereas 42 patients (81%) had involvement of both the mediastinum and either cervical or axillary nodes. All patients received combination chemotherapy followed by IF-IMRT. The prescribed radiation dose was 30-40 Gy. The dose-volume histograms of the target volume and critical normal structures were evaluated. Results: The median mean dose to the primary involved regions (planning target volume, PTV1) and boost area (PTV2) was 37.5 Gy and 42.1 Gy, respectively. Only 0.4% and 1.3% of the PTV1 and 0.1% and 0.5% of the PTV2 received less than 90% and 95% of the prescribed dose, indicating excellent PTV coverage. The median mean lung dose and V20 to the lungs were 13.8 Gy and 25.9%, respectively. The 3-year overall survival, local control, and progression-free survival rates were 100%, 97.9%, and 96%, respectively. No Grade 4 or 5 acute or late toxicities were reported. Conclusions: Despite the large target volume, IF-IMRT gave excellent dose coverage and a favorable prognosis, with mild toxicity in patients with early-stage mediastinal HL.

  9. Ranacyclins, a New Family of Short Cyclic Antimicrobial Peptides: Biological Function, Mode of Action, and Parameters Involved in Target Specificity,,@

    E-Print Network [OSTI]

    Pompeu Fabra, Universitat

    of Action, and Parameters Involved in Target Specificity,,@ M. Luisa Mangoni, Niv Papo,§ Giuseppina Mignogna

  10. Accelerating Alternatives for Minnesota Drivers

    Broader source: Energy.gov (indexed) [DOE]

    Energy * Xcel Energy Other * American Lung Association in Minnesota * Boyer Ford * Eaton Corporation * Environmental Initiative * PlugInConnect * University of Minnesota -...

  11. Community Engagement as a Driver

    Broader source: Energy.gov [DOE]

    Presents the outreach approaches used by New Jersey's Clean Energy Program, as well as the lessons learned from various types of leads.

  12. Regulatory Drivers | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR -Department of Energyas ofCheniere

  13. Undergraduate business and management students’ experiences of being involved in assessment 

    E-Print Network [OSTI]

    Tai, Chunming

    2012-11-29T23:59:59.000Z

    This study aimed to explore university undergraduates’ experiences of student involvement in assessment (SIA). Based on Biggs’ 3P model of student learning, this study focused on students’ experiences prior to SIA, during ...

  14. The role of involvement and commitment in explaining intention to engage in birding trips

    E-Print Network [OSTI]

    Kim, Seong-Seop

    1996-01-01T23:59:59.000Z

    -psychological involvement measures, and measures of commitment; (c) to ascertain how well Laurent and Kapferer's (1985) scale, Zaichkowsky's (1985) scale, a set of behavioral measures, and commitment nimures explain intention to go on birding trips; (4) to conceptualize...

  15. A study of parental involvement and school climate: Perspective from the middle school

    E-Print Network [OSTI]

    Dixon, Shantina Rayford

    2009-05-15T23:59:59.000Z

    This study examines school level differences on different dimensions of teacherrated parent involvement and school climate while adjusting for age, gender, ethnicity, how certified, and number of years teaching. Two hundred twenty-four elementary...

  16. School-Based Family Involvement: Patterns and Predictors in the NLTS2

    E-Print Network [OSTI]

    Frew, Leigh Ann

    2012-10-19T23:59:59.000Z

    This investigation used data from the National Longitudinal Transition Study 2 (NLTS2) to investigate patterns among student, family, and school characteristics, school outreach programs, and school-based family involvement for families of 5...

  17. Examination of offsite radiological emergency protective measures for nuclear reactor accidents involving core melt

    E-Print Network [OSTI]

    Aldrich, David C.

    1979-01-01T23:59:59.000Z

    Evacuation, sheltering followed by population relocation, and iodine prophylaxis are evaluated as offsite public protective measures in response to nuclear reactor accidents involving core-melt. Evaluations were conducted ...

  18. Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir

    E-Print Network [OSTI]

    Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir B. Pande-Oregon region, and 684 SNPs were identified in total. We report the estimation of nucleotide diversity and tests

  19. Use of associated polynomials for division involving polynomials over arbitrary fields

    E-Print Network [OSTI]

    Jones, James Edgar

    1968-01-01T23:59:59.000Z

    USE OF ASSOCIATED POLYNOMIALS FOR DIVISION INVOLVING POLYNOMIALS OVER ARBITRARY FIELDS A Thesis by JAMES EDGAR JOiVES Submitted to the Graduate College of the Texas A&M University in partiai fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1968 Major Subject: MATHEJRTICS USE OF ASSOCIATED POLYNOMIALS FOR DIVISION INVOLVING POLYNOMIALS OVER ARBITRARY FIELDS A Thesis by JAMES EDGAR JONES Approved as to style and content by (Chairman of Committee) (Head...

  20. Older Age Predicts Decreased Metastasis and Prostate Cancer-Specific Death for Men Treated With Radiation Therapy: Meta-Analysis of Radiation Therapy Oncology Group Trials

    SciTech Connect (OSTI)

    Hamstra, Daniel A., E-mail: dhamm@umich.edu [University of Michigan, Ann Arbor, Michigan (United States); Bae, Kyounghwa [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Pilepich, Miljenko V. [UCLA Medical Center, Los Angeles, California (United States); Hanks, Gerald E. [Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Grignon, David J. [Indiana University-Purdue University Indianapolis, Indiana (United States); McGowan, David G. [Cross Cancer Institute, Edmonton, Alberta (Canada); Roach, Mack [UCSF, San Francisco, California (United States); Lawton, Colleen [Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Lee, R. Jeffrey [Intermountain Medical Center, Salt Lake City, Utah (United States); Sandler, Howard [Cedars-Sinai Medical Center, Los Angeles, California (United States)

    2011-12-01T23:59:59.000Z

    Purpose: The impact of age on prostate cancer (PCa) outcome has been controversial; therefore, we analyzed the effect of age on overall survival (OS), distant metastasis, prostate cancer-specific death (PCSD), and nonprostate cancer death (NPCD) on patients with locally advanced PCa. Methods and Materials: Patients who participated in four Radiation Therapy Oncology Group (RTOG) phase III trials, 8531, 8610, 9202, and 9413, were studied. Cox proportional hazards regression was used for OS analysis, and cumulative events analysis with Fine and Gray's regression was used for analyses of metastasis, PCSD, and NPCD. Results: Median follow-up of 4,128 patients with median age of 70 (range, 43-88 years) was 7.3 years. Most patients had high-risk disease: cT3 to cT4 (54%) and Gleason scores (GS) of 7 (45%) and 8 to 10 (27%). Older age ({<=}70 vs. >70 years) predicted for decreased OS (10-year rate, 55% vs. 41%, respectively; p < 0.0001) and increased NPCD (10-year rate, 28% vs. 46%, respectively; p < 0.0001) but decreased metastasis (10-year rate, 27% vs. 20%, respectively; p < 0.0001) and PCSD (10-year rate, 18% vs. 14%, respectively; p < 0.0001). To account for competing risks, outcomes were analyzed in 2-year intervals, and age-dependent differences in metastasis and PCSD persisted, even in the earliest time periods. When adjusted for other covariates, an age of >70 years remained associated with decreased OS (hazard ratio [HR], 1.56 [95% confidence interval [CI], 1.43-1.70] p < 0.0001) but with decreased metastasis (HR, 0.72 [95% CI, 0.63-0.83] p < 0.0001) and PCSD (HR, 0.78 [95% CI, 0.66-0.92] p < 0.0001). Finally, the impact of the duration of androgen deprivation therapy as a function of age was evaluated. Conclusions: These data support less aggressive PCa in older men, independent of other clinical features. While the biological underpinning of this finding remains unknown, stratification by age in future trials appears to be warranted.

  1. Reform of the EIA process in Indonesia: improving the role of public involvement

    SciTech Connect (OSTI)

    Purnama, Dadang

    2003-07-01T23:59:59.000Z

    The implementation of Environmental Impact Assessment (EIA) as a planning tool has been utilised for a relatively long time in Indonesia. It was introduced formally through the Act No. 4/1982. Supporting regulation was established in 1986 when Government Regulation No. 29 was enacted. After developing the EIA system for 14 years, Indonesia finally recognized the importance of emphasizing public involvement in the EIA guidelines of 2000. EIA in the previous Indonesian regulations, i.e. Regulation No. 29/1986 and No. 51/1993, did not have provisions for direct public involvement. The Indonesian Government Regulation No. 27/1999 is currently accommodating the above issue. Guidelines for public announcement and public involvement have been introduced in a decree issued by the Head of Indonesia's Environmental Impact Management Agency No. KepDal 08/2000. This was officially enacted on 7 November 2000 in response to the demand for more public involvement, an issue that was ambiguous in the previous legislation. This paper discusses: the implementation of the new guidelines; what has been achieved; and the challenges during implementation. While the paper focuses its review on the Indonesian EIA system, Indonesia's experience is relevant to many other developing countries that are starting to adopt public involvement in their decision-making processes.

  2. The Community Environmental Monitoring Program: Reducing Public Perception of Risk through Stakeholder Involvement

    SciTech Connect (OSTI)

    William T. Hartwell

    2007-05-21T23:59:59.000Z

    The Community Environmental Monitoring Program (CEMP) has promoted stakeholder involvement, awareness, and understanding of radiological surveillance in communities surrounding the Nevada Test Site (NTS) since 1981. It involves stakeholders in the operation, data collection, and dissemination of information obtained from a network of 29 stations across a wide area of Nevada, Utah and California. It is sponsored by the U.S. Department of Energy, National Nuclear Security Administration’s Nevada Site Office (NNSA/NSO) and administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. Integration of a near real-time communications system, a public web site, training workshops for involved stakeholders, and educational programs all help to alleviate public perception of risk of health effects from past activities conducted at the NTS.

  3. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect (OSTI)

    United States. Bonneville Power Administration.

    1994-01-01T23:59:59.000Z

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  4. Staying Competitive in the 90's: How to Make Public Involvement Work for Your Energy Project

    E-Print Network [OSTI]

    Loveless, K. W.

    STAYING COMPETITIVE IN THE 90'S: HOW TO MAKE PUBLIC INVOL VEMENT WORK FOR YOUR ENERGY PROJECT Kat11Y Wood LOVl;!cSS, Prcsidl;l1t, Loveless EnLerprises, Inc., Salt Lake City, Utah ABSTRACT Gone are the days when energy companies could develop... in Washington, D. c., and Denver. She has been analyzing, planning, conducting public involvement events for more than 2 decades. For a free copy of more public involvement techniques call 801-363-1807 or write: 267 E. North Sandrun Rd.,Salt Lake City, Utah...

