National Library of Energy BETA

Sample records for involvement involvement involvement

  1. Parent Involvement

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10

    To be successful, a 4-H program must have parent involvement. Although 4-H leaders and Extension agents may interest young people in becoming members, they need the parents' goodwill and support to keep them interested, ...

  2. Policy on Programs Involving Minors Policy on Programs Involving

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Programs Involving Minors 6/4/2014 Policy on Programs Involving Minors I. Purpose in University-sponsored activities that take place off campus. This policy applies to University or facilities that are operated or sponsored by third parties. This policy provides program registration

  3. RESEARCH OR TEACHING INVOLVING ANIMALS

    E-Print Network [OSTI]

    Victoria, University of

    Page 1 RESEARCH OR TEACHING INVOLVING ANIMALS University Policy No: RH8110 Classification: Research Approving Authority: Vice-President Research Effective date: June, 2014 Supersedes: December, 2010 Last for Conducting Research or Teaching Involving Animals Animal Care Committee Terms of Reference PURPOSE 1

  4. Some Ramsey Problems Involving Triangles -

    E-Print Network [OSTI]

    Radziszowski, Stanislaw P.

    Some Ramsey Problems Involving Triangles - Computational Approach Stanislaw Pawel Radziszowski Department of Computer Science Rochester Institute of Technology, NY ramsey@dimacs, 28 may 2009 1/40 #12;Outline - Triangles Everywhere or avoiding K3 in some/most colors 1 Ramsey Numbers - Two Colors Some known

  5. Radiological science involves technologists use

    E-Print Network [OSTI]

    Sibille, Etienne

    English Composition II Mathematics MATH 0110 Fundamentals of Mathematics THE HUMAN EXPERIENCE Students new Clinical Experience Radiographic Procedures II Radiation Protection II Radiographic Film ProcessingRadiological science involves technologists use X-rays to see the inside of the human body. Health

  6. On an integral involving the digamma function

    E-Print Network [OSTI]

    Donal F. Connon

    2012-12-09

    We consider several possible approaches to evaluating an integral involving the digamma function and a related logarithmic series.

  7. Ramsey Numbers Involving Cycles Stanislaw P. Radziszowski

    E-Print Network [OSTI]

    Radziszowski, Stanislaw P.

    Ramsey Numbers Involving Cycles Stanislaw P. Radziszowski Department of Computer Science Rochester and data on Ramsey numbers involving cycles. This survey is based on the author's 2009 revi- sion #12 of the Dynamic Survey DS1, "Small Ramsey Numbers", at the Electronic Journal of Combinatorics. Table of Contents

  8. RESEARCH INVOLVING PRISONERS DEFINITIONS AND EXAMPLES

    E-Print Network [OSTI]

    1 RESEARCH INVOLVING PRISONERS 05/30/2008 DEFINITIONS AND EXAMPLES The DUHS IRB reviews and approves research involving prisoners in compliance with 45 CFR 46 Subpart C and other applicable regulations and laws. The provisions of Subpart C apply whenever the research targets prisoners as subjects

  9. Ethnic differences in parent involvement are moderated by type of involvement scale

    E-Print Network [OSTI]

    Wong, Shuk Wa

    2006-10-30

    This study examines ethnic group differences on different dimensions of parentrated and teacher-rated parent involvement after adjusting for the influence of family socioeconomic factors, and the role of involvement scale ...

  10. Bounds on Some Ramsey Numbers Involving Quadrilateral +

    E-Print Network [OSTI]

    Radziszowski, Stanislaw P.

    Bounds on Some Ramsey Numbers Involving Quadrilateral + Xiaodong Xu Guangxi Academy of Sciences@cs.rit.edu Abstract. For graphs G 1 , G 2 , · · · , Gm , the Ramsey number R(G 1 , G 2 , · · · , Gm ) is defined Ramsey numbers involving quadrilateral C 4 , including R(C 4 , K 9 ) # 32, 19 # R(C 4 , C 4 , K 4 ) # 22

  11. Some Ramsey Problems Involving Triangles -Computational Approach

    E-Print Network [OSTI]

    Radziszowski, Stanislaw P.

    Some Ramsey Problems Involving Triangles - Computational Approach Stanislaw P. Radziszowski at the Ramsey Theory Workshop DIMACS, Rutgers University, May 28, 2009 Definition 1. For graphs G and H, R(G, H graphs, and the multicolor Ramsey numbers R(G1, · · · , Gr). Computational problems for Ramsey numbers

  12. Fire Classifications Fires involving the ordinary

    E-Print Network [OSTI]

    Jia, Songtao

    , plastics, etc. Fires involving combustible or flammable liquids such as gasoline, kerosene, oils, grease to prevent fires. Personnel should neither create nor tolerate conditions that could cause or fuel a fire is protected by various devices such as smoke detectors, sprinkler systems, and manual fire alarm pull stations

  13. Environmental science and ecology involve studies

    E-Print Network [OSTI]

    Christensen, Dan

    Environmental science and ecology involve studies of the biosphere, hydro- sphere, and lithosphere in environmental science is conducted on spatial scales varying from a single algal cell to the Earth as a whole's environmental scientists require investigation by an interdisciplinary team, including members from several

  14. Apolipoprotein gene involved in lipid metabolism

    DOE Patents [OSTI]

    Rubin, Edward (Berkeley, CA); Pennacchio, Len A. (Sebastopol, CA)

    2007-07-03

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  15. Genomic Aspects of Research Involving Polyploid Plants

    SciTech Connect (OSTI)

    Yang, Xiaohan [ORNL; Ye, Chuyu [ORNL; Tschaplinski, Timothy J [ORNL; Wullschleger, Stan D [ORNL; Tuskan, Gerald A [ORNL

    2011-01-01

    Almost all extant plant species have spontaneously doubled their genomes at least once in their evolutionary histories, resulting in polyploidy which provided a rich genomic resource for evolutionary processes. Moreover, superior polyploid clones have been created during the process of crop domestication. Polyploid plants generated by evolutionary processes and/or crop domestication have been the intentional or serendipitous focus of research dealing with the dynamics and consequences of genome evolution. One of the new trends in genomics research is to create synthetic polyploid plants which provide materials for studying the initial genomic changes/responses immediately after polyploid formation. Polyploid plants are also used in functional genomics research to study gene expression in a complex genomic background. In this review, we summarize the recent progress in genomics research involving ancient, young, and synthetic polyploid plants, with a focus on genome size evolution, genomics diversity, genomic rearrangement, genetic and epigenetic changes in duplicated genes, gene discovery, and comparative genomics. Implications on plant sciences including evolution, functional genomics, and plant breeding are presented. It is anticipated that polyploids will be a regular subject of genomics research in the foreseeable future as the rapid advances in DNA sequencing technology create unprecedented opportunities for discovering and monitoring genomic and transcriptomic changes in polyploid plants. The fast accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement.

  16. Implementing an Employee Involvement Program Through an Innovation Competition

    E-Print Network [OSTI]

    Salichs, José G.

    2006-05-19

    . It is on these areas that it must be especially innovative to get advantage over its competitors. Moving in this direction, many organizations have recognized that the clue to innovation is employee involvement; an involvement that translates into assertive corporate...

  17. Solving convex problems involving powers using conic optimization

    E-Print Network [OSTI]

    Glineur, François

    Solving convex problems involving powers using conic optimization and a new self-concordant barrier CFG 07 Heidelberg University CFG 07 Solving convex problems involving powers using conic optimization remarks Future plans CFG 07 Solving convex problems involving powers using conic optimization 2 #12

  18. A Survey of Industrial Involvement in Open Source

    E-Print Network [OSTI]

    A Survey of Industrial Involvement in Open Source yvind Hauge and Andreas Rsdal {oyvind of industrial involvement in open source. The survey is performed in collaboration with participants from). The survey was performed to explore aspects of industrial involvement in open source, as industrial

  19. PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer

    E-Print Network [OSTI]

    PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer from primary tumor tissue- ther lymph node involvement in breast cancer is influenced by gene or miRNA expression of the primary tissue from a group of 96 breast cancer patients balanced for lymph node involvement using Affymetrix

  20. Microsoft Word - Number of Public Involvement Deliverables _2...

    National Nuclear Security Administration (NNSA)

    numerous (+150) video clips and raw video * Maintain the Public Involvement portion of web-based Environmental Management Information System (includes uploading briefings,...

  1. Probative Investigation of the Thermal Stability of Wastes Involved...

    Office of Environmental Management (EM)

    the Thermal Stability of Wastes Involved in February 2014 Waste Isolation Pilot Plant (WIPP) Waste Drum Breach Event Probative Investigation of the Thermal Stability of Wastes...

  2. RESEARCH INVOLVING HUMANS University Policy No.: RH8105

    E-Print Network [OSTI]

    Victoria, University of

    1 RESEARCH INVOLVING HUMANS University Policy No.: RH8105 Classification: Research Approving: Mandated Review: September, 2017 Associated Procedures Procedures for Conducting Human Research PURPOSE 1.00 The purpose of this policy is to: a) set out provisions to ensure Research Involving Human Participants

  3. UNLV DIVISION OF RESEARCH POLICY ON RESEARCH INVOLVING HUMAN SUBJECTS

    E-Print Network [OSTI]

    Walker, Lawrence R.

    UNLV DIVISION OF RESEARCH POLICY ON RESEARCH INVOLVING HUMAN SUBJECTS RESPONsmLE ADMINISTRATOR: VICE PRESIDENT FOR RESEARCH RESPONSmLE OFFICE(S): OFFICE OF RESEARCH INTEGRITY - HUMAN SUBJECTS rules and procedures, when conducting research involving human subjects. ENTITIES AFFECTED BY Tms POLICY

  4. Voluntary Associations and Their Involvement in Collaborative Forest Management

    E-Print Network [OSTI]

    Lu, Jiaying

    2012-02-14

    . This dissertation was aimed at gaining a better understanding of outdoor recreation and environmental voluntary associations and their involvement in collaborative forest management. Five objectives guided this study: (1) assessing the organizational characteristics...

  5. Getting Involved in Manufacturing Day College Educators Edition Webinar

    Broader source: Energy.gov [DOE]

    This webinar will help address questions on why and how community colleges, universities, and technical schools can get involved with MFG DAY. Led by MFG DAY Co-Producers, the webinar will also...

  6. An exploration of meaningful involvement in ropes course programs

    E-Print Network [OSTI]

    Haras, Katryna Stephanie

    2004-09-30

    Ropes course programs provide numerous benefits but what makes programs effective has been unclear. The purpose of the study was to: 1) determine if there was a measurable difference in meaningful involvement between the ...

  7. A fast enriched FEM for Poisson equations involving interfaces

    E-Print Network [OSTI]

    Huynh, Thanh Le Ngoc

    2008-01-01

    We develop a fast enriched finite element method for solving Poisson equations involving complex geometry interfaces by using regular Cartesian grids. The presence of interfaces is accounted for by developing suitable jump ...

  8. Community assessments: Road maps to successful public involvement

    SciTech Connect (OSTI)

    Forrest, C.J. [Equinox Environmental Consultants, Wheaton, IL (United States)

    1995-12-01

    This paper presents a framework for performing comprehensive community assessments to increase the effectiveness of public involvement efforts. The community assessment process involves systematic and critical examination of beliefs, attitudes, opinions and knowledge of the many groups in the community. A good community assessment gathers information on the concerns or issues directly related to an environmental project as well as other important community issues to ensure development of an effective public involvement program. The framework discusses types of people and organizations that should be included in the community assessment interview process. It also delineates steps that persons charged with performing assessments can take to ensure that the views of all potential stakeholders are included--a necessary consideration in communities that are ethnically, racially, or economically diverse. Lastly, the framework discusses types of written materials that can be analyzed for additional insight into communities. For example, it discusses methods for reviewing past issues of the local newspaper to provide both validation of the information gathered during interviews and an understanding of the ways that community members give and receive information and respond to conflict or perceived threats. This framework is designed to show environmental professionals who are responsible for public involvement how to perform an initial community assessment. It provides illustrations of instances in which information vital to a successful public involvement effort has been uncovered through a careful assessment of the community. Both the U.S. EPA and the public have made clear their intentions to require increased public involvement. Many of these efforts will succeed or fail based on how well those charged with the public involvement component of environmental projects identify community issues and design communications programs that successfully reach all stakeholders.

  9. Projecting Fatalities in Crashes Involving Older Drivers, 20002025

    E-Print Network [OSTI]

    ORNL-6963 Projecting Fatalities in Crashes Involving Older Drivers, 20002025 Patricia S. Hu 2000 This research was funded by GM pursuant to an agreement between GM and the U.S. Department #12;#12;GM Project G.6 October 2000iii TABLE OF CONTENTS LIST OF FIGURES

  10. An Honors Thesis in English What does it involve?

    E-Print Network [OSTI]

    Martinez, Tony R.

    1 An Honors Thesis in English What does it involve? Prospectus The prospectus is a document that establishes your intentions for your thesis and makes a strong case for why your project should constitute an Honors thesis. A strong thesis is usually a result of a well developed prospectus. Care and attention

  11. Research Summary Consultation and community involvement in forest planning

    E-Print Network [OSTI]

    Research Summary Consultation and community involvement in forest planning: research in Cranborne of the Forestry Commission's `Long-Term Forest Plan' process. It also builds on various investigations into stakeholder analysis and the use of participatory tools in relation to Forest Design Plans (FDPs). The NFNF

  12. A Protein Export Pathway Involving Escherichia coli Porins

    E-Print Network [OSTI]

    McIntosh, Lawrence P.

    Structure Article A Protein Export Pathway Involving Escherichia coli Porins Gerd Prehna,1,2 Guijin@byron.biochem.ubc.ca (N.C.J.S.) DOI 10.1016/j.str.2012.04.014 SUMMARY Escherichia coli export the protein Yeb common to all E. coli strains has been reported, the mechanism of export has remained unclear. Herein, we

  13. Arm Coordination in Octopus Crawling Involves Unique Motor Control Strategies

    E-Print Network [OSTI]

    Hochner, Binyamin

    Report Arm Coordination in Octopus Crawling Involves Unique Motor Control Strategies Highlights d Octopuses use unique strategies to coordinate their arms in crawling d They can crawl in any direction relative to the facing (body) direction d Arms create pushing thrust by simple shortening

  14. Patterns of Arm Muscle Activation Involved in Octopus Reaching Movements

    E-Print Network [OSTI]

    Hochner, Binyamin

    Patterns of Arm Muscle Activation Involved in Octopus Reaching Movements Yoram Gutfreund,1 Tamar, Stazione Zoologica "A. Dohrn," Naples 80121, Italy The extreme flexibility of the octopus arm allows a basic invariant motor structure: a bend traveling from the base of the arm toward the tip (Gutfreund et

  15. BARNARD COLLEGE Termination of a Research Protocol Involving Human Subjects

    E-Print Network [OSTI]

    BARNARD COLLEGE Termination of a Research Protocol Involving Human Subjects Title: Principal) Study subjects: A total of _____ subjects were enrolled since the last report to the IRB. Since initial study approval on _____________ a total of _____ subjects have been enrolled in this study and ____ have

  16. Research Article Acetylcholinesterase in intestinal cell differentiation involves

    E-Print Network [OSTI]

    Tian, Weidong

    involved in the terminal differentiation of enterocytes. Butyrate, a short-chain fatty acid produced cell line Caco-2 following exposure to sodium butyrate (NaBT), using alkaline phosphatase (ALP, butyrate sodium, G2/M. Introduction The epithelium of the gastrointestinal tract is a complex and dynamic

  17. A1D04: Committee on Public Involvement in Transportation State of the Practice: White Paper on Public Involvement

    E-Print Network [OSTI]

    Handy, Susan L.

    -West Gateway Coordinating Council Public involvement is the process of two-way communication between citizen the passage of the Intermodal Surface Transportation Efficiency Act of 1991 (ISTEA), there has been underserved populations. ISTEA's directive was reinforced by the passage of the Transportation Equity Act

  18. Workplace Charging Challenge Partner: JLA Public Involvement | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematics And Statistics » USAJobs SearchAMERICA'SEnergyof Energy JLA Public Involvement Workplace

  19. Listening, talking triumph in promoting effective public involvement

    SciTech Connect (OSTI)

    Forrest, C.J. [Equinox Environmental Consultants Ltd., Wheaton, IL (United States); Michaud, G.R. [Illinois Environmental Protection Agency`s, Springfield, IL (United States). Office of Community Relations

    1995-07-01

    When added to situations involving formal Superfund cleanups, RCRA permitting and other environmental issues, it is clear that understanding how to handle community concerns is rapidly becoming a necessity for many businesses. The terms public involvement, public participation and community relations all embody the same concept--establishing a dialogue with members of the public who are affected by environmental permitting, a contaminated site or other environmental issues. The goal of the dialogue is to promote public understanding about a project or issue, and ensure that citizens` concerns are considered and thoroughly addressed. Public concerns often are magnified by lack of information, misinformation or false information about an environmental issue. Failing to acknowledge concerns and provide appropriate information can lead to community resistance. In their extreme forms, such communications failures have slowed or blocked the permitting process, and even halted removal of hazardous wastes from residential and nonresidential areas. Community relations requirements under the Comprehensive Environmental Response, Compensation and Liability Act, and public participation requirements under the Resource Conservation and Recovery Act are intended to promote positive dialogue. In both cases, core activities and their timing are set by regulation.

  20. Involvement in Early Childhood Special Education Among Chinese and Non-Chinese American Parents

    E-Print Network [OSTI]

    SooHoo, Tanya

    2012-01-01

    in early childhood special education: Opportunities forInvolvement in Early Childhood Special Education AmongInvolvement in Early Childhood Special Education Among

  1. Product-Process Development Simulation to Support Specialty Contractor Involvement in Early Design

    E-Print Network [OSTI]

    Tommelein, Iris D.

    design of architecture-engineering-construction (AEC) products. Lean construction theory advocates such involvement. The practice of involving suppliers in product development and in manufacturing has proven

  2. File under: H Web name: Human Subjects, Policy on Research Involving [June 29, 2000] Official name: Policy on Research Involving Human Subjects [June 29, 2000] Location

    E-Print Network [OSTI]

    Prodi, Aleksandar

    File under: H Web name: Human Subjects, Policy on Research Involving [June 29, 2000] Official name: Policy on Research Involving Human Subjects [June 29, 2000] Location: https://share.utorcsi.utoronto.ca/sites/gc/Governing%20Council/All%20Policies/H/Human%20Subjects,%20Policy%20on%20Research %20Involving.docx [Official

  3. Boosting cooperation by involving extortion in spatial Prisoner's dilemma

    E-Print Network [OSTI]

    Wu, Zhi-Xi

    2014-01-01

    We study the evolution of cooperation in spatial Prisoner's dilemma games with and without extortion by adopting aspiration-driven strategy updating rule. We focus explicitly on how the strategy updating manner (whether synchronous or asynchronous) and also the introduction of extortion strategy affect the collective outcome of the games. By means of Monte Carlo (MC) simulations as well as dynamical cluster techniques, we find that the involvement of extortioners facilitates the boom of cooperators in the population (and whom can always dominate the population if the temptation to defect is not too large) for both synchronous and asynchronous strategy updating, in stark contrast to the otherwise case, where cooperation is promoted for intermediate aspiration level with synchronous strategy updating, but is remarkably inhibited if the strategy updating is implemented asynchronously. We explain the results by configurational analysis and find that the presence of extortion leads to the checkerboard-like orderin...

  4. Representation of analysis results involving aleatory and epistemic uncertainty.

    SciTech Connect (OSTI)

    Johnson, Jay Dean; Helton, Jon Craig; Oberkampf, William Louis; Sallaberry, Cedric J.

    2008-08-01

    Procedures are described for the representation of results in analyses that involve both aleatory uncertainty and epistemic uncertainty, with aleatory uncertainty deriving from an inherent randomness in the behavior of the system under study and epistemic uncertainty deriving from a lack of knowledge about the appropriate values to use for quantities that are assumed to have fixed but poorly known values in the context of a specific study. Aleatory uncertainty is usually represented with probability and leads to cumulative distribution functions (CDFs) or complementary cumulative distribution functions (CCDFs) for analysis results of interest. Several mathematical structures are available for the representation of epistemic uncertainty, including interval analysis, possibility theory, evidence theory and probability theory. In the presence of epistemic uncertainty, there is not a single CDF or CCDF for a given analysis result. Rather, there is a family of CDFs and a corresponding family of CCDFs that derive from epistemic uncertainty and have an uncertainty structure that derives from the particular uncertainty structure (i.e., interval analysis, possibility theory, evidence theory, probability theory) used to represent epistemic uncertainty. Graphical formats for the representation of epistemic uncertainty in families of CDFs and CCDFs are investigated and presented for the indicated characterizations of epistemic uncertainty.

  5. Personnel involved in nuclear standards development: 1980 directory

    SciTech Connect (OSTI)

    Carr, S.J.

    1980-03-01

    The development of nuclear standards is an active and necessary endeavor that is concerned with the safe, orderly, and economic development of nuclear potential. There are almost 4100 people from the teachnical community who are presently involved either in writing nuclear standards, including codes, or in the management and processing roles necessary for their approval and promulgation. This document identifies the current participation of each individual as member, chairman, cochairman (vice-chairman), or secretary of about 700 standards development committees and groups. The standards committees and groups are identified with the organizations that are responsible for the preparation, review, and maintenance of the standards and that provide support through supervisory committees and headquarters staff. This directory includes four major sections: personnel, employers, committees, and a Key-Word-in-Context (KWIC) Index of committee titles. It can also be used to identify the participation of employers as well as to recognize the contributions of individuals to the often interdisciplinary activity of standards development.

  6. Surface interactions involved in flashover with high density electronegative gases.

    SciTech Connect (OSTI)

    Hodge, Keith Conquest; Warne, Larry Kevin; Jorgenson, Roy Eberhardt; Wallace, Zachariah Red; Lehr, Jane Marie

    2010-01-01

    This report examines the interactions involved with flashover along a surface in high density electronegative gases. The focus is on fast ionization processes rather than the later time ionic drift or thermalization of the discharge. A kinetic simulation of the gas and surface is used to examine electron multiplication and includes gas collision, excitation and ionization, and attachment processes, gas photoionization and surface photoemission processes, as well as surface attachment. These rates are then used in a 1.5D fluid ionization wave (streamer) model to study streamer propagation with and without the surface in air and in SF6. The 1.5D model therefore includes rates for all these processes. To get a better estimate for the behavior of the radius we have studied radial expansion of the streamer in air and in SF6. The focus of the modeling is on voltage and field level changes (with and without a surface) rather than secondary effects, such as, velocities or changes in discharge path. An experiment has been set up to carry out measurements of threshold voltages, streamer velocities, and other discharge characteristics. This setup includes both electrical and photographic diagnostics (streak and framing cameras). We have observed little change in critical field levels (where avalanche multiplication sets in) in the gas alone versus with the surface. Comparisons between model calculations and experimental measurements are in agreement with this. We have examined streamer sustaining fields (field which maintains ionization wave propagation) in the gas and on the surface. Agreement of the gas levels with available literature is good and agreement between experiment and calculation is good also. Model calculations do not indicate much difference between the gas alone versus the surface levels. Experiments have identified differences in velocity between streamers on the surface and in the gas alone (the surface values being larger).

  7. Classroom simulation of public involvement in H.L.W. issues featuring STS concepts

    SciTech Connect (OSTI)

    Bieniawski, Z.T.

    1996-12-01

    This paper reports on a classroom experiment, now in its third year, conducted by the author for students involvement in High-Level Waste disposal. The project involved designing a methodology for HLW management in the United States.

  8. Kindergarten Transition: Does family involvement make a difference in children's early school adjustment?

    E-Print Network [OSTI]

    Kang, Jean

    2010-07-30

    in kindergarten and the specific outcomes of family involvement is still very limited. Using a combination of quantitative and qualitative research methods, this study aims to investigate the impact of family involvement in kindergarten transition on children...

  9. Subbasin Planning Public Involvement Plan 1 Last Revised: 4/4/2004

    E-Print Network [OSTI]

    Subbasin Planning Public Involvement Plan 1 Last Revised: 4/4/2004 Walla Walla, Tucannon, Asotin & Lower Snake River Subbasin Planning Public Involvement Plan Background Public outreach and involvement is key to the success of the subbasin planning process. Without public acceptance and support of the plan

  10. SMALL AND LARGE-SCALE MAGNETIC FIELDS INVOLVED WITH SOLAR FLARES

    E-Print Network [OSTI]

    ABSTRACT SMALL AND LARGE-SCALE MAGNETIC FIELDS INVOLVED WITH SOLAR FLARES by Chang Liu Solar flares of an EUV sigmoid. #12;SMALL AND LARGE-SCALE MAGNETIC FIELDS INVOLVED WITH SOLAR FLARES by Chang Liu RESERVED #12;APPROVAL PAGE SMALL AND LARGE-SCALE MAGNETIC FIELDS INVOLVED WITH SOLAR FLARES Chang Liu Dr

  11. What is the effect of 4-H involvement on levels of empathy, self-esteem, community involvement and positive view of the future on urban youth?

    E-Print Network [OSTI]

    Bonnett, Erika Dawn

    2007-04-25

    -1 WHAT IS THE EFFECT OF 4-H INVOLVEMENT ON LEVELS OF EMPATHY, SELF-ESTEEM, COMMUNITY INVOLVEMENT AND POSITIVE VIEW OF THE FUTURE ON URBAN YOUTH? A Thesis by ERIKA DAWN BONNETT Submitted to the Office of Graduate Studies of Texas A...-ESTEEM, COMMUNITY INVOLVEMENT AND POSITIVE VIEW OF THE FUTURE ON URBAN YOUTH? A Thesis by ERIKA DAWN BONNETT Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER...

  12. 01-12-1998 - Bench Top FIre Involving Use of Alcohol and Burner...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1998 - Bench Top FIre Involving Use of Alcohol and Burner Document Number: NA Effective Date: 011998 File (public): 01-12-1998...

  13. Molecular genetic analysis of activation-tagged transcription factors thought to be involved in photomorphogenesis

    SciTech Connect (OSTI)

    Neff, Michael M.

    2011-06-23

    This is a final report for Department of Energy Grant No. DE-FG02-08ER15927 entitled Molecular Genetic Analysis of Activation-Tagged Transcription Factors Thought to be Involved in Photomorphogenesis. Based on our preliminary photobiological and genetic analysis of the sob1-D mutant, we hypothesized that OBP3 is a transcription factor involved in both phytochrome and cryptochrome-mediated signal transduction. In addition, we hypothesized that OBP3 is involved in auxin signaling and root development. Based on our preliminary photobiological and genetic analysis of the sob2-D mutant, we also hypothesized that a related gene, LEP, is involved in hormone signaling and seedling development.

  14. Customer Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit theCovalent Bonding inCustomer-Comments Sign In About |

  15. Getting Involved

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journalvivo Low-Dose Low LETUseful Links Useful Links:Get

  16. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

    E-Print Network [OSTI]

    Quirk, Gregory J.

    experiments designed to bridge human and rodent models of emotion regulation. Addresses 1 Department of prefrontal involvement of emotion regula- tion using rat and human models, and suggest future experimentsPrefrontal involvement in the regulation of emotion: convergence of rat and human studies Gregory J

  17. Physical mechanisms involved in grooved flat heat pipes: experimental and numerical analyses

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    1 Physical mechanisms involved in grooved flat heat pipes: experimental and numerical analyses.lefevre@insa-lyon.fr) Abstract An experimental database, obtained with flat plate heat pipes (FPHP) with longitudinal grooves to results of numerical models. Physical mechanisms involved in grooved heat pipes are discussed, including

  18. Insensitizing controls for a heat equation with a nonlinear term involving the state and the

    E-Print Network [OSTI]

    Gonzlez Burgos, Manuel

    Insensitizing controls for a heat equation with a nonlinear term involving the state In this paper we present two results on the existence of insensitizing controls for a heat equation in a bounded domain of IRN . We first consider a semilinear heat equation involving gradient terms with homogeneous

  19. Inclusion of Human Subjects in Research Human Subjects Involvement and Characteristics

    E-Print Network [OSTI]

    Firestone, Jeremy

    Inclusion of Human Subjects in Research Human Subjects Involvement and Characteristics: Describe the proposed involvement of human subjects in the work outlined in the Research Design and Methods section. Describe the characteristics of the subject population, including their anticipated number, age range

  20. Abstract--Many large scale system blackouts involve relay misoperations. Traditional relay algorithms and settings need to

    E-Print Network [OSTI]

    1 Abstract--Many large scale system blackouts involve relay misoperations. Traditional relay-wide blackouts involve relay misoperations [1]. Evaluation and improvement of existing relay algorithms

  1. Undergraduate business and management students experiences of being involved in assessment

    E-Print Network [OSTI]

    Tai, Chunming

    2012-11-29

    This study aimed to explore university undergraduates experiences of student involvement in assessment (SIA). Based on Biggs 3P model of student learning, this study focused on students experiences prior to SIA, during ...

  2. The interactive effects of individual learning style, computer software, and teacher involvement on developing typing skill

    E-Print Network [OSTI]

    Goodman, Sarina Renae

    1995-01-01

    This research examines the effects and interactions of an individual's learning style, the type of computer software, and the level of teacher involvement on students learning how to type on a computer keyboard. The research ...

  3. Removing the HUD: The Impact of Non-Diegetic Game Elements and Expertise on Player Involvement

    E-Print Network [OSTI]

    Cairns, Paul

    Removing the HUD: The Impact of Non-Diegetic Game Elements and Expertise on Player Involvement-character can see and interact with; and the latter does not, e.g. classic heads-up displays (HUDs) showing

  4. Examination of offsite radiological emergency protective measures for nuclear reactor accidents involving core melt

    E-Print Network [OSTI]

    Aldrich, David C.

    1979-01-01

    Evacuation, sheltering followed by population relocation, and iodine prophylaxis are evaluated as offsite public protective measures in response to nuclear reactor accidents involving core-melt. Evaluations were conducted ...

  5. The obligation nation : America's involvement in the affairs of the World

    E-Print Network [OSTI]

    Francel, Leif (Leif G.)

    2012-01-01

    Does America have an obligation, whether through foreign aid, military involvement, or by spreading democracy, to change the world? This thesis answers these above questions in intimate detail through the moral framework ...

  6. Cold shock response of Salmonella enterica serovar typhimurium; the involvement of the CspA paralogues

    E-Print Network [OSTI]

    Woodall, Katy Anna

    2011-11-24

    Salmonella enterica sv. typhimurium is a major food-borne pathogen, in part because of its ability to persist and multiply at low temperatures. Adaptation to refrigerated temperatures involves induction of a multigenic ...

  7. School-Based Family Involvement: Patterns and Predictors in the NLTS2

    E-Print Network [OSTI]

    Frew, Leigh Ann

    2012-10-19

    This investigation used data from the National Longitudinal Transition Study 2 (NLTS2) to investigate patterns among student, family, and school characteristics, school outreach programs, and school-based family involvement for families of 5...

  8. A study of parental involvement and school climate: Perspective from the middle school

    E-Print Network [OSTI]

    Dixon, Shantina Rayford

    2009-05-15

    This study examines school level differences on different dimensions of teacherrated parent involvement and school climate while adjusting for age, gender, ethnicity, how certified, and number of years teaching. Two hundred twenty-four elementary...

  9. Offline Memory Reprocessing: Involvement of the Brain's Default Network in Spontaneous Thought Processes

    E-Print Network [OSTI]

    Jiang,Tianzi

    Offline Memory Reprocessing: Involvement of the Brain's Default Network in Spontaneous Thought active during the task-free state. Interestingly, we found that offline reprocessing of previously integration and functional separation among its component regions to execute offline memory reprocessing

  10. The cost of public involvement lessons learned: How we can reinvest in the future

    SciTech Connect (OSTI)

    Baranski, S.C. [Equinox Environmental, Inc., Shushan, NY (United States); McMullin, K.M. [Equinox Environmental, Inc., Ballston Spa, NY (United States)

    1996-12-31

    Throughout the history of environmental remediation and restoration projects, education programs have been viewed as something to develop when the financial climate is good, and something to eliminate when the financial picture declines. Technology and risk are issues that citizens and interested community members have come to be concerned about regardless of the purpose of the project. Many times the public response to an environmental remediation effort is unanticipated. Government and industry representatives often forget that even a {open_quotes}cleanup{close_quotes} effort can cause unrest in a community. Past education and public involvement efforts have been costly, from both a financial perspective and from a public policy and programmatic perspective. Money alone cannot provide education and public involvement opportunities that will enable a project to go forward to completion. Investment in environmental programs and projects for education, public involvement and communication activities has been substantial, from a financial point of view. Investment, from a policy and program success perspective, has not yielded high returns on the investment. One must examine past and current education and public involvement {open_quotes}investments{close_quotes} and where emphasis has been place in development of the programs. In this review, the authors suggest the need to look at the level of investment from the following perspectives: (1) Financial, (2) Educational Opportunity, (3) Public Involvement Opportunity, (4) Policy and Programmatic Success, (5) Evaluation of Cost and Resulting Benefit, and (6) Reinvesting Our Financial Commitments for the Future.

  11. The Community Environmental Monitoring Program: Reducing Public Perception of Risk through Stakeholder Involvement

    SciTech Connect (OSTI)

    William T. Hartwell

    2007-05-21

    The Community Environmental Monitoring Program (CEMP) has promoted stakeholder involvement, awareness, and understanding of radiological surveillance in communities surrounding the Nevada Test Site (NTS) since 1981. It involves stakeholders in the operation, data collection, and dissemination of information obtained from a network of 29 stations across a wide area of Nevada, Utah and California. It is sponsored by the U.S. Department of Energy, National Nuclear Security Administrations Nevada Site Office (NNSA/NSO) and administered by the Desert Research Institute (DRI) of the Nevada System of Higher Education. Integration of a near real-time communications system, a public web site, training workshops for involved stakeholders, and educational programs all help to alleviate public perception of risk of health effects from past activities conducted at the NTS.

  12. Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

    SciTech Connect (OSTI)

    United States. Bonneville Power Administration.

    1994-01-01

    In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

  13. Getting the lead out: Citizen involvement in the Williamsburg Bridge lead paint removal project

    SciTech Connect (OSTI)

    Forker, T.R.

    1997-08-01

    This paper examines the process and results of citizen involvement in developing new environmental control and compliance procedures used by the New York City Department of Transportation (NYC DOT) for lead paint removal on the Williamsburg Bridge and other structures. As a case study of the effects of public involvement in environmental decision-making, the study identifies and discusses the factors that produced failures or successes in satisfying the citizen`s concerns about health risks and the effectiveness of the selected pollution control technology.

  14. Mechanistic Studies on the Radical S-Adenosylmethionine Enzymes Involved in Molybdopterin, Thiamin and Vitamin B12 Biosynthesis

    E-Print Network [OSTI]

    Mehta, Angad P

    2015-02-09

    ) hydroxybenzimidazole synthase, HBI synthase, involved in anaerobic vitamin B12 biosynthesis. MoaA catalyzes the first step in molydopterin biosynthesis where GTP is converted to pterin. This catalysis involves a remarkable rearrangement reaction where the C8...

