Sample records for interstitial therapy view

  1. Synchrotron Radiation Therapy from a Medical Physics point of view

    SciTech Connect (OSTI)

    Prezado, Y.; Berkvens, P.; Braeuer-Krisch, E.; Renier, M.; Bravin, A. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Adam, J. F. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Centre Hospitalier Universitaire, B.P. 217, Grenoble Cedex 9, F-38043 (France); Martinez-Rovira, I. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Institut de Tecniques Energetiques, Universitat Politecnica de Catalunya, Diagonal 647, E-08028 Barcelona (Spain); Fois, G. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Dipartimento di Fisica, Universita degli Studi di Cagliari, Strada Provinciale Monserrato Sestu km 0.700, Monserrato, Cagliari 09042 (Italy); Thengumpallil, S. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Dipartimento di Fisica E. Amaldi, Universita degli Studi Roma Tre, 84 Via della Vasca Navale, 00146 Roma (Italy); Edouard, M.; Deman, P. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Vautrin, M. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); DOSIsoft, Cachan (France)

    2010-07-23T23:59:59.000Z

    Synchrotron radiation (SR) therapy is a promising alternative to treat brain tumors, whose management is limited due to the high morbidity of the surrounding healthy tissues. Several approaches are being explored by using SR at the European Synchrotron Radiation Facility (ESRF), where three techniques are under development Synchrotron Stereotactic Radiation Therapy (SSRT), Microbeam Radiation Therapy (MRT) and Minibeam Radiation Therapy (MBRT).The sucess of the preclinical studies on SSRT and MRT has paved the way to clinical trials currently in preparation at the ESRF. With this aim, different dosimetric aspects from both theoretical and experimental points of view have been assessed. In particular, the definition of safe irradiation protocols, the beam energy providing the best balance between tumor treatment and healthy tissue sparing in MRT and MBRT, the special dosimetric considerations for small field dosimetry, etc will be described. In addition, for the clinical trials, the definition of appropiate dosimetry protocols for patients according to the well established European Medical Physics recommendations will be discussed. Finally, the state of the art of the MBRT technical developments at the ESRF will be presented. In 2006 A. Dilmanian and collaborators proposed the use of thicker microbeams (0.36-0.68 mm). This new type of radiotherapy is the most recently implemented technique at the ESRF and it has been called MBRT. The main advantage of MBRT with respect to MRT is that it does not require high dose rates. Therefore it can be more easily applied and extended outside synchrotron sources in the future.

  2. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01T23:59:59.000Z

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  3. Most Viewed Documents for Biology and Medicine: September 2014...

    Office of Scientific and Technical Information (OSTI)

    32 Dose and volume specification for reporting interstitial therapy NONE (1997) 28 Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey;...

  4. Di-interstitial defect in silicon revisited

    SciTech Connect (OSTI)

    Londos, C. A.; Antonaras, G. [Solid State Section, Physics Department, University of Athens, Panepistimiopolis, Zografos, 157 84 Athens (Greece)] [Solid State Section, Physics Department, University of Athens, Panepistimiopolis, Zografos, 157 84 Athens (Greece); Chroneos, A. [Engineering and Innovation, The Open University, Milton Keynes MK7 6AA (United Kingdom) [Engineering and Innovation, The Open University, Milton Keynes MK7 6AA (United Kingdom); Department of Materials, Imperial College London, London SW7 2BP (United Kingdom)

    2013-11-21T23:59:59.000Z

    Infrared spectroscopy was used to study the defect spectrum of Cz-Si samples following fast neutron irradiation. We mainly focus on the band at 533 cm{sup ?1}, which disappears from the spectra at ?170 °C, exhibiting similar thermal stability with the Si-P6 electron paramagnetic resonance (EPR) spectrum previously correlated with the di-interstitial defect. The suggested structural model of this defect comprises of two self-interstitial atoms located symmetrically around a lattice site Si atom. The band anneals out following a first-order kinetics with an activation energy of 0.88 ± 0.3 eV. This value does not deviate considerably from previously quoted experimental and theoretical values for the di-interstitial defect. The present results indicate that the 533 cm{sup ?1} IR band originates from the same structure as that of the Si-P6 EPR spectrum.

  5. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  6. Integration of microvascular, interstitial, and lymphatic function to determine the effect of their interaction on interstitial fluid volume

    E-Print Network [OSTI]

    Dongaonkar, Ranjeet Manohar

    2009-05-15T23:59:59.000Z

    , three specific aims were achieved. 1) Develop a simple, transparent, and general algebraic approach that predicts interstitial fluid pressure, volume and protein concentration resulting from the interaction of microvascular, interstitial and lymphatic...

  7. Interstitial Fe in MgO

    SciTech Connect (OSTI)

    Mølholt, T. E., E-mail: tem4@hi.is; Gislason, H. P.; Ólafsson, S. [Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavík (Iceland); Mantovan, R. [Laboratorio MDM, IMM-CNR, Via Olivetti 2, 20846 Agrate Brianza (MB) (Italy); Gunnlaugsson, H. P.; Svane, A.; Weyer, G. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Masenda, H.; Naidoo, D. [School of Physics, University of the Witwatersrand, WITS 2050 (South Africa); Bharuth-Ram, K. [Durban University of Technology, Durban 4001 (South Africa); Fanciulli, M. [Laboratorio MDM, IMM-CNR, Via Olivetti 2, 20846 Agrate Brianza (MB) (Italy); Dipartimento di Scienza dei Materiali, Università di Milano Bicocca, Milano (Italy); Johnston, K. [PH Department, ISOLDE/CERN, 1211 Geneva 23 (Switzerland); Langouche, G. [Instituut voor Kern-en Stralings fysika, University of Leuven, B-3001 Leuven (Belgium); Sielemann, R. [Helmholtz-Zentrum-Berlin für Materialien und Energie, D-14109 Berlin (Germany)

    2014-01-14T23:59:59.000Z

    Isolated {sup 57}Fe atoms were studied in MgO single-crystals by emission Mössbauer spectroscopy following implantation of {sup 57}Mn decaying to {sup 57}Fe. Four Mössbauer spectral components were found corresponding to different Fe lattice positions and/or charge states. Two components represent Fe atoms substituting Mg as Fe{sup 2+} and Fe{sup 3+}, respectively; a third component is due to Fe in a strongly implantation-induced disturbed region. The fourth component, which is the focus of this paper, can be assigned to Fe at an interstitial site. Comparison of its measured isomer shift with ab initio calculations suggests that the interstitial Fe is located on, or close to, the face of the rock-salt MgO structure. To harmonize such an assignment with the measured near-zero quadrupole interaction a local motion process (cage motion) of the Fe has to be stipulated. The relation of such a local motion as a starting point for long range diffusion is discussed.

  8. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  9. E-Print Network 3.0 - acute interstitial nephritis Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with a possible diagnosis of acute interstitial nephritis in patients treated... of infusion techniques with low-dose bupivacaine and an Interstitial nephritis associated with...

  10. Effects of interstitial flow on tumor cell migration

    E-Print Network [OSTI]

    Polacheck, William J. (William Joseph)

    2010-01-01T23:59:59.000Z

    Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial ...

  11. Microdefects and self-interstitial diffusion in crystalline silicon

    SciTech Connect (OSTI)

    Knowlton, W.B.

    1998-05-01T23:59:59.000Z

    In this thesis, a study is presented of D-defects and self-interstitial diffusion in silicon using Li ion (Li{sup +}) drifting in an electric field and transmission electron microscopy (TEM). Obstruction of Li{sup +} drifting has been found in wafers from certain but not all FZ p-type Si. Incomplete Li{sup +} drifting always occurs in the central region of the wafers. This work established that interstitial oxygen is not responsible for hindering Li{sup +} drifting. TEM was performed on a samples from the partially Li{sup +} drifted area and compared to regions without D-defects. Precipitates were found only in the region containing D-defects that had partially Li{sup +} drifted. This result indicates D-defects are responsible for the precipitation that halts the Li{sup +} drift process. Nitrogen (N) doping has been shown to eliminate D-defects as measured by conventional techniques. Li{sup +} drifting and D-defects provide a useful means to study Si self-interstitial diffusion. The process modeling program SUPREM-IV was used to simulate the results of Si self-interstitial diffusion obtained from Li{sup +} drifting experiments. Anomalous results from the Si self-interstitial diffusion experiments forced a re-examination of the possibility of thermal dissociation of D-defects. Thermal annealing experiments that were performed support this possibility. A review of the current literature illustrates the need for more research on the effects of thermal processing on FZ Si to understand the dissolution kinetics of D-defects.

  12. Phase I, study of a miniature X-ray source for interstitial radiotherapy of brain metastases

    SciTech Connect (OSTI)

    Douglas, R.M.; Beatty, J.; Biggs, P. [Massachusetts General Hospital, Boston, MA (United States)] [and others] [Massachusetts General Hospital, Boston, MA (United States); and others

    1995-12-31T23:59:59.000Z

    Despite a variety of stereotactic techniques used to increase intracranical local control, dose escalation strategies remain controversial, with respect to therapeutric gain, convenience, and cost effectiveness, in the setting of brain metastases. In this report, we summarize our experience with the safety and efficacy of a new miniature X-ray device for interstitial radiosurgical treatment of intracranial metastatic neoplasms. Although the role of surgical resection of solitary metastases is established, aggressive treatment with proton, gamma knife, and linac radiation therapy for these lesions is under investigation. The new miniature X-ray device offers a very localized, convenient, time and cost efficient means of delivering radiotherapy to these lesions, with lower normal tissue exposure than gamma knife or proton beam techniques. Retreatment of previously irradiated areas are also now under investigation as part of a Phase II trial. The photon radiosurgery system is a miniature battery operated 40 kV x-ray device designed by the Photoelectron Corporation for use in the interstitial treatment of small tumors ({ge}3 cm in diameter) in humans. This 10 cm long, low current, high voltage X-ray generator is easily mounted in a stereotactic frame and produces low energy (10-20 KeV) x-rays to be emitted from the 10 cm long, 3.2 mm diameter probe, after stereotactic insertion into the tumor. Two scintillation detectors positioned on the stereotactic frame near the patient`s scalp monitor radiation. The spherical X-ray beam behaves essentially as a point source, with dose rate nominally 150 cGy/min. at a distance of 10mm, for a beam current of 40 {mu}A and a voltage of 40 kv.

  13. Atomistic Study of the Migration of Di- and Tri-Interstitials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    silicon is performed using classical molecular dynamics simulations with a Stillinger-Weber potential. At first the structures and energetics of the di- and the tri-interstitial...

  14. Stability and Migration of Charged Oxygen Interstitials in ThO2...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    oxygen interstitial mobility in ThO2 than in CeO2. Citation: Xiao HY, Y Zhang, and WJ Weber.2013."Stability and Migration of Charged Oxygen Interstitials in ThO2 and CeO2."Acta...

  15. Exchange of deeply trapped and interstitial hydrogen in silicon Blair Tuttle

    E-Print Network [OSTI]

    Adams, James B

    Exchange of deeply trapped and interstitial hydrogen in silicon Blair Tuttle Department of Physics Engineering, Arizona State University, Tempe, Arizona 85287-6006 Received 22 May 1998; revised manuscript mechanisms between an interstitial hydrogen atom and a deeply bound H at a silicon-hydrogen bond. We

  16. Hydrogen and chloride ions effects on the automobile interstitial-free steel corrosion

    E-Print Network [OSTI]

    Volinsky, Alex A.

    1 Hydrogen and chloride ions effects on the automobile interstitial-free steel corrosion L.Q. Guo 1 , D. Liang 1 , Y. Bai 1 , X.L. Miao 2 , L.J. Qiao 1 , Alex A. Volinsky 3 1 Corrosion and Protection Abstract The effects of hydrogen and chloride ions on the corrosion behavior of interstitial-free steel

  17. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  18. Relation between thermal expansion and interstitial formation energy in pure Fe and Cr

    E-Print Network [OSTI]

    Relation between thermal expansion and interstitial formation energy in pure Fe and Cr Janne potentials give lower interstitial formation energy, but predict too small thermal expansion. We also show University, Uppsala, Sweden Abstract By fitting a potential of modified Finnis­Sinclair type to the thermal

  19. JOURNAL DE PHYSIQUE Colloque C7, supplkment au no 12, Tome 38, dkcembre 1977,page C7-221 ORDERED AND DISORDERED HYDROGEN INTERSTITIAL$ IN NIOBIUM,

    E-Print Network [OSTI]

    Boyer, Edmond

    AND DISORDERED HYDROGEN INTERSTITIAL$ IN NIOBIUM, TANTALUM AND VANADIUM CRYSTALS : STRUCTURES AND PHASE DIAGRAMS

  20. A theoretical analysis of interstitial hydrogen : pressure-composition-temperature, chemical potential, enthalpy and entropy

    E-Print Network [OSTI]

    Orondo, Peter Omondi

    2012-01-01T23:59:59.000Z

    We provide a first principles analysis of the physics and thermodynamics of interstitial hydrogen in metal. By utilizing recent advances in Density Functional Theory (DFT) to get state energies of the metal-hydrogen system, ...

  1. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  2. Urban temporal storage : re-thinking the public domain using interstitial space in NYC

    E-Print Network [OSTI]

    Uchida, Mio

    2010-01-01T23:59:59.000Z

    This thesis aims to rethink the notion of public space and civic duty in the city. By using interstitial, underused spaces, without disputing present urban and legal status, the thesis wants to accomodate services for the ...

  3. Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector

    E-Print Network [OSTI]

    Chang, Jean H

    2014-01-01T23:59:59.000Z

    Interstitial fluid (ISF) provides information on a patient's health as it contains regulatory molecules that are correlated with disease-related processes. However, current ISF acquisition techniques can be slow, resulting ...

  4. Machine therapy

    E-Print Network [OSTI]

    Dobson, Kelly E. (Kelly Elizabeth), 1970-

    2007-01-01T23:59:59.000Z

    Machine Therapy is a new practice combining art, design, psychoanalysis, and engineering work in ways that access and reveal the vital, though often unnoticed, relevance of people's interactions and relationships with ...

  5. Prarie View RDF

    Energy Savers [EERE]

    PRAIRIE VIEW RDF 2 Prairie View RDF Located at JAAP (approx. 40 miles southwest of Chicago), 223 acres on 455 Acre Parcel Will County Owner; Waste Management, Operator ...

  6. Nano Vacancy Clusters and Trap Limited Diffusion of Si Interstitials in Silicon

    SciTech Connect (OSTI)

    Prof. Wei-Kan Chu

    2010-05-05T23:59:59.000Z

    The objective of this project is to develop a method to characterize nano vacancy clusters and the dynamics of their formation in ion-irradiated silicon. It will impact (1) semiconductor device processing involving ion implantation, and (2) device design concerning irradiation hardness in harsh environments. It also aims to enhance minority participation in research and curricula on emerging materials and ion beam science. Vacancy defects are of scientific and technological importance since they are ubiquitous when the host materials are exposed to particle irradiation. Studies on vacancy clustering in the past decades were mainly theoretical and the approach heavily relied on the total-energy calculation methods. The lack of experimental data is mainly due to the formidable task in measuring the cluster size and density using modern metrological techniques, including transmission electron microscopy and positron annihilation spectroscopy. To surmount these challenges, we proposed a novel approach to tackle the metrological problems on the nano vacancy clusters, especially in determining densities and sizes of the nano vacancies based on the premise that the vacancy-clusters act as diffusion-trapping centers. For a silicon substrate containing vacancyclusters, the diffusion of interstitials (from the surface) can be classified into three phases: (1) an ultrafast phase-I in which the trapping centers have little effect on the diffusion of interstitials; (2) a prolonged phase-II in which the loss rate of interstitials by trapping balances the influx of interstitials from the surface; and (3) a phase-III diffusion in which surface influx of interstitials depletes the trapping centers and interstitials consequently propagate deeper into the bulk. By measuring diffusion profiles of Si interstitials as a function of diffusion time, void sizes and void densities can be obtained through fitting. Experimentally, our approach to characterize voids is realized through three consecutive steps. (a) First, high energy self ion irradiation is used to create a wide vacancy-rich region, and to form voids by post implantation annealing. (b) In an additional annealing step in oxygen ambient, Si interstitials are injected in by surface oxidation. (c) Analyzing trap-limited diffusion of Si interstitials, which is experimentally detectable by studying the diffusion of multiple boron superlattices grown in Si, and enables us to characterize the nano voids, e.g. their sizes and densities.

  7. Mechanism for the reduction of interstitial supersaturations in MeV-implanted silicon

    SciTech Connect (OSTI)

    Venezia, V.C. [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States)] [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States); Haynes, T.E. [Solid State Division, Oak Ridge National Laboratory, MS-6048, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States)] [Solid State Division, Oak Ridge National Laboratory, MS-6048, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States); Agarwal, A. [Semiconductor Equipment Operations, Eaton Corporation, 55 Cherry Hill Drive, Beverly, Massachusetts 01915 (United States)] [Semiconductor Equipment Operations, Eaton Corporation, 55 Cherry Hill Drive, Beverly, Massachusetts 01915 (United States); Pelaz, L.; Gossmann, H.; Jacobson, D.C.; Eaglesham, D.J. [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States)] [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States)

    1999-03-01T23:59:59.000Z

    We demonstrate that the excess vacancies induced by a 1 MeV Si implant reduce the excess interstitials generated by a 40 keV Si implant during thermal annealing when these two implants are superimposed in silicon. It is shown that this previously observed reduction is dominated by vacancy annihilation and not by gettering to deeper interstitial-type extended defects. Interstitial supersaturations were measured using B doping superlattices (DSL) grown on a silicon-on-insulator (SOI) substrate. Implanting MeV and keV Si ions into the B DSL/SOI structure eliminated the B transient enhanced diffusion normally associated with the keV implant. The buried SiO{sub 2} layer in the SOI substrate isolates the deep interstitials-type extended defects of the MeV implant, thereby eliminating the possibility that these defects getter the interstitial excess induced by the keV Si implant. {copyright} {ital 1999 American Institute of Physics.}

  8. Influence of interstitial Mn on magnetism in room-temperature ferromagnet Mn(1+delta)Sb

    SciTech Connect (OSTI)

    Taylor, Alice E [ORNL; Berlijn, Tom [ORNL; Hahn, Steven E [ORNL; May, Andrew F [ORNL; Williams, Travis J [ORNL; Poudel, Lekhanath N [ORNL; Calder, Stuart A [ORNL; Fishman, Randy Scott [ORNL; Stone, Matthew B [ORNL; Aczel, Adam A [ORNL; Cao, Huibo [ORNL; Lumsden, Mark D [ORNL; Christianson, Andrew D [ORNL

    2015-01-01T23:59:59.000Z

    We report elastic and inelastic neutron scattering measurements of the high-TC ferromagnet Mn(1+delta)Sb. Measurements were performed on a large, TC = 434 K, single crystal with interstitial Mn content of delta=0.13. The neutron diffraction results reveal that the interstitial Mn has a magnetic moment, and that it is aligned antiparallel to the main Mn moment. We perform density functional theory calculations including the interstitial Mn, and find the interstitial to be magnetic in agreement with the diffraction data. The inelastic neutron scattering measurements reveal two features in the magnetic dynamics: i) a spin-wave-like dispersion emanating from ferromagnetic Bragg positions (H K 2n), and ii) a broad, non-dispersive signal centered at forbidden Bragg positions (H K 2n+1). The inelastic spectrum cannot be modeled by simple linear spin-wave theory calculations, and appears to be significantly altered by the presence of the interstitial Mn ions. The results show that the influence of the int

  9. Surface-induced charge at the Ge (001) surface and its interaction with self-interstitials

    SciTech Connect (OSTI)

    Kamiyama, Eiji; Sueoka, Koji [Department of Communication Engineering, Okayama Prefectural University, 111 Kuboki, Soja-shi, Okayama-ken 719-1197 (Japan); Vanhellemont, Jan [Department of Solid State Sciences, Ghent University, B-9000 Gent (Belgium)

    2014-02-21T23:59:59.000Z

    The Ge (001) surface with dimer structure, is negatively charged while into the bulk, positive charges are observed even deeper than the fifteenth layer from the surface. This is different from the Si case. This charge distribution can lead to the repulsion of positively charged self-interstitials by the positively charged near surface layer in an implantation or irradiation process. Self-interstitial reflection by Ge surfaces had been proposed to explain the results of diffusion experiments during irradiation whereby positively charged self-interstitials are generated by collisions of highly energetic particles with Ge atoms. We investigated different Ge (001) surface comparing an as-cleaved surface with dangling bonds to a surface with dimer structure, and to a surface terminated by hydrogen atoms. The effect of these different surface terminations on the surface-induced charges in the near surface bulk were calculated by ab initio techniques.

  10. Estimation of isodose curves in radiation therapy and related response analysis

    E-Print Network [OSTI]

    Goodlett, James Campbell

    1967-01-01T23:59:59.000Z

    by a review of literature and the second by a computer program. Accompanying the literature review is a bibliography of interstitial and intracavitary radiation therapy dealing with radium and radon sources with emphasis on references dealing...- 2 active seed (usually radon or gold-198) could be made the proper strength to destroy only the tumor when placed in the center of the tumor, However, tumors are rarely or never truly spheroid and, in addition, economic considerations dictate...

  11. EVOLUTION OF SELF-INTERSTITIALS INDUCED BY ION-IMPLANTATION IN SiGe ALLOYS

    E-Print Network [OSTI]

    Florida, University of

    EVOLUTION OF SELF-INTERSTITIALS INDUCED BY ION-IMPLANTATION IN SiGe ALLOYS By ROBERT T. CROSBY and Astronomy at the University of Aarhus in Denmark provided the utmost quality SiGe structures for my {311 great colleague, supervisor, and friend) grew the B-doped SiGe structures. J. Liu of Varian

  12. Characterization of the nitrogen split interstitial defect in wurtzite aluminum nitride using density functional theory

    SciTech Connect (OSTI)

    Szállás, A., E-mail: szallas.attila@wigner.mta.hu [Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, P.O. Box 49, H-1525 Budapest (Hungary); Szász, K. [Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, P.O. Box 49, H-1525 Budapest (Hungary); Institute of Physics, Eötvös University, Pázmány Péter sétány 1/A, H-1117 Budapest (Hungary); Trinh, X. T.; Son, N. T.; Janzén, E. [Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping (Sweden); Gali, A., E-mail: gali.adam@wigner.mta.hu [Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, P.O. Box 49, H-1525 Budapest (Hungary); Department of Atomic Physics, Budapest University of Technology and Economics, Budafoki út 8, H-1111 Budapest (Hungary)

    2014-09-21T23:59:59.000Z

    We carried out Heyd-Scuseria-Ernzerhof hybrid density functional theory plane wave supercell calculations in wurtzite aluminum nitride in order to characterize the geometry, formation energies, transition levels, and hyperfine tensors of the nitrogen split interstitial defect. The calculated hyperfine tensors may provide useful fingerprint of this defect for electron paramagnetic resonance measurement.

  13. Structure and high-temperature properties of Ti{sub 5}Si{sub 3} with interstitial additions

    SciTech Connect (OSTI)

    Williams, Jason

    1999-12-01T23:59:59.000Z

    This study was motivated by the fact that previous research on the structure and properties of Ti{sub 5}Si{sub 3} showed unacceptably inconsistent results. The primary reason for these inconsistencies was interstitial contamination of Ti{sub 5}Si{sub 3} by carbon, nitrogen and oxygen. Thus, this study measured the effects that these interstitial atoms have on some of the previously reported properties. These properties include crystalline structure, thermal expansion anisotropy, electronic structure and bonding, and high temperature oxidation resistance. In Chapter 2 of this study, the lattice parameters and atomic positions of Ti{sub 5}Si{sub 3} as a function of carbon, nitrogen or oxygen content were measured via x-ray and neutron diffraction. Comparing these lattice parameters to those reported in other studies on supposedly pure Ti{sub 5}Si{sub 3} confirmed that the majority of the previous studies had samples with a considerable amount of interstitial impurities. In fact, the lattice parameter trends given in Chapter 2 can be used to estimate the types and level of impurities in these studies. Furthermore, Chapter 2 discusses how atomic positions change as interstitial atoms are incorporated into the lattice. These changes in atomic separations suggest that strong bonds form between the interstitial atoms and the surrounding titanium atoms. This is in full agreement with the electronic structure calculations given in Chapter 4. These calculations show that bonding does occur between titanium d-states and interstitial atom p-states at the expense of bonding between some of the titanium and silicon atoms. In addition, carbon seems to be the most strongly bonded interstitial atom. Knowledge of the exact interstitial content and its effect on bonding is important because Chapters 3 and 5 have shown that interstitial atoms have a marked effect on the thermal expansion and oxidation resistance. As discussed in Chapter 3, all interstitial atoms lower the thermal expansion anisotropy of Ti{sub 5}Si{sub 3} due to the formation of bonds between the interstitial atom and the surrounding titanium atoms. Although interstitial atoms do have an effect on the thermal expansion of Ti{sub 5}Si{sub 3}, these effects were not strong enough to explain all the scatter of previous studies. These studies most likely suffered from systematic errors as a result of poor experimental design. The experimental procedure used in this study was designed to significantly reduce these systematic errors.

  14. World Views From fragmentation

    E-Print Network [OSTI]

    .......................................................11 2. The Seven Components of a World View...................................................... 20 3. The Unity of the Seven Sub........................................... 25 5. The Purpose of the group `Worldviews

  15. Natural History of Clinically Staged Low- and Intermediate-Risk Prostate Cancer Treated With Monotherapeutic Permanent Interstitial Brachytherapy

    SciTech Connect (OSTI)

    Taira, Al V. [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.or [Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, WV (United States); Galbreath, Robert W. [Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, WV (United States); Wallner, Kent E. [Puget Sound Healthcare Corporation, Group Health Cooperative, University of Washington, Seattle, WA (United States); Butler, Wayne M. [Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, WV (United States)

    2010-02-01T23:59:59.000Z

    Purpose: To evaluate the natural history of clinically staged low- and intermediate-risk prostate cancer treated with permanent interstitial seed implants as monotherapy. Methods and Materials: Between April 1995 and May 2005, 463 patients with clinically localized prostate cancer underwent brachytherapy as the sole definitive treatment. Men who received supplemental external beam radiotherapy or androgen deprivation therapy were excluded. Dosimetric implant quality was determined based on the minimum dose that covered 90% of the target volume and the volume of the prostate gland receiving 100% of the prescribed dose. Multiple parameters were evaluated as predictors of treatment outcomes. Results: The 12-year biochemical progression-free survival (bPFS), cause-specific survival, and overall survival rates for the entire cohort were 97.1%, 99.7%, and 75.4%, respectively. Only pretreatment prostate-specific antigen level, percent positive biopsy cores, and minimum dose that covered 90% of the target volume were significant predictors of biochemical recurrence. The bPFS, cause-specific survival, and overall survival rates were 97.4%, 99.6%, and 76.2%, respectively, for low-risk patients and 96.4%, 100%, and 74.0%, respectively, for intermediate-risk patients. The bPFS rate was 98.8% for low-risk patients with high-quality implants versus 92.1% for those with less adequate implants (p < 0.01), and it was 98.3% for intermediate-risk patients with high-quality implants versus 86.4% for those with less adequate implants (p < 0.01). Conclusions: High-quality brachytherapy implants as monotherapy can provide excellent outcomes for men with clinically staged low- and intermediate-risk prostate cancer. For these men, a high-quality implant can achieve results comparable to high-quality surgery in the most favorable pathologically staged patient subgroups.

  16. NEWS & VIEWS Glass dynamics

    E-Print Network [OSTI]

    Weeks, Eric R.

    NEWS & VIEWS Glass dynamics Diverging views on glass transition Gregory B. mc.mckenna@ttu.edu T he glass transition is one of the most intriguing phenomena in the world of soft condensed matter. Despite decades of study, many aspects of the behaviour of glass-forming liquids remain elusive

  17. Yield enhancement of reconfigurable microfluidics-based biochips using interstitial redundancy

    E-Print Network [OSTI]

    Fei Su; Krishnendu Chakrabarty

    2006-01-01T23:59:59.000Z

    Microfluidics-based biochips for biochemical analysis are currently receiving much attention. They automate highly repetitive laboratory procedures by replacing cumbersome equipment with miniaturized and integrated systems. As these microfluidics-based microsystems become more complex, manufacturing yield will have significant influence on production volume and product cost. We propose an interstitial redundancy approach to enhance the yield of biochips that are based on droplet-based digital microfluidics. In this design method, spare cells are placed in the interstitial sites within the microfluidic array, and they replace neighboring faulty cells via local reconfiguration. The proposed design method is evaluated using a set of concurrent real-life bioassays. The defect-tolerant design approach based on space redundancy and local reconfiguration is expected to facilitate yield enhancement of microfluidics-based biochips, especially for the emerging marketplace.

  18. Solving the Puzzle of ? 100 ? Interstitial Loop Formation in bcc Iron

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xu, Haixuan; Stoller, Roger E.; Osetsky, Yury N.; Terentyev, Dmitry

    2013-06-01T23:59:59.000Z

    The interstitial loop is a unique signature of radiation damage in structural materials for nuclear and other advanced energy systems. Unlike other bcc metals, two types of interstitial loops, 1/2?111? and ?100?, are formed in bcc iron and its alloys. However, the mechanism by which ?100? interstitial dislocation loops are formed has remained undetermined since they were first observed more than fifty years ago. We describe our atomistic simulations that have provided the first direct observation of ?100? loop formation. The process was initially observed using our self-evolving atomistic kinetic Monte Carlo method, and subsequently confirmed using molecular dynamics simulations. Formation of ?100? loops involves a distinctly atomistic interaction between two 1/2?111? loops, and does not follow the conventional assumption of dislocation theory, which is Burgers vector conservation between the reactants and the product. The process observed is different from all previously proposed mechanisms. Thus, our observations might provide a direct link between experiments and simulations and new insights into defect formation that may provide a basis to increase the radiation resistance of these strategic materials.

  19. Synthesis and characterization of substitutional and interstitial nitrogen-doped titanium dioxides with visible light photocatalytic activity

    SciTech Connect (OSTI)

    Peng Feng [School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640 (China)], E-mail: cefpeng@scut.edu.cn; Cai Lingfeng; Yu Hao; Wang Hongjuan; Yang Jian [School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640 (China)

    2008-01-15T23:59:59.000Z

    Both substitutional and interstitial nitrogen-doped titanium dioxides (N-TiO{sub 2}) were prepared. Their surface states were clarified by XPS spectra of N 1s, O 1s and Ti 2p. The results of photocatalysis show that both substitutional and interstitial N impurities greatly enhance the photoactivity of TiO{sub 2} in visible light. Moreover, the visible light activity of interstitial N-doped TiO{sub 2} is higher than that of substitutional N-doped TiO{sub 2}. The microwave synthesis presented in this paper is a promising and practical method to produce interstitial nitrogen-doped photocatalysts with high visible light activity. - Graphical abstract: Both substitutional and interstitial N impurities can enhance the photoactivity of TiO{sub 2} in visible light; moreover, the visible light activity of interstitial N-doped TiO{sub 2} is higher than that of substitutional N-doped TiO{sub 2}.

  20. Migration and Directional Change of Interstitial Clusters in ?-Fe: Searching for Transition States by the Dimer Method

    SciTech Connect (OSTI)

    Gao, Fei; Heinisch, Howard L.; Kurtz, Richard J.; Osetsky, Yuri N.; Hoagland, Richard G.

    2005-02-01T23:59:59.000Z

    The interstitial clusters produced by cascades in metals have very high mobility and exhibit thermally activated, one-dimensional glide along the crowdion direction, as revealed by molecular dynamics (MD) simulations. Only small interstitial clusters (<4) are observed to change their glide direction during the period of MD simulations ({approx} 10 ns), but the directional change for larger clusters is inaccessible to MD due to the limited time-scale. In order to overcome the ''time barrier'' in MD simulations, the dimer method is employed to search for possible transition states of interstitials and small interstitial clusters in alpha-Fe. The method uses only the first derivatives of the potential energy to find saddle points without knowledge of the final state of the transition. The possible transition states are studied as a function of interstitial cluster size, and the lowest energy barriers correspond to defect migration along (111) directions, as seen in MD simulations. Small clusters change their direction by a (110) fragment mechanism involving rotation of each crowdion into and out of the (110) dumbbell configuration, whereas the directional change for larger clusters is a two-step process consisting of translation along a <100> direction and rotation into an equivalent (111) direction. The mechanism of changing direction for a tri-interstitial cluster is also investigated using MD simulations.

  1. NEWS AND VIEWS PERSPECTIVE

    E-Print Network [OSTI]

    Mahler, D. Luke

    NEWS AND VIEWS PERSPECTIVE Niche diversification follows key innovation in Antarctic fish radiation Oxford Street, Cambridge MA 02138, USA Antarctic notothenioid fishes provide a fascinating evolu- tionary diversification has occurred repeatedly and in parallel. Keywords: community ecology, fish, macroevolution, phylo

  2. Forward viewing OCT endomicroscopy

    E-Print Network [OSTI]

    Liang, Kaicheng

    2014-01-01T23:59:59.000Z

    A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 ...

  3. Engineering Aerial view of

    E-Print Network [OSTI]

    Yang, Junfeng

    -neutral Torus 2 Climate Change 4 Combustion and Catalysis Laboratory #12;4 5 1Engineering Revolution 5 #12;6 7Columbia Engineering Plus #12;1 1 2 3 4 5 6 Aerial view of Columbia campus with Columbia Engineering-a liated buildings highlighted in blue Columbia Engineering Plus Engineering Revolution 4

  4. Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts

    SciTech Connect (OSTI)

    Chao, Louis Kuoping [Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan (China); Chang, W.-T.; Shih, Y.-W. [Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan (China); Huang, J.-S., E-mail: jaushyang12@hotmail.co [Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan (China)

    2010-04-15T23:59:59.000Z

    Cinnamaldehyde is a major and a bioactive compound isolated from the leaves of Cinnamomum osmophloeum kaneh. To explore whether cinnamaldehyde was linked to altered high glucose (HG)-mediated renal tubulointerstitial fibrosis in diabetic nephropathy (DN), the molecular mechanisms of cinnamaldehyde responsible for inhibition of HG-induced hypertrophy in renal interstitial fibroblasts were examined. We found that cinnamaldehyde caused inhibition of HG-induced cellular mitogenesis rather than cell death by either necrosis or apoptosis. There were no changes in caspase 3 activity, cleaved poly(ADP-ribose) polymerase (PARP) protein expression, and mitochondrial cytochrome c release in HG or cinnamaldehyde treatments in these cells. HG-induced extracellular signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK) (but not the Janus kinase 2/signal transducers and activators of transcription) activation was markedly blocked by cinnamaldehyde. The ability of cinnamaldehyde to inhibit HG-induced hypertrophy was verified by the observation that it significantly decreased cell size, cellular hypertrophy index, and protein levels of collagen IV, fibronectin, and alpha-smooth muscle actin (alpha-SMA). The results obtained in this study suggest that cinnamaldehyde treatment of renal interstitial fibroblasts that have been stimulated by HG reduces their ability to proliferate and hypertrophy through mechanisms that may be dependent on inactivation of the ERK/JNK/p38 MAPK pathway.

  5. Interstitial defects in silicon from 1{endash}5 keV Si{sup +} ion implantation

    SciTech Connect (OSTI)

    Agarwal, A.; Haynes, T.E. [Oak Ridge National Laboratory, MS-6048, Oak Ridge, Tennessee 37831 (United States)] [Oak Ridge National Laboratory, MS-6048, Oak Ridge, Tennessee 37831 (United States); Eaglesham, D.J.; Gossmann, H.; Jacobson, D.C.; Poate, J.M. [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States)] [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States); Erokhin, Y.E. [Eaton Corporation, 108 Cherry Hill Drive, Beverly, Massachusetts 01915 (United States)] [Eaton Corporation, 108 Cherry Hill Drive, Beverly, Massachusetts 01915 (United States)

    1997-06-01T23:59:59.000Z

    Extended defects from 5-, 2-, and 1-keV Si{sup +} ion implantation are investigated by transmission electron microscopy using implantation doses of 1 and 3{times}10{sup 14}cm{sup {minus}2} and annealing temperatures from 750 to 900{degree}C. Despite the proximity of the surface, {l_brace}311{r_brace}-type defects are observed even for 1 keV. Samples with a peak concentration of excess interstitials exceeding {approximately}1{percent} of the atomic density also contain some {l_brace}311{r_brace} defects which are corrugated across their width. These so-called zig-zag {l_brace}311{r_brace} defects are more stable than the ordinary {l_brace}311{r_brace} defects, having a dissolution rate at 750{degree}C which is ten times smaller. Due to their enhanced stability, the zig-zag {l_brace}311{r_brace} defects grow to lengths that are many times longer than their distance from the surface. It is proposed that zig-zag {l_brace}311{r_brace} defects form during the early stages of annealing by coalescence the high volume density of {l_brace}311{r_brace} defects confined within a very narrow implanted layer. These findings indicate that defect formation and dissolution will continue to control the interstitial supersaturation from ion implantation down to very low energies. {copyright} {ital 1997 American Institute of Physics.}

  6. Effect of interstitials on tensile strength and creep in nanostructured Ni

    SciTech Connect (OSTI)

    Yin, W.M. [Department of Mechanical Engineering, Polytechnic University, Six Metrotech Center, Brooklyn, NY 11201 (United States); Whang, S.H. [Department of Mechanical Engineering, Polytechnic University, Six Metrotech Center, Brooklyn, NY 11201 (United States)]. E-mail: swhang@poly.edu; Mirshams, R.A. [Department of Engineering Technology, University of North Texas, Denton, TX 76203-0679 (United States)

    2005-01-10T23:59:59.000Z

    The tensile, creep and anelastic behavior of nanostructured nickel doped and un-doped with boron was investigated. Specimen material with an average grain size of around 30 nm produced by the pulse electrodeposition method contains impurities such as carbon, sulfur and boron. The interstitials content does not have notable impact on the tensile strength at room temperature and 373 K. But, at 473 K, the minor change in sulfur content from 0.03 to 0.061 at.% raises the ultimate strength by 150 MPa while the boron doping further improves the tensile strength. On the other hand, with increasing sulfur content in nanostructured Ni, the ductility decreases. All the specimens exhibit significant anelastic relaxation from room temperature to 473 K. The creep test results show that both minimum creep rate and creep strain significantly decrease with increasing sulfur or by doping boron in nanostructured nickel. The stress exponent in the expression of Coble-type creep increases to around five at 373 and 473 K from two at room temperature. A model for grain boundary sliding, in which grain boundary dislocations and back stress are introduced, has successfully explained the large stress exponents. The calculated back stress indicates that the interstitials in grain boundaries effectively retard the sliding of grain boundary dislocations.

  7. Stereoscopic optical viewing system

    DOE Patents [OSTI]

    Tallman, Clifford S. (Walnut Creek, CA)

    1987-01-01T23:59:59.000Z

    An improved optical system which provides the operator a stereoscopic viewing field and depth of vision, particularly suitable for use in various machines such as electron or laser beam welding and drilling machines. The system features two separate but independently controlled optical viewing assemblies from the eyepiece to a spot directly above the working surface. Each optical assembly comprises a combination of eye pieces, turning prisms, telephoto lenses for providing magnification, achromatic imaging relay lenses and final stage pentagonal turning prisms. Adjustment for variations in distance from the turning prisms to the workpiece, necessitated by varying part sizes and configurations and by the operator's visual accuity, is provided separately for each optical assembly by means of separate manual controls at the operator console or within easy reach of the operator.

  8. Stereoscopic optical viewing system

    DOE Patents [OSTI]

    Tallman, C.S.

    1986-05-02T23:59:59.000Z

    An improved optical system which provides the operator with a stereoscopic viewing field and depth of vision, particularly suitable for use in various machines such as electron or laser beam welding and drilling machines. The system features two separate but independently controlled optical viewing assemblies from the eyepiece to a spot directly above the working surface. Each optical assembly comprises a combination of eye pieces, turning prisms, telephoto lenses for providing magnification, achromatic imaging relay lenses and final stage pentagonal turning prisms. Adjustment for variations in distance from the turning prisms to the workpiece, necessitated by varying part sizes and configurations and by the operator's visual accuity, is provided separately for each optical assembly by means of separate manual controls at the operator console or within easy reach of the operator.

  9. Workshop on neutron capture therapy

    SciTech Connect (OSTI)

    Fairchild, R.G.; Bond, V.P. (eds.)

    1986-01-01T23:59:59.000Z

    Potentially optimal conditions for Neutron Capture Therapy (NCT) may soon be in hand due to the anticipated development of band-pass filtered beams relatively free of fast neutron contaminations, and of broadly applicable biomolecules for boron transport such as porphyrins and monoclonal antibodies. Consequently, a number of groups in the US are now devoting their efforts to exploring NCT for clinical application. The purpose of this Workshop was to bring these groups together to exchange views on significant problems of mutual interest, and to assure a unified and effective approach to the solutions. Several areas of preclinical investigation were deemed to be necessary before it would be possible to initiate clinical studies. As neither the monomer nor the dimer of sulfhydryl boron hydride is unequivocally preferable at this time, studies on both compounds should be continued until one is proven superior.

  10. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ma, Jie; Yang, Jihui; Da Silva, J. L.F.; Wei, Su-Huai

    2014-10-01T23:59:59.000Z

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect statemore »is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.« less

  11. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ma, Jie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Yang, Jihui [National Renewable Energy Lab. (NREL), Golden, CO (United States); Da Silva, J. L.F. [Univ. of Sao Paulo, Sao Carlos (Brazil). Sao Carlos Institute of Chemistry; Wei, Su-Huai [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-10-01T23:59:59.000Z

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect state is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.

  12. Multi-view kernel construction

    E-Print Network [OSTI]

    Sa, Virginia R.; Gallagher, Patrick W.; Lewis, Joshua M.; Malave, Vicente L.

    2010-01-01T23:59:59.000Z

    5157-z Multi-view kernel construction Virginia R. de Sa ·multiple different graph construction algorithms. The Ng et

  13. TotalView Training

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesisAppliances » Top InnovativeTopoisomeraseTotalView

  14. Quality Assurance of Multifractionated Pelvic Interstitial Brachytherapy for Postoperative Recurrences of Cervical Cancers: A Prospective Study

    SciTech Connect (OSTI)

    Shukla, Pragya [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India); Chopra, Supriya, E-mail: schopra@actrec.gov.in [Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra (India); Engineer, Reena; Mahantshetty, Umesh [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India); Paul, Siji Nojin; Phurailatpam, Reena [Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra (India); SV, Jamema; Shrivastava, Shyam K. [Department of Radiation Oncology and Medical Physics, Tata Memorial Hospital, Tata Memorial Centre, Mumbai, Maharashtra (India)

    2012-03-15T23:59:59.000Z

    Purpose: To evaluate three-dimensional needle displacements during multifractionated interstitial brachytherapy (BT) for cervical cancers. Methods and Materials: Patients scheduled to undergo pelvic interstitial BT for postoperative and or postradiation vault recurrences were included from November 2009 to December 2010. All procedures were performed under spinal anesthesia. Postprocedure BT planning CT scans were obtained with patients in supine position with arms on the chest (interslice thickness of 3 mm). Thereafter, verification CT was repeated at every alternate fraction. Needle displacements were measured in reference to a relocatable bony point. The mean cranial, caudal, anteroposterior, and mediolateral displacements were recorded. Statistical significance of mean interfraction displacements was evaluated with Wilcoxon Test. Results: Twenty patients were included. Seventeen received boost BT (20 Gy/5 fractions/3 days) after external radiation, three received radical BT alone (36 Gy/9 fractions/5-8 days). An average of three scans (range, 2-3) were available per patient, and 357 needle displacements were analyzed. For the entire study cohort, the average of mean needle displacement was 2.5 mm (range, 0-7.4), 17.4 mm (range, 0-27.9), 1.7 mm (range, 0-6.7), 2.1 mm (range, 0-9.5), 1.7 mm (range, 0-9.3), and 0.6 mm (range, 0-7.8) in cranial, caudal, anterior, posterior, right, and left directions, respectively. The mean displacement in the caudal direction was higher between Days 1 and 2 than that between Days 2 and 3 (13.4 mm vs. 3.8 mm; p = 0.01). The average caudal displacements were no different between reirradiation and boost cohort (15.2 vs. 17.8 mm). Conclusions: Clinically significant caudal displacements occur during multifractionated pelvic brachytherapy. Optimal margins need to be incorporated while preplanning brachytherapy to account for interfraction displacements.

  15. Protective laser beam viewing device

    DOE Patents [OSTI]

    Neil, George R.; Jordan, Kevin Carl

    2012-12-18T23:59:59.000Z

    A protective laser beam viewing system or device including a camera selectively sensitive to laser light wavelengths and a viewing screen receiving images from the laser sensitive camera. According to a preferred embodiment of the invention, the camera is worn on the head of the user or incorporated into a goggle-type viewing display so that it is always aimed at the area of viewing interest to the user and the viewing screen is incorporated into a video display worn as goggles over the eyes of the user.

  16. False color viewing device

    DOE Patents [OSTI]

    Kronberg, J.W.

    1991-05-08T23:59:59.000Z

    This invention consists of a viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching, the user`s eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage.

  17. False color viewing device

    DOE Patents [OSTI]

    Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

    1992-01-01T23:59:59.000Z

    A viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching the user's eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage.

  18. False color viewing device

    DOE Patents [OSTI]

    Kronberg, J.W.

    1992-10-20T23:59:59.000Z

    A viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching the user's eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage. 7 figs.

  19. The view from Kiev

    SciTech Connect (OSTI)

    Kiselyov, S.

    1993-11-01T23:59:59.000Z

    This article reports the observations of correspondents for the Bulletin (two Russian journalists, one based in Moscow, the other in Kiev) who investigated the status of the Soviet Union's Black Sea Fleet and Ukraine's status as a non-nuclear-weapons state. After two years of wrangling and two earlier failed settlements, Russian President Boris Yeltsin met with Ukrainian President Leonid Kravchuk at Massandra in Crimea. On September 3, the leaders announced that Russia would buy out Ukraine's interest in the fleet and lease the port at Sevastopol. The Massandra summit was also supposed to settle Ukraine's status as a non-nuclear-weapons state. Described here are the Kiev-based correspondent's views on the Massandra summit (and its major topics), which was to have been called off by the Russian foreign ministry when Ukrainian Prime Minister Leonid Kuchma resigned.

  20. GROUP THERAPY Syracuse University

    E-Print Network [OSTI]

    McConnell, Terry

    your individual needs. In a group, up to eight students meet with one or two group therapists. MostGROUP THERAPY Syracuse University Counseling Center 200 Walnut Place Phone: 315-443-4715 Fax: 315-443-4276 counselingcenter.syr.edu WHAT STUDENTS SAY ABOUT GROUP THERAPY I was really anxious about joining a group

  1. High-Risk Prostate Cancer With Gleason Score 8-10 and PSA Level {<=}15 ng/ mL Treated With Permanent Interstitial Brachytherapy

    SciTech Connect (OSTI)

    Fang, L. Christine [Department of Radiation Oncology, University of Washington, Seattle, WA (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Butler, Wayne M.; Galbreath, Robert W.; Murray, Brian C.; Reed, Joshua L. [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, WV (United States); Wallner, Kent E. [Puget Sound Veterans Affairs Hospital, Seattle, WA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: With widespread prostate-specific antigen (PSA) screening, there has been an increase in men diagnosed with high-risk prostate cancer defined by a Gleason score (GS) {>=}8 coupled with a relatively low PSA level. The optimal management of these patients has not been defined. Cause-specific survival (CSS), biochemical progression-free survival (bPFS), and overall survival (OS) were evaluated in brachytherapy patients with a GS {>=}8 and a PSA level {<=}15 ng/mL with or without androgen-deprivation therapy (ADT). Methods and Materials: From April 1995 to October 2005, 174 patients with GS {>=}8 and a PSA level {<=}15 ng/mL underwent permanent interstitial brachytherapy. Of the patients, 159 (91%) received supplemental external beam radiation, and 113 (64.9%) received ADT. The median follow-up was 6.6 years. The median postimplant Day 0 minimum percentage of the dose covering 90% of the target volume was 121.1% of prescription dose. Biochemical control was defined as a PSA level {<=}0.40 ng/mL after nadir. Multiple parameters were evaluated for impact on survival. Results: Ten-year outcomes for patients without and with ADT were 95.2% and 92.5%, respectively, for CSS (p = 0.562); 86.5% and 92.6%, respectively, for bPFS (p = 0.204); and 75.2% and 66.0%, respectively, for OS (p = 0.179). The median post-treatment PSA level for biochemically controlled patients was <0.02 ng/mL. Multivariate analysis failed to identify any predictors for CSS, whereas bPFS and OS were most closely related to patient age. Conclusions: Patients with GS {>=}8 and PSA level {<=}15 ng/mL have excellent bPFS and CSS after brachytherapy with supplemental external beam radiotherapy. The use of ADT did not significantly impact bPFS, CSS, or OS.

  2. A molecular loop with interstitial channels in a chiral environment and study of formation of metal-metal bonds in dinickel, dipalladium and dititanium complexes

    E-Print Network [OSTI]

    Ibragimov, Sergey

    2006-08-16T23:59:59.000Z

    This dissertation consists of two independent topics: (1) a molecular loop with interstitial channels in a chiral environment; (2) study of formation of metal-metal bonds in dinickel, dipalladium and dititanium complexes On the first topic, a study...

  3. A molecular loop with interstitial channels in a chiral environment and study of formation of metal-metal bonds in dinickel, dipalladium and dititanium complexes 

    E-Print Network [OSTI]

    Ibragimov, Sergey

    2006-08-16T23:59:59.000Z

    This dissertation consists of two independent topics: (1) a molecular loop with interstitial channels in a chiral environment; (2) study of formation of metal-metal bonds in dinickel, dipalladium and dititanium complexes On ...

  4. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow

    SciTech Connect (OSTI)

    Semino, Carlos E. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States)]. E-mail: semino@mit.edu; Kamm, Roger D. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States); Lauffenburger, Douglas A. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States)

    2006-02-01T23:59:59.000Z

    We show here that autocrine ligand activation of epidermal growth factor (EGF) receptor in combination with interstitial flow is critically involved in the morphogenetic response of endothelial cells to VEGF stimulation. Human umbilical vein endothelial cell (HUVEC) monolayers cultured on a collagen gel and exposed to low interstitial flow in the absence of EGF and VEGF remained viable and mitotic but exhibited little evidence of vascular morphogenesis. Addition of VEGF produced a flow-dependent morphogenetic response within 48 to 72 h, characterized by branched capillary-like structures. The response was substantially abolished by inhibitors related to the autocrine EGF receptor pathway including Galardin, AG1478, PD98059, and an EGF receptor-blocking antibody, indicating that regulation of the morphogenetic process operates via autocrine EGF receptor activation. Moreover, we observed that in our system the EGF receptor was always activated independently of the interstitial flow, and, in addition, the EGF receptor inhibitors used above reduced the phosphorylation state of the receptor, correlating with inhibition of capillary morphogenesis. Finally, 5'bromo-2'-deoxyuridine (BrdU) labeling identified dividing cells at the monolayer but not in the extending capillary-like structures. EGF pathway inhibitors Galardin and AG1478 did not reduce BrdU incorporation in the monolayer, indicating that the EGF-receptor-mediated morphogenetic behavior is mainly due to cell migration rather than proliferation. Based on these results, we propose a two-step model for in vitro capillary morphogenesis in response to VEGF stimulation with interstitial fluid flow: monolayer maintenance by mitotic activity independent of EGF receptors and a migratory response mediated by autocrine EGF receptor activation wherein cells establish capillary-like structures.

  5. Long-Term Outcome for Clinically Localized Prostate Cancer Treated With Permanent Interstitial Brachytherapy

    SciTech Connect (OSTI)

    Taira, Al V. [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.or [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States); Butler, Wayne M.; Galbreath, Robert W.; Lief, Jonathan [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, West Virginia (United States); Wallner, Kent E. [Puget Sound Healthcare Corporation, Group Health Cooperative, University of Washington, Seattle, Washington (United States)

    2011-04-01T23:59:59.000Z

    Purpose: To present the largest series of prostate cancer brachytherapy patients treated with modern brachytherapy techniques and postimplant day 0 dosimetric evaluation. Methods and Materials: Between April 1995 and July 2006, 1,656 consecutive patients were treated with permanent interstitial brachytherapy. Risk group stratification was carried out according to the Mt. Sinai guidelines. Median follow-up was 7.0 years. The median day 0 minimum dose covering at least 90% of the target volume was 118.8% of the prescription dose. Cause of death was determined for each deceased patient. Multiple clinical, treatment, and dosimetric parameters were evaluated for impact on the evaluated survival parameters. Results: At 12 years, biochemical progression-free survival (bPFS), cause-specific survival (CSS), and overall survival (OS) for the entire cohort was 95.6%, 98.2%, and 72.6%, respectively. For low-, intermediate-, and high-risk patients, bPFS was 98.6%, 96.5%, and 90.5%; CSS was 99.8%, 99.3%, and 95.2%; and OS was 77.5%, 71.1%, and 69.2%, respectively. For biochemically controlled patients, the median posttreatment prostate-specific antigen (PSA) concentration was 0.02 ng/ml. bPFS was most closely related to percent positive biopsy specimens and risk group, while Gleason score was the strongest predictor of CSS. OS was best predicted by patient age, hypertension, diabetes, and tobacco use. At 12 years, biochemical failure and cause-specific mortality were 1.8% and 0.2%, 5.1% and 2.1%, and 10.4% and 7.1% for Gleason scores 5 to 6 and 7 and {>=}8, respectively. Conclusions: Excellent long-term outcomes are achievable with high-quality brachytherapy for low-, intermediate-, and high-risk patients. These results compare favorably to alternative treatment modalities including radical prostatectomy.

  6. Analysis of Interstitial Elements in Niobium with Secondary Ion Mass Spectrometry (SIMS)

    SciTech Connect (OSTI)

    Maheshwari, P.; Griffis, D. P. [Analytical Instrumentation Facility, North Carolina State University, Raleigh, NC 27607 (United States); Materials Science and Engineering, North Carolina State University, Raleigh, NC 27607 (United States); Stevie, F. A. [Analytical Instrumentation Facility, North Carolina State University, Raleigh, NC 27607 (United States); Myeneni, G.; Ciovati, G. [Jefferson Laboratory, Newport News, VA 23606 (United States); Rigsbee, J. M. [Materials Science and Engineering, North Carolina State University, Raleigh, NC 27607 (United States)

    2011-03-31T23:59:59.000Z

    Superconducting Radio Frequency (SRF) cavities provide enhanced efficiency and reduced energy utilization in present day particle accelerators. Niobium (Nb) is the material of choice for these cavities due to its high critical temperature and critical magnetic field. In order to understand why certain treatments, especially a low temperature bake, improve performance, it is important to study Nb surface characteristics and identify elemental contamination that can affect the performance of the cavity. H, C, O, and N are of interest because they are interstitial impurities in Nb. In earlier work, SIMS analysis using a CAMECA IMS-6F with Cs{sup +} primary beam showed that C and N were probably not significant factors impacting performance but there was a very high level of H in the Nb. Ion implants of C, N, O, and D into Nb provided quantification of C, N, O and indicated that D is very mobile in the Nb. Further analyses showed that heat treated Nb has lower levels of surface H than non heat treated Nb and subsequent removal of surface oxide by etching causes intake of H in a heat treated Nb sample. This result helps confirm the role of surface oxide as a hydrogen barrier. To further understand the oxide, Nb samples were anodized to obtain a thicker surface oxide and H and D were implanted into this oxide to check for the appearance of implant peaks. SIMS depth profile analyses were carried out and confirmed the presence of the implant shape for these elements in the oxide. Relative Sensitivity Factor (RSFs) could then be calculated for quantification of H in the oxide. Since the Nb matrix signal showed little change from the oxide to the substrate, the same RSF was used to estimate the H concentration in the Nb at 2x10{sup 22} atoms/cm{sup 3}(approximately 40% mole fraction H).

  7. A Regulator's View of Cogeneration

    E-Print Network [OSTI]

    Shanaman, S. M.

    1982-01-01T23:59:59.000Z

    of the total national electric generation. In view of the energy requirements of Pennsylvania's industry and the impact of increasing energy costs on employment the Commission directed its technical staff to investigate the potential for industrial cogeneration...

  8. Enzyme replacement therapy for Pompe disease

    E-Print Network [OSTI]

    Burris, Ryan Jonathan William

    2010-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

  9. Viewing device for electron-beam equipment

    SciTech Connect (OSTI)

    Nasyrov, R.S.

    1985-06-01T23:59:59.000Z

    Viewing devices are used to observe melting, welding, and so on in vacuum systems, an it is necessary to protect the windows from droplets and vapor. A viewing device for electron-beam equipment is described in which the viewing tube and mounting flange are made as a tubular ball joint enclosed in a steel bellows, which render the viewing device flexible. Bending the viewing tube in the intervals between observations protects the viewing window from sputtering and from drops of molten metal.

  10. Targeted Therapies for Acute Leukemia

    E-Print Network [OSTI]

    Aldana Masangkay, Grace Idalia

    2013-01-01T23:59:59.000Z

    therapy of pediatric acute leukemias: an update. J. Clin.binding protein in acute leukemia. Blood 2002; 99(7):2617–therapy of pediatric acute leukemias: an update. J. Clin.

  11. Wide field of view telescope

    DOE Patents [OSTI]

    Ackermann, Mark R. (Albuquerque, NM); McGraw, John T. (Placitas, NM); Zimmer, Peter C. (Albuquerque, NM)

    2008-01-15T23:59:59.000Z

    A wide field of view telescope having two concave and two convex reflective surfaces, each with an aspheric surface contour, has a flat focal plane array. Each of the primary, secondary, tertiary, and quaternary reflective surfaces are rotationally symmetric about the optical axis. The combination of the reflective surfaces results in a wide field of view in the range of approximately 3.8.degree. to approximately 6.5.degree.. The length of the telescope along the optical axis is approximately equal to or less than the diameter of the largest of the reflective surfaces.

  12. VOLUME 84, NUMBER 3 P H Y S I C A L R E V I E W L E T T E R S 17 JANUARY 2000 Stability of Si-Interstitial Defects: From Point to Extended Defects

    E-Print Network [OSTI]

    Wilkins, John

    . Khan2 1 Department of Physics, Ohio State University, Columbus, Ohio 43210 2 Department of Electrical Engineering, Ohio State University, Columbus, Ohio 43210 (Received 7 September 1999) Trends in the growth-formation energy on the number of interstitials and interstitial chains, together with the anisotropy

  13. Input a journal Viewing Journals

    E-Print Network [OSTI]

    Sussex, University of

    Journals Contents: Input a journal Viewing Journals Deleting a journal Entering jnl into different period Problems Input a journal 1 Login to Bluqube 2 Select 3 Enter relevant Doc type To select the number of journals you will processing & the total credit value 6 Click on 7 Enter brief description 8

  14. View

    E-Print Network [OSTI]

    2006-02-28T23:59:59.000Z

    Feb 28, 2006 ... For defining the NSO functions composing the battery, we consider two categories: – randomly generated functions, either defined as the ...

  15. View

    E-Print Network [OSTI]

    2008-07-07T23:59:59.000Z

    a battery of benchmark instances of up to 200 nodes are reported. These seem to be the largest instances that have been solved exactly for this problem.

  16. View

    E-Print Network [OSTI]

    2011-06-21T23:59:59.000Z

    May 14, 2010 ... Generally, even testing whether a matrix is in C? is co-NP-complete [23]. ...... One concrete example is the following: ?. ?. ?. ?. ?. ?. 1 1/3 1/3 ...

  17. View

    E-Print Network [OSTI]

    2013-10-14T23:59:59.000Z

    based on median finding, variable fixing, and secant techniques. Keywords: ..... arithmetic operations, the overall complexity is O(n2). D. The worst case bound in ..... always work on its rated clock speed, we turned force the Linux system to use the ..... dimensionally equidistributed uniform pseudo-random number generator.

  18. View

    E-Print Network [OSTI]

    1910-31-00T23:59:59.000Z

    Sep 3, 2003 ... Landau (TDGL) equation, the Maxwell equations, and an energy equation ... varying currents and magnetic fields generate thermal energy, ...

  19. View

    E-Print Network [OSTI]

    2013-11-05T23:59:59.000Z

    Approach. ?. Selin Damla Ahipasao?glu the date of receipt and acceptance should be .... which has the minimum volume is a natural choice from both theoretical and ... This problem has important applications in statistics and solving this prob- ...... the SDPT3 algorithm using the CVX platform on MATLAB, which is a classic.

  20. View

    E-Print Network [OSTI]

    2010-08-12T23:59:59.000Z

    all real solutions of a given system of polynomial equations. ... A crucial ingredient is a semidefinite characterization of the real radical ideal ...... The options.

  1. View

    E-Print Network [OSTI]

    2004-12-25T23:59:59.000Z

    Let fbe a meromorphic function satisfying condition (1.2), and let rj be a sequence with property (2.5). Then the set S is finite and for some subsequence of ...

  2. View

    E-Print Network [OSTI]

    2010-07-30T23:59:59.000Z

    project of the classification of (simple) nuclear separable C*-algebras [E]. Let C? denote the category of separable C*-algebras and ?-homomorphisms.

  3. View

    E-Print Network [OSTI]

    2006-07-11T23:59:59.000Z

    the classification results of Kirchberg and Phillips using the notion of nuclear absorbing ... A simple purely infinite nuclear separable C*-algebra is called.

  4. View

    E-Print Network [OSTI]

    2008-12-16T23:59:59.000Z

    The aim of this paper is to give a survey of some basic theory of semi-infinite programming. .... operations of addition and multiplication by a scalar. We associate ...

  5. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. [University of Alberta, Department of Surgery (Canada)], E-mail: rmoore@cha.ab.ca; Xiao, Zhengwen [University of Alberta, Cross Cancer Institute, Department of Oncology (Canada); Owen, Richard J.; Ashforth, Robert [University of Alberta, Department of Radiology and Diagnostic Imaging (Canada); Dickey, Dwayne [University of Alberta, Department of Electric Engineering (Canada); Helps, Cathy [Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada); Tulip, John [University of Alberta, Department of Electric Engineering (Canada)

    2008-01-15T23:59:59.000Z

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  6. Distant Metastases Following Permanent Interstitial Brachytherapy for Patients With Clinically Localized Prostate Cancer

    SciTech Connect (OSTI)

    Taira, Al V. [Western Radiation Oncology, Mountain View, California (United States); Merrick, Gregory S., E-mail: gmerrick@urologicresearchinstitute.org [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States); Galbreath, Robert W.; Butler, Wayne M.; Lief, Jonathan [Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, West Virginia (United States); Adamovich, Edward [Department of Pathology, Wheeling Hospital, Wheeling, West Virginia (United States); Wallner, Kent E. [Puget Sound Healthcare Corporation, Group Health Cooperative, University of Washington, Seattle, Washington (United States)

    2012-02-01T23:59:59.000Z

    Purpose: Recent publications have suggested high-risk patients undergoing radical prostatectomy have a lower risk of distant metastases and improved cause-specific survival (CSS) than patients receiving definitive external beam radiation therapy (XRT). To date, none of these studies has compared distant metastases and CSS in brachytherapy patients. In this study, we evaluate such parameters in a consecutive cohort of brachytherapy patients. Methods and Materials: From April 1995 to June 2007, 1,840 consecutive patients with clinically localized prostate cancer were treated with brachytherapy. Risk groups were stratified according to National Comprehensive Cancer Network ( (www.nccn.org)) guidelines. Subgroups of 658, 893, and 289 patients were assigned to low, intermediate, and high-risk categories. Median follow-up was 7.2 years. Along with brachytherapy implantation, 901 (49.0%) patients received supplemental XRT, and 670 (36.4%) patients received androgen deprivation therapy (median duration, 4 months). The mode of failure (biochemical, local, or distant) was determined for each patient for whom therapy failed. Cause of death was determined for each deceased patient. Multiple parameters were evaluated for impact on outcome. Results: For the entire cohort, metastases-free survival (MFS) and CSS at 12 years were 98.1% and 98.2%, respectively. When rates were stratified by low, intermediate, and high-risk groups, the 12-year MFS was 99.8%, 98.1%, and 93.8% (p < 0.001), respectively. CSS rates were 99.8%, 98.0%, and 95.3% (p < 0.001) for low, intermediate, and high-risk groups, respectively. Biochemical progression-free survival was 98.7%, 95.9% and 90.4% for low, intermediate, and high-risk patients, respectively (p < 0.001). In multivariate Cox-regression analysis, MFS was mostly closely related to Gleason score and year of treatment, whereas CSS was most closely associated with Gleason score. Conclusions: Excellent CSS and MFS rates are achievable with high-quality brachytherapy for low, intermediate, and high-risk patients. These results compare favorably to alternative treatment modalities. In particular, our MFS and CSS rates for high-risk patients appear superior to those of published radical prostatectomy series.

  7. Views of the solar system

    SciTech Connect (OSTI)

    Hamilton, C.

    1995-02-01T23:59:59.000Z

    Views of the Solar System has been created as an educational tour of the solar system. It contains images and information about the Sun, planets, moons, asteroids and comets found within the solar system. The image processing for many of the images was done by the author. This tour uses hypertext to allow space travel by simply clicking on a desired planet. This causes information and images about the planet to appear on screen. While on a planet page, hyperlinks travel to pages about the moons and other relevant available resources. Unusual terms are linked to and defined in the Glossary page. Statistical information of the planets and satellites can be browsed through lists sorted by name, radius and distance. History of Space Exploration contains information about rocket history, early astronauts, space missions, spacecraft and detailed chronology tables of space exploration. The Table of Contents page has links to all of the various pages within Views Of the Solar System.

  8. For current viewing resistor loads

    DOE Patents [OSTI]

    Lyons, Gregory R. (Tijeras, NM); Hass, Jay B. (Lee's Summit, MO)

    2011-04-19T23:59:59.000Z

    The invention comprises a terminal unit for a flat cable comprising a BNC-PCB connector having a pin for electrically contacting one or more conducting elements of a flat cable, and a current viewing resistor having an opening through which the pin extends and having a resistor face that abuts a connector face of the BNC-PCB connector, wherein the device is a terminal unit for the flat cable.

  9. Binding Energetics of Substitutional and Interstitial Helium and Di-Helium Defects with Grain Boundary Structure in alpha-Fe

    SciTech Connect (OSTI)

    Tschopp, Mark A.; Gao, Fei; Yang, Li; Solanki, K. N.

    2014-01-21T23:59:59.000Z

    he formation/binding energetics and length scales associated with the interaction between He atoms and grain boundaries in BCC alpha-Fe was explored. Ten different low grain boundaries from the <100> and <110> symmetric tilt sigma grain boundary systems were used. In this work, we then calculated formation/binding energies for 1 - 2 He atoms in the substitutional and interstitial sites (HeV, He2V, HeInt, He2Int) at all potential grain boundary sites within 15 °A of the boundary (52826 simulations total). The present results provide detailed information about the interaction energies and length scales of 1-2 He atoms with grain boundaries for the structures examined. A number of interesting new findings emerge from the present study. For instance, the sigma3(112) twin boundary in BCC Fe possesses a much smaller binding energy than other boundaries, which corresponds in long time dynamics simulations to the ability of an interstitial He defect to break away from the boundary in simulations on the order of nanoseconds. Additionally, positive correlations between the calculated formation/binding energies of the He defects (R > 0.9) asserts that the local environment surrounding each site strongly influences the He defect energies and that highly accurate quantum mechanics calculations of lower order defects may be an adequate predictor of higher order defects. Various metrics to quantify or classify the local environment were compared with the He defect binding energies. The present work shows that the binding and formation energies for He defects are important for understanding the physics of He diffusion and trapping by grain boundaries, which can be important for modeling He interactions in polycrystalline steels.

  10. Binding energetics of substitutional and interstitial helium and di-helium defects with grain boundary structure in ?-Fe

    SciTech Connect (OSTI)

    Tschopp, M. A., E-mail: mark.tschopp@gatech.edu [Dynamic Research Corporation, (on site at) U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland 21005 (United States); Center for Advanced Vehicular Systems, Mississippi State University, Starkville, Mississippi 39762 (United States); Gao, F.; Yang, L. [Pacific Northwest National Laboratory, Richland, Washington 99352 (United States); Solanki, K. N. [Arizona State University, School for Engineering of Matter, Transport and Energy, Tempe, Arizona 85287 (United States)

    2014-01-21T23:59:59.000Z

    The formation/binding energetics and length scales associated with the interaction between He atoms and grain boundaries in BCC ?-Fe were explored. Ten different low ? grain boundaries from the ?100? and ?110? symmetric tilt grain boundary systems were used. In this work, we then calculated formation/binding energies for 1–2 He atoms in the substitutional and interstitial sites (HeV, He{sub 2}V, HeInt, He{sub 2}Int) at all potential grain boundary sites within 15?Å of the boundary (52?826 simulations total). The present results provide detailed information about the interaction energies and length scales of 1–2 He atoms with grain boundaries for the structures examined. A number of interesting new findings emerge from the present study. For instance, the ?3(112) twin boundary in BCC Fe possesses a much smaller binding energy than other boundaries, which corresponds in long time dynamics simulations to the ability of an interstitial He defect to break away from the boundary in simulations on the order of nanoseconds. Additionally, positive correlations between the calculated formation/binding energies of the He defects (R?>?0.9) asserts that the local environment surrounding each site strongly influences the He defect energies and that highly accurate quantum mechanics calculations of lower order defects may be an adequate predictor of higher order defects. Various metrics to quantify or classify the local environment were compared with the He defect binding energies. The present work shows that the binding and formation energies for He defects are important for understanding the physics of He diffusion and trapping by grain boundaries, which can be important for modeling He interactions in polycrystalline steels.

  11. Neutron capture therapies

    DOE Patents [OSTI]

    Yanch, Jacquelyn C. (Cambridge, MA); Shefer, Ruth E. (Newton, MA); Klinkowstein, Robert E. (Winchester, MA)

    1999-01-01T23:59:59.000Z

    In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.

  12. ParaView at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeeding access toTestPhysics LabInterconnection RiskMarch StudyParaView

  13. Chisolm View | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty EditCalifornia:PowerCER.png El CER esDataset Country ChileDialogue,China:Chisolm View

  14. Better Buildings Network View | March 2015 | Department of Energy

    Energy Savers [EERE]

    Better Buildings Network View | March 2015 Better Buildings Network View | March 2015 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's...

  15. The Better Buildings Neighborhood View -- December 2013 | Department...

    Office of Environmental Management (EM)

    The Better Buildings Neighborhood View -- December 2013 The Better Buildings Neighborhood View -- December 2013 The Better Buildings Neighborhood View monthly newsletter from the...

  16. Better Buildings Network View | November 2014 | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    November 2014 More Documents & Publications Better Buildings Network View | July-August 2014 Better Buildings Network View | December 2014 Better Buildings Network View | January...

  17. The Better Buildings Neighborhood View - August 2012 | Department...

    Energy Savers [EERE]

    The Better Buildings Neighborhood View - August 2012 The Better Buildings Neighborhood View - August 2012 The Better Buildings Neighborhood View monthly newsletter from the U.S....

  18. Cosmology: a bird's eye view

    E-Print Network [OSTI]

    Alan A. Coley; Sigbjorn Hervik; Woei Chet Lim

    2006-05-15T23:59:59.000Z

    In this essay we discuss the difference in views of the Universe as seen by two different observers. While one of the observers follows a geodesic congruence defined by the geometry of the cosmological model, the other observer follows the fluid flow lines of a perfect fluid with a linear equation of state. We point out that the information these observers collect regarding the state of the Universe can be radically different; while one observes a non-inflating ever-expanding ever-lasting universe, the other observer can experience a dynamical behaviour reminiscent to that of quintessence or even that of a phantom cosmology leading to a 'big rip' singularity within finite time (but without the need for exotic forms of matter).

  19. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

    2008-07-15T23:59:59.000Z

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  20. Reduction of transient diffusion from 1{endash}5 keV Si{sup +} ion implantation due to surface annihilation of interstitials

    SciTech Connect (OSTI)

    Agarwal, A.; Gossmann, H.-.; Eaglesham, D.J.; Pelaz, L.; Jacobson, D.C. [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States)] [Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, New Jersey 07974 (United States); Haynes, T.E. [Oak Ridge National Laboratory, MS-6048, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States)] [Oak Ridge National Laboratory, MS-6048, P.O. Box 2008, Oak Ridge, Tennessee 37831 (United States); Erokhin, Y.E. [Eaton Corporation, 108 Cherry Hill Drive, Beverly, Massachusetts 01950 (United States)] [Eaton Corporation, 108 Cherry Hill Drive, Beverly, Massachusetts 01950 (United States)

    1997-11-01T23:59:59.000Z

    The reduction of transient enhanced diffusion (TED) with reduced implantation energy has been investigated and quantified. A fixed dose of 1{times}10{sup 14} cm{sup {minus}2} Si{sup +} was implanted at energies ranging from 0.5 to 20 keV into boron doping superlattices and enhanced diffusion of the buried boron marker layers was measured for anneals at 810, 950, and 1050{degree}C. A linearly decreasing dependence of diffusivity enhancement on decreasing Si{sup +} ion range is observed at all temperatures, extrapolating to {approximately}1 for 0 keV. This is consistent with our expectation that at zero implantation energy there would be no excess interstitials from the implantation and hence no TED. Monte Carlo modeling and continuum simulations are used to fit the experimental data. The results are consistent with a surface recombination length for interstitials of {lt}10 nm. The data presented here demonstrate that in the range of annealing temperatures of interest for p-n junction formation, TED is reduced at smaller ion implantation energies and that this is due to increased interstitial annihilation at the surface. {copyright} {ital 1997 American Institute of Physics.}

  1. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01T23:59:59.000Z

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  2. Better Buildings Network View | May 2014 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    May 2014 More Documents & Publications Better Buildings Network View | July-August 2014 Better Buildings Network View | June...

  3. In vivo photodynamic therapy using upconversion nanoparticles as remote-

    E-Print Network [OSTI]

    Chaudhuri, Sanjay

    destruction. Moreover, invasive interstitial PDT which involves percutaneous implantation of light emitting diode (LED) probes arranged in a cylinder tip to fit into a balloon catheter to illuminate tumors

  4. MyRED Mobiles Student Views

    E-Print Network [OSTI]

    Farritor, Shane

    tap on Shopping Cart, then select term. Tap on Class Search to find courses to place in your shoppingMyRED Mobiles Student Views Mar 2014 Page 1 Login/Sign-in Enter your MyRED /TrueYou credentials. Tap on any Term bar to view a schedule for the selected term. Home Screen/Main Menu Class Schedule

  5. Groundwater Modeling in ArcView: by integrating ArcView, MODFLOW and

    E-Print Network [OSTI]

    Sengupta, Raja

    Groundwater Modeling in ArcView: by integrating ArcView, MODFLOW and MODPATH Abstract Modeling. This paper addresses groundwater modeling which is one of the many entities in environmental modeling in ArcView 3.2a. The objective was to create an integrated system where a user could do groundwater

  6. Honors Enrichment Contracts Faculty View Page 1 Honors Enrichment Contracts Faculty View

    E-Print Network [OSTI]

    Honors Enrichment Contracts ­ Faculty View Page 1 Honors Enrichment Contracts ­ Faculty View INITIAL APPROVAL #12;Honors Enrichment Contracts ­ Faculty View Page 2 Summary This document contains information about how to make initial and final decisions on Honors Enrichment Contracts submitted by honors

  7. High-Dose-Rate Interstitial Brachytherapy as Monotherapy for Clinically Localized Prostate Cancer: Treatment Evolution and Mature Results

    SciTech Connect (OSTI)

    Zamboglou, Nikolaos [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany)] [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Tselis, Nikolaos, E-mail: ntselis@hotmail.com [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany)] [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Baltas, Dimos [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany)] [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany); Buhleier, Thomas [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany)] [Department of Radiation Oncology, Klinikum Offenbach, Offenbach (Germany); Martin, Thomas [Department of Radiation Oncology, Klinikum Bremen-Mitte, Bremen (Germany)] [Department of Radiation Oncology, Klinikum Bremen-Mitte, Bremen (Germany); Milickovic, Natasa; Papaioannou, Sokratis [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany)] [Department of Medical Physics and Engineering, Klinikum Offenbach, Offenbach (Germany); Ackermann, Hanns [Institute of Biostatistics, J.W. Goethe University of Frankfurt, Frankfurt (Germany)] [Institute of Biostatistics, J.W. Goethe University of Frankfurt, Frankfurt (Germany); Tunn, Ulf W. [Department of Urology, Klinikum Offenbach, Offenbach (Germany)] [Department of Urology, Klinikum Offenbach, Offenbach (Germany)

    2013-03-01T23:59:59.000Z

    Purpose: To report the clinical outcome of high-dose-rate (HDR) interstitial (IRT) brachytherapy (BRT) as sole treatment (monotherapy) for clinically localized prostate cancer. Methods and Materials: Between January 2002 and December 2009, 718 consecutive patients with clinically localized prostate cancer were treated with transrectal ultrasound (TRUS)-guided HDR monotherapy. Three treatment protocols were applied; 141 patients received 38.0 Gy using one implant in 4 fractions of 9.5 Gy with computed tomography-based treatment planning; 351 patients received 38.0 Gy in 4 fractions of 9.5 Gy, using 2 implants (2 weeks apart) and intraoperative TRUS real-time treatment planning; and 226 patients received 34.5 Gy, using 3 single-fraction implants of 11.5 Gy (3 weeks apart) and intraoperative TRUS real-time treatment planning. Biochemical failure was defined according to the Phoenix consensus, and toxicity was evaluated using Common Toxicity Criteria for Adverse Events version 3. Results: The median follow-up time was 52.8 months. The 36-, 60-, and 96-month biochemical control and metastasis-free survival rates for the entire cohort were 97%, 94%, and 90% and 99%, 98%, and 97%, respectively. Toxicity was scored per event, with 5.4% acute grade 3 genitourinary and 0.2% acute grade 3 gastrointestinal toxicity. Late grade 3 genitourinary and gastrointestinal toxicities were 3.5% and 1.6%, respectively. Two patients developed grade 4 incontinence. No other instance of grade 4 or greater acute or late toxicity was reported. Conclusion: Our results confirm IRT-HDR-BRT is safe and effective as monotherapy for clinically localized prostate cancer.

  8. Helical Tomotherapy Delivery of an IMRT Boost in Lieu of Interstitial Brachytherapy in the Setting of Gynecologic Malignancy: Feasibility and Dosimetric Comparison

    SciTech Connect (OSTI)

    Gielda, Benjamin T., E-mail: Benjamin_gielda@rush.ed [Department of Radiation Oncology, Rush University Medical Center, Chicago IL (United States); Shah, Anand P.; Marsh, James C.; Smart, Joseph P.; Bernard, Damian [Department of Radiation Oncology, Rush University Medical Center, Chicago IL (United States); Rotmensch, Jacob [Section of Gynecologic Oncology, Rush University Medical Center, Chicago IL (United States); Griem, Katherine L. [Department of Radiation Oncology, Rush University Medical Center, Chicago IL (United States)

    2011-07-01T23:59:59.000Z

    Interstitial brachytherapy is an important means by which to improve local control in gynecologic malignancy when intracavitary brachytherapy is untenable. Patients unable to receive brachytherapy have traditionally received conventional external beam radiation alone with modest results. We investigated the ability of Tomotherapy (Tomotherapy Inc., Madison, WI) to replace interstitial brachytherapy. Six patients were selected. The planning CT of each patient was contoured with the planning target volume (PTV), bladder, rectum, femoral heads, and bowel. Identical contour sets were exported to Tomotherapy and Nucletron PLATO (Nucletron B.V., Veenendaal, The Netherlands). With Tomotherapy, the PTV was prescribed 31 Gy in 5 fractions to 90% of the volume. With PLATO, 600 cGy x 5 fractions was prescribed to the surface of the PTV. Dose delivered was normalized to 2 Gy fractions (EQD2) and added to a hypothetical homogenous 45-Gy pelvic dose. Tomotherapy achieved a D90 of 87 Gy EQD2 versus 86 Gy with brachytherapy. PTV dose was more homogeneous with tomotherapy. The dose to the most at-risk 2 mL of bladder and rectum with Tomotherapy was of 78 and 71 Gy EQD2 versus 81 and 75 Gy with brachytherapy. Tomotherapy delivered more dose to the femoral heads (mean 1.23 Gy per fraction) and bowel. Tomotherapy was capable of replicating the peripheral dose achieved with brachytherapy, without the PTV hotspots inherent to interstitial brachytherapy. Similar maximum doses to bowel and bladder were achieved with both methods. Excessive small bowel and femoral head toxicity may result if previous pelvic irradiation is not planned accordingly. Significant challenges related to interfraction and intrafraction motion must be overcome if treatment of this nature is to be contemplated.

  9. A view-sequential 3D display

    E-Print Network [OSTI]

    Cossairt, Oliver S. (Oliver Strider), 1978-

    2003-01-01T23:59:59.000Z

    This thesis outlines the various techniques for creating electronic 3D displays and analyzes their commercial potential. The thesis argues for the use of view-sequential techniques in the design of 3D displays based on ...

  10. California's Energy Future - The View to 2050

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    carbon capture and storage, especially as a technology thatCarbon capture and sequestration CCST California Council on Science and Technologytechnology California’s Energy Future - The View to 2050 becomes available. ? ? Fossil fuel with carbon capture

  11. The new option view of investment

    E-Print Network [OSTI]

    Dixit, Avinash K.

    1995-01-01T23:59:59.000Z

    This paper provides a simple introduction to the new option view of investment. We explain the shortcomings of the orthodox theory, and then outline the basic ideas behind the option framework. Several industry examples ...

  12. JOBAID-VIEWING AN EMPLOYEE MATRIX (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide supervisor users through the step-by-step process of viewing an employee matrix within SuccessFactors Learning.

  13. Incorporating video into Google Mobile Street View

    E-Print Network [OSTI]

    Wright, Christina (Christina E.)

    2010-01-01T23:59:59.000Z

    Mobile Street View is a compelling application but suffers from significant latency problems, especially in limited bandwidth circumstances. Currently, the application uses static images to display street level information. ...

  14. Jefferson and Hamilton as viewed by historians

    E-Print Network [OSTI]

    Jungmeyer, Paul Edward

    1970-01-01T23:59:59.000Z

    JEFFERSON AND HAMILTON AS VIEHED BY HISTORIANS A Thesis Paul Edward Jungmeyer Submitted to the Graduate College of Texas A&M University in ' partial fulfillment of the requirement for the degree of MASTER OF ARTS August, 1970 Major Subject...: History JEFFERSON AND HAMILTON AS VIEWED BY HISTORIANS A Thesis by Paul Edward Jungmeyer Approved as to style and content by: (Chairman of Committee d i~) (Member) (M er) August, 1970 ABSTRACT JEFFERSON AND HAMILTON AS VIEWED BY HISTORIANS...

  15. HEALTHCARESCIENCES Physical & Occupational Therapy, Cytotechnology, Dental Hygiene,

    E-Print Network [OSTI]

    New Hampshire, University of

    competition for admittance to physical therapy programs. Obtain knowledge of several basic sciences including, accident, or congenital handicap. Physical therapy seeks to improve mobility, relieve pain, or minimize Research Consultation SpecialtiesInclude: Pediatrics Geriatrics Sports Medicine Orthopedics Neurology

  16. STANFORD REDWOOD CITY INFUSION THERAPY CENTER

    E-Print Network [OSTI]

    Bejerano, Gill

    STANFORD REDWOOD CITY INFUSION THERAPY CENTER Stanford Redwood City Infusion Therapy Center 450 that the new Stanford Redwood City Infusion Therapy Center opened on January 6, 2014. This new state previously received infusion treatments in the Infusion Treatment Area (ITA) at the Stanford Cancer Center

  17. axial view inductively: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    View of Induction Reasoning for First-Order Logic Physics Websites Summary: , The Alan Turing Centenary Conference (2012)" 12;A Unified View of Induction Reasoning for First in...

  18. Residential Windows and Window Coverings: A Detailed View of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Residential Windows and Window Coverings: A Detailed View of the Installed Base and User Behavior Residential Windows and Window Coverings: A Detailed View of the Installed Base...

  19. Better Buildings Network View | April 2014 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    April 2014 More Documents & Publications Better Buildings Network View | December 2014 Better Buildings Residential Network Orientation Better Buildings Network View | November...

  20. Better Buildings Network View | February 2014 | Department of...

    Energy Savers [EERE]

    February 2014 Better Buildings Network View | February 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

  1. Better Buildings Network View | January 2015 | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    5 More Documents & Publications Better Buildings Network View | December 2014 Better Buildings Network View | November 2014 Better Buildings Residential Network Orientation...

  2. Better Buildings Network View | June 2014 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    June 2014 Better Buildings Network View | June 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network....

  3. Better Buildings Network View | March 2014 | Department of Energy

    Energy Savers [EERE]

    March 2014 Better Buildings Network View | March 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

  4. Better Buildings Network View | December 2014 | Department of...

    Energy Savers [EERE]

    December 2014 Better Buildings Network View | December 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

  5. Better Buildings Network View | January 2014 | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 Better Buildings Network View | January 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network....

  6. Better Buildings Network View | October 2014 | Department of...

    Energy Savers [EERE]

    October 2014 Better Buildings Network View | October 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

  7. Better Buildings Network View | February 2015 | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    5 More Documents & Publications Better Buildings Network View | November 2014 Better Buildings Network View | September 2014 Better Buildings Residential Network Case Study:...

  8. Measurements using tangentially viewing bolometers on TFTR

    SciTech Connect (OSTI)

    Bush, C.E.; Schivell, J.; Budny, R.; Ellis R.A. III; Goldston, R.J.; McCune, D.; Medley, S.S.; Scott, S.D.; Towner, H.H.; Wieland, R.M.; and others

    1988-08-01T23:59:59.000Z

    Co- and counter-viewing bolometers aimed along a common tangency chord are being used to study power losses due to charge exchange (CX) of fast ions in neutral beam injection (NBI) heated TFTR plasmas. For unidirectional injection, tangential bolometers oriented to view CX loss of circulating fast ions detect losses from the thermal target plasma (impurity radiation and CX) plus power due to the fast ion CX loss, whereas bolometers oppositely directed measure only the target plasma contribution. The difference between the two signals is a measure of the fast ion CX loss. Additional information is obtained by comparing the tangential bolometer signals with those of perpendicularly viewing bolometer monitors and arrays. The measurements are compared to results of the TRANSP code analysis.

  9. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2013/14 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  10. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    Barrett, Jeffrey A.

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2012/13 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  11. Project Title: Older People's View of

    E-Print Network [OSTI]

    Hickman, Mark

    /AGECONCERN/10/NP Age Concern Canterbury provides support for older people, many of whom face loneliness, lowProject Title: Older People's View of Community Support Bachelor of Arts Internship Company information, support and advocacy, to enable older people in Canterbury to have real choices". (http

  12. CITY OF MOUNTAIN VIEW April 12, 2011 .

    E-Print Network [OSTI]

    Ordinance ordinance? Projected effective date: September 1, 2011 Green building or stand-alone energy Energy Ordinance in Combination with Green Building ordinance? Do minimum energy requirements increase No afterCITY OF MOUNTAIN VIEW April 12, 2011 . CaUfomia Energy Commission Attn: Joe Loyer 1516 Ninth

  13. Friction in full view A. P. Merklea

    E-Print Network [OSTI]

    Marks, Laurence D.

    Friction in full view A. P. Merklea and L. D. Marksb Materials Science and Engineering proposed friction mechanisms explaining the unique tribological properties of graphite. Wear of graphite chemical or struc- tural information from the interface during a friction experi- ment. Examples

  14. INVESTIGATION Retrospective View of North American Potato

    E-Print Network [OSTI]

    Douches, David S.

    INVESTIGATION Retrospective View of North American Potato (Solanum tuberosum L.) Breeding in the 20, Madison, Wisconsin, 53706 ABSTRACT Cultivated potato (Solanum tuberosum L.), a vegetatively propagated explore the effects of potato breeding at the genome level, we used 8303 single-nucleotide polymorphism

  15. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-12-03T23:59:59.000Z

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  16. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-06-25T23:59:59.000Z

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  17. Compact accelerator for medical therapy

    DOE Patents [OSTI]

    Caporaso, George J.; Chen, Yu-Jiuan; Hawkins, Steven A.; Sampayan, Stephen E.; Paul, Arthur C.

    2010-05-04T23:59:59.000Z

    A compact accelerator system having an integrated particle generator-linear accelerator with a compact, small-scale construction capable of producing an energetic (.about.70-250 MeV) proton beam or other nuclei and transporting the beam direction to a medical therapy patient without the need for bending magnets or other hardware often required for remote beam transport. The integrated particle generator-accelerator is actuable as a unitary body on a support structure to enable scanning of a particle beam by direction actuation of the particle generator-accelerator.

  18. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A. (Riverside, CA); Beloussov, Alexandre V. (Bernardino, CA); Bakir, Julide (Alta Loma, CA); Armon, Deganit (Redlands, CA); Olsen, Howard B. (Colton, CA); Salem, Dana (Riverside, CA)

    2008-07-08T23:59:59.000Z

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  19. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A. (Riverside, CA); Beloussov, Alexandre V. (San Bernardino, CA); Bakir, Julide (Alta Loma, CA); Armon, Deganit (Longmeadow, MA); Olsen, Howard B. (Irvine, CA); Salem, Dana (Riverside, CA)

    2010-09-21T23:59:59.000Z

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  20. Proton Therapy - Accelerating Protons to Save Lives

    SciTech Connect (OSTI)

    Keppel, Cynthia (Hampton University Proton Therapy) [Hampton University Proton Therapy

    2011-10-25T23:59:59.000Z

    In 1946, physicist Robert Wilson first suggested that protons could be used as a form of radiation therapy in the treatment of cancer because of the sharp drop-off that occurs on the distal edge of the radiation dose. Research soon confirmed that high-energy protons were particularly suitable for treating tumors near critical structures, such as the heart and spinal column. The precision with which protons can be delivered means that more radiation can be deposited into the tumor while the surrounding healthy tissue receives substantially less or, in some cases, no radiation. Since these times, particle accelerators have continuously been used in cancer therapy and today new facilities specifically designed for proton therapy are being built in many countries. Proton therapy has been hailed as a revolutionary cancer treatment, with higher cure rates and fewer side effects than traditional X-ray photon radiation therapy. Proton therapy is the modality of choice for treating certain small tumors of the eye, head or neck. Because it exposes less of the tissue surrounding a tumor to the dosage, proton therapy lowers the risk of secondary cancers later in life - especially important for young children. To date, over 80,000 patients worldwide have been treated with protons. Currently, there are nine proton radiation therapy facilities operating in the United States, one at the Hampton University Proton Therapy Institute. An overview of the treatment technology and this new center will be presented.

  1. ORIGINAL CONTRIBUTION Pharmacogenetic Study of Statin Therapy

    E-Print Network [OSTI]

    Posada, David

    ORIGINAL CONTRIBUTION Pharmacogenetic Study of Statin Therapy and Cholesterol Reduction Daniel I apolipoprotein E (APOE), apolipoprotein B (APOB), cho- lesteryl ester transfer protein (CETP), and the LDL

  2. A Prospective Longitudinal Clinical Trial Evaluating Quality of Life After Breast-Conserving Surgery and High-Dose-Rate Interstitial Brachytherapy for Early-Stage Breast Cancer

    SciTech Connect (OSTI)

    Garsa, Adam A.; Ferraro, Daniel J.; DeWees, Todd A. [Department of Radiation Oncology, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Deshields, Teresa L. [Department of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Margenthaler, Julie A.; Cyr, Amy E. [Department of Surgery, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Naughton, Michael [Department of Medicine, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Aft, Rebecca [Department of Surgery, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Department of Surgery, John Cochran Veterans Hospital, St. Louis, Missouri (United States); Gillanders, William E.; Eberlein, Timothy [Department of Surgery, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Matesa, Melissa A.; Ochoa, Laura L. [Department of Radiation Oncology, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States); Zoberi, Imran, E-mail: izoberi@radonc.wustl.edu [Department of Radiation Oncology, Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri (United States)

    2013-12-01T23:59:59.000Z

    Purpose: To prospectively examine quality of life (QOL) of patients with early stage breast cancer treated with accelerated partial breast irradiation (APBI) using high-dose-rate (HDR) interstitial brachytherapy. Methods and Materials: Between March 2004 and December 2008, 151 patients with early stage breast cancer were enrolled in a phase 2 prospective clinical trial. Eligible patients included those with Tis-T2 tumors measuring ?3 cm excised with negative surgical margins and with no nodal involvement. Patients received 3.4 Gy twice daily to a total dose of 34 Gy. QOL was measured using European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, version 3.0, and QLQ-BR23 questionnaires. The QLQ-C30 and QLQ-BR23 questionnaires were evaluated during pretreatment and then at 6 to 8 weeks, 3 to 4 months, 6 to 8 months, and 1 and 2 years after treatment. Results: The median follow-up was 55 months. Breast symptom scores remained stable in the months after treatment, and they significantly improved 6 to 8 months after treatment. Scores for emotional functioning, social functioning, and future perspective showed significant improvement 2 years after treatment. Symptomatic fat necrosis was associated with several changes in QOL, including increased pain, breast symptoms, systemic treatment side effects, dyspnea, and fatigue, as well as decreased role functioning, emotional functioning, and social functioning. Conclusions: HDR multicatheter interstitial brachytherapy was well tolerated, with no significant detrimental effect on measured QOL scales/items through 2 years of follow-up. Compared to pretreatment scores, there was improvement in breast symptoms, emotional functioning, social functioning, and future perspective 2 years after treatment.

  3. Lab 9 LabVIEW and GPIB LabVIEW (National Instruments)

    E-Print Network [OSTI]

    Glashausser, Charles

    Automatic data acquisition DAC 01010 Actuator, Heater... control Power amplifiers LabVIEW GPIB GPIB #12 Toolbar Retain Wire Values Button Step Function Buttons #12;Block Diagram Window Front Panel Window

  4. View of software for HEP experiments

    SciTech Connect (OSTI)

    Johnstad, H.; Lebrun, P.; Lessner, E.S.; Montgomery, H.E.

    1986-05-01T23:59:59.000Z

    A view of the software structure typical of a High Energy Physics experiment is given and the availability of general software modules in most of the important regions is discussed. The aim is to provide a framework for discussion of capabilities and inadequecies and thereby define areas where effort should be assigned and perhaps also to serve as a useful source document for the newcomer to High Energy Physics. 74 refs.

  5. Method for microbeam radiation therapy

    DOE Patents [OSTI]

    Slatkin, D.N.; Dilmanian, F.A.; Spanne, P.O.

    1994-08-16T23:59:59.000Z

    A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings

  6. eSales Interactive Mapping -Viewing and Printing Introduction

    E-Print Network [OSTI]

    eSales Interactive Mapping - Viewing and Printing Introduction Our eSales system includes an integrated interactive map facility. This allows you to view and print maps for all lots on offer. Various

  7. Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material Erin Baker Keywords: Biofuels; Technology R&D; Uncertainty; Environmental policy 2 #12;1 Introduction This paper contains supplementary material for "Cellulosic Biofuels: Expert Views on Prospects for Advancement

  8. Better Buildings Network View | July-August 2014 | Department...

    Energy Savers [EERE]

    July-August 2014 Better Buildings Network View | July-August 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings...

  9. Alternative Views on Knowledge: Presentation of Open Learner Models

    E-Print Network [OSTI]

    Bull, Susan

    a learner with a graphical view of their Bayesian learner model. STyLE-OLM [2] works with the learner

  10. aperture radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  11. antiandrogen flutamide therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  12. aroma therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  13. adjuvant radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  14. abdominopelvic radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  15. antiproton radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  16. abdominal radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  17. adaptive radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  18. analysis radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  19. aapm radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  20. accelerated radiation therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  1. Impact of Decontamination Therapy on Ultrasound Visualization of Ingested Pills

    E-Print Network [OSTI]

    Bothwell, Jason; Skinner, Carl; Della-Giustina, David; Kang, Christopher; Cookman, Laura; Laselle, Brooks

    2014-01-01T23:59:59.000Z

    R esearch Impact of Decontamination Therapy on Ultrasoundused for gastric decontamination on examiners’ ability toet al Impact of Decontamination Therapy often required to

  2. Loop Quantum Gravity: An Inside View

    E-Print Network [OSTI]

    Thomas Thiemann

    2006-08-29T23:59:59.000Z

    This is a (relatively) non -- technical summary of the status of the quantum dynamics in Loop Quantum Gravity (LQG). We explain in detail the historical evolution of the subject and why the results obtained so far are non -- trivial. The present text can be viewed in part as a response to an article by Nicolai, Peeters and Zamaklar [hep-th/0501114]. We also explain why certain no go conclusions drawn from a mathematically correct calculation in a recent paper by Helling et al [hep-th/0409182] are physically incorrect.

  3. Better Buildings Network View, March 2015

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergy Christopher|for1, 20114, 2013Better NewsNetwork View

  4. TotalView | Argonne Leadership Computing Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool ofTopo II:7.1 7.0 8.04.2 7.6 16.6TotalView

  5. Lake View Geothermal Facility | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOf Kilauea Volcano, Hawaii9969995°,ILEDSGP/joinHavasuPalmdaleLake View

  6. View from the Bridge | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your DensityEnergy U.S.-China Electric Vehicle and03/02Report | DepartmentTRUVictor Der About Us VictorView

  7. Validation of mathematical models for the prediction of organs-at-risk dosimetric metrics in high-dose-rate gynecologic interstitial brachytherapy

    SciTech Connect (OSTI)

    Damato, Antonio L.; Viswanathan, Akila N.; Cormack, Robert A. [Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115 (United States)] [Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115 (United States)

    2013-10-15T23:59:59.000Z

    Purpose: Given the complicated nature of an interstitial gynecologic brachytherapy treatment plan, the use of a quantitative tool to evaluate the quality of the achieved metrics compared to clinical practice would be advantageous. For this purpose, predictive mathematical models to predict the D{sub 2cc} of rectum and bladder in interstitial gynecologic brachytherapy are discussed and validated.Methods: Previous plans were used to establish the relationship between D2cc and the overlapping volume of the organ at risk with the targeted area (C0) or a 1-cm expansion of the target area (C1). Three mathematical models were evaluated: D{sub 2cc}=?*C{sub 1}+? (LIN); D{sub 2cc}=?– exp(–?*C{sub 0}) (EXP); and a mixed approach (MIX), where both C{sub 0} and C{sub 1} were inputs of the model. The parameters of the models were optimized on a training set of patient data, and the predictive error of each model (predicted D{sub 2cc}? real D{sub 2cc}) was calculated on a validation set of patient data. The data of 20 patients were used to perform a K-fold cross validation analysis, with K = 2, 4, 6, 8, 10, and 20.Results: MIX was associated with the smallest mean prediction error <6.4% for an 18-patient training set; LIN had an error <8.5%; EXP had an error <8.3%. Best case scenario analysis shows that an error ?5% can be achieved for a ten-patient training set with MIX, an error ?7.4% for LIN, and an error ?6.9% for EXP. The error decreases with the increase in training set size, with the most marked decrease observed for MIX.Conclusions: The MIX model can predict the D{sub 2cc} of the organs at risk with an error lower than 5% with a training set of ten patients or greater. The model can be used in the development of quality assurance tools to identify treatment plans with suboptimal sparing of the organs at risk. It can also be used to improve preplanning and in the development of real-time intraoperative planning tools.

  8. Computer simulation of neutron capture therapy.

    E-Print Network [OSTI]

    Olson, Arne Peter

    1967-01-01T23:59:59.000Z

    Analytical methods are developed to simulate on a large digital computer the production and use of reactor neutron beams f or boron capture therapy of brain tumors. The simulation accounts for radiation dose distributions ...

  9. Computer simulation of neutron capture therapy

    E-Print Network [OSTI]

    Olson, Arne Peter

    1967-01-01T23:59:59.000Z

    Analytical methods are developed to simulate on a large digital computer the production and use of reactor neutron beams f or boron capture therapy of brain tumors. The simulation accounts for radiation dose distributions ...

  10. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

  11. Nonclinical safety strategies for stem cell therapies

    SciTech Connect (OSTI)

    Sharpe, Michaela E., E-mail: michaela_sharpe@yahoo.com [Investigative Toxicology, Drug Safety Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, CT13 9NJ (United Kingdom); Morton, Daniel [Exploratory Drug Safety, Drug Safety Research and Development, Pfizer Inc, Cambridge, 02140 (United States)] [Exploratory Drug Safety, Drug Safety Research and Development, Pfizer Inc, Cambridge, 02140 (United States); Rossi, Annamaria [Investigative Toxicology, Drug Safety Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, CT13 9NJ (United Kingdom)] [Investigative Toxicology, Drug Safety Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, CT13 9NJ (United Kingdom)

    2012-08-01T23:59:59.000Z

    Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative diseases, inflammatory conditions, cancer and repair of damaged tissue. The safety of a stem cell therapy depends on many factors including the type of cell therapy, the differentiation status and proliferation capacity of the cells, the route of administration, the intended clinical location, long term survival of the product and/or engraftment, the need for repeated administration, the disease to be treated and the age of the population. Understanding the product profile of the intended therapy is crucial to the development of the nonclinical safety study design.

  12. Anesthesia for intraoperative radiation therapy in children

    SciTech Connect (OSTI)

    Friesen, R.H.; Morrison, J.E. Jr.; Verbrugge, J.J.; Daniel, W.E.; Aarestad, N.O.; Burrington, J.D.

    1987-06-01T23:59:59.000Z

    Intraoperative radiation therapy (IORT) is a relatively new mode of cancer treatment which is being used with increasing frequency. IORT presents several challenges to the anesthesiologist, including patients who are debilitated from their disease or chemotherapy, operations involving major tumor resections, intraoperative interdepartmental transport of patients, and remote monitoring of patients during electron beam therapy. This report discusses the anesthetic management of ten children undergoing IORT. With adequate preparation and interdepartmental communication, complications can be avoided during these challenging cases.

  13. Alopecia: A review of laser and light therapies

    E-Print Network [OSTI]

    Rangwala, Sophia; Rashid, Rashid M

    2012-01-01T23:59:59.000Z

    with alopecia. ACKNOWLEDGEMENT: Sophia Rangwala gratefullyof laser and light therapies Sophia Rangwala AB, Rashid M

  14. September 2013 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Drug Retention Times Center for Human Reliability Studies (2007) 29 > Oleoresin Capsicum...

  15. ALS Technique Gives Novel View of Lithium Battery Dendrite Growth

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Technique Gives Novel View of Lithium Battery Dendrite Growth Print Lithium-ion batteries, popular in today's electronic devices and electric vehicles, could gain significant...

  16. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    March 2014 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A....

  17. January 2013 Most Viewed Documents for Power Generation And Distributi...

    Office of Scientific and Technical Information (OSTI)

    January 2013 Most Viewed Documents for Power Generation And Distribution Lessons from Large-Scale Renewable Energy Integration Studies: Preprint Bird, L.; Milligan, M. Small punch...

  18. Newbie question: How to view commercial/residential load profile...

    Open Energy Info (EERE)

    Newbie question: How to view commercialresidential load profile datasets? Home > Groups > Buildings I have downloaded SAM (20112414) and cannot access open the .tar files. Help...

  19. New ALS Technique Gives Nanoscale Views of Complex Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoscale Views of Complex Systems Print Studying and identifying molecules at the mesoscale has always been challenging-even the best microscopes and spectrometers have...

  20. Better Buildings Network View | September 2014 | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Financing Program: On-Bill Financing Brings Lenders and Homeowners On Board Better Buildings Network View | December 2014 On-Bill Financing for Energy Efficiency Improvements...

  1. March 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United...

  2. The Better Buildings Neighborhood View - July 2013 | Department...

    Energy Savers [EERE]

    Better Buildings Neighborhood View - October 2012 Better Buildings Neighborhood Program Home Accomplishments History Better Buildings Partners Stories Interviews Videos Contact Us...

  3. Performance viewing and editing in ASSESS Outsider

    SciTech Connect (OSTI)

    Snell, M.K. [Sandia National Labs., Albuquerque, NM (US); Key, B.; Bingham, B. [Science and Engineering Associates, Inc., Albuquerque, NM (US)

    1993-07-01T23:59:59.000Z

    The Analytic System and Software for Evaluation of Safeguards and Security (ASSESS) Facility module records site information in the path elements and areas of an Adversary Sequence Diagram. The ASSESS Outsider evaluation module takes this information and first calculates performance values describing how much detection and delay is assigned at each path element and then uses the performance values to determine most-vulnerable paths. This paper discusses new Outsider capabilities that allow the user to view how elements are being defeated and to modify some of these values in Outsider. Outsider now displays how different path element segments are defeated and contrasts the probability of detection for alternate methods of defeating a door (e.g., the lock or the door face itself). The user can also override element segment delays and detection probabilities directly during analysis in Outsider. These capabilities allow users to compare element performance and to verify correct path element performance for all elements, not just those on the most-vulnerable path as is the case currently. Improvements or reductions in protection can be easily checked without creating a set of new facility files to accomplish it.

  4. A HYPERSPECTRAL VIEW OF THE CRAB NEBULA

    SciTech Connect (OSTI)

    Charlebois, M.; Drissen, L.; Bernier, A.-P. [Departement de Physique, de Genie Physique et d'Optique, Universite Laval, Quebec, Quebec G1V 0A6 (Canada); Grandmont, F. [ABB Bomem Inc., 585 boulevard Charest est, Suite 300, Quebec, Quebec G1K 9H4 (Canada); Binette, L., E-mail: maxime.charlebois.1@ulaval.c, E-mail: ldrissen@phy.ulaval.c, E-mail: anne-pier.bernier.1@ulaval.c [Instituto de AstronomIa, UNAM, Ap.70-264, 04510 Mexico, DF (Mexico)

    2010-05-15T23:59:59.000Z

    We have obtained spatially resolved spectra of the Crab nebula in the spectral ranges 450-520 nm and 650-680 nm, encompassing the H{beta}, [O III] {lambda}4959, {lambda}5007, H{alpha}, [N II] {lambda}6548, {lambda}6584, and [S II] {lambda}6717, {lambda}6731 emission lines, with the imaging Fourier transform spectrometer SpIOMM at the Observatoire du Mont-Megantic's 1.6 m telescope. We first compare our data with published observations obtained either from a Fabry-Perot interferometer or from a long-slit spectrograph. Using a spectral deconvolution technique similar to the one developed by Cadez et al., we identify and resolve multiple emission lines separated by large Doppler shifts and contained within the rapidly expanding filamentary structure of the Crab. This allows us to measure important line ratios, such as [N II]/H{alpha}, [S II]/H{alpha}, and [S II] {lambda}6717 /[S II] {lambda}6731 of individual filaments, providing a new insight on the SE-NW asymmetry in the Crab. From our analysis of the spatial distribution of the electronic density and of the respective shocked versus photoionized gas components, we deduce that the skin-less NW region must have evolved faster than the rest of the nebula. Assuming a very simple expansion model for the ejecta material, our data provide us with a complete tridimensional view of the Crab.

  5. Three Views of a Secret in Relativistic Thermodynamics

    E-Print Network [OSTI]

    Tadas K. Nakamura

    2008-12-19T23:59:59.000Z

    It has been shown three different views in relativistic thermodynamics can be derived from the basic formulation proposed by van Kampen and Israel. The way to decompose energy-momentum into the reversible and irreversible parts is not uniquely determined, and different choices result in different views. The effect of difference in the definition of a finite volume is also considered.

  6. O'Leary outlines policy views at confirmation hearing

    SciTech Connect (OSTI)

    Simpson, J.

    1993-02-15T23:59:59.000Z

    In her confirmation hearing, Secretary O'Leary outlined her views on various controversial issues. Among these were management of Yucca Mountain and the search for a nuclear waste repository, research on alternative fuels, encouragement of the use of renewable energy sources, and her views on intergrated resource planning.

  7. Updatable Process Views for Adapting Large Process Models

    E-Print Network [OSTI]

    Ulm, Universität

    Updatable Process Views for Adapting Large Process Models: The proView Demonstrator Jens Kolb. The increasing adoption of process-aware information sys- tems (PAISs) has resulted in large process model collections. To support users having different perspectives on these processes and related data, a PAIS should

  8. Nanofabricated upconversion nanoparticles for photodynamic therapy

    E-Print Network [OSTI]

    Nanofabricated upconversion nanoparticles for photodynamic therapy Baris Ungun,1 Robert K. Prud for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up- converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent

  9. Porphyrins for boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko (Center Moriches, NY); Gabel, Detlef (Bremen, DE)

    1990-01-01T23:59:59.000Z

    Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.

  10. DISCIPLINE OF RADIATION THERAPY SAFETY DOCUMENT

    E-Print Network [OSTI]

    O'Mahony, Donal E.

    DISCIPLINE OF RADIATION THERAPY SAFETY DOCUMENT Contents Page 1. Health & Safety arrangements 1 Inspection 1.4 Hazard Reporting 1.5 Security in College 1.6 Out of Hours Working 1.7 Management of Work.7 Management of Work-related Stress Those experiencing symptoms of work-related stress should raise this matter

  11. CLINICAL PERFORMANCE EVALUATION Physical Therapy Program

    E-Print Network [OSTI]

    Sheridan, Jennifer

    CLINICAL PERFORMANCE EVALUATION Physical Therapy Program University of Wisconsin-Madison Student. Areas needing improvement: This evaluation has been discussed with the students Yes No Clinical Instructor Student Date Please Note: The focus of this 2-week clinical experience is to provide students

  12. Improving Targeted Radionuclide Therapy Using Nuclear Nanotechnology 

    E-Print Network [OSTI]

    Evans, Jordan Andrew

    2013-05-03T23:59:59.000Z

    IMPROVING TARGETED RADIONUCLIDE THERAPY USING NUCLEAR NANOTECHNOLOGY A Thesis by JORDAN ANDREW EVANS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of Nanotechnology ................................................. 4 1.3 Paradigm Shift - Improving TRT Using Nuclear Nanotechnology .......... 8 1.4 Cancer Cell Line Investigated in This Study .......................................... 14 1.5 Nano...

  13. Cell Death Pathways in Photodynamic Therapy of Cancer

    E-Print Network [OSTI]

    Mroz, Pawel

    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...

  14. Mindfulness and Attachment Security as Predictors of Sucess in Therapy

    E-Print Network [OSTI]

    Martin, David Matthew

    2012-08-31T23:59:59.000Z

    This work focuses on the role of mindfulness and attachment security as agents of change in successful therapy. Two studies were conducted to investigate the mechanisms underlying change that may lead to successful therapy - as reflected...

  15. Radiobiology of normal rat lung in Boron Neutron Capture Therapy

    E-Print Network [OSTI]

    Kiger, Jingli Liu

    2006-01-01T23:59:59.000Z

    Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing ...

  16. In-situ measurement of electrodermal activity during occupational therapy

    E-Print Network [OSTI]

    Hedman, Elliott B. (Elliot Bruce)

    2010-01-01T23:59:59.000Z

    Physiological arousal is an important part of occupational therapy for children with Sensory Processing Disorder (SPD) but therapists do not have a way to objectively measure how therapy affects arousal. We hypothesized ...

  17. agent combination therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ASP and Planning, Jul-Aug 2003, Sydney, NICTA Third week (Chapter 4) The second part Zachmann, Gabriel 3 Combination therapy for manic phases Combination therapy for manic phases:...

  18. Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy

    E-Print Network [OSTI]

    Pallasch, Christian P.

    Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated malignancies. Here, we show that select microenvironments can underlie resistance to antibody-based therapy. Using ...

  19. Development of an interleukin 2 receptor targeted gene therapy vehicle 

    E-Print Network [OSTI]

    Wattanakaroon, Wanida

    2006-08-16T23:59:59.000Z

    The effectiveness of most chemotherapeutic regimens is limited by the toxicity of the therapy to normal healthy cells. Therapies to selectively modulate abnormal T cells bearing the interleukin 2 receptor (IL-2R) have been developed to treat...

  20. Computational aspects of treatment planning for neutron capture therapy

    E-Print Network [OSTI]

    Albritton, James Raymond, 1977-

    2010-01-01T23:59:59.000Z

    Boron Neutron Capture Therapy (BNCT) is a biochemically targeted form of binary radiation therapy that has the potential to deliver radiation to cancers with cellular dose selectivity. Accurate and efficient treatment ...

  1. From molecular changes to customised therapy A. Hemminki*,1

    E-Print Network [OSTI]

    Hemminki, Akseli

    and the Gene Therapy Center, University of Alabama at Birmingham, WTI #602, 1824 6th Ave S., Birmingham, AL

  2. The University of British Columbia | Department of Physical Therapy Strategic Plan 2010 2014 1 DEPARTMENT OF PHYSICAL THERAPY

    E-Print Network [OSTI]

    Michelson, David G.

    The University of British Columbia | Department of Physical Therapy Strategic Plan 2010 ­ 2014 1 DEPARTMENT OF PHYSICAL THERAPY UNIVERSITY OF BRITISH COLUMBIA STRATEGIC PLAN 20102014 development. 3. Faculty members teaching assignments. #12;The University of British Columbia | Department

  3. Radiation therapy of pediatric brain tumors : comparison of long-term health effects and costs between proton therapy and IMRT

    E-Print Network [OSTI]

    Vu, An T. (An Thien)

    2011-01-01T23:59:59.000Z

    Radiation therapy is an important component of pediatric brain tumor treatment. However, radiation-induced damage can lead to adverse long-term health effects. Proton therapy has the ability to reduce the dose delivered ...

  4. The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2015-01-01T23:59:59.000Z

    T. Photodynamic therapy: off-label and alternative use inreal-life practice of off-label photodynamic therapy using

  5. Mountain View Electric Association, Inc- Energy Efficiency Credit Program

    Broader source: Energy.gov [DOE]

    Mountain View Electric Association, Inc. (MVEA) and Tri-State Generation and Transmission Association Inc., MVEA’s power supplier, will pay credits to MVEA customers who install qualifying energy...

  6. DOE Zero Ready Home Case Study: Clifton View Homes, Kaltenbach...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    want to go anywhere else," said Clifton. Clifton, founder of Clifton View Homes, offers net zero energy homes and home designs. Clifton has been building high-performance homes...

  7. A Transformational View of Cartography W. R. Tobler

    E-Print Network [OSTI]

    Clarke, Keith

    A Transformational View of Cartography W. R. Tobler ABSTRACT. Cartographic transformations aliases are between points, lines, and areas. Substantive transformations occur in map interpolation transformational grammars, as originally devised for linguistics.2, 4 A similar, though less ambitious, attempt

  8. Sea Oil Field Satellite Monitoring: An Opera3onal View

    E-Print Network [OSTI]

    Kuligowski, Bob

    through oil drilling. It is refined and separated, most easily by boiling In the oil industry, the term "North Sea" o`en includes areasSea Oil Field Satellite Monitoring: An Opera3onal View Maurizio

  9. How can I view submitted materials? | OpenEI Community

    Open Energy Info (EERE)

    view submitted materials? Home > Groups > 2014 Geothermal Case Study Challenge Submitted by NickL on 6 May, 2014 - 07:41 1 answer Points: 0 For various reasons, you may want to...

  10. Plan-view Trajectory Estimation with Dense Stereo Background Models

    E-Print Network [OSTI]

    Darrell, T.

    2001-02-01T23:59:59.000Z

    In a known environment, objects may be tracked in multiple views using a set of back-ground models. Stereo-based models can be illumination-invariant, but often have undefined values which inevitably lead to foreground ...

  11. NEWS & VIEWS synchrotron or helium-lamp studies. But

    E-Print Network [OSTI]

    Loss, Daniel

    NEWS & VIEWS synchrotron or helium-lamp studies. But the low energy of the laser photons raises that of a conventional metal. The effects of projection have led to detailed quantitative insights into the properties

  12. axis view techniques: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 An Asymmetric, Energetic Type Ic Supernova Viewed Off-Axis, and a Link to Gamma-Ray Bursts Astrophysics (arXiv) Summary: Type Ic supernovae, the explosions following the...

  13. ViewDependent Refinement of Progressive Meshes Hugues Hoppe

    E-Print Network [OSTI]

    California at Berkeley, University of

    to these criteria. The algorithm exploits view coherence, supports frame rate regulation, and is found to require not contribute to the image (Figure 12a). While these faces are typically culled early in the rendering pipeline

  14. View-Dependent Refinement of Progressive Meshes Hugues Hoppe

    E-Print Network [OSTI]

    Cohen, Michael

    to these criteria. The algorithm exploits view coherence, supports frame rate regulation, and is found to require in the rendering pipeline, this processing incurs a cost. Similarly, it is often unnecessary to render faces

  15. June 2014 Most Viewed Documents for Fission And Nuclear Technologies...

    Office of Scientific and Technical Information (OSTI)

    Viewed Documents for Fission And Nuclear Technologies Behavior of spent nuclear fuel in water pool storage Johnson, A.B. Jr. (1977) 78 Estimation of gas leak rates through very...

  16. Challenges in Applying Formal Methods An SME View

    E-Print Network [OSTI]

    Southampton, University of

    Challenges in Applying Formal Methods An SME View Mathieu Clabaut Systerel, Aix-en-Provence, France classical B and event B to design safety related systems in an SME. 1 Activities Systerel is an SME doing

  17. A Narrower Spectrum for a Wider View of Matter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wider View of Matter July 9, 2014 Bookmark and Share Ultra-high-resolution dispersive optics of the new inelastic x-ray scattering (IXS) spectrometer (top) and IXS spectrum of...

  18. A Unified View on Speeded Categorization Hongbin Gu 1

    E-Print Network [OSTI]

    Ji, Chuanshu

    A Unified View on Speeded Categorization Hongbin Gu 1 Chuanshu Ji 2 1 Introduction The research of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; hongbin

  19. Development of AeroView: an interactive flow diagnostics laboratory

    E-Print Network [OSTI]

    Galls, Samuel Fernando

    1996-01-01T23:59:59.000Z

    This research includes the development of a set of experimental flow-diagnostics techniques for low speed aerodynamics applications and an interactive software for flow field data acquisition and presentation called AeroView. The data collection...

  20. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01T23:59:59.000Z

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  1. Biogas From Municipal WWTPs: Fuel Cells Viewed as a Value Proposition...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    From Municipal WWTPs: Fuel Cells Viewed as a Value Proposition Biogas From Municipal WWTPs: Fuel Cells Viewed as a Value Proposition Presentation about the value proposition for...

  2. Recent advances in neutron capture therapy (NCT)

    SciTech Connect (OSTI)

    Fairchild, R.G.

    1985-01-01T23:59:59.000Z

    The application of the /sup 10/B(n,..cap alpha..)/sup 7/Li reaction to cancer radiotherapy (Neutron Capture therapy, or NCT) has intrigued investigators since the discovery of the neutron. This paper briefly summarizes data describing recently developed boronated compounds with evident tumor specificity and extended biological half-lives. The implication of these compounds to NCT is evaluated in terms of Therapeutic Gain (TG). The optimization of NCT using band-pass filtered beams is described, again in terms of TG, and irradiation times with these less intense beams are estimated. 24 refs., 3 figs., 3 tabs.

  3. Gantry for medical particle therapy facility

    DOE Patents [OSTI]

    Trbojevic, Dejan (Wading River, NY)

    2012-05-08T23:59:59.000Z

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of fixed field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of fixed field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing fixed field magnets.

  4. COMPACT ACCELERATOR CONCEPT FOR PROTON THERAPY

    SciTech Connect (OSTI)

    Caporaso, G; Sampayan, S; Chen, Y; Harris, J; Hawkins, S; Holmes, C; Krogh, M; Nelson, S; Nunnally, W; Paul, A; Poole, B; Rhodes, M; Sanders, D; Selenes, K; Sullivan, J; Wang, L; Watson, J

    2006-08-18T23:59:59.000Z

    A new type of compact induction accelerator is under development at the Lawrence Livermore National Laboratory that promises to increase the average accelerating gradient by at least an order of magnitude over that of existing induction machines. The machine is based on the use of high gradient vacuum insulators, advanced dielectric materials and switches and is being developed as a compact flash x-ray radiography source. Research describing an extreme variant of this technology aimed at proton therapy for cancer will be presented.

  5. Gantry for medical particle therapy facility

    DOE Patents [OSTI]

    Trbojevic, Dejan

    2013-04-23T23:59:59.000Z

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of superconducting, variable field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of variable field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing variable field magnets.

  6. Metalloporphyrins and their uses as radiosensitizers for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2004-07-06T23:59:59.000Z

    The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

  7. View from the Bridge: Commercial Vehicle Perspective | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your DensityEnergy U.S.-China Electric Vehicle and03/02Report | DepartmentTRUVictor Der About Us VictorViewView

  8. antithyroid drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  9. antidiabetic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  10. antiretroviral drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  11. antipsychotic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  12. antiepileptic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  13. antiarrhythmic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  14. adhd drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  15. antihypertensive drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  16. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive...

  17. anticoagulant therapy case: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  18. anticoagulation therapy mr-tomographische: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  19. anticoagulation therapy elective: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  20. antiplatelet therapy i prevention: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  1. anticoagulant therapy inr: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  2. antibody prodrug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ION Antibody-based therapies for malaria Richard J. Pleass and tissue fluids, and can protect against malaria by binding and neutralizing malaria parasites of antibodies in the...

  3. Wind Energy Facilities and Residential Properties: The Effect of Proximity and View on Sales Prices

    E-Print Network [OSTI]

    Hoen, Ben

    2010-01-01T23:59:59.000Z

    Wind Energy Facilities and Residential Properties: The Effect of Proximity and View on Sales Prices *

  4. Methods for implementing microbeam radiation therapy

    DOE Patents [OSTI]

    Dilmanian, F. Avraham; Morris, Gerard M.; Hainfeld, James F.

    2007-03-20T23:59:59.000Z

    A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams/microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

  5. Fan-beam intensity modulated proton therapy

    SciTech Connect (OSTI)

    Hill, Patrick [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 (United States)] [Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 (United States); Westerly, David [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)] [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Mackie, Thomas [Medical Devices, Morgridge Institute for Research, University of Wisconsin, Madison, Wisconsin 53715 (United States)] [Medical Devices, Morgridge Institute for Research, University of Wisconsin, Madison, Wisconsin 53715 (United States)

    2013-11-15T23:59:59.000Z

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques.Methods: A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0–255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets.Results: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage. Overall, the sharp distal falloff of a proton depth-dose distribution was found to provide sufficient control over the dose distribution to meet objectives, even with coarse lateral resolution and channel widths as large as 2 cm. Treatment plans on both phantom and patient data show that dose conformity suffers when treatments are delivered from less than approximately ten angles. Treatment time for a sample prostate delivery is estimated to be on the order of 10 min, and neutron production is estimated to be comparable to that found for existing collimated systems.Conclusions: Fan beam proton therapy is a method of delivering intensity modulated proton therapy which may be employed as an alternative to magnetic scanning systems. A fan beam of protons can be created by a set of quadrupole magnets and modified by a dual-purpose range and intensity modulator. This can be used to deliver inversely planned treatments, with spot intensities optimized to meet user defined dose objectives. Additionally, the ability of a fan beam delivery system to effectively treat multiple beam spots simultaneously may provide advantages as compared to spot scanning deliveries.

  6. In all cases, ALOX5AP and its synonyms were highlighted automati-cally in each view. To highlight disease terms in these views, we

    E-Print Network [OSTI]

    Cai, Long

    the results easy to explore. The novo|seek search box interface allows the user to enter a term (or the production of substances that cause inflammation, such as leukotrienes1. When we entered ALOX5AP as a search a simple view (title, journal and author), a snippet view (a simple view and the search term with flanking

  7. View Management for Driver Assistance in an HMD

    E-Print Network [OSTI]

    cases. Nevertheless, an increasing number of companies have started to develop light- weight of (currently handheld) mobile augmented reality applications. For cars, this setup seems equally plausible factors need to be considered by future application developers. In view of this question we performed

  8. Analyzing and Visualizing Cosmological Simulations with ParaView

    SciTech Connect (OSTI)

    Woodring, Jonathan [Los Alamos National Laboratory (LANL); Heitmann, Katrin [ORNL; Ahrens, James P [ORNL; Fasel, Patricia [Los Alamos National Laboratory (LANL); Hsu, Chung-Hsing [ORNL; Habib, Salman [ORNL; Pope, Adrian [Los Alamos National Laboratory (LANL)

    2011-01-01T23:59:59.000Z

    The advent of large cosmological sky surveys - ushering in the era of precision cosmology - has been accompanied by ever larger cosmological simulations. The analysis of these simulations, which currently encompass tens of billions of particles and up to a trillion particles in the near future, is often as daunting as carrying out the simulations in the first place. Therefore, the development of very efficient analysis tools combining qualitative and quantitative capabilities is a matter of some urgency. In this paper, we introduce new analysis features implemented within ParaView, a fully parallel, open-source visualization toolkit, to analyze large N-body simulations. A major aspect of ParaView is that it can live and operate on the same machines and utilize the same parallel power as the simulation codes themselves. In addition, data movement is in a serious bottleneck now and will become even more of an issue in the future; an interactive visualization and analysis tool that can handle data in situ is fast becoming essential. The new features in ParaView include particle readers and a very efficient halo finder that identifies friends-of-friends halos and determines common halo properties, including spherical overdensity properties. In combination with many other functionalities already existing within ParaView, such as histogram routines or interfaces to programming languages like Python, this enhanced version enables fast, interactive, and convenient analyses of large cosmological simulations. In addition, development paths are available for future extensions.

  9. Viewable image size Max view area (W x H)

    E-Print Network [OSTI]

    Saskatchewan, University of

    standards Environmental Preset resolutions Presets / user settings Viewing adjustments Rotating screen768 WXGA+: 1440x900 1600x900 WSXGA+: 1680x1050 Standard presets: VGA/DisplayPort: 26; DVI-D: 25; user 90 degrees from landscape to portrait (requires image rotation support from graphics controller

  10. Viewable image size Max view area (W x H)

    E-Print Network [OSTI]

    Saskatchewan, University of

    standards Environmental Preset resolutions Presets / user settings Viewing adjustments Rotating screen: 1920x1200 Standard presets: 30; user settings: 20 Tilt: 30° back, 0° forward; lift: 4.3" (110mm rotation support from graphics controller) On screen display with digital user controls (8 languages

  11. Self-Calibration from Two Views Richard I. Hartley

    E-Print Network [OSTI]

    Hartley, Richard

    Self-Calibration from Two Views Richard I. Hartley G.E. CRD, Schenectady, NY, 12301. Email : hartley@crd.ge.com Abstract A new practical method is given for the self-calibration of a camera and calibration is computed from an analysis of point matches between the two images. The method requires

  12. Self-Calibration from Multiple Views with a Rotating Camera

    E-Print Network [OSTI]

    Hartley, Richard

    Self-Calibration from Multiple Views with a Rotating Camera Richard I. Hartley G.E. CRD, Schenectady, NY, 12301. Email : hartley@crd.ge.com Abstract. A new practical method is given for the self-calibration orientations of the camera and calibration is computed from an analysis of point matches between the images

  13. adaptive optics views: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    optics views First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Design of an Adaptive Scanning Optical...

  14. General view on nuclear fission Karl-Heinz Schmidt

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    General view on nuclear fission Karl-Heinz Schmidt Beatriz Jurado CENBG, CNRS/IN2 P3 Chemin du.amouroux@cea.fr 1 in2p3-00976648,version1-10Apr2014 #12;Abstract: A general approach to nuclear fission is described which ex- plains the complex appearance of fission observables by universal principles of theoretical

  15. Learning the Topology of Object Views Jan Wieghardt1

    E-Print Network [OSTI]

    Würtz, Rolf P.

    Malsburg2,3 1 SIEMENS AG, CT SE 1, Otto-Hahn-Ring 6, D-81730 M¨unchen, Germany jan.wieghardt@mchp.siemens such a representation by deriving transformations between the different views of a given object, so that they can be pa, we construct such a representation by deriving transformations between the different visual

  16. NEWS AND VIEWS Modeling gene expression control using Omes Law

    E-Print Network [OSTI]

    Nguyen, Dat H.

    NEWS AND VIEWS Modeling gene expression control using Omes Law Harmen J Bussemaker Department class of methods that fit simple mathematical models of transcription regulation to DNA microarray data factors (TFs) to specific sites in the genome is a crucial step in the molecular process controlling gene

  17. Home Timeslide View Flipcard Voice RecognitionApplication

    E-Print Network [OSTI]

    Sóbester, András

    Home Timeslide View Flipcard Voice RecognitionApplication Solar DefectAnalysis Search N O V E M B E EnergyPanels 4. The Future In Technology 5. Hands On Solar Training 6. Wind EnergySolutions ads by media R 1 0 , 2 0 Revolutionary ultrasonic nozzle can reduce water and energy used for cleaning by ten

  18. The view-based approach to dynamic inter-organizational

    E-Print Network [OSTI]

    Dustdar, Schahram

    The view-based approach to dynamic inter-organizational workflow cooperation Issam Chebbi, Samir Distributed Systems Group This paper presents a novel approach to inter-organizational workflow co- operation of workflows and their resources, thus providing powerful ways for inter- organizational workflow configuration

  19. Lithium Hexamethyldisilazide: A View of Lithium Ion Solvation

    E-Print Network [OSTI]

    Collum, David B.

    Lithium Hexamethyldisilazide: A View of Lithium Ion Solvation through a Glass-Bottom Boat BRETT L and reactivities, we were drawn to lithium hexamethyldisilazide (LiHMDS; (Me3Si)2NLi) by its promi- nence principles of lithium ion coordination chemistry.2 Understanding how solvation influences organolithium

  20. www.advmat.de www.MaterialsViews.com

    E-Print Network [OSTI]

    Hong, Soon Hyung

    by plasma- enhanced chemical vapor deposition. Methane (CH4) was used as the carbon source to synthesize. The strong protein-based adhesives found in marine mussel Mytilus edulis, provide an important insight for the solidification by oxidative chemical crosslinking.[21­24] From a chemical point of view, covalent crosslinking

  1. How species interact Altering the Standard View on Trophic Ecology

    E-Print Network [OSTI]

    Canet, Léonie

    How species interact Altering the Standard View on Trophic Ecology Roger Arditi and Lev R. Ginzburg, the French National Institute for Agricultural Research, in the research unit of Ecology and Evolution of ecology and evolution at Stony Brook University since 1977. He has published widely on theoretical

  2. View-Based Query Processing: On the Relationship Between Rewriting,

    E-Print Network [OSTI]

    Calvanese, Diego

    amounts to computing the tuples satisfying the query in all databases consistent with the views. Rewriting in the setting of semistructured databases, and in particular for the basic query class in this setting, i-0311326, IIS-9908435, IIS-9978135, EIA-0086264, and ANI-0216467, by US-Israel BSF grant 9800096, by Texas

  3. The Once and Future Warm Earth: A Paleoceanographic View

    E-Print Network [OSTI]

    Sukop, Mike

    The Once and Future Warm Earth: A Paleoceanographic View Dr. Ted C. Moore, Jr., University of Michigan Predictions of climatic warming in the near future, if true, will approximate the very warm--and ended. In the early and mid Eocene the Arctic Ocean was ice-free and subtropical flora and fauna were

  4. news and views nucleotide binds to the polymerase and

    E-Print Network [OSTI]

    Schedl, Paul

    news and views nucleotide binds to the polymerase and before it is incorporated into DNA. Recent structures of several structurally diverse DNA polymerases complexed to DNA and nucleotide substrates have shown that their active sites adopt a closed conforma- tion upon binding to the correct nucleotide12

  5. Multiple Field of View MR Fluoroscopy Pelin Aksit,1

    E-Print Network [OSTI]

    Atalar, Ergin

    Multiple Field of View MR Fluoroscopy Pelin Aksit,1 J. Andrew Derbyshire,2 Jean-Michel Serfaty,1 by several investigators (1­ 8). Intravascular MR compares favorably with other clini- cal diagnostic methods and Ergin Atalar1* This work describes a real-time imaging and visualization tech- nique that allows

  6. NEWS & VIEWS X-RaY oPtiCS

    E-Print Network [OSTI]

    Loss, Daniel

    NEWS & VIEWS X-RaY oPtiCS Clarity through a keyhole Janos Hajdu1,2 & Filipe R. n. C. maia2 are at 1 Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, 2575 Sand Hill Road, Menlo, as it does in conventional crystallography, but only on the wavelength used, the extent of ionization damage

  7. APOLLO OVER THE MOON A View From Orbit

    E-Print Network [OSTI]

    Rathbun, Julie A.

    #12;s Near ride #12;APOLLO OVER THE MOON A View From Orbit #12;#12;NASA SP-362 APOLLO OVER THE MOO Catalogingin Publication Data Main entry under title: Apollo over the moon. (NASA SP ;362) Bibliography: p. 251. 1. Moon-Photographs from space. 2. Project Apollo. I. Masursky, Harold, 1922- 11. Colton, George

  8. An Integrated View of Security Analysis and Performance Evaluation

    E-Print Network [OSTI]

    Aldini, Alessandro

    An Integrated View of Security Analysis and Performance Evaluation: Trading QoS with Covert Channel@sti.uniurb.it Abstract. Security analysis and performance evaluation are two funda- mental activities in the system. This is accomplished by proposing a tool-supported methodology that combines noninterference-based security analysis

  9. Proton Therapy Coverage for Prostate Cancer Treatment

    SciTech Connect (OSTI)

    Vargas, Carlos [University of Florida Proton Therapy Institute, Jacksonville, FL (United States); Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States)], E-mail: c2002@ufl.edu; Wagner, Marcus; Mahajan, Chaitali [University of Florida Proton Therapy Institute, Jacksonville, FL (United States); Indelicato, Daniel [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States); Fryer, Amber; Falchook, Aaron; Horne, David C.; Chellini, Angela; McKenzie, Craig C.; Lawlor, Paula C.; Li Zuofeng; Lin Liyong; Keole, Sameer [University of Florida Proton Therapy Institute, Jacksonville, FL (United States)

    2008-04-01T23:59:59.000Z

    Purpose: To determine the impact of prostate motion on dose coverage in proton therapy. Methods and Materials: A total of 120 prostate positions were analyzed on 10 treatment plans for 10 prostate patients treated using our low-risk proton therapy prostate protocol (University of Florida Proton Therapy Institute 001). Computed tomography and magnetic resonance imaging T{sub 2}-weighted turbo spin-echo scans were registered for all cases. The planning target volume included the prostate with a 5-mm axial and 8-mm superoinferior expansion. The prostate was repositioned using 5- and 10-mm one-dimensional vectors and 10-mm multidimensional vectors (Points A-D). The beam was realigned for the 5- and 10-mm displacements. The prescription dose was 78 Gy equivalent (GE). Results: The mean percentage of rectum receiving 70 Gy (V{sub 70}) was 7.9%, the bladder V{sub 70} was 14.0%, and the femoral head/neck V{sub 50} was 0.1%, and the mean pelvic dose was 4.6 GE. The percentage of prostate receiving 78 Gy (V{sub 78}) with the 5-mm movements changed by -0.2% (range, 0.006-0.5%, p > 0.7). However, the prostate V{sub 78} after a 10-mm displacement changed significantly (p < 0.003) with different movements: 3.4% (superior), -5.6% (inferior), and -10.2% (posterior). The corresponding minimal doses were also reduced: 4.5 GE, -4.7 GE, and -11.7 GE (p {<=} 0.003). For displacement points A-D, the clinical target volume V{sub 78} coverage had a large and significant reduction of 17.4% (range, 13.5-17.4%, p < 0.001) in V{sub 78} coverage of the clinical target volume. The minimal prostate dose was reduced 33% (25.8 GE), on average, for Points A-D. The prostate minimal dose improved from 69.3 GE to 78.2 GE (p < 0.001) with realignment for 10-mm movements. Conclusion: The good dose coverage and low normal doses achieved for the initial plan was maintained with movements of {<=}5 mm. Beam realignment improved coverage for 10-mm displacements.

  10. Intensity Modulated Beam Radiation Therapy Dose Optimization with Multiobjective

    E-Print Network [OSTI]

    Coello, Carlos A. Coello

    Intensity Modulated Beam Radiation Therapy Dose Optimization with Multiobjective Evolutionary will be di- agnosed with cancer. Half of these will be treated with radiation therapy [1]. In teletherapy or external radiotherapy beams of penetrating radiation are directed at the tumor. Along their path through

  11. Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*,

    E-Print Network [OSTI]

    Hemminki, Akseli

    ; gene therapy. INTRODUCTION Ovarian cancer afflicts more than 25,000 women annually in the United States Paz, Madrid, Spain Received November 10, 2000 Ovarian carcinoma is a leading cause of cancer death in women. Though advances in conventional therapies have been achieved, long-term survival rates for most

  12. ALLIED HEALTH Physical & Occupational Therapy, Cytotechnology, Dental Hygiene,

    E-Print Network [OSTI]

    Kaminsky, Werner

    to physical therapy programs. Obtain knowledge of several basic sciences including anatomy, physiology Physical therapy involves treatment through physical means for people disabled by illness, accident disabilities. Clinical Practice Acute care Neuro-rehab Out-patient Management Education Research Consultation

  13. Boron containing compounds and their preparation and use in neutron capture therapy

    DOE Patents [OSTI]

    Gabel, Detlef (Bremen, DE)

    1992-01-01T23:59:59.000Z

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  14. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOE Patents [OSTI]

    Gabel, Detlef (Bremen, DE)

    1991-01-01T23:59:59.000Z

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  15. Osteoporosis Therapies: Evidence from Health-Care Databases and Observational Population Studies

    E-Print Network [OSTI]

    Silverman, Stuart L.

    2010-01-01T23:59:59.000Z

    for the S. L. Silverman: Osteoporosis Therapies Fig. 2010-9400-1 REVIEW Osteoporosis Therapies: Evidence fromSpringerlink.com Abstract Osteoporosis is a well-recognized

  16. Whole-Pelvis Radiotherapy in Combination With Interstitial Brachytherapy: Does Coverage of the Pelvic Lymph Nodes Improve Treatment Outcome in High-Risk Prostate Cancer?

    SciTech Connect (OSTI)

    Bittner, Nathan [Tacoma/Valley Radiation Oncology Centers, Tacoma, Washington (United States); Merrick, Gregory S., E-mail: gmerrick@UrologicResearchInstitute.or [Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, West Virginia (United States); Wallner, Kent E. [Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, Washington (United States); Butler, Wayne M.; Galbreath, Robert [Schiffler Cancer Center and Wheeling Jesuit University, Wheeling, West Virginia (United States); Adamovich, Edward [Wheeling Hospital, Department of Pathology, Wheeling, West Virginia (United States)

    2010-03-15T23:59:59.000Z

    Purpose: To compare biochemical progression-free survival (bPFS), cause-specific survival (CSS), and overall survival (OS) rates among high-risk prostate cancer patients treated with brachytherapy and supplemental external beam radiation (EBRT) using either a mini-pelvis (MP) or a whole-pelvis (WP) field. Methods and Materials: From May 1995 to October 2005, 186 high-risk prostate cancer patients were treated with brachytherapy and EBRT with or without androgen-deprivation therapy (ADT). High-risk prostate cancer was defined as a Gleason score of >=8 and/or a prostate-specific antigen (PSA) concentration of >=20 ng/ml. Results: With a median follow-up of 6.7 years, the 10-year bPFS, CSS, and OS rates for the WP vs. the MP arms were 91.7% vs. 84.4% (p = 0.126), 95.5% vs. 92.6% (p = 0.515), and 79.5% vs. 67.1% (p = 0.721), respectively. Among those patients who received ADT, the 10-year bPFS, CSS, and OS rates for the WP vs. the MP arms were 93.6% vs. 90.1% (p = 0.413), 94.2% vs. 96.0% (p = 0.927), and 73.7% vs. 70.2% (p = 0.030), respectively. Among those patients who did not receive ADT, the 10-year bPFS, CSS, and OS rates for the WP vs. the MP arms were 82.4% vs. 75.0% (p = 0.639), 100% vs. 88% (p = 0.198), and 87.5% vs. 58.8% (p = 0.030), respectively. Based on multivariate analysis, none of the evaluated parameters predicted for CSS, while bPFS was best predicted by ADT and percent positive biopsy results. OS was best predicted by age and percent positive biopsy results. Conclusions: For high-risk prostate cancer patients receiving brachytherapy, there is a nonsignificant trend toward improved bPFS, CSS, and OS rates when brachytherapy is given with WPRT. This trend is most apparent among ADT-naive patients, for whom a significant improvement in OS was observed.

  17. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States)] [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States); Ann Stepp, Mary [Medical School, George Washington University, Washington DC 20052 (United States)] [Medical School, George Washington University, Washington DC 20052 (United States); Srinivasan, Priya; Sandler, Anthony [Childrens National Medical Center, Washington DC 20010 (United States)] [Childrens National Medical Center, Washington DC 20010 (United States); Trink, Barry [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)] [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)

    2013-05-15T23:59:59.000Z

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  18. Interaction of hyperthermia and photoradiation therapy

    SciTech Connect (OSTI)

    Waldow, S.M.; Dougherty, T.J.

    1984-02-01T23:59:59.000Z

    Local microwave hyperthermia (2450 MHz) was applied to axillary implants of the SMT-F mammary carcinoma in mice in combination with photoradiation therapy (PRT) in an attempt to determine if the two modalities interact. When 40.5/sup 0/C was applied for 30 min immediately prior to or immediately following PRT enhancement of tumor response over that of PRT alone was seen as judged by lack of tumor regrowth (35 days or longer after treatment). A temperature of 41.5/sup 0/C applied for 30 min immediately following the 30-min PRT treatment produced a result slightly greater than that seen at 40.5/sup 0/C. When a temperature of 44.5/sup 0/C for 30 min was applied immediately following PRT, a substantial enhancement of tumor control at 35 days post-treatment was found. These results suggest that tumor response to PRT is enhanced by both a sublethal hyperthermic treatment (40.5/sup 0/C, 41.5/sup 0/C) and a moderately lethal heat treatment (44.5/sup 0/C) given for a short duration, when applied immediately before or after photoradiation.

  19. Interaction of hyperthermia and photoradiation therapy

    SciTech Connect (OSTI)

    Waldow, S.M.; Dougherty, T.J.

    1984-02-01T23:59:59.000Z

    Local microwave hyperthermia (2450 MHz) was applied to auxillary implants of the SMT-F mammary carcinoma in mice in combination with photoradiation therapy (PRT) in an attempt to determine if the two modalities interact. When 40.5/sup 0/C was applied for 30 min immediately prior to or immediately following PRT enhancement of tumor response over that of PRT alone was seen as judged by lack of tumor regrowth (35 days or longer after treatment). A temperature of 41.5/sup 0/C applied for 30 min immediately following the 30-min PRT treatment produced a result slightly greater than that seen at 40.5/sup 0/C. When a temperature of 44.5/sup 0/C for 30 min was applied immediately following PRT, a substantial enhancement of tumor control at 35 days post-treatment was found. These results suggest that tumor response to PRT is enhanced by both a sublethal hyperthermic treatment (40.5/sup 0/C, 41.5/sup 0/C) and a moderately lethal heat treatment (44.5/sup 0/C) given for a short duration, when applied immediately before or after photoradiation.

  20. Nepal: Western Views of the Maoist Insurgency and the Royal Takeover

    E-Print Network [OSTI]

    Burleigh, Peter

    2005-01-01T23:59:59.000Z

    Governance Presentation No. 2 Nepal: Western Views of theworkingpapers/index.html NEPAL: Western Views of the Maoistof the Maoist revolt in Nepal in 1996, there have been a

  1. Travel, work, and telecommunications: a view of the electronics revolution and its potential impacts

    E-Print Network [OSTI]

    Garrison, William L.; Deakin, Elizabeth

    2006-01-01T23:59:59.000Z

    TELECOMMUNICATIONS: A VIEW OF THE ELECTRONICS REVOLUTION ANDtechnologies and other electronics innovations ontelecommunications and other electronics innovations on the

  2. Hepatocellular Carcinoma Radiation Therapy: Review of Evidence and Future Opportunities

    SciTech Connect (OSTI)

    Klein, Jonathan [Department of Radiation Oncology, Princess Margaret Hospital/University of Toronto, Toronto, Ontario (Canada); Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.ca [Department of Radiation Oncology, Princess Margaret Hospital/University of Toronto, Toronto, Ontario (Canada)

    2013-09-01T23:59:59.000Z

    Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Curative therapy is not an option for most patients, often because of underlying liver disease. Experience in radiation therapy (RT) for HCC is rapidly increasing. Conformal RT can deliver tumoricidal doses to focal HCC with low rates of toxicity and sustained local control in HCC unsuitable for other locoregional treatments. Stereotactic body RT and particle therapy have been used with long-term control in early HCC or as a bridge to liver transplant. RT has also been effective in treating HCC with portal venous thrombosis. Patients with impaired liver function and extensive disease are at increased risk of toxicity and recurrence. More research on how to combine RT with other standard and novel therapies is warranted. Randomized trials are also needed before RT will be generally accepted as a treatment option for HCC. This review discusses the current state of the literature and opportunities for future research.

  3. Effects of Low Level Laser Therapy on Orthodontic Pain 

    E-Print Network [OSTI]

    Buchwald, Bradley

    2014-04-28T23:59:59.000Z

    Purpose: To determine the effectiveness of low level laser therapy applied extra orally on the reduction of orthodontic pain. Materials and Methods: Sixty dental students were voluntarily recruited for this randomized, double-blinded, placebo...

  4. A novel nanodelivery system for combination tumor therapy

    E-Print Network [OSTI]

    Eavarone, David A. (David Alan)

    2004-01-01T23:59:59.000Z

    Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in ...

  5. HEALTHCARE SCIENCES Physical & Occupational Therapy, Cytotechnology, Dental Hygiene,

    E-Print Network [OSTI]

    New Hampshire, University of

    programs. Obtain knowledge of several basic sciences includ- ing anatomy, physiology, biology, chemistry means for people disabled by illness, accident, or congenital handicap. Physical therapy seeks Neuro-rehab Out-patient Management Education Research Consultation Specialties Include: Pediatrics

  6. An Examination of Music Therapy with Adolescent Populations

    E-Print Network [OSTI]

    Seagren, Stephanie

    2009-05-01T23:59:59.000Z

    , leading to impulsive and disorganized behavior" (Alloy et al., 2005, G-1). Hallahan 12 and Kauffman (2003) noted that the American Psychiatric Association recognizes subdivisions of ADHD including: "1) ADHD, Predominantly Inattentive Type, 2) ADHD... to their full potential. Direct intervention may include 2 various forms of services or therapies, including music therapy. Over the years music therapists and researchers have examined the use of music with various adolescent populations (see Appendix A...

  7. View Maintenance in a Warehousing Environment Yue Zhuge, Hector Garcia-Molina, Joachim Hammer, Jennifer Widom

    E-Print Network [OSTI]

    Hammer, Joachim

    information, avail- able for queries and analysis (e.g., decision support, or data mining) IK93]. As relevantView Maintenance in a Warehousing Environment Yue Zhuge, Hector Garcia-Molina, Joachim Hammer are updated. This view maintenance prob- lem di ers from the traditional one in that the view de nition

  8. GenomeView: a next-generation genome browser Thomas Abeel1,2,3,

    E-Print Network [OSTI]

    Gent, Universiteit

    GenomeView: a next-generation genome browser Thomas Abeel1,2,3, *, Thomas Van Parys1,2 , Yvan Saeys GenomeView, a stand-alone genome browser specifically designed to visualize and manipulate a multitude of genomics data. GenomeView enables users to dynamically browse high volumes of aligned short-read data

  9. ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM

    E-Print Network [OSTI]

    Schaettler, Heinz

    ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM URSZULA LEDZEWICZ AND HEINZ SCH¨ATTLER Abstract. Anti-angiogenic therapy is a novel treatment approach in cancer therapy. Key words. optimal control, geometric methods, cancer treatment, anti-angiogenic therapy AMS subject

  10. Ground control failures. A pictorial view of case studies

    SciTech Connect (OSTI)

    Peng, S.S.

    2007-07-01T23:59:59.000Z

    The book shows, in pictorial views, many forms and/or stages of types of failures in mines, for instance, cutter, roof falls, and cribs. In each case, the year of occurrence is stated in the beginning so that the environment or technological background under which it occurred are reflected. The narrative than begins with the mining and geological conditions, followed by a description of the ground control problems and recommended solutions and results, if any. The sections cover failure of pillars, roof falls, longwall, roof bolting, multiple-seam mining, floor heave, longwall, flooding and weathering of coal, old workings, and shortwall and thin-seam plow longwall.

  11. Prairie View A&M University Whole Campus Energy Analysis

    E-Print Network [OSTI]

    Haberl, J. S.; Claridge, D. E.; Turner, W. D.

    1991-01-01T23:59:59.000Z

    the guaranteed-savings energy management program at the Prairie View Campus. The two primary findings are as follows: (1) Savings to date. The current (April 1990) calculated guaranteed savings equal or exceed the monthly contracted savings rate. Electricity... consumption has decreased sharply since April 1987. Natural gas usage, and electric demand have also decreased significantly. The savings began to appear in October of 1987 at a rate of about $5,000 per month. These savings grew at a steady pace for the next...

  12. Chevy Chase View, Maryland: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand JumpConceptual Model, click here.Telluric SurveyChelanVermont: EnergyView, Maryland: Energy Resources

  13. Skyline View, Pennsylvania: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt LtdShawangunk, New York:SiG SolarSkykomish, Washington: Energy ResourcesView,

  14. A View from the Bridge - DOE Perspective | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015ofDepartmentDepartment of Energy ThisThisthe National EnergyLookBroad view

  15. LabVIEW Core 2 Course | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5 - -/e),,s -LabgrantsLab team makesLab'sLabVIEW

  16. Prairie View Gas Recovery Biomass Facility | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal PwerPerkins County, Nebraska: EnergyPiratiniEdwards,PoseyPoudrePowers EnergyCityPrairieRose,View

  17. Logan View Public Schools Wind Project | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOf KilaueaInformation Other AlternativePark,CedarPowerView Public

  18. Mountain View, California: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup |JilinLu anMicrogreenMoon LakeMountain Electric Coop, IncView,

  19. OpenEI:Neutral point of view | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup |JilinLuOpenNorthOlympia Green FuelsperCivicVersionNeutral point of view

  20. Better Buildings Network View | April 2014 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China U.S. Department ofJune 2, 2015Energyon23264Compare energy use byNew1Network View

  1. Bay View, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:EzfeedflagBiomass Conversions IncBay County, Florida: Energy Resources JumpHill,250986°,View,

  2. A View from the Bridge | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1 A Strategic Framework for SMRA View from the Bridge - DOEThis

  3. A View from the Bridge | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1 A Strategic Framework for SMRA View from the Bridge - DOEThisOn-

  4. A View from the Bridge | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1 A Strategic Framework for SMRA View from the Bridge -

  5. Forest View, Illinois: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdf Jump to:ar-80m.pdfFillmoreGabbs ValleyCity, Florida:Oklahoma:Forest View,

  6. Valley View, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTown of Ladoga,planning methodologies andVacant Jump669°,Hill, NorthPark,View,

  7. A hardware investigation of robotic SPECT for functional and molecular imaging onboard radiation therapy systems

    SciTech Connect (OSTI)

    Yan, Susu, E-mail: susu.yan@duke.edu; Tough, MengHeng [Medical Physics Graduate Program, Duke University, Durham, North Carolina 27710 (United States); Bowsher, James; Yin, Fang-Fang [Medical Physics Graduate Program, Duke University, Durham, North Carolina 27710 and Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Cheng, Lin [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710 (United States)

    2014-11-01T23:59:59.000Z

    Purpose: To construct a robotic SPECT system and to demonstrate its capability to image a thorax phantom on a radiation therapy flat-top couch, as a step toward onboard functional and molecular imaging in radiation therapy. Methods: A robotic SPECT imaging system was constructed utilizing a gamma camera detector (Digirad 2020tc) and a robot (KUKA KR150 L110 robot). An imaging study was performed with a phantom (PET CT Phantom{sup TM}), which includes five spheres of 10, 13, 17, 22, and 28 mm diameters. The phantom was placed on a flat-top couch. SPECT projections were acquired either with a parallel-hole collimator or a single-pinhole collimator, both without background in the phantom and with background at 1/10th the sphere activity concentration. The imaging trajectories of parallel-hole and pinhole collimated detectors spanned 180° and 228°, respectively. The pinhole detector viewed an off-centered spherical common volume which encompassed the 28 and 22 mm spheres. The common volume for parallel-hole system was centered at the phantom which encompassed all five spheres in the phantom. The maneuverability of the robotic system was tested by navigating the detector to trace the phantom and flat-top table while avoiding collision and maintaining the closest possible proximity to the common volume. The robot base and tool coordinates were used for image reconstruction. Results: The robotic SPECT system was able to maneuver parallel-hole and pinhole collimated SPECT detectors in close proximity to the phantom, minimizing impact of the flat-top couch on detector radius of rotation. Without background, all five spheres were visible in the reconstructed parallel-hole image, while four spheres, all except the smallest one, were visible in the reconstructed pinhole image. With background, three spheres of 17, 22, and 28 mm diameters were readily observed with the parallel-hole imaging, and the targeted spheres (22 and 28 mm diameters) were readily observed in the pinhole region-of-interest imaging. Conclusions: Onboard SPECT could be achieved by a robot maneuvering a SPECT detector about patients in position for radiation therapy on a flat-top couch. The robot inherent coordinate frames could be an effective means to estimate detector pose for use in SPECT image reconstruction.

  8. The effects of interstitial atoms H and B on magnetic properties and magnetocaloric effect in LaFe{sub 11.5}Al{sub 1.5} compound

    SciTech Connect (OSTI)

    Zhang, D. K. [College of Applied Sciences, Beijing University of Technology, Beijing 100124 (China); College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China); Zhao, J. L., E-mail: zhaojinliang@bjut.edu.cn [College of Applied Sciences, Beijing University of Technology, Beijing 100124 (China); Shen, J. [Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190 (China); Zhang, H. G.; Yue, M. [College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China)

    2014-05-14T23:59:59.000Z

    The changes in magnetic properties of LaFe{sub 11.5}Al{sub 1.5}H{sub x} and LaFe{sub 11.5}Al{sub 1.5}B{sub y} have been investigated. By introducing interstitial atoms H or B, the magnetic ground state is changed from the antiferromagnetic to the ferromagnetic state, accompanied by significant increases in the saturated magnetization (Ms) and the Curie temperature (T{sub C}). An attractive feature is that the magnetic transition from the second-order to the weakly first-order with increasing hydrogen content compared to the magnetic transition from the weakly first-order to the second-order with increasing boron content. The maximum magnetic entropy change (??S{sub M}) under a field change of 0–5?T increases from 10.1?J/kg?·?K for hydrogen content x?=?0.12 to 12.3?J/kg?·?K for x?=?1.3, while decreases from 9.6?J/kg?·?K for boron content y?=?0.1 to 9.2?J/kg?·?K for y?=?0.3.

  9. Robust optimization of intensity modulated proton therapy

    SciTech Connect (OSTI)

    Liu Wei; Zhang Xiaodong; Li Yupeng; Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2012-02-15T23:59:59.000Z

    Purpose: Intensity modulated proton therapy (IMPT) is highly sensitive to range uncertainties and uncertainties caused by setup variation. The conventional inverse treatment planning of IMPT optimized based on the planning target volume (PTV) is not often sufficient to ensure robustness of treatment plans. In this paper, a method that takes the uncertainties into account during plan optimization is used to mitigate the influence of uncertainties in IMPT. Methods: The authors use the so-called ''worst-case robust optimization'' to render IMPT plans robust in the face of uncertainties. For each iteration, nine different dose distributions are computed--one each for {+-} setup uncertainties along anteroposterior (A-P), lateral (R-L) and superior-inferior (S-I) directions, for {+-} range uncertainty, and the nominal dose distribution. The worst-case dose distribution is obtained by assigning the lowest dose among the nine doses to each voxel in the clinical target volume (CTV) and the highest dose to each voxel outside the CTV. Conceptually, the use of worst-case dose distribution is similar to the dose distribution achieved based on the use of PTV in traditional planning. The objective function value for a given iteration is computed using this worst-case dose distribution. The objective function used has been extended to further constrain the target dose inhomogeneity. Results: The worst-case robust optimization method is applied to a lung case, a skull base case, and a prostate case. Compared with IMPT plans optimized using conventional methods based on the PTV, our method yields plans that are considerably less sensitive to range and setup uncertainties. An interesting finding of the work presented here is that, in addition to reducing sensitivity to uncertainties, robust optimization also leads to improved optimality of treatment plans compared to the PTV-based optimization. This is reflected in reduction in plan scores and in the lower normal tissue doses for the same coverage of the target volume when subjected to uncertainties. Conclusions: The authors find that the worst-case robust optimization provides robust target coverage without sacrificing, and possibly even improving, the sparing of normal tissues. Our results demonstrate the importance of robust optimization. The authors assert that all IMPT plans should be robustly optimized.

  10. Pelvic Normal Tissue Contouring Guidelines for Radiation Therapy: A Radiation Therapy Oncology Group Consensus Panel Atlas

    SciTech Connect (OSTI)

    Gay, Hiram A., E-mail: hgay@radonc.wustl.edu [Washington University School of Medicine, St Louis, MO (United States); Barthold, H. Joseph [Commonwealth Hematology and Oncology, Weymouth, MA (United States); Beth Israel Deaconess Medical Center, Boston, MA (Israel); O'Meara, Elizabeth [Radiation Therapy Oncology Group, Philadelphia, PA (United States); Bosch, Walter R. [Washington University School of Medicine, St Louis, MO (United States); El Naqa, Issam [Department of Radiation Oncology, McGill University Health Center, Montreal, Quebec (Canada); Al-Lozi, Rawan [Washington University School of Medicine, St Louis, MO (United States); Rosenthal, Seth A. [Radiation Oncology Centers, Radiological Associates of Sacramento, Sacramento, CA (United States); Lawton, Colleen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Lee, W. Robert [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Sandler, Howard [Cedars-Sinai Medical Center, Los Angeles, CA (United States); Zietman, Anthony [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States); Myerson, Robert [Washington University School of Medicine, St Louis, MO (United States); Dawson, Laura A. [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Willett, Christopher [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Kachnic, Lisa A. [Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, MA (United States); Jhingran, Anuja [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Portelance, Lorraine [University of Miami, Miami, FL (United States); Ryu, Janice [Radiation Oncology Centers, Radiological Associates of Sacramento, Sacramento, CA (United States); and others

    2012-07-01T23:59:59.000Z

    Purpose: To define a male and female pelvic normal tissue contouring atlas for Radiation Therapy Oncology Group (RTOG) trials. Methods and Materials: One male pelvis computed tomography (CT) data set and one female pelvis CT data set were shared via the Image-Guided Therapy QA Center. A total of 16 radiation oncologists participated. The following organs at risk were contoured in both CT sets: anus, anorectum, rectum (gastrointestinal and genitourinary definitions), bowel NOS (not otherwise specified), small bowel, large bowel, and proximal femurs. The following were contoured in the male set only: bladder, prostate, seminal vesicles, and penile bulb. The following were contoured in the female set only: uterus, cervix, and ovaries. A computer program used the binomial distribution to generate 95% group consensus contours. These contours and definitions were then reviewed by the group and modified. Results: The panel achieved consensus definitions for pelvic normal tissue contouring in RTOG trials with these standardized names: Rectum, AnoRectum, SmallBowel, Colon, BowelBag, Bladder, UteroCervix, Adnexa{sub R}, Adnexa{sub L}, Prostate, SeminalVesc, PenileBulb, Femur{sub R}, and Femur{sub L}. Two additional normal structures whose purpose is to serve as targets in anal and rectal cancer were defined: AnoRectumSig and Mesorectum. Detailed target volume contouring guidelines and images are discussed. Conclusions: Consensus guidelines for pelvic normal tissue contouring were reached and are available as a CT image atlas on the RTOG Web site. This will allow uniformity in defining normal tissues for clinical trials delivering pelvic radiation and will facilitate future normal tissue complication research.

  11. High resolution ion Doppler spectroscopy at Prairie View Rotamak

    SciTech Connect (OSTI)

    Houshmandyar, Saeid; Yang Xiaokang [Solar Observatory Department, Prairie View A and M University, Prairie View, Texas 77446 (United States); Magee, Richard [Department of Physics, West Virginia University, Morgantown, West Virginia 26506 (United States)

    2012-10-15T23:59:59.000Z

    A fast ion Doppler spectroscopy (IDS) diagnostic system is installed on the Prairie View Rotamak to measure ion temperature and plasma flow. The diagnostic employs a single channel photomultiplier tube and a Jarrell-Ash 50 monochromator with a diffraction grating line density of 1180 lines/mm, which allows for first order spectra of 200-600 nm. The motorized gear of the monochromator allows spectral resolution of 0.01 nm. Equal IDS measurements are observed for various impurity emission lines of which carbon lines exhibit stronger intensities. Furthermore, the diagnostics is examined in an experiment where plasma experiences sudden disruption and quick recovery. In this case, the IDS measurements show {approx}130% increase in ion temperature. Flow measurements are shown to be consistent with plasma rotation.

  12. Development of a fast neutron therapy beam placement film technique

    E-Print Network [OSTI]

    Baron, Robert Layton

    1971-01-01T23:59:59.000Z

    used are surgery and radiotherapy. High energy X rays and gamma rays are most often used when radio- therapy is required, but new interest in the use of other types of radiation has recently been generated. One of the first characteristics... of neutron radiation to be noted by Chadwick in 1932 was its ability to penetrate matter in manner similar to X rays (2). Although the results of Stone and his colleagues (3-5) caused Stone to recommend that neutrons not be used in cancer therapy, more...

  13. Selecting renal replacement therapies: what do African American and non-African American patients and their families think others should know? A mixed methods study

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    making about renal replacement therapies. Qual Health ResOpen Access Selecting renal replacement therapies: what doneed to inform renal replacement therapy (RRT) decisions.

  14. Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

    SciTech Connect (OSTI)

    Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Department of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, Texas 75390 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)

    2012-01-15T23:59:59.000Z

    Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment delivery times.

  15. Overview of Light-Ion Beam Therapy

    SciTech Connect (OSTI)

    Chu, William T.

    2006-03-16T23:59:59.000Z

    In 1930, Ernest Orlando Lawrence at the University of California at Berkeley invented the cyclotron. One of his students, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80 keV using less than 1 kV on a semi-circular accelerating electrode, now called the ''dee''. Soon after, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. In 1939, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. Just before WWII, Lawrence designed a 184-inch cyclotron, but the war prevented the building of this machine. Immediately after the war ended, the Veksler-McMillan principle of phase stability was put forward, which enabled the transformation of conventional cyclotrons to successful synchrocyclotrons. When completed, the 184-Inch Synchrocyclotron produced 340-MeV protons. Following it, more modern synchrocyclotrons were built around the globe, and the synchrocyclotrons in Berkeley and Uppsala, together with the Harvard cyclotron, would perform pioneering work in treatment of human cancer using accelerated hadrons (protons and light ions). When the 184-Inch Synchrocyclotron was built, Lawrence asked Robert Wilson, one of his former graduate students, to look into the shielding requirements for of the new accelerator. Wilson soon realized that the 184-Inch would produce a copious number of protons and other light ions that had enough energy to penetrate human body, and could be used for treatment of deep-seated diseases. Realizing the advantages of delivering a larger dose in the Bragg peak when placed inside deep-seated tumors, he published in a medical journal a seminal paper on the rationale to use accelerated protons and light ions for treatment of human cancer. The precise dose localization provided by protons and light ions means lower doses to normal tissues adjacent to the treatment volume compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers between 6 and 18, at energies that permitted the initiation of several biological studies. It is worth noting that when th

  16. Report of Energy Efficiency Study and Metering/Utilities Profile for Electricity Deregulation at Prairie View A&M University (PVAMU) Prairie View, Texas

    E-Print Network [OSTI]

    Zhu, Y.; Claridge, D. E.; Giebler, T.; Abushakra, B.; Turner, W. D.

    1999-01-01T23:59:59.000Z

    The physical plant director and staff at Prairie View A&M University (PVAMU) do a good job of maintaining PVAMU facilities and keeping expenses down. During our visit, however, we were able to identify several opportunities for improving energy...

  17. antibody therapy with rituximab. Although rituximab has gained increasing

    E-Print Network [OSTI]

    Abecasis, Goncalo

    -associated lymphoid tissue lymphoma showing the regression by Helicobacter pylori eradication therapy. Br J Haematol after treatment for Helicobacter pylori. Lancet 1996;348:268­9. 10. Ferreri AJ, Ponzoni M, Viale E, et al. Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa

  18. arterial infusion therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    arterial infusion therapy First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 STANFORD REDWOOD CITY...

  19. Verifying Therapy Safety Interlock System with SPIN Motlatsi Seotsanyana1

    E-Print Network [OSTI]

    Geldenhuys, Jaco

    , air traffic and space vehicle control systems, nuclear power plant safety control systems, medical as banking systems) to embedded environments (such as nuclear power plant safety control systemsVerifying Therapy Safety Interlock System with SPIN Motlatsi Seotsanyana1 , Jaco Geldenhuys2 1

  20. UTEP Master of Occupational Therapy Program Application Process and Requirements

    E-Print Network [OSTI]

    Ward, Karen

    /Occupational Therapy Academic Services Building, Rm 223 University of Texas at El Paso 601 West Schuster El Paso, Texas 79968 (915) 747-5491 gradschool@utep.edu #12;Rev. 5/11 The University of Texas at El Paso College

  1. Proceedings of the first international symposium on neutron capture therapy

    SciTech Connect (OSTI)

    Fairchild, R.G.; Brownell, G.L. (eds.)

    1982-01-01T23:59:59.000Z

    This meeting was arranged jointly by MIT and BNL in order to illuminate progress in the synthesis and targeting of boron compounds and to evaluate and document progress in radiobiological and dosimetric aspects of neutron capture therapy. It is hoped that this meeting will facilitate transfer of information between groups working in these fields, and encourage synergistic collaboration.

  2. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer ­ Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  3. Accelerated BS/DPT Program Academic Policy and Procedure Manual 1 DOCTOR OF PHYSICAL THERAPY PROGRAM

    E-Print Network [OSTI]

    Guenther, Frank

    ;_____________________________________________________________________________________ Accelerated BS/DPT Program Academic Policy and Procedure Manual 4 Physical Therapy Program Faculty Lisa Brown_____________________________________________________________________________________ Accelerated BS/DPT Program Academic Policy and Procedure Manual 1 DOCTOR OF PHYSICAL THERAPY PROGRAM Academic

  4. Inverse and transient thermal analysis for rapid hyperthermia therapy planning, delivery and evaluation

    E-Print Network [OSTI]

    He, Jialun, 1966-

    2003-01-01T23:59:59.000Z

    The efficacy of hyperthermia therapy can be enhanced if a thermal management system is available for therapy planning, delivery and evaluation. The integrated thermal management system is not yet available, though some ...

  5. Quantitative analysis of non-viral gene therapy in primary liver culture systems

    E-Print Network [OSTI]

    Tedford, Nathan C

    2007-01-01T23:59:59.000Z

    Gene therapy has the potential to cure thousands of diseases caused by genetic abnormalities, provide novel combination therapies for cancers and viral infections, and offer a new and effective platform for next generation ...

  6. Boron containing compounds and their preparation and use in neutron capture therapy

    DOE Patents [OSTI]

    Gabel, D.

    1992-09-01T23:59:59.000Z

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  7. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOE Patents [OSTI]

    Gabel, D.

    1991-06-04T23:59:59.000Z

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  8. Viewing spin structures with soft x-ray microscopy

    SciTech Connect (OSTI)

    Fischer, Peter

    2010-06-01T23:59:59.000Z

    The spin of the electron and its associated magnetic moment marks the basic unit for magnetic properties of matter. Magnetism, in particular ferromagnetism and antiferromagnetism is described by a collective order of these spins, where the interaction between individual spins reflects a competition between exchange, anisotropy and dipolar energy terms. As a result the energetically favored ground state of a ferromagnetic system is a rather complex spin configuration, the magnetic domain structure. Magnetism is one of the eldest scientific phenomena, yet it is one of the most powerful and versatile utilized physical effects in modern technologies, such as in magnetic storage and sensor devices. To achieve highest storage density, the relevant length scales, such as the bit size in disk drives is now approaching the nanoscale and as such further developments have to deal with nanoscience phenomena. Advanced characterization tools are required to fully understand the underlying physical principles. Magnetic microscopes using polarized soft X-rays offer a close-up view into magnetism with unique features, these include elemental sensitivity due to X-ray magnetic dichroism effects as contrast mechanism, high spatial resolution provided by state-of-the-art X-ray optics and fast time resolution limited by the inherent time structure of current X-ray sources, which will be overcome with the introduction of ultrafast and high brilliant X-ray sources.

  9. Einstein, incompleteness, and the epistemic view of quantum states

    E-Print Network [OSTI]

    Nicholas Harrigan; Robert W. Spekkens

    2007-06-18T23:59:59.000Z

    Does the quantum state represent reality or our knowledge of reality? In making this distinction precise, we are led to a novel classification of hidden variable models of quantum theory. Indeed, representatives of each class can be found among existing constructions for two-dimensional Hilbert spaces. Our approach also provides a fruitful new perspective on arguments for the nonlocality and incompleteness of quantum theory. Specifically, we show that for models wherein the quantum state has the status of something real, the failure of locality can be established through an argument considerably more straightforward than Bell's theorem. The historical significance of this result becomes evident when one recognizes that the same reasoning is present in Einstein's preferred argument for incompleteness, which dates back to 1935. This fact suggests that Einstein was seeking not just any completion of quantum theory, but one wherein quantum states are solely representative of our knowledge. Our hypothesis is supported by an analysis of Einstein's attempts to clarify his views on quantum theory and the circumstance of his otherwise puzzling abandonment of an even simpler argument for incompleteness from 1927.

  10. $?$-Ray Pulsars: Emission Zones and Viewing Geometries, A Computer Animation

    E-Print Network [OSTI]

    I. -A. Yadigaroglu; Roger W. Romani

    1994-06-08T23:59:59.000Z

    The computer animation illustrates the geometries described in a paper by the same authors. The preprint is available as number 9401045. The opening scene shows dipole field lines emanating from the polar caps of a rotating neutron star. The dipole axis is inclined along the green rods. The field lines shown are defined from the condition that they be tangent to the light cylinder (the cylindrical radius at which the tangential velocity of rotation reaches the speed of light). The static dipole field lines are smoothly morphed into the correct retarted-potential vacuum solutions. A red surface spanning these field lines is painted. In the next scene the blue surfaces represent the outer gaps above the surface of last closed field lines. High energy emission (blue) is produced in these outer gaps, and is beamed tangentially along the field lines. The radio emission (green) originates close to the surface of the star and is beamed along the dipole axes. The inclination angle $\\alpha$ of the dipole and the viewing angle $\\zeta$ are chosen to match the Crab parameters; $\\alpha$ = 70, $\\zeta$ = 65. The corresponding light curve is computed and shown for these angles, and the red dot traces rotation phase. The next scene shows the situation for angles appropriate to PSR1706-44; $\\alpha$ = 45, $\\zeta$ = 65. The final scene is a possibility for Geminga; $\\alpha$ = 20, $\\zeta$ = 75. These angles are poorly constrained as there is no radio emission.

  11. Page 1 of 1 BACHELOR OF ORAL HEALTH (Therapy/Hygiene)

    E-Print Network [OSTI]

    Thomas, Richard C.

    Page 1 of 1 BACHELOR OF ORAL HEALTH (Therapy/Hygiene) REQUEST FOR SCHOOL PREDICTED SCORE YEAR 12 The above student wishes to apply for the Bachelor Oral Health (Therapy/Hygiene) at Charles Sturt University assessment for the Bachelor of Oral Health (Therapy/Hygiene) degree and must be received at Charles Sturt

  12. Bachelor of Oral Health (Therapy/Hygiene): Instructions for Applicants Page 1 of 2 INSTRUCTIONS FOR

    E-Print Network [OSTI]

    Thomas, Richard C.

    Bachelor of Oral Health (Therapy/Hygiene): Instructions for Applicants Page 1 of 2 INSTRUCTIONS FOR DOMESTIC APPLICANTS BACHELOR OF ORAL HEALTH (Therapy/Hygiene) CAREFULLY READ THESE INSTRUCTIONS BEFORE COMPLETING THE BACHELOR OF ORAL HEALTH (THERAPY/HYGIENE) SUPPLEMENTARY APPLICATION FORM. IMPORTANT NOTES

  13. ORIGINAL ARTICLE Therapy model for advanced intracerebral B16 mouse melanoma

    E-Print Network [OSTI]

    Terasaki, Mark

    ORIGINAL ARTICLE Therapy model for advanced intracerebral B16 mouse melanoma using radiation for advanced intracerebral B16 melanoma is reported. Implanted tumors (D0), suppressed by a single 15 Gy- bination therapies for brain tumors. Keywords B16 melanoma Á Mouse Á Brain tumor Á Radiation therapy Á

  14. The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by

    E-Print Network [OSTI]

    Enomoto, Ryoji

    The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by the HETE-2 and localize Gamma-ray bursts (GRBs) in wide field of view. HETE-2 have been localized about 20 GRBs per year hours after the burst. 1. The High Energy Transient Explorer 2 Gamma-ray burst (GRB) is the most

  15. Modeling 3D animals from a side-view sketch Even Entema,b

    E-Print Network [OSTI]

    Barthe, Loïc

    Modeling 3D animals from a side-view sketch Even Entema,b , Loic Barthea , Marie-Paule Canib. This paper tackles the problem of creating 3D models of animals from a single, side-view sketch. We use be an important step for generat- ing more lively virtual worlds. Animals are also among the models

  16. Reconstructions in limited-view thermoacoustic tomography Yuan Xu and Lihong V. Wanga)

    E-Print Network [OSTI]

    Ambartsoumian, Gaik

    Reconstructions in limited-view thermoacoustic tomography Yuan Xu and Lihong V. Wanga) Optical for publication 9 December 2003; published 11 March 2004 The limited-view problem is studied for thermoacoustic of Physicists in Medicine. DOI: 10.1118/1.1644531 Key words: thermoacoustic tomography, photoacoustic tomography

  17. Study on neutron radiation field of carbon ions therapy

    E-Print Network [OSTI]

    Xu, Jun-Kui; Li, Wu-Yuan; Yan, Wei-Wei; Chen, Xi-Meng; Mao, Wang; Pang, Cheng-Guo

    2015-01-01T23:59:59.000Z

    Carbon ions offer significant advantages for deep-seated local tumors therapy due to their physical and biological properties. Secondary particles, especially neutrons caused by heavy ion reactions should be carefully considered in treatment process and radiation protection. For radiation protection purposes, the FLUKA Code was used in order to evaluate the radiation field at deep tumor therapy room of HIRFL in this paper. The neutron energy spectra, neutron dose and energy deposition of carbon ion and neutron in tissue-like media was studied for bombardment of solid water target by 430MeV/u C ions. It is found that the calculated neutron dose have a good agreement with the experimental date, and the secondary neutron dose may not exceed one in a thousand of the carbon ions dose at Bragg peak area in tissue-like media.

  18. Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy

    SciTech Connect (OSTI)

    Munaweera, Imalka; Balkus, Kenneth J. Jr., E-mail: Balkus@utdallas.edu, E-mail: Anthony.DiPasqua@unthsc.edu [Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, Texas 75080 (United States); Koneru, Bhuvaneswari; Shi, Yi; Di Pasqua, Anthony J., E-mail: Balkus@utdallas.edu, E-mail: Anthony.DiPasqua@unthsc.edu [Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107 (United States)

    2014-11-01T23:59:59.000Z

    Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, {sup 1}H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.

  19. Protection Strategy of Sensitive Body Organs in Radiation Therapy

    E-Print Network [OSTI]

    Abolfath, Ramin M

    2009-01-01T23:59:59.000Z

    In this paper, we investigate protection strategies of sensitive body anatomy against the irradiation to the cancerous moving tumors in intensity modulated radiation therapy. Inspired by optimization techniques developed in statistical physics and dynamical systems, we deploy a method based on variational principles and formulate an efficient genetic algorithm which enable us to search for global minima in a complex landscape of irradiation dose delivered to the radiosensitive organs at risk. We take advantage of the internal motion of body anatomy during radiation therapy to reduce the unintentional delivery of the radiation to sensitive organs. We show that the accurate optimization of the control parameters, compare to the conventional IMRT and widely used delivery based on static anatomy assumption, leads to a significant reduction of the dose delivered to the organs at risk.

  20. A Novel Linear Accelerator For Image Guided Radiation Therapy

    SciTech Connect (OSTI)

    Ding Xiaodong; Boucher, Salime [RadiaBeam Technologies, 1717 Stewart St., Santa Monica, CA 90404 (United States)

    2011-06-01T23:59:59.000Z

    RadiaBeam is developing a novel linear accelerator which produces both kilovoltage ({approx}100 keV) X-rays for imaging, and megavoltage (6 to 20 MeV) X-rays for therapy. We call this system the DEXITron: Dual Energy X-ray source for Imaging and Therapy. The Dexitron is enabled by an innovation in the electromagnetic design of the linac, which allows the output energy to be rapidly switched from high energy to low energy. In brief, the method involves switching the phase of the radiofrequency (RF) power by 180 degrees at some point in the linac such that, after that point, the linac decelerates the beam, rather than accelerating it. The Dexitron will have comparable cost to other linacs, and avoids the problems associated with current IGRT equipment.

  1. Nanoscience and Nanotechnology: From Energy Applications to Advanced Medical Therapies

    ScienceCinema (OSTI)

    Tijana Rajh

    2010-01-08T23:59:59.000Z

    Dr. Rajh will present a general talk on nanotechnology ? an overview of why nanotechnology is important and how it is useful in various fields. The specific focus will be on Solar energy conversion, environmental applications and advanced medical therapies. She has broad expertise in synthesis and characterization of nanomaterials that are used in nanotechnology including novel hybrid systems connecting semiconductors to biological molecules like DNA and antibodies. This technology could lead to new gene therapy procedures, cancer treatments and other medical applications. She will also discuss technologies made possible by organizing small semiconductor particles called quantum dots, materials that exhibit a rich variety of phenomena that are size and shape dependent. Development of these new materials that harnesses the unique properties of materials at the 1-100 nanometer scale resulted in the new field of nanotechnology that currently affects many applications in technological and medical fields.

  2. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko (Hampton Bays, NY); Slatkin, Daniel N. (Southold, NY)

    1997-03-18T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  3. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko (Hampton Bays, NY); Slatkin, Daniel N. (Southold, NY)

    1995-10-03T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  4. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko (Hampton Bays, NY); Slatkin, Daniel N. (Southold, NY)

    1997-08-05T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  5. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-08-05T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  6. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-03-18T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  7. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1995-10-03T23:59:59.000Z

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  8. DeepView: A collaborative framework for distributed microscopy

    SciTech Connect (OSTI)

    Parvin, B.; Taylor, J.; Cong, G.

    1998-08-10T23:59:59.000Z

    This paper outlines the motivation, requirements, and architecture of a collaborative framework for distributed virtual microscopy. In this context, the requirements are specified in terms of (1) functionality, (2) scalability, (3) interactivity, and (4) safety and security. Functionality refers to what and how an instrument does something. Scalability refers to the number of instruments, vendor-specific desktop workstations, analysis programs, and collaborators that can be accessed. Interactivity refers to how well the system can be steered either for static or dynamic experiments. Safety and security refers to safe operation of an instrument coupled with user authentication, privacy, and integrity of data communication. To meet these requirements, we introduce three types of services in the architecture: Instrument Services (IS), Exchange Services (ES), and Computational Services (CS). These services may reside on any host in the distributed system. The IS provide an abstraction for manipulating different types of microscopes; the ES provide common services that are required between different resources; and the CS provide analytical capabilities for data analysis and simulation. These services are brought together through CORBA and its enabling services, e.g., Event Services, Time Services, Naming Services, and Security Services. Two unique applications have been introduced into the CS for analyzing scientific images either for instrument control or recovery of a model for objects of interest. These include: in-situ electron microscopy and recovery of 3D shape from holographic microscopy. The first application provides a near real-time processing of the video-stream for on-line quantitative analysis and the use of that information for closed-loop servo control. The second application reconstructs a 3D representation of an inclusion (a crystal structure in a matrix) from multiple views through holographic electron microscopy. These application require steering external stimuli or computational parameters for a particular result. In a sense, ''computational instruments'' (symmetric multiprocessors) interact closely with data generated from ''experimental instruments'' (unique microscopes) to conduct new experiments and bring new functionalities to these instruments. Both of these features exploit high-performance computing and low-latency networks to bring novel functionalities to unique scientific imaging instruments.

  9. Incorporating range uncertainty into proton therapy treatment planning

    E-Print Network [OSTI]

    McGowan, Stacey Elizabeth

    2015-06-09T23:59:59.000Z

    Nazionale di Adroterapia Oncologica CNS Central Nervous System CPAC Compact Particle Acceleration Corporation CRUK Cancer Research UK CT Computed Tomography CTV Clinical Target Volume DDA Dose Difference Analysis DECT Dual Energy Computed Tomography DET... of MVCT HU to proton stopping power relative to water . 47 3.7 Image of truncated patient on TomoTherapy showing the the scanning circle (white circle). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 4.1 Heat plots of %volume range...

  10. A Computational and Experimental Approach to Understanding HIV-1 Evolution and Latency for the Design of Improved Antiviral Therapies

    E-Print Network [OSTI]

    Dey, Siddharth Subhas

    2012-01-01T23:59:59.000Z

    Design of Improved Antiviral Therapies by Siddharth Subhas Dey Doctor of Philosophy in Chemical Engineering

  11. Optic for an endoscope/borescope having high resolution and narrow field of view

    DOE Patents [OSTI]

    Stone, Gary F.; Trebes, James E.

    2003-10-28T23:59:59.000Z

    An optic having optimized high spatial resolution, minimal nonlinear magnification distortion while at the same time having a limited chromatic focal shift or chromatic aberrations. The optic located at the distal end of an endoscopic inspection tool permits a high resolution, narrow field of view image for medical diagnostic applications, compared to conventional optics for endoscopic instruments which provide a wide field of view, low resolution image. The image coverage is over a narrow (<20 degrees) field of view with very low optical distortion (<5% pin cushion or barrel distortion. The optic is also optimized for best color correction as well as to aid medical diagnostics.

  12. TomoTherapy MLC verification using exit detector data

    SciTech Connect (OSTI)

    Chen Quan; Westerly, David; Fang Zhenyu; Sheng, Ke; Chen Yu [TomoTherapy Inc., 1240 Deming Way, Madison, Wisconsin 53717 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Xinghua Cancer Hospital, Xinghua, Jiangsu 225700 (China); Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, California 90095 (United States); TomoTherapy Inc., 1240 Deming Way, Madison, Wisconsin 53717 (United States)

    2012-01-15T23:59:59.000Z

    Purpose: Treatment delivery verification (DV) is important in the field of intensity modulated radiation therapy (IMRT). While IMRT and image guided radiation therapy (IGRT), allow us to create more conformal plans and enables the use of tighter margins, an erroneously executed plan can have detrimental effects on the treatment outcome. The purpose of this study is to develop a DV technique to verify TomoTherapy's multileaf collimator (MLC) using the onboard mega-voltage CT detectors. Methods: The proposed DV method uses temporal changes in the MVCT detector signal to predict actual leaf open times delivered on the treatment machine. Penumbra and scattered radiation effects may produce confounding results when determining leaf open times from the raw detector data. To reduce the impact of the effects, an iterative, Richardson-Lucy (R-L) deconvolution algorithm is applied. Optical sensors installed on each MLC leaf are used to verify the accuracy of the DV technique. The robustness of the DV technique is examined by introducing different attenuation materials in the beam. Additionally, the DV technique has been used to investigate several clinical plans which failed to pass delivery quality assurance (DQA) and was successful in identifying MLC timing discrepancies as the root cause. Results: The leaf open time extracted from the exit detector showed good agreement with the optical sensors under a variety of conditions. Detector-measured leaf open times agreed with optical sensor data to within 0.2 ms, and 99% of the results agreed within 8.5 ms. These results changed little when attenuation was added in the beam. For the clinical plans failing DQA, the dose calculated from reconstructed leaf open times played an instrumental role in discovering the root-cause of the problem. Throughout the retrospective study, it is found that the reconstructed dose always agrees with measured doses to within 1%. Conclusions: The exit detectors in the TomoTherapy treatment systems can provide valuable information about MLC behavior during delivery. A technique to estimate the TomoTherapy binary MLC leaf open time from exit detector signals is described. This technique is shown to be both robust and accurate for delivery verification.

  13. Pitfalls of tungsten multileaf collimator in proton beam therapy

    SciTech Connect (OSTI)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202 (United States) and Indiana University Health Proton Therapy Center (Formerly Midwest Proton Radiotherapy Institute), Bloomington, Indiana 47408 (United States)

    2011-12-15T23:59:59.000Z

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase due to {sup 179}Ta with a half-life of 1.82 yr and thus require prolonged storage for activity cooling. The H*(10) near the patient side of the tungsten block is about 100 {mu}Sv/h and is 27 times higher at the upstream side of the block. This would lead to an accumulated dose for therapists in a year that may exceed occupational maximum permissible dose (50 mSv/yr). The value of H*(10) at the upstream surface of the tungsten block is about 220 times higher than that of the brass. Conclusions: MLC is an efficient way for beam shaping and overall cost reduction device in proton therapy. However, based on this study, tungsten seems to be not an optimal material for MLC in proton beam therapy. Usage of tungsten MLC in clinic may create unnecessary risks associated with the secondary neutrons and induced radioactivity for patients and staff depending on the patient load. A careful selection of material for manufacturing of an optimal MLC for proton therapy is thus desired.

  14. Remote Participation at EFDA­JET Task Force Work, Experience and Priorities from a User’s Point of View

    E-Print Network [OSTI]

    Remote Participation at EFDA­JET Task Force Work, Experience and Priorities from a User’s Point of View

  15. Moving Toward a Vision of Family Independence: Local Managers' Views of Michigan's Welfare Reforms

    E-Print Network [OSTI]

    Shyy, Wei

    Reforms Kristin S. Seefeldt Jodi Sandfort Sandra K. Danziger February, 1998 This project is supported? .................................................................................39 SECTION IV: MANAGERS' VIEW OF WELFARE REFORM AND IMPLEMENTATION ISSUES......................................................................44 Support for Reform Initiatives

  16. THESIS FOR THE DEGREE OF LICENTIATE OF ENGINEERING View Frustum Culling and Animated Ray Tracing

    E-Print Network [OSTI]

    Assarsson, Ulf

    THESIS FOR THE DEGREE OF LICENTIATE OF ENGINEERING View Frustum Culling and Animated Ray Tracing Thesis for the degree of Licentiate of Engineering, a Swedish degree between M.Sc. and Ph.D. Abstract

  17. DOE Zero Energy Ready Home Case Study 2014: Clifton View Homes...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    founder of Clifton View Homes and Zero-Energy Plans, LLC, strives to go beyond net zero energy construction so that every home he designs and builds can produce enough...

  18. Direct imaging with highly diluted apertures. I. Field of view limitations

    E-Print Network [OSTI]

    O. Lardiere; F. Martinache; F. Patru

    2006-12-04T23:59:59.000Z

    Future optical interferometric instrumentation mainly relies on the availability of an efficient cophasing system: once available, what has so far postponed the relevance of direct imaging with an interferometer will vanish. This paper focuses on the actual limits of snapshot imaging, inherent to the use of a sparse aperture: the number of telescopes and the geometry of the array impose the maximum extent of the field of view and the complexity of the sources. A second limitation may arise from the beam combination scheme. Comparing already available solutions, we show that the so called hypertelescope mode (or densified pupil) is ideal. By adjusting the direct imaging field of view to the useful field of view offered by the array, the hypertelescope makes an optimal use of the collected photons. It optimizes signal to noise ratio, drastically improves the luminosity of images and makes the interferometer compatible with coronagraphy, without inducing any loss of useful field of view.

  19. California’s Energy Future: The View to 2050 - Summary Report

    E-Print Network [OSTI]

    Yang, Christopher

    2011-01-01T23:59:59.000Z

    carbon capture and storage, especially as a technology thatCarbon capture and sequestration CCST California Council on Science and Technologytechnology California’s Energy Future - The View to 2050 becomes available. ? ? Fossil fuel with carbon capture

  20. Improving Usability of Interactive Graphics Specification and Implementation with Picking Views

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Improving Usability of Interactive Graphics Specification and Implementation with Picking Views.conversy@enac.fr Abstract-- Specifying and programming graphical interactions are difficult tasks, notably because designers architecture improves the usability of the specification and the implementation of graphical interaction

  1. Appendix A Organizational Charts UT System Administration Table of Organization can be viewed at

    E-Print Network [OSTI]

    Cui, Yan

    85 Appendix A ­ Organizational Charts UT System Administration Table of Organization can be viewed can be found at www.uthsc.edu/administration/. An Organizational Chart for UTHSC is shown below. #12

  2. Wind Energy Facilities and Residential Properties: The Effect of Proximity and View on Sales Prices

    E-Print Network [OSTI]

    Hoen, Ben

    2012-01-01T23:59:59.000Z

    impacts of wind energy facilities on the sales prices ofprices were affected by views of and proximity to wind energyprices, and locations in electronic form from local assessors; and (3) the representativeness of the types of wind energy

  3. CONTENT-BASED 3D OBJECT RETRIEVAL USING 2D VIEWS Thibault Napoleon

    E-Print Network [OSTI]

    Sahbi, Hichem

    CONTENT-BASED 3D OBJECT RETRIEVAL USING 2D VIEWS Thibault Napol´eon TELECOM ParisTech, CNRS UMR 5141 46 rue Barrault 75013 Paris, France napoleon@telecom-paristech.fr Hichem Sahbi CNRS UMR 5141

  4. Ecology in Africa: a view from the past for informing the future

    E-Print Network [OSTI]

    Martins, Dino J.

    2013-01-01T23:59:59.000Z

    reviews ISSN 1948?6596  Ecology in Africa: a view from the the future  African Ecology – Benchmarks and Historical s  role  in  shaping  the  ecology  of  Africa…”.   These 

  5. UFilter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani

    E-Print Network [OSTI]

    U­Filter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani 1997 year Simon & Schuster Inc. A02 Prentice­Hall Inc. B01 McGraw­Hill

  6. Automated Deduction: A Technological Point of View Peter Baumgartner, Ingo Dahn, Jrgen Dix, Ulrich Furbach,

    E-Print Network [OSTI]

    Baumgartner, Peter

    1 Automated Deduction: A Technological Point of View Peter Baumgartner, Ingo Dahn, Jürgen Dix called ILF, developed by I. Dahn within the German focus program on Deduction, was able to translate

  7. Cellulosic Biofuels: Expert Views on Prospects for Advancement and Jeffrey Keisler

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Cellulosic Biofuels: Expert Views on Prospects for Advancement Erin Baker and Jeffrey Keisler funding and the likelihood of achieving advances in cellulosic biofuel technologies. While in collecting more information on this technology. Keywords: Biofuels; Technology R&D; Uncertainty

  8. Lifecycle Environments: A Retrospective View of the Contributions of Leon J.

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Lifecycle Environments: A Retrospective View of the Contributions of Leon J. Osterweil Lori A@cs.umass.edu Abstract Throughout his career, Leon Osterweil has made significant contribu- tions that have impacted

  9. U.S. Science Journalists' Views and Uses of Online Reader Comments: A Qualitative Study 

    E-Print Network [OSTI]

    Schaefer, Mary Elizabeth

    2014-09-02T23:59:59.000Z

    publications also provide insight into how some journalists view comments. In an article on the Nieman Reports website, an NPR ombudsman recounts some of her experiences with comments, which have consisted largely of personal attacks, and addresses issues...

  10. Computing point-of-view : modeling and simulating judgments of taste

    E-Print Network [OSTI]

    Liu, Xinyu Hugo, 1979-

    2006-01-01T23:59:59.000Z

    People have rich points-of-view that afford them the ability to judge the aesthetics of people, things, and everyday happenstance; yet viewpoint has an ineffable quality that is hard to articulate in words, let alone capture ...

  11. Negotiating authenticity: a negotiated order study of Valley View Summer Camp

    E-Print Network [OSTI]

    Free, Rebecca J

    1999-01-01T23:59:59.000Z

    the negotiated order of Valley View's summer camp from June 1998 until August 1998. Economic needs, organizational growth, the increasing violent behavior of children, and the mission and history of the camp were aspects of the structural context impacting...

  12. TerraView Plugins HowTo Revision date 12/12/2006

    E-Print Network [OSTI]

    View plugin structure uses a plugin layer library called LibSLP ( see SPL web site5 for reference files (.pro) by using the QT tool called "qmake". Check QT web site for reference. BASE.PRO BASE

  13. GPU-based Scalable Volumetric Reconstruction for Multi-view Stereo

    SciTech Connect (OSTI)

    Kim, H; Duchaineau, M; Max, N

    2011-09-21T23:59:59.000Z

    We present a new scalable volumetric reconstruction algorithm for multi-view stereo using a graphics processing unit (GPU). It is an effectively parallelized GPU algorithm that simultaneously uses a large number of GPU threads, each of which performs voxel carving, in order to integrate depth maps with images from multiple views. Each depth map, triangulated from pair-wise semi-dense correspondences, represents a view-dependent surface of the scene. This algorithm also provides scalability for large-scale scene reconstruction in a high resolution voxel grid by utilizing streaming and parallel computation. The output is a photo-realistic 3D scene model in a volumetric or point-based representation. We demonstrate the effectiveness and the speed of our algorithm with a synthetic scene and real urban/outdoor scenes. Our method can also be integrated with existing multi-view stereo algorithms such as PMVS2 to fill holes or gaps in textureless regions.

  14. Intrinsic modulation of ENSO predictability viewed through a local Lyapunov lens

    E-Print Network [OSTI]

    Wittenberg, Andrew

    Intrinsic modulation of ENSO predictability viewed through a local Lyapunov lens Christina magnitude, frequency, and physical evolution. Local Lyapunov exponents (LLEs) estimated from the monthly Predictability Á Local Lyapunov exponents 1 Introduction The limits of predictability of the state

  15. 176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views

    E-Print Network [OSTI]

    Buratto, Steve

    176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views P humidity. Writing in Nature Nanotechnology, Saeed Moghaddam, Mark Shannon and colleagues1 at the University

  16. Startup of the Kling Center for Proton Therapy

    SciTech Connect (OSTI)

    Bloch, C.; Chen, K. L.; Klein, E. E. [Washington University School of Medicine, 4921 Parkview Place, St. Louis MO 63110 (United States); Hill, P. M. [Univeristy of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 (United States); Saito, A. [Gunma University Heavy Ion Medical Center, 3-39-22 Showa-Machi, Maebashi 371-8511, Gunma (Japan)

    2013-04-19T23:59:59.000Z

    In November of 2011 Mevion Medical Systems (formerly Still River Systems) delivered the Mevion S250 proton therapy system accelerator to the Kling Center for Proton Therapy at the Siteman Cancer Center in Saint Louis. The Mevion system is unique, with an in-room gantry-mounted superconducting synchrocyclotron. This is the first true single-room proton therapy system and it has a greatly reduced size as well as cost. A month after its arrival, the installation was complete and the superconducting magnet was ramped up to full current ({approx}2000 amperes). In March of 2012, full energy beam (250 MeV) was extracted and radiation surveys were performed to verify the shielding. Once that was shown to be sufficient, Mevion began fine-tuning the system to provide a highly isocentric beam from the 50 ton system. In June of 2012 the field-shaping system (energy degraders, contoured scatterers and range modulators) were installed and measurements of the clinical beam properties commenced. Monte Carlo simulations (MCNPX) have been performed for the system and validated with beam measurements done at the factory. These simulations have been used for a preliminary commissioning of our treatment planning system. Additionally, predictions of the neutron background have been made and validated with factory measurements. Final commissioning of the treatment planning system and verification of the neutron background will be accomplished with measurements made later in 2012. Based on current progress, patient treatments are scheduled to begin in late 2012. Beam and radiation background data will be presented.

  17. Prostate treatment with helical TomoTherapy in patients with bilateral hip prostheses—Two case studies

    SciTech Connect (OSTI)

    Kling, Justin, E-mail: justin.kling@globalphysics.net [Midwestern Regional Medical Center, Radiation Oncology, Zion, IL (United States); Patel, Kamal M. [Midwestern Regional Medical Center, Radiation Oncology, Zion, IL (United States)

    2013-04-01T23:59:59.000Z

    Prostate cancer patients with bilateral hip prostheses require additional planning and treatment considerations. Visualization of the organs at risk (OAR) and the planning target volume (PTV) is hindered by the large amount of artifact streaking between the metallic implants. The density of this area must be accounted for when using heterogeneity correction. Fusion of a megavolt computed tomography (MVCT) to the planning CT aids in viewing the prostate, bladder, and rectum, and implantation of 6 fiducial markers along the posterior border of the prostate helps with the delineation between it and the rectum. When planning, the amount of beam entry angles is limited because of the position of the prostheses and prevents the use of any lateral beams. Therefore, TomoTherapy presents an effective option for these patients because of the ability to use a directional block, which prevents any primary beams from entering through the bilateral hip prostheses (but the beams may exit through the structures), use of MVCT for daily localization, and delivery of radiation with intensity modulation allows for effective sparing of the OAR.

  18. Atmospheric pressure cold plasma as an antifungal therapy

    SciTech Connect (OSTI)

    Sun Peng; Wu Haiyan [College of Engineering, Peking University, Beijing 100871 (China); Sun Yi; Liu Wei; Li Ruoyu [Department of Dermatology and Venereology, Peking Univ. 1st Hospital and Research Center for Medical Mycology, Peking Univ., Beijing 100034 (China); Zhu Weidong; Lopez, Jose L. [Department of Applied Science and Technology and Center for Microplasma Science and Technology, Saint Peter's College, Jersey City, New Jersey 07306 (United States); Zhang Jue; Fang Jing [College of Engineering, Peking University, Beijing 100871 (China); Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China)

    2011-01-10T23:59:59.000Z

    A microhollow cathode based, direct-current, atmospheric pressure, He/O{sub 2} (2%) cold plasma microjet was used to inactive antifungal resistants Candida albicans, Candida krusei, and Candida glabrata in air and in water. Effective inactivation (>90%) was achieved in 10 min in air and 1 min in water. Antifungal susceptibility tests showed drastic reduction of the minimum inhibitory concentration after plasma treatment. The inactivation was attributed to the reactive oxygen species generated in plasma or in water. Hydroxyl and singlet molecular oxygen radicals were detected in plasma-water system by electron spin resonance spectroscopy. This approach proposed a promising clinical dermatology therapy.

  19. High contrast, CdTe portal scanner for radiation therapy

    SciTech Connect (OSTI)

    Entine, G.; Squillante, M.R.; Hahn, R.; Cirignano, L.J.; McGann, W. (Radiation Monitoring Devices, Inc., Watertown, MA (United States)); Biggs, P.J. (Massachusetts General Hospital, Boston, MA (United States))

    1992-10-01T23:59:59.000Z

    This paper reports on one of the most promising new technologies for improving the qualify of radiation therapy, the use of real-time systems to produce portal images. In the authors' approach, they are constructing a linear array of 256 CdTe photovoltaic detectors attached to a very compact linear scanner, all of which will be mounted in a cassette shaped package to be located under the patient table. The high stopping power of the CdTe allows a high contrast image to be made using only a single Linac pulse per line, resulting in a high contrast image in under 5 seconds.

  20. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2005-10-04T23:59:59.000Z

    The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

  1. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2003-05-20T23:59:59.000Z

    The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

  2. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

    1999-01-01T23:59:59.000Z

    A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

  3. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, D.W.; Wemple, C.A.

    1999-07-06T23:59:59.000Z

    A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

  4. anti-hiv drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  5. anti-parkinsonian drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  6. E-Print Network 3.0 - autologous cell therapy Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2009 447 The new england Summary: of nonmyeloablative chemo- therapy followed by an infusion of autologous hematopoietic stem cells that had been trans... autologous CD34+ bone...

  7. active anti-retroviral therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    treatments. There are differences between the hospitals how the treatments with radiopharmaceuticals are performed and how the activity for the therapy is determined. Mostly, the...

  8. E-Print Network 3.0 - alternative medical therapies Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for: alternative medical therapies Page: << < 1 2 3 4 5 > >> 1 Louisiana State University Health Care Services Division Medical Center of Louisiana at New Orleans Summary: are...

  9. anticoagulant therapy re-ly: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  10. On bolus for megavoltage photon and electron radiation therapy

    SciTech Connect (OSTI)

    Vyas, Vedang [University of Waterloo, Waterloo, Ontario (Canada); Grand River Regional Cancer Centre, Kitchener, Ontario (Canada); Palmer, Lisa; Mudge, Ray [Grand River Regional Cancer Centre, Kitchener, Ontario (Canada); Jiang, Runqing [University of Waterloo, Waterloo, Ontario (Canada); Grand River Regional Cancer Centre, Kitchener, Ontario (Canada); Fleck, Andre [Grand River Regional Cancer Centre, Kitchener, Ontario (Canada); Schaly, Bryan [London Regional Cancer Program, London, Ontario (Canada); Osei, Ernest [University of Waterloo, Waterloo, Ontario (Canada); Grand River Regional Cancer Centre, Kitchener, Ontario (Canada); Charland, Paule, E-mail: paule.charland@grhosp.on.ca [Grand River Regional Cancer Centre, Kitchener, Ontario (Canada)

    2013-10-01T23:59:59.000Z

    Frequently, in radiation therapy one must treat superficial lesions on cancer patients; these are at or adjacent to the skin. Megavoltage photon radiotherapy penetrates through the skin to irradiate deep-seated tumors, with skin-sparing property. Hence, to treat superficial lesions, one must use a layer of scattering material to feign as the skin surface. Although megavoltage electron beams are used for superficial treatments, one occasionally needs to enhance the dose near the surface. Such is the function of a “bolus,” a natural or synthetically developed material that acts as a layer of tissue to provide a more effective treatment to the superficial lesions. Other uses of boluses are to correct for varying surface contours and to add scattering material around the patient's surface. Materials used as bolus vary from simple water to metal and include various mixtures and compounds. Even with the modernization of the technology for external-beam therapy and the emergence of various commercial boluses, the preparation and utilization of a bolus in clinical radiotherapy remains an art. Considering the varying experiences and practices, this paper briefly summarizes available boluses that have been proposed and are employed in clinical radiotherapy. Although this review is not exhaustive, it provides some initial guidance and answers questions that may arise in clinical practice.

  11. Remote Viewing End Effectors for Light Duty Utility Arm Robot (U)

    SciTech Connect (OSTI)

    Heckendorn, F.M. [Westinghouse Savannah River Company, AIKEN, SC (United States); Robinson, C.W.; Haynes, H.B.; Anderosn, E.K.; Pardini, A.F. [Westinghouse Hanford Co., Richland, WA (United States)

    1996-11-04T23:59:59.000Z

    The Robotics Development Groups at the Savannah River Site (SRS) and at the Hanford site have developed remote video and photography systems for deployment in underground radioactive-waste storage tanks at the Department of Energy (DOE) sites as a part of the Office of Science and Technology (OST) program within DOE. Viewing and documenting the tank interiors and their associated annular spaces is an extremely valuable tool in characterizing their condition and contents and in controlling their remediation. Several specialized video/photography systems and robotic End Effectors have been fabricated that provide remote viewing and lighting. All are remotely deployable into and out of the tank, with all viewing functions remotely operated. Positioning all control components away from the facility prevents the potential for personnel exposure to radiation and contamination. Only the remote video systems are discussed in this paper.

  12. The host immunological response to cancer therapy: An emerging concept in tumor biology

    SciTech Connect (OSTI)

    Voloshin, Tali [Department of Molecular Pharmacology, Rappaport Faculty of Medicine and the Rappaport Institute, Technion—Israel Institute of Technology, 1 Efron Street, Bat Galim, Haifa 31096 (Israel); Voest, Emile E. [Department of Medical Oncology, University Medical Center Utrecht, Utrecht (Netherlands); Shaked, Yuval, E-mail: yshaked@tx.technion.ac.il [Department of Molecular Pharmacology, Rappaport Faculty of Medicine and the Rappaport Institute, Technion—Israel Institute of Technology, 1 Efron Street, Bat Galim, Haifa 31096 (Israel)

    2013-07-01T23:59:59.000Z

    Almost any type of anti-cancer treatment including chemotherapy, radiation, surgery and targeted drugs can induce host molecular and cellular immunological effects which, in turn, can lead to tumor outgrowth and relapse despite an initial successful therapy outcome. Tumor relapse due to host immunological effects is attributed to angiogenesis, tumor cell dissemination from the primary tumors and seeding at metastatic sites. This short review will describe the types of host cells that participate in this process, the types of factors secreted from the host following therapy that can promote tumor re-growth, and the possible implications of this unique and yet only partially-known process. It is postulated that blocking these specific immunological effects in the reactive host in response to cancer therapy may aid in identifying new host-dependent targets for cancer, which in combination with conventional treatments can prolong therapy efficacy and extend survival. Additional studies investigating this specific research direction—both in preclinical models and in the clinical setting are essential in order to advance our understanding of how tumors relapse and evade therapy. -- Highlights: • Cancer therapy induces host molecular and cellular pro-tumorigenic effects. • Host effects in response to therapy may promote tumor relapse and metastasis. • The reactive host consists of immunological mediators promoting tumor re-growth. • Blocking therapy-induced host mediators may improve outcome.

  13. Cyclotron Produced Radionuclides for Diagnosis and Therapy of Human Neoplasms

    SciTech Connect (OSTI)

    Steven Larson MD

    2009-09-21T23:59:59.000Z

    This project funded since 1986 serves as a core project for cancer research throughout MSKCC, producing key radiotracers as well as basic knowledge about thel physics of radiation decay and imaging, for nuclear medicine applications to cancer diagnosis and therapy. In recent years this research application has broadened to include experiments intended to lead to an improved understanding of cancer biology and into the discovery and testing of new cancer drugs. Advances in immune based radiotargeting form the basis for this project. Both antibody and cellular based immune targeting methods have been explored. The multi-step targeting methodologies (MST) developed by NeoRex (Seattle,Washington), have been adapted for use with positron emitting isotopes and PET allowing the quantification and optimization of targeted delivery. In addition, novel methods for radiolabeling immune T-cells with PET tracers have advanced our ability to track these cells of prolonged period of time.

  14. Visceral Blood Flow Modulation: Potential Therapy for Morbid Obesity

    SciTech Connect (OSTI)

    Harris, Tyler J., E-mail: tjharris@gmail.com [University of California, Los Angeles, Department of Vascular and Interventional Radiology (United States); Murphy, Timothy P.; Jay, Bryan S. [Rhode Island Hospital, Brown University, Department of Diagnostic Imaging, Vascular Disease Research Center (United States); Hampson, Christopher O.; Zafar, Abdul M. [University of Texas Health Science Center at San Antonio, Department of Radiology (United States)

    2013-06-15T23:59:59.000Z

    We present this preliminary investigation into the safety and feasibility of endovascular therapy for morbid obesity in a swine model. A flow-limiting, balloon-expandable covered stent was placed in the superior mesenteric artery of three Yorkshire swine after femoral arterial cutdown. The pigs were monitored for between 15 and 51 days after the procedure and then killed, with weights obtained at 2-week increments. In the two pigs in which the stent was flow limiting, a reduced rate of weight gain (0.42 and 0.53 kg/day) was observed relative to the third pig (0.69 kg/day), associated with temporary food aversion and signs of mesenteric ischemia in one pig.

  15. "A force illegible": A study of Emily Dickinson's view of God

    E-Print Network [OSTI]

    Thompson, Margaret Henderson

    1970-01-01T23:59:59.000Z

    "A FORCE ILLEGIBLE": A STUDY OF EMILY DICKINSON'S VIEW OF GOD A Thesis by MARGARET HENDERSON THOMPSON Submitted to the Graduate College of Texas AErM University in partial fulfillment of the requirement for the degree of MASTER OF ARTS... December 1970 Major Subject: English "A FORCE ILLEGIBI v": A STUDY OF EMILY DICKINSON'S VIEW OF GOD A Thesis by MARGARET HENDERSON THOMPSON Approved as to style and content by: ~Ai'-&~ ei . ~ --~, (y~. g" ~z-7& j a1rman 0 omml. ttee Hea o...

  16. Television Viewing, Walking Speed and Grip Strength in a Prospective Cohort Study

    E-Print Network [OSTI]

    Keevil, Victoria L.; Wijndaele, Katrien; Luben, Robert; Sayer, Avan A.; Wareham, Nicholas J.; Khaw, Kay-Tee

    2014-07-18T23:59:59.000Z

    , strong and consistent associations between grip strength and TV viewing time were not observed. Isometric muscle strength encapsulates only one aspect of muscle func- tion, and low performance may be present without low strength or vice versa, a concept... for age, physical activity, anthropome- try, wealth, comorbidity, smoking, and alcohol intake and combined if no sex–TV viewing time interactions were identified. Results: Men and women who watched the least TV at the 2HC or 3HC walked at a faster usual...

  17. Hypofractionated Radiation Therapy for Breast Ductal Carcinoma In Situ

    SciTech Connect (OSTI)

    Hathout, Lara [Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, Centre affilié à l'Université de Montréal, Montreal, Quebec (Canada); Hijal, Tarek [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Théberge, Valérie [Department of Radiation Oncology, Centre hospitalier universitaire de Québec, L'Hôtel-Dieu de Québec, Quebec (Canada); Centre des maladies du sein Deschênes-Fabia, Quebec (Canada); Fortin, Bernard [Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, Centre affilié à l'Université de Montréal, Montreal, Quebec (Canada); Vulpe, Horia [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Hogue, Jean-Charles [Centre des maladies du sein Deschênes-Fabia, Quebec (Canada); Centre hospitalier universitaire de Québec, Hôpital St-Sacrement, Quebec (Canada); Lambert, Christine [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Bahig, Houda [Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, Centre affilié à l'Université de Montréal, Montreal, Quebec (Canada); and others

    2013-12-01T23:59:59.000Z

    Purpose: Conventional radiation therapy (RT) administered in 25 fractions after breast-conserving surgery (BCS) is the standard treatment for ductal carcinoma in situ (DCIS) of the breast. Although accelerated hypofractionated regimens in 16 fractions have been shown to be equivalent to conventional RT for invasive breast cancer, few studies have reported results of using hypofractionated RT in DCIS. Methods and Materials: In this multicenter collaborative effort, we retrospectively reviewed the records of all women with DCIS at 3 institutions treated with BCS followed by hypofractionated whole-breast RT (WBRT) delivered in 16 fractions. Results: Between 2003 and 2010, 440 patients with DCIS underwent BCS followed by hypofractionated WBRT in 16 fractions for a total dose of 42.5 Gy (2.66 Gy per fraction). Boost RT to the surgical bed was given to 125 patients (28%) at a median dose of 10 Gy in 4 fractions (2.5 Gy per fraction). After a median follow-up time of 4.4 years, 14 patients had an ipsilateral local relapse, resulting in a local recurrence-free survival of 97% at 5 years. Positive surgical margins, high nuclear grade, age less than 50 years, and a premenopausal status were all statistically associated with an increased occurrence of local recurrence. Tumor hormone receptor status, use of adjuvant hormonal therapy, and administration of additional boost RT did not have an impact on local control in our cohort. On multivariate analysis, positive margins, premenopausal status, and nuclear grade 3 tumors had a statistically significant worse local control rate. Conclusions: Hypofractionated RT using 42.5 Gy in 16 fractions provides excellent local control for patients with DCIS undergoing BCS.

  18. Feasibility of a predictive model of Hsp70b-activated gene therapy protein expression during ultrasound hyperthermia

    E-Print Network [OSTI]

    Silcox, Christina Elise

    2014-01-01T23:59:59.000Z

    Gene therapy has been heralded as a possible approach to a variety of diseases and conditions, ranging from cancer and heart disease to blindness and neurodegenerative diseases. However, progress in gene therapy requires ...

  19. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    therapy is frequently employed to treat or prevