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Sample records for involving older drivers

  1. Projecting Fatalities in Crashes Involving Older Drivers, 2000-2025

    SciTech Connect (OSTI)

    Hu, P.S.

    2001-03-23

    As part of this research effort, we developed a new methodology for projecting elderly traffic crash fatalities. This methodology separates exposure to crashes from crash risk per se, and further divides exposure into two components, the number of miles driven and the likelihood of being a driver. This component structure permits conceptually different determinants of traffic fatalities to be projected separately and has thorough motivation in behavioral theory. It also permits finer targeting of particular aspects of projections that need improvement and closer linking of projections to possible policy instruments for influencing them.

  2. Fact #922: April 25, 2016 Share of Older Population Holding Driver's

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Licenses is Up and Share of Younger Population Holding Driver's Licenses is Down | Department of Energy 2: April 25, 2016 Share of Older Population Holding Driver's Licenses is Up and Share of Younger Population Holding Driver's Licenses is Down Fact #922: April 25, 2016 Share of Older Population Holding Driver's Licenses is Up and Share of Younger Population Holding Driver's Licenses is Down SUBSCRIBE to the Fact of the Week Examining the share of population holding driver's licenses in

  3. Fact #922: April 25, 2016 Share of Older Population Holding Driver...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    922: April 25, 2016 Share of Older Population Holding Driver's Licenses is Up and Share of Younger Population Holding Driver's Licenses is Down Fact 922: April 25, 2016 Share of ...

  4. LANL GPIB Driver

    Energy Science and Technology Software Center (OSTI)

    2004-04-15

    This driver code adds a GPIB infrastructure and API features to 2.6 series Linux kernels. Currently supported hardware is National Instruments PCI-GPIB cards built on either the TNT4882 controller chip, or the TNT5004 controller chip. This driver is an improvement over previous GPIB drivers in Linux because it has all the features of the GPL, high performance DMA, supports Linux 2.6 and the new driver model, and has a cleaner API than the previous drivers.more » GPIB is the "general purpose interface bus", commonly used to control oscilloscopes, digital multimeters, function generators, and other electronic test equipment.« less

  5. Market Drivers for Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    MARKET DRIVERS FOR BIOFUELS Brian Duff Chief Engineer Bioenergy Technologies Office 3 rd Annual MSW to Biofuels Summit, Orlando, FL February 20-21, 2013 2 | Bioenergy Technologies ...

  6. Drivers, Trends and Mitigation

    SciTech Connect (OSTI)

    Blanco, Arthur S.; Gerlagh, Reyer; Suh, Sangwon; Barrett, John A.; de Coninck, Heleen; Diaz Morejon, Cristobal Felix; Mathur, Ritu; Nakicenovic, Nebojsa; Ahenkorah, Alfred Ofosu; Pan, Jiahua; Pathak, Himanshu; Rice, Jake; Richels, Richard G.; Smith, Steven J.; Stern, David; Toth, Ferenc L.; Zhou, Peter

    2014-12-01

    Chapter 5 analyzes the anthropogenic greenhouse gas (GHG) emission trends until the present and the main drivers that explain those trends. The chapter uses different perspectives to analyze past GHG-emissions trends, including aggregate emissions flows and per capita emissions, cumulative emissions, sectoral emissions, and territory-based vs. consumption-based emissions. In all cases, global and regional trends are analyzed. Where appropriate, the emission trends are contextualized with long-term historic developments in GHG emissions extending back to 1750.

  7. Robotic Intelligence Kernel: Driver

    Energy Science and Technology Software Center (OSTI)

    2009-09-16

    The INL Robotic Intelligence Kernel-Driver is built on top of the RIK-A and implements a dynamic autonomy structure. The RIK-D is used to orchestrate hardware for sensing and action as well as software components for perception, communication, behavior and world modeling into a single cognitive behavior kernel that provides intrinsic intelligence for a wide variety of unmanned ground vehicle systems.

  8. Sandia Material Model Driver

    Energy Science and Technology Software Center (OSTI)

    2005-09-28

    The Sandia Material Model Driver (MMD) software package allows users to run material models from a variety of different Finite Element Model (FEM) codes in a standalone fashion, independent of the host codes. The MMD software is designed to be run on a variety of different operating system platforms as a console application. Initial development efforts have resulted in a package that has been shown to be fast, convenient, and easy to use, with substantialmore » growth potential.« less

  9. ECOdriving - Widespread Implementation for Learner Drivers and...

    Open Energy Info (EERE)

    programs for licensed drivers in 13 European countries. ECOWILL also promotes the education of eco-driving for learner drivers. This website provides information about...

  10. Proton driver power supply system

    SciTech Connect (OSTI)

    C. Jach and D. Wolff

    2002-06-03

    This paper describes magnet power supply system for a proposed Proton Driver at Fermilab. The magnet power supply system consists of resonant dipole/quadrupole power supply system, quadrupole tracking, dipole correction (horizontal and vertical) and sextupole power supply systems. This paper also describes preliminary design of the power distribution system supplying 13.8 kV power to all proton Driver electrical systems.

  11. UWB dual burst transmit driver

    DOE Patents [OSTI]

    Dallum, Gregory E.; Pratt, Garth C.; Haugen, Peter C.; Zumstein, James M.; Vigars, Mark L.; Romero, Carlos E.

    2012-04-17

    A dual burst transmitter for ultra-wideband (UWB) communication systems generates a pair of precisely spaced RF bursts from a single trigger event. An input trigger pulse produces two oscillator trigger pulses, an initial pulse and a delayed pulse, in a dual trigger generator. The two oscillator trigger pulses drive a gated RF burst (power output) oscillator. A bias driver circuit gates the RF output oscillator on and off and sets the RF burst packet width. The bias driver also level shifts the drive signal to the level that is required for the RF output device.

  12. Eaton AF5000+Genesis Communication Driver

    Energy Science and Technology Software Center (OSTI)

    1995-05-25

    Communication driver allows the Genesis Control Series software to interact with Eaton AF5000+ frequency drives via RS-232 communications. All Eaton AF5000+ parameters that support communications are supported by the Genesis driver. Multidrop addressing to multiple units is available with the Genesis communication driver.

  13. Drivers of Future Energy Demand

    U.S. Energy Information Administration (EIA) Indexed Site

    Drivers of Future Energy Demand in China Asian Energy Demand Outlook 2014 EIA Energy Conference July 14, 2014 Valerie J. Karplus MIT Sloan School of Management 2 www.china.org.cn www.flickr.com www.wikimedia.org globalchange.mit.edu Global Climate Change Human Development Local Pollution Industrial Development & Resource Needs How to balance? 0 500 1000 1500 2000 2500 3000 3500 4000 1981 1991 2001 2011 Non-material Sectors/Other Construction Commercial consumption Residential consumption

  14. Market Drivers for Biofuels | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Market Drivers for Biofuels Market Drivers for Biofuels This presentation, entitled "Market Drivers for Biofuels," was given at the Third Annual MSW to Biofuels Summit in February, 2013, by Brian Duff. duff_msw_to_biofuels_summit.pdf (2.42 MB) More Documents & Publications Office of the Biomass Program Educational Opportunities in Bioenergy Intro Webinar Webinar: Using the New Bioenergy KDF for Data Discovery and Research Sustainability for the Global Biofuels Industry: Minimizing

  15. Physics at an upgraded Fermilab proton driver

    SciTech Connect (OSTI)

    Geer, S.; /Fermilab

    2005-07-01

    In 2004 the Fermilab Long Range Planning Committee identified a new high intensity Proton Driver as an attractive option for the future, primarily motivated by the recent exciting developments in neutrino physics. Over the last few months a physics study has developed the physics case for the Fermilab Proton Driver. The potential physics opportunities are discussed.

  16. FFAG ACCELERATOR PROTON DRIVER FOR NEUTRINO FACTORY.

    SciTech Connect (OSTI)

    RUGGIERO, A.

    2005-06-21

    This paper is the summary of a conceptual study of a Proton Driver for Neutrino Factory based on the use of a Fixed-Field Alternating-Gradient (FFAG) Accelerator. The required proton energy range for an optimum neutrino production is 5 to 12 GeV. This can be accomplished with a group of three concentric rings each with 807 m circumference [1]. FFAG Accelerators [2] have the capability to accelerate charged particles over a large momentum range ({+-}30-50%) and the feature of constant bending and focusing fields. Particles can be accelerated very fast at the rate given by the accelerating field of RF cavities placed in proper locations between magnets. The performance of FFAG accelerators is to be placed between that of Super-Conducting Linear Accelerators (SCL), with which they share the fast acceleration rate, and Rapid-Cycling Synchrotrons (RCS), as they allow the beam to re-circulate over fewer revolutions. Brookhaven National Laboratory is involved in the study of feasibility of FFAG Accelerators to accelerate intense beams of protons in the GeV energy range for a variety of applications the most important of which is the Upgrade of the Alternating Gradient Synchrotron (AGS) with a new FFAG injector [3] accelerating from 400 MeV to 1.5 GeV. The ring would be housed in the AGS tunnel and has henceforth a circumference of 807 m.

  17. V-217: Microsoft Windows NAT Driver ICMP Packet Handling Denial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7: Microsoft Windows NAT Driver ICMP Packet Handling Denial of Service Vulnerability V-217: Microsoft Windows NAT Driver ICMP Packet Handling Denial of Service Vulnerability August...

  18. Renewable Energy Technology Costs and Drivers | Open Energy Informatio...

    Open Energy Info (EERE)

    Technology Costs and Drivers Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Renewable Energy Technology Costs and Drivers AgencyCompany Organization: National...

  19. Drivers and Barriers in the Current Concentrated Solar Power...

    Open Energy Info (EERE)

    Drivers and Barriers in the Current Concentrated Solar Power (CSP) Market (Webinar) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Drivers and Barriers in the Current...

  20. Driver circuit for solid state light sources

    DOE Patents [OSTI]

    Palmer, Fred; Denvir, Kerry; Allen, Steven

    2016-02-16

    A driver circuit for a light source including one or more solid state light sources, a luminaire including the same, and a method of so driving the solid state light sources are provided. The driver circuit includes a rectifier circuit that receives an alternating current (AC) input voltage and provides a rectified AC voltage. The driver circuit also includes a switching converter circuit coupled to the light source. The switching converter circuit provides a direct current (DC) output to the light source in response to the rectified AC voltage. The driver circuit also includes a mixing circuit, coupled to the light source, to switch current through at least one solid state light source of the light source in response to each of a plurality of consecutive half-waves of the rectified AC voltage.

  1. OMEGA Laser Drivers - Laboratory for Laser Energetics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drivers - Laboratory for Laser Energetics Laboratory for Laser Energetics Logo Search Home Around the Lab Past Issues Past Quick Shots About Office of the Director Map to LLE LLE ...

  2. Physics at a new Fermilab proton driver

    SciTech Connect (OSTI)

    Geer, Steve; /Fermilab

    2006-04-01

    In 2004, motivated by the recent exciting developments in neutrino physics, the Fermilab Long Range Planning Committee identified a new high intensity Proton Driver as an attractive option for the future. At the end of 2004 the APS ''Study on the Physics of Neutrinos'' concluded that the future US neutrino program should have, as one of its components, ''A proton driver in the megawatt class or above and neutrino superbeam with an appropriate very large detector capable of observing Cp violation and measuring the neutrino mass-squared differences and mixing parameters with high precision''. The presently proposed Fermilab Proton Driver is designed to accomplish these goals, and is based on, and would help develop, Linear Collider technology. In this paper the Proton Driver parameters are summarized, and the potential physics program is described.

  3. Fact #922: April 25, 2016 Share of Older Population Holding Driver...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reactor Pressure Vessel Task of Light Water Reactor Sustainability Program: Milestone Report on Materials and Machining of Specimens for the ATR-2 Experiment Fact 905: December ...

  4. Linear transformer driver for pulse generation

    DOE Patents [OSTI]

    Kim, Alexander A; Mazarakis, Michael G; Sinebryukhov, Vadim A; Volkov, Sergey N; Kondratiev, Sergey S; Alexeenko, Vitaly M; Bayol, Frederic; Demol, Gauthier; Stygar, William A

    2015-04-07

    A linear transformer driver includes at least one ferrite ring positioned to accept a load. The linear transformer driver also includes a first power delivery module that includes a first charge storage devices and a first switch. The first power delivery module sends a first energy in the form of a first pulse to the load. The linear transformer driver also includes a second power delivery module including a second charge storage device and a second switch. The second power delivery module sends a second energy in the form of a second pulse to the load. The second pulse has a frequency that is approximately three times the frequency of the first pulse. The at least one ferrite ring is positioned to force the first pulse and the second pulse to the load by temporarily isolating the first pulse and the second pulse from an electrical ground.

  5. National Needs Drivers for Nanotechnology

    SciTech Connect (OSTI)

    Yonas, G.; Picraux, S.T.

    2000-10-09

    Societal needs related to demographics, resources, and human behavior will drive technological advances over the next 20 years. Nanotechnology is anticipated to be an important enabler of these advances, and thus maybe anticipated to have significant influence on new systems approaches to solving societal problems as well as on extending current science and technology-based applications. To examine the potential implications of nanotechnology a societal needs-driven approach is taken. Thus the methodology is to present the definition of the problem, and then examine system concepts, technology issues, and promising future directions. We approach the problem definition from a national and global security perspective and identify three key areas involving the condition of the planet, the human condition, and global security. In anticipating societal issues in the context of revolutionary technologies, such as maybe enabled by nanoscience, the importance of working on the entire life cycle of any technological solution is stressed.

  6. TMACS Test Procedure TP009: Acromag Driver

    SciTech Connect (OSTI)

    Washburn, S.J.

    1994-05-31

    The TMACS Software Project Test Procedures translate the project`s acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure tests the TMACS Acromag Software Driver (Bridge Code).

  7. Drivers of Success in the Better Buildings Neighborhood Program --

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Statistical Process Evaluation Volume 3 | Department of Energy Drivers of Success in the Better Buildings Neighborhood Program -- Statistical Process Evaluation Volume 3 Drivers of Success in the Better Buildings Neighborhood Program -- Statistical Process Evaluation Volume 3 Final Report: Drivers of Success in the Better Buildings Neighborhood Program - Statistical Process Evaluation Final Evaluation Volume 3, American Recovery and Reinvestment Act of 2009, June 2015. Drivers of Success in

  8. Tank monitor and control system (TMACS) software project Westronics Driver acceptance test

    SciTech Connect (OSTI)

    Glasscock, J.A.

    1998-08-18

    The acceptance test for the Westronics driver. This driver connects the Westronics Smart Multiplexer with the TMACS monitoring system.

  9. Alternative Fuel Driver Training Companion Manual

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    EPAct Regulated Fleets Alternative Fuel Driver Training Companion Manual Notice This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use

  10. A material model driver for DYNA3D

    SciTech Connect (OSTI)

    Hallquist, J.O.; Whirley, R.G.

    1990-02-22

    This report describes a material model driver which has recently been implemented in the DYNA3D code. The material model driver allows plotting of the constitutive response predicted by a material model under a given load path. This capability is particularly useful when fitting complex material models to experimental data. The plotting capability of the material model driver facilitates comparison of the simulated material stress-strain behavior with actual material test results. 1 ref., 6 figs., 4 tabs.

  11. Vehicle Technologies Office Merit Review 2015: Gate Driver Optimizatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Gate Driver Optimization for WBG Applications Vehicle Technologies Office Merit Review ... Presentation given by Oak Ridge National Laboratory at 2015 DOE Hydrogen and Fuel Cells ...

  12. OLED Luminaire with Panel Integrated Drivers and Advanced Controls...

    Broader source: Energy.gov (indexed) [DOE]

    DC current drivers integrated with each panel, and a base station that interfaces with ... More Documents & Publications High-Performance OLED Panel and Luminaire Luminaires for ...

  13. Brazil's Biofuels Scenario: What are the Main Drivers Which will...

    Broader source: Energy.gov (indexed) [DOE]

    in Bioenergy Brazil's Biofuels Scenario: What are the Main Drivers Which will Shape Investments in the Long Term? Artur Milanez, Manager of Biofuels Department, Brazilian ...

  14. BG/Q Drivers Status | Argonne Leadership Computing Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blue GeneQ Versus Blue GeneP BGQ Drivers Status Machine Overview Machine Partitions Torus Network Data Storage & File Systems Compiling & Linking Queueing & Running Jobs Data...

  15. Microsoft Word - ContractManagementPlanningDRIVERS.doc | Department...

    Broader source: Energy.gov (indexed) [DOE]

    ContractManagementPlanningDRIVERS.doc More Documents & Publications Microsoft Word - ARRAAttachment2.doc Microsoft Word - ARRAModelWAS.doc Microsoft Word - ARRAMOModelMod.doc...

  16. High Temperature, High Voltage Fully Integrated Gate Driver Circuit...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    D.C. PDF icon ape003tolbert2010p.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Wide Bandgap Materials Smart ...

  17. High Temperature, High Voltage Fully Integrated Gate Driver Circuit...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    -- Washington D.C. PDF icon ape03marlino.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Smart Integrated Power Module ...

  18. Drivers of Success in the Better Buildings Neighborhood Program...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Neighborhood Program -- Statistical Process Evaluation Volume 3 Drivers of Success in the Better Buildings Neighborhood Program -- Statistical Process Evaluation Volume 3 ...

  19. Alternative Fuel Vehicles: What Do the Drivers Say?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    What Do the Drivers Say? For more information contact: e:mail: Public Affairs Golden, Colo., Nov. 19, 1997 -- What do the people who drive them really think about alternative fuel vehicles (AFVs)? That was the question on the table when the U.S. Department of Energy (DOE) launched a nationwide survey of federal fleet managers and AFV drivers in 1996. The answers are in Perspectives on AFVs: 1996 Federal Fleet Driver Survey. Two hundred and fifty drivers were surveyed during each quarter of 1996.

  20. Inertially confined fusion using heavy ion drivers

    SciTech Connect (OSTI)

    Herrmannsfeldt, W.B. ); Bangerter, R.O. ); Bock, R. ); Hogan, W.J.; Lindl, J.D. )

    1991-10-01

    The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF (2) Which problems are most appropriate for such collaboration (3) Can the sharing of target design information be set aside until other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.

  1. Inertially confined fusion using heavy ion drivers

    SciTech Connect (OSTI)

    Herrmannsfeldt, W.B.; Bangerter, R.O.; Bock, R.; Hogan, W.J.; Lindl, J.D.

    1991-10-01

    The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF? (2) Which problems are most appropriate for such collaboration? (3) Can the sharing of target design information be set aside until other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues? (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral? (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF? The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.

  2. Older Public Presentations | Critical Materials Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Older Public Presentations CMI leaders and scientists have given public presentations about rare earths and critical materials. Here are a few of their older presentations. CMI Kickoff Meeting Plenary Sessions, September 2013: Alex King, director: CMI Welcome Karl Gschneidner, chief science officer: CMI Overview Bruce Moyer, leader for Diversifying Supply Adam Schwartz, leader for Developing Substitutes Eric Peterson, leader for Improving Reuse and Recycling Tom Lograsso, leader for Crosscutting

  3. Can we estimate plasma density in ICP driver through electrical parameters in RF circuit?

    SciTech Connect (OSTI)

    Bandyopadhyay, M. Sudhir, Dass Chakraborty, A.

    2015-04-08

    To avoid regular maintenance, invasive plasma diagnostics with probes are not included in the inductively coupled plasma (ICP) based ITER Neutral Beam (NB) source design. Even non-invasive probes like optical emission spectroscopic diagnostics are also not included in the present ITER NB design due to overall system design and interface issues. As a result, negative ion beam current through the extraction system in the ITER NB negative ion source is the only measurement which indicates plasma condition inside the ion source. However, beam current not only depends on the plasma condition near the extraction region but also on the perveance condition of the ion extractor system and negative ion stripping. Nevertheless, inductively coupled plasma production region (RF driver region) is placed at distance (∼ 30cm) from the extraction region. Due to that, some uncertainties are expected to be involved if one tries to link beam current with plasma properties inside the RF driver. Plasma characterization in source RF driver region is utmost necessary to maintain the optimum condition for source operation. In this paper, a method of plasma density estimation is described, based on density dependent plasma load calculation.

  4. Commitment to Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Create a Sustainable Future Commitment to Public Involvement Commitment to Public Involvement LANL is committed to our neighbors August 1, 2013 Lab Director McMillan talks with...

  5. WIPP Driver Makes History, Again | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    WIPP Driver Makes History, Again WIPP Driver Makes History, Again August 31, 2011 - 12:00pm Addthis Media Contact Deb Gill www.wipp.energy.gov 575-234-7270 CARLSBAD, N.M. - A brand-new shipping package arrived at the Department of Energy's Waste Isolation Pilot Plant (WIPP) during the early evening hours of August 25, but an all-too familiar face was behind the wheel of the vehicle carrying the package. Long-time WIPP driver Randy Anderson made history, again, when he guided the new TRUPACT-III

  6. Driver performance data acquisition system for ergonomics research

    SciTech Connect (OSTI)

    Carter, R.J.; Goodman, M.J.

    1994-12-31

    A portable ergonomics data acquisition system consisting of state-of-the-art hardware being designed is described here. It will be employed to record driver, vehicle, and environment parameter data from a wide range of vehicles and trucks. The system will be unobtrusive to the driver and inconspicuous to the outside world. It will have three modes of data gathering and provide for extended periods of data collection. Modularity, flexibility, and cost will be key drivers in the development effort. The ergonomics data acquisition system project is being conducted in two phases--a feasibility study and a development, construction, and validation phase.

  7. Oil and natural gas market outlook and drivers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFS | Oil and natural gas market outlook and drivers, May 18, 2016 Global supply has ... WTI price dollars per barrel EIA expects WTI oil prices to remain low compared to recent ...

  8. Arbitrary waveform generator to improve laser diode driver performance

    DOE Patents [OSTI]

    Fulkerson, Jr, Edward Steven

    2015-11-03

    An arbitrary waveform generator modifies the input signal to a laser diode driver circuit in order to reduce the overshoot/undershoot and provide a "flat-top" signal to the laser diode driver circuit. The input signal is modified based on the original received signal and the feedback from the laser diode by measuring the actual current flowing in the laser diode after the original signal is applied to the laser diode.

  9. Science Drivers and Technical Challenges for Advanced Magnetic Resonance

    SciTech Connect (OSTI)

    Mueller, Karl T.; Pruski, Marek; Washton, Nancy M.; Lipton, Andrew S.

    2013-03-07

    This report recaps the "Science Drivers and Technical Challenges for Advanced Magnetic Resonance" workshop, held in late 2011. This exploratory workshop's goal was to discuss and address challenges for the next generation of magnetic resonance experimentation. During the workshop, participants from throughout the world outlined the science drivers and instrumentation demands for high-field dynamic nuclear polarization (DNP) and associated magnetic resonance techniques, discussed barriers to their advancement, and deliberated the path forward for significant and impactful advances in the field.

  10. Drivers of Success in the Better Buildings Neighborhood Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Final Report Drivers of Success in the Better Buildings Neighborhood Program - Statistical Process Evaluation Final Evaluation Volume 3 American Recovery and Reinvestment Act of 2009 June 2015 DOE/EE-1204 DOE/EE-1204 Final Report Drivers of Success in the Better Buildings Neighborhood Program - Statistical Process Evaluation Final Evaluation Volume 3 American Recovery and Reinvestment Act of 2009 June 2015 Funded By: Prepared By: Research Into Action, Inc. Prepared For: U.S. Department of

  11. Van Allen probes pinpoint driver of speeding electrons

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Van Allen probes pinpoint driver of speeding electrons Van Allen probes pinpoint driver of speeding electrons Los Alamos researchers believe they have solved a lingering mystery about how electrons within Earth's radiation belt can suddenly become energetic enough to kill orbiting satellites. July 25, 2013 Artist's rendering of mechanism within Van Allen radiation belts An artist's rendering of a mechanism within the Van Allen radiation belts that can accelerate electrons to satellite-killing

  12. Look-ahead driver feedback and powertrain management

    SciTech Connect (OSTI)

    Verma, Rajeev

    2014-12-31

    Commercial medium and heavy vehicles, though only a small portion of total vehicle population, play a significant role in energy consumption. In 2012, these vehicles accounted for about 5775.5 trillion btu of energy consumption and 408.8 million tons of CO2 emissions annually, which is a quarter of the total energy burden of highway transportation in the United States [1]. This number is expected to surpass passenger car fuel use within the next few decades. In the meantime, most commercial vehicle fleets are running at a very low profit margin. It is a well known fact that fuel economy can vary significantly between drivers, even when they operate the same vehicle on the same route. According to the US Environmental Protection Agency (EPA) and Natural Resource Canada (NRCan), there is up to 35% fuel economy difference between drivers within the same commercial fleet [2] [3], [4]. Similar results were obtained from a Field Operation Test conducted by Eaton Corporation [5]. During this test as much as 30% fuel economy difference was observed among pick-up-and-delivery drivers and 11% difference was observed among line-haul drivers. The driver variability can be attributed to the fact that different drivers react differently to driving conditions such as road grade, traffic, speed limits, etc. For instance, analysis of over 600k miles of naturalistic heavy duty truck driving data [5] indicates that an experienced driver anticipates a downhill and eases up on the throttle to save fuel while an inexperienced driver lacks this judgment.

  13. X- And y-axis driver for rotating microspheres

    DOE Patents [OSTI]

    Weinstein, Berthold W.

    1979-01-01

    Apparatus for precise control of the motion and position of microspheres for examination of their interior and/or exterior. The apparatus includes an x- and y-axis driver mechanism controlled, for example, by a minicomputer for selectively rotating microspheres retained between a pair of manipulator arms having flat, smooth end surfaces. The driver mechanism includes an apertured plate and ball arrangement which provided for coupled equal and opposite movement of the manipulator arms in two perpendicular directions.

  14. Fact #574: June 8, 2009 Vehicles per Licensed Driver Rising | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 4: June 8, 2009 Vehicles per Licensed Driver Rising Fact #574: June 8, 2009 Vehicles per Licensed Driver Rising The number of vehicles in operation per licensed driver has risen steadily since 1950. In 1985, for the first time, there was one vehicle for every licensed driver. Since 1985, the number of vehicles in operation has exceeded the number of licensed drivers reaching a level of 1.21 vehicles per licensed driver in 2007. Vehicles per Licensed Driver, 1950-2007 Line graph

  15. Analyzing Vehicle Fuel Saving Opportunities through Intelligent Driver Feedback

    SciTech Connect (OSTI)

    Gonder, J.; Earleywine, M.; Sparks, W.

    2012-06-01

    Driving style changes, e.g., improving driver efficiency and motivating driver behavior changes, could deliver significant petroleum savings. This project examines eliminating stop-and-go driving and unnecessary idling, and also adjusting acceleration rates and cruising speeds to ideal levels to quantify fuel savings. Such extreme adjustments can result in dramatic fuel savings of over 30%, but would in reality only be achievable through automated control of vehicles and traffic flow. In real-world driving, efficient driving behaviors could reduce fuel use by 20% on aggressively driven cycles and by 5-10% on more moderately driven trips. A literature survey was conducted of driver behavior influences, and pertinent factors from on-road experiments with different driving styles were observed. This effort highlighted important driver influences such as surrounding vehicle behavior, anxiety over trying to get somewhere quickly, and the power/torque available from the vehicle. Existing feedback approaches often deliver efficiency information and instruction. Three recommendations for maximizing fuel savings from potential drive cycle improvement are: (1) leveraging applications with enhanced incentives, (2) using an approach that is easy and widely deployable to motivate drivers, and (3) utilizing connected vehicle and automation technologies to achieve large and widespread efficiency improvements.

  16. Plans for a proton driver at Fermilab

    SciTech Connect (OSTI)

    Kephart, R.D.; /Fermilab

    2005-01-01

    , and will certainly have important implications for our understanding of cosmology and the evolution of the early Universe. The current Fermilab Program is an important part of the world-wide accelerator based effort to explore and understand the physics of neutrino oscillations. By early 2005, with both MINOS and MiniBooNE taking data, Fermilab will be able to answer some of the most pressing first-round questions raised by the discovery that neutrinos have mass. Fermilab's high-intensity neutrino beams are derived from 8- and 120-GeV proton beams. MiniBooNE is currently taking data using 8 GeV Protons from the Booster. The 120 GeV NuMI beam will start to operate in early 2005 using a 0.25 MW proton beam power from the Main Injector. Future neutrino programs will build on these existing facilities. New short and long baseline experiments have been proposed. There are proposals to increase the available number of protons at 8 and 120 GeV with the goal of addressing the full range of questions presented by neutrino oscillations. Key to that vision is a new intense proton source that usually is referred to as the Proton Driver.

  17. BEAM SIMULATIONS USING VIRTUAL DIAGNOSTICS FOR THE DRIVER LINAC

    SciTech Connect (OSTI)

    R. C. York; X. Wu; Q. Zhao

    2011-12-21

    End-to-end beam simulations for the driver linac have shown that the design meets the necessary performance requirements including having adequate transverse and longitudinal acceptances. However, to achieve reliable operational performance, the development of appropriate beam diagnostic systems and control room procedures are crucial. With limited R&D funding, beam simulations provide a cost effective tool to evaluate candidate beam diagnostic systems and to provide a critical basis for developing early commissioning and later operational activities. We propose to perform beam dynamic studies and engineering analyses to define the requisite diagnostic systems of the driver linac and through simulation to develop and test commissioning and operational procedures.

  18. TMACS test procedure TP009: Acromag driver. Revision 5

    SciTech Connect (OSTI)

    Bass, R.B.; Washburn, S.J.

    1994-09-01

    The TMACS Software Project Test Procedures translate the project`s acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure addresses the testing of the functionality of the TMACS Acromag driver software in conjunction with a new bridge for the Panalarm Annunciator system.

  19. U-226: Linux Kernel SFC Driver TCP MSS Option Handling Denial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6: Linux Kernel SFC Driver TCP MSS Option Handling Denial of Service Vulnerability U-226: Linux Kernel SFC Driver TCP MSS Option Handling Denial of Service Vulnerability August 2,...

  20. Fact #761: January 7, 2013 Smaller Share of Teenagers Have a Driver's License in 2010

    Broader source: Energy.gov [DOE]

    In the 1980's, more than half of all teenagers 15 to 19 years old had a driver's license. But that has changed. Since 1995, less than half of that age group has a driver's license. In 2010, the...

  1. Final Report on the Fuel Saving Effectiveness of Various Driver Feedback Approaches

    SciTech Connect (OSTI)

    Gonder, J.; Earleywine, M.; Sparks, W.

    2011-03-01

    This final report quantifies the fuel-savings opportunities from specific driving behavior changes, identifies factors that influence drivers' receptiveness to adopting fuel-saving behaviors, and assesses various driver feedback approaches.

  2. Commitment to Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Create a Sustainable Future » Commitment to Public Involvement Commitment to Public Involvement LANL is committed to our neighbors August 1, 2013 Lab Director McMillan talks with Lab historian Ellen McGhee during Lab tour Lab Director McMillan talks with Lab historian Ellen McGhee during Lab tour RELATED IMAGES http://farm4.staticflickr.com/3815/9442115459_390e5bc841_t.jpg Enlarge http://farm8.staticflickr.com/7111/7650961650_ed1571174f_t.jpg Enlarge

  3. Laser-seeded modulation instability in a proton driver plasma wakefield accelerator

    SciTech Connect (OSTI)

    Siemon, Carl; Khudik, Vladimir; Austin Yi, S.; Shvets, Gennady; Pukhov, Alexander

    2013-10-15

    A new method for initiating the modulation instability (MI) of a proton beam in a proton driver plasma wakefield accelerator using a short laser pulse preceding the beam is presented. A diffracting laser pulse is used to produce a plasma wave that provides a seeding modulation of the proton bunch with the period equal to that of the plasma wave. Using the envelope description of the proton beam, this method of seeding the MI is analytically compared with the earlier suggested seeding technique that involves an abrupt truncation of the proton bunch. The full kinetic simulation of a realistic proton bunch is used to validate the analytic results. It is further used to demonstrate that a plasma density ramp placed in the early stages of the laser-seeded MI leads to its stabilization, resulting in sustained accelerating electric fields (of order several hundred MV/m) over long propagation distances (∼100–1000 m)

  4. Heavy ion induction linac drivers for inertial confinement fusion

    SciTech Connect (OSTI)

    Lee, E.P.; Hovingh, J.

    1988-10-01

    Intense beams of high energy heavy ions (e.g., 10 GeV Hg) are an attractive option for an ICF driver because of their favorable energy deposition characteristics. The accelerator systems to produce the beams at the required power level are a development from existing technologies of the induction linac, rf linac/storage ring, and synchrotron. The high repetition rate of the accelerator systems, and the high efficiency which can be realized at high current make this approach especially suitable for commercial ICF. The present report gives a summary of the main features of the induction linac driver system, which is the approach now pursued in the USA. The main subsystems, consisting of injector, multiple beam accelerator at low and high energy, transport and pulse compression lines, and final focus are described. Scale relations are given for the current limits and other features of these subsystems. 17 refs., 1 fig., 1 tab.

  5. NEVADA NATIONAL SECURITY SITE (NNSS) DRIVERS ROUTE/SHIPMENT INFORMATION

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (NNSS) DRIVERS ROUTE/SHIPMENT INFORMATION (12/2014 Log No. 2014-229) NOTE: THIS FORM IS TWO (2) PAGES - YOU MUST COMPLETE BOTH PAGES NNSS SHIPMENT NUMBER: CARRIER NAME: TRACTOR NO.: TRAILER NO.: AT ORIGIN AT NNSS Main Gate NNSS OFFICE USE ONLY DEPARTURE DATE: ARRIVAL DATE: DESTINATION AREA: Area 5 DEPARTURE TIME: ARRIVAL TIME: NNSS DEPARTURE TIME: LOCATION: HELD OVER? No Yes REASON: ROUTE INFORMATION REVIEWED BY: ONSITE SHIPMENT (MAP NOT APPLICABLE) DROP YARD; LEAVE THIS FORM WITH SHIPPING

  6. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Involvement and Communication Committee Chair 1 : Liz Mattson 4 , Member Vice Chair 1 : Shannon Cram, Member Committee Members 2 : Shelley Cimon Paige Knight Alissa Cordner Liz Mattson Shannon Cram Ken Niles Rob Davis Ed Pacheco Tom Galioto Dan Serres Floyd Hodges Jean Vanni Unofficial Committee Members or Other Interested Parties 3 : Earl Fordham Gerry Pollet Susan Leckband 4 Steve Hudson 4 Facilitator: Cathy McCague 4 Agency & Technical Support: Kris Holmes 4 DOE-RL Randy Bradbury 4

  7. Fossil assests management: Making decisions on older plants

    SciTech Connect (OSTI)

    Douglas, J.

    1996-01-01

    Deregulation of the bulk power market is prompting many electric utilities to reexamine their older fossil generating units to see how they fit into the company`s overall operating strategy and whether they should be retired or modified to help the company become more competitive. EPRI`s Fossil Assets Management methodologies provide a formal value-analysis process for determining which investment and utilization options for fossil plants provide the greatest benfits at the corporate level. Three major types of asset management decisions are involved: how to deploy each unit in a utility`s fossil plant fleet, what investments should be made at specific plants, and how to modify operation and maintenance practices in view of present equipment condition. EPRI has also developed the Strategic Asset Management methodology which focuses on even border alternatives for allocating budgets and staff time across the utility. The FAM and SAM methodologies can be used together to analyze a full suite of asset management decisions, ranging from corporate-level reorganization to key equipment purchases at specific plants. This paper describes these strategies.

  8. Fundamental Drivers of the Cost and Price of Operating Reserves

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fundamental Drivers of the Cost and Price of Operating Reserves Marissa Hummon, Paul Denholm, Jennie Jorgenson, and David Palchak National Renewable Energy Laboratory Brendan Kirby Consultant Ookie Ma U.S. Department of Energy Technical Report NREL/TP-6A20-58491 July 2013 NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency & Renewable Energy Operated by the Alliance for Sustainable Energy, LLC This report is available at no cost from the National

  9. Unemployed Truck Driver Trains for New Career in Weatherization |

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy Maya Payne Smart Former Writer for Energy Empowers, EERE What does this mean for me? Workers across the country are being retrained for careers in the new clean energy economy. Tyrone Bailey had been out of work for 14 months when an unemployment office staffer told him about a home-weatherization training program offered by the state of New Jersey. The former truck driver and construction worker jumped at the opportunity to acquire new skills and began training January

  10. What Use Patterns Were Observed for PEV Drivers at Publicly Accessible AC Level 2 EVSE Sites?

    SciTech Connect (OSTI)

    Francfort, James Edward

    2015-12-01

    The EV Project deployed over 4,000 ACL2 EVSE for drivers to charge their plug-in electric vehicle (PEV) when away-from-home. The vast majority of these EVSE stations were installed to be available to all PEV drivers at publicly accessible locations. Some were also deployed for use at workplaces and fleets. This paper examines only the use patterns of PEV drivers using the EVSE intended to be publicly accessible.

  11. Drivers` activities and information needs in an automated highway system. Working paper, August 1995-May 1996

    SciTech Connect (OSTI)

    Levitan, L.; Bloomfield, J.

    1996-10-01

    In most visions of the AHS--including that of the National Automated Highway System Consortium--it has been assumed that when a vehicle was under automated control, the driver would be allowed to engage in any of a variety of activities not related to driving (e.g, working, reading, sleeping). The objective of the first study reported here--one of the noncommuter studies--was to determine what drivers do when traveling under automated control, and whether the age of and/gender or the driver and/or the intrastring gap have an influence on those activities. One the objectives of the commuter experiment--of relevance for this report--was to determine whether what drivers do when traveling under automated control changes as a function of experience with the AHS (i.e., across trials). As conceptualization of the AHS proceeds, the details of the interface between the driver and the in-vehicle system will become more important. One part of that interface will be information supplied by the AHS to the driver, perhaps about such things as traffic conditions ahead predicted trip time to the driver`s selected exit, and so on. To maximize the utility of that information, it is important to determine what it is that drivers would like to know when traveling under automated control. The objective of the third study reported here--the second of the five noncommuter experiments--was to provide a first investigation of that issue.

  12. Philips Light Sources & Electronics is Developing an Efficient, Smaller, Cost-Effective Family of LED Drivers

    Broader source: Energy.gov [DOE]

    With the help of DOE funding, Philips Light Sources & Electronics is developing a new family of LED drivers that are more efficient and cost-effective as well as smaller in size than currently available drivers. The new drivers are switch-mode power supplies that are similar to today's drivers, but with an improved design. In addition, they have a different topology—boost plus LLC—for wattages of 40W and above, but they retain the commonly used flyback topology at lower wattages.

  13. Aiming to Green NASCAR's Future: Q&A with Driver Leilani Munter...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Carbon Free Girl Leilani Mnter is not your usual NASCAR driver. An avid environmentalist, Mnter's goal is to spread an energy efficiency and green message to NASCAR's 75 ...

  14. UWB multi-burst transmit driver for averaging receivers

    DOE Patents [OSTI]

    Dallum, Gregory E

    2012-11-20

    A multi-burst transmitter for ultra-wideband (UWB) communication systems generates a sequence of precisely spaced RF bursts from a single trigger event. There are two oscillators in the transmitter circuit, a gated burst rate oscillator and a gated RF burst or RF power output oscillator. The burst rate oscillator produces a relatively low frequency, i.e., MHz, square wave output for a selected transmit cycle, and drives the RF burst oscillator, which produces RF bursts of much higher frequency, i.e., GHz, during the transmit cycle. The frequency of the burst rate oscillator sets the spacing of the RF burst packets. The first oscillator output passes through a bias driver to the second oscillator. The bias driver conditions, e.g., level shifts, the signal from the first oscillator for input into the second oscillator, and also controls the length of each RF burst. A trigger pulse actuates a timing circuit, formed of a flip-flop and associated reset time delay circuit, that controls the operation of the first oscillator, i.e., how long it oscillates (which defines the transmit cycle).

  15. Study of CSR Effects in the Jefferson Laboratory FEL Driver

    SciTech Connect (OSTI)

    Hall, C. C.; Biedron, S.; Burleson, Theodore A.; Milton, Stephen V.; Morin, Auralee L.; Benson, Stephen V.; Douglas, David R.; Evtushenko, Pavel E.; Hannon, Fay E.; Li, Rui; Tennant, Christopher D.; Zhang, Shukui; Carlsten, Bruce E.; Lewellen, John W.

    2013-08-01

    In a recent experiment conducted on the Jefferson Laboratory IR FEL driver the effects of Coherent Synchrotron Radiation (CSR) on beam quality were studied. The primary goal of this work was to explore CSR output and effect on the beam with variation of the bunch compression in the IR chicane. This experiment also provides a valuable opportunity to benchmark existing CSR models in a system that may not be fully represented by a 1-D CSR model. Here we present results from this experiment and compare to initial simulations of CSR in the magnetic compression chicane of the machine. Finally, we touch upon the possibility for CSR induced microbunching gain in the magnetic compression chicane, and show that parameters in the machine are such that it should be thoroughly damped.

  16. Low impedance z-pinch drivers without post-hole convolute current adders.

    SciTech Connect (OSTI)

    Savage, Mark Edward; Seidel, David Bruce; Mendel, Clifford Will, Jr.

    2009-09-01

    Present-day pulsed-power systems operating in the terawatt regime typically use post-hole convolute current adders to operate at sufficiently low impedance. These adders necessarily involve magnetic nulls that connect the positive and negative electrodes. The resultant loss of magnetic insulation results in electron losses in the vicinity of the nulls that can severely limit the efficiency of the delivery of the system's energy to a load. In this report, we describe an alternate transformer-based approach to obtaining low impedance. The transformer consists of coils whose windings are in parallel rather than in series, and does not suffer from the presence of magnetic nulls. By varying the pitch of the coils windings, the current multiplication ratio can be varied, leading to a more versatile driver. The coupling efficiency of the transformer, its behavior in the presence of electron flow, and its mechanical strength are issues that need to be addressed to evaluate the potential of transformer-based current multiplication as a viable alternative to conventional current adder technology.

  17. Public Involvement and Communications Committee:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    purposes only 09.08.15 Excerpt from the HAB Process Manual January 2012 Public Involvement and Communications Committee: Develops Board Advice for the TPA agencies on the...

  18. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    September 3, 2014 Public Involvement Opportunities * Review of PI materials and agency websites, listservs (use of and purpose of notifications). * CD process - approach to PI...

  19. Lumileds Develops High-Voltage LED Light Engine with Integrated Driver

    Broader source: Energy.gov [DOE]

    With the help of DOE funding, Lumileds has developed a high-voltage LED light engine with an integrated driver, achieving an efficacy greater than 128 lm/W at a luminous flux greater than 4,100 lm...

  20. Vehicle Technologies Office Merit Review 2014: Look-Ahead Driver Feedback and Powertrain Management

    Broader source: Energy.gov [DOE]

    Presentation given by Eaton at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about look-ahead driver feedback and...

  1. Science Driver Requirements for Seeded Soft X-ray Free Electron...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Driver Requirements for Seeded Soft X-ray Free Electron Lasers Wednesday, December 2, 2015 - 2:00pm SLAC, Redtail Hawk Conference Room 108A Speaker: Fulvio Parmigiani,...

  2. Vehicle Technologies Office Merit Review 2015: Gate Driver Optimization for WBG Applications

    Broader source: Energy.gov [DOE]

    Presentation given by Oak Ridge National Laboratory at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about gate driver...

  3. Science Drivers of Particle Physics | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science Drivers of Particle Physics High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  4. Fact #845 November 3, 2014 From 1970 to 2013 the Share of Older...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Share of Older Vehicles in Operation has Increased Fact 845 November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in Operation has Increased In 1970 only 3% of ...

  5. Large Synoptic Survey Telescope: From Science Drivers to Reference Design

    SciTech Connect (OSTI)

    Ivezic, Z.; Axelrod, T.; Brandt, W.N.; Burke, D.L.; Claver, C.F.; Connolly, A.; Cook, K.H.; Gee, P.; Gilmore, D.K.; Jacoby, S.H.; Jones, R.L.; Kahn, S.M.; Kantor, J.P.; Krabbendam, V.; Lupton, R.H.; Monet, D.G.; Pinto, P.A.; Saha, A.; Schalk, T.L.; Schneider, D.P.; Strauss, Michael A.; /Washington U., Seattle, Astron. Dept. /LSST Corp. /Penn State U., Astron. Astrophys. /KIPAC, Menlo Park /NOAO, Tucson /LLNL, Livermore /UC, Davis /Princeton U., Astrophys. Sci. Dept. /Naval Observ., Flagstaff /Arizona U., Astron. Dept. - Steward Observ. /UC, Santa Cruz /Harvard U. /Johns Hopkins U. /Illinois U., Urbana

    2011-10-14

    LSST science drivers led to these choices of system parameters.

  6. DOE - NNSA/NFO -- EM Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Involvement NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Click to subscribe to NNSS News Public Involvement Public Involvement Outreach Photo An integral ...

  7. Effect of driver impedance on dense plasma focus Z-pinch neutron yield

    SciTech Connect (OSTI)

    Sears, Jason E-mail: schmidt36@llnl.gov; Link, Anthony E-mail: schmidt36@llnl.gov; Schmidt, Andrea E-mail: schmidt36@llnl.gov; Welch, Dale

    2014-12-15

    The Z-pinch phase of a dense plasma focus (DPF) heats the plasma by rapid compression and accelerates ions across its intense electric fields, producing neutrons through both thermonuclear and beam-target fusion. Driver characteristics have empirically been shown to affect performance, as measured by neutron yield per unit of stored energy. We are exploring the effect of driver characteristics on DPF performance using particle-in-cell (PIC) simulations of a kJ scale DPF. In this work, our PIC simulations are fluid for the run-down phase and transition to fully kinetic for the pinch phase, capturing kinetic instabilities, anomalous resistivity, and beam formation during the pinch. The anode-cathode boundary is driven by a circuit model of the capacitive driver, including system inductance, the load of the railgap switches, the guard resistors, and the coaxial transmission line parameters. It is known that the driver impedance plays an important role in the neutron yield: first, it sets the peak current achieved at pinch time; and second, it affects how much current continues to flow through the pinch when the pinch inductance and resistance suddenly increase. Here we show from fully kinetic simulations how total neutron yield depends on the impedance of the driver and the distributed parameters of the transmission circuit. Direct comparisons between the experiment and simulations enhance our understanding of these plasmas and provide predictive design capability for neutron source applications.

  8. Grid Parity for Residential Photovoltaics in the United States: Key Drivers and Sensitivities; Preprint

    SciTech Connect (OSTI)

    Ong, S.; Denholm, P.; Clark, N.

    2012-08-01

    In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that electricity price rather than technical parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  9. Drivers of U.S. Household Energy Consumption, 1980-2009

    U.S. Energy Information Administration (EIA) Indexed Site

    Drivers of U.S. Household Energy Consumption, 1980-2009 February 2015 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 U.S. Energy Information Administration | Drivers of U.S. Household Energy Consumption, 1980-2009 i This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any

  10. Summer gasoline price forecast slightly higher, but drivers still pay less than last year

    U.S. Energy Information Administration (EIA) Indexed Site

    Summer gasoline price forecast slightly higher, but drivers still pay less than last year Rising crude oil prices are likely to be passed on to consumers at the pump, but U.S. drivers are still expected to pay the lowest summer gasoline prices since 2004, and for all of 2016 the average household will spend $900 less on gasoline than it did two years ago." In its new monthly forecast, the U.S. Energy Information Administration said the retail price for regular grade gasoline will average

  11. HOW YOU CAN BE INVOLVED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HOW YOU CAN BE INVOLVED www.youtube.com/hanfordsite www.twitter.com/hanfordsite www.facebook.com/hanfordsite The Hanford Site sits on 586-square-miles of shrub-steppe desert in southeastern Washington state. The site was created in 1943 as part of the Manhattan Project to produce plutonium for nuclear weapons. Between 1943 and 1963, nine nuclear reactors were built along the banks of the Columbia River. By 1988, all nine reactors were shut down. The weapons material production mission ended in

  12. Evaluation of Negative-Ion-Beam Driver Concepts for Heavy Ion Fusion

    SciTech Connect (OSTI)

    Grisham, Larry R.

    2003-03-15

    The feasibility of producing and using atomically neutral heavy ion beams produced from negative ions as drivers for an inertial confinement fusion reactor is evaluated. Bromine and iodine appear to be the most attractive elements for the driver beams. Fluorine and chlorine appear to be the most appropriate feedstocks for initial tests of extractable negative-ion current densities. With regard to ion sources, photodetachment neutralizers, and vacuum requirements for accelerators and beam transport, this approach appears feasible within existing technology, and the vacuum requirements are essentially identical to those for positive-ion drivers except in the target chamber. The principal constraint is that this approach requires harder vacuums in the target chamber than do space-charge-neutralized positive-ion drivers. With realistic (but perhaps pessimistic) estimates of the total ionization cross section, limiting the ionization of a neutral beam to <5% while traversing a 3-m path would require a chamber pressure of no more than 1.3 x 10{sup -5} torr. However, it appears that substantial improvements in the beam spot size on target might be achieved at pressures a factor of 10 or more higher than this. Alternatively, even at still higher chamber pressures that would strongly ionize atomically neutral beams, the negative-ion approach may still have significant appeal, since it precludes the possibly challenging problem of electron contamination of a positive-ion beam during acceleration, drift compression, and focusing.

  13. Evaluation of Negative-Ion-Beam Driver Concepts for Heavy Ion Fusion

    SciTech Connect (OSTI)

    Larry R. Grisham

    2002-01-14

    We evaluate the feasibility of producing and using atomically neutral heavy ion beams produced from negative ions as drivers for an inertial confinement fusion reactor. Bromine and iodine appear to be the most attractive elements for the driver beams. Fluorine and chlorine appear to be the most appropriate feedstocks for initial tests of extractable negative ion current densities. With regards to ion sources, photodetachment neutralizers, and vacuum requirements for accelerators and beam transport, this approach appears feasible within existing technology, and the vacuum requirements are essentially identical to those for positive ion drivers except in the target chamber. The principal constraint is that this approach requires harder vacuums in the target chamber than do space-charge-neutralized positive ion drivers. With realistic (but perhaps pessimistic) estimates of the total ionization cross section, limiting the ionization of a neutral beam to less than 5% while traversing a four -meter path would require a chamber pressure of no more than 5 x 10{sup -5} torr. Alternatively, even at chamber pressures that are too high to allow propagation of atomically neutral beams, the negative ion approach may still have appeal, since it precludes the possibly serious problem of electron contamination of a positive ion beam during acceleration, drift compression, and focusing.

  14. Refueling Behavior of Flexible Fuel Vehicle Drivers in the Federal Fleet

    SciTech Connect (OSTI)

    Daley, R.; Nangle, J.; Boeckman, G.; Miller, M.

    2014-05-01

    Federal fleets are a frequent subject of legislative and executive efforts to lead a national transition to alternative fuels and advanced vehicle technologies. Section 701 of the Energy Policy Act of 2005 requires that all dual-fueled alternative fuel vehicles in the federal fleet be operated on alternative fuel 100% of the time when they have access to it. However, in Fiscal Year (FY) 2012, drivers of federal flex fuel vehicles (FFV) leased through the General Services Administration refueled with E85 24% of the time when it was available--falling well short of the mandate. The U.S. Department of Energy's National Renewable Energy Laboratory completed a 2-year Laboratory Directed Research and Development project to identify the factors that influence the refueling behavior of federal FFV drivers. The project began with two primary hypotheses. First, information scarcity increases the tendency to miss opportunities to purchase E85. Second, even with perfect information, there are limits to how far drivers will go out of their way to purchase E85. This paper discusses the results of the project, which included a June 2012 survey of federal fleet drivers and an empirical analysis of actual refueling behavior from FY 2009 to 2012. This research will aid in the design and implementation of intervention programs aimed at increasing alternative fuel use and reducing petroleum consumption.

  15. Current status of the superconducting RF linac driver for the JAERI Free Electron Laser Facility

    SciTech Connect (OSTI)

    Minehara, E.J.; Sugimoto, M.; Sawamura, M.

    1995-12-31

    The commissioning of the superconducting rf linac driver for the JAERI free electron laser facility has been successfully performed at 10{approx}20 MeV before the end of the 1994 Japanese fiscal year. The performance obtained during the commissioning and current status of the JAERI FEL program at Tokai will be reported in detail.

  16. What kind of charging infrastructure do Chevrolet Volts Drivers in The EV Project use?

    SciTech Connect (OSTI)

    John Smart

    2013-09-01

    This report summarizes key conclusions from analysis of data collected from Chevrolet Volts participating in The EV Project. Topics include how much Volt drivers charge at level 1 vs. level 2 rates and how much they charge at home vs. away from home.

  17. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8, 2012 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING February 8, 2012 Richland, WA Topics in this Meeting Summary Welcome and Introductions .......................................................................................................................... 1 Update on Timely Public Involvement Topics ............................................................................................. 1 Public Involvement for Technical

  18. DECONTAMINATION DRESSDOWN AT A TRANSPORTATION ACCIDENT INVOLVING...

    Office of Environmental Management (EM)

    Video User' s Guide DECONTAMINATION DRESSDOWN AT A TRANSPORTATION ACCIDENT INVOLVING ... related to emergency response to a transportation accident involving radioactive material. ...

  19. Community Involvement | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Involvement Community Involvement Y-12 is committed to keeping the community informed in areas of operations, environmental concerns, safety and emergency preparedness. To...

  20. EXTENDING THE USEFUL LIFE OF OLDER MASS SPECTROMETERS

    SciTech Connect (OSTI)

    Johnson, S.; Cordaro, J.; Holland, M.; Jones, V.

    2010-06-17

    Thermal ionization and gas mass spectrometers are widely used across the Department of Energy (DOE) Complex and contractor laboratories. These instruments support critical missions, where high reliability and low measurement uncertainty are essential. A growing number of these mass spectrometers are significantly older than their original design life. The reality is that manufacturers have declared many of the instrument models obsolete, with direct replacement parts and service no longer available. Some of these obsolete models do not have a next generation, commercially available replacement. Today's budget conscious economy demands for the use of creative funds management. Therefore, the ability to refurbish (or upgrade) these valuable analytical tools and extending their useful life is a cost effective option. The Savannah River Site (SRS) has the proven expertise to breathe new life into older mass spectrometers, at a significant cost savings compared to the purchase and installation of new instruments. A twenty-seven year old Finnigan MAT-261{trademark} Thermal Ionization Mass Spectrometer (TIMS), located at the SRS F/H Area Production Support Laboratory, has been successfully refurbished. Engineers from the Savannah River National Laboratory (SRNL) fabricated and installed the new electronics. These engineers also provide continued instrument maintenance services. With electronic component drawings being DOE Property, other DOE Complex laboratories have the option to extend the life of their aged Mass Spectrometers.

  1. Advanced beam-dynamics simulation tools for the RIA driver linac,Part I: Low energy beam transport and radiofrequency quadrupole

    SciTech Connect (OSTI)

    Wangler, Thomas P.; Crandall, Kenneth R.; Garnett, Robert W.; Gorelov, Dmitry; Ostroumov, Petr; Qiang, Ji; Ryne, Robert; York, Richard

    2003-08-26

    Advanced Beam-Dynamics Simulation Tools for the RIA Driver Linac; Low Energy Beam Transport and Radiofrequency Quadrupole.

  2. Fact #845 November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Operation has Increased | Department of Energy 5 November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in Operation has Increased Fact #845 November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in Operation has Increased In 1970 only 3% of the cars in operation were 15 years old or older. With cars lasting much longer today, 19% of cars in operation in 2013 were that same category. The 15 years old and older category cannot be separated into individual years, thus the

  3. Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield.

    SciTech Connect (OSTI)

    Sharpe, Robin Arthur; Kingsep, Alexander S. (Kurchatov Institute, Moscow, Russia); Smith, David Lewis; Olson, Craig Lee; Ottinger, Paul F. (Naval Research Laboratory, Washington, DC); Schumer, Joseph Wade (Naval Research Laboratory, Washington, DC); Welch, Dale Robert (Voss Scientific, Albuquerque, NM); Kim, Alexander (High Currents Institute, Tomsk, Russia); Kulcinski, Gerald L. (University of Wisconsin, Madison, WI); Kammer, Daniel C. (University of Wisconsin, Madison, WI); Rose, David Vincent (Voss Scientific, Albuquerque, NM); Nedoseev, Sergei L. (Kurchatov Institute, Moscow, Russia); Pointon, Timothy David; Smirnov, Valentin P.; Turgeon, Matthew C.; Kalinin, Yuri G. (Kurchatov Institute, Moscow, Russia); Bruner, Nichelle "Nicki" (Voss Scientific, Albuquerque, NM); Barkey, Mark E. (University of Alabama, Tuscaloosa, AL); Guthrie, Michael (University of Wisconsin, Madison, WI); Thoma, Carsten (Voss Scientific, Albuquerque, NM); Genoni, Tom C. (Voss Scientific, Albuquerque, NM); Langston, William L.; Fowler, William E.; Mazarakis, Michael Gerrassimos

    2007-01-01

    Z-Pinch Inertial Fusion Energy (Z-IFE) complements and extends the single-shot z-pinch fusion program on Z to a repetitive, high-yield, power plant scenario that can be used for the production of electricity, transmutation of nuclear waste, and hydrogen production, all with no CO{sub 2} production and no long-lived radioactive nuclear waste. The Z-IFE concept uses a Linear Transformer Driver (LTD) accelerator, and a Recyclable Transmission Line (RTL) to connect the LTD driver to a high-yield fusion target inside a thick-liquid-wall power plant chamber. Results of RTL and LTD research are reported here, that include: (1) The key physics issues for RTLs involve the power flow at the high linear current densities that occur near the target (up to 5 MA/cm). These issues include surface heating, melting, ablation, plasma formation, electron flow, magnetic insulation, conductivity changes, magnetic field diffusion changes, possible ion flow, and RTL mass motion. These issues are studied theoretically, computationally (with the ALEGRA and LSP codes), and will work at 5 MA/cm or higher, with anode-cathode gaps as small as 2 mm. (2) An RTL misalignment sensitivity study has been performed using a 3D circuit model. Results show very small load current variations for significant RTL misalignments. (3) The key structural issues for RTLs involve optimizing the RTL strength (varying shape, ribs, etc.) while minimizing the RTL mass. Optimization studies show RTL mass reductions by factors of three or more. (4) Fabrication and pressure testing of Z-PoP (Proof-of-Principle) size RTLs are successfully reported here. (5) Modeling of the effect of initial RTL imperfections on the buckling pressure has been performed. Results show that the curved RTL offers a much greater buckling pressure as well as less sensitivity to imperfections than three other RTL designs. (6) Repetitive operation of a 0.5 MA, 100 kV, 100 ns, LTD cavity with gas purging between shots and automated operation is

  4. Ferroelectric opening switches for large-scale pulsed power drivers.

    SciTech Connect (OSTI)

    Brennecka, Geoffrey L.; Rudys, Joseph Matthew; Reed, Kim Warren; Pena, Gary Edward; Tuttle, Bruce Andrew; Glover, Steven Frank

    2009-11-01

    Fast electrical energy storage or Voltage-Driven Technology (VDT) has dominated fast, high-voltage pulsed power systems for the past six decades. Fast magnetic energy storage or Current-Driven Technology (CDT) is characterized by 10,000 X higher energy density than VDT and has a great number of other substantial advantages, but it has all but been neglected for all of these decades. The uniform explanation for neglect of CDT technology is invariably that the industry has never been able to make an effective opening switch, which is essential for the use of CDT. Most approaches to opening switches have involved plasma of one sort or another. On a large scale, gaseous plasmas have been used as a conductor to bridge the switch electrodes that provides an opening function when the current wave front propagates through to the output end of the plasma and fully magnetizes the plasma - this is called a Plasma Opening Switch (POS). Opening can be triggered in a POS using a magnetic field to push the plasma out of the A-K gap - this is called a Magnetically Controlled Plasma Opening Switch (MCPOS). On a small scale, depletion of electron plasmas in semiconductor devices is used to affect opening switch behavior, but these devices are relatively low voltage and low current compared to the hundreds of kilo-volts and tens of kilo-amperes of interest to pulsed power. This work is an investigation into an entirely new approach to opening switch technology that utilizes new materials in new ways. The new materials are Ferroelectrics and using them as an opening switch is a stark contrast to their traditional applications in optics and transducer applications. Emphasis is on use of high performance ferroelectrics with the objective of developing an opening switch that would be suitable for large scale pulsed power applications. Over the course of exploring this new ground, we have discovered new behaviors and properties of these materials that were here to fore unknown. Some of

  5. EMERGENCY RESPONSE TO A TRANSPORTATION ACCIDENT INVOLVING RADIOACTIVE...

    Office of Environmental Management (EM)

    ransportation ransportation ransportation ransportation Accident Involving Radioactive Material Accident Involving Radioactive Material Accident Involving Radioactive ...

  6. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-01-01

    Hybrid electric vehicles, plug-in hybrid electric vehicles, and battery electric vehicles offer the potential to reduce both oil imports and greenhouse gases, as well as to offer a financial benefit to the driver. However, assessing these potential benefits is complicated by several factors, including the driving habits of the operator. We focus on driver aggression, i.e., the level of acceleration and velocity characteristic of travel, to (1) assess its variation within large, real-world drive datasets, (2) quantify its effect on both vehicle efficiency and economics for multiple vehicle types, (3) compare these results to those of standard drive cycles commonly used in the industry, and (4) create a representative drive cycle for future analyses where standard drive cycles are lacking.

  7. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles: Preprint

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-03-01

    Hybrid electric vehicles, plug-in hybrid electric vehicles, and battery electric vehicles offer the potential to reduce both oil imports and greenhouse gases, as well as to offer a financial benefit to the driver. However, assessing these potential benefits is complicated by several factors, including the driving habits of the operator. We focus on driver aggression, i.e., the level of acceleration and velocity characteristic of travel, to (1) assess its variation within large, real-world drive datasets, (2) quantify its effect on both vehicle efficiency and economics for multiple vehicle types, (3) compare these results to those of standard drive cycles commonly used in the industry, and (4) create a representative drive cycle for future analyses where standard drive cycles are lacking.

  8. Drivers and barriers to e-invoicing adoption in Greek large scale manufacturing industries

    SciTech Connect (OSTI)

    Marinagi, Catherine E-mail: ptrivel@yahoo.com Trivellas, Panagiotis E-mail: ptrivel@yahoo.com Reklitis, Panagiotis E-mail: ptrivel@yahoo.com; Skourlas, Christos

    2015-02-09

    This paper attempts to investigate the drivers and barriers that large-scale Greek manufacturing industries experience in adopting electronic invoices (e-invoices), based on three case studies with organizations having international presence in many countries. The study focuses on the drivers that may affect the increase of the adoption and use of e-invoicing, including the customers demand for e-invoices, and sufficient know-how and adoption of e-invoicing in organizations. In addition, the study reveals important barriers that prevent the expansion of e-invoicing, such as suppliers’ reluctance to implement e-invoicing, and IT infrastructures incompatibilities. Other issues examined by this study include the observed benefits from e-invoicing implementation, and the financial priorities of the organizations assumed to be supported by e-invoicing.

  9. Managing the Drivers of Air Flow and Water Vapor Transport in Existing Single-Family Homes

    SciTech Connect (OSTI)

    Cummings, James; Withers, Charles; Martin, Eric; Moyer, Neil

    2012-10-01

    This report is a revision of an earlier report titled: Measure Guideline: Managing the Drivers of Air Flow and Water Vapor Transport in Existing Single-Family Homes. Revisions include: Information in the text box on page 1 was revised to reflect the most accurate information regarding classifications as referenced in the 2012 International Residential Code. “Measure Guideline” was dropped from the title of the report. An addition was made to the reference list.

  10. Managing the Drivers of Air Flow and Water Vapor Transport in Existing Single Family Homes (Revised)

    SciTech Connect (OSTI)

    Cummings, J.; Withers, C.; Martin, E.; Moyer, N.

    2012-10-01

    This document focuses on managing the driving forces which move air and moisture across the building envelope. While other previously published Measure Guidelines focus on elimination of air pathways, the ultimate goal of this Measure Guideline is to manage drivers which cause air flow and water vapor transport across the building envelope (and also within the home), control air infiltration, keep relative humidity (RH) within acceptable limits, avoid combustion safety problems, improve occupant comfort, and reduce house energy use.

  11. Session 4: "Short-Term Energy Prices - What Drivers Matter Most?"

    U.S. Energy Information Administration (EIA) Indexed Site

    4: "Short-Term Energy Prices - What Drivers Matter Most?" Speakers: Howard K. Gruenspecht, EIA David M. Arseneau, Federal Reserve Board Guy F. Caruso, Center for Strategic and International Studies Christopher Ellsworth, Federal Energy Regulatory Commission Edward L. Morse, Credit Suisse Securities [Note: Recorders did not pick up introduction of panel (see biographies for details on the panelists) or introduction of session.] Howard: And this presentation could not be more timely,

  12. Design of a new main injector cavity for the Fermilab Proton Driver era

    SciTech Connect (OSTI)

    Wu, V.; Chen, A.; Qian, Z.; Wildman, D.W.; /Fermilab

    2005-05-01

    In the design report of the Fermilab Proton Driver [1], the Main Injector (MI) needs to be upgraded to a 2 MW machine. For the Main Injector radiofrequency (rf) upgrade, R&D efforts are launched to design and build a new rf system. This paper presents the new cavity design study for the rf system. The cavity is simulated with the design code Mafia [2].

  13. Creating a Well-focused Laser-accelerated Proton Beam as a Driver for

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proton Fast Ignition | U.S. DOE Office of Science (SC) Creating a Well-focused Laser-accelerated Proton Beam as a Driver for Proton Fast Ignition Fusion Energy Sciences (FES) FES Home About Research Facilities Science Highlights Benefits of FES Funding Opportunities Fusion Energy Sciences Advisory Committee (FESAC) Community Resources Contact Information Fusion Energy Sciences U.S. Department of Energy SC-24/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301)

  14. Reliable, high repetition rate thyratron grid driver used with a magnetic modulator

    SciTech Connect (OSTI)

    Hill, J.V.; Ball, D.G.; Garrett, D.N.

    1991-06-14

    The Atomic Vapor Laser Isotope Separation (AVLIS) Program at Lawrence Livermore National Laboratory uses a magnetic modulator switched by a high voltage thyratron to drive a gas discharge laser. The thyratron trigger source must provide an extremely reliable, low jitter, high- rep-rate grid pulse. This paper describes a thyratron grid driver which delivers a 1.2 kV, 80 ns rise time grid pulse into a 50 ohm load at up to 4.5 kHz repetition rate and has demonstrated approximately 10,000 hours MTBF. Since the thyratron is used with a magnetic compression circuit having a delay time of 1.4 ms this grid driver incorporates a jitter compensation circuit to adjust the trigger timing of the thyratron to provide overall modulator/laser jitter of less than {plus minus} 2 ns. The specific grid driver requirements will be discussed followed by a description of the circuit design and theory of operation. Construction comments will be followed by performance data (for a specific thyratron and magnetic compression circuit), including pulse shape, jitter, and lifetime. 1 ref., 10 figs.

  15. Survey of Laser Markets Relevant to Inertial Fusion Energy Drivers, information for National Research Council

    SciTech Connect (OSTI)

    Bayramian, A J; Deri, R J; Erlandson, A C

    2011-02-24

    Development of a new technology for commercial application can be significantly accelerated by leveraging related technologies used in other markets. Synergies across multiple application domains attract research and development (R and D) talent - widening the innovation pipeline - and increases the market demand in common components and subsystems to provide performance improvements and cost reductions. For these reasons, driver development plans for inertial fusion energy (IFE) should consider the non-fusion technology base that can be lveraged for application to IFE. At this time, two laser driver technologies are being proposed for IFE: solid-state lasers (SSLs) and KrF gas (excimer) lasers. This document provides a brief survey of organizations actively engaged in these technologies. This is intended to facilitate comparison of the opportunities for leveraging the larger technical community for IFE laser driver development. They have included tables that summarize the commercial organizations selling solid-state and KrF lasers, and a brief summary of organizations actively engaged in R and D on these technologies.

  16. HESFIRE: a global fire model to explore the role of anthropogenic and weather drivers

    SciTech Connect (OSTI)

    Le Page, Yannick LB; Morton, Douglas; Bond-Lamberty, Benjamin; Pereira, Jose M.; Hurtt, George C.

    2015-02-13

    Vegetation fires are a major driver of ecosystem dynamics and greenhouse gas emissions. Anticipating potential changes in fire activity and their impacts relies first on a realistic model of fire activity (e.g., fire incidence and interannual variability) and second on a model accounting for fire impacts (e.g., mortality and emissions). In this paper, we focus on our understanding of fire activity and describe a new fire model, HESFIRE (Human–Earth System FIRE), which integrates the influence of weather, vegetation characteristics, and human activities on fires in a stand-alone framework. It was developed with a particular emphasis on allowing fires to spread over consecutive days given their major contribution to burned areas in many ecosystems. A subset of the model parameters was calibrated through an optimization procedure using observation data to enhance our knowledge of regional drivers of fire activity and improve the performance of the model on a global scale. Modeled fire activity showed reasonable agreement with observations of burned area, fire seasonality, and interannual variability in many regions, including for spatial and temporal domains not included in the optimization procedure. Significant discrepancies are investigated, most notably regarding fires in boreal regions and in xeric ecosystems and also fire size distribution. The sensitivity of fire activity to model parameters is analyzed to explore the dominance of specific drivers across regions and ecosystems. The characteristics of HESFIRE and the outcome of its evaluation provide insights into the influence of anthropogenic activities and weather, and their interactions, on fire activity.

  17. Accounting for the Variation of Driver Aggression in the Simulation of Conventional and Advanced Vehicles (Presentation)

    SciTech Connect (OSTI)

    Neubauer, J.; Wood, E.

    2013-05-01

    This presentation discusses a method of accounting for realistic levels of driver aggression to higher-level vehicle studies, including the impact of variation in real-world driving characteristics (acceleration and speed) on vehicle energy consumption and different powertrains (e.g., conventionally powered vehicles versus electrified drive vehicles [xEVs]). Aggression variation between drivers can increase fuel consumption by more than 50% or decrease it by more than 20% from average. The normalized fuel consumption deviation from average as a function of population percentile was found to be largely insensitive to powertrain. However, the traits of ideal driving behavior are a function of powertrain. In conventional vehicles, kinetic losses dominate rolling resistance and aerodynamic losses. In xEVs with regenerative braking, rolling resistance and aerodynamic losses dominate. The relation of fuel consumption predicted from real-world drive data to that predicted by the industry-standard HWFET, UDDS, LA92, and US06 drive cycles was not consistent across powertrains, and varied broadly from the mean, median, and mode of real-world driving. A drive cycle synthesized by NREL's DRIVE tool accurately and consistently reproduces average real-world for multiple powertrains within 1%, and can be used to calculate the fuel consumption effects of varying levels of driver aggression.

  18. Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01

    Grid parity--or break-even cost--for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this report, we analyze PV break-even costs for U.S. residential customers. We evaluate some key drivers of grid parity both regionally and over time. We also examine the impact of moving from flat to time-of-use (TOU) rates, and we evaluate individual components of the break-even cost, including effect of rate structure and various incentives. Finally, we examine how PV markets might evolve on a regional basis considering the sensitivity of the break-even cost to four major drivers: technical performance, financing parameters, electricity prices and rates, and policies. We find that local incentives rather than ?technical? parameters are in general the key drivers of the break-even cost of PV. Additionally, this analysis provides insight about the potential viability of PV markets.

  19. Where do Chevrolet Volt drivers in The EV Project charge when they have the opportunity to charge at work?

    SciTech Connect (OSTI)

    John Smart; Don Scoffield

    2014-03-01

    This paper investigates where Chevy Volt drivers in the EV Project charge when they have the opportunity to charge at work. Do they charge at home, work, or some other location.

  20. Where do Nissan Leaf drivers in The EV Project charge when they have the opportunity to charge at work?

    SciTech Connect (OSTI)

    John Smart; Don Scoffield

    2014-03-01

    This paper invesigates where Nissan Leaf drivers in the EV Project charge when they have the opportunity to charge at work. Do they charge at work, home, or some other location?

  1. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3, 2011 FINAL WEBINAR SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING October 3, 2011 Topics in this Meeting Summary Welcome, introductions, and webinar overview .......................................................................................... 1 Introduction to the preliminary draft Hanford Public Involvement Plan ..................................................... 2 Results of the Heart of America Northwest Public Involvement Survey

  2. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11, 2011 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING October 11, 2011 Richland, WA Topics in this Meeting Summary Welcome and Introductions ............................................................................................................ 1 Draft Advice - Draft Hanford Public Involvement Plan ................................................................ 1 Public Meetings - Draft Hanford Public Involvement Plan

  3. HESFIRE: a global fire model to explore the role of anthropogenic and weather drivers

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Le Page, Yannick LB; Morton, Douglas; Bond-Lamberty, Benjamin; Pereira, Jose M.; Hurtt, George C.

    2015-02-13

    Vegetation fires are a major driver of ecosystem dynamics and greenhouse gas emissions. Anticipating potential changes in fire activity and their impacts relies first on a realistic model of fire activity (e.g., fire incidence and interannual variability) and second on a model accounting for fire impacts (e.g., mortality and emissions). In this paper, we focus on our understanding of fire activity and describe a new fire model, HESFIRE (Human–Earth System FIRE), which integrates the influence of weather, vegetation characteristics, and human activities on fires in a stand-alone framework. It was developed with a particular emphasis on allowing fires to spreadmore » over consecutive days given their major contribution to burned areas in many ecosystems. A subset of the model parameters was calibrated through an optimization procedure using observation data to enhance our knowledge of regional drivers of fire activity and improve the performance of the model on a global scale. Modeled fire activity showed reasonable agreement with observations of burned area, fire seasonality, and interannual variability in many regions, including for spatial and temporal domains not included in the optimization procedure. Significant discrepancies are investigated, most notably regarding fires in boreal regions and in xeric ecosystems and also fire size distribution. The sensitivity of fire activity to model parameters is analyzed to explore the dominance of specific drivers across regions and ecosystems. The characteristics of HESFIRE and the outcome of its evaluation provide insights into the influence of anthropogenic activities and weather, and their interactions, on fire activity.« less

  4. Battery Electric Vehicles: Range Optimization and Diversification for the U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong

    2012-01-01

    Properly selecting the driving range is critical for accurately predicting the market acceptance and the resulting social benefits of BEVs. Analysis of transportation technology transition could be biased against battery electric vehicles (BEV) and mislead policy making, if BEVs are not represented with optimal ranges. This study proposes a coherent method to optimize the BEV driving range by minimizing the range-related cost, which is formulated as a function of range, battery cost, energy prices, charging frequency, access to backup vehicles, and the cost and refueling hassle of operating the backup vehicle. This method is implemented with a sample of 36,664 drivers, representing U.S. new car drivers, based on the 2009 National Household Travel Survey data. Key findings are: 1) Assuming the near term (2015) battery cost at $405/kWh, about 98% of the sampled drivers are predicted to prefer a range below 200 miles, and about 70% below 100 miles. The most popular 20-mile band of range is 57 to77 miles, unsurprisingly encompassing the Leaf s EPA-certified 73-mile range. With range limited to 4 or 7 discrete options, the majority are predicted to choose a range below 100 miles. 2) Found as a statistically robust rule of thumb, the BEV optimal range is approximately 0.6% of one s annual driving distance. 3) Reducing battery costs could motivate demand for larger range, but improving public charging may cause the opposite. 4) Using a single range to represent BEVs in analysis could significantly underestimate their competitiveness e.g. by $3226/vehicle if BEVs are represented with 73-mile range only or by $7404/BEV if with 150-mile range only. Range optimization and diversification into 4 or 7 range options reduce such analytical bias by 78% or 90%, respectively.

  5. Workplace Charging Challenge Partner: JLA Public Involvement...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Purchasing a plug-in electric vehicle (PEV) and installing a charging station has expanded JLA Public Involvement's sustainability efforts and allowed them to achieve Gold ...

  6. Central Plateau Principles Public Involvement Advice DETAILED...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    v0, 12914 Central Plateau Principles Public Involvement Advice DETAILED BACKGROUND Cleanup of Hanford's Central Plateau is expected to take another four decades or longer, and...

  7. Public Involvement and Communications Committee Summaries - Hanford...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    05, 2012 Final Attachment 1: Tri-Party Agreement Agencies - Public Involvement Calendar Fiscal Year 2012 - not available Attachment 2: PIC Meeting Transcribed Flip Chart Notes...

  8. Electrorefining Experience For Pyrochemical Reprocessing of Spent EBR-II Driver Fuel

    SciTech Connect (OSTI)

    S. X. Li; T. A. Johnson; B. R. Westphal; K. M. Goff; R. W. Benedict

    2005-10-01

    Pyrochemical processing has been implemented for the treatment of spent fuel from the Experimental Breeder Reactor-II (EBR-II) at Idaho National Laboratory since 1996. This report summarizes technical advancements made in electrorefining of spent EBR-II driver fuel in the Mk-IV electrorefiner since the pyrochemical processing was integrated into the AFCI program in 2002. The significant advancements include improving uranium dissolution and noble metal retention from chopped fuel segments, increasing cathode current efficiency, and achieving co-collection of zirconium along with uranium from the cadmium pool.

  9. Overview of proton drivers for neutrino super beams and neutrino factories

    SciTech Connect (OSTI)

    Chou, W.; /Fermilab

    2006-06-01

    There has been a world-wide interest in Proton Drivers in the past decade. Numerous design proposals have been presented in Asia, Europe and North America, ranging from low energy rapid cycling synchrotrons, normal or superconducting linacs to high energy slow cycling synchrotrons and FFAGs. One thing in common is that all these machines provide MW beam power and are used primarily for neutrino experiments. This paper gives an overview of these activities. In the last section the author expresses his personal opinion on the future of this field.

  10. Low-jitter high-power thyristor array pulse driver and generator

    DOE Patents [OSTI]

    Hanks, Roy L. (Byron, CA)

    2002-01-01

    A method and apparatus for generating low-jitter, high-voltage and high-current pulses for driving low impedance loads such as detonator fuses uses a MOSFET driver which, when triggered, discharges a high-voltage pre-charged capacitor into the primary of a toroidal current-multiplying transformer with multiple isolated secondary windings. The secondary outputs are suitable for driving an array of thyristors that discharge a precharged high-voltage capacitor and thus generating the required high-voltage and high-current pulse.

  11. Linear beam raster magnet driver based on H-bridge technique

    DOE Patents [OSTI]

    Sinkine, Nikolai I.; Yan, Chen; Apeldoorn, Cornelis; Dail, Jeffrey Glenn; Wojcik, Randolph Frank; Gunning, William

    2006-06-06

    An improved raster magnet driver for a linear particle beam is based on an H-bridge technique. Four branches of power HEXFETs form a two-by-two switch. Switching the HEXFETs in a predetermined order and at the right frequency produces a triangular current waveform. An H-bridge controller controls switching sequence and timing. The magnetic field of the coil follows the shape of the waveform and thus steers the beam using a triangular rather than a sinusoidal waveform. The system produces a raster pattern having a highly uniform raster density distribution, eliminates target heating from non-uniform raster density distributions, and produces higher levels of beam current.

  12. How to access older versions of rates? | OpenEI Community

    Open Energy Info (EERE)

    How to access older versions of rates? Home > Groups > Developer In drawing utility rate data from the API, there is a 'revisions' field in the JSON but there are not versions...

  13. Outcomes After Intensity-Modulated Versus Conformal Radiotherapy in Older Men With Nonmetastatic Prostate Cancer

    SciTech Connect (OSTI)

    Bekelman, Justin E.; Mitra, Nandita; Efstathiou, Jason; Liao Kaijun; Sunderland, Robert; Yeboa, Deborah N.; Armstrong, Katrina

    2011-11-15

    Purpose: There is little evidence comparing complications after intensity-modulated (IMRT) vs. three-dimensional conformal radiotherapy (CRT) for prostate cancer. The study objective was to test the hypothesis that IMRT, compared with CRT, is associated with a reduction in bowel, urinary, and erectile complications in elderly men with nonmetastatic prostate cancer. Methods and Materials: We undertook an observational cohort study using registry and administrative claims data from the SEER-Medicare database. We identified men aged 65 years or older diagnosed with nonmetastatic prostate cancer in the United States between 2002 and 2004 who received IMRT (n = 5,845) or CRT (n = 6,753). The primary outcome was a composite measure of bowel complications. Secondary outcomes were composite measures of urinary and erectile complications. We also examined specific subsets of bowel (proctitis/hemorrhage) and urinary (cystitis/hematuria) events within the composite complication measures. Results: IMRT was associated with reductions in composite bowel complications (24-month cumulative incidence 18.8% vs. 22.5%; hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.79-0.93) and proctitis/hemorrhage (HR 0.78; 95% CI, 0.64-0.95). IMRT was not associated with rates of composite urinary complications (HR 0.93; 95% CI, 0.83-1.04) or cystitis/hematuria (HR 0.94; 95% CI, 0.83-1.07). The incidence of erectile complications involving invasive procedures was low and did not differ significantly between groups, although IMRT was associated with an increase in new diagnoses of impotence (HR 1.27, 95% CI, 1.14-1.42). Conclusion: IMRT is associated with a small reduction in composite bowel complications and proctitis/hemorrhage compared with CRT in elderly men with nonmetastatic prostate cancer.

  14. Mound Site Community Involvement Plan 2012

    Office of Legacy Management (LM)

    Involvement Plan for the U.S. Department of Energy Mound, Ohio, Site January 2015 LMS/MND/S02885-0.0 This page intentionally left blank U.S. Department of Energy Mound Community Involvement Plan January 2015 Doc. No. S02885-0.0 Page i Contents Abbreviations .................................................................................................................................. ii 1.0 Purpose and Introduction

  15. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    November 2, 2011 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING November 2, 2011 Kennewick, WA Topics in this Meeting Summary Welcome and Introductions ............................................................................................................ 1 Responses to Board Advice 239 and 240 ....................................................................................... 1 Public Involvement for the Hanford Site-wide Permit

  16. Reliability and Failure Modes of Solid-State Lighting Electrical Drivers Subjected to Accelerated Aging

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lall, Pradeep; Sakalaukus, Peter; Davis, Lynn

    2015-02-19

    An investigation of an off-the-shelf solid-state lighting device with the primary focus on the accompanied light-emitting diode (LED) electrical driver (ED) has been conducted. A set of 10 EDs were exposed to temperature humidity life testing of 85% RH and 85 C (85/85) without an electrical bias per the JEDEC standard JESD22-A101C in order to accelerate the ingress of moisture into the aluminum electrolytic capacitor (AEC) and the EDs in order to assess the reliability of the LED drivers for harsh environment applications. The capacitance and equivalent series resistance for each AEC inside the ED were measured using a handheldmore » LCR meter as possible leading indications of failure. The photometric quantities of a single pristine light engine were monitored in order to investigate the interaction between the light engine and the EDs. These parameters were used in assessing the overall reliability of the EDs. In addition, a comparative analysis has been conducted between the 85/85 accelerated test data and a previously published high-temperature storage life accelerated test of 135°C. The results of the 85/85 acceleration test and the comparative analysis are presented in this paper.« less

  17. Breakeven Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities (Report Summary) (Presentation)

    SciTech Connect (OSTI)

    Denholm, P.; Margolis, R. M.; Ong, S.; Roberts, B.

    2009-12-01

    "Break-even cost" for photovoltaic (PV) technology is defined as the point where the cost of PV-generated electricity equals the cost of electricity purchased from the grid. Break-even cost is expressed in $/W of an installed system. Achieving break-even cost is a function of many variables. Consequently, break-even costs vary by location and time for a country, such as the United States, with a diverse set of resources, electricity prices, and other variables. In this presentation, we introduce an analysis of PV break-even costs for residential customers in the United States, including an evaluation of some of the key drivers of PV breakeven both regionally and over time. This presentation includes our methodology and presents results for both near-term residential breakeven costs(2009) and future market sensitivities of break-even costs (2015). See also the the report "Break-Even Cost for Residential Photovoltaics in the United States: Key Drivers and Sensitivities". Presentation for NREL/TP-6A2-45991.

  18. Reliability and Failure Modes of Solid-State Lighting Electrical Drivers Subjected to Accelerated Aging

    SciTech Connect (OSTI)

    Lall, Pradeep; Sakalaukus, Peter; Davis, Lynn

    2015-02-19

    An investigation of an off-the-shelf solid-state lighting device with the primary focus on the accompanied light-emitting diode (LED) electrical driver (ED) has been conducted. A set of 10 EDs were exposed to temperature humidity life testing of 85% RH and 85 C (85/85) without an electrical bias per the JEDEC standard JESD22-A101C in order to accelerate the ingress of moisture into the aluminum electrolytic capacitor (AEC) and the EDs in order to assess the reliability of the LED drivers for harsh environment applications. The capacitance and equivalent series resistance for each AEC inside the ED were measured using a handheld LCR meter as possible leading indications of failure. The photometric quantities of a single pristine light engine were monitored in order to investigate the interaction between the light engine and the EDs. These parameters were used in assessing the overall reliability of the EDs. In addition, a comparative analysis has been conducted between the 85/85 accelerated test data and a previously published high-temperature storage life accelerated test of 135°C. The results of the 85/85 acceleration test and the comparative analysis are presented in this paper.

  19. Optimizing and Diversifying Electric Vehicle Driving Range for U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong

    2014-08-11

    Properly determining the driving range is critical for accurately predicting the sales and social benefits of battery electric vehicles (BEVs). This study proposes a framework for optimizing the driving range by minimizing the sum of battery price, electricity cost, and range limitation cost referred to as the "range-related cost" as a measurement of range anxiety. The objective function is linked to policy-relevant parameters, including battery cost and price markup, battery utilization, charging infrastructure availability, vehicle efficiency, electricity and gasoline prices, household vehicle ownership, daily driving patterns, discount rate, and perceived vehicle lifetime. Qualitative discussion of the framework and its empirical application to a sample (N=36664) representing new car drivers in the United States is included. The quantitative results strongly suggest that ranges of less than 100 miles are likely to be more popular in the BEV market for a long period of time. The average optimal range among U.S. drivers is found to be largely inelastic. Still, battery cost reduction significantly drives BEV demand toward longer ranges, whereas improvement in the charging infrastructure is found to significantly drive BEV demand toward shorter ranges. In conclusion, the bias of a single-range assumption and the effects of range optimization and diversification in reducing such biases are both found to be significant.

  20. Elise - the next step in development of induction heavy ion drivers for inertial fusion energy

    SciTech Connect (OSTI)

    Lee, E.; Bangerter, R.O.; Celata, C.; Faltens, A.; Fessenden, T.; Peters, C.; Pickrell, J.; Reginato, L.; Seidl, P.; Yu, S.

    1994-11-01

    LBL, with the participation of LLNL and industry, proposes to build Elise, an electric-focused accelerator as the next logical step towards the eventual goal of a heavy-ion induction linac powerful enough to implode or {open_quotes}drive{close_quotes} inertial-confinement fusion targets. Elise will be at full driver scale in several important parameters-most notably line charge density (a function of beam size), which was not explored in earlier experiments. Elise will be capable of accelerating and electrostatically focusing four parallel, full-scale ion beams and will be designed to be extendible, by successive future construction projects, to meet the goal of the USA DOE Inertial Fusion Energy program (IFE). This goal is to address all remaining issues in heavy-ion IFE except target physics, which is currently the responsibility of DOE Defense Programs, and the target chamber. Thus Elise is the first step of a program that will provide a solid foundation of data for further progress toward a driver, as called for in the National Energy Strategy and National Energy Policy Act.

  1. Optimizing and Diversifying Electric Vehicle Driving Range for U.S. Drivers

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lin, Zhenhong

    2014-08-11

    Properly determining the driving range is critical for accurately predicting the sales and social benefits of battery electric vehicles (BEVs). This study proposes a framework for optimizing the driving range by minimizing the sum of battery price, electricity cost, and range limitation cost referred to as the "range-related cost" as a measurement of range anxiety. The objective function is linked to policy-relevant parameters, including battery cost and price markup, battery utilization, charging infrastructure availability, vehicle efficiency, electricity and gasoline prices, household vehicle ownership, daily driving patterns, discount rate, and perceived vehicle lifetime. Qualitative discussion of the framework and its empiricalmore » application to a sample (N=36664) representing new car drivers in the United States is included. The quantitative results strongly suggest that ranges of less than 100 miles are likely to be more popular in the BEV market for a long period of time. The average optimal range among U.S. drivers is found to be largely inelastic. Still, battery cost reduction significantly drives BEV demand toward longer ranges, whereas improvement in the charging infrastructure is found to significantly drive BEV demand toward shorter ranges. In conclusion, the bias of a single-range assumption and the effects of range optimization and diversification in reducing such biases are both found to be significant.« less

  2. Optimizing and Diversifying Electric Vehicle Driving Range for U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong

    2014-01-01

    Properly determining the driving range is critical for accurately predicting the sales and social benefits of battery electric vehicles (BEVs). This study proposes a framework for optimizing the driving range by minimizing the sum of battery price, electricity cost, and range limitation cost referred to as the range-related cost as a measurement of range anxiety. The objective function is linked to policy-relevant parameters, including battery cost and price markup, battery utilization, charging infrastructure availability, vehicle efficiency, electricity and gasoline prices, household vehicle ownership, daily driving patterns, discount rate, and perceived vehicle lifetime. Qualitative discussion of the framework and its empirical application to a sample (N=36,664) representing new car drivers in the United States is included. The quantitative results strongly suggest that ranges of less than 100 miles are likely to be more popular in the BEV market for a long period of time. The average optimal range among U.S. drivers is found to be largely inelastic. Still, battery cost reduction significantly drives BEV demand toward longer ranges, whereas improvement in the charging infrastructure is found to significantly drive BEV demand toward shorter ranges. The bias of a single-range assumption and the effects of range optimization and diversification in reducing such biases are both found to be significant.

  3. Health Physics Code System for Evaluating Accidents Involving Radioactive Materials.

    Energy Science and Technology Software Center (OSTI)

    2014-10-01

    Version 03 The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculational tool for evaluating accidents involving radioactive materials. HOTSPOT codes provide a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. The developer's website is: http://www.llnl.gov/nhi/hotspot/. Four general programs, PLUME, EXPLOSION, FIRE, and RESUSPENSION, calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosivemore » release, fuel fire, or an area contamination event. Additional programs deal specifically with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. The FIDLER program can calibrate radiation survey instruments for ground survey measurements and initial screening of personnel for possible plutonium uptake in the lung. The HOTSPOT codes are fast, portable, easy to use, and fully documented in electronic help files. HOTSPOT supports color high resolution monitors and printers for concentration plots and contours. The codes have been extensively used by the DOS community since 1985. Tables and graphical output can be directed to the computer screen, printer, or a disk file. The graphical output consists of dose and ground contamination as a function of plume centerline downwind distance, and radiation dose and ground contamination contours. Users have the option of displaying scenario text on the plots. HOTSPOT 3.0.1 fixes three significant Windows 7 issues: � Executable installed properly under "Program Files/HotSpot 3.0". Installation package now smaller: removed dependency on older Windows DLL files which previously needed to \\ � Forms now properly scale based on DPI instead of font for users who change their screen resolution to something other than 100%. This is a more common feature in Windows 7

  4. Strategic Public Involvement Products For Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Involvement Products For Review PIC Discussion September 4, 2013 1 This list is from July 7, 2010 before we had decided on writing advice and is purely for reference for...

  5. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 13, 2011 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING January 13, 2011 Richland, WA Topics in this Meeting Summary Welcome and Introductions ............................................................................................................ 1 State of the Site Meetings ............................................................................................................... 2 Open Government Plan Advice

  6. Department of Energy Idaho - Public Involvement Opportunity

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Public Involvement Opportunity Public Involvement Opportunities Free Acrobat Reader Link Many of the documents provided are in the Adobe PDF format. If you do not have the latest version or do not have the Acrobat Reader, you may download the Reader FREE by clicking on the icon at left. If you experience problems in reading the files please down load the latest free Adobe® Reader. Current Documents for Review and Public Comment: Idaho-Related National Environmental Policy Act (NEPA) Documents

  7. Global and Regional Ecosystem Modeling: Databases of Model Drivers and Validation Measurements

    SciTech Connect (OSTI)

    Olson, R.J.

    2002-03-19

    Understanding global-scale ecosystem responses to changing environmental conditions is important both as a scientific question and as the basis for making policy decisions. The confidence in regional models depends on how well the field data used to develop the model represent the region of interest, how well the environmental model driving variables (e.g., vegetation type, climate, and soils associated with a site used to parameterize ecosystem models) represent the region of interest, and how well regional model predictions agree with observed data for the region. To assess the accuracy of global model forecasts of terrestrial carbon cycling, two Ecosystem Model-Data Intercomparison (EMDI) workshops were held (December 1999 and April 2001). The workshops included 17 biogeochemical, satellite-driven, detailed process, and dynamic vegetation global model types. The approach was to run regional or global versions of the models for sites with net primary productivity (NPP) measurements (i.e., not fine-tuned for specific site conditions) and analyze the model-data differences. Extensive worldwide NPP data were assembled with model driver data, including vegetation, climate, and soils data, to perform the intercomparison. This report describes the compilation of NPP estimates for 2,523 sites and 5,164 0.5{sup o}-grid cells under the Global Primary Production Data Initiative (GPPDI) and the results of the EMDI review and outlier analysis that produced a refined set of NPP estimates and model driver data. The EMDI process resulted in 81 Class A sites, 933 Class B sites, and 3,855 Class C cells derived from the original synthesis of NPP measurements and associated driver data. Class A sites represent well-documented study sites that have complete aboveground and below ground NPP measurements. Class B sites represent more numerous ''extensive'' sites with less documentation and site-specific information available. Class C cells represent estimates of NPP for 0.5{sup o

  8. HIGH-POWER FFAG-BASED HEAVY-ION AND PROTON DRIVERS

    SciTech Connect (OSTI)

    RUGGIERO,A.

    2007-10-01

    Fixed-Field Alternating-Gradient (FFAG) accelerators are being proposed as an alternative to Super-conducting Linacs (SCL), Rapid-Cycling Synchrotrons (RCS) and Cyclotrons for the acceleration of very intense Heavy-Ion and Proton beams in the medium energy range. One application is the acceleration of ions of Uranium-238 to an energy of 400 MeV/u, and the average power of 400 kWatt, and the other a 1-GeV Proton Driver with an average beam power of 10 MWatt. One or two FFAG rings are needed for acceleration of both beams. They adopt a Non-Scaling Lattice (NSL) to reduce the size and the cost of the accelerator. The continuous wave (CW) mode of operation is achieved with the method of Harmonic Number Jump (HNJ).

  9. Rotating fiber array molecular driver and molecular momentum transfer device constructed therewith

    DOE Patents [OSTI]

    Milleron, Norman

    1983-01-01

    A rotating fiber array molecular driver is disclosed which includes a magnetically suspended and rotated central hub to which is attached a plurality of elongated fibers extending radially therefrom. The hub is rotated so as to straighten and axially extend the fibers and to provide the fibers with a tip speed which exceeds the average molecular velocity of fluid molecules entering between the fibers. Molecules colliding with the sides of the rotating fibers are accelerated to the tip speed of the fiber and given a momentum having a directional orientation within a relatively narrow distribution angle at a point radially outward of the hub, which is centered and peaks at the normal to the fiber sides in the direction of fiber rotation. The rotating fiber array may be used with other like fiber arrays or with other stationary structures to form molecular momentum transfer devices such as vacuum pumps, molecular separators, molecular coaters, or molecular reactors.

  10. Brazil’s Biofuels Scenario: What are the Main Drivers Which will Shape Investments in the Long Term?

    Broader source: Energy.gov [DOE]

    Breakout Session 3C—Fostering Technology Adoption III: International Market Opportunities in Bioenergy Brazil’s Biofuels Scenario: What are the Main Drivers Which will Shape Investments in the Long Term? Artur Milanez, Manager of Biofuels Department, Brazilian Development Bank

  11. Geological characterization of permian submarine fan reservoirs of the driver waterflood unit, Spraberry Trend, Midland Basin, Texas

    SciTech Connect (OSTI)

    Guevara, E.H.

    1989-01-01

    This book discusses the geological characterization and assessment of the relationship between reservoir stratigraphy and oil recovery of the Driver waterflood unit of the Spraberry Trend, Midland Basin, West Texas. In this study , the author focuses on the Driver waterflood unit, which is located in Midland, Glasscock, Upton, and Reagan Counties and is part of the giant Spraberry Trend currently being studied by the Bureau. Gamma-ray logs and scout cards from more than 350 wells and slabbed cores from 2 wells, along with core analyses and production data, provided the main sources of information for the study. Fifteen log-defined genetic-stratigraphic operational units were delineated in the Spraberry Formation and were correlated throughout the study area to define the stratigraphic framework. The text presents net sandstone and siltstone maps, cross sections, depth plots of core analyses, and maps of production data. The author describes the depositional systems and hydrocarbon distribution in the Driver unit (currently operated by Standard Oil), details the influence of reservoir stratigraphy on oil recovery, and outlines opportunities for additional recovery. He notes that reservoir management strategies must take into account the stratigraphic heterogeneities of accumulations in the unit. He concludes that a program of selective recompletions and infill drilling based on knowledge of both reservoir stratigraphy and natural fractures is the key to improving oil recovery from the Driver unit in particular and from the Spraberry Trend in general.

  12. Fact #845: November 3, 2014 From 1970 to 2013 the Share of Older Vehicles in Operation has Increased – Dataset

    Broader source: Energy.gov [DOE]

    Excel file with dataset for Fact #845: From 1970 to 2013 the Share of Older Vehicles in Operation has Increased

  13. Manager`s views of public involvement

    SciTech Connect (OSTI)

    Branch, K.M.; Heerwagen, J.; Bradbury, J.

    1995-12-01

    Four issues commonly form the framework for debates about the acceptability of proposed projects or technologies--the substantive decision or technological choice; the treatment of the community by the proponent organization; the way the decision-making process has been structured and managed; and the status of institutional safeguards and protection. One of the clear messages of cultural theory is that differences in perspectives are a normal and inevitable part of society, and that attempts to resolve differences by persuasion are not likely to work. These findings are useful when considering the goals and possibilities of public involvement as a decision-making tool, and when designing or evaluating public involvement training programs for managers. The research reported here examines the viewpoints and concerns of managers and decision-makers about the four issues identified above, with particular emphasis on their perspectives and concerns about opening decision-making processes to the public and about managers` roles and responsibilities for structuring and managing open decision-making processes. Implications of these findings for public involvement training for managers is also discussed. The data presented in this paper were obtained from face-to-face interviews with managers and decision-makers with experience managing a variety of hazardous waste management decision-making processes. We conducted these interviews in the course of four separate research projects: needs assessments to support the design and development of a public involvement training program for managers; a study of community residents` and managers` perspectives on the chemical stockpile disposal program; an evaluation of the effectiveness of public involvement training for managers in the Department of Energy; and a study to develop indicators of the benefits and costs of public involvement.

  14. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 1, 2011 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD PUBLIC INVOLVEMENT & COMMUNICATIONS COMMITTEE MEETING June 1, 2011 Kennewick, WA Topics in this Meeting Summary Welcome and Introductions .......................................................................................................................... 1 Comprehensive Debrief - State of the Site Meetings ................................................................................... 4 Public Meetings - PW-1/3/6 and CW-5

  15. Sandia National Laboratories: Community Involvement: Volunteer Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Community Involvement Contribution Programs Volunteer Programs Education Programs About Volunteer Programs Helping where we are needed Habitat for Humanity Employees and retirees are passionate about volunteering. You'll find Sandians judging science fairs, coaching sports teams, leading scouting troops, sorting food, building houses, and serving on community boards. In support of individual volunteer efforts, Sandia provides a volunteer website to advertise current volunteer opportunities and

  16. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs: Science, Technology, Engineering and Math Programs Science, Technology, Engineering, and Math Programs Future scientists photo Our science, technology, engineering, and math (STEM) programs engage students by linking science to the real world. We offer three unique programs for American Indian students, African American students, and Hispanic students. The programs get students involved in fun, hands-on science and engineering activities and provide an opportunity to

  17. Studies Of Coherent Synchrotron Radiation And Longitudinal Space Charge In The Jefferson Lab FEL Driver

    SciTech Connect (OSTI)

    Tennant, Christopher D.; Douglas, David R.; Li, Rui; Tsai, C.-Y.

    2014-12-01

    The Jefferson Laboratory IR FEL Driver provides an ideal test bed for studying a variety of beam dynamical effects. Recent studies focused on characterizing the impact of coherent synchrotron radiation (CSR) with the goal of benchmarking measurements with simulation. Following measurements to characterize the beam, we quantitatively characterized energy extraction via CSR by measuring beam position at a dispersed location as a function of bunch compression. In addition to operating with the beam on the rising part of the linac RF waveform, measurements were also made while accelerating on the falling part. For each, the full compression point was moved along the backleg of the machine and the response of the beam (distribution, extracted energy) measured. Initial results of start-to-end simulations using a 1D CSR algorithm show remarkably good agreement with measurements. A subsequent experiment established lasing with the beam accelerated on the falling side of the RF waveform in conjunction with positive momentum compaction (R56) to compress the bunch. The success of this experiment motivated the design of a modified CEBAF-style arc with control of CSR and microbunching effects.

  18. Simple Limits on Achieving A Quasi-Linear Magnetic Compression for an FEL Driver

    SciTech Connect (OSTI)

    Sun, Yipeng; /SLAC

    2012-02-16

    Free electron lasers (FEL) need a very bright electron beam in three dimensions and a high peak charge density. In order to compress an initially longer electron bunch generated from the photoinjector, magnetic bunch compression systems are widely employed. In this paper, first harmonic RF linearization and its associated requirements are reviewed. Meanwhile it is also briefly discussed what is the relation between a proper initial bunch length and main RF frequency, when a harmonic RF linearization is included. Then given a reasonable bunch compression ratio, a proper initial bunch length as a function of the main RF frequency and RF phase is estimated analytically by several approaches, assuming that no harmonic RF section is needed to linearize the energy modulation introduced during main RF acceleration, and at the same time still linearly compress the bunch length. Next the upper limit of the bunch compression ratio in a single stage is evaluated analytically. The analytical relations derived on choosing a proper initial bunch length as a function of main RF frequency are confirmed by numerical simulation. These simple limit provide rough estimations and may be beneficial for choosing bunch compression ratios in different stages of an FEL driver, especially in a first stage bunch compression where there is usually a harmonic RF linearization applied. It may also be useful in evaluating the possibility of low charge operation mode without any harmonic RF linearization, where a shorter initial bunch length can be achieved from the photoinjector.

  19. Performance of the accelerator driver of Jefferson Laboratory's free-electron laser

    SciTech Connect (OSTI)

    Bohn, C.L.; Benson, S.; Biallas, G.

    1999-04-01

    The driver of Jefferson Lab's kW-level infrared free-electron laser (FEL) is a superconducting, recirculating accelerator that recovers about 75% of the electron-beam power and converts it to radiofrequency power. In achieving first lasing, the accelerator operated straight-ahead to deliver 38 MeV, 1.1 mA cw current through the wiggler for lasing at wavelengths in the vicinity of 5 {mu}m. Just prior to first lasing, measured rms beam properties at the wiggler were 7.5{+-}1.5 mm-mr normalized transverse emittance, 26{+-}7 keV-deg longitudinal emittance, and 0.4{+-}0.1 ps bunch length which yielded a peak current of 60{+-}15A. The waste beam was then sent directly to a dump, bypassing the recirculation loop. Stable operation at up to 311 W cw was achieved in this mode. Commissioning the recirculation loop then proceeded. As of this Conference, the machine has recirculated cw average current up to 4 mA, and has lased cw with energy recover up to 710 W.

  20. Design of the SRF Driver ERL for the Jefferson Lab UV FEL

    SciTech Connect (OSTI)

    David R. Douglas; Stephen Benson; George Biallas; Keith Blackburn; James Boyce; Donald Bullard; James Coleman; Cody Dickover; Forrest Ellingsworth; Pavel Evtushenko; Christopher Gould; Joseph Gubeli; Fay Hannon; David Hardy; Carlos Hernandez-Garcia; Kevin Jordan; Michael Klopf; James Kortze; Matthew Marchlik; Steven Moore; George Neil; Thomas Powers; Daniel Sexton; Michelle D. Shinn; Christopher Tennant; Richard Walker; Frederick Wilson; Shukui Zhang

    2011-03-01

    We describe the design of the SRF Energy-Recovering Linac (ERL) providing the CW electron drive beam at the Jefferson Lab UV FEL. Based on the same 135 MeV linear accelerator as – and sharing portions of the recirculator with – the Jefferson Lab 10 kW IR Upgrade FEL, the UV driver ERL uses a novel bypass geometry to provide transverse phase space control, bunch length compression, and nonlinear aberration compensation (including correction of RF curvature effects) without the use of magnetic chicanes or harmonic RF. Stringent phase space requirements at the wiggler, low beam energy, high beam current, and use of a pre-existing facility and legacy hardware subject the design to numerous constraints. These are imposed not only by the need for both transverse and longitudinal phase space management, but also by the potential impact of collective phenomena (space charge, wakefields, beam break-up (BBU), and coherent synchrotron radiation (CSR)), and by interactions between the FEL and the accelerator RF system. This report addresses these issues and presents the accelerator design solution that is now in operation.

  1. Use of Multipass Recirculation and Energy Recovery In CW SRF X-FEL Driver Accelerators

    SciTech Connect (OSTI)

    Douglas, David; Akers, Walt; Benson, Stephen V.; Biallas, George; Blackburn, Keith; Boyce, James; Bullard, Donald; Coleman, James; Dickover, Cody; Ellingsworth, Forrest; Evtushenko, Pavel; Fisk, Sally; Gould, Christopher; Gubeli, Joseph; Hannon, Fay; Hardy, David; Hernandez-Garcia, Carlos; Jordan, Kevin; Klopf, John; Kortze, J.; Legg, Robert; Li, Rui; Marchlik, Matthew; Moore, Steven W.; Neil, George; Powers, Thomas; Sexton, Daniel; Shin, Ilkyoung; Shinn, Michelle D.; Tennant, Christopher; Terzic, Balsa; Walker, Richard; Williams, Gwyn P.; Wilson, G.; Zhang, Shukui

    2010-08-01

    We discuss the use of multipass recirculation and energy recovery in CW SRF drivers for short wavelength FELs. Benefits include cost management (through reduced system footprint, required RF and SRF hardware, and associated infrastructure - including high power beam dumps and cryogenic systems), ease in radiation control (low drive beam exhaust energy), ability to accelerate and deliver multiple beams of differing energy to multiple FELs, and opportunity for seamless integration of multistage bunch length compression into the longitudinal matching scenario. Issues include all those associated with ERLs compounded by the challenge of generating and preserving the CW electron drive beam brightness required by short wavelength FELs. We thus consider the impact of space charge, BBU and other environmental wakes and impedances, ISR and CSR, potential for microbunching, intra-beam and beam-residual gas scattering, ion effects, RF transients, and halo, as well as the effect of traditional design, fabrication, installation and operational errors (lattice aberrations, alignment, powering, field quality). Context for the discussion is provided by JLAMP, the proposed VUV/X-ray upgrade to the existing Jefferson Lab FEL.

  2. Lorentz and CPT tests involving antiprotons

    SciTech Connect (OSTI)

    Lehnert, Ralf

    2005-10-19

    Perhaps the largest gap in our understanding of nature at the smallest scales is a consistent quantum theory underlying the Standard Model and General Relativity. Substantial theoretical research has been performed in this context, but observational efforts are hampered by the expected Planck suppression of deviations from conventional physics. However, a variety of candidate models predict minute violations of both Lorentz and CPT invariance. Such effects open a promising avenue for experimental research in this field because these symmetries are amenable to Planck-precision tests.The low-energy signatures of Lorentz and CPT breaking are described by an effective field theory called the Standard-Model Extension (SME). In addition to the body of established physics (i.e., the Standard Model and General Relativity), this framework incorporates all Lorentz- and CPT-violating corrections compatible with key principles of physics. To date, the SME has provided the basis for the analysis of numerous tests of Lorentz and CPT symmetry involving protons, neutrons, electrons, muons, and photons. Discovery potential exists in neutrino physics.A particularly promising class of Planck-scale tests involve matter-antimatter comparisons at low temperatures. SME predictions for transition frequencies in such systems include both matter-antimatter differences and sidereal variations. For example, in hydrogen-antihydrogen spectroscopy, leading-order effects in a 1S-2S transition as well as in a 1S Zeeman transition could exist that can be employed to obtain clean constraints. Similarly, tight bounds can be obtained from Penning-trap experiments involving antiprotons.

  3. Radiative Decays Involving Light Scalar Mesons

    SciTech Connect (OSTI)

    Deirdre Black; Masayasu Harada; Joseph Schechter

    2002-09-01

    We present a vector dominance model to describe radiative decays involving the light scalar mesons. Assuming that the light scalar mesons form a nonet this model gives relations among various decay amplitudes of the form S--> gamma gamma, V-->Sgamma and S--> Vgamma, where S and V denote scalar and vector mesons. By comparing with experimental radiative decay rates, including those recently measured for phi--> PP'gamma, we obtain various predictions. We discuss briefly ongoing extensions of the present work in an attempt to describe the radiative phi decay measurements in detail.

  4. Assessing Energy Impact of Plug-In Hybrid Electric Vehicles: Significance of Daily Distance Variation over Time and Among Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong [ORNL; Greene, David L [ORNL

    2012-01-01

    Accurate assessment of the impact of plug-in hybrid electric vehicles (PHEVs) on petroleum and electricity consumption is a necessary step toward effective policies. Variations in daily vehicle miles traveled (VMT) over time and among drivers affect PHEV energy impact, but the significance is not well understood. This paper uses a graphical illustration, a mathematical derivation, and an empirical study to examine the cause and significance of such an effect. The first two methods reveal that ignoring daily variation in VMT always causes underestimation of petroleum consumption and overestimation of electricity consumption by PHEVs; both biases increase as the assumed PHEV charge-depleting (CD) range moves closer to the average daily VMT. The empirical analysis based on national travel survey data shows that the assumption of uniform daily VMT over time and among drivers causes nearly 68% underestimation of expected petroleum use and nearly 48% overestimation of expected electricity use by PHEVs with a 40-mi CD range (PHEV40s). Also for PHEV40s, consideration of daily variation in VMT over time but not among drivers similar to the way the utility factor curve is derived in SAE Standard SAE J2841 causes underestimation of expected petroleum use by more than 24% and overestimation of expected electricity use by about 17%. Underestimation of petroleum use and overestimation of electricity use increase with larger-battery PHEVs.

  5. Feasibility of developing a portable driver performance data acquisition system for human factors research: Design specifications. Volume 3

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow driver performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During Phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volume 2 presents the related appendices. Volume three (this report) displays the design specifications developed for DASCAR during the ``develop design requirements and specifications for a portable driver performance data acquisition system`` task. Design specifications were assembled for each DASCAR element. The specifications were prepared in sufficient detail to allow a third party to use them to design, develop, procure, and subsequently construct the data acquisition system. This report also covers the background to the program.

  6. Apolipoprotein gene involved in lipid metabolism

    DOE Patents [OSTI]

    Rubin, Edward; Pennacchio, Len A.

    2007-07-03

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  7. An insight into actual energy use and its drivers in high-performance buildings

    SciTech Connect (OSTI)

    Li, Cheng; Hong, Tianzhen; Yan, Da

    2014-07-12

    Using portfolio analysis and individual detailed case studies, we studied the energy performance and drivers of energy use in 51 high-performance office buildings in the U.S., Europe, China, and other parts of Asia. Portfolio analyses revealed that actual site energy use intensity (EUI) of the study buildings varied by a factor of as much as 11, indicating significant variation in real energy use in HPBs worldwide. Nearly half of the buildings did not meet the American Society of Heating, Refrigerating, and Air Conditioning Engineers (ASHRAE) Standard 90.1-2004 energy target, raising questions about whether a building’s certification as high performing accurately indicates that a building is energy efficient and suggesting that improvement in the design and operation of HPBs is needed to realize their energy-saving potential. We studied the influence of climate, building size, and building technologies on building energy performance and found that although all are important, none are decisive factors in building energy use. EUIs were widely scattered in all climate zones. There was a trend toward low energy use in small buildings, but the correlation was not absolute; some small HPBs exhibited high energy use, and some large HPBs exhibited low energy use. We were unable to identify a set of efficient technologies that correlated directly to low EUIs. In two case studies, we investigated the influence of occupant behavior as well as operation and maintenance on energy performance and found that both play significant roles in realizing energy savings. We conclude that no single factor determines the actual energy performance of HPBs, and adding multiple efficient technologies does not necessarily improve building energy performance; therefore, an integrated design approach that takes account of climate, technology, occupant behavior, and operations and maintenance practices should be implemented to maximize energy savings in HPBs. As a result, these findings are

  8. First Argon Gas Puff Experiments With 500 ns Implosion Time On Sphinx Driver

    SciTech Connect (OSTI)

    Zucchini, F.; Calamy, H.; Lassalle, F.; Loyen, A.; Maury, P.; Grunenwald, J.; Georges, A.; Morell, A.; Bedoch, J.-P.; Ritter, S.; Combes, P.; Smaniotto, O.; Lample, R.; Coleman, P. L.; Krishnan, M.

    2009-01-21

    Experiments have been performed at the SPHINX driver to study potential of an Argon Gas Puff load designed by AASC. We present here the gas Puff hardware and results of the last shot series.The Argon Gas Puff load used is injected thanks to a 20 cm diameter nozzle. The nozzle has two annuli and a central jet. The pressure and gas type in each of the nozzle plena can be independently adjusted to tailor the initial gaz density distribution. This latter is selected as to obtain an increasing radial density from outer shell towards the pinch axis in order to mitigate the RT instabilities and to increase radiating mass on axis. A flashboard unit produces a high intensity UV source to pre-ionize the Argon gas. Typical dimensions of the load are 200 mm in diameter and 40 mm height. Pressures are adjusted to obtain an implosion time around 550 ns with a peak current of 3.5 MA.With the goal of improving k-shell yield a mass scan of the central jet was performed and implosion time, mainly given by outer and middle plena settings, was kept constant. Tests were also done to reduce the implosion time for two configurations of the central jet. Strong zippering of the radiation production was observed mainly due to the divergence of the central jet over the 40 mm of the load height. Due to that feature k-shell radiation is mainly obtained near cathode. Therefore tests were done to mitigate this effect first by adjusting local pressure of middle and central jet and second by shortening the pinch length.At the end of this series, best shot gave 5 kJ of Ar k-shell yield. PCD detectors showed that k-shell x-ray power was 670 GW with a FWHM of less than 10 ns.

  9. Energy for 500 Million Homes: Drivers and Outlook for Residential Energy Consumption in China

    SciTech Connect (OSTI)

    Zhou, Nan; McNeil, Michael A.; Levine, Mark

    2009-06-01

    China's rapid economic expansion has propelled it to the rank of the largest energy consuming nation in the world, with energy demand growth continuing at a pace commensurate with its economic growth. The urban population is expected to grow by 20 million every year, accompanied by construction of 2 billion square meters of buildings every year through 2020. Thus residential energy use is very likely to continue its very rapid growth. Understanding the underlying drivers of this growth helps to identify the key areas to analyze energy efficiency potential, appropriate policies to reduce energy use, as well as to understand future energy in the building sector. This paper provides a detailed, bottom-up analysis of residential building energy consumption in China using data from a wide variety of sources and a modelling effort that relies on a very detailed characterization of China's energy demand. It assesses the current energy situation with consideration of end use, intensity, and efficiency etc, and forecast the future outlook for the critical period extending to 2020, based on assumptions of likely patterns of economic activity, availability of energy services, technology improvement and energy intensities. From this analysis, we can conclude that Chinese residential energy consumption will more than double by 2020, from 6.6 EJ in 2000 to 15.9 EJ in 2020. This increase will be driven primarily by urbanization, in combination with increases in living standards. In the urban and higher income Chinese households of the future, most major appliances will be common, and heated and cooled areas will grow on average. These shifts will offset the relatively modest efficiency gains expected according to current government plans and policies already in place. Therefore, levelling and reduction of growth in residential energy demand in China will require a new set of more aggressive efficiency policies.

  10. An insight into actual energy use and its drivers in high-performance buildings

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Cheng; Hong, Tianzhen; Yan, Da

    2014-07-12

    Using portfolio analysis and individual detailed case studies, we studied the energy performance and drivers of energy use in 51 high-performance office buildings in the U.S., Europe, China, and other parts of Asia. Portfolio analyses revealed that actual site energy use intensity (EUI) of the study buildings varied by a factor of as much as 11, indicating significant variation in real energy use in HPBs worldwide. Nearly half of the buildings did not meet the American Society of Heating, Refrigerating, and Air Conditioning Engineers (ASHRAE) Standard 90.1-2004 energy target, raising questions about whether a building’s certification as high performing accuratelymore » indicates that a building is energy efficient and suggesting that improvement in the design and operation of HPBs is needed to realize their energy-saving potential. We studied the influence of climate, building size, and building technologies on building energy performance and found that although all are important, none are decisive factors in building energy use. EUIs were widely scattered in all climate zones. There was a trend toward low energy use in small buildings, but the correlation was not absolute; some small HPBs exhibited high energy use, and some large HPBs exhibited low energy use. We were unable to identify a set of efficient technologies that correlated directly to low EUIs. In two case studies, we investigated the influence of occupant behavior as well as operation and maintenance on energy performance and found that both play significant roles in realizing energy savings. We conclude that no single factor determines the actual energy performance of HPBs, and adding multiple efficient technologies does not necessarily improve building energy performance; therefore, an integrated design approach that takes account of climate, technology, occupant behavior, and operations and maintenance practices should be implemented to maximize energy savings in HPBs. As a result, these

  11. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  12. Agricultural green revolution as a driver of increasing atmospheric CO2 seasonal amplitude

    SciTech Connect (OSTI)

    Zeng, Ning; Zhao, Fang; Collatz, George; Kalnay, Eugenia; Salawitch, Ross J.; West, Tristram O.; Guanter, Luis

    2014-11-20

    The atmospheric carbon dioxide (CO2) record displays a prominent seasonal cycle that arises mainly from changes in vegetation growth and the corresponding CO2 uptake during the boreal spring and summer growing seasons and CO2 release during the autumn and winter seasons. The CO2 seasonal amplitude has increased over the past five decades, suggesting an increase in Northern Hemisphere biospheric activity. It has been proposed that vegetation growth may have been stimulated by higher concentrations of CO2 as well as by warming in recent decades, but such mechanisms have been unable to explain the full range and magnitude of the observed increase in CO2 seasonal amplitude. Here we suggest that the intensification of agriculture (the Green Revolution, in which much greater crop yield per unit area was achieved by hybridization, irrigation and fertilization) during the past five decades is a driver of changes in the seasonal characteristics of the global carbon cycle. Our analysis of CO2 data and atmospheric inversions shows a robust 15 per cent long-term increase in CO2 seasonal amplitude from 1961 to 2010, punctuated by large decadal and interannual variations. Using a terrestrial carbon cycle model that takes into account high-yield cultivars, fertilizer use and irrigation, we find that the long-term increase in CO2 seasonal amplitude arises from two major regions: the mid-latitude cropland between 256N and 606N and the high-latitude natural vegetation between 506N and 706 N. The long-term trend of seasonal amplitude increase is 0.311 ± 0.027 percent per year, of which sensitivity experiments attribute 45, 29 and 26 per cent to land-use change, climate variability and change, and increased productivity due to CO2 fertilization, respectively. Vegetation growth was earlier by one to two weeks, as measured by the mid-point of vegetation carbon uptake, and took up 0.5 petagrams more carbon in July, the height of the growing season, during 2001–2010 than in 1961–1970

  13. The North American Carbon Program Multi-scale Synthesis and Terrestrial Model Intercomparison Project – Part 2: Environmental driver data

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wei, Yaxing; Liu, Shishi; Huntzinger, Deborah N.; Michalak, Anna M.; Viovy, Nicolas; Post, Wilfred M.; Schwalm, Christopher R.; Schaeffer, Kevin; Jacobson, Andrew R.; Lu, Chaoqun; et al

    2014-12-05

    Ecosystems are important and dynamic components of the global carbon cycle, and terrestrial biospheric models (TBMs) are crucial tools in further understanding of how terrestrial carbon is stored and exchanged with the atmosphere across a variety of spatial and temporal scales. Improving TBM skills, and quantifying and reducing their estimation uncertainties, pose significant challenges. The Multi-scale Synthesis and Terrestrial Model Intercomparison Project (MsTMIP) is a formal multi-scale and multi-model intercomparison effort set up to tackle these challenges. The MsTMIP protocol prescribes standardized environmental driver data that are shared among model teams to facilitate model model and model observation comparisons. Inmore » this article, we describe the global and North American environmental driver data sets prepared for the MsTMIP activity to both support their use in MsTMIP and make these data, along with the processes used in selecting/processing these data, accessible to a broader audience. Based on project needs and lessons learned from past model intercomparison activities, we compiled climate, atmospheric CO2 concentrations, nitrogen deposition, land use and land cover change (LULCC), C3 / C4 grasses fractions, major crops, phenology and soil data into a standard format for global (0.5⁰ x 0.5⁰ resolution) and regional (North American: 0.25⁰ x 0.25⁰ resolution) simulations. In order to meet the needs of MsTMIP, improvements were made to several of the original environmental data sets, by improving the quality, and/or changing their spatial and temporal coverage, and resolution. The resulting standardized model driver data sets are being used by over 20 different models participating in MsTMIP. Lastly, the data are archived at the Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC, http://daac.ornl.gov) to provide long-term data management and distribution.« less

  14. Key regulatory drivers affecting shipments of mixed transuranic waste from Los Alamos National Laboratory to the Waste Isolation Pilot Plant

    SciTech Connect (OSTI)

    Schumann, P.B.; Bacigalupa, G.A.; Kosiewicz, S.T.; Sinkule, B.J.

    1997-02-01

    A number of key regulatory drivers affect the nature, scope, and timing of Los Alamos National Laboratory`s (LANL`s) plans for mixed transuranic (MTRU) waste shipments to the Waste Isolation Pilot Plant (WIPP), which are planned to commence as soon as possible following WIPP`s currently anticipated November, 1997 opening date. This paper provides an overview of some of the key drivers at LANL, particularly emphasizing those associated with the hazardous waste component of LANL`s MTRU waste (MTRU, like any mixed waste, contains both a radioactive and a hazardous waste component). The key drivers discussed here derive from the federal Resource Conservation and Recovery Act (RCRA) and its amendments, including the Federal Facility Compliance Act (FFCAU), and from the New Mexico Hazardous Waste Act (NMHWA). These statutory provisions are enforced through three major mechanisms: facility RCRA permits; the New Mexico Hazardous Waste Management Regulations, set forth in the New Mexico Administrative Code, Title 20, Chapter 4, Part 1: and compliance orders issued to enforce these requirements. General requirements in all three categories will apply to MTRU waste management and characterization activities at both WIPP and LANL. In addition, LANL is subject to facility-specific requirements in its RCRA hazardous waste facility permit, permit conditions as currently proposed in RCRA Part B permit applications presently being reviewed by the New Mexico Environment Department (NNED), and facility-specific compliance orders related to MTRU waste management. Likewise, permitting and compliance-related requirements specific to WIPP indirectly affect LANL`s characterization, packaging, record-keeping, and transportation requirements for MTRU waste. LANL must comply with this evolving set of regulatory requirements to begin shipments of MTRU waste to WIPP in a timely fashion.

  15. Paducah WDA CERCLA Process & Public Involvement | Department of Energy

    Energy Savers [EERE]

    CERCLA Process & Public Involvement Paducah WDA CERCLA Process & Public Involvement The CERCLA process involves stakeholder education and input throughout the life of the project. (click graphic to enlarge) The CERCLA process involves stakeholder education and input throughout the life of the project. (click graphic to enlarge) DOE is committed to fostering meaningful community involvement in environmental remediation decision making at the site. Interactive communications enable the

  16. Break-Even Cost for Residential Solar Water Heating in the United States: Key Drivers and Sensitivities

    SciTech Connect (OSTI)

    Cassard, H.; Denholm, P.; Ong, S.

    2011-02-01

    This paper examines the break-even cost for residential rooftop solar water heating (SWH) technology, defined as the point where the cost of the energy saved with a SWH system equals the cost of a conventional heating fuel purchased from the grid (either electricity or natural gas). We examine the break-even cost for the largest 1,000 electric and natural gas utilities serving residential customers in the United States as of 2008. Currently, the break-even cost of SWH in the United States varies by more than a factor of five for both electricity and natural gas, despite a much smaller variation in the amount of energy saved by the systems (a factor of approximately one and a half). The break-even price for natural gas is lower than that for electricity due to a lower fuel cost. We also consider the relationship between SWH price and solar fraction and examine the key drivers behind break-even costs. Overall, the key drivers of the break-even cost of SWH are a combination of fuel price, local incentives, and technical factors including the solar resource location, system size, and hot water draw.

  17. GC GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM...

    Energy Savers [EERE]

    GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM GC GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM The Department of Energy has on a variety of occasions ...

  18. Prototype indicators of value added through public involvement

    SciTech Connect (OSTI)

    Lach, D.; Hixson, P.; Ramonas, L.

    1995-12-01

    As more managers realize that public input in public sector decision making is a given in the current political and social climate, many are turning to public involvement as a way to manage input so that it is beneficial to their decisions and projects. Public involvement is starting to become a familiar way of doing business for many Federal agencies and its contractors. Yet, many, if not most agency and contractor managers are still unclear about the value and costs that public involvement adds to their projects. Proponents claim that public involvement increases the acceptability of project goals by increasing stakeholders` knowledge about and involvement in decisions of importance to them. In spite of these assertions avowing the benefits of public involvement, proponents have not generated methods that demonstrate or provide evidence of such value added through incorporating public involvement into projects. As these questions about the value and costs of public involvement efforts increase, there is a pressing need to document the value and costs of public involvement for the participants in these processes--the stakeholders--and to present this information to decision makers in ways that help them assess the value and costs of managing public input through a public involvement program.

  19. DOE Involvement in Consensus Negotiations for Energy Conservation Standards

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Involvement in Consensus Negotiations for Energy Conservation Standards DOE Involvement in Consensus Negotiations for Energy Conservation Standards DOE Involvement in Consensus Negotiations for Energy Conservation Standards. The Department of Energy is supportive of outside parties' negotiations efforts to reach consensus on energy conservation standards and test procedures that can be presented for consideration by the Department However, neither the Department nor

  20. On re-setting the fatigue clock on older semisubmersible vessels

    SciTech Connect (OSTI)

    Wade, B.G.

    1994-12-31

    The fatigue strength of a generic submersible, enhanced to a FPF, was determined using 1980 design regulations and compared with 1993 guidelines. The fatigue clock on this older semisubmersible was reset using advances in the fatigue assessment of weld imperfections that were not available at the time this vessel was originally designed. An inspection strategy of critical weld details was established based upon recently available crack growth data and more up-to-date fracture mechanics methods. Examples of this data include crack growth rate and threshold stress intensity factor data. Fracture mechanics analyses were performed that recognized the importance of weld imperfection shape and its evolution throughout life. Recent 3-D finite element analyses of semi-elliptical cracks located at weld toes show that crack shape and proximity of the crack front to the weld toe can significantly affect crack life.

  1. Draft Public Involvement Advice for Central Plateau Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    V0, 12914 Draft Public Involvement Advice for Central Plateau Cleanup Principles Issue managers: Pollet, Mattson, Vanni, Plahuta, Catrell Background The Tri-Party Agencies are...

  2. Tri-Party Agreement Hanford Public Involvement Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from the Comment and Response Document on the Tri-Party Agreement Hanford Public Involvement Plan The comments submitted by the Hanford Advisory Board (Advice 251) were...

  3. Tri-Party Agreement Agencies - Public involvement calendar -...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TRI-PARTY AGREEMENT AGENCIES - PUBLIC INVOLVEMENT CALENDAR - FISCAL YEAR 2015 - SEPTEMBER 2015 EVENTS IN PROGRESSCOMING SOON September 2015 October 2015 November 2015 Tri-Party...

  4. TRI-PARTY AGREEMENT HANFORD PUBLIC INVOLVEMENT PLAN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TRI-PARTY AGREEMENT HANFORD PUBLIC INVOLVEMENT PLAN (Formerly known as the Community Relations Plan) Comment and Response Document October 2012 PIP Comment and Response Document - October 2012 Page 2 Table of Contents 1.0 Introduction ...................................................................................................................................... 4 2.0 Community Involvement

  5. 10.0 COMMUNITY RELATIONS/PUBLIC INVOLVEMENT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0-1 10.0 COMMUNITY RELATIONS/PUBLIC INVOLVEMENT 10.1 INTRODUCTION This section describes, in general, the way in which the public will be involved with the implementation of this action plan. The CERCLA, as amended, requires that a community relations plan (CRP) be approved by the EPA prior to initiation of field work related to an RI/FS. The parties have agreed that the CRP is also the proper mechanism to address the public involvement process for all of the RCRA activity to be conducted

  6. Design of a 7-MV Linear Transformer Driver (LTD) for down-hole flash x-ray radiography.

    SciTech Connect (OSTI)

    Cordova, Steve Ray; Welch, Dale Robert; Oliver, Bryan Velten; Rose, David Vincent; Johnson, David Lee; Bruner, Nichelle Lee; Leckbee, Joshua J.

    2008-09-01

    Pulsed power driven flash x-ray radiography is a valuable diagnostic for subcritical experiments at the Nevada Test Site. The existing dual-axis Cygnus system produces images using a 2.25 MV electron beam diode to produce intense x-rays from a small source. Future hydrodynamic experiments will likely use objects with higher areal mass, requiring increased x-ray dose and higher voltages while maintaining small source spot size. A linear transformer driver (LTD) is a compact pulsed power technology with applications ranging from pulsed power flash x-ray radiography to high current Z-pinch accelerators. This report describes the design of a 7-MV dual-axis system that occupies the same lab space as the Cygnus accelerators. The work builds on a design proposed in a previous report [1]. This new design provides increased diode voltage from a lower impedance accelerator to improve coupling to low impedance diodes such as the self magnetic pinch (SMP) diode. The design also improves the predicted reliability by operating at a lower charge voltage and removing components that have proven vulnerable to failure. Simulations of the new design and experimental results of the 1-MV prototype are presented.

  7. Wire number dependence of the implosion dynamics, stagnation, and radiation output of tungsten wire arrays at Z driver

    SciTech Connect (OSTI)

    Mazarakis, Michael G.; Stygar, William A.; Sinars, Daniel B.; Cuneo, Michael E.; Nash, Thomas J.; Chandler, Gordon A.; Keith Matzen, M.; Porter, John L.; Struve, Kenneth W.; McDaniel, Dillon H.; Deeney, Christopher E.; Douglas, Melissa R.; Chittenden, Jerry

    2011-11-15

    We report results of the experimental campaign, which studied the initiation, implosion dynamics, and radiation yield of tungsten wire arrays as a function of the wire number. The wire array dimensions and mass were those of interest for the Z-pinch driven Inertial Confinement Fusion (ICF) program. An optimization study of the x-ray emitted peak power, rise time, and full width at half maximum was effectuated by varying the wire number while keeping the total array mass constant and equal to {approx}5.8 mg. The driver utilized was the {approx}20-MA Z accelerator before refurbishment in its usual short pulse mode of 100 ns. We studied single arrays of 20-mm diameter and 1-cm height. The smaller wire number studied was 30 and the largest 600. It appears that 600 is the highest achievable wire number with present day's technology. Radial and axial diagnostics were utilized including crystal monochromatic x-ray backlighter. An optimum wire number of {approx}375 was observed which was very close to the routinely utilized 300 for the ICF program in Sandia.

  8. Getting Involved in Manufacturing Day – College Educators Edition Webinar

    Broader source: Energy.gov [DOE]

    This webinar will help address questions on why and how community colleges, universities, and technical schools can get involved with MFG DAY.  Led by MFG DAY Co-Producers, the webinar will also...

  9. Best Practices for Emergency Response to Incidents Involving...

    Broader source: Energy.gov (indexed) [DOE]

    U.S.A. 02169-7471 E-MAIL: Foundation@NFPA.org WEB: www.nfpa.orgFoundation -- Page ... 8.2.5 Fires Involving Charging Stations 199 8.2.6 Overhaul and Recovery 199 9 ...

  10. Conceptual design for a linear-transformer driver (LTD)-based refurbishment and upgrade of the Saturn accelerator pulse-power system.

    SciTech Connect (OSTI)

    Mazarakis, Michael Gerrassimos; Struve, Kenneth William

    2006-09-01

    The purpose of this work was to develop a conceptual design for the Saturn accelerator using the modular Liner-Transformer Driver (LTD) technology to identify risks and to focus development and research for this new technology. We present a reference design for a Saturn class driver based on a number of linear inductive voltage adders connected in parallel. This design is very similar to a design reported five years ago [1]. However, with the design reported here we use 1-MA, 100-kV LTD cavities as building blocks. These cavities have already been built and are currently in operation at the HCEI in Tomsk, Russia [2]. Therefore, this new design integrates already-proven individual components into a full system design.

  11. Draft Public Involvement Advice for Central Plateau Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    V0, 12/9/14 Draft Public Involvement Advice for Central Plateau Cleanup Principles Issue managers: Pollet, Mattson, Vanni, Plahuta, Catrell Background The Tri-Party Agencies are developing principles that will guide the cleanup of Hanford's Central Plateau. The Hanford Advisory Board (HAB) believes that the broader public should be involved in the development of these principles. Hanford's Central Plateau is planned to be the final footprint of the Hanford Site. The Central Plateau contains

  12. Probative Investigation of the Thermal Stability of Wastes Involved in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    February 2014 Waste Isolation Pilot Plant (WIPP) Waste Drum Breach Event | Department of Energy Probative Investigation of the Thermal Stability of Wastes Involved in February 2014 Waste Isolation Pilot Plant (WIPP) Waste Drum Breach Event Probative Investigation of the Thermal Stability of Wastes Involved in February 2014 Waste Isolation Pilot Plant (WIPP) Waste Drum Breach Event This document was used to determine facts and conditions during the Department of Energy Accident Investigation

  13. Get Involved with Home Energy Score | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Home Energy Score » Get Involved with Home Energy Score Get Involved with Home Energy Score The Department of Energy's (DOE) Home Energy Score helps homeowners understand the energy performance of their homes and how they compare to other homes nationwide. Energy professionals and organizations can use the Score to promote energy efficiency to homeowners and encourage investments in energy improvements. Information for Homeowners Information for Interested Organizations Information for

  14. Comparison of electric and magnetic quadrupole focusing for the low energy end of an induction-linac-ICF (Inertial-Confinement-Fusion) driver

    SciTech Connect (OSTI)

    Kim, C.H.

    1987-04-01

    This report compares two physics designs of the low energy end of an induction linac-ICF driver: one using electric quadrupole focusing of many parallel beams followed by transverse combining; the other using magnetic quadrupole focusing of fewer beams without beam combining. Because of larger head-to-tail velocity spread and a consequent rapid current amplification in a magnetic focusing channel, the overall accelerator size of the design using magnetic focusing is comparable to that using electric focusing.

  15. Prospects for inertial fusion energy based on a diode-pumped solid-state laser (DPSSL) driver: Overview and development path

    SciTech Connect (OSTI)

    Orth, C.D.

    1997-03-01

    It is now known with certainty that the type of fusion known as inertial fusion will work with sufficient energy input, so inertial fusion is really beyond the ``scientific breakeven`` point in many respects. The most important question that remains for inertial fusion energy (IFE) is whether this type of fusion can operate with sufficiently low input energy to make it economically feasible for energy production. The constraint for low input energy demands operation near the inertial fusion ignition threshold, and such operation creates enormous challenges to discover a target design that will produce sufficient energy gain. There are also multiple issues relating to the scientific feasibility of using a laboratory-type ``driver`` to energize a target, such as those concerning bandwidth and beam smoothing for ``direct drive,`` and extension of hohlraum plasma physics to the IFE scale for ``indirect drive.`` One driver that appears as though it will be able to meet the IFE requirements, assuming modest development and sufficient target gain, is a diode-pumped solid-state laser (DPSSL). We give an overview of this type of laser system, and explain what development remains for the economic production of electricity using this type of driver for IFE.

  16. Community assessments: Road maps to successful public involvement

    SciTech Connect (OSTI)

    Forrest, C.J.

    1995-12-01

    This paper presents a framework for performing comprehensive community assessments to increase the effectiveness of public involvement efforts. The community assessment process involves systematic and critical examination of beliefs, attitudes, opinions and knowledge of the many groups in the community. A good community assessment gathers information on the concerns or issues directly related to an environmental project as well as other important community issues to ensure development of an effective public involvement program. The framework discusses types of people and organizations that should be included in the community assessment interview process. It also delineates steps that persons charged with performing assessments can take to ensure that the views of all potential stakeholders are included--a necessary consideration in communities that are ethnically, racially, or economically diverse. Lastly, the framework discusses types of written materials that can be analyzed for additional insight into communities. For example, it discusses methods for reviewing past issues of the local newspaper to provide both validation of the information gathered during interviews and an understanding of the ways that community members give and receive information and respond to conflict or perceived threats. This framework is designed to show environmental professionals who are responsible for public involvement how to perform an initial community assessment. It provides illustrations of instances in which information vital to a successful public involvement effort has been uncovered through a careful assessment of the community. Both the U.S. EPA and the public have made clear their intentions to require increased public involvement. Many of these efforts will succeed or fail based on how well those charged with the public involvement component of environmental projects identify community issues and design communications programs that successfully reach all stakeholders.

  17. Feasibility of developing a portable driver performance data acquisition system for human factors research: Technical tasks. Volume 1

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.; Spelt, P.F.; Schmoyer, R.L.; Kirkpatrick, J.R.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research`` was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow drive performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one (this report) addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volumes two and three present the related appendices, and the design specifications developed for DASCAR respectively. The six tasks were oriented toward: identifying parameters and measures; identifying analysis tools and methods; identifying measurement techniques and state-of-the-art hardware and software; developing design requirements and specifications; determining the cost of one or more copies of the proposed data acquisition system; and designing a development plan and constructing DASCAR. This report also covers: the background to the program; the requirements for the project; micro camera testing; heat load calculations for the DASCAR instrumentation package in automobile trunks; phase 2 of the research; the DASCAR hardware and software delivered to the National Highway Traffic Safety Administration; and crash avoidance problems that can be addressed by DASCAR.

  18. Optimizing and Diversifying the Electric Range of Plug-in Hybrid Electric Vehicles for U.S. Drivers

    SciTech Connect (OSTI)

    Lin, Zhenhong

    2012-01-01

    To provide useful information for automakers to design successful plug-in hybrid electric vehicle (PHEV) products and for energy and environmental analysts to understand the social impact of PHEVs, this paper addresses the question of how many of the U.S. consumers, if buying a PHEV, would prefer what electric ranges. The Market-oriented Optimal Range for PHEV (MOR-PHEV) model is developed to optimize the PHEV electric range for each of 36,664 sampled individuals representing U.S. new vehicle drivers. The optimization objective is the minimization of the sum of costs on battery, gasoline, electricity and refueling hassle. Assuming no battery subsidy, the empirical results suggest that: 1) the optimal PHEV electric range approximates two thirds of one s typical daily driving distance in the near term, defined as $450/kWh battery delivered price and $4/gallon gasoline price. 2) PHEVs are not ready to directly compete with HEVs at today s situation, defined by the $600/kWh battery delivered price and the $3-$4/gallon gasoline price, but can do so in the near term. 3) PHEV10s will be favored by the market over longer-range PHEVs in the near term, but longer-range PHEVs can dominate the PHEV market if gasoline prices reach as high as $5-$6 per gallon and/or battery delivered prices reach as low as $150-$300/kWh. 4) PHEVs can become much more attractive against HEVs in the near term if the electric range can be extended by only 10% with multiple charges per day, possible with improved charging infrastructure or adapted charging behavior. 5) the impact of a $100/kWh decrease in battery delivered prices on the competiveness of PHEVs against HEVs can be offset by about $1.25/gallon decrease in gasoline prices, or about 7/kWh increase in electricity prices. This also means that the impact of a $1/gallon decrease in gasoline prices can be offset by about 5/kWh decrease in electricity prices.

  19. The high current, fast, 100ns, Linear Transformer Driver (LTD) developmental project at Sandia Laboratories and HCEI.

    SciTech Connect (OSTI)

    Ward, Kevin S.; Long, Finis W.; Sinebryukhov, Vadim A. , Tomsk, Russia); Kim, Alexandre A. , Tomsk, Russia); Wakeland, Peter Eric; McKee, G. Randall; Woodworth, Joseph Ray; McDaniel, Dillon Heirman; Fowler, William E.; Mazarakis, Michael Gerrassimos; Porter, John Larry, Jr.; Struve, Kenneth William; Savage, Mark Edward; Stygar, William A.; LeChien, Keith R.; Matzen, Maurice Keith

    2010-09-01

    Sandia National Laboratories, Albuquerque, N.M., USA, in collaboration with the High Current Electronic Institute (HCEI), Tomsk, Russia, is developing a new paradigm in pulsed power technology: the Linear Transformer Driver (LTD) technology. This technological approach can provide very compact devices that can deliver very fast high current and high voltage pulses straight out of the cavity with out any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The load may be a vacuum electron diode, a z-pinch wire array, a gas puff, a liner, an isentropic compression load (ICE) to study material behavior under very high magnetic fields, or a fusion energy (IFE) target. This is because the output pulse rise time and width can be easily tailored to the specific application needs. In this paper we briefly summarize the developmental work done in Sandia and HCEI during the last few years, and describe our new MYKONOS Sandia High Current LTD Laboratory. An extensive evaluation of the LTD technology is being performed at SNL and the High Current Electronic Institute (HCEI) in Tomsk Russia. Two types of High Current LTD cavities (LTD I-II, and 1-MA LTD) were constructed and tested individually and in a voltage adder configuration (1-MA cavity only). All cavities performed remarkably well and the experimental results are in full agreement with analytical and numerical calculation predictions. A two-cavity voltage adder is been assembled and currently undergoes evaluation. This is the first step towards the completion of the 10-cavity, 1-TW module. This MYKONOS voltage adder will be the first ever IVA built with a transmission line insulated with deionized water. The LTD II cavity renamed LTD III will serve as a test bed for evaluating a number of different types of switches, resistors, alternative capacitor configurations, cores

  20. Free Legal Services - Attracting Legal Talent for Public Involvement Groups

    SciTech Connect (OSTI)

    Domby, A.H.

    2007-07-01

    This paper reviews the public service responsibilities of lawyers, and how they can fulfill the annual goal of performing pro bono services by serving certain public involvement groups, including organization involved in Constitutional issues and environmental protection matters. Public involvement groups should consider their needs for legal services and consider soliciting lawyers to serve on their boards or to volunteer legal services which will assist those lawyers in fulfilling their professional obligations under Rules of Professional Conduct. The group should identify specific activities and tasks that require the skills and training of a lawyer, including corporate governance issues; conflict-of-interest questions; the statutory construction of laws, regulations and ordinances; or analysis of potential liability. The addition of a lawyer to advisory boards for governmental agencies and for non-profit boards of charitable, religious, civic, community, environmental and educational organizations may provide those boards with knowledge, analytical approaches and insights that complement the abilities of other board members. Rules of Professional Conduct applicable to lawyers include admonitions for lawyers to provide 'Public Service'. Representative of many rules, the American Bar Association Model Rule 6.1, entitled 'Voluntary Pro Bono Publico Service' addresses every lawyer's professional responsibility to provide legal services to those 'unable to pay'. This Model Rule exhorts each lawyer to provide fifty (50) hours of legal services without fee or expectation of fee to persons of limited means or charitable, religious or civic, community, governmental and educational organizations or to individuals, groups or organizations seeking 'to secure or protect civil rights, civil liberties, or public rights, or charitable, religious, civic, community, governmental and educational organizations in matters in furtherance of their purposes, where the payment of

  1. Differential capacitance probe for process control involving aqueous dielectric fluids

    DOE Patents [OSTI]

    Svoboda, John M.; Morrison, John L.

    2002-10-08

    A differential capacitance probe device for process control involving aqueous dielectric fluids is disclosed. The device contains a pair of matched capacitor probes configured in parallel, one immersed in a sealed container of reference fluid, and the other immersed in the process fluid. The sealed container holding the reference fluid is also immersed in the process fluid, hence both probes are operated at the same temperature. Signal conditioning measures the difference in capacitance between the reference probe and the process probe. The resulting signal is a control error signal that can be used to control the process.

  2. Tri-Party Agreement Agencies Annual Hanford Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7 Tri-Party Agreement Agencies Annual Hanford Public Involvement Survey 1. How do you usually receive information about Hanford topics? (Please select all that apply) Response Percent Response Count Advisory Board 23.7% 22 Citizens Group 32.3% 30 Ecology website 21.5% 20 Hanford.gov website 33.3% 31 Hanford Listserv (email) 54.8% 51 Hanford Mailing (postal) 12.9% 12 Newspaper 48.4% 45 Radio 26.9% 25 Social Media (Facebook, Twitter, etc.) 26.9% 25 Television 17.2% 16 Work Announcements 11.8% 11 I

  3. Antitrust aspects of involvement by utilities in residential solar energy

    SciTech Connect (OSTI)

    Hurst, T.R.

    1983-01-01

    A utility that merely engages in the sale of solar units produced by independent manufacturers on a nonexclusive basis appears to run little risk of violating federal antitrust laws, but virtually every other unregulated activity would involve enough significant exposure to antitrust liability to preclude a prudent utility from engaging in them on any basis other than one where the state-action exemption clearly shields the utility. The case cited in this review indicates that municipal utilities must be equally cautious when engaging in pro-solar activities that may have an anticompetitive impact on various parties who could become plaintiffs in a private antitrust action. 47 references.

  4. Central Plateau Principles Public Involvement Advice DETAILED BACKGROUND

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    v0, 12/9/14 Central Plateau Principles Public Involvement Advice DETAILED BACKGROUND Cleanup of Hanford's Central Plateau is expected to take another four decades or longer, and cost tens of billions of dollars. The Central Plateau includes the 200 East and 200 West Areas with all of Hanford's High-Level Nuclear Waste Tank Farms, processing plants, sites where over a million gallons of High-Level Nuclear Waste has leaked from Single Shell Tanks (SSTs), and billions of gallons of waste was

  5. Standard Electrode Potentials Involving Radicals in Aqueous Solution: Inorganic Radicals

    SciTech Connect (OSTI)

    Armstrong, David A.; Huie, Robert E.; Koppenol, Willem H.; Lymar, Sergei V.; Merenyi, Gabor; Neta, Pedatsur; Ruscic, Branko; Stanbury, David M.; Steenken, Steen; Wardman, Peter

    2015-12-01

    Recommendations are made for standard potentials involving select inorganic radicals in aqueous solution at 25 °C. These recommendations are based on a critical and thorough literature review and also by performing derivations from various literature reports. The recommended data are summarized in tables of standard potentials, Gibbs energies of formation, radical pKa’s, and hemicolligation equilibrium constants. In all cases, current best estimates of the uncertainties are provided. An extensive set of Data Sheets is appended that provide original literature references, summarize the experimental results, and describe the decisions and procedures leading to each of the recommendations

  6. Quantitative understanding of Forbush decrease drivers based on shock-only and CME-only models using global signature of February 14, 1978 event

    SciTech Connect (OSTI)

    Raghav, Anil; Lotekar, Ajay; Bhaskar, Ankush; Vichare, Geeta; Yadav, Virendra E-mail: ankushbhaskar@gmail.com E-mail: vicharegeeta@gmail.com

    2014-10-01

    We have studied the Forbush decrease (FD) event that occurred on February 14, 1978 using 43 neutron monitor observatories to understand the global signature of FD. We have studied rigidity dependence of shock amplitude and total FD amplitude. We have found almost the same power law index for both shock phase amplitude and total FD amplitude. Local time variation of shock phase amplitude and maximum depression time of FD have been investigated which indicate possible effect of shock/CME orientation. We have analyzed rigidity dependence of time constants of two phase recovery. Time constants of slow component of recovery phase show rigidity dependence and imply possible effect of diffusion. Solar wind speed was observed to be well correlated with slow component of FD recovery phase. This indicates solar wind speed as possible driver of recovery phase. To investigate the contribution of interplanetary drivers, shock and CME in FD, we have used shock-only and CME-only models. We have applied these models separately to shock phase and main phase amplitudes respectively. This confirms presently accepted physical scenario that the first step of FD is due to propagating shock barrier and second step is due to flux rope of CME/magnetic cloud.

  7. Fact #922: April 25, 2016 Share of Older Population Holding Driver’s Licenses is Up and Share of Younger Population Holding Driver’s Licenses is Down- Dataset

    Broader source: Energy.gov [DOE]

    Excel file and dataset for Share of Older Population Holding Driver’s Licenses is Up and Share of Younger Population Holding Driver’s Licenses is Down

  8. Market power and foreign involvement by US multinationals

    SciTech Connect (OSTI)

    Hirschey, M.

    1982-05-01

    This study considers the relationship between market power and multinational involvement through use of a market-valuation approach. Estimation results for a sample of large US multinationals reveal superior valuation effects due to returns from foreign as opposed to domestic operations. This finding is consistent with the hypothesis that returns from the US market tend to be less secure, and therefore less valued, than are returns from foreign markets due to both real (market size, entry barriers, etc.) and institutional (antitrust policies, etc.) differences in competitive environments. Such findings are also consistent with previous suggestions that firms develop markets abroad in order to exploit economic-rent opportunities. These findings remain tentative, however, and await verification in future studies of data from both the United States and abroad. 13 references, 1 table.

  9. Development of Patients' Decision Aid for Older Women With Stage I Breast Cancer Considering Radiotherapy After Lumpectomy

    SciTech Connect (OSTI)

    Wong, Jennifer; D'Alimonte, Laura; Angus, Jan; Paszat, Larry; Metcalfe, Kelly; Whelan, Tim; Llewellyn-Thomas, Hilary; Warner, Eiran; Franssen, Edmee; Szumacher, Ewa

    2012-09-01

    Purpose: To develop a patient decision aid (PtDA) for older women with Stage I, pathologically node negative, estrogen receptor-positive progesterone receptor-positive breast cancer who are considering adjuvant radiotherapy after lumpectomy and to examine its impact on patients' decision making. Methods and Materials: A PtDA was developed and evaluated in three steps according to the Ottawa Decision Support Framework: (1) needs assessment (n = 16); (2) Pilot I to examine PtDA acceptability (n = 12); and (3) Pilot II, a pretest posttest (n = 38) with older women with estrogen receptor-positive progesterone receptor-positive breast cancer after lumpectomy who were receiving adjuvant radiation therapy. Measures included patients' satisfaction with the PtDA, self-reported decisional conflict, level of distress, treatment-related knowledge, and choice predisposition. Results: The PtDA is a booklet that details each adjuvant treatment option's benefits, risks, and side effects tailored to the patient's clinical profile; includes a values clarification exercise; and includes steps to guide patients towards their decision. On the basis of qualitative comments and satisfaction ratings, all women thought that the PtDA was helpful and informative. In comparison with their baseline scores, patients had a statistically significant (p < 0.05) reduction in decisional conflict (adjusted mean difference [AMD], -7.18; 95% confidence interval [CI], -13.50 to 12.59); increased clarity of the benefits and risks (AMD, -10.86; CI, -20.33 to 21.49); and improved general treatment knowledge (AMD, 8.99; CI, 2.88-10.28) after using the PtDA. General trends were also reported in the patients' choice predisposition scores that suggested potential differences in treatment decision after PtDA use. Conclusions: This study provides evidence that this PtDA may be a helpful educational tool for this group of women. The quality of care for older breast cancer patients may be enhanced by the use of a

  10. Land-use transition for bioenergy and climate stabilization: model comparison of drivers, impacts and interactions with other land use based mitigation options

    SciTech Connect (OSTI)

    Popp, Alexander; Rose, Steven K.; Calvin, Katherine V.; Van Vuuren, Detlef; Dietrich, Jan P.; Wise, Marshall A.; Stehfest, Eike; Humpenoder, Florian; Kyle, G. Page; Van Vliet, Jasper; Bauer, Nico; Lotze-Campen, Hermann; Klein, David; Kriegler, Elmar

    2014-04-01

    This study is a model comparison assessing the drivers and impacts of bioenergy production on the global land system and the interaction with other land use based mitigation options in the context of the EMF 27 project. We compare and evaluate results from three integrated assessment models (GCAM, IMAGE, and ReMIND/MAgPIE). All three models project that dedicated bioenergy crops and biomass residues are a potentially important and cost-effective component of the energy system. But bioenergy deployment levels and feedstock composition vary notably across models as do the implications for land-use and greenhouse gas emissions and the interaction with other land use based mitigation measures. Despite numerous model differences, we identify a few that are likely contributing to differences in land-use and emissions attributable to energy crop deployment.

  11. Parametic Study of the current limit within a single driver-scaletransport beam line of an induction Linac for Heavy Ion Fusion

    SciTech Connect (OSTI)

    Prost, Lionel Robert

    2007-02-14

    The High Current Experiment (HCX) at Lawrence Berkeley National Laboratory is part of the US program that explores heavy-ion beam as the driver option for fusion energy production in an Inertial Fusion Energy (IFE) plant. The HCX is a beam transport experiment at a scale representative of the low-energy end of an induction linear accelerator driver. The primary mission of this experiment is to investigate aperture fill factors acceptable for the transport of space-charge-dominated heavy-ion beams at high intensity (line charge density {approx}0.2 {micro}C/m) over long pulse durations (4 {micro}s) in alternating gradient focusing lattices of electrostatic or magnetic quadrupoles. This experiment is testing transport issues resulting from nonlinear space-charge effects and collective modes, beam centroid alignment and steering, envelope matching, image charges and focusing field nonlinearities, halo and, electron and gas cloud effects. We present the results for a coasting 1 MeV K{sup +} ion beam transported through ten electrostatic quadrupoles. The measurements cover two different fill factor studies (60% and 80% of the clear aperture radius) for which the transverse phase-space of the beam was characterized in detail, along with beam energy measurements and the first halo measurements. Electrostatic quadrupole transport at high beam fill factor ({approx}80%) is achieved with acceptable emittance growth and beam loss. We achieved good envelope control, and re-matching may only be needed every ten lattice periods (at 80% fill factor) in a longer lattice of similar design. We also show that understanding and controlling the time dependence of the envelope parameters is critical to achieving high fill factors, notably because of the injector and matching section dynamics.

  12. Representation of analysis results involving aleatory and epistemic uncertainty.

    SciTech Connect (OSTI)

    Johnson, Jay Dean; Helton, Jon Craig; Oberkampf, William Louis; Sallaberry, Cedric J.

    2008-08-01

    Procedures are described for the representation of results in analyses that involve both aleatory uncertainty and epistemic uncertainty, with aleatory uncertainty deriving from an inherent randomness in the behavior of the system under study and epistemic uncertainty deriving from a lack of knowledge about the appropriate values to use for quantities that are assumed to have fixed but poorly known values in the context of a specific study. Aleatory uncertainty is usually represented with probability and leads to cumulative distribution functions (CDFs) or complementary cumulative distribution functions (CCDFs) for analysis results of interest. Several mathematical structures are available for the representation of epistemic uncertainty, including interval analysis, possibility theory, evidence theory and probability theory. In the presence of epistemic uncertainty, there is not a single CDF or CCDF for a given analysis result. Rather, there is a family of CDFs and a corresponding family of CCDFs that derive from epistemic uncertainty and have an uncertainty structure that derives from the particular uncertainty structure (i.e., interval analysis, possibility theory, evidence theory, probability theory) used to represent epistemic uncertainty. Graphical formats for the representation of epistemic uncertainty in families of CDFs and CCDFs are investigated and presented for the indicated characterizations of epistemic uncertainty.

  13. Personnel involved in nuclear standards development: 1980 directory

    SciTech Connect (OSTI)

    Carr, S.J.

    1980-03-01

    The development of nuclear standards is an active and necessary endeavor that is concerned with the safe, orderly, and economic development of nuclear potential. There are almost 4100 people from the teachnical community who are presently involved either in writing nuclear standards, including codes, or in the management and processing roles necessary for their approval and promulgation. This document identifies the current participation of each individual as member, chairman, cochairman (vice-chairman), or secretary of about 700 standards development committees and groups. The standards committees and groups are identified with the organizations that are responsible for the preparation, review, and maintenance of the standards and that provide support through supervisory committees and headquarters staff. This directory includes four major sections: personnel, employers, committees, and a Key-Word-in-Context (KWIC) Index of committee titles. It can also be used to identify the participation of employers as well as to recognize the contributions of individuals to the often interdisciplinary activity of standards development.

  14. Surface interactions involved in flashover with high density electronegative gases.

    SciTech Connect (OSTI)

    Hodge, Keith Conquest; Warne, Larry Kevin; Jorgenson, Roy Eberhardt; Wallace, Zachariah Red; Lehr, Jane Marie

    2010-01-01

    This report examines the interactions involved with flashover along a surface in high density electronegative gases. The focus is on fast ionization processes rather than the later time ionic drift or thermalization of the discharge. A kinetic simulation of the gas and surface is used to examine electron multiplication and includes gas collision, excitation and ionization, and attachment processes, gas photoionization and surface photoemission processes, as well as surface attachment. These rates are then used in a 1.5D fluid ionization wave (streamer) model to study streamer propagation with and without the surface in air and in SF6. The 1.5D model therefore includes rates for all these processes. To get a better estimate for the behavior of the radius we have studied radial expansion of the streamer in air and in SF6. The focus of the modeling is on voltage and field level changes (with and without a surface) rather than secondary effects, such as, velocities or changes in discharge path. An experiment has been set up to carry out measurements of threshold voltages, streamer velocities, and other discharge characteristics. This setup includes both electrical and photographic diagnostics (streak and framing cameras). We have observed little change in critical field levels (where avalanche multiplication sets in) in the gas alone versus with the surface. Comparisons between model calculations and experimental measurements are in agreement with this. We have examined streamer sustaining fields (field which maintains ionization wave propagation) in the gas and on the surface. Agreement of the gas levels with available literature is good and agreement between experiment and calculation is good also. Model calculations do not indicate much difference between the gas alone versus the surface levels. Experiments have identified differences in velocity between streamers on the surface and in the gas alone (the surface values being larger).

  15. Classroom simulation of public involvement in H.L.W. issues featuring STS concepts

    SciTech Connect (OSTI)

    Bieniawski, Z.T.

    1996-12-01

    This paper reports on a classroom experiment, now in its third year, conducted by the author for students involvement in High-Level Waste disposal. The project involved designing a methodology for HLW management in the United States.

  16. Discovery of a new ATP-binding motif involved in peptidic azoline...

    Office of Scientific and Technical Information (OSTI)

    Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis Citation Details In-Document Search Title: Discovery of a new ATP-binding motif involved in peptidic ...

  17. Influence of microwave driver coupling design on plasma density at Testbench for Ion sources Plasma Studies, a 2.45 GHz Electron Cyclotron Resonance Plasma Reactor

    SciTech Connect (OSTI)

    Mega-Macas, A.; Vizcano-de-Julin, A.; Cortzar, O. D.

    2014-03-15

    A comparative study of two microwave driver systems (preliminary and optimized) for a 2.45 GHz hydrogen Electron Cyclotron Resonance plasma generator has been conducted. The influence on plasma behavior and parameters of stationary electric field distribution in vacuum, i.e., just before breakdown, along all the microwave excitation system is analyzed. 3D simulations of resonant stationary electric field distributions, 2D simulations of external magnetic field mapping, experimental measurements of incoming and reflected power, and electron temperature and density along the plasma chamber axis have been carried out. By using these tools, an optimized set of plasma chamber and microwave coupler has been designed paying special attention to the optimization of stationary electric field value in the center of the plasma chamber. This system shows a strong stability on plasma behavior allowing a wider range of operational parameters and even sustaining low density plasma formation without external magnetic field. In addition, the optimized system shows the capability to produce values of plasma density four times higher than the preliminary as a consequence of a deeper penetration of the magnetic resonance surface in relative high electric field zone by keeping plasma stability. The increment of the amount of resonance surface embedded in the plasma under high electric field is suggested as a key factor.

  18. Getting Involved

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    received help navigating the draft EIS and asked questions about the project, the EIS process, documentation and how to submit comments on the document. There were no formal...

  19. Customer Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Projects Expand Projects Skip navigation links Ancillary and Control Area Services (ACS) Practices Forum Meetings Customer Comments Attachment K 2015 Planning Cycle 2014...

  20. Involvement & Outreach

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Volunteers - Sign Up About Science Bowl Curriculum and Activities How to Build a Motor The Great Marble Drop How to Build a Turbine How to Build a Tower Classroom...

  1. Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

    SciTech Connect (OSTI)

    Diaz, Dolores; Ford, Kevin A.; Hartley, Dylan P.; Harstad, Eric B.; Cain, Gary R.; Achilles-Poon, Kirsten; Nguyen, Trung; Peng, Jing; Zheng, Zhong; Merchant, Mark; Sutherlin, Daniel P.; Gaudino, John J.; Kaus, Robert; Lewin-Koh, Sock C.; Choo, Edna F.; Liederer, Bianca M.; Dambach, Donna M.

    2013-01-01

    Several toxicities are clearly driven by free drug concentrations in plasma, such as toxicities related to on-target exaggerated pharmacology or off-target pharmacological activity associated with receptors, enzymes or ion channels. However, there are examples in which organ toxicities appear to correlate better with total drug concentrations in the target tissues, rather than with free drug concentrations in plasma. Here we present a case study in which a small molecule Met inhibitor, GEN-203, with significant liver and bone marrow toxicity in preclinical species was modified with the intention of increasing the safety margin. GEN-203 is a lipophilic weak base as demonstrated by its physicochemical and structural properties: high LogD (distribution coefficient) (4.3) and high measured pKa (7.45) due to the basic amine (N-ethyl-3-fluoro-4-aminopiperidine). The physicochemical properties of GEN-203 were hypothesized to drive the high distribution of this compound to tissues as evidenced by a moderately-high volume of distribution (Vd > 3 l/kg) in mouse and subsequent toxicities of the compound. Specifically, the basicity of GEN-203 was decreased through addition of a second fluorine in the 3-position of the aminopiperidine to yield GEN-890 (N-ethyl-3,3-difluoro-4-aminopiperidine), which decreased the volume of distribution of the compound in mouse (Vd = 1.0 l/kg), decreased its tissue drug concentrations and led to decreased toxicity in mice. This strategy suggests that when toxicity is driven by tissue drug concentrations, optimization of the physicochemical parameters that drive tissue distribution can result in decreased drug concentrations in tissues, resulting in lower toxicity and improved safety margins. -- Highlights: ? Lower pKa for a small molecule: reduced tissue drug levels and toxicity. ? New analysis tools to assess electrostatic effects and ionization are presented. ? Chemical and PK drivers of toxicity can be leveraged to improve safety.

  2. 01-12-1998 - Bench Top FIre Involving Use of Alcohol and Burner...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1998 - Bench Top FIre Involving Use of Alcohol and Burner Document Number: NA Effective Date: 011998 File (public): PDF icon 01-12-1998...

  3. Regulatory Drivers | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Custody and Long-Term Care of Uranium or Thorium Byproduct Materials Disposal Sites," 10 ... Protection Standards for Uranium and Thorium Mill Tailings," 40 CFR 192 "Uranium Mill ...

  4. P5 Science Drivers: Theory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    means to extract SM parameters depending on non-perturbative dynamics of QCD Ab-initio calculation in discrete space-time with lattice spacings down to 0.06 fm in 144 3 ...

  5. Oil market outlook and drivers

    Gasoline and Diesel Fuel Update (EIA)

    Oil inventories in industrialized countries to reach record high at end of 2015 The amount of year-end oil inventories held in industrialized countries is expected to be the highest on record in 2015. In its monthly forecast, the U.S. Energy Information Administration said it expects commercial oil inventories in the United States and other industrialized countries to total 2.83 billion barrels at the end of this year almost 90 million barrels more than at the end of 2014. Global oil production

  6. Community Engagement as a Driver

    Broader source: Energy.gov [DOE]

    Presents the outreach approaches used by New Jersey's Clean Energy Program, as well as the lessons learned from various types of leads.

  7. Breast Cancer Patients With 10 or More Involved Axillary Lymph Nodes Treated by Multimodality Therapy: Influence of Clinical Presentation on Outcome

    SciTech Connect (OSTI)

    Geara, Fady B. . E-mail: fg00@aub.edu.lb; Nasr, Elie; Tucker, Susan L.; Charafeddine, Maya; Dabaja, Bouthaina; Eid, Toufic; Abbas, Jaber; Salem, Ziad; Shamseddine, Ali; Issa, Philip; El Saghir, Nagi

    2007-06-01

    Purpose: To analyze tumor control and survival for breast cancer patients with 10 or more positive lymph nodes without systemic disease, treated by adjuvant radiation alone or combined-modality therapy. Methods and Materials: We reviewed the records of 309 consecutive patients with these characteristics who received locoregional radiotherapy (RT) at our institution. The majority of patients had clinical Stage II or IIIA-B disease (43% and 48%, respectively). The median number of positive axillary lymph nodes was 15 (range, 10-78). Adjuvant therapy consisted of RT alone, with or without chemotherapy, tamoxifen, and/or ovarian castration. Results: The overall 5-year and 10-year disease-free survival (DFS) rates were 20% and 7%, respectively. Median DFS was higher for patients with Stage I-II compared with those with Stage IIIABC (28 vs. 19 months; p = 0.006). Median DFS for patients aged {<=}35 years was lower than that of older patients (12 vs. 24 months; p < 0.0001). Patients treated with a combination therapy had a higher 5-year DFS rate compared with those treated by RT alone (26% vs. 11%; p 0.03). In multivariate analysis, clinical stage (III vs. I, II; relative risk = 1.8, p = 0.002) and age ({<=}35 vs. others; relative risk = 2.6, p <0.001) were found to be independent variables for DFS. Conclusion: This retrospective data analysis identified young age and advanced clinical stage as pertinent and independent clinical prognostic factors for breast cancer patients with advanced axillary disease (10 or more involved nodes). These factors can be used for further prognostic classification.

  8. Public involvement in the regulatory activities regarding nuclear fuel cycle facilities: A case study

    SciTech Connect (OSTI)

    Austin, D.E.

    1995-12-01

    This paper reviews the involvement of a community-based organization in the activities of the Nuclear Regulatory Commission (NRC) regarding a uranium conversion facility that operated near Gore, Oklahoma from 1970 until 1992. Effective participation requires access to decision making. Access is a complex phenomenon that includes: (1) opportunity, both procedural and physical, (2) a common language, and (3) time and resources. The paper describes how both the community organization and the NRC responded to these requirements for access, the strategies that were most effective in securing meaningful public involvement in the decision making, and the impacts of that involvement on the organization.

  9. Molecular genetic analysis of activation-tagged transcription factors thought to be involved in photomorphogenesis

    SciTech Connect (OSTI)

    Neff, Michael M.

    2011-06-23

    This is a final report for Department of Energy Grant No. DE-FG02-08ER15927 entitled “Molecular Genetic Analysis of Activation-Tagged Transcription Factors Thought to be Involved in Photomorphogenesis”. Based on our preliminary photobiological and genetic analysis of the sob1-D mutant, we hypothesized that OBP3 is a transcription factor involved in both phytochrome and cryptochrome-mediated signal transduction. In addition, we hypothesized that OBP3 is involved in auxin signaling and root development. Based on our preliminary photobiological and genetic analysis of the sob2-D mutant, we also hypothesized that a related gene, LEP, is involved in hormone signaling and seedling development.

  10. 01-12-1998 - Bench Top FIre Involving Use of Alcohol and Burner | The Ames

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory 1998 - Bench Top FIre Involving Use of Alcohol and Burner Document Number: NA Effective Date: 01/1998 File (public): PDF icon 01-12-1998

  11. Conflict-of-Interest/Non-Disclosure Certificate For Reviewers Involved in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Selection of Subcontractors for NEUP Research and Development Funds | Department of Energy Conflict-of-Interest/Non-Disclosure Certificate For Reviewers Involved in the Selection of Subcontractors for NEUP Research and Development Funds Conflict-of-Interest/Non-Disclosure Certificate For Reviewers Involved in the Selection of Subcontractors for NEUP Research and Development Funds The Department of Energy has a policy that individuals with a conflict of interest cannot participate in the

  12. Public Understanding of Cleanup Levels Discussion Public Involvement Committee Meeting - Hanford Advisory Board

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Discussion Public Involvement Committee Meeting - Hanford Advisory Board Wednesday, October 31, 2012 - Red Lion Hanford House, Richland Page 1 of 4 Cleanup Levels One of the reasons we want public involvement on cleanup decisions is to gather input about what kind of cleanup end-state the public wants, how clean is clean, or put another way, how dirty is acceptable. Cleanup decisions are complicated. Cleanup levels necessary to be protective dictate which cleanup actions are viable to consider.

  13. The Community Environmental Monitoring Program: Reducing Public Perception of Risk through Stakeholder Involvement

    SciTech Connect (OSTI)

    William T. Hartwell

    2007-05-21

    The Community Environmental Monitoring Program (CEMP) has promoted stakeholder involvement, awareness, and understanding of radiological surveillance in communities surrounding the Nevada Test Site (NTS) since 1981. It involves stakeholders in the operation, data collection, and dissemination of information obtained from a network of 29 stations across a wide area of Nevada, Utah and California. It is sponsored by the U.S. Department of Energy, National Nuclear Security Administration’s Nevada Site Office (NNSA/NSO) and administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. Integration of a near real-time communications system, a public web site, training workshops for involved stakeholders, and educational programs all help to alleviate public perception of risk of health effects from past activities conducted at the NTS.

  14. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect (OSTI)

    United States. Bonneville Power Administration.

    1994-01-01

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  15. Getting the lead out: Citizen involvement in the Williamsburg Bridge lead paint removal project

    SciTech Connect (OSTI)

    Forker, T.R.

    1997-08-01

    This paper examines the process and results of citizen involvement in developing new environmental control and compliance procedures used by the New York City Department of Transportation (NYC DOT) for lead paint removal on the Williamsburg Bridge and other structures. As a case study of the effects of public involvement in environmental decision-making, the study identifies and discusses the factors that produced failures or successes in satisfying the citizen`s concerns about health risks and the effectiveness of the selected pollution control technology.

  16. Differing Professional Opinions Manual for Technical Issues Involving Environment, Safety, and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-11-16

    This Manual establishes a differing professional opinion (DPO) policy to a Department of Energy (DOE) Differing Professional Opinion (DPO) Process to encourage and facilitate dialogue and resolution on DPOs from employees for technical issues involving environment, safety, and health. Does not cancel other directives. Canceled by DOE O 442.2.

  17. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county`s future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  18. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  19. The people problems of NEPA: Social impact assessment and the role of public involvement

    SciTech Connect (OSTI)

    Carnes, S.A.

    1989-12-31

    This Chapter of the book `` The Scientific Challenges of NEPA`` discusses the people problems of NEPA and social impact assessment and the role of public involvement in NEPA. When Congress passed the National Environmental Policy Act (NEPA) in 1969, there was little guidance on the preparation of environmental impact statements (EIS) and the role of the public in the NEPA process. Excepting the statutory language of NEPA, which referred to impacts on the human environment, nowhere was this more evident than with respect to people. Questions such as what impacts on people should be assessed, how impacts on people should be assessed, and how people, including but not limited to those persons potentially impacted, should be involved in the assessment itself as well as NEPA`s associated administrative processes, were simply not addressed.

  20. A statistical description of the types and severities of accidents involving tractor semi-trailers

    SciTech Connect (OSTI)

    Clauss, D.B.; Wilson, R.K.; Blower, D.F.; Campbell, K.L.

    1994-06-01

    This report provides a statistical description of the types and severities of tractor semi-trailer accidents involving at least one fatality. The data were developed for use in risk assessments of hazardous materials transportation. Several accident databases were reviewed to determine their suitability to the task. The TIFA (Trucks Involved in Fatal Accidents) database created at the University of Michigan Transportation Research Institute was extensively utilized. Supplementary data on collision and fire severity, which was not available in the TIFA database, were obtained by reviewing police reports for selected TIFA accidents. The results are described in terms of frequencies of different accident types and cumulative distribution functions for the peak contact velocity, rollover skid distance, fire temperature, fire size, fire separation, and fire duration.

  1. The value of adding regional to local stakeholder involvement in evaluating the acceptability of innovative technologies

    SciTech Connect (OSTI)

    Peterson, T.; McCabe, G.; Niesen, K.; Patricia, S.

    1995-12-01

    Technology is urgently needed to clean up contamination by volatile organic compounds at United States Department of Energy (DOE) and industrial sites throughout the country. In many cases, however, existing technology is too slow, inefficient, or expensive. The record of technology development is similarly disappointing. Remediation technologies developed at great expense and evaluated piecemeal over long periods have not been deployed because, in the end, the public judged them ineffective or unacceptable. The need for remediation is too great and resources too limited to continue with ineffective technology evaluation. Early and continuing stakeholder involvement is essential to developing successful, deployable technologies. In order to make good decisions about which technologies to deploy, remedial project managers need to know stakeholders` requirements for the performance of proposed technologies. Expanding stakeholder involvement regionally identifies the concerns of a broad range of stakeholders at a arid DOE sites throughout the West - issues that must be taken into account if technologies are to be accepted for wide deployment.

  2. Creating an Ethical Framework for Studies That Involve the Worker Community

    Office of Science (SC) Website

    | U.S. DOE Office of Science (SC) DOE Resources » Creating an Ethical Framework for Studies That Involve the Worker Community Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources CITI Courses DOE Resources Ethical Framework Informed Consent Special Research Categories Community IRB Member Resources Other Resources Human Subjects Research Database (HSRD) IRB7 Regulations and Requirements Glossary Abbreviations Contact BER Home

  3. Temperature of aircraft cargo flame exposure during accidents involving fuel spills

    SciTech Connect (OSTI)

    Mansfield, J.A.

    1993-01-01

    This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

  4. LANL gets young women involved in math and science at 31st Expanding Your

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Horizons Conference April 6 31st Expanding Your Horizons Conference LANL gets young women involved in math and science at 31st Expanding Your Horizons Conference April 6 The young women will participate in hands-on activities in such fields as astronomy, robotics, forensics, chemistry, and earth science. March 4, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering

  5. Quality control procedures for dynamic treatment delivery techniques involving couch motion

    SciTech Connect (OSTI)

    Yu, Victoria Y.; Fahimian, Benjamin P.; Xing, Lei; Hristov, Dimitre H.

    2014-08-15

    In this study, the authors introduce and demonstrate quality control procedures for evaluating the geometric and dosimetric fidelity of dynamic treatment delivery techniques involving treatment couch motion synchronous with gantry and multileaf collimator (MLC). Tests were designed to evaluate positional accuracy, velocity constancy and accuracy for dynamic couch motion under a realistic weight load. A test evaluating the geometric accuracy of the system in delivering treatments over complex dynamic trajectories was also devised. Custom XML scripts that control the Varian TrueBeam STx (Serial #3) axes in Developer Mode were written to implement the delivery sequences for the tests. Delivered dose patterns were captured with radiographic film or the electronic portal imaging device. The couch translational accuracy in dynamic treatment mode was 0.01 cm. Rotational accuracy was within 0.3, with 0.04 cm displacement of the rotational axis. Dose intensity profiles capturing the velocity constancy and accuracy for translations and rotation exhibited standard deviation and maximum deviations below 3%. For complex delivery involving MLC and couch motions, the overall translational accuracy for reproducing programmed patterns was within 0.06 cm. The authors conclude that in Developer Mode, TrueBeam is capable of delivering dynamic treatment delivery techniques involving couch motion with good geometric and dosimetric fidelity.

  6. ABSTRACT: The Community Environmental Monitoring Program: Reducing Public Perception of Risk Through Stakeholder Involvement

    SciTech Connect (OSTI)

    T. Hartwell

    2007-02-28

    Between 1951 and 1992, 928 nuclear tests were conducted at the Nevada Test Site (NTS), including 100 atmospheric and 828 underground tests. Initial public reaction to the tests was largely supportive, but by the late 1950s this began to change, largely as a result of fear of the potential for adverse health effects to be caused by exposure to ionizing radiation resulting from the tests. The nuclear power plant accident at Three Mile Island in 1979 served to heighten these fears, as well as foster a general distrust of the federal agencies involved and low public confidence in monitoring results. Modeled after a similar program that involved the public in monitoring activities around the Three Mile Island nuclear power plant, the Community Environmental Monitoring Program (CEMP) has promoted stakeholder involvement, awareness, and understanding of radiological surveillance in communities surrounding the NTS since 1981. It involves stakeholders in the operation, data collection, and dissemination of information obtained from a network of 29 stations across a wide area of Nevada, Utah, and California. It is sponsored by the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) and administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. Since assuming administration of the program in 2000, DRI has accomplished significant enhancements to the network's data collection and transmission capabilities. A robust datalogging and communications system allows for the near real-time transmission of data to a platform maintained by DRI's Western Regional Climate Center, where the data are uploaded and displayed on a publicly accessible web site (http://cemp.dri.edu/). Additionally, the CEMP can serve as part of an emergency response network in the event of an unplanned radiological release from the NTS, and also provides an excellent platform for testing new environmental sensor technologies

  7. Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation. Final report

    SciTech Connect (OSTI)

    Baulch, Janet

    2013-09-11

    This is a 'glue grant' that was part of a DOE Low Dose project entitled 'Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation'. This collaborative program has involved Drs. David L. Springer from Pacific Northwest National Laboratory (PNNL), John H. Miller from Washington State University, Tri-cities (WSU) and William F. Morgan then from the University of Maryland, Baltimore (UMB). In July 2008, Dr. Morgan moved to PNNL and Dr. Janet E. Baulch became PI for this project at University of Maryland. In November of 2008, a one year extension with no new funds was requested to complete the proteomic analyses. The project stemmed from studies in the Morgan laboratory demonstrating that genomically unstable cells secret a soluble factor or factors into the culture medium, that cause cytogenetic aberrations and apoptosis in normal parental GM10115 cells. The purpose of this project was to identify the death inducing effect (DIE) factor or factors, estimate their relative abundance, identify the cell signaling pathways involved and finally recapitulate DIE in normal cells by exogenous manipulation of putative DIE factors in culture medium. As reported in detail in the previous progress report, analysis of culture medium from the parental cell line, and stable and unstable clones demonstrated inconsistent proteomic profiles as relate to candidate DIE factors. While the proposed proteomic analyses did not provide information that would allow DIE factors to be identified, the analyses provided another important set of observations. Proteomic analysis suggested that proteins associated with the cellular response to oxidative stress and mitochondrial function were elevated in the medium from unstable clones in a manner consistent with mitochondrial dysfunction. These findings correlate with previous studies of these clones that demonstrated functional differences between the mitochondria of stable and unstable clones. These

  8. On reaction mechanisms involved in the deuteron–induced surrogate reactions

    SciTech Connect (OSTI)

    Avrigeanu, M.; Avrigeanu, V.; Mănăilescu, C.

    2015-02-24

    An extended analysis of the nuclear reaction mechanisms involved within deuteron interaction with nuclei, namely the breakup, stripping, pick-up, pre-equilibrium emission, and evaporation from fully equilibrated compound nucleus, is presented in order to highlight the importance of the direct mechanisms still neglected in the analysis of deuteron-induced surrogate reactions. Particularly, the dominance of the breakup mechanism at low energies around the Coulomb barrier should be considered in the case of (d,x) surrogate reactions on actinide target nuclei.

  9. Electric-field enhanced performance in catalysis and solid-state devices involving gases

    DOE Patents [OSTI]

    Blackburn, Bryan M.; Wachsman, Eric D.; Van Assche, IV, Frederick Martin

    2015-05-19

    Electrode configurations for electric-field enhanced performance in catalysis and solid-state devices involving gases are provided. According to an embodiment, electric-field electrodes can be incorporated in devices such as gas sensors and fuel cells to shape an electric field provided with respect to sensing electrodes for the gas sensors and surfaces of the fuel cells. The shaped electric fields can alter surface dynamics, system thermodynamics, reaction kinetics, and adsorption/desorption processes. In one embodiment, ring-shaped electric-field electrodes can be provided around sensing electrodes of a planar gas sensor.

  10. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    Not Available

    1999-01-01

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  11. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    1999-11-01

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  12. Tri-Party Agreement Agencies - Public involvement calendar - fiscal year 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    November 2014 December 2014 January 2015 February 2015 March 2015 April 2015 Federal Holidays November 11 November 27 December 25 January 1 January 19 February 16 Hanford Advisory Board (HAB) http://www.hanford.gov/page.cfm/hab November 5-6 Richland Red Lion February 4-5 April 8-9 HAB Committee Weeks http://www.hanford.gov/?page=455 River and Plateau (RAP) Health, Safety and Environmental Protection (HSEP) Tank Waste (TW) Public Involvement and Communications (PIC) Budgets and Contracts (BC)

  13. EIS-0467: Notice of Intent to Prepare an Environmental Impact Statement and Notice of Floodplains and Wetlands Involvement

    Broader source: Energy.gov [DOE]

    Acquisition of a Natural Gas Pipeline and Natural Gas Utility Service at the Hanford Site, Richland, WA, and Notice of Floodplains and Wetlands Involvement

  14. Pseudobond parameters for QM/MM studies involving nucleosides, nucleotides, and their analogs

    SciTech Connect (OSTI)

    Chaudret, Robin; Parks, Jerry M; Yang, Weitao

    2013-01-01

    In biological systems involving nucleosides, nucleotides, or their respective analogs, the ribose sugar moiety is the most common reaction site, for example, during DNA replication and repair. How- ever, nucleic bases, which comprise a sizable portion of nucleotide molecules, are usually unreactive during such processes. In quantum mechanical/molecular simulations of nucleic acid reactivity, it may therefore be advantageous to describe specific ribosyl or ribosyl phosphate groups quantum me- chanically and their respective nucleic bases with a molecular mechanics potential function. Here, we have extended the pseudobond approach to enable quantum mechanical/molecular mechanical simulations involving nucleotides, nucleosides, and their analogs in which the interface between the two subsystems is located between the sugar and the base, namely, the C(sp3) N(sp2) bond. The pseudobond parameters were optimized on a training set of 10 molecules representing several nu- cleotide and nucleoside bases and analogs, and they were then tested on a larger test set of 20 diverse molecules. Particular emphasis was placed on providing accurate geometries and electrostatic prop- erties, including electrostatic potential, natural bond orbital (NBO) and atoms in molecules (AIM) charges and AIM first moments. We also tested the optimized parameters on five nucleotide and nu- cleoside analogues of pharmaceutical relevance and a small polypeptide (triglycine). Accuracy was maintained for these systems, which highlights the generality and transferability of the pseudobond approach. 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772182

  15. Examining the consistency relations describing the three-point functions involving tensors

    SciTech Connect (OSTI)

    Sreenath, V.; Sriramkumar, L. E-mail: sriram@physics.iitm.ac.in

    2014-10-01

    It is well known that the non-Gaussianity parameter f{sub NL} characterizing the scalar bi-spectrum can be expressed in terms of the scalar spectral index in the squeezed limit, a property that is referred to as the consistency relation. In contrast to the scalar bi-spectrum, the three-point cross-correlations involving scalars and tensors and the tensor bi-spectrum have not received adequate attention, which can be largely attributed to the fact that the tensors had remained undetected at the level of the power spectrum until very recently. The detection of the imprints of the primordial tensor perturbations by BICEP2 and its indication of a rather high tensor-to-scalar ratio, if confirmed, can open up a new window for understanding the tensor perturbations, not only at the level of the power spectrum, but also in the realm of non-Gaussianities. In this work, we consider the consistency relations associated with the three-point cross-correlations involving scalars and tensors as well as the tensor bi-spectrum in inflationary models driven by a single, canonical, scalar field. Characterizing the cross-correlations in terms of the dimensionless non-Gaussianity parameters C{sub NL}{sup R} and C{sub NL}{sup γ} that we had introduced earlier, we express the consistency relations governing the cross-correlations as relations between these non-Gaussianity parameters and the scalar or tensor spectral indices, in a fashion similar to that of the purely scalar case. We also discuss the corresponding relation for the non-Gaussianity parameter h{sub NL} used to describe the tensor bi-spectrum. We analytically establish these consistency relations explicitly in the following two situations: a simple example involving a specific case of power law inflation and a non-trivial scenario in the so-called Starobinsky model that is governed by a linear potential with a sharp change in its slope. We also numerically verify the consistency relations in three types of inflationary

  16. The community environmental monitoring program: a model for stakeholder involvement in environmental monitoring

    SciTech Connect (OSTI)

    Hartwell, William T.; Shafer, David S.

    2007-07-01

    Since 1981, the Community Environmental Monitoring Program (CEMP) has involved stakeholders directly in its daily operation and data collection, as well as in dissemination of information on radiological surveillance in communities surrounding the Nevada Test Site (NTS), the primary location where the United States (US) conducted nuclear testing until 1992. The CEMP is funded by the US Department of Energy's National Nuclear Security Administration, and is administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. The CEMP provides training workshops for stakeholders involved in the program, and educational outreach to address public concerns about health risk and environmental impacts from past and ongoing NTS activities. The network includes 29 monitoring stations located across an approximately 160,000 km{sup 2} area of Nevada, Utah and California in the southwestern US. The principal radiological instruments are pressurized ion chambers for measuring gamma radiation, and particulate air samplers, primarily for alpha/beta detection. Stations also employ a full suite of meteorological instruments, allowing for improved interpretation of the effects of meteorological events on background radiation levels. Station sensors are wired to state-of-the-art data-loggers that are capable of several weeks of on-site data storage, and that work in tandem with a communications system that integrates DSL and wireless internet, land line and cellular phone, and satellite technologies for data transfer. Data are managed through a platform maintained by the Western Regional Climate Center (WRCC) that DRI operates for the U.S. National Oceanic and Atmospheric Administration. The WRCC platform allows for near real-time upload and display of current monitoring information in tabular and graphical formats on a public web site. Archival data for each station are also available on-line, providing the ability to perform trending analyses or calculate

  17. Model studies in cytochrome P-450 mediated toxicity of halogenated compounds: radical processes involving iron porphyrins

    SciTech Connect (OSTI)

    Brault, D.

    1985-12-01

    Haloalkane toxicity originates from attack on biological targets by reactive intermediates derived from haloalkane metabolism by a hemoprotein, cytochrome P-450. Carbon-centered radicals and their peroxylderivatives are most likely involved. The reactions of iron porphyrin - a model for cytochrome P-450 - with various carbon-centered and peroxyl radicals generated by pulse radiolysis are examined. Competition between iron porphyrin and unsaturated fatty acids for attack by peroxyl radicals is pointed out. These kinetic data are used to derive a model for toxicity of haloalkanes with particular attention to carbon tetrachloride and halothane. The importance of local oxygen concentration and structural arrangement of fatty acids around cytochrome P-450 is emphasized. 56 references.

  18. Yellow affinity substance involved in the cellulolytic system of Clostridium thermocellum

    SciTech Connect (OSTI)

    Ljungdahl, L.G.; Pettersson, B.; Eriksson, K.E.; Wiegel, J.

    1983-01-01

    Clostridium thermocellum produces a yellow substance when fermenting cellulose. This substance is attached to the cellulose particles. Cellulose with the yellow substance, obtained from cultures of C. thermocellum, binds effectively endo-1,4-..beta..-glucanase produced by the bacterium and was used in an affinity column for purification of the enzyme. At the beginning of fermentation of cellulose, most of the endoglucanase was bound to the yellow cellulose. As the fermentation proceeded, the enzyme appeared free in the culture fluid. The endoglucanase bound to the yellow cellulose could be extracted by distilled water from the cellulose, but not by solutions with 5 mM or higher concentrations of salts or buffers. It is proposed that the yellow substance is involved in the cellulolytic system of C. thermocellum. 30 references, 3 figures, 3 tables.

  19. Pore scale modeling of reactive transport involved in geologic CO2 sequestration

    SciTech Connect (OSTI)

    Kang, Qinjin; Lichtner, Peter C; Viswanathan, Hari S; Abdel-fattah, Amr I

    2009-01-01

    We apply a multi-component reactive transport lattice Boltzmann model developed in previolls studies to modeling the injection of a C02 saturated brine into various porous media structures at temperature T=25 and 80 C. The porous media are originally consisted of calcite. A chemical system consisting of Na+, Ca2+, Mg2+, H+, CO2(aq), and CI-is considered. The fluid flow, advection and diHusion of aqueous species, homogeneous reactions occurring in the bulk fluid, as weB as the dissolution of calcite and precipitation of dolomite are simulated at the pore scale. The effects of porous media structure on reactive transport are investigated. The results are compared with continuum scale modeling and the agreement and discrepancy are discussed. This work may shed some light on the fundamental physics occurring at the pore scale for reactive transport involved in geologic C02 sequestration.

  20. Success stories? an analysis of stakeholder involvement in the Department of Energy`s Office of Environmental Management

    SciTech Connect (OSTI)

    Beck, D.M.; Kelly, C.; Forbes, E.

    1995-12-01

    In several studies conducted by the Office of Environmental Management, the Department of Energy (DOE) has begun its first analysis of the benefits of stakeholder involvement. The studies seek to determine how public participation in DOE activities has contributed to cost savings, has changed the course of action for environmental projects, and has influenced the priorities of a national environmental program. This presentation will discuss the results and conclusions of following three studies: Stakeholder Survey of Trust and Confidence; the Success Stories study; and the Site-Specific Advisory Board Evaluation. These studies are taking their data from environmental management projects at Department of Energy sites throughout the United States. The studies of stakeholder involvement are currently analyzing the role of several variables in stakeholder involvement including the climate surrounding the environmental project or decision, the strategies used by DOE, the nature of the actual interactions, the attempts to reach consensus among interested parties, the role played by primary decision-makers, the goals set by the Department or by its stakeholders, and the revision of strategies during the stakeholder involvement process. Based on this analysis the planning and execution of future stakeholder involvement activities in Environmental Management will be improved. The study goal of establishing a set of factors that characterize successful stakeholder involvement within the Environmental Management program, will allow inference as to stakeholder involvement in other Federal and private environmental projects.

  1. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis

    SciTech Connect (OSTI)

    Pauly, Markus; Sorensen, Susanne Oxenboll; Harholt, Jesper; Geshi, Naomi; Sakuragi, Yumiko; Moller, Isabel; Zandleven, Joris; Bernal, Adriana J.; Jensen, Niels Bjerg; Sorensen, Charlotte; Jensen, Jacob K.; Beldman, Gerrit; Willats, William G.T.; Scheller, Henrik

    2009-08-19

    Xylogalacturonan (XGA) is a class of pectic polysaccharide found in plant cell walls. The Arabidopsis thaliana locus At5g33290 encodes a predicted Type II membrane protein, and insertion mutants of the At5g33290 locus had decreased cell wall xylose. Immunological studies, enzymatic extraction of polysaccharides, monosaccharide linkage analysis, and oligosaccharide mass profiling were employed to identify the affected cell wall polymer. Pectic XGA was reduced to much lower levels in mutant than in wild-type leaves, indicating a role of At5g33290 in XGA biosynthesis. The mutated gene was designated xylogalacturonan deficient1 (xgd1). Transformation of the xgd1-1 mutant with the wild-type gene restored XGA to wild-type levels. XGD1 protein heterologously expressed in Nicotiana benthamiana catalyzed the transfer of xylose from UDP-xylose onto oligogalacturonides and endogenous acceptors. The products formed could be hydrolyzed with an XGA-specific hydrolase. These results confirm that the XGD1 protein is a XGA xylosyltransferase. The protein was shown by expression of a fluorescent fusion protein in N. benthamiana to be localized in the Golgi vesicles as expected for a glycosyltransferase involved in pectin biosynthesis.

  2. Advantages of customer/supplier involvement in the upgrade of River Bend`s IST program

    SciTech Connect (OSTI)

    Womack, R.L.; Addison, J.A.

    1996-12-01

    At River Bend Station, IST testing had problems. Operations could not perform the test with the required repeatability; engineering could not reliably trend test data to detect degradation; licensing was heavily burdened with regulatory concerns; and maintenance could not do preventative maintenance because of poor prediction of system health status. Using Energy`s Total Quality principles, it was determined that the causes were: lack of ownership, inadequate test equipment usage, lack of adequate procedures, and lack of program maintenance. After identifying the customers and suppliers of the IST program data, Energy management put together an upgrade team to address these concerns. These customers and suppliers made up the IST upgrade team. The team`s mission was to supply River Bend with a reliable, functional, industry correct and user friendly IST program. The IST program in place went through a verification process that identified and corrected over 400 individual program discrepancies. Over 200 components were identified for improved testing methods. An IST basis document was developed. The operations department was trained on ASME Section XI testing. All IST tests have been simplified and shortened, due to heavy involvement by operations in the procedure development process. This significantly reduced testing time, resulting in lower cost, less dose and greater system availability.

  3. Let7a involves in neural stem cell differentiation relating with TLX level

    SciTech Connect (OSTI)

    Song, Juhyun; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

    2015-07-10

    Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reported significant functions in NSC self-renewal and differentiation through the post-transcriptional regulation of neurogenesis genes. MicroRNA-Let7a (Let7a) has known as the regulator of diverse cellular mechanisms including cell differentiation and proliferation. In present study, we investigated whether Let7a regulates NSC differentiation by targeting the nuclear receptor TLX, which is an essential regulator of NSC self-renewal, proliferation and differentiation. We performed the following experiments: western blot analysis, TaqMan assay, RT-PCR, and immunocytochemistry to confirm the alteration of NSCs. Our data showed that let7a play important roles in controlling NSC fate determination. Thus, manipulating Let-7A and TLX could be a novel strategy to enhance the efficiency of NSC's neuronal differentiation for CNS disorders. - Highlights: • Let7a influences on NSC differentiation and proliferation. • Let7a involves in mainly NSC differentiation rather than proliferation. • Let7a positively regulates the TLX expression.

  4. Latexin is involved in bone morphogenetic protein-2-induced chondrocyte differentiation

    SciTech Connect (OSTI)

    Kadouchi, Ichiro; Sakamoto, Kei; Tangjiao, Liu; Murakami, Takashi; Kobayashi, Eiji; Hoshino, Yuichi; Yamaguchi, Akira

    2009-01-16

    Latexin is the only known carboxypeptidase A inhibitor in mammals. We previously demonstrated that BMP-2 significantly induced latexin expression in Runx2-deficient mesenchymal cells (RD-C6 cells), during chondrocyte and osteoblast differentiation. In this study, we investigated latexin expression in the skeleton and its role in chondrocyte differentiation. Immunohistochemical studies revealed that proliferating and prehypertrophic chondrocytes expressed latexin during skeletogenesis and bone fracture repair. In the early phase of bone fracture, latexin mRNA expression was dramatically upregulated. BMP-2 upregulated the expression of the mRNAs of latexin, Col2a1, and the gene encoding aggrecan (Agc1) in a micromass culture of C3H10T1/2 cells. Overexpression of latexin additively stimulated the BMP-2-induced expression of the mRNAs of Col2a, Agc1, and Col10a1. BMP-2 treatment upregulated Sox9 expression, and Sox9 stimulated the promoter activity of latexin. These results indicate that latexin is involved in BMP-2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration.

  5. Endovascular Treatment of Infrarenal Abdominal Aortic Lesions With or Without Common Iliac Artery Involvement

    SciTech Connect (OSTI)

    Oender, Hakan; Oguzkurt, Levent; Guer, Serkan; Tekbas, Gueven; Guerel, Kamil; Coskun, Isa; Oezkan, Ugur

    2013-02-15

    To evaluate the results of stent placement for obstructive atherosclerotic aortic disease with or without involvement of the common iliac artery. Forty patients had self-expanding stents primarily or after balloon dilatation in the abdominal aorta between January 2005 and May 2011. All patients had trouble walking. Follow-up examinations were performed with clinical visits; these included color Doppler ultrasonography and computed tomographic angiography. Technical, clinical, and hemodynamic success was achieved in all patients. None of the patients underwent reintervention during the follow-up period, which ranged from 3 months to 6 years (median 24 months). Nine complications occurred in six patients. Of the nine complications, four were distal thromboembolisms, which were successfully treated with catheter-directed thrombolysis or anticoagulation therapy. Endovascular treatment of the obstructive aortic disease using self-expanding stents was safe and effective, with high technical success and long-term patency. Thromboembolic complications were high even though direct stenting was considered protective for thromboembolism formation. Particularly for infrarenal aortic stenosis, it can be recommended as the first-line treatment option for patients with obstructive atherosclerotic aortic disease.

  6. Extension of DOE N 206.5, Response and Notification Procedures for Data Breaches Involving Personally Identifiable Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-10-09

    This Notice extends DOE N 206.5, Response and Notification Procedures for Data Breaches Involving Personally Identifiable Information, dated 10-9-07, until 1-9-09.

  7. Genes involved in long-chain alkene biosynthesis in Micrococcus luteus

    SciTech Connect (OSTI)

    Beller, Harry R.; Goh, Ee-Been; Keasling, Jay D.

    2010-01-07

    Aliphatic hydrocarbons are highly appealing targets for advanced cellulosic biofuels, as they are already predominant components of petroleum-based gasoline and diesel fuels. We have studied alkene biosynthesis in Micrococcus luteus ATCC 4698, a close relative of Sarcina lutea (now Kocuria rhizophila), which four decades ago was reported to biosynthesize iso- and anteiso branched, long-chain alkenes. The underlying biochemistry and genetics of alkene biosynthesis were not elucidated in those studies. We show here that heterologous expression of a three-gene cluster from M. luteus (Mlut_13230-13250) in a fatty-acid overproducing E. coli strain resulted in production of long-chain alkenes, predominantly 27:3 and 29:3 (no. carbon atoms: no. C=C bonds). Heterologous expression of Mlut_13230 (oleA) alone produced no long-chain alkenes but unsaturated aliphatic monoketones, predominantly 27:2, and in vitro studies with the purified Mlut_13230 protein and tetradecanoyl-CoA produced the same C27 monoketone. Gas chromatography-time of flight mass spectrometry confirmed the elemental composition of all detected long-chain alkenes and monoketones (putative intermediates of alkene biosynthesis). Negative controls demonstrated that the M. luteus genes were responsible for production of these metabolites. Studies with wild-type M. luteus showed that the transcript copy number of Mlut_13230-13250 and the concentrations of 29:1 alkene isomers (the dominant alkenes produced by this strain) generally corresponded with bacterial population over time. We propose a metabolic pathway for alkene biosynthesis starting with acyl-CoA (or -ACP) thioesters and involving decarboxylative Claisen condensation as a key step, which we believe is catalyzed by OleA. Such activity is consistent with our data and with the homology (including the conserved Cys-His-Asn catalytic triad) of Mlut_13230 (OleA) to FabH (?-ketoacyl-ACP synthase III), which catalyzes decarboxylative Claisen condensation during

  8. Consent Versus Consensus - Stakehold Involvement in the Identification of Necessary and Sufficient Transportation

    SciTech Connect (OSTI)

    Fawcett, Ricky Lee; Kramer, George Leroy Jr.

    2003-03-01

    Transportation (DOT) and the Nuclear Regulatory Commission (NRC) to provide for the protection of the public and the environment; historically these regulations have proven quite sufficient. Even so, when the Department of Energy (DOE) makes radioactive materials shipments, that are deemed to be a major federal activity, regulations under the National Environmental Policy Act require that public input on safety issues be sought. This requirement leads to interactions with State, Tribal and local stakeholders that often result in the imposition of extra-regulatory requirements requirements beyond those prescribed by DOT and NRC regulations. Unfortunately, these additional requirements virtually always increase costs and delay schedules, and usually do so without significantly increasing, and possibly even decreasing overall transportation safety. We believe that this problem arises because of efforts to achieve stakeholder consensus rather than stakeholder consent, where consensus connotes universal agreement with all aspects of the program, while consent, as used here, is simple agreement with the overall course of action. Gaining consensus entails extensive negotiations because all aspects and requirements of the project must be agreed to by each stakeholder. Gaining consent, on the other hand, requires only that stakeholders be satisfied that the project, as planned, provides adequately for their safety needs. This article addresses the issue of consent versus consensus and proposes a systematic, decision science process for reaching consent. Key steps in this proposed process are early identification and involvement of stakeholders, compilation of their concerns, perceptions, needs, causes, and translation of that information into an appropriate set of derived requirements. These derived requirements, along with already-established DOT and NRC regulatory requirements, form the necessary and sufficient conditions for safe transportation and for obtaining

  9. Physical formulation and numerical algorithm for simulating N immiscible incompressible fluids involving general order parameters

    SciTech Connect (OSTI)

    Dong, S.

    2015-02-15

    We present a family of physical formulations, and a numerical algorithm, based on a class of general order parameters for simulating the motion of a mixture of N (N⩾2) immiscible incompressible fluids with given densities, dynamic viscosities, and pairwise surface tensions. The N-phase formulations stem from a phase field model we developed in a recent work based on the conservations of mass/momentum, and the second law of thermodynamics. The introduction of general order parameters leads to an extremely strongly-coupled system of (N−1) phase field equations. On the other hand, the general form enables one to compute the N-phase mixing energy density coefficients in an explicit fashion in terms of the pairwise surface tensions. We show that the increased complexity in the form of the phase field equations associated with general order parameters in actuality does not cause essential computational difficulties. Our numerical algorithm reformulates the (N−1) strongly-coupled phase field equations for general order parameters into 2(N−1) Helmholtz-type equations that are completely de-coupled from one another. This leads to a computational complexity comparable to that for the simplified phase field equations associated with certain special choice of the order parameters. We demonstrate the capabilities of the method developed herein using several test problems involving multiple fluid phases and large contrasts in densities and viscosities among the multitude of fluids. In particular, by comparing simulation results with the Langmuir–de Gennes theory of floating liquid lenses we show that the method using general order parameters produces physically accurate results for multiple fluid phases.

  10. Public Involvement Plan Public Involvement Plan

    Broader source: Energy.gov (indexed) [DOE]

    URS | CH2M Oak Ridge LLC Managing and Safely Delivering the Department of Energy's Vision for the East Tennessee Technology Park Mission under contract DE-SC-0004645 Message from ...

  11. Raman accumulator as a fusion laser driver

    DOE Patents [OSTI]

    George, E. Victor; Swingle, James C.

    1985-01-01

    Apparatus for simultaneous laser pulse amplification and compression, using multiple pass Raman scattering in one Raman cell and pulse switchout from the optical cavity through use of a dichroic device associated with the Raman cell.

  12. Overload protection circuit for output driver

    DOE Patents [OSTI]

    Stewart, Roger G.

    1982-05-11

    A protection circuit for preventing excessive power dissipation in an output transistor whose conduction path is connected between a power terminal and an output terminal. The protection circuit includes means for sensing the application of a turn on signal to the output transistor and the voltage at the output terminal. When the turn on signal is maintained for a period of time greater than a given period without the voltage at the output terminal reaching a predetermined value, the protection circuit decreases the turn on signal to, and the current conduction through, the output transistor.

  13. WBG Gate Drivers for Power Modules

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  14. Regulatory Drivers | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vehicles or motor vehicle engines "which in his judgment causes, or contributes to, air pollution which may reasonably be anticipated to endanger public health or welfare."7...

  15. Residential Prosumers: Drivers and Policy Options

    Office of Energy Efficiency and Renewable Energy (EERE)

    The rise of the solar photovoltaic "prosumers" has the potential to transform the 100-year-old centralized electric utility model into a more decentralized and interactive system. In some countries, it is now more cost-effective for households to produce their own power from PV than to purchase electricity from the grid. However, a prosumer "revolution" under which decentralized adoption of PV occurs on its own, in the absence of supportive policies or regulatory conditions, has not yet arrived. Self-consumption of solar PV is a growing trend globally, but its expansion remains within policy makers’ ability to control and develop.

  16. Raman accumulator as a fusion laser driver

    DOE Patents [OSTI]

    George, E.V.; Swingle, J.C.

    1982-03-31

    Apparatus for simultaneous laser pulse amplification and compression, using multiple pass Raman scattering in one Raman cell and pulse switchout from the optical cavity through use of a dichroic device associated with the Raman cell.

  17. Alternative Fuel Driver Training Companion Manual

    SciTech Connect (OSTI)

    Not Available

    2005-09-01

    Training manual serves as a companion to alternative fuel training presentations on the fueling and use of vehicles that run on compressed natural gas, biodiesel, E85, and propane.

  18. TEAM 1 Drivers License.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    I Core Status: new users must complete 2 training sessions and pass a sample exchange exam to work independently during Core sessions (regular work hours). Flex Status: core users must complete 5 Core sessions and pass a driving test to work during Flex sessions (evening and weekend hours). All TEAM I scheduling must be coordinated through Peter Ercius at PErcius@lbl.gov. You may only be assigned two sessions per month. CORE LICENSE TEST Safety  Understand emergency shutdown procedure 

  19. The Jefferson lab FEL driver ERLs

    SciTech Connect (OSTI)

    Douglas, David R.; Tennant, Christopher D.

    2013-11-01

    Jefferson Lab has - for over a decade - been operating high power IR and UV FELs using CW energy recovering linacs based on DC photocathode electron sources and CEBAF SRF technology. These machines have unique combinations of beam quality, power, and operational flexibility, and thus offer significant opportunity for experiments that use low and medium energy (several tens - few hundreds of MeV) electron beams. We will describe the systems and detail their present and near-term (potential) performance. Recent internal-target analysis and validation testing will be discussed, and schemes for single- and two-pass fixed target operation described. An introduction to subsequent discussions of beam quality and upgrade paths to polarized operation/higher energy will be given.

  20. Switched-capacitor isolated LED driver

    DOE Patents [OSTI]

    Sanders, Seth R.; Kline, Mitchell

    2016-03-22

    A switched-capacitor voltage converter which is particularly well-suited for receiving a line voltage from which to drive current through a series of light emitting diodes (LEDs). Input voltage is rectified in a multi-level rectifier network having switched capacitors in an ascending-bank configuration for passing voltages in uniform steps between zero volts up to full received voltage V.sub.DC. A regulator section, operating on V.sub.DC, comprises switched-capacitor stages of H-bridge switching and flying capacitors. A current controlled oscillator drives the states of the switched-capacitor stages and changes its frequency to maintain a constant current to the load. Embodiments are described for isolating the load from the mains, utilizing an LC tank circuit or a multi-primary-winding transformer.

  1. Be a Safe and Efficient Winter Driver

    Broader source: Energy.gov [DOE]

    We've been advising you on ways to make the home more energy smart, so let's talk about your car for a moment.

  2. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    SciTech Connect (OSTI)

    Houseworth, Jim; Rutqvist, Jonny; Asahina, Daisuke; Chen, Fei; Vilarrasa, Victor; Liu, Hui-Hai; Birkholzer, Jens

    2013-11-06

    assessment. For the purpose of validating modeling capabilities for thermal-hydro-mechanical (THM) processes, we developed a suite of simulation models for the planned full-scale FE Experiment to be conducted in the Mont Terri URL, including a full three-dimensional model that will be used for direct comparison to experimental data once available. We performed for the first time a THM analysis involving the Barcelona Basic Model (BBM) in a full three-dimensional field setting for modeling the geomechanical behavior of the buffer material and its interaction with the argillaceous host rock. We have simulated a well defined benchmark that will be used for codeto- code verification against modeling results from other international modeling teams. The analysis highlights the complex coupled geomechanical behavior in the buffer and its interaction with the surrounding rock and the importance of a well characterized buffer material in terms of THM properties. A new geomechanical fracture-damage model, TOUGH-RBSN, was applied to investigate damage behavior in the ongoing HG-A test at Mont Terri URL. Two model modifications have been implemented so that the Rigid-Body-Spring-Network (RBSN) model can be used for analysis of fracturing around the HG-A microtunnel. These modifications are (1) a methodology to compute fracture generation under compressive stress conditions and (2) a method to represent anisotropic elastic and strength properties. The method for computing fracture generation under compressive load produces results that roughly follow trends expected for homogeneous and layered systems. Anisotropic properties for the bulk rock were represented in the RBSN model using layered heterogeneity and gave bulk material responses in line with expectations. These model improvements were implemented for an initial model of fracture damage at the HG-A test. While the HG-A test model results show some similarities with the test observations, differences between the model results and

  3. TPA Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in 2008 32-33 Add to Agency Contact List(s) 34 Additional Comments GOALS & ... Meetings (53%) 32-33 Add to Agency Contact List(s) 21 Contacts Added (34%) 34 ...

  4. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Budget and Contracts Committee Chair 1 : Jerry Peltier 4 , Member Vice Chair 1 : Don Bouchey 4 , Member Committee Members 2 : Don Bouchey Jerry Peltier Gary Garnant Gerry Pollet Mike Korenko Ed Revell Susan Leckband 4 Gene Van Liew Ken Niles Unofficial Committee Members or Other Interested Parties 3 : Earl Fordham Steve Hudson 4 Facilitator: Cathy McCague 4 Agency and Technical Support: Kris Holmes 4 DOE-RL Randy Bradbury 4 Ecology Dieter Bohrmann DOE-ORP Emy Laija 4

  5. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health, Safety, Environmental Protection Chair 1 : Becky Holland 4 , Member Vice Chair 1 : Richard Bloom 4 , Alternate Committee Members 2 : Richard Bloom Becky Holland Antone Brooks Steve Hudson 4 Jan Catrell Bob Legard Sam Dechter Margery Swint Dirk Dunning Unofficial Committee Members or Other Interested Parties 3 : Pam Larsen Susan Leckband 4 Mike Priddy Facilitator: Cathy McCague 4 Agency & Technical Support: Kris Holmes 4 DOE-RL Randy Bradbury 4 Ecology Dieter Bohrmann 4 DOE-ORP Emy

  6. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    River and Plateau Committee Chair 1 : Pam Larsen 4 , Member Vice Chair 1 : Jan Catrell 4 , Alternate Committee Members 2 : Don Bouchey Susan Leckband 4 Jan Catrell Larry Lockrem Shelley Cimon Liz Mattson Shannon Cram Emmett Moore Rob Davis Jerry Peltier Dale Engstrom Gerry Pollet Gary Garnant Dan Serres Floyd Hodges Bob Suyama Alex Klementiev Gene Van Liew Mike Korenko Jean Vanni Pam Larsen Dawn Wellman Unofficial Committee Members or Other Interested Parties 3 : Dirk Dunning Steve Hudson 4

  7. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tank Waste Committee Chair 1 : Bob Suyama 4 , Member Vice Chair 1 : Melanie Myers 4 , Member Committee Members 2 : David Bernhard Larry Lockrem Amoret Bunn Liz Matson Shelley Cimon Kristen McNall Shannon Cram Melanie Myers-Magnuson Rob Davis Bob Parks Dirk Dunning Dan Serres Floyd Hodges Bob Suyama Becky Holland Margery Swint Paul Kison Jean Vanni Paige Knight Dawn Wellman Pam Larsen Unofficial Committee Members or Other Interested Parties 3 : Steve Hudson 4 Gerry Pollet Susan Leckband 4

  8. De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cárdenas-Conejo, Yair; Carballo-Uicab, Víctor; Lieberman, Meric; Aguilar-Espinosa, Margarita; Comai, Luca; Rivera-Madrid, Renata

    2015-10-28

    Bixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L. An enzymatic pathway for bixin biosynthesis was inferred from homology of putative proteins encoded by differentially expressed seed cDNAs. Some activities were later validated in a heterologous system. Nevertheless, much of the pathway remains to be clarified. For example, it is essential to identify the methylerythritol phosphate (MEP) and carotenoid pathways genes. In order to investigate the MEP, carotenoid, and bixin pathways genes, total RNA from young leaves and two different developmental stages of seeds frommore » B. orellana were used for the construction of indexed mRNA libraries, sequenced on the Illumina HiSeq 2500 platform and assembled de novo using Velvet, CLC Genomics Workbench and CAP3 software. A total of 52,549 contigs were obtained with average length of 1,924 bp. Two phylogenetic analyses of inferred proteins, in one case encoded by thirteen general, single-copy cDNAs, in the other from carotenoid and MEP cDNAs, indicated that B. orellana is closely related to sister Malvales species cacao and cotton. Using homology, we identified 7 and 14 core gene products from the MEP and carotenoid pathways, respectively. Surprisingly, previously defined bixin pathway cDNAs were not present in our transcriptome. Here we propose a new set of gene products involved in bixin pathway. In conclusion, the identification and qRT-PCR quantification of cDNAs involved in annatto production suggest a hypothetical model for bixin biosynthesis that involve coordinated activation of some MEP, carotenoid and bixin pathway genes. These findings provide a better understanding of the mechanisms regulating these pathways and will facilitate the genetic improvement of B. orellana.« less

  9. Involved-Site Image-Guided Intensity Modulated Versus 3D Conformal Radiation Therapy in Early Stage Supradiaphragmatic Hodgkin Lymphoma

    SciTech Connect (OSTI)

    Filippi, Andrea Riccardo; Ciammella, Patrizia; Piva, Cristina; Ragona, Riccardo; Botto, Barbara; Gavarotti, Paolo; Merli, Francesco; Vitolo, Umberto; Iotti, Cinzia; Ricardi, Umberto

    2014-06-01

    Purpose: Image-guided intensity modulated radiation therapy (IG-IMRT) allows for margin reduction and highly conformal dose distribution, with consistent advantages in sparing of normal tissues. The purpose of this retrospective study was to compare involved-site IG-IMRT with involved-site 3D conformal RT (3D-CRT) in the treatment of early stage Hodgkin lymphoma (HL) involving the mediastinum, with efficacy and toxicity as primary clinical endpoints. Methods and Materials: We analyzed 90 stage IIA HL patients treated with either involved-site 3D-CRT or IG-IMRT between 2005 and 2012 in 2 different institutions. Inclusion criteria were favorable or unfavorable disease (according to European Organization for Research and Treatment of Cancer criteria), complete response after 3 to 4 cycles of an adriamycin- bleomycin-vinblastine-dacarbazine (ABVD) regimen plus 30 Gy as total radiation dose. Exclusion criteria were chemotherapy other than ABVD, partial response after ABVD, total radiation dose other than 30 Gy. Clinical endpoints were relapse-free survival (RFS) and acute toxicity. Results: Forty-nine patients were treated with 3D-CRT (54.4%) and 41 with IG-IMRT (45.6%). Median follow-up time was 54.2 months for 3D-CRT and 24.1 months for IG-IMRT. No differences in RFS were observed between the 2 groups, with 1 relapse each. Three-year RFS was 98.7% for 3D-CRT and 100% for IG-IMRT. Grade 2 toxicity events, mainly mucositis, were recorded in 32.7% of 3D-CRT patients (16 of 49) and in 9.8% of IG-IMRT patients (4 of 41). IG-IMRT was significantly associated with a lower incidence of grade 2 acute toxicity (P=.043). Conclusions: RFS rates at 3 years were extremely high in both groups, albeit the median follow-up time is different. Acute tolerance profiles were better for IG-IMRT than for 3D-CRT. Our preliminary results support the clinical safety and efficacy of advanced RT planning and delivery techniques in patients affected with early stage HL, achieving complete

  10. Microsoft Word - PNNL 24125 Probative Investigation of the Thermal Stability of Wastes Involved in February 2014 WIPP Waste Dru

    Office of Environmental Management (EM)

    PART 970.doc Microsoft Word - PART 970.doc Microsoft Word - PART 970.doc (1.03 MB) More Documents & Publications Searchable Electronic Department of Energy Acquisition Regulation Microsoft Word - Matrixpart2.doc AcqGuide70.52Matrixpart2Redo-OPAM

    PNNL-24125 Limited Distribution Probative Investigation of the Thermal Stability of Wastes Involved in February 2014 WIPP Waste Drum Breach Event March 2015 RD Scheele JM Schwantes BK McNamara MJ Minette DT Hobbs (SRNL) CA Barrett PNNL-24125

  11. Characterization of the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast

    SciTech Connect (OSTI)

    Watanabe, Nobuyoshi; Ikeda, Terumasa; Mizuki, Fumitaka; Tani, Tokio

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer We cloned the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast. Black-Right-Pointing-Pointer The ptr5{sup +} gene was found to encode nucleoporin 85 (Nup85). Black-Right-Pointing-Pointer Seh1p and Mlo3p are multi-copy suppressors for the ptr5 mutation. Black-Right-Pointing-Pointer Ptr5p/Nup85p functions in nuclear mRNA export through the mRNA export factor Rae1p. Black-Right-Pointing-Pointer Ptr5p/Nup85p interacts genetically with pre-mRNA splicing factors. -- Abstract: To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A){sup +} RNA transport] 1 to 11, which accumulate poly(A){sup +} RNA in the nucleus at a nonpermissive temperature in Schizosaccharomyces pombe. Of those, the ptr5-1 mutant shows dots- or a ring-like accumulation of poly(A){sup +} RNA at the nuclear periphery after shifting to the nonpermissive temperature. We cloned the ptr5{sup +} gene and found that it encodes a component of the nuclear pore complex (NPC), nucleoporin 85 (Nup85). The ptr5-1 mutant shows no defects in protein transport, suggesting the specific involvement of Ptr5p/Nup85p in nuclear mRNA export in S. pombe. We identified Seh1p, a nucleoporin interacting with Nup85p, an mRNA-binding protein Mlo3p, and Sac3p, a component of the TREX-2 complex involved in coupling of nuclear mRNA export with transcription, as multi-copy suppressors for the ptr5-1 mutation. In addition, we found that the ptr5-1 mutation is synthetically lethal with a mutation of the mRNA export factor Rae1p, and that the double mutant exaggerates defective nuclear mRNA export, suggesting that Ptr5p/Nup85p is involved in nuclear mRNA export through Rae1p. Interestingly, the ptr5-1 mutation also showed synthetic effects with several prp pre-mRNA splicing mutations, suggesting a functional linkage between the NPCs and the splicing apparatus in the yeast nucleus.

  12. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

    SciTech Connect (OSTI)

    Nagane, Masaki; Yasui, Hironobu; Sakai, Yuri; Yamamori, Tohru; Niwa, Koichi; Hattori, Yuichi; Kondo, Takashi; Inanami, Osamu

    2015-01-02

    Highlights: eNOS activity is increased in BAECs exposed to X-rays. ATM is involved in this increased eNOS activity. HSP90 modulates the radiation-induced activation of ATM and eNOS. - Abstract: In this study, the involvement of ataxia telangiectasia mutated (ATM) kinase and heat shock protein 90 (HSP90) in endothelial nitric oxide synthase (eNOS) activation was investigated in X-irradiated bovine aortic endothelial cells. The activity of nitric oxide synthase (NOS) and the phosphorylation of serine 1179 of eNOS (eNOS-Ser1179) were significantly increased in irradiated cells. The radiation-induced increases in NOS activity and eNOS-Ser1179 phosphorylation levels were significantly reduced by treatment with either an ATM inhibitor (Ku-60019) or an HSP90 inhibitor (geldanamycin). Geldanamycin was furthermore found to suppress the radiation-induced phosphorylation of ATM-Ser1181. Our results indicate that the radiation-induced eNOS activation in bovine aortic endothelial cells is regulated by ATM and HSP90.

  13. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Ruben A. Abagyan, PhD

    2004-04-15

    OAK-B135 DNA Damage Recognition and Repair (DDR and R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. the authors have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR and R process. The significant achievements of this project include: (1) Construction of the computational pipeline for searching DDR and R genes, building and validation of 3D models of proteins involved in DDR and R; (2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; (3) Important improvement of macromolecular docking technology and its application to predict the DNA-Protein complex conformation; (4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; (5) Construction and maintenance of the DNA Damage Recognition and Repair Database; and (6) Producing 14 research papers (10 published and 4 in preparation).

  14. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Abagyan, Ruben; An, Jianghong

    2005-08-12

    DNA Damage Recognition and Repair (DDR&R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. We have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR&R process. The significant achievements of this project include: 1) Construction of the computational pipeline for searching DDR&R genes, building and validation of 3D models of proteins involved in DDR&R; 2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; and the development of a method to predict the effects of mutations. Large scale testing of technology to identify novel small binding pockets in protein structures leading to new DDRR inhibitor strategies 3) Improvements of macromolecular docking technology (see the CAPRI 1-3 and 4-5 results) 4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; 5) Construction and maintenance of the DNA Damage Recognition and Repair Database; 6) Producing 15 research papers (12 published and 3 in preparation).

  15. DOE Technical Standards List. Directory of DOE and contractor personnel involved in non-government standards activities

    SciTech Connect (OSTI)

    1997-06-01

    This is a periodic report on the level of agency participation in non-Government standards activities. This technical standards list is intended to assist US Department of Energy (DOE) management and other personnel involved in the DOE technical Standards Program by identifying those participating individuals. The body of this document contains a listing of DOE employees and DOE contractors who have submitted a Record of Non-Government Standards Activity. Additional names were added from rosters supplied by non-Government standards bodies. Appendices to this document are provided to list the information by parent employment organization, by non-Government standards activity, and by the proper names of the non-Government standards organizations and committees.

  16. DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

    SciTech Connect (OSTI)

    Tsujimoto, Y.; Bashir, M.M.; Givol, I.; Cossman, J.; Jaffe, E.; Croce, C.M.

    1987-03-01

    In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.

  17. The Orosomucoid 1 protein is involved in the vitamin D – mediated macrophage de-activation process

    SciTech Connect (OSTI)

    Gemelli, Claudia; Martello, Andrea; Montanari, Monica; Zanocco Marani, Tommaso; Salsi, Valentina; Zappavigna, Vincenzo; Parenti, Sandra; Vignudelli, Tatiana; Selmi, Tommaso; Ferrari, Sergio; Grande, Alexis

    2013-12-10

    Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties. The present study was designed to identify a possible correlation between ORM1 and Vitamin D3 (1,25(OH)2D3), a hormone exerting a widespread effect on cell proliferation, differentiation and regulation of the immune system. In particular, the data described here indicated that ORM1 is a 1,25(OH)2D3 primary response gene, characterized by the presence of a VDRE element inside the 1 kb sequence of its proximal promoter region. This finding was demonstrated with gene expression studies, Chromatin Immunoprecipitation and luciferase transactivation experiments and confirmed by VDR full length and dominant negative over-expression. In addition, several experiments carried out in human normal monocytes demonstrated that the 1,25(OH)2D3 – VDR – ORM1 pathway plays a functional role inside the macrophage de-activation process and that ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. - Highlights: • ORM1 is a Vitamin D primary response gene. • VD and its receptor VDR are involved in the de-activation process mediated by human resident macrophages. • The signaling pathway VD-VDR-ORM1 plays an important role in the control of macrophage de-activation process. • ORM1 may be defined as a signaling molecule implicated in the maintenance of tissue homeostasis and remodeling.

  18. Selection of potential IAEA inspection strategies involving cascade access at the Portsmouth Gas Centrifuge Enrichment Plant (GCEP)

    SciTech Connect (OSTI)

    Not Available

    1981-04-13

    This report has been prepared as a US contribution to Team 4 of the Hexapartite Safeguards Project. It provides to the Team 4 participants one example of an approach, which has been used in the United States, to developing a range of safeguards strategies involving differing degrees of access to cascade areas of centrifuge enrichment plants. Its purpose is to facilitate the work of other Hexapartite participants in completing Task II of Team 4's terms of reference. The scope of this report is limited to identifying safeguards approaches for the Portsmouth Gas Centrifuge Enrichment Plant (GCEP) which involve differing degrees of access to the cascade area. This report provides a method for selecting cascade access inspection strategies at GCEP which appear promising for more detailed evaluation. It is quite important to note, however, that the effectiveness and practicability of these strategies have not been established at the present. In addition, some strategies have been included on the basis of very preliminary calculations and considerations which have not been validated. Thus, some of these strategies may ultimately be rejected because they prove to be impracticable. Considerations of cost and the possible transfer of information and technology related to the production of enriched uranium will also be pertinent in considering the degrees and frequency of access to the cascade areas of centrifuge enrichment plants. This report describes the process for combining technical measures, implementation approaches and objectives to arrive at the total number of theoretically possible combinations. It then describes how these combinations may be reduced in a series of steps to a number that is more manageable for detailed evaluation. The process is shown schematically.

  19. Expediting environmental cleanup--nationwide stakeholder involvement in U.S. Department of Energy`s plume focus area

    SciTech Connect (OSTI)

    McCabe, G.H.; Stein, S.L.; Serie, P.J.

    1995-12-01

    The U.S. Department of Energy (DOE) faces a major challenge in cleaning up its contaminated sites throughout the United States. One major area of concern is the plumes in soil and ground water, contaminated with a myriad of different pollutants. DOE recently established the Plume Focus Area to address these problems. The mission of the Plume Focus Area is to enhance the deployment of innovative technologies for containing and cleaning up contaminant plumes in ground water and soil at all DOE sites. By involving a range of stakeholders in the selection, demonstration, and evaluation of new technologies, the deployment of these technologies can be enhanced. Through this strategy, technology users join with other stakeholders to assess the appropriateness of new technologies for addressing plume contamination, and characterize the conditions under which those emerging technologies will be acceptable. If new plume cleanup technologies are to be deployable, they must improve on today`s baseline technologies. If sites and their stakeholders understood the technologies, recognize that their concerns are reflected in the evaluations and demonstrations, and participate in assessing how technology performance addresses their concerns, the likelihood of acceptance of those technologies is greater. Thus, broad stakeholder acceptance becomes part of the definition of an improved technology, evaluated in parallel with technical performance, cost, and other traditional parameters. This paper further describes the goals and objectives of the Plume Focus Area and emphasizes the importance of stakeholder involvement in achieving them. The process of coordinating with DOE sites is described to highlight how stakeholder input is considered throughout the Plume Focus Area decision-making process in selecting, developing, demonstrating, and evaluating innovative technologies to address plume problems.

  20. Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wagener, R.; Alexandrov, L. B.; Montesinos-Rongen, M.; Schlesner, M.; Haake, A.; Drexler, H. G.; Richter, J.; Bignell, G. R.; McDermott, U.; Siebert, R.

    2015-02-04

    Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or middle-aged males infected with the HIV.1 The clinical outcome of patients with PEL is unfavorable with a median survival of <6 months.1 PEL has been closely associated with human herpes virus 8 (HHV8, previously called Kaposi sarcoma herpesvirus) infection.1 In some cases a coinfection of HHV8 with the Epstein–Barr Virus (EBV) has been described.1 HHV8 encodes various genes homologous to cellular genes that have proliferative and anti-apoptotic functions.2 Although HHV8 is supposed to be a major driver ofmore » PEL, it alone is not sufficient for a full-blown lymphomagenesis.2 PEL usually shows complex karyotypes with many chromosomal aberrations.3 This chromosomal complexity might be driven by the viral infection and lead to genetic alterations cooperating with HHV8 in PEL lymphomagenesis.4« less

  1. Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

    SciTech Connect (OSTI)

    Wagener, R.; Alexandrov, L. B.; Montesinos-Rongen, M.; Schlesner, M.; Haake, A.; Drexler, H. G.; Richter, J.; Bignell, G. R.; McDermott, U.; Siebert, R.

    2015-02-04

    Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or middle-aged males infected with the HIV.1 The clinical outcome of patients with PEL is unfavorable with a median survival of <6 months.1 PEL has been closely associated with human herpes virus 8 (HHV8, previously called Kaposi sarcoma herpesvirus) infection.1 In some cases a coinfection of HHV8 with the Epstein–Barr Virus (EBV) has been described.1 HHV8 encodes various genes homologous to cellular genes that have proliferative and anti-apoptotic functions.2 Although HHV8 is supposed to be a major driver of PEL, it alone is not sufficient for a full-blown lymphomagenesis.2 PEL usually shows complex karyotypes with many chromosomal aberrations.3 This chromosomal complexity might be driven by the viral infection and lead to genetic alterations cooperating with HHV8 in PEL lymphomagenesis.4

  2. Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich peptide and methionine sulfoxide reductase

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Melnyk, Ryan A.; Youngblut, Matthew D.; Clark, Iain C.; Carlson, Hans K.; Wetmore, Kelly M.; Price, Morgan N.; Lavarone, Anthony T.; Deutschbauer, Adam M.; Arkin, Adam P.; Coates, John D.

    2015-05-12

    Reactive chlorine species (RCS) defense mechanisms are important for bacterial fitness in diverse environments. In addition to the anthropogenic use of RCS in the form of bleach, these compounds are also produced naturally through photochemical reactions of natural organic matter and in vivo by the mammalian immune system in response to invading microorganisms. To gain insight into bacterial RCS defense mechanisms, we investigated Azospira suillum strain PS, which produces periplasmic RCS as an intermediate of perchlorate respiration. Our studies identified an RCS response involving an RCS stress-sensing sigma/anti-sigma factor system (SigF/NrsF), a soluble hypochlorite-scavenging methionine-rich periplasmic protein (MrpX), and amore » putative periplasmic methionine sulfoxide reductase (YedY1). We investigated the underlying mechanism by phenotypic characterization of appropriate gene deletions, chemogenomic profiling of barcoded transposon pools, transcriptome sequencing, and biochemical assessment of methionine oxidation. Our results demonstrated that SigF was specifically activated by RCS and initiated the transcription of a small regulon centering around yedY1 and mrpX. A yedY1 paralog (yedY2) was found to have a similar fitness to yedY1 despite not being regulated by SigF. Markerless deletions of yedY2 confirmed its synergy with the SigF regulon. MrpX was strongly induced and rapidly oxidized by RCS, especially hypochlorite. Our results suggest a mechanism involving hypochlorite scavenging by sacrificial oxidation of the MrpX in the periplasm. Reduced MrpX is regenerated by the YedY methionine sulfoxide reductase activity. The phylogenomic distribution of this system revealed conservation in several Proteobacteria of clinical importance, including uropathogenic Escherichia coli and Brucella spp., implying a putative role in immune response evasion in vivo. In addition, bacteria are often stressed in the environment by reactive chlorine species (RCS) of

  3. Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich peptide and methionine sulfoxide reductase

    SciTech Connect (OSTI)

    Melnyk, Ryan A.; Youngblut, Matthew D.; Clark, Iain C.; Carlson, Hans K.; Wetmore, Kelly M.; Price, Morgan N.; Lavarone, Anthony T.; Deutschbauer, Adam M.; Arkin, Adam P.; Coates, John D.

    2015-05-12

    Reactive chlorine species (RCS) defense mechanisms are important for bacterial fitness in diverse environments. In addition to the anthropogenic use of RCS in the form of bleach, these compounds are also produced naturally through photochemical reactions of natural organic matter and in vivo by the mammalian immune system in response to invading microorganisms. To gain insight into bacterial RCS defense mechanisms, we investigated Azospira suillum strain PS, which produces periplasmic RCS as an intermediate of perchlorate respiration. Our studies identified an RCS response involving an RCS stress-sensing sigma/anti-sigma factor system (SigF/NrsF), a soluble hypochlorite-scavenging methionine-rich periplasmic protein (MrpX), and a putative periplasmic methionine sulfoxide reductase (YedY1). We investigated the underlying mechanism by phenotypic characterization of appropriate gene deletions, chemogenomic profiling of barcoded transposon pools, transcriptome sequencing, and biochemical assessment of methionine oxidation. Our results demonstrated that SigF was specifically activated by RCS and initiated the transcription of a small regulon centering around yedY1 and mrpX. A yedY1 paralog (yedY2) was found to have a similar fitness to yedY1 despite not being regulated by SigF. Markerless deletions of yedY2 confirmed its synergy with the SigF regulon. MrpX was strongly induced and rapidly oxidized by RCS, especially hypochlorite. Our results suggest a mechanism involving hypochlorite scavenging by sacrificial oxidation of the MrpX in the periplasm. Reduced MrpX is regenerated by the YedY methionine sulfoxide reductase activity. The phylogenomic distribution of this system revealed conservation in several Proteobacteria of clinical importance, including uropathogenic Escherichia coli and Brucella spp., implying a putative role in immune response evasion in vivo. In addition, bacteria are often

  4. DOE Partnerships with States, Tribes and Other Federal Programs Help Responders Prepare for Challenges Involving Transport of Radioactive Materials

    SciTech Connect (OSTI)

    Marsha Keister

    2001-02-01

    DOE Partnerships with States, Tribes and Other Federal Programs Help Responders Prepare for Challenges Involving Transport of Radioactive Materials Implementing adequate institutional programs and validating preparedness for emergency response to radiological transportation incidents along or near U.S. Department of Energy (DOE) shipping corridors poses unique challenges to transportation operations management. Delayed or insufficient attention to State and Tribal preparedness needs may significantly impact the transportation operations schedule and budget. The DOE Transportation Emergency Preparedness Program (TEPP) has successfully used a cooperative planning process to develop strong partnerships with States, Tribes, Federal agencies and other national programs to support responder preparedness across the United States. DOE TEPP has found that building solid partnerships with key emergency response agencies ensures responders have access to the planning, training, technical expertise and assistance necessary to safely, efficiently and effectively respond to a radiological transportation accident. Through the efforts of TEPP over the past fifteen years, partnerships have resulted in States and Tribal Nations either using significant portions of the TEPP planning resources in their programs and/or adopting the Modular Emergency Response Radiological Transportation Training (MERRTT) program into their hazardous material training curriculums to prepare their fire departments, law enforcement, hazardous materials response teams, emergency management officials, public information officers and emergency medical technicians for responding to transportation incidents involving radioactive materials. In addition, through strong partnerships with Federal Agencies and other national programs TEPP provided technical expertise to support a variety of radiological response initiatives and assisted several programs with integration of the nationally recognized MERRTT program

  5. Ewald Summation Approach to Potential Models of Aqueous Electrolytes Involving Gaussian Charges and Induced Dipoles: Formal and Simulation Results

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chialvo, Ariel A.; Vlcek, Lukas

    2014-11-01

    We present a detailed derivation of the complete set of expressions required for the implementation of an Ewald summation approach to handle the long-range electrostatic interactions of polar and ionic model systems involving Gaussian charges and induced dipole moments with a particular application to the isobaricisothermal molecular dynamics simulation of our Gaussian Charge Polarizable (GCP) water model and its extension to aqueous electrolytes solutions. The set comprises the individual components of the potential energy, electrostatic potential, electrostatic field and gradient, the electrostatic force and the corresponding virial. Moreover, we show how the derived expressions converge to known point-based electrostatic counterpartsmore » when the parameters, defining the Gaussian charge and induced-dipole distributions, are extrapolated to their limiting point values. Finally, we illustrate the Ewald implementation against the current reaction field approach by isothermal-isobaric molecular dynamics of ambient GCP water for which we compared the outcomes of the thermodynamic, microstructural, and polarization behavior.« less

  6. G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis

    SciTech Connect (OSTI)

    Shi, Yanan; Liu, Xiaochun; Zhu, Pei; Li, Jianzhen; Sham, Kathy W.Y.; Cheng, Shuk Han; Li, Shuisheng; Zhang, Yong; Cheng, Christopher H.K.; Lin, Haoran

    2013-05-24

    Highlights: •The Gper expression was detected in the developing brain of zebrafish. •Gper morpholino knockdown induced apoptosis of brain cells. •Gper morpholino knockdown reduced expression in neuron markers. •Zebrafish Gper may be involved in neuronal development. -- Abstract: G-protein-coupled estrogen receptor 1 (Gper, formerly known as GPR30) is found to be a trophic and protective factor in mediating action of estrogen in adult brain, while its role in developing brain remains to be elucidated. Here we present the expression pattern of Gper and its functions during embryogenesis in zebrafish. Both the mRNA and protein of Gper were detected throughout embryogenesis. Whole mount in situ hybridization (WISH) revealed a wide distribution of gper mRNAs in various regions of the developing brain. Gper knockdown by specific morpholinos resulted in growth retardation in embryos and morphological defects in the developing brain. In addition, induced apoptosis, decreased proliferation of the brain cells and maldevelopment of sensory and motor neurons were also found in the morphants. Our results provide novel insights into Gper functions in the developing brain, revealing that Gper can maintain the survival of the brain cells, and formation and/or differentiation of the sensory and motor neurons.

  7. Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

    SciTech Connect (OSTI)

    Lai, Serene R.; Cunningham, Amanda P.; Huynh, Vu Q.; Andrews, Lucy G.; Tollefsbol, Trygve O. . E-mail: trygve@uab.edu

    2007-01-15

    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cycle and on its own regulatory proteins, specifically: p53 and p21. We tested our hypothesis that hTERT regulates its own expression through effects on upstream regulatory genes using transformed human embryonic kidney (HEK 293) cells, p53 and p16 {sup INK4a} null human ovarian cancer SKOV-3 cells, and p53-null MDA-MB-157 human mammary cancer cells. In HEK 293 cells, hTERT knockdown resulted in elevated p53 and p21 transcription and a decrease in cellular proliferation. Similar results were observed in the MDA-MB-157 cell line where p21 was upregulated, correlating with cell growth inhibition. In contrast, we observed a decrease in expression of p21 in SKOV-3 cells with hTERT knockdown and cell growth appeared to be unaffected. These findings suggest that hTERT may be involved in a feedback loop system, thereby playing a role in its own regulation.

  8. Visible light stimulating dual-wavelength emission and O vacancy involved energy transfer behavior in luminescence for coaxial nanocable arrays

    SciTech Connect (OSTI)

    Yang, Lei, E-mail: nanoyang@qq.com [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Hunan Province Key Laboratory for Spray Deposition Technology and Application, Hunan University, Changsha 410082 (China); Dong, Jiazhang; Jiang, Zhongcheng [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Pan, Anlian; Zhuang, Xiujuan [Key Laboratory for Micro-Nano Physics and Technology of Hunan Province, Hunan University, Changsha 410082 (China)

    2014-06-14

    We report a strategy to investigate O vacancy (V{sub O}) involved energy transfer and dual-wavelength yellow emission in coaxial nanocable. By electric field deposition and subsequent sol-gel template approach, ZnO:Tb/Y{sub 2}O{sub 3}:Eu coaxial nanocable arrays are synthesized. After visible light excitation, system is promoted to O vacancy charge transfer state of V{sub O}(0/+). In the following cross relaxation, energy transfer from V{sub O} to the excitation energy level of Tb{sup 3+} in ZnO:Tb core area. While in Y{sub 2}O{sub 3}:Eu shell area, energy transfer to the excitation energy level of Eu{sup 3+}. Subsequently, dual-wavelength emission is observed. By constructing nanocable with dual-wavelength emission, yellow luminescence is obtained. Adjust doping concentration of Eu{sup 3+} or Tb{sup 3+} in the range of 0.010.05, chromaticity coordinates of ZnO:Tb/Y{sub 2}O{sub 3}:Eu nanocable stably stays at yellow region in color space except ZnO:Tb{sub 0.01}/Y{sub 2}O{sub 3}:Eu{sub 0.01}. As Vo states act as media in energy transfer process in nanocablers, visible light can stimulate dual-wavelength emissions. Yellow luminescent nanocable arrays will have great applications in light-emitting diode luminescence.

  9. Three necessary conditions for progress in low-level waste management: Political commitment, managerial skill, and public involvement

    SciTech Connect (OSTI)

    Wiltshire, S.

    1989-11-01

    Since the late 1970`s many people have worked hard to resolve the question of how this nation will manage its low-level radioactive waste. However, many problems persist. No new disposal facilities have been built since the early 1970`s and some states do not appear to be making much headway on the problem. The current alignment of states in compacts may lead to the designation of more sites than necessary, thus wasting resources and sites that might be used for something else and causing dissension and disruption in more communities than is really necessary. However, progress has been made: low-level waste is on the political agenda in an effective way in many states; much more management attention and skill are being devoted to waste management; and more experience has increased the understanding and skill necessary for management and government officials to be able to involve the public effectively in waste management decision-making. What conditions have produced this progress? What has been learned from ten years of work on the problem? How can these lessons be applied to future decisions, including those about the cleanup and isolation of defense waste? The paper attempts to answer these questions.

  10. H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove

    SciTech Connect (OSTI)

    Walter, W.; Loos, M.; Maeurer, M.J.

    1996-12-31

    The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibility I-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequenced H2-Ma, H2-Mb1, and H2-Mb2 genes from CIA-susceptible and -resistant mouse strains and identified four different Ma and Mb2 alleles, and three different Mb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share common Ma, Mb1, and Mb2 alleles. In contrast, H2-M alleles designated Ma-III, Ma-IV, Mb1-III, and Mb2-IV could be exclusively identified in the CIA-susceptible H2{sup r} and H2{sup q} haplotypes, suggesting that allelic H2-M molecules may modulate the composition of different CII peptides loaded onto MHC class II molecules, presumably presenting {open_quotes}arthritogenic{close_quotes} epitopes to T lymphocytes. 42 refs., 4 figs., 3 tabs.

  11. Nuclear substructure reorganization during late stageerythropoiesis is selective and does not involve caspase cleavage ofmajor nuclear substructural proteins

    SciTech Connect (OSTI)

    Krauss, Sharon Wald; Lo, Annie J.; Short, Sarah A.; Koury, MarkJ.; Mohandas, Narla; Chasis, Joel Anne

    2005-04-06

    Enucleation, a rare feature of mammalian differentiation, occurs in three cell types: erythroblasts, lens epithelium and keratinocytes. Previous investigations suggest that caspase activation functions in lens epithelial and keratinocyte enucleation, as well as in early erythropoiesis encompassing BFU-E differentiation to proerythroblast. To determine whether caspase activation contributes to later erythropoiesis and whether nuclear substructures other than chromatin reorganize, we analyzed distributions of nuclear subcompartment proteins and assayed for caspase-induced cleavage of subcompartmental target proteins in mouse erythroblasts. We found that patterns of lamin B in the filamentous network interacting with both the nuclear envelope and DNA, nuclear matrix protein NuMA, and splicing factors Sm and SC35 persisted during nuclear condensation, consistent with effective transcription of genes expressed late in differentiation. Thus nuclear reorganization prior to enucleation is selective, allowing maintenance of critical transcriptional processes independent of extensive chromosomal reorganization. Consistent with these data, we found no evidence for caspase-induced cleavage of major nuclear subcompartment proteins during late erythropoiesis, in contrast to what has been observed in early erythropoiesis and in lens epithelial and keratinocyte differentiation. These findings imply that nuclear condensation and extrusion during terminal erythroid differentiation involve novel mechanisms that do not entail major activation of apoptotic machinery.

  12. Findings of an evaluation of public involvement programs associated with the development of a Land and Resource Management Plan for the Ouachita National Forest

    SciTech Connect (OSTI)

    Holthoff, M.G.; Howell, R.E.

    1993-08-01

    Federal regulations require the United States Forest Service (USFS) to integrate public input and values into decisions concerning land and resource management planning. The USFS has typically relied on traditional methods of involving the public, whereby public access and input to policy development are unilaterally controlled by the agency. Because of the highly political nature of land and resource management planning, such technocratic forms of public involvement and decision-making appear to be proving ineffective. This paper describes and evaluates two public involvement programs associated with the Ouachita National Forest`s (ONF) lengthy forest planning process. The research consisted of personal interviews with key program leaders and knowledgeable citizen participants, collection of secondary data, and a survey of citizen participants. Because of controversial planning decisions made during an initial planning process, the ONF was forced to re-enter the planning process in order to address unresolved planning issues and to conduct a more effective public involvement program. The supplemental planning process also resulted in a considerable degree of public contention. The survey revealed that although citizen participants were somewhat more satisfied with the supplemental public involvement program relative to the initial program, neither program was viewed as satisfactory. The findings of the study suggest that in order to be more effective, USFS public involvement programs should be more responsive to public concerns and conducted in adherence to principles of collaborative planning.

  13. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1

    SciTech Connect (OSTI)

    Kar, Rekha; Department of Biochemistry, UT Health Science Center at San Antonio, San Antonio, TX 78229 ; Mishra, Nandita; Singha, Prajjal K.; Venkatachalam, Manjeri A.; Department of Biochemistry, UT Health Science Center at San Antonio, San Antonio, TX 78229 ; Saikumar, Pothana

    2010-09-03

    Research highlights: {yields} Chemical inhibition of fission protein Drp1 leads to mitochondrial fusion. {yields} Increased fusion stimulates molecular changes in mitochondrial fusion protein OPA1. {yields} Proteolysis of larger isoforms, new synthesis and ubiquitination of OPA1 occur. {yields} Loss of mitochondrial tubular rigidity and disorganization of cristae. {yields} Generation of large swollen dysfunctional mitochondria. -- Abstract: We showed earlier that 15 deoxy {Delta}{sup 12,14} prostaglandin J2 (15d-PGJ2) inactivates Drp1 and induces mitochondrial fusion . However, prolonged incubation of cells with 15d-PGJ2 resulted in remodeling of fused mitochondria into large swollen mitochondria with irregular cristae structure. While initial fusion of mitochondria by 15d-PGJ2 required the presence of both outer (Mfn1 and Mfn2) and inner (OPA1) mitochondrial membrane fusion proteins, later mitochondrial changes involved increased degradation of the fusion protein OPA1 and ubiquitination of newly synthesized OPA1 along with decreased expression of Mfn1 and Mfn2, which likely contributed to the loss of tubular rigidity, disorganization of cristae, and formation of large swollen degenerated dysfunctional mitochondria. Similar to inhibition of Drp1 by 15d-PGJ2, decreased expression of fission protein Drp1 by siRNA also resulted in the loss of fusion proteins. Prevention of 15d-PGJ2 induced mitochondrial elongation by thiol antioxidants prevented not only loss of OPA1 isoforms but also its ubiquitination. These findings provide novel insights into unforeseen complexity of molecular events that modulate mitochondrial plasticity.

  14. Role of FDG-PET in the Implementation of Involved-Node Radiation Therapy for Hodgkin Lymphoma Patients

    SciTech Connect (OSTI)

    Girinsky, Théodore; Aupérin, Anne; Ribrag, Vincent; Elleuch, Manel; Fermé, Christophe; Bonniaud, Guillaume; Ruelle, Claude; Alberini, Jean-Louis; Celebic, Aljosa; Edeline, Véronique

    2014-08-01

    Purpose: This study examines the role of {sup 18}F-labeled fluorodeoxyglucose positron emission tomography (FDG-PET) in the implementation of involved-node radiation therapy (INRT) in patients treated for clinical stages (CS) I/II supradiaphragmatic Hodgkin lymphoma (HL). Methods and Material: Patients with untreated CS I/II HL enrolled in the randomized EORTC/LYSA/FIL Intergroup H10 trial and participating in a real-time prospective quality assurance program were prospectively included in this study. Data were electronically obtained from 18 French cancer centers. All patients underwent APET-computed tomography (PET-CT) and a post-chemotherapy planning CT scanning. The pre-chemotherapy gross tumor volume (GTV) and the postchemotherapy clinical target volume (CTV) were first delineated on CT only by the radiation oncologist. The planning PET was then co-registered, and the delineated volumes were jointly analyzed by the radiation oncologist and the nuclear medicine physician. Lymph nodes undetected on CT but FDG-avid were recorded, and the previously determined GTV and CTV were modified according to FDG-PET results. Results: From March 2007 to February 2010, 135 patients were included in the study. PET-CT identified at least 1 additional FDG-avid lymph node in 95 of 135 patients (70.4%; 95% confidence interval [CI]: 61.9%-77.9%) and 1 additional lymph node area in 55 of 135 patients (40.7%; 95% CI: 32.4%-49.5%). The mean increases in the GTV and CTV were 8.8% and 7.1%, respectively. The systematic addition of PET to CT led to a CTV increase in 60% of the patients. Conclusions: Pre-chemotherapy FDG-PET leads to significantly better INRT delineation without necessarily increasing radiation volumes.

  15. Proteomic analysis reveals metabolic and regulatory systems involved in the syntrophic and axenic lifestyle of Syntrophomonas wolfei

    SciTech Connect (OSTI)

    Sieber, Jessica R.; Crable, Bryan R.; Sheik, Cody S.; Hurst, Gregory B.; Rohlin, Lars; Gunsalus, Robert P.; McInerney, Michael J.

    2015-02-11

    We report that microbial syntrophy is a vital metabolic interaction necessary for the complete oxidation of organic biomass to methane in all-anaerobic ecosystems. However, this process is thermodynamically constrained and represents an ecosystem-level metabolic bottleneck. To gain insight into the physiology of this process, a shotgun proteomics approach was used to quantify the protein landscape of the model syntrophic metabolizer, Syntrophomonas wolfei, grown axenically and syntrophically with Methanospirillum hungatei. Remarkably, the abundance of most proteins as represented by normalized spectral abundance factor (NSAF) value changed very little between the pure and coculture growth conditions. Among the most abundant proteins detected were GroEL and GroES chaperonins, a small heat shock protein, and proteins involved in electron transfer, beta-oxidation, and ATP synthesis. Several putative energy conservation enzyme systems that utilize NADH and ferredoxin were present. The abundance of an EtfAB2 and the membrane-bound iron-sulfur oxidoreductase (Swol_0698 gene product) delineated a potential conduit for electron transfer between acyl-CoA dehydrogenases and membrane redox carriers. Proteins detected only when S. wolfei was grown with M. hungatei included a zinc-dependent dehydrogenase with a GroES domain, whose gene is present in genomes in many organisms capable of syntrophy, and transcriptional regulators responsive to environmental stimuli or the physiological status of the cell. In conclusion, the proteomic analysis revealed an emphasis on macromolecular stability and energy metabolism by S. wolfei and presence of regulatory mechanisms responsive to external stimuli and cellular physiological status.

  16. Proteomic analysis reveals metabolic and regulatory systems involved in the syntrophic and axenic lifestyle of Syntrophomonas wolfei

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sieber, Jessica R.; Crable, Bryan R.; Sheik, Cody S.; Hurst, Gregory B.; Rohlin, Lars; Gunsalus, Robert P.; McInerney, Michael J.

    2015-02-11

    We report that microbial syntrophy is a vital metabolic interaction necessary for the complete oxidation of organic biomass to methane in all-anaerobic ecosystems. However, this process is thermodynamically constrained and represents an ecosystem-level metabolic bottleneck. To gain insight into the physiology of this process, a shotgun proteomics approach was used to quantify the protein landscape of the model syntrophic metabolizer, Syntrophomonas wolfei, grown axenically and syntrophically with Methanospirillum hungatei. Remarkably, the abundance of most proteins as represented by normalized spectral abundance factor (NSAF) value changed very little between the pure and coculture growth conditions. Among the most abundant proteins detectedmore » were GroEL and GroES chaperonins, a small heat shock protein, and proteins involved in electron transfer, beta-oxidation, and ATP synthesis. Several putative energy conservation enzyme systems that utilize NADH and ferredoxin were present. The abundance of an EtfAB2 and the membrane-bound iron-sulfur oxidoreductase (Swol_0698 gene product) delineated a potential conduit for electron transfer between acyl-CoA dehydrogenases and membrane redox carriers. Proteins detected only when S. wolfei was grown with M. hungatei included a zinc-dependent dehydrogenase with a GroES domain, whose gene is present in genomes in many organisms capable of syntrophy, and transcriptional regulators responsive to environmental stimuli or the physiological status of the cell. In conclusion, the proteomic analysis revealed an emphasis on macromolecular stability and energy metabolism by S. wolfei and presence of regulatory mechanisms responsive to external stimuli and cellular physiological status.« less

  17. The Small Ethylene Response Factor ERF96 is Involved in the Regulation of the Abscisic Acid Response in Arabidopsis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Xiaoping; Liu, Shanda; Tian, Hainan; Wang, Shucai; Chen, Jin-Gui

    2015-11-26

    Ethylene regulates many aspects of plant growth and development including seed germination, leaf senescence, and fruit ripening, and of plant responses to environmental stimuli including both biotic and abiotic stresses. Ethylene response factors (ERFs) are plant-specific transcription factors and are a subfamily of the AP2 (APETALA2)/ERF transcription factor family. The function of many members in this large gene family remains largely unknown. ERF96, a member of the Group IX ERF family transcription factors, has recently been shown to be a transcriptional activator that is involved in plant defense response in Arabidopsis. In this article, we provide evidence that ERF96 ismore » a positive regulator of abscisic acid (ABA) responses. Bioinformatics analysis indicated that there are a total four small ERFs in Arabidopsis including ERF95, ERF96, ERF97, and ERF98, and that ERF96 forms a cluster with ERF95 and ERF97. By using quantitative RT-PCR, we found that ERF96 is expressed in all tissues and organs examined except roots, with relatively high expression in flowers and seeds. Results from the protoplast transfection assay indicated that the EDLL motif-containing C-terminal domain is responsible for ERF96’s transcriptional activity. Although loss-of-function mutant of ERF96 was morphologically similar to wild type plants, transgenic plants overexpressing ERF96 had smaller rosette size and were delayed in flowering time. In ABA sensitivity assays, we found that ERF96 overexpression plants were hypersensitive to ABA in terms of ABA inhibition of seed germination, early seedling development and root elongation. Consistent with these observations, elevated transcript levels of some ABA-responsive genes including RD29A, ABI5, ABF3, ABF4, P5CS, and COR15A were observed in the transgenic plants in the presence of ABA. However, in the absence of ABA treatment, the transcript levels of these ABA-responsive genes remained largely unchanged. Our experiments also showed

  18. The Small Ethylene Response Factor ERF96 is Involved in the Regulation of the Abscisic Acid Response in Arabidopsis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Xiaoping; Liu, Shanda; Tian, Hainan; Wang, Shucai; Chen, Jin-Gui

    2015-11-26

    We report that ethylene regulates many aspects of plant growth and development including seed germination, leaf senescence, and fruit ripening, and of plant responses to environmental stimuli including both biotic and abiotic stresses. Ethylene response factors (ERFs) are plant-specific transcription factors and are a subfamily of the AP2 (APETALA2)/ERF transcription factor family. The function of many members in this large gene family remains largely unknown. ERF96, a member of the Group IX ERF family transcription factors, has recently been shown to be a transcriptional activator that is involved in plant defense response in Arabidopsis. Here we provide evidence that ERF96more » is a positive regulator of abscisic acid (ABA) responses. Bioinformatics analysis indicated that there are a total four small ERFs in Arabidopsis including ERF95, ERF96, ERF97, and ERF98, and that ERF96 forms a cluster with ERF95 and ERF97. By using quantitative RT-PCR, we found that ERF96 is expressed in all tissues and organs examined except roots, with relatively high expression in flowers and seeds. Results from the protoplast transfection assay indicated that the EDLL motif-containing C-terminal domain is responsible for ERF96’s transcriptional activity. Although loss-of-function mutant of ERF96 was morphologically similar to wild type plants, transgenic plants overexpressing ERF96 had smaller rosette size and were delayed in flowering time. In ABA sensitivity assays, we found that ERF96 overexpression plants were hypersensitive to ABA in terms of ABA inhibition of seed germination, early seedling development and root elongation. Consistent with these observations, elevated transcript levels of some ABA-responsive genes including RD29A, ABI5, ABF3, ABF4, P5CS, and COR15A were observed in the transgenic plants in the presence of ABA. However, in the absence of ABA treatment, the transcript levels of these ABA-responsive genes remained largely unchanged. Our experiments also showed

  19. The Small Ethylene Response Factor ERF96 is Involved in the Regulation of the Abscisic Acid Response in Arabidopsis

    SciTech Connect (OSTI)

    Wang, Xiaoping; Liu, Shanda; Tian, Hainan; Wang, Shucai; Chen, Jin-Gui

    2015-11-26

    We report that ethylene regulates many aspects of plant growth and development including seed germination, leaf senescence, and fruit ripening, and of plant responses to environmental stimuli including both biotic and abiotic stresses. Ethylene response factors (ERFs) are plant-specific transcription factors and are a subfamily of the AP2 (APETALA2)/ERF transcription factor family. The function of many members in this large gene family remains largely unknown. ERF96, a member of the Group IX ERF family transcription factors, has recently been shown to be a transcriptional activator that is involved in plant defense response in Arabidopsis. Here we provide evidence that ERF96 is a positive regulator of abscisic acid (ABA) responses. Bioinformatics analysis indicated that there are a total four small ERFs in Arabidopsis including ERF95, ERF96, ERF97, and ERF98, and that ERF96 forms a cluster with ERF95 and ERF97. By using quantitative RT-PCR, we found that ERF96 is expressed in all tissues and organs examined except roots, with relatively high expression in flowers and seeds. Results from the protoplast transfection assay indicated that the EDLL motif-containing C-terminal domain is responsible for ERF96’s transcriptional activity. Although loss-of-function mutant of ERF96 was morphologically similar to wild type plants, transgenic plants overexpressing ERF96 had smaller rosette size and were delayed in flowering time. In ABA sensitivity assays, we found that ERF96 overexpression plants were hypersensitive to ABA in terms of ABA inhibition of seed germination, early seedling development and root elongation. Consistent with these observations, elevated transcript levels of some ABA-responsive genes including RD29A, ABI5, ABF3, ABF4, P5CS, and COR15A were observed in the transgenic plants in the presence of ABA. However, in the absence of ABA treatment, the transcript levels of these ABA-responsive genes remained largely unchanged. Our experiments also showed that

  20. An extracytoplasmic function sigma factor-dependent periplasmic glutathione peroxidase is involved in oxidative stress response of Shewanella oneidensis

    SciTech Connect (OSTI)

    Dai, Jingcheng; Wei, Hehong; Tian, Chunyuan; Damron, Fredrick; Zhou, Jizhong; Qiu, Dongru

    2015-01-01

    Background: Bacteria use alternative sigma factors (σs) to regulate condition-specific gene expression for survival and Shewanella harbors multiple ECF (extracytoplasmic function) σ genes and cognate anti-sigma factor genes. Here we comparatively analyzed two of the rpoE-like operons in the strain MR-1: rpoE-rseA-rseB-rseC and rpoE2-chrR. Results: RpoE was important for bacterial growth at low and high temperatures, in the minimal medium, and high salinity. The degP/htrA orthologue, required for growth of Escherichia coli and Pseudomonas aeruginosa at high temperature, is absent in Shewanella, while the degQ gene is RpoE-regulated and is required for bacterial growth at high temperature. RpoE2 was essential for the optimal growth in oxidative stress conditions because the rpoE2 mutant was sensitive to hydrogen peroxide and paraquat. The operon encoding a ferrochelatase paralogue (HemH2) and a periplasmic glutathione peroxidase (PgpD) was identified as RpoE2-dependent. PgpD exhibited higher activities and played a more important role in the oxidative stress responses than the cytoplasmic glutathione peroxidase CgpD under tested conditions. The rpoE2-chrR operon and the identified regulon genes, including pgpD and hemH2, are coincidently absent in several psychrophilic and/or deep-sea Shewanella strains. Conclusion: In S. oneidensis MR-1, the RpoE-dependent degQ gene is required for optimal growth under high temperature. The rpoE2 and RpoE2-dependent pgpD gene encoding a periplasmic glutathione peroxidase are involved in oxidative stress responses. But rpoE2 is not required for bacterial growth at low temperature and it even affected bacterial growth under salt stress, indicating that there is a tradeoff between the salt resistance and RpoE2-mediated oxidative stress responses.

  1. An extracytoplasmic function sigma factor-dependent periplasmic glutathione peroxidase is involved in oxidative stress response of Shewanella oneidensis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dai, Jingcheng; Wei, Hehong; Tian, Chunyuan; Damron, Fredrick; Zhou, Jizhong; Qiu, Dongru

    2015-01-01

    Background: Bacteria use alternative sigma factors (σs) to regulate condition-specific gene expression for survival and Shewanella harbors multiple ECF (extracytoplasmic function) σ genes and cognate anti-sigma factor genes. Here we comparatively analyzed two of the rpoE-like operons in the strain MR-1: rpoE-rseA-rseB-rseC and rpoE2-chrR. Results: RpoE was important for bacterial growth at low and high temperatures, in the minimal medium, and high salinity. The degP/htrA orthologue, required for growth of Escherichia coli and Pseudomonas aeruginosa at high temperature, is absent in Shewanella, while the degQ gene is RpoE-regulated and is required for bacterial growth at high temperature. RpoE2 was essentialmore » for the optimal growth in oxidative stress conditions because the rpoE2 mutant was sensitive to hydrogen peroxide and paraquat. The operon encoding a ferrochelatase paralogue (HemH2) and a periplasmic glutathione peroxidase (PgpD) was identified as RpoE2-dependent. PgpD exhibited higher activities and played a more important role in the oxidative stress responses than the cytoplasmic glutathione peroxidase CgpD under tested conditions. The rpoE2-chrR operon and the identified regulon genes, including pgpD and hemH2, are coincidently absent in several psychrophilic and/or deep-sea Shewanella strains. Conclusion: In S. oneidensis MR-1, the RpoE-dependent degQ gene is required for optimal growth under high temperature. The rpoE2 and RpoE2-dependent pgpD gene encoding a periplasmic glutathione peroxidase are involved in oxidative stress responses. But rpoE2 is not required for bacterial growth at low temperature and it even affected bacterial growth under salt stress, indicating that there is a tradeoff between the salt resistance and RpoE2-mediated oxidative stress responses.« less

  2. The Impact of Extent and Location of Mediastinal Lymph Node Involvement on Survival in Stage III Non-Small Cell Lung Cancer Patients Treated With Definitive Radiotherapy

    SciTech Connect (OSTI)

    Fernandes, Annemarie T.; Mitra, Nandita; Xanthopoulos, Eric; Evans, Tracey; Stevenson, James; Langer, Corey; Kucharczuk, John C.; Lin, Lilie; Rengan, Ramesh

    2012-05-01

    Purpose: Several surgical series have identified subcarinal, contralateral, and multilevel nodal involvement as predictors of poor overall survival in patients with Stage III non-small-cell lung cancer (NSCLC) treated with definitive resection. This retrospective study evaluates the impact of extent and location of mediastinal lymph node (LN) involvement on survival in patients with Stage III NSCLC treated with definitive radiotherapy. Methods and Materials: We analyzed 106 consecutive patients with T1-4 N2-3 Stage III NSCLC treated with definitive radiotherapy at University of Pennsylvania between January 2003 and February 2009. For this analysis, mediastinal LN stations were divided into four mutually exclusive groups: supraclavicular, ipsilateral mediastinum, contralateral mediastinum, and subcarinal. Patients' conditions were then analyzed according to the extent of involvement and location of mediastinal LN stations. Results: The majority (88%) of patients received sequential or concurrent chemotherapy. The median follow-up time for survivors was 32.6 months. By multivariable Cox modeling, chemotherapy use (hazard ratio [HR]: 0.21 [95% confidence interval (CI): 0.07-0.63]) was associated with improved overall survival. Increasing primary tumor [18F]-fluoro-2-deoxy-glucose avidity (HR: 1.11 [CI: 1.06-1.19]), and subcarinal involvement (HR: 2.29 [CI: 1.11-4.73]) were significant negative predictors of overall survival. On univariate analysis, contralateral nodal involvement (HR: 0.70 [CI: 0.33-1.47]), supraclavicular nodal involvement (HR: 0.78 [CI: 0.38-1.67]), multilevel nodal involvement (HR: 0.97 [CI: 0.58-1.61]), and tumor size (HR: 1.04 [CI: 0.94-1.14]) did not predict for overall survival. Patients with subcarinal involvement also had lower rates of 2-year nodal control (51.2% vs. 74.9%, p = 0.047) and 2-year distant control (28.4% vs. 61.2%, p = 0.043). Conclusions: These data suggest that the factors that determine oncologic outcome in Stage III NSCLC

  3. Updating LANL’s Ambient Air Monitoring Network (Airnet)

    SciTech Connect (OSTI)

    Fuehne, David Patrick; Allen, Shannon Purdue

    2015-06-09

    Airnet, LANL's ambient air monitoring for radionuclides, is described both historically as well as the drivers involved in the need for updating the program.

  4. 2016 Tribal Energy and Economic Development February Webinar...

    Energy Savers [EERE]

    about exploring energy markets, wholesale price drivers, and other factors involved in ... Land Commission: the Paragon-Bisti Solar Ranch (3.32 MB) Todd Hegwer, Public Power ...

  5. Visualization/In-situ Analysis Co-Chairs: Laura Monroe, David...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    science involvement * Ability to explore data * Design for end---- users * ... etc) projects are important drivers * Data Movement * Data Reduction o 'Big Data' ...

  6. Oregon Department of Transportation | Open Energy Information

    Open Energy Info (EERE)

    services; transportation safety programs; driver and vehicle licensing; and motor carrier regulation. ODOT is actively involved in developing Oregon's system of...

  7. Adverse Diversity Analysis Guidance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adverse Diversity Analysis Guidance Adverse Diversity Analysis Guidance Attachment 8 - Adverse Diversity Analysis Guidance (124.04 KB) Attachment 8(a) - WFR disparate impact chart example completed (96.18 KB) Attachment 8(b) - WFR disparate impact chart clean (88.56 KB) More Documents & Publications Fact #922: April 25, 2016 Share of Older Population Holding Driver's Licenses is Up and Share of Younger Population Holding Driver's Licenses is Down - Dataset FAIR Act Inventory - FY13 Fayette

  8. Tribal and public involvement in the U.S. Department of Energy Mixed Waste Focus Area -- First quarter status report for the period ending December 31, 1995

    SciTech Connect (OSTI)

    Owens, K.J.

    1996-02-01

    The US Department of Energy (DOE) Mixed Waste Focus Area (MWFA) began operations in February 1995 to provide technologies for the design, construction, and operation of implementable mixed waste treatment systems as identified in DOE Site Treatment Plans of the Federal Facilities Compliance Act. Implementable mixed waste treatment systems means that they meet the MWFA success criteria and that potential barriers to implementing those treatment systems have been identified and eliminated through effective communications and meaningful involvement with regulators, stakeholders, and tribal governments. The Regulatory and External Liaison Product Area of the MWFA is responsible for ensuring that possible teaming arrangements are considered and integrated into the MWFA technology development and decision-making processes. The Tribal and Public Involvement Team of the MWFA Regulatory and External Liaison Product Area has initiated a variety of activities to facilitate tribal and stakeholder involvement within the MWFA. This document discusses the status of those activities as of the end of the first quarter of the 1996 fiscal year and describes applicable lessons learned and process improvements.

  9. An ortholog of farA of Aspergillus nidulans is implicated in the transcriptional activation of genes involved in fatty acid utilization in the yeast Yarrowia lipolytica

    SciTech Connect (OSTI)

    Poopanitpan, Napapol; Kobayashi, Satoshi; Fukuda, Ryouichi; Horiuchi, Hiroyuki; Ohta, Akinori

    2010-11-26

    Research highlights: {yields} POR1 is a Yarrowia lipolytica ortholog of farA involved in fatty acid response in A. nidulans. {yields} Deletion of POR1 caused growth defects on fatty acids. {yields} {Delta}por1 strain exhibited defects in the induction of genes involved in fatty acid utilization. -- Abstract: The yeast Yarrowia lipolytica effectively utilizes hydrophobic substrates such as fatty acids and n-alkanes. To identify a gene(s) regulating fatty acid utilization in Y. lipolytica, we first studied homologous genes to OAF1 and PIP2 of Saccharomyces cerevisiae, but their disruption did not change growth on oleic acid at all. We next characterized a Y. lipolytica gene, POR1 (primary oleate regulator 1), an ortholog of farA encoding a transcriptional activator that regulates fatty acid utilization in Aspergillus nidulans. The deletion mutant of POR1 was defective in the growth on various fatty acids, but not on glucose, glycerol, or n-hexadecane. It exhibited slight defect on n-decane. The transcriptional induction of genes involved in {beta}-oxidation and peroxisome proliferation by oleate was distinctly diminished in the {Delta}por1 strains. These data suggest that POR1 encodes a transcriptional activator widely regulating fatty acid metabolism in Y. lipolytica.

  10. INNOVATIVE TECHNIQUES USED BY EPA, SCDHEC, AND DOE TO INCREASE STAKEHOLDER AND PUBLIC INVOLVEMENT IN THE CLEANUP OF NUCLEAR PRODUCTION FACILITIES

    SciTech Connect (OSTI)

    Mccollum, L

    2007-01-18

    This paper will describe the importance of public and stakeholder involvement to the decisions being made at Savannah River Site (SRS) regarding the cleanup of major production facilities. For over a decade the Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC) have operated under a three party agreement (known as the Federal Facilities Agreement or FFA) to clean up the SRS from the remnants of the Cold War plutonium production at SRS. During this time, the 3 agencies have consulted with the surrounding and impacted public to gain stakeholder input on the decisions concerning the clean up of various wastes at the SRS. The primary instrument of public input has been and remains the SRS Community Advisory Board (CAB). Much progress has been made over the years in cleaning up the SRS and the CAB has provided invaluable stakeholder input. Many planned decisions have been modified and changed as a result of the input of the CAB. Recently, DOE has decided to move forward with the Decommissioning of excess facilities at the SRS. These facilities include many buildings involved in the various missions of radioactive isotope production at the SRS, including the reactors and the plutonium processing facilities. The discussions of the 3 agencies on how to best accomplish this work have always included discussions about how to best involve and receive input from all stakeholders. The innovative way the 3 agencies have worked together through the public involvement format has application nationally and DOE-Complex wide. The decisions made will impact the surrounding community and the country for years. Multiple meetings with the CAB and other stakeholders will be required and it will be incumbent on the 3 agencies to reach out to and involve all interested parties. At least 3 different approaches could be used for stakeholder involvement. (1) a typical CERCLA ''proposed plan

  11. Fundamental Drivers of the Cost and Price of Operating Reserves

    SciTech Connect (OSTI)

    Hummon, M. R.; Denholm, P.; Jorgenson, J.; Palchak, D.; Kirby, B.; Ma, O.

    2013-07-01

    Operating reserves impose a cost on the electric power system by forcing system operators to keep partially loaded spinning generators available for responding to system contingencies variable demand. In many regions of the United States, thermal power plants provide a large fraction of the operating reserve requirement. Alternative sources of operating reserves, such as demand response and energy storage, may provide more efficient sources of these reserves. However, to estimate the potential value of these services, the cost of reserve services under various grid conditions must first be established. This analysis used a commercial grid simulation tool to evaluate the cost and price of several operating reserve services, including spinning contingency reserves and upward regulation reserves. These reserve products were evaluated in a utility system in the western United States, considering different system flexibilities, renewable energy penetration, and other sensitivities. The analysis demonstrates that the price of operating reserves depend highly on many assumptions regarding the operational flexibility of the generation fleet, including ramp rates and the fraction of fleet available to provide reserves.

  12. Fundamental Drivers of the Cost and Price of Operating Reserves

    Broader source: Energy.gov [DOE]

    Operating reserves impose a cost on the electric power system by forcing system operators to keep partially loaded spinning generators available to respond to system contingencies and random variation in demand. Demand response and energy storage, may provide these services at lower cost to conventional generators. However, to estimate the potential value of these services, the cost of reserve services under various grid conditions must first be established. This analysis used a commercial grid simulation tool to evaluate the cost and price of several operating reserve services. These reserve products were evaluated in a utility system in the western United States, considering different system characteristics, renewable energy penetration, and several other sensitivities.

  13. Enhanced Driver Requirements for WIPP Shipments - Fact Sheet

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and pass these training requirements: Radiation worker Dosimetry Public affairsmedia Command and control First responder TRANSCOM Radio communications ...

  14. H- Ion Sources for High Intensity Proton Drivers (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    ... Close Cite: Bibtex Format Close 0 pages in this document matching the terms "" Search For Terms: Enter terms in the toolbar above to search the full text of this document for ...

  15. Beam Loss Studies for Rare Isotope Driver Linacs Final Report

    SciTech Connect (OSTI)

    Wangler, T P; Kurennoy, S S; Billen, J H; Crandall, K R; Qiang, J; Ryne, R D; Mustapha, B; Ostroumov, P; Zhao, Q; York, and R. C.

    2008-03-26

    The Fortran 90 RIAPMTQ/IMPACT code package is a pair of linked beam-dynamics simulation codes that have been developed for end-to-end computer simulations of multiple-charge-state heavy-ion linacs for future exotic-beam facilities. These codes have multiple charge-state capability, and include space-charge forces. The simulations can extend from the low-energy beam-transport line after an ECR ion source to the end of the linac. The work has been performed by a collaboration including LANL, LBNL, ANL, and MSU. The code RIAPMTQ simulates the linac front-end beam dynamics including the LEBT, RFQ, and MEBT. The code IMPACT simulates the beam dynamics of the main superconducting linac. The codes have been benchmarked for rms beam properties against previously existing codes at ANL and MSU. The codes allow high-statistics runs on parallel supercomputing platforms, particularly at NERSC at LBNL, for studies of beam losses. The codes also run on desktop PC computers for low-statistics work. The code package is described in more detail in a recent publication [1] in the Proceedings of PAC07 (2007 US Particle Accelerator Conference). In this report we describe the main activities for the FY07 beam-loss studies project using this code package.

  16. Analyzing Fuel Saving Opportunities through Driver Feedback Mechanisms...

    Broader source: Energy.gov (indexed) [DOE]

    More Documents & Publications Analysis of maximizing the Synergy between PHEVsEVs and PV Defining Real World Drive Cycles to Support APRF Technology Evaluations Real-World PHEV ...

  17. Geochemical drivers of organic matter decomposition in Arctic tundra soils

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Herndon, Elizabeth M.; Yang, Ziming; Graham, David E.; Wullschleger, Stan D.; Gu, Baohua; Liang, Liyuan; Bargar, John; Janot, Noemie; Regier, Tom Z.

    2015-12-07

    Climate change is warming tundra ecosystems in the Arctic, resulting in the decomposition of previously-frozen soil organic matter (SOM) and release of carbon (C) to the atmosphere; however, the processes that control SOM decomposition and C emissions remain highly uncertain. In this study, we evaluate geochemical factors that influence anaerobic production of carbon dioxide (CO2) and methane (CH4) in the active layers of four ice-wedge polygons. Surface and soil pore waters were collected during the annual thaw season over a two-year period in an area containing waterlogged, low-centered polygons and well-drained, high-centered polygons. We report spatial and seasonal patterns ofmore » dissolved gases in relation to the geochemical properties of Fe and organic C as determined using spectroscopic and chromatographic techniques. Iron was present as Fe(II) in soil solution near the permafrost boundary but enriched as Fe(III) in the middle of the active layer, similar to dissolved aromatic-C and organic acids. Dissolved CH4 increased relative to dissolved CO2 with depth and varied with soil moisture in the middle of the active layer in patterns that were positively correlated with the proportion of dissolved Fe(III) in transitional and low-centered polygon soils but negatively correlated in the drier flat- and high-centered polygons. These results suggest that microbial-mediated Fe oxidation and reduction influence respiration/fermentation of SOM and production of substrates (e.g., low-molecular-weight organic acids) for methanogenesis. As a result, we infer that geochemical differences induced by water saturation dictate microbial products of SOM decomposition, and Fe geochemistry is an important factor regulating methanogenesis in anoxic tundra soils.« less

  18. DRIVER TO SUPPORT USE OF NUMERICAL SIMULATION TOOLS

    Energy Science and Technology Software Center (OSTI)

    2001-02-13

    UNIPACK is a computer interface that simplifies and enhances the use of numerical simulation tools to design a primary geometry and/or a forming die for a powder compact and/or to design the pressing process used to shape a powder by compaction. More particularly, it is an interface that utilizes predefined generic geometric configurations to simplify the use of finite element method modeling software to simply and more efficiently design: (1) the shape and size amore » powder compact; (2) a forming die to shape a powder compact; and/or (3) the pressing process used to form a powder compact. UNIPACK is a user interface for a predictive model for powder compaction that incorporates unprecedented flexibility to design powder press tooling and powder pressing processes. UNIPACK works with the Sandia National Laboratories (SNL) Engineering Analysis Cide Access System (SEACAS) to generate a finite element (FE) mesh and automatically perform a FE analysis of powder compaction. UNIPACK was developed to allow a non-expert with minimal training to quickly and easily design/construct a variable dimension component or die in real time on a desktop or laptop personal computer.« less

  19. EXTENDING SODIUM FAST REACTOR DRIVER FUEL USE TO HIGHER TEMPERATURES

    SciTech Connect (OSTI)

    Douglas L. Porter

    2011-02-01

    Calculations of potential sodium-cooled fast reactor fuel temperatures were performed to estimate the effects of increasing the outlet temperature of a given fast reactor design by increasing pin power, decreasing assembly flow, or increasing inlet temperature. Based upon experience in the U.S., both metal and mixed oxide (MOX) fuel types are discussed in terms of potential performance effects created by the increased operating temperatures. Assembly outlet temperatures of 600, 650 and 700 C were used as goal temperatures. Fuel/cladding chemical interaction (FCCI) and fuel melting, as well as challenges to the mechanical integrity of the cladding material, were identified as the limiting phenomena. For example, starting with a recent 1000 MWth fast reactor design, raising the outlet temperature to 650 C through pin power increase increased the MOX centerline temperature to more than 3300 C and the metal fuel peak cladding temperature to more than 700 C. These exceeded limitations to fuel performance; fuel melting was limiting for MOX and FCCI for metal fuel. Both could be alleviated by design fixes, such as using a barrier inside the cladding to minimize FCCI in the metal fuel, or using annular fuel in the case of MOX. Both would also require an advanced cladding material with improved stress rupture properties. While some of these are costly, the benefits of having a high-temperature reactor which can support hydrogen production, or other missions requiring high process heat may make the extra costs justified.

  20. Stand-alone microprocessor controlled fast sweep Langmuir probe driver

    SciTech Connect (OSTI)

    Cheetham, A.D.; Davidson, L.; Jakobsen, J.; Lund, T.; Rayner, J.P.

    1997-09-01

    This article describes a power supply and data logger for a Langmuir probe interfaced to a personal computer. The system provides a voltage sweep range from {minus}125 to +100 V in 100 steps in a time {approximately}0.15 s. Restricted sweep ranges and single point operation are also possible. Probe current measurements are in the range from {minus}1.0 to +100 mA with a precision of 5 {mu}A on the most sensitive range, while the voltage may be set with a precision of 56 mV. Novel features of the system include: the use of integrate-and-dump techniques to implement the process of analog-to-digital conversion and to provide effective noise suppression; a solution to the problem of floating the power supply on top of the potential developed across the grounded current sensing resistor based on the power supply rejection ratio characteristics of a high voltage operational amplifier; and the development of an interface and control board employing the GPIB protocol to communicate with a host computer. Successful operation of the system has been demonstrated in the electrically noisy environment of a helicon plasma source. {copyright} {ital 1997 American Institute of Physics.}

  1. Look-Ahead Driver Feedback and Powertrain Management

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  2. Assessing the Drivers of Regional Trends in Solar Photovoltaic Manufacturing

    Office of Energy Efficiency and Renewable Energy (EERE)

    Using a bottom-up model for wafer-based silicon PV, we examine both historical and future factory-location decisions from the perspective of a multinational corporation. Our model calculates the cost of PV manufacturing with process step resolution, while considering the impact of corporate financing and operations with a calculation of the minimum selling price that provides an adequate rate of return. We quantify the conditions of China's historical PV price advantage, examine if these conditions can be reproduced elsewhere, and evaluate the role of innovative technology in altering regional competitive advantage.

  3. Refueling Behavior of Flexible Fuel Vehicle Drivers in the Federal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    specific commercial product, process, or ... environmental sustainability. Section 701 of the Energy Policy Act (EPAct) 2005 ... at a variety of metrics: percent growth in ...

  4. High-Voltage LED Light Engine with Integrated Driver

    Broader source: Energy.gov [DOE]

    Lead Performer: Lumileds, LLC – San Jose, CADOE Total Funding: $1,499,346Cost Share: $499,783Project Term: 9/1/2014 - 2/29/2016Funding Opportunity: SSL R&D Funding Opportunity Announcement (FOA...

  5. Be a Safe and Efficient Winter Driver | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Drew Bittner WriterEditor, Office of Energy Efficiency and Renewable Energy As I write this post, the Midwest and northern states are in the grip of a deep freeze. Temperatures...

  6. Van Allen probes pinpoint driver of speeding electrons

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    how the acceleration took place. Right now, the team believes that electromagnetic radio waves somehow excite the electrons into a higher-energy state, much like a microwave...

  7. OLED Luminaire with Panel Integrated Drivers and Advanced Controls |

    Broader source: Energy.gov (indexed) [DOE]

    OFFICE OF INSPECTOR GENERAL REPORT ON INSPECTION OF THE SECRETARY OF ENERGY'S FOREIGN TRAVEL Report No: DOE/IG-0397 Office of Inspections Date Issued: October 7, 1996 Washington, D.C. 20585 i REPORT ON INSPECTION OF THE SECRETARY OF ENERGY'S FOREIGN TRAVEL TABLE OF CONTENTS PAGE I. INTRODUCTION AND PURPOSE..................................................................................... 1 II. SCOPE AND

  8. Green Button Gamer: Driver Challenge | Open Energy Information

    Open Energy Info (EERE)

    Device Website: greenbuttongamer.com Web Application Link: greenbuttongamer.com Cost: Free OpenEI Keyword(s): Challenge Generated Green Button Gamer Screenshot References: Green...

  9. H- Ion Sources for High Intensity Proton Drivers

    SciTech Connect (OSTI)

    Johnson, Rolland Paul; Dudnikov, Vadim

    2015-02-20

    Existing RF Surface Plasma Sources (SPS) for accelerators have specific efficiencies for H+ and H- ion generation around 3 to 5 mA/cm2 per kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) SPS described here was developed to improve H- ion production efficiency, reliability and availability for pulsed operation as used in the ORNL Spallation Neutron Source . At low RF power, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm2 per kW of RF power at 13.56 MHz. Initial cesiation of the SPS was performed by heating cesium chromate cartridges by discharge as was done in the very first versions of the SPS. A small oven to decompose cesium compounds and alloys was developed and tested. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA with RF power 1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with 4 kW RF power in the plasma and 250 Gauss longitudinal magnetic field. The ratio of electron current to negative ion current was improved from 30 to 2. Stable generation of H- beam without intensity degradation was demonstrated in the aluminum nitride (AlN) discharge chamber for 32 days at high discharge power in an RF SPS with an external antenna. Some modifications were made to improve the cooling and cesiation stability. The extracted collector current can be increased significantly by optimizing the longitudinal magnetic field in the discharge chamber. While this project demonstrated the advantages of the pulsed version of the SA RF SPS as an upgrade to the ORNL Spallation Neutron Source, it led to a possibility for upgrades to CW machines like the many cyclotrons used for commercial applications. Four appendices contain important details of the work carried out under this grant.

  10. P5 Science Drivers: Accelerator Experiments Panagiotis Spentzouris

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Panagiotis Spentzouris DOE SC Exascale Requirements Reviews: High Energy Physics June 10 th , ... physics beyond the "Standard Model" of HEP has been observed * Neutrinos ...

  11. High Temperature, High Voltage Fully Integrated Gate Driver Circuit

    Broader source: Energy.gov [DOE]

    2010 DOE Vehicle Technologies and Hydrogen Programs Annual Merit Review and Peer Evaluation Meeting, June 7-11, 2010 -- Washington D.C.

  12. Overview of Driver Technologies for Nanosecond Tem Kickers (Conference...

    Office of Scientific and Technical Information (OSTI)

    Report Number(s): SLAC-PUB-16481 DOE Contract Number: AC02-76SF00515 Resource Type: Conference Resource Relation: Conference: Contributed to the 7th International Particle ...

  13. Degradation of EBR-II driver fuel during wet storage

    SciTech Connect (OSTI)

    Pahl, R. G.

    2000-03-09

    Characterization data are reported for sodium bonded EBR-II reactor fuel which had been stored underwater in containers since the 1981--1982 timeframe. Ten stainless steel storage containers, which had leaked water during storage due to improper sealing, were retrieved from the ICPP-603 storage basin at the Idaho National Engineering and Environmental Laboratory (INEEL) in Idaho. In the container chosen for detailed destructive analysis, the stainless steel cladding on the uranium alloy fuel had ruptured and fuel oxide sludge filled the bottom of the container. Headspace gas sampling determined that greater than 99% hydrogen was present. Cesium 137, which had leached out of the fuel during the aqueous corrosion process, dominated the radionuclide source term of the water. The metallic sodium from the fuel element bond had reacted with the water, forming a concentrated caustic solution of NaOH.

  14. Geochemical drivers of organic matter decomposition in Arctic tundra soils

    SciTech Connect (OSTI)

    Herndon, Elizabeth M.; Yang, Ziming; Graham, David E.; Wullschleger, Stan D.; Gu, Baohua; Liang, Liyuan; Bargar, John; Janot, Noemie; Regier, Tom Z.

    2015-12-07

    Climate change is warming tundra ecosystems in the Arctic, resulting in the decomposition of previously-frozen soil organic matter (SOM) and release of carbon (C) to the atmosphere; however, the processes that control SOM decomposition and C emissions remain highly uncertain. In this study, we evaluate geochemical factors that influence anaerobic production of carbon dioxide (CO2) and methane (CH4) in the active layers of four ice-wedge polygons. Surface and soil pore waters were collected during the annual thaw season over a two-year period in an area containing waterlogged, low-centered polygons and well-drained, high-centered polygons. We report spatial and seasonal patterns of dissolved gases in relation to the geochemical properties of Fe and organic C as determined using spectroscopic and chromatographic techniques. Iron was present as Fe(II) in soil solution near the permafrost boundary but enriched as Fe(III) in the middle of the active layer, similar to dissolved aromatic-C and organic acids. Dissolved CH4 increased relative to dissolved CO2 with depth and varied with soil moisture in the middle of the active layer in patterns that were positively correlated with the proportion of dissolved Fe(III) in transitional and low-centered polygon soils but negatively correlated in the drier flat- and high-centered polygons. These results suggest that microbial-mediated Fe oxidation and reduction influence respiration/fermentation of SOM and production of substrates (e.g., low-molecular-weight organic acids) for methanogenesis. As a result, we infer that geochemical differences induced by water saturation dictate microbial products of SOM decomposition, and Fe geochemistry is an important factor regulating methanogenesis in anoxic tundra soils.

  15. Economics of induction linac drivers for radiation sources

    SciTech Connect (OSTI)

    Barletta, W.A.

    1987-06-15

    Recent developments in high reliability components for linear induction accelerators (LIA) make possible the use of LIAs as large-scale, economical sources of radio-frequency (rf) power for many applications. One particularly attractive example of interest to high energy physicists is a ''two-beam accelerator'' version of a linear e/sup +/-e/sup -/ collider at TeV energies in which the LIA is configured as a monolithic relativistic klystron operating at 10 to 12 GHz. Another example of keen interest to the fusion community is the use of the LIA to drive a free-electron laser operating at 200 to 500 GHz for use in heating fusion plasma via electron resonance cyclotron heating. This paper briefly describes several potential uses of LIA radiation sources. It discusses the physical basis for scaling our present experience with LIAs to the operating characteristics applicable to large-scale sources of rf power and synchrotron radiation. 14 refs., 6 figs., 1 tab.

  16. FFAG-BASED HIGH-INTENSITY PROTON DRIVERS.

    SciTech Connect (OSTI)

    RUGGIERO, A.G.

    2004-10-13

    This paper is the summary of a feasibility study of a Fixed-Field Alternating-Gradient (FFAG) Accelerator for Protons in the one-to-few GeV energy range, and average beam power of several MWatt. The example they have adopted here is a beam energy of 1 GeV and an average power of 10 MWatt, but of course the same design approach can be used with other beam parameters. The design principles, merits and limitations of the FFAG accelerators have been described previously. In particular, more advanced techniques to minimize magnet dimension and field strength have been recently proposed. The design makes use of a novel concept by which it is possible to cancel chromatic effects, thus making betatron tunes and functions independent of the particle momentum, with an Adjusted Field Profile. The example given here assumes a pulsed mode of operation at the repetition rate of 1.0 kHz.

  17. Analyzing Fuel Saving Opportunities through Driver Feedback Mechanisms

    Office of Energy Efficiency and Renewable Energy (EERE)

    2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation

  18. High Temperature, High Voltage Fully Integrated Gate Driver Circuit

    Broader source: Energy.gov [DOE]

    2009 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C.

  19. Drivers of Success in the Better Buildings Neighborhood Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Prepared For: U.S. Department of Energy Office of Energy Efficiency and Renewable Energy ... Medical University of Vienna, Vienna, Austria. http:www.meduniwien.ac.atuser...

  20. Overview of Driver Technologies for Nanosecond Tem Kickers (Conference...

    Office of Scientific and Technical Information (OSTI)

    Authors: Krasnykh, A. ; SLAC Publication Date: 2016-02-18 OSTI Identifier: 1238569 Report Number(s): SLAC-PUB-16481 DOE Contract Number: AC02-76SF00515 Resource Type: Conference ...

  1. Alternative Fuels Data Center: Techniques for Drivers to Conserve...

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Fuel is required to provide the energy necessary to overcome resistance from air and tire ... Devices and additives claiming to improve fuel economy and reduce pollution are usually ...

  2. B Decays Involving Light Mesons

    SciTech Connect (OSTI)

    Eschrich, Ivo Gough; /UC, Irvine

    2007-01-09

    Recent BABAR results for decays of B-mesons to combinations of non-charm mesons are presented. This includes B decays to two vector mesons, B {yields} {eta}{prime}({pi}, K, {rho}) modes, and a comprehensive Dalitz Plot analysis of B {yields} KKK decays.

  3. Appendix V Public Involvement Plan

    Office of Legacy Management (LM)

    ... Attachment 1: Overview of the Nevada Test Site ......Number Title Page Figure 1 - Nevada Test Site and Surrounding Areas......

  4. Classified Visits Involving Foreign Nationals

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-01-13

    The Order establishes a program to manage the Department-wide program to facilitate, document, and assure accountability when approving foreign national access to classified DOE programs and facilities. Cancels portions of Chapter VIII, of DOE O 470.1 that pertain to foreign nationals who visit DOE sitess and require access to classified information. Canceled by DOE O 470.4B.

  5. Who's Involved | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy case you missed it, last Thursday's White House Solar Champions of Change and Solar Summit shed a spotlight on all the amazing work that solar innovators around country are doing to speed deployment and make it faster, cheaper and easier to go solar! The progress made over the last three years toward the SunShot goals is something we are all excited about and in just four weeks, we look forward to welcoming the entire solar community to the SunShot Grand Challenge Summit

  6. Safety Success Through Employee Involvement

    Broader source: Energy.gov [DOE]

    Presenters: James Pollard, Monica Lewis, Michael Hendrix, Stacy Miller, Y-12 National Security Complex Track 2-2

  7. NEPA-Related Public Involvement

    Broader source: Energy.gov [DOE]

    The Loan Programs Office’s NEPA-related hearings, public meetings, and public notices (e.g. public scoping meeting, public hearing, notice of proposed floodplain or wetland action) are presented...

  8. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March 5, 2014 State of the Site (SOS) Meetings * HAB - all four meetings o Doesn't have to be manned o What HAB materials should be available?  HAB values paper o Have info available for the public (table idea) o Need to coordinate display board at each meeting * Have table/poster available for public to make suggestions on cleanup topics (next to display board) o Fact sheets of specific projects available o Briefing document of important website pages/links to important issues. * Suggest not

  9. Cyber Incidents Involving Control Systems

    SciTech Connect (OSTI)

    Robert J. Turk

    2005-10-01

    The Analysis Function of the US-CERT Control Systems Security Center (CSSC) at the Idaho National Laboratory (INL) has prepared this report to document cyber security incidents for use by the CSSC. The description and analysis of incidents reported herein support three CSSC tasks: establishing a business case; increasing security awareness and private and corporate participation related to enhanced cyber security of control systems; and providing informational material to support model development and prioritize activities for CSSC. The stated mission of CSSC is to reduce vulnerability of critical infrastructure to cyber attack on control systems. As stated in the Incident Management Tool Requirements (August 2005) ''Vulnerability reduction is promoted by risk analysis that tracks actual risk, emphasizes high risk, determines risk reduction as a function of countermeasures, tracks increase of risk due to external influence, and measures success of the vulnerability reduction program''. Process control and Supervisory Control and Data Acquisition (SCADA) systems, with their reliance on proprietary networks and hardware, have long been considered immune to the network attacks that have wreaked so much havoc on corporate information systems. New research indicates this confidence is misplaced--the move to open standards such as Ethernet, Transmission Control Protocol/Internet Protocol, and Web technologies is allowing hackers to take advantage of the control industry's unawareness. Much of the available information about cyber incidents represents a characterization as opposed to an analysis of events. The lack of good analyses reflects an overall weakness in reporting requirements as well as the fact that to date there have been very few serious cyber attacks on control systems. Most companies prefer not to share cyber attack incident data because of potential financial repercussions. Uniform reporting requirements will do much to make this information available to Department of Homeland Security (DHS) and others who require it. This report summarizes the rise in frequency of cyber attacks, describes the perpetrators, and identifies the means of attack. This type of analysis, when used in conjunction with vulnerability analyses, can be used to support a proactive approach to prevent cyber attacks. CSSC will use this document to evolve a standardized approach to incident reporting and analysis. This document will be updated as needed to record additional event analyses and insights regarding incident reporting. This report represents 120 cyber security incidents documented in a number of sources, including: the British Columbia Institute of Technology (BCIT) Industrial Security Incident Database, the 2003 CSI/FBI Computer Crime and Security Survey, the KEMA, Inc., Database, Lawrence Livermore National Laboratory, the Energy Incident Database, the INL Cyber Incident Database, and other open-source data. The National Memorial Institute for the Prevention of Terrorism (MIPT) database was also interrogated but, interestingly, failed to yield any cyber attack incidents. The results of this evaluation indicate that historical evidence provides insight into control system related incidents or failures; however, that the limited available information provides little support to future risk estimates. The documented case history shows that activity has increased significantly since 1988. The majority of incidents come from the Internet by way of opportunistic viruses, Trojans, and worms, but a surprisingly large number are directed acts of sabotage. A substantial number of confirmed, unconfirmed, and potential events that directly or potentially impact control systems worldwide are also identified. Twelve selected cyber incidents are presented at the end of this report as examples of the documented case studies (see Appendix B).

  10. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to update on Class III RCRA permit mods Hillary 2. All mods Class IIIII for RCRA Permit ... how they responded to 300 Area Susan wHillary 5. Ask for RAP to weigh in on March Board ...

  11. Public Involvment Plan - Rifle, Colorado

    Office of Legacy Management (LM)

    ... Atomic Energy Commission (AEC) records from 1947 to 1958 show that 761,000 tons of ore ... that included the upgrading facilities at Slick Rock, Colorado, and Green River, Utah. ...

  12. De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis

    SciTech Connect (OSTI)

    Cárdenas-Conejo, Yair; Carballo-Uicab, Víctor; Lieberman, Meric; Aguilar-Espinosa, Margarita; Comai, Luca; Rivera-Madrid, Renata

    2015-10-28

    Bixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L. An enzymatic pathway for bixin biosynthesis was inferred from homology of putative proteins encoded by differentially expressed seed cDNAs. Some activities were later validated in a heterologous system. Nevertheless, much of the pathway remains to be clarified. For example, it is essential to identify the methylerythritol phosphate (MEP) and carotenoid pathways genes. In order to investigate the MEP, carotenoid, and bixin pathways genes, total RNA from young leaves and two different developmental stages of seeds from B. orellana were used for the construction of indexed mRNA libraries, sequenced on the Illumina HiSeq 2500 platform and assembled de novo using Velvet, CLC Genomics Workbench and CAP3 software. A total of 52,549 contigs were obtained with average length of 1,924 bp. Two phylogenetic analyses of inferred proteins, in one case encoded by thirteen general, single-copy cDNAs, in the other from carotenoid and MEP cDNAs, indicated that B. orellana is closely related to sister Malvales species cacao and cotton. Using homology, we identified 7 and 14 core gene products from the MEP and carotenoid pathways, respectively. Surprisingly, previously defined bixin pathway cDNAs were not present in our transcriptome. Here we propose a new set of gene products involved in bixin pathway. In conclusion, the identification and qRT-PCR quantification of cDNAs involved in annatto production suggest a hypothetical model for bixin biosynthesis that involve coordinated activation of some MEP, carotenoid and bixin pathway genes. These findings provide a better understanding of the mechanisms regulating these pathways and will facilitate the genetic improvement of B. orellana.

  13. Optimized Volumetric Modulated Arc Therapy Versus 3D-CRT for Early Stage Mediastinal Hodgkin Lymphoma Without Axillary Involvement: A Comparison of Second Cancers and Heart Disease Risk

    SciTech Connect (OSTI)

    Filippi, Andrea Riccardo; Ragona, Riccardo; Piva, Cristina; Scafa, Davide; Fiandra, Christian; Fusella, Marco; Giglioli, Francesca Romana; Lohr, Frank; Ricardi, Umberto

    2015-05-01

    Purpose: The purpose of this study was to evaluate the risks of second cancers and cardiovascular diseases associated with an optimized volumetric modulated arc therapy (VMAT) planning solution in a selected cohort of stage I/II Hodgkin lymphoma (HL) patients treated with either involved-node or involved-site radiation therapy in comparison with 3-dimensional conformal radiation therapy (3D-CRT). Methods and Materials: Thirty-eight patients (13 males and 25 females) were included. Disease extent was mediastinum alone (n=8, 21.1%); mediastinum plus unilateral neck (n=19, 50%); mediastinum plus bilateral neck (n=11, 29.9%). Prescription dose was 30 Gy in 2-Gy fractions. Only 5 patients had mediastinal bulky disease at diagnosis (13.1%). Anteroposterior 3D-CRT was compared with a multiarc optimized VMAT solution. Lung, breast, and thyroid cancer risks were estimated by calculating a lifetime attributable risk (LAR), with a LAR ratio (LAR{sub VMAT}-to-LAR{sub 3D-CRT}) as a comparative measure. Cardiac toxicity risks were estimated by calculating absolute excess risk (AER). Results: The LAR ratio favored 3D-CRT for lung cancer induction risk in mediastinal alone (P=.004) and mediastinal plus unilateral neck (P=.02) presentations. LAR ratio for breast cancer was lower for VMAT in mediastinal plus bilateral neck presentations (P=.02), without differences for other sites. For thyroid cancer, no significant differences were observed, regardless of anatomical presentation. A significantly lower AER of cardiac (P=.038) and valvular diseases (P<.0001) was observed for VMAT regardless of disease extent. Conclusions: In a cohort of patients with favorable characteristics in terms of disease extent at diagnosis (large prevalence of nonbulky presentations without axillary involvement), optimized VMAT reduced heart disease risk with comparable risks of thyroid and breast cancer, with an increase in lung cancer induction probability. The results are however strongly influenced by

  14. Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos

    SciTech Connect (OSTI)

    Farhat, Amani; Buick, Julie K.; Williams, Andrew; Yauk, Carole L.; O'Brien, Jason M.; Crump, Doug; Williams, Kim L.; Chiu, Suzanne; Kennedy, Sean W.

    2014-03-01

    We previously demonstrated that in ovo exposure to the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP) decreased plasma thyroxine levels, reduced growth parameters, and decreased gallbladder size in chicken embryos. In the current study DNA microarrays were used to evaluate global mRNA expression in liver tissue of male chicken embryos that exhibited the above mentioned effects. Injected doses were dimethyl sulfoxide vehicle control, 7.6 or 45 ?g TDCPP/g egg. TDCPP caused significant changes in the expression of five genes at the low dose and 47 genes at the high dose (False Discovery Rate p ? 0.1, fold change ? 1.5). The gene expression analysis suggested a compromised immune function, a state of cholestatic liver/biliary fibrosis, and disrupted lipid and steroid metabolism. Circulating bile acid levels were elevated, which is an indication of liver dysfunction, and plasma cholesterol levels were reduced; however, hepatic bile acid and cholesterol levels were unaltered. Interactome analyses identified apolipoprotein E, hepatocyte nuclear factor 4 alpha, and peroxisome proliferator-activated receptor alpha as key regulatory molecules involved in the effects of TDCPP. Our results demonstrate a targeted effect of TDCPP toxicity on lipid metabolism, including cholesterol, that helps explain the aforementioned phenotypic effects, as chicken embryos are highly dependent on yolk lipids for growth and maintenance throughout development. Finally, our results are in concordance with the literature that describes TDCPP as a cancer-causing agent, since the majority of dysregulated genes were involved in cancer pathways. - Highlights: TDCPP dysregulates genes involved in immune function and lipid metabolism. A targeted effect of TDCPP toxicity on cholesterol metabolism is apparent. A state of cholestatic liver fibrosis is suggested by the expression profile. Elevated plasma bile acids suggest that TDCPP causes liver dysfunction.

  15. As you may kn&<' the~de&tment of &~er& (D&j 1s involved'in'a pronram

    Office of Legacy Management (LM)

    As you may kn&<' the~de&tment of &~er& (D&j 1s involved'in'a pronram '. to'chiiracterlze the radjologital cbndif~on of ,sites formerly used byythe . . . ., Manhattan Engineer Dlstrlct (NED) and/or Atomjc Energy Co$n~~lssiqq (AEC); in.. the development of 'nuclear energy.. As part..of this -programi' DOE is 1~ I+ preparing, ,a' series of. brJef~ summaries ,-of .the' history:. of' tho ,#D/AEC~ : : ..; 'i ..relatecl activities and 'Conditions at .thc. sneclfic. sites. The

  16. Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation

    SciTech Connect (OSTI)

    Fu, Na; Su, Dian; Cort, John R.; Chen, Baowei; Xiong, Yijia; Qian, Weijun; Konopka, Allan; Bigelow, Diana J.; Squier, Thomas C.

    2013-03-06

    Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic pathways in response to changing environmental conditions. To enable in vivo measurements of cellular redox changes linked to disulfide bond formation, we have synthesized a cell-permeable monosubstituted cyanine dye derivatized with arsenic (i.e., TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins. Alkylation of reactive thiols prior to displacement of the bound TRAP-Cy3 by ethanedithiol permits facile protein capture and mass spectrometric identification of proximal reduced dithiols to the exclusion of individual cysteines. Applying TRAP_Cy3 to evaluate cellular responses to increases in oxygen and light levels in the photosynthetic microbe Synechococcus sp. PCC 7002, we observe large decreases in the abundance of reduced dithiols in cellular proteins, which suggest redox-dependent mechanisms involving the oxidation of proximal disulfides. Under these same growth conditions that result in the oxidation of proximal thiols, there is a reduction in the abundance of post-translational oxidative modifications involving nitrotyrosine and methionine sulfoxide formation. These results suggest that the redox status of proximal cysteines respond to environmental conditions, acting to regulate metabolic flux and minimize the formation of reactive oxygen species to decrease oxidative protein damage.

  17. Kinetics and dynamics of oxidation reactions involving adsorbed CO species on bulk supported Pt and copper oxides. Final project report, January 1, 1991--December 31, 1993

    SciTech Connect (OSTI)

    Conner, Wm.C.; Harold, M.

    1995-02-01

    This research was an integrated experimental and modeling study of oxidation reactions involving CO as a key player - be it a reactant, adsorbed intermediate, and/or partial oxidation product - in the catalytic sequence and chemistry. The reaction systems of interest in the project include CO, formaldehyde, and methanol oxidation by O{sub 2}, and CO oxidation by NO, on both Pt and copper oxide catalysts. These reactions are of importance in automobile exhaust catalysis. There is a paucity of rate data in the literature for these important environmental control reactions. A complicating factor is the propensity of these reactions to exhibit complex steady state and dynamic behavior, including multiple rate controlling steps, steady state multiplicity, and oscillatory phenomena. Such phenomena are rooted in some of the central issues of catalysis, including adsorbate interactions, and catalyst structural instabilities, such as surface reconstruction and surface chemical changes by oxidation- reduction. The goal of this research is to better understand the catalytic chemistry and kinetics of oxidations reactions involving CO as an adsorbed intermediate. Successfully meeting this goal requires an integration of basic kinetic measurements, in situ catalyst surface monitoring, kinetic modeling, and nonlinear mathematical tools. While the kinetics experiments have standard microreactor design, the potential for multiple and periodic rate states demands detailed procedures to pinpoint the bifurcation (ignition, extinction, Hopf) points. Kinetic models are constructed from rational mechanistic sequences and sound surface chemistry.

  18. Microenergetic research involving a coupled experimental and computational approach to evaluate microstructural effects on detonation and combustion at sub-millimeter geometries.

    SciTech Connect (OSTI)

    Nogan, John; Palmer, Jeremy Andrew; Brundage, Aaron L.; Long, Gregory T.; Wroblewski, Brian D.; Tappan, Alexander Smith; Renlund, Anita Mariana; Kravitz, Stanley H.; Baer, Melvin R.

    2006-07-01

    A new approach to explosive sample preparation is described in which microelectronics-related processing techniques are utilized. Fused silica and alumina substrates were prepared utilizing laser machining. Films of PETN were deposited into channels within the substrates by physical vapor deposition. Four distinct explosive behaviors were observed with high-speed framing photography by driving the films with a donor explosive. Initiation at hot spots was directly observed, followed by either energy dissipation leading to failure, or growth to a detonation. Unsteady behavior in velocity and structure was observed as reactive waves failed due to decreasing channel width. Mesoscale simulations were performed to assist in experiment development and understanding. We have demonstrated the ability to pattern these films of explosives and preliminary mesoscale simulations of arrays of voids showed effects dependent on void size and that detonation would not develop with voids below a certain size. Future work involves experimentation on deposited films with regular patterned porosity to elucidate mesoscale explosive behavior.

  19. Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and γ-radiation sensitivity

    SciTech Connect (OSTI)

    Kim, In Gyu; Kim, Seo Yoen; Biomedical Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 ; Kim, Hyun A; Kim, Jeong Yul; Lee, Jae Ha; Choi, Soo Im; Department of Radiation Biotechnology and Applied Radioisotope, University of Science and Technology , 989-111 Daedeok-daero, Yuseong-gu, Daejeon 305-353 ; Han, Jeong Ran; Kim, Kug Chan; Cho, Eun Wie

    2014-01-03

    Highlights: •DKK1 was expressed differently among non-small-cell lung cancer cell lines. •DKK1 negatively regulated ROMO1 gene expression. •Disturbance of DKK1 level induced the imbalance of cellular ROS. •DKK1/ROMO1-induced ROS imbalance is involved in cell survival in NSCLC. -- Abstract: Dickkopf1 (DKK1), a secreted protein involved in embryonic development, is a potent inhibitor of the Wnt signaling pathway and has been postulated to be a tumor suppressor or tumor promoter depending on the tumor type. In this study, we showed that DKK1 was expressed differently among non-small-cell lung cancer cell lines. The DKK1 expression level was much higher in A549 cells than in H460 cells. We revealed that blockage of DKK1 expression by silencing RNA in A549 cells caused up-regulation of intracellular reactive oxygen species (ROS) modulator (ROMO1) protein, followed by partial cell death, cell growth inhibition, and loss of epithelial–mesenchymal transition property caused by ROS, and it also increased γ-radiation sensitivity. DKK1 overexpression in H460 significantly inhibited cell survival with the decrease of ROMO1 level, which induced the decrease of cellular ROS. Thereafter, exogenous N-acetylcysteine, an antioxidant, or hydrogen peroxide, a pro-oxidant, partially rescued cells from death and growth inhibition. In each cell line, both overexpression and blockage of DKK1 not only elevated p-RB activation, which led to cell growth arrest, but also inactivated AKT/NF-kB, which increased radiation sensitivity and inhibited cell growth. This study is the first to demonstrate that strict modulation of DKK1 expression in different cell types partially maintains cell survival via tight regulation of the ROS-producing ROMO1 and radiation resistance.

  20. PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway

    SciTech Connect (OSTI)

    Hinoi, Eiichi; Iezaki, Takashi; Fujita, Hiroyuki; Watanabe, Takumi; Odaka, Yoshiaki; Ozaki, Kakeru; Yoneda, Yukio

    2014-07-18

    Highlights: • Akt is preferentially phosphorylated in BAT and sWAT of aP2-GDF5 mice. • PI3K/Akt signaling is involved in GDF5-induced brown adipogenesis. • PI3K/Akt signaling regulates GDF5-induced Smad5 phosphorylation. - Abstract: We have previously demonstrated promotion by growth differentiation factor-5 (GDF5) of brown adipogenesis for systemic energy expenditure through a mechanism relevant to activating the bone morphological protein (BMP) receptor/mothers against decapentaplegic homolog (Smad)/peroxisome proliferator-activated receptor gamma co-activator 1α (PGC-1α) pathway. Here, we show the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in brown adipogenesis mediated by GDF5. Overexpression of GDF5 in cells expressing adipocyte protein-2 markedly accelerated the phosphorylation of Smad1/5/8 and Akt in white and brown adipose tissues. In brown adipose tissue from heterozygous GDF5{sup Rgsc451} mutant mice expressing a dominant-negative (DN) GDF5 under obesogenic conditions, the basal phosphorylation of Smad1/5/8 and Akt was significantly attenuated. Exposure to GDF5 not only promoted the phosphorylation of both Smad1/5/8 and Akt in cultured brown pre-adipocytes, but also up-regulated Pgc1a and uncoupling protein-1 expression in a manner sensitive to the PI3K/Akt inhibitor Ly294002 as well as retroviral infection with DN-Akt. GDF5 drastically promoted BMP-responsive luciferase reporter activity in a Ly294002-sensitive fashion. Both Ly294002 and DN-Akt markedly inhibited phosphorylation of Smad5 in the nuclei of brown pre-adipocytes. These results suggest that PI3K/Akt signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad pathway.

  1. The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males

    SciTech Connect (OSTI)

    Zucchi, Sara; Bluethgen, Nancy; Ieronimo, Andrea; Fent, Karl

    2011-01-15

    Benzophenone-4 (BP-4) is frequently used as UV-absorber in cosmetics and materials protection. Despite its frequent detection in the aquatic environment potential effects on aquatic life are unknown. In this study, we evaluate the effects of BP-4 in eleuthero-embryos and in the liver, testis and brain of adult male fish on the transcriptional level by focusing on target genes involved in hormonal pathways to provide a more complete toxicological profile of this important UV-absorber. Eleuthero-embryos and males of zebrafish were exposed up to 3 days after hatching and for 14 days, respectively, to BP-4 concentrations between 30 and 3000 {mu}g/L. In eleuthero-embryos transcripts of vtg1, vtg3, esr1, esr2b, hsd17ss3, cyp19b cyp19a, hhex and pax8 were induced at 3000 {mu}g/L BP-4, which points to a low estrogenic activity and interference with early thyroid development, respectively. In adult males BP-4 displayed multiple effects on gene expression in different tissues. In the liver vtg1, vtg3, esr1 and esr2b were down-regulated, while in the brain, vtg1, vtg3 and cyp19b transcripts were up-regulated. In conclusion, the transcription profile revealed that BP-4 interferes with the expression of genes involved in hormonal pathways and steroidogenesis. The effects of BP-4 differ in life stages and adult tissues and point to an estrogenic activity in eleuthero-embryos and adult brain, and an antiestrogenic activity in the liver. The results indicate that BP-4 interferes with the sex hormone system of fish, which is important for the risk assessment of this UV-absorber.

  2. Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis

    SciTech Connect (OSTI)

    Meng, Qiang; Chen, Xin-li; Wang, Chang-yuan; Liu, Qi; Sun, Hui-jun; Sun, Peng-yuan; Huo, Xiao-kui; Liu, Zhi-hao; Yao, Ji-hong; Liu, Ke-xin

    2015-03-15

    Intrahepatic cholestasis is a clinical syndrome with systemic and intrahepatic accumulation of excessive toxic bile acids that ultimately cause hepatobiliary injury. Appropriate regulation of bile acids in hepatocytes is critically important for protection against liver injury. In the present study, we characterized the protective effect of alisol B 23-acetate (AB23A), a natural triterpenoid, on alpha-naphthylisothiocyanate (ANIT)-induced liver injury and intrahepatic cholestasis in mice and further elucidated the mechanisms in vivo and in vitro. AB23A treatment dose-dependently protected against liver injury induced by ANIT through reducing hepatic uptake and increasing efflux of bile acid via down-regulation of hepatic uptake transporters (Ntcp) and up-regulation of efflux transporter (Bsep, Mrp2 and Mdr2) expression. Furthermore, AB23A reduced bile acid synthesis through repressing Cyp7a1 and Cyp8b1, increased bile acid conjugation through inducing Bal, Baat and bile acid metabolism through an induction in gene expression of Sult2a1. We further demonstrate the involvement of farnesoid X receptor (FXR) in the hepatoprotective effect of AB23A. The changes in transporters and enzymes, as well as ameliorative liver histology in AB23A-treated mice were abrogated by FXR antagonist guggulsterone in vivo. In vitro evidences also directly demonstrated the effect of AB23A on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells. In conclusion, AB23A produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. - Highlights: • AB23A has at least three roles in protection against ANIT-induced liver injury. • AB23A decreases Ntcp, and increases Bsep, Mrp2 and Mdr2 expression. • AB23A represses Cyp7a1 and Cyp8b1 through inducing Shp and Fgf15 expression. • AB23A increases bile acid metabolism through inducing Sult2a1 expression. • FXR activation is involved

  3. Low-Dose Involved-Field Radiation in the Treatment of Non-Hodgkin Lymphoma: Predictors of Response and Treatment Failure

    SciTech Connect (OSTI)

    Russo, Andrea L.; Chen, Yu-Hui; Martin, Neil E.; Vinjamoori, Anant; Luthy, Sarah K.; Freedman, Arnold; Michaelson, Evan M.; Silver, Barbara; Mauch, Peter M.; Ng, Andrea K.

    2013-05-01

    Purpose: To investigate clinical and pathologic factors significant in predicting local response and time to further treatment after low-dose involved-field radiation therapy (LD-IFRT) for non-Hodgkin lymphoma (NHL). Methods and Materials: Records of NHL patients treated at a single institution between April 2004 and September 2011 were retrospectively reviewed. Low-dose involved-field radiation therapy was given as 4 Gy in 2 fractions over 2 consecutive days. Treatment response and disease control were determined by radiographic studies and/or physical examination. A generalized estimating equation model was used to assess the effect of tumor and patient characteristics on disease response. A Cox proportional hazards regression model was used to assess time to further treatment. Results: We treated a total of 187 sites in 127 patients with LD-IFRT. Histologies included 66% follicular, 9% chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma, 10% marginal zone, 6% mantle cell lymphoma (MCL), and 8% other. Median follow-up time was 23.4 months (range, 0.03-92.2 months). The complete response, partial response, and overall response rates were 57%, 25%, and 82%, respectively. A CLL histology was associated with a lower response rate (odds ratio 0.2, 95% confidence interval 0.1-0.5, P=.02). Tumor size, site, age at diagnosis, and prior systemic therapy were not associated with response. The median time to first recurrence was 13.6 months. Those with CLL and age ?50 years at diagnosis had a shorter time to further treatment for local failures (hazard ratio [HR] 3.63, P=.01 and HR 5.50, P=.02, respectively). Those with CLL and MCL had a shorter time to further treatment for distant failures (HR 11.1 and 16.3, respectively, P<.0001). Conclusions: High local response rates were achieved with LD-IFRT across most histologies. Chronic lymphocytic leukemia and MCL histologies and age ?50 years at diagnosis had a shorter time to further treatment after LD-IFRT.

  4. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

    SciTech Connect (OSTI)

    Hong, Wei; College of Basic Medicine, Tianjin Medical University, 300070 Tianjin ; Li, Jinru; Wang, Bo; Chen, Linfeng; Niu, Wenyan; Yao, Zhi; Baniahmad, Aria

    2011-12-02

    Highlights: Black-Right-Pointing-Pointer Corepressor Alien interacts with histone methyltransferase ESET in vivo. Black-Right-Pointing-Pointer Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TR{beta}1. Black-Right-Pointing-Pointer ESET-mediated H3K9 methylation is required for liganded TR{beta}1-repressed transcription. Black-Right-Pointing-Pointer ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by which Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TR{beta}1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TR{beta}1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TR{beta}1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TR{beta}1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.

  5. Thermal and combined thermal and radiolytic reactions involving nitrous oxide, hydrogen, nitrogen, and ammonia in contact with tank 241-SY-101 simulated waste

    SciTech Connect (OSTI)

    Bryan, S.A.; Pederson, L.R.

    1996-02-01

    Work described in this report was conducted at Pacific Northwest National Laboratory (PNNL) for the Flammable Gas Safety Project, the purpose of which is to develop information needed to support Westinghouse Hanford Company (WHC) in their efforts to ensure the safe interim storage of wastes at the Hanford Site. Described in this report are the results of tests to evaluate the rates of thermal and combined thermal and radiolytic reactions involving flammable gases in the presence of Tank 241-SY-101 simulated waste. Flammable gases generated by the radiolysis of water and by the thermal and radiolytic decomposition of organic waste constituents may themselves participate in further reactions. Examples include the decomposition of nitrous oxide to yield nitrogen and oxygen, the reaction of nitrous oxide and hydrogen to produce nitrogen and water, and the reaction of nitrogen and hydrogen to produce ammonia. The composition of the gases trapped in bubbles in the wastes might therefore change continuously as a function of the time that the gas bubbles are retained.

  6. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor ?E is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by ?E in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition ?E regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmoreSalmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by ?E in at least one of the three conditions. An important finding is that ?E up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, ?E is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between ?E and SPI-2 genes, combined with the global regulatory effect of ?E, may account for the lethality of rpoE-deficient Salmonella in murine infection.less

  7. Involvement of aldolase A in X-ray resistance of human HeLa and UV{sup r}-1 cells

    SciTech Connect (OSTI)

    Lu, Jun; Suzuki, Toshikazu Satoh, Mamoru; Chen, Shiping; Tomonaga, Takeshi; Nomura, Fumio; Suzuki, Nobuo

    2008-05-09

    To find novel proteins involved in radio-resistance of human cells, we searched for nuclear proteins, whose expression levels alter after X-ray irradiation in HeLa cells, using agarose fluorescent two-dimensional differential gel electrophoresis following mass spectrometry. We identified 6 proteins, whose levels were increased in nuclei 24 h after irradiation at 5 Gy, including aldolase A. Nuclear aldolase A levels increased twofold after the irradiation, however, total aldolase A levels did not change. When the expression of aldolase A was suppressed by its specific siRNA, sensitization of the suppressed cells to X-ray-induced cell death was observed. In addition, UV{sup r}-1 cells with higher aldolase A expression exhibited lower sensitivity to X-ray-induced cell death than the parental RSa cells with lower aldolase A expression. These results suggest that aldolase A may play a role in the radio-response of human cells, probably in nuclei, in addition to its glycolytic role in the cytosol.

  8. New Rydberg-Rydberg transitions of the ArH and ArD molecules: Bands involving s, p and d electronic states

    SciTech Connect (OSTI)

    Darbrowski, I.; Tokaryk, D.; Watson, J.K.G.

    1995-12-31

    8The previous analyses of the spectra of ArH and ArD are extended to other transitions between s, p and d complexes, using a case (d) Hamiltonian in which the rotational and centrifugal energies are expressed in powers of R{sup 2}. While l is not a perfect quantum number, it provides convenient labels for the states. The present analysis of bands involving the lowest bound state (5s) is restricted to ArD because the corresponding state of ArH is strongly predissociated. The bands 5p {r_arrow} 5s and 6p {r_arrow} 5s have been observed, but analysis of the former is hampered by interference by D{sub 3} emission. These bands show that the small {sigma} - {pi} separation found in the 4p complex is accidental. For example, 6p{sigma} - 6p{pi} is 69.9 cm{sup -1} (from the R = 0 Hamiltonian), whereas the corresponding separation in 4p is 2.0 cm{sup -1}. Observation of the 3d{delta} {r_arrow} 4p band completes the 3d complex, whose wide splitting ({sigma}, {pi} and {delta} components at 16311, 13016, and 14637 m{sup -1} relative to 5s in ArD) corresponds to an almost pure fourth-rank tensor pattern. The bands 6s {r_arrow} 4p and 8s {r_arrow} 4p have also been analysed.

  9. Nanowires, Capacitors, and Other Novel Outer-Surface Components Involved in Electron Transfer to Fe(III) Oxides in Geobacter Species

    SciTech Connect (OSTI)

    Lovley, Derek, R.

    2008-12-22

    The overall goal of this project was to better understand the mechanisms by which Geobacter species transfer electrons outside the cell onto Fe(III) oxides. The rationale for this study was that Geobacter species are often the predominant microorganisms involved in in situ uranium bioremediation and the growth and activity of the Geobacter species during bioremediation is primarily supported by electron transfer to Fe(III) oxides. These studies greatly expanded the understanding of electron transfer to Fe(III). Novel concepts developed included the potential role of microbial nanowires for long range electron transfer in Geobacter species and the importance of extracytoplasmic cytochromes functioning as capacitors to permit continued electron transfer during the hunt for Fe(III) oxide. Furthermore, these studies provided target sequences that were then used in other studies to tract the activity of Geobacter species in the subsurface through monitoring the abundance of gene transcripts of the target genes. A brief summary of the major accomplishments of the project is provided.

  10. GABA/sub B/ receptor activation inhibits Ca/sup 2 +/-activated potassium channels in synaptosomes: involvement of G-proteins

    SciTech Connect (OSTI)

    Ticku, M.K.; Delgado, A.

    1989-01-01

    /sup 86/Rb-efflux assay from preloaded synaptosomes of rat cerebral cortex was developed to study the effect of GABA/sub B/ receptor agonist baclofen on Ca/sup 2 +/-activated K/sup +/-channels. Depolarization of /sup 86/Rb-loaded synaptosomes in physiological buffer increased Ca/sup 2 +/-activated /sup 86/Rb-efflux by 400%. The /sup 86/Rb-efflux was blocked by quinine sulfate, tetraethylammonium, and La/sup 3 +/ indicating the involvement of Ca/sup 2 +/-activated K/sup +/-channels. (-)Baclofen inhibited Ca/sup 2 +/-activated /sup 86/Rb-efflux in a stereospecific manner. The inhibitory effect of (-)baclofen was mediated by GABA/sub B/ receptor activation, since it was blocked by GABA/sub B/ antagonist phaclofen, but not by bicuculline. Further, pertussis toxin also blocked the ability of baclofen or depolarizing action to affect Ca/sup 2 +/-activated K/sup +/-channels. These results suggest that baclofen inhibits Ca/sup 2 +/-activated K/sup +/-channels in synaptosomes and these channels are regulated by G-proteins. This assay may provide an ideal in vitro model to study GABA/sub B/ receptor pharmacology.

  11. t(8; 14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region

    SciTech Connect (OSTI)

    Haluska, F.G.; Tsujimoto, Y.; Croce, C.M.

    1987-10-01

    Recent molecular analyses of Burkitt lymphomas carrying the t(8;14) chromosome translocation have indicated that a dichotomy exists regarding the molecular mechanisms by which the translocations occur. Most sporadic Burkitt tumors carry translocations that apparently arise due to mistakes in the immunoglobulin isotype-switching process. In contrast, there is evidence that the translocations of most endemic Burkitt lymphomas occur as a consequence of aberrant V-D-J recombination of variable, diversity, and joining gene segments, catalyzed by the recombinase enzymes. This phenomenon was first noted in follicular lymphomas and chronic lymphocytic leukemias of the B-cell lineage and has been described in T-cell malignancies as well. In each of these cases, analysis of the nucleotide sequence at chromosome breakpoints demonstrated the involvement of immunoglobulin heavy chain J/sub H/ or T-cell-receptor ..cap alpha..-chain J..cap alpha.. gene segments in the translocation. The authors now have cloned and sequenced both the 8q- and 14q+ translocation breakpoints deriving from the t(8;14) translocation of the endemic Burkitt lymphoma line Daudi. The data show that the translocation resulted from a reciprocal exchange between the D/sub H/ region on chromosome 14 and sequences far 5' of the MYC protooncogene on chromosome 8. Features of the nucleotide sequences surrounding the breakpoint further implicate the V-D-J joining machinery in the genesis of chromosome translocation in endemic Burkitt lymphomas and, more generally, in other lymphoid malignancies as well.

  12. Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma

    SciTech Connect (OSTI)

    Maroni, Paola; Matteucci, Emanuela; Drago, Lorenzo; Banfi, Giuseppe; Bendinelli, Paola; Desiderio, Maria Alfonsina

    2015-01-15

    The present study deals with the molecular mechanisms involved in the regulation of E-cadherin expression under hypoxia, because the adjustment of the amount of E-cadherin due to physical stimuli of the microenvironment might influence the colonization of metastasis to skeleton. We analyzed the effect of 1% oxygen tension, that is similar to that encountered in the bone marrow by metastatic cells spreading from breast carcinoma. The purpose was to evaluate the hypoxia-orchestrated control of E-cadherin transactivation via hypoxia inducible factor-1 (HIF-1) and peroxisome proliferator activated receptor-γ (PPARγ), and the involvement of Hippo pathway members, as regulators of transcription factors. To give a translational significance to the study, we took into consideration human pair-matched ductal breast carcinoma and bone metastasis: E-cadherin and Wwox were expressed in bone metastasis but not in breast carcinoma, while HIF-1α and TAZ seemed localized principally in nuclei of metastasis and were found in all cell compartments of breast carcinoma. A close examination of the regulatory mechanisms underlying E-cadherin expression in bone metastasis was done in 1833 clone derived from MDA-MB231 cells. Hypoxia induced E-cadherin only in 1833 clone, but not in parental cells, through HIF-1 and PPARγ activities, while Wwox decreased. Since Wwox was highly expressed in bone metastasis, the effect of ectopic Wwox was evaluated, and we showed E-cadherin transactivation and enhanced invasiveness in WWOX transfected 1833 cells. Also, hypoxia was additive with ectopic Wwox remarkably enhancing HIF-1α nuclear shuttle and accumulation due to the lengthening of the half-life of HIF-1α protein; under this experimental condition HIF-1α appeared as a slower migrated band compared with control, in agreement with the phosphorylation state. The in vitro data strongly supported the almost exclusive presence of HIF-1α in nuclei of human-bone metastasis. Thus, we identified

  13. Metaproteomics Identifies the Protein Machinery Involved in Metal and Radionuclide Reduction in Subsurface Microbiomes and Elucidates Mechanisms and U(VI) Reduction Immobilization

    SciTech Connect (OSTI)

    Pfiffner, Susan M.; Löffler, Frank; Ritalahti, Kirsti; Sayler, Gary; Layton, Alice; Hettich, Robert

    2015-08-31

    The overall goal for this funded project was to develop and exploit environmental metaproteomics tools to identify biomarkers for monitoring microbial activity affecting U speciation at U-contaminated sites, correlate metaproteomics profiles with geochemical parameters and U(VI) reduction activity (or lack thereof), elucidate mechanisms contributing to U(VI) reduction, and provide remediation project managers with additional information to make science-based site management decisions for achieving cleanup goals more efficiently. Although significant progress has been made in elucidating the microbiology contribution to metal and radionuclide reduction, the cellular components, pathway(s), and mechanisms involved in U trans-formation remain poorly understood. Recent advances in (meta)proteomics technology enable detailed studies of complex samples, including environmental samples, which differ between sites and even show considerable variability within the same site (e.g., the Oak Ridge IFRC site). Additionally, site-specific geochemical conditions affect microbial activity and function, suggesting generalized assessment and interpretations may not suffice. This research effort integrated current understanding of the microbiology and biochemistry of U(VI) reduction and capitalize on advances in proteomics technology made over the past few years. Field-related analyses used Oak Ridge IFRC field ground water samples from locations where slow-release substrate biostimulation has been implemented to accelerate in situ U(VI) reduction rates. Our overarching hypothesis was that the metabolic signature in environmental samples, as deciphered by the metaproteome measurements, would show a relationship with U(VI) reduction activity. Since metaproteomic and metagenomic characterizations were computationally challenging and time-consuming, we used a tiered approach that combines database mining, controlled laboratory studies, U(VI) reduction activity measurements, phylogenetic

  14. Impact of Cranial Irradiation Added to Intrathecal Conditioning in Hematopoietic Cell Transplantation in Adult Acute Myeloid Leukemia With Central Nervous System Involvement

    SciTech Connect (OSTI)

    Mayadev, Jyoti S.; Douglas, James G.; Storer, Barry E.; Appelbaum, Frederick R.; Storb, Rainer

    2011-05-01

    Purpose: Neither the prognostic importance nor the appropriate management of central nervous system (CNS) involvement is known for patients with acute myeloid leukemia (AML) undergoing hematopoietic cell transplantation (HCT). We examined the impact of a CNS irradiation boost to standard intrathecal chemotherapy (ITC). Methods and Materials: From 1995 to 2005, a total of 648 adult AML patients received a myeloablative HCT: 577 patients were CNS negative (CNS-), and 71 were CNS positive (CNS+). Of the 71 CNS+ patients, 52 received intrathecal chemotherapy alone (CNS+ITC), and 19 received ITC plus an irradiation boost (CNS+RT). Results: The CNS-, CNS+ITC, and CNS+RT patients had 1- and 5-year relapse-free survivals (RFS) of 43% and 35%, 15% and 6%, and 37% and 32%, respectively. CNS+ITC patients had a statistically significant worse RFS compared with CNS- patients (hazard ratio [HR], 2.65; 95% confidence interval [CI], 2.0-3.6; p < 0.0001). CNS+RT patients had improved relapse free survival over that of CNS+ITC patients (HR, 0.45; 95% CI, 0.2-0.8; p = 0.01). The 1- and 5-year overall survivals (OS) of patients with CNS-, CNS+ITC, and CNS+RT, were 50% and 38%, 21% and 6%, and 53% and 42%, respectively. The survival of CNS+RT were significantly better than CNS+ITC patients (p = 0.004). After adjusting for known risk factors, CNS+RT patients had a trend toward lower relapse rates and reduced nonrelapse mortality. Conclusions: CNS+ AML is associated with a poor prognosis. The role of a cranial irradiation boost to intrathecal chemotherapy appears to mitigate the risk of CNS disease, and needs to be further investigated to define optimal treatment strategies.

  15. Murine natural resistance to Trypanosoma lewisi involves complement component C3 and radiation-resistant, silica dust-sensitive effector cells

    SciTech Connect (OSTI)

    Albright, J.W.; Albright, J.F.

    1985-01-01

    The phenomenon of natural (innate) resistance is exemplified by the solid resistance of mice to infection with the rat-specific Trypanosoma lewisi. We provide more information about the mechanism of resistance in this model system. Resistance was not diminished in aged mice or reduced by ionizing radiation or splenectomy. There was no difference in resistance of C5-deficient mice (B10.D2/oSn and AKR) compared with their normocomplementemic counterparts (B10.D2/nSn and C57BL/6). Treatment of mice with cobra venom factor resulted in greatly prolonged survival of T. lewisi in mice. Combined treatment of mice with cobra venom factor and silica dust resulted in not only prolonged survival but also considerable intravascular growth of the parasite and resultant death of the mice. T. lewisi cells from irradiated donor rats, or after surface coat removal with trypsin, were eliminated by inoculated mice more efficiently than were parasites acquired from normal rats. Incubation of trypanosomes obtained from irradiated rats in normal rat serum restored their resistance to rapid elimination. From the results of these studies and other recent investigations, we have concluded that murine resistance to T. lewisi involves activation and binding of C3b by uncoated trypanosomes and concomitant participation of radiation-resistant, silica dust-sensitive effector cells (probably macrophages and neutrophils), and rat plasma proteins, integrated into the trypanosome surface coat, stabilize the coat, make it less susceptible to removal when the trypanosome is present in the mouse bloodstream, and thus delay exposure of underlying molecules (receptors) that activate murine C3.

  16. Epithelialmesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells

    SciTech Connect (OSTI)

    Ding, Song-Ze; Yang, Yu-Xiu; Li, Xiu-Ling; Michelli-Rivera, Audrey; Han, Shuang-Yin; Wang, Lei; Pratheeshkumar, Poyil; Wang, Xin; Lu, Jian; Yin, Yuan-Qin; Budhraja, Amit; Hitron, Andrew J.

    2013-05-15

    Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Exposure to Cr(VI) induces DNA damage, cell morphological change and malignant transformation in human lung epithelial cells. Despite extensive studies, the molecular mechanisms remain elusive, it is also not known if Cr(VI)-induced transformation might accompany with invasive properties to facilitate metastasis. We aimed to study Cr(VI)-induced epithelialmesenchymal transition (EMT) and invasion during oncogenic transformation in lung epithelial cells. The results showed that Cr(VI) at low doses represses E-cadherin mRNA and protein expression, enhances mesenchymal marker vimentin expression and transforms the epithelial cell into fibroblastoid morphology. Cr(VI) also increases cell invasion and promotes colony formation. Further studies indicated that Cr(VI) uses multiple mechanisms to repress E-cadherin expression, including activation of E-cadherin repressors such as Slug, ZEB1, KLF8 and enhancement the binding of HDAC1 in E-cadherin gene promoter, but DNA methylation is not responsible for the loss of E-cadherin. Catalase reduces Cr(VI)-induced E-cadherin and vimentin protein expression, attenuates cell invasion in matrigel and colony formation on soft agar. These results demonstrate that exposure to a common human carcinogen, Cr(VI), induces EMT and invasion during oncogenic transformation in lung epithelial cells and implicate in cancer metastasis and prevention. - Graphical abstract: Epithelialmesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanisms in lung epithelial cells. - Highlights: We study if Cr(VI) might induce EMT and invasion in epithelial cells. Cr(VI) induces EMT by altering E-cadherin and vimentin expression. It also increases cell invasion and promotes oncogenic transformation. Catalase reduces Cr(VI)-induced EMT, invasion and

  17. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor σE is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by σE in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition σE regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmore » Salmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by σE in at least one of the three conditions. An important finding is that σE up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, σE is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between σE and SPI-2 genes, combined with the global regulatory effect of σE, may account for the lethality of rpoE-deficient Salmonella in murine infection.« less

  18. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    SciTech Connect (OSTI)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; Cambronne, Eric; Adkins, Joshua N.

    2015-02-10

    The extracytoplasmic functioning sigma factor σE is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by σE in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition σE regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved in Salmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by σE in at least one of the three conditions. An important finding is that σE up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, σE is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between σE and SPI-2 genes, combined with the global regulatory effect of σE, may account for the lethality of rpoE-deficient Salmonella in murine infection.

  19. Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB{sub 1} receptors and apoptotic cell death

    SciTech Connect (OSTI)

    Tomiyama, Ken-ichi; Funada, Masahiko

    2014-01-01

    The abuse of herbal products containing synthetic cannabinoids has become an issue of public concern. The purpose of this paper was to evaluate the acute cytotoxicity of synthetic cannabinoids on mouse brain neuronal cells. Cytotoxicity induced by synthetic cannabinoid (CP-55,940, CP-47,497, CP-47,497-C8, HU-210, JWH-018, JWH-210, AM-2201, and MAM-2201) was examined using forebrain neuronal cultures. These synthetic cannabinoids induced cytotoxicity in the forebrain cultures in a concentration-dependent manner. The cytotoxicity was suppressed by preincubation with the selective CB{sub 1} receptor antagonist AM251, but not with the selective CB{sub 2} receptor antagonist AM630. Furthermore, annexin-V-positive cells were found among the treated forebrain cells. Synthetic cannabinoid treatment induced the activation of caspase-3, and preincubation with a caspase-3 inhibitor significantly suppressed the cytotoxicity. These synthetic cannabinoids induced apoptosis through a caspase-3-dependent mechanism in the forebrain cultures. Our results indicate that the cytotoxicity of synthetic cannabinoids towards primary neuronal cells is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and further suggest that caspase cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. In conclusion, excessive synthetic cannabinoid abuse may present a serious acute health concern due to neuronal damage or deficits in the brain. - Highlights: Synthetic cannabinoids (classical cannabinoids, non-classical cannabinoids, and aminoalkylindole derivatives) induce cytotoxicity in mouse forebrain cultures. Synthetic cannabinoid-induced cytotoxicity towards forebrain cultures is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and involves caspase-dependent apoptosis. A high concentration of synthetic cannabinoids may be toxic to neuronal cells that express CB{sub 1} receptors.

  20. Additional Survival Benefit of Involved-Lesion Radiation Therapy After R-CHOP Chemotherapy in Limited Stage Diffuse Large B-Cell Lymphoma

    SciTech Connect (OSTI)

    Kwon, Jeanny; Kim, Il Han; Kim, Byoung Hyuck; Kim, Tae Min; Heo, Dae Seog

    2015-05-01

    Purpose: The purpose of this study was to evaluate the role of involved-lesion radiation therapy (ILRT) after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy in limited stage diffuse large B-cell lymphoma (DLBCL) by comparing outcomes of R-CHOP therapy alone with R-CHOP followed by ILRT. Methods and Materials: We identified 198 patients treated with R-CHOP (median, 6 cycles) for pathologically confirmed DLBCL of limited stage from July 2004 to December 2012. Clinical characteristics of these patients were 33% with stage I and 66.7% with stage II; 79.8% were in the low or low-intermediate risk group; 13.6% had B symptoms; 29.8% had bulky tumors (≥7 cm); and 75.3% underwent ≥6 cycles of R-CHOP therapy. RT was given to 43 patients (21.7%) using ILRT technique, which included the prechemotherapy tumor volume with a median margin of 2 cm (median RT dose: 36 Gy). Results: After a median follow-up of 40 months, 3-year progression-free survival (PFS) and overall survival (OS) were 85.8% and 88.9%, respectively. Multivariate analysis showed ≥6 cycles of R-CHOP (PFS, P=.004; OS, P=.004) and ILRT (PFS, P=.021; OS, P=.014) were favorable prognosticators of PFS and OS. A bulky tumor (P=.027) and response to R-CHOP (P=.012) were also found to be independent factors of OS. In subgroup analysis, the effect of ILRT was prominent in patients with a bulky tumor (PFS, P=.014; OS, P=.030) or an elevated level of serum lactate dehydrogenase (LDH; PFS, P=.004; OS, P=.012). Conclusions: Our results suggest that ILRT after R-CHOP therapy improves PFS and OS in patients with limited stage DLBCL, especially in those with bulky disease or an elevated serum LDH level.

  1. SU-E-T-587: Monte Carlo Versus Ray-Tracing for Treatment Planning Involving CNS Tumors On the MultiPlan System for CyberKnife Radiosurgery

    SciTech Connect (OSTI)

    Forbang, R Teboh

    2014-06-01

    Purpose: MultiPlan, the treatment planning system for the CyberKnife Robotic Radiosurgery system offers two approaches to dose computation, namely Ray-Tracing (RT), the default technique and Monte Carlo (MC), an option. RT is deterministic, however it accounts for primary heterogeneity only. MC on the other hand has an uncertainty associated with the calculation results. The advantage is that in addition, it accounts for heterogeneity effects on the scattered dose. Not all sites will benefit from MC. The goal of this work was to focus on central nervous system (CNS) tumors and compare dosimetrically, treatment plans computed with RT versus MC. Methods: Treatment plans were computed using both RT and MC for sites covering (a) the brain (b) C-spine (c) upper T-spine (d) lower T-spine (e) L-spine and (f) sacrum. RT was first used to compute clinically valid treatment plans. Then the same treatment parameters, monitor units, beam weights, etc., were used in the MC algorithm to compute the dose distribution. The plans were then compared for tumor coverage to illustrate the difference if any. All MC calculations were performed at a 1% uncertainty. Results: Using the RT technique, the tumor coverage for the brain, C-spine (C3–C7), upper T-spine (T4–T6), lower T-spine (T10), Lspine (L2) and sacrum were 96.8%, 93.1%, 97.2%, 87.3%, 91.1%, and 95.3%. The corresponding tumor coverage based on the MC approach was 98.2%, 95.3%, 87.55%, 88.2%, 92.5%, and 95.3%. It should be noted that the acceptable planning target coverage for our clinical practice is >95%. The coverage can be compromised for spine tumors to spare normal tissues such as the spinal cord. Conclusion: For treatment planning involving the CNS, RT and MC appear to be similar for most sites but for the T-spine area where most of the beams traverse lung tissue. In this case, MC is highly recommended.

  2. Direct Involvement of ombB, omaB and omcB Genes in Extracellular Reduction of Fe(III) by Geobacter sulfurreducens PCA

    SciTech Connect (OSTI)

    Liu, Yimo; Fredrickson, Jim K.; Zachara, John M.; Shi, Liang

    2015-10-01

    The tandem gene clusters orfR-ombB-omaB-omcB and orfS-ombC-omaC-omcC of the metal-reducing bacterium Geobacter sulfurreducens PCA are responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III)-citrate and ferrihydrite [a poorly crystalline Fe(III) oxide]. Each gene cluster encodes a putative transcriptional factor (OrfR/OrfS), a porin-like outer-membrane protein (OmbB/OmbC), a periplasmic c-type cytochrome (c-Cyt, OmaB/OmaC) and an outer-membrane c-Cyt (OmcB/OmcC). The individual roles of OmbB, OmaB and OmcB in extracellular reduction of Fe(III), however, have remained either uninvestigated or controversial. Here, we showed that replacements of ombB, omaB, omcB and ombB-omaB with an antibiotic gene in the presence of ombC-omaC-omcC had no impact on reduction of Fe(III)-citrate by G. sulfurreducens PCA. Disruption of ombB, omaB, omcB and ombB-omaB in the absence of ombC-omaC-omcC, however, severely impaired the bacterial ability to reduce Fe(III)-citrate as well as ferrihydrite. These results unequivocally demonstrate an overlapping role of ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction by G. sulfurreducens PCA. Involvement of both ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction reflects the importance of these trans-outer membrane protein complexes in the physiology of this bacterium. Moreover, the kinetics of Fe(III)-citrate and ferrihydrite reduction by these mutants in the absence of ombC-omaC-omcC were nearly identical, which clearly show that OmbB, OmaB and OmcB contribute equally to extracellular Fe(III) reduction. Finally, orfS was found to have a negative impact on the extracellular reduction of Fe(III)-citrate and ferrihydrite in G. sulfurreducens PCA probably by serving as a transcriptional repressor.

  3. Direct involvement of ombB, omaB, and omcB genes in extracellular reduction of Fe(III) by Geobacter sulfurreducens PCA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Liu, Yimo; Fredrickson, Jim K.; Zachara, John M.; Shi, Liang

    2015-10-01

    The tandem gene clusters orfR-ombB-omaB-omcB and orfS-ombC-omaC-omcC of the metal-reducing bacterium Geobacter sulfurreducens PCA are responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III)-citrate and ferrihydrite [a poorly crystalline Fe(III) oxide]. Each gene cluster encodes a putative transcriptional factor (OrfR/OrfS), a porin-like outer-membrane protein (OmbB/OmbC), a periplasmic c-type cytochrome (c-Cyt, OmaB/OmaC) and an outer-membrane c-Cyt (OmcB/OmcC). The individual roles of OmbB, OmaB and OmcB in extracellular reduction of Fe(III), however, have remained either uninvestigated or controversial. Here, we showed that replacements of ombB, omaB, omcB and ombB-omaB with an antibiotic gene in the presence of ombC-omaC-omcC had nomore » impact on reduction of Fe(III)-citrate by G. sulfurreducens PCA. Disruption of ombB, omaB, omcB and ombB-omaB in the absence of ombC-omaC-omcC, however, severely impaired the bacterial ability to reduce Fe(III)-citrate as well as ferrihydrite. These results unequivocally demonstrate an overlapping role of ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction by G. sulfurreducens PCA. Involvement of both ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction reflects the importance of these trans-outer membrane protein complexes in the physiology of this bacterium. Moreover, the kinetics of Fe(III)-citrate and ferrihydrite reduction by these mutants in the absence of ombC-omaC-omcC were nearly identical, which clearly show that OmbB, OmaB and OmcB contribute equally to extracellular Fe(III) reduction. Finally, orfS was found to have a negative impact on the extracellular reduction of Fe(III)-citrate and ferrihydrite in G. sulfurreducens PCA probably by serving as a transcriptional repressor.« less

  4. Direct involvement of ombB, omaB, and omcB genes in extracellular reduction of Fe(III) by Geobacter sulfurreducens PCA

    SciTech Connect (OSTI)

    Liu, Yimo; Fredrickson, Jim K.; Zachara, John M.; Shi, Liang

    2015-10-01

    The tandem gene clusters orfR-ombB-omaB-omcB and orfS-ombC-omaC-omcC of the metal-reducing bacterium Geobacter sulfurreducens PCA are responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III)-citrate and ferrihydrite [a poorly crystalline Fe(III) oxide]. Each gene cluster encodes a putative transcriptional factor (OrfR/OrfS), a porin-like outer-membrane protein (OmbB/OmbC), a periplasmic c-type cytochrome (c-Cyt, OmaB/OmaC) and an outer-membrane c-Cyt (OmcB/OmcC). The individual roles of OmbB, OmaB and OmcB in extracellular reduction of Fe(III), however, have remained either uninvestigated or controversial. Here, we showed that replacements of ombB, omaB, omcB and ombB-omaB with an antibiotic gene in the presence of ombC-omaC-omcC had no impact on reduction of Fe(III)-citrate by G. sulfurreducens PCA. Disruption of ombB, omaB, omcB and ombB-omaB in the absence of ombC-omaC-omcC, however, severely impaired the bacterial ability to reduce Fe(III)-citrate as well as ferrihydrite. These results unequivocally demonstrate an overlapping role of ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction by G. sulfurreducens PCA. Involvement of both ombB-omaB-omcB and ombC-omaC-omcC in extracellular Fe(III) reduction reflects the importance of these trans-outer membrane protein complexes in the physiology of this bacterium. Moreover, the kinetics of Fe(III)-citrate and ferrihydrite reduction by these mutants in the absence of ombC-omaC-omcC were nearly identical, which clearly show that OmbB, OmaB and OmcB contribute equally to extracellular Fe(III) reduction. Finally, orfS was found to have a negative impact on the extracellular reduction of Fe(III)-citrate and ferrihydrite in G. sulfurreducens PCA probably by serving as a transcriptional repressor.

  5. The ADVANCE project: Formal evaluation of the targeted deployment. Volume 2

    SciTech Connect (OSTI)

    1997-01-01

    The ADVANCE familiar driver test provided a small sample of drivers familiar with their local road network and patterns of recurring congestion with an opportunity to drive a vehicle equipped with the ADVANCE dynamic route guidance system for a period of two weeks of normal use. On the basis of this test experience, drivers were asked to evaluate the ADVANCE system and to assess the value of features for future in-vehicle route guidance systems. This test involved 80 volunteer households living in the ADVANCE test area in northwest suburban Chicago; 110 drivers from these households used the ADVANCE vehicle and responded to both baseline (pre-test) and post-test surveys. Thirty two of these drivers participated in focus groups. Drivers also maintained written logs describing their rerouting experiences with the ADVANCE system.

  6. Fact #567: April 20, 2009 Cars are Growing Older

    Broader source: Energy.gov [DOE]

    The median age of cars continues to grow in 2008 while the median age of light trucks has remained fairly constant over the last ten years. The average age for all trucks, which includes heavy...

  7. Structure of continental rifts: Role of older features and magmatism

    SciTech Connect (OSTI)

    Keller, G.R.

    1996-12-31

    Recent geological and geophysical studies in several continental rifts have begun to shed light on the details of the processes which govern the structural evolution of these important exploration targets. In Kenya and Tanzania, the classic East African rift has been the object of several investigations which reveal that its location follows the boundary (suture ?) between the Tanzanian craton (Archean) and Mozambiquan belt (Proterozoic), The Baikal rift also follows a similar boundary, and the Mid-continent rift of North America appears to do the same. Rifts themselves often act as zones of weakness which are reactivated by younger tectonic regimes. The classic North American example of this effect is the Eocambrian Southern Oklahoma aulacogen which was deformed to create the Anadarko basin and Wichita uplift in the late Paleozoic. The Central basin platform has a similar history although the original rift formed at {approximately}1,100Ma. Integration of geophysical data with petrologic and geochemical data from several rift zones has also provided a new picture of the nature and extent of magmatic modification of the crust. An interesting contradiction is that Phanerozoic rifts, except the Afar region, show little evidence for major magmatic modification of the crust whereas, at least in North America, many Precambrian rifts are associated with very large mafic bodies in the crust. The Kenya rift displays evidence for modification of the lower crust in a two-phase magmatic history, but upper crustal magmatic features are limited to local intrusions associated with volcanoes. In this rift, complex basement structure plays a much more important role than previously realized, and the geophysical signatures of basement structure and magmatism are easy to confuse. If this is also the case in other rifts, additional rift basins remain to be discovered.

  8. Structure of continental rifts: Role of older features and magmatism

    SciTech Connect (OSTI)

    Keller, G.R. )

    1996-01-01

    Recent geological and geophysical studies in several continental rifts have begun to shed light on the details of the processes which govern the structural evolution of these important exploration targets. In Kenya and Tanzania, the classic East African rift has been the object of several investigations which reveal that its location follows the boundary (suture ) between the Tanzanian craton (Archean) and Mozambiquan belt (Proterozoic), The Baikal rift also follows a similar boundary, and the Mid-continent rift of North America appears to do the same. Rifts themselves often act as zones of weakness which are reactivated by younger tectonic regimes. The classic North American example of this effect is the Eocambrian Southern Oklahoma aulacogen which was deformed to create the Anadarko basin and Wichita uplift in the late Paleozoic. The Central basin platform has a similar history although the original rift formed at [approximately]1,100Ma. Integration of geophysical data with petrologic and geochemical data from several rift zones has also provided a new picture of the nature and extent of magmatic modification of the crust. An interesting contradiction is that Phanerozoic rifts, except the Afar region, show little evidence for major magmatic modification of the crust whereas, at least in North America, many Precambrian rifts are associated with very large mafic bodies in the crust. The Kenya rift displays evidence for modification of the lower crust in a two-phase magmatic history, but upper crustal magmatic features are limited to local intrusions associated with volcanoes. In this rift, complex basement structure plays a much more important role than previously realized, and the geophysical signatures of basement structure and magmatism are easy to confuse. If this is also the case in other rifts, additional rift basins remain to be discovered.

  9. A Preliminary Study Of Older Hot Spring Alteration In Sevenmile...

    Open Energy Info (EERE)

    Caldera ring fault across the northern part of the Caldera. Authors Peter B. Larson, Allison Phillips, David John, Michael Cosca, Chad Pritchard, Allen Andersen and...

  10. Travel Patterns and Characteristics of Elderly Subpopulation in New York State

    SciTech Connect (OSTI)

    Hwang, Ho-Ling; Wilson, Daniel W.; Reuscher, Tim; Yang, Jianjiang; Taylor, Rob D.; Chin, Shih-Miao

    2015-03-01

    With the increasing demographic shift towards a larger population of elderly (individuals 65 years and older), it is essential for policy makers and planners to have an understanding of transportation issues that affect the elderly. These issues include livability of the community, factors impacting travel behavior and mobility, transportation safety, etc. In this study, Oak Ridge National Laboratory was tasked by the New York State (NYS) Department of Transportation to conduct a detailed examination of travel behaviors, and identify patterns and trends of the elderly within NYS. The National Household Travel Survey (NHTS) was used as the primary data source to analyze subjects and address questions such as: Are there differences in traveler demographics between the elderly population and those of younger age groups who live in various NYS regions; e.g., New York City, other urban areas of NYS, or other parts of the country? How do they compare with the population at large? Are there any regional differences (e.g., urban versus rural)? Gender differences? Do any unique travel characteristics or patterns exist within the elderly group? In addition to analysis of NHTS data, roadway travel safety concerns associated with elderly travelers were also investigated in this study. Specifically, data on accidents involving the elderly (including drivers, passengers, and others) as captured in the Fatal Analysis Reporting System (FARS) database was analyzed to examine elderly driver and elderly pedestrian travel safety issues in NYS. The analyses of these data sets provide a greater understanding of the elderly within NYS and their associated transportation issues. Through this study, various key findings on elderly population size, household characteristics, and travel patterns were produced and are report herein this report.

  11. Regulatory trends involving pumps and valves

    SciTech Connect (OSTI)

    Thadani, A.C.

    1996-12-01

    The long-standing inservice testing program is well established, but there are a number of activities that are creating dynamics in the program that could change the way it is developed and implemented by licensees: (1) the move toward risk-informed and performance-based regulation, (2) proposed changes to the governing regulations, and (3) the Maintenance Rule. Underlying all of the activities is the imminent deregulation of the electric utility industry of which everyone must be aware, but for which one cannot sacrifice safety for costs. The author discusses some of these factors in light of the changing environment.

  12. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs Education Programs Contribution Programs Volunteer Programs Education Programs Cyber Technologies Academy CroSSlinks Science Volunteers DOE Regional Science Bowls Family Math Night Family Science Night Science, Technology, Engineering, and Math Programs About Education Programs Inspiring the next generation of scientists and engineers Nitrogen photo Sandia National Laboratories provides innovative, science-based, systems-engineering solutions to our nation's most

  13. Public Involvement in the Environmental Assessment Process

    Broader source: Energy.gov [DOE]

    A DOE policy regarding the online publication and electronic notification of the availability of draft environmental assessments (EAs) for public comment.

  14. UT gets involved at Oak Ridge

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The struggle to maintain the momentum built up winning World War II and to keep the scientific brain trust at the Clinton Laboratories built during that amazing world changing ...

  15. SMR Handbook: Hybrid Energy Systems Involving SMRs

    SciTech Connect (OSTI)

    Shannon M. Bragg-Sitton

    2014-09-01

    Large-scale nuclear reactors are traditionally operated for a singular purpose: steady-state production of dispatchable baseload electricity that is distributed broadly on the electric grid. While this implementation is key to a sustainable, reliable energy grid, SMRs offer new opportunities for increased use of clean nuclear energy for both electric and thermal applications in more locations – while still accommodating the desire to support renewable production sources. This chapter considers a scenario in which renewable generation would be tightly coupled with the nuclear generation source – behind the grid – to meet the grid demand as an integrated energy system while simultaneously producing other commodities with the available thermal energy.

  16. Accurate Numerical Simulations Of Chemical Phenomena Involved...

    Office of Scientific and Technical Information (OSTI)

    Authors: Harrison, R.J. ; Vzquez-Mayagoitia, A. ; Hammond, J.R. 1 ; Stony Brook University) 2 + Show Author Affiliations (LCF) LCF ( Publication Date: 2013-09-16 OSTI ...

  17. OREM continues involvement with workforce development program

    Broader source: Energy.gov [DOE]

    For the third consecutive year, OREM has partnered with the NNSA to participate in a 10-week workforce development program for college interns.

  18. A Good Neighbor: Community Involvement | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of 470,000 for the 2013-14 Charitable Giving Campaign. Photo of deer walking through solar panel field at south table mountain NREL campus on the mesa. Environmental...

  19. RAPID/Get Involved | Open Energy Information

    Open Energy Info (EERE)

    join us as a contributor or attend one of our upcoming meetings. Be a Contributor Update.jpg RAPID OpenEI Tutorial.pdf Please feel free to log in to OpenEI and make content...

  20. Public Involvement and Communications Committee - Transcribed...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and implications o Focus on progress o Explain outcomes of CD when available Page 1 Lessons Learned Start with LCD (general public that doesn't know anything about...

  1. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs: CroSSlinks Science Volunteers CroSSlinks Science Volunteers The CroSSlinks program, sponsored by Sandia and Lockheed Martin, links the science community with schools to improve science education for Albuquerque students. The program continues Sandia's commitment to the effective utilization of inquiry-based science instruction. Volunteers partner with teachers to advance the teaching of hands-on science in support of district standards and required curriculum. Science

  2. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs: DOE Science Bowl DOE Regional Science Bowls You are invited to compete in the high school (9th-12th grades) or middle school (6th-8th grades) 2017 Regional Science Bowl competitions scheduled for New Mexico. The Science Bowl is a Jeopardy-like event for high school and middle school students who have a strong interest and academic ability in mathematics and science. The Science Bowl competition is in the form of a round robin in the morning and double elimination after

  3. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs: DOE Science Bowl Math Night Family Math Night Family Math Night provides an evening of hands-on math activities held at local elementary schools. Students and parents work together on fun math games and activities. Sandia provides all materials and instructions. Availability is limited, so reserve your Family Math Night today! Contact Albuquerque, NM Tineca Quintana (505) 284-5200 tdquint@sandia.gov

  4. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Education Programs: Family Science Night Science Night Family Science Night Family Science Night provides an evening of hands-on science activities held at local elementary schools in the Albuquerque, NM and Livermore, CA communities. Students and parents work together to conduct simple inquiry-based science activities. All materials and instructions (English and Spanish) are provided. For schools outside of our communities, we offer the following resources to help you host your own Family

  5. Public Involvement Plan | Department of Energy

    Energy Savers [EERE]

    2008 | Department of Energy Protecting Intelligent Distributed Power Grids Against Cyber Attacks - May 2008 Protecting Intelligent Distributed Power Grids Against Cyber Attacks - May 2008 Development of a novel distributed and hierarchical security layer specific to intelligent grid design will help protect intelligent distributed power grids from cyber attacks. Intelligent power grids are interdependent energy management systems-encompassing generation, distribution, IT networks, and

  6. Sandia National Laboratories: About Sandia: Community Involvement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    gifts to nearly 500 needy families. A unique giving program at Sandia is our on-site, blood drives. These convenient drives facilitate the donation of over 900 units of blood...

  7. Sandia National Laboratories: About Sandia: Community Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    passionate about volunteering. You'll find Sandians judging science fairs, coaching sports teams, leading scouting troops, sorting food, building houses, and serving on...

  8. Fukushima Media Involvement: Lessons Learned and Challenges

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Koller, Greg L.; Johnson, Wayne L.

    2013-04-01

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the Department of Energy’s Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Within days, PNNL had set up a technical team in support of the U.S. government’s efforts to assist the devastated country. While a vast amount of information began to flow from Japan, the situation rapidly evolved challenging PNNL scientists and engineers, as well as news media and the general public to deal with a complex and often conflicting information stream. Over the course of about three weeks, PNNL’s News & Media Relations staff and its scientists and engineers responded to more than one hundred requests for information, and engaged in dozens of personal interviews with international, national, regional and local media. While many of the interviews and resulting stories were accurate and well done, to say that all communication went flawless would be far from the truth. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Even when communications guidelines are established and agreed-to ahead of time, and spokespeople promise to stay on message and within their areas of expertise, there is no guarantee the ball will not be dropped on occasion. Addressed here is “the rest of the story.”

  9. Local employee honored for community involvement

    Office of Energy Efficiency and Renewable Energy (EERE)

    Last month, the East Tennessee Economic Council (ETEC) recognized Colin Colverson, an Energy Department attorney in Oak Ridge, with the prestigious Postma Young Professional Medal. The selection committee chooses an annual recipient for the award that displays elite community service and leadership qualities.

  10. Sandia National Laboratories: About Sandia: Community Involvement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Awards reward young people who, through hard work and determination, overcome great personal difficulties to achieve their goals. Their achievements earn them roles as leaders...

  11. Sandia National Laboratories: About Sandia: Community Involvement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science, Technology, Engineering, and Math Programs Future scientists photo Our science, technology, engineering, and math (STEM) programs engage students by linking science to the ...

  12. Strategic Public Involvement … Tool Time!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liz Mattson, Hanford Challenge Engage the public early and often. Educate the public by providing timely, accurate, and understandable information. Incorporate public values in the decision making process and in the decisions made. Prepare future generations for informed engagement and participation. Ice Cream Socials Build a sense of community around Hanford (locally, regionally, and beyond). Ice Cream Socials  Organize Event: › Located in a place people are already gathering › Provide

  13. TPA_Draft_Public_Involvement_Plan.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  14. Decom project involves new tools, communication

    SciTech Connect (OSTI)

    1996-05-01

    This article is the May 1996 Power highlights. Included within this section are discussions of the following: (1) Ft. St. Vrain and Yankee Rowe decommissioning, (2) Stuck fuel assembly during refueling operations at PVNGS-2, (3) Restart schedules for Salem-1 & -2 and Indian Point-3, and (4) Reactor vessel annealing demonstration at Marble Hill.

  15. Community Involvement Fund | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Requests for Proposals are issued at various times throughout the year. Eligible grantees include non-profit community organizations, groups, projects, or coalitions, who want to ...

  16. Community Involvement and Making a Difference

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Community Guidelines for Energy Emergencies Community Guidelines for Energy Emergencies Community Guidelines for Energy Emergencies Natural hazards like floods, hurricanes, tornadoes, and earthquakes, as well as man-made hazards like industrial accidents and acts of terrorism, can knock out power, cause fuel shortages, and disrupt natural gas service, putting our lives on hold. After a disaster strikes, government officials and energy companies must first make sure that critical infrastructure

  17. Accurate Numerical Simulations Of Chemical Phenomena Involved...

    Office of Scientific and Technical Information (OSTI)

    A paper copy of this document is also available for sale to the public from the National Technical Information Service, Springfield, VA at www.ntis.gov. Authors: Harrison, R.J. ; ...

  18. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  19. A reversible Renilla luciferase protein complementation assay for rapid identification of protein-protein interactions reveals the existence of an interaction network involved in xyloglucan biosynthesis in the plant Golgi apparatus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lund, C. H.; Bromley, J. R.; Stenbaek, A.; Rasmussen, R. E.; Scheller, H. V.; Sakuragi, Y.

    2014-10-18

    A growing body of evidence suggests that protein–protein interactions (PPIs) occur amongst glycosyltransferases (GTs) required for plant glycan biosynthesis (e.g. cell wall polysaccharides and N-glycans) in the Golgi apparatus, and may control the functions of these enzymes. However, identification of PPIs in the endomembrane system in a relatively fast and simple fashion is technically challenging, hampering the progress in understanding the functional coordination of the enzymes in Golgi glycan biosynthesis. To solve the challenges, we adapted and streamlined a reversible Renilla luciferase protein complementation assay (Rluc-PCA), originally reported for use in human cells, for transient expression in Nicotiana benthamiana. Wemore » tested Rluc-PCA and successfully identified luminescence complementation amongst Golgi-localizing GTs known to form a heterodimer (GAUT1 and GAUT7) and those which homooligomerize (ARAD1). In contrast, no interaction was shown between negative controls (e.g. GAUT7, ARAD1, IRX9). Rluc-PCA was used to investigate PPIs amongst Golgi-localizing GTs involved in biosynthesis of hemicelluloses. Although no PPI was identified among six GTs involved in xylan biosynthesis, Rluc-PCA confirmed three previously proposed interactions and identified seven novel PPIs amongst GTs involved in xyloglucan biosynthesis. Notably, three of the novel PPIs were confirmed by a yeast-based split-ubiquitin assay. Finally, Gateway-enabled expression vectors were generated, allowing rapid construction of fusion proteins to the Rluc reporters and epitope tags. In conclusion, our results show that Rluc-PCA coupled with transient expression in N. benthamiana is a fast and versatile method suitable for analysis of PPIs between Golgi resident proteins in an easy and mid-throughput fashion in planta.« less

  20. A reversible Renilla luciferase protein complementation assay for rapid identification of protein-protein interactions reveals the existence of an interaction network involved in xyloglucan biosynthesis in the plant Golgi apparatus

    SciTech Connect (OSTI)

    Lund, C. H.; Bromley, J. R.; Stenbaek, A.; Rasmussen, R. E.; Scheller, H. V.; Sakuragi, Y.

    2014-10-18

    A growing body of evidence suggests that protein–protein interactions (PPIs) occur amongst glycosyltransferases (GTs) required for plant glycan biosynthesis (e.g. cell wall polysaccharides and N-glycans) in the Golgi apparatus, and may control the functions of these enzymes. However, identification of PPIs in the endomembrane system in a relatively fast and simple fashion is technically challenging, hampering the progress in understanding the functional coordination of the enzymes in Golgi glycan biosynthesis. To solve the challenges, we adapted and streamlined a reversible Renilla luciferase protein complementation assay (Rluc-PCA), originally reported for use in human cells, for transient expression in Nicotiana benthamiana. We tested Rluc-PCA and successfully identified luminescence complementation amongst Golgi-localizing GTs known to form a heterodimer (GAUT1 and GAUT7) and those which homooligomerize (ARAD1). In contrast, no interaction was shown between negative controls (e.g. GAUT7, ARAD1, IRX9). Rluc-PCA was used to investigate PPIs amongst Golgi-localizing GTs involved in biosynthesis of hemicelluloses. Although no PPI was identified among six GTs involved in xylan biosynthesis, Rluc-PCA confirmed three previously proposed interactions and identified seven novel PPIs amongst GTs involved in xyloglucan biosynthesis. Notably, three of the novel PPIs were confirmed by a yeast-based split-ubiquitin assay. Finally, Gateway-enabled expression vectors were generated, allowing rapid construction of fusion proteins to the Rluc reporters and epitope tags. In conclusion, our results show that Rluc-PCA coupled with transient expression in N. benthamiana is a fast and versatile method suitable for analysis of PPIs between Golgi resident proteins in an easy and mid-throughput fashion in planta.

  1. Small GTPase Rho signaling is involved in {beta}1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor {kappa}B ligand on osteoblasts and osteoclast maturation

    SciTech Connect (OSTI)

    Hirai, Fumihiko; Nakayamada, Shingo; Okada, Yosuke; Saito, Kazuyoshi; Kurose, Hitoshi; Mogami, Akira; Tanaka, Yoshiya . E-mail: tanaka@med.uoeh-u.ac.jp

    2007-04-27

    We assessed the characteristics of human osteoblasts, focusing on small GTPase Rho signaling. {beta}1 Integrin were highly expressed on osteoblasts. Engagement of {beta}1 integrins by type I collagen augmented expression of intercellular adhesion molecule 1 (ICAM-1) and receptor activator of nuclear factor {kappa}B ligand (RANKL) on osteoblasts. Rho was activated by {beta}1 stimulation in osteoblasts. {beta}1 Integrin-induced up-regulation of ICAM-1 and RANKL was inhibited by transfection with adenoviruses encoding C3 transferase or pretreated with Y-27632, specific Rho and Rho-kinase inhibitors. Engagement of {beta}1 integrin on osteoblasts induced formation of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNC) in a coculture system of osteoblasts and peripheral monocytes, but this action was completely abrogated by transfection of C3 transferase. Our results indicate the direct involvement of Rho-mediated signaling in {beta}1 integrin-induced up-regulation of ICAM-1 and RANKL and RANKL-dependent osteoclast maturation. Thus, Rho-mediated signaling in osteoblasts seems to introduce major biases to bone resorption.

  2. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  3. Implementation of an ex situ stabilization technique at the Sand Springs superfund site to solidify and stabilize acid tar sludges involving a quick-lime based stabilization process and innovative equipment design

    SciTech Connect (OSTI)

    McManus, R.W.; Grajczak, P.; Wilcoxson, J.C.; Webster, S.D.

    1997-12-31

    An old refinery site was safely remediated a year before schedule and for 25% less than final engineering estimates for the stabilization remedy thanks to energetic project management and innovative design involving ex situ stabilization/solidification of acid tar sludges. A quicklime based process, Dispersion by Chemical Reaction (DCR{trademark}), was employed to solidify and stabilize (SS) over 103,000 cubic meters (135,000 cubic yards) of petroleum waste, mostly acidic tarry sludge. The SS process was selected over competing methods because it afforded minimal volume increase, could readily achieve Record of Decision (ROD) specified physical and chemical treatment goals, could be implemented with treatment equipment that minimized emissions, and could be performed with low reagent usage and at low cost. To ensure treatment goals were achieved and an accelerated schedule met, a custom designed and fabricated transportable treatment unit (TTU) was employed to implement the process. The treated material was visually soil-like in character, it was left in stockpiles for periods of time, and it was placed and compacted in the on site landfill using standard earth-moving equipment.

  4. Plugged In: Understanding How and Where Plug-in Electric Vehicle Drivers Charge Up

    Broader source: Energy.gov [DOE]

    Being able to go on long trips running on electricity has always been the Holy Grail of plug-in electric vehicle (PEV) owners. In comparison to conventional vehicles, which can run for 300 miles or...

  5. Vehicle Technologies Office Merit Review 2016: Gate Driver Optimization for WBG Applications

    Broader source: Energy.gov [DOE]

    Presentation given by Oak Ridge National Laboratory (ORNL) at the 2016 DOE Vehicle Technologies Office and Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting about...

  6. Impact of beam transport method on chamber and driver design for heavy ion inertial fusion energy

    SciTech Connect (OSTI)

    Rose, D.V.; Welch, D.R.; Olson, C.L.; Yu, S.S.; Neff, S.; Sharp, W.M.

    2002-12-01

    In heavy ion inertial fusion energy systems, intense beams of ions must be transported from the exit of the final focus magnet system through the target chamber to hit millimeter spot sizes on the target. In this paper, we examine three different modes of beam propagation: neutralized ballistic transport, assisted pinched transport, and self-pinched transport. The status of our understanding of these three modes is summarized, and the constraints imposed by beam propagation upon the chamber environment, as well as their compatibility with various chamber and target concepts, are considered. We conclude that, on the basis of our present understanding, there is a reasonable range of parameter space where beams can propagate in thick-liquid wall, wetted-wall, and dry-wall chambers.

  7. Offshore Wind Plant Balance-of-Station Cost Drivers and Sensitivities (Poster)

    SciTech Connect (OSTI)

    Saur, G.; Maples, B.; Meadows, B.; Hand, M.; Musial, W.; Elkington, C.; Clayton, J.

    2012-09-01

    With Balance of System (BOS) costs contributing up to 70% of the installed capital cost, it is fundamental to understanding the BOS costs for offshore wind projects as well as potential cost trends for larger offshore turbines. NREL developed a BOS model using project cost estimates developed by GL Garrad Hassan. Aspects of BOS covered include engineering and permitting, ports and staging, transportation and installation, vessels, foundations, and electrical. The data introduce new scaling relationships for each BOS component to estimate cost as a function of turbine parameters and size, project parameters and size, and soil type. Based on the new BOS model, an analysis to understand the non-turbine costs associated with offshore turbine sizes ranging from 3 MW to 6 MW and offshore wind plant sizes ranging from 100 MW to 1000 MW has been conducted. This analysis establishes a more robust baseline cost estimate, identifies the largest cost components of offshore wind project BOS, and explores the sensitivity of the levelized cost of energy to permutations in each BOS cost element. This presentation shows results from the model that illustrates the potential impact of turbine size and project size on the cost of energy from US offshore wind plants.

  8. Open-access databases as unprecedented resources and drivers of cultural change in fisheries science

    SciTech Connect (OSTI)

    McManamay, Ryan A; Utz, Ryan

    2014-01-01

    Open-access databases with utility in fisheries science have grown exponentially in quantity and scope over the past decade, with profound impacts to our discipline. The management, distillation, and sharing of an exponentially growing stream of open-access data represents several fundamental challenges in fisheries science. Many of the currently available open-access resources may not be universally known among fisheries scientists. We therefore introduce many national- and global-scale open-access databases with applications in fisheries science and provide an example of how they can be harnessed to perform valuable analyses without additional field efforts. We also discuss how the development, maintenance, and utilization of open-access data are likely to pose technical, financial, and educational challenges to fisheries scientists. Such cultural implications that will coincide with the rapidly increasing availability of free data should compel the American Fisheries Society to actively address these problems now to help ease the forthcoming cultural transition.

  9. A Hybrid Ion Source Concept for a Proton Driver Front End

    SciTech Connect (OSTI)

    Keller, R.; Luft, P.; Regis, M.; Wallig, J.; Monroy, M.; Ratti, A.; Syversrud, D.; Welton, R.; Anderson, D.

    2005-06-08

    A novel concept for creating intense beams of negative hydrogen ion beams has been devised, and first steps towards its realization have been taken. In this approach, an ECR plasma generator operating at 2.45 GHz frequency is utilized as a plasma cathode, and electrons are extracted instead of ions and injected at moderate energy into an SNS-type multi-cusp H- ion source. This secondary source is then driven by chopped d. c. power, rather than rf power, but does not need filaments which are the cause for the rather short lifetime of conventional H- sources. The development of this ion source is primarily aimed at the future beam-power goal of 3 MW for the Spallation Neutron Source (SNS) that will be pursued after the start of SNS operations. The first two phases of this development effort have been successfully passed: assembly of a test stand and verification of the performance of an rf-driven SNS ion-source prototype and extraction of electrons with more than 200 mA current from a 2.45-GHz ECR ion source obtained on loan from Argonne National Laboratory. An electron-extraction chamber that joins these ECR and H- sources has been fabricated, and the next goal is the demonstration of actual H- ion production by this novel, hybrid ion source. This paper describes the source principle and design in detail, reports on the current status of the development work, and gives an outlook on future lines of development.

  10. Modeling of Uncertainties in Major Drivers in U.S. Electricity Markets: Preprint

    SciTech Connect (OSTI)

    Short, W.; Ferguson, T.; Leifman, M.

    2006-09-01

    This paper presents information on the Stochastic Energy Deployment System (SEDS) model. DOE and NREL are developing this new model, intended to address many of the shortcomings of the current suite of energy models. Once fully built, the salient qualities of SEDS will include full probabilistic treatment of the major uncertainties in national energy forecasts; code compactness for desktop application; user-friendly interface for a reasonably trained analyst; run-time within limits acceptable for quick-response analysis; choice of detailed or aggregate representations; and transparency of design, code, and assumptions. Moreover, SEDS development will be increasingly collaborative, as DOE and NREL will be coordinating with multiple national laboratories and other institutions, making SEDS nearly an 'open source' project. The collaboration will utilize the best expertise on specific sectors and problems, and also allow constant examination and review of the model. This paper outlines the rationale for this project and a description of its alpha version, as well as some example results. It also describes some of the expected development efforts in SEDS.

  11. Vehicle Technologies Office Merit Review 2014: Accelerating Alternatives for Minnesota Drivers

    Broader source: Energy.gov [DOE]

    Presentation given by American Lung Association of the Upper Midwest at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting...

  12. Wind Power Project Repowering: Financial Feasibility, Decision Drivers, and Supply Chain Effects

    SciTech Connect (OSTI)

    Lantz, E.; Leventhal, M.; Baring-Gould, I.

    2013-12-01

    As wind power facilities age, project owners are faced with plant end of life decisions. This report is intended to inform policymakers and the business community regarding the history, opportunities, and challenges associated with plant end of life actions, in particular repowering. Specifically, the report details the history of repowering, examines the plant age at which repowering becomes financially attractive, and estimates the incremental market investment and supply chain demand that might result from future U.S. repowering activities.

  13. Land-Based Wind Plant Balance-of-System Cost Drivers and Sensitivities (Poster)

    SciTech Connect (OSTI)

    Mone, C.; Maples, B.; Hand, M.

    2014-04-01

    With Balance of System (BOS) costs contributing up to 30% of the installed capital cost, it is fundamental to understand the BOS costs for wind projects as well as potential cost trends for larger turbines. NREL developed a BOS model using project cost estimates developed by industry partners. Aspects of BOS covered include engineering and permitting, foundations for various wind turbines, transportation, civil work, and electrical arrays. The data introduce new scaling relationships for each BOS component to estimate cost as a function of turbine parameters and size, project parameters and size, and geographic characteristics. Based on the new BOS model, an analysis to understand the non‐turbine wind plant costs associated with turbine sizes ranging from 1-6 MW and wind plant sizes ranging from 100-1000 MW has been conducted. This analysis establishes a more robust baseline cost estimate, identifies the largest cost components of wind project BOS, and explores the sensitivity of the capital investment cost and the levelized cost of energy to permutations in each BOS cost element. This presentation shows results from the model that illustrate the potential impact of turbine size and project size on the cost of energy from US wind plants.

  14. PROPERTIES OF A CORONAL SHOCK WAVE AS A DRIVER OF EARLY SEP ACCELERATION

    SciTech Connect (OSTI)

    Kozarev, K. A.; Raymond, J. C.; Lobzin, V. V.; Hammer, M.

    2015-02-01

    Coronal mass ejectmons (CMEs) are thought to drive collisionless shocks in the solar corona, which in turn have been shown to be capable of accelerating solar energetic particles (SEPs) in minutes. It has been notoriously difficult to extract information about energetic particle spectra in the corona, owing to a lack of in situ measurements. It is possible, however, to combine remote observations with data-driven models in order to deduce coronal shock properties relevant to the local acceleration of SEPs and their heliospheric connectivity to near-Earth space. We present such novel analysis applied to the 2011 May11 CME event on the western solar limb, focusing on the evolution of the eruption-driven, dome-like shock wave observed by the Atmospheric Imaging Assembly (AIA) EUV telescopes on board the Solar Dynamics Observatory spacecraft. We analyze the shock evolution and estimate its strength using emission measure modeling. We apply a new method combining a geometric model of the shock front with a potential field source surface model to estimate time-dependent field-to-shock angles and heliospheric connectivity during shock passage in the low corona. We find that the shock was weak, with an initial speed of ?450 km s{sup 1}. It was initially mostly quasi-parallel, but a significant portion of it turned quasi-perpendicular later in the event. There was good magnetic connectivity to near-Earth space toward the end of the event as observed by the AIA instrument. The methods used in this analysis hold a significant potential for early characterization of coronal shock waves and forecasting of SEP spectra based on remote observations.

  15. Arc plasma generator of atomic driver for steady-state negative ion source

    SciTech Connect (OSTI)

    Ivanov, A. A.; Belchenko, Yu. I.; Davydenko, V. I.; Novosibirsk State University, Novosibirsk ; Ivanov, I. A.; Kolmogorov, V. V.; Listopad, A. A. Mishagin, V. V.; Shulzhenko, G. I.; Putvinsky, S. V.; Smirnov, A.

    2014-02-15

    The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB{sub 6} cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.

  16. U.S. Balance-of-Station Cost Drivers and Sensitivities (Presentation)

    SciTech Connect (OSTI)

    Maples, B.

    2012-10-01

    With balance-of-system (BOS) costs contributing up to 70% of the installed capital cost, it is fundamental to understanding the BOS costs for offshore wind projects as well as potential cost trends for larger offshore turbines. NREL developed a BOS model using project cost estimates developed by GL Garrad Hassan. Aspects of BOS covered include engineering and permitting, ports and staging, transportation and installation, vessels, foundations, and electrical. The data introduce new scaling relationships for each BOS component to estimate cost as a function of turbine parameters and size, project parameters and size, and soil type. Based on the new BOS model, an analysis to understand the non‐turbine costs has been conducted. This analysis establishes a more robust baseline cost estimate, identifies the largest cost components of offshore wind project BOS, and explores the sensitivity of the levelized cost of energy to permutations in each BOS cost element. This presentation shows results from the model that illustrates the potential impact of turbine size and project size on the cost of energy from U.S. offshore wind plants.

  17. Formation of imploding plasma liners for fundamental HEDP studies and MIF Standoff Driver Concept

    SciTech Connect (OSTI)

    Cassibry, Jason; Hatcher, Richard; Stanic, Milos

    2013-08-17

    The disciplines of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) are characterized by hypervelocity implosions and strong shocks. The Plasma Liner Experiment (PLX) is focused on reaching HEDP and/or ICF relevant regimes in excess of 1 Mbar peak pressure by the merging and implosion of discrete plasma jets, as a potentially efficient path towards these extreme conditions in a laboratory. In this work we have presented the first 3D simulations of plasma liner, formation, and implosion by the merging of discrete plasma jets in which ionization, thermal conduction, and radiation are all included in the physics model. The study was conducted by utilizing a smoothed particle hydrodynamics code (SPHC) and was a part of the plasma liner experiment (PLX). The salient physics processes of liner formation and implosion are studied, namely vacuum propagation of plasma jets, merging of the jets (liner forming), implosion (liner collapsing), stagnation (peak pressure), and expansion (rarefaction wave disassembling the target). Radiative transport was found to significantly reduce the temperature of the liner during implosion, thus reducing the thermal leaving more pronounced gradients in the plasma liner during the implosion compared with ideal hydrodynamic simulations. These pronounced gradients lead to a greater sensitivity of initial jet geometry and symmetry on peak pressures obtained. Accounting for ionization and transport, many cases gave higher peak pressures than the ideal hydrodynamic simulations. Scaling laws were developed accordingly, creating a non-dimensional parameter space in which performance of an imploding plasma jet liner can be estimated. It is shown that HEDP regimes could be reached with ~ 5 MJ of liner energy, which would translate to roughly 10 to 20 MJ of stored (capacitor) energy. This is a potentially significant improvement over the currently available means via ICF of achieving HEDP and nuclear fusion relevant parameters.

  18. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer

    SciTech Connect (OSTI)

    Hong, Matthew K. H.; Macintyre, Geoff; Wedge, David C.; Van Loo, Peter; Patel, Keval; Lunke, Sebastian; Alexandrov, Ludmil B.; Sloggett, Clare; Cmero, Marek; Marass, Francesco; Tsui, Dana; Mangiola, Stefano; Lonie, Andrew; Naeem, Haroon; Sapre, Nikhil; Phal, Pramit M.; Kurganovs, Natalie; Chin, Xiaowen; Kerger, Michael; Warren, Anne Y.; Neal, David; Gnanapragasam, Vincent; Rosenfeld, Nitzan; Pedersen, John S.; Ryan, Andrew; Haviv, Izhak; Costello, Anthony J.; Corcoran, Niall M.; Hovens, Christopher M.

    2015-04-01

    Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours. We find one case of metastatic spread to the surgical bed causing local recurrence, and another case of cross-metastatic site seeding combining with dynamic remoulding of subclonal mixtures in response to therapy. By ultra-deep sequencing end-stage blood, we detect both metastatic and primary tumour clones, even years after removal of the prostate. As a result, analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations, and additional sequencing of metastases from 19 patients demonstrates that acquisition of TP53 mutations is linked with the expansion of subclones with metastatic potential which we can detect in the blood.

  19. Advanced Power Electronics for LED Drivers: Advanced Technologies for integrated Power Electronics

    SciTech Connect (OSTI)

    2010-09-01

    ADEPT Project: MIT is teaming with Georgia Institute of Technology, Dartmouth College, and the University of Pennsylvania (UPenn) to create more efficient power circuits for energy-efficient light-emitting diodes (LEDs) through advances in 3 related areas. First, the team is using semiconductors made of high-performing gallium nitride grown on a low-cost silicon base (GaN-on-Si). These GaN-on-Si semiconductors conduct electricity more efficiently than traditional silicon semiconductors. Second, the team is developing new magnetic materials and structures to reduce the size and increase the efficiency of an important LED power component, the inductor. This advancement is important because magnetics are the largest and most expensive part of a circuit. Finally, the team is creating an entirely new circuit design to optimize the performance of the new semiconductors and magnetic devices it is using.

  20. Look-ahead Driver Feedback and Powertrain Management | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    A photo of a man and a woman looking at plans for a home. Clean Energy Works in Portland, Oregon, has become so good at enticing homeowners to complete energy efficiency evaluations and upgrades that some contractors are politely asking for the projects to slow down a bit. Clean Energy Works hit the ground running by launching its program with significant rebate offers to residents. However, the rebates were so successful in driving demand for the program that contractors began to get

  1. Use of the National Driver Register in the U.S. Department of...

    Office of Scientific and Technical Information (OSTI)

    DOE Contract Number: DE-AC05-06OR23100 Resource Type: Technical Report Research Org: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN Sponsoring Org: USDOE - ...

  2. A Muon Source Proton Driver at JPARC-based Parameters (Conference...

    Office of Scientific and Technical Information (OSTI)

    Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States) Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of ...

  3. Drivers of U.S. Household Energy Consumption, 1980-2009 - Energy...

    Gasoline and Diesel Fuel Update (EIA)

    Because of the impacts of residential sector energy use on the environment and the economy, this study was undertaken to help provide a better understanding of the factors ...

  4. U.S. drivers continue to see low gasoline prices in December

    U.S. Energy Information Administration (EIA) Indexed Site

    Nationwide average gasoline price to fall below $2 a gallon in January The national average price of regular gasoline is expected to drop below $2 per gallon this month and hover near the $2 level through most of this year, as lower crude oil prices translate into more savings for consumers at the pump. In its new monthly forecast, the U.S. Energy Information Administration said the retail price for regular-grade gasoline averages $1.90 per gallon in February. That's the lowest level in seven

  5. Refueling Behavior of Flexible Fuel Vehicle Drivers in the Federal Fleet

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Refiners Switch to Reformulated Gasoline Complex Model Contents * Summary * Introduction o Table 1. Comparison of Simple Model and Complex Model RFG Per Gallon Requirements * Statutory, Individual Refinery, and Compliance Baselines o Table 2. Statutory Baseline Fuel Compositions * Simple Model * Complex Model o Table 3. Complex Model Variables * Endnotes Related EIA Short-Term Forecast Analysis Products * RFG Simple and Complex Model Spreadsheets * Areas Particpating in the Reformulated Gasoline

  6. RAVEN as Control Logic and Probabilistic Risk Assessment Driver for RELAP-7

    SciTech Connect (OSTI)

    C. Rabiti; A. Alfonsi; D. Mandelli; J. Cogliati; R. Martineau

    2012-11-01

    The Next Generation of System Analysis Code (NGSAC) [1] aims to model and simulate the Nuclear Power Plant (NPP) thermo-hydraulic behavior with high level of accuracy. In this respect, Idaho National Laboratory (INL) is developing a NGSAC (known as RELAP-7) which will allow to model NPP responses for a set of accident scenarios (e.g., loss of off-site power).

  7. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hong, Matthew K. H.; Macintyre, Geoff; Wedge, David C.; Van Loo, Peter; Patel, Keval; Lunke, Sebastian; Alexandrov, Ludmil B.; Sloggett, Clare; Cmero, Marek; Marass, Francesco; et al

    2015-04-01

    Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours. We find one case of metastatic spread to the surgical bed causing local recurrence, and another case of cross-metastatic site seeding combining with dynamic remoulding of subclonal mixtures in response to therapy. By ultra-deep sequencing end-stage blood, we detect both metastatic and primary tumour clones,more » even years after removal of the prostate. As a result, analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations, and additional sequencing of metastases from 19 patients demonstrates that acquisition of TP53 mutations is linked with the expansion of subclones with metastatic potential which we can detect in the blood.« less

  8. What kind of charging infrastructure do Nissan Leaf drivers in The EV Project use?

    SciTech Connect (OSTI)

    Shawn Salisbury

    2014-09-01

    This document will describe the charging behavior of Nissan Leaf battery electric vehicles that were enrolled in the EV Project. It will include aggregated data from several thousand vehicles regarding time-of-day, power level, and location of charging and driving events. This document is a white paper that will be published on the INL AVTA website.

  9. Use of the National Driver Register in the U.S. Department of...

    Office of Scientific and Technical Information (OSTI)

    Resource Type: Technical Report Research Org: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN ... Subject: 99 GENERAL AND MISCELLANEOUSMATHEMATICS, COMPUTING, ...

  10. Increasing Feedstock Production for Biofuels: Economic Drivers, Environmental Implications, and the Role of Research

    SciTech Connect (OSTI)

    none,

    2009-10-27

    The Biomass Research and Development Board (Board) commissioned an economic analysis of feedstocks to produce biofuels. The Board seeks to inform investments in research and development needed to expand biofuel production. This analysis focuses on feedstocks; other interagency teams have projects underway for other parts of the biofuel sector (e.g., logistics). The analysis encompasses feedstocks for both conventional and advanced biofuels from agriculture and forestry sources.

  11. Resonant acoustic transducer and driver system for a well drilling string communication system

    DOE Patents [OSTI]

    Chanson, Gary J.; Nicolson, Alexander M.

    1981-01-01

    The acoustic data communication system includes an acoustic transmitter and receiver wherein low frequency acoustic waves, propagating in relatively loss free manner in well drilling string piping, are efficiently coupled to the drill string and propagate at levels competitive with the levels of noise generated by drilling machinery also present in the drill string. The transmitting transducer incorporates a mass-spring piezoelectric transmitter and amplifier combination that permits self-oscillating resonant operation in the desired low frequency range.

  12. Update to industrial drivers in the AEO2015 as a result of new...

    U.S. Energy Information Administration (EIA) Indexed Site

    ... and not necessarily those of the U.S. Energy Information Administration. 6 Resins For ... visible in the smaller difference in the green lines in Figure 3. Agricultural chemicals ...

  13. H.R. 5299: A Bill to amend the Internal Revenue Code of 1986 to phase out the tax subsidies for alcohol fuels involving alcohol produced from feedstocks eligible to receive Federal agricultural subsidies. Introduced in the House of Representatives, One Hundred Third Congress, Second Session, November 29, 1994

    SciTech Connect (OSTI)

    1994-12-31

    The report H.R. 5299 is a bill to amend the Internal Revenue Code of 1986 to phase out the tax subsidies of alcohol fuels involving alcohol produced from feedstocks eligible to receive Federal agriculture subsidies. The proposed legislative text is included.

  14. Risk management considerations for seismic upgrading of an older facility for short-term residue stabilization

    SciTech Connect (OSTI)

    Additon, S.L.; Peregoy, W.L.; Foppe, T.L.

    1999-06-01

    Building 707 and its addition, Building 707A, were selected, after the production mission of Rocky Flats was terminated a few years ago, to stabilize many of the plutonium residues remaining at the site by 2002. The facility had undergone substantial safety improvements to its safety systems and conduct of operations for resumption of plutonium operations in the early 1990s and appeared ideally suited for this new mission to support accelerated Site closure. During development of a new authorization basis, a seismic evaluation was performed. This evaluation addressed an unanalyzed expansion joint and suspect connection details for the precast concrete tilt-up construction and concluded that the seismic capacity of the facility is less than half of that determined by previous analysis. Further, potential seismic interaction was identified between a collapsing Building 707 and the seismically upgraded Building 707A, possibly causing the partial collapse of the latter. Both the operating contractor and the Department of Energy sought a sound technical basis for deciding how to proceed. This paper addresses the risks of the as-is facility and possible benefits of upgrades to support a decision on whether to upgrade the seismic capacity of Building 707, accept the risk of the as-is facility for its short remaining mission, or relocate critical stabilization missions. The paper also addresses the Department of Energy`s policy on natural phenomena.

  15. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L.; Thilly, William G.

    1985-01-01

    A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

  16. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L.; Thilly, William G.

    1999-01-01

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

  17. The Department of Energy (DOE) is actively involved in leading...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    effectively operate the electricity delivery system by enabling advanced analysis, visualization, monitoring and alarming, and decision support capabilities for grid operators. ...

  18. GC GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM

    Energy Savers [EERE]

    ... source material' means (1) uranium, thorium, or any other material which is ... "source material " means ( 1) uranium, thorium , or any other material which is ...

  19. Memory and Spin Injection Devices Involving Half Metals (Journal...

    Office of Scientific and Technical Information (OSTI)

    Publisher: Hindawi Publishing Corporation Sponsoring Org: USDOE Country of Publication: Egypt Language: English Word Cloud More Like This Free Publicly Accessible Full Text ...

  20. Decontamination Dressdown at a Transportation Accident Involving Radioactive Material

    Broader source: Energy.gov [DOE]

    The purpose of this User’s Guide is to provide instructors with an overview of the key points covered in the video. The Student Handout portion of this Guide is designed to assist the instructor in...

  1. Probative Investigation of the Thermal Stability of Wastes Involved...

    Office of Environmental Management (EM)

    This document corresponds to Appendix FG: Reaction Chemistry & HypothesisSummary of Reactivity Testing of the Technical Assessment Team Report. Probative Investigation of the ...

  2. Metaproteomics Identifies the Protein Machinery Involved in Metal...

    Office of Scientific and Technical Information (OSTI)

    tools to identify biomarkers for monitoring microbial activity affecting U ... for site assessment, efficient implementation of bioremediation and long-term monitoring. ...

  3. MULTIOBJECTIVE OPTIMIZATION POWER GENERATION SYSTEMS INVOLVING CHEMICAL LOOPING COMBUSTION

    SciTech Connect (OSTI)

    Juan M. Salazar; Urmila M. Diwekar; Stephen E. Zitney

    2009-01-01

    Integrated Gasification Combined Cycle (IGCC) system using coal gasification is an important approach for future energy options. This work focuses on understading the system operation and optimizing it in the presence of uncertain operating conditions using ASPEN Plus and CAPE-OPEN compliant stochastic simulation and multiobjective optimization capabilities developed by Vishwamitra Research Institute. The feasible operating surface for the IGCC system is generated and deterministic multiobjective optimization is performed. Since the feasible operating space is highly non-convex, heuristics based techniques that do not require gradient information are used to generate the Pareto surface. Accurate CFD models are simultaneously developed for the gasifier and chemical looping combustion system to characterize and quantify the process uncertainty in the ASPEN model.

  4. The research performed during the last granting period involved...

    Office of Scientific and Technical Information (OSTI)

    Our most recent efforts have been on the brown rot fungus. We have grown these fungi on their woody substrates and isolated the mRNA for 454 sequencing. We recognized that this ...

  5. Mechanism involved in enhancement of osteoblast differentiation by hyaluronic acid

    SciTech Connect (OSTI)

    Kawano, Michinao; Ariyoshi, Wataru; Iwanaga, Kenjiro; Okinaga, Toshinori; Habu, Manabu; Yoshioka, Izumi; Tominaga, Kazuhiro; Nishihara, Tatsuji

    2011-02-25

    Research highlights: {yields} In this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. {yields} MG63 cells were incubated with BMP-2 and HA for various time periods. {yields} Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. {yields} HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation. -- Abstract: Objectives: Bone morphogenetic protein-2 (BMP-2) is expected to be utilized to fill bone defects and promote healing of fractures. However, it is unable to generate an adequate clinical response for use in bone regeneration. Recently, it was reported that glycosaminoglycans, including heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin-4-sulfate, chondroitin-6-sulfate, and hyaluronic acid (HA), regulate BMP-2 activity, though the mechanism by which HA regulates osteogenic activities has not been fully elucidated. The aim of this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. Materials and methods: Monolayer cultures of osteoblastic lineage MG63 cells were incubated with BMP-2 and HA for various time periods. To determine osteoblastic differentiation, alkaline phosphatase (ALP) activity in the cell lysates was quantified. Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by Western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. To further elucidate the role of HA in enhancement of BMP-2-induced Smad signaling, mRNA expressions of the BMP-2 receptor antagonists noggin and follistatin were detected using real-time RT-PCR. Results: BMP-2-induced ALP activation, Smad 1/5/8 phosphorylation, and nuclear translocation were up-regulated when MG63 cells were cultured with both BMP-2 and HA. Western blot analysis revealed that phosphorylation of ERK protein was diminished by HA. Furthermore, the mRNA expressions of noggin and follistatin induced by BMP-2 were preferentially blocked by HA. Conclusions: These results indicate that HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation.

  6. Numerical simulation of Rayleigh-Taylor instabilities involving solids

    SciTech Connect (OSTI)

    Chang, Chong H.

    2015-11-20

    This report is a description of research performed by LANL regarding numeric simulations of Rayleigh-Taylor instability.

  7. Consistent analysis of one-nucleon spectroscopic factors involving...

    Office of Scientific and Technical Information (OSTI)

    Additional Journal Information: Journal Volume: 757; Journal Issue: C; Related Information: CHORUS Timestamp: 2016-06-01 05:34:59; Journal ID: ISSN 0370-2693 Publisher: Elsevier ...

  8. OpenEI:Get Involved | Open Energy Information

    Open Energy Info (EERE)

    and contribute to OpenEI. Sign up for an account then start contributing wiki content Use social media to help share the word about OpenEI Join a local energy or technology...

  9. RAPID/Best Practices/Public Involvement | Open Energy Information

    Open Energy Info (EERE)

    - use a broad range of communication tools, including public meetings, a project website, social media accounts, press releases, advertisements in local newspapers and...

  10. Multidomain Carbohydrate-binding Proteins Involved in Bacteroides...

    Office of Scientific and Technical Information (OSTI)

    Starch Metabolism Authors: Cameron, Elizabeth A. ; Maynard, Mallory A. ; Smith, Christopher J. ; Smith, Thomas J. ; Koropatkin, Nicole M. ; Martens, Eric C. 1 ; Danforth) 2 + ...

  11. Drum Involved in Idaho Incident Not Shippable to WIPP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venting prevents this hydrogen buildup while the drum is being handled and transported. The Advanced -More- -2- Mixed Waste Treatment Facility routinely processes drums that have ...

  12. Biochemical localization of a protein involved in Gluconacetobacter...

    Office of Scientific and Technical Information (OSTI)

    States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES biofuels (including algae and biomass), bio-inspired, membrane, carbon sequestration, materials and chemistry by...

  13. Kinetics and mechanisms of reactions involving small aromatic reactive intermediates

    SciTech Connect (OSTI)

    Lin, M.C.

    1993-12-01

    Small aromatic radicals such as C{sub 6}H{sub 5}, C{sub 6}H{sub 5}O and C{sub 6}H{sub 4} are key prototype species of their homologs. C{sub 6}H{sub 5} and its oxidation product, C{sub 6}H{sub 5}O are believed to be important intermediates which play a pivotal role in hydrocarbon combustion, particularly with regard to soot formation. Despite their fundamental importance, experimental data on the reaction mechanisms and reactivities of these species are very limited. For C{sub 6}H{sub 5}, most kinetic data except its reactions with NO and NO{sub 2}, were obtained by relative rate measurements. For C{sub 6}H{sub 5}O, the authors have earlier measured its fragmentation reaction producing C{sub 5}H{sub 5} + CO in shock waves. For C{sub 6}H{sub 4}, the only rate constant measured in the gas phase is its recombination rate at room temperature. The authors have proposed to investigate systematically the kinetics and mechanisms of this important class of molecules using two parallel laser diagnostic techniques--laser resonance absorption (LRA) and resonance enhanced multiphoton ionization mass spectrometry (REMPI/MS). In the past two years, study has been focused on the development of a new multipass adsorption technique--the {open_quotes}cavity-ring-down{close_quotes} technique for kinetic applications. The preliminary results of this study appear to be quite good and the sensitivity of the technique is at least comparable to that of the laser-induced fluorescence method.

  14. Emergency Response to a Transportation Accident Involving Radioactive Material

    Office of Energy Efficiency and Renewable Energy (EERE)

    The purpose of this User’s Guide is to provide instructors with an overview of the key points covered in the video.  The Student Handout portion of this Guide is designed to assist the instructor...

  15. Weak interaction processes in nuclei involving neutrinos and CDM candidates

    SciTech Connect (OSTI)

    Kosmas, T. S.; Tsakstara, V. [Theoretical Physics Section, University of Ioannina, GR 45110 Ioannina (Greece); Divari, P. C. [Department of Physical Sciences, Hellenic Army Academy, Vari 16673, Attica (Greece); Sinatkas, J. [Department of Informatics and Computer Technology, TEI of Western Macedonia, GR-52100 Kastoria (Greece)

    2009-11-09

    In this work, we concentrate on the nuclear physics aspects of low-energy neutrinos and in particular on problems related to neutrino detection by terrestrial experiments, neutrino astrophysics and neutrino-nucleus interactions. The detection of low-flux neutrinos, feasible by measuring the energy recoil of the recoiling nucleus with gaseous-detectors having very-low threshold-energy, is carried out in conjunction with direct-detection of cold dark matter events and nonstandard physics searches like the neutrinoless double beta decay.

  16. FOIASI - Special Inquiry Review of Allegations InvolvingPotentialMisc...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    River Federal and contractor officials to access subcontractor personnel files for data mining of demographic information in violation of the procedures for protecting persondly ...

  17. Definite Integrals, Some Involving Residue Theory Evaluated by Maple Code

    SciTech Connect (OSTI)

    Bowman, Kimiko o [ORNL

    2010-01-01

    The calculus of residue is applied to evaluate certain integrals in the range (-{infinity} to {infinity}) using the Maple symbolic code. These integrals are of the form {integral}{sub -{infinity}}{sup {infinity}} cos(x)/[(x{sup 2} + a{sup 2})(x{sup 2} + b{sup 2}) (x{sup 2} + c{sup 2})]dx and similar extensions. The Maple code is also applied to expressions in maximum likelihood estimator moments when sampling from the negative binomial distribution. In general the Maple code approach to the integrals gives correct answers to specified decimal places, but the symbolic result may be extremely long and complex.

  18. Public Involvement in the Environmental Assessment Process (DOE, 2010)

    Broader source: Energy.gov [DOE]

    A DOE policy regarding the online publication and electronic notification of the availability of draft environmental assessments (EAs) for public comment.

  19. CHL1 is involved in human breast tumorigenesis and progression

    SciTech Connect (OSTI)

    He, Li-Hong; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Ma, Qin; Shi, Ye-Hui; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Ge, Jie; Zhao, Hong-Meng; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Li, Shu-Fen; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Tong, Zhong-Sheng; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin

    2013-08-23

    Highlights: CHL1 is down-regulation in breast cancer tissues. Down-regulation of CHL1 is related to high grade. Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression.

  20. Fukushima Media Involvement: Lessons Learned and Challenges - 13261

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Johnson, Wayne L.; Koller, Greg L.

    2013-07-01

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the DOE's Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following its announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Because PNNL develops state-of-the-art ultra-sensitive radionuclide detection and monitoring systems for national security applications, and has some of the equipment operating on its Richland campus, there was little surprise when one of these sophisticated systems led PNNL to be the first to detect measurable radionuclides in the United States. On Wednesday, March 16, 2011, that system detected minuscule levels of short-lived radioactive xenon, a telltale element derived from either weapons testing or a major reactor disruption. Immediately after the detection was announced, a flurry of inquiries nearly overwhelmed staff as governments, scientific organizations, the general public, and reporters struggled to understand and estimate what impacts this disaster might have on health and environment. Over the course of about three weeks, PNNL's News and Media Relations staff and its scientists and engineers responded to more than 100 requests for information, and engaged in dozens of personal interviews with international, national, regional, and local media. While many of the interviews and resulting stories were accurate and well done, not all communication went flawlessly. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Addressed here is 'the rest of the story'. (authors)