  15. The EMBO Journal vol. 13 no. 1 1 pp.2592 -2599, 1994 Genetic and molecular analyses of mutations involved in

    E-Print Network [OSTI]

    Higgins, Darren

    involved in Drosophila raf signal transduction Xiangyi Lu, Michael B.Melnick, Jui-Chou Hsu and Norbert

  16. Distributional properties of Euclidean distances in wireless networks involving road systems

    E-Print Network [OSTI]

    Schmidt, Volker

    1 Distributional properties of Euclidean distances in wireless networks involving road systems of large wireless networks. The network geometry is modelled by random geometric graphs, and the locations are closely related with the interference geometry and, consequently, the performance of wireless networks

  17. INVOLVEMENT OF THE FGFR4 Arg388 ALLELE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

    E-Print Network [OSTI]

    Ullrich, Axel

    INVOLVEMENT OF THE FGFR4 Arg388 ALLELE IN HEAD AND NECK SQUAMOUS CELL CARCINOMA Sylvia STREIT 1/Arg polymorphism (388) in head and neck squamous cell carcinomas (HNSCCs) of the oral cavity and the oropharynx and graded into a low, intermediate, or high degree of staining. FGFR4 expression was scored as high in 17

  18. Sensor applications have now touched onto the realms of real-time data processing involving

    E-Print Network [OSTI]

    Najjar, Walid A.

    sensing needs, coupled with an interface integrating up to gigabyte scale energy efficient data storage sound / voice samples. Such applications demand real time storage, filtering, frequency domain analysis involving algorithms as sophisticated as Fast Fourier Transform (FFT), Finite Impulse Response (FIR

  19. The Penrose inequality in general relativity and volume comparison theorems involving scalar curvature (thesis)

    E-Print Network [OSTI]

    Hubert L. Bray

    2009-02-18

    In this thesis we describe how minimal surface techniques can be used to prove the Penrose inequality in general relativity for two classes of 3-manifolds. We also describe how a new volume comparison theorem involving scalar curvature for 3-manifolds follows from these same techniques.

  20. Computationally efficient parabolic equation solutions to seismo-acoustic problems involving

    E-Print Network [OSTI]

    Computationally efficient parabolic equation solutions to seismo-acoustic problems involving thin converged solutions. In this paper, a seismo-acoustic parabolic equation solution is derived utilizing require finer grids to fully sample effects due to elasticity within the layer. As shear wave speeds

  1. [21] FusionBased Strategies to Identify Genes Involved in Degradation of a Specific Substrate

    E-Print Network [OSTI]

    Hampton, Randy

    [21] FusionBased Strategies to Identify Genes Involved in Degradation of a Specific Substrate By RANDOLPH Y. HAMPTON Abstract Fusion proteins have been used in many instances to allow genetic screening Principles of Using Fusion Reporters to Discover Degradation Genes Because protein degradation is highly

  2. Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals the involvement of Mg-chelatase H subunit

    E-Print Network [OSTI]

    Brusslan, Judy

    Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals the involvement of Mg-chelatase H subunit nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins. Arabidopsis GUN (ge. Unlike wild-type plants, gun mutants have nuclear Lhcb1 expression in the absence of chloroplast

  3. Local Involvement in Measuring and Governing Carbon Stocks in China, Vietnam, Indonesia and Laos

    E-Print Network [OSTI]

    26 Local Involvement in Measuring and Governing Carbon Stocks in China, Vietnam, Indonesia and Laos-REDD+ study sites in China, Vietnam, Indonesia and Laos have been trained in establishing vegetation plots in China, Indonesia, Lao PDR and Vietnam from 2011 to 2014. ___________________________ 1 Skindergade 23

  4. Parabolic equation solution of seismo-acoustics problems involving variations in bathymetry and sediment thickness

    E-Print Network [OSTI]

    and sediment thickness Jon M. Collisa and William L. Siegmann Rensselaer Polytechnic Institute110 8th Street within elastic sediment layers. When these methods are implemented together, the parabolic equation method can be applied to problems involving variations in bathymetry and the thickness of sediment layers

  5. Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene Receptor

    E-Print Network [OSTI]

    Klee, Harry J.

    Response to Xanthomonas campestris pv. vesicatoria in Tomato Involves Regulation of Ethylene ethylene's role in plant response to virulent and avirulent strains of Xanthomonas campestris pv overexpressing a wild-type NR cDNA were infected with virulent X. campestris pv. vesicatoria. Like the Nr mutant

  6. Emergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    -492-6025. For Non-Emergency Fire and Natural Gas Questions call the CU Fire Marshall @ 303-492-4042. AdditionalEmergency Action Plan For incidents involving hazardous materials, fires, explosions, or natural gas leaks, the following actions should be taken: 1) Life Safety First 2) Evacuate Immediate Area 3

  7. Marketing involves the design, pricing, promotion and distribution of goods and services for consumers.

    E-Print Network [OSTI]

    5/2013 MARKETING Marketing involves the design, pricing, promotion and distribution of goods marketing's critical role in analyzing consumer needs and the importance of securing information designed and services for consumers. Marketing encompasses consumer behavior, retail business site selection, store

  8. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  9. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    SciTech Connect (OSTI)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county`s future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  10. Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by FeO

    E-Print Network [OSTI]

    Metz, Ricardo B.

    Electronic spectroscopy of intermediates involved in the conversion of methane to methanol by Fe.1063/1.1448489 I. INTRODUCTION The direct oxidation of methane to an easily transport- able liquid such as methanol process and as the simplest model for alkane oxidation.1,2 Although no direct, efficient methanemethanol

  11. Study: Among Street-Involved Youth, Women Twice as Likely to be Infected with Hepatitis C

    E-Print Network [OSTI]

    Kavanagh, Karen L.

    Study: Among Street-Involved Youth, Women Twice as Likely to be Infected with Hepatitis C Vancouver the hepatitis C virus (HCV), according to a new study by the BC Centre for Excellence in HIV/AIDS (BC surveillance data, on a national scale, men have higher rates of hepatitis C diagnosis than women (36.8 per 100

  12. Planning for multiple mobile robots in dynamic environ ments involves determining the optimal path each robot

    E-Print Network [OSTI]

    Stentz, Tony

    Abstract Planning for multiple mobile robots in dynamic environ ments involves determining the optimal path each robot should follow to accomplish the goals of the mission, given the current knowledge reassign robots to goals in order to continually minimize the time to complete the mission. In this paper

  13. On the Cover: One route to harvesting the energy of the sun involves learning to mimic

    E-Print Network [OSTI]

    Wu, Zhigang

    #12;On the Cover: One route to harvesting the energy of the sun involves learning to mimic natural the chlorophylls, which play a central role in capturing light and using its energy for photosynthesis in green, and atmospheric carbon dioxide. #12;BASIC RESEARCH NEEDS FOR SOLAR ENERGY UTILIZATION Report on the Basic Energy

  14. Differing Professional Opinions Manual for Technical Issues Involving Environment, Safety, and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-11-16

    This Manual establishes a differing professional opinion (DPO) policy to a Department of Energy (DOE) Differing Professional Opinion (DPO) Process to encourage and facilitate dialogue and resolution on DPOs from employees for technical issues involving environment, safety, and health. Does not cancel other directives. Canceled by DOE O 442.2.

  15. Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons

    E-Print Network [OSTI]

    Quantitative traits loci (QTL) involved in body colour, wing morphometry, cuticular hydrocarbons for wing morphometry, 12 for cuticular hydrocarbons and five for venom components. We detected 50 QTL / cuticular hydrocarbons / venom 1. INTRODUCTION The first genetic map built from RAPD markers (Hunt and Page

  16. Statistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter

    E-Print Network [OSTI]

    Washington at Seattle, University of

    Statistical Issues in the Study of Air Pollution Involving Airborne Particulate Matter Lawrence H which provides the Center's primary funding. #12;1 STATISTICAL ISSUES IN THE STUDY OF AIR POLLUTION.S. cities. This and other scientific and policy information formed the basis on which the U.S. Environmental

  17. A ash-drag effect in random motion reveals involvement of preattentive motion processing

    E-Print Network [OSTI]

    Whitney, David

    A ash-drag effect in random motion reveals involvement of preattentive motion processing Department-ku, Tokyo, JapanIkuya Murakami The ash-drag (FDE) effect refers to the phenomenon in which the position of a stationary ashed object in one location appears shifted in the direction of nearby motion. Over the past

  18. Real and padic expansions involving symmetric patterns Boris ADAMCZEWSKI & Yann BUGEAUD

    E-Print Network [OSTI]

    Bugeaud, Yann

    , and by questions related to the expected normality of irrational algebraic numbers. We introduce a class symmetric patterns. Then, we prove several transcendence statements involving both real and p­adic numbers) expansion of irrational algebraic real (resp. p­adic) numbers. Moreover, it is expected that these numbers

  19. 3280 J. Am. Chem. Soc. 1982, 104, 3280-3287 Energetics and Mechanisms for Reactions Involving

    E-Print Network [OSTI]

    Goddard III, William A.

    is thought4 to involve several of species I-IX. In addition, thermochemical studies of I-IX provide limited thermochemical data are available. Several ab initio calculations on N2H20isomers have previously ;>N-N- 37.6 35.4 3.0 IX Table 11. Relative Enthalpies (at 298 K) Useful in AnalyzingReaction 57 NH

  20. The involvement of recurrent connections in area CA3 in establishing the properties of place elds

    E-Print Network [OSTI]

    Dayan, Peter

    The involvement of recurrent connections in area CA3 in establishing the properties of place #12 model of CA3 place #12;elds 51 text pages, 12 #12;gures, 1 table 206 words in abstract, 474- tions. We describe an attractor network model of area CA3 in which local, recurrent, excitatory

  1. Introduction Animals must feed to survive, but foraging often involves a

    E-Print Network [OSTI]

    Sokolowski, Marla

    from predators, parasites, exhaustion or toxins, for example. Many risk-mitigation adaptations, which., 2006). Within a species, individuals may exhibit polymorphic and/or plastic responses to fluctuating food availability. Naturally varying genes involved in plastic responses to changes in food

  2. The Case for APICS Involvement with Auto-ID Technology Edmund W. Schuster

    E-Print Network [OSTI]

    Brock, David

    members. The establishment of industry standards for the Universal Product Code (UPC) is a major reason so many organizations belong to the UCC. Though APICS is not in a position to develop industry standards of the reason traces to a historical lack of involvement from the food industry in society matters

  3. RNS and Pure Spinors Equivalence for Type I Tree Level Amplitudes Involving up to Four Fermions

    E-Print Network [OSTI]

    G. Alencar; M. O. Tahim; R. R. Landim; R. N. Costa Filho

    2011-11-25

    In this paper we give a proof of the equivalence between the RNS and Pure Spinor formalism for Type I tree level amplitudes involving up to four fermions. This result have been obtained previously for amplitudes involving only closed or open amplitudes and here we extend it to include Type I amplitudes. For this we first prove the cyclic symmetry of Type I superstring in a way that it is also valid for the Pure Spinor formalism. The technique used is applied to simplify the calculation of the tree level three point amplitude previously computed. As a byproduct, we are able to calculate the gauge anomaly amplitude of type I Superstrings in this formalism.

  4. Multicolor Ramsey Numbers Involving K3 + e and K4 -e

    E-Print Network [OSTI]

    Radziszowski, Stanislaw P.

    On Some Multicolor Ramsey Numbers Involving K3 + e and K4 - e Daniel S. Shetler Department: The Ramsey number R(G1, G2, G3) is the smallest positive in- teger n such that for all 3-colorings color. We study the bounds on various 3-color Ramsey numbers R(G1, G2, G3), where Gi {K3, K3 + e, K4

  5. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF

    SciTech Connect (OSTI)

    Li, Feifei; Jiang, Yinan [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China); Zheng, Qiping [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States)] [Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612 (United States); Yang, Xiaoming [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China)] [Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850 (China); Wang, Siying, E-mail: sywang@ahmu.edu.cn [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)] [Department of Pathophysiology, Anhui Medical University, Hefei 230032 (China)

    2011-01-07

    Research highlights: {yields} TEC is rapidly tyrosine-phosphorylated and activated by HGF-stimulation in vivo or after partial hepatectomy in mice. {yields} TEC enhances the activity of Elk and serum response element (SRE) in HGF signaling pathway in hepatocyte. {yields} TEC promotes hepatocyte proliferation through the Erk-MAPK pathway. -- Abstract: Background/aims: TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore which signaling pathway TEC is involved in, and how TEC is activated in hepatocyte after hepatectomy and hepatocyte growth factor (HGF) stimulation. Methods: We performed immunoprecipitation (IP) and immunoblotting (IB) to examine TEC tyrosine phosphorylation after partial hepatectomy in mice and HGF stimulation in WB F-344 hepatic cells. The TEC kinase activity was determined by in vitro kinase assay. Reporter gene assay, antisense oligonucleotide and TEC dominant negative mutant (TEC{sup KM}) were used to examine the possible signaling pathways in which TEC is involved. The cell proliferation rate was evaluated by {sup 3}H-TdR incorporation. Results: TEC phosphorylation and kinase activity were increased in 1 h after hepatectomy or HGF treatment. TEC enhanced the activity of Elk and serum response element (SRE). Inhibition of MEK1 suppressed TEC phosphorylation. Blocking TEC activity dramatically decreased the activation of Erk. Reduced TEC kinase activity also suppressed the proliferation of WB F-344 cells. These results suggest TEC is involved in the Ras-MAPK pathway and acts between MEK1 and Erk. Conclusions: TEC promotes hepatocyte proliferation and regeneration and is involved in HGF-induced Erk signaling pathway.

  6. Deuteron stripping and pickup involving halo nuclei 11Be and 15C

    E-Print Network [OSTI]

    A. Deltuva

    2009-04-22

    Three-body calculations of (d,p) and (p,d) reactions involving one-neutron halo nuclei 11Be and 15C are performed using the framework of Faddeev-type scattering equations. Important effects of the optical potential nonlocality are found improving the description of the experimental data. The obtained values for the neutron spectroscopic factor are consistent with estimations from other approaches.

  7. Spatial arrangement of trail markers and visitor involvement on a self-guided interpretive trail

    E-Print Network [OSTI]

    Marcy, Julie Benedict

    1982-01-01

    be presented by asking "what constitutes an effective SGT in terms of visitor involvement with t'ne trail, leaflet suggestions, and the spacing of stakes or markers on the trail?" An effecrive program or technique is one which achieves its desired... concluded with open-ended questions on suggested improvements for the trail and leaflet. Sontag (27) states rhat there are three main ccmponents of t. rail evaluation: personal objeccive evaluation, observing visitor reaction, and questionnaires...

  8. Temperature of aircraft cargo flame exposure during accidents involving fuel spills

    SciTech Connect (OSTI)

    Mansfield, J.A.

    1993-01-01

    This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

  9. 35.1 Introduction Flows.involving.phase.change.are.ubiquitous.in.geophysical.and.

    E-Print Network [OSTI]

    Huppert, Herbert

    467 35.1 Introduction Flows.involving.phase.change.are.ubiquitous.in.geophysical.and. industrial.and.atmosphere.but.also.some.that.occur.in.water- saturated.soils,.in.magmatic.systems,.and.in.industrial.processes. 35.2 Principles Changes.of.phase,.from.and.associated.buoyancy.forces..The.importance.of.phase. change.to.a.given.flow.can.be.assessed.by.estimating.certain.key. dimensionless.parameters. 35

  10. Involvement of HIF-2?-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Zhao, Yue; Xu, Wenchao; Luo, Fei; Wang, Bairu; Li, Yuan; Pang, Ying; Liu, Qizhan, E-mail: drqzliu@hotmail.com

    2013-10-15

    Arsenic is a well established human carcinogen that causes diseases of the lung. Some studies have suggested a link between inflammation and lung cancer; however, it is unknown if arsenite-induced inflammation causally contributes to arsenite-caused malignant transformation of cells. In this study, we investigated the molecular mechanisms underlying inflammation during neoplastic transformation induced in human bronchial epithelial (HBE) cells by chronic exposure to arsenite. The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1? (IL-1?). The data also indicated that HIF-2? was involved in arsenite-induced inflammation. Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells. Thus, these experiments show that HIF-2? mediates arsenite-induced inflammation and that such inflammation is involved in arsenite-induced malignant transformation of HBE cells. The results provide a link between the inflammatory response and the acquisition of a malignant transformed phenotype by cells chronically exposed to arsenite and thus establish a previously unknown mechanism for arsenite-induced carcinogenesis. - Highlights: Arsenite induces inflammation. Arsenite-induced the increases of IL-6 and IL-8 via HIF-2?. Inflammation is involved in arsenite-induced carcinogenesis.

  11. Quality control procedures for dynamic treatment delivery techniques involving couch motion

    SciTech Connect (OSTI)

    Yu, Victoria Y.; Fahimian, Benjamin P.; Xing, Lei; Hristov, Dimitre H.

    2014-08-15

    In this study, the authors introduce and demonstrate quality control procedures for evaluating the geometric and dosimetric fidelity of dynamic treatment delivery techniques involving treatment couch motion synchronous with gantry and multileaf collimator (MLC). Tests were designed to evaluate positional accuracy, velocity constancy and accuracy for dynamic couch motion under a realistic weight load. A test evaluating the geometric accuracy of the system in delivering treatments over complex dynamic trajectories was also devised. Custom XML scripts that control the Varian TrueBeam STx (Serial #3) axes in Developer Mode were written to implement the delivery sequences for the tests. Delivered dose patterns were captured with radiographic film or the electronic portal imaging device. The couch translational accuracy in dynamic treatment mode was 0.01 cm. Rotational accuracy was within 0.3, with 0.04 cm displacement of the rotational axis. Dose intensity profiles capturing the velocity constancy and accuracy for translations and rotation exhibited standard deviation and maximum deviations below 3%. For complex delivery involving MLC and couch motions, the overall translational accuracy for reproducing programmed patterns was within 0.06 cm. The authors conclude that in Developer Mode, TrueBeam is capable of delivering dynamic treatment delivery techniques involving couch motion with good geometric and dosimetric fidelity.

  12. Investigation of Skin Tribology and Its Effects on Coefficient of Friction and Other Tactile Attributes Involving Polymer Applications

    E-Print Network [OSTI]

    Darden, Matthew Aguirre

    2012-02-14

    OF SKIN TRIBOLOGY AND ITS EFFECTS ON COEFFICIENT OF FRICTION AND OTHER TACTILE ATTRIBUTES INVOLVING POLYMER APPLICATIONS A Thesis by MATTHEW AGUIRRE DARDEN Submitted to the Office of Graduate Studies of Texas A&M University in partial... Tactile Attributes Involving Polymer Applications Copyright 2010 Matthew Aguirre Darden INVESTIGATION OF SKIN TRIBOLOGY AND ITS EFFECTS ON COEFFICIENT OF FRICTION AND OTHER TACTILE ATTRIBUTES INVOLVING POLYMER APPLICATIONS A Thesis...

  13. THE RELATIONSHIP BETWEEN HIGH INVOLVEMENT WORK SYSTEMS, SUPERVISORY SUPPORT, AND ORGANIZATIONAL EFFECTIVENESS: THE ROLE OF EMPLOYEE EXPERIENCES AT WORK

    E-Print Network [OSTI]

    Wadhwa, Preeti

    2012-08-31

    This study adopts a multilevel, multiple stakeholder perspective to examine the impact of high involvement work systems (HIWS) and supervisory support on organizational effectiveness. Organizational effectiveness is measured ...

  14. Involvement of purinergic system in inflammation and toxicity induced by copper in zebrafish larvae

    SciTech Connect (OSTI)

    Leite, Carlos Eduardo, E-mail: carlos.leite@pucrs.br [Instituto de Toxicologia e Farmacologia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Programa de Ps-Graduao em Medicina: Cincias Mdicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, CEP 90035-003 (Brazil); Maboni, Lucas de Oliveira [Instituto de Toxicologia e Farmacologia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Biocincias, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Cruz, Fernanda Fernandes [Instituto de Toxicologia e Farmacologia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Faculdade de Farmcia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, CEP 90619-900 (Brazil); Rosemberg, Denis Broock [Programa de Ps-graduao em Cincias Ambientais, Universidade Comunitria da Regio de Chapec, Chapec, CEP 89809-000 (Brazil); and others

    2013-11-01

    The use of zebrafish (Danio rerio) is increasing as an intermediate preclinical model, to prioritize drug candidates for mammalian testing. As the immune system of the zebrafish is quite similar to that of mammals, models of inflammation are being developed for the screening of new drugs. The characterization of these models is crucial for studies that seek for mechanisms of action and specific pharmacological targets. It is well known that copper is a metal that induces damage and cell migration to hair cells of lateral line of zebrafish. Extracellular nucleotides/nucleosides, as ATP and adenosine (ADO), act as endogenous signaling molecules during tissue damage by exerting effects on inflammatory and immune responses. The present study aimed to characterize the inflammatory status, and to investigate the involvement of the purinergic system in copper-induced inflammation in zebrafish larvae. Fishes of 7 days post-fertilization were exposed to 10 ?M of copper for a period of 24 h. The grade of oxidative stress, inflammatory status, copper uptake, the activity and the gene expression of the enzymes responsible for controlling the levels of nucleotides and adenosine were evaluated. Due to the copper accumulation in zebrafish larvae tissues, the damage and oxidative stress were exacerbated over time, resulting in an inflammatory process involving IL-1?, TNF-?, COX-2 and PGE{sub 2}. Within the purinergic system, the mechanisms that control the ADO levels were the most involved, mainly the reactions performed by the isoenzyme ADA 2. In conclusion, our data shed new lights on the mechanisms related to copper-induced inflammation in zebrafish larvae. - Graphical abstract: This scheme provides a chronological proposition for the biochemical events induced by copper in zebrafish larvae. The dashed line shows the absorption of copper over the exposure time. After 1 h of exposure to copper, the release of PGE{sub 2} occurs, followed by an increase of MPO (as a consequence of neutrophil migration), increased expression of genes involved in inflammatory events (IL-1? and TNF-?) and, reduction of the anti-inflammatory cytokine IL-10 at 4 h. At 24 h, the copper concentration is found highly increased, what is coincident with oxidative stress. Regarding the purinergic system, it is possible to observe an inhibition of ecto-5?-NT and ADA, with the consequent increase of AMP and ADA, respectively, at 24 h. The expression of enzyme-related genes shows a decrease in the expression of ecto-5?-NT and variable expressions of ADA subfamily enzymes. - Highlights: Copper led to increased oxidative stress, and decreased the antioxidants' defenses. Copper induced time-related changes of IL-1?, TNF-?, IL-10 and PGE{sub 2} levels. ADA activity controls the levels of adenosine in copper-induced inflammation. ADA 2 is the main ADA subfamily involved. The purinergic system seems to be involved in the resolution of inflammation.

  15. Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation. Final report

    SciTech Connect (OSTI)

    Baulch, Janet

    2013-09-11

    This is a 'glue grant' that was part of a DOE Low Dose project entitled 'Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation'. This collaborative program has involved Drs. David L. Springer from Pacific Northwest National Laboratory (PNNL), John H. Miller from Washington State University, Tri-cities (WSU) and William F. Morgan then from the University of Maryland, Baltimore (UMB). In July 2008, Dr. Morgan moved to PNNL and Dr. Janet E. Baulch became PI for this project at University of Maryland. In November of 2008, a one year extension with no new funds was requested to complete the proteomic analyses. The project stemmed from studies in the Morgan laboratory demonstrating that genomically unstable cells secret a soluble factor or factors into the culture medium, that cause cytogenetic aberrations and apoptosis in normal parental GM10115 cells. The purpose of this project was to identify the death inducing effect (DIE) factor or factors, estimate their relative abundance, identify the cell signaling pathways involved and finally recapitulate DIE in normal cells by exogenous manipulation of putative DIE factors in culture medium. As reported in detail in the previous progress report, analysis of culture medium from the parental cell line, and stable and unstable clones demonstrated inconsistent proteomic profiles as relate to candidate DIE factors. While the proposed proteomic analyses did not provide information that would allow DIE factors to be identified, the analyses provided another important set of observations. Proteomic analysis suggested that proteins associated with the cellular response to oxidative stress and mitochondrial function were elevated in the medium from unstable clones in a manner consistent with mitochondrial dysfunction. These findings correlate with previous studies of these clones that demonstrated functional differences between the mitochondria of stable and unstable clones. These mitochondrial abnormalities in the unstable clones contributes to oxidative stress.

  16. LOFAR-UK White Paper: A Science case for UK involvement in LOFAR

    E-Print Network [OSTI]

    P. N. Best; the LOFAR-UK Consortium

    2008-02-08

    LOFAR, the Low-Frequency Array, is a next-generation software-driven radio telescope operating between 30 and 240MHz, currently under construction by ASTRON in the Netherlands. This low frequency radio band is one of the few largely unexplored regions of the electromagnetic spectrum. The sensitivity and angular resolution offered by LOFAR will be two to three orders of magnitude better than existing telescopes, and as such it will open up this new window on the Universe. LOFAR will impact on a broad range of astrophysics, from cosmology to solar system studies. There is growing European involvement in LOFAR, driven by the need to add stations far from the main core in order to improve angular resolution. LOFAR-UK is a project aimed at cementing UK participation in LOFAR via the operation of four stations within the UK. LOFAR-UK ground stations will allow LOFAR observations to reach sub-arcsecond scales at the highest frequencies, and as a result will also improve the (confusion-limited) sensitivity limit of the telescope for deep surveys. LOFAR-UK will achieve involvement for UK astronomers in a world-leading science facility operating in the immediate future. It will allow the UK to build up important scientific and technical expertise in `next generation' radio astronomy in preparation for the Square Kilometre Array (SKA), and will play an important role in broadening the UK community that has an interest in radio astronomy. This White Paper outlines the strategic importance to the UK astronomy community of gaining involvement in the LOFAR project, the scientific interests of UK researchers in using the telescope, and the technical challenges that will need to be overcome [abridged].

  17. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    Not Available

    1999-01-01

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  18. Fatal accidents involving roof falls in coal mining, 1996--1998

    SciTech Connect (OSTI)

    NONE

    1999-11-01

    This publication presents information on fatalities involving roof and rib falls that occurred in coal mining operations from January 1996 through December 1998. It includes statistics for the fatalities, as well as abstracts, best practices and illustrations. Conclusion statements have been substituted for best practices where no Title 30 Code of Regulations violations were cited during the accident investigation. From January 1996 through December 1998, 36 miners died at coal operations from accidents classified as roof falls. The information in the report is based on statistics taken from the 1996 through 1998 MSHA Fatal Illustration Programs: Roof Fall Fatalities by District.

  19. Use of Science in Gulf of Mexico Decision Making Involving Climate Change

    E-Print Network [OSTI]

    Vedlitz, Arnold; Alston, Letitia T.; Laska, Shirley B.; Gramling, Robert B.; Harwell, Mark A.; Worthen, Helen D.

    2007-01-01

    Decision Making Involving Climate Change EPA COOPERATIVE AGREEMENT: R?83023601?0 September 2002 ? December 2007 Dr. ArnolD VeDlitz, Director & BoB Bullock chAir in GoVernment AnD PuBlic Policy institute for science, technoloGy AnD PuBlic Policy... Policy ? The Bush School ? Texas A&M University i Acknowledgements Research Support This material is based upon research supported by the U.S. Environmental Protection Agency's National Center for Environmental Assessment/Global Change Research...

  20. Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide

    SciTech Connect (OSTI)

    Kurokawa, Yuko; Sekiguchi, Fumiko; Kubo, Satoko; Yamasaki, Yoshiko; Matsuda, Sachi; Okamoto, Yukari; Sekimoto, Teruki; Fukatsu, Anna; Nishikawa, Hiroyuki [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Kume, Toshiaki [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Fukushima, Nobuyuki [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Molecular Neurobiology, Department of Life Sciences, Kinki University School of Science and Engineering, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan); Akaike, Akinori [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan)] [Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501 (Japan); Kawabata, Atsufumi, E-mail: kawabata@phar.kindai.ac.jp [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka 577-8502 (Japan)

    2011-11-04

    Highlights: Black-Right-Pointing-Pointer Hydrogen sulfide causes NMDA receptor-independent neurotoxicity in mouse fetal cortical neurons. Black-Right-Pointing-Pointer Activation of ERK mediates the toxicity of hydrogen sulfide. Black-Right-Pointing-Pointer Apoptotic mechanisms are involved in the hydrogen-induced cell death. -- Abstract: Hydrogen sulfide (H{sub 2}S), a gasotransmitter, exerts both neurotoxicity and neuroprotection, and targets multiple molecules including NMDA receptors, T-type calcium channels and NO synthase (NOS) that might affect neuronal viability. Here, we determined and characterized effects of NaHS, an H{sub 2}S donor, on cell viability in the primary cultures of mouse fetal cortical neurons. NaHS caused neuronal death, as assessed by LDH release and trypan blue staining, but did not significantly reduce the glutamate toxicity. The neurotoxicity of NaHS was resistant to inhibitors of NMDA receptors, T-type calcium channels and NOS, and was blocked by inhibitors of MEK, but not JNK, p38 MAP kinase, PKC and Src. NaHS caused prompt phosphorylation of ERK and upregulation of Bad, followed by translocation of Bax to mitochondria and release of mitochondrial cytochrome c, leading to the nuclear condensation/fragmentation. These effects of NaHS were suppressed by the MEK inhibitor. Our data suggest that the NMDA receptor-independent neurotoxicity of H{sub 2}S involves activation of the MEK/ERK pathway and some apoptotic mechanisms.

  1. Polo-like Kinase I is involved in Invasion through Extracellular Matrix

    SciTech Connect (OSTI)

    Bissell, Mina J; Rizki, Aylin; Mott, Joni D.; Bissell, Mina J

    2008-04-02

    Polo-like kinase 1, PLK1, has important functions in maintaining genome stability and is involved in regulation of mitosis. PLK1 is up regulated in many invasive carcinomas. We asked whether it may also play a role in acquisition of invasiveness, a crucial step in transition to malignancy. In a model of metaplastic basal-like breast carcinoma progression, we found that PLK1 expression is necessary but not sufficient to induce invasiveness through laminin-rich extracellular matrix. PLK1 mediates invasion via Vimentin and {beta}1 integrin, both of which are necessary. We observed that PLK1 phosphorylates Vimentin on serine 82, which in turn regulates cell surface levels of {beta}1 integrin. We found PLK1 to be also highly expressed in pre-invasive in situ carcinomas of the breast. These results support a role for the involvement of PLK1 in the invasion process and point to this pathway as a potential therapeutic target for pre-invasive and invasive breast carcinoma treatment.

  2. Finding candidate genes under positive selection in Non-model species: examples of genes involved in host

    E-Print Network [OSTI]

    of positive selection were putatively involved in nutrient uptake from the host, secondary metabolite, UMR 7205, CNRS-MNHN, Origine, Structure et Evolution de la Biodiversite, Departement Syste and to develop vaccines or drugs. To elucidate the functions involved in host specialization, here we aimed

  3. Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through Deuterium Exchange

    E-Print Network [OSTI]

    Crofts, Antony R.

    Hydrogen Bonds Involved in Binding the Qi-site Semiquinone in the bc1 Complex, Identified through them. The strength of interactions indicates that the protons are involved in hydrogen bonds with SQ. The hyperfine cou- plings differ from values typical for in-plane hydrogen bonds previously observed in model

  4. To examine how the dynamics of recall processes are affected by the control processes involved with search termination, to study

    E-Print Network [OSTI]

    Dougherty, Michael

    involved with search termination, to study the implications of these control processes for the development at understanding the metacognitive control processes involved with the decision to terminate memory search. Specifically, research examines the impact of search termination decisions on the natural retrieval dynamics

  5. Examining the consistency relations describing the three-point functions involving tensors

    SciTech Connect (OSTI)

    Sreenath, V.; Sriramkumar, L., E-mail: sreenath@physics.iitm.ac.in, E-mail: sriram@physics.iitm.ac.in [Department of Physics, Indian Institute of Technology Madras, Chennai 600036 (India)

    2014-10-01

    It is well known that the non-Gaussianity parameter f{sub NL} characterizing the scalar bi-spectrum can be expressed in terms of the scalar spectral index in the squeezed limit, a property that is referred to as the consistency relation. In contrast to the scalar bi-spectrum, the three-point cross-correlations involving scalars and tensors and the tensor bi-spectrum have not received adequate attention, which can be largely attributed to the fact that the tensors had remained undetected at the level of the power spectrum until very recently. The detection of the imprints of the primordial tensor perturbations by BICEP2 and its indication of a rather high tensor-to-scalar ratio, if confirmed, can open up a new window for understanding the tensor perturbations, not only at the level of the power spectrum, but also in the realm of non-Gaussianities. In this work, we consider the consistency relations associated with the three-point cross-correlations involving scalars and tensors as well as the tensor bi-spectrum in inflationary models driven by a single, canonical, scalar field. Characterizing the cross-correlations in terms of the dimensionless non-Gaussianity parameters C{sub NL}{sup R} and C{sub NL}{sup ?} that we had introduced earlier, we express the consistency relations governing the cross-correlations as relations between these non-Gaussianity parameters and the scalar or tensor spectral indices, in a fashion similar to that of the purely scalar case. We also discuss the corresponding relation for the non-Gaussianity parameter h{sub NL} used to describe the tensor bi-spectrum. We analytically establish these consistency relations explicitly in the following two situations: a simple example involving a specific case of power law inflation and a non-trivial scenario in the so-called Starobinsky model that is governed by a linear potential with a sharp change in its slope. We also numerically verify the consistency relations in three types of inflationary models that permit deviations from slow roll and lead to scalar power spectra with features which typically result in an improved fit to the data than the more conventional, nearly scale invariant, spectra. We close with a summary of the results we have obtained.

  6. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    SciTech Connect (OSTI)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 ?g/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ? Endothelial HO1 is upregulated by ozonated plasma ? This activation is induced by NRF2 and it is ERK independent. ? 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ? Ozonated plasma induced a hormetic effect ? Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  7. Pore scale modeling of reactive transport involved in geologic CO2 sequestration

    SciTech Connect (OSTI)

    Kang, Qinjin [Los Alamos National Laboratory; Lichtner, Peter C [Los Alamos National Laboratory; Viswanathan, Hari S [Los Alamos National Laboratory; Abdel-fattah, Amr I [Los Alamos National Laboratory

    2009-01-01

    We apply a multi-component reactive transport lattice Boltzmann model developed in previolls studies to modeling the injection of a C02 saturated brine into various porous media structures at temperature T=25 and 80 C. The porous media are originally consisted of calcite. A chemical system consisting of Na+, Ca2+, Mg2+, H+, CO2(aq), and CI-is considered. The fluid flow, advection and diHusion of aqueous species, homogeneous reactions occurring in the bulk fluid, as weB as the dissolution of calcite and precipitation of dolomite are simulated at the pore scale. The effects of porous media structure on reactive transport are investigated. The results are compared with continuum scale modeling and the agreement and discrepancy are discussed. This work may shed some light on the fundamental physics occurring at the pore scale for reactive transport involved in geologic C02 sequestration.

  8. Astrophysical S-factors for fusion reactions involving C, O, Ne and Mg isotopes

    E-Print Network [OSTI]

    M. Beard; A. V. Afanasjev; L. C. Chamon; L. R. Gasques; M. Wiescher; D. G. Yakovlev

    2010-02-03

    Using the Sao Paulo potential and the barrier penetration formalism we have calculated the astrophysical factor S(E) for 946 fusion reactions involving stable and neutron-rich isotopes of C, O, Ne, and Mg for center-of-mass energies E varying from 2 MeV to 18-30 MeV (covering the range below and above the Coulomb barrier). We have parameterized the energy dependence S(E) by an accurate universal 9-parameter analytic expression and present tables of fit parameters for all the reactions. We also discuss the reduced 3-parameter version of our fit which is highly accurate at energies below the Coulomb barrier, and outline the procedure for calculating the reaction rates. The results can be easily converted to thermonuclear or pycnonuclear reaction rates to simulate various nuclear burning phenomena, in particular, stellar burning at high temperatures and nucleosynthesis in high density environments.

  9. The Orosomucoid 1 protein is involved in the vitamin D mediated macrophage de-activation process

    SciTech Connect (OSTI)

    Gemelli, Claudia, E-mail: claudia.gemelli@unimore.it [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy); Center for Regenerative Medicine, University of Modena and Reggio Emilia, Via Gottardi 100, 41125 Modena (Italy); Martello, Andrea; Montanari, Monica; Zanocco Marani, Tommaso; Salsi, Valentina; Zappavigna, Vincenzo; Parenti, Sandra; Vignudelli, Tatiana; Selmi, Tommaso; Ferrari, Sergio; Grande, Alexis [Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena (Italy)

    2013-12-10

    Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties. The present study was designed to identify a possible correlation between ORM1 and Vitamin D3 (1,25(OH)2D3), a hormone exerting a widespread effect on cell proliferation, differentiation and regulation of the immune system. In particular, the data described here indicated that ORM1 is a 1,25(OH)2D3 primary response gene, characterized by the presence of a VDRE element inside the 1 kb sequence of its proximal promoter region. This finding was demonstrated with gene expression studies, Chromatin Immunoprecipitation and luciferase transactivation experiments and confirmed by VDR full length and dominant negative over-expression. In addition, several experiments carried out in human normal monocytes demonstrated that the 1,25(OH)2D3 VDR ORM1 pathway plays a functional role inside the macrophage de-activation process and that ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. - Highlights: ORM1 is a Vitamin D primary response gene. VD and its receptor VDR are involved in the de-activation process mediated by human resident macrophages. The signaling pathway VD-VDR-ORM1 plays an important role in the control of macrophage de-activation process. ORM1 may be defined as a signaling molecule implicated in the maintenance of tissue homeostasis and remodeling.

  10. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway

    SciTech Connect (OSTI)

    Zhang, Huijuan; Tan, Shi; Wang, Juan; Chen, Shana; Quan, Jing; Xian, Jingrong; Zhang, Shuai shuai; He, Jingang; Zhang, Ling, E-mail: lingzhang@cqmu.edu.cn

    2014-01-01

    The RNA-binding protein Musashi2 (Msi2) has been identified as a master regulator within a variety of stem cell populations via the regulation of translational gene expression. A recent study has suggested that Msi2 is strongly expressed in leukemic cells of acute myeloid leukemia patients, and elevated Msi2 is associated with poor prognosis. However, the potential role of Msi2 in leukemogenesis is still not well understood. Here, we investigated the effect of Msi2 knockdown on the biological properties of leukemic cells. High expression of Msi2 was found in K562 and KG-1a leukemic cell lines, and low expression was observed in the U937 cell line. We transduced K562 cells with two independent adenoviral shRNA vectors targeting Msi2 and confirmed knockdown of Msi2 at the mRNA and protein levels. Msi2 silencing inhibited cell growth and caused cell cycle arrest by increasing the expression of p21 and decreasing the expression of cyclin D1 and cdk2. In addition, knockdown of Msi2 promoted cellular apoptosis via the upregulation of Bax and downregulation of Bcl-2 expression. Furthermore, Msi2 knockdown resulted in the inactivation of the ERK/MAPK and p38/MAPK pathways, but no remarkable change in p-AKT was observed. These data provide evidence that Msi2 plays an important role in leukemogenesis involving the MAPK signaling pathway, which indicates that Msi2 may be a novel target for leukemia treatment. - Highlights: Knockdown of Msi2 inhibited K562 cell growth and arrested cell cycle progression. Knockdown of Msi2 induced K562 cell apoptosis via the regulation of Bax and Bcl-2. The MAPK pathway was involved in the process of Msi2-mediated leukemogenesis. Our data indicate that Msi2 is a potential new target for leukemia treatment.

  11. Exploring the Behavioral and Psychological Differences between Male and Female Youth with a History of Fire Involvement

    E-Print Network [OSTI]

    Morris, Ed M.

    2014-08-31

    Study objectives were to explore a sample of fire-involved youth by 1) describing their overall psychological characteristics, thoughts, and behaviors, 2) comparing the psychological characteristics, thoughts, and behaviors of their male and female...

  12. 6/6/2014 1 of 6 OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals

    E-Print Network [OSTI]

    Kay, Mark A.

    OHS 11-033 revision Animal Research Protocols Involving Hazardous Chemicals I. OVERVIEW Hazardous Chemicals: Known or suspect carcinogens, reproductive toxins or other highly toxic substances (e. Reference the SU Chemical Hygiene Plan for hazardous chemical definitions. Potential Exposures: Research

  13. An Exploration of How Involvement in a Freshman Retention Program Relates to Intention to Complete an Undergraduate Degree

    E-Print Network [OSTI]

    Clounch, Teresa Lynn

    2010-07-15

    The study examined the relationship of the level and type of involvement of freshman students in the Hawk Link Retention Program, a first-year program at the University of Kansas, to intent to return and graduate. The study ...

  14. Finding Common Ground: Exploring the Experiences of Client Involvement in Medication Decisions Using a Shared Decision Making Model

    E-Print Network [OSTI]

    Goscha, Richard J.

    2009-12-01

    medications. Purposeful sampling, with an emphasis on achieving maximum variation, was used to better understand the interactive processes that contribute to as well as hinder client involvement in shared decision making. Multiple interviews with all...

  15. Vitellogenin Receptor and Neuropeptide Receptors Involved in Reproduction of the Red Imported Fire Ant (Solenopsis invicta Buren)

    E-Print Network [OSTI]

    Lu, Hsiao Ling

    2012-02-14

    Social insects have complex forms of social organization. Molecular mechanisms involved in the regulation of their reproduction are not fully understood. This dissertation investigated the vitellogenin receptor (VgR), ...

  16. Community Involvement in the Preservation of World Heritage Sites: The Case of the Ukrainian Carpathian Wooden Churches

    E-Print Network [OSTI]

    Schneider, Hans Rainer

    2013-05-30

    Encouraging the participation of the local population in the preservation of World Heritage Sites is one of the missions of UNESCOs World Heritage Centre. Community involvement is also critical in the planning process. ...

  17. Involvement of voltage-sensitive calcium ion channels in release of luteinizing hormone-releasing hormone from the bovine infundibulum

    E-Print Network [OSTI]

    Dippel, Wendy Wrae

    1993-01-01

    Bovine infundibular explants (INFE) were cultured to confirm calcium (Ca.) and voltage-sensitive calcium channel (VSCC) involvement in luteinizing hormone-releasing hormone (LHRH) release. Mid-sagitally sectioned INFE, randomly assigned to control...

  18. Endovascular Treatment of Infrarenal Abdominal Aortic Lesions With or Without Common Iliac Artery Involvement

    SciTech Connect (OSTI)

    Oender, Hakan; Oguzkurt, Levent; Guer, Serkan; Tekbas, Gueven; Guerel, Kamil; Coskun, Isa; Oezkan, Ugur

    2013-02-15

    To evaluate the results of stent placement for obstructive atherosclerotic aortic disease with or without involvement of the common iliac artery. Forty patients had self-expanding stents primarily or after balloon dilatation in the abdominal aorta between January 2005 and May 2011. All patients had trouble walking. Follow-up examinations were performed with clinical visits; these included color Doppler ultrasonography and computed tomographic angiography. Technical, clinical, and hemodynamic success was achieved in all patients. None of the patients underwent reintervention during the follow-up period, which ranged from 3 months to 6 years (median 24 months). Nine complications occurred in six patients. Of the nine complications, four were distal thromboembolisms, which were successfully treated with catheter-directed thrombolysis or anticoagulation therapy. Endovascular treatment of the obstructive aortic disease using self-expanding stents was safe and effective, with high technical success and long-term patency. Thromboembolic complications were high even though direct stenting was considered protective for thromboembolism formation. Particularly for infrarenal aortic stenosis, it can be recommended as the first-line treatment option for patients with obstructive atherosclerotic aortic disease.

  19. Risk of Developing Cardiovascular Disease After Involved Node Radiotherapy Versus Mantle Field for Hodgkin Lymphoma

    SciTech Connect (OSTI)

    Maraldo, Maja V., E-mail: dra.maraldo@gmail.com [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Brodin, Nils Patrik; Vogelius, Ivan R.; Aznar, Marianne C.; Munck af Rosenschoeld, Per; Petersen, Peter M. [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Specht, Lena [Department of Radiation Oncology, Rigshospitalet, Copenhagen (Denmark); Faculty of Health Sciences, University of Copenhagen, Copenhagen (Denmark)

    2012-07-15

    Purpose: Hodgkin lymphoma (HL) survivors are known to have increased cardiac mortality and morbidity. The risk of developing cardiovascular disease after involved node radiotherapy (INRT) is currently unresolved, inasmuch as present clinical data are derived from patients treated with the outdated mantle field (MF) technique. Methods and Materials: We included all adolescents and young adults with supradiaphragmatic, clinical Stage I-II HL treated at our institution from 2006 to 2010 (29 patients). All patients were treated with chemotherapy and INRT to 30 to 36 Gy. We then simulated a MF plan for each patient with a prescribed dose of 36 Gy. A logistic dose-response curve for the 25-year absolute excess risk of cardiovascular disease was derived and applied to each patient using the individual dose-volume histograms. Results: The mean doses to the heart, four heart valves, and coronary arteries were significantly lower for INRT than for MF treatment. However, the range in doses with INRT treatment was substantial, and for a subgroup of patients, with lymphoma below the fourth thoracic vertebrae, we estimated a 25-year absolute excess risk of any cardiac event of as much as 5.1%. Conclusions: Our study demonstrates a potential for individualizing treatment by selecting the patients for whom INRT provides sufficient cardiac protection for current technology; and a subgroup of patients, who still receive high cardiac doses, who would benefit from more advanced radiation technique.

  20. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis

    SciTech Connect (OSTI)

    Pauly, Markus; Sorensen, Susanne Oxenboll; Harholt, Jesper; Geshi, Naomi; Sakuragi, Yumiko; Moller, Isabel; Zandleven, Joris; Bernal, Adriana J.; Jensen, Niels Bjerg; Sorensen, Charlotte; Jensen, Jacob K.; Beldman, Gerrit; Willats, William G.T.; Scheller, Henrik

    2009-08-19

    Xylogalacturonan (XGA) is a class of pectic polysaccharide found in plant cell walls. The Arabidopsis thaliana locus At5g33290 encodes a predicted Type II membrane protein, and insertion mutants of the At5g33290 locus had decreased cell wall xylose. Immunological studies, enzymatic extraction of polysaccharides, monosaccharide linkage analysis, and oligosaccharide mass profiling were employed to identify the affected cell wall polymer. Pectic XGA was reduced to much lower levels in mutant than in wild-type leaves, indicating a role of At5g33290 in XGA biosynthesis. The mutated gene was designated xylogalacturonan deficient1 (xgd1). Transformation of the xgd1-1 mutant with the wild-type gene restored XGA to wild-type levels. XGD1 protein heterologously expressed in Nicotiana benthamiana catalyzed the transfer of xylose from UDP-xylose onto oligogalacturonides and endogenous acceptors. The products formed could be hydrolyzed with an XGA-specific hydrolase. These results confirm that the XGD1 protein is a XGA xylosyltransferase. The protein was shown by expression of a fluorescent fusion protein in N. benthamiana to be localized in the Golgi vesicles as expected for a glycosyltransferase involved in pectin biosynthesis.

  1. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  2. Fracture Mechanics implications for apparent static friction coefficient in contact problems involving slip-weakening laws

    E-Print Network [OSTI]

    A. Papangelo; M. Ciavarella; J. R. Barber

    2015-06-19

    We consider the effect of differing coefficients of static and dynamic friction coefficients on the behaviour of contacts involving microslip. The classic solutions of Cattaneo and Mindlin are unchanged if the transition in coefficients is abrupt, but if it occurs over some small slip distance, the solution has some mathematical similarities with those governing the normal tractions in adhesive contact problems. In particular, if the transition to dynamic slip occurs over a sufficiently small area, we can identify a `JKR' approximation, where the transition region is condensed to a line. A local singularity in shear traction is then predicted, with a stress-intensity factor that is proportional to the the square root of the local contact pressure and to a certain integral of the friction coefficient-slip distance relation. We can also define an equivalent of the `small-scale yielding' criterion, which enables us to assess when the singular solution provides a good approximation. One consequence of the results is that the static coefficient of friction determined from force measurements in experiments is significantly smaller than the value that holds at the microscale.

  3. Involvement of growth factors and their receptors in radon-induced rat lung tumors

    SciTech Connect (OSTI)

    Leung, F.C.; Dagle, G.E.; Cross, F.T. [Pacific Northwest Lab., Richland, WA (United States)

    1992-12-31

    In this paper we examine the role of growth factors (GF) and their receptors (GFR) in radon-induced rat lung tumors. Inhalation exposure of radon and its daughters induced lung tumors in rats, but the molecule/cellular mechanisms are not known. Recent evidence suggests that GF/GFR play a critical role in the growth and development of lung cancer in humans and animals. We have developed immunocytochemical methods for identifying sites of production and action of GF/GFR at the cellular level; for example, the avidin-biotin horseradish peroxidase technique. In radon-induced rat epidermoid carcinomas, epidermal growth factor (EGF), EGF-receptors (EGF-R), transforming growth factor alpha (TGF-{alpha}), and bombesin were found to be abnormally expressed. These abnormal expressions, mainly associated with epidermoid carcinomas of the lung, were not found in any other lung tumor types. Our data suggest that EGF, EGF-R, TGF-{alpha}, and bombesin are involved in radon oncogenesis in rat lungs, especially in epidermoid carcinomas, possibly through the autocrine/paracrine pathway.

  4. Involvement of Arabidopsis RACK1 in Protein Translation and Its Regulation by Abscisic Acid

    SciTech Connect (OSTI)

    Guo, Jianjun [University of British Columbia, Vancouver; Wang, Shucai [University of British Columbia, Vancouver; Valerius, Oliver [Universitaet Goettingen, Goettingen, Germany; Hall, Hardy [University of British Columbia, Vancouver; Zeng, Qingning [University of British Columbia, Vancouver; Li, Jian-Feng [Harvard University; Weston, David [ORNL; Ellis, Brian [University of British Columbia, Vancouver; Chen, Jay [ORNL

    2011-01-01

    Earlier studies have shown that RACK1 functions as a negative regulator of ABA responses in Arabidopsis, but the molecular mechanism of the action of RACK1 in these processes remains elusive. Global gene expression profiling revealed that approximately 40% of the genes affected by ABA treatment were affected in a similar manner by the rack1 mutation, supporting the view that RACK1 is an important regulator of ABA responses. On the other hand, co-expression analysis revealed that >80% of the genes co-expressed with RACK1 encode ribosome proteins, implying a close relationship between RACK1 s function and the ribosome complex. These results implied that the regulatory role for RACK1 in ABA responses may be partially due to its putative function in protein translation, which is one of the major cellular processes that mammalian and yeast RACK1 is involved in. Consistently, all three Arabidopsis RACK1 homologous genes, namely RACK1A, RACK1B and RACK1C, complemented the growth defects of the S. cerevisiae cpc2/rack1 mutant. In addition, RACK1 physically interacts with Arabidopsis Eukaryotic Initiation Factor 6 (eIF6), whose mammalian homologue is a key regulator of 80S ribosome assembly. Moreover, rack1 mutants displayed hypersensitivity to anisomycin, an inhibitor of protein translation, and displayed characteristics of impaired 80S functional ribosome assembly and 60S ribosomal subunit biogenesis in a ribosome profiling assay. Gene expression analysis revealed that ABA inhibits the expression of both RACK1 and eIF6. Taken together, these results suggest that RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by ABA.

  5. Consent Versus Consensus - Stakehold Involvement in the Identification of Necessary and Sufficient Transportation

    SciTech Connect (OSTI)

    Fawcett, Ricky Lee; Kramer, George Leroy Jr.

    2003-03-01

    Transportation (DOT) and the Nuclear Regulatory Commission (NRC) to provide for the protection of the public and the environment; historically these regulations have proven quite sufficient. Even so, when the Department of Energy (DOE) makes radioactive materials shipments, that are deemed to be a major federal activity, regulations under the National Environmental Policy Act require that public input on safety issues be sought. This requirement leads to interactions with State, Tribal and local stakeholders that often result in the imposition of extra-regulatory requirements requirements beyond those prescribed by DOT and NRC regulations. Unfortunately, these additional requirements virtually always increase costs and delay schedules, and usually do so without significantly increasing, and possibly even decreasing overall transportation safety. We believe that this problem arises because of efforts to achieve stakeholder consensus rather than stakeholder consent, where consensus connotes universal agreement with all aspects of the program, while consent, as used here, is simple agreement with the overall course of action. Gaining consensus entails extensive negotiations because all aspects and requirements of the project must be agreed to by each stakeholder. Gaining consent, on the other hand, requires only that stakeholders be satisfied that the project, as planned, provides adequately for their safety needs. This article addresses the issue of consent versus consensus and proposes a systematic, decision science process for reaching consent. Key steps in this proposed process are early identification and involvement of stakeholders, compilation of their concerns, perceptions, needs, causes, and translation of that information into an appropriate set of derived requirements. These derived requirements, along with already-established DOT and NRC regulatory requirements, form the necessary and sufficient conditions for safe transportation and for obtaining stakeholder consent.

  6. Substrate binding by a bacterial ABC transporter involved in polysaccharide export

    SciTech Connect (OSTI)

    Cuthbertson, Leslie; Kimber, Matthew S.; Whitfield, Chris (Guelph)

    2008-04-02

    ATP-binding-cassette (ABC) transporters are responsible for the export of a wide variety of cell-surface glycoconjugates in both Gram-positive and Gram-negative bacteria. These include the O-antigenic polysaccharide (O-PS) portion of lipopolysaccharide, a crucial virulence determinant in Gram-negative pathogens. O-PSs are synthesized by one of two fundamentally different pathways. Escherichia coli O serotypes O8 and O9a provide the prototype systems for studying O-PS export via ABC transporters. The transporter is composed of the transmembrane component Wzm and the nucleotide-binding component Wzt. Although the N-terminal domain of Wzt is a conventional ABC protein, the C-terminal domain of Wzt (C-Wzt) is a unique structural element that determines the specificity of the transporter for either the O8 or O9a O-PS. We show here that the two domains of Wzt can function when expressed as separate polypeptides; both are essential for export. In vitro, C-Wzt binds its cognate O-PS by recognizing a residue located at the nonreducing end of the polymer. The crystal structure of C-WztO9a is reported here and reveals a {beta} sandwich with an immunoglobulin-like topology that contains the O-PS-binding pocket. Substrate interactions with nucleotide-binding domains have been demonstrated in an ABC exporter previously. However, to our knowledge substrate binding by a discrete, cytoplasmic accessory domain in an extended nucleotide-binding domain polypeptide has not previously been demonstrated. Elucidation of the substrate-recognition system involved in O-PS export provides insight into the mechanism that coordinates polymer biosynthesis, termination, and export.

  7. Involvement of the transcription factor FoxM1 in contact inhibition

    SciTech Connect (OSTI)

    Faust, Dagmar; Al-Butmeh, Firas; Linz, Berenike [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany); Dietrich, Cornelia, E-mail: cdietric@uni-mainz.de [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)] [Institute of Toxicology, Medical Center of the Johannes Gutenberg-University, Obere Zahlbacherstr. 67, 55131 Mainz (Germany)

    2012-10-05

    Highlights: Black-Right-Pointing-Pointer The transcription factor FoxM1 is downregulated upon contact inhibition. Black-Right-Pointing-Pointer The decrease in FoxM1 levels occurs very likely due to inhibition of ERK activity. Black-Right-Pointing-Pointer The decrease in FoxM1 is not sufficient, but required for contact inhibition. Black-Right-Pointing-Pointer We propose a new model of contact inhibition involving pRB/E2F and FoxM1. -- Abstract: Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Although it is generally accepted that contact inhibition plays a pivotal role in maintaining tissue homeostasis, the molecular mechanisms of contact inhibition are still not fully understood. FoxM1 is known as a proliferation-associated transcription factor and is upregulated in many cancer types. Vice versa, anti-proliferative signals, such as TGF-{beta} and differentiation signals decrease FoxM1 expression. Here we investigated the role of FoxM1 in contact inhibition in fibroblasts. We show that protein expression of FoxM1 is severely and rapidly downregulated upon contact inhibition, probably by inhibition of ERK activity, which then leads to decreased expression of cyclin A and polo-like kinase 1. Vice versa, ectopic expression of FoxM1 prevents the decrease in cyclin A and polo-like kinase 1 and causes a two-fold increase in saturation density indicating loss of contact inhibition. Hence, we show that downregulation of FoxM1 is required for contact inhibition by regulating expression of cyclin A and polo-like kinase 1.

  8. Public Involvement Plan Public Involvement Plan

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy BillsNo. 195 - Oct. 7, 2011 | DepartmentFunds for2002 | DepartmentPublic

  9. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    SciTech Connect (OSTI)

    Houseworth, Jim; Rutqvist, Jonny; Asahina, Daisuke; Chen, Fei; Vilarrasa, Victor; Liu, Hui-Hai; Birkholzer, Jens

    2013-11-06

    Nuclear waste programs outside of the US have focused on different host rock types for geological disposal of high-level radioactive waste. Several countries, including France, Switzerland, Belgium, and Japan are exploring the possibility of waste disposal in shale and other clay-rich rock that fall within the general classification of argillaceous rock. This rock type is also of interest for the US program because the US has extensive sedimentary basins containing large deposits of argillaceous rock. LBNL, as part of the DOE-NE Used Fuel Disposition Campaign, is collaborating on some of the underground research laboratory (URL) activities at the Mont Terri URL near Saint-Ursanne, Switzerland. The Mont Terri project, which began in 1995, has developed a URL at a depth of about 300 m in a stiff clay formation called the Opalinus Clay. Our current collaboration efforts include two test modeling activities for the FE heater test and the HG-A leak-off test. This report documents results concerning our current modeling of these field tests. The overall objectives of these activities include an improved understanding of and advanced relevant modeling capabilities for EDZ evolution in clay repositories and the associated coupled processes, and to develop a technical basis for the maximum allowable temperature for a clay repository. The R&D activities documented in this report are part of the work package of natural system evaluation and tool development that directly supports the following Used Fuel Disposition Campaign (UFDC) objectives: ? Develop a fundamental understanding of disposal-system performance in a range of environments for potential wastes that could arise from future nuclear-fuel-cycle alternatives through theory, simulation, testing, and experimentation. ? Develop a computational modeling capability for the performance of storage and disposal options for a range of fuel-cycle alternatives, evolving from generic models to more robust models of performance assessment. For the purpose of validating modeling capabilities for thermal-hydro-mechanical (THM) processes, we developed a suite of simulation models for the planned full-scale FE Experiment to be conducted in the Mont Terri URL, including a full three-dimensional model that will be used for direct comparison to experimental data once available. We performed for the first time a THM analysis involving the Barcelona Basic Model (BBM) in a full three-dimensional field setting for modeling the geomechanical behavior of the buffer material and its interaction with the argillaceous host rock. We have simulated a well defined benchmark that will be used for codeto- code verification against modeling results from other international modeling teams. The analysis highlights the complex coupled geomechanical behavior in the buffer and its interaction with the surrounding rock and the importance of a well characterized buffer material in terms of THM properties. A new geomechanical fracture-damage model, TOUGH-RBSN, was applied to investigate damage behavior in the ongoing HG-A test at Mont Terri URL. Two model modifications have been implemented so that the Rigid-Body-Spring-Network (RBSN) model can be used for analysis of fracturing around the HG-A microtunnel. These modifications are (1) a methodology to compute fracture generation under compressive stress conditions and (2) a method to represent anisotropic elastic and strength properties. The method for computing fracture generation under compressive load produces results that roughly follow trends expected for homogeneous and layered systems. Anisotropic properties for the bulk rock were represented in the RBSN model using layered heterogeneity and gave bulk material responses in line with expectations. These model improvements were implemented for an initial model of fracture damage at the HG-A test. While the HG-A test model results show some similarities with the test observations, differences between the model results and observations remain.

  10. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Lowe, Xiu R

    2009-01-01

    Early brain response to low-dose radiation exposure involvesRunning Title: Low dose radiation affects cognitive functionEarly brain response to low-dose radiation exposure involves

  11. Autism: Reduced Connectivity between Cortical Areas Involved in Face Expression, Theory of Mind, and the Sense of Self

    E-Print Network [OSTI]

    Feng, Jianfeng

    1 Autism: Reduced Connectivity between Cortical Areas Involved in Face Expression, Theory of Mind head: Functional connectivity in autism # These authors contributed equally to this work resting-state functional connectivity was analyzed in 523 people with autism and 452 typically developing

  12. Robotics Minor Robotics is a truly interdisciplinary minor, involving expertise in the fields of computer science, electrical

    E-Print Network [OSTI]

    Massachusetts at Lowell, University of

    Robotics Minor Robotics is a truly interdisciplinary minor, involving expertise in the fields-requisites to the minor courses: Calculus I, Calculus II, Physics I, and Physics II or electricity. Robotics Minor.265 Logic Design 16.317 Microprocessors Systems Design I 22.211 Statics 22.213 Dynamics 22.579 Robotics

  13. Holistic Therapy Holistic Massage: This hour long session involves a complete relaxation of the body while easing

    E-Print Network [OSTI]

    O'Mahony, Donal E.

    Elements Holistic Therapy Clinic Holistic Massage: This hour long session involves a complete. Leaving you re-vitalised, supple and ready for life. 1 hours available. Back, Neck and Shoulders boost Massage: This half an hour session relieves the back of stress knots and stiffness built up within

  14. CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax Production

    E-Print Network [OSTI]

    Kunst, Ljerka

    CER4 Encodes an Alcohol-Forming Fatty Acyl-Coenzyme A Reductase Involved in Cuticular Wax surfaces of land plants. It is composed of a cutin polymer matrix and waxes. Cuticular waxes are complex and characterization of CER4, a wax bio- synthetic gene from Arabidopsis (Arabidopsis thaliana). Arabidopsis cer4

  15. What is Your Environmental Wellness? The environmental dimension involves accepting the impact we have on our world and doing something

    E-Print Network [OSTI]

    What is Your Environmental Wellness? The environmental dimension involves accepting the impact we sprays. _____ 7. I do not litter. _____ 8. I volunteer my time for environmental conservation projects about doing my part to preserve the environment. _____ Total for Environmental Wellness SCORE MEANING 15

  16. Bottomonium spectroscopy and radiative transitions involving the ?[subscript bJ](1P,2P) states at BaBar

    E-Print Network [OSTI]

    Lees, J.?P.

    We use (121 1) million ?(3S) and (98 1) million ?(2S) mesons recorded by the BABAR detector at the PEP-II e[superscript +]e[superscript -] collider at SLAC to perform a study of radiative transitions involving the ...

  17. Identification and characterization of a pyridoxal reductase involved in the vitamin B6 salvage pathway in Arabidopsis

    E-Print Network [OSTI]

    Daub, Margaret

    Identification and characterization of a pyridoxal reductase involved in the vitamin B6 salvage Springer Science+Business Media B.V. 2011 Abstract Vitamin B6 (pyridoxal phosphate) is an essen- tial between the six vitamin B6 vitamers. A putative pyridoxal reductase (PLR1) was identified in Arabidopsis

  18. 162 Electrical and Computer Engineering 163 Courses and projects that actively involve them in their own education and

    E-Print Network [OSTI]

    Richards-Kortum, Rebecca

    A broad education outside of engineering and science that emphasizes the role of electrical and computer162 Electrical and Computer Engineering 163 Courses and projects that actively involve them in their own education and enhance their ability to formulate and solve real-world design and research problems

  19. Supply chain management (SCM) involves the management of materials and information across the entire supply chain. This includes raw material

    E-Print Network [OSTI]

    Calgary, University of

    the entire supply chain. This includes raw material suppliers, component producers, final assemblySupply chain management (SCM) involves the management of materials and information across this concentration will be required to take three core courses: Materials and Supply Chain Management, Transportation

  20. Benzodiazepine Withdrawal-Induced Glutamatergic Plasticity Involves Up-Regulation of GluR1-Containing -Amino-3-

    E-Print Network [OSTI]

    Abraham, Nader G.

    Benzodiazepine Withdrawal-Induced Glutamatergic Plasticity Involves Up-Regulation of GluR1 and addiction. Benzodiazepine withdrawal results in increased glutamatergic strength, but whether -amino-3 remodeled during benzodiazepine withdrawal is uncertain. Whole-cell recordings of rat hippocampal CA1

  1. In this effort, we describe a face database obtained by using an involved acquisition system for the collection of

    E-Print Network [OSTI]

    Abidi, Mongi A.

    relies heavily on illumination. Thermal IR imagery, being a representation of the radiated thermal energy when involving multi-band visible and thermal information. The database has applications/monochromatic image, one thermal image and the spectral distribution of the illumination of the scene. The complete

  2. Distinct osmo-sensing protein kinase pathways are involved in signalling moderate and severe hyper-osmotic

    E-Print Network [OSTI]

    Hirt, Heribert

    Distinct osmo-sensing protein kinase pathways are involved in signalling moderate and severe hyper-osmotic is severely affected by hyper-osmotic salt conditions. Although a number of salt-induced genes have been and extreme hyper-osmotic conditions. A 46 kDa protein kinase was found to be activated by elevated salt

  3. Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping

    E-Print Network [OSTI]

    TDG Transportation of Dangerous Goods Anyone involved with the Transportation of Dangerous Goods must be trained. This includes shipping and receiving. All receiving of Dangerous Goods for the Science in Departmental Offices or labs. How do you know if the package is a dangerous goods shipment? Parcels containing

  4. Whether it's designing rehabilitation strategies involving electricity to `retrain' damaged nerves, developing optical imaging systems to build

    E-Print Network [OSTI]

    Whether it's designing rehabilitation strategies involving electricity to `retrain' damaged nerves-ready rehabilitation products is only part of the equation. As part of her CARE (CREATE Academic Rehabilitation in the commercialization of two important rehabilitation products for the Staxi Corporation.Working out of the iDAPT `Home

  5. The Effects of an Intervention to Foster a Caring and Task-Involving Climate at a University Recreation Center

    E-Print Network [OSTI]

    Brown, Theresa Clare

    2011-04-21

    of the following: a) climate (e.g. perceptions of the caring, task-, and ego-involving climates), b) psychological needs (e.g. autonomy, competence, and relatedness), c) motivational responses (e.g. extrinsic and intrinsic motivation), d) commitment to exercise...

  6. Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

    E-Print Network [OSTI]

    Linial, Michal

    Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release kinase (ERK)/mitogen-activated protein kinase (MAPK) in pardaxin-induced dopamine (DA) release DA release. Time course exper- iments indicated that PX, at nontoxic concentrations, stimu- lated ERK

  7. Planning for multiple mobile robots in dynamic environ-ments involves determining the optimal path each robot

    E-Print Network [OSTI]

    Stentz, Tony

    Abstract Planning for multiple mobile robots in dynamic environ- ments involves determining the optimal path each robot should follow to accomplish the goals of the mission, given the current knowledge reassign robots to goals in order to continually minimize the time to complete the mission. In this paper

  8. A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved in Differentiation of Trypomastigotes to

    E-Print Network [OSTI]

    Singer, Randall

    A Lipid-modified Phosphoinositide-specific Phospholipase C (TcPI-PLC) Is Involved C (PI- PLC) is an important component of the inositol phos- phate/diacylglycerol signaling pathway. A newly discov- ered Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N terminus, targeted

  9. Human Fertilisation and Embryology Bill A briefing for MPs on the need for research involving human and human admixed embryos.

    E-Print Network [OSTI]

    Rambaut, Andrew

    cells for research. The Bill allows research, under license, on four types of HAEs, which contain bothHuman Fertilisation and Embryology Bill A briefing for MPs on the need for research involving human and human admixed embryos. Prepared by the Academy of Medical Sciences, the Medical Research Council

  10. Mass Spectroscopy of Chemical Reaction of 3d Metal Clusters Involved in Chemical Vapor Deposition Synthesis of Carbon Nanotubes

    E-Print Network [OSTI]

    Maruyama, Shigeo

    -labeled experiments. KEYWORDS: cluster, iron, cobalt, nickel, FT-ICR, single-walled carbon nanotubes *Present address Synthesis of Carbon Nanotubes Shuhei Inoue* and Shigeo Maruyama Department of Mechanical Engineering importance. For example, these reactions are involved in the synthesis of single-walled carbon nanotubes

  11. NPS Institutional Review Board (IRB) Interim Guidance on Human Subjects Research Involving Surveys, Questionnaires, Interviews, and Focus Groups

    E-Print Network [OSTI]

    NPS Institutional Review Board (IRB) Interim Guidance on Human Subjects Research Involving Surveys only those data collection activities related to human subjects research. To ensure NPS by the IRB must balance the needs, responsibilities, and risks related to the research subjects, the student

  12. Honours Programmes involving Physics and Astronomy, March 2015 Page 1 Entering SH within Physics and Astronomy and Joint Degrees -2015

    E-Print Network [OSTI]

    Greenaway, Alan

    Honours Programmes involving Physics and Astronomy, March 2015 Page 1 Entering SH within Physics subject to University approvals, we plan to offer BSc Mathematics and Physics students a choice of Maths or Physics project. Some details of the modules open to you are in the University's Course Catalogue

  13. Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius

    E-Print Network [OSTI]

    Anjum, Rana S.; Bray, Sian M.; Blackwood, John K.; Kilkenny, Mairi L.; Coelho, Matthew A.; Foster, Benjamin M.; Li, Shurong; Howard, Julie A.; Pellegrini, Luca; Albers, Sonja-Verena; Deery, Michael J.; Robinson, Nicholas P.

    2015-01-01

    1 Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius. Rana S. Anjum 1*, Sian M. Bray 1*, John K. Blackwood 1, Mairi L. Kilkenny 1, Matthew A. Coelho... , UK. 2) Cambridge Centre for Proteomics, Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. 3) Molecular Biology of Archaea, Max Planck Institute for Terrestrial Microbiology, 35043...

  14. Brief Narrative Description of Research, Teaching, and Service Interests Research: My research involves modeling time-to-event data using flowgraph models.

    E-Print Network [OSTI]

    Huzurbazar, Aparna V.

    for Project AIR FORCE. The main projects involved issues in fleet assessment and programmed depot maintenance, Statistical Inference, Survival Analysis and Logistic Regression, Linear Models, Multivariate Analysis

  15. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development

    E-Print Network [OSTI]

    Lin, Andrew C; Tan, Chin Lik; Lin, Chien-Ling; Strochlic, Laure; Huang, Yi-Shuian; Richter, Joel D; Holt, Christine E

    2009-03-02

    ) RFP/RBM-transfected embryos have bright RFP-positive axons in the optic pathway projecting correctly to the tectum, while RFP/AA-transfected embryos do not. Scale bars: 65 ?m (A, B, M, N); 10 ?m (D, F, J, K); 5 ?m (I). Blue, DAPI; green, CPEB1-GFP... AcceCResearch article Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development Andrew C Lin1,3, Chin Lik Tan1,4, Chien-Ling Lin2, Laure Strochlic1,5, Yi- Shuian...

  16. Characterization of the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast

    SciTech Connect (OSTI)

    Watanabe, Nobuyoshi; Ikeda, Terumasa; Mizuki, Fumitaka [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan)] [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan); Tani, Tokio, E-mail: ttani@sci.kumamoto-u.ac.jp [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan)] [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan)

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer We cloned the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast. Black-Right-Pointing-Pointer The ptr5{sup +} gene was found to encode nucleoporin 85 (Nup85). Black-Right-Pointing-Pointer Seh1p and Mlo3p are multi-copy suppressors for the ptr5 mutation. Black-Right-Pointing-Pointer Ptr5p/Nup85p functions in nuclear mRNA export through the mRNA export factor Rae1p. Black-Right-Pointing-Pointer Ptr5p/Nup85p interacts genetically with pre-mRNA splicing factors. -- Abstract: To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A){sup +} RNA transport] 1 to 11, which accumulate poly(A){sup +} RNA in the nucleus at a nonpermissive temperature in Schizosaccharomyces pombe. Of those, the ptr5-1 mutant shows dots- or a ring-like accumulation of poly(A){sup +} RNA at the nuclear periphery after shifting to the nonpermissive temperature. We cloned the ptr5{sup +} gene and found that it encodes a component of the nuclear pore complex (NPC), nucleoporin 85 (Nup85). The ptr5-1 mutant shows no defects in protein transport, suggesting the specific involvement of Ptr5p/Nup85p in nuclear mRNA export in S. pombe. We identified Seh1p, a nucleoporin interacting with Nup85p, an mRNA-binding protein Mlo3p, and Sac3p, a component of the TREX-2 complex involved in coupling of nuclear mRNA export with transcription, as multi-copy suppressors for the ptr5-1 mutation. In addition, we found that the ptr5-1 mutation is synthetically lethal with a mutation of the mRNA export factor Rae1p, and that the double mutant exaggerates defective nuclear mRNA export, suggesting that Ptr5p/Nup85p is involved in nuclear mRNA export through Rae1p. Interestingly, the ptr5-1 mutation also showed synthetic effects with several prp pre-mRNA splicing mutations, suggesting a functional linkage between the NPCs and the splicing apparatus in the yeast nucleus.

  17. Counting Problems involving Symmetry

    E-Print Network [OSTI]

    Donu Arapura

    2013-04-12

    Group theory can be applied to counting problems invloving symmetry. Here ... problem is to count the set of orbits H/S3. ... a partition of G. By corollary 3.10,.

  18. Counting Problems involving Symmetry*

    E-Print Network [OSTI]

    Group theory can be applied to counting problems invloving symmetry. Here ... problem is to count the set of orbits H/S3. .... a partition of G. By corollary 2.3,.

  19. Parent Involvement (Spanish)

    E-Print Network [OSTI]

    Howard, Jeff W.

    2005-05-10

    Para que un programa de 4-Hh sea exitoso, debe contar con la participaci?n de los padres. Aunque los l?deres de 4-H y los agentes de Extensi?n pueden interesar a los j?venes en ser miembros, necesitan la buena voluntad de los padres y su apoyo para...?deres voluntarios, los agentes de Extensi?n y lo que los miembros del 4-H esperan. Cuando los padres participan solamente super- ficialmente y no se les informa sobre las actividades del club, se puede esperar poca cooperaci?n de ellos. Se debe informar a los...

  20. Commitment to Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAuditsCluster Compatibilitydefault Sign In About | Careers |Create a

  1. TPA Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With LivermoreSustainableDEPARTMENT OFEnergy Innovation

  2. Involvement & Outreach

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you notHeat Pumps Heat PumpsfacilityviaGasforVendors »

  3. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing the RichardBudget and Contracts Committee Chair 1

  4. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing the RichardBudget and Contracts Committee Chair

  5. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing the RichardBudget and Contracts Committee

  6. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing the RichardBudget and Contracts CommitteeRiver

  7. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATIONIntroducing the RichardBudget and Contracts

  8. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Ruben A. Abagyan, PhD

    2004-04-15

    OAK-B135 DNA Damage Recognition and Repair (DDR and R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. the authors have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR and R process. The significant achievements of this project include: (1) Construction of the computational pipeline for searching DDR and R genes, building and validation of 3D models of proteins involved in DDR and R; (2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; (3) Important improvement of macromolecular docking technology and its application to predict the DNA-Protein complex conformation; (4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; (5) Construction and maintenance of the DNA Damage Recognition and Repair Database; and (6) Producing 14 research papers (10 published and 4 in preparation).

  9. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Abagyan, Ruben; An, Jianghong

    2005-08-12

    DNA Damage Recognition and Repair (DDR&R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. We have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR&R process. The significant achievements of this project include: 1) Construction of the computational pipeline for searching DDR&R genes, building and validation of 3D models of proteins involved in DDR&R; 2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; and the development of a method to predict the effects of mutations. Large scale testing of technology to identify novel small binding pockets in protein structures leading to new DDRR inhibitor strategies 3) Improvements of macromolecular docking technology (see the CAPRI 1-3 and 4-5 results) 4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; 5) Construction and maintenance of the DNA Damage Recognition and Repair Database; 6) Producing 15 research papers (12 published and 3 in preparation).

  10. Purely Mechanical Memristors: Perfect Massless Memory Resistors, the Missing Perfect Mass-Involving Memristor, and Massive Memristive Systems

    E-Print Network [OSTI]

    Sascha Vongehr

    2015-08-15

    We define a mechanical analog to the electrical basic circuit element M = d{\\phi}/dQ, namely the ideal mechanical memristance M = dp/dx; p is momentum. We then introduce a mechanical memory resistor which has M(x) independent of velocity v, so it is a perfect (= not-just-memristive) memristor, although its memristance does not crucially involve inert mass. It is practically realizable with a 1cm radius hollow sphere in heavy fuel oil with a temperature gradient. It has a pinched hysteretic loop that collapses at high frequency in the v versus p plot. The mechanical system clarifies the nature of memristor devices that can be hypothesized on grounds of physical symmetries. We hypothesize a missing mechanical perfect memristor, which must be crucially mass-involving (MI) precisely like the 1971 implied EM memristor device needs magnetism. We also construct MI memristive nano systems, which clarifies why perfect MI memristors and EM memristors are still missing and likely impossible.

  11. DOE Technical Standards List. Directory of DOE and contractor personnel involved in non-government standards activities

    SciTech Connect (OSTI)

    NONE

    1997-06-01

    This is a periodic report on the level of agency participation in non-Government standards activities. This technical standards list is intended to assist US Department of Energy (DOE) management and other personnel involved in the DOE technical Standards Program by identifying those participating individuals. The body of this document contains a listing of DOE employees and DOE contractors who have submitted a Record of Non-Government Standards Activity. Additional names were added from rosters supplied by non-Government standards bodies. Appendices to this document are provided to list the information by parent employment organization, by non-Government standards activity, and by the proper names of the non-Government standards organizations and committees.

  12. DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

    SciTech Connect (OSTI)

    Tsujimoto, Y.; Bashir, M.M.; Givol, I.; Cossman, J.; Jaffe, E.; Croce, C.M.

    1987-03-01

    In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.

  13. Selection of potential IAEA inspection strategies involving cascade access at the Portsmouth Gas Centrifuge Enrichment Plant (GCEP)

    SciTech Connect (OSTI)

    Not Available

    1981-04-13

    This report has been prepared as a US contribution to Team 4 of the Hexapartite Safeguards Project. It provides to the Team 4 participants one example of an approach, which has been used in the United States, to developing a range of safeguards strategies involving differing degrees of access to cascade areas of centrifuge enrichment plants. Its purpose is to facilitate the work of other Hexapartite participants in completing Task II of Team 4's terms of reference. The scope of this report is limited to identifying safeguards approaches for the Portsmouth Gas Centrifuge Enrichment Plant (GCEP) which involve differing degrees of access to the cascade area. This report provides a method for selecting cascade access inspection strategies at GCEP which appear promising for more detailed evaluation. It is quite important to note, however, that the effectiveness and practicability of these strategies have not been established at the present. In addition, some strategies have been included on the basis of very preliminary calculations and considerations which have not been validated. Thus, some of these strategies may ultimately be rejected because they prove to be impracticable. Considerations of cost and the possible transfer of information and technology related to the production of enriched uranium will also be pertinent in considering the degrees and frequency of access to the cascade areas of centrifuge enrichment plants. This report describes the process for combining technical measures, implementation approaches and objectives to arrive at the total number of theoretically possible combinations. It then describes how these combinations may be reduced in a series of steps to a number that is more manageable for detailed evaluation. The process is shown schematically.

  14. Involvement of caspase-12-dependent apoptotic pathway in ionic radiocontrast urografin-induced renal tubular cell injury

    SciTech Connect (OSTI)

    Wu, Cheng Tien [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Weng, Te I. [Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Chen, Li Ping [Department of Dentistry, Chang Gang Memorial Hospital, Chang Gang University, Taoyuan, Taiwan (China)] [Department of Dentistry, Chang Gang Memorial Hospital, Chang Gang University, Taoyuan, Taiwan (China); Chiang, Chih Kang [Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China) [Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Liu, Shing Hwa, E-mail: shinghwaliu@ntu.edu.tw [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Department of Urology, National Taiwan University Hospital, Taipei, Taiwan (China)

    2013-01-01

    Contrast medium (CM) induces a direct toxic effect on renal tubular cells. This toxic effect subjects in the disorder of CM-induced nephropathy. Our previous work has demonstrated that CM shows to activate the endoplasmic reticulum (ER)-related adaptive unfolding protein response (UPR) activators. Glucose-regulated protein 78 (GRP78)/eukaryotic initiation factor 2? (eIF2?)-related pathways play a protective role during the urografin (an ionic CM)-induced renal tubular injury. However, the involvement of ER stress-related apoptotic signals in the urografin-induced renal tubular cell injury remains unclear. Here, we examined by the in vivo and in vitro experiments to explore whether ER stress-regulated pro-apoptotic activators participate in urografin-induced renal injury. Urografin induced renal tubular dilation, tubular cells detachment, and necrosis in the kidneys of rats. The tubular apoptosis, ER stress-related pro-apoptotic transcriptional factors, and kidney injury marker-1 (kim-1) were also conspicuously up-regulated in urografin-treated rats. Furthermore, treatment of normal rat kidney (NRK)-52E tubular cells with urografin augmented the expressions of activating transcription factor-6 (ATF-6), C/EBP homologous protein (CHOP), Bax, caspase-12, JNK, and inositol-requiring enzyme (IRE) 1 signals. Urografin-induced renal tubular cell apoptosis was not reversed by the inhibitors of ATF-6, JNK signals or CHOP siRNA transfection, but it could be partially reversed by the inhibitor of caspase-12. Taken together, the present results and our previous findings suggest that exposure of CM/urografin activates the ER stress-regulated survival- and apoptosis-related signaling pathways in renal tubular cells. Caspase-12-dependent apoptotic pathway may be partially involved in the urografin-induced nephropathy. -- Highlights: ? Ionic contrast medium-urografin induces renal tubular cell apoptosis. ? Urografin induces the ER stress-regulated survival and apoptosis signals. ? Caspase-12 signaling participates in urografin-induced renal cell apoptosis.

  15. Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich peptide and methionine sulfoxide reductase

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Melnyk, Ryan A.; Youngblut, Matthew D.; Clark, Iain C.; Carlson, Hans K.; Wetmore, Kelly M.; Price, Morgan N.; Lavarone, Anthony T.; Deutschbauer, Adam M.; Arkin, Adam P.; Coates, John D.

    2015-05-12

    Reactive chlorine species (RCS) defense mechanisms are important for bacterial fitness in diverse environments. In addition to the anthropogenic use of RCS in the form of bleach, these compounds are also produced naturally through photochemical reactions of natural organic matter and in vivo by the mammalian immune system in response to invading microorganisms. To gain insight into bacterial RCS defense mechanisms, we investigated Azospira suillum strain PS, which produces periplasmic RCS as an intermediate of perchlorate respiration. Our studies identified an RCS response involving an RCS stress-sensing sigma/anti-sigma factor system (SigF/NrsF), a soluble hypochlorite-scavenging methionine-rich periplasmic protein (MrpX), and amoreputative periplasmic methionine sulfoxide reductase (YedY1). We investigated the underlying mechanism by phenotypic characterization of appropriate gene deletions, chemogenomic profiling of barcoded transposon pools, transcriptome sequencing, and biochemical assessment of methionine oxidation. Our results demonstrated that SigF was specifically activated by RCS and initiated the transcription of a small regulon centering around yedY1 and mrpX. A yedY1 paralog (yedY2) was found to have a similar fitness to yedY1 despite not being regulated by SigF. Markerless deletions of yedY2 confirmed its synergy with the SigF regulon. MrpX was strongly induced and rapidly oxidized by RCS, especially hypochlorite. Our results suggest a mechanism involving hypochlorite scavenging by sacrificial oxidation of the MrpX in the periplasm. Reduced MrpX is regenerated by the YedY methionine sulfoxide reductase activity. The phylogenomic distribution of this system revealed conservation in several Proteobacteria of clinical importance, including uropathogenic Escherichia coli and Brucella spp., implying a putative role in immune response evasion in vivo. In addition, bacteria are often stressed in the environment by reactive chlorine species (RCS) of either anthropogenic or natural origin, but little is known of the defense mechanisms they have evolved. Using a microorganism that generates RCS internally as part of its respiratory process allowed us to uncover a novel defense mechanism based on RCS scavenging by reductive reaction with a sacrificial methionine-rich peptide and redox recycling through a methionine sulfoxide reductase. This system is conserved in a broad diversity of organisms, including some of clinical importance, invoking a possible important role in innate immune system evasion.less

  16. Projecting Fatalities in Crashes Involving Older Drivers, 20002025, CRADA No. ORNL98-0500 Final Report

    SciTech Connect (OSTI)

    Hu, Patricia S. [ORNL] [ORNL; Jones, Donald W. [ORNL] [ORNL; Reuscher, Timothy [Oak Ridge Institute for Science and Education] [Oak Ridge Institute for Science and Education; Schmoyer, Richard S. [ORNL] [ORNL; Truett, Lorena F. [ORNL] [ORNL

    2000-04-01

    At the turn of the century the 20th century that is the median age in the United States was under 30 years; America was 60% rural in nature; and there were only 36 highway fatalities all year. As we leave the 20th century behind, the route into the 21st century is very different. Intelligent cars speed down multi-lane smart highways in a nation that is 75% urban. According to the Federal Highway Administrations Highway Statistics, there are 28,000 times more vehicles on the road in 2000 than there were in 1900, and these vehicles travel about 2.6 trillion miles each year. Annual fatalities resulting from highway crashes have also increased by over 1100%. We see other changes as well. The face of America is changing. It is growing older. In 2025, persons 65 and over will make up 18.5% of the total population. The number of persons aged 85 and over is increasing more rapidly than any other age group. More importantly, the elderly are taking more trips, driving further, and continuing to drive much later in life. These conditions lead to concerns about traffic safety. Although the elderly are healthier and drive safer cars than they did just two decades ago, their frailty makes them more susceptible to injury than younger persons involved in traffic crashes of the same severity. In addition, visual, physical, and cognitive skills, all of which contribute to driving abilities, decrease with advancing age. The familiar U-shaped curve depicting the rate of fatalities per vehicle miles traveled, shows that the elderly experience a higher highway fatality rate than any other age group except teenagers. While the overall number of highway fatalities has decreased regularly since 1972, the number of fatalities of elderly travelers has continued to increase steadily. This increase is cause for concern for both the elderly driver and for other persons on the roads who migh tbe placed in danger through crashes involving elderly drivers.

  17. Accurate Computer Simulation of Phase Equilibrium for Complex Fluid Mixtures. Application to Binaries Involving Isobutene, Methanol, Methyl tert-Butyl Ether, and

    E-Print Network [OSTI]

    Lisal, Martin

    to Binaries Involving Isobutene, Methanol, Methyl tert-Butyl Ether, and n-Butane Martin Lisal,*,, William R + methyl tert-butyl ether (MTBE) and the binaries formed by methanol with isobutene, MTBE, and n

  18. University of Twente Scientific Integrity Complaints Procedure Within the University of Twente all persons involved in education and research have a personal

    E-Print Network [OSTI]

    Boucherie, Richard J.

    (the suspicion of) a violation of scientific integrity by an employee Complainant: A person whoUniversity of Twente Scientific Integrity Complaints Procedure Preamble Within the University of Twente all persons involved in education and research have a personal responsibility

  19. Visible light stimulating dual-wavelength emission and O vacancy involved energy transfer behavior in luminescence for coaxial nanocable arrays

    SciTech Connect (OSTI)

    Yang, Lei, E-mail: nanoyang@qq.com [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Hunan Province Key Laboratory for Spray Deposition Technology and Application, Hunan University, Changsha 410082 (China); Dong, Jiazhang; Jiang, Zhongcheng [College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Pan, Anlian; Zhuang, Xiujuan [Key Laboratory for Micro-Nano Physics and Technology of Hunan Province, Hunan University, Changsha 410082 (China)

    2014-06-14

    We report a strategy to investigate O vacancy (V{sub O}) involved energy transfer and dual-wavelength yellow emission in coaxial nanocable. By electric field deposition and subsequent sol-gel template approach, ZnO:Tb/Y{sub 2}O{sub 3}:Eu coaxial nanocable arrays are synthesized. After visible light excitation, system is promoted to O vacancy charge transfer state of V{sub O}(0/+). In the following cross relaxation, energy transfer from V{sub O} to the excitation energy level of Tb{sup 3+} in ZnO:Tb core area. While in Y{sub 2}O{sub 3}:Eu shell area, energy transfer to the excitation energy level of Eu{sup 3+}. Subsequently, dual-wavelength emission is observed. By constructing nanocable with dual-wavelength emission, yellow luminescence is obtained. Adjust doping concentration of Eu{sup 3+} or Tb{sup 3+} in the range of 0.010.05, chromaticity coordinates of ZnO:Tb/Y{sub 2}O{sub 3}:Eu nanocable stably stays at yellow region in color space except ZnO:Tb{sub 0.01}/Y{sub 2}O{sub 3}:Eu{sub 0.01}. As Vo states act as media in energy transfer process in nanocablers, visible light can stimulate dual-wavelength emissions. Yellow luminescent nanocable arrays will have great applications in light-emitting diode luminescence.

  20. Bottomonium spectroscopy and radiative transitions involving the chi_bJ(1P,2P) states at BABAR

    E-Print Network [OSTI]

    J. P. Lees; for the BABAR Collaboration

    2014-10-16

    We use $(121\\pm1)$ million $\\Upsilon(3S)$ and $(98\\pm1)$ million $\\Upsilon(2S)$ mesons recorded by the BABAR detector at the PEP-II $e^+e^-$ collider at SLAC to perform a study of radiative transitions involving the $\\chi_{b\\mathrm{J}}(1P,2P)$ states in exclusive decays with $\\mu^+\\mu^-\\gamma\\gamma$ final states. We reconstruct twelve channels in four cascades using two complementary methods. In the first we identify both signal photon candidates in the Electromagnetic Calorimeter (EMC), employ a calorimeter timing-based technique to reduce backgrounds, and determine branching-ratio products and fine mass splittings. These results include the best observational significance yet for the $\\chi_{b0}(2P)\\rightarrow\\gamma\\Upsilon(2S)$ and $\\chi_{b0}(1P)\\rightarrow\\gamma\\Upsilon(1S)$ transitions. In the second method, we identify one photon candidate in the EMC and one which has converted into an $e^+e^-$ pair due to interaction with detector material, and we measure absolute product branching fractions. This method is particularly useful for measuring $\\Upsilon(3S)\\rightarrow\\gamma\\chi_{b1,2}(1P)$ decays. Additionally, we provide the most up-to-date derived branching fractions, matrix elements and mass splittings for $\\chi_b$ transitions in the bottomonium system. Using a new technique, we also measure the two lowest-order spin-dependent coefficients in the nonrelativistic QCD Hamiltonian.

  1. G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis

    SciTech Connect (OSTI)

    Shi, Yanan; Liu, Xiaochun; Zhu, Pei; Li, Jianzhen; Sham, Kathy W.Y.; Cheng, Shuk Han; Li, Shuisheng; Zhang, Yong; Cheng, Christopher H.K.; Lin, Haoran; College of Ocean, Hainan University, Haikou 570228, Hainan

    2013-05-24

    Highlights: The Gper expression was detected in the developing brain of zebrafish. Gper morpholino knockdown induced apoptosis of brain cells. Gper morpholino knockdown reduced expression in neuron markers. Zebrafish Gper may be involved in neuronal development. -- Abstract: G-protein-coupled estrogen receptor 1 (Gper, formerly known as GPR30) is found to be a trophic and protective factor in mediating action of estrogen in adult brain, while its role in developing brain remains to be elucidated. Here we present the expression pattern of Gper and its functions during embryogenesis in zebrafish. Both the mRNA and protein of Gper were detected throughout embryogenesis. Whole mount in situ hybridization (WISH) revealed a wide distribution of gper mRNAs in various regions of the developing brain. Gper knockdown by specific morpholinos resulted in growth retardation in embryos and morphological defects in the developing brain. In addition, induced apoptosis, decreased proliferation of the brain cells and maldevelopment of sensory and motor neurons were also found in the morphants. Our results provide novel insights into Gper functions in the developing brain, revealing that Gper can maintain the survival of the brain cells, and formation and/or differentiation of the sensory and motor neurons.

  2. Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

    SciTech Connect (OSTI)

    Lai, Serene R.; Cunningham, Amanda P.; Huynh, Vu Q.; Andrews, Lucy G.; Tollefsbol, Trygve O. . E-mail: trygve@uab.edu

    2007-01-15

    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cycle and on its own regulatory proteins, specifically: p53 and p21. We tested our hypothesis that hTERT regulates its own expression through effects on upstream regulatory genes using transformed human embryonic kidney (HEK 293) cells, p53 and p16 {sup INK4a} null human ovarian cancer SKOV-3 cells, and p53-null MDA-MB-157 human mammary cancer cells. In HEK 293 cells, hTERT knockdown resulted in elevated p53 and p21 transcription and a decrease in cellular proliferation. Similar results were observed in the MDA-MB-157 cell line where p21 was upregulated, correlating with cell growth inhibition. In contrast, we observed a decrease in expression of p21 in SKOV-3 cells with hTERT knockdown and cell growth appeared to be unaffected. These findings suggest that hTERT may be involved in a feedback loop system, thereby playing a role in its own regulation.

  3. H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove

    SciTech Connect (OSTI)

    Walter, W.; Loos, M.; Maeurer, M.J.

    1996-12-31

    The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibility I-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequenced H2-Ma, H2-Mb1, and H2-Mb2 genes from CIA-susceptible and -resistant mouse strains and identified four different Ma and Mb2 alleles, and three different Mb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share common Ma, Mb1, and Mb2 alleles. In contrast, H2-M alleles designated Ma-III, Ma-IV, Mb1-III, and Mb2-IV could be exclusively identified in the CIA-susceptible H2{sup r} and H2{sup q} haplotypes, suggesting that allelic H2-M molecules may modulate the composition of different CII peptides loaded onto MHC class II molecules, presumably presenting {open_quotes}arthritogenic{close_quotes} epitopes to T lymphocytes. 42 refs., 4 figs., 3 tabs.

  4. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans

    SciTech Connect (OSTI)

    Iwasa, Hiroaki [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Maimaiti, Sainawaer [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Department of Psychotherapy, The Fourth People's Hospital of Urumqi, Urumqi 830000 (China); Kuroyanagi, Hidehito [Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Kawano, Shodai; Inami, Kazutoshi; Timalsina, Shikshya; Ikeda, Mitsunobu; Nakagawa, Kentaro [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Hata, Yutaka, E-mail: yuhammch@tmd.ac.jp [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan)

    2013-04-15

    The mammalian Hippo pathway comprises mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2). LATS1/2, which are activated by MST1/2, phosphorylate a transcriptional co-activator, yes-associated protein (YAP), and induce the recruitment of YAP by 14-3-3 to cytoplasm, so that the TEAD-dependent gene transcriptions are turned off. Although the core components of the Hippo pathway are well conserved in metazoans, it has been discussed that Caenorhabditis elegans lacks YAP ortholog, we found that F13E6.4 gene encodes a protein that shows sequence similarities to YAP in the N-terminal TEAD-binding domain and in the WW domain. We designated this gene as yap-1. YAP-1 is widely expressed in various cells such as epithelial cells, muscles, hypodermal cells, gonadal sheath cells, spermatheca, and hypodermal cells. YAP-1 is distributed in cytoplasm and nuclei. wts-1 (LATS ortholog) and ftt-2 (14-3-3 ortholog) knockdowns cause nuclear accumulation of YAP-1, supporting that the subcellular localization of YAP-1 is regulated in a similar way as that of YAP. Heat shock also causes the nuclear accumulation of YAP-1 but after heat shock, YAP-1 translocates to cytoplasm. Knockdowns of DAF-21 (HSP90 ortholog) and HSF-1block the nuclear export of YAP-1 during this recovery. YAP-1 overexpression is beneficial for thermotolerance, whereas YAP-1 hyperactivity induced by wts-1 and ftt-2 knockdowns is deleterious on thermal response and yap-1 deficiency promotes health aging. In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. - Highlights: ? We named Caenorhabditis elegans F13E6.4 gene yap-1 as a putative YAP homolog. ? The localization of YAP-1 is regulated by WTS-1 and FTT-2. ? YAP-1 is involved in healthy aging and thermosensitivity.

  5. An extracytoplasmic function sigma factor-dependent periplasmic glutathione peroxidase is involved in oxidative stress response of Shewanella oneidensis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dai, Jingcheng; Wei, Hehong; Tian, Chunyuan; Damron, Fredrick; Zhou, Jizhong; Qiu, Dongru

    2015-01-01

    Background: Bacteria use alternative sigma factors (?s) to regulate condition-specific gene expression for survival and Shewanella harbors multiple ECF (extracytoplasmic function) ? genes and cognate anti-sigma factor genes. Here we comparatively analyzed two of the rpoE-like operons in the strain MR-1: rpoE-rseA-rseB-rseC and rpoE2-chrR. Results: RpoE was important for bacterial growth at low and high temperatures, in the minimal medium, and high salinity. The degP/htrA orthologue, required for growth of Escherichia coli and Pseudomonas aeruginosa at high temperature, is absent in Shewanella, while the degQ gene is RpoE-regulated and is required for bacterial growth at high temperature. RpoE2 was essentialmorefor the optimal growth in oxidative stress conditions because the rpoE2 mutant was sensitive to hydrogen peroxide and paraquat. The operon encoding a ferrochelatase paralogue (HemH2) and a periplasmic glutathione peroxidase (PgpD) was identified as RpoE2-dependent. PgpD exhibited higher activities and played a more important role in the oxidative stress responses than the cytoplasmic glutathione peroxidase CgpD under tested conditions. The rpoE2-chrR operon and the identified regulon genes, including pgpD and hemH2, are coincidently absent in several psychrophilic and/or deep-sea Shewanella strains. Conclusion: In S. oneidensis MR-1, the RpoE-dependent degQ gene is required for optimal growth under high temperature. The rpoE2 and RpoE2-dependent pgpD gene encoding a periplasmic glutathione peroxidase are involved in oxidative stress responses. But rpoE2 is not required for bacterial growth at low temperature and it even affected bacterial growth under salt stress, indicating that there is a tradeoff between the salt resistance and RpoE2-mediated oxidative stress responses.less

  6. The Impact of Extent and Location of Mediastinal Lymph Node Involvement on Survival in Stage III Non-Small Cell Lung Cancer Patients Treated With Definitive Radiotherapy

    SciTech Connect (OSTI)

    Fernandes, Annemarie T.; Mitra, Nandita; Xanthopoulos, Eric; Evans, Tracey; Stevenson, James; Langer, Corey; Kucharczuk, John C.; Lin, Lilie; Rengan, Ramesh

    2012-05-01

    Purpose: Several surgical series have identified subcarinal, contralateral, and multilevel nodal involvement as predictors of poor overall survival in patients with Stage III non-small-cell lung cancer (NSCLC) treated with definitive resection. This retrospective study evaluates the impact of extent and location of mediastinal lymph node (LN) involvement on survival in patients with Stage III NSCLC treated with definitive radiotherapy. Methods and Materials: We analyzed 106 consecutive patients with T1-4 N2-3 Stage III NSCLC treated with definitive radiotherapy at University of Pennsylvania between January 2003 and February 2009. For this analysis, mediastinal LN stations were divided into four mutually exclusive groups: supraclavicular, ipsilateral mediastinum, contralateral mediastinum, and subcarinal. Patients' conditions were then analyzed according to the extent of involvement and location of mediastinal LN stations. Results: The majority (88%) of patients received sequential or concurrent chemotherapy. The median follow-up time for survivors was 32.6 months. By multivariable Cox modeling, chemotherapy use (hazard ratio [HR]: 0.21 [95% confidence interval (CI): 0.07-0.63]) was associated with improved overall survival. Increasing primary tumor [18F]-fluoro-2-deoxy-glucose avidity (HR: 1.11 [CI: 1.06-1.19]), and subcarinal involvement (HR: 2.29 [CI: 1.11-4.73]) were significant negative predictors of overall survival. On univariate analysis, contralateral nodal involvement (HR: 0.70 [CI: 0.33-1.47]), supraclavicular nodal involvement (HR: 0.78 [CI: 0.38-1.67]), multilevel nodal involvement (HR: 0.97 [CI: 0.58-1.61]), and tumor size (HR: 1.04 [CI: 0.94-1.14]) did not predict for overall survival. Patients with subcarinal involvement also had lower rates of 2-year nodal control (51.2% vs. 74.9%, p = 0.047) and 2-year distant control (28.4% vs. 61.2%, p = 0.043). Conclusions: These data suggest that the factors that determine oncologic outcome in Stage III NSCLC patients treated with definitive radiotherapy are distinct from those observed in patients who undergo surgical resection. The ultimate efficacy of radiation in locally advanced NSCLC is dependent on the intrinsic biology of the tumor.

  7. Buried pipelines essentially involve problems of soil-structure interaction that include several complex factors such as geometry, material properties, and boundary

    E-Print Network [OSTI]

    Al-Shayea, Naser Abdul-Rahman

    1 Abstract Buried pipelines essentially involve problems of soil-structure interaction that include Bend, and Buckling Check. Keywords: buried pipelines, regression, horizontal bend, vertical bend, homoscedasticity, normality. 1 Introduction Analysis and design of buried pipelines are usually based on classical

  8. Rea1, a Dynein-related Nuclear AAA-ATPase, Is Involved in Late rRNA Processing and Nuclear Export of 60 S Subunits*S

    E-Print Network [OSTI]

    Nissan, Tracy

    Rea1, a Dynein-related Nuclear AAA-ATPase, Is Involved in Late rRNA Processing and Nuclear Export we report that Rea1 is required for maturation and nuclear export of the pre-60 S subunit. Rea1. Using an in vivo 60 S subunit export assay, a strong accumulation of the large subunit reporter Rpl25

  9. In an international collaboration, Drs Thomas Roscoe and Ljerka Kunst are developing powerful genetic approaches to identify the mechanisms involved in regulating oil production in seeds. Their

    E-Print Network [OSTI]

    genetic approaches to identify the mechanisms involved in regulating oil production in seeds in the regulation of seed oil production in the embryo by the French team; third, the discovery of new information. Their exciting work will lead to the development of new crops for biofuel production As joint project

  10. LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9

    E-Print Network [OSTI]

    Lee, Won-Ha

    LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro inflammation and cartilage destruction.79 LIGHT (TNFSF14) is a member of tumor necrosis factor superfamily and is the ligand for TR2 (TNFRSF14/HVEM/ HveA/LIGHTR/ATAR) and lymphotoxin (LT)-b.1012 LIGHT is known

  11. In Vitro Drug Sensitivity-Gene Expression Correlations Involve a Tissue of Origin C. R. Andersson, M. Fryknas, L. Rickardson, R. Larsson, A. Isaksson, and

    E-Print Network [OSTI]

    In Vitro Drug Sensitivity-Gene Expression Correlations Involve a Tissue of Origin Dependency C. R concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles

  12. How Reliable are Parallel Disk Systems When Energy-Saving Schemes are Involved? Shu Yin, Xiaojun Ruan, Adam Manzanares, and Xiao Qin

    E-Print Network [OSTI]

    Qin, Xiao

    How Reliable are Parallel Disk Systems When Energy-Saving Schemes are Involved? Shu Yin, Xiaojun, growing evidence shows that energy-saving schemes in disk drives usually have negative impacts on storage - called MINT - to evaluate the reliability of a parallel disk system where energy-saving mechanisms

  13. Value of Citizen Science Monitoring Involving citizen scientists in the sea star wasting disease survey effort will greatly expand our spatial

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    Value of Citizen Science Monitoring Involving citizen scientists in the sea star wasting disease survey effort will greatly expand our spatial and temporal coverage. Citizen science groups can collect. A researcher from the MARINe group should accompany each citizen science group in the field to assist

  14. Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus

    SciTech Connect (OSTI)

    Banerjee, Chaitali [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Goswami, Ramansu [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Centre for Environmental Studies, Visva-Bharati University, Santiniketan 731 235 (India); Datta, Soma [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Rajagopal, R. [Gut Biology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Mazumder, Shibnath, E-mail: shibnath1@yahoo.co.in [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India)

    2011-10-01

    We had earlier shown that exposure to arsenic (0.50 {mu}M) caused caspase-3 mediated head kidney macrophage (HKM) apoptosis involving the p38-JNK pathway in Clarias batrachus. Here we examined the roles of calcium (Ca{sup 2+}) and extra-cellular signal-regulated protein kinase (ERK), the other member of MAPK-pathway on arsenic-induced HKM apoptosis. Arsenic-induced HKM apoptosis involved increased expression of ERK and calpain-2. Nifedipine, verapamil and EGTA pre-treatment inhibited the activation of calpain-2, ERK and reduced arsenic-induced HKM apoptosis as evidenced from reduced caspase-3 activity, Annexin V-FITC-propidium iodide and Hoechst 33342 staining. Pre-incubation with ERK inhibitor U 0126 inhibited the activation of calpain-2 and interfered with arsenic-induced HKM apoptosis. Additionally, pre-incubation with calpain-2 inhibitor also interfered with the activation of ERK and inhibited arsenic-induced HKM apoptosis. The NADPH oxidase inhibitor apocynin and diphenyleneiodonium chloride also inhibited ERK activation indicating activation of ERK in arsenic-exposed HKM also depends on signals from NADPH oxidase pathway. Our study demonstrates the critical role of Ca{sup 2+} homeostasis on arsenic-induced HKM apoptosis. We suggest that arsenic-induced alteration in intracellular Ca{sup 2+} levels initiates pro-apoptotic ERK and calpain-2; the two pathways influence each other positively and induce caspase-3 mediated HKM apoptosis. Besides, our study also indicates the role of ROS in the activation of ERK pathway in arsenic-induced HKM apoptosis in C. batrachus. - Highlights: > Altered Ca{sup 2+} homeostasis leads to arsenic-induced HKM apoptosis. > Calpain-2 plays a critical role in the process. > ERK is pro-apoptotic in arsenic-induced HKM apoptosis. > Arsenic-induced HKM apoptosis involves cross talk between calpain-2 and ERK.

  15. Rate Adjustments and Public Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Letter to South Texas Electric Coop., Inc requesting an extension of the existing rate formula FalconAmistad WAPA-143 FERC Approval FalconAmistad Published WAPA-143 Falcon...

  16. Cyber Incidents Involving Control Systems

    SciTech Connect (OSTI)

    Robert J. Turk

    2005-10-01

    The Analysis Function of the US-CERT Control Systems Security Center (CSSC) at the Idaho National Laboratory (INL) has prepared this report to document cyber security incidents for use by the CSSC. The description and analysis of incidents reported herein support three CSSC tasks: establishing a business case; increasing security awareness and private and corporate participation related to enhanced cyber security of control systems; and providing informational material to support model development and prioritize activities for CSSC. The stated mission of CSSC is to reduce vulnerability of critical infrastructure to cyber attack on control systems. As stated in the Incident Management Tool Requirements (August 2005) ''Vulnerability reduction is promoted by risk analysis that tracks actual risk, emphasizes high risk, determines risk reduction as a function of countermeasures, tracks increase of risk due to external influence, and measures success of the vulnerability reduction program''. Process control and Supervisory Control and Data Acquisition (SCADA) systems, with their reliance on proprietary networks and hardware, have long been considered immune to the network attacks that have wreaked so much havoc on corporate information systems. New research indicates this confidence is misplaced--the move to open standards such as Ethernet, Transmission Control Protocol/Internet Protocol, and Web technologies is allowing hackers to take advantage of the control industry's unawareness. Much of the available information about cyber incidents represents a characterization as opposed to an analysis of events. The lack of good analyses reflects an overall weakness in reporting requirements as well as the fact that to date there have been very few serious cyber attacks on control systems. Most companies prefer not to share cyber attack incident data because of potential financial repercussions. Uniform reporting requirements will do much to make this information available to Department of Homeland Security (DHS) and others who require it. This report summarizes the rise in frequency of cyber attacks, describes the perpetrators, and identifies the means of attack. This type of analysis, when used in conjunction with vulnerability analyses, can be used to support a proactive approach to prevent cyber attacks. CSSC will use this document to evolve a standardized approach to incident reporting and analysis. This document will be updated as needed to record additional event analyses and insights regarding incident reporting. This report represents 120 cyber security incidents documented in a number of sources, including: the British Columbia Institute of Technology (BCIT) Industrial Security Incident Database, the 2003 CSI/FBI Computer Crime and Security Survey, the KEMA, Inc., Database, Lawrence Livermore National Laboratory, the Energy Incident Database, the INL Cyber Incident Database, and other open-source data. The National Memorial Institute for the Prevention of Terrorism (MIPT) database was also interrogated but, interestingly, failed to yield any cyber attack incidents. The results of this evaluation indicate that historical evidence provides insight into control system related incidents or failures; however, that the limited available information provides little support to future risk estimates. The documented case history shows that activity has increased significantly since 1988. The majority of incidents come from the Internet by way of opportunistic viruses, Trojans, and worms, but a surprisingly large number are directed acts of sabotage. A substantial number of confirmed, unconfirmed, and potential events that directly or potentially impact control systems worldwide are also identified. Twelve selected cyber incidents are presented at the end of this report as examples of the documented case studies (see Appendix B).

  17. Classified Visits Involving Foreign Nationals

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-01-13

    The Order establishes a program to manage the Department-wide program to facilitate, document, and assure accountability when approving foreign national access to classified DOE programs and facilities. Cancels portions of Chapter VIII, of DOE O 470.1 that pertain to foreign nationals who visit DOE sitess and require access to classified information. Canceled by DOE O 470.4B.

  18. Who's Involved | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-Sessions |discussed how saving energy could betold youExamples White2014 DOE CFC

  19. Appendix V Public Involvement Plan

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouth DakotaRobbins and700, 1. .&. ' ,ALASKAAlternate3 ThroughABV

  20. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of ASCR

  1. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of ASCRDecember 10,

  2. Public Involvement Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of ASCRDecember

  3. Public Involvement and Communications Committee:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 201211,Page

  4. Public Involvment Plan - Rifle, Colorado

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouthReport for the t-) S/,,5 'a C O M1 the RFSOGorPLEASE RETURN4-TAR

  5. HOW YOU CAN BE INVOLVED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journalvivo Low-Dose Low34 Revision 0 Approved for69HNUtHUl I IV1-30 IHOW

  6. Kinetics and dynamics of oxidation reactions involving adsorbed CO species on bulk supported Pt and copper oxides. Final project report, January 1, 1991--December 31, 1993

    SciTech Connect (OSTI)

    Conner, Wm.C.; Harold, M.

    1995-02-01

    This research was an integrated experimental and modeling study of oxidation reactions involving CO as a key player - be it a reactant, adsorbed intermediate, and/or partial oxidation product - in the catalytic sequence and chemistry. The reaction systems of interest in the project include CO, formaldehyde, and methanol oxidation by O{sub 2}, and CO oxidation by NO, on both Pt and copper oxide catalysts. These reactions are of importance in automobile exhaust catalysis. There is a paucity of rate data in the literature for these important environmental control reactions. A complicating factor is the propensity of these reactions to exhibit complex steady state and dynamic behavior, including multiple rate controlling steps, steady state multiplicity, and oscillatory phenomena. Such phenomena are rooted in some of the central issues of catalysis, including adsorbate interactions, and catalyst structural instabilities, such as surface reconstruction and surface chemical changes by oxidation- reduction. The goal of this research is to better understand the catalytic chemistry and kinetics of oxidations reactions involving CO as an adsorbed intermediate. Successfully meeting this goal requires an integration of basic kinetic measurements, in situ catalyst surface monitoring, kinetic modeling, and nonlinear mathematical tools. While the kinetics experiments have standard microreactor design, the potential for multiple and periodic rate states demands detailed procedures to pinpoint the bifurcation (ignition, extinction, Hopf) points. Kinetic models are constructed from rational mechanistic sequences and sound surface chemistry.

  7. Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation

    SciTech Connect (OSTI)

    Fu, Na; Su, Dian; Cort, John R.; Chen, Baowei; Xiong, Yijia; Qian, Weijun; Konopka, Allan; Bigelow, Diana J.; Squier, Thomas C.

    2013-03-06

    Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic pathways in response to changing environmental conditions. To enable in vivo measurements of cellular redox changes linked to disulfide bond formation, we have synthesized a cell-permeable monosubstituted cyanine dye derivatized with arsenic (i.e., TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins. Alkylation of reactive thiols prior to displacement of the bound TRAP-Cy3 by ethanedithiol permits facile protein capture and mass spectrometric identification of proximal reduced dithiols to the exclusion of individual cysteines. Applying TRAP_Cy3 to evaluate cellular responses to increases in oxygen and light levels in the photosynthetic microbe Synechococcus sp. PCC 7002, we observe large decreases in the abundance of reduced dithiols in cellular proteins, which suggest redox-dependent mechanisms involving the oxidation of proximal disulfides. Under these same growth conditions that result in the oxidation of proximal thiols, there is a reduction in the abundance of post-translational oxidative modifications involving nitrotyrosine and methionine sulfoxide formation. These results suggest that the redox status of proximal cysteines respond to environmental conditions, acting to regulate metabolic flux and minimize the formation of reactive oxygen species to decrease oxidative protein damage.

  8. 7/5/12 Higgs Boson Search Involving Texas A&M Physicists Reveals New Particle | Texas A&M University, Coll... 1/5www.science.tamu.edu/articles/911

    E-Print Network [OSTI]

    Toback, David

    7/5/12 Higgs Boson Search Involving Texas A&M Physicists Reveals New Particle | Texas A&M University, Coll... 1/5www.science.tamu.edu/articles/911 Home > News & Events Higgs Boson Search Involving for the Higgs boson, known as the "God particle" because it is thought to be responsible for generating mass

  9. Microenergetic research involving a coupled experimental and computational approach to evaluate microstructural effects on detonation and combustion at sub-millimeter geometries.

    SciTech Connect (OSTI)

    Nogan, John; Palmer, Jeremy Andrew; Brundage, Aaron L.; Long, Gregory T.; Wroblewski, Brian D.; Tappan, Alexander Smith; Renlund, Anita Mariana; Kravitz, Stanley H.; Baer, Melvin R.

    2006-07-01

    A new approach to explosive sample preparation is described in which microelectronics-related processing techniques are utilized. Fused silica and alumina substrates were prepared utilizing laser machining. Films of PETN were deposited into channels within the substrates by physical vapor deposition. Four distinct explosive behaviors were observed with high-speed framing photography by driving the films with a donor explosive. Initiation at hot spots was directly observed, followed by either energy dissipation leading to failure, or growth to a detonation. Unsteady behavior in velocity and structure was observed as reactive waves failed due to decreasing channel width. Mesoscale simulations were performed to assist in experiment development and understanding. We have demonstrated the ability to pattern these films of explosives and preliminary mesoscale simulations of arrays of voids showed effects dependent on void size and that detonation would not develop with voids below a certain size. Future work involves experimentation on deposited films with regular patterned porosity to elucidate mesoscale explosive behavior.

  10. Can biophysics tell us something about the weak equivalence principle vis a vis the thought experiment of Einstein involving human subjects?

    E-Print Network [OSTI]

    Fred H. Thaheld

    2009-06-16

    Over a period of several decades it has been noticed that most astronauts, either orbiting the earth or on trips to the moon, have observed phosphenes or light flashes (LF) including streaks, spots and clouds of light when their eyes are closed or they are in a darkened cabin. Scientists suspect that two separate components of cosmic rays cause these flashes due to direct interaction with the retina. This phenomenon is not noticed on the ground because of cosmic ray interaction with the atmosphere. The argument is advanced that this effect may provide us with a new method of exploring the weak equivalence principle from the standpoint of Einstein's original thought experiment involving human subjects. This can be done, utilizing the retina only, as an animate quantum mechanical measuring device or, in conjunction with the Anomalous Long Term Effects on Astronauts (ALTEA) facility.

  11. The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males

    SciTech Connect (OSTI)

    Zucchi, Sara [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gruendenstrasse 40, CH-4132 Muttenz (Switzerland); Bluethgen, Nancy [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gruendenstrasse 40, CH-4132 Muttenz (Switzerland); University of Basel, Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, CH-4056 Basel (Switzerland); Ieronimo, Andrea [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gruendenstrasse 40, CH-4132 Muttenz (Switzerland); Fent, Karl, E-mail: karl.fent@fhnw.ch [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gruendenstrasse 40, CH-4132 Muttenz (Switzerland); Swiss Federal Institute of Technology (ETHZ), Department of Environmental Sciences, CH-8092 Zuerich (Switzerland)

    2011-01-15

    Benzophenone-4 (BP-4) is frequently used as UV-absorber in cosmetics and materials protection. Despite its frequent detection in the aquatic environment potential effects on aquatic life are unknown. In this study, we evaluate the effects of BP-4 in eleuthero-embryos and in the liver, testis and brain of adult male fish on the transcriptional level by focusing on target genes involved in hormonal pathways to provide a more complete toxicological profile of this important UV-absorber. Eleuthero-embryos and males of zebrafish were exposed up to 3 days after hatching and for 14 days, respectively, to BP-4 concentrations between 30 and 3000 {mu}g/L. In eleuthero-embryos transcripts of vtg1, vtg3, esr1, esr2b, hsd17ss3, cyp19b cyp19a, hhex and pax8 were induced at 3000 {mu}g/L BP-4, which points to a low estrogenic activity and interference with early thyroid development, respectively. In adult males BP-4 displayed multiple effects on gene expression in different tissues. In the liver vtg1, vtg3, esr1 and esr2b were down-regulated, while in the brain, vtg1, vtg3 and cyp19b transcripts were up-regulated. In conclusion, the transcription profile revealed that BP-4 interferes with the expression of genes involved in hormonal pathways and steroidogenesis. The effects of BP-4 differ in life stages and adult tissues and point to an estrogenic activity in eleuthero-embryos and adult brain, and an antiestrogenic activity in the liver. The results indicate that BP-4 interferes with the sex hormone system of fish, which is important for the risk assessment of this UV-absorber.

  12. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

    SciTech Connect (OSTI)

    Hong, Wei, E-mail: hongwei@tijmu.edu.cn [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China) [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Li, Jinru; Wang, Bo [College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China)] [College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Chen, Linfeng [Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, 02115 MA (United States)] [Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, 02115 MA (United States); Niu, Wenyan; Yao, Zhi [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China)] [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); Baniahmad, Aria, E-mail: aban@mti.uni-jena.de [Institute for Human Genetics, Jena University Hospital, 07740 Jena (Germany)] [Institute for Human Genetics, Jena University Hospital, 07740 Jena (Germany)

    2011-12-02

    Highlights: Black-Right-Pointing-Pointer Corepressor Alien interacts with histone methyltransferase ESET in vivo. Black-Right-Pointing-Pointer Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TR{beta}1. Black-Right-Pointing-Pointer ESET-mediated H3K9 methylation is required for liganded TR{beta}1-repressed transcription. Black-Right-Pointing-Pointer ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by which Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TR{beta}1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TR{beta}1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TR{beta}1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TR{beta}1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.

  13. Low-Dose Involved-Field Radiation in the Treatment of Non-Hodgkin Lymphoma: Predictors of Response and Treatment Failure

    SciTech Connect (OSTI)

    Russo, Andrea L.; Chen, Yu-Hui; Martin, Neil E.; Vinjamoori, Anant; Luthy, Sarah K.; Freedman, Arnold; Michaelson, Evan M.; Silver, Barbara; Mauch, Peter M.; Ng, Andrea K.

    2013-05-01

    Purpose: To investigate clinical and pathologic factors significant in predicting local response and time to further treatment after low-dose involved-field radiation therapy (LD-IFRT) for non-Hodgkin lymphoma (NHL). Methods and Materials: Records of NHL patients treated at a single institution between April 2004 and September 2011 were retrospectively reviewed. Low-dose involved-field radiation therapy was given as 4 Gy in 2 fractions over 2 consecutive days. Treatment response and disease control were determined by radiographic studies and/or physical examination. A generalized estimating equation model was used to assess the effect of tumor and patient characteristics on disease response. A Cox proportional hazards regression model was used to assess time to further treatment. Results: We treated a total of 187 sites in 127 patients with LD-IFRT. Histologies included 66% follicular, 9% chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma, 10% marginal zone, 6% mantle cell lymphoma (MCL), and 8% other. Median follow-up time was 23.4 months (range, 0.03-92.2 months). The complete response, partial response, and overall response rates were 57%, 25%, and 82%, respectively. A CLL histology was associated with a lower response rate (odds ratio 0.2, 95% confidence interval 0.1-0.5, P=.02). Tumor size, site, age at diagnosis, and prior systemic therapy were not associated with response. The median time to first recurrence was 13.6 months. Those with CLL and age ?50 years at diagnosis had a shorter time to further treatment for local failures (hazard ratio [HR] 3.63, P=.01 and HR 5.50, P=.02, respectively). Those with CLL and MCL had a shorter time to further treatment for distant failures (HR 11.1 and 16.3, respectively, P<.0001). Conclusions: High local response rates were achieved with LD-IFRT across most histologies. Chronic lymphocytic leukemia and MCL histologies and age ?50 years at diagnosis had a shorter time to further treatment after LD-IFRT.

  14. Several Computer Science professors in the Department of Computing & Information Technology at The University of the West Indies, are involved in a 3-year project of infusing ICT into Agriculture in

    E-Print Network [OSTI]

    Stanley, Kenneth O.

    at The University of the West Indies, are involved in a 3-year project of infusing ICT into Agriculture in Trinidad. Bernard is the lead on the AgriNeTT project, a multidisciplinary project which focuses on infusing ICT

  15. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor ?E is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by ?E in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition ?E regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmoreSalmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by ?E in at least one of the three conditions. An important finding is that ?E up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, ?E is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between ?E and SPI-2 genes, combined with the global regulatory effect of ?E, may account for the lethality of rpoE-deficient Salmonella in murine infection.less

  16. Tap and Dbp5, but not Gag, are involved in DR-mediated nuclear export of unspliced Rous sarcoma virus RNA

    SciTech Connect (OSTI)

    LeBlanc, Jason J. [Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Uddowla, Sabena [Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Abraham, Benjamin [Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Clatterbuck, Sarah [Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Beemon, Karen L. [Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States)]. E-mail: KLB@jhu.edu

    2007-07-05

    All retroviruses must circumvent cellular restrictions on the export of unspliced RNAs from the nucleus. While the unspliced RNA export pathways for HIV and Mason-Pfizer monkey virus are well characterized, that of Rous sarcoma virus (RSV) is not. We have previously reported that the RSV direct repeat (DR) elements are involved in the cytoplasmic accumulation of unspliced viral RNA. Here, using fluorescent in situ hybridization (FISH), we demonstrate that unspliced viral RNAs bearing a single point mutation (G8863C) in the DR exhibit a restricted cellular localization in and around the nucleus. In contrast, wild type unspliced viral RNA had a diffuse localization throughout the nucleus and cytoplasm. Since the RSV Gag protein has a transient localization in the nucleus, we examined the effect of Gag over-expression on a DR-mediated reporter construct. While Gag did not enhance DR-mediated nuclear export, the dominant-negative expression of two cellular export factors, Tap and Dbp5, inhibited expression of the same reporter construct. Furthermore, FISH studies using the dominant-negative Dbp5 demonstrated that unspliced wild type RSV RNA was retained within the nucleus. Taken together, these results further implicate the DR in nuclear RNA export through interactions with Tap and Dbp5.

  17. The Fas-associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in TNF-induced activation of ERK

    SciTech Connect (OSTI)

    Lueschen, Silke [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Falk, Markus [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Scherer, Gudrun [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Ussat, Sandra [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Paulsen, Maren [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany); Adam-Klages, Sabine [Institut fuer Immunologie, Universitaetsklinikum Schleswig-Holstein Campus Kiel, Michaelisstrasse 5, 24105 Kiel (Germany)]. E-mail: sadam@email.uni-kiel.de

    2005-10-15

    The cytokine TNF activates multiple signaling pathways leading to cellular responses ranging from proliferation and survival to apoptosis. While most of these pathways have been elucidated in detail over the past few years, the molecular mechanism leading to the activation of the MAP kinases ERK remains ill defined and is controversially discussed. Therefore, we have analyzed TNF-induced ERK activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner. In addition, we provide evidence for the involvement of the signaling components Fas-associated death domain protein (FADD), caspase-8, and c-FLIP in the pathway activating ERK in response to TNF. This conclusion is based on the following observations: (I) Overexpression of FADD, caspase-8, or a c-FLIP protein containing the death effector domains only leads to enhanced and prolonged ERK activation after TNF treatment. (II) TNF-induced ERK activation is strongly diminished in the absence of FADD. Interestingly, the enzymatic function of caspase-8 is not required for TNF-induced ERK activation. Additional evidence suggests a role for this pathway in the proliferative response of murine fibroblasts to TNF.

  18. Thermal and combined thermal and radiolytic reactions involving nitrous oxide, hydrogen, nitrogen, and ammonia in contact with tank 241-SY-101 simulated waste

    SciTech Connect (OSTI)

    Bryan, S.A.; Pederson, L.R.

    1996-02-01

    Work described in this report was conducted at Pacific Northwest National Laboratory (PNNL) for the Flammable Gas Safety Project, the purpose of which is to develop information needed to support Westinghouse Hanford Company (WHC) in their efforts to ensure the safe interim storage of wastes at the Hanford Site. Described in this report are the results of tests to evaluate the rates of thermal and combined thermal and radiolytic reactions involving flammable gases in the presence of Tank 241-SY-101 simulated waste. Flammable gases generated by the radiolysis of water and by the thermal and radiolytic decomposition of organic waste constituents may themselves participate in further reactions. Examples include the decomposition of nitrous oxide to yield nitrogen and oxygen, the reaction of nitrous oxide and hydrogen to produce nitrogen and water, and the reaction of nitrogen and hydrogen to produce ammonia. The composition of the gases trapped in bubbles in the wastes might therefore change continuously as a function of the time that the gas bubbles are retained.

  19. Theory of ultra dense matter and the dynamics of high energy interactions involving nuclei. Progress report, December 15, 1993--December 14, 1994

    SciTech Connect (OSTI)

    Gyulassy, M.

    1994-09-12

    This report summarizes the progress made during the second year of the three year DOE agreement DE-FG02-93ER40764 on theoretical nuclear physics research performed at the Columbia University and presents a detailed budget adjustment for the third year period December 15, 1994 to December 14, 1995. Sections 1.1 to 1.8 highlight the technical progress made on the following general areas: Multiple scattering and radiative processes in QCD; the quark-gluon plasma transition in nuclear matter; QCD transport theory and dissipative mechanism in dense matter; phenomenological models of high energy interactions involving nuclei; signatures of quark-gluon plasma formation in A+A; neurocomputation theory. Section 2 contains a bibliography of published papers and invited conference papers. Section 3 lists the Columbia nuclear theory members for the December 15, 1994 to December 14, 1995 period. Finally, the budget adjustment requesting $319,830 for the third year relative to the original $320,000 is presented in section 6. Copies of the research papers accompany this report.

  20. GABA/sub B/ receptor activation inhibits Ca/sup 2 +/-activated potassium channels in synaptosomes: involvement of G-proteins

    SciTech Connect (OSTI)

    Ticku, M.K.; Delgado, A.

    1989-01-01

    /sup 86/Rb-efflux assay from preloaded synaptosomes of rat cerebral cortex was developed to study the effect of GABA/sub B/ receptor agonist baclofen on Ca/sup 2 +/-activated K/sup +/-channels. Depolarization of /sup 86/Rb-loaded synaptosomes in physiological buffer increased Ca/sup 2 +/-activated /sup 86/Rb-efflux by 400%. The /sup 86/Rb-efflux was blocked by quinine sulfate, tetraethylammonium, and La/sup 3 +/ indicating the involvement of Ca/sup 2 +/-activated K/sup +/-channels. (-)Baclofen inhibited Ca/sup 2 +/-activated /sup 86/Rb-efflux in a stereospecific manner. The inhibitory effect of (-)baclofen was mediated by GABA/sub B/ receptor activation, since it was blocked by GABA/sub B/ antagonist phaclofen, but not by bicuculline. Further, pertussis toxin also blocked the ability of baclofen or depolarizing action to affect Ca/sup 2 +/-activated K/sup +/-channels. These results suggest that baclofen inhibits Ca/sup 2 +/-activated K/sup +/-channels in synaptosomes and these channels are regulated by G-proteins. This assay may provide an ideal in vitro model to study GABA/sub B/ receptor pharmacology.

  1. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in ?E-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor ?E is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by ?E in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition ?E regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmoreSalmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by ?E in at least one of the three conditions. An important finding is that ?E up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, ?E is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between ?E and SPI-2 genes, combined with the global regulatory effect of ?E, may account for the lethality of rpoE-deficient Salmonella in murine infection.less

  2. t(8; 14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region

    SciTech Connect (OSTI)

    Haluska, F.G.; Tsujimoto, Y.; Croce, C.M.

    1987-10-01

    Recent molecular analyses of Burkitt lymphomas carrying the t(8;14) chromosome translocation have indicated that a dichotomy exists regarding the molecular mechanisms by which the translocations occur. Most sporadic Burkitt tumors carry translocations that apparently arise due to mistakes in the immunoglobulin isotype-switching process. In contrast, there is evidence that the translocations of most endemic Burkitt lymphomas occur as a consequence of aberrant V-D-J recombination of variable, diversity, and joining gene segments, catalyzed by the recombinase enzymes. This phenomenon was first noted in follicular lymphomas and chronic lymphocytic leukemias of the B-cell lineage and has been described in T-cell malignancies as well. In each of these cases, analysis of the nucleotide sequence at chromosome breakpoints demonstrated the involvement of immunoglobulin heavy chain J/sub H/ or T-cell-receptor ..cap alpha..-chain J..cap alpha.. gene segments in the translocation. The authors now have cloned and sequenced both the 8q- and 14q+ translocation breakpoints deriving from the t(8;14) translocation of the endemic Burkitt lymphoma line Daudi. The data show that the translocation resulted from a reciprocal exchange between the D/sub H/ region on chromosome 14 and sequences far 5' of the MYC protooncogene on chromosome 8. Features of the nucleotide sequences surrounding the breakpoint further implicate the V-D-J joining machinery in the genesis of chromosome translocation in endemic Burkitt lymphomas and, more generally, in other lymphoid malignancies as well.

  3. Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2

    SciTech Connect (OSTI)

    Kalayarasan, Srinivasan, E-mail: kalaivasanbio@gmail.com; Sriram, Narayanan; Soumyakrishnan, Syamala; Sudhandiran, Ganapasam, E-mail: sudhandiran@yahoo.com

    2013-09-01

    Pulmonary fibrosis (PF) can be a devastating lung disease. It is primarily caused by inflammation leading to severe damage of the alveolar epithelial cells. The pathophysiology of PF is not yet been clearly defined, but studying lung parenchymal injury by involving reactive oxygen species (ROS) through the activation of protease activated receptor-2 (PAR-2) may provide promising results. PAR-2 is a G-protein coupled receptor is known to play an important role in the development of PF. In this study, we investigated the inhibitory role of diallylsulfide (DAS) against ROS mediated activation of PAR-2 and collagen production accompanied by epithelial cell apoptosis. Bleomycin induced ROS levels may prompt to induce the expression of PAR-2 as well as extracellular matrix proteins (ECM), such as MMP 2 and 9, collagen specific proteins HSP-47, ?-SMA, and cytokines IL-6, and IL-8RA. Importantly DAS treatment effectively decreased the expression of all these proteins. The inhibitory effect of DAS on profibrotic molecules is mediated by blocking the ROS level. To identify apoptotic signaling as a mediator of PF induction, we performed apoptotic protein expression, DNA fragmentation analysis and ultrastructural details of the lung tissue were performed. DAS treatment restored all these changes to near normalcy. In conclusion, treatment of PF bearing rats with DAS results in amelioration of the ROS production, PAR-2 activation, ECM production, collagen synthesis and alveolar epithelial cell apoptosis during bleomycin induction. We attained the first evidence that treatment of DAS decreases the ROS levels and may provide a potential therapeutic effect attenuating bleomycin induced PF. - Highlights: DAS inhibits PAR-2 activity; bleomycin stimulates PAR-2 activity. Increase in PAR-2 activity is correlated with pulmonary fibrosis DAS reduces pro-inflammatory activity linked to facilitating pulmonary fibrosis. DAS inhibits apoptosis of alveolar epithelial cells.

  4. The accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Li, Yuan [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Li, Huiqiao [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China)] [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China); Pang, Ying; Zhao, Yue; Jiang, Rongrong; Shen, Lu [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Zhou, Jianwei; Wang, Xinru [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)] [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Liu, Qizhan, E-mail: drqzliu@hotmail.com [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)

    2013-01-15

    The biphasic effects of arsenite, in which low levels of arsenite induce cell proliferation and high levels of arsenite induce DNA damage and apoptosis, apparently contribute to arsenite-induced carcinogenesis. However, the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the effects of different levels of arsenite on cell proliferation, DNA damage and apoptosis as well as on signal transduction pathways in human bronchial epithelial (HBE) cells. Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2? (HIF-2?) in HBE cells. ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2?. In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1? degradation. Down-regulation of HIF-1? by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite. Thus, data in the present study suggest that the accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. -- Highlights: ? Biphasic effects induced by different concentrations of arsenite. ? Different regulation of ERK or JNK signal pathway by arsenite. ? Different regulation of HIF1? or HIF 2? by arsenite.

  5. MAPK/ERK and Wnt/{beta}-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells

    SciTech Connect (OSTI)

    Jin, Caixia [Department of Surgery, University of North Carolina at Chapel Hill (United States) [Department of Surgery, University of North Carolina at Chapel Hill (United States); Department of Medical Genetics and Cell Biology, Ningxia Medical University, Yinchuan 750004 (China); Samuelson, Lisa; Cui, Cai-Bin; Sun, Yangzhong [Department of Surgery, University of North Carolina at Chapel Hill (United States)] [Department of Surgery, University of North Carolina at Chapel Hill (United States); Gerber, David A., E-mail: david_gerber@med.unc.edu [Department of Surgery, University of North Carolina at Chapel Hill (United States); Lineberger Cancer Center, University of North Carolina at Chapel Hill (United States)

    2011-06-17

    Highlights: {yields} Activation of MAPK/ERK pathway with epidermal growth factor (EGF) significantly increased Sca-1{sup +} HPC proliferation and colony formation. {yields} Activation of either IL-6/STAT3 or Wnt/{beta}-Catenin pathway did not independently support cell proliferation and colony formation of HPCs. {yields} Wnt/{beta}-Catenin pathway can cooperate with EGF to significantly promote HPC colony formation and maintain long-term HPCs in vitro. -- Abstract: Hepatic progenitor cells (HPCs) persist in adulthood and have the potential to play a major role in regenerating diseased liver. However, the signaling pathways that both directly and indirectly regulate HPCs' self-renewal and differentiation remain elusive. Previously, we identified a bipotent, stem cell antigen-1 (Sca-1) positive HPC population from naive adult liver tissue. In the present study, we aimed to investigate the involvement of various signaling pathways in Sca-1{sup +} HPC proliferation. Epidermal growth factor (EGF) supplementation shows a significant increase in Sca-1{sup +} HPC proliferation and colony formation while stimulating phosphorylation of ERK1/2 and activating the induction of Cyclin D1. There were no demonstrable effects of EGF on Akt. The MEK inhibitor, PD0325901, inhibits proliferation and ERK1/2 phosphorylation while also suppressing the expression of Cyclin D1. In addition, activation of either IL-6/STAT3 or Wnt/{beta}-Catenin pathway did not independently support cell proliferation and colony formation of HPCs. The Wnt/{beta}-Catenin pathway can cooperate with EGF to significantly promote HPC colony formation ratio and maintain long-term HPC in vitro. The data indicates that the MAPK/ERK pathway is both essential and critical for HPC proliferation, and the Wnt signaling pathway is not sufficient, while it works synergistically with the MAPK/ERK signaling pathway to promote HPC proliferation.

  6. Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB{sub 1} receptors and apoptotic cell death

    SciTech Connect (OSTI)

    Tomiyama, Ken-ichi; Funada, Masahiko

    2014-01-01

    The abuse of herbal products containing synthetic cannabinoids has become an issue of public concern. The purpose of this paper was to evaluate the acute cytotoxicity of synthetic cannabinoids on mouse brain neuronal cells. Cytotoxicity induced by synthetic cannabinoid (CP-55,940, CP-47,497, CP-47,497-C8, HU-210, JWH-018, JWH-210, AM-2201, and MAM-2201) was examined using forebrain neuronal cultures. These synthetic cannabinoids induced cytotoxicity in the forebrain cultures in a concentration-dependent manner. The cytotoxicity was suppressed by preincubation with the selective CB{sub 1} receptor antagonist AM251, but not with the selective CB{sub 2} receptor antagonist AM630. Furthermore, annexin-V-positive cells were found among the treated forebrain cells. Synthetic cannabinoid treatment induced the activation of caspase-3, and preincubation with a caspase-3 inhibitor significantly suppressed the cytotoxicity. These synthetic cannabinoids induced apoptosis through a caspase-3-dependent mechanism in the forebrain cultures. Our results indicate that the cytotoxicity of synthetic cannabinoids towards primary neuronal cells is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and further suggest that caspase cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. In conclusion, excessive synthetic cannabinoid abuse may present a serious acute health concern due to neuronal damage or deficits in the brain. - Highlights: Synthetic cannabinoids (classical cannabinoids, non-classical cannabinoids, and aminoalkylindole derivatives) induce cytotoxicity in mouse forebrain cultures. Synthetic cannabinoid-induced cytotoxicity towards forebrain cultures is mediated by the CB{sub 1} receptor, but not by the CB{sub 2} receptor, and involves caspase-dependent apoptosis. A high concentration of synthetic cannabinoids may be toxic to neuronal cells that express CB{sub 1} receptors.

  7. Breast Cancer Patients With 10 or More Involved Axillary Lymph Nodes Treated by Multimodality Therapy: Influence of Clinical Presentation on Outcome

    SciTech Connect (OSTI)

    Geara, Fady B. . E-mail: fg00@aub.edu.lb; Nasr, Elie; Tucker, Susan L.; Charafeddine, Maya; Dabaja, Bouthaina; Eid, Toufic; Abbas, Jaber; Salem, Ziad; Shamseddine, Ali; Issa, Philip; El Saghir, Nagi

    2007-06-01

    Purpose: To analyze tumor control and survival for breast cancer patients with 10 or more positive lymph nodes without systemic disease, treated by adjuvant radiation alone or combined-modality therapy. Methods and Materials: We reviewed the records of 309 consecutive patients with these characteristics who received locoregional radiotherapy (RT) at our institution. The majority of patients had clinical Stage II or IIIA-B disease (43% and 48%, respectively). The median number of positive axillary lymph nodes was 15 (range, 10-78). Adjuvant therapy consisted of RT alone, with or without chemotherapy, tamoxifen, and/or ovarian castration. Results: The overall 5-year and 10-year disease-free survival (DFS) rates were 20% and 7%, respectively. Median DFS was higher for patients with Stage I-II compared with those with Stage IIIABC (28 vs. 19 months; p = 0.006). Median DFS for patients aged {<=}35 years was lower than that of older patients (12 vs. 24 months; p < 0.0001). Patients treated with a combination therapy had a higher 5-year DFS rate compared with those treated by RT alone (26% vs. 11%; p 0.03). In multivariate analysis, clinical stage (III vs. I, II; relative risk = 1.8, p = 0.002) and age ({<=}35 vs. others; relative risk = 2.6, p <0.001) were found to be independent variables for DFS. Conclusion: This retrospective data analysis identified young age and advanced clinical stage as pertinent and independent clinical prognostic factors for breast cancer patients with advanced axillary disease (10 or more involved nodes). These factors can be used for further prognostic classification.

  8. Epithelialmesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells

    SciTech Connect (OSTI)

    Ding, Song-Ze; Yang, Yu-Xiu; Li, Xiu-Ling; Michelli-Rivera, Audrey; Han, Shuang-Yin; Wang, Lei; Pratheeshkumar, Poyil; Wang, Xin; Lu, Jian; Yin, Yuan-Qin; Budhraja, Amit; Hitron, Andrew J.

    2013-05-15

    Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Exposure to Cr(VI) induces DNA damage, cell morphological change and malignant transformation in human lung epithelial cells. Despite extensive studies, the molecular mechanisms remain elusive, it is also not known if Cr(VI)-induced transformation might accompany with invasive properties to facilitate metastasis. We aimed to study Cr(VI)-induced epithelialmesenchymal transition (EMT) and invasion during oncogenic transformation in lung epithelial cells. The results showed that Cr(VI) at low doses represses E-cadherin mRNA and protein expression, enhances mesenchymal marker vimentin expression and transforms the epithelial cell into fibroblastoid morphology. Cr(VI) also increases cell invasion and promotes colony formation. Further studies indicated that Cr(VI) uses multiple mechanisms to repress E-cadherin expression, including activation of E-cadherin repressors such as Slug, ZEB1, KLF8 and enhancement the binding of HDAC1 in E-cadherin gene promoter, but DNA methylation is not responsible for the loss of E-cadherin. Catalase reduces Cr(VI)-induced E-cadherin and vimentin protein expression, attenuates cell invasion in matrigel and colony formation on soft agar. These results demonstrate that exposure to a common human carcinogen, Cr(VI), induces EMT and invasion during oncogenic transformation in lung epithelial cells and implicate in cancer metastasis and prevention. - Graphical abstract: Epithelialmesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanisms in lung epithelial cells. - Highlights: We study if Cr(VI) might induce EMT and invasion in epithelial cells. Cr(VI) induces EMT by altering E-cadherin and vimentin expression. It also increases cell invasion and promotes oncogenic transformation. Catalase reduces Cr(VI)-induced EMT, invasion and transformation.

  9. SU-E-T-587: Monte Carlo Versus Ray-Tracing for Treatment Planning Involving CNS Tumors On the MultiPlan System for CyberKnife Radiosurgery

    SciTech Connect (OSTI)

    Forbang, R Teboh

    2014-06-01

    Purpose: MultiPlan, the treatment planning system for the CyberKnife Robotic Radiosurgery system offers two approaches to dose computation, namely Ray-Tracing (RT), the default technique and Monte Carlo (MC), an option. RT is deterministic, however it accounts for primary heterogeneity only. MC on the other hand has an uncertainty associated with the calculation results. The advantage is that in addition, it accounts for heterogeneity effects on the scattered dose. Not all sites will benefit from MC. The goal of this work was to focus on central nervous system (CNS) tumors and compare dosimetrically, treatment plans computed with RT versus MC. Methods: Treatment plans were computed using both RT and MC for sites covering (a) the brain (b) C-spine (c) upper T-spine (d) lower T-spine (e) L-spine and (f) sacrum. RT was first used to compute clinically valid treatment plans. Then the same treatment parameters, monitor units, beam weights, etc., were used in the MC algorithm to compute the dose distribution. The plans were then compared for tumor coverage to illustrate the difference if any. All MC calculations were performed at a 1% uncertainty. Results: Using the RT technique, the tumor coverage for the brain, C-spine (C3C7), upper T-spine (T4T6), lower T-spine (T10), Lspine (L2) and sacrum were 96.8%, 93.1%, 97.2%, 87.3%, 91.1%, and 95.3%. The corresponding tumor coverage based on the MC approach was 98.2%, 95.3%, 87.55%, 88.2%, 92.5%, and 95.3%. It should be noted that the acceptable planning target coverage for our clinical practice is >95%. The coverage can be compromised for spine tumors to spare normal tissues such as the spinal cord. Conclusion: For treatment planning involving the CNS, RT and MC appear to be similar for most sites but for the T-spine area where most of the beams traverse lung tissue. In this case, MC is highly recommended.

