Sample records for involvement involvement involvement

  1. Parent Involvement

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10T23:59:59.000Z

    To be successful, a 4-H program must have parent involvement. Although 4-H leaders and Extension agents may interest young people in becoming members, they need the parents' goodwill and support to keep them interested, enthusiastic and active. Here...

  2. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor andPublic Involvement

  3. STUDENT EMPLOYMENT Student Involvement Outcomes

    E-Print Network [OSTI]

    de Lijser, Peter

    STUDENT EMPLOYMENT Student Involvement Outcomes reflective assessment High impact practices. Employment Structure ASI employs approximately 645 staff, interns, and volunteers on average during the fall and spring semesters. In spring 2013, ASI employed: · 42 Interns · 59 Professional Staff Members · 162

  4. Studies involving low protein broiler diets

    E-Print Network [OSTI]

    Parkin, David Palmer

    1971-01-01T23:59:59.000Z

    STUDIES INVOLVING L(% PROTEIN BROILER DIETS A Thesis by David Palmer Parkin Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1971 Major Subject...: Poultry Science STUDIES INVOLVING LS& PROTEIN BROILER DIETS A Thesis by David Palmer Parkin Approved as to style and content by: (Chairman of Commit e) ead of. Departmen Me er) (Member) (Memb ) May 1971 ABSTRACT Studies Involving Low Protein...

  5. The Leadership and Involvement Record Sponsored by the Center for Leadership and Involvement

    E-Print Network [OSTI]

    Sheridan, Jennifer

    The Leadership and Involvement Record Sponsored by the Center for Leadership and Involvement The Leadership and Involvement Record is an official document from the University of Wisconsin recording the leadership roles, student org involvement, or group membership students have had on campus. The record

  6. Graphic Designer Student Involvement and Leadership

    E-Print Network [OSTI]

    Subramanian, Venkat

    Graphic Designer Student Involvement and Leadership Position Overview The Graphic Designer standards of the Student Involvement and Leadership brand guardrails · Complete other duties as assigned-Design, and Illustrator · Must have experience creating print and web graphics, flyers, and other promotional materials

  7. Factors Involved in Search Dog Training

    E-Print Network [OSTI]

    Alexander, Michael B.

    2010-07-14T23:59:59.000Z

    involved in training competent search dogs. Obedience training methods, age training was initiated, previous handler canine training experience, and handler perception and emotional attachment to their search dog were examined through a sixty-six question...

  8. COMMUNITY INVOLVEMENT PLAN APRIL 15, 1999.

    SciTech Connect (OSTI)

    GEIGER,K.

    1999-04-15T23:59:59.000Z

    This Community Involvement Plan has been prepared by the Brookhaven National Laboratory's Community Involvement Office with the input of the community, Laboratory employees and representatives of the U.S. Department of Energy. The process to develop the plan began with the formation of a focus group consisting of representatives from: the community at large; special interest groups within the community; the business community; Laboratory retirees; senior and line management from the Laboratory; and the U.S. Department of Energy. The focus group reviewed an initial outline developed by the Office of Community involvement, held in-depth roundtable discussions of community involvement needs, and created a draft plan based on their discussions. A workshop was held to present the draft Community Involvement Plan to a wider audience for their input and insights on how Brookhaven should involve the community in decision making. This workshop was advertised in local newspapers and within the Laboratory. It was attended by community members, special interest group representatives, Laboratory employees and managers, U.S. Department of Energy-Brookhaven Group management, and members of the Laboratory's Community Advisory Council. The results of the workshop discussions are incorporated in this plan.

  9. Environmental science and ecology involve studies

    E-Print Network [OSTI]

    Christensen, Dan

    Environmental science and ecology involve studies of the biosphere, hydro- sphere, and lithosphere in environmental science is conducted on spatial scales varying from a single algal cell to the Earth as a whole's environmental scientists require investigation by an interdisciplinary team, including members from several

  10. Increasing Public Involvement in Structural Biology

    E-Print Network [OSTI]

    Baker, David

    --often referred to as citizen science--provides a means of engaging people's skills, rather than just for the public to get actively involved in structural biology research? Citizen science projects can require areas for citizen science as structural problems both are amenable to human spatial-reasoning skills

  11. Regulation of the genes involved in nitrification.

    SciTech Connect (OSTI)

    Arp, D.J.; Sayavedra-Soto, L.A.

    2003-08-14T23:59:59.000Z

    OAK-B135 This project focuses on the characterization of the regulation of the genes involved in nitrification in the bacterium Nitrosomonas europaea. The key genes in the nitrification pathway, amo and hao, are present in multiple copies in the genome. The promoters for these genes were identified and characterized. It was shown that there were some differences in the transcriptional regulation of the copies of these genes.

  12. Community Involvement Fund | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsNovember 13, 2014 BuildingEnergy EfficiencyPast ProjectsCommunity Involvement

  13. Apolipoprotein gene involved in lipid metabolism

    DOE Patents [OSTI]

    Rubin, Edward (Berkeley, CA); Pennacchio, Len A. (Sebastopol, CA)

    2007-07-03T23:59:59.000Z

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  14. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01T23:59:59.000Z

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  15. Public involvement in radioactive waste management decisions

    SciTech Connect (OSTI)

    NONE

    1994-04-01T23:59:59.000Z

    Current repository siting efforts focus on Yucca Mountain, Nevada, where DOE`s Office of Civilian Radioactive Waste Management (OCRWM) is conducting exploratory studies to determine if the site is suitable. The state of Nevada has resisted these efforts: it has denied permits, brought suit against DOE, and publicly denounced the federal government`s decision to study Yucca Mountain. The state`s opposition reflects public opinion in Nevada, and has considerably slowed DOE`s progress in studying the site. The Yucca Mountain controversy demonstrates the importance of understanding public attitudes and their potential influence as DOE develops a program to manage radioactive waste. The strength and nature of Nevada`s opposition -- its ability to thwart if not outright derail DOE`s activities -- indicate a need to develop alternative methods for making decisions that affect the public. This report analyzes public participation as a key component of this openness, one that provides a means of garnering acceptance of, or reducing public opposition to, DOE`s radioactive waste management activities, including facility siting and transportation. The first section, Public Perceptions: Attitudes, Trust, and Theory, reviews the risk-perception literature to identify how the public perceives the risks associated with radioactivity. DOE and the Public discusses DOE`s low level of credibility among the general public as the product, in part, of the department`s past actions. This section looks at the three components of the radioactive waste management program -- disposal, storage, and transportation -- and the different ways DOE has approached the problem of public confidence in each case. Midwestern Radioactive Waste Management Histories focuses on selected Midwestern facility-siting and transportation activities involving radioactive materials.

  16. A Self-advocacy Program for Students with Disabilities: Adult Outcomes and Advocacy Involvement One to Six Years after Involvement

    E-Print Network [OSTI]

    Roberts, Eric

    2013-03-08T23:59:59.000Z

    attendance was higher than the national average for adults with disabilities. Participants with low incidence disabilities were involved in inclusive employment more often than the national average. A minority status increased the likelihood of involvement...

  17. active user involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    architecture. DBS was implemented on the Nano-Threads Programming Model (NPM) as part of NANOS, a large-scale project involving the development of a runtime...

  18. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    Magistretti PJ: Brain energy metabolism: focus on astrocyte?involved  in  various  energy  metabolism  processes  that cycle for oxidative energy metabolism and for production of 

  19. Microsoft Word - Number of Public Involvement Deliverables _2...

    National Nuclear Security Administration (NNSA)

    numerous (+150) video clips and raw video * Maintain the Public Involvement portion of web-based Environmental Management Information System (includes uploading briefings,...

  20. activity involving yb-1: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  1. adenylyl cyclase involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  2. ahr repressor involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  3. anaemia potential involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  4. antigens predominant involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  5. actinobacillus pleuropneumoniae involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  6. aedes aegypti involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  7. accidental fatalities involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  8. adenosinergic system involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  9. aspergillus nidulans involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  10. aminoguanidine involve reduced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  11. arteriovenous malformations involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  12. alternata involves active: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  13. anterior prefrontal involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  14. adjuvant involved field: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  15. asymptomatic lymphangioma involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  16. alternaria alternata involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  17. antinociception involves endogenous: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  18. apoptosis involving activation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  19. arteriovenous malformation involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  20. accidents involving external: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    25 Next Page Last Page Topic Index 1 Development and use of the ESReDA directory of accident databases involving chemicals Computer Technologies and Information Sciences Websites...

  1. INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis

    SciTech Connect (OSTI)

    Ausin, Israel; Greenberg, Maxim V.C.; Simanshu, Dhirendra K.; Hale, Christopher J.; Vashisht, Ajay A.; Simon, Stacey A.; Lee, Tzuu-fen; Feng, Suhua; Española, Sophia D.; Meyers, Blake C.; Wohlschlegel, James A.; Patel, Dinshaw J.; Jacobsen, Steven E. (UCLA); (MSKCC); (Delaware)

    2012-10-23T23:59:59.000Z

    At least three pathways control maintenance of DNA cytosine methylation in Arabidopsis thaliana. However, the RNA-directed DNA methylation (RdDM) pathway is solely responsible for establishment of this silencing mark. We previously described INVOLVED IN DE NOVO 2 (IDN2) as being an RNA-binding RdDM component that is required for DNA methylation establishment. In this study, we describe the discovery of two partially redundant proteins that are paralogous to IDN2 and that form a stable complex with IDN2 in vivo. Null mutations in both genes, termed IDN2-LIKE 1 and IDN2-LIKE 2 (IDNL1 and IDNL2), result in a phenotype that mirrors, but does not further enhance, the idn2 mutant phenotype. Genetic analysis suggests that this complex acts in a step in the downstream portion of the RdDM pathway. We also have performed structural analysis showing that the IDN2 XS domain adopts an RNA recognition motif (RRM) fold. Finally, genome-wide DNA methylation and expression analysis confirms the placement of the IDN proteins in an RdDM pathway that affects DNA methylation and transcriptional control at many sites in the genome. Results from this study identify and describe two unique components of the RdDM machinery, adding to our understanding of DNA methylation control in the Arabidopsis genome.

  2. LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING

    E-Print Network [OSTI]

    LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING GEOSYTNTHETICS Virginia L. Wilson: Geosynthetics: Lessons Learned from Failures International Geosynthetics Society editors J.P. Giroud, K.L. Soderman and G.P. Raymond November 12, 1998 #12;LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING

  3. Lessons Learned from Failures Involving Geofoam in Roads and Embankments

    E-Print Network [OSTI]

    Horvath, John S.

    Lessons Learned from Failures Involving Geofoam in Roads and Embankments Manhattan College Research July 1999) #12;Lessons Learned from Failures Involving Geofoam in Roads and Embankments Manhattan College Research Report No. CE/GE-99-1 ii This page intentionally left blank. #12;Lessons Learned from

  4. Citizen Involvement in Water Resources Issues in New England

    E-Print Network [OSTI]

    Gold, Art

    was developed and conducted in May of 2005. This survey was based on a template developed in the PacificCitizen Involvement in Water Resources Issues in New England Abstract A survey determined citizen the degree of current citizen involvement in water resources issues in New England, a public opinion survey

  5. Voluntary Associations and Their Involvement in Collaborative Forest Management

    E-Print Network [OSTI]

    Lu, Jiaying

    2012-02-14T23:59:59.000Z

    . This dissertation was aimed at gaining a better understanding of outdoor recreation and environmental voluntary associations and their involvement in collaborative forest management. Five objectives guided this study: (1) assessing the organizational characteristics...

  6. Unsaturated geotechnics applied to geoenvironmental engineering problems involving geosynthetics

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    such as geotextiles and geosynthetic clay liners (GCLs) with particular focus on capillary barriers, liner performanceUnsaturated geotechnics applied to geoenvironmental engineering problems involving geosynthetics Available online 15 February 2013 Keywords: Capillary break Desiccation Flow Geosynthetics Interface shear

  7. A fast enriched FEM for Poisson equations involving interfaces

    E-Print Network [OSTI]

    Huynh, Thanh Le Ngoc

    2008-01-01T23:59:59.000Z

    We develop a fast enriched finite element method for solving Poisson equations involving complex geometry interfaces by using regular Cartesian grids. The presence of interfaces is accounted for by developing suitable jump ...

  8. A Protein Export Pathway Involving Escherichia coli Porins

    E-Print Network [OSTI]

    McIntosh, Lawrence P.

    Structure Article A Protein Export Pathway Involving Escherichia coli Porins Gerd Prehna,1,2 Guijin@byron.biochem.ubc.ca (N.C.J.S.) DOI 10.1016/j.str.2012.04.014 SUMMARY Escherichia coli export the protein Yeb common to all E. coli strains has been reported, the mechanism of export has remained unclear. Herein, we

  9. Formation Mechanism for a Hybrid Supramolecular Network Involving Cooperative Interactions

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Formation Mechanism for a Hybrid Supramolecular Network Involving Cooperative Interactions Manuela of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom; CEA, IRAMIS, SPCSI, Hybrid University, 24-29 St Giles, Oxford, OX1 3LB, United Kingdom 4 Department of Materials, University of Oxford

  10. Nuclear Decommissioning and Organisational Reliability: Involving Subcontractors in Collective Action

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Page 1 Nuclear Decommissioning and Organisational Reliability: Involving Subcontractors to the decommissioning. The use of subcontractors is not new; in the nuclear industry it became widespread in the 1990s reliability is at the heart of the safety of at-risk systems. Many studies have been conducted in the nuclear

  11. Research Article Acetylcholinesterase in intestinal cell differentiation involves

    E-Print Network [OSTI]

    Tian, Weidong

    involved in the terminal differentiation of enterocytes. Butyrate, a short-chain fatty acid produced in the colonic lumen by microbial fermentation, is taken up by cells of the intestinal epithelium, and serves of acetylcholine to choline and acetate. Interestingly, the expression of AChE is not restricted to cholinergic

  12. If the internship is international or involves international travel, the

    E-Print Network [OSTI]

    Hart, Gus

    If the internship is international or involves international travel, the student does not need to complete the IRAMS student internship ap- plication, but should contact the Kennedy Center for internship approval and course registration. Flag will be removed, and students will be able to add their internship

  13. If the internship is international or involves international travel, the

    E-Print Network [OSTI]

    Dahl, David B.

    If the internship is international or involves international travel, the student does not need to complete the IRAMS student internship application, but should contact the Kennedy Center for internship approval and course registration. Flag will be removed, and students will be able to add their internship

  14. ORIGINAL PAPER Expression of genes involved in energy mobilization

    E-Print Network [OSTI]

    Lee Jr., Richard E.

    ORIGINAL PAPER Expression of genes involved in energy mobilization and osmoprotectant synthesis, mobilizing carbohydrate energy reserves to promote synthesis of low-molecular-mass osmoprotectants Department of Entomology, Ohio State University, Columbus, OH 43210, USA e-mail: teets.23@osu.edu Y

  15. Hypoxylon mammatum toxins: possible involvement in canker development on aspen

    E-Print Network [OSTI]

    Boyer, Edmond

    Hypoxylon mammatum toxins: possible involvement in canker development on aspen I. Genetet1 J. Pinon a stem canker on aspen (Populus tremula) and on some poplars of the Taca- hamaca section (Pinon, 1976 inhibited callus formation in wounds on aspen bark. Schipper (1978) and Ster- mer et aL, (1984) confirmed

  16. Mechanism of heterogeneous catalytic reactions involving molecular hydrogen

    SciTech Connect (OSTI)

    Golodets, G.I.

    1987-07-01T23:59:59.000Z

    By means of various physicochemical methods, including kinetics, the mechanism of a series of reactions involving molecular H/sub 2/ (the hydrogenation of carbonyl compounds, nitriles, carbon monoxide, molecular nitrogen, and oxygen) on metallic catalysts of different chemical compositions and degrees of dispersion has been investigated. Some general laws for reactions of this class are formulated.

  17. Argonne National Laboratory has been actively involved in the development

    E-Print Network [OSTI]

    Kemner, Ken

    Argonne National Laboratory has been actively involved in the development of advanced batteries at Argonne and named it the National Battery Test Laboratory (NBTL), for the purpose of conducting in these early days of the battery program, Argonne was internationally respected for its advanced battery work

  18. LESSONS LEARNED FROM AN IMPOUNDMENT SLOPE FAILURE INVOLVING GEOSYNTHETICS

    E-Print Network [OSTI]

    failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment. KEYWORDS: Geosynthetic clay liners, Interface Shear Strength, Waste containment, Strength, Stability to illustrate the importance of (i) properly storing geosynthetic clay liners (GCLs) to reduce the amount

  19. On some arithmetic properties of polynomial expressions involving Stirling numbers

    E-Print Network [OSTI]

    Klazar, Martin

    On some arithmetic properties of polynomial expressions involving Stirling numbers of the second by the grant SEP-CONACYT 37259-E. 1 #12;Abstract Let S(n, k) be the classical Stirling numbers of the second. We give similar but more particular results on the more general Stirling-like numbers T(n, k). 2 #12

  20. DEVELOPMENT AND USE OF A DIRECTORY OF ACCIDENT DATABASES INVOLVING

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    DEVELOPMENT AND USE OF A DIRECTORY OF ACCIDENT DATABASES INVOLVING CHEMICALS J.P.Pineau Institut from end-users of accident data who need validated data for dealing with risk assessment in which Data collection Data analysis, Reliability, Uncertainty, Accident, Hazardous material, Risk analysis

  1. Get Involved with Home Energy Score | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers3.pdf0-45.pdf0 Budget FossilGeothermalGeothermal developersGet Involved with

  2. NEPA-Related Public Involvement | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagement of theTechno-economicOctober 2013NEPA-Related Public Involvement

  3. Get Involved with Home Energy Score | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdf Flash2006-52.pdf0.pdfDepartmentCounsel LawDemonstrationDepartmentGet Involved with

  4. COMPASS Hadron Spectroscopy -- Final states involving neutrals and kaons

    E-Print Network [OSTI]

    Frank Nerling; for the COMPASS collaboration

    2010-09-11T23:59:59.000Z

    The COMPASS experiment at CERN is well designed for light-hadron spectroscopy with emphasis on the detection of new states, in particular the search for $J^{PC}$-exotic states and glueballs. We have collected data with 190 GeV/c charged hadron beams on a liquid hydrogen and nuclear targets in 2008/09. The spectrometer features good coverage by electromagnetic calorimetry and a RICH detector further provides $\\pi$ / $K$ separation, allowing for studying final states involving neutral particles like $\\pi^0$ or $\\eta$ as well as hidden strangeness, respectively. We discuss the status of ongoing analyses with specific focus on diffractively produced $(\\pi^0\\pi^0\\pi)^{-}$ as well as $(K\\bar{K}\\pi)^{-}$ final states.

  5. Personnel involved in nuclear standards development: 1980 directory

    SciTech Connect (OSTI)

    Carr, S.J. (ed.)

    1980-03-01T23:59:59.000Z

    The development of nuclear standards is an active and necessary endeavor that is concerned with the safe, orderly, and economic development of nuclear potential. There are almost 4100 people from the teachnical community who are presently involved either in writing nuclear standards, including codes, or in the management and processing roles necessary for their approval and promulgation. This document identifies the current participation of each individual as member, chairman, cochairman (vice-chairman), or secretary of about 700 standards development committees and groups. The standards committees and groups are identified with the organizations that are responsible for the preparation, review, and maintenance of the standards and that provide support through supervisory committees and headquarters staff. This directory includes four major sections: personnel, employers, committees, and a Key-Word-in-Context (KWIC) Index of committee titles. It can also be used to identify the participation of employers as well as to recognize the contributions of individuals to the often interdisciplinary activity of standards development.

  6. Representation of analysis results involving aleatory and epistemic uncertainty.

    SciTech Connect (OSTI)

    Johnson, Jay Dean (ProStat, Mesa, AZ); Helton, Jon Craig (Arizona State University, Tempe, AZ); Oberkampf, William Louis; Sallaberry, Cedric J.

    2008-08-01T23:59:59.000Z

    Procedures are described for the representation of results in analyses that involve both aleatory uncertainty and epistemic uncertainty, with aleatory uncertainty deriving from an inherent randomness in the behavior of the system under study and epistemic uncertainty deriving from a lack of knowledge about the appropriate values to use for quantities that are assumed to have fixed but poorly known values in the context of a specific study. Aleatory uncertainty is usually represented with probability and leads to cumulative distribution functions (CDFs) or complementary cumulative distribution functions (CCDFs) for analysis results of interest. Several mathematical structures are available for the representation of epistemic uncertainty, including interval analysis, possibility theory, evidence theory and probability theory. In the presence of epistemic uncertainty, there is not a single CDF or CCDF for a given analysis result. Rather, there is a family of CDFs and a corresponding family of CCDFs that derive from epistemic uncertainty and have an uncertainty structure that derives from the particular uncertainty structure (i.e., interval analysis, possibility theory, evidence theory, probability theory) used to represent epistemic uncertainty. Graphical formats for the representation of epistemic uncertainty in families of CDFs and CCDFs are investigated and presented for the indicated characterizations of epistemic uncertainty.

  7. Surface interactions involved in flashover with high density electronegative gases.

    SciTech Connect (OSTI)

    Hodge, Keith Conquest; Warne, Larry Kevin; Jorgenson, Roy Eberhardt; Wallace, Zachariah Red; Lehr, Jane Marie

    2010-01-01T23:59:59.000Z

    This report examines the interactions involved with flashover along a surface in high density electronegative gases. The focus is on fast ionization processes rather than the later time ionic drift or thermalization of the discharge. A kinetic simulation of the gas and surface is used to examine electron multiplication and includes gas collision, excitation and ionization, and attachment processes, gas photoionization and surface photoemission processes, as well as surface attachment. These rates are then used in a 1.5D fluid ionization wave (streamer) model to study streamer propagation with and without the surface in air and in SF6. The 1.5D model therefore includes rates for all these processes. To get a better estimate for the behavior of the radius we have studied radial expansion of the streamer in air and in SF6. The focus of the modeling is on voltage and field level changes (with and without a surface) rather than secondary effects, such as, velocities or changes in discharge path. An experiment has been set up to carry out measurements of threshold voltages, streamer velocities, and other discharge characteristics. This setup includes both electrical and photographic diagnostics (streak and framing cameras). We have observed little change in critical field levels (where avalanche multiplication sets in) in the gas alone versus with the surface. Comparisons between model calculations and experimental measurements are in agreement with this. We have examined streamer sustaining fields (field which maintains ionization wave propagation) in the gas and on the surface. Agreement of the gas levels with available literature is good and agreement between experiment and calculation is good also. Model calculations do not indicate much difference between the gas alone versus the surface levels. Experiments have identified differences in velocity between streamers on the surface and in the gas alone (the surface values being larger).

  8. Governance, participation and avoidance: everyday public involvement in the Scottish NHS 

    E-Print Network [OSTI]

    Stewart, Ellen Anderson

    2012-06-29T23:59:59.000Z

    Public involvement in health services is an area of policy where ostensibly good intentions appear to repeatedly fail in implementation. Since the late 1990s public involvement in the UK NHS has been subject to frequent ...

  9. Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development and Sulfur Metabolism. Involvement of Shewanella oneidensis MR-1 LuxS in Biofilm Development and Sulfur...

  10. Application of Dissolution Dynamic Nuclear Polarization to the Characterization of Reactions Involving Large Molecules

    E-Print Network [OSTI]

    Lee, Youngbok

    2013-03-13T23:59:59.000Z

    aims to extend the applicability of D-DNP into new areas of chemistry, which involve the characterization of interactions and reactions involving large molecules. In a first project, fluorine hyperpolarization is exploited to investigate protein...

  11. The effects of school gardening on parent involvement in elementary schools

    E-Print Network [OSTI]

    Boyer, Roxanne Christina

    2002-01-01T23:59:59.000Z

    to helping with schoolwork at home (Henderson et al. , 1986). Some researchers divide types of involvement according to where it occurs such as in the home?school, or community (NCES, 1997). Others define parent involvement according to how... in parenting, communicating, volunteering, learning at home, decision making, and collaborating with the community (Epstein, 1995). Henderson and others (1986) define parent involvement in terms of the roles that parents have in education such as partners...

  12. Molecular genetic analysis of activation-tagged transcription factors thought to be involved in photomorphogenesis

    SciTech Connect (OSTI)

    Neff, Michael M.

    2011-06-23T23:59:59.000Z

    This is a final report for Department of Energy Grant No. DE-FG02-08ER15927 entitled “Molecular Genetic Analysis of Activation-Tagged Transcription Factors Thought to be Involved in Photomorphogenesis”. Based on our preliminary photobiological and genetic analysis of the sob1-D mutant, we hypothesized that OBP3 is a transcription factor involved in both phytochrome and cryptochrome-mediated signal transduction. In addition, we hypothesized that OBP3 is involved in auxin signaling and root development. Based on our preliminary photobiological and genetic analysis of the sob2-D mutant, we also hypothesized that a related gene, LEP, is involved in hormone signaling and seedling development.

  13. aopex11-1 gene involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  14. antagonist labedipinedilol-a involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  15. aeruginosa w51d involves: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  16. analysis involving tvs-m: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  17. acetobutylicum involving non-coding: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  18. arene di-oxygenases involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEOSYNTHETICS Engineering Websites Summary: failure involving a reinforced geosynthetic clay liner in a sedimentation pond at a waste containment liners to hydrate during on-site...

  19. Customer Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would likeConstitution4Customer-Comments Sign In About | Careers |

  20. Getting Involved

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental AssessmentsGeoffrey

  1. Unravelling aspects of the gas phase chemistry involved in diamond chemical vapour deposition

    E-Print Network [OSTI]

    Bristol, University of

    of thin Ðlms of polycrystalline diamond by chemi- cal vapour deposition (CVD) methods,2h4 since which timeUnravelling aspects of the gas phase chemistry involved in diamond chemical vapour deposition been used to unravel details of the gas phase chemistry involved in diamond chemical vapour deposition

  2. Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast

    E-Print Network [OSTI]

    Wang, Y.Q. "Yeqiao"

    Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast.1080/08920750590883132 Involving Geospatial Information in the Analysis of Land-Cover Change along the Tanzania Coast YEQIAO WANG and the area of woodland interspersed with agriculture increased. This study demonstrates how geospatial

  3. New Developments involving the Stream Health Index for the Puget Sound Lowland

    E-Print Network [OSTI]

    Washington at Seattle, University of

    New Developments involving the Stream Health Index for the Puget Sound Lowland Grace Chiu Peter and ecological sciences. #12;#12;Full title: New Developments involving the Stream Health Index for the Puget;SUMMARY Since the introduction of the stream health index for the Puget Sound Lowland (SHIPSL) (Chiu

  4. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

    E-Print Network [OSTI]

    Quirk, Gregory J.

    experiments designed to bridge human and rodent models of emotion regulation. Addresses 1 Department of prefrontal involvement of emotion regula- tion using rat and human models, and suggest future experimentsPrefrontal involvement in the regulation of emotion: convergence of rat and human studies Gregory J

  5. ORIGINAL PAPER On the Role of the Difference in Surface Tensions Involved

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER On the Role of the Difference in Surface Tensions Involved in the Allosteric was to develop the relationship between membrane surface tension, and the allosteric balance in a difference in surface tensions that is involved in the creation of a reservoir of intracellular vesicles

  6. What is the effect of 4-H involvement on levels of empathy, self-esteem, community involvement and positive view of the future on urban youth?

    E-Print Network [OSTI]

    Bonnett, Erika Dawn

    2007-04-25T23:59:59.000Z

    , self-esteem, positive view of the future, and community involvement. The study utilized a quantitative research model in which a survey was taken of youth presiding in urban areas in the state of Texas. Descriptive statistics were used to report subject...

  7. Dosimetric and Clinical Outcomes of Involved-Field Intensity-Modulated Radiotherapy After Chemotherapy for Early-Stage Hodgkin's Lymphoma With Mediastinal Involvement

    SciTech Connect (OSTI)

    Lu Ningning [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Li Yexiong, E-mail: yexiong@yahoo.com [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Wu Runye; Zhang Ximei; Wang Weihu; Jin Jing; Song Yongwen; Fang Hui; Ren Hua; Wang Shulian; Liu Yueping; Liu Xinfan; Chen Bo; Dai Jianrong; Yu Zihao [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)

    2012-09-01T23:59:59.000Z

    Purpose: To evaluate the dosimetric and clinical outcomes of involved-field intensity-modulated radiotherapy (IF-IMRT) for patients with early-stage Hodgkin's lymphoma (HL) with mediastinal involvement. Methods and Materials: Fifty-two patients with early-stage HL that involved the mediastinum were reviewed. Eight patients had Stage I disease, and 44 patients had Stage II disease. Twenty-three patients (44%) presented with a bulky mediastinum, whereas 42 patients (81%) had involvement of both the mediastinum and either cervical or axillary nodes. All patients received combination chemotherapy followed by IF-IMRT. The prescribed radiation dose was 30-40 Gy. The dose-volume histograms of the target volume and critical normal structures were evaluated. Results: The median mean dose to the primary involved regions (planning target volume, PTV1) and boost area (PTV2) was 37.5 Gy and 42.1 Gy, respectively. Only 0.4% and 1.3% of the PTV1 and 0.1% and 0.5% of the PTV2 received less than 90% and 95% of the prescribed dose, indicating excellent PTV coverage. The median mean lung dose and V20 to the lungs were 13.8 Gy and 25.9%, respectively. The 3-year overall survival, local control, and progression-free survival rates were 100%, 97.9%, and 96%, respectively. No Grade 4 or 5 acute or late toxicities were reported. Conclusions: Despite the large target volume, IF-IMRT gave excellent dose coverage and a favorable prognosis, with mild toxicity in patients with early-stage mediastinal HL.

  8. Ranacyclins, a New Family of Short Cyclic Antimicrobial Peptides: Biological Function, Mode of Action, and Parameters Involved in Target Specificity,,@

    E-Print Network [OSTI]

    Pompeu Fabra, Universitat

    of Action, and Parameters Involved in Target Specificity,,@ M. Luisa Mangoni, Niv Papo,§ Giuseppina Mignogna

  9. Undergraduate business and management students’ experiences of being involved in assessment 

    E-Print Network [OSTI]

    Tai, Chunming

    2012-11-29T23:59:59.000Z

    This study aimed to explore university undergraduates’ experiences of student involvement in assessment (SIA). Based on Biggs’ 3P model of student learning, this study focused on students’ experiences prior to SIA, during ...

  10. The role of involvement and commitment in explaining intention to engage in birding trips

    E-Print Network [OSTI]

    Kim, Seong-Seop

    1996-01-01T23:59:59.000Z

    -psychological involvement measures, and measures of commitment; (c) to ascertain how well Laurent and Kapferer's (1985) scale, Zaichkowsky's (1985) scale, a set of behavioral measures, and commitment nimures explain intention to go on birding trips; (4) to conceptualize...

  11. A study of parental involvement and school climate: Perspective from the middle school

    E-Print Network [OSTI]

    Dixon, Shantina Rayford

    2009-05-15T23:59:59.000Z

    This study examines school level differences on different dimensions of teacherrated parent involvement and school climate while adjusting for age, gender, ethnicity, how certified, and number of years teaching. Two hundred twenty-four elementary...

  12. School-Based Family Involvement: Patterns and Predictors in the NLTS2

    E-Print Network [OSTI]

    Frew, Leigh Ann

    2012-10-19T23:59:59.000Z

    This investigation used data from the National Longitudinal Transition Study 2 (NLTS2) to investigate patterns among student, family, and school characteristics, school outreach programs, and school-based family involvement for families of 5...

  13. Examination of offsite radiological emergency protective measures for nuclear reactor accidents involving core melt

    E-Print Network [OSTI]

    Aldrich, David C.

    1979-01-01T23:59:59.000Z

    Evacuation, sheltering followed by population relocation, and iodine prophylaxis are evaluated as offsite public protective measures in response to nuclear reactor accidents involving core-melt. Evaluations were conducted ...

  14. Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir

    E-Print Network [OSTI]

    Nucleotide diversity and neutrality testing in genes involved in adaptation in Douglas-fir B. Pande-Oregon region, and 684 SNPs were identified in total. We report the estimation of nucleotide diversity and tests

  15. Use of associated polynomials for division involving polynomials over arbitrary fields

    E-Print Network [OSTI]

    Jones, James Edgar

    1968-01-01T23:59:59.000Z

    USE OF ASSOCIATED POLYNOMIALS FOR DIVISION INVOLVING POLYNOMIALS OVER ARBITRARY FIELDS A Thesis by JAMES EDGAR JOiVES Submitted to the Graduate College of the Texas A&M University in partiai fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1968 Major Subject: MATHEJRTICS USE OF ASSOCIATED POLYNOMIALS FOR DIVISION INVOLVING POLYNOMIALS OVER ARBITRARY FIELDS A Thesis by JAMES EDGAR JONES Approved as to style and content by (Chairman of Committee) (Head...

  16. Reform of the EIA process in Indonesia: improving the role of public involvement

    SciTech Connect (OSTI)

    Purnama, Dadang

    2003-07-01T23:59:59.000Z

    The implementation of Environmental Impact Assessment (EIA) as a planning tool has been utilised for a relatively long time in Indonesia. It was introduced formally through the Act No. 4/1982. Supporting regulation was established in 1986 when Government Regulation No. 29 was enacted. After developing the EIA system for 14 years, Indonesia finally recognized the importance of emphasizing public involvement in the EIA guidelines of 2000. EIA in the previous Indonesian regulations, i.e. Regulation No. 29/1986 and No. 51/1993, did not have provisions for direct public involvement. The Indonesian Government Regulation No. 27/1999 is currently accommodating the above issue. Guidelines for public announcement and public involvement have been introduced in a decree issued by the Head of Indonesia's Environmental Impact Management Agency No. KepDal 08/2000. This was officially enacted on 7 November 2000 in response to the demand for more public involvement, an issue that was ambiguous in the previous legislation. This paper discusses: the implementation of the new guidelines; what has been achieved; and the challenges during implementation. While the paper focuses its review on the Indonesian EIA system, Indonesia's experience is relevant to many other developing countries that are starting to adopt public involvement in their decision-making processes.

  17. The Community Environmental Monitoring Program: Reducing Public Perception of Risk through Stakeholder Involvement

    SciTech Connect (OSTI)

    William T. Hartwell

    2007-05-21T23:59:59.000Z

    The Community Environmental Monitoring Program (CEMP) has promoted stakeholder involvement, awareness, and understanding of radiological surveillance in communities surrounding the Nevada Test Site (NTS) since 1981. It involves stakeholders in the operation, data collection, and dissemination of information obtained from a network of 29 stations across a wide area of Nevada, Utah and California. It is sponsored by the U.S. Department of Energy, National Nuclear Security Administration’s Nevada Site Office (NNSA/NSO) and administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. Integration of a near real-time communications system, a public web site, training workshops for involved stakeholders, and educational programs all help to alleviate public perception of risk of health effects from past activities conducted at the NTS.

  18. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect (OSTI)

    United States. Bonneville Power Administration.

    1994-01-01T23:59:59.000Z

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  19. Staying Competitive in the 90's: How to Make Public Involvement Work for Your Energy Project

    E-Print Network [OSTI]

    Loveless, K. W.

    STAYING COMPETITIVE IN THE 90'S: HOW TO MAKE PUBLIC INVOL VEMENT WORK FOR YOUR ENERGY PROJECT Kat11Y Wood LOVl;!cSS, Prcsidl;l1t, Loveless EnLerprises, Inc., Salt Lake City, Utah ABSTRACT Gone are the days when energy companies could develop... in Washington, D. c., and Denver. She has been analyzing, planning, conducting public involvement events for more than 2 decades. For a free copy of more public involvement techniques call 801-363-1807 or write: 267 E. North Sandrun Rd.,Salt Lake City, Utah...

  20. Study Finds that Children with Autism and Gastrointestinal Symptoms Have Altered Expression of Genes Involved in Digestion

    E-Print Network [OSTI]

    Salzman, Daniel

    of Genes Involved in Digestion These changes may also affect the mix of bacteria present in the digestive disturbances have altered expression of genes involved in digestion. These variations may contribute to changes

  1. A study to examine community involvement in major U.S.military base closures and realignments from 1988 to 2001

    E-Print Network [OSTI]

    Yahn, Nancy Stiles

    2005-11-01T23:59:59.000Z

    This study examines community involvement in major U.S. military base closures and realignments from 1988 to 2001. There were four waves of base closures during this time. They were in 1988, 1991, 1993, and 1995. Community involvement became...

  2. RASRAFMEK-dependent oxidative cell death involving voltage-dependent anion channels

    E-Print Network [OSTI]

    Stockwell, Brent R.

    LETTERS RAS­RAF­MEK-dependent oxidative cell death involving voltage-dependent anion channels J. Fridman1 , Adam J. Wolpaw1 , Inese Smukste1 , John M. Peltier3 , J. Jay Boniface3 , Richard Smith that discriminate between the genetic makeup of normal cells and tumour cells are valuable for treating and under

  3. Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons

    E-Print Network [OSTI]

    Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons for wing morphometry, 12 for cuticular hydrocarbons and five for venom components. We detected 50 QTL / cuticular hydrocarbons / venom 1. INTRODUCTION The first genetic map built from RAPD markers (Hunt and Page

  4. Adaptive Density Estimation in the Pile-up Model Involving Measurement Errors

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Adaptive Density Estimation in the Pile-up Model Involving Measurement Errors Fabienne Comte, Tabea of nonparametric density estimation in the pile-up model. Adaptive nonparametric estimators are proposed for the pile-up model in its simple form as well as in the case of additional measurement errors. Furthermore

  5. A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis

    E-Print Network [OSTI]

    Thomas, David D.

    ) carboxylases involved in fatty acid metabolism and pyruvate carboxylase in gluco- neogenesis [5]. Biotin] and alanine to afford (8S)-8-amino-7-oxononanoic acid 2, whose more common trivial name is 7-keto-8-aminopelargonic acid (KAPA) (Fig. 1) [9,10]. In the second step, KAPA 2 is transaminated to (7R,8S)-7

  6. CLOUD CHAMBER: A PERFORMANCE INVOLVING REAL TIME TWO-WAY INTERACTION BETWEEN SUBATOMIC RADIOACTIVE

    E-Print Network [OSTI]

    Miranda, Eduardo Reck

    " by the radiation-generated ion patterns in the glass chamber. If John plays in one way the ion particlesCLOUD CHAMBER: A PERFORMANCE INVOLVING REAL TIME TWO-WAY INTERACTION BETWEEN SUBATOMIC RADIOACTIVE, Harwell, Oxford, UK ABSTRACT ,,Cloud Chamber is a live performance created by composer Alexis Kirke

  7. Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene Receptor

    E-Print Network [OSTI]

    Klee, Harry J.

    Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene ethylene's role in plant response to virulent and avirulent strains of Xanthomonas campestris pv overexpressing a wild-type NR cDNA were infected with virulent X. campestris pv. vesicatoria. Like the Nr mutant

  8. Guidance for Preparing Research Proposals Involving Diagnostic Use of Ionizing Radiation in Human Use Research

    E-Print Network [OSTI]

    Kay, Mark A.

    Guidance for Preparing Research Proposals Involving Diagnostic Use of Ionizing Radiation in Human Use Research Introduction This guidance has been prepared by the Clinical Radiation Safety Committee of ionizing radiation. CRSCo serves under California Department of Health Services regulations and Nuclear

  9. On the Cover: One route to harvesting the energy of the sun involves learning to mimic

    E-Print Network [OSTI]

    Wu, Zhigang

    #12;On the Cover: One route to harvesting the energy of the sun involves learning to mimic natural the chlorophylls, which play a central role in capturing light and using its energy for photosynthesis in green, and atmospheric carbon dioxide. #12;BASIC RESEARCH NEEDS FOR SOLAR ENERGY UTILIZATION Report on the Basic Energy

  10. DEA Efficiency Analysis Involving Multiple Production Processes with an Application to

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    with which input resources are allocated to the subunits. It introduces a simple model for efficientlyDEA Efficiency Analysis Involving Multiple Production Processes with an Application to Urban Mass in the Department of Information Systems and Technology within in the College of Business Administration

  11. Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by FeO

    E-Print Network [OSTI]

    Metz, Ricardo B.

    Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by Fe.1063/1.1448489 I. INTRODUCTION The direct oxidation of methane to an easily transport- able liquid such as methanol process and as the simplest model for alkane oxidation.1,2 Although no direct, efficient methane­methanol

  12. Distributional properties of Euclidean distances in wireless networks involving road systems

    E-Print Network [OSTI]

    Schmidt, Volker

    1 Distributional properties of Euclidean distances in wireless networks involving road systems of large wireless networks. The network geometry is modelled by random geometric graphs, and the locations are closely related with the interference geometry and, consequently, the performance of wireless networks

  13. Ohio State Colleges/Units Involved College of Arts and Sciences

    E-Print Network [OSTI]

    Nahar, Sultana Nurun

    Affairs Community Partners Involved Indian Universities: Aligarh Muslim University Delhi University Saudi Arabian universities Obama-Singh 21st Century Knowledge Initiative Award Project: STEM Education members. For the project, the OSU partnership with Aligarh Muslim University (AMU) in India received one

  14. Director, MIT Libraries A great benefit of involvement in the planning for MIT's 150th

    E-Print Network [OSTI]

    Reuter, Martin

    Director, MIT Libraries A great benefit of involvement in the planning for MIT's 150th anniversary, and then sustain, MIT's novel and visionary educational philosophy of "Mens et Manus." MIT's future- oriented a university library system that is, like MIT itself, inventive and forward looking. From an early expectation

  15. DNA Identification of Mountain Lions Involved in Livestock Predation and Public Safety Incidents and Investigations

    E-Print Network [OSTI]

    Ernest, Holly

    1 DNA Identification of Mountain Lions Involved in Livestock Predation and Public Safety Incidents concolor, bobcat, forensic, genetics, DNA techniques, noninvasive sampling, fecal DNA, prey swab DNA ABSTRACT Using three case studies, we demonstrated the utility of techniques to analyze DNA from trace

  16. Involvement of the Czech environmental movements in the European game: which impact on their repertory of

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    73 Involvement of the Czech environmental movements in the European game: which impact observe that each country is embedded in its own history. Communism for example, has been experienced. In my own case, these issues have been analysed using Czech environmental actors. #12;Social Movement

  17. PROJECT GOALS This project involved the development of the first Carbon

    E-Print Network [OSTI]

    emissions, which will in turn allow prioritisation of actions to reduce the ANU carbon footprint. TYPEPROJECT GOALS This project involved the development of the first Carbon Emissions Inventory report and master Excel spreadsheet Figure 1: ANU Carbon Emission by Category (t CO2e) DESCRIPTION

  18. MINIMIZERS OF COST-FUNCTIONS INVOLVING NONSMOOTH DATA-FIDELITY TERMS. APPLICATION TO THE

    E-Print Network [OSTI]

    Nikolova, Mila

    MINIMIZERS OF COST-FUNCTIONS INVOLVING NONSMOOTH DATA-FIDELITY TERMS. APPLICATION TO THE PROCESSING cost- function F(x, y) = (x, y) + (x), where is a data-fidelity term, is a smooth regularization term construct a cost-function allowing aberrant data (outliers) to be detected and to be selectively smoothed

  19. PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

    E-Print Network [OSTI]

    Peng, Qianqian; Zhao, Jinghua; Xue, Fuzhong

    2010-01-26T23:59:59.000Z

    2005, 77:567-581. 23. Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, Helm-van Mil van der AHM, Toes REM, Huizinga TW, Klareskog L, Alfredsson L, et al: Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking...

  20. RISK ASSESSMENT OF A FIRE INVOLVING COMBUSTIBLE MATERIALS IN A WAREHOUSE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    in "4. International seminar on fire and explosion hazards, Londonderry : Ireland (2003)" #12;SeRISK ASSESSMENT OF A FIRE INVOLVING COMBUSTIBLE MATERIALS IN A WAREHOUSE Wang, H.Y. ', Russo, P modeling into a rack fire in warehouse, and an identifi- cation of the visible flame shape when a fire

  1. Cytosolic High Km 5 -Nucleotidase and 5 (3 )-Deoxyribonucleotidase in Substrate Cycles Involved in Nucleotide Metabolism*

    E-Print Network [OSTI]

    Bianchi, Vera

    in Nucleotide Metabolism* Received for publication, August 21, 2000, and in revised form, November 14, 2000 that the hkm-NT is not involved in the regulation of deoxyribo- nucleotide pools but affects IMP and GTP pools. dNT-1, instead, appears to be the catabolic arm of substrate cycles regulating pyrimidine nucleotide

  2. Statistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter

    E-Print Network [OSTI]

    Washington at Seattle, University of

    of the Workshop was to initiate a statistical research program relevant to setting air quality standardsStatistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter Lawrence H. Cox NRCSET e c h n i c a l R e p o r t S e r i e s NRCSE-TRS No. 041 January 10, 2000 The NRCSEwas

  3. Emergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    -492-6025. For Non-Emergency Fire and Natural Gas Questions call the CU Fire Marshall @ 303-492-4042. AdditionalEmergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas leaks, the following actions should be taken: 1) Life Safety First 2) Evacuate Immediate Area 3

  4. Differing Professional Opinions Manual for Technical Issues Involving Environment, Safety, and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-11-16T23:59:59.000Z

    This Manual establishes a differing professional opinion (DPO) policy to a Department of Energy (DOE) Differing Professional Opinion (DPO) Process to encourage and facilitate dialogue and resolution on DPOs from employees for technical issues involving environment, safety, and health. Does not cancel other directives. Canceled by DOE O 442.2.

  5. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01T23:59:59.000Z

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  6. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01T23:59:59.000Z

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county`s future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  7. Utility/Industry Partnerships Involving Distributed Generation Technologies in Evolving Electricity Markets

    E-Print Network [OSTI]

    Rastler, D. M.

    Wires Manage Wires defer capital Optimize Energy Services Not Utility Business Not Utility Business New Business Opportunities DISTRIBUTED GENERATION Distributed generation includes small gas turbines, micro-turbines, fuel cells, storage...UTILITYIINDUSTRY PARTNERSHIPS INVOLVING DISTRIBUTED GENERATION TECHNOLOGIES IN EVOLVING ELECTRICITY MARKETS Daniel M. Rastler Manager, Fuel Cells and Distributed Generation Electric Power Research Institute Palo Alto, California ABSTRACT...

  8. Weather encapsulates the state of the atmosphere, primarily involving the component which affects

    E-Print Network [OSTI]

    Allan, Richard P.

    1 #12;2 Weather encapsulates the state of the atmosphere, primarily involving the component which and Telegraph readers tend to use oF #12;5 The human body has an energy balance just like the Earth (solar range in larger on still, clear days, when solar heating is strong at the surface and is not offset

  9. Eight interesting identities involving the exponential function, derivatives, and Stirling numbers of the second kind

    E-Print Network [OSTI]

    Qi, Feng

    2012-01-01T23:59:59.000Z

    In the paper, the author establishes some identities which show that the functions $\\frac1{(1-e^{\\pm t})^k}$ and the derivatives $\\bigl(\\frac1{e^{\\pm t}-1}\\bigr)^{(i)}$ can be expressed each other by linear combinations with coefficients involving the combinatorial numbers and the Stirling numbers of the second kind, where $t\

  10. Thermal Sciences The thermal sciences area involves the study of energy conversion and transmission, power

    E-Print Network [OSTI]

    New Hampshire, University of

    Thermal Sciences The thermal sciences area involves the study of energy conversion and transmission, power generation, the flow of liquids and gases, and the transfer of thermal energy (heat) by means in virtually all energy conversion devices and systems. One may think of the jet engine as a mechanical device

  11. Second-order integrals of motion for spin involving systems in $E_2$

    E-Print Network [OSTI]

    Ismet Yurdusen

    2014-07-16T23:59:59.000Z

    In two-dimensional Euclidean plane, existence of second-order integrals of motion is investigated for integrable Hamiltonian systems involving spin (\\emph{e.g.,} those systems describing interaction between two particles with spin 0 and spin 1/2) and it has been shown that no nontrivial second-order integrals of motion exist for such systems.

  12. Predicting Pelvic Lymph Node Involvement in Current-Era Prostate Cancer

    SciTech Connect (OSTI)

    Rahman, Sophia, E-mail: sophs1578@yahoo.com [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States); Cosmatos, Harry [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States); Dave, Giatri [Kaiser Permanente Medical Center, Department of Radiation Oncology, Fresno, CA (United States); Williams, Stephen [Kaiser Permanente Medical Center, Department of Urology, Los Angeles, CA (United States); Tome, Michael [Kaiser Permanente Medical Center, Department of Radiation Oncology, Los Angeles, CA (United States)

    2012-02-01T23:59:59.000Z

    Purpose: The Roach formula [2/3 Multiplication-Sign prostate-specific antigen + (Gleason score - 6) Multiplication-Sign 10], derived in 1993 during the early prostate specific antigen (PSA) screening era, has been used to predict the risk of pelvic lymph node involvement in patients with prostate cancer. In the current era of widespread PSA screening with a shift to earlier disease stages, there is evidence to suggest that the Roach score overestimates risk of nodal metastasis. This study retrospectively reviews the validity of this formula as a prediction tool. Methods and Materials: We conducted a retrospective institutional review including men with clinical T1c-T3 prostate cancer, with baseline PSA levels and biopsy-obtained Gleason scores who underwent radical prostatectomy with pelvic node dissection from 2001 through 2009 (N = 1,022). The predicted risk of nodal involvement was calculated for each patient using the Roach formula and then compared with actual rates following surgery. Results: The study included 1,022 patients; 99.6% had clinical T1c/T2 disease, with a mean of 10.3 lymph nodes surgically evaluated. Overall, 42 patients (4.1%) had nodal metastasis. For every range of scores, the Roach formula overestimates the risk of nodal involvement. Observed nodal positivity was 1%, 6.3%, 10%, 15.2%, and 16.7% for Roach scores {<=}10%, >10%-20%, >20%-30%, >30%-40%, and >40%, respectively. The Roach score overestimates the risk by approximately 4.5-fold in patients with scores {<=}10%, by 2.5-fold for all scores between 10% and 40%, and by 4-fold for scores >40%. Conclusion: The Roach formula overpredicts the risk of pelvic nodal involvement in current-era prostate cancer patients undergoing regular PSA screening and with mainly T1c/T2 disease. Contemporary patients are much less likely to have nodal involvement for a given PSA and Gleason score.

  13. Public involvement in integrated resource planning: A study of demand-side management collaboratives

    SciTech Connect (OSTI)

    Raab, J. (Raab (J.), Boston, MA (United States)); Schweitzer, M. (Oak Ridge National Lab., TN (United States))

    1992-02-01T23:59:59.000Z

    Many utilities and nonutility parties (NUPs) across the country have tried a new approach to reaching agreement on Demand-Side Management (DSM) program design and policy issues. Through this, which is called the DSM collaborative process, parties who have often been adversaries in the past attempt to reach consensus rather than using traditional litigation to resolve differences. We examined nine cases of DSM collaboration involving 24 utilities and approximately 50 NUPs in 10 states. This is the first comprehensive, in-depth review and assessment of collaboratives and it allows conclusions to be drawn about the collaborative process and the factors that contribute to successful efforts of this type. Collaboratives are described in terms of four major contextual and organizational characteristics: regulatory and legal history, parties involved and parties excluded, collaborative scope, and the collaborative process itself.

  14. Spatial arrangement of trail markers and visitor involvement on a self-guided interpretive trail 

    E-Print Network [OSTI]

    Marcy, Julie Benedict

    1982-01-01T23:59:59.000Z

    be presented by asking "what constitutes an effective SGT in terms of visitor involvement with t'ne trail, leaflet suggestions, and the spacing of stakes or markers on the trail?" An effecrive program or technique is one which achieves its desired... concluded with open-ended questions on suggested improvements for the trail and leaflet. Sontag (27) states rhat there are three main ccmponents of t. rail evaluation: personal objeccive evaluation, observing visitor reaction, and questionnaires...

  15. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF

    SciTech Connect (OSTI)

    Li, Feifei; Jiang, Yinan [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China); Zheng, Qiping [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States)] [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States); Yang, Xiaoming [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China)] [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China); Wang, Siying, E-mail: sywang@ahmu.edu.cn [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)

    2011-01-07T23:59:59.000Z

    Research highlights: {yields} TEC is rapidly tyrosine-phosphorylated and activated by HGF-stimulation in vivo or after partial hepatectomy in mice. {yields} TEC enhances the activity of Elk and serum response element (SRE) in HGF signaling pathway in hepatocyte. {yields} TEC promotes hepatocyte proliferation through the Erk-MAPK pathway. -- Abstract: Background/aims: TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore which signaling pathway TEC is involved in, and how TEC is activated in hepatocyte after hepatectomy and hepatocyte growth factor (HGF) stimulation. Methods: We performed immunoprecipitation (IP) and immunoblotting (IB) to examine TEC tyrosine phosphorylation after partial hepatectomy in mice and HGF stimulation in WB F-344 hepatic cells. The TEC kinase activity was determined by in vitro kinase assay. Reporter gene assay, antisense oligonucleotide and TEC dominant negative mutant (TEC{sup KM}) were used to examine the possible signaling pathways in which TEC is involved. The cell proliferation rate was evaluated by {sup 3}H-TdR incorporation. Results: TEC phosphorylation and kinase activity were increased in 1 h after hepatectomy or HGF treatment. TEC enhanced the activity of Elk and serum response element (SRE). Inhibition of MEK1 suppressed TEC phosphorylation. Blocking TEC activity dramatically decreased the activation of Erk. Reduced TEC kinase activity also suppressed the proliferation of WB F-344 cells. These results suggest TEC is involved in the Ras-MAPK pathway and acts between MEK1 and Erk. Conclusions: TEC promotes hepatocyte proliferation and regeneration and is involved in HGF-induced Erk signaling pathway.

  16. Temperature of aircraft cargo flame exposure during accidents involving fuel spills

    SciTech Connect (OSTI)

    Mansfield, J.A.

    1993-01-01T23:59:59.000Z

    This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

  17. Effects of Parent Expectations and Involvement on the School Readiness of Children in Head Start

    E-Print Network [OSTI]

    Cook, Krystal Tisha'

    2010-10-12T23:59:59.000Z

    EFFECTS OF PARENT EXPECTATIONS AND INVOLVEMENT ON THE SCHOOL READINESS OF CHILDREN IN HEAD START A Dissertation by KRYSTAL TISHA? COOK Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of children enrolled in Head Start. The study examined how these iv parent variables were related to children?s school readiness, and differences between ethnic groups, gender groups, and level of risk. The study tested a model whereby the effect...

  18. Involvement of HIF-2?-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Zhao, Yue; Xu, Wenchao; Luo, Fei; Wang, Bairu; Li, Yuan; Pang, Ying; Liu, Qizhan, E-mail: drqzliu@hotmail.com

    2013-10-15T23:59:59.000Z

    Arsenic is a well established human carcinogen that causes diseases of the lung. Some studies have suggested a link between inflammation and lung cancer; however, it is unknown if arsenite-induced inflammation causally contributes to arsenite-caused malignant transformation of cells. In this study, we investigated the molecular mechanisms underlying inflammation during neoplastic transformation induced in human bronchial epithelial (HBE) cells by chronic exposure to arsenite. The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1? (IL-1?). The data also indicated that HIF-2? was involved in arsenite-induced inflammation. Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells. Thus, these experiments show that HIF-2? mediates arsenite-induced inflammation and that such inflammation is involved in arsenite-induced malignant transformation of HBE cells. The results provide a link between the inflammatory response and the acquisition of a malignant transformed phenotype by cells chronically exposed to arsenite and thus establish a previously unknown mechanism for arsenite-induced carcinogenesis. - Highlights: • Arsenite induces inflammation. • Arsenite-induced the increases of IL-6 and IL-8 via HIF-2?. • Inflammation is involved in arsenite-induced carcinogenesis.

  19. A review of two recent occurrences at the Advanced Test Reactor involving subcontractor activities

    SciTech Connect (OSTI)

    Dahlke, H.J.; Jensen, N.C.; Vail, J.A.

    1997-11-01T23:59:59.000Z

    This report documents the results of a brief, unofficial investigation into two incidents at the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Test Reactor (ATR) facility, reported on October 25 and 31, 1997. The first event was an unanticipated breach of confinement. The second involved reactor operation with an inoperable seismic scram subsystem, violating the reactor`s Technical Specifications. These two incidents have been found to be unrelated. A third event that occurred on December 16, 1996, is also discussed because of its similarities to the first event listed above. Both of these incidents were unanticipated breaches of confinement, and both involved the work of construction subcontractor personnel. The cause for the subcontractor related occurrences is a work control process that fails to effectively interface with LMITCO management. ATR Construction Project managers work sufficient close with construction subcontractor personnel to understand planned day-to-day activities. They also have sufficient training and understanding of reactor operations to ensure adherence to applicable administrative requirements. However, they may not be sufficiently involved in the work authorization and control process to bridge an apparent communications gap between subcontractor employees and Facility Operations/functional support personnel for work inside the reactor facility. The cause for the inoperable seismic scram switch (resulting from a disconnected lead) is still under investigation. It does not appear to be subcontractor related.

  20. The Function and Genetic Interactions of Zebrafish atoh1 and sox2: Genes Involved in Hair Cell Development and Regeneration

    E-Print Network [OSTI]

    Millimaki, Bonny Butler

    2010-10-12T23:59:59.000Z

    THE FUNCTION AND GENETIC INTERACTIONS OF ZEBRAFISH atoh1 AND sox2: GENES INVOLVED IN HAIR CEL DEVELOPMENT AND REGENERATION A Disertation by BONY BUTLER MILIMAKI Submited to the Ofice of Graduate Studies of Texas A... Involved in Hair Cel Development and Regeneration. Copyright 2010 Bonny Butler Milimaki THE FUNCTION AND GENETIC INTERACTIONS OF ZEBRAFISH atoh1 AND sox2: GENES INVOLVED IN HAIR CEL DEVELOPMENT AND REGENERATION A Disertation by BONY...

  1. THE RELATIONSHIP BETWEEN HIGH INVOLVEMENT WORK SYSTEMS, SUPERVISORY SUPPORT, AND ORGANIZATIONAL EFFECTIVENESS: THE ROLE OF EMPLOYEE EXPERIENCES AT WORK

    E-Print Network [OSTI]

    Wadhwa, Preeti

    2012-08-31T23:59:59.000Z

    This study adopts a multilevel, multiple stakeholder perspective to examine the impact of high involvement work systems (HIWS) and supervisory support on organizational effectiveness. Organizational effectiveness is measured ...

  2. Involvement of purinergic system in inflammation and toxicity induced by copper in zebrafish larvae

    SciTech Connect (OSTI)

    Leite, Carlos Eduardo, E-mail: carlos.leite@pucrs.br [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, CEP 90035-003 (Brazil); Maboni, Lucas de Oliveira [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Cruz, Fernanda Fernandes [Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Farmácia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Rosemberg, Denis Broock [Programa de Pós-graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, CEP 89809-000 (Brazil); and others

    2013-11-01T23:59:59.000Z

    The use of zebrafish (Danio rerio) is increasing as an intermediate preclinical model, to prioritize drug candidates for mammalian testing. As the immune system of the zebrafish is quite similar to that of mammals, models of inflammation are being developed for the screening of new drugs. The characterization of these models is crucial for studies that seek for mechanisms of action and specific pharmacological targets. It is well known that copper is a metal that induces damage and cell migration to hair cells of lateral line of zebrafish. Extracellular nucleotides/nucleosides, as ATP and adenosine (ADO), act as endogenous signaling molecules during tissue damage by exerting effects on inflammatory and immune responses. The present study aimed to characterize the inflammatory status, and to investigate the involvement of the purinergic system in copper-induced inflammation in zebrafish larvae. Fishes of 7 days post-fertilization were exposed to 10 ?M of copper for a period of 24 h. The grade of oxidative stress, inflammatory status, copper uptake, the activity and the gene expression of the enzymes responsible for controlling the levels of nucleotides and adenosine were evaluated. Due to the copper accumulation in zebrafish larvae tissues, the damage and oxidative stress were exacerbated over time, resulting in an inflammatory process involving IL-1?, TNF-?, COX-2 and PGE{sub 2}. Within the purinergic system, the mechanisms that control the ADO levels were the most involved, mainly the reactions performed by the isoenzyme ADA 2. In conclusion, our data shed new lights on the mechanisms related to copper-induced inflammation in zebrafish larvae. - Graphical abstract: This scheme provides a chronological proposition for the biochemical events induced by copper in zebrafish larvae. The dashed line shows the absorption of copper over the exposure time. After 1 h of exposure to copper, the release of PGE{sub 2} occurs, followed by an increase of MPO (as a consequence of neutrophil migration), increased expression of genes involved in inflammatory events (IL-1? and TNF-?) and, reduction of the anti-inflammatory cytokine IL-10 at 4 h. At 24 h, the copper concentration is found highly increased, what is coincident with oxidative stress. Regarding the purinergic system, it is possible to observe an inhibition of ecto-5?-NT and ADA, with the consequent increase of AMP and ADA, respectively, at 24 h. The expression of enzyme-related genes shows a decrease in the expression of ecto-5?-NT and variable expressions of ADA subfamily enzymes. - Highlights: • Copper led to increased oxidative stress, and decreased the antioxidants' defenses. • Copper induced time-related changes of IL-1?, TNF-?, IL-10 and PGE{sub 2} levels. • ADA activity controls the levels of adenosine in copper-induced inflammation. • ADA 2 is the main ADA subfamily involved. • The purinergic system seems to be involved in the resolution of inflammation.

  3. Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation. Final report

    SciTech Connect (OSTI)

    Baulch, Janet

    2013-09-11T23:59:59.000Z

    This is a 'glue grant' that was part of a DOE Low Dose project entitled 'Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation'. This collaborative program has involved Drs. David L. Springer from Pacific Northwest National Laboratory (PNNL), John H. Miller from Washington State University, Tri-cities (WSU) and William F. Morgan then from the University of Maryland, Baltimore (UMB). In July 2008, Dr. Morgan moved to PNNL and Dr. Janet E. Baulch became PI for this project at University of Maryland. In November of 2008, a one year extension with no new funds was requested to complete the proteomic analyses. The project stemmed from studies in the Morgan laboratory demonstrating that genomically unstable cells secret a soluble factor or factors into the culture medium, that cause cytogenetic aberrations and apoptosis in normal parental GM10115 cells. The purpose of this project was to identify the death inducing effect (DIE) factor or factors, estimate their relative abundance, identify the cell signaling pathways involved and finally recapitulate DIE in normal cells by exogenous manipulation of putative DIE factors in culture medium. As reported in detail in the previous progress report, analysis of culture medium from the parental cell line, and stable and unstable clones demonstrated inconsistent proteomic profiles as relate to candidate DIE factors. While the proposed proteomic analyses did not provide information that would allow DIE factors to be identified, the analyses provided another important set of observations. Proteomic analysis suggested that proteins associated with the cellular response to oxidative stress and mitochondrial function were elevated in the medium from unstable clones in a manner consistent with mitochondrial dysfunction. These findings correlate with previous studies of these clones that demonstrated functional differences between the mitochondria of stable and unstable clones. These mitochondrial abnormalities in the unstable clones contributes to oxidative stress.

  4. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain

    SciTech Connect (OSTI)

    Lin, Anya M.Y. [Department of Physiology, National Yang-Ming University, Taipei, Taiwan (China); Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chao, P.L.; Fang, S.F.; Chi, C.W. [Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Yang, C.H. [Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan (China)], E-mail: chihyang@ntu.edu.tw

    2007-10-15T23:59:59.000Z

    The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN. Aggregation of {alpha}-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN. From the breakdown pattern of {alpha}-spectrin, both necrosis and apoptosis were involved in the arsenite-induced neurotoxicity. Pyknotic nuclei, cellular shrinkage and cytoplasmic disintegration, indicating necrosis, and TUNEL-positive cells and DNA ladder, indicating apoptosis was observed in the arsenite-infused SN. Arsenite-induced apoptosis was mediated via two different organelle pathways, mitochondria and endoplasmic reticulum (ER). For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels. Moreover, arsenite reduced procaspase 12 levels, an ER-specific enzyme in the infused SN. Taken together, our study suggests that arsenite is capable of inducing oxidative injury in CNS. In addition to mitochondria, ER stress was involved in the arsenite-induced apoptosis. Arsenite-induced neurotoxicity clinically implies a pathophysiological role of arsenite in CNS neurodegeneration.

  5. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    Not Available

    1999-01-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  6. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    NONE

    1999-11-01T23:59:59.000Z

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  7. The Conducting of a Mining Negotiation Showing the Scheme of Engineering Involved

    E-Print Network [OSTI]

    Hansen, George T.

    1911-01-01T23:59:59.000Z

    and capable of lifting the heaviest piece of any one of these machines. CEAIIT BLOCKS:- One fl) 8 ton triplex chain block, complete, equip- ped with sufficient chain for a 14* lift. One (1) 3 ton triplex chain block, equipped with sufficient chain for a 22... E S I S , "The conducting of a Mining negotiation Show- ng the Scheme of Engineering Involved." Taken from Actual Practice 13 7 SEQRGE T. HAISB1 MIIIIS SALES EET5IHEBR ALLIS GHALMBBS OOMPASY ST. LOUIS, MISSOURI Presented to the College...

  8. Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide

    SciTech Connect (OSTI)

    Kurokawa, Yuko; Sekiguchi, Fumiko; Kubo, Satoko; Yamasaki, Yoshiko; Matsuda, Sachi; Okamoto, Yukari; Sekimoto, Teruki; Fukatsu, Anna; Nishikawa, Hiroyuki [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Kume, Toshiaki [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Fukushima, Nobuyuki [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Akaike, Akinori [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Kawabata, Atsufumi, E-mail: kawabata@phar.kindai.ac.jp [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)

    2011-11-04T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Hydrogen sulfide causes NMDA receptor-independent neurotoxicity in mouse fetal cortical neurons. Black-Right-Pointing-Pointer Activation of ERK mediates the toxicity of hydrogen sulfide. Black-Right-Pointing-Pointer Apoptotic mechanisms are involved in the hydrogen-induced cell death. -- Abstract: Hydrogen sulfide (H{sub 2}S), a gasotransmitter, exerts both neurotoxicity and neuroprotection, and targets multiple molecules including NMDA receptors, T-type calcium channels and NO synthase (NOS) that might affect neuronal viability. Here, we determined and characterized effects of NaHS, an H{sub 2}S donor, on cell viability in the primary cultures of mouse fetal cortical neurons. NaHS caused neuronal death, as assessed by LDH release and trypan blue staining, but did not significantly reduce the glutamate toxicity. The neurotoxicity of NaHS was resistant to inhibitors of NMDA receptors, T-type calcium channels and NOS, and was blocked by inhibitors of MEK, but not JNK, p38 MAP kinase, PKC and Src. NaHS caused prompt phosphorylation of ERK and upregulation of Bad, followed by translocation of Bax to mitochondria and release of mitochondrial cytochrome c, leading to the nuclear condensation/fragmentation. These effects of NaHS were suppressed by the MEK inhibitor. Our data suggest that the NMDA receptor-independent neurotoxicity of H{sub 2}S involves activation of the MEK/ERK pathway and some apoptotic mechanisms.

  9. Innocuous oil as an additive for reductive reactions involving zero valence iron

    SciTech Connect (OSTI)

    Cary, J.W.; Cantrell, K.J.

    1994-11-01T23:59:59.000Z

    Reductive reactions involving zero valence iron appear to hold promise for in situ remediation of sites containing chlorinated hydrocarbon solvents and certain reducible metals and radionuclides. Treatment involves the injection of metallic iron and the creation of low levels of dissolved oxygen in the aqueous phase through oxidation of the metallic iron. The use of a biodegradable immiscible and innocuous organic liquid such as vegetable oil as an additive offers several intriguing possibilities. The oil phase creates a large oil-water interface that is immobile with respect to flow in the aqueous phase. This phase will act as a trap for chlorinated hydrocarbons and could potentially increase the reaction efficiency of reductive dehalogenation of chlorinated hydrocarbons by the metallic iron. When iron particles are suspended in the oil before injection they are preferentially held in the oil phase and tend to accumulate at the oil-water interface. Thus oil injection can serve as a mechanism for creating a stable porous curtain of metallic iron in the vadose to maintain a low oxygen environment which will minimize the consumption of the iron by molecular oxygen.

  10. Mechanochemical modeling of dynamic microtubule growth involving sheet-to-tube transition

    E-Print Network [OSTI]

    Xiang-Ying Ji; Xi-Qiao Feng

    2011-08-02T23:59:59.000Z

    Microtubule dynamics is largely influenced by nucleotide hydrolysis and the resultant tubulin configuration changes. The GTP cap model has been proposed to interpret the stabilizing mechanism of microtubule growth from the view of hydrolysis effects. Besides, the microtubule growth involves the closure of a curved sheet at its growing end. The curvature conversion also helps to stabilize the successive growth, and the curved sheet is referred to as the conformational cap. However, there still lacks theoretical investigation on the mechanical-chemical coupling growth process of microtubules. In this paper, we study the growth mechanisms of microtubules by using a coarse-grained molecular method. Firstly, the closure process involving a sheet-to-tube transition is simulated. The results verify the stabilizing effect of the sheet structure, and the minimum conformational cap length that can stabilize the growth is demonstrated to be two dimers. Then, we show that the conformational cap can function independently of the GTP cap, signifying the pivotal role of mechanical factors. Furthermore, based on our theoretical results, we describe a Tetris-like growth style of microtubules: the stochastic tubulin assembly is regulated by energy and harmonized with the seam zipping such that the sheet keeps a practically constant length during growth.

  11. Pseudobond parameters for QM/MM studies involving nucleosides, nucleotides, and their analogs

    SciTech Connect (OSTI)

    Chaudret, Robin [Duke University, North Carolina] [Duke University, North Carolina; Parks, Jerry M [ORNL] [ORNL; Yang, Weitao [Duke University, North Carolina] [Duke University, North Carolina

    2013-01-01T23:59:59.000Z

    In biological systems involving nucleosides, nucleotides, or their respective analogs, the ribose sugar moiety is the most common reaction site, for example, during DNA replication and repair. How- ever, nucleic bases, which comprise a sizable portion of nucleotide molecules, are usually unreactive during such processes. In quantum mechanical/molecular simulations of nucleic acid reactivity, it may therefore be advantageous to describe specific ribosyl or ribosyl phosphate groups quantum me- chanically and their respective nucleic bases with a molecular mechanics potential function. Here, we have extended the pseudobond approach to enable quantum mechanical/molecular mechanical simulations involving nucleotides, nucleosides, and their analogs in which the interface between the two subsystems is located between the sugar and the base, namely, the C(sp3) N(sp2) bond. The pseudobond parameters were optimized on a training set of 10 molecules representing several nu- cleotide and nucleoside bases and analogs, and they were then tested on a larger test set of 20 diverse molecules. Particular emphasis was placed on providing accurate geometries and electrostatic prop- erties, including electrostatic potential, natural bond orbital (NBO) and atoms in molecules (AIM) charges and AIM first moments. We also tested the optimized parameters on five nucleotide and nu- cleoside analogues of pharmaceutical relevance and a small polypeptide (triglycine). Accuracy was maintained for these systems, which highlights the generality and transferability of the pseudobond approach. 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772182

  12. Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through Deuterium Exchange

    E-Print Network [OSTI]

    Crofts, Antony R.

    Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through them. The strength of interactions indicates that the protons are involved in hydrogen bonds with SQ. The hyperfine cou- plings differ from values typical for in-plane hydrogen bonds previously observed in model

  13. To examine how the dynamics of recall processes are affected by the control processes involved with search termination, to study

    E-Print Network [OSTI]

    Dougherty, Michael

    involved with search termination, to study the implications of these control processes for the development at understanding the metacognitive control processes involved with the decision to terminate memory search. Specifically, research examines the impact of search termination decisions on the natural retrieval dynamics

  14. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    SciTech Connect (OSTI)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 ?g/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ? Endothelial HO1 is upregulated by ozonated plasma ? This activation is induced by NRF2 and it is ERK independent. ? 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ? Ozonated plasma induced a hormetic effect ? Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  15. Pore scale modeling of reactive transport involved in geologic CO2 sequestration

    SciTech Connect (OSTI)

    Kang, Qinjin [Los Alamos National Laboratory; Lichtner, Peter C [Los Alamos National Laboratory; Viswanathan, Hari S [Los Alamos National Laboratory; Abdel-fattah, Amr I [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    We apply a multi-component reactive transport lattice Boltzmann model developed in previolls studies to modeling the injection of a C02 saturated brine into various porous media structures at temperature T=25 and 80 C. The porous media are originally consisted of calcite. A chemical system consisting of Na+, Ca2+, Mg2+, H+, CO2(aq), and CI-is considered. The fluid flow, advection and diHusion of aqueous species, homogeneous reactions occurring in the bulk fluid, as weB as the dissolution of calcite and precipitation of dolomite are simulated at the pore scale. The effects of porous media structure on reactive transport are investigated. The results are compared with continuum scale modeling and the agreement and discrepancy are discussed. This work may shed some light on the fundamental physics occurring at the pore scale for reactive transport involved in geologic C02 sequestration.

  16. Involvement of calcium-sensing receptor in ischemia/reperfusion-induced apoptosis in rat cardiomyocytes

    SciTech Connect (OSTI)

    Zhang Weihua [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Fu Songbin [Department of Genetics, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Lu Fanghao [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)]. E-mail: lufanghao1973@yahoo.com.cn; Wu Bo [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Gong Dongmei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Lv Yanjie [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Zhao Yajun [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li Quanfeng [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Wang Rui [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Department of Biology, Lakehead University, Thunder Bay, Ont., P7B5E1 (Canada); Yang Baofeng [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China); Xu Changqing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China) and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150086 (China)]. E-mail: xucq@163.com

    2006-09-08T23:59:59.000Z

    The calcium-sensing receptor (CaR) is a seven-transmembrane G-protein coupled receptor, which activates intracellular effectors, for example, it causes inositol phosphate (IP) accumulation to increase the release of intracellular calcium. Although intracellular calcium overload has been implicated in the cardiac ischemia/reperfusion (I/R)-induced apoptosis, the role of CaR in the induction of apoptosis has not been fully understood. This study tested the hypothesis that CaR is involved in I/R cardiomyocyte apoptosis by increasing [Ca{sup 2+}]{sub i}. The isolated rat hearts were subjected to 40-min ischemia followed by 2 h of reperfusion, meanwhile GdCl{sub 3} was added to reperfusion solution. The expression of CaR increased at the exposure to GdCl{sub 3} during I/R. By laser confocal microscopy, it was observed that the intracellular calcium was significantly increased and exhibited a collapsed {delta}{psi} {sub m}, as monitored by 5,5',6,6'-tetrachloro-1,1',3,3'- tetraethylbenzimidazolcarbocyanine iodide (JC-1) during reperfusion with GdCl{sub 3}. Furthermore, the number of apoptotic cells was significantly increased as shown by TUNEL assay. Typical apoptotic cells were observed with transmission electron microscopy in I/R with GdCl{sub 3} but not in the control group. The expression of cytosolic cytochrome c and activated caspase-9 and caspase-3 was significantly increased whereas the expression of mitochondrial cytochrome c significantly decreased in I/R with GdCl{sub 3} in comparison to the control. In conclusion, these results suggest that CaR is involved in the induction of cardiomyocyte apoptosis during ischemia/reperfusion through activation of cytochrome c-caspase-3 signaling pathway.

  17. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway

    SciTech Connect (OSTI)

    Zhang, Huijuan; Tan, Shi; Wang, Juan; Chen, Shana; Quan, Jing; Xian, Jingrong; Zhang, Shuai shuai; He, Jingang; Zhang, Ling, E-mail: lingzhang@cqmu.edu.cn

    2014-01-01T23:59:59.000Z

    The RNA-binding protein Musashi2 (Msi2) has been identified as a master regulator within a variety of stem cell populations via the regulation of translational gene expression. A recent study has suggested that Msi2 is strongly expressed in leukemic cells of acute myeloid leukemia patients, and elevated Msi2 is associated with poor prognosis. However, the potential role of Msi2 in leukemogenesis is still not well understood. Here, we investigated the effect of Msi2 knockdown on the biological properties of leukemic cells. High expression of Msi2 was found in K562 and KG-1a leukemic cell lines, and low expression was observed in the U937 cell line. We transduced K562 cells with two independent adenoviral shRNA vectors targeting Msi2 and confirmed knockdown of Msi2 at the mRNA and protein levels. Msi2 silencing inhibited cell growth and caused cell cycle arrest by increasing the expression of p21 and decreasing the expression of cyclin D1 and cdk2. In addition, knockdown of Msi2 promoted cellular apoptosis via the upregulation of Bax and downregulation of Bcl-2 expression. Furthermore, Msi2 knockdown resulted in the inactivation of the ERK/MAPK and p38/MAPK pathways, but no remarkable change in p-AKT was observed. These data provide evidence that Msi2 plays an important role in leukemogenesis involving the MAPK signaling pathway, which indicates that Msi2 may be a novel target for leukemia treatment. - Highlights: • Knockdown of Msi2 inhibited K562 cell growth and arrested cell cycle progression. • Knockdown of Msi2 induced K562 cell apoptosis via the regulation of Bax and Bcl-2. • The MAPK pathway was involved in the process of Msi2-mediated leukemogenesis. • Our data indicate that Msi2 is a potential new target for leukemia treatment.

  18. The Orosomucoid 1 protein is involved in the vitamin D – mediated macrophage de-activation process

    SciTech Connect (OSTI)

    Gemelli, Claudia, E-mail: claudia.gemelli@unimore.it [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy); Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, 41125 Modena (Italy); Martello, Andrea; Montanari, Monica; Zanocco Marani, Tommaso; Salsi, Valentina; Zappavigna, Vincenzo; Parenti, Sandra; Vignudelli, Tatiana; Selmi, Tommaso; Ferrari, Sergio; Grande, Alexis [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy)

    2013-12-10T23:59:59.000Z

    Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties. The present study was designed to identify a possible correlation between ORM1 and Vitamin D3 (1,25(OH)2D3), a hormone exerting a widespread effect on cell proliferation, differentiation and regulation of the immune system. In particular, the data described here indicated that ORM1 is a 1,25(OH)2D3 primary response gene, characterized by the presence of a VDRE element inside the 1 kb sequence of its proximal promoter region. This finding was demonstrated with gene expression studies, Chromatin Immunoprecipitation and luciferase transactivation experiments and confirmed by VDR full length and dominant negative over-expression. In addition, several experiments carried out in human normal monocytes demonstrated that the 1,25(OH)2D3 – VDR – ORM1 pathway plays a functional role inside the macrophage de-activation process and that ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. - Highlights: • ORM1 is a Vitamin D primary response gene. • VD and its receptor VDR are involved in the de-activation process mediated by human resident macrophages. • The signaling pathway VD-VDR-ORM1 plays an important role in the control of macrophage de-activation process. • ORM1 may be defined as a signaling molecule implicated in the maintenance of tissue homeostasis and remodeling.

  19. 6/6/2014 1 of 6 OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals

    E-Print Network [OSTI]

    Kay, Mark A.

    OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals I. OVERVIEW Hazardous Chemicals: Known or suspect carcinogens, reproductive toxins or other highly toxic substances (e. Reference the SU Chemical Hygiene Plan for hazardous chemical definitions. Potential Exposures: Research

  20. Interactions among College and University Faculty and Students Involved in Academic Student Organizations: An Analysis of Qualitative and Quantitative Engagement

    E-Print Network [OSTI]

    Holzweiss, Peggy Carol

    2011-10-21T23:59:59.000Z

    The purpose of this study was to describe what kind of student-faculty interactions are occurring in the context of academic student organizations as well as identify the quality and quantity of such interactions and what factors are involved...

  1. Supply chain management (SCM) involves the management of materials and information across the entire supply chain. This includes raw material

    E-Print Network [OSTI]

    Calgary, University of

    Supply chain management (SCM) involves the management of materials and information across this concentration will be required to take three core courses: Materials and Supply Chain Management, Transportation Purchasing identify global sources of materials, select vendors, and manage negotiati

  2. Talking about living and dying with the oldest old: public involvement in a study on end of life care in care homes.

    E-Print Network [OSTI]

    Goodman, Claire; Mathie, Elspeth; Cowe, Marion; Mendoza, Alex; Westwood, Daphne; Munday, Diane; Wilson, Patricia M; Crang, Clare; Froggatt, Katherine; Iliffe, Steve; Manthorpe, Jill; Gage, Heather; Barclay, Stephen

    2011-11-23T23:59:59.000Z

    , governance and safeguarding, and the discussion and interpretation of emergent findings with the older people living in the care homes. PPI as collaborators in the recruitment process Recruitment to the study was a staged process, that involved securing care... expressed doubts about participation Table 1 Public involvement in different stages of research process PIR Involvement Level of Involvement Study Design Input on grant proposal and development of method for public involvement within the study Steering...

  3. The Effects of an Intervention to Foster a Caring and Task-Involving Climate at a University Recreation Center

    E-Print Network [OSTI]

    Brown, Theresa Clare

    2011-04-21T23:59:59.000Z

    using constructs from the POMS (depression, anxiety, fearful, fatigue, hostility; Usala & 18 Hertzog, 1989). An advantage of the instruments selected is there flexibility for the researcher to 19 indicate time frame (Pressman & Cohen, 2005...-Being, Self-Assuredness, Attentiveness) 6 were positively related to the task-involving climate. All but fatigue of the negative mood states 7 (i.e., Depressed, Anxiety, Hostility, Fearful) were positively associated to the ego-involving 8 climate...

  4. Elementary Act of Consciousness or Cycle of Mind, involving Distant and Nonlocal Interaction

    E-Print Network [OSTI]

    Alex Kaivarainen

    2007-09-11T23:59:59.000Z

    Each macroscopic process can be subdivided on the quantum and classical stages. Particularly, the quantum stages of Cycle of Mind involves:1) the stimulation of dynamic correlation between water clusters in the same and remote microtubules (MTs) in state of mesoscopic Bose condensation (mBC) by phonons (acoustic waves) and by librational IR photons (electromagnetic-EM waves) distant exchange; 2) the transition from distant EM interaction between remote MTs to nonlocal quantum interaction, induced by IR photons exchange between clusters, the clusters Virtual Replicas multiplication (VRM) and virtual guides (VirG) formation between elementary particles of remote coherent water molecules. This process represents transition from mesoscopic Bose condensation to macroscopic nonuniform semi-virtual Bose condensation (VirBC) (Kaivarainen, 2006, http://arxiv.org/abs/physics/0207027); 3) the collapsing of corresponding macroscopic wave function, as a result of the optical bistability of the entangled water clusters and their disassembly due to librational photons pumping, shifting clusters to less stable state; 4) turning the clusterphilic interaction between water clusters in the open state of cavities between alpha and beta tubulins to hydrophobic one and the in-phase shift of these cavities to the closed state due to clusters disassembly (Kaivarainen, http://arxiv.org/abs/physics/0102086). The classical stages of our Hierarchic model of elementary act of Cycle of Mind are analyzed in detail.

  5. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19T23:59:59.000Z

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  6. Depletion of bovine pituitary prolactin by cysteamine involves a thiol:disulfide mechanism

    SciTech Connect (OSTI)

    Lorenson, M.Y.; Jacobs, L.S.

    1984-10-01T23:59:59.000Z

    Cysteamine (2-aminoethanethiol (CySH)) reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily assayable, releasable PRL. This would represent a previously unrecognized mechanism for secretory regulation. We undertook the present study to identify the sites involved in the loss of measurable PRL (depletion) induced by cysteamine. The disulfide cystamine was ineffective on secretory granules unless combined with reduced glutathione, indicating the generation of the active CySH-thiol form. Pretreatment of granules with thiol-blocking agents resulted in dose-dependent enhancement of CySH inhibition, achieving nearly complete inhibition with 5 mM iodoacetamide. In contrast, pretreatment with reduced glutathione or dithiothreitol, respectively, impaired or abolished the CySH effect. These data suggest that the mechanism by which CySH causes PRL depletion is mediated by granule disulfides and the -SH of CySH. The regulation of thiol:disulfide equilibria appears to be an important determinant of the detectability of PRL storage forms and of their secretion.

  7. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis

    SciTech Connect (OSTI)

    Pauly, Markus; Sorensen, Susanne Oxenboll; Harholt, Jesper; Geshi, Naomi; Sakuragi, Yumiko; Moller, Isabel; Zandleven, Joris; Bernal, Adriana J.; Jensen, Niels Bjerg; Sorensen, Charlotte; Jensen, Jacob K.; Beldman, Gerrit; Willats, William G.T.; Scheller, Henrik

    2009-08-19T23:59:59.000Z

    Xylogalacturonan (XGA) is a class of pectic polysaccharide found in plant cell walls. The Arabidopsis thaliana locus At5g33290 encodes a predicted Type II membrane protein, and insertion mutants of the At5g33290 locus had decreased cell wall xylose. Immunological studies, enzymatic extraction of polysaccharides, monosaccharide linkage analysis, and oligosaccharide mass profiling were employed to identify the affected cell wall polymer. Pectic XGA was reduced to much lower levels in mutant than in wild-type leaves, indicating a role of At5g33290 in XGA biosynthesis. The mutated gene was designated xylogalacturonan deficient1 (xgd1). Transformation of the xgd1-1 mutant with the wild-type gene restored XGA to wild-type levels. XGD1 protein heterologously expressed in Nicotiana benthamiana catalyzed the transfer of xylose from UDP-xylose onto oligogalacturonides and endogenous acceptors. The products formed could be hydrolyzed with an XGA-specific hydrolase. These results confirm that the XGD1 protein is a XGA xylosyltransferase. The protein was shown by expression of a fluorescent fusion protein in N. benthamiana to be localized in the Golgi vesicles as expected for a glycosyltransferase involved in pectin biosynthesis.

  8. From public participation to stakeholder involvement: The rocky road to more inclusiveness

    SciTech Connect (OSTI)

    Peelle, E.

    1995-07-01T23:59:59.000Z

    Surviving always at the edge of extinction, public participation in environmental decision making has an uncertain and problematic history. From its emergence from the urban planning and delivery system efforts of the 1960s to many siting and non-siting uses today, it remains a battleground, with few successes and many failures. While some compelling structural, organizational and cultural explanations for this state of affairs exist, the author offers a further one--a too-limited definition and vision of public participation. One then can argue for a more inclusive process such as stakeholder involvement (SI) to enable a more viable approach to decision making. One can argue that the narrow conceptualization offered in the term public participation (PP) is partly responsible for the meager results of decades of efforts by earnest practitioners. Because of the limited, unique, and self-selected publics that respond to the major PP mechanisms such as public hearings, PP has become largely the province of organized activist groups and is largely accepted as such by most parties, including PP professionals. The author reviews the roles of Congress, federal agencies/proponents, local governments, activist groups and PP professionals in creating the current limited PP processes. She discusses trends and prospects for moving to broader based, more inclusive SI approaches. The emerging SI approach presents major methodological and organizational challenges, but offers the promise of outcomes more likely to be legitimated and potentially more lasting.

  9. Involvement of the transcription factor FoxM1 in contact inhibition

    SciTech Connect (OSTI)

    Faust, Dagmar; Al-Butmeh, Firas; Linz, Berenike [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany); Dietrich, Cornelia, E-mail: cdietric@uni-mainz.de [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)

    2012-10-05T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer The transcription factor FoxM1 is downregulated upon contact inhibition. Black-Right-Pointing-Pointer The decrease in FoxM1 levels occurs very likely due to inhibition of ERK activity. Black-Right-Pointing-Pointer The decrease in FoxM1 is not sufficient, but required for contact inhibition. Black-Right-Pointing-Pointer We propose a new model of contact inhibition involving pRB/E2F and FoxM1. -- Abstract: Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Although it is generally accepted that contact inhibition plays a pivotal role in maintaining tissue homeostasis, the molecular mechanisms of contact inhibition are still not fully understood. FoxM1 is known as a proliferation-associated transcription factor and is upregulated in many cancer types. Vice versa, anti-proliferative signals, such as TGF-{beta} and differentiation signals decrease FoxM1 expression. Here we investigated the role of FoxM1 in contact inhibition in fibroblasts. We show that protein expression of FoxM1 is severely and rapidly downregulated upon contact inhibition, probably by inhibition of ERK activity, which then leads to decreased expression of cyclin A and polo-like kinase 1. Vice versa, ectopic expression of FoxM1 prevents the decrease in cyclin A and polo-like kinase 1 and causes a two-fold increase in saturation density indicating loss of contact inhibition. Hence, we show that downregulation of FoxM1 is required for contact inhibition by regulating expression of cyclin A and polo-like kinase 1.

  10. Issues Involving The OSI Concept of Operation For Noble Gas Radionuclide Detection

    SciTech Connect (OSTI)

    Carrigan, C R; Sun, Y

    2011-01-21T23:59:59.000Z

    The development of a technically sound protocol for detecting the subsurface release of noble gas radionuclides is critical to the successful operation of an on site inspection (OSI) under the CTBT and has broad ramifications for all aspects of the OSI regime including the setting of specifications for both sampling and analysis equipment used during an OSI. With NA-24 support, we are investigating a variety of issues and concerns that have significant bearing on policy development and technical guidance regarding the detection of noble gases and the creation of a technically justifiable OSI concept of operation. The work at LLNL focuses on optimizing the ability to capture radioactive noble gases subject to the constraints of possible OSI scenarios. This focus results from recognizing the difficulty of detecting gas releases in geologic environments - a lesson we learned previously from the LLNL Non-Proliferation Experiment (NPE). Evaluation of a number of important noble gas detection issues, potentially affecting OSI policy, has awaited the US re-engagement with the OSI technical community. Thus, there have been numerous issues to address during the past 18 months. Most of our evaluations of a sampling or transport issue necessarily involve computer simulations. This is partly due to the lack of OSI-relevant field data, such as that provided by the NPE, and partly a result of the ability of LLNL computer-based models to test a range of geologic and atmospheric scenarios far beyond what could ever be studied in the field making this approach very highly cost effective. We review some highlights of the transport and sampling issues we have investigated during the past year. We complete the discussion of these issues with a description of a preliminary design for subsurface sampling that is intended to be a practical solution to most if not all the challenges addressed here.

  11. Public Involvement Plan Public Involvement Plan

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHASeptember 2010 |ofDepartment ofPart 1021 | DepartmentofAPublic

  12. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    SciTech Connect (OSTI)

    Houseworth, Jim; Rutqvist, Jonny; Asahina, Daisuke; Chen, Fei; Vilarrasa, Victor; Liu, Hui-Hai; Birkholzer, Jens

    2013-11-06T23:59:59.000Z

    Nuclear waste programs outside of the US have focused on different host rock types for geological disposal of high-level radioactive waste. Several countries, including France, Switzerland, Belgium, and Japan are exploring the possibility of waste disposal in shale and other clay-rich rock that fall within the general classification of argillaceous rock. This rock type is also of interest for the US program because the US has extensive sedimentary basins containing large deposits of argillaceous rock. LBNL, as part of the DOE-NE Used Fuel Disposition Campaign, is collaborating on some of the underground research laboratory (URL) activities at the Mont Terri URL near Saint-Ursanne, Switzerland. The Mont Terri project, which began in 1995, has developed a URL at a depth of about 300 m in a stiff clay formation called the Opalinus Clay. Our current collaboration efforts include two test modeling activities for the FE heater test and the HG-A leak-off test. This report documents results concerning our current modeling of these field tests. The overall objectives of these activities include an improved understanding of and advanced relevant modeling capabilities for EDZ evolution in clay repositories and the associated coupled processes, and to develop a technical basis for the maximum allowable temperature for a clay repository. The R&D activities documented in this report are part of the work package of natural system evaluation and tool development that directly supports the following Used Fuel Disposition Campaign (UFDC) objectives: ? Develop a fundamental understanding of disposal-system performance in a range of environments for potential wastes that could arise from future nuclear-fuel-cycle alternatives through theory, simulation, testing, and experimentation. ? Develop a computational modeling capability for the performance of storage and disposal options for a range of fuel-cycle alternatives, evolving from generic models to more robust models of performance assessment. For the purpose of validating modeling capabilities for thermal-hydro-mechanical (THM) processes, we developed a suite of simulation models for the planned full-scale FE Experiment to be conducted in the Mont Terri URL, including a full three-dimensional model that will be used for direct comparison to experimental data once available. We performed for the first time a THM analysis involving the Barcelona Basic Model (BBM) in a full three-dimensional field setting for modeling the geomechanical behavior of the buffer material and its interaction with the argillaceous host rock. We have simulated a well defined benchmark that will be used for codeto- code verification against modeling results from other international modeling teams. The analysis highlights the complex coupled geomechanical behavior in the buffer and its interaction with the surrounding rock and the importance of a well characterized buffer material in terms of THM properties. A new geomechanical fracture-damage model, TOUGH-RBSN, was applied to investigate damage behavior in the ongoing HG-A test at Mont Terri URL. Two model modifications have been implemented so that the Rigid-Body-Spring-Network (RBSN) model can be used for analysis of fracturing around the HG-A microtunnel. These modifications are (1) a methodology to compute fracture generation under compressive stress conditions and (2) a method to represent anisotropic elastic and strength properties. The method for computing fracture generation under compressive load produces results that roughly follow trends expected for homogeneous and layered systems. Anisotropic properties for the bulk rock were represented in the RBSN model using layered heterogeneity and gave bulk material responses in line with expectations. These model improvements were implemented for an initial model of fracture damage at the HG-A test. While the HG-A test model results show some similarities with the test observations, differences between the model results and observations remain.

  13. Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of

    E-Print Network [OSTI]

    Radeloff, Volker C.

    Global trade in dairy products involves complex and con- tentious issues. Viewed broadly from the perspective of "society," there are large benefits from liberalizing trade. Viewed narrowly from the perspective of dairy producers, liberalized trade is desirable only if it expands exports and reduces imports

  14. Project Brief: These works, part of the project to complete the RSM and Bessemer Buildings, involve refurbishment of level 3

    E-Print Network [OSTI]

    Project Brief: These works, part of the project to complete the RSM and Bessemer Buildings, involve London and acts as a focus for interdisciplinary research into nanoscale materials. It attracts academics in this field, fuelled by the prospect of a new generation of high performance materials with applications

  15. Abstract--Network security against possible attacks involves making decisions under uncertainty. Not only may one be

    E-Print Network [OSTI]

    ], security in wireless networks [12], [13] and cyber-security [14], [15], [16]. In [17] the readers can find1 Abstract--Network security against possible attacks involves making decisions under uncertainty for a further DDoS (Distributed Denial of Service) botnet attack on servers). Due to limited defense

  16. Abstract --The growth of non-conventional renewable energies involves a new challenge for optimal network expansion. A better

    E-Print Network [OSTI]

    Catholic University of Chile (Universidad Católica de Chile)

    1 Abstract -- The growth of non-conventional renewable energies involves a new challenge and implementation of policies to develop Non-Conventional Renewable Energies (NCRE), they can be seen as a mechanism for optimal network expansion. A better integration of renewables will be allowed by determining transmission

  17. Japan, EU adamant about their proposals to host ITER, put off negotiations to next year; Joint construction plan involving Japan,

    E-Print Network [OSTI]

    Japan, EU adamant about their proposals to host ITER, put off negotiations to next year; Joint construction plan involving Japan, U.S. South Korea also emerging NIHON KEIZAI, December 20, 2004 Japan are likely to enter a crucial stage early in the next year. In addition to Japan and the EU, the United

  18. Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

    E-Print Network [OSTI]

    Linial, Michal

    Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release kinase (ERK)/mitogen-activated protein kinase (MAPK) in pardaxin-induced dopamine (DA) release DA release. Time course exper- iments indicated that PX, at nontoxic concentrations, stimu- lated ERK

  19. Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping

    E-Print Network [OSTI]

    TDG Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping and receiving. All receiving of Dangerous Goods for the Science in Departmental Offices or labs. How do you know if the package is a dangerous goods shipment? Parcels containing

  20. 162 Electrical and Computer Engineering 163 Courses and projects that actively involve them in their own education and

    E-Print Network [OSTI]

    Richards-Kortum, Rebecca

    162 Electrical and Computer Engineering 163 · Courses and projects that actively involve them · A broad education outside of engineering and science that emphasizes the role of electrical and computer of technology Graduate and undergraduate programs in electrical and computer engineering offer concentrations

  1. "The Greek community will strive for excellence in scholarship, service, leadership, involvement, diversity, building community, and brotherhood/sisterhood."

    E-Print Network [OSTI]

    Linhardt, Robert J.

    fully support our project. As a model for chapter house budgeting and house operation, as well 1255 students) are leading the sustainability effort on campus with their Green Greeks vision and plan involved in class projects and coursework, and increase the sustainability of the Rensselaer community

  2. What is Your Environmental Wellness? The environmental dimension involves accepting the impact we have on our world and doing something

    E-Print Network [OSTI]

    sprays. _____ 7. I do not litter. _____ 8. I volunteer my time for environmental conservation projectsWhat is Your Environmental Wellness? The environmental dimension involves accepting the impact we points _____ 1. I consciously conserve energy (electricity, heat, light, water, etc.) in my place

  3. CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax Production

    E-Print Network [OSTI]

    Kunst, Ljerka

    CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax surfaces of land plants. It is composed of a cutin polymer matrix and waxes. Cuticular waxes are complex and characterization of CER4, a wax bio- synthetic gene from Arabidopsis (Arabidopsis thaliana). Arabidopsis cer4

  4. TERC Research in the Chilean Patagonia TERC is involved in a collaborative research effort with the EULA Center of the

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    TERC Research in the Chilean Patagonia TERC is involved in a collaborative research effort of the Chilean Patagonia. The lakes, rivers, glaciers, wetlands and other aquatic environments of the Chilean Patagonia offer a globally unique opportunity for science. They represent the most undisturbed aquatic

  5. Control of Major-Accident Hazards Involving Land Transmission Charlotte BOUISSOU, Project Manager for Pipelines Risk Assessment

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    aims to help authorities to balance the requirement of the new pipeline regulation with regardsControl of Major-Accident Hazards Involving Land Transmission Pipelines Charlotte BOUISSOU, Project Manager for Pipelines Risk Assessment Sandrine DESCOURRIERE, Project Manager for Plants Risk Assessment

  6. Abstract--This paper reports on studies involving brain-machine interfaces (BMIs) that provide near-instantaneous

    E-Print Network [OSTI]

    Guenther, Frank

    Abstract--This paper reports on studies involving brain- machine interfaces (BMIs) that provide output. I. INTRODUCTION ECENT years have seen the development of brain- machine interfaces (BMIs or electroencephalography (EEG). In the current paper we focus on a specific subset of brain-machine interfaces: those aimed

  7. Development and application of a hybrid method involving interpolation and ab initio calculations for the determination of transition states

    E-Print Network [OSTI]

    Bell, Alexis T.

    optimization P-RFO method. Such methods tend to work well if information about the potential energy surfaceDevelopment and application of a hybrid method involving interpolation and ab initio calculations scheme was used to estimate the energy and gradient, thereby reducing the calls to the quantum mechanical

  8. Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate regulation of chlorophyll a oxygenase (CAO)

    E-Print Network [OSTI]

    Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate and that of the Lhcb genes in the model organism Dunaliella salina. Among the chlorophyll biosynthesis enzymes tested are a dynamic compensation response (Melis, 1996; 1998). When HL-acclimated cells of D. salina were shifted

  9. Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP, Bruce D. Hammock, Elizabeth Murphy, Darryl C. Zeldin Abstract--Human CYP2J2 is abundant in heart and its eicosanoid products in the heart remains unknown. Transgenic mice with cardiomyocyte

  10. Most fish have a forward undulatory swimming mechanism that involves a kinematic propulsive wave travelling down the

    E-Print Network [OSTI]

    D'Août, Kristiaan

    Most fish have a forward undulatory swimming mechanism that involves a kinematic propulsive wave backwards in a similar way. We compared the kinematics (wave speed, cycle frequency, amplitude, local in the direction opposite to that of swimming. We observe two major kinematic differences. First, the slope of wave

  11. A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved in Differentiation of Trypomastigotes to

    E-Print Network [OSTI]

    Singer, Randall

    A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved C (PI- PLC) is an important component of the inositol phos- phate/diacylglycerol signaling pathway. A newly discov- ered Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N terminus, targeted

  12. Nonadiabatic dynamics for processes involving multiple avoided curve crossings: Double proton transfer and proton-coupled electron transfer

    E-Print Network [OSTI]

    Hammes-Schiffer, Sharon

    Nonadiabatic dynamics for processes involving multiple avoided curve crossings: Double proton transfer and proton-coupled electron transfer reactions Jian-Yun Fang and Sharon Hammes June 1997; accepted 26 August 1997 The extension of the surface hopping method ``molecular dynamics

  13. Thomas Meyer Basic Infobase Change Abstract. Generalisations of theory change involving arbitrary sets of w s instead of

    E-Print Network [OSTI]

    Meyer, Tommie

    Thomas Meyer Basic Infobase Change Abstract. Generalisations of theory change involving arbitrary these lines by Meyer et al. 15]. We take an infobase as a nite sequence of w s, with each element Kluwer Academic Publishers. Printed in the Netherlands. #12;216 T. Meyer In this paper we propose a form

  14. Using Software Development Standards to Analyse Accidents Involving Electrical, Electronic or Programmable, Electronic Systems: The Blade Mill PLC Case Study

    E-Print Network [OSTI]

    Johnson, Chris

    -1- Using Software Development Standards to Analyse Accidents Involving Electrical, Electronic developed by the US Department of Energy (1992). The intention is that both the lightweight flowcharts's (HSE) mission is to ensure that risks to people's health and safety from work activities are properly

  15. The molecular mechanisms involved in the genetic instability of the CCTG. CAGG repeats associated with myotonic dystrophy type 2

    E-Print Network [OSTI]

    Dere, Ruhee J.

    2006-08-16T23:59:59.000Z

    THE MOLECULAR MECHANISMS INVOLVED IN THE GENETIC INSTABILITY OF THE CCTG?CAGG REPEATS ASSOCIATED WITH MYOTONIC DYSTROPHY TYPE 2 A Dissertation by RUHEE J. DERE Submitted to the Office of Graduate Studies of Texas A&M University... TYPE 2 A Dissertation by RUHEE J. DERE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree...

  16. Exploring the Behavioral and Psychological Differences between Male and Female Youth with a History of Fire Involvement

    E-Print Network [OSTI]

    Morris, Ed M.

    2014-08-31T23:59:59.000Z

    . While it is supported that fire-involved youth tend to be males, recent statistics published by the National Fire Protection Association (NFPA) indicated sex differences in the type of fires set. Specifically, the NFPA report found that female youth... expression and found it surprising that females were associated with covert emotional expression through firesetting behavior because they are typically socialized to express emotions overtly. If the female-dominated structure fires documented by NFPA...

  17. Examining students' perceptions of study abroad programs involving sport through application of the social cognitive career theory

    E-Print Network [OSTI]

    Jones, Gregory C.

    2009-06-02T23:59:59.000Z

    OF SCIENCE Approved by: Chair of Committee, George B. Cunningham Committee Members, Michael Sagas Ben Welch Head of Department, Steve Dorman August 2006 Major Subject: Kinesiology iii ABSTRACT Examining Students...? Perceptions of Study Abroad Programs Involving Sport Through Application of the Social Cognitive Career Theory. (August 2006) Gregory C. Jones, B.S., Sam Houston State University Chair of Advisory Committee: Dr. George B. Cunningham With sport...

  18. The effects of ego-involvement with the task upon the self-esteem/task performance relationship

    E-Print Network [OSTI]

    Nilles, Carol Anne

    1983-01-01T23:59:59.000Z

    study by Cottrell (1965). Not all of the research results involving task-speci- fic self-esteem have supported Korman's consistency theo- ry, however, As previously mentioned, several studies have yielded only partial support. Cohen and Lefkowitz... are motivated to maintain consistency between their self-esteem and their task performance (Korman, 1970). The research evidence re- garding this contention has generally been mixed. While numerous studies have provided support for Korman's con- sistency...

  19. THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

    SciTech Connect (OSTI)

    Ann M. Beauchesne

    2000-01-01T23:59:59.000Z

    Through the National Governors Association (NGA) project ``Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials; Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities; Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites in the complex; Changes to the FFCA site treatment plans as a result of proposals in the Department's Accelerating Cleanup: Paths to Closure plan and contractor integration analysis; Interstate waste and materials shipments; and Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the period from October 1, 1999 through January 31, 2000, under the NGA grant. The work accomplished by the NGA project team during the past three months can be categorized as follows: maintained open communication with DOE on a variety of activities and issues within the DOE environmental management complex; convened and facilitated the October 6--8 NGA FFCA Task Force Meeting in Oak Ridge, Tennessee; maintained communication with NGA Federal Facilities Compliance Task Force members regarding DOE efforts to formulate a configuration for mixed low-level waste and low-level treatment and disposal, external regulation of DOE; and continued to facilitate interactions between the states and DOE to develop a foundation for an ongoing substantive relationship between the Governors of key states and the Department.

  20. THE NGA-DOE GRANT TO EXAMINE CRITICAL ISSUES RELATED TO RADIOACTIVE WASTE AND MATERIALS DISPOSITION INVOLVING DOE FACILITIES

    SciTech Connect (OSTI)

    NONE

    1998-07-01T23:59:59.000Z

    Through the National Governors' Association (NGA) project ''Critical Issues Related to Radioactive Waste and Materials Disposition Involving DOE Facilities'' NGA brings together Governors' policy advisors, state regulators, and DOE officials to examine critical issues related to the cleanup and operation of DOE nuclear weapons and research facilities. Topics explored through this project include: Decisions involving disposal of mixed, low-level, and transuranic (TRU) waste and disposition of nuclear materials. Decisions involving DOE budget requests and their effect on environmental cleanup and compliance at DOE facilities. Strategies to treat mixed, low-level, and transuranic (TRU) waste and their effect on individual sites in the complex. Changes to the FFCA site treatment plans as a result of proposals in DOE's Accelerating Cleanup: Paths to Closure strategy and contractor integration analysis. Interstate waste and materials shipments. Reforms to existing RCRA and CERCLA regulations/guidance to address regulatory overlap and risks posed by DOE wastes. The overarching theme of this project is to help the Department improve coordination of its major program decisions with Governors' offices and state regulators and to ensure such decisions reflect input from these key state officials and stakeholders. This report summarizes activities conducted during the quarter from April 30, 1998 through June 30, 1998 under the NGA project. The work accomplished by the NGA project team during the past four months can be categorized as follows: maintained open communication with DOE on a variety of activities and issues within the DOE environmental management complex; and provided ongoing support to state-DOE interactions. maintained communication with NGA Federal Facilities Compliance Task Force members regarding DOE efforts to formulate a configuration for mixed low-level waste and low-level treatment and disposal, DOE's Environmental Management Budget, and DOE's proposed Intersite Discussions.

  1. Factors involved in the seasonal and geographical regulation of diapause in the boll weevil, Anthonomus grandis Boheman

    E-Print Network [OSTI]

    Sterling, W. L

    1966-01-01T23:59:59.000Z

    FACTORS INVOLVED IN 'ZHE SEASONAL AND GEOGEAPNICAL EMQULATION OF DIAPAUSE Ill ttlL BOLL itl' 'VIL I~it&I UNOiliUG OtOtBDIB BOtlIIiBB A thesis by Ninfield Linsoln Sterling Submitted to the Qraduate College of Texas AM Universe. tp in Fartial... under tsy water in wxuc-bottom disseotion dishes. Elgtrae and hind wings were removed and disseotions maCe un4ex' a miorosooye at S0s image. Gne ohaxeoter used fox' the determination of 4iayause was Che hyyertroyhS of Che abdominal fat body...

  2. Use of a Trellis Device for Endovascular Treatment of Venous Thrombosis Involving a Duplicated Inferior Vena Cava

    SciTech Connect (OSTI)

    Saettele, Megan R., E-mail: SaetteleM@umkc.edu [University of Missouri, Kansas City, Department of Radiology, Saint Luke's Hospital (United States); Morelli, John N., E-mail: dr.john.morelli@gmail.com [Texas A and M University Health Science Center, Department of Radiology, Scott and White Clinic and Hospital (United States); Chesis, Paul; Wible, Brandt C. [University of Missouri, Kansas City, Department of Interventional Radiology, Saint Luke's Hospital (United States)] [University of Missouri, Kansas City, Department of Interventional Radiology, Saint Luke's Hospital (United States)

    2013-12-15T23:59:59.000Z

    Congenital anomalies of the inferior vena cava (IVC) are increasingly recognized with CT and venography techniques. Although many patients with IVC anomalies are asymptomatic, recent studies have suggested an association with venous thromboembolism. We report the case of a 62-year-old woman with extensive venous clot involving the infrarenal segment of a duplicated left IVC who underwent pharmacomechanical thrombectomy and tissue plasminogen activator catheter-directed thrombolysis with complete deep venous thrombosis resolution. To our knowledge this is the first reported case in the English literature of the use of a Trellis thrombectomy catheter in the setting of duplicated IVC.

  3. Parent Involvement (Spanish) 

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10T23:59:59.000Z

    producidas por el servicio de Extensi?n en el Internet: http://tcebookstore.org Los programas educativos del Servicio de Extensi?n Agr?cola de Texas est?n disponibles para todas las personas, sin distinci?n de raza, color, sexo, minusvalidez, religi?n, edad...

  4. Parent Involvement (Spanish)

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10T23:59:59.000Z

    producidas por el servicio de Extensi?n en el Internet: http://tcebookstore.org Los programas educativos del Servicio de Extensi?n Agr?cola de Texas est?n disponibles para todas las personas, sin distinci?n de raza, color, sexo, minusvalidez, religi?n, edad...

  5. Involvement & Outreach

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > The Energy Materials Center atdiffusivities in mesopores |Business

  6. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor and entrepreneurBudget

  7. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor and

  8. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor andPublic

  9. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes | NationalCurriculum IntroductionInvestor andPublicTank Waste

  10. Commitment to Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would like submit the following commentsCurrent-Promotions015 NMMSS

  11. TPA Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our InstagramStructureProposedPAGE Creating a Geologic Play BookEnergyTOj

  12. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Ruben A. Abagyan, PhD

    2004-04-15T23:59:59.000Z

    OAK-B135 DNA Damage Recognition and Repair (DDR and R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. the authors have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR and R process. The significant achievements of this project include: (1) Construction of the computational pipeline for searching DDR and R genes, building and validation of 3D models of proteins involved in DDR and R; (2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; (3) Important improvement of macromolecular docking technology and its application to predict the DNA-Protein complex conformation; (4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; (5) Construction and maintenance of the DNA Damage Recognition and Repair Database; and (6) Producing 14 research papers (10 published and 4 in preparation).

  13. Involvement of VAMP-2 in exocytosis of IL-1{beta} in turbot (Scophthalmus maximus) leukocytes after Vibrio anguillarum infection

    SciTech Connect (OSTI)

    Chai Yingmei [Department of Life Science, Ocean University of China, Qingdao 266003 (China); Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China); College of Marine Life Sciences, Shandong University at Weihai, Weihai 264209 (China); Huang Xiaohang [Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China)]. E-mail: xiaohanghuang@yahoo.ca; Cong Bailin [Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China); Liu Shenghao [Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China); Chen Kui [Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China); Li Guangyou [Marine Bioactive Substances Laboratory, First Institute of Oceanography, SOA, Qingdao 266061 (China); Gaisano, Herbert Y. [Department of Medicine, University of Toronto, Toronto, M5S 1A8 (Canada)

    2006-04-07T23:59:59.000Z

    Vibrio anguillarum is a major pathogen threatening the fish aquaculture in China. Infection of cultivated turbot (Scophthalmus maximus) with V. anguillarum induced rapid synthesis and secretion of IL-1{beta}, which initiates the innate immune response. SNARE proteins are known to regulate vesicular trafficking and fusion in all eukaryotes. Here, we determined whether SNARE proteins, specifically vesicle-associated membrane protein-2 (VAMP-2), are involved in regulated exocytosis of IL-1{beta} of leukocytes in marine fish. We show that VAMP-2 is present in turbot blood leukocytes, with nucleotide sequence identity of 88.2% and 93.0% to those of zebra fish and sea bass, respectively. After Vibrio infection, turbot leukocyte VAMP-2 was increased at the levels of transcription and translation in a temporal pattern coinciding with leukocyte IL-1{beta} secretion. Confocal microscopy localized VAMP-2 to vesicle structures in leukocytes. Taken together, our results suggest that VAMP-2 is involved in regulated exocytosis of cytokines in immunocytes in fish.

  14. The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning

    SciTech Connect (OSTI)

    Wang Xinming [Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433 (China); Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031 (China); Gao Xiang [Laboratory of Molecular Cell Biology, Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031 (China); Zhang Xuehan [Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433 (China); Tu Yanyang [Laboratory of Molecular Cell Biology, Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031 (China); Jin Meilei [Research Center of Biotechnology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao-Bao Road, Shanghai 200233 (China); Zhao Guoping [Chinese National Human Genome Center at Shanghai, 351 Guo-Shou-Jing Road, Zhang-Jiang Hi-Tech Park, Shanghai 201203 (China); Yu Lei [Department of Genetics and Center of Alcohol Studies, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854 (United States); Jing Naihe [Laboratory of Molecular Cell Biology, Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031 (China); Li Baoming [Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433 (China)]. E-mail: bmli@fudan.edu.cn

    2006-02-24T23:59:59.000Z

    Tob (transducer of ErbB-2) is a negative cell cycle regulator with anti-proliferative activity in peripheral tissues. Our previous study identified Tob as a protein involved in hippocampus-dependent memory consolidation (M.L. Jin, X.M. Wang, Y.Y. Tu, X.H. Zhang, X. Gao, N. Guo, Z.Q. Xie, G.P. Zhao, N.H. Jing, B.M. Li, Y.Yu, The negative cell cycle regulator, Tob (Transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory, Neuroscience 131 (2005) 647-659). Here, we provide evidence that Tob in the central nervous system is engaged in acquisition of motor skill. Tob has a relatively high expression in the cerebellum. Tob expression is up-regulated in the cerebellum after rats receive training on a rotarod-running task. Rats infused with Tob antisense oligonucleotides into the 4th ventricle exhibit a severe deficit in running on a rotating rod or walking across a horizontally elevated beam.

  15. The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis

    SciTech Connect (OSTI)

    Noinaj, Nicholas; Bosserman, Mary A.; Schickli, M. Alexandra; Piszczek, Grzegorz; Kharel, Madan K.; Pahari, Pallab; Buchanan, Susan K.; Rohr, Jürgen (NIH); (Kentucky)

    2012-11-26T23:59:59.000Z

    GilR is a recently identified oxidoreductase that catalyzes the terminal step of gilvocarcin V biosynthesis and is a unique enzyme that establishes the lactone core of the polyketide-derived gilvocarcin chromophore. Gilvocarcin-type compounds form a small distinct family of anticancer agents that are involved in both photo-activated DNA-alkylation and histone H3 cross-linking. High resolution crystal structures of apoGilR and GilR in complex with its substrate pregilvocarcin V reveals that GilR belongs to the small group of a relatively new type of the vanillyl-alcohol oxidase flavoprotein family characterized by bicovalently tethered cofactors. GilR was found as a dimer, with the bicovalently attached FAD cofactor mediated through His-65 and Cys-125. Subsequent mutagenesis and functional assays indicate that Tyr-445 may be involved in reaction catalysis and in mediating the covalent attachment of FAD, whereas Tyr-448 serves as an essential residue initiating the catalysis by swinging away from the active site to accommodate binding of the 6R-configured substrate and consequently abstracting the proton of the hydroxyl residue of the substrate hemiacetal 6-OH group. These studies lay the groundwork for future enzyme engineering to broaden the substrate specificity of this bottleneck enzyme of the gilvocarcin biosynthetic pathway for the development of novel anti-cancer therapeutics.

  16. Exploring the Genome and Proteome of Desulfitobacterium hafniense DCB2 for its Protein Complexes Involved in Metal Reduction and Dechlorination

    SciTech Connect (OSTI)

    Kim, Sang-Hoon, Christina Harzman, John K. Davis, Rachel Hutcheson, Joan B. Broderick, Terence L. Marsh, James M. Tiedje.

    2012-09-27T23:59:59.000Z

    Desulfitobacteria are of interest to DOE mission because of their ability to reduce many electron acceptors including Fe(III), U(VI), Cr(VI), As(V), Mn(IV), Se(VI), NO3- and well as CO2, sulfite, fumarate and humates, their ability to colonize more stressful environments because they form spores, fix nitrogen and they have the more protective Gram positive cell walls. Furthermore at least some of them reductively dechlorinate aromatic and aliphatic pollutants. Importantly, most of the metals and the organochlorine reductions are coupled to ATP production and support growth providing for the organism's natural selection at DOE's contaminant sites. This work was undertaken to gain insight into the genetic and metabolic pathways involved in dissimilatory metal reduction and reductive dechlorination, (ii) to discern the commonalities among these electron-accepting processes, (iii) to identify multi-protein complexes catalyzing these functions and (iv) to elucidate the coordination in expression of these pathways and processes.

  17. DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

    SciTech Connect (OSTI)

    Tsujimoto, Y.; Bashir, M.M.; Givol, I.; Cossman, J.; Jaffe, E.; Croce, C.M.

    1987-03-01T23:59:59.000Z

    In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.

  18. DOE Technical Standards List. Directory of DOE and contractor personnel involved in non-government standards activities

    SciTech Connect (OSTI)

    NONE

    1997-06-01T23:59:59.000Z

    This is a periodic report on the level of agency participation in non-Government standards activities. This technical standards list is intended to assist US Department of Energy (DOE) management and other personnel involved in the DOE technical Standards Program by identifying those participating individuals. The body of this document contains a listing of DOE employees and DOE contractors who have submitted a Record of Non-Government Standards Activity. Additional names were added from rosters supplied by non-Government standards bodies. Appendices to this document are provided to list the information by parent employment organization, by non-Government standards activity, and by the proper names of the non-Government standards organizations and committees.

  19. Structural characterization of a family of cytochromes c{sub 7} involved in Fe(III) respiration by Geobacter sulfurreducens.

    SciTech Connect (OSTI)

    Pokkuluri, P. R.; Londer, Y. Y.; Yang, X.; Duke, N. E. C.; Erickson, J.; Orshonsky, V.; Johnson, G.; Schiffer, M.; Biosciences Division

    2010-02-01T23:59:59.000Z

    Periplasmic cytochromes c{sub 7} are important in electron transfer pathway(s) in Fe(III) respiration by Geobacter sulfurreducens. The genome of G. sulfurreducens encodes a family of five 10-kDa, three-heme cytochromes c{sub 7}. The sequence identity between the five proteins (designated PpcA, PpcB, PpcC, PpcD, and PpcE) varies between 45% and 77%. Here, we report the high-resolution structures of PpcC, PpcD, and PpcE determined by X-ray diffraction. This new information made it possible to compare the sequences and structures of the entire family. The triheme cores are largely conserved but are not identical. We observed changes, due to different crystal packing, in the relative positions of the hemes between two molecules in the crystal. The overall protein fold of the cytochromes is similar. The structure of PpcD differs most from that of the other homologs, which is not obvious from the sequence comparisons of the family. Interestingly, PpcD is the only cytochrome c{sub 7} within the family that has higher abundance when G. sulfurreducens is grown on insoluble Fe(III) oxide compared to ferric citrate. The structures have the highest degree of conservation around 'heme IV'; the protein surface around this heme is positively charged in all of the proteins, and therefore all cytochromes c{sub 7} could interact with similar molecules involving this region. The structures and surface characteristics of the proteins near the other two hemes, 'heme I' and 'heme III', differ within the family. The above observations suggest that each of the five cytochromes c{sub 7} could interact with its own redox partner via an interface involving the regions of heme I and/or heme III; this provides a possible rationalization for the existence of five similar proteins in G. sulfurreducens.

  20. The potential of plug-in hybrid electric vehicles to reduce petroleum use issues involved in developing reliable estimates.

    SciTech Connect (OSTI)

    Vyas, A. D.; Santini, D. J.; Johnson, L. R.; Energy Systems

    2009-01-01T23:59:59.000Z

    This paper delineates the various issues involved in developing reliable estimates of the petroleum use reduction that would result from the wide-spread introduction of plug-in hybrid electric vehicles (PHEVs). Travel day data from the 2001 National Household Travel Survey (NHTS) were analyzed to identify the share of vehicle miles of travel (VMT) that could be transferred to grid electricity. Various PHEV charge-depleting (CD) ranges were evaluated, and 100% CD mode and potential blended modes were analyzed. The NHTS data were also examined to evaluate the potential for PHEV battery charging multiple times a day. Data from the 2005 American Housing Survey (AHS) were analyzed to evaluate the availability of garages and carports for at-home charging of the PHEV battery. The AHS data were also reviewed by census region and household location within or outside metropolitan statistical areas. To illustrate the lag times involved, the historical new vehicle market share increases for the diesel power train in France (a highly successful case) and the emerging hybrid electric vehicles in the United States were examined. A new vehicle technology substitution model is applied to illustrate a historically plausible successful new PHEV market share expansion. The trends in U.S. light-duty vehicle sales and light-duty vehicle stock were evaluated to estimate the time required for hypothetical successful new PHEVs to achieve the ultimately attainable share of the existing vehicle stock. Only when such steps have been accomplished will the full oil savings potential for the nation be achieved.

  1. Accurate Computer Simulation of Phase Equilibrium for Complex Fluid Mixtures. Application to Binaries Involving Isobutene, Methanol, Methyl tert-Butyl Ether, and

    E-Print Network [OSTI]

    Lisal, Martin

    to Binaries Involving Isobutene, Methanol, Methyl tert-Butyl Ether, and n-Butane Martin Li´sal,*,, William R + methyl tert-butyl ether (MTBE) and the binaries formed by methanol with isobutene, MTBE, and n

  2. DOE Partnerships with States, Tribes and Other Federal Programs Help Responders Prepare for Challenges Involving Transport of Radioactive Materials

    SciTech Connect (OSTI)

    Marsha Keister

    2001-02-01T23:59:59.000Z

    DOE Partnerships with States, Tribes and Other Federal Programs Help Responders Prepare for Challenges Involving Transport of Radioactive Materials Implementing adequate institutional programs and validating preparedness for emergency response to radiological transportation incidents along or near U.S. Department of Energy (DOE) shipping corridors poses unique challenges to transportation operations management. Delayed or insufficient attention to State and Tribal preparedness needs may significantly impact the transportation operations schedule and budget. The DOE Transportation Emergency Preparedness Program (TEPP) has successfully used a cooperative planning process to develop strong partnerships with States, Tribes, Federal agencies and other national programs to support responder preparedness across the United States. DOE TEPP has found that building solid partnerships with key emergency response agencies ensures responders have access to the planning, training, technical expertise and assistance necessary to safely, efficiently and effectively respond to a radiological transportation accident. Through the efforts of TEPP over the past fifteen years, partnerships have resulted in States and Tribal Nations either using significant portions of the TEPP planning resources in their programs and/or adopting the Modular Emergency Response Radiological Transportation Training (MERRTT) program into their hazardous material training curriculums to prepare their fire departments, law enforcement, hazardous materials response teams, emergency management officials, public information officers and emergency medical technicians for responding to transportation incidents involving radioactive materials. In addition, through strong partnerships with Federal Agencies and other national programs TEPP provided technical expertise to support a variety of radiological response initiatives and assisted several programs with integration of the nationally recognized MERRTT program into other training venues, thus ensuring consistency of radiological response curriculums delivered to responders. This presentation will provide an overview of the steps to achieve coordination, to avoid redundancy, and to highlight several of the successful partnerships TEPP has formed with States, Tribes, Federal agencies and other national programs. Events, accident scenarios, and training where TEPP was proven to be integral in building the radiological response capabilities for first responders to actual radiological incidents are also highlighted. Participants will gain an appreciation for the collaborative efforts States and Tribes are engaging in with the DOE to ensure that responders all along the DOE transportation corridors are adequately prepared to respond to shipments of radioactive materials through their communities.

  3. Projecting Fatalities in Crashes Involving Older Drivers, 2000–2025, CRADA No. ORNL98-0500 Final Report

    SciTech Connect (OSTI)

    Hu, Patricia S. [ORNL] [ORNL; Jones, Donald W. [ORNL] [ORNL; Reuscher, Timothy [Oak Ridge Institute for Science and Education] [Oak Ridge Institute for Science and Education; Schmoyer, Richard S. [ORNL] [ORNL; Truett, Lorena F. [ORNL] [ORNL

    2000-04-01T23:59:59.000Z

    At the turn of the century – the 20th century that is – the median age in the United States was under 30 years; America was 60% rural in nature; and there were only 36 highway fatalities all year. As we leave the 20th century behind, the route into the 21st century is very different. “Intelligent” cars speed down multi-lane “smart” highways in a nation that is 75% urban. According to the Federal Highway Administration’s Highway Statistics, there are 28,000 times more vehicles on the road in 2000 than there were in 1900, and these vehicles travel about 2.6 trillion miles each year. Annual fatalities resulting from highway crashes have also increased – by over 1100%. We see other changes as well. The face of America is changing. It is growing older. In 2025, persons 65 and over will make up 18.5% of the total population. The number of persons aged 85 and over is increasing more rapidly than any other age group. More importantly, the elderly are taking more trips, driving further, and continuing to drive much later in life. These conditions lead to concerns about traffic safety. Although the elderly are healthier and drive safer cars than they did just two decades ago, their frailty makes them more susceptible to injury than younger persons involved in traffic crashes of the same severity. In addition, visual, physical, and cognitive skills, all of which contribute to driving abilities, decrease with advancing age. The familiar “U”-shaped curve depicting the rate of fatalities per vehicle miles traveled, shows that the elderly experience a higher highway fatality rate than any other age group except teenagers. While the overall number of highway fatalities has decreased regularly since 1972, the number of fatalities of elderly travelers has continued to increase steadily. This increase is cause for concern for both the elderly driver and for other persons on the roads who migh tbe placed in danger through crashes involving elderly drivers.

  4. Visible light stimulating dual-wavelength emission and O vacancy involved energy transfer behavior in luminescence for coaxial nanocable arrays

    SciTech Connect (OSTI)

    Yang, Lei, E-mail: nanoyang@qq.com [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Hunan Province Key Laboratory for Spray Deposition Technology and Application, Hunan University, Changsha 410082 (China); Dong, Jiazhang; Jiang, Zhongcheng [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Pan, Anlian; Zhuang, Xiujuan [Key Laboratory for Micro-Nano Physics and Technology of Hunan Province, Hunan University, Changsha 410082 (China)

    2014-06-14T23:59:59.000Z

    We report a strategy to investigate O vacancy (V{sub O}) involved energy transfer and dual-wavelength yellow emission in coaxial nanocable. By electric field deposition and subsequent sol-gel template approach, ZnO:Tb/Y{sub 2}O{sub 3}:Eu coaxial nanocable arrays are synthesized. After visible light excitation, system is promoted to O vacancy charge transfer state of V{sub O}(0/+). In the following cross relaxation, energy transfer from V{sub O} to the excitation energy level of Tb{sup 3+} in ZnO:Tb core area. While in Y{sub 2}O{sub 3}:Eu shell area, energy transfer to the excitation energy level of Eu{sup 3+}. Subsequently, dual-wavelength emission is observed. By constructing nanocable with dual-wavelength emission, yellow luminescence is obtained. Adjust doping concentration of Eu{sup 3+} or Tb{sup 3+} in the range of 0.01–0.05, chromaticity coordinates of ZnO:Tb/Y{sub 2}O{sub 3}:Eu nanocable stably stays at yellow region in color space except ZnO:Tb{sub 0.01}/Y{sub 2}O{sub 3}:Eu{sub 0.01}. As Vo states act as media in energy transfer process in nanocablers, visible light can stimulate dual-wavelength emissions. Yellow luminescent nanocable arrays will have great applications in light-emitting diode luminescence.

  5. Nuclear substructure reorganization during late stageerythropoiesis is selective and does not involve caspase cleavage ofmajor nuclear substructural proteins

    SciTech Connect (OSTI)

    Krauss, Sharon Wald; Lo, Annie J.; Short, Sarah A.; Koury, MarkJ.; Mohandas, Narla; Chasis, Joel Anne

    2005-04-06T23:59:59.000Z

    Enucleation, a rare feature of mammalian differentiation, occurs in three cell types: erythroblasts, lens epithelium and keratinocytes. Previous investigations suggest that caspase activation functions in lens epithelial and keratinocyte enucleation, as well as in early erythropoiesis encompassing BFU-E differentiation to proerythroblast. To determine whether caspase activation contributes to later erythropoiesis and whether nuclear substructures other than chromatin reorganize, we analyzed distributions of nuclear subcompartment proteins and assayed for caspase-induced cleavage of subcompartmental target proteins in mouse erythroblasts. We found that patterns of lamin B in the filamentous network interacting with both the nuclear envelope and DNA, nuclear matrix protein NuMA, and splicing factors Sm and SC35 persisted during nuclear condensation, consistent with effective transcription of genes expressed late in differentiation. Thus nuclear reorganization prior to enucleation is selective, allowing maintenance of critical transcriptional processes independent of extensive chromosomal reorganization. Consistent with these data, we found no evidence for caspase-induced cleavage of major nuclear subcompartment proteins during late erythropoiesis, in contrast to what has been observed in early erythropoiesis and in lens epithelial and keratinocyte differentiation. These findings imply that nuclear condensation and extrusion during terminal erythroid differentiation involve novel mechanisms that do not entail major activation of apoptotic machinery.

  6. G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis

    SciTech Connect (OSTI)

    Shi, Yanan; Liu, Xiaochun [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China)] [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China); Zhu, Pei; Li, Jianzhen; Sham, Kathy W.Y. [School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China)] [School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China); Cheng, Shuk Han [Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (China)] [Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (China); Li, Shuisheng; Zhang, Yong [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China)] [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China); Cheng, Christopher H.K., E-mail: chkcheng@cuhk.edu.hk [School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China); Lin, Haoran, E-mail: lsslhr@mail.sysu.edu.cn [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China) [State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275 (China); College of Ocean, Hainan University, Haikou 570228, Hainan (China)

    2013-05-24T23:59:59.000Z

    Highlights: •The Gper expression was detected in the developing brain of zebrafish. •Gper morpholino knockdown induced apoptosis of brain cells. •Gper morpholino knockdown reduced expression in neuron markers. •Zebrafish Gper may be involved in neuronal development. -- Abstract: G-protein-coupled estrogen receptor 1 (Gper, formerly known as GPR30) is found to be a trophic and protective factor in mediating action of estrogen in adult brain, while its role in developing brain remains to be elucidated. Here we present the expression pattern of Gper and its functions during embryogenesis in zebrafish. Both the mRNA and protein of Gper were detected throughout embryogenesis. Whole mount in situ hybridization (WISH) revealed a wide distribution of gper mRNAs in various regions of the developing brain. Gper knockdown by specific morpholinos resulted in growth retardation in embryos and morphological defects in the developing brain. In addition, induced apoptosis, decreased proliferation of the brain cells and maldevelopment of sensory and motor neurons were also found in the morphants. Our results provide novel insights into Gper functions in the developing brain, revealing that Gper can maintain the survival of the brain cells, and formation and/or differentiation of the sensory and motor neurons.

  7. A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts

    SciTech Connect (OSTI)

    Jeon, Sang-Min [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Choi, Bongkun [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Hong, Kyung Uk [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Kim, Eunhee [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Seong, Yeon-Sun [Department of Biochemistry, Dankook University College of Medicine, Chunan (Korea, Republic of); Bae, Chang-Dae [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Park, Joobae [Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of)]. E-mail: jbpark@med.skku.ac.kr

    2006-09-15T23:59:59.000Z

    Previously, we reported the cloning of a cytoskeleton-associated protein, TMAP/CKAP2, which was up-regulated in primary human gastric cancers. Although TMAP/CKAP2 has been found to be expressed in most cancer cell lines examined, the function of CKAP2 is not known. In this study, we found that TMAP/CKAP2 was not expressed in G0/G1 arrested HFFs, but that it was expressed in actively dividing cells. After initiating the cell cycle, TMAP/CKAP2 levels remained low throughout most of the G1 phase, but gradually increased between late G1 and G2/M. Knockdown of TMAP/CKAP2 reduced pRB phosphorylation and increased p27 expression, and consequently reduced HFF proliferation, whereas constitutive TMAP/CKAP2 expression increased pRB phosphorylation and enhanced proliferation. Our results show that this novel cytoskeleton-associated protein is expressed cell cycle dependently and that it is involved in cell proliferation.

  8. Conformation Changes N-terminal Involvement and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

    SciTech Connect (OSTI)

    H Wang; H Robinson; H Ke

    2011-12-31T23:59:59.000Z

    The activity of phosphodiesterase-5 (PDE5) is specific for cGMP and is regulated by cGMP binding to GAF-A in its regulatory domain. To better understand the regulatory mechanism, x-ray crystallographic and biochemical studies were performed on constructs of human PDE5A1 containing the N-terminal phosphorylation segment, GAF-A, and GAF-B. Superposition of this unliganded GAF-A with the previously reported NMR structure of cGMP-bound PDE5 revealed dramatic conformational differences and suggested that helix H4 and strand B3 probably serve as two lids to gate the cGMP-binding pocket in GAF-A. The structure also identified an interfacial region among GAF-A, GAF-B, and the N-terminal loop, which may serve as a relay of the cGMP signal from GAF-A to GAF-B. N-terminal loop 98-147 was physically associated with GAF-B domains of the dimer. Biochemical analyses showed an inhibitory effect of this loop on cGMP binding and its involvement in the cGMP-induced conformation changes.

  9. Molecular cloning and sequence of the thdF gene involved in the thiophene and furan oxidation by Escherichia coli

    SciTech Connect (OSTI)

    Alam, K.Y.; Clark, D.P.

    1990-01-01T23:59:59.000Z

    Since sulfur dioxide emission from burning high sulfur coals is a major contributor to acid rain, it is important to develop bacteria which are capable of efficiently removing the sulfur from coal before combustion. Inorganic sulfur can be removed from coal by certain strains of Thiobacillus or Sulfolobus; however the organic sulfur remains intransigent. Since high sulfur Illinois coals typically contain 60% to 70% of their sulfur in the form of the heterocyclic thiophene ring we have started to investigate the biodegradation of derivatives of thiophene and the corresponding oxygen heterocycle, furan. Our previous work resulted in the isolation of a triple mutant, NAR30, capable of oxidizing a range of furan and thiophene derivatives. However, NAR30 does not completely degrade thiophenes or furans and its oxidation of these compounds is slow and inefficient. We decided to clone the thd genes both in order to increase the efficiency of degradation and to investigate the nature of the reactions involved. 37 refs., 4 figs., 3 tabs.

  10. Reaction mechanisms in aromatic hydrocarbon formation involving the C{sub 5}H{sub 5} cyclopentadienyl moiety

    SciTech Connect (OSTI)

    Melius, C.F.; Colvin, M.E. [Sandia National Labs., Livermore, CA (United States); Marinov, N.M.; Pitz, W.J. [Lawrence Livermore National Lab., CA (United States); Senkan, S.M. [Univ. of California, Los Angeles, CA (United States). Dept. of Chemical Engineering

    1996-02-01T23:59:59.000Z

    The quantum chemical BAC-MP4 and BAC-MP2 methods have been used to investigate the reaction mechanisms leading to polycyclic aromatic hydrocarbon (PAH) ring formation. In particular the authors have determined the elementary reaction steps in the conversion of two cyclopentadienyl radicals to naphthalene. This reaction mechanism is shown to be an extension of the mechanism occurring in the H atom-assisted conversion of fulvene to benzene. The net reaction involves the formation of dihydrofulvalene, which eliminates a hydrogen atom and then rearranges to form naphthalene through a series of ring closures and openings. The importance of forming the {single_bond}CR({center_dot}){single_bond}CHR{single_bond}CR{prime}{double_bond}CR{double_prime}-moiety, which can undergo rearrangement to form three-carbon-atom ring structures, is illustrated with the C{sub 4}H{sub 7} system. The ability of hydrogen atoms to migrate around the cyclopentadienyl moiety is illustrated both for methyl-cyclopentadiene, C{sub 5}H{sub 5}CH{sub 3}, and dihydrofulvalene, C{sub 5}H{sub 5}C{sub 5}H{sub 5}, as well as for their radical species, C{sub 6}H{sub 7} and C{sub 5}H{sub 5}C{sub 5}H{sub 4}. The mobility of hydrogen in the cyclopentadienyl moiety plays an important role both in providing resonance-stabilized radical products and in creating the {single_bond}CR({center_dot}){single_bond}CHR{single_bond}CR{prime}{double_bond}CR{double_prime}-moiety for ring formation. The results illustrate the radical pathway for converting five-membered rings to aromatic six-membered rings. Furthermore, the results indicate the important catalytic role of H atoms in the aromatic ring formation process.

  11. Botryllus schlosseri (Tunicata) whole colony irradiation: Do senescent zooid resorption and immunological resorption involve similar recognition events

    SciTech Connect (OSTI)

    Rinkevich, B.; Weissman, I.L. (Israel Oceanographic and Limnological Research, Haifa (Israel))

    1990-02-01T23:59:59.000Z

    The colonial tunicate Botryllus schlosseri undergoes cyclic blastogenesis where feeding zooids are senescened and resorbed and a new generation of zooids takes over the colony. When non-identical colonies come into direct contact, they either reject each other or fuse. Fusion is usually followed by the resorption of one of the partners in the chimera (immunological resorption). The striking morphological similarities between the two resorption phenomena suggest that both may involve tissue destruction following self-nonself recognition events. Here we attempt to modify these two events by whole colony gamma irradiation assays. Three sets of experiments were performed: (1) different doses of whole colony irradiation for determination of irradiation effects (110 colonies); (2) pairs of irradiated-nonirradiated isografts of clonal replicates for the potential of reconstruction of the irradiated partners (23 pairs); (3) chimeras of irradiated-nonirradiated partners for analysis of resorption hierarchy. Mortality increased with the irradiation dose. All colonies exposed to more than 5,000 rads died within 19 days, while no colony died below 2,000 rads. The average mortality periods, in days, for doses of 6,000-8,000, 5,000, and 2,500-4,000 rads were 14.4 +/- 3.1 (n = 24), 19.8 +/- 6.0 (n = 15), and 19.6 + 5.1 (n = 22), respectively. Younger colonies (3-6 months old) may survive radiation better than older ones (more than 13 months). Many morphological alterations were recorded in irradiated colonies: ampullar contraction and/or dilation, accumulation of pigment cells within ampullae, abnormal bleeding from blood vessels, sluggish blood circulation, necrotic zones, reduction in bud number, and irregularities in zooid and system structures. With doses of 3,000-4,000 rads and above, irradiation arrested the formation of new buds and interrupted normal takeover.

  12. Technical advantages and political necessity of public involvement in environmental remediation: The case of the U.S. and Russian weapons complexes

    SciTech Connect (OSTI)

    Shideler, J.C. [JK Research Associates, Inc., Arlington, VA (United States)

    1993-12-31T23:59:59.000Z

    Environmental remediation is an enormous challenge for the governments of the US, Russia, and other states in eastern and central Europe. Historically, governments have withheld issues related to nuclear weapons from public policy debate. As a result of revelations about human health impacts and environmental contamination, serious credibility problems exist for managers of weapons facilities. However, public involvement can contribute to better definition of problems, to identification of a range of potential solutions, and to increased public acceptance of outcomes. Decision makers can maximize the benefits of public involvement by integrating specific processes into their environmental remediation project planning and management.

  13. FACT SHEET: Projects with the Federal Emergency Management Agency (FEMA) CCICADA is involved in several projects in partnership with FEMA Region II (which covers NJ, NY, Puerto Rico, and the

    E-Print Network [OSTI]

    is involved in several projects in partnership with FEMA Region II (which covers NJ, NY, Puerto Rico

  14. Center for Leadership and Involvement University of Wisconsin-Madison 239 Red Gym, 716 Langdon Street Phone: 608-263-0365

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    involvement as an integral part of a University education, registers over 750 student organizations, and provides services, information, education, support, advising, and interpretation of university policies evaluations are submitted. Maintain and track the grant's budget. Provide budget updates at Review Committee

  15. CONCLUSIONS AND RECOMMENDATIONS This report summarizes the findings of a four-year research effort involving more than 4,000

    E-Print Network [OSTI]

    -year research effort involving more than 4,000 wind turbines, and aimed at better understanding bird mortality at the world's largest wind farm, the Altamont Pass Wind Resource Area. Yet, as with most research efforts, we finished with many questions remaining unanswered about the factors associated with fatalities at wind

  16. How to connect to the University of Exeter VPN service *****Important Part of the process of using the VPN service involves the automatic

    E-Print Network [OSTI]

    Mumby, Peter J.

    the VPN service involves the automatic download and installation of Juniper Network Connect software administrator rights on your computer to be able to install this software. Once this has been installed you can use it regardless of having administrator rights or not. Additionally, you can check the last page

  17. What does it take to earn a BS degree in Electrical Engineering? A BS degree in Electrical Engineering is earned through a 4-year program involving a fundamental

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    What does it take to earn a BS degree in Electrical Engineering? A BS degree in Electrical Engineering is earned through a 4-year program involving a fundamental understanding of electrical and electronic circuits and systems. Electrical engineers get to work with microscopic circuit components

  18. The naval Research Laboratory has been actively involved in research in unmanned and autonomous systems since its opening in 1923. From one of the first unmanned

    E-Print Network [OSTI]

    systems since its opening in 1923. From one of the first unmanned ground vehicles to the developmentThe naval Research Laboratory has been actively involved in research in unmanned and autonomous of more than 200 prototype air, ground, underwater, and space platforms, and from smart sensors to smart

  19. Value of Citizen Science Monitoring Involving citizen scientists in the sea star wasting disease survey effort will greatly expand our spatial

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    Value of Citizen Science Monitoring Involving citizen scientists in the sea star wasting disease survey effort will greatly expand our spatial and temporal coverage. Citizen science groups can collect. A researcher from the MARINe group should accompany each citizen science group in the field to assist

  20. LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9

    E-Print Network [OSTI]

    Lee, Won-Ha

    LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro inflammation and cartilage destruction.7­9 LIGHT (TNFSF14) is a member of tumor necrosis factor superfamily and is the ligand for TR2 (TNFRSF14/HVEM/ HveA/LIGHTR/ATAR) and lymphotoxin (LT)-b.10­12 LIGHT is known

  1. In Vitro Drug Sensitivity-Gene Expression Correlations Involve a Tissue of Origin C. R. Andersson, M. Fryknas, L. Rickardson, R. Larsson, A. Isaksson, and

    E-Print Network [OSTI]

    In Vitro Drug Sensitivity-Gene Expression Correlations Involve a Tissue of Origin Dependency C. R concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles

  2. Andreja Sarlah Research interests I have been involved in physical research for 4 years now. In that time I have been work-

    E-Print Network [OSTI]

    Sarlah, Andreja

    . In that time I have been work- ing in the field of liquid crystals. My main research interest has been. This is what in my opinion makes the research work interesting and what gives the assuranceAndreja Sarlah ­ Research interests I have been involved in physical research for 4 years now

  3. Lynne Ellyn is the senior vice president and chief information officer at DTE Energy (NYSE: DTE), a Detroit-based diversified energy company involved in the development and

    E-Print Network [OSTI]

    Health System Foundation, the Henry Ford Health System Quality Committee, and the DTE Energy Charitable: DTE), a Detroit-based diversified energy company involved in the development and management of energy of Management in Information Technology Advisory Board. She serves on the board of trustees of the Henry Ford

  4. Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-­lysosome fusion

    E-Print Network [OSTI]

    Brandstaetter, Hemma; Kishi-­Itakura, Chieko; Tumbarello, David A.; Manstein, Dietmar J.; Buss, Folma

    2015-01-28T23:59:59.000Z

    trafficking, disrupts autophagosome-lysosome fusion Hemma Brandstaetter a , Chieko Kishi-Itakura a , David A Tumbarello ac , Dietmar J Manstein b & Folma Buss a a Cambridge Institute for Medical Research; University of Cambridge; Cambridge, UK b Institute... this article: Hemma Brandstaetter, Chieko Kishi-Itakura, David A Tumbarello, Dietmar J Manstein & Folma Buss (2014) Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion, Autophagy, 10...

  5. Involvement of the endogenous opioid peptides in luteinizing hormone-releasing hormone release in vitro during the breeding and non-breeding season in the mature ewe

    E-Print Network [OSTI]

    Wu, Tao-Yiao Johnny

    1988-01-01T23:59:59.000Z

    ovulation (Packman and Rothchild, 1976; Pang et al. , 1977). When NAL was infused The citations in the following pages follow the style of i j)-endorphin (Leu)-enkephalin (Met)-enkephalin -Met-Thr-Ser-Glu-Lys-Ser-Gin-Thr- Pro-Leu-Vat-Thr... of gonadotropin release was blocked by NAL. This suggests the involvement of opioid receptors in gonadotropin secretion (Packman and Rothchild, 1976). Pang et al. (1977) showed that LHRH administration overcame the morphine inhibitory effect, suggesting...

  6. Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus

    SciTech Connect (OSTI)

    Banerjee, Chaitali [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Goswami, Ramansu [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Centre for Environmental Studies, Visva-Bharati University, Santiniketan 731 235 (India); Datta, Soma [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Rajagopal, R. [Gut Biology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Mazumder, Shibnath, E-mail: shibnath1@yahoo.co.in [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India)

    2011-10-01T23:59:59.000Z

    We had earlier shown that exposure to arsenic (0.50 {mu}M) caused caspase-3 mediated head kidney macrophage (HKM) apoptosis involving the p38-JNK pathway in Clarias batrachus. Here we examined the roles of calcium (Ca{sup 2+}) and extra-cellular signal-regulated protein kinase (ERK), the other member of MAPK-pathway on arsenic-induced HKM apoptosis. Arsenic-induced HKM apoptosis involved increased expression of ERK and calpain-2. Nifedipine, verapamil and EGTA pre-treatment inhibited the activation of calpain-2, ERK and reduced arsenic-induced HKM apoptosis as evidenced from reduced caspase-3 activity, Annexin V-FITC-propidium iodide and Hoechst 33342 staining. Pre-incubation with ERK inhibitor U 0126 inhibited the activation of calpain-2 and interfered with arsenic-induced HKM apoptosis. Additionally, pre-incubation with calpain-2 inhibitor also interfered with the activation of ERK and inhibited arsenic-induced HKM apoptosis. The NADPH oxidase inhibitor apocynin and diphenyleneiodonium chloride also inhibited ERK activation indicating activation of ERK in arsenic-exposed HKM also depends on signals from NADPH oxidase pathway. Our study demonstrates the critical role of Ca{sup 2+} homeostasis on arsenic-induced HKM apoptosis. We suggest that arsenic-induced alteration in intracellular Ca{sup 2+} levels initiates pro-apoptotic ERK and calpain-2; the two pathways influence each other positively and induce caspase-3 mediated HKM apoptosis. Besides, our study also indicates the role of ROS in the activation of ERK pathway in arsenic-induced HKM apoptosis in C. batrachus. - Highlights: > Altered Ca{sup 2+} homeostasis leads to arsenic-induced HKM apoptosis. > Calpain-2 plays a critical role in the process. > ERK is pro-apoptotic in arsenic-induced HKM apoptosis. > Arsenic-induced HKM apoptosis involves cross talk between calpain-2 and ERK.

  7. A stakeholder involvement approach to evaluate and enhance technology acceptance: U.S. Department of Energy Office of Technology Development`s Plume Focus Area

    SciTech Connect (OSTI)

    McCabe, G.H. [Battelle Seattle Research Center, WA (United States); Stein, S.L. [Battelle Pacific Northwest Division, Richland, WA (United States); Serie, P.J. [Environmental Issues Management, Inc., Seattle, WA (United States)

    1995-12-31T23:59:59.000Z

    The US Department of Energy (DOE) faces a major challenge in cleaning up its contaminated sites throughout the United States. One major area of concern is the plumes in soil and ground water which are contaminated with a myriad of different pollutants. DOE recently organized its plume-related problems into the Plume Focus Area. The mission of the Plume Focus Area is to enhance the deployment of innovative technologies for containing and cleaning up contaminant plumes in ground water and soil at all DOE sites. Environmental cleanup priorities for soil and ground water plumes are being defined and technology users have the challenge of matching current and innovative technologies to those priorities. By involving a range of stakeholders in the selection, demonstration, and evaluation of new technologies, the deployment of these technologies can be enhanced. If new plume cleanup technologies are to be deployable, they must improve on today`s baseline technologies. The Sites` Coordination Team (SCT) of the Plume Focus Area develops and supports the implementation of methods for stakeholder involvement throughout the multiple steps that define focus area activities. Site-specific teams are being formed to carry out the strategy at each site, and the teams will work through Site Technology Coordination Groups (STCGs) at each location. The SCT is responsible for identifying the site-specific stakeholder involvement teams, training the team members, preparing needed national-level guidance and strategies, helping the teams tailor a strategy for their particular site that meets the overall needs of the focus area, and facilitating inter-site coordination. The results will be used to develop national technology acceptance reports on the innovative technologies being funded and evaluated under the Plume Focus Area.

  8. Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface

    E-Print Network [OSTI]

    Lonez, Caroline; Irvine, Kate L.; Pizzuto, Malvina; Schmidt, Boris I.; Gay, Nick J.; Ruysschaert, Jean-Marie; Gangloff, Monique; Bryant, Clare E.

    2015-05-09T23:59:59.000Z

    gradient of 19 0.05 kcal/mol and a maximum of 100 cycles of iteration. Partial charges were computed based on the 20 Gasteiger-Hückel charge method. 21 TLR4 and MD-2 templates. The molecular structures of the extracellular region of human TLR4 on its 22... conserved domain involved in innate immunity and lipid 1 metabolism. Trends Biochem. Sci. 27: 219-221. doi: 10.1016/S0968-0004(02)02084-4 2 33. Dundas,J, Ouyang,Z, Tseng,J, Binkowski,A, Turpaz,Y, Liang,J (2006). CASTp: computed 3 atlas of surface...

  9. Rate Adjustments and Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CRSP Transmission 9162013 WAPA-161 FRN, CRSP transmission and ancillary services rates extension Letter announcing two-year extension to CRSP transmission and ancillary...

  10. Classified Visits Involving Foreign Nationals

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-01-13T23:59:59.000Z

    The Order establishes a program to manage the Department-wide program to facilitate, document, and assure accountability when approving foreign national access to classified DOE programs and facilities. Cancels portions of Chapter VIII, of DOE O 470.1 that pertain to foreign nationals who visit DOE sitess and require access to classified information. Canceled by DOE O 470.4B.

  11. Cyber Incidents Involving Control Systems

    SciTech Connect (OSTI)

    Robert J. Turk

    2005-10-01T23:59:59.000Z

    The Analysis Function of the US-CERT Control Systems Security Center (CSSC) at the Idaho National Laboratory (INL) has prepared this report to document cyber security incidents for use by the CSSC. The description and analysis of incidents reported herein support three CSSC tasks: establishing a business case; increasing security awareness and private and corporate participation related to enhanced cyber security of control systems; and providing informational material to support model development and prioritize activities for CSSC. The stated mission of CSSC is to reduce vulnerability of critical infrastructure to cyber attack on control systems. As stated in the Incident Management Tool Requirements (August 2005) ''Vulnerability reduction is promoted by risk analysis that tracks actual risk, emphasizes high risk, determines risk reduction as a function of countermeasures, tracks increase of risk due to external influence, and measures success of the vulnerability reduction program''. Process control and Supervisory Control and Data Acquisition (SCADA) systems, with their reliance on proprietary networks and hardware, have long been considered immune to the network attacks that have wreaked so much havoc on corporate information systems. New research indicates this confidence is misplaced--the move to open standards such as Ethernet, Transmission Control Protocol/Internet Protocol, and Web technologies is allowing hackers to take advantage of the control industry's unawareness. Much of the available information about cyber incidents represents a characterization as opposed to an analysis of events. The lack of good analyses reflects an overall weakness in reporting requirements as well as the fact that to date there have been very few serious cyber attacks on control systems. Most companies prefer not to share cyber attack incident data because of potential financial repercussions. Uniform reporting requirements will do much to make this information available to Department of Homeland Security (DHS) and others who require it. This report summarizes the rise in frequency of cyber attacks, describes the perpetrators, and identifies the means of attack. This type of analysis, when used in conjunction with vulnerability analyses, can be used to support a proactive approach to prevent cyber attacks. CSSC will use this document to evolve a standardized approach to incident reporting and analysis. This document will be updated as needed to record additional event analyses and insights regarding incident reporting. This report represents 120 cyber security incidents documented in a number of sources, including: the British Columbia Institute of Technology (BCIT) Industrial Security Incident Database, the 2003 CSI/FBI Computer Crime and Security Survey, the KEMA, Inc., Database, Lawrence Livermore National Laboratory, the Energy Incident Database, the INL Cyber Incident Database, and other open-source data. The National Memorial Institute for the Prevention of Terrorism (MIPT) database was also interrogated but, interestingly, failed to yield any cyber attack incidents. The results of this evaluation indicate that historical evidence provides insight into control system related incidents or failures; however, that the limited available information provides little support to future risk estimates. The documented case history shows that activity has increased significantly since 1988. The majority of incidents come from the Internet by way of opportunistic viruses, Trojans, and worms, but a surprisingly large number are directed acts of sabotage. A substantial number of confirmed, unconfirmed, and potential events that directly or potentially impact control systems worldwide are also identified. Twelve selected cyber incidents are presented at the end of this report as examples of the documented case studies (see Appendix B).

  12. Safety Success Through Employee Involvement

    Broader source: Energy.gov [DOE]

    Presenters: James Pollard, Monica Lewis, Michael Hendrix, Stacy Miller, Y-12 National Security Complex Track 2-2

  13. Who's Involved | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradley NickellApril 16, 2008 TBD-0075 -In the Matter 1Who are2014

  14. Procurement Services Involvement with Contracts

    E-Print Network [OSTI]

    Huang, Jianyu

    Diligence and/or pre-qualification information to make sure vendors are a viable source. (Alumnus, disadvantaged vendor programs, etc.) · Facilitation Services, sustainability information on equipment

  15. Appendix V Public Involvement Plan

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7111A Lithologic and Monitor Well CompletionV

  16. HOW YOU CAN BE INVOLVED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.NewofGeothermal HeatonHEP/NERSC/ASCRJuneSave84047HNUtHUl IHOW

  17. Public Involvment Plan - Rifle, Colorado

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City, Arizona,Site Operations Guide Doc. No.GS05:orPOST-REMEDIAL4-TAR

  18. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET J.-L.Pseudogaps,PuPublic Comment

  19. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET J.-L.Pseudogaps,PuPublic

  20. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET J.-L.Pseudogaps,PuPublicSeptember

  1. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    SciTech Connect (OSTI)

    Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

    2008-06-06T23:59:59.000Z

    Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

  2. Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: Involvement of acylpeptide hydrolase and {alpha}{sub 7} nicotinic receptors

    SciTech Connect (OSTI)

    Olmos, Cristina; Sandoval, Rodrigo [Laboratory of Environmental Neurotoxicology, Department of Biomedical Sciences, Faculty of Medicine, Universidad Catolica del Norte, Larrondo 1281, 178-1421 Coquimbo (Chile); Rozas, Carlos [Laboratory of Neurosciences, Department of Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Alameda 3363, Santiago (Chile); Navarro, Sebastian [Laboratory of Environmental Neurotoxicology, Department of Biomedical Sciences, Faculty of Medicine, Universidad Catolica del Norte, Larrondo 1281, 178-1421 Coquimbo (Chile); Wyneken, Ursula [Laboratory of Neurosciences, Faculty of Medicine, Universidad de Los Andes, San Carlos de Apoquindo 2200, Santiago (Chile); Zeise, Marc [School of Psychology, Faculty of Humanities, University of Santiago de Chile, Alameda 3363, Santiago (Chile); Morales, Bernardo [Laboratory of Neurosciences, Department of Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Alameda 3363, Santiago (Chile); Pancetti, Floria [Laboratory of Environmental Neurotoxicology, Department of Biomedical Sciences, Faculty of Medicine, Universidad Catolica del Norte, Larrondo 1281, 178-1421 Coquimbo (Chile)], E-mail: pancetti@ucn.cl

    2009-07-01T23:59:59.000Z

    Dichlorvos is the active molecule of the pro-drug metrifonate used to revert the cognitive deficits associated with Alzheimer's disease. A few years ago it was reported that dichlorvos inhibits the enzyme acylpeptide hydrolase at lower doses than those necessary to inhibit acetylcholinesterase to the same extent. Therefore, the aim of our investigation was to test the hypothesis that dichlorvos can enhance synaptic efficacy through a mechanism that involves acylpeptide hydrolase instead of acetylcholinesterase inhibition. We used long-term potentiation induced in rat hippocampal slices as a model of synaptic plasticity. Our results indicate that short-term exposures (20 min) to 50 {mu}M dichlorvos enhance long-term potentiation in about 200% compared to the control condition. This effect is correlated with approximately 60% inhibition of acylpeptide hydrolase activity, whereas acetylcholinesterase activity remains unaffected. Paired-pulse facilitation and inhibition experiments indicate that dichlorvos does not have any presynaptic effect in the CA3 {yields} CA1 pathway nor affect gabaergic interneurons. Interestingly, the application of 100 nM methyllicaconitine, an {alpha}{sub 7} nicotinic receptor antagonist, blocked the enhancing effect of dichlorvos on long-term potentiation. These results indicate that under the exposure conditions described above, dichlorvos enhances long-term potentiation through a postsynaptic mechanism that involves (a) the inhibition of the enzyme acylpeptide hydrolase and (b) the modulation of {alpha}{sub 7} nicotinic receptors.

  3. Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation

    SciTech Connect (OSTI)

    Fu, Na; Su, Dian; Cort, John R.; Chen, Baowei; Xiong, Yijia; Qian, Weijun; Konopka, Allan; Bigelow, Diana J.; Squier, Thomas C.

    2013-03-06T23:59:59.000Z

    Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic pathways in response to changing environmental conditions. To enable in vivo measurements of cellular redox changes linked to disulfide bond formation, we have synthesized a cell-permeable monosubstituted cyanine dye derivatized with arsenic (i.e., TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins. Alkylation of reactive thiols prior to displacement of the bound TRAP-Cy3 by ethanedithiol permits facile protein capture and mass spectrometric identification of proximal reduced dithiols to the exclusion of individual cysteines. Applying TRAP_Cy3 to evaluate cellular responses to increases in oxygen and light levels in the photosynthetic microbe Synechococcus sp. PCC 7002, we observe large decreases in the abundance of reduced dithiols in cellular proteins, which suggest redox-dependent mechanisms involving the oxidation of proximal disulfides. Under these same growth conditions that result in the oxidation of proximal thiols, there is a reduction in the abundance of post-translational oxidative modifications involving nitrotyrosine and methionine sulfoxide formation. These results suggest that the redox status of proximal cysteines respond to environmental conditions, acting to regulate metabolic flux and minimize the formation of reactive oxygen species to decrease oxidative protein damage.

  4. The Bond Between CO and Cp?3U in Cp?3U(CO) involves Backbonding from the Cp'3U Ligand-based Orbitals of ?pi-Symmetry, where Cp' Represents a Substituted Cyclopentadienyl Ligand.

    E-Print Network [OSTI]

    Maron, Laurent

    2010-01-01T23:59:59.000Z

    backbonding from Cp’ 3 U to CO involves electrons in the U-the d ? and f ? -parentage. TOC f ? f ? f ? /d ? Cp 3 U COThe Bond Between CO and Cp’ 3 U in Cp’ 3 U(CO) involves

  5. In the first trial involving 86 piglets per treatment, diets containing 18 and 20 p. 100 crude protein, with and without fish meal, were used. The weight and mean age of the piglets

    E-Print Network [OSTI]

    Boyer, Edmond

    - In the first trial involving 86 piglets per treatment, diets containing 18 and 20 p. 100 crude trial involving 144 piglets per treatment, a diet including 20 p. 100 crude protein with and without /piglet. The results of the two trials show that for a given crude protein level, the addition of fish

  6. Can biophysics tell us something about the weak equivalence principle vis a vis the thought experiment of Einstein involving human subjects?

    E-Print Network [OSTI]

    Fred H. Thaheld

    2009-06-16T23:59:59.000Z

    Over a period of several decades it has been noticed that most astronauts, either orbiting the earth or on trips to the moon, have observed phosphenes or light flashes (LF) including streaks, spots and clouds of light when their eyes are closed or they are in a darkened cabin. Scientists suspect that two separate components of cosmic rays cause these flashes due to direct interaction with the retina. This phenomenon is not noticed on the ground because of cosmic ray interaction with the atmosphere. The argument is advanced that this effect may provide us with a new method of exploring the weak equivalence principle from the standpoint of Einstein's original thought experiment involving human subjects. This can be done, utilizing the retina only, as an animate quantum mechanical measuring device or, in conjunction with the Anomalous Long Term Effects on Astronauts (ALTEA) facility.

  7. Derivation of the Blackbody Radiation Spectrum from a Natural Maximum-Entropy Principle Involving Casimir Energies and Zero-Point Radiation

    E-Print Network [OSTI]

    Timothy H. Boyer

    2002-10-30T23:59:59.000Z

    By numerical calculation, the Planck spectrum with zero-point radiation is shown to satisfy a natural maximum-entropy principle whereas alternative choices of spectra do not. Specifically, if we consider a set of conducting-walled boxes, each with a partition placed at a different location in the box, so that across the collection of boxes the partitions are uniformly spaced across the volume, then the Planck spectrum correspond to that spectrum of random radiation (having constant energy kT per normal mode at low frequencies and zero-point energy (1/2)hw per normal mode at high frequencies) which gives maximum uniformity across the collection of boxes for the radiation energy per box. The analysis involves Casimir energies and zero-point radiation which do not usually appear in thermodynamic analyses. For simplicity, the analysis is presented for waves in one space dimension.

  8. Dosimetric Comparison of Involved-Field Three-Dimensional Conformal Photon Radiotherapy and Breast-Sparing Proton Therapy for the Treatment of Hodgkin's Lymphoma in Female Pediatric Patients

    SciTech Connect (OSTI)

    Andolino, David L., E-mail: dandolin@iupui.edu [Department of Radiation Oncology, Indiana University School of Medicine, Bloomington, IN (United States); Hoene, Ted [Midwest Proton Radiotherapy Institute, Bloomington, IN (United States); Xiao, Lu [Department of Radiation Oncology, Indiana University School of Medicine, Bloomington, IN (United States); Buchsbaum, Jeffrey; Chang, Andrew L. [Department of Radiation Oncology, Indiana University School of Medicine, Bloomington, IN (United States); Midwest Proton Radiotherapy Institute, Bloomington, IN (United States)

    2011-11-15T23:59:59.000Z

    Purpose: To assess the potential reduction in breast dose for young girls with Hodgkin's lymphoma (HL) treated with breast-sparing proton therapy (BS-PT) as compared with three-dimensional conformal involved-field photon radiotherapy (3D-CRT). Methods and Materials: The Clarian Health Cancer Registry was queried for female pediatric patients with the diagnosis of HL who received radiotherapy at the Indiana University Simon Cancer Center during 2006-2009. The original CT simulation images were obtained, and 3D-CRT and BS-PT plans delivering 21 Gy or cobalt gray equivalent (CGE) in 14 fractions were created for each patient. Dose-volume histogram data were collected for both 3D-CRT and BS-PT plans and compared by paired t test for correlated samples. Results: The cancer registry provided 10 female patients with Ann Arbor Stage II HL, aged 10-18 years at the time of treatment. Both mean and maximum breast dose were significantly less with BS-PT compared with 3D-CRT: 0.95 CGE vs. 4.70 Gy (p < 0.001) and 21.07 CGE vs. 23.11 Gy (p < 0.001), respectively. The volume of breast receiving 1.0 Gy/CGE and 5.0 Gy/CGE was also significantly less with BS-PT, 194 cm{sup 3} and 93 cm{sup 3}, respectively, compared with 790 cm{sup 3} and 360 cm{sup 3} with 3D-CRT (p = 0.009, 0.013). Conclusion: Breast-sparing proton therapy has the potential to reduce unnecessary breast dose in young girls with HL by as much as 80% relative to involved-field 3D-CRT.

  9. An evaluation of the TSE MR sequence for time efficient data acquisition in polymer gel dosimetry of applications involving high doses and steep dose gradients

    SciTech Connect (OSTI)

    Baras, P.; Seimenis, I.; Sandilos, P.; Vlahos, L.; Bieganski, T.; Georgiou, E.; Pantelis, E.; Papagiannis, P.; Sakelliou, L. [Philips Hellas Medical Systems, 44 Kifissias Ave., Maroussi 151 25, Athens (Greece); Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece) and Medical Physics Department, Hygeia Hospital, Kiffisias Avenue, 24 Erythrou Stavrou, Marousi, 151 23, Athens (Greece); Department of Radiology, Mother's Memorial Hospital, Rzgowska 281/289, 93-388, Lodz (Poland); Medical Physics Department, University of Athens, 75 Mikras Asias, 115 27 Athens (Greece); Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens (Greece)

    2005-11-15T23:59:59.000Z

    The use of magnetic resonance imaging as a readout method for polymer gel dosimetry commonly involves long imaging sessions, particularly when high spatial resolution is required in all three dimensions, for the investigation of dose distributions with steep dose gradients and stringent dose delivery specifications. In this work, a volume selective turbo spin echo (TSE) pulse sequence is compared to the established Carr-Purcell-Meiboom-Gill (CPMG) multiecho acquisition with regard to providing accurate dosimetric results in significantly reduced imaging times. Polyethylene glycol diacrylate based (PABIG) gels were irradiated and subsequently scanned to obtain R2 relaxation rate measurements, using a CPMG multiecho sequence and a dual echo TSE utilizing an acceleration (turbo) factor of 64. R2 values, plotted against corresponding Monte Carlo dose calculations, provided calibration data of PABIG gels dose response over a wide dose range. A linear R2 versus dose relationship was demonstrated for both sequences with TSE results presenting reduced dose sensitivity. Although TSE data were found to deviate from linearity at lower doses compared to CPMG data, a relatively wide dynamic dose range of response extending up to approximately 100 Gy was observed for both sequences. The TSE and CPMG sequences were evaluated with a brachytherapy irradiation using a high dose rate {sup 192}Ir source and a gamma knife stereotactic radiosurgery irradiation with a single 4 mm collimator helmet shot. Dosimetric results obtained with the TSE and CPMG are shown to compare equally well with the expected dose distributions for these irradiations. The 60-fold scan time reduction achieved with TSE implies that this sequence could prove to be a useful tool for the introduction of polymer gel dosimetry in clinical radiation therapy applications involving high doses and steep dose gradients.

  10. Landscaping encompasses all the features that add beauty and utility to your property beyond the walls of your home. Plants are one primary element of landscape design. Good design with plants involves an

    E-Print Network [OSTI]

    New Hampshire, University of

    the walls of your home. Plants are one primary element of landscape design. Good design with plants involves to be "usefully hardy" in your area. Though a plant may grow fairly well, if it is sufficiently injured by cold

  11. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

    SciTech Connect (OSTI)

    Hong, Wei, E-mail: hongwei@tijmu.edu.cn [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China) [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Li, Jinru; Wang, Bo [College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China)] [College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Chen, Linfeng [Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, 02115 MA (United States)] [Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, 02115 MA (United States); Niu, Wenyan; Yao, Zhi [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China)] [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); Baniahmad, Aria, E-mail: aban@mti.uni-jena.de [Institute for Human Genetics, Jena University Hospital, 07740 Jena (Germany)] [Institute for Human Genetics, Jena University Hospital, 07740 Jena (Germany)

    2011-12-02T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Corepressor Alien interacts with histone methyltransferase ESET in vivo. Black-Right-Pointing-Pointer Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TR{beta}1. Black-Right-Pointing-Pointer ESET-mediated H3K9 methylation is required for liganded TR{beta}1-repressed transcription. Black-Right-Pointing-Pointer ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by which Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TR{beta}1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TR{beta}1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TR{beta}1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TR{beta}1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.

  12. t(8; 14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region

    SciTech Connect (OSTI)

    Haluska, F.G.; Tsujimoto, Y.; Croce, C.M.

    1987-10-01T23:59:59.000Z

    Recent molecular analyses of Burkitt lymphomas carrying the t(8;14) chromosome translocation have indicated that a dichotomy exists regarding the molecular mechanisms by which the translocations occur. Most sporadic Burkitt tumors carry translocations that apparently arise due to mistakes in the immunoglobulin isotype-switching process. In contrast, there is evidence that the translocations of most endemic Burkitt lymphomas occur as a consequence of aberrant V-D-J recombination of variable, diversity, and joining gene segments, catalyzed by the recombinase enzymes. This phenomenon was first noted in follicular lymphomas and chronic lymphocytic leukemias of the B-cell lineage and has been described in T-cell malignancies as well. In each of these cases, analysis of the nucleotide sequence at chromosome breakpoints demonstrated the involvement of immunoglobulin heavy chain J/sub H/ or T-cell-receptor ..cap alpha..-chain J..cap alpha.. gene segments in the translocation. The authors now have cloned and sequenced both the 8q- and 14q+ translocation breakpoints deriving from the t(8;14) translocation of the endemic Burkitt lymphoma line Daudi. The data show that the translocation resulted from a reciprocal exchange between the D/sub H/ region on chromosome 14 and sequences far 5' of the MYC protooncogene on chromosome 8. Features of the nucleotide sequences surrounding the breakpoint further implicate the V-D-J joining machinery in the genesis of chromosome translocation in endemic Burkitt lymphomas and, more generally, in other lymphoid malignancies as well.

  13. The Fas-associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in TNF-induced activation of ERK

    SciTech Connect (OSTI)

    Lueschen, Silke [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Falk, Markus [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Scherer, Gudrun [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Ussat, Sandra [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Paulsen, Maren [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Adam-Klages, Sabine [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany)]. E-mail: sadam@email.uni-kiel.de

    2005-10-15T23:59:59.000Z

    The cytokine TNF activates multiple signaling pathways leading to cellular responses ranging from proliferation and survival to apoptosis. While most of these pathways have been elucidated in detail over the past few years, the molecular mechanism leading to the activation of the MAP kinases ERK remains ill defined and is controversially discussed. Therefore, we have analyzed TNF-induced ERK activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner. In addition, we provide evidence for the involvement of the signaling components Fas-associated death domain protein (FADD), caspase-8, and c-FLIP in the pathway activating ERK in response to TNF. This conclusion is based on the following observations: (I) Overexpression of FADD, caspase-8, or a c-FLIP protein containing the death effector domains only leads to enhanced and prolonged ERK activation after TNF treatment. (II) TNF-induced ERK activation is strongly diminished in the absence of FADD. Interestingly, the enzymatic function of caspase-8 is not required for TNF-induced ERK activation. Additional evidence suggests a role for this pathway in the proliferative response of murine fibroblasts to TNF.

  14. Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR{gamma} activation

    SciTech Connect (OSTI)

    Takahashi, Nobuyuki; Goto, Tsuyoshi; Taimatsu, Aki; Egawa, Kahori; Katoh, Sota; Kusudo, Tatsuya; Sakamoto, Tomoya; Ohyane, Chie; Lee, Joo-Young; Kim, Young-il; Uemura, Taku; Hirai, Shizuka [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan)] [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan); Kawada, Teruo, E-mail: fat@kais.kyoto-u.ac.jp [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan)] [Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011 (Japan)

    2009-12-25T23:59:59.000Z

    Insulin resistance is partly due to suppression of insulin-induced glucose uptake into adipocytes. The uptake is dependent on adipocyte differentiation, which is controlled at mRNA transcription level. The peroxisome proliferator-activated receptor (PPAR), a ligand-regulated nuclear receptor, is involved in the differentiation. Many food-derived compounds serve as ligands to activate or inactivate PPAR. In this study, we demonstrated that bixin and norbixin (annatto extracts) activate PPAR{gamma} by luciferase reporter assay using GAL4-PPAR chimera proteins. To examine the effects of bixin on adipocytes, 3T3-L1 adipocytes were treated with bixin or norbixin. The treatment induced mRNA expression of PPAR{gamma} target genes such as adipocyte-specific fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and adiponectin in differentiated 3T3-L1 adipocytes and enhanced insulin-dependent glucose uptake. The observations indicate that bixin acts as an agonist of PPAR{gamma} and enhances insulin sensitivity in 3T3-L1 adipocytes, suggesting that bixin is a valuable food-derived compound as a PPAR ligand to regulate lipid metabolism and to ameliorate metabolic syndrome.

  15. Nanowires, Capacitors, and Other Novel Outer-Surface Components Involved in Electron Transfer to Fe(III) Oxides in Geobacter Species

    SciTech Connect (OSTI)

    Lovley, Derek, R.

    2008-12-22T23:59:59.000Z

    The overall goal of this project was to better understand the mechanisms by which Geobacter species transfer electrons outside the cell onto Fe(III) oxides. The rationale for this study was that Geobacter species are often the predominant microorganisms involved in in situ uranium bioremediation and the growth and activity of the Geobacter species during bioremediation is primarily supported by electron transfer to Fe(III) oxides. These studies greatly expanded the understanding of electron transfer to Fe(III). Novel concepts developed included the potential role of microbial nanowires for long range electron transfer in Geobacter species and the importance of extracytoplasmic cytochromes functioning as capacitors to permit continued electron transfer during the hunt for Fe(III) oxide. Furthermore, these studies provided target sequences that were then used in other studies to tract the activity of Geobacter species in the subsurface through monitoring the abundance of gene transcripts of the target genes. A brief summary of the major accomplishments of the project is provided.

  16. Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2

    SciTech Connect (OSTI)

    Han Suxia; He Guangming; Wang Tao; Chen Lei; Ning Yunye; Luo Feng; An Jin; Yang Ting; Dong Jiajia; Liao Zenglin; Xu Dan [Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China); Wen Fuqiang, E-mail: wenfuqiang.scu@gmail.co [Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 (China)

    2010-05-15T23:59:59.000Z

    Chronic cigarette smoking induces pulmonary arterial hypertension (PAH) by largely unknown mechanisms. Renin-angiotensin system (RAS) is known to function in the development of PAH. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in regulating angiotensin-converting enzyme-2 (ACE2), a recently found regulator of RAS. To determine the effect of losartan on smoke-induced PAH and its possible mechanism, rats were daily exposed to cigarette smoke for 6 months in the absence and in the presence of losartan. Elevated right ventricular systolic pressure (RVSP), thickened wall of pulmonary arteries with apparent medial hypertrophy along with increased angiotensin II (Ang II) and decreased ACE2 levels were observed in smoke-exposed-only rats. Losartan administration ameliorated pulmonary vascular remodeling, inhibited the smoke-induced RVSP and Ang II elevation and partially reversed the ACE2 decrease in rat lungs. In cultured primary pulmonary artery smooth muscle cells (PASMCs) from 3- and 6-month smoke-exposed rats, ACE2 levels were significantly lower than in those from the control rats. Moreover, PASMCs from 6-month exposed rats proliferated more rapidly than those from 3-month exposed or control rats, and cells grew even more rapidly in the presence of DX600, an ACE2 inhibitor. Consistent with the in vivo study, in vitro losartan pretreatment also inhibited cigarette smoke extract (CSE)-induced cell proliferation and ACE2 reduction in rat PASMCs. The results suggest that losartan may be therapeutically useful in the chronic smoking-induced pulmonary vascular remodeling and PAH and ACE2 may be involved as part of its mechanism. Our study might provide insight into the development of new therapeutic interventions for PAH smokers.