  5. Study Finds that Children with Autism and Gastrointestinal Symptoms Have Altered Expression of Genes Involved in Digestion

    E-Print Network [OSTI]

    Salzman, Daniel

    of Genes Involved in Digestion These changes may also affect the mix of bacteria present in the digestive disturbances have altered expression of genes involved in digestion. These variations may contribute to changes

  6. A study to examine community involvement in major U.S.military base closures and realignments from 1988 to 2001

    E-Print Network [OSTI]

    Yahn, Nancy Stiles

    2005-11-01T23:59:59.000Z

    This study examines community involvement in major U.S. military base closures and realignments from 1988 to 2001. There were four waves of base closures during this time. They were in 1988, 1991, 1993, and 1995. Community involvement became...

  7. RASRAFMEK-dependent oxidative cell death involving voltage-dependent anion channels

    E-Print Network [OSTI]

    Stockwell, Brent R.

    LETTERS RAS­RAF­MEK-dependent oxidative cell death involving voltage-dependent anion channels J. Fridman1 , Adam J. Wolpaw1 , Inese Smukste1 , John M. Peltier3 , J. Jay Boniface3 , Richard Smith that discriminate between the genetic makeup of normal cells and tumour cells are valuable for treating and under

  8. Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons

    E-Print Network [OSTI]

    Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons for wing morphometry, 12 for cuticular hydrocarbons and five for venom components. We detected 50 QTL / cuticular hydrocarbons / venom 1. INTRODUCTION The first genetic map built from RAPD markers (Hunt and Page

  9. Adaptive Density Estimation in the Pile-up Model Involving Measurement Errors

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Adaptive Density Estimation in the Pile-up Model Involving Measurement Errors Fabienne Comte, Tabea of nonparametric density estimation in the pile-up model. Adaptive nonparametric estimators are proposed for the pile-up model in its simple form as well as in the case of additional measurement errors. Furthermore

  10. A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis

    E-Print Network [OSTI]

    Thomas, David D.

    ) carboxylases involved in fatty acid metabolism and pyruvate carboxylase in gluco- neogenesis [5]. Biotin] and alanine to afford (8S)-8-amino-7-oxononanoic acid 2, whose more common trivial name is 7-keto-8-aminopelargonic acid (KAPA) (Fig. 1) [9,10]. In the second step, KAPA 2 is transaminated to (7R,8S)-7

  11. CLOUD CHAMBER: A PERFORMANCE INVOLVING REAL TIME TWO-WAY INTERACTION BETWEEN SUBATOMIC RADIOACTIVE

    E-Print Network [OSTI]

    Miranda, Eduardo Reck

    " by the radiation-generated ion patterns in the glass chamber. If John plays in one way the ion particlesCLOUD CHAMBER: A PERFORMANCE INVOLVING REAL TIME TWO-WAY INTERACTION BETWEEN SUBATOMIC RADIOACTIVE, Harwell, Oxford, UK ABSTRACT ,,Cloud Chamber is a live performance created by composer Alexis Kirke

  12. Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene Receptor

    E-Print Network [OSTI]

    Klee, Harry J.

    Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene ethylene's role in plant response to virulent and avirulent strains of Xanthomonas campestris pv overexpressing a wild-type NR cDNA were infected with virulent X. campestris pv. vesicatoria. Like the Nr mutant

  13. Guidance for Preparing Research Proposals Involving Diagnostic Use of Ionizing Radiation in Human Use Research

    E-Print Network [OSTI]

    Kay, Mark A.

    Guidance for Preparing Research Proposals Involving Diagnostic Use of Ionizing Radiation in Human Use Research Introduction This guidance has been prepared by the Clinical Radiation Safety Committee of ionizing radiation. CRSCo serves under California Department of Health Services regulations and Nuclear

  14. On the Cover: One route to harvesting the energy of the sun involves learning to mimic

    E-Print Network [OSTI]

    Wu, Zhigang

    #12;On the Cover: One route to harvesting the energy of the sun involves learning to mimic natural the chlorophylls, which play a central role in capturing light and using its energy for photosynthesis in green, and atmospheric carbon dioxide. #12;BASIC RESEARCH NEEDS FOR SOLAR ENERGY UTILIZATION Report on the Basic Energy

  15. DEA Efficiency Analysis Involving Multiple Production Processes with an Application to

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    with which input resources are allocated to the subunits. It introduces a simple model for efficientlyDEA Efficiency Analysis Involving Multiple Production Processes with an Application to Urban Mass in the Department of Information Systems and Technology within in the College of Business Administration

  16. Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by FeO

    E-Print Network [OSTI]

    Metz, Ricardo B.

    Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by Fe.1063/1.1448489 I. INTRODUCTION The direct oxidation of methane to an easily transport- able liquid such as methanol process and as the simplest model for alkane oxidation.1,2 Although no direct, efficient methane­methanol

  17. Distributional properties of Euclidean distances in wireless networks involving road systems

    E-Print Network [OSTI]

    Schmidt, Volker

    1 Distributional properties of Euclidean distances in wireless networks involving road systems of large wireless networks. The network geometry is modelled by random geometric graphs, and the locations are closely related with the interference geometry and, consequently, the performance of wireless networks

  18. Ohio State Colleges/Units Involved College of Arts and Sciences

    E-Print Network [OSTI]

    Nahar, Sultana Nurun

    Affairs Community Partners Involved Indian Universities: Aligarh Muslim University Delhi University Saudi Arabian universities Obama-Singh 21st Century Knowledge Initiative Award Project: STEM Education members. For the project, the OSU partnership with Aligarh Muslim University (AMU) in India received one

  19. Director, MIT Libraries A great benefit of involvement in the planning for MIT's 150th

    E-Print Network [OSTI]

    Reuter, Martin

    Director, MIT Libraries A great benefit of involvement in the planning for MIT's 150th anniversary, and then sustain, MIT's novel and visionary educational philosophy of "Mens et Manus." MIT's future- oriented a university library system that is, like MIT itself, inventive and forward looking. From an early expectation

  20. DNA Identification of Mountain Lions Involved in Livestock Predation and Public Safety Incidents and Investigations

    E-Print Network [OSTI]

    Ernest, Holly

    1 DNA Identification of Mountain Lions Involved in Livestock Predation and Public Safety Incidents concolor, bobcat, forensic, genetics, DNA techniques, noninvasive sampling, fecal DNA, prey swab DNA ABSTRACT Using three case studies, we demonstrated the utility of techniques to analyze DNA from trace

  1. Involvement of the Czech environmental movements in the European game: which impact on their repertory of

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    73 Involvement of the Czech environmental movements in the European game: which impact observe that each country is embedded in its own history. Communism for example, has been experienced. In my own case, these issues have been analysed using Czech environmental actors. #12;Social Movement

  2. PROJECT GOALS This project involved the development of the first Carbon

    E-Print Network [OSTI]

    emissions, which will in turn allow prioritisation of actions to reduce the ANU carbon footprint. TYPEPROJECT GOALS This project involved the development of the first Carbon Emissions Inventory report and master Excel spreadsheet Figure 1: ANU Carbon Emission by Category (t CO2e) DESCRIPTION

  3. MINIMIZERS OF COST-FUNCTIONS INVOLVING NONSMOOTH DATA-FIDELITY TERMS. APPLICATION TO THE

    E-Print Network [OSTI]

    Nikolova, Mila

    MINIMIZERS OF COST-FUNCTIONS INVOLVING NONSMOOTH DATA-FIDELITY TERMS. APPLICATION TO THE PROCESSING cost- function F(x, y) = (x, y) + (x), where is a data-fidelity term, is a smooth regularization term construct a cost-function allowing aberrant data (outliers) to be detected and to be selectively smoothed

  4. PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

    E-Print Network [OSTI]

    Peng, Qianqian; Zhao, Jinghua; Xue, Fuzhong

    2010-01-26T23:59:59.000Z

    2005, 77:567-581. 23. Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, Helm-van Mil van der AHM, Toes REM, Huizinga TW, Klareskog L, Alfredsson L, et al: Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking...

  5. RISK ASSESSMENT OF A FIRE INVOLVING COMBUSTIBLE MATERIALS IN A WAREHOUSE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    in "4. International seminar on fire and explosion hazards, Londonderry : Ireland (2003)" #12;SeRISK ASSESSMENT OF A FIRE INVOLVING COMBUSTIBLE MATERIALS IN A WAREHOUSE Wang, H.Y. ', Russo, P modeling into a rack fire in warehouse, and an identifi- cation of the visible flame shape when a fire

  6. Cytosolic High Km 5 -Nucleotidase and 5 (3 )-Deoxyribonucleotidase in Substrate Cycles Involved in Nucleotide Metabolism*

    E-Print Network [OSTI]

    Bianchi, Vera

    in Nucleotide Metabolism* Received for publication, August 21, 2000, and in revised form, November 14, 2000 that the hkm-NT is not involved in the regulation of deoxyribo- nucleotide pools but affects IMP and GTP pools. dNT-1, instead, appears to be the catabolic arm of substrate cycles regulating pyrimidine nucleotide

  7. Statistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter

    E-Print Network [OSTI]

    Washington at Seattle, University of

    of the Workshop was to initiate a statistical research program relevant to setting air quality standardsStatistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter Lawrence H. Cox NRCSET e c h n i c a l R e p o r t S e r i e s NRCSE-TRS No. 041 January 10, 2000 The NRCSEwas

  8. Emergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    -492-6025. For Non-Emergency Fire and Natural Gas Questions call the CU Fire Marshall @ 303-492-4042. AdditionalEmergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas leaks, the following actions should be taken: 1) Life Safety First 2) Evacuate Immediate Area 3

  9. Differing Professional Opinions Manual for Technical Issues Involving Environment, Safety, and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-11-16T23:59:59.000Z

    This Manual establishes a differing professional opinion (DPO) policy to a Department of Energy (DOE) Differing Professional Opinion (DPO) Process to encourage and facilitate dialogue and resolution on DPOs from employees for technical issues involving environment, safety, and health. Does not cancel other directives. Canceled by DOE O 442.2.

  10. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01T23:59:59.000Z

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  11. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01T23:59:59.000Z

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county`s future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  12. Utility/Industry Partnerships Involving Distributed Generation Technologies in Evolving Electricity Markets

    E-Print Network [OSTI]

    Rastler, D. M.

    Wires Manage Wires defer capital Optimize Energy Services Not Utility Business Not Utility Business New Business Opportunities DISTRIBUTED GENERATION Distributed generation includes small gas turbines, micro-turbines, fuel cells, storage...UTILITYIINDUSTRY PARTNERSHIPS INVOLVING DISTRIBUTED GENERATION TECHNOLOGIES IN EVOLVING ELECTRICITY MARKETS Daniel M. Rastler Manager, Fuel Cells and Distributed Generation Electric Power Research Institute Palo Alto, California ABSTRACT...

  13. Weather encapsulates the state of the atmosphere, primarily involving the component which affects

    E-Print Network [OSTI]

    Allan, Richard P.

    1 #12;2 Weather encapsulates the state of the atmosphere, primarily involving the component which and Telegraph readers tend to use oF #12;5 The human body has an energy balance just like the Earth (solar range in larger on still, clear days, when solar heating is strong at the surface and is not offset

  14. Eight interesting identities involving the exponential function, derivatives, and Stirling numbers of the second kind

    E-Print Network [OSTI]

    Qi, Feng

    2012-01-01T23:59:59.000Z

    In the paper, the author establishes some identities which show that the functions $\\frac1{(1-e^{\\pm t})^k}$ and the derivatives $\\bigl(\\frac1{e^{\\pm t}-1}\\bigr)^{(i)}$ can be expressed each other by linear combinations with coefficients involving the combinatorial numbers and the Stirling numbers of the second kind, where $t\

  15. Thermal Sciences The thermal sciences area involves the study of energy conversion and transmission, power

    E-Print Network [OSTI]

    New Hampshire, University of

    Thermal Sciences The thermal sciences area involves the study of energy conversion and transmission, power generation, the flow of liquids and gases, and the transfer of thermal energy (heat) by means in virtually all energy conversion devices and systems. One may think of the jet engine as a mechanical device

  16. Second-order integrals of motion for spin involving systems in $E_2$

    E-Print Network [OSTI]

    Ismet Yurdusen

    2014-07-16T23:59:59.000Z

    In two-dimensional Euclidean plane, existence of second-order integrals of motion is investigated for integrable Hamiltonian systems involving spin (\\emph{e.g.,} those systems describing interaction between two particles with spin 0 and spin 1/2) and it has been shown that no nontrivial second-order integrals of motion exist for such systems.

  17. Predicting Pelvic Lymph Node Involvement in Current-Era Prostate Cancer

    SciTech Connect (OSTI)

    Rahman, Sophia, E-mail: sophs1578@yahoo.com [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States); Cosmatos, Harry [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States); Dave, Giatri [Kaiser Permanente Medical Center, Department of Radiation Oncology, Fresno, CA (United States); Williams, Stephen [Kaiser Permanente Medical Center, Department of Urology, Los Angeles, CA (United States); Tome, Michael [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States)

    2012-02-01T23:59:59.000Z

    Purpose: The Roach formula [2/3 Multiplication-Sign prostate-specific antigen + (Gleason score - 6) Multiplication-Sign 10], derived in 1993 during the early prostate specific antigen (PSA) screening era, has been used to predict the risk of pelvic lymph node involvement in patients with prostate cancer. In the current era of widespread PSA screening with a shift to earlier disease stages, there is evidence to suggest that the Roach score overestimates risk of nodal metastasis. This study retrospectively reviews the validity of this formula as a prediction tool. Methods and Materials: We conducted a retrospective institutional review including men with clinical T1c-T3 prostate cancer, with baseline PSA levels and biopsy-obtained Gleason scores who underwent radical prostatectomy with pelvic node dissection from 2001 through 2009 (N = 1,022). The predicted risk of nodal involvement was calculated for each patient using the Roach formula and then compared with actual rates following surgery. Results: The study included 1,022 patients; 99.6% had clinical T1c/T2 disease, with a mean of 10.3 lymph nodes surgically evaluated. Overall, 42 patients (4.1%) had nodal metastasis. For every range of scores, the Roach formula overestimates the risk of nodal involvement. Observed nodal positivity was 1%, 6.3%, 10%, 15.2%, and 16.7% for Roach scores {<=}10%, >10%-20%, >20%-30%, >30%-40%, and >40%, respectively. The Roach score overestimates the risk by approximately 4.5-fold in patients with scores {<=}10%, by 2.5-fold for all scores between 10% and 40%, and by 4-fold for scores >40%. Conclusion: The Roach formula overpredicts the risk of pelvic nodal involvement in current-era prostate cancer patients undergoing regular PSA screening and with mainly T1c/T2 disease. Contemporary patients are much less likely to have nodal involvement for a given PSA and Gleason score.

  18. Housing Checklist for Older Adults.

    E-Print Network [OSTI]

    Anonymous,

    1980-01-01T23:59:59.000Z

    : Yes D No D 3 Yes No LOCATION AND ORIENTATION D D The home is located in a neighborhood close to friends. D D Ages of others in the neighborhood are acceptable. D D Transportation, shopping, churches, parks and com- munity centers are convenient.... D D Area is free from heavy traffic, dangerous street cros- sings, excessive noise and obnoxious odors. D D Amount of lawn and landscape to be maintained is reasonable. D D Land is reasonably level to avoid the need for steps, steep walks...

  19. Public involvement in integrated resource planning: A study of demand-side management collaboratives

    SciTech Connect (OSTI)

    Raab, J. (Raab (J.), Boston, MA (United States)); Schweitzer, M. (Oak Ridge National Lab., TN (United States))

    1992-02-01T23:59:59.000Z

    Many utilities and nonutility parties (NUPs) across the country have tried a new approach to reaching agreement on Demand-Side Management (DSM) program design and policy issues. Through this, which is called the DSM collaborative process, parties who have often been adversaries in the past attempt to reach consensus rather than using traditional litigation to resolve differences. We examined nine cases of DSM collaboration involving 24 utilities and approximately 50 NUPs in 10 states. This is the first comprehensive, in-depth review and assessment of collaboratives and it allows conclusions to be drawn about the collaborative process and the factors that contribute to successful efforts of this type. Collaboratives are described in terms of four major contextual and organizational characteristics: regulatory and legal history, parties involved and parties excluded, collaborative scope, and the collaborative process itself.

  20. Spatial arrangement of trail markers and visitor involvement on a self-guided interpretive trail 

    E-Print Network [OSTI]

    Marcy, Julie Benedict

    1982-01-01T23:59:59.000Z

    be presented by asking "what constitutes an effective SGT in terms of visitor involvement with t'ne trail, leaflet suggestions, and the spacing of stakes or markers on the trail?" An effecrive program or technique is one which achieves its desired... concluded with open-ended questions on suggested improvements for the trail and leaflet. Sontag (27) states rhat there are three main ccmponents of t. rail evaluation: personal objeccive evaluation, observing visitor reaction, and questionnaires...

  1. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF

    SciTech Connect (OSTI)

    Li, Feifei; Jiang, Yinan [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China); Zheng, Qiping [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States)] [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States); Yang, Xiaoming [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China)] [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China); Wang, Siying, E-mail: sywang@ahmu.edu.cn [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)

    2011-01-07T23:59:59.000Z

    Research highlights: {yields} TEC is rapidly tyrosine-phosphorylated and activated by HGF-stimulation in vivo or after partial hepatectomy in mice. {yields} TEC enhances the activity of Elk and serum response element (SRE) in HGF signaling pathway in hepatocyte. {yields} TEC promotes hepatocyte proliferation through the Erk-MAPK pathway. -- Abstract: Background/aims: TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore which signaling pathway TEC is involved in, and how TEC is activated in hepatocyte after hepatectomy and hepatocyte growth factor (HGF) stimulation. Methods: We performed immunoprecipitation (IP) and immunoblotting (IB) to examine TEC tyrosine phosphorylation after partial hepatectomy in mice and HGF stimulation in WB F-344 hepatic cells. The TEC kinase activity was determined by in vitro kinase assay. Reporter gene assay, antisense oligonucleotide and TEC dominant negative mutant (TEC{sup KM}) were used to examine the possible signaling pathways in which TEC is involved. The cell proliferation rate was evaluated by {sup 3}H-TdR incorporation. Results: TEC phosphorylation and kinase activity were increased in 1 h after hepatectomy or HGF treatment. TEC enhanced the activity of Elk and serum response element (SRE). Inhibition of MEK1 suppressed TEC phosphorylation. Blocking TEC activity dramatically decreased the activation of Erk. Reduced TEC kinase activity also suppressed the proliferation of WB F-344 cells. These results suggest TEC is involved in the Ras-MAPK pathway and acts between MEK1 and Erk. Conclusions: TEC promotes hepatocyte proliferation and regeneration and is involved in HGF-induced Erk signaling pathway.

  2. Temperature of aircraft cargo flame exposure during accidents involving fuel spills

    SciTech Connect (OSTI)

    Mansfield, J.A.

    1993-01-01T23:59:59.000Z

    This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

  3. Effects of Parent Expectations and Involvement on the School Readiness of Children in Head Start

    E-Print Network [OSTI]

    Cook, Krystal Tisha'

    2010-10-12T23:59:59.000Z

    EFFECTS OF PARENT EXPECTATIONS AND INVOLVEMENT ON THE SCHOOL READINESS OF CHILDREN IN HEAD START A Dissertation by KRYSTAL TISHA? COOK Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of children enrolled in Head Start. The study examined how these iv parent variables were related to children?s school readiness, and differences between ethnic groups, gender groups, and level of risk. The study tested a model whereby the effect...

  4. Involvement of HIF-2?-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Zhao, Yue; Xu, Wenchao; Luo, Fei; Wang, Bairu; Li, Yuan; Pang, Ying; Liu, Qizhan, E-mail: drqzliu@hotmail.com

    2013-10-15T23:59:59.000Z

    Arsenic is a well established human carcinogen that causes diseases of the lung. Some studies have suggested a link between inflammation and lung cancer; however, it is unknown if arsenite-induced inflammation causally contributes to arsenite-caused malignant transformation of cells. In this study, we investigated the molecular mechanisms underlying inflammation during neoplastic transformation induced in human bronchial epithelial (HBE) cells by chronic exposure to arsenite. The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1? (IL-1?). The data also indicated that HIF-2? was involved in arsenite-induced inflammation. Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells. Thus, these experiments show that HIF-2? mediates arsenite-induced inflammation and that such inflammation is involved in arsenite-induced malignant transformation of HBE cells. The results provide a link between the inflammatory response and the acquisition of a malignant transformed phenotype by cells chronically exposed to arsenite and thus establish a previously unknown mechanism for arsenite-induced carcinogenesis. - Highlights: • Arsenite induces inflammation. • Arsenite-induced the increases of IL-6 and IL-8 via HIF-2?. • Inflammation is involved in arsenite-induced carcinogenesis.

  5. A review of two recent occurrences at the Advanced Test Reactor involving subcontractor activities

    SciTech Connect (OSTI)

    Dahlke, H.J.; Jensen, N.C.; Vail, J.A.

    1997-11-01T23:59:59.000Z

    This report documents the results of a brief, unofficial investigation into two incidents at the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Test Reactor (ATR) facility, reported on October 25 and 31, 1997. The first event was an unanticipated breach of confinement. The second involved reactor operation with an inoperable seismic scram subsystem, violating the reactor`s Technical Specifications. These two incidents have been found to be unrelated. A third event that occurred on December 16, 1996, is also discussed because of its similarities to the first event listed above. Both of these incidents were unanticipated breaches of confinement, and both involved the work of construction subcontractor personnel. The cause for the subcontractor related occurrences is a work control process that fails to effectively interface with LMITCO management. ATR Construction Project managers work sufficient close with construction subcontractor personnel to understand planned day-to-day activities. They also have sufficient training and understanding of reactor operations to ensure adherence to applicable administrative requirements. However, they may not be sufficiently involved in the work authorization and control process to bridge an apparent communications gap between subcontractor employees and Facility Operations/functional support personnel for work inside the reactor facility. The cause for the inoperable seismic scram switch (resulting from a disconnected lead) is still under investigation. It does not appear to be subcontractor related.

  6. The Function and Genetic Interactions of Zebrafish atoh1 and sox2: Genes Involved in Hair Cell Development and Regeneration

    E-Print Network [OSTI]

    Millimaki, Bonny Butler

    2010-10-12T23:59:59.000Z

    THE FUNCTION AND GENETIC INTERACTIONS OF ZEBRAFISH atoh1 AND sox2: GENES INVOLVED IN HAIR CEL DEVELOPMENT AND REGENERATION A Disertation by BONY BUTLER MILIMAKI Submited to the Ofice of Graduate Studies of Texas A... Involved in Hair Cel Development and Regeneration. Copyright 2010 Bonny Butler Milimaki THE FUNCTION AND GENETIC INTERACTIONS OF ZEBRAFISH atoh1 AND sox2: GENES INVOLVED IN HAIR CEL DEVELOPMENT AND REGENERATION A Disertation by BONY...

  7. THE RELATIONSHIP BETWEEN HIGH INVOLVEMENT WORK SYSTEMS, SUPERVISORY SUPPORT, AND ORGANIZATIONAL EFFECTIVENESS: THE ROLE OF EMPLOYEE EXPERIENCES AT WORK

    E-Print Network [OSTI]

    Wadhwa, Preeti

    2012-08-31T23:59:59.000Z

    This study adopts a multilevel, multiple stakeholder perspective to examine the impact of high involvement work systems (HIWS) and supervisory support on organizational effectiveness. Organizational effectiveness is measured ...

  8. Involvement of purinergic system in inflammation and toxicity induced by copper in zebrafish larvae

    SciTech Connect (OSTI)

    Leite, Carlos Eduardo, E-mail: carlos.leite@pucrs.br [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, CEP 90035-003 (Brazil); Maboni, Lucas de Oliveira [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Cruz, Fernanda Fernandes [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Farmácia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Rosemberg, Denis Broock [Programa de Pós-graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, CEP 89809-000 (Brazil); and others

    2013-11-01T23:59:59.000Z

    The use of zebrafish (Danio rerio) is increasing as an intermediate preclinical model, to prioritize drug candidates for mammalian testing. As the immune system of the zebrafish is quite similar to that of mammals, models of inflammation are being developed for the screening of new drugs. The characterization of these models is crucial for studies that seek for mechanisms of action and specific pharmacological targets. It is well known that copper is a metal that induces damage and cell migration to hair cells of lateral line of zebrafish. Extracellular nucleotides/nucleosides, as ATP and adenosine (ADO), act as endogenous signaling molecules during tissue damage by exerting effects on inflammatory and immune responses. The present study aimed to characterize the inflammatory status, and to investigate the involvement of the purinergic system in copper-induced inflammation in zebrafish larvae. Fishes of 7 days post-fertilization were exposed to 10 ?M of copper for a period of 24 h. The grade of oxidative stress, inflammatory status, copper uptake, the activity and the gene expression of the enzymes responsible for controlling the levels of nucleotides and adenosine were evaluated. Due to the copper accumulation in zebrafish larvae tissues, the damage and oxidative stress were exacerbated over time, resulting in an inflammatory process involving IL-1?, TNF-?, COX-2 and PGE{sub 2}. Within the purinergic system, the mechanisms that control the ADO levels were the most involved, mainly the reactions performed by the isoenzyme ADA 2. In conclusion, our data shed new lights on the mechanisms related to copper-induced inflammation in zebrafish larvae. - Graphical abstract: This scheme provides a chronological proposition for the biochemical events induced by copper in zebrafish larvae. The dashed line shows the absorption of copper over the exposure time. After 1 h of exposure to copper, the release of PGE{sub 2} occurs, followed by an increase of MPO (as a consequence of neutrophil migration), increased expression of genes involved in inflammatory events (IL-1? and TNF-?) and, reduction of the anti-inflammatory cytokine IL-10 at 4 h. At 24 h, the copper concentration is found highly increased, what is coincident with oxidative stress. Regarding the purinergic system, it is possible to observe an inhibition of ecto-5?-NT and ADA, with the consequent increase of AMP and ADA, respectively, at 24 h. The expression of enzyme-related genes shows a decrease in the expression of ecto-5?-NT and variable expressions of ADA subfamily enzymes. - Highlights: • Copper led to increased oxidative stress, and decreased the antioxidants' defenses. • Copper induced time-related changes of IL-1?, TNF-?, IL-10 and PGE{sub 2} levels. • ADA activity controls the levels of adenosine in copper-induced inflammation. • ADA 2 is the main ADA subfamily involved. • The purinergic system seems to be involved in the resolution of inflammation.

  9. Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation. Final report

    SciTech Connect (OSTI)

    Baulch, Janet

    2013-09-11T23:59:59.000Z

    This is a 'glue grant' that was part of a DOE Low Dose project entitled 'Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation'. This collaborative program has involved Drs. David L. Springer from Pacific Northwest National Laboratory (PNNL), John H. Miller from Washington State University, Tri-cities (WSU) and William F. Morgan then from the University of Maryland, Baltimore (UMB). In July 2008, Dr. Morgan moved to PNNL and Dr. Janet E. Baulch became PI for this project at University of Maryland. In November of 2008, a one year extension with no new funds was requested to complete the proteomic analyses. The project stemmed from studies in the Morgan laboratory demonstrating that genomically unstable cells secret a soluble factor or factors into the culture medium, that cause cytogenetic aberrations and apoptosis in normal parental GM10115 cells. The purpose of this project was to identify the death inducing effect (DIE) factor or factors, estimate their relative abundance, identify the cell signaling pathways involved and finally recapitulate DIE in normal cells by exogenous manipulation of putative DIE factors in culture medium. As reported in detail in the previous progress report, analysis of culture medium from the parental cell line, and stable and unstable clones demonstrated inconsistent proteomic profiles as relate to candidate DIE factors. While the proposed proteomic analyses did not provide information that would allow DIE factors to be identified, the analyses provided another important set of observations. Proteomic analysis suggested that proteins associated with the cellular response to oxidative stress and mitochondrial function were elevated in the medium from unstable clones in a manner consistent with mitochondrial dysfunction. These findings correlate with previous studies of these clones that demonstrated functional differences between the mitochondria of stable and unstable clones. These mitochondrial abnormalities in the unstable clones contributes to oxidative stress.

  10. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain

    SciTech Connect (OSTI)

    Lin, Anya M.Y. [Department of Physiology, National Yang-Ming University, Taipei, Taiwan (China); Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chao, P.L.; Fang, S.F.; Chi, C.W. [Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Yang, C.H. [Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan (China)], E-mail: chihyang@ntu.edu.tw

    2007-10-15T23:59:59.000Z

    The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN. Aggregation of {alpha}-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN. From the breakdown pattern of {alpha}-spectrin, both necrosis and apoptosis were involved in the arsenite-induced neurotoxicity. Pyknotic nuclei, cellular shrinkage and cytoplasmic disintegration, indicating necrosis, and TUNEL-positive cells and DNA ladder, indicating apoptosis was observed in the arsenite-infused SN. Arsenite-induced apoptosis was mediated via two different organelle pathways, mitochondria and endoplasmic reticulum (ER). For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels. Moreover, arsenite reduced procaspase 12 levels, an ER-specific enzyme in the infused SN. Taken together, our study suggests that arsenite is capable of inducing oxidative injury in CNS. In addition to mitochondria, ER stress was involved in the arsenite-induced apoptosis. Arsenite-induced neurotoxicity clinically implies a pathophysiological role of arsenite in CNS neurodegeneration.

  11. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    Not Available

    1999-01-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  12. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    NONE

    1999-11-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  13. The Conducting of a Mining Negotiation Showing the Scheme of Engineering Involved

    E-Print Network [OSTI]

    Hansen, George T.

    1911-01-01T23:59:59.000Z

    and capable of lifting the heaviest piece of any one of these machines. CEAIIT BLOCKS:- One fl) 8 ton triplex chain block, complete, equip- ped with sufficient chain for a 14* lift. One (1) 3 ton triplex chain block, equipped with sufficient chain for a 22... E S I S , "The conducting of a Mining negotiation Show- ng the Scheme of Engineering Involved." Taken from Actual Practice 13 7 SEQRGE T. HAISB1 MIIIIS SALES EET5IHEBR ALLIS GHALMBBS OOMPASY ST. LOUIS, MISSOURI Presented to the College...

  14. Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide

    SciTech Connect (OSTI)

    Kurokawa, Yuko; Sekiguchi, Fumiko; Kubo, Satoko; Yamasaki, Yoshiko; Matsuda, Sachi; Okamoto, Yukari; Sekimoto, Teruki; Fukatsu, Anna; Nishikawa, Hiroyuki [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Kume, Toshiaki [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Fukushima, Nobuyuki [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Akaike, Akinori [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Kawabata, Atsufumi, E-mail: kawabata@phar.kindai.ac.jp [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)

    2011-11-04T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Hydrogen sulfide causes NMDA receptor-independent neurotoxicity in mouse fetal cortical neurons. Black-Right-Pointing-Pointer Activation of ERK mediates the toxicity of hydrogen sulfide. Black-Right-Pointing-Pointer Apoptotic mechanisms are involved in the hydrogen-induced cell death. -- Abstract: Hydrogen sulfide (H{sub 2}S), a gasotransmitter, exerts both neurotoxicity and neuroprotection, and targets multiple molecules including NMDA receptors, T-type calcium channels and NO synthase (NOS) that might affect neuronal viability. Here, we determined and characterized effects of NaHS, an H{sub 2}S donor, on cell viability in the primary cultures of mouse fetal cortical neurons. NaHS caused neuronal death, as assessed by LDH release and trypan blue staining, but did not significantly reduce the glutamate toxicity. The neurotoxicity of NaHS was resistant to inhibitors of NMDA receptors, T-type calcium channels and NOS, and was blocked by inhibitors of MEK, but not JNK, p38 MAP kinase, PKC and Src. NaHS caused prompt phosphorylation of ERK and upregulation of Bad, followed by translocation of Bax to mitochondria and release of mitochondrial cytochrome c, leading to the nuclear condensation/fragmentation. These effects of NaHS were suppressed by the MEK inhibitor. Our data suggest that the NMDA receptor-independent neurotoxicity of H{sub 2}S involves activation of the MEK/ERK pathway and some apoptotic mechanisms.

  15. Innocuous oil as an additive for reductive reactions involving zero valence iron

    SciTech Connect (OSTI)

    Cary, J.W.; Cantrell, K.J.

    1994-11-01T23:59:59.000Z

    Reductive reactions involving zero valence iron appear to hold promise for in situ remediation of sites containing chlorinated hydrocarbon solvents and certain reducible metals and radionuclides. Treatment involves the injection of metallic iron and the creation of low levels of dissolved oxygen in the aqueous phase through oxidation of the metallic iron. The use of a biodegradable immiscible and innocuous organic liquid such as vegetable oil as an additive offers several intriguing possibilities. The oil phase creates a large oil-water interface that is immobile with respect to flow in the aqueous phase. This phase will act as a trap for chlorinated hydrocarbons and could potentially increase the reaction efficiency of reductive dehalogenation of chlorinated hydrocarbons by the metallic iron. When iron particles are suspended in the oil before injection they are preferentially held in the oil phase and tend to accumulate at the oil-water interface. Thus oil injection can serve as a mechanism for creating a stable porous curtain of metallic iron in the vadose to maintain a low oxygen environment which will minimize the consumption of the iron by molecular oxygen.

  16. Mechanochemical modeling of dynamic microtubule growth involving sheet-to-tube transition

    E-Print Network [OSTI]

    Xiang-Ying Ji; Xi-Qiao Feng

    2011-08-02T23:59:59.000Z

    Microtubule dynamics is largely influenced by nucleotide hydrolysis and the resultant tubulin configuration changes. The GTP cap model has been proposed to interpret the stabilizing mechanism of microtubule growth from the view of hydrolysis effects. Besides, the microtubule growth involves the closure of a curved sheet at its growing end. The curvature conversion also helps to stabilize the successive growth, and the curved sheet is referred to as the conformational cap. However, there still lacks theoretical investigation on the mechanical-chemical coupling growth process of microtubules. In this paper, we study the growth mechanisms of microtubules by using a coarse-grained molecular method. Firstly, the closure process involving a sheet-to-tube transition is simulated. The results verify the stabilizing effect of the sheet structure, and the minimum conformational cap length that can stabilize the growth is demonstrated to be two dimers. Then, we show that the conformational cap can function independently of the GTP cap, signifying the pivotal role of mechanical factors. Furthermore, based on our theoretical results, we describe a Tetris-like growth style of microtubules: the stochastic tubulin assembly is regulated by energy and harmonized with the seam zipping such that the sheet keeps a practically constant length during growth.

  17. Pseudobond parameters for QM/MM studies involving nucleosides, nucleotides, and their analogs

    SciTech Connect (OSTI)

    Chaudret, Robin [Duke University, North Carolina] [Duke University, North Carolina; Parks, Jerry M [ORNL] [ORNL; Yang, Weitao [Duke University, North Carolina] [Duke University, North Carolina

    2013-01-01T23:59:59.000Z

    In biological systems involving nucleosides, nucleotides, or their respective analogs, the ribose sugar moiety is the most common reaction site, for example, during DNA replication and repair. How- ever, nucleic bases, which comprise a sizable portion of nucleotide molecules, are usually unreactive during such processes. In quantum mechanical/molecular simulations of nucleic acid reactivity, it may therefore be advantageous to describe specific ribosyl or ribosyl phosphate groups quantum me- chanically and their respective nucleic bases with a molecular mechanics potential function. Here, we have extended the pseudobond approach to enable quantum mechanical/molecular mechanical simulations involving nucleotides, nucleosides, and their analogs in which the interface between the two subsystems is located between the sugar and the base, namely, the C(sp3) N(sp2) bond. The pseudobond parameters were optimized on a training set of 10 molecules representing several nu- cleotide and nucleoside bases and analogs, and they were then tested on a larger test set of 20 diverse molecules. Particular emphasis was placed on providing accurate geometries and electrostatic prop- erties, including electrostatic potential, natural bond orbital (NBO) and atoms in molecules (AIM) charges and AIM first moments. We also tested the optimized parameters on five nucleotide and nu- cleoside analogues of pharmaceutical relevance and a small polypeptide (triglycine). Accuracy was maintained for these systems, which highlights the generality and transferability of the pseudobond approach. 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772182

  18. Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through Deuterium Exchange

    E-Print Network [OSTI]

    Crofts, Antony R.

    Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through them. The strength of interactions indicates that the protons are involved in hydrogen bonds with SQ. The hyperfine cou- plings differ from values typical for in-plane hydrogen bonds previously observed in model

  19. To examine how the dynamics of recall processes are affected by the control processes involved with search termination, to study

    E-Print Network [OSTI]

    Dougherty, Michael

    involved with search termination, to study the implications of these control processes for the development at understanding the metacognitive control processes involved with the decision to terminate memory search. Specifically, research examines the impact of search termination decisions on the natural retrieval dynamics

  20. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    SciTech Connect (OSTI)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 ?g/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ? Endothelial HO1 is upregulated by ozonated plasma ? This activation is induced by NRF2 and it is ERK independent. ? 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ? Ozonated plasma induced a hormetic effect ? Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  1. Pore scale modeling of reactive transport involved in geologic CO2 sequestration

    SciTech Connect (OSTI)

    Kang, Qinjin [Los Alamos National Laboratory; Lichtner, Peter C [Los Alamos National Laboratory; Viswanathan, Hari S [Los Alamos National Laboratory; Abdel-fattah, Amr I [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    We apply a multi-component reactive transport lattice Boltzmann model developed in previolls studies to modeling the injection of a C02 saturated brine into various porous media structures at temperature T=25 and 80 C. The porous media are originally consisted of calcite. A chemical system consisting of Na+, Ca2+, Mg2+, H+, CO2(aq), and CI-is considered. The fluid flow, advection and diHusion of aqueous species, homogeneous reactions occurring in the bulk fluid, as weB as the dissolution of calcite and precipitation of dolomite are simulated at the pore scale. The effects of porous media structure on reactive transport are investigated. The results are compared with continuum scale modeling and the agreement and discrepancy are discussed. This work may shed some light on the fundamental physics occurring at the pore scale for reactive transport involved in geologic C02 sequestration.

  2. Involvement of calcium-sensing receptor in ischemia/reperfusion-induced apoptosis in rat cardiomyocytes

    SciTech Connect (OSTI)

    Zhang Weihua [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Fu Songbin [Department of Genetics, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Lu Fanghao [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)]. E-mail: lufanghao1973@yahoo.com.cn; Wu Bo [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Gong Dongmei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Lv Yanjie [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Zhao Yajun [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li Quanfeng [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Wang Rui [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Department of Biology, Lakehead University, Thunder Bay, Ont., P7B5E1 (Canada); Yang Baofeng [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Xu Changqing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China) and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China)]. E-mail: xucq@163.com

    2006-09-08T23:59:59.000Z

    The calcium-sensing receptor (CaR) is a seven-transmembrane G-protein coupled receptor, which activates intracellular effectors, for example, it causes inositol phosphate (IP) accumulation to increase the release of intracellular calcium. Although intracellular calcium overload has been implicated in the cardiac ischemia/reperfusion (I/R)-induced apoptosis, the role of CaR in the induction of apoptosis has not been fully understood. This study tested the hypothesis that CaR is involved in I/R cardiomyocyte apoptosis by increasing [Ca{sup 2+}]{sub i}. The isolated rat hearts were subjected to 40-min ischemia followed by 2 h of reperfusion, meanwhile GdCl{sub 3} was added to reperfusion solution. The expression of CaR increased at the exposure to GdCl{sub 3} during I/R. By laser confocal microscopy, it was observed that the intracellular calcium was significantly increased and exhibited a collapsed {delta}{psi} {sub m}, as monitored by 5,5',6,6'-tetrachloro-1,1',3,3'- tetraethylbenzimidazolcarbocyanine iodide (JC-1) during reperfusion with GdCl{sub 3}. Furthermore, the number of apoptotic cells was significantly increased as shown by TUNEL assay. Typical apoptotic cells were observed with transmission electron microscopy in I/R with GdCl{sub 3} but not in the control group. The expression of cytosolic cytochrome c and activated caspase-9 and caspase-3 was significantly increased whereas the expression of mitochondrial cytochrome c significantly decreased in I/R with GdCl{sub 3} in comparison to the control. In conclusion, these results suggest that CaR is involved in the induction of cardiomyocyte apoptosis during ischemia/reperfusion through activation of cytochrome c-caspase-3 signaling pathway.

  3. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway

    SciTech Connect (OSTI)

    Zhang, Huijuan; Tan, Shi; Wang, Juan; Chen, Shana; Quan, Jing; Xian, Jingrong; Zhang, Shuai shuai; He, Jingang; Zhang, Ling, E-mail: lingzhang@cqmu.edu.cn

    2014-01-01T23:59:59.000Z

    The RNA-binding protein Musashi2 (Msi2) has been identified as a master regulator within a variety of stem cell populations via the regulation of translational gene expression. A recent study has suggested that Msi2 is strongly expressed in leukemic cells of acute myeloid leukemia patients, and elevated Msi2 is associated with poor prognosis. However, the potential role of Msi2 in leukemogenesis is still not well understood. Here, we investigated the effect of Msi2 knockdown on the biological properties of leukemic cells. High expression of Msi2 was found in K562 and KG-1a leukemic cell lines, and low expression was observed in the U937 cell line. We transduced K562 cells with two independent adenoviral shRNA vectors targeting Msi2 and confirmed knockdown of Msi2 at the mRNA and protein levels. Msi2 silencing inhibited cell growth and caused cell cycle arrest by increasing the expression of p21 and decreasing the expression of cyclin D1 and cdk2. In addition, knockdown of Msi2 promoted cellular apoptosis via the upregulation of Bax and downregulation of Bcl-2 expression. Furthermore, Msi2 knockdown resulted in the inactivation of the ERK/MAPK and p38/MAPK pathways, but no remarkable change in p-AKT was observed. These data provide evidence that Msi2 plays an important role in leukemogenesis involving the MAPK signaling pathway, which indicates that Msi2 may be a novel target for leukemia treatment. - Highlights: • Knockdown of Msi2 inhibited K562 cell growth and arrested cell cycle progression. • Knockdown of Msi2 induced K562 cell apoptosis via the regulation of Bax and Bcl-2. • The MAPK pathway was involved in the process of Msi2-mediated leukemogenesis. • Our data indicate that Msi2 is a potential new target for leukemia treatment.

  4. The Orosomucoid 1 protein is involved in the vitamin D – mediated macrophage de-activation process

    SciTech Connect (OSTI)

    Gemelli, Claudia, E-mail: claudia.gemelli@unimore.it [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy); Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, 41125 Modena (Italy); Martello, Andrea; Montanari, Monica; Zanocco Marani, Tommaso; Salsi, Valentina; Zappavigna, Vincenzo; Parenti, Sandra; Vignudelli, Tatiana; Selmi, Tommaso; Ferrari, Sergio; Grande, Alexis [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy)

    2013-12-10T23:59:59.000Z

    Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties. The present study was designed to identify a possible correlation between ORM1 and Vitamin D3 (1,25(OH)2D3), a hormone exerting a widespread effect on cell proliferation, differentiation and regulation of the immune system. In particular, the data described here indicated that ORM1 is a 1,25(OH)2D3 primary response gene, characterized by the presence of a VDRE element inside the 1 kb sequence of its proximal promoter region. This finding was demonstrated with gene expression studies, Chromatin Immunoprecipitation and luciferase transactivation experiments and confirmed by VDR full length and dominant negative over-expression. In addition, several experiments carried out in human normal monocytes demonstrated that the 1,25(OH)2D3 – VDR – ORM1 pathway plays a functional role inside the macrophage de-activation process and that ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. - Highlights: • ORM1 is a Vitamin D primary response gene. • VD and its receptor VDR are involved in the de-activation process mediated by human resident macrophages. • The signaling pathway VD-VDR-ORM1 plays an important role in the control of macrophage de-activation process. • ORM1 may be defined as a signaling molecule implicated in the maintenance of tissue homeostasis and remodeling.

  5. 6/6/2014 1 of 6 OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals

    E-Print Network [OSTI]

    Kay, Mark A.

    OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals I. OVERVIEW Hazardous Chemicals: Known or suspect carcinogens, reproductive toxins or other highly toxic substances (e. Reference the SU Chemical Hygiene Plan for hazardous chemical definitions. Potential Exposures: Research

  6. Interactions among College and University Faculty and Students Involved in Academic Student Organizations: An Analysis of Qualitative and Quantitative Engagement

    E-Print Network [OSTI]

    Holzweiss, Peggy Carol

    2011-10-21T23:59:59.000Z

    The purpose of this study was to describe what kind of student-faculty interactions are occurring in the context of academic student organizations as well as identify the quality and quantity of such interactions and what factors are involved...

  7. Supply chain management (SCM) involves the management of materials and information across the entire supply chain. This includes raw material

    E-Print Network [OSTI]

    Calgary, University of

    Supply chain management (SCM) involves the management of materials and information across this concentration will be required to take three core courses: Materials and Supply Chain Management, Transportation Purchasing identify global sources of materials, select vendors, and manage negotiati

  8. The Effects of an Intervention to Foster a Caring and Task-Involving Climate at a University Recreation Center

    E-Print Network [OSTI]

    Brown, Theresa Clare

    2011-04-21T23:59:59.000Z

    using constructs from the POMS (depression, anxiety, fearful, fatigue, hostility; Usala & 18 Hertzog, 1989). An advantage of the instruments selected is there flexibility for the researcher to 19 indicate time frame (Pressman & Cohen, 2005...-Being, Self-Assuredness, Attentiveness) 6 were positively related to the task-involving climate. All but fatigue of the negative mood states 7 (i.e., Depressed, Anxiety, Hostility, Fearful) were positively associated to the ego-involving 8 climate...

  9. Elementary Act of Consciousness or Cycle of Mind, involving Distant and Nonlocal Interaction

    E-Print Network [OSTI]

    Alex Kaivarainen

    2007-09-11T23:59:59.000Z

    Each macroscopic process can be subdivided on the quantum and classical stages. Particularly, the quantum stages of Cycle of Mind involves:1) the stimulation of dynamic correlation between water clusters in the same and remote microtubules (MTs) in state of mesoscopic Bose condensation (mBC) by phonons (acoustic waves) and by librational IR photons (electromagnetic-EM waves) distant exchange; 2) the transition from distant EM interaction between remote MTs to nonlocal quantum interaction, induced by IR photons exchange between clusters, the clusters Virtual Replicas multiplication (VRM) and virtual guides (VirG) formation between elementary particles of remote coherent water molecules. This process represents transition from mesoscopic Bose condensation to macroscopic nonuniform semi-virtual Bose condensation (VirBC) (Kaivarainen, 2006, http://arxiv.org/abs/physics/0207027); 3) the collapsing of corresponding macroscopic wave function, as a result of the optical bistability of the entangled water clusters and their disassembly due to librational photons pumping, shifting clusters to less stable state; 4) turning the clusterphilic interaction between water clusters in the open state of cavities between alpha and beta tubulins to hydrophobic one and the in-phase shift of these cavities to the closed state due to clusters disassembly (Kaivarainen, http://arxiv.org/abs/physics/0102086). The classical stages of our Hierarchic model of elementary act of Cycle of Mind are analyzed in detail.

  10. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19T23:59:59.000Z

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  11. Depletion of bovine pituitary prolactin by cysteamine involves a thiol:disulfide mechanism

    SciTech Connect (OSTI)

    Lorenson, M.Y.; Jacobs, L.S.

    1984-10-01T23:59:59.000Z

    Cysteamine (2-aminoethanethiol (CySH)) reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily assayable, releasable PRL. This would represent a previously unrecognized mechanism for secretory regulation. We undertook the present study to identify the sites involved in the loss of measurable PRL (depletion) induced by cysteamine. The disulfide cystamine was ineffective on secretory granules unless combined with reduced glutathione, indicating the generation of the active CySH-thiol form. Pretreatment of granules with thiol-blocking agents resulted in dose-dependent enhancement of CySH inhibition, achieving nearly complete inhibition with 5 mM iodoacetamide. In contrast, pretreatment with reduced glutathione or dithiothreitol, respectively, impaired or abolished the CySH effect. These data suggest that the mechanism by which CySH causes PRL depletion is mediated by granule disulfides and the -SH of CySH. The regulation of thiol:disulfide equilibria appears to be an important determinant of the detectability of PRL storage forms and of their secretion.

  12. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis

    SciTech Connect (OSTI)

    Pauly, Markus; Sorensen, Susanne Oxenboll; Harholt, Jesper; Geshi, Naomi; Sakuragi, Yumiko; Moller, Isabel; Zandleven, Joris; Bernal, Adriana J.; Jensen, Niels Bjerg; Sorensen, Charlotte; Jensen, Jacob K.; Beldman, Gerrit; Willats, William G.T.; Scheller, Henrik

    2009-08-19T23:59:59.000Z

    Xylogalacturonan (XGA) is a class of pectic polysaccharide found in plant cell walls. The Arabidopsis thaliana locus At5g33290 encodes a predicted Type II membrane protein, and insertion mutants of the At5g33290 locus had decreased cell wall xylose. Immunological studies, enzymatic extraction of polysaccharides, monosaccharide linkage analysis, and oligosaccharide mass profiling were employed to identify the affected cell wall polymer. Pectic XGA was reduced to much lower levels in mutant than in wild-type leaves, indicating a role of At5g33290 in XGA biosynthesis. The mutated gene was designated xylogalacturonan deficient1 (xgd1). Transformation of the xgd1-1 mutant with the wild-type gene restored XGA to wild-type levels. XGD1 protein heterologously expressed in Nicotiana benthamiana catalyzed the transfer of xylose from UDP-xylose onto oligogalacturonides and endogenous acceptors. The products formed could be hydrolyzed with an XGA-specific hydrolase. These results confirm that the XGD1 protein is a XGA xylosyltransferase. The protein was shown by expression of a fluorescent fusion protein in N. benthamiana to be localized in the Golgi vesicles as expected for a glycosyltransferase involved in pectin biosynthesis.

  13. From public participation to stakeholder involvement: The rocky road to more inclusiveness

    SciTech Connect (OSTI)

    Peelle, E.

    1995-07-01T23:59:59.000Z

    Surviving always at the edge of extinction, public participation in environmental decision making has an uncertain and problematic history. From its emergence from the urban planning and delivery system efforts of the 1960s to many siting and non-siting uses today, it remains a battleground, with few successes and many failures. While some compelling structural, organizational and cultural explanations for this state of affairs exist, the author offers a further one--a too-limited definition and vision of public participation. One then can argue for a more inclusive process such as stakeholder involvement (SI) to enable a more viable approach to decision making. One can argue that the narrow conceptualization offered in the term public participation (PP) is partly responsible for the meager results of decades of efforts by earnest practitioners. Because of the limited, unique, and self-selected publics that respond to the major PP mechanisms such as public hearings, PP has become largely the province of organized activist groups and is largely accepted as such by most parties, including PP professionals. The author reviews the roles of Congress, federal agencies/proponents, local governments, activist groups and PP professionals in creating the current limited PP processes. She discusses trends and prospects for moving to broader based, more inclusive SI approaches. The emerging SI approach presents major methodological and organizational challenges, but offers the promise of outcomes more likely to be legitimated and potentially more lasting.

  14. Involvement of the transcription factor FoxM1 in contact inhibition

    SciTech Connect (OSTI)

    Faust, Dagmar; Al-Butmeh, Firas; Linz, Berenike [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany); Dietrich, Cornelia, E-mail: cdietric@uni-mainz.de [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)

    2012-10-05T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer The transcription factor FoxM1 is downregulated upon contact inhibition. Black-Right-Pointing-Pointer The decrease in FoxM1 levels occurs very likely due to inhibition of ERK activity. Black-Right-Pointing-Pointer The decrease in FoxM1 is not sufficient, but required for contact inhibition. Black-Right-Pointing-Pointer We propose a new model of contact inhibition involving pRB/E2F and FoxM1. -- Abstract: Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Although it is generally accepted that contact inhibition plays a pivotal role in maintaining tissue homeostasis, the molecular mechanisms of contact inhibition are still not fully understood. FoxM1 is known as a proliferation-associated transcription factor and is upregulated in many cancer types. Vice versa, anti-proliferative signals, such as TGF-{beta} and differentiation signals decrease FoxM1 expression. Here we investigated the role of FoxM1 in contact inhibition in fibroblasts. We show that protein expression of FoxM1 is severely and rapidly downregulated upon contact inhibition, probably by inhibition of ERK activity, which then leads to decreased expression of cyclin A and polo-like kinase 1. Vice versa, ectopic expression of FoxM1 prevents the decrease in cyclin A and polo-like kinase 1 and causes a two-fold increase in saturation density indicating loss of contact inhibition. Hence, we show that downregulation of FoxM1 is required for contact inhibition by regulating expression of cyclin A and polo-like kinase 1.

  15. Issues Involving The OSI Concept of Operation For Noble Gas Radionuclide Detection

    SciTech Connect (OSTI)

    Carrigan, C R; Sun, Y

    2011-01-21T23:59:59.000Z

    The development of a technically sound protocol for detecting the subsurface release of noble gas radionuclides is critical to the successful operation of an on site inspection (OSI) under the CTBT and has broad ramifications for all aspects of the OSI regime including the setting of specifications for both sampling and analysis equipment used during an OSI. With NA-24 support, we are investigating a variety of issues and concerns that have significant bearing on policy development and technical guidance regarding the detection of noble gases and the creation of a technically justifiable OSI concept of operation. The work at LLNL focuses on optimizing the ability to capture radioactive noble gases subject to the constraints of possible OSI scenarios. This focus results from recognizing the difficulty of detecting gas releases in geologic environments - a lesson we learned previously from the LLNL Non-Proliferation Experiment (NPE). Evaluation of a number of important noble gas detection issues, potentially affecting OSI policy, has awaited the US re-engagement with the OSI technical community. Thus, there have been numerous issues to address during the past 18 months. Most of our evaluations of a sampling or transport issue necessarily involve computer simulations. This is partly due to the lack of OSI-relevant field data, such as that provided by the NPE, and partly a result of the ability of LLNL computer-based models to test a range of geologic and atmospheric scenarios far beyond what could ever be studied in the field making this approach very highly cost effective. We review some highlights of the transport and sampling issues we have investigated during the past year. We complete the discussion of these issues with a description of a preliminary design for subsurface sampling that is intended to be a practical solution to most if not all the challenges addressed here.

  16. Public Involvement Plan Public Involvement Plan

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHASeptember 2010 |ofDepartment ofPart 1021 | DepartmentofAPublic

  17. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    SciTech Connect (OSTI)

    Houseworth, Jim; Rutqvist, Jonny; Asahina, Daisuke; Chen, Fei; Vilarrasa, Victor; Liu, Hui-Hai; Birkholzer, Jens

    2013-11-06T23:59:59.000Z

    Nuclear waste programs outside of the US have focused on different host rock types for geological disposal of high-level radioactive waste. Several countries, including France, Switzerland, Belgium, and Japan are exploring the possibility of waste disposal in shale and other clay-rich rock that fall within the general classification of argillaceous rock. This rock type is also of interest for the US program because the US has extensive sedimentary basins containing large deposits of argillaceous rock. LBNL, as part of the DOE-NE Used Fuel Disposition Campaign, is collaborating on some of the underground research laboratory (URL) activities at the Mont Terri URL near Saint-Ursanne, Switzerland. The Mont Terri project, which began in 1995, has developed a URL at a depth of about 300 m in a stiff clay formation called the Opalinus Clay. Our current collaboration efforts include two test modeling activities for the FE heater test and the HG-A leak-off test. This report documents results concerning our current modeling of these field tests. The overall objectives of these activities include an improved understanding of and advanced relevant modeling capabilities for EDZ evolution in clay repositories and the associated coupled processes, and to develop a technical basis for the maximum allowable temperature for a clay repository. The R&D activities documented in this report are part of the work package of natural system evaluation and tool development that directly supports the following Used Fuel Disposition Campaign (UFDC) objectives: ? Develop a fundamental understanding of disposal-system performance in a range of environments for potential wastes that could arise from future nuclear-fuel-cycle alternatives through theory, simulation, testing, and experimentation. ? Develop a computational modeling capability for the performance of storage and disposal options for a range of fuel-cycle alternatives, evolving from generic models to more robust models of performance assessment. For the purpose of validating modeling capabilities for thermal-hydro-mechanical (THM) processes, we developed a suite of simulation models for the planned full-scale FE Experiment to be conducted in the Mont Terri URL, including a full three-dimensional model that will be used for direct comparison to experimental data once available. We performed for the first time a THM analysis involving the Barcelona Basic Model (BBM) in a full three-dimensional field setting for modeling the geomechanical behavior of the buffer material and its interaction with the argillaceous host rock. We have simulated a well defined benchmark that will be used for codeto- code verification against modeling results from other international modeling teams. The analysis highlights the complex coupled geomechanical behavior in the buffer and its interaction with the surrounding rock and the importance of a well characterized buffer material in terms of THM properties. A new geomechanical fracture-damage model, TOUGH-RBSN, was applied to investigate damage behavior in the ongoing HG-A test at Mont Terri URL. Two model modifications have been implemented so that the Rigid-Body-Spring-Network (RBSN) model can be used for analysis of fracturing around the HG-A microtunnel. These modifications are (1) a methodology to compute fracture generation under compressive stress conditions and (2) a method to represent anisotropic elastic and strength properties. The method for computing fracture generation under compressive load produces results that roughly follow trends expected for homogeneous and layered systems. Anisotropic properties for the bulk rock were represented in the RBSN model using layered heterogeneity and gave bulk material responses in line with expectations. These model improvements were implemented for an initial model of fracture damage at the HG-A test. While the HG-A test model results show some similarities with the test observations, differences between the model results and observations remain.

  18. Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of

    E-Print Network [OSTI]

    Radeloff, Volker C.

    Global trade in dairy products involves complex and con- tentious issues. Viewed broadly from the perspective of "society," there are large benefits from liberalizing trade. Viewed narrowly from the perspective of dairy producers, liberalized trade is desirable only if it expands exports and reduces imports

  19. Project Brief: These works, part of the project to complete the RSM and Bessemer Buildings, involve refurbishment of level 3

    E-Print Network [OSTI]

    Project Brief: These works, part of the project to complete the RSM and Bessemer Buildings, involve London and acts as a focus for interdisciplinary research into nanoscale materials. It attracts academics in this field, fuelled by the prospect of a new generation of high performance materials with applications

  20. Abstract--Network security against possible attacks involves making decisions under uncertainty. Not only may one be

    E-Print Network [OSTI]

    ], security in wireless networks [12], [13] and cyber-security [14], [15], [16]. In [17] the readers can find1 Abstract--Network security against possible attacks involves making decisions under uncertainty for a further DDoS (Distributed Denial of Service) botnet attack on servers). Due to limited defense

  1. Abstract --The growth of non-conventional renewable energies involves a new challenge for optimal network expansion. A better

    E-Print Network [OSTI]

    Catholic University of Chile (Universidad Católica de Chile)

    1 Abstract -- The growth of non-conventional renewable energies involves a new challenge and implementation of policies to develop Non-Conventional Renewable Energies (NCRE), they can be seen as a mechanism for optimal network expansion. A better integration of renewables will be allowed by determining transmission

  2. Japan, EU adamant about their proposals to host ITER, put off negotiations to next year; Joint construction plan involving Japan,

    E-Print Network [OSTI]

    Japan, EU adamant about their proposals to host ITER, put off negotiations to next year; Joint construction plan involving Japan, U.S. South Korea also emerging NIHON KEIZAI, December 20, 2004 Japan are likely to enter a crucial stage early in the next year. In addition to Japan and the EU, the United

  3. Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

    E-Print Network [OSTI]

    Linial, Michal

    Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release kinase (ERK)/mitogen-activated protein kinase (MAPK) in pardaxin-induced dopamine (DA) release DA release. Time course exper- iments indicated that PX, at nontoxic concentrations, stimu- lated ERK

  4. Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping

    E-Print Network [OSTI]

    TDG Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping and receiving. All receiving of Dangerous Goods for the Science in Departmental Offices or labs. How do you know if the package is a dangerous goods shipment? Parcels containing

  5. 162 Electrical and Computer Engineering 163 Courses and projects that actively involve them in their own education and

    E-Print Network [OSTI]

    Richards-Kortum, Rebecca

    162 Electrical and Computer Engineering 163 · Courses and projects that actively involve them · A broad education outside of engineering and science that emphasizes the role of electrical and computer of technology Graduate and undergraduate programs in electrical and computer engineering offer concentrations

  6. "The Greek community will strive for excellence in scholarship, service, leadership, involvement, diversity, building community, and brotherhood/sisterhood."

    E-Print Network [OSTI]

    Linhardt, Robert J.

    fully support our project. As a model for chapter house budgeting and house operation, as well 1255 students) are leading the sustainability effort on campus with their Green Greeks vision and plan involved in class projects and coursework, and increase the sustainability of the Rensselaer community

  7. What is Your Environmental Wellness? The environmental dimension involves accepting the impact we have on our world and doing something

    E-Print Network [OSTI]

    sprays. _____ 7. I do not litter. _____ 8. I volunteer my time for environmental conservation projectsWhat is Your Environmental Wellness? The environmental dimension involves accepting the impact we points _____ 1. I consciously conserve energy (electricity, heat, light, water, etc.) in my place

  8. CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax Production

    E-Print Network [OSTI]

    Kunst, Ljerka

    CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax surfaces of land plants. It is composed of a cutin polymer matrix and waxes. Cuticular waxes are complex and characterization of CER4, a wax bio- synthetic gene from Arabidopsis (Arabidopsis thaliana). Arabidopsis cer4

  9. TERC Research in the Chilean Patagonia TERC is involved in a collaborative research effort with the EULA Center of the

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    TERC Research in the Chilean Patagonia TERC is involved in a collaborative research effort of the Chilean Patagonia. The lakes, rivers, glaciers, wetlands and other aquatic environments of the Chilean Patagonia offer a globally unique opportunity for science. They represent the most undisturbed aquatic

  10. Control of Major-Accident Hazards Involving Land Transmission Charlotte BOUISSOU, Project Manager for Pipelines Risk Assessment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    aims to help authorities to balance the requirement of the new pipeline regulation with regardsControl of Major-Accident Hazards Involving Land Transmission Pipelines Charlotte BOUISSOU, Project Manager for Pipelines Risk Assessment Sandrine DESCOURRIERE, Project Manager for Plants Risk Assessment

  11. Abstract--This paper reports on studies involving brain-machine interfaces (BMIs) that provide near-instantaneous

    E-Print Network [OSTI]

    Guenther, Frank

    Abstract--This paper reports on studies involving brain- machine interfaces (BMIs) that provide output. I. INTRODUCTION ECENT years have seen the development of brain- machine interfaces (BMIs or electroencephalography (EEG). In the current paper we focus on a specific subset of brain-machine interfaces: those aimed

  12. Development and application of a hybrid method involving interpolation and ab initio calculations for the determination of transition states

    E-Print Network [OSTI]

    Bell, Alexis T.

    optimization P-RFO method. Such methods tend to work well if information about the potential energy surfaceDevelopment and application of a hybrid method involving interpolation and ab initio calculations scheme was used to estimate the energy and gradient, thereby reducing the calls to the quantum mechanical

  13. Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate regulation of chlorophyll a oxygenase (CAO)

    E-Print Network [OSTI]

    Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate and that of the Lhcb genes in the model organism Dunaliella salina. Among the chlorophyll biosynthesis enzymes tested are a dynamic compensation response (Melis, 1996; 1998). When HL-acclimated cells of D. salina were shifted

  14. Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP, Bruce D. Hammock, Elizabeth Murphy, Darryl C. Zeldin Abstract--Human CYP2J2 is abundant in heart and its eicosanoid products in the heart remains unknown. Transgenic mice with cardiomyocyte

  15. Most fish have a forward undulatory swimming mechanism that involves a kinematic propulsive wave travelling down the

    E-Print Network [OSTI]

    D'Août, Kristiaan

    Most fish have a forward undulatory swimming mechanism that involves a kinematic propulsive wave backwards in a similar way. We compared the kinematics (wave speed, cycle frequency, amplitude, local in the direction opposite to that of swimming. We observe two major kinematic differences. First, the slope of wave

  16. A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved in Differentiation of Trypomastigotes to

    E-Print Network [OSTI]

    Singer, Randall

    A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved C (PI- PLC) is an important component of the inositol phos- phate/diacylglycerol signaling pathway. A newly discov- ered Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N terminus, targeted

  17. Nonadiabatic dynamics for processes involving multiple avoided curve crossings: Double proton transfer and proton-coupled electron transfer

    E-Print Network [OSTI]

    Hammes-Schiffer, Sharon

    Nonadiabatic dynamics for processes involving multiple avoided curve crossings: Double proton transfer and proton-coupled electron transfer reactions Jian-Yun Fang and Sharon Hammes June 1997; accepted 26 August 1997 The extension of the surface hopping method ``molecular dynamics

  18. Thomas Meyer Basic Infobase Change Abstract. Generalisations of theory change involving arbitrary sets of w s instead of

    E-Print Network [OSTI]

    Meyer, Tommie

    Thomas Meyer Basic Infobase Change Abstract. Generalisations of theory change involving arbitrary these lines by Meyer et al. 15]. We take an infobase as a nite sequence of w s, with each element Kluwer Academic Publishers. Printed in the Netherlands. #12;216 T. Meyer In this paper we propose a form

  19. Using Software Development Standards to Analyse Accidents Involving Electrical, Electronic or Programmable, Electronic Systems: The Blade Mill PLC Case Study

    E-Print Network [OSTI]

    Johnson, Chris

    -1- Using Software Development Standards to Analyse Accidents Involving Electrical, Electronic developed by the US Department of Energy (1992). The intention is that both the lightweight flowcharts's (HSE) mission is to ensure that risks to people's health and safety from work activities are properly

  20. ECOdriving - Widespread Implementation for Learner Drivers and...

    Open Energy Info (EERE)

    Focus Area: Fuels & Efficiency Topics: Best Practices Website: www.ecodrive.org Transport Toolkit Region(s): Europe Related Tools GIZ Sourcebook Module 5g: Urban Transport...

  1. Raman accumulator as a fusion laser driver

    DOE Patents [OSTI]

    George, E.V.; Swingle, J.C.

    1982-03-31T23:59:59.000Z

    Apparatus for simultaneous laser pulse amplification and compression, using multiple pass Raman scattering in one Raman cell and pulse switchout from the optical cavity through use of a dichroic device associated with the Raman cell.

  2. DESCRIPTION OF ACCIDENT MSU DRIVERS SIGNATURE

    E-Print Network [OSTI]

    Dyer, Bill

    of Commercial Policy Number) Motor vehicles that are owned, rented, leased, or loaned to Montana State's Name: MSU VEHICLE (VEHICLE #1) Issued Citation: YES NO Explain: Department: Phone: 994 - Vehicle Owner: Use of Vehicle: Vehicle: Make Model Year VIN: Plate Number: State: Description of Damage: Safety

  3. The Jefferson lab FEL driver ERLs

    SciTech Connect (OSTI)

    Douglas, David R. [JLAB; Tennant, Christopher D. [JLAB

    2013-11-01T23:59:59.000Z

    Jefferson Lab has - for over a decade - been operating high power IR and UV FELs using CW energy recovering linacs based on DC photocathode electron sources and CEBAF SRF technology. These machines have unique combinations of beam quality, power, and operational flexibility, and thus offer significant opportunity for experiments that use low and medium energy (several tens - few hundreds of MeV) electron beams. We will describe the systems and detail their present and near-term (potential) performance. Recent internal-target analysis and validation testing will be discussed, and schemes for single- and two-pass fixed target operation described. An introduction to subsequent discussions of beam quality and upgrade paths to polarized operation/higher energy will be given.

  4. The Jefferson lab FEL driver ERLs

    SciTech Connect (OSTI)

    Douglas, David R.; Tennant, Christopher D. [Jefferson Lab, Newport News, VA 23606 (United States)

    2013-11-07T23:59:59.000Z

    Jefferson Lab has - for over a decade - been operating high power IR and UV FELs using CW energy recovering linacs based on DC photocathode electron sources and CEBAF SRF technology. These machines have unique combinations of beam quality, power, and operational flexibility, and thus offer significant opportunity for experiments that use low and medium energy (several tens - few hundreds of MeV) electron beams. We will describe the systems and detail their present and near-term (potential) performance. Recent internal-target analysis and validation testing will be discussed, and schemes for single- and two-pass fixed target operation described. An introduction to subsequent discussions of beam quality and upgrade paths to polarized operation/higher energy will be given.

  5. Alternative Fuel Driver Training Companion Manual

    SciTech Connect (OSTI)

    Not Available

    2005-09-01T23:59:59.000Z

    Training manual serves as a companion to alternative fuel training presentations on the fueling and use of vehicles that run on compressed natural gas, biodiesel, E85, and propane.

  6. Overload protection circuit for output driver

    DOE Patents [OSTI]

    Stewart, Roger G. (Neshanic Station, NJ)

    1982-05-11T23:59:59.000Z

    A protection circuit for preventing excessive power dissipation in an output transistor whose conduction path is connected between a power terminal and an output terminal. The protection circuit includes means for sensing the application of a turn on signal to the output transistor and the voltage at the output terminal. When the turn on signal is maintained for a period of time greater than a given period without the voltage at the output terminal reaching a predetermined value, the protection circuit decreases the turn on signal to, and the current conduction through, the output transistor.

  7. Residential Prosumers: Drivers and Policy Options | Department...

    Office of Environmental Management (EM)

    In some countries, it is now more cost-effective for households to produce their own power from PV than to purchase electricity from the grid. However, a prosumer "revolution"...

  8. xDSL line driver design

    E-Print Network [OSTI]

    Zhang, Xiaoyong

    2001-01-01T23:59:59.000Z

    technology file. Architecture level design is presented first and transistor level design is presented later. The system level simulation shows that high linearity for a very large output signal is achieved with low quiescent power consumption....

  9. STATE OF ARIZONA DRIVER AUTHORIZATION FORM

    E-Print Network [OSTI]

    Rhoads, James

    of Defensive Driving Date (DDT): Leased Vehicle Completion of Defensive Driving Date (DDT): Rented Vehicle Completion of Defensive Driving Date (DDT): #12;

  10. Cyclotrons as Drivers for Precision Neutrino Measurements

    E-Print Network [OSTI]

    Adelmann, A.

    As we enter the age of precision measurement in neutrino physics, improved flux sources are required. These must have a well defined flavor content with energies in ranges where backgrounds are low and cross-section ...

  11. Hydraulic Cooling Tower Driver- The Innovation

    E-Print Network [OSTI]

    Dickerson, J. A.

    -drive eliminates these items from the drive train and puts the same electric motor HP at ground level close coupled to a hydraulic pump, filters, and oil reservoir. Hydraulic lines bring oil pressure to the hydraulic motor, which is more than 75% less weight than...

  12. Fundamental Drivers of Pacific Northwest Power Markets

    E-Print Network [OSTI]

    , utilities, power marketers, investors, and others on wholesale electricity and natural gas markets. Experts Load Transmission Thermal Hydro Wind (2005) #12;Natural Gas Capacity 6 5,000 MW of Natural Gas;Natural Gas Power Plant Production is Significantly Down 2010 to 2012 13 #12;Mid C Peak Heat Rates 14

  13. Solar Supply Chain and Market Driver Analysis

    E-Print Network [OSTI]

    Martinez, Nicholas 1990-

    2012-05-09T23:59:59.000Z

    The installed cost of a photovoltaic system has declined dramatically in the recent years (Barbose, Darghouth, & Wiser, 2011). Components of the PV system include the solar panel (module), inverter, mounting, and the wires or balance of system components...

  14. OMEGA Laser Drivers - Laboratory for Laser Energetics

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  15. TEAM 1 Drivers License.doc

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  16. Market Drivers for Biofuels | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

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  17. Drivers and Directions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197E TDrew Bittner About Us Drew Bittner -Drive

  18. Market Drivers for Biofuels | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment3311, 3312), October 2012 (MECSEnergy PlansMaterials

  19. Alternative Fuel Driver Training Companion Manual

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  20. Sandia National Laboratories: Pollution Prevention: Regulatory Drivers

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementingnpitche Home AboutMeeting: ProgramFebruaryJune 26,Recycling