  10. Properties of Josephson junctions involving the cos(kx)cos(ky) pairing state in iron pnictides Wei-Feng Tsai,1 Dao-Xin Yao,1 B. Andrei Bernevig,2 and JiangPing Hu1

    E-Print Network [OSTI]

    Hu, Jiangping

    Properties of Josephson junctions involving the cos(kx)·cos(ky) pairing state in iron pnictides Wei; published 30 July 2009 We propose a trilayer -junction that takes advantage of the unconventional sx2y2 =cos kx cos ky pairing symmetry which changes sign between electron and hole Fermi pockets in the iron

  11. Access Provided by The University Of Texas at Austin, General Libraries at 07/04/11 11:06PM GMT LIBRARY TRENDS, Vol. 59, No. 4, 2011 ("Involving Users in the Co-Construction of Digital

    E-Print Network [OSTI]

    Feinberg, Melanie

    ;LIBRARY TRENDS, Vol. 59, No. 4, 2011 ("Involving Users in the Co-Construction of Digital KnowledgeAccess Provided by The University Of Texas at Austin, General Libraries at 07/04/11 11:06PM GMT #12 in Libraries, Archives, and Museums," edited by Paul F. Marty and Michelle M. Kazmer), pp. 588606. 2011

  12. Chemical Engineering students learn to solve practical problems that in one way or another involve chemistry --including biochemistry --as well as the composition or structure of materials. They are specifically concerned with the principles and processes

    E-Print Network [OSTI]

    Bustamante, Fabin E.

    Chemical Engineering students learn to solve practical problems that in one way or another involve to modern civilization. Chemical engineering also plays a major role in developing methods for protecting Grads Analyst, Exxon Mobile System Integration Analyst, Accenture Production Engineer, Dow Chemical

  13. The role of the school social worker in family involvement as identified by family specialists and parents in selected title I schools in North East Independent School District in San Antonio, Texas

    E-Print Network [OSTI]

    Canada, Gloria Lou

    2009-05-15

    that the variables of open communication between home and school and the school being inviting to parents are positive factors in iv getting parents involved. Research Question 3 asked, ?What influence do community agencies have in assisting with the needs... .......................................................................... 66 viii TABLE Page 10. Number of Respondents and Percentage of Responses of Parent and Number of Respondents and Percentage of Responses of Family Specialists Identifying Degree to Which School Is Welcoming and Inviting to Parents...

  14. SMR Handbook: Hybrid Energy Systems Involving SMRs

    SciTech Connect (OSTI)

    Shannon M. Bragg-Sitton

    2014-09-01

    Large-scale nuclear reactors are traditionally operated for a singular purpose: steady-state production of dispatchable baseload electricity that is distributed broadly on the electric grid. While this implementation is key to a sustainable, reliable energy grid, SMRs offer new opportunities for increased use of clean nuclear energy for both electric and thermal applications in more locations while still accommodating the desire to support renewable production sources. This chapter considers a scenario in which renewable generation would be tightly coupled with the nuclear generation source behind the grid to meet the grid demand as an integrated energy system while simultaneously producing other commodities with the available thermal energy.

  15. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  16. Involvement of peptides in nitrogen fixation

    E-Print Network [OSTI]

    Ahlgren, Joy Annette

    1983-01-01

    molecular weight. 4 Effect of fixed nitrogen (Ca(NO&)z) on the nodula- tion (the number of nodules per plant), growth of nodules (mg per nodule), nitrogenase activity (acetylene reduction assay), and soyrhizin A con- tent in arginine equivalents. 22... solution and 0. 2 g of picric acid were mixed, the volume reduced to 10 approximately 20 ml by vacuum evaporation, and then centrifuged at 25, 000g for 20 min. Each of these samples was eluted from a column of 10 0 go e AG 248 e 1 . F o Rhitohiom 2~4 tc...

  17. Fukushima Media Involvement: Lessons Learned and Challenges

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Koller, Greg L.; Johnson, Wayne L.

    2013-04-01

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the Department of Energys Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Within days, PNNL had set up a technical team in support of the U.S. governments efforts to assist the devastated country. While a vast amount of information began to flow from Japan, the situation rapidly evolved challenging PNNL scientists and engineers, as well as news media and the general public to deal with a complex and often conflicting information stream. Over the course of about three weeks, PNNLs News & Media Relations staff and its scientists and engineers responded to more than one hundred requests for information, and engaged in dozens of personal interviews with international, national, regional and local media. While many of the interviews and resulting stories were accurate and well done, to say that all communication went flawless would be far from the truth. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Even when communications guidelines are established and agreed-to ahead of time, and spokespeople promise to stay on message and within their areas of expertise, there is no guarantee the ball will not be dropped on occasion. Addressed here is the rest of the story.

  18. involvement Patients Participate! was a collaborative project

    E-Print Network [OSTI]

    Rzepa, Henry S.

    government. The British Library is the UK's national library. We provide access to the world's most UKOLN, based at the University of Bath, the British Library and the Association of Medical Research and the public in deciding what research to fund. This is what the charity Asthma UK says about the role of lay

  19. Factors Involved in Search Dog Training

    E-Print Network [OSTI]

    Alexander, Michael B.

    2010-07-14

    Events of significant impact as recent as hurricane Ike yielded a consistent disturbing truth: we lack sufficient numbers of competent search dog [Canis familiaris] teams. This study was conceived to provide information in identifying factors...

  20. DEPARTMENTS INVOLVED WITH WEED RESEARCH AND EDUCATION

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    for yellow toadflax biocontrol, David Weaver Identifying and testing candidate agents for Russian olive to suppress spotted knapweed? Jeff Mosley Determining the efficacy of biocontrol using Mecinus janthinus biocontrol, David Weaver Memorize, recognize, prioritize: Noxious weed education action program, Jane

  1. DEPARTMENTS INVOLVED WITH WEED RESEARCH AND EDUCATION

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    for Producers, Bill Dyer Identifying and Testing Candidate Agents for Russian Olive Biocontrol, David Weaver Mosley Continental Divide Barrier Zone, Kim Goodwin Determining the Efficacy of Biocontrol Using and Monitoring Insectaries for Yellow Toadflax Biocontrol, David Weaver Herbicide Resistance Extension Info

  2. Exploring the Future Development in Employee Involvement

    E-Print Network [OSTI]

    Al Hanbali, Ahmad

    and decentralized. Via the Delphi method consensus was achieved. Two rounds, first qualitative then quantitative prior specific permission and/or a fee. 5th IBA Bachelor Thesis Conference, July 2nd , 2015, Enschede

  3. Cooperative involvement and opportunities in oilseeds

    SciTech Connect (OSTI)

    Dunn, J.R.; Reynolds, B.J.; Eversull, E.E.; Skinner, R.A.; Thurston, S.K.

    1982-01-01

    This report focuses on the opportunities for US cooperatives to improve their position in the oilseeds complex as they face increasing vertical integration and restructuring by large, competing noncooperative firms. Cooperatives operated 38 oilseed processing plants, 19 of them soybean plants, 17 cottonseed plants, 1 peanut plant, and 1 sunflower/flaxseed plant. Total cooperative soybean crushing capacity was 280 million bushels in 1979-1980, representing a 20.7% share of US crushing capacity and an 8.2% share of world crushing capacity. Cooperative soybean crushing capacity increased by 75% during the 1970's. The four largest soybean processing firms in terms of crushing capacity operated 54.5% of total US capacity. The top eight firms operated 75.1%, and the top 20 firms operated 96.4%. Eight of the top 20 soybean processing firms are cooperatives. Cooperatives operated 17 of the 78 cottonseed mills active in 1979. These mills had a total capacity of 6690 tons per day for a 35% share of total US cottonseed crushing capacity. 28 references, 11 figures, 44 tables.

  4. Central Plateau Principles Public Involvement Advice DETAILED...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    either 99% or 99.9% of waste from the tanks. USDOE's TCWMEIS analysis shows that the cancer risk from drinking well water miles away (at the Core Zone Boundary) would greatly...

  5. Faculty Involved with the Alternative Energy Minor

    E-Print Network [OSTI]

    occurring in the area of hydrogen fuel cells, biofuels, and solar cells. Such technologies have been3131 Instrumentation (3) Energy Technologies Courses (Select 4-6 credits): _____ CM/ENT 3974 Fuel Cell Fundamentals (1) OR _____ MEEM4260 Fuel Cell Technology (3) _____ EC 4620 Energy Economics (3)* _____ EE 3120

  6. Community Involvement and Making a Difference

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit the following comments responseScience SHERWOODAMF/GNDRAD

  7. Mound Site Community Involvement Plan 2012

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouthReport for the Weldon Spring, Missouri,MSEReportyGWSHPInvolvement

  8. RAPID/Get Involved | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onRAPID/Geothermal/Exploration/Colorado <RAPID/Geothermal/Water Use/Nevada <Utah < RAPID‎ | Geothermal‎

  9. Community Involvement | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAuditsCluster Compatibilitydefault Sign InSeptember 2015Community Giving

  10. Sandia National Laboratories: About Sandia: Community Involvement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid youOxygenLaboratoryInnovation Portal SNL Site Map

  11. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid youOxygenLaboratoryInnovation Portal SNL Site MapContribution

  12. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid youOxygenLaboratoryInnovation Portal SNL Site

  13. Sandia National Laboratories: Community Involvement: Volunteer Programs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid youOxygenLaboratoryInnovation PortalHiringCareers StudentsCommunity

  14. A Good Neighbor: Community Involvement | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.TheoryTuesday, August 10, 20102016 News Below are4BElectron---neutrinoAAA G E NA Good

  15. Strategic Public Involvement Products For Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3 PreparedcordiallyGlobal Demand

  16. Strategic Public Involvement … Tool Time!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3 PreparedcordiallyGlobal DemandLiz Mattson,

  17. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of

  18. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 2012 FINAL

  19. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 2012 FINALJune

  20. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 2012

  1. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 201211, 2011

  2. Public Involvement and Communications Committee Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 201211,

  3. Public Involvement and Communications Committee - Transcribed Flipcharts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeedingProgramExemptionsProtein Dynamics HitPseudogapBenefits of8, 201211,Page 1

  4. Department of Energy Idaho - Public Involvement Opportunity

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you not find what you were looking for?DelegationsInsideand VideoPublic

  5. UT gets involved at Oak Ridge

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With WIPPfinal design andBiofuels for MilitaryUSRussianLetter.pdfUT

  6. FOIASI - Special Inquiry Review of Allegations Involving

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12, 2015Executive Order14, 2011 CX-006821:forEnergy 39

  7. Public Involvement Plan | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested PartiesBuildingBudget || Department ofDepartment ofNuclear Damage2002Public

  8. Community Involvement Fund | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergy Webinar:I DueBETOoffor useDevelopmentDepartmentCommunityCommunity

  9. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation Portal SandiaAnalysisEducation Programs:

  10. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation Portal SandiaAnalysisEducation

  11. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation Portal SandiaAnalysisEducationEducation

  12. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation Portal

  13. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation PortalEducation Programs: Science,

  14. Sandia National Laboratories: About Sandia: Community Involvement:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovation PortalEducation Programs: Science,Education

  15. Study on proliferative responses to host Ia antigens in allogeneic bone marrow chimera in mice: sequential analysis of the reactivity and characterization of the cells involved in the responses

    SciTech Connect (OSTI)

    Iwabuchi, K.; Ogasawara, K.; Ogasawara, M.; Yasumizu, R.; Noguchi, M.; Geng, L.; Fujita, M.; Good, R.A.; Onoe, K.

    1987-01-01

    Irradiation bone marrow chimeras were established by reconstitution of lethally irradiated AKR mice with C57BL/10 marrow cells to permit serial analysis of the developing reactivities of lymphocytes from such chimeras, (B10----AKR), against donor, host, or third party antigens. We found that substantial proliferative responses to Ia antigens of the recipient strain and also to third party antigens were generated by the thymocytes obtained from the irradiation chimeras at an early stage after bone marrow reconstitution. The majority of the responding thymocytes had surfaces lacking demonstrable peanut agglutinin receptors and were donor type Thy-1+, Ly-2-, and L3T4+ in both anti-recipient and anti-third party MLR. In anti-host responses, however, Ly-2+ thymocytes seemed to be at least partially involved. This capacity of thymus cells to mount a response to antigens of the recipient strain declined shortly thereafter, whereas the capacity to mount MLR against third party antigens persisted. The spleen cells of (B10----AKR) chimeras at the same time developed a more durable capability to exhibit anti-host reactivities and a permanent capability of reacting to third party allo-antigens. The stimulator antigens were Ia molecules on the stimulator cells in both anti-recipient and anti-third party MLR. The responding splenocytes were of donor origin and most of them had Thy-1+, Ly-1+2-, and L3T4+ phenotype.

  16. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  17. Definite Integrals, Some Involving Residue Theory Evaluated by Maple Code

    SciTech Connect (OSTI)

    Bowman, Kimiko o [ORNL

    2010-01-01

    The calculus of residue is applied to evaluate certain integrals in the range (-{infinity} to {infinity}) using the Maple symbolic code. These integrals are of the form {integral}{sub -{infinity}}{sup {infinity}} cos(x)/[(x{sup 2} + a{sup 2})(x{sup 2} + b{sup 2}) (x{sup 2} + c{sup 2})]dx and similar extensions. The Maple code is also applied to expressions in maximum likelihood estimator moments when sampling from the negative binomial distribution. In general the Maple code approach to the integrals gives correct answers to specified decimal places, but the symbolic result may be extremely long and complex.

  18. Kinetics and mechanisms of reactions involving small aromatic reactive intermediates

    SciTech Connect (OSTI)

    Lin, M.C. [Emory Univ., Atlanta, GA (United States)

    1993-12-01

    Small aromatic radicals such as C{sub 6}H{sub 5}, C{sub 6}H{sub 5}O and C{sub 6}H{sub 4} are key prototype species of their homologs. C{sub 6}H{sub 5} and its oxidation product, C{sub 6}H{sub 5}O are believed to be important intermediates which play a pivotal role in hydrocarbon combustion, particularly with regard to soot formation. Despite their fundamental importance, experimental data on the reaction mechanisms and reactivities of these species are very limited. For C{sub 6}H{sub 5}, most kinetic data except its reactions with NO and NO{sub 2}, were obtained by relative rate measurements. For C{sub 6}H{sub 5}O, the authors have earlier measured its fragmentation reaction producing C{sub 5}H{sub 5} + CO in shock waves. For C{sub 6}H{sub 4}, the only rate constant measured in the gas phase is its recombination rate at room temperature. The authors have proposed to investigate systematically the kinetics and mechanisms of this important class of molecules using two parallel laser diagnostic techniques--laser resonance absorption (LRA) and resonance enhanced multiphoton ionization mass spectrometry (REMPI/MS). In the past two years, study has been focused on the development of a new multipass adsorption technique--the {open_quotes}cavity-ring-down{close_quotes} technique for kinetic applications. The preliminary results of this study appear to be quite good and the sensitivity of the technique is at least comparable to that of the laser-induced fluorescence method.

  19. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, C.L.; Thilly, W.G.

    1999-08-10

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.

  20. LESSONS LEARNED FROM A LANDFILL SLOPE FAILURE INVOLVING

    E-Print Network [OSTI]

    Protection Agency Division of Solid & Infectious Waste Management Central Office, 122 South Front St Ohio Environmental Protection Agency Division of Solid & Infectious Waste Management Central Office Environmental Engineer Ohio Environmental Protection Agency Division of Solid & Infectious Waste Northeast

  1. LESSONS LEARNED FROM AN IMPOUNDMENT SLOPE FAILURE INVOLVING GEOSYNTHETICS

    E-Print Network [OSTI]

    underwent final closure construction in the summer of 1994. The landfill previously accepted an average for the sedimentation pond and the landfill closure was completed by 31 December 1994. The GCL used at this site, Shearbox test, Failure, Landfill, Sedimentation pond AUTHORS: Kyle E. Nay, Environmental Specialist, Ohio

  2. Tax decisions involving the cost method of inventory valuation

    E-Print Network [OSTI]

    McMenamy, Bobby Benton

    1950-01-01

    '. ?1'pQ@lg'QP ig, ". t O'Q@ ". 'Q J. '~" @~i 8 GXG C4 S6 7) PQ. &3. C'5'c' 'P~$. C" 'v'1&~ PIC&/'~%CD%'b ". QCO~1"10@7'8 ZRGQ4 3;4-'i;", ZCQQgpy P&C. $~tQ jf&53 ~~'1 $1 lg ~CXXQi1 d') + s. 2 ( C ) c XZ 3iQC9 'Nl& ACt Gf 1~1'3 y v~l8 BO&~il-"". 'XC...~15QXCX 8 pPQVXSXGlh 'KVQ~ 'K'lg OGB'5 9" Q2g p~5Q~B l&PQBQCGG. 8211CC @18 DC'. i', $Q~NDg Qf 4-. !'w QQQX' Bit&11 LAC3M8 ROC & GZ'WZl66 Q. MXQGA~ 49 M16'- BCC&QQG~g f, Q?" 4V pX'GQU4510'1 Qa iI-'Q "36~'43%43. ~~ 81 t9. @18 ' gX153TXc?:XHg ig, g. '?XO...

  3. Identifying Callous-Unemotional Subtypes among Justice-Involved Youth

    E-Print Network [OSTI]

    Magyar, Melissa Sue

    2014-08-06

    Considerable evidence suggests that the presence of a callous and unemotional interpersonal style identifies an important subgroup of antisocial and aggressive youth. Relative to other children with conduct problems, youth high on callous...

  4. The Acoustics of Narrative Involvement: Modernism, Subjectivity, Voice

    E-Print Network [OSTI]

    Napolin, Julie Beth

    2010-01-01

    narrative in his artistic credo, one whose convictions heacquired its first modern credo (101). Though his Prefacecalls the first modern credo of the novel despite being

  5. Expanding public involvement in the restoration of federal facilities

    SciTech Connect (OSTI)

    Johnson, A.W.; Rouse, N.V. [ABB Environmental Services, Inc., Arlington, VA (United States); Lawley, S.B. [SOUTHNA VFACENGCOM, North Charleston, SC (United States)

    1994-12-31

    In February of 1994, the Navy released a guidance document entitled Establishment of Restoration Advisory Boards. This guidance recommends that all Navy facilities with practicing Technical Review Committees (TRCs) transition these committees into Restoration Advisory Boards, or RABS. Subsequently, the US Environmental Protection Agency (EPA), in concert with the Department of Defense (DOD), issued similar draft guidance that also strongly recommends this transition to RABs be accomplished. The intent of creating RABs is to increase community participation in the federal facility environmental restoration process. The RAB`s mission is to provide an avenue for early, two-way communication between the affected community and the environmental decision makers. The Navy strongly believes that implementing RABs will accelerate cleanups by ensuring that the affected communities have a voice early in the restoration process. The Navy is implementing this guidance at a number of Navy facilities, including bases that have been targeted for closure. This paper discusses DOD and Navy policy and joint EPA and DOD guidelines for implementing RABs, techniques to recruit additional community members, the process for selecting RAB members, orientation of RAB members, and RAB operational considerations. It also provides insight into what the Navy has learned by establishing RABs.

  6. Multiscale treatment of mechanical contact problems involving thin polymeric layers

    E-Print Network [OSTI]

    ) and nanoelectromechanical (NEMS) systems for industrial applications [1]. This field is concerned with the study of energy wasted because of friction, which occurs in particular between mechanical components such as gears and bearings. Hence it greatly influences the design of devices containing moving parts, like motors and hard

  7. Assorted weak matrix elements involving the bottom quark

    E-Print Network [OSTI]

    C. Bernard; T. Blum; T. DeGrand; C. E. DeTar; Steven Gottlieb; U. M. Heller; J. E. Hetrick; C. McNeile; K. Rummukainen; R. L. Sugar; D. Toussaint; M. Wingate

    1996-08-15

    As part of a larger project to estimate the fB decay constant, we are recalculating fB_static using a variational smearing method in an effort to improve accuracy. Preliminary results for the static B_B parameter and HQET two point functions are also presented.

  8. Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

    E-Print Network [OSTI]

    Ding, Hui; Yan, Cai-Zhen; Shi, Honglian; Zhao, Ya-Shuo; Chang, Shi-Yang; Yu, Peng; Wu, Wen_Shuang; Zhao, Chen-Yang; Chang, Yan-Zhong; Duan, Xiang-Lin

    2011-09-21

    : #2; 2011 Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source... an important role in the management of iron metabolism. Accumulated evidence suggests that the transferrin transferrin receptor (TfTfR) pathway might be the major route of iron transport across the luminal membrane of the capillary endothelium and iron uptake...

  9. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01

    Adoption: The Case of Energy- Efficiency Audits. Resource695. Expert Group on Energy Efficiency. 2007. Realizing theDiscount Rates and Energy Efficiency. Contemporary Economic

  10. Variational stability of optimal control problems involving subdifferential operators

    SciTech Connect (OSTI)

    Tolstonogov, Aleksandr A [Institute of System Dynamics and Control Theory, Siberian Branch of the Russian Academy of Sciences, Irkutsk (Russian Federation)

    2011-04-30

    This paper is concerned with the problem of minimizing an integral functional with control-nonconvex integrand over the class of solutions of a control system in a Hilbert space subject to a control constraint given by a phase-dependent multivalued map with closed nonconvex values. The integrand, the subdifferential operators, the perturbation term, the initial conditions and the control constraint all depend on a parameter. Along with this problem, the paper considers the problem of minimizing an integral functional with control-convexified integrand over the class of solutions of the original system, but now subject to a convexified control constraint. By a solution of a control system we mean a 'trajectory-control' pair. For each value of the parameter, the convexified problem is shown to have a solution, which is the limit of a minimizing sequence of the original problem, and the minimal value of the functional with the convexified integrand is a continuous function of the parameter. This property is commonly referred to as the variational stability of a minimization problem. An example of a control parabolic system with hysteresis and diffusion effects is considered. Bibliography: 24 titles.

  11. Regulation and function of genes involved in drosophila ciliogenesis

    E-Print Network [OSTI]

    Ma, Lina

    2011-06-27

    Proneural proteins are transcription factors of the bHLH family and have a conserved role in directing neurogenesis from invertebrate to mammals. In Drosophila, proneural proteins are required for early developmental ...

  12. A time-stepping scheme involving constant coefficient matrices for ...

    E-Print Network [OSTI]

    S. Dong

    2012-06-21

    May 18, 2012 ... The issues discussed herein also apply to C0 finite element discretizations. ..... To simulate this problem, we partition the domain X along the x...

  13. Overview of Processes Involved in Spin Transfer Collisions

    SciTech Connect (OSTI)

    Buttimore, N. H.

    2008-04-30

    An outline is provided of methods for polarizing antiprotons that include the possible use of channelling in a bent crystal and also the technique of scattering off leptons or protons at a suitably small angle. In the method of channelling it is suggested that the angular dependence of the analysing power of the incident particle is cubic in the angle for single scattering in the crystal when this takes place within the region of electromagnetic hadronic interference as is most likely for channelled particles. Polarization transfer in the scattering of antiprotons off leptons or protons is discussed in addition where emphasis is laid on the angular integrals over spin observables appropriate for spin filtering.

  14. Physical Models of Noncovalent Interactions Involving Aromatic Rings

    E-Print Network [OSTI]

    Bloom, Jacob Walter Goldstein

    2014-04-17

    is expanded to the use of electric fields to reconcile unusual similarity in the substituent effects between benzene, triazine, and borazine. Substituent effects for different rings are similar as long as the electric fields of those rings are similar...

  15. Safety Guidelines for Conducting Magnetic Resonance Imaging (MRI) Experiments Involving

    E-Print Network [OSTI]

    California at San Diego, University of

    & an approved Informed Consent form. For animal studies, provide the Center with approval letter from the UCSD Institutional Animal Care and Use Committee. (4) Establish an experimenter research file and subject screening (MRI) center is dedicated solely for research. It is not a medical facility. The center houses three

  16. Emergency Response to a Transportation Accident Involving Radioactive Material

    Broader source: Energy.gov [DOE]

    The purpose of this Users Guide is to provide instructors with an overview of the key points covered in the video. The Student Handout portion of this Guide is designed to assist the instructor...

  17. PhD Subject Universit Grenoble Alpes Research Institutions Involved

    E-Print Network [OSTI]

    Condat, Laurent

    into a soil for civil engineering, for petroleum extraction and for wind-turbines as well as for the change of extracted ores from mining, or particles from pharmaceuticals where breakage energy is a significant cost The subject of this PhD is to develop groundbreaking quantitative tools for image analysis which will allow us

  18. Measurement of tau-decays involving eta-mesons

    E-Print Network [OSTI]

    Ammar, Raymond G.; Ball, S.; Baringer, Philip S.; Coppage, Don; Copty, N.; Davis, Robin E. P.; Hancock, N.; Kelly, M.; Kwak, Nowhan; Lam, H.

    1992-12-01

    The decay tau- --> nu(tau)pi-pi0eta has been observed for the first time using the CLEO-II detector at the Cornell Electron Storage Ring. The measured branching ratio (0.17 +/- 0.02 +/- 0.02)%, agrees with the CVC (conserved vector current...

  19. Fission involves a new state of nuclear matter

    E-Print Network [OSTI]

    C. Ythier; S. Hachem; G. Mouze

    2011-01-10

    The rearrangement step of nuclear fission occurs within 0.17 yoctosecond, in a new state of nuclear matter characterized by the formation of closed shells of nucleons. The determination of its lifetime is now based on the prompt neutron emission law. The width of isotopic distributions measures the uncertainty in the neutron number of the fragments. Magic mass numbers, 82 and 126, play a major role in the mass distributions. Arguments are presented in favour of an all-neutron state. The boson field responsible for the new collective interaction has to be searched for.

  20. On "Sub-Threshold" Reactions Involving Nuclear Fission

    E-Print Network [OSTI]

    M. Goldhaber; R. Shrock

    2000-11-29

    We analyze reactions of several types that are naively below threshold but can proceed because of the release of binding energy from nuclear fission and occasionally the formation of Coulombic bound states. These reactions include (i) photofission with pion production and (ii) charged current neutrino-nucleus reactions that lead to fission and/or formation of a Coulomb bound state of a $\\mu^-$ with the nucleus of a fission fragment. We comment on the possible experimental observation of these reactions.

  1. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01

    S. J. 1993. Selling Issues to Top Management. Academy ofD. 1992. Diversification Posture and Top Management Teamas A Reflection of Its Top Managers. Academy of Management

  2. An analysis of factors contributing to train-involved crashes

    E-Print Network [OSTI]

    Cooner, Scott Allen

    1995-01-01

    , light conditions, driver race and sex, accident severity, location type, and roadway class were statistically different compared to the corresponding national and statewide frequency distributions. The analysis of the research hypotheses showed...

  3. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01

    within Firms to Energy-Efficient Investments. Energy PolicyAdoption: The Case of Energy- Efficiency Audits. Resource695. Expert Group on Energy Efficiency. 2007. Realizing the

  4. Fukushima Media Involvement: Lessons Learned and Challenges - 13261

    SciTech Connect (OSTI)

    Harvey, Geoffrey L.; Johnson, Wayne L.; Koller, Greg L. [Department of Energy Pacific Northwest National Laboratory (United States)] [Department of Energy Pacific Northwest National Laboratory (United States)

    2013-07-01

    Only days after the Fukushima nuclear reactor disaster on March 11, 2011, the DOE's Pacific Northwest National Laboratory, or PNNL, found itself in a maelstrom of media attention following its announcement of the detection of minute levels of radioactive material originating from the damaged reactors 4,500 miles away. Because PNNL develops state-of-the-art ultra-sensitive radionuclide detection and monitoring systems for national security applications, and has some of the equipment operating on its Richland campus, there was little surprise when one of these sophisticated systems led PNNL to be the first to detect measurable radionuclides in the United States. On Wednesday, March 16, 2011, that system detected minuscule levels of short-lived radioactive xenon, a telltale element derived from either weapons testing or a major reactor disruption. Immediately after the detection was announced, a flurry of inquiries nearly overwhelmed staff as governments, scientific organizations, the general public, and reporters struggled to understand and estimate what impacts this disaster might have on health and environment. Over the course of about three weeks, PNNL's News and Media Relations staff and its scientists and engineers responded to more than 100 requests for information, and engaged in dozens of personal interviews with international, national, regional, and local media. While many of the interviews and resulting stories were accurate and well done, not all communication went flawlessly. In the midst of chaos and confusion, which are part of any significant crisis, hiccoughs are sure to occur. Addressed here is 'the rest of the story'. (authors)

  5. Weak interaction processes in nuclei involving neutrinos and CDM candidates

    SciTech Connect (OSTI)

    Kosmas, T. S.; Tsakstara, V. [Theoretical Physics Section, University of Ioannina, GR 45110 Ioannina (Greece); Divari, P. C. [Department of Physical Sciences, Hellenic Army Academy, Vari 16673, Attica (Greece); Sinatkas, J. [Department of Informatics and Computer Technology, TEI of Western Macedonia, GR-52100 Kastoria (Greece)

    2009-11-09

    In this work, we concentrate on the nuclear physics aspects of low-energy neutrinos and in particular on problems related to neutrino detection by terrestrial experiments, neutrino astrophysics and neutrino-nucleus interactions. The detection of low-flux neutrinos, feasible by measuring the energy recoil of the recoiling nucleus with gaseous-detectors having very-low threshold-energy, is carried out in conjunction with direct-detection of cold dark matter events and nonstandard physics searches like the neutrinoless double beta decay.

  6. FOIASI - Special Inquiry Review of Allegations InvolvingPotentialMisc...

    Energy Savers [EERE]

    Federal and contractor officials to access subcontractor personnel files for data mining of demographic information in violation of the procedures for protecting persondly...

  7. Biochemical localization of a protein involved in Gluconacetobacter...

    Office of Scientific and Technical Information (OSTI)

    States Language: English Subject: 59 BASIC BIOLOGICAL SCIENCES biofuels (including algae and biomass), bio-inspired, membrane, carbon sequestration, materials and chemistry by...

  8. An external dose reconstruction involving a radiological dispersal device

    E-Print Network [OSTI]

    Hearnsberger, David Wayne

    2007-04-25

    Council on Radiation Protection and Measurements Report No. 138 (NCRP 2001) indicates that exposures received by first responders will be important for a number of reasons, including planning for the appropriate use of key personnel in an extended...

  9. Employee Involvement Don King Washington Closure Hanford, LLC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hanford, LLC August 2012 The Next Step in Safety and Health 2012 National VPPPA Conference Protecting the Columbia River National VPPPA Conference - August 2012 E11040562 of...

  10. Discovery of ubiquitin ligases involved in cytoplasmic quality control

    E-Print Network [OSTI]

    Heck, Jarrod Wesley

    2010-01-01

    Converging concepts of protein folding in vitro and in vivo.chaperones in cellular protein folding. Current Opinion inof endoplasmic reticulum protein folding. J Cell Biol, 2001.

  11. Mechanism involved in enhancement of osteoblast differentiation by hyaluronic acid

    SciTech Connect (OSTI)

    Kawano, Michinao [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Ariyoshi, Wataru [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Iwanaga, Kenjiro [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Okinaga, Toshinori [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Habu, Manabu [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan)] [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Yoshioka, Izumi [Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, University of Miyazaki, Kiyotake, Miyazaki 889-1692 (Japan)] [Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, University of Miyazaki, Kiyotake, Miyazaki 889-1692 (Japan); Tominaga, Kazuhiro [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Oral Bioresearch Center, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Nishihara, Tatsuji, E-mail: tatsujin@kyu-dent.ac.jp [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan) [Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Kitakyushu 803-8580 (Japan); Oral Bioresearch Center, Kyushu Dental College, Kitakyushu 803-8580 (Japan)

    2011-02-25

    Research highlights: {yields} In this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. {yields} MG63 cells were incubated with BMP-2 and HA for various time periods. {yields} Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. {yields} HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation. -- Abstract: Objectives: Bone morphogenetic protein-2 (BMP-2) is expected to be utilized to fill bone defects and promote healing of fractures. However, it is unable to generate an adequate clinical response for use in bone regeneration. Recently, it was reported that glycosaminoglycans, including heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin-4-sulfate, chondroitin-6-sulfate, and hyaluronic acid (HA), regulate BMP-2 activity, though the mechanism by which HA regulates osteogenic activities has not been fully elucidated. The aim of this study was to investigate the effects of HA on osteoblast differentiation induced by BMP-2. Materials and methods: Monolayer cultures of osteoblastic lineage MG63 cells were incubated with BMP-2 and HA for various time periods. To determine osteoblastic differentiation, alkaline phosphatase (ALP) activity in the cell lysates was quantified. Phosphorylation of Smad 1/5/8, p38, and ERK proteins was determined by Western blot analysis. To elucidate the nuclear translocation of phosphorylated Smad 1/5/8, stimulated cells were subjected to immunofluorescence microscopy. To further elucidate the role of HA in enhancement of BMP-2-induced Smad signaling, mRNA expressions of the BMP-2 receptor antagonists noggin and follistatin were detected using real-time RT-PCR. Results: BMP-2-induced ALP activation, Smad 1/5/8 phosphorylation, and nuclear translocation were up-regulated when MG63 cells were cultured with both BMP-2 and HA. Western blot analysis revealed that phosphorylation of ERK protein was diminished by HA. Furthermore, the mRNA expressions of noggin and follistatin induced by BMP-2 were preferentially blocked by HA. Conclusions: These results indicate that HA enhanced BMP-2 induces osteoblastic differentiation in MG63 cells via down-regulation of BMP-2 antagonists and ERK phosphorylation.

  12. The Acoustics of Narrative Involvement: Modernism, Subjectivity, Voice

    E-Print Network [OSTI]

    Napolin, Julie Beth

    2010-01-01

    vision is incomplete; it signals that there is something more and that the frame is not a totality, but rather an artificial

  13. Worker Involvement Improves Safety at Hanford Site's Plutonium Finishing Plant

    Broader source: Energy.gov [DOE]

    Employees at the Hanford site are working together to find new and innovative ways to stay safe at the Plutonium Finishing Plant, one of the sites most complex decommissioning projects.

  14. Unsaturated geotechnics applied to geoenvironmental engineering problems involving geosynthetics

    E-Print Network [OSTI]

    Zornberg, Jorge G.

    such as geotextiles and geosynthetic clay liners (GCLs) with particular focus on capillary barriers, liner performance with contrasting hydraulic conductivity (e.g. a fine-grained soil and a nonwoven geotextile). Potential desiccation

  15. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01

    for Advanced Energy Systems (CAES) at Rutgers University. WeIAC program and shared by CAES at Rutgers University on the

  16. Draft Public Involvement Advice for Central Plateau Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    input; creating opportunities for providing input electronically via email and social media. 2. The Board advises the Tri-Party Agencies to create an informed public as...

  17. Communication methods, systems, apparatus, and devices involving RF tag registration

    DOE Patents [OSTI]

    Burghard, Brion J. (W. Richland, WA); Skorpik, James R. (Kennewick, WA)

    2008-04-22

    One technique of the present invention includes a number of Radio Frequency (RF) tags that each have a different identifier. Information is broadcast to the tags from an RF tag interrogator. This information corresponds to a maximum quantity of tag response time slots that are available. This maximum quantity may be less than the total number of tags. The tags each select one of the time slots as a function of the information and a random number provided by each respective tag. The different identifiers are transmitted to the interrogator from at least a subset of the RF tags.

  18. Dietary restriction involves NAD+ -dependent mechanisms and a

    E-Print Network [OSTI]

    Blackwell, Keith

    Natalie Moroz,1,2 Juan J. Carmona,3,5 Edward Anderson,4 Anne C. Hart,4 * David A. Sinclair5,6 * and T. Here, we explored these hypotheses in Caenorhabditis elegans using a new liquid feeding protocol. DR

  19. Processing and analysis techniques involving in-vessel material generation

    DOE Patents [OSTI]

    Schabron, John F. (Laramie, WY); Rovani, Jr., Joseph F. (Laramie, WY)

    2012-09-25

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  20. Processing and analysis techniques involving in-vessel material generation

    DOE Patents [OSTI]

    Schabron, John F. (Laramie, WY); Rovani, Jr., Joseph F. (Laramie, WY)

    2011-01-25

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  1. Decontamination Dressdown at a Transportation Accident Involving Radioactive Material

    Broader source: Energy.gov [DOE]

    The purpose of this Users Guide is to provide instructors with an overview of the key points covered in the video. The Student Handout portion of this Guide is designed to assist the instructor in...

  2. Best Practices for Emergency Response to Incidents Involving...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    but not limited to) of different battery types, vehicle types, collision damage, battery energy density and design, state of charge, cell chemistry, etc. are yet to be fully...

  3. ORIGINAL PAPER Expression of genes involved in energy mobilization

    E-Print Network [OSTI]

    Lee Jr., Richard E.

    of transcription. Keywords Antarctic midge Gluconeogenesis Trehalose Freeze tolerance Dehydration stress

  4. CHL1 is involved in human breast tumorigenesis and progression

    SciTech Connect (OSTI)

    He, Li-Hong; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Ma, Qin; Shi, Ye-Hui; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Ge, Jie; Zhao, Hong-Meng; Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Li, Shu-Fen; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Tong, Zhong-Sheng; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin

    2013-08-23

    Highlights: CHL1 is down-regulation in breast cancer tissues. Down-regulation of CHL1 is related to high grade. Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression.

  5. Student Involvement Office E. Arthur Trabant University Center

    E-Print Network [OSTI]

    Firestone, Jeremy

    , Date, Location and Time Sponsoring Organization(s) Cost or Free and Method of Obtaining Entry Who Can your friends and encourage them to invite others Creative Marketing Think of new creative ideas to help

  6. Involvement of TGF-beta in skin photoaging

    E-Print Network [OSTI]

    Choi, Won Seon, 1975-

    2005-01-01

    The goal of this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major ...

  7. Participant Subjectivity and Involvement as a Basis for Discourse Segmentation

    E-Print Network [OSTI]

    Niekrasz, John; Moore, Johanna

    2009-01-01

    We propose a framework for analyzing episodic conversational activities in terms of expressed relationships between the participants and utterance content. We test the hypothesis that linguistic features which express such ...

  8. Workers Involvement at the workplace and Job Quality in Europe

    E-Print Network [OSTI]

    Gonzlez, Mara C

    2009-01-01

    The paper focuses on workplace practices aimed at increasing workers direct voice, a job quality dimension in the European Employment Strategy for which there are no agreed indicators. It offers an analysis of the theories, ...

  9. Transcendence measures for continued fractions involving repetitive or symmetric patterns

    E-Print Network [OSTI]

    Bugeaud, Yann

    the transcendence of irrational real numbers whose expansion in some integer base can be generated by a finite to prove the transcendence of real numbers whose expansion in some integer base contains repetitive to establish e.g., the transcendence of numbers with a low complexity expansion. Their combinatorial

  10. Metal catalyzed copolymerization processes involving carbon oxides as substrates

    E-Print Network [OSTI]

    Phelps, Andrea Lee

    2005-11-01

    Studies concerning two different copolymerization processes are detailed in this dissertation: propylene oxide/CO2 coupling to afford poly(propylene carbonate) and Nbutylaziridine/ CO coupling to afford poly-??-butylalanoid. ...

  11. Top Management Involvement in the Adoption of Energy Efficiency Projects

    E-Print Network [OSTI]

    Blass, Vered; Corbett, Charles J.; Delmas, Magali A; Muthulingam, Suresh

    2011-01-01

    of Recommendations Top Management * Energy Costs/Sales TopTop Management Top Management * Energy Costs/Sales TopTop Management Top Management * Energy Costs/Sales Top

  12. A Time-Stepping Scheme Involving Constant Coefficient Matrices for ...

    E-Print Network [OSTI]

    With this formulation, the two-phase flow is characterized by the free energy of the ... ized by a free energy, different physical effects, such as complex rheology,

  13. GET INVOLVED WITH UBC THE DEPARTMENT OF ELECTRICAL AND

    E-Print Network [OSTI]

    Pulfrey, David L.

    comprehensively meet the needs of industry and our communities. There are a number of ways for members of industry systems, computer and software systems, biomedical technologies, micro/nano technologies, and energy builds meaningful, long-term relationships between companies and ECE, providing industry with direct

  14. Numerical modelling of flows involving submerged bodies and free surfaces

    E-Print Network [OSTI]

    Topper, Mathew Bernard Robert

    2011-06-28

    Kinetic energy extraction devices for ocean and river flows are often located in the vicinity of the fluid free surface. This differs from wind turbines where the atmosphere may be considered to extend to infinity for ...

  15. Analysis of supplier involvement in new product development and launch

    E-Print Network [OSTI]

    Kurapov, Herman Alex

    2006-01-01

    New or innovative products are growing in importance both in numbers and revenues, putting an extra stress on most current supply chains - defined conceptually as a buyer with a network of suppliers - as those were originally ...

  16. Central Plateau Principles Public Involvement Advice DETAILED BACKGROUND

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D BGene Network Shaping ofStaff HighlightCentralv0, 12/9/14 Central

  17. RAPID/Best Practices/Public Involvement | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource HistoryPotentialRuralUtilityScalePVGeneration JumpPublic UtilityQuintasNEPA Timelines < RAPID‎ |Public

  18. 10.0 COMMUNITY RELATIONS/PUBLIC INVOLVEMENT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-InspiredAtmosphericdevicesPPO Retirees withEnergy Special4 Mickey Leland50-1

  19. Get Involved with Home Energy Score | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy A plug-inPPLforLDRD Report11, SolarMat 4" |a,- p^AEnergyDepartment5-8,The

  20. Probative Investigation of the Thermal Stability of Wastes Involved in

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrderNATIONAL CHAIRSEnergyPresidentialGeneration |Generation

  1. TRI-PARTY AGREEMENT HANFORD PUBLIC INVOLVEMENT PLAN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With LivermoreSustainableDEPARTMENT OFEnergy- EnergyTri-State

  2. OREM continues involvement with workforce development program | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nAand DOEDepartmentNew2008Group,OAK RIDGE, Tenn. - Disposing oftimeline withof

  3. Accurate Numerical Simulations Of Chemical Phenomena Involved in Energy

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnicalInformation4563Abuse Tolerance Improvements Citation DetailsbasicProduction and

  4. Accurate Numerical Simulations Of Chemical Phenomena Involved in Energy

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnicalInformation4563Abuse Tolerance Improvements Citation DetailsbasicProduction

  5. Integrated Analysis of Protein Complexes and Regulatory Networks Involved

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers(JournalatBaBartheExpansion (Journal Article) | SciTechin

  6. Integrated Analysis of Protein Complexes and Regulatory Networks Involved

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers(JournalatBaBartheExpansion (Journal Article) | SciTechinin

  7. OpenEI:Get Involved | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsourceII JumpQuarterly Smart Grid Data available

  8. Local employee honored for community involvement | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURING OFFICE INDUSTRIALU.S.Leadership on CleanUpList ofIncrease Profits |employee

  9. Tri-Party Agreement Agencies Annual Hanford Public Involvement Survey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts[TRI-PARTY AGREEMENT AGENCIES - PUBLIC7 Tri-Party

  10. Tri-Party Agreement Hanford Public Involvement Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.WeekProducts[TRI-PARTY AGREEMENT AGENCIES - PUBLIC7 Tri-Party

  11. GC GUIDANCE ON BARTER TRANSACTIONS INVOLVING DOE-OWNED URANIUM

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,Executive Compensation References: FAR 31.205-6Applicationsnatural gas asGC

  12. Paducah WDA CERCLA Process & Public Involvement | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested PartiesBuilding energy codes havePUBLIC ADMINISTRATIONPaducah

  13. Public Involvement in the Environmental Assessment Process | Department of

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested PartiesBuildingBudget || Department ofDepartment ofNuclear

  14. NEPA-Related Public Involvement | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties -Department of EnergyNEW1 NEPA

  15. Public Involvement and Communications Committee Summaries - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProton Delivery and Removal in [Ni(P R 2 N R'AboutHanford

  16. Draft Public Involvement Advice for Central Plateau Cleanup

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit theCovalentLaboratory |Sector FullDOEUrsulaNatural

  17. Drum Involved in Idaho Incident Not Shippable to WIPP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit theCovalentLaboratory |Sectorfor $1.14 Per Gallon DrivingContacts: Dennis

  18. DOE Involvement in Consensus Negotiations for Energy Conservation Standards

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy A plug-in electric vehicle10nominate an employee forThisMillionBoilers |Department|

  19. Structural Studies of Proteins Involved in Diseases of Protein Deposition and a Protein Involved in Nitrogenase Assembly

    E-Print Network [OSTI]

    Phillips, Aaron Hale

    2010-01-01

    the product of NIFB protein. J. Biol. Chem. , 1994.Cleavage of structural proteins during the assembly of theof Escherichia coli NusA with protein N of phage lambda.

  20. A Self-advocacy Program for Students with Disabilities: Adult Outcomes and Advocacy Involvement One to Six Years after Involvement

    E-Print Network [OSTI]

    Roberts, Eric

    2013-03-08

    The Texas Statewide Youth Leadership Forum (TXYLF) provides self-advocacy training to high school youths with disabilities. TXYLF is an enhanced version of the Youth Leadership Forum (YLF) that is comprised of an initial five day training, a nine...

  1. All projects in the Center involve multiple Co-PIs, with the majority of the projects involving Co-PIs from

    E-Print Network [OSTI]

    Eustice, Ryan

    Thrust I is developing the fundamental experimental and computational techniques for controlling on the Center website. Research in the Center The Center is Guided by an External Advisory Board Industry Dr. Jeffrey Marks, Lam Research Inc. Dr. Tim Sommerer, General Electric Dr. Nick Fuller, IBM Dr. Mark

  2. Cytochromes P450: Inhibition of CYP2A Enzymes Involved in Xenobiotic Metabolism and Generation of CYP26 Enzymes Involved in Retinoic Acid Metabolism

    E-Print Network [OSTI]

    Stephens, Eva Susanne

    2012-08-31

    step. Unfortunately, this protein appeared to be inactive according to reduced carbon monoxide difference spectrum analysis and assays of RA metabolism. As a result, further optimization will be required to reach the original goal set forth to generate...

  3. This invention relates to methods of generating NP gallium nitride (GaN) across large areas (>1 cm.sup.2) with controlled pore diameters, pore density, and porosity. Also disclosed are methods of generating novel optoelectronic devices based on porous GaN. Additionally a layer transfer scheme to separate and create free-standing crystalline GaN thin layers is disclosed that enables a new device manufacturing paradigm involving substrate recycling. Other disclosed embodiments of this invention relate to fabrication of GaN based nanocrystals and the use of NP GaN electrodes for electrolysis, water splitting, or photosynthetic process applications.

    DOE Patents [OSTI]

    Zhang, Yu; Sun, Qian; Han, Jung

    2015-12-08

    This invention relates to methods of generating NP gallium nitride (GaN) across large areas (>1 cm.sup.2) with controlled pore diameters, pore density, and porosity. Also disclosed are methods of generating novel optoelectronic devices based on porous GaN. Additionally a layer transfer scheme to separate and create free-standing crystalline GaN thin layers is disclosed that enables a new device manufacturing paradigm involving substrate recycling. Other disclosed embodiments of this invention relate to fabrication of GaN based nanocrystals and the use of NP GaN electrodes for electrolysis, water splitting, or photosynthetic process applications.

  4. Identification of ubiad1 as a gene involved in cardiovascular homeostasis and development

    E-Print Network [OSTI]

    Hegarty, Jeffrey Miles

    2011-01-01

    gene causes defects of bioenergetics and de novo pyrimidineparticipate in cardiac bioenergetics (Kumar et al. , 2009),defects affecting bioenergetics (Lpez- Martn et al. ,

  5. High-performance ternary blend polymer solar cells involving both energy transfer and hole relay processes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lu, Luyao; Chen, Wei; Xu, Tao; Yu, Luping

    2015-06-04

    The integration of multiple materials with complementary absorptions into a single junction device is regarded as an efficient way to enhance the power conversion efficiency (PCE) of organic solar cells (OSCs). However, because of increased complexity with one more component, only limited high-performance ternary systems have been demonstrated previously. Here we report an efficient ternary blend OSC with a PCE of 9.2%. We show that the third component can reduce surface trap densities in the ternary blend. Detailed studies unravel that the improved performance results from synergistic effects of enlarged open circuit voltage, suppressed trap-assisted recombination, enhanced light absorption, increasedmorehole extraction, efficient energy transfer and better morphology. The working mechanism and high device performance demonstrate new insights and design guidelines for high-performance ternary blend solar cells and suggest that ternary structure is a promising platform to boost the efficiency of OSCs.less

  6. Title 25 USC 3504 Leases, business agreements, and rights-of-way involving

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-EnhancingEt Al., 2013)Open EnergyTinox Jump to:,11 Protection of2CFRenergy development

  7. Gambierdiscus toxicus from the Caribbean: A Source of Toxins Involved in Ciguatera

    E-Print Network [OSTI]

    of St. Thomas, us. Virgin Islands. The detritus was fractionated by sieving and then pro- cessed-soluble (PPT-B) toxic components that were heat- stable and precipitated in cold acetone. Intraperitoneal in Brewer's Bay on the south side of St. Thomas, U.S. Virgin Islands. The site is a sandy- bottomed, well

  8. Investigation of the absorption principle involved in the analyses and titrations performed in high frequency fields

    E-Print Network [OSTI]

    Griffin, James Hilton

    1940-01-01

    , demnding upon the ohoioe of titration frequen op. lf the titrating agent shows ths hidaer abserytien, its exsess at the end point osuses the ohange in Che output of the osoillator. If the substanoe being titrate4 shows the higher absorptiony its... for 4h? detensinabion of tho vari- 5 ation of dieleotrio constant in volunetrio analysis, wss completely rebuilt ~ Although the siss type of equi~at was used, several ohsngos were made in order to increase stability aad sensitivity. The power supply...

  9. Is lipid translocation involved during endo-and exocytosis? Philippe F. Devaux*

    E-Print Network [OSTI]

    by a change in the proportion of inner and outer lipids. It is shown that the formation of microvesicles several hours which is quite incompatible with the time scale of a continuous endocytotic process

  10. Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species

    E-Print Network [OSTI]

    Pilpel, Yitzhak

    for oxidative respiration or fermentation and are efficiently translated in aerobic or anaerobic species anticodons translating glutamic acid (E), proline (P), glutamine (Q), arginine (R) and leucine (L) can

  11. Physical processes involved in strip electrode welding using the method of slatted splicing

    SciTech Connect (OSTI)

    Bushma, V. O. [Moscow State Technological University 'Stankin' (Russian Federation)

    2010-12-15

    Physical processes that take place in a strip electrode during welding using the slatted splicing technique are considered. Flowing of the welding current in the electrode is shown to be the key process which determines electrode heating and melting. Technological receipts are proposed that allow obtaining high-quality welds by the method of slatted splicing.

  12. NJITMAGA-HARDCOPY Some of those involved in the public policy debate may have

    E-Print Network [OSTI]

    Haimovich, Alexander

    of electricity and bulk power sales. New Jersey restructured electric markets in 1999 when the State Legislature ended the vertical integration of the state's electric utilities and required them to divest or functionally transfer ownership of their electric generating plants. Utilities still deliver elec- tricity

  13. Regions Involved in the Oligomerization and Activity of the Spiral Forming Nitrilase Cyanide Dihydratase

    E-Print Network [OSTI]

    Park, Jason M

    2014-05-22

    Nitrilases offer an economic and environmentally friendly solution for the production of valuable chemicals, and the degradation of toxic industrial nitrile wastes. A lack of fine structural data has impeded rational ...

  14. Systematic identification of genes and transduction pathways involved in radio-adaptive response

    SciTech Connect (OSTI)

    Wu, Honglu

    2015-05-22

    Low doses of radiation have been shown to protect against the biological effects of later exposure to toxic levels of radiation. In this study, we propose to identify the molecular mechanisms of this adaptive response by systematically identifying the genes that play a role in radio-protection. In the original proposal, a human cell line that is well-documented to exhibit the radio-adaptive effect was to be used. In this revised study plan, we will use a mouse model, C57BL/6, which has also been well investigated for radio-adaptation. The goal of the proposed study is to enhance our understanding of cellular responses to low doses of radiation exposure at the molecular level.

  15. Taking Man Out of the Loop: Methods to Reduce Human Involvement in Search and Surveillance Applications

    E-Print Network [OSTI]

    Brink, Kevin Michael

    2012-02-14

    . The second area of research is the autonomous exploration of hallways or other urban- canyon environments in the absence of a global positions system (GPS) using only an inertial motion unit (IMU) and a monocular camera. Desired paths that generate... accurate vehicle state estimates for simple ground vehicles are identi ed and the bene ts of integrated estimation and control are investigated. It is demonstrated that considering estimation accuracy is essential to produce e cient guidance and control...

  16. Sustainability Research Opportunities in India Cornell researchers and students have been actively involved in Indian

    E-Print Network [OSTI]

    Walter, M.Todd

    Title: Sustainability Research Opportunities in India Abstract: Cornell researchers and students and current Sustainability Coordinator Daniel Roth, met with these organizations during a recent trip to India and will provide an overview of potential India-Cornell partnerships for sustainability. Topics include

  17. The chaplins: a family of hydrophobic cell-surface proteins involved

    E-Print Network [OSTI]

    Elliot, Marie A.

    in Streptomyces coelicolor Marie A. Elliot,1,4 Nitsara Karoonuthaisiri,2 Jianqiang Huang,3 Maureen J. Bibb,1

  18. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival

    E-Print Network [OSTI]

    2007-01-01

    + mice treated with 500 ppm celecoxib. *, P = 0.04 indicatesMean+SD) Putrescine Control Celecoxib, 500 ppm SpermidineArginine, polyamines, celecoxib, meat, familial colorectal

  19. A Genetic Algorithm Applied to Graph Problems Involving Subsets of Vertices

    E-Print Network [OSTI]

    Wainwright, Roger L.

    and Computer Sciences University of Tulsa University of Tulsa 600 South College Avenue 600 South College Avenue Tulsa, OK 74104 USA Tulsa, OK 74104 USA rogerw@utulsa.edu Abstract - Many graph problems seek subsets

  20. Palladium-Catalyzed Coupling Reactions of Biphenylene with Olefins, Arylboronic Acids, and Ketones Involving

    E-Print Network [OSTI]

    Jones, William D.

    Palladium-Catalyzed Coupling Reactions of Biphenylene with Olefins, Arylboronic Acids, and Ketones the catalytic C-C bond activation and functionalization of biphenylene under nickel, palladium, or platinum, palladium-catalyzed cross-coupling of biphenylene with olefins, arylboronic acids, and ketones occurred

  1. Phase-Changing Ionic Liquids: CO2 Capture with Ionic Liquids Involving Phase Change

    SciTech Connect (OSTI)

    2010-07-01

    IMPACCT Project: Notre Dame is developing a new CO2 capture process that uses special ionic liquids (ILs) to remove CO2 from the gas exhaust of coal-fired power plants. ILs are salts that are normally liquid at room temperature, but Notre Dame has discovered a new class of ILs that are solid at room temperature and change to liquid when they bind to CO2. Upon heating, the CO2 is released for storage, and the ILs re-solidify and donate some of the heat generated in the process to facilitate further CO2 release. These new ILs can reduce the energy required to capture CO2 from the exhaust stream of a coal-fired power plant when compared to state-ofthe- art technology.

  2. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis W OA

    E-Print Network [OSTI]

    Pauly, Markus

    , with a lower content of pectin and an abundance of arabinoxylan rather than xyloglucan. Pectin is a complex

  3. Identification of a Xylogalacturonan Xylosyltransferase Involved in Pectin Biosynthesis in Arabidopsis

    E-Print Network [OSTI]

    Jensen, Jacob K.

    2010-01-01

    Scheller, H.V. (2002). Arabinoxylan biosynthesis in wheat.and an abundance of arabinoxylan rather than xyloglucan.acid backbone, like the arabinoxylan arabinosyltransferase (

  4. Risk assessment involving the land disposal of animal waste on Central Texas dairies

    E-Print Network [OSTI]

    Lee, Thomas Chadwick

    1999-01-01

    Land disposal of animal waste is an increasing problem for dairies in central Texas Once isolated, many producers now and themselves surrounded by towns and subdivisions. Many of these new neighbors are showing an increasing concern about potential...

  5. Katherine Tubby For over a decade, numerous volunteers have been involved in a Forest Research (FR)-

    E-Print Network [OSTI]

    ;Our Research Biometrics, Surveys and Statistics overview Woodfuel and biomass energy Simulating and Statistics Fully understanding the potential of our woodland resources requires an accurate picture and statistics contribute a range of critical scientific approaches, from statistical analysis and data

  6. Self-determination and student involvement in standards-based reform

    E-Print Network [OSTI]

    Wehmeyer, Michael L.; Field, Sharon; Doren, Bonnie; Jones, Bonnie; Mason, Christine

    2004-01-01

    of the current educational context. We particularly examine the role of promoting self-determination in light of federal standards-based reform initiatives. We conclude that school reform efforts provide an opportunity to infuse instruction in self...

  7. THE PHOTOCHEMISTRY AND KINETICS OF GAS PHASE REACTIONS INVOLVING HO AND C1 RADICALS

    E-Print Network [OSTI]

    Nelson, Herbert Hoffman

    2013-01-01

    VUV measurements and UV measurements meet but don't overlapdetermined by near UV absorption measurements. The productlimit (by UV absorption measurements) by this procedure,

  8. Environmental diagnostic analysis of ground water bacteria and their involvement in utilization of aromatic compounds

    SciTech Connect (OSTI)

    Wear, J.E. Jr.

    1993-05-01

    The objective of this study was to examine the hypothesis that select functional groups of bacteria from pristine sites have an innate ability to degrade synthetic aromatics that often contaminate groundwater environments,due to exposure to naturally occurring recalcitrant aromatics in their environment. This study demonstrates that subsurface microbial communities are capable of utilizing lignin and humic acid breakdown products. Utilizers of these compounds were found to be present in most all the wells tested. Even the deepest aquifer tested had utilizers present for all six of the aromatics tested. Highest counts for the aromatics tested were observed with the naturally occurring breakdown products of either lignin or humic acid. Carboxylic acids were found to be an important sole carbon source for groundwater bacteria possibly explained by the fact that they are produced by the oxidative cleavage of aromatic ring structures. The carbohydrate sole carbon sources that demonstrated the greatest densities were ones commonly associated with humics. This study indicates that utilization of naturally occurring aromatic compounds in the subsurface is an important nutritional source for groundwater bacteria. In addition, it suggests that adaptation to naturally occurring recalcitrant substrates is the origin of degradative pathways for xenobiotic compounds with analogous structure. This work has important implications for in situ bioremediation as a method of environmental cleanup.

  9. FapR, a Bacterial Transcription Factor Involved in Global Regulation of Membrane Lipid Biosynthesis

    E-Print Network [OSTI]

    Schujman, Gustavo E

    Bacterial cells exert exquisite control over the biosynthesis of their membrane lipids, but the mechanisms are obscure. We describe the identification and purification from Bacillus subtilis of a transcription factor, FapR, ...

  10. inappropriate, confusing and misleading to have different health communities (for humans and animals) involved

    E-Print Network [OSTI]

    years war against it in Principe, Portuguese West Africa. In Costa B.F.B. Bailliere, Tindall and Cox

  11. Consumer perceptions of wine packaging design styles : the moderating role of involvement

    E-Print Network [OSTI]

    Arnold, Rene Claus Gerhard

    2013-07-03

    The influence of packaging design (PD) on consumer choice is well documented, most notably through its perceived attractiveness and the product beliefs it can generate. However, these aspects of PDs influence have been ...

  12. Applying Machine Learning Methods to Suggest Network Involvement and Functionality of Genes in Saccharomyces cerevisiae

    E-Print Network [OSTI]

    Amthauer, Heather A.

    2008-10-10

    Elucidating genetic networks provides the foundation for the development of new treatments or cures for diseased pathways, and determining novel gene functionality is critical for bringing a better understanding on how an ...

  13. Laser-driven deflection arrangements and methods involving charged particle beams

    DOE Patents [OSTI]

    Plettner, Tomas (San Ramon, CA); Byer, Robert L. (Stanford, CA)

    2011-08-09

    Systems, methods, devices and apparatus are implemented for producing controllable charged particle beams. In one implementation, an apparatus provides a deflection force to a charged particle beam. A source produces an electromagnetic wave. A structure, that is substantially transparent to the electromagnetic wave, includes a physical structure having a repeating pattern with a period L and a tilted angle .alpha., relative to a direction of travel of the charged particle beam, the pattern affects the force of the electromagnetic wave upon the charged particle beam. A direction device introduces the electromagnetic wave to the structure to provide a phase-synchronous deflection force to the charged particle beam.

  14. The role of genetic counseling in the elective termination of pregnancies involving fetuses with disabilities

    E-Print Network [OSTI]

    Stough, Laura

    2002-01-01

    for giving birth to an in- fant with a disability. Demographic characteristics of the par- ticipants can be found in Table 1. The genetic counseling center used in this study pro- vided services to the local community and surrounding area and was located... to the exploratory nature of this study, an effect size of .30 was chosen by the researcher: When the researcher is un- able to make an educated guess as to the effect size present in the population or when there is little prior research in an area...

  15. Redox linked flavin sites in extracellular decaheme proteins involved in microbe-mineral electron transfer.

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Edwards, Marcus J.; White, Gaye F.; Norman, Michael; Tome-Fernandez, Alice; Ainsworth, Emma; Shi, Liang; Fredrickson, Jim K.; Zachara, John M.; Butt, Julea N.; Richardson, David J.; et al

    2015-07-01

    Extracellular microbe-mineral electron transfer is a major driving force for the oxidation of organic carbon in many subsurface environments. Extracellular multi-heme cytochromes of the Shewenella genus play a major role in this process but the mechanism of electron exchange at the interface between cytochrome and acceptor is widely debated. The 1.8 x-ray crystal structure of the decaheme MtrC revealed a highly conserved CX?C disulfide that, when substituted for AX?A, severely compromised the ability of S. oneidensis to grow under aerobic conditions. Reductive cleavage of the disulfide in the presence of flavin mononucleotide (FMN) resulted in the reversible formation ofmorea stable flavocytochrome. Similar results were also observed with other decaheme cytochromes, OmcA, MtrF and UndA. The data suggest that these decaheme cytochromes can transition between highly reactive flavocytochromes or less reactive cytochromes, and that this transition is controlled by a redox active disulfide that responds to the presence of oxygen.less

  16. UNIVERSITY OF ST ANDREWS RISK ASSESSMENT FOR WORK INVOLVING LASER/LED EQUIPMENT

    E-Print Network [OSTI]

    Greenaway, Alan

    inexperience, open beam paths, use of periscopes, high voltages, liquid cooling, lone work, unauthorised access

  17. E-cadherin junction formation involves an active kinetic nucleation process

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Biswas, Kabir H.; Hartman, Kevin L.; Yu, Cheng -han; Harrison, Oliver J.; Song, Hang; Smith, Adam W.; Huang, William Y. C.; Lin, Wan -Chen; Guo, Zhenhuan; Padmanabhan, Anup; et al

    2015-08-19

    Epithelial (E)-cadherin-mediated cellcell junctions play important roles in the development and maintenance of tissue structure in multicellular organisms. E-cadherin adhesion is thus a key element of the cellular microenvironment that provides both mechanical and biochemical signaling inputs. Here, we report in vitro reconstitution of junction-like structures between native E-cadherin in living cells and the extracellular domain of E-cadherin in a supported membrane. Junction formation in this hybrid live cell-supported membrane configuration requires both active processes within the living cell and a supported membrane with low E-cad-ECD mobility. The hybrid junctions recruit ?-catenin and exhibit remodeled cortical actin. Observations suggest thatmorethe initial stages of junction formation in this hybrid system depend on the trans but not the cis interactions between E-cadherin molecules, and proceed via a nucleation process in which protrusion and retraction of filopodia play a key role.less

  18. The Conducting of a Mining Negotiation Showing the Scheme of Engineering Involved

    E-Print Network [OSTI]

    Hansen, George T.

    1911-01-01

    as follows:- 1 - 7-1/2 "E" Breaker 55 H.P. 1 - #6 "B" Elevator 12 " 1 - 20" Conveyor 3 " 'Transmission 2 " Total 72 " Motor Power 75 " Two sections each as follows 1 - #4 Breaker 16 B.P. 2 - 48" x 16* Screens --19 TT 1 - 18" Elevator 11 TT 2 - 36...,r trommels fitted with 1 m/m perforated sheet steel covering. The oversize from these trommels representing ore between 9' m/m and 1 m/m feeds the 25* Hancock Jig which produces concentrates in the 1st, 2nd, and third compartments, middlings...

  19. Temporal metaphorics : participation and involvement in time-based media environments

    E-Print Network [OSTI]

    Gossmann, Joachim

    2012-01-01

    power over us than the physical frame of its display might suggest: we can become completely absorbed in cellphone

  20. Signals Involved in Arabidopsis Resistance to Trichoplusia ni Caterpillars Induced by Virulent and Avirulent Strains

    E-Print Network [OSTI]

    Pierce, Naomi E.

    -type Arabidopsis ecotype Columbia plants that were infected with P. syringae pv. maculicola strain ES4326 (Psm ES with Psm ES4326(avrRpt2) or Psm ES4326(avrB), nahG transgenic and npr1 mutant plants (which are more, infected with Psm ES4326 not expressing avrRpt2 or avrB, which elicits disease, became more susceptible

  1. FRET analysis of splicing factors involved in exon and intron definition in living cells

    E-Print Network [OSTI]

    Ellis, Jonathan

    2008-01-01

    I have analyzed the interactions between SR proteins and splicing components that are bound at the 5 or 3 splice site using fluorescence resonance energy transfer (FRET) microscopy. The SR proteins interact with the U1 ...

  2. Theoretical Investigations of Cycloadditions and Subsequent Transformations Involving Allenes and Arenes to Form Complex Polycycles

    E-Print Network [OSTI]

    Pham, Hung Viet

    2015-01-01

    Reactions of Allene with Benzene and Butadiene: Concerted,Reactions of Allene with Benzene and Butadiene: Concerted,For select examples with benzene as a diene: (a) Ciganek, E.

  3. Global prevalence and distribution of genes and microorganisms involved in mercury methylation

    SciTech Connect (OSTI)

    Podar, Mircea; Gilmour, C C; Brandt, Craig C; Bullock, Allyson L; Brown, Steven D; Crable, Bryan R; Palumbo, Anthony Vito; Somenahally, Anil C; Elias, Dwayne A

    2015-01-01

    Mercury methylation produces the neurotoxic, highly bioaccumulative methylmercury (MeHg). Recent identification of the methylation genes (hgcAB) provides the foundation for broadly evaluating microbial Hg-methylation potential in nature without making explicit rate measurements. We queried hgcAB diversity and distribution in all available microbial metagenomes, encompassing most environments. The genes were found in nearly all anaerobic, but not in aerobic, environments including oxygenated layers of the open ocean. Critically, hgcAB was effectively absent in ~1500 human microbiomes, suggesting a low risk of endogenous MeHg production. New potential methylation habitats were identified, including invertebrate guts, thawing permafrost, coastal dead zones , soils, sediments, and extreme environments, suggesting multiple routes for MeHg entry into food webs. Several new taxonomic groups potentially capable of Hg-methylation emerged, including lineages having no cultured representatives. We begin to address long-standing evolutionary questions about Hg-methylation and ancient carbon fixation mechanisms while generating a new global view of Hg-methylation potential.

  4. Black African Women's Motivations for Involvement in Southern African Liberation Struggles

    E-Print Network [OSTI]

    Jalufka, Alaina 1987-

    2011-04-26

    Since the introduction of colonialism, African women have frequently been ignored in and excluded from political life in southern Africa. However, many women participated as freedom fighters and activists in southern ...

  5. Social Media Scavenger Hunt to Bolster Resident Involvement at an Academic Conference

    E-Print Network [OSTI]

    Fix, M; Mallin, M P; Stroud, S

    2014-01-01

    an educational adjunct at an ACEP conference, a smartphonepiloted this during the ACEP Scientific Assembly by havinghunt during 3 days at the ACEP Scientific Assembly in

  6. A system theoretic safety analysis of U.S. Coast Guard aviation mishap involving CG-6505

    E-Print Network [OSTI]

    Hickey, Jon (Jon Patrick)

    2012-01-01

    During a 22-month period, between 2008 and 2010, the U.S. Coast Guard experienced seven Class-A aviation mishaps resulting in the loss of 14 Coast Guard aviators and seven Coast Guard aircraft. This represents the highest ...

  7. AI.IALYSIS OF RINGING RECOVERIES OF RUFF INVOLVING SOUTHERN AFRICA

    E-Print Network [OSTI]

    de Villiers, Marienne

    and India to Siberia, east of the Ural Mountains (6o"n). RESULTS ( a) Recoveries. Of the 17 long in Uatarii and Uganda, one in lran, one in Russia and eight in Siberia. fn addition, two foreign-ringed Ruffs NUMBER OF RECOVERIES !iHERE MORE THAN ONE. 76 #12;The birds recovered in Russia and Iran \\dere both

  8. Issues Associated with IAEA Involvement in Assured Nuclear Fuel Supply Arrangements

    SciTech Connect (OSTI)

    Kessler, Carol E.; Mathews, Carrie E.

    2008-02-08

    Assured nuclear fuel supply has been discussed at various times as a mechanism to help limit expansion of enrichment and reprocessing (E&R) capability beyond current technology holders. Given the events in the last few years in North Korea and Iran, concern over weapons capabilities gained from acquisition of E&R capabilities has heightened and brought assured nuclear fuel supply (AFS) again to the international agenda. Successful AFS programs can be valuable contributions to strengthening the nonproliferation regime and helping to build public support for expanding nuclear energy.

  9. SO2907, A Putative TonB-dependent Receptor, Is Involved in Dissimilato...

    Office of Scientific and Technical Information (OSTI)

    English Subject: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AMINO ACIDS; BACTERIA; BINDING ENERGY; CALORIMETRY; CARBONYLS; ELECTRONS; FLUORESCENCE; GENES;...

  10. Optimal Design for Problems Involving Flow and Transport Phenomena in Saturated

    E-Print Network [OSTI]

    of injection wells p set of model parameters q Darcy velocity, or volumetric ux p uid pressure q y ; q z maximum injection rate Q T total net pumping rate rate Q e T total extraction rate Q max T maximum total

  11. The Relationship Between Parental Involvement and High School Graduation Among Different Ethnicity Groups

    E-Print Network [OSTI]

    Xu, Jing

    2012-01-01

    and the Childs School Performance. Child Development 58(5):Their Children's School Performance. American Educationalplans, contacting school about performance) are included

  12. Atmospheric Aerosols Aging Involving Organic Compounds and Impacts on Particle Properties

    E-Print Network [OSTI]

    Qiu, Chong

    2013-02-01

    In the first part of this dissertation, we study the aging of soot, a representative type of primary aerosols, in the presence of OH-initiated oxidation products of toluene. Monodisperse soot particles are introduced into an environmental chamber...

  13. Corporate involvement in disaster response and recovery : an analysis of the Gujarat Earthquake

    E-Print Network [OSTI]

    Sayegh, Tracy, 1976-

    2004-01-01

    Disaster vulnerability is a serious issue in developing countries where globalization, development patterns, poverty and environmental degradation are placing more people at risk to natural disasters. Recent appeals for ...

  14. The PPH1 phosphatase is speci cally involved in LHCII dephosphorylation and state transitions

    E-Print Network [OSTI]

    Halazonetis, Thanos

    of the thylakoid membranes. We demonstrate that loss of PPH1 leads to an increase in the antenna size of photo phosphatases | thylakoid | plastid Plants are critically dependent on light as a source of energy to drive to adapt to such changes in their light environment, optimize photosynthesis, prevent photo

  15. Asbestos precautions If your work involves disturbing existing building materials, complete the asbes-

    E-Print Network [OSTI]

    McLaughlin, Richard M.

    . Contact EHS at 962-5507 for guidance. The University policy is at ehs.unc.edu>Industrial Hygiene to control exposure: ehs.unc.edu>Industrial Hygiene>Heat Stress. Working in confined spaces If you have at ehs.unc.edu>Manuals>Industrial Maintenance and Construction/Support Ser- vices Safety Manual

  16. Sensitivity and uncertainty analysis of accident management strategies involving multiple decisions

    SciTech Connect (OSTI)

    Jae, Moosung; Milici, A.D.; Kastenberg, W.E.; Apostolakis, G.E. (Univ. of California, Los Angeles, CA (United States))

    1993-10-01

    A framework for assessing severe accident management strategies is presented using a new analytical tool, namely, influence diagrams. This framework includes multiple and sequential decisions, sensitivity analysis, and uncertainty propagation, and is applied to a proposed set of strategies for a pressurized water reactor station blackout sequence. The influence diagram associated with these strategies is constructed and evaluated. Each decision variable, represented by a node in the influence diagram, has an uncertainty distribution associated with it. Using the mean value of these distributions, a best estimate assessment is performed, and each strategy is ranked with respect to the conditional frequency of early containment failure (ECF). For the preferred alternative, the sensitivity of the results to values of the input variables is investigated. The sensitivity of the ranking itself is then considered. The distributions of the uncertain variables are also propagated through the influence diagram to rank the alternatives with respect to the uncertainty associated with the calculated conditional frequency of ECF. Finally, the sensitivity of the variance of the output distribution, given the preferred decision alternative, to the uncertainty of the input variables is investigated.

  17. Phi ({Phi}) and psi ({Psi}) angles involved in malarial peptide bonds determine sterile protective immunity

    SciTech Connect (OSTI)

    Patarroyo, Manuel E.; Moreno-Vranich, Armando; Bermudez, Adriana

    2012-12-07

    Highlights: Black-Right-Pointing-Pointer Phi ({Phi}) and psi ({Psi}) angles determine sterile protective immunity. Black-Right-Pointing-Pointer Modified peptide's tendency to assume a regular conformation related to a PPII{sub L}. Black-Right-Pointing-Pointer Structural modifications in mHABPs induce Ab and protective immunity. Black-Right-Pointing-Pointer mHABP backbone atom's interaction with HLA-DR{beta}1{sup Asterisk-Operator} is stabilised by H-bonds. -- Abstract: Modified HABP (mHABP) regions interacting with HLA-DR{beta}1{sup Asterisk-Operator} molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an acceptable immune response due to the critical role of their {Phi} and {Psi} torsion angles. These angle's critical role was determined in such highly immunogenic, protection-inducing response against experimental malaria using the conformers (mHABPs) obtained by {sup 1}H-NMR and superimposed into HLA-DR{beta}1{sup Asterisk-Operator }-like Aotus monkey molecules; their phi ({Phi}) and psi ({Psi}) angles were measured and the H-bond formation between these molecules was evaluated. The aforementioned mHABP propensity to assume a regular conformation similar to a left-handed polyproline type II helix (PPII{sub L}) led to suggesting that favouring these conformations according to their amino acid sequence would lead to high antibody titre production and sterile protective immunity induction against malaria, thereby adding new principles or rules for vaccine development, malaria being one of them.

  18. Overview of Scientific Issues Involved in Selection of Polymers for PV Applications: Preprint

    SciTech Connect (OSTI)

    Kempe, M.

    2011-07-01

    Encapsulant materials used in photovoltaic (PV) modules serve multiple purposes. They physically hold components in place, provide electrical insulation, reduce moisture ingress, optically couple superstrate materials (e.g., glass) to PV cells, protect components from mechanical stress by mechanically de-coupling components via strain relief, and protect materials from corrosion. To do this, encapsulants must adhere well to all surfaces, remain compliant, and transmit light after exposure to temperature, humidity, and UV radiation histories. Here, a brief review of some of the polymeric materials under consideration for PV applications is provided, with an explanation of some of their advantages and disadvantages.

  19. The `catalytic triad' mechanism, which involves a serine, aspartic acid, has become synonymous with serine pr

    E-Print Network [OSTI]

    Paetzel, Mark

    with serine pr recently, mechanistically novel serine proteases have These proteases use hydroxyl/e-amine their involvementin I FIgwe (a)The classical catalytic triad. (b) dyad. (c) The hydroxyl/a-amine dyad. The Ser type of hydroxyl/amine cata- lytic dyad, similar to the Ser/Lys dyad, 30 is found at the active

  20. An analysis of the protein interactions involved in classical nuclear import

    E-Print Network [OSTI]

    Reedy, Brian Michael Thomas

    1999-01-01

    NLS contained in the N-terminal domain 14 2. 1 The reagents used in the modification of proteins and peptides . . . 20 2. 2 The pMAL-c2 vector contains the inducible P?, promoter positioned to transcribe a mal E-lac Za gene fusion... KKYENVVIKRSPRKRGRPRKD Yeast SWI5 gene product bipartite KRPAATKKAGQAKKKKL Xenopus nucleoplasmin bipartite It has been demonstrated that the attachment, either by chemical coupling or genetic fusion, of one of these passport sequences to a non- nuclear protein...

  1. Genes involved in long-chain alkene biosynthesis in Micrococcus luteus

    E-Print Network [OSTI]

    Beller, Harry R.

    2010-01-01

    polytetrafluoroethylene (PTFE)-lined septa. Assay mixturescontacted only glass or PTFE. Extraction of long-chain30- ml glass tubes with PTFE-lined screw-cap closures were

  2. Understanding Postranslational Modifications Involved in Adi3 Programmed Cell Death Signaling

    E-Print Network [OSTI]

    Avila Pacheco, Julian Ricardo, 1983-

    2012-10-15

    Programmed cell death (PCD) is an active process by which organisms coordinate the controlled destruction of cells. In tomato, the protein kinase Adi3 (AvrPto-dependent Pto-interacting kinase 3), acts as a negative ...

  3. Query Plans for Conventional and Temporal Queries Involving Duplicates and Ordering

    E-Print Network [OSTI]

    Snodgrass, Richard T.

    substantially from built- in temporal support in the DBMS. To achieve this, temporal query representation for providing temporal support both via a stand-alone temporal DBMS and via a layer on top of a conventional DBMS. By capturing duplicate removal and retention and order preservation for all queries, as well

  4. Database, Spatial Spatial databases are the foundation for computer-based applications involving spatially

    E-Print Network [OSTI]

    managed using a particular type of software called a database management system (DBMS) that allows be implemented in a GIS, in a computer-assisted design (CAD) system coupled with a DBMS, in a universal server

  5. Search for neutrinoless tau decays involving pi(0) or eta mesons

    E-Print Network [OSTI]

    Ammar, Raymond G.; Baringer, Philip S.; Bean, Alice; Besson, David Zeke; Coppage, Don; Darling, C.; Davis, Robin E. P.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, Nowhan

    1997-08-01

    We have searched for lepton flavor violating decays of the tau lepton using final states with an electron Or a muon and one or two pi(0) or eta mesons but no neutrinos. The data used in the search were collected with the CLEO II detector...

  6. Resource allocatiion: sequential data collection for reliability analysis involving systems and component level data

    SciTech Connect (OSTI)

    Anderson-cooke, Christine M [Los Alamos National Laboratory

    2010-01-01

    In analyzing the reliability of complex systems, several types of data from full-system tests to component level tests are commonly available and are used. After a preliminary analysis, additional resources may be available to collect new data. The goal of resource allocation is to identify the best new data to collect to maximally improve the prediction of system reliability. While several possible definitions of 'maximally improve' are possible, we focus on reducing the uncertainty or the width of the uncertainty interval for the prediction of system reliability at a user-specified age(s). In this paper, we present an algorithm that allows us to estimate the anticipated improvement to the analysis with the addition of new data, based on current understanding of all of the statistical model parameters. This quantitative assessment of the anticipated improvement can be helpful to justify the benefits of collecting new data. Additionally by comparing different potential allocations, it is possible to determine what new data should be collected to improve our understanding of the response. This optimization takes into account the relative cost of different data types and can be based on flexible allocation options, or subject to logistical constraints.

  7. Children's involvement in care order decision-making: A cross-country analysis.

    E-Print Network [OSTI]

    Berrick, JD; Dickens, J; Ps, T; Skivenes, M

    2015-01-01

    118. Skivenes, M. (2011). Norway Toward a child centricprinciples and the cases of Norway and the UK. Journal ofa comparasion of England Norway and the United States (

  8. Metal Catalyzed Formation of Aliphatic Polycarbonates Involving Oxetanes and Carbon Dioxide as Monomers

    E-Print Network [OSTI]

    Moncada, Adriana I.

    2011-08-08

    OF THE COPOLYMERIZATION REACTION OF OXETANE AND CARBON DIOXIDE TO PROVIDE ALIPHATIC POLYCARBONATES CATALYZED BY (SALEN)CrX COMPLEXES ............................................................... 27 Introduction... OF OXETANE OR EPOXIDES AND CO2 CATALYZED BY (SALEN)CrX COMPLEXES .............. 66 Introduction .................................................................................... 66 Experimental Section...

  9. Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance

    E-Print Network [OSTI]

    Whalen, Kristen Elizabeth

    2008-01-01

    Understanding how organisms deal with potentially toxic or fitness-reducing allelochemicals is important for understanding patterns of predation and herbivory in the marine environment. The ability of marine consumers to ...

  10. Bc Meson Formfactors and Bc-->PV Decays Involving Flavor Dependence of Transverse Quark Momentum

    E-Print Network [OSTI]

    Rohit Dhir; R. C. Verma

    2009-01-08

    We present a detailed analysis of the Bc form factors in the BSW framework, by investigating the effects of the flavor dependence on the average transverse quark momentum inside a meson. Branching ratios of two body decays of Bc meson to pseudoscalar and vector mesons are predicted.

  11. PERMITTING OF A PROJECT INVOLVING HYDROGEN: A CODE OFFICIALS PERSPECTIVE

    SciTech Connect (OSTI)

    Kallman, Richard A.; Barilo, Nick F.; Murphy, W. F.

    2012-05-11

    Recent growth in the development of hydrogen infrastructure has led to more requests for code officials to approve hydrogen-related projects and facilities. To help expedite the review and approval process, significant efforts have been made to educate code officials on permitting hydrogen vehicle fueling stations and facilities using stationary fuel cells (e.g., backup power for telephone cell tower sites). Despite these efforts, project delays continue because of several factors, including the limited experience of code officials with these types of facilities, submittals that lack the required information (including failure to adequately address local requirements), and submission of poor quality documents. The purpose of this paper is to help project proponents overcome these potential roadblocks and obtain timely approval for a project. A case study of an actual stationary application permitting request is provided to illustrate the value of addressing these issues.

  12. Search for doubly charged Higgs bosons with lepton-flavour-violating decays involving tau leptons

    SciTech Connect (OSTI)

    Aaltonen, T.

    2007-12-01

    The authors search for pair production of doubly charged Higgs particles (H{sup {+-}{+-}}) followed by decays into electron-tau (e{tau}) and muon-tau ({mu}{tau}) pairs using a data set corresponding to an integrated luminosity of 350 pb{sup -1} collected from {bar p}p collisions at {radical}s = 1.96 TeV by the CDF II experiment. They search separately for cases where three or four final-state leptons are detected, and then combine the results into limits for each exclusive flavor decay mode of the H{sup {+-}{+-}}. Assuming 100% branching ratios of the H{sup {+-}{+-}} to left-handed e{tau} ({mu}{tau}) pairs, they set an H{sup {+-}{+-}} lower mass limit of 114 (112) GeV/c{sup 2} at the 95% confidence level (C.L.).

  13. Directory of DOE and contractor personnel involved in non-government standards activities

    SciTech Connect (OSTI)

    NONE

    1995-08-01

    This document contains a listing of DOE employees and DOE contractors who have submitted form DOE F 1300.2, Record of Non-Government Standards Activity. Additional names were added from rosters supplied by non-Government standards bodies.

  14. A new development in microcomputer software for mine ventilation planning involving the installation of fans

    SciTech Connect (OSTI)

    O'Leary, M.S.J.; McPherson, M.J.

    1989-01-01

    This paper introduces a computer simulation that extends the use of microcomputer systems for mine ventilation planning. The program was developed as part of an ongoing study to produce a simulation model that would determine the optimum duties of a main fan and a booster fan without requiring the trial-and-error runs that are necessary with currently available programs. To use the new program, the user specifies the location of one main fan and one booster fan, and the minimum required airflows in any number of working places. The computer determines the fan duties that maintains the required airflows at the lowest operating costs without causing undesired recirculation. The methodology of the program and an example showing how it can be applied are presented.

  15. Pair correlations in nuclei involved in neutrinoless double beta decay: 76Ge and 76Se

    E-Print Network [OSTI]

    S. J. Freeman; J. P. Schiffer; A. C. C. Villari; J. A. Clark; C. Deibel; S. Gros; A. Heinz; D. Hirata; C. L. Jiang; B. P. Kay; A. Parikh; P. D. Parker; J. Qian; K. E. Rehm; X. D. Tang; V. Werner; C. Wrede

    2007-03-23

    Precision measurements were carried out to test the similarities between the ground states of 76Ge and 76Se. The extent to which these two nuclei can be characterized as consisting of correlated pairs of neutrons in a BCS-like ground state was studied. The pair removal (p,t) reaction was measured at the far forward angle of 3 degrees. The relative cross sections are consistent (at the 5% level) with the description of these nuclei in terms of a correlated pairing state outside the N=28 closed shells with no pairing vibrations. Data were also obtained for 74Ge and 78Se.

  16. Involvement in Early Childhood Special Education Among Chinese and Non-Chinese American Parents

    E-Print Network [OSTI]

    SooHoo, Tanya

    2012-01-01

    H. Brookes. Chiang, L. H. , & Hadadian, A. (2007). Chineseand Chinese-American families of children with disabilities.to developmental disabilities in Chinese American families.

  17. MEDIA COVERAGE INVOLVING MEMBERS OR AFFILIATES OF THE VISUALIZATION AND COMPUTER GRAPHICS RESEARCH GROUP FROM THE

    E-Print Network [OSTI]

    Hamann, Bernd

    ,'' Sacramento Business Journal, p. 6, Sacra mento, California, March 7, 2014, http://www.bizjournals.com/sacramentocontractsucdavisstart/. News story, ``Stratovan Lands Two TSA Contracts,'' Sacramento Business Journal, Sacramento, Califor nia, February 26, 2014, http://www.bizjournals.com/sacramento/news/2014/02/26/stratovan

  18. MEDIA COVERAGE INVOLVING MEMBERS OR AFFILIATES OF THE VISUALIZATION AND COMPUTER GRAPHICS RESEARCH GROUP FROM THE

    E-Print Network [OSTI]

    Hamann, Bernd

    ," Sacramento Business Journal, p. 6, Sacra- mento, California, March 7, 2014, http://www.bizjournals.com/sacramento-contracts-uc-davis-start/. News story, "Stratovan Lands Two TSA Contracts," Sacramento Business Journal, Sacramento, Califor- nia, February 26, 2014, http://www.bizjournals.com/sacramento/news/2014/02/26/stratovan

  19. Global shape processing involves a hierarchy of integration stages Jason Bell a,b,

    E-Print Network [OSTI]

    Kingdom, Frederick A. A.

    , McGill University, 687 Pine Av. West, H4-14, Montreal, Quebec, Canada H3A 1A1 b Dept. of Psychology, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium a r t i c l e i n f o Article history & Wilson, 2006, 2010). Traditionally, line drawings of objects have been used to deter- mine which parts

  20. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    E-Print Network [OSTI]

    Houseworth, Jim

    2014-01-01

    BBM Barcelona Basic Model CIEMAT Centro de Investigacionesdesign (Nater, 2012). 2) CIEMAT and UPC of Spain conductedmodel as applied by the CIEMAT and UPC (Garitte and Gens,

  1. March 2005 Page 1 of 2 CDCResearchInvolvingRadiationReleasesfromtheIdahoNational

    E-Print Network [OSTI]

    is the Idaho National Laboratory? The Idaho National Laboratory (INL) is on the upper Snake River Plain

  2. Machining dynamics and stability analysis in longitudinal turning involving workpiece whirling

    E-Print Network [OSTI]

    Dassanayake, Achala Viomy

    2009-06-02

    Tool chatter in longitudinal turning is addressed with a new perspective using a complex machining model describing the coupled tool-workpiece dynamics subject to nonlinear regenerative cutting forces, instantaneous depth-of-cut (DOC) and workpiece...

  3. Redox Characterization of Proteins Involved in the Mitochondrial Intermembrane Space Pathway

    E-Print Network [OSTI]

    Neal, Sonya Elina

    2013-01-01

    Bardwell. 1999. Oxidative protein folding is driven by thecatalyzes oxidative protein folding in mitochondria. Naturecarriers in oxidative protein folding. International journal

  4. Insulin signaling is involved in the regulation of worker division of labor in honey bee colonies

    E-Print Network [OSTI]

    Robinson, Gene E.

    of individuals. Nurse bees feed brood for the first 12 weeks of adult life, process and store food for another of individuals. Older bees acquire the colony's food by foraging for nectar and pollen, and the younger ``nurse expression in the brain and abdomen than did nurses, despite their low lipid stores. These differences

  5. Staying Competitive in the 90's: How to Make Public Involvement Work for Your Energy Project

    E-Print Network [OSTI]

    Loveless, K. W.

    1993-01-01

    with development plans and to stay competitive, they must have broad-based public support for their projects. Today few energy projects are stopped because they lack the technical capability to produce clean and affordable energy, but because they lack the public...

  6. Quick Facts Preparation for law school is a continuous process. It involves planning an

    E-Print Network [OSTI]

    Saldin, Dilano

    with the highest acceptance rates are physics, philosophy, biology, chemistry, and anthropology. Contact Us: Gwyn or business transactions. Traditionally, lawyers have found jobs in private practice, ranging from single

  7. Involvement in Early Childhood Special Education Among Chinese and Non-Chinese American Parents

    E-Print Network [OSTI]

    SooHoo, Tanya

    2012-01-01

    education to receive an education and services to meet theirtheir childrens education and services. Few studies haveabout my child's education and services. I attend support

  8. Propensity for Aggression and Associated Patterns of Youth Involvement: A Mixed-Methods Study

    E-Print Network [OSTI]

    Gendron, Brian Patrick

    2012-01-01

    n.d. ). What Would Make You Fight? Scale: A New Scale toat what point is it okay to fight back? 8. When is it okaydo you know when it is okay to fight and when it is not? 13.

  9. Sensory-Motor Systems of Copepods involved in their Escape from Suction Feeding

    E-Print Network [OSTI]

    the siphon. Calanus finmarchicus responded at an average threshold strain rate of 18.7/s, escaped at 0.46 m

  10. PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

    E-Print Network [OSTI]

    Peng, Qianqian; Zhao, Jinghua; Xue, Fuzhong

    2010-01-26

    confidence interval test (PCA-BCIT), which directly uses the PC scores to assess gene-disease association, was developed and evaluated for three ways of extracting PCs, i.e., cases only(CAES), controls only(COES) and cases and controls combined...

  11. Posters: Psychiatric Genetics, Neurogenetics and Neurodegeneration74 Copy number aberrations affecting adhesion genes involved in the

    E-Print Network [OSTI]

    Hochreiter, Sepp

    . For extracting ASD candidate genes, we developed an analysis pipeline for rare and small CNAs. Rare CNAs risk in 5-15% of cases in families with one affected individual. We performed array comparative genomic

  12. Controlling Drug Use and Crime Among California's Drug-Involved Offenderes: Testing, Sanctions, and Treatment

    E-Print Network [OSTI]

    Kleiman, Mark A. R.

    1998-01-01

    OFFENDERS: TESTING, SANCTIONS, AND TREATMENT Mark A.R.and thus grounds for sanctions, including revocation ofno individual power to sanction: they can only refer their

  13. Application of the SCALE TSUNAMI Tools for the Validation of Criticality Safety Calculations Involving 233U

    SciTech Connect (OSTI)

    Mueller, Don [ORNL; Rearden, Bradley T [ORNL; Hollenbach, Daniel F [ORNL

    2009-02-01

    The Radiochemical Development Facility at Oak Ridge National Laboratory has been storing solid materials containing 233U for decades. Preparations are under way to process these materials into a form that is inherently safe from a nuclear criticality safety perspective. This will be accomplished by down-blending the {sup 233}U materials with depleted or natural uranium. At the request of the U.S. Department of Energy, a study has been performed using the SCALE sensitivity and uncertainty analysis tools to demonstrate how these tools could be used to validate nuclear criticality safety calculations of selected process and storage configurations. ISOTEK nuclear criticality safety staff provided four models that are representative of the criticality safety calculations for which validation will be needed. The SCALE TSUNAMI-1D and TSUNAMI-3D sequences were used to generate energy-dependent k{sub eff} sensitivity profiles for each nuclide and reaction present in the four safety analysis models, also referred to as the applications, and in a large set of critical experiments. The SCALE TSUNAMI-IP module was used together with the sensitivity profiles and the cross-section uncertainty data contained in the SCALE covariance data files to propagate the cross-section uncertainties ({Delta}{sigma}/{sigma}) to k{sub eff} uncertainties ({Delta}k/k) for each application model. The SCALE TSUNAMI-IP module was also used to evaluate the similarity of each of the 672 critical experiments with each application. Results of the uncertainty analysis and similarity assessment are presented in this report. A total of 142 experiments were judged to be similar to application 1, and 68 experiments were judged to be similar to application 2. None of the 672 experiments were judged to be adequately similar to applications 3 and 4. Discussion of the uncertainty analysis and similarity assessment is provided for each of the four applications. Example upper subcritical limits (USLs) were generated for application 1 based on trending of the energy of average lethargy of neutrons causing fission, trending of the TSUNAMI similarity parameters, and use of data adjustment techniques.

  14. The Mechanisms Involved in Seed Dormancy Alleviation by Hydrogen Cyanide Unravel the Role of Reactive

    E-Print Network [OSTI]

    Leubner, Gerhard

    activation of NADPH oxidase. However, it is not related to lipid reserve degradation or gluconeogenesis

  15. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma

    SciTech Connect (OSTI)

    Dumanski, J.P.; Carlbom, E.; Collins, V.P.; Nordenskjoeld, M.

    1987-12-01

    The genotypes were analyzed at 11 polymorphic DNA loci (restriction fragment length alleles) on chromosome 22 in tumor and normal tissues from 35 unrelated patients with meningiomas. Sixteen tumors retained the constitutional genotype along chromosome 22, while 14 tumors (40%) showed loss of one constitutional allele at all informative loci, consistent with monosomy 22 in the tumor DNA. The remaining 5 tumors (14%) showed loss of heterozygosity in the tumor DNA at one or more chromosome 22 loci and retained heterozygosity at other loci, consistent with variable terminal deletions of one chromosome 22 in the tumor DNA. The results suggest that a meningioma locus is located distal to the myoglobin locus, within 22q12.3-qter. Multiple loci on their chromosomes also were studied, and 12 of the 19 tumors with losses of chromosome 22 alleles showed additional losses of heterozygosity at loci on one to three other chromosomes. All tumors that retained the constitutional genotype on chromosome 22 also retained heterozygosity at all informative loci on other chromosomes analyzed, suggesting that the rearrangement of chromosome 22 is a primary event in the tumorigenesis of meningioma.

  16. Creating New Leaders: Youth Involvement in Community Activism in South Africa

    E-Print Network [OSTI]

    Reed, Amber R

    2011-01-01

    and Nicolas Argenti. Young Africa: Realising the Rights ofand Youth. Trenton, NJ: Africa World Press, 2002. Debates ofSocial Imagination in Africa. Anthropological Quarterly.

  17. Global prevalence and distribution of genes and microorganisms involved in mercury methylation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Podar, Mircea; Gilmour, C C; Brandt, Craig C; Bullock, Allyson L; Brown, Steven D; Crable, Bryan R; Palumbo, Anthony Vito; Somenahally, Anil C; Elias, Dwayne A

    2015-01-01

    Mercury methylation produces the neurotoxic, highly bioaccumulative methylmercury (MeHg). Recent identification of the methylation genes (hgcAB) provides the foundation for broadly evaluating microbial Hg-methylation potential in nature without making explicit rate measurements. We queried hgcAB diversity and distribution in all available microbial metagenomes, encompassing most environments. The genes were found in nearly all anaerobic, but not in aerobic, environments including oxygenated layers of the open ocean. Critically, hgcAB was effectively absent in ~1500 human microbiomes, suggesting a low risk of endogenous MeHg production. New potential methylation habitats were identified, including invertebrate guts, thawing permafrost, coastal dead zones , soils, sediments,moreand extreme environments, suggesting multiple routes for MeHg entry into food webs. Several new taxonomic groups potentially capable of Hg-methylation emerged, including lineages having no cultured representatives. We begin to address long-standing evolutionary questions about Hg-methylation and ancient carbon fixation mechanisms while generating a new global view of Hg-methylation potential.less

  18. Differing Professional Opinions for Technical Issues Involving Environment, Safety and Health

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29

    The Order establishes the DOE Differing Professional Opinion process for employees to raise technical concerns related to environment, safety, and health which cannot be resolved using routine processes. Supersedes DOE P 442.1 and DOE M 442.1-1.

  19. Response and Notification Procedures for Data Breaches Involving Personally Identifiable Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-10-09

    This Notice concerns actions to address data breaches of personally identifiable information that is collected, processed or maintained by DOE. Extended by DOE N 251.73 until 1-9-09. No cancellation.

  20. Chemical Genetic Screen for AMPK?2 Substrates Uncovers a Network of Proteins Involved in Mitosis

    E-Print Network [OSTI]

    Banko, MaxR.

    The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use a chemical genetics screen ...

  1. Utility/Industry Partnerships Involving Distributed Generation Technologies in Evolving Electricity Markets

    E-Print Network [OSTI]

    Rastler, D. M.

    1997-01-01

    the defUlition given above. It can be a corporate strategic tool in the newly competitive electric business. It can be part of an offensive strategy to capture new retail markets. It can be used to optimize support of a capacity-stretched distribution... system. It can be used defensively to retain existing customers. Example strategies include: Meet existing customers' growing local peak demands without adding long-payback T&D upgrades and/or new central station generation investments. Serve new...

  2. Localization and activation of CaMKII delta isoforms and their involvement in heart failure

    E-Print Network [OSTI]

    Mishra, Shikha

    2010-01-01

    hypertrophy and heart failure ..CaMKII mediated hypertrophy and heart failure .. I.F.II.C. Preparation of heart tissue extract and cell lysate

  3. Physical Simulation of an Embedded Surface Mesh Involving Deformation and Fracture

    E-Print Network [OSTI]

    Clack, Billy

    2012-07-16

    Simulating virtual objects which can deform or break apart within their environments is now common in state-of-the-art virtual simulations such as video games or surgery simulations. Real-time performance requires a physical model which provides...

  4. Abstract--This paper addresses the problem of controlling wind energy conversion systems (WECS) which involve

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Abstract-- This paper addresses the problem of controlling wind energy conversion systems (WECS-inverter. The goal of control is to maximize wind energy extraction and this needs letting the wind turbine rotor wind energy extraction) only for one wind speed value depending on the considered value of turbine

  5. Differential Involvement of Hedgehog Signaling in Butterfly Wing and Eyespot Development

    E-Print Network [OSTI]

    Monteiro, Antnia

    of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any 1357 supplement to National Science Foundation (NSF) award IOB -0653399 to AM and XT was partly supported by NSF award IOS 1146933 to AM. The funders had no role in study design, data collection

  6. The Challenge of Democratization in Nigeria: Involvement or Alienation of the Military

    E-Print Network [OSTI]

    Amadife, Emmanuel N.

    1992-01-01

    71108. 20x.arry Diamond. "Nigeria in Search of Democracy,"Impending Demise of Nigeria's Forthcoming Third Republic,"system that has governed Nigeria for the most part since

  7. Application of Dissolution Dynamic Nuclear Polarization to the Characterization of Reactions Involving Large Molecules

    E-Print Network [OSTI]

    Lee, Youngbok

    2013-03-13

    by hyperpolarization of the nuclear spins. NMR signals of hyperpolarized samples are enhanced by several orders of magnitude. Dissolution Dynamic Nuclear Polarization (D-DNP) is a versatile technique capable of polarizing many different nuclei in the solid state...

  8. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

    DOE Patents [OSTI]

    Olopade, Olufunmilayo I.

    2007-03-20

    Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

  9. Involvement of right STS in audio-visual integration for affective speech

    E-Print Network [OSTI]

    Hagan, Cindy

    2012-03-28

    Hippocampus, L Thalamus, L Posterior Cingulate cortex - <.010 -2.73 4 -26 -2 R Thalamus, R Caudate, R Hippocampus, L Thalamus, L Posterior Cingulate cortex - <.015 -2.50 14 -10 18 L Thalamus, L Posterior Cingulate cortex, R Hippocampus, R Caudate, R Thalamus... - <.015 -2.42 -6 -20 18 L Inferior Frontal gyrus 45 <.020 -2.31 -56 24 8 Theta (4-8Hz) AV Unambiguous (A + V) 100-600ms R Thalamus, R Caudate, R Putamen, R Anterior Cingulate cortex - <.005 -3.01 4 -26 -2 R Caudate,R Putamen, R Thalamus, R...

  10. Participatory Action Research Involving Families from Underserved Communities and Researchers: Respecting Cultural and Linguistic Diversity

    E-Print Network [OSTI]

    Markey, Ursula; Santelli, Betsy; Turnbull, Ann P.

    1998-01-01

    G54G6FG70G69G63G3AG20G50G61G72G74G69G63G69G70G61G74G6FG72G79G20G41G63G74G69G6FG6EG20G52G65G73G65G61G72G63G68G20G28G50G41G52G29 G42G4FG54G54G4FG4DG20G20G4CG49G4EG45 G54G49G50G53 G4DG61G72G6BG65G79G2CG20G55G2EG2CG20G53G61G6EG74G65G6CG6CG69G2CG20G42G2...EG2CG20G26G20G54G75G72G6EG62G75G6CG6CG2CG20G41G2EG50G2EG20G28G31G39G39G38G29G2EG20G20G50G61G72G74G69G63G69G70G61G74G6FG72G79G20G61G63G74G69G6FG6EG20G72G65G73G65G61G72G63G68G20G69G6EG76G6FG6CG76G69G6EG67G20G66G61G6DG69G6CG69G65G73G20G66G72G6FG6D G75G6...

  11. The "visual word form area" is involved in successful memory encoding of both words and faces

    E-Print Network [OSTI]

    Mei, L; Xue, G; Chen, C; Xue, F; Zhang, M; Dong, Q

    2010-01-01

    and learning of visual word forms. For instance, severalencoding of both familiar words (Otten et al. , 2001, 2002;to learn novel visual word forms (Chen et al. , 2007; Dong

  12. Abstract--Understanding human motor control involves studying the principles used to optimize dynamic movement.

    E-Print Network [OSTI]

    was scaled based on body segment mass-center locations [15] to match the anthropometry of the subject. Figure

  13. Community health programs in many developing countries are very similar: most involve semi-

    E-Print Network [OSTI]

    Rosenfeld, Roni

    communities in a large hierarchically managed sys- tem across the country. In Pakistan, recent evalua- tions to current information access mechanisms such as handbooks and manuals. We will be designing, developing to such populations, in a way that is both sustainable and appropri- ate [Mansell, 1998 & Tongia, 2005

  14. Power-law distributions in events involving nuclear and radiological materials

    E-Print Network [OSTI]

    Chow, Jijun

    2009-01-01

    Nuclear and radiological events are large-impact, hard-to-predict rare events, whose associated probability is exceedingly low. They can exert monumental impacts and lead to grave environmental and economic consequences. ...

  15. A Complex Containing PGRL1 and PGR5 Is Involved in the Switch between Linear

    E-Print Network [OSTI]

    , Universita` del Piemonte Orientale, `Amedeo Avogadro', Corso Borsalino 54, 15100 Alessandria, Italy

  16. United States military involvement and the armed forces in the Dominican Republic, 1916 to 1966

    E-Print Network [OSTI]

    Jimenez, Luis Augusto

    1981-01-01

    . TABLE OF CONTENTS ABSTRACT ACKNOWLEDGEMENTS DEDICATION TABLE OF CONTENTS LIST OF FIGURES LIST OF TABLES CHAPTER Page vi vii I. INTRODUCTION II. HISTORICAL REVIEW The Initial Contacts: 1844 to 1915 United States Occupation: 1916 to 1930... government was established in the Dominican Republic (Fuller and Cosmas, 1974), and in 1966 the country was again controlled by United States troops, following a civil war (Gutierrez, 1972). The historical period limited by these two events has been...

  17. Effects of Parent Expectations and Involvement on the School Readiness of Children in Head Start

    E-Print Network [OSTI]

    Cook, Krystal Tisha'

    2010-10-12

    There is an achievement gap occurring between ethnic minority children, mostly from low-income homes, and European American children in the United States. The gap between these children is present at school entry. Many ...

  18. THREE-DIMENSIONAL STRUCTURE OF THE LITHOSTATHINE PROTOFIBRIL, A PROTEIN INVOLVED IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    interactions into a tetramer. Each tetramer then linked up with another tetramer as the result of longitudinal

  19. May/June 2011 MAQS & Respirators Bee-ing Involved Counting Frames of Bees

    E-Print Network [OSTI]

    Ishida, Yuko

    , neoprene, or nitrile), and protective eyewear. Wear a respirator with an organic-vapor removing cartridge), or a NIOSH approved respirator with an organic vapor (OV) cartridge or canister with any N, R, P or HE

  20. Examining the Economic Implications and Considerations for Continued Involvement in the Conservation Reserve Program in Texas

    E-Print Network [OSTI]

    Schuchard, Laura Mae

    2012-10-19

    The Conservation Reserve Program (CRP) has become increasingly important in Texas due to the high level of program participation, particularly in the high plains of Texas. There is also a seemingly large amount of CRP contracts that will expire...