  17. Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB{sub 1} receptors and apoptotic cell death

    SciTech Connect (OSTI)

    Tomiyama, Ken-ichi; Funada, Masahiko, E-mail: mfunada@ncnp.go.jp

    2014-01-01T23:59:59.000Z

    The abuse of herbal products containing synthetic cannabinoids has become an issue of public concern. The purpose of this paper was to evaluate the acute cytotoxicity of synthetic cannabinoids on mouse brain neuronal cells. Cytotoxicity induced by synthetic cannabinoid (CP-55,940, CP-47,497, CP-47,497-C8, HU-210, JWH-018, JWH-210, AM-2201, and MAM-2201) was examined using forebrain neuronal cultures. These synthetic cannabinoids induced cytotoxicity in the forebrain cultures in a concentration-dependent manner. The cytotoxicity was suppressed by preincubation with the selective CB{sub 1} receptor antagonist AM251, but not with the selective CB{sub 2} receptor antagonist AM630. Furthermore, annexin-V-positive cells were found among the treated forebrain cells. Synthetic cannabinoid treatment induced the activation of caspase-3, and preincubation with a caspase-3 inhibitor significantly suppressed the cytotoxicity. These synthetic cannabinoids induced apoptosis through a caspase-3-dependent mechanism in the forebrain cultures. Our results indicate that the cytotoxicity of synthetic cannabinoids towards primary neuronal cells is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and further suggest that caspase cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. In conclusion, excessive synthetic cannabinoid abuse may present a serious acute health concern due to neuronal damage or deficits in the brain. - Highlights: • Synthetic cannabinoids (classical cannabinoids, non-classical cannabinoids, and aminoalkylindole derivatives) induce cytotoxicity in mouse forebrain cultures. • Synthetic cannabinoid-induced cytotoxicity towards forebrain cultures is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and involves caspase-dependent apoptosis. • A high concentration of synthetic cannabinoids may be toxic to neuronal cells that express CB{sub 1} receptors.

  18. The accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Li, Yuan [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Li, Huiqiao [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China)] [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China); Pang, Ying; Zhao, Yue; Jiang, Rongrong; Shen, Lu [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Zhou, Jianwei; Wang, Xinru [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)] [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Liu, Qizhan, E-mail: drqzliu@hotmail.com [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)

    2013-01-15T23:59:59.000Z

    The biphasic effects of arsenite, in which low levels of arsenite induce cell proliferation and high levels of arsenite induce DNA damage and apoptosis, apparently contribute to arsenite-induced carcinogenesis. However, the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the effects of different levels of arsenite on cell proliferation, DNA damage and apoptosis as well as on signal transduction pathways in human bronchial epithelial (HBE) cells. Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2? (HIF-2?) in HBE cells. ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2?. In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1? degradation. Down-regulation of HIF-1? by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite. Thus, data in the present study suggest that the accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. -- Highlights: ? Biphasic effects induced by different concentrations of arsenite. ? Different regulation of ERK or JNK signal pathway by arsenite. ? Different regulation of HIF1? or HIF 2? by arsenite.

  19. MAPK/ERK and Wnt/{beta}-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells

    SciTech Connect (OSTI)

    Jin, Caixia [Department of Surgery, University of North Carolina at Chapel Hill (United States) [Department of Surgery, University of North Carolina at Chapel Hill (United States); Department of Medical Genetics and Cell Biology, Ningxia Medical University, Yinchuan 750004 (China); Samuelson, Lisa; Cui, Cai-Bin; Sun, Yangzhong [Department of Surgery, University of North Carolina at Chapel Hill (United States)] [Department of Surgery, University of North Carolina at Chapel Hill (United States); Gerber, David A., E-mail: david_gerber@med.unc.edu [Department of Surgery, University of North Carolina at Chapel Hill (United States); Lineberger Cancer Center, University of North Carolina at Chapel Hill (United States)

    2011-06-17T23:59:59.000Z

    Highlights: {yields} Activation of MAPK/ERK pathway with epidermal growth factor (EGF) significantly increased Sca-1{sup +} HPC proliferation and colony formation. {yields} Activation of either IL-6/STAT3 or Wnt/{beta}-Catenin pathway did not independently support cell proliferation and colony formation of HPCs. {yields} Wnt/{beta}-Catenin pathway can cooperate with EGF to significantly promote HPC colony formation and maintain long-term HPCs in vitro. -- Abstract: Hepatic progenitor cells (HPCs) persist in adulthood and have the potential to play a major role in regenerating diseased liver. However, the signaling pathways that both directly and indirectly regulate HPCs' self-renewal and differentiation remain elusive. Previously, we identified a bipotent, stem cell antigen-1 (Sca-1) positive HPC population from naive adult liver tissue. In the present study, we aimed to investigate the involvement of various signaling pathways in Sca-1{sup +} HPC proliferation. Epidermal growth factor (EGF) supplementation shows a significant increase in Sca-1{sup +} HPC proliferation and colony formation while stimulating phosphorylation of ERK1/2 and activating the induction of Cyclin D1. There were no demonstrable effects of EGF on Akt. The MEK inhibitor, PD0325901, inhibits proliferation and ERK1/2 phosphorylation while also suppressing the expression of Cyclin D1. In addition, activation of either IL-6/STAT3 or Wnt/{beta}-Catenin pathway did not independently support cell proliferation and colony formation of HPCs. The Wnt/{beta}-Catenin pathway can cooperate with EGF to significantly promote HPC colony formation ratio and maintain long-term HPC in vitro. The data indicates that the MAPK/ERK pathway is both essential and critical for HPC proliferation, and the Wnt signaling pathway is not sufficient, while it works synergistically with the MAPK/ERK signaling pathway to promote HPC proliferation.

  20. Twice-Weekly Hypofractionated Intensity-Modulated Radiotherapy for Localized Prostate Cancer With Low-Risk Nodal Involvement: Toxicity and Outcome From a Dose Escalation Pilot Study

    SciTech Connect (OSTI)

    Zilli, Thomas, E-mail: thomaszilli@inwind.it [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Jorcano, Sandra [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Rouzaud, Michel; Dipasquale, Giovanna; Nouet, Philippe [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Toscas, Jose Ignacio [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Casanova, Nathalie; Wang, Hui [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Escude, Lluis; Molla, Meritxell; Linero, Dolors [Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain); Weber, Damien C. [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Miralbell, Raymond [Service de Radio-oncologie, Hopitaux Universitaires de Geneve, Geneva (Switzerland); Servei de Radio-oncologia, Institut Oncologic Teknon, Barcelona (Spain)

    2011-10-01T23:59:59.000Z

    Purpose: To evaluate the toxicity and preliminary outcome of patients with localized prostate cancer treated with twice-weekly hypofractionated intensity-modulated radiotherapy (IMRT). Methods and Materials: Between 2003 and 2006, 82 prostate cancer patients with a nodal involvement risk {<=}20% (Roach index) have been treated to the prostate with or without seminal vesicles with 56 Gy (4 Gy/fraction twice weekly) and an overall treatment time of 6.5 weeks. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities were scored according to the Radiation Therapy Oncology Group (RTOG) grading system. Median follow-up was 48 months (range, 9-67 months). Results: All patients completed the treatment without interruptions. No patient presented with Grade {>=}3 acute GU or GI toxicity. Of the patients, 4% presented with Grade 2 GU or GI persistent acute toxicity 6 weeks after treatment completion. The estimated 4-year probability of Grade {>=}2 late GU and GI toxicity-free survival were 94.2% {+-} 2.9% and 96.1% {+-} 2.2%, respectively. One patient presented with Grade 3 GI and another patient with Grade 4 GU late toxicity, which were transitory in both cases. The 4-year actuarial biochemical relapse-free survival was 91.3% {+-} 5.9%, 76.4% {+-} 8.8%, and 77.5% {+-} 8.9% for low-, intermediate-, and high-risk groups, respectively. Conclusions: In patients with localized prostate cancer, acute and late toxicity were minimal after dose-escalation administering twice-weekly 4 Gy to a total dose of 56 Gy, with IMRT. Further prospective trials are warranted to further assess the best fractionation schemes for these patients.

  1. Water-soluble organometallic compounds. 3. Kinetic investigations of dissociative phosphine substitution processes involving water-soluble group 6 metal derivatives in miscible aqueous/organic media

    SciTech Connect (OSTI)

    Darensbourg, D.J.; Bischoff, C.J. (Texas A M Univ., College Station (United States))

    1993-01-06T23:59:59.000Z

    Mechanistic aspects of ligand substitution reactions of group 6 metal carbonyl derivatives containing the trisulfonated phosphine P(m-C[sub 6]H[sub 4]SO[sub 3]Na)[sub 3] (hereafter referred to as TPPTS) in pure water and water/THF media have been investigated by examination of the reactions of these derivatives with carbon monoxide as an incoming ligand. The reactions, which were carried out under 500 psi of CO in the temperature range 110-160[degrees]C, were monitored in situ by infrared spectroscopy employing a cylindrical internal reflectance reactor. Kinetic measurements show the reactions are first-order in metal complex concentration and independent of CO pressure at high CO pressures, and the rates are retarded by added TPPTS. The activation parameters for TPPTS dissociation from M(CO)[sub 5]TPPTS derivatives (M = Mo, W), e.g., in 1:1 THF/H[sub 2]O, [Delta]H[double dagger] = 28.8 [plus minus] 1.4 kcal/mol and [Delta]S[double dagger] = [minus]4.2 [plus minus] 3.5 eu and [Delta]H[double dagger] = 31.8 [plus minus] 1.5 kcal/mol and [Delta]S[double dagger] = [minus]0.73 [plus minus] 3.6 eu, respectively were shown to be quite similar to those determined for the analogous processes involving the nonsulfonated PPh[sub 3] ligand in the same solvent systems. In addition only small solvent effects were noted in going from aqueous to organic solvents for these dissociative processes. For the cis-Mo(CO)[sub 4][TPPTS][sub 2] derivative, in which the sodium ions are encapsulated by a cryptand, kryptofix-221, a steric acceleration of TPPTS dissociation is noted relative to its PPh[sub 3] analog. 27 refs., 5 figs., 6 tabs.

  2. Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells

    SciTech Connect (OSTI)

    Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

    2013-11-15T23:59:59.000Z

    We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: • ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. • ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. • ?{sup 9}-THC impaired elevation of intracellular Ca2+. • ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

  3. NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell

    SciTech Connect (OSTI)

    Wang, Yi, E-mail: wangyi2004a@126.com [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China); Wang, Xiang; Sun, Minghui; Zhang, Zhenyu; Cao, Heng; Chen, Xiaoqing [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)

    2011-08-05T23:59:59.000Z

    Highlights: {yields} Ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. {yields} Ox-LDL induced expression of P-selectin through degradation of IkBa and augment of NF-kB activity and protein level during macrophage-derived foam cell formation. {yields} P-selectin and NF-kB may be identified as pivotal regulators of ox-LDL-induced foam cell formation. {yields} Therapy based on the inhibition of P-selectin and NF-kB may complement conventional treatments to prevent atherosclerosis. -- Abstract: Oxidized low-density lipoprotein (ox-LDL) plays a critical role in regulation of atherosclerosis. However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis. In this study, we first investigated ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. Treatment of U937 cells with ox-LDL increased lipid accumulation as well as intracellular cholesterol content. Next, a comparative analysis of gene expression profiling using cDNA microarray and Real-time-PCR indicated that ox-LDL exposure induced, in three treated groups, an extremely marked increase in the mRNA level of P-selectin. Protein levels of P-selectin and its upstream regulators IkBa and NF-kB showed that NF-kB pathway is involved in the ox-LDL-induced foam cell formation. Finally, overexpression of NF-kB significantly accelerated, whereas, inhibition of NF-kB with siRNA remarkably attenuated ox-LDL-induced macrophage-derived foam cell formation. It was concluded that the activity of NF-kB is augmented during macrophage-derived foam cell formation. Activation of NF-kB increased, whereas, inhibition of NF-kB decreased ox-LDL-induced P-selectin expression and lipid accumulation in macrophages, suggesting ox-LDL induced expression of P-selectin through degradation of IkBa and activation of NF-kB in the regulation of foam cell formation.

  4. Involvement of 5f-orbitals in the bonding and reactivity of organoactinide compounds: thorium(IV) and uranium(IV) bis (hydrazonato) complexes

    SciTech Connect (OSTI)

    Cantat, Thibault [Los Alamos National Laboratory; Graves, Christopher R [Los Alamos National Laboratory; Morris, David E [Los Alamos National Laboratory; Kiplinger, Jaqueline L [Los Alamos National Laboratory

    2008-01-01T23:59:59.000Z

    Migratory insertion of diphenyldiazomethane into both metal-carbon bonds of the bis(alkyl) and bis(aryl) complexes (C5Me5)2AnR2 yields the first f-element bis(hydrazonato) complexes (C5Me5)2An[2-(N,N')-R-N-NCPh2]2 [An = Th, R = CH3 (18), PhCH2 (15), Ph (16); An = U, R = CH3 (17), PhCH2 (14)], which have been characterized by a combination of spectroscopy, electrochemistry, and X-ray crystallography. The two hydrazonato ligands adopt an 2-coordination mode leading to 20-electron (for Th) and 22-electron (for U) complexes that have no transition-metal analogues. In fact, reaction of (C5H5)2Zr(CH3)2 or (C5Me5)2Hf(CH3)2 with diphenyldiazomethane is limited to the formation of the corresponding mono(hydrazonato) complex (C5R5)2M[2-(N,N')-CH3-N-NCPh2](CH3) (M = Zr, R = H or M = Hf, R = CH3). The difference in the reactivities of the group 4 metal complexes and the actinides was used as a unique platform for investigating in depth the role of 5f orbitals on the reactivity and bonding in actinide organometallic complexes. The electronic structure of the (C5H5)2M[2-(N,N')-CH3-N-NCH2]2 (M = Zr, Th, U) model complexes was studied using density functional theory (DFT) calculations and compared to experimental structural, electrochemical, and spectroscopic results. Whereas transition-metal bis(cyclopentadienyl) complexes are known to stabilize three ligands in the metallocene girdle to form saturated (C5H5)2ML3 species, in a bis(hydrazonato) system, a fourth ligand is coordinated to the metal center to give (C5H5)2ML4. DFT calculations have shown that 5f orbitals in the actinide complexes play a crucial role in stabilizing this fourth ligand by stabilizing both the s and p electrons of the two 2-coordinated hydrazonato ligands. In contrast, the stabilization of the hydrazonato ligands was found to be significantly less effective for the putative bis(hydrazonato) zirconium(IV) complex, yielding a higher energy structure. However, the difference in the reactivities of the group 4 metal and actinide complexes does not arise on thermodynamic grounds but is primarily of kinetic origin. Unfavorable steric factors have been ruled out as the sole influence to explain these different behaviors, and electronic factors were shown to govern the reactivity. For the actinides, both the C5H5 and more realistic C5Me5 ligands have been taken into account in computing the energy surface. The reaction profile for the C5Me5 system differs from that with the C5H5 ligand by a uniform shift of 5 kcal/mol in the relative energies of the transition state and products. The insertion of a second diazoalkane molecule into the sole metal-carbon bond in the mono(hydrazonato) complexes involves a high energy barrier (20 kcal/mol) for the zirconium(IV) system, whereas the actinides can facilitate the approach of the diazoalkane by coordination (formation of an adduct) and its insertion into the An-C bond with a very low barrier on the potential energy surface.

  5. Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued David Reboutier, Marie-Brengre Troadec, Jean-Yves Cremet, Lucie Chauvin, Vincent Guen, Patrick Salaun, and Claude Prigent

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued endogenous Aurora A: the sequence 59-CCTGTCTTACTGT-39, between positions 729 and 741, was replaced with 59 signaling molecules participate in this regulation, and they include the Aurora A kinase. Some

  6. The selective and timely degradation of proteins in the cell is important for overall protein homeostasis as well as an integral part of many cellular processes. One of the major proteases involved in the

    E-Print Network [OSTI]

    Strynadka, Natalie

    Abstract The selective and timely degradation of proteins in the cell is important for overall involved in the degradation of these polypeptide chains is the proteasome. The proteasome is formed by 66 degradation by unfolding substrates and regulating entry into the CP. The formation of proteasomes is assisted

  7. Leadership Transitioning AdaptedfromBowlingGreenUniversity-OfficeofCampusInvolvement Your last year as an officer is coming to an end and new officers are being selected. How do

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    Leadership Transitioning AdaptedfromBowlingGreenUniversity-OfficeofCampusInvolvement Your last year organization with strong leadership? Questions? Visit the Student Activities Office (Union 320) or call 940.565.3807 THOUROUGH LEADERSHIP TRANISITION HAS SEVERAL BENFITS: 1. The most obvious is that it provides for a transfer

  8. Crime Alert -Theft of Electronic Devices & A Personal Safety Reminder To follow up on the UCPD personal safety update sent to the community on the trends involving the theft of

    E-Print Network [OSTI]

    Mills, Allen P.

    Crime Alert - Theft of Electronic Devices & A Personal Safety Reminder To follow up on the UCPD personal safety update sent to the community on the trends involving the theft of electronic devices device on personal electronic devices. In addition to the recovery of those items, officers assigned

  9. A study utilizing a reaction involving DFP (Diisopropyl Fluorophosphate) and hydroxylamine or 2 - PAM (2 - Formyl - 1 -Methylpyridinium Oxime) for application to field evaluations of airborne concentrations of Organophosphates

    E-Print Network [OSTI]

    Blatnick, Neil Stephen

    1979-01-01T23:59:59.000Z

    A STUDY UTILIZING A REACTION INVOLVING DFP (DIISOPROPYL FLUOROPHOSPHATE) AND HYDROXYLAMLZ QR 2 - PAM (2 - FOR4IYL - 1 - METHYLPYRIDINIUM OXIME) FQR APPLICATIQN TO FIELD EVALUATIONS OF AIRBORNE CONCENTRATIONS OF ORGANOPHOSPHATES A Thesis... (DIISOPROPYL FLUOROPHOSPHATE) AND HYDROXYLAMINE OR 2 - PAM (2 ? FQRMYL - I ? METHYLPRIDINIUM OXIME) FQR APPLICATION TO FIELD EVALUATIONS OF AIRBORNE CQNCENTRATIQNS OF ORGANOPHOSPHATES A Thesis by NEIL STEPHEN BLATNICK Approved as to style and content by...

  10. The role of the school social worker in family involvement as identified by family specialists and parents in selected title I schools in North East Independent School District in San Antonio, Texas

    E-Print Network [OSTI]

    Canada, Gloria Lou

    2008-10-10T23:59:59.000Z

    variables influence parental involvement as reported by parents and family specialists, who are participants of the Parent Academy at the selected Title I elementary schools in the North East ISD, in San Antonio, Texas?” The results of this study strongly... parents have on determining the classes set forth for the Parent Academy, as reported by the parents and family specialists who are partici- pants of the Parent Academy at the selected Title I elementary campuses in the North East ISD in San Antonio...

  11. A Reversible Structural Interconversion Involving [M(H2pdc)2(H2O)2] 2H2O (M Mn, Fe, Co, Ni, Zn, H3pdc 3,5-pyrazoledicarboxylic acid) and the Role

    E-Print Network [OSTI]

    Li, Jing

    A Reversible Structural Interconversion Involving [M(H2pdc)2(H2O)2] ´ 2H2O (M Mn, Fe, Co, Ni, Zn, H3pdc 3,5-pyrazoledicarboxylic acid) and the Role of A Reactive Intermediate [Co(H2pdc)2] Long Pan, Nancy Ching, Xiaoying Huang, and Jing Li*[a] Abstract: A new type of hydrogen bonded networks [M(H2pdc)2

  12. Relativistic kinematics for reactions involving massless particles

    E-Print Network [OSTI]

    D. N. Basu; Tapan Mukhopadhyay

    2007-12-07T23:59:59.000Z

    Some useful kinematical relations for the absorption of a photon by a nucleus and its recoil are derived for the relativistic incident energies. These expressions provided for the relativistic kinematics of photoabsorption reactions, though simple, will be immensely useful for experimentalists as well as theoreticians.

  13. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01T23:59:59.000Z

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  14. Involvement of peptides in nitrogen fixation

    E-Print Network [OSTI]

    Ahlgren, Joy Annette

    1983-01-01T23:59:59.000Z

    as increased C in both roots and stems and a concomitant decrease in C per 14 32 unit mass of nodule. Ryle et al. (33) examined both red and white clovers; similar concentrations of C appeared in the terminal meri- 14 stem. In plants fixing nitrogen...

  15. Coal water suspensions involving carbon black

    SciTech Connect (OSTI)

    Malone, D.P.; Thompson, D.G.

    1988-10-25T23:59:59.000Z

    This patent describes a composition comprising: about 65 to 80% by weight of coal particulates with a particle size distribution within 10% of the value calculated in accordance with a Funk distribution which assumes a maximum coal particle size of about 300 microns and minimum coal particle size of about 0.5 microns; about 0.2 to 2% by weight, as based upon the total weight of dry coal, of carbon black having a primary carbon particle size in the range of about 200 to about 900 Angstroms which primary carbon particles are simultaneously bound together to form primary reticulated chains having lengths in the range of about 500 to 30,000 Angstroms; a carrier liquid comprising 20 to 35 wt % water; and from 0.2 to 2.0 wt % of a dispersant selected from the group consisting of ammonium naphthalene sulfonic acid, hexadecyltrimethylammonium bromide, and ammonium lignosulfonate.

  16. UT gets involved at Oak Ridge

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to maintain the momentum built up winning World War II and to keep the scientific brain trust at the Clinton Laboratories built during that amazing world changing period...

  17. Faculty Involved with the Alternative Energy Minor

    E-Print Network [OSTI]

    occurring in the area of hydrogen fuel cells, biofuels, and solar cells. Such technologies have been suggested for transportation (motor vehicles) and stationary (heating and electricity) applications of courses, 6-8 credits): _____ CM3110 Transport/Unit Operations I (3) and CM3120 Transport/Unit Operations

  18. involvement Patients Participate! was a collaborative project

    E-Print Network [OSTI]

    Rzepa, Henry S.

    government. The British Library is the UK's national library. We provide access to the world's most UKOLN, based at the University of Bath, the British Library and the Association of Medical Research and the public in deciding what research to fund. This is what the charity Asthma UK says about the role of lay

  19. Legal Issues Involving Cash Forward Grain Contracts

    E-Print Network [OSTI]

    McEowen, Roger A.

    1999-06-23T23:59:59.000Z

    requirement unclear and may be illegal under Commodity Future Trading Commission (CFTC) regulations that ban trade options (an off-exchange deriva- tive) on agricultural commodities. This has been a major issue since 1996 and the run-up in grain prices... the HTA con- tract and requiring the farmer to deliver, and others determining the contracts to be illegal under the CFTC ban. In general, HTA contracts will be upheld as cash-forward contracts if a court or arbitrator can determine that the con- tracts...

  20. Fukushima Media Involvement: Lessons Learned and Challenges

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Koller, Greg L.; Johnson, Wayne L.

    2013-04-01T23:59:59.000Z

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the Department of Energy’s Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Within days, PNNL had set up a technical team in support of the U.S. government’s efforts to assist the devastated country. While a vast amount of information began to flow from Japan, the situation rapidly evolved challenging PNNL scientists and engineers, as well as news media and the general public to deal with a complex and often conflicting information stream. Over the course of about three weeks, PNNL’s News & Media Relations staff and its scientists and engineers responded to more than one hundred requests for information, and engaged in dozens of personal interviews with international, national, regional and local media. While many of the interviews and resulting stories were accurate and well done, to say that all communication went flawless would be far from the truth. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Even when communications guidelines are established and agreed-to ahead of time, and spokespeople promise to stay on message and within their areas of expertise, there is no guarantee the ball will not be dropped on occasion. Addressed here is “the rest of the story.”

  1. Department of Energy Idaho - Public Involvement Opportunity

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGas SeparationsRelevantDOEDelegations CurrentLaboratoryandPublic

  2. Community Involvement | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting theCommercialization and Innovation TheCommunications

  3. Public Involvement Plan | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR - TProcuring SolarNo. 195 - Oct. 7,Resumption of

  4. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducation Programs: CroSSlinks

  5. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducation Programs:

  6. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducation Programs:Education

  7. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducation

  8. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducationEducation Programs:

  9. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del Sol Home DistributionTransportation SafetyEnergyEducationEducation

  10. FOIASI - Special Inquiry Review of Allegations Involving

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers New Training on Energy Management Basics7-OPAMFax

  11. Sandia National Laboratories: About Sandia: Community Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear PressLaboratorySoftware100 Resilient Cities -

  12. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear PressLaboratorySoftware100 Resilient Cities -Contribution

  13. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear PressLaboratorySoftware100 Resilient Cities

  14. Sandia National Laboratories: Community Involvement: Volunteer Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear PressLaboratorySoftware100Life atCareers StudentsCommunity

  15. Community Involvement and Making a Difference

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration would like submit the followingth Lomonosov Conference,

  16. Strategic Public Involvement Products For Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our Instagram Secretary900Steep SlopeStochasticPlan FY14-FY18Strategic

  17. Strategic Public Involvement Â… Tool Time!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over Our Instagram Secretary900Steep SlopeStochasticPlan FY14-FY18StrategicLiz Mattson,

  18. Decontamination Dressdown at a Transportation Accident Involving

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T,Office of Policy, OAPMMilestone |Procurement of, 2011Department of

  19. Public Involvement Plan | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergy Small Team Oversight Activities - June 2012Notice |2002 |Public

  20. Mound Site Community Involvement Plan 2012

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City, Arizona, DisposalFourth Five-Year38Report3 Through

  1. RAPID/Get Involved | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I GeothermalPotentialBiopowerSolidGenerationMethodInformation Texas <Field <New Mexico

  2. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET

  3. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETING SUMMARY

  4. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETING SUMMARYJune 1,

  5. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETING SUMMARYJune

  6. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETING SUMMARYJune11,

  7. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETING

  8. Public Involvement and Communications Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70COMMUNITY AEROSOL INLET8, 2012 FINAL MEETINGFlipchart Notes

  9. Study on proliferative responses to host Ia antigens in allogeneic bone marrow chimera in mice: sequential analysis of the reactivity and characterization of the cells involved in the responses

    SciTech Connect (OSTI)

    Iwabuchi, K.; Ogasawara, K.; Ogasawara, M.; Yasumizu, R.; Noguchi, M.; Geng, L.; Fujita, M.; Good, R.A.; Onoe, K.

    1987-01-01T23:59:59.000Z

    Irradiation bone marrow chimeras were established by reconstitution of lethally irradiated AKR mice with C57BL/10 marrow cells to permit serial analysis of the developing reactivities of lymphocytes from such chimeras, (B10----AKR), against donor, host, or third party antigens. We found that substantial proliferative responses to Ia antigens of the recipient strain and also to third party antigens were generated by the thymocytes obtained from the irradiation chimeras at an early stage after bone marrow reconstitution. The majority of the responding thymocytes had surfaces lacking demonstrable peanut agglutinin receptors and were donor type Thy-1+, Ly-2-, and L3T4+ in both anti-recipient and anti-third party MLR. In anti-host responses, however, Ly-2+ thymocytes seemed to be at least partially involved. This capacity of thymus cells to mount a response to antigens of the recipient strain declined shortly thereafter, whereas the capacity to mount MLR against third party antigens persisted. The spleen cells of (B10----AKR) chimeras at the same time developed a more durable capability to exhibit anti-host reactivities and a permanent capability of reacting to third party allo-antigens. The stimulator antigens were Ia molecules on the stimulator cells in both anti-recipient and anti-third party MLR. The responding splenocytes were of donor origin and most of them had Thy-1+, Ly-1+2-, and L3T4+ phenotype.

  10. Test plan for composting studies involving weight and volume reduction of leaf and stalk biomass: DOE/OTD TTP{number_sign} SR17SS53 {ampersand} TTP{number_sign} SR18SS41

    SciTech Connect (OSTI)

    Wilde, E.W.; Kastner, J.; Murphy, C.; Santo Domingo, J.

    1997-05-28T23:59:59.000Z

    SRTC and a panel of experts from off-site previously determined that composting was the most attractive alternative for reducing the volume and weight of biomass that was slightly radioactive. The SRTC proposed scope of work for Subtask 2 of TTP{number_sign} SR17SS53 and TTP{number_sign} SR18SS41 involves bench scale studies to assess the rates and efficiencies of various composting schemes for volume and weight reduction of leaf and stalk biomass (SB). Ultimately, the data will be used to design a composting process for biomass proposed by MSE for phytoremediation studies at SRS. This could drastically reduce costs for transporting and disposing of contaminated biomass resulting from a future major phytoremediation effort for soil clean-up at the site. The composting studies at SRTC includes collaboration with personnel from the University of Georgia, who will conduct chemical analyses of the plant material after harvest, pre-treatment, and composting for specific time periods. Parameters to be measured will include: lignin, hemicellulose, cellulose, carbon and nitrogen. The overall objective of this project is to identify or develop: (1) an inexpensive source of inoculum (consisting of nutrients and/or microorganisms) capable of significantly enhancing biomass degradation, (2) an optimum range of operating parameters for the composting process, and (3) a process design for the solid state degradation of lignocellulosic biomass contaminated with radionuclides that is superior to existing alternatives for dealing with such waste.

  11. Assistant Director of Involvement Office for Student Leadership, Involvement & Community Engagement

    E-Print Network [OSTI]

    , website informational updates, Resource Room, Student Organizations Suite, etc. Provide advice and counsel University (ASCSU) administrative assistant, one Student Affairs in Higher Education graduate coordinator, and evaluate training, leadership, organizational, personal development, and diversity education programs

  12. TRANSPORT INVOLVING CONDUCTING FIBERS IN A NON-CONDUCTING MATRIX

    E-Print Network [OSTI]

    Walker, D. Greg

    to sev- eral applications including flexible thin-film transistors, PEM fuel cells, and direct energy, particularly Peltier devices, high electrical conductivity and low thermal conductivity are preferred

  13. anaerobic microorganisms involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    De Lillo,1 show that fluid acceleration reorients gyrotactic plankton, triggering small-scale clustering. We that fluid acceleration generates multifractal plankton clustering,...

  14. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01T23:59:59.000Z

    Adoption: The Case of Energy- Efficiency Audits. Resource695. Expert Group on Energy Efficiency. 2007. Realizing theDiscount Rates and Energy Efficiency. Contemporary Economic

  15. aggregates involves smad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of these quantum diffusion-limited aggregates vary between 1.43 and 2, depending on the size of the initial wave packet. David B. Johnson; Gonzalo Ordez 2011-11-02 96...

  16. TWO PROBLEMS INVOLVING THE NOTION OF PHASE TRANSITION

    E-Print Network [OSTI]

    Galvin, David

    Milas, David Radnell, Cliff Smyth and James and Yuka Taylor, for sharing their time and thoughts with me´os and Peter Winkler; and finally my parents, for their endless love and support. iv #12;Dedication To Nastia

  17. atom collisions involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reaction rate constants. The reaction products are identified by in-trap mass spectrometry, revealing the branching ratio between radiative and non-radiative charge exchange...

  18. artery disease involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    E. Lundquist; James P. Ward 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. aquaculture industries involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - TxSpace Summary: Utilizing waste heat from thermal electric or hydro-electric power stations offers substantial energy and cost savings to both the salmon aquaculture and...

  20. adipose tissue involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to -30C and held for 90 min, using a computer-controlled freeze... Davidenko, Natalia; Campbell, J. J.; Thian, E. S.; Watson, C. J,; Cameron, Ruth Elizabeth 2010-01-01 115...

  1. airway stenoses involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    equine respiratory diseases. RAO is an allergic asthma like disease of the middle-aged horses while the R. equi pneumonia affects only young foals. Respiratory... Kachroo,...

  2. Fission involves a new state of nuclear matter

    E-Print Network [OSTI]

    C. Ythier; S. Hachem; G. Mouze

    2011-01-10T23:59:59.000Z

    The rearrangement step of nuclear fission occurs within 0.17 yoctosecond, in a new state of nuclear matter characterized by the formation of closed shells of nucleons. The determination of its lifetime is now based on the prompt neutron emission law. The width of isotopic distributions measures the uncertainty in the neutron number of the fragments. Magic mass numbers, 82 and 126, play a major role in the mass distributions. Arguments are presented in favour of an all-neutron state. The boson field responsible for the new collective interaction has to be searched for.

  3. On "Sub-Threshold" Reactions Involving Nuclear Fission

    E-Print Network [OSTI]

    M. Goldhaber; R. Shrock

    2000-11-29T23:59:59.000Z

    We analyze reactions of several types that are naively below threshold but can proceed because of the release of binding energy from nuclear fission and occasionally the formation of Coulombic bound states. These reactions include (i) photofission with pion production and (ii) charged current neutrino-nucleus reactions that lead to fission and/or formation of a Coulomb bound state of a $\\mu^-$ with the nucleus of a fission fragment. We comment on the possible experimental observation of these reactions.

  4. Multiscale treatment of mechanical contact problems involving thin polymeric layers

    E-Print Network [OSTI]

    of energy wasted because of friction, which occurs in particular between mechanical components such as gears, such as providing protective or fouling-resistant coatings for manufacturing [5, 7, 8]. Of special interest

  5. FOIASI - Special Inquiry Review of Allegations InvolvingPotentialMisc...

    Energy Savers [EERE]

    Federal and contractor officials to access subcontractor personnel files for data mining of demographic information in violation of the procedures for protecting persondly...

  6. An external dose reconstruction involving a radiological dispersal device

    E-Print Network [OSTI]

    Hearnsberger, David Wayne

    2007-04-25T23:59:59.000Z

    phantom compared favorably to the derived organ absorbed doses measured by the Panasonic thermoluminescence dosimeters and with Monte Carlo �N� Particle modeled results. Additionally, a Victoreen 450P pressurized ion chamber measured...

  7. A time-stepping scheme involving constant coefficient matrices for ...

    E-Print Network [OSTI]

    S. Dong

    2012-06-21T23:59:59.000Z

    May 18, 2012 ... [15] G.E. Karniadakis, S.J. Sherwin, Spectral/hp Element Methods for Computational Fluid Dynamics, 2., Oxford University Press, 2005.

  8. Tax decisions involving the cost method of inventory valuation

    E-Print Network [OSTI]

    McMenamy, Bobby Benton

    1950-01-01T23:59:59.000Z

    )) CV'"AGLGCGL). Q~i~A ):46 $8)186 XA. L)QGSG), G)l 68))6 Z. MAX'GCG 6) 'i)6)')SGS 91)CQGGB4 GO G&5'. DGCGGGQ~ GGX' 6 LLG L') GL)i))C))). OQ Cf ))66 L)X'GLi . ' "LG CQLP~i )'GM. "K~G'~' 6)16 67'L)O L)1 ) 5L'LJPOC i) 6 'ii)'-'Qgr ' CG L)8'AGXGL64 0 i... ZDV8. 'AQl J 218 f. . ;GO&, '. l q'~llQll 'P6. 8 lgOvv, 'lg'1vO'~~";888 ', 8"v 88$, " OQl"~888 ~ v81 &vll8 88118~ 'Ail8 88+v1853. 8 DXQlvi vO81@~lI V4 GWI. "~4. 88k&%8"'p 2 2v ' viO ~ w3 gal% 14~8'vv&81181 48lvCI1 4Q"TOGS+ Vw CO'4!'8 882. o 18Pg Lf...

  9. Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

    E-Print Network [OSTI]

    Ding, Hui; Yan, Cai-Zhen; Shi, Honglian; Zhao, Ya-Shuo; Chang, Shi-Yang; Yu, Peng; Wu, Wen_Shuang; Zhao, Chen-Yang; Chang, Yan-Zhong; Duan, Xiang-Lin

    2011-09-21T23:59:59.000Z

    : #2; 2011 Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source... an important role in the management of iron metabolism. Accumulated evidence suggests that the transferrin– transferrin receptor (Tf–TfR) pathway might be the major route of iron transport across the luminal membrane of the capillary endothelium and iron uptake...

  10. activity involves sequential: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences Websites Summary: Sequential Consistency for Heterogeneous-Race-Free DEREK R. HOWER, BRADFORD M. BECKMANN, BENEDICT R: Sequential Consistency for Data-Race-Free (SC for...

  11. arms race involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences Websites Summary: Sequential Consistency for Heterogeneous-Race-Free DEREK R. HOWER, BRADFORD M. BECKMANN, BENEDICT R: Sequential Consistency for Data-Race-Free (SC for...

  12. Expanding public involvement in the restoration of federal facilities

    SciTech Connect (OSTI)

    Johnson, A.W.; Rouse, N.V. [ABB Environmental Services, Inc., Arlington, VA (United States); Lawley, S.B. [SOUTHNA VFACENGCOM, North Charleston, SC (United States)

    1994-12-31T23:59:59.000Z

    In February of 1994, the Navy released a guidance document entitled Establishment of Restoration Advisory Boards. This guidance recommends that all Navy facilities with practicing Technical Review Committees (TRCs) transition these committees into Restoration Advisory Boards, or RABS. Subsequently, the US Environmental Protection Agency (EPA), in concert with the Department of Defense (DOD), issued similar draft guidance that also strongly recommends this transition to RABs be accomplished. The intent of creating RABs is to increase community participation in the federal facility environmental restoration process. The RAB`s mission is to provide an avenue for early, two-way communication between the affected community and the environmental decision makers. The Navy strongly believes that implementing RABs will accelerate cleanups by ensuring that the affected communities have a voice early in the restoration process. The Navy is implementing this guidance at a number of Navy facilities, including bases that have been targeted for closure. This paper discusses DOD and Navy policy and joint EPA and DOD guidelines for implementing RABs, techniques to recruit additional community members, the process for selecting RAB members, orientation of RAB members, and RAB operational considerations. It also provides insight into what the Navy has learned by establishing RABs.

  13. active student involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is a COMPETITION for activities that promote professional development and learning among engineering students. 12;How much can-time students of SSE Value-added activities...

  14. accidents involving fuel: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ray upon decay. We find that pressurized light-water-reactors fueled with LEU-thorium fuel at high burnup (70 MWdkg) produce U-233 with U-232 contamination levels of about 0.4...

  15. Regulation and function of genes involved in drosophila ciliogenesis 

    E-Print Network [OSTI]

    Ma, Lina

    2011-06-27T23:59:59.000Z

    Proneural proteins are transcription factors of the bHLH family and have a conserved role in directing neurogenesis from invertebrate to mammals. In Drosophila, proneural proteins are required for early developmental ...

  16. Close encounters involving free-floating planets in star clusters

    E-Print Network [OSTI]

    Wang, Long; Zheng, Xiaochen; Church, Ross P; Davies, Melvyn B

    2015-01-01T23:59:59.000Z

    Instabilities in planetary systems can result in the ejection of planets from their host system, resulting in free-floating planets (FFPs). If this occurs in a star cluster, the FFP may remain bound to the star cluster for some time and interact with the other cluster members until it is ejected. Here, we use $N$-body simulations to characterise close star-planet and planet-planet encounters and the dynamical fate of the FFP population in star clusters containing $500-2000$ single or binary star members. We find that FFPs ejected from their planetary system at low velocities typically leave the star cluster 40% earlier than their host stars, and experience tens of close ($planets before they escape. The fraction of FFPs that experiences a close encounter depends on both the stellar density and the initial velocity distribution of the FFPs. Approximately half of the close encounters occur within the first 30 Myr, and only 10% occur after 100 Myr. The periastron vel...

  17. akt signaling involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Toll-like receptor signalling. Toll. Complex formation is a transient event in the process of signal transduction. Btk and the adaptive immune University of Ulm, Department...

  18. autocrine mechanism involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    buoyancy Effective designs for buoyant objects How to use; Swimming pool Lesson Description Students are introduced to principles of buoyancy. Students...

  19. Mechanism involved in enhancement of osteoblast differentiation by hyaluronic acid

    SciTech Connect (OSTI)

    Kawano, Michinao [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Ariyoshi, Wataru [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Iwanaga, Kenjiro [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Okinaga, Toshinori [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Habu, Manabu [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Yoshioka, Izumi [Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, University of Miyazaki, Kiyotake, Miyazaki 889-1692 (Japan)] [Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, University of Miyazaki, Kiyotake, Miyazaki 889-1692 (Japan); Tominaga, Kazuhiro [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Oral Bioresearch Center, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Nishihara, Tatsuji, E-mail: tatsujin@kyu-dent.ac.jp [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Oral Bioresearch Center, Kyushu Dental College, Kitakyushu 803-8580 (Japan)

    2011-02-25T23:59:59.000Z

    Research highlights: {yields} In this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. {yields} MG63 cells were incubated with BMP-2 and HA for various time periods. {yields} Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. {yields} HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation. -- Abstract: Objectives: Bone morphogenetic protein-2 (BMP-2) is expected to be utilized to fill bone defects and promote healing of fractures. However, it is unable to generate an adequate clinical response for use in bone regeneration. Recently, it was reported that glycosaminoglycans, including heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin-4-sulfate, chondroitin-6-sulfate, and hyaluronic acid (HA), regulate BMP-2 activity, though the mechanism by which HA regulates osteogenic activities has not been fully elucidated. The aim of this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. Materials and methods: Monolayer cultures of osteoblastic lineage MG63 cells were incubated with BMP-2 and HA for various time periods. To determine osteoblastic differentiation, alkaline phosphatase (ALP) activity in the cell lysates was quantified. Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by Western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. To further elucidate the role of HA in enhancement of BMP-2-induced Smad signaling, mRNA expressions of the BMP-2 receptor antagonists noggin and follistatin were detected using real-time RT-PCR. Results: BMP-2-induced ALP activation, Smad 1/5/8 phosphorylation, and nuclear translocation were up-regulated when MG63 cells were cultured with both BMP-2 and HA. Western blot analysis revealed that phosphorylation of ERK protein was diminished by HA. Furthermore, the mRNA expressions of noggin and follistatin induced by BMP-2 were preferentially blocked by HA. Conclusions: These results indicate that HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation.

  20. Quantization of gauge fields in gauges involving extra ghosts

    SciTech Connect (OSTI)

    Henneaux, M.

    1983-06-15T23:59:59.000Z

    Nielsen's recently proposed quantization rules, with gauge-fixing terms of the form F/sub a/..gamma../sup ab/F/sub b//2..cap alpha.., where ..gamma../sup a/b is field dependent, are shown to lead to an S matrix which is both unitary and gauge independent. The demonstration relies on the canonical form of the path integral.

  1. aba signaling involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    observed at the diploid genome level were not necessarily reflected in synthetic wheats. However, synthetic wheats derived from the parental Ae. tauschii accessions with...

  2. Host cell factors involved in retrovirus replication and disease pathogenesis

    E-Print Network [OSTI]

    Seidel, Shannon Beth

    2012-01-01T23:59:59.000Z

    suspension through a 70uM cell strainer and incubated in ACKa 70uM nylon mesh cell strainer and washed through usingrun through a 70uM cell strainer into cell culture media (

  3. Measurement of tau-decays involving eta-mesons

    E-Print Network [OSTI]

    Ammar, Raymond G.; Ball, S.; Baringer, Philip S.; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kelly, M.; Kwak, Nowhan; Lam, H.

    1992-12-01T23:59:59.000Z

    The decay tau- --> nu(tau)pi-pi0eta has been observed for the first time using the CLEO-II detector at the Cornell Electron Storage Ring. The measured branching ratio (0.17 +/- 0.02 +/- 0.02)%, agrees with the CVC (conserved ...

  4. analytical system involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Analytics. Desired: Successful completion of graduate courses in general linear models or statistical quality control Shepp, Larry 3 Analytic reconstruction of some...

  5. Farmer involvement in a reforestation research project in Costa Rica

    E-Print Network [OSTI]

    Toness, Anna Sutherland

    1993-01-01T23:59:59.000Z

    Research Project In Costa Rica Anna Sutherland Toness INTRODVCTION Widespread concern has risen in recent years over the increasing amount of deforestation in the tropics (Armis, 1992; Southgate et al. , 1991; Myers, 1991; Clay, 1988). Deforestation.... Citations follow the style of International Forestry Deforestation in tropical areas is also potentially more dangerous than in temperate forests. Tropical soils being much older and more highly weathered than temperate soils, no longer have the nutrient...

  6. Physical Models of Noncovalent Interactions Involving Aromatic Rings

    E-Print Network [OSTI]

    Bloom, Jacob Walter Goldstein

    2014-04-17T23:59:59.000Z

    of the interaction energies for sandwich dimers of Bz-X…Tz(N) versus Bz-X…Tz(C), at R = 4.0 Å. ............................................................................................................. 63 Figure 4.8: Electrostatic potential (solid colors, kcal...) for sandwich dimers of (a) Bz-X…Tz(C) versus Bz-X…Tz(N) and (b) Bz-X…Bz versus Bn(N)-X…Bz. ................................................................................................ 58 Figure 4.6: (a) Relative SAPT0 interaction energies (R = Re) and (b...

  7. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01T23:59:59.000Z

    S. J. 1993. Selling Issues to Top Management. Academy ofD. 1992. Diversification Posture and Top Management Teamas A Reflection of Its Top Managers. Academy of Management

  8. Processing and analysis techniques involving in-vessel material generation

    DOE Patents [OSTI]

    Schabron, John F. (Laramie, WY); Rovani, Jr., Joseph F. (Laramie, WY)

    2011-01-25T23:59:59.000Z

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  9. Communication methods, systems, apparatus, and devices involving RF tag registration

    DOE Patents [OSTI]

    Burghard, Brion J. (W. Richland, WA); Skorpik, James R. (Kennewick, WA)

    2008-04-22T23:59:59.000Z

    One technique of the present invention includes a number of Radio Frequency (RF) tags that each have a different identifier. Information is broadcast to the tags from an RF tag interrogator. This information corresponds to a maximum quantity of tag response time slots that are available. This maximum quantity may be less than the total number of tags. The tags each select one of the time slots as a function of the information and a random number provided by each respective tag. The different identifiers are transmitted to the interrogator from at least a subset of the RF tags.

  10. arterial feeders involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Graduate School has partnered with the Gradu- ate Feeders Scholars program at Florida A&M University to provide under Guidelines: Students applying for funding from Florida State...

  11. Host factors involved in viral movement through plants

    E-Print Network [OSTI]

    Seaberg, Bonnie Lee

    2009-05-15T23:59:59.000Z

    and total lesion count for spinach???????????? IV-3 GFP foci and total lesion count for cowpea???????????? Page 19 43 60 61 64 1 CHAPTER I INTRODUCTION Tomato bushy...) and solid tissue was strained out through a thin layer of cheesecloth. Subsequently, 5x cracking buffer was added in a 1:1 ratio and the mix was boiled for 5 minutes in a water bath. For phosphorylation assays, prior to adding the cracking buffer...

  12. acquired channelopathy involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems. We bel... Reiter, E; Sripada, S G; 10.1613jair.1176 2011-01-01 15 Acquired Dyslexia in Japanese: Implications for Reading Theory . Open Access Theses and Dissertations...

  13. An analysis of factors contributing to train-involved crashes

    E-Print Network [OSTI]

    Cooner, Scott Allen

    1995-01-01T23:59:59.000Z

    analyzed for the contributing factors. The contributing factors were classified into four categories: railroad factors, environmental factors, roadway factors, and driver/passenger factors. The accident data was analyzed using one and two-way classification...

  14. Worker Involvement Improves Safety at Hanford Site's Plutonium Finishing Plant

    Broader source: Energy.gov [DOE]

    Employees at the Hanford site are working together to find new and innovative ways to stay safe at the Plutonium Finishing Plant, one of the site’s most complex decommissioning projects.

  15. Identification and Localization of the CupB Protein Involved...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    fraction containing two protein complexes of about 450 and 550 kDa, obtained after nickel column and gel filtration chromatography of the membranes solubilized with...

  16. CHL1 is involved in human breast tumorigenesis and progression

    SciTech Connect (OSTI)

    He, Li-Hong [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Ma, Qin [Department of Oncology, The General Hospital of Tianjin Medical University, Tianjin (China)] [Department of Oncology, The General Hospital of Tianjin Medical University, Tianjin (China); Shi, Ye-Hui [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Ge, Jie; Zhao, Hong-Meng [Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Li, Shu-Fen [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Tong, Zhong-Sheng, E-mail: 83352162@qq.com [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

    2013-08-23T23:59:59.000Z

    Highlights: •CHL1 is down-regulation in breast cancer tissues. •Down-regulation of CHL1 is related to high grade. •Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. •CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression.

  17. aerogels involving carbon: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    carbon fiberscarbon aerogels composites by gelation and supercritical drying Materials Science Websites Summary: Fabrication of activated carbon fiberscarbon aerogels...

  18. RIS-M-2240 CLASSIFICATION SYSTEM FOR REPORTING EVENTS INVOLVING

    E-Print Network [OSTI]

    Risø National Laboratory, DK 4000 Roskilde, Denmark. #12;INIS-descriptors. BEHAVIOUR; DATA ACQUISITION

  19. A Time-Stepping Scheme Involving Constant Coefficient Matrices for ...

    E-Print Network [OSTI]

    flow domain, which includes phase field-dependent density/viscosity and a phase field-dependent force term. *Author of ..... k=0 ?k?n?k (J controls the order.

  20. Civic Engagement is active involvement in the discourse

    E-Print Network [OSTI]

    Bertini, Robert L.

    in Community-based Research Erna Gelles, Institute for Nonprofit Management/ Public Administration Warren

  1. assays involving extraction: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    400 plants to test their anti-obesity activity using porcine pancreatic lipase assay (PPL; triacylglycerol lipase, EC 3.1.1.3) in vitro activity. Among the 400 plants species...

  2. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01T23:59:59.000Z

    of Recommendations Top Management * Energy Costs/Sales TopTop Management Top Management * Energy Costs/Sales TopTop Management Top Management * Energy Costs/Sales Top

  3. DIVERGENT VIEWS The case against the involvement of the NMD

    E-Print Network [OSTI]

    Stahl, Guillaume

    on the proposed existence of a ribosome-bound complex of Upf proteins+ Such a complex remains hy- pothetical+ The only evidence for it is that Upf2p inter- acts with both Upf1p and Upf3p (He et al+, 1997) and that all+ (2000) showed that the Upf proteins are present at far below stoichio- metric with ribosomes

  4. aquaporin isoforms involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LdAQP2870 have the canonical NPA-NPA motifs, whereas LdAQP putative has a non-canonical NPM-NPA motif. In the carboxyl terminal to the second NPA box of all AQPs except AQP1, a...

  5. Security officer tactical training issues involving ESS equipment

    SciTech Connect (OSTI)

    Rountree, S.L.K.

    1984-01-01T23:59:59.000Z

    Security officer tactical training issues are discussed in relation to the possible implementation of the Tactical Improvement Package (TIP), utilizing the Engagement Simulation System (ESS) equipment, by nuclear power plant licensees for security officer tactical training. The ESS equipment provides the capability to simulate engagement conditions between adversaries armed with weapons which have harmless laser transmitters. A brief discussion of the TIP is presented, along with some concerns and considerations in the use of the TIP.

  6. Discovery of ubiquitin ligases involved in cytoplasmic quality control

    E-Print Network [OSTI]

    Heck, Jarrod Wesley

    2010-01-01T23:59:59.000Z

    Converging concepts of protein folding in vitro and in vivo.chaperones in cellular protein folding. Current Opinion inof endoplasmic reticulum protein folding. J Cell Biol, 2001.

  7. Metal catalyzed copolymerization processes involving carbon oxides as substrates

    E-Print Network [OSTI]

    Phelps, Andrea Lee

    2005-11-01T23:59:59.000Z

    to be selective for comonomer-alternating enchainment in the presence of PhCH2C(O)Co(CO)4 to afford poly-??-peptoids. The mechanistic aspects of the reaction of CO and Nbutylaziridine by means of in situ infrared spectroscopy employing CH3C(O)Co(CO)3L (L = PPh3...

  8. REGULAR ARTICLE Differential display of proteins involved in the neural

    E-Print Network [OSTI]

    Tian, Weidong

    significantly differential expression patterns in both quantity and quality. With mass spectrometry analysis actin, gamma-actin, actin-related protein 1, tropomyosin 1, and cofilin 1 are related to cell migration: July 28, 2004 Accepted: September 29, 2004 Keywords: Comparative proteomics / Mass spectrometry

  9. A primal-dual splitting method for convex optimization involving ...

    E-Print Network [OSTI]

    2011-12-16T23:59:59.000Z

    Dec 16, 2011 ... We propose a new first-order splitting algorithm for solving jointly the pri- ... volving the sum of a smooth function with Lipschitzian gradient, a ...

  10. CURRICULUM HIGHLIGHTS Fellows are actively involved in the

    E-Print Network [OSTI]

    Goldman, Steven A.

    experiences are teaching oriented and planned to enhance the fellows' academic careers. Peter G. Szilagyi, M:(585) 2755798 Fax:(585) 2762595 Peter_Szilagyi@urmc.rochester.edu Now accepting applications for 2014

  11. adolescent alcohol involvement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    law for which a minor may seek medical care for the prevention, diagnosis or treatment of the medical condition 296 Adolescent Impulsivity: A Mediator between Parental...

  12. Patterns of Arm Muscle Activation Involved in Octopus Reaching Movements

    E-Print Network [OSTI]

    Hochner, Binyamin

    (EMG)] was measured together with the kinematics of reaching movements. The traveling bend is associated with a propagat- ing wave of muscle activation, with maximal muscle activation slightly preceding with the kinematic variables (velocities and accelerations) re- veals that a significant part of the kinematic

  13. Involvement of TGF-beta in skin photoaging

    E-Print Network [OSTI]

    Choi, Won Seon, 1975-

    2005-01-01T23:59:59.000Z

    The goal of this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major ...

  14. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, C.L.; Thilly, W.G.

    1999-08-10T23:59:59.000Z

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.

  15. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Downers Grove, IL); Thilly, William G. (Winchester, MA)

    1985-01-01T23:59:59.000Z

    A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

  16. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Marblehead, MA); Thilly, William G. (Winchester, MA)

    1999-01-01T23:59:59.000Z

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

  17. Kinetics and mechanisms of reactions involving small aromatic reactive intermediates

    SciTech Connect (OSTI)

    Lin, M.C. [Emory Univ., Atlanta, GA (United States)

    1993-12-01T23:59:59.000Z

    Small aromatic radicals such as C{sub 6}H{sub 5}, C{sub 6}H{sub 5}O and C{sub 6}H{sub 4} are key prototype species of their homologs. C{sub 6}H{sub 5} and its oxidation product, C{sub 6}H{sub 5}O are believed to be important intermediates which play a pivotal role in hydrocarbon combustion, particularly with regard to soot formation. Despite their fundamental importance, experimental data on the reaction mechanisms and reactivities of these species are very limited. For C{sub 6}H{sub 5}, most kinetic data except its reactions with NO and NO{sub 2}, were obtained by relative rate measurements. For C{sub 6}H{sub 5}O, the authors have earlier measured its fragmentation reaction producing C{sub 5}H{sub 5} + CO in shock waves. For C{sub 6}H{sub 4}, the only rate constant measured in the gas phase is its recombination rate at room temperature. The authors have proposed to investigate systematically the kinetics and mechanisms of this important class of molecules using two parallel laser diagnostic techniques--laser resonance absorption (LRA) and resonance enhanced multiphoton ionization mass spectrometry (REMPI/MS). In the past two years, study has been focused on the development of a new multipass adsorption technique--the {open_quotes}cavity-ring-down{close_quotes} technique for kinetic applications. The preliminary results of this study appear to be quite good and the sensitivity of the technique is at least comparable to that of the laser-induced fluorescence method.

  18. Weak interaction processes in nuclei involving neutrinos and CDM candidates

    SciTech Connect (OSTI)

    Kosmas, T. S.; Tsakstara, V. [Theoretical Physics Section, University of Ioannina, GR 45110 Ioannina (Greece); Divari, P. C. [Department of Physical Sciences, Hellenic Army Academy, Vari 16673, Attica (Greece); Sinatkas, J. [Department of Informatics and Computer Technology, TEI of Western Macedonia, GR-52100 Kastoria (Greece)

    2009-11-09T23:59:59.000Z

    In this work, we concentrate on the nuclear physics aspects of low-energy neutrinos and in particular on problems related to neutrino detection by terrestrial experiments, neutrino astrophysics and neutrino-nucleus interactions. The detection of low-flux neutrinos, feasible by measuring the energy recoil of the recoiling nucleus with gaseous-detectors having very-low threshold-energy, is carried out in conjunction with direct-detection of cold dark matter events and nonstandard physics searches like the neutrinoless double beta decay.

  19. Projecting Fatalities in Crashes Involving Older Drivers, 20002025

    E-Print Network [OSTI]

    of Transportation under CRADA No. ORNL98-0500 Prepared by the OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee

  20. arabidopsis thaliana involved: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    occurring variation is an important alternative resource for functional genetics and genomics research.; In a well-characterized collection of Arabidopsis thaliana accessions, we...

  1. REPRODUCTIONRESEARCH Signal transduction mechanisms involved in in vitro ram sperm

    E-Print Network [OSTI]

    Zaragoza, Universidad de

    de Bioqui´mica y Biologi´a Molecular y Celular, Facultad de Veterinaria, C/Miguel Servet, 177, 50013

  2. Minors on Campus and/or Events Involving Minors

    E-Print Network [OSTI]

    Oklahoma, University of

    facilities, food preparation areas, high security areas; · Any areas, indoors or out, containing power tools-risk areas such as: · Laboratories, shops, studios, mechanical rooms, power plants, garages, animal is attending class or conducting any other business or social function on campus; · Line of sight supervision

  3. 1 INTRODUCTION The use of geosynthetics in modern landfills involves

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    and hydraulic properties. Geosynthetics also can offer technical advantages in relation to traditional liner at the Contrada Sabetta Dam, Italy (Cazzuffi 1987) and to keep an upstream clay seepage control liner from.g. compacted clays for liners, granular media for drainage layers, and various soils for protective

  4. Processing and analysis techniques involving in-vessel material generation

    DOE Patents [OSTI]

    Schabron, John F. (Laramie, WY); Rovani, Jr., Joseph F. (Laramie, WY)

    2012-09-25T23:59:59.000Z

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  5. Direct Involvement of Type II Secretion System in Extracellular...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    resulted in slightly yellowish supernatants, different from the pink supernatant of wild type (wt). Comparative proteomic analyses revealed that, although MtrC, OmcA and NrfA,...

  6. Parental involvement in mental health services for diverse youth

    E-Print Network [OSTI]

    Liang, June

    2010-01-01T23:59:59.000Z

    M. (2002). Mental health services for Latino adolescentsfamilies to mental health services: The role of the familyoutpatient mental health services. New York: Human Sciences

  7. Opportunities for utility involvement with solar domestic hot water

    SciTech Connect (OSTI)

    Carlisle, N.; Christensen, C. (National Renewable Energy Lab., Golden, CO (United States)); Barrett, L. (Barrett Consulting Associates, Inc., Colorado Springs, CO (United States))

    1992-05-01T23:59:59.000Z

    Solar water heating is one of a number of options that can be considered under utility demand-side management (DSM) programs. Utilities perceive a range of potential benefits for solar water heating in terms of customer service, energy conservation, load management, environmental enhancement, and public relations. The solar industry may benefit from utility marketing efforts, economies of scale, added credibility, financing options, and long-term maintenance arrangements. This paper covers three topics: (1) the energy and demand impacts of solar water heating on utility load profiles based on the results of four studies in the literature, (2) the results of workshops sponsored by the National Renewable Energy Laboratory (NREL) to identify key issues faced by utilities in considering residential solar water heating as a DSM option, (3) several current or planned utility programs to promote solar water heating. 7 refs.

  8. Fukushima Media Involvement: Lessons Learned and Challenges - 13261

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Johnson, Wayne L.; Koller, Greg L. [Department of Energy Pacific Northwest National Laboratory (United States)] [Department of Energy Pacific Northwest National Laboratory (United States)

    2013-07-01T23:59:59.000Z

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the DOE's Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following its announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Because PNNL develops state-of-the-art ultra-sensitive radionuclide detection and monitoring systems for national security applications, and has some of the equipment operating on its Richland campus, there was little surprise when one of these sophisticated systems led PNNL to be the first to detect measurable radionuclides in the United States. On Wednesday, March 16, 2011, that system detected minuscule levels of short-lived radioactive xenon, a telltale element derived from either weapons testing or a major reactor disruption. Immediately after the detection was announced, a flurry of inquiries nearly overwhelmed staff as governments, scientific organizations, the general public, and reporters struggled to understand and estimate what impacts this disaster might have on health and environment. Over the course of about three weeks, PNNL's News and Media Relations staff and its scientists and engineers responded to more than 100 requests for information, and engaged in dozens of personal interviews with international, national, regional, and local media. While many of the interviews and resulting stories were accurate and well done, not all communication went flawlessly. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Addressed here is 'the rest of the story'. (authors)

  9. Paducah WDA CERCLA Process & Public Involvement | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagementOPAM5 Accretion-of-DutiesPROPERTY3-0127Paducah Site PaducahCERCLA

  10. Tri-Party Agreement Agencies Annual Hanford Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2,EHSS A-Z Site MapTrends, Discovery,TWC-focusedof 17

  11. Overview of Processes Involved in Spin Transfer Collisions

    SciTech Connect (OSTI)

    Buttimore, N. H. [Trinity College, Dublin (Ireland)

    2008-04-30T23:59:59.000Z

    An outline is provided of methods for polarizing antiprotons that include the possible use of channelling in a bent crystal and also the technique of scattering off leptons or protons at a suitably small angle. In the method of channelling it is suggested that the angular dependence of the analysing power of the incident particle is cubic in the angle for single scattering in the crystal when this takes place within the region of electromagnetic hadronic interference as is most likely for channelled particles. Polarization transfer in the scattering of antiprotons off leptons or protons is discussed in addition where emphasis is laid on the angular integrals over spin observables appropriate for spin filtering.

  12. Identifying Callous-Unemotional Subtypes among Justice-Involved Youth

    E-Print Network [OSTI]

    Magyar, Melissa Sue

    2014-08-06T23:59:59.000Z

    will be discussed in greater detail later in this proposal. Is There More than One Type of Psychopath? Investigating Variants of Psychopathy The possible existence of psychopathy subtypes has been the focus of theory for decades (Karpman, 1941; McCord & Mc... significantly more borderline traits, irritability, social withdrawal, lack of assertiveness, major mental illness, and significantly poorer clinical functioning. However, in contrast to extant theories, secondary psychopaths were neither more impulsive nor...

  13. GC GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers3.pdf0-45.pdf0 Budget Fossil EnergyFull Text ManagementDOE REALGC GUIDANCE ON

  14. DOE Involvement in Consensus Negotiations for Energy Conservation Standards

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613PortsmouthBartlesvilleAbout »Department of2 DOE F 1300.2Million) GoDOE IDIQDepartment|

  15. Local employee honored for community involvement | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomy andTerms Loan Terms TheNaturalemployee honored for

  16. OREM continues involvement with workforce development program | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in ManyDepartment of Order No.of Energy OPCOPSAID|65: LNGOREMof

  17. Getting Involved in Manufacturing Day - College Educators Edition Webinar

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM Flash2011-12 OPAMGeneral Guidance on NEPAGeothermalRenewable EnergyGet|

  18. Microsoft Word - Number of Public Involvement Deliverables _2_.doc

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Gary L. Hirsch ProjectLyneis,NevadaNuclear14583TBD3,MAP

  19. OpenEI:Get Involved | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOfRoseConcernsCompany Oil andOpenEI CommunitydesignOpenEI:GeoTeam Jump

  20. Probative Investigation of the Thermal Stability of Wastes Involved in

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHA AdministrativeofDepartmentEnergyLoan

  1. Public Involvement in the Environmental Assessment Process | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHASeptember 2010 |ofDepartment ofPart 1021 |

  2. Central Plateau Principles Public Involvement Advice DETAILED BACKGROUND

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced. C o w l i t z C oCNMSStaff HighlightGroundwater Vadose Zonev0,

  3. Tri-Party Agreement Hanford Public Involvement Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesisAppliancesTrending: Metal Oxo Bonds PrintStatement

  4. Public Involvement and Communications Committee Summaries - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeedingTechnical News,Program90803| DepartmentPseudogaps,Point This is

  5. Workplace Charging Challenge Partner: JLA Public Involvement | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: SinceDevelopment | Department ofPartnershipsAngieTerriDepartmentDepartmentEnergy IDEXXJEAof

  6. Emergency Response to a Transportation Accident Involving Radioactive

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T,Office ofEnergyFinalEnergyEVProposed PenaltyEnergylinesDEPARTMENT

  7. RAPID/Best Practices/Public Involvement | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I GeothermalPotentialBiopowerSolidGenerationMethod JumpGeorgia: EnergyOnline Permitting Systems <

  8. TRI-PARTY AGREEMENT HANFORD PUBLIC INVOLVEMENT PLAN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesis of 2D Alloys &

  9. Draft Public Involvement Advice for Central Plateau Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField Campaign:INEA : Papers69Christopher FeckoDraftDraft- RAP/PICV0, 12/9/14

  10. Drum Involved in Idaho Incident Not Shippable to WIPP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField Campaign:INEA : Papers69ChristopherDrug-resistant TB Nature-inspired

  11. All projects in the Center involve multiple Co-PIs, with the majority of the projects involving Co-PIs from

    E-Print Network [OSTI]

    Eustice, Ryan

    Thrust I is developing the fundamental experimental and computational techniques for controlling on the Center website. Research in the Center The Center is Guided by an External Advisory Board Industry · Dr. Jeffrey Marks, Lam Research Inc. · Dr. Tim Sommerer, General Electric · Dr. Nick Fuller, IBM · Dr. Mark

  12. Corporate involvement in disaster response and recovery : an analysis of the Gujarat Earthquake

    E-Print Network [OSTI]

    Sayegh, Tracy, 1976-

    2004-01-01T23:59:59.000Z

    Disaster vulnerability is a serious issue in developing countries where globalization, development patterns, poverty and environmental degradation are placing more people at risk to natural disasters. Recent appeals for ...

  13. Application of the SCALE TSUNAMI Tools for the Validation of Criticality Safety Calculations Involving 233U

    SciTech Connect (OSTI)

    Mueller, Don [ORNL; Rearden, Bradley T [ORNL; Hollenbach, Daniel F [ORNL

    2009-02-01T23:59:59.000Z

    The Radiochemical Development Facility at Oak Ridge National Laboratory has been storing solid materials containing 233U for decades. Preparations are under way to process these materials into a form that is inherently safe from a nuclear criticality safety perspective. This will be accomplished by down-blending the {sup 233}U materials with depleted or natural uranium. At the request of the U.S. Department of Energy, a study has been performed using the SCALE sensitivity and uncertainty analysis tools to demonstrate how these tools could be used to validate nuclear criticality safety calculations of selected process and storage configurations. ISOTEK nuclear criticality safety staff provided four models that are representative of the criticality safety calculations for which validation will be needed. The SCALE TSUNAMI-1D and TSUNAMI-3D sequences were used to generate energy-dependent k{sub eff} sensitivity profiles for each nuclide and reaction present in the four safety analysis models, also referred to as the applications, and in a large set of critical experiments. The SCALE TSUNAMI-IP module was used together with the sensitivity profiles and the cross-section uncertainty data contained in the SCALE covariance data files to propagate the cross-section uncertainties ({Delta}{sigma}/{sigma}) to k{sub eff} uncertainties ({Delta}k/k) for each application model. The SCALE TSUNAMI-IP module was also used to evaluate the similarity of each of the 672 critical experiments with each application. Results of the uncertainty analysis and similarity assessment are presented in this report. A total of 142 experiments were judged to be similar to application 1, and 68 experiments were judged to be similar to application 2. None of the 672 experiments were judged to be adequately similar to applications 3 and 4. Discussion of the uncertainty analysis and similarity assessment is provided for each of the four applications. Example upper subcritical limits (USLs) were generated for application 1 based on trending of the energy of average lethargy of neutrons causing fission, trending of the TSUNAMI similarity parameters, and use of data adjustment techniques.

  14. Investigation of the absorption principle involved in the analyses and titrations performed in high frequency fields

    E-Print Network [OSTI]

    Griffin, James Hilton

    1940-01-01T23:59:59.000Z

    'csoioo of tho RIXl@F4wlltLI Wotan ~ e e ~ e s ~ ~ 9 IVe Reoooeiaa of ksidhaotd. a ReaetilRlo e e ~ e ~ ~ e e s ~ ~ e 18 IlioolllloiM Of PtN4Pit44iOG RSSNSO s ~ ~ e s e ~ ~ e e ~ RV VXs BioeueaSOS Of the QeteeuLnat4OO Of Water ill Cl'geode Ikgui4ee 59 VIXe... s e e e e ~ e e 58 Xi Contour Data for Lho Titration of ~roohlorio and Ditrie keide with 804%un F jll'oxide, ~ ~ ~ o i i ~ ~ ~ i 15 XI, Titration of Spdroohlorio kaid with Sodium Dpiroxido ~ i ~ 15 III ~ Titration of Sitrio koid with Sodiun...

  15. Involvement of peroxidases in the Medicago truncatula-Rhizobium meliloti symbiosis

    E-Print Network [OSTI]

    Subramanian, Latha

    2000-01-01T23:59:59.000Z

    The symbiotic interaction between legume plants and bacteria of the family Rhizobiaceae leads to the production of nitrogen fixing nodules on the plant. Nodule production is an expensive process and hence is highly regulated by the plant...

  16. Bayesian approaches to bilinear inverse problems involving spatial evidence : color constancy and blind image deconvolution

    E-Print Network [OSTI]

    Singh, Barun, 1982-

    2006-01-01T23:59:59.000Z

    This thesis examines two distinct but related problems in low-level computer vision: color constancy and blind-image deconvolution. The goal of the former is to separate the effect of global illumination from other properties ...

  17. An Exploratory Study of a Shared-Book Reading Intervention Involving Spanish-Speaking Latino Families 

    E-Print Network [OSTI]

    Vaquero, Juana

    2014-11-19T23:59:59.000Z

    on children’s oral language, CAP and narrative skills at short-term. Implications, limitations and directions for future research are discussed....

  18. Redox Characterization of Proteins Involved in the Mitochondrial Intermembrane Space Pathway

    E-Print Network [OSTI]

    Neal, Sonya Elina

    2013-01-01T23:59:59.000Z

    Bardwell. 1999. Oxidative protein folding is driven by theRedox regulation of protein folding in the mitochondrial2008. Disulfide-linked protein folding pathways. Annu. Rev.

  19. Faculty Research Interests These School of Nursing faculty members are involved in innovative, timely research.

    E-Print Network [OSTI]

    Acton, Scott

    , breastfeeding, maternal responsiveness and attachment, postpartum depression, instrument development, technology on quality of care and clinical outcomes in rural hospitals · Barbero, Edie Grief related topics · Boitnott and Practice; Clinical Indicators of Erythema in Darkly Pigmented Skin · Brodie, Barbara History of health care

  20. Cache Probabilistic Modeling for Basic Sparse Algebra Kernels involving Matrices with a Non Uniform Distribution

    E-Print Network [OSTI]

    Fraguela, Basilio B.

    ´ia (CICYT) under project TIC96-1125, Xunta de Galicia under Project XUGA20605B96 p pp ppp ppp ppp pp p pp ppp p ppp pppppp ppp pppppp pp p pp ppp p ppp pppppp ppp pppppp pp p pp ppp p pppppp ppp pppppp ppp pp ppp p pp p pppppp ppp pppppp ppp pp ppp p pp p pppppp ppp pppppp ppp pp p pp p pp p ppp ppp ppp ppp

  1. Involvement of Mesenchymal Stem Cells in Cancer Progression andMetastases

    E-Print Network [OSTI]

    Wu, Jian

    2015-01-01T23:59:59.000Z

    the response of acute lymphoblastic leukemia cells toASNS) in acute lymphoblastic leukemia (ALL) cells lend themLIST OF ABBREVIATIONS ALL acute lymphoblastic leukemia ASNS

  2. Identification and analysis of cellular factors involved in v-Abl transformation of B lineage cells

    E-Print Network [OSTI]

    Yu, Jason

    2013-01-01T23:59:59.000Z

    children with acute lymphoblastic leukemia. Blood 97, 3925-B-cell lineage acute lymphoblastic leukemia. Cancer Res. 70,the response of acute lymphoblastic leukemia cells to

  3. Supporting information For `Cofactors involved in light-driven charge separation in photosystem I identified by

    E-Print Network [OSTI]

    van Stokkum, Ivo

    angle with respect to the probe beam. A phase-locked chopper at 500 Hz ensured that every other shot) with a power of 100 nJ focused to a spot of ~150 micrometer in diameter for excitation. A moveable delay line the sample is excited and an absorbance difference spectrum can be calculated. To ensure a fresh spot

  4. Local government involvement in long term resource planning for community energy systems. Demand side management

    SciTech Connect (OSTI)

    Not Available

    1992-03-01T23:59:59.000Z

    A program was developed to coordinate governmental, research, utility, and business energy savings efforts, and to evaluate future potential actions, based on actual field data obtained during the implementation of Phase I of the State Resource Plan. This has lead to the establishment of a state conservation and energy efficiency fund for the purpose of establishing a DSM Program. By taking a state wide perspective on resource planning, additional savings, including environmental benefits, can be achieved through further conservation and demand management. This effort has already blossomed into a state directive for DSM programs for the natural gas industry.

  5. Local government involvement in long term resource planning for community energy systems

    SciTech Connect (OSTI)

    Not Available

    1992-03-01T23:59:59.000Z

    A program was developed to coordinate governmental, research, utility, and business energy savings efforts, and to evaluate future potential actions, based on actual field data obtained during the implementation of Phase I of the State Resource Plan. This has lead to the establishment of a state conservation and energy efficiency fund for the purpose of establishing a DSM Program. By taking a state wide perspective on resource planning, additional savings, including environmental benefits, can be achieved through further conservation and demand management. This effort has already blossomed into a state directive for DSM programs for the natural gas industry.

  6. Non-Muscle oL-DystroglycanIs Involved in Epithelial Development

    E-Print Network [OSTI]

    Campbell, Kevin P.

    , ~Oxana Ibraghimov-Beskrovnaya, ~Steven L. Roberds, ~ Kevin P. Campbell, ~and Peter Ekblom* Departments receptors for basement membrane compo- nents such as laminins (Hynes, 1992; Timpl and Brown, 1994), and few

  7. Response and Notification Procedures for Data Breaches Involving Personally Identifiable Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-10-09T23:59:59.000Z

    This Notice concerns actions to address data breaches of personally identifiable information that is collected, processed or maintained by DOE. Extended by DOE N 251.73 until 1-9-09. No cancellation.

  8. Differing Professional Opinions for Technical Issues Involving Environment, Safety and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29T23:59:59.000Z

    The Order establishes the DOE Differing Professional Opinion process for employees to raise technical concerns related to environment, safety, and health which cannot be resolved using routine processes. Cancels DOE P 442.1 and DOE M 442.1-1.

  9. Abstract--This paper addresses the problem of controlling wind energy conversion systems (WECS) which involve

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Abstract-- This paper addresses the problem of controlling wind energy conversion systems (WECS-inverter. The goal of control is to maximize wind energy extraction and this needs letting the wind turbine rotor wind energy extraction) only for one wind speed value depending on the considered value of turbine

  10. Management involves coordinating a group of people to accomplish a goal. The Management program at

    E-Print Network [OSTI]

    to students in all areas of business. Scholarships range from $250 to the $44,000 Clay Barton Scholarship management, and personal selling. The W. Frank Barton School of Business also offers four master's degree

  11. Marketing involves the design, pricing, promotion and distribution of goods and services for consumers.

    E-Print Network [OSTI]

    with the Elliott School of Communication, a new minor in Personal Selling is now available. Personal Selling to the $44,000 Clay Barton Scholarship. Admission When you choose to major in Marketing, you are admitted

  12. -Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

    E-Print Network [OSTI]

    Giri, Ranjit K.

    and PECAM-1 RANJIT GIRI,1 YAMIN SHEN,1 MONIQUE STINS,2 SHI DU YAN,3 ANN MARIE SCHMIDT,3 DAVID STERN,3 KWANG Giri, Ranjit, Yamin Shen, Monique Stins, Shi Du Yan, Ann Marie Schmidt, David Stern, Kwang-Sik Kim of the Dutch type (HCHWA-D) (28). The A , a heterogeneous, 39- to 43-amino acid peptide, the major constituent

  13. Investigations of the Fundamental Surface Reactions Involved in the Sorption and Desorption of Radionuclides

    SciTech Connect (OSTI)

    Czerwinski, Ken; Heske, Clemens; Moser, Duane; Misra, Mnoranjan; McMillion, Glen

    2011-04-20T23:59:59.000Z

    Models for describing solution- and surface-phase reactions have been used for 30 years, but only recently applicable to complex surfaces. Duff et al., using micro-XANES, found that Pu was concentrated on Mn-oxide and smectite phases of zeolitic tuff, providing an evaluation of contaminant speciation on surfaces for modeling. Experiments at Los Alamos demonstrated that actinides display varying surface residence time distributions, probably reflective of mineral surface heterogeneity. We propose to investigate the sorption/desorption behavior of radionuclides from mineral surfaces, as effected by microorganisms, employing isolates from Nevada Test Site deep alluvium as a model system. Characterizations will include surface area, particle size distribution, x-ray diffraction (XRD), microprobe analysis, extractions, and microbiology. Surface interactions will be assessed by electron spectroscopy (XPS), x-ray absorption fine structure spectroscopy (XAFS), X-ray emission spectroscopy, transmission electron microscopy (TEM) and Scanning electron microscopy (SEM). Desert Research Institute (DRI), University of Nevada, Reno (UNR), and University of Nevada, Las Vegas (UNLV) researchers will collaborate to enhance scientific infrastructure and the understanding of contaminant behavior on surfaces, with broader implications for the management of DOE sites.

  14. March 2005 Page 1 of 2 CDCResearchInvolvingRadiationReleasesfromtheIdahoNational

    E-Print Network [OSTI]

    iodine-129 and -131, cesium-137, strontium-90, and noble gases including krypton-88. The body organs by the INL Environmental Dose Reconstruction document search to determine which contaminants and exposure

  15. Risk assessment involving the land disposal of animal waste on Central Texas dairies

    E-Print Network [OSTI]

    Lee, Thomas Chadwick

    1999-01-01T23:59:59.000Z

    Land disposal of animal waste is an increasing problem for dairies in central Texas Once isolated, many producers now and themselves surrounded by towns and subdivisions. Many of these new neighbors are showing an increasing concern about potential...

  16. Self-determination and student involvement in standards-based reform

    E-Print Network [OSTI]

    Wehmeyer, Michael L.; Field, Sharon; Doren, Bonnie; Jones, Bonnie; Mason, Christine

    2004-01-01T23:59:59.000Z

    Promoting self-determination has become ‘best practice’ in the education of students with disabilities. We synthesize the decade's work in this area as a foundation for considering issues pertaining to promoting self-determination in light...

  17. Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance

    E-Print Network [OSTI]

    Whalen, Kristen Elizabeth

    2008-01-01T23:59:59.000Z

    Understanding how organisms deal with potentially toxic or fitness-reducing allelochemicals is important for understanding patterns of predation and herbivory in the marine environment. The ability of marine consumers to ...

  18. Chemical Force Spectroscopy in Heterogeneous Systems: Intermolecular Interactions Involving Epoxy Polymer, Mixed

    E-Print Network [OSTI]

    Prentiss, Mara

    , lubrication, adsorption, biological adhesion, or susceptibility of interfaces to changes in environmental conditions.1,2 In many engineering, chemical, or biological processes, the behavior of these inter- faces.g. viscoelastic dissipation of energy) are extremely valuable. In the present work, we attempt direct experimental

  19. Understanding Postranslational Modifications Involved in Adi3 Programmed Cell Death Signaling 

    E-Print Network [OSTI]

    Avila Pacheco, Julian Ricardo, 1983-

    2012-10-15T23:59:59.000Z

    by which Adi3 regulates PCD, we identified Adi3 interacting partners in a Y2H screen. Here, I describe the interaction of Adi3 with two interacting partners identified: the Sucrose Non-fermenting (SNF1) kinase complex (SnRK) which is a eukaryotic master...

  20. Native American fishery issues: Hanford involvement in evaluation of the Zone 6 fishery

    SciTech Connect (OSTI)

    Abernethy, C.S.; Neitzel, D.A. (Pacific Northwest Lab., Richland, WA (United States)); Strom, G. (Yakima Indian Nation, Toppenish, WA (United States))

    1992-07-01T23:59:59.000Z

    Native American fishers are concerned about the deteriorating quality of salmon and other fish caught from the Columbia River. They fear salmon are not healthy and that eating the fish could Jeopardize the health of Native Americans. In 1991, the Pacific Northwest Laboratory (PNL). with the assistance of the Yakima Indian Nation (YIN). monitored the salmon and steelhead fishery in the lower Columbia River (Zone 6 fishery). PNL biologists set up a hot-line'' for Native American fishers to call if they caught fish they suspected were diseased or contaminated. Fish reported to the hot-line were examined by a fish disease pathologist. Additionally. PNL and YIN staff reviewed water-quality data of the lower Columbia River. Water-quality data collected from 1949 through 1990. Results are described.

  1. Applying Machine Learning Methods to Suggest Network Involvement and Functionality of Genes in Saccharomyces cerevisiae

    E-Print Network [OSTI]

    Amthauer, Heather A.

    2008-10-10T23:59:59.000Z

    Elucidating genetic networks provides the foundation for the development of new treatments or cures for diseased pathways, and determining novel gene functionality is critical for bringing a better understanding on how an ...

  2. Possible causes of reddish discoloration of urine ("red water") as it involves cattle

    E-Print Network [OSTI]

    Lynd, Frederick Theodore

    1959-01-01T23:59:59.000Z

    produces a severe hssoglobinaaia, uhich is the result of hesolysis of circulating red blood cells by action of tosins or nitro?organisns, the free pageant srceeds the capacity of the reticulo-endothslial systaa ~ nd the henoglobfn is encreted... dilated with a bile snd the walls thickened With fibrous connective tissue. Otaat areas of hepatic tissue in all, stages of necrosis were reticulated with enlarged prominent gupffer cells containing yellow granular pigment. The spleen showed reticulo...

  3. Hydrogenolysis Of 5-Carbon Sugars, Sugar Alcohols And Compositions For Reactions Involving Hydrogen

    DOE Patents [OSTI]

    Werpy, Todd A. (West Richland, WA); Frye, Jr., John G. (Richland, WA); Zacher, Alan H. (Kennewick, WA); Miller, Dennis J. (Okemos, MI)

    2004-01-13T23:59:59.000Z

    Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 5-carbon sugar, sugar alcohol, or lactic acid are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol. A process for the synthesis of PG from lactate or lactic acid is also described.

  4. Hydrogenolysis of 5-carbon sugars, sugar alcohols, and other methods and compositions for reactions involving hydrogen

    DOE Patents [OSTI]

    Werpy, Todd A [West Richland, WA; Zacher, Alan H [Kennewick, WA

    2002-11-12T23:59:59.000Z

    Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 5-carbon sugar, sugar alcohol, or lactic acid are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol. A process for the synthesis of PG from lactate or lactic acid is also described.

  5. Responses of Magnocellular Neurons to Osmotic Stimulation Involves Coactivation of Excitatory and Inhibitory Input: An

    E-Print Network [OSTI]

    Feng, Jianfeng

    of normal rats respond to intra- venous infusions of hypertonic saline with gradual, linear in- creases response to such infusions. We show that a simple computational model can reproduce these responses well, but only if it is assumed that hypertonic infusions coacti- vate excitatory and inhibitory synaptic inputs

  6. Introduction: The University of Connecticut Health Center is actively involved in working with animals. In

    E-Print Network [OSTI]

    Oliver, Douglas L.

    an allergic reaction to animals. If you are experiencing hives, a runny nose or eyes, coughing or shortness

  7. Identification and Characterization of Proteins Involved in Nuclear Organization Using Drosophila GFP Protein

    E-Print Network [OSTI]

    Corces, Victor G.

    , Edward Ramos1 , Maza R. Tchedou3 , Gilbert Acosta1 , Mark Araujo1 , Stuart Cushing4 , Gabriel Duffy3 Takenaka1 , Eduardo Torre1 , Jarvis Veira6 , Kim Vu2 , William Wagstaff6 , Ashley M. Wood1 , Karen Wu1

  8. Factors affecting the recovery of petroleum in projects involving the injection of liquefied petroleum gases (LPG)

    E-Print Network [OSTI]

    Graham, Gerry A

    1961-01-01T23:59:59.000Z

    , CONCLUSIONS 6. ACKNOWLEDGEMENT 7. APPENDIX 8. REFERENCES 9. BIBLIOGRAPHY 25 26 33 337588 LIST OF FIGURES AND TABLES Figures Flow Diagram of Displacement Equipment Oil Production vs Slug Size for various injection rates , (Sand Coluxnn No. 1) 15... Oil Production vs. Slug Size for various injection rates , (Sand Column No. 2) 16 Oil Production vs Slug Size for various injection rates , (Sand Column No. 3) 17 Oil Production vs Slug Size for various injection rates , (Sand Column No. 4) 18...

  9. p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair

    E-Print Network [OSTI]

    Lin, Yu-Li

    The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that ...

  10. Bc Meson Formfactors and Bc-->PV Decays Involving Flavor Dependence of Transverse Quark Momentum

    E-Print Network [OSTI]

    Rohit Dhir; R. C. Verma

    2009-01-08T23:59:59.000Z

    We present a detailed analysis of the Bc form factors in the BSW framework, by investigating the effects of the flavor dependence on the average transverse quark momentum inside a meson. Branching ratios of two body decays of Bc meson to pseudoscalar and vector mesons are predicted.

  11. Parent Engagement 10 Great Ways for Parents and Families to Get Involved

    E-Print Network [OSTI]

    , Dubai and Pune, India. Contact Kathy Duplessis at 713-348-4619 or kdup@rice.edu for more details. 6-edge scholar- ship on some of the most important public policy challenges of our time, Rice's Baker Institute for Public Policy hosts several member- ship events with national and international leaders and dignitaries

  12. Synthesis, Reactivity, and Catalytic Behavior of Iron/Zinc-Containing Species Involved in Oxidation of

    E-Print Network [OSTI]

    symmetry at 223 K. The filtrate of the reduction of 1 with zinc in neat pyridine, when exposed to dioxygen, toluene, cis-stilbene, and pyridine mediated by the system 1 (or 2-4)/Zn/O2 in py/AcOH (10:1

  13. Research Profile The LTNT is involved in research of interfacial phenomena in

    E-Print Network [OSTI]

    Sandoghdar, Vahid

    The first on-demand and maskless production of 2D and 3D-structures at the nanoscale is currently being.g. for nanoscale pressure sensors catalytic reactions on nanoparticles for energy conversion­ devices; we flow and electrochemistry occurring in the porous anode. #12;Functionalization by Printing Beyond Color

  14. Objective Rejection?: The Effects of Agreement and Involvement on Message Quality Evaluation

    E-Print Network [OSTI]

    Hall, Jeffrey A.; Householder, Brian J.

    2007-01-01T23:59:59.000Z

    To extend argument quality research, this article explores the effects of agreement and issue im- portance on argument quality assessment for eight different topic areas to explore whether there is systematic bias in the evaluation of an argument...

  15. Probabilities of delayed processes for nuclei involved in the r-process

    SciTech Connect (OSTI)

    Panov, I. V., E-mail: Igor.Panov@itep.ru [Institute for Theoretical and Experimental Physics (Russian Federation); Korneev, I. Yu.; Lutostansky, Yu. S. [National Research Center Kurchatov Institute (Russian Federation)] [National Research Center Kurchatov Institute (Russian Federation); Thielemann, F.-K. [University of Basel, Institute of Physics (Switzerland)] [University of Basel, Institute of Physics (Switzerland)

    2013-01-15T23:59:59.000Z

    Delayed fission, along with induced and spontaneous fission, is responsible for the suppression of the production of superheavy elements both during the r-process and after its completion. Beta-decay strength functions are required for calculating delayed fission. In the present study, respective strength functions are calculated by relying on the theory of finite Fermi systems and by predominantly employing nuclear masses and fission barriers predicted by a generalized Thomas-Fermi model. The probabilities for delayed fission and for the emission of delayed neutrons are calculated for a number of isotopes. On the basis of calculations performed in order to determine the probabilities for delayed processes, it is shown that some of the delayed-fission probabilities calculated thus far were substantially overestimated. The application of these new results to calculating the r-process may change substantially both the r-process path and the yields of superheavy nuclei.

  16. Metal Catalyzed Formation of Aliphatic Polycarbonates Involving Oxetanes and Carbon Dioxide as Monomers 

    E-Print Network [OSTI]

    Moncada, Adriana I.

    2011-08-08T23:59:59.000Z

    Catalysts for Ring-Opening Polymerization of Six-Membered Cyclic Carbonates .......................................................................... 8 Aliphatic Polycarbonates from Oxetanes and Carbon Dioxide...... 15 Metal Salen Complexes... in TCE. Slope = -8910.7 with R2 = 0.9997 ......................................................................................... 56 II-15 1H NMR spectrum in CDCl3 of poly(TMC) obtained by way of oxetane/CO2 in the presence of (salen...

  17. Physical processes involved in strip electrode welding using the method of slatted splicing

    SciTech Connect (OSTI)

    Bushma, V. O. [Moscow State Technological University 'Stankin' (Russian Federation)

    2010-12-15T23:59:59.000Z

    Physical processes that take place in a strip electrode during welding using the slatted splicing technique are considered. Flowing of the welding current in the electrode is shown to be the key process which determines electrode heating and melting. Technological receipts are proposed that allow obtaining high-quality welds by the method of slatted splicing.

  18. A system theoretic safety analysis of U.S. Coast Guard aviation mishap involving CG-6505

    E-Print Network [OSTI]

    Hickey, Jon (Jon Patrick)

    2012-01-01T23:59:59.000Z

    During a 22-month period, between 2008 and 2010, the U.S. Coast Guard experienced seven Class-A aviation mishaps resulting in the loss of 14 Coast Guard aviators and seven Coast Guard aircraft. This represents the highest ...

  19. A novel instrument for quantitative nanoanalytics involving complementary X-ray methodologies

    SciTech Connect (OSTI)

    Lubeck, J.; Beckhoff, B.; Fliegauf, R.; Holfelder, I.; Hoenicke, P.; Mueller, M.; Pollakowski, B.; Reinhardt, F.; Weser, J. [Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin (Germany)

    2013-04-15T23:59:59.000Z

    A novel ultra-high vacuum instrument for X-ray reflectometry and spectrometry-related techniques for nanoanalytics by means of synchrotron radiation has been constructed and commissioned. This versatile instrument was developed by the Physikalisch-Technische Bundesanstalt, Germany's national metrology institute, and includes a 9-axis manipulator that allows for an independent alignment of the samples with respect to all degrees of freedom. In addition, a rotational and translational movement of several photodiodes as well as a translational movement of an aperture system in and out of the beam is provided. Thus, the new instrument enables various analytical techniques based on energy dispersive X-ray detectors such as reference-free X-ray fluorescence analysis (XRF), total-reflection XRF, grazing-incidence XRF in addition to optional X-ray reflectometry measurements or polarization-dependent X-ray absorption fine structure analyses. With this instrument samples having a size of up to 100 mm Multiplication-Sign 100 mm can be analyzed with respect to their mass deposition, elemental or spatial composition, or the species in order to probe surface contamination, layer composition and thickness, the depth profile of matrix elements or implants, the species of nanolayers, nanoparticles or buried interfaces as well as the molecular orientation of bonds. Selected applications of this advanced ultra-high vacuum instrument demonstrate both its flexibility and capability.

  20. herbivore-or wound-induced vocabularies have been modified by silencing genes involved

    E-Print Network [OSTI]

    Klee, Harry J.

    (Fig. 1). Mutants whose perception of specific VOCs is impaired (``deaf'' plants) represent another. R. Karban, J. Maron, Ecology 83, 1209 (2002). 16. M. Heil, I. T. Baldwin, Trends Plant Sci. 7, 61

  1. A Role-involved Conditional Purpose-based Access Control Model

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    control to achieve database security and available in database management systems. The structure helps. Access control is the process of limiting access to the re- sources of a system only to authorized users a secure privacy policy to remove the fear of customers. Thus in an internal management system, a reliable

  2. Arabidopsis SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in

    E-Print Network [OSTI]

    Jacobsen, Steve

    91125 Communicated by Bernard 0. Phinney, University of California, Los Angeles, CA, May 16, 1996 in maize, wheat, and Arabidopsis. The second group, the "slender" mutants, have a recessive overgrowth

  3. From Isolation to Involvement: Adapting Machine Creativity Software to Support Human-Computer Co-Creation

    E-Print Network [OSTI]

    Toivonen, Hannu

    as a creative assistant for a human poet, pro- ducing draft poems that the poet could use as inspiration or raw

  4. Employee Involvement and Pay at U.S. and Canadian Auto Suppliers

    E-Print Network [OSTI]

    Helper, Susan; Levine, David I.; Bendoly, Elliott

    2000-01-01T23:59:59.000Z

    For example at Industrial Strainer, workers contributed onone company (Industrial Strainer) had a prolonged strikeas noted in the Industrial Strainer and Foamade examples

  5. A product involving the $\\beta$-family in stable homotopy theory

    E-Print Network [OSTI]

    Liu, Xiugui

    2009-01-01T23:59:59.000Z

    In the stable homotopy groups $\\pi_{q(p^n+p^m+1)-3}(S)$ of the sphere spectrum $S$ localized at the prime $p$ greater than three, J. Lin constructed an essential family $\\xi_{m,n}$ for $n \\geq m + 2 >5$. In this paper, the authors show that the composite $\\xi_{m,n}\\beta_{s}\\in \\pi_{q(p^n+p^m+sp+s)-5}(S)$ for $2 \\leq s < p$ is non-trivial, where $q=2(p-1)$ and $\\beta_s \\in \\pi_{q(sp+s-1)-2}(S)$ is the known $\\beta$-family. We show our result by explicit combinatorial analysis of the (modified) May spectral sequence.

  6. Use of Science in Gulf of Mexico Decision Making Involving Climate Change

    E-Print Network [OSTI]

    Vedlitz, Arnold; Alston, Letitia T.; Laska, Shirley B.; Gramling, Robert B.; Harwell, Mark A.; Worthen, Helen D.

    2007-01-01T23:59:59.000Z

    . The endpoints chosen were: water (quality and quantity), ecosystems, and infrastructure. While the three research locations all face water, ecosystem and infrastructure issues, the specifics of these issues differ across the locations. The four stressors... of Locations, Endpoints and Stressors The team selected six endpoints and four stressors to focus the research. The endpoints chosen were infrastructure and ecosystems in the Western Gulf, infrastructure, ecosystems and water in the Central Gulf...

  7. The Challenge of Democratization in Nigeria: Involvement or Alienation of the Military

    E-Print Network [OSTI]

    Amadife, Emmanuel N.

    1992-01-01T23:59:59.000Z

    71108. 20x.arry Diamond. "Nigeria in Search of Democracy,"Impending Demise of Nigeria's Forthcoming Third Republic,"system that has governed Nigeria for the most part since

  8. Investigation of factors involved in a proposed method of estimating runoff from small drainage areas

    E-Print Network [OSTI]

    Riley, Boyd Tolbert

    1962-01-01T23:59:59.000Z

    of assumpt1ons inoluded in the proposed method that oould be in- valM, However, these assumptions were inoluded in other solu tions of th1s problem? After a theoretioal basis ?as formulated, the proposed method seemed to be valM? Ths following proosdure... it was learned that only a few gaged drainage areas existed in Texas that were less than twenty square m1los in area+ After being oonf ranted with this situation, it was deoMed to reinvest%fate the Wpp and reoord sash drainage basin that was comparatively...

  9. Isospin aspects in nuclear reactions involving Ca beams at 25 MeV/nucleon

    SciTech Connect (OSTI)

    Lombardo, I., E-mail: ilombardo@lns.infn.it; Agodi, C.; Alba, R.; Amorini, F.; Anzalone, A. [INFN Laboratori Nazionali del Sud (Italy); Auditore, L. [Universita di Messina, and INFN-Gr. Coll. Messina, Dipartimento di Fisica (Italy); Berceanu, I. [Institute for Physics and Nuclear Engineering (Romania); Cardella, G. [INFN, Sezione di Catania (Italy); Cavallaro, S. [INFN Laboratori Nazionali del Sud (Italy); Chatterjee, M. B. [Saha Institute of Nuclear Physics (India); Filippo, E. De [INFN, Sezione di Catania (Italy); Di Pietro, A.; Figuera, P. [INFN Laboratori Nazionali del Sud (Italy); Giuliani, G.; Geraci, E.; Grassi, L. [Dipartimento di Fisica e Astronomia Universita di Catania (Italy); Grzeszczuk, A. [University of Silesia, Institute of Physics (Poland); Han, J. [INFN Laboratori Nazionali del Sud (Italy); La Guidara, E. [INFN, Sezione di Catania (Italy); Lanzalone, G. [INFN Laboratori Nazionali del Sud (Italy); and others

    2011-11-15T23:59:59.000Z

    Isospin dependence of dynamical and thermodynamical properties observed in reactions {sup 40}Ca+ {sup 40,48}Ca and {sup 40}Ca + {sup 46}Ti at 25 MeV/nucleon has been studied. We used the CHIMERA multi-detector array. Strong isospin effects are seen in the isotopic distributions of light nuclei and in the competition between different reaction mechanisms in semi-central collisions. We will show also preliminary results obtained in nuclear collision {sup 48}Ca + {sup 48}Ca at 25MeV/nucleon, having very high N/Z value in the entrance channel (N/Z = 1.4). The enhancement of evaporation residue production confirms the strong role played by the N/Z degree of freedom in nuclear dynamics.

  10. Optical model potentials involving loosely bound p-shell nuclei around 10 MeV/nucleon 

    E-Print Network [OSTI]

    Trache, L.; Azhari, A.; Clark, HL; Gagliardi, Carl A.; Lui, YW; Mukhamedzhanov, AM; Tribble, Robert E.; Carstoiu, F.

    2000-01-01T23:59:59.000Z

    model with real effective interactions the absorption is accounted for phenomenologically by adding an imaginary potential of the same shape as the real part U~r !5~NV1iNW!V fold~r !, ~15! whereas for the cases when the effective interaction also... reanalyzed all our elastic scattering data using double folding potentials obtained with the six effective interactions outlined above. The renormalization constants NV and NW were further adjusted to fit the elastic scattering data using Eq. ~15...

  11. Oxidative stress in K562 cells differentiation 1 OXIDATIVE STRESS INVOLVEMENT IN CHEMICALLY-INDUCED

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ) and doxorubicin (DOX). When used at subtoxic concentration, these drugs induce the overexpression of erythroid with BA, ACLA and DOX lead to a decrease in reduced glutathione and antioxidant enzymes (glutathione peroxidase, glutathione reductase, CuZn superoxide dismutase (SOD) and catalase). In addition, DOX increased

  12. Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice*S

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    damage in humans and experimental ani- mals, but the mechanism(s) remain unclear. We investigated whether, Cleveland, Ohio 44106 Exposure to bright light can cause visual dysfunction and ret- inal photoreceptor­7) can accumulate as a consequence of aging (8). Under experimental conditions, these compounds can

  13. Creating New Leaders: Youth Involvement in Community Activism in South Africa

    E-Print Network [OSTI]

    Reed, Amber R

    2011-01-01T23:59:59.000Z

    July 27, 2009, Cape Town, South Africa. 23 Sipho,participant, July 27, 2009, Cape Town, South Africa. 245, 2009, Qumbu, South Africa. 25 Paki, youth participant,

  14. Methyl viologen mediated oxidation-reduction across dihexadecylphosphate vesicles involves transmembrane diffusion

    SciTech Connect (OSTI)

    Patterson, B.C.; Thompson, D.H.; Hurst, J.K.

    1988-05-25T23:59:59.000Z

    Numerous reports have appeared describing oxidation-reduction across bilayer membranes. Mechanisms proposed for specific systems include the following: (i) electron tunneling across the hydrocarbon barrier between interfacially bound redox partners, (ii) molecular diffusion of bound redox components across the barrier, and (iii) formation of barrier-penetrating aggregates, or electron-conducting channels, across the bilayer. Nonetheless, the actual reaction mechanisms remain obscure due to the general unavailability of transverse diffusion rates, possible loss of compartmentation of reactants, particularly in photochemical systems, and the ambiguities inherent in deducing reaction mechanisms from rate data, which form the primary evidence in most systems studied. The reactions of dihexadecylphosphate (DHP) vesicle-bound methyl viologen (MV/sup 2 +/) describes in this report are unique in allowing deduction of molecular details of a transmembrane redox event from the product composition and microphase distribution. Specifically, they have found that MV/sup 2 +/ bound at the outer vesicle interface mediates reduction of inner-localized MV/sup 2 +/ by dithionite ion in bulk solution in a manner that requires comigration of MV/sup +/ with the electron transferred across the membrane barrier.

  15. Ab initio characterization of the conical intersections involved in the photochemistry of phenol

    SciTech Connect (OSTI)

    Vieuxmaire, Olivier P. J.; Domcke, Wolfgang [Department of Chemistry, Technische Universitaet Muenchen, D-85747 Garching (Germany); Lan, Zhenggang [Max-Planck-Institut fuer Kohlenforschung, D-45470 Muelheim an der Ruhr (Germany); Sobolewski, Andrzej L. [Institute of Physics, Polish Academy of Sciences, PL-02668 Warsaw (Poland)

    2008-12-14T23:59:59.000Z

    The nature of the vibronic interactions between the {sup 1}{pi}{pi}* (A{sup '}), the {sup 1}{pi}{sigma}* (A{sup ''}), and the S{sub 0} (A{sup '}) states at the CI{sub {pi}}{sub {pi}}{sub */{pi}}{sub {sigma}}{sub *} and CI{sub {pi}}{sub {sigma}}{sub */{pi}}{sub {pi}} conical intersections has been investigated by accurate ab initio calculations. Potential energy surfaces have been constructed at the complete-active-space self-consistent-field and multireference configuration-interaction (MRCI) levels of theory along each of the ten normal coordinates of A{sup ''} symmetry that potentially can be coupling modes at these conical intersections. The OH torsion was found to be by far the strongest coupling mode in each case. As for benzene, a 'channel three' radiationless decay mechanism associated with a prefulvenic conical intersection, CI{sub pref}, was found to exist in phenol. The reaction path connecting the prefulvenic form of phenol with the minimum-energy structure of the S{sub 1} state was computed at different levels of theory. The barrier to be overcome for the opening of the prefulvenic decay channel is estimated as 6370 cm{sup -1} at the MRCI level, that is, about 2300 cm{sup -1} above the energy of CI{sub {pi}}{sub {pi}}{sub */{pi}}{sub {sigma}}{sub *}. With sufficient excess energy in the S{sub 1} state, the prefulvenic decay mechanism can be in competition with the hydrogen detachment process.

  16. Four-photon spectroscopy of ultrathin nickel films involving picosecond biharmonic pumping

    SciTech Connect (OSTI)

    Petnikova, V M; Rudenko, K V; Shuvalov, Vladimir V [International Laser Center, M. V. Lomonosov Moscow State University, Moscow (Russian Federation)

    1999-07-31T23:59:59.000Z

    Ultrathin (5 - 25 nm thick) nickel films were investigated experimentally by the picosecond biharmonic pumping method. Characteristic side resonances in the wing of the dependence of the self-diffraction efficiency on the frequency detuning of the biharmonic pumping components were observed. A model of the electronic part of the cubic nonlinear susceptibility was constructed. It takes into account the real structure of the spectrum of the electronic states of nickel, its quantum-size renormalisation and spin splitting, interband and intraband relaxation, as well as selection rules for the electronic transitions. For interband polarisation relaxation times T{sub 2} > 300 fs, a qualitative agreement was obtained between the calculated relationships and the experimental data. In the frequency-degenerate case, points at which the nonlinear response should be absent were found on the frequency scale. (this issue is dedicated to the memory of s a akhmanov)

  17. Search for neutrinoless tau decays involving pi(0) or eta mesons

    E-Print Network [OSTI]

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan

    1997-08-01T23:59:59.000Z

    We have searched for lepton flavor violating decays of the tau lepton using final states with an electron Or a muon and one or two pi(0) or eta mesons but no neutrinos. The data used in the search were collected with the CLEO II detector...

  18. Design of Novel Electron-Rich Organometallic Frameworks Involving Metal-Isocyanide Junctions

    E-Print Network [OSTI]

    Maher, Tiffany Rene

    2009-01-01T23:59:59.000Z

    Aromatic diisocyanides are extensively employed as building blocks in coordination and surface chemistry as charge transport mediators for nanotechnology applications. The first diisocyanoarene-bridged bimetallate system, [{(CO)5V}2(?-CNC6Me4NC)]2...

  19. Machining dynamics and stability analysis in longitudinal turning involving workpiece whirling

    E-Print Network [OSTI]

    Dassanayake, Achala Viomy

    2009-06-02T23:59:59.000Z

    to the machining surface to be three-dimensionally established as functions of spindle speed, instantaneous DOC, rate of material removal and whirling. Excluding workpiece vibrations from the cutting model is found improper. A rich set of nonlinear behaviors...

  20. Identification of ubiad1 as a gene involved in cardiovascular homeostasis and development

    E-Print Network [OSTI]

    Hegarty, Jeffrey Miles

    2011-01-01T23:59:59.000Z

    gene causes defects of bioenergetics and de novo pyrimidineparticipate in cardiac bioenergetics (Kumar et al. , 2009),defects affecting bioenergetics (López- Martín et al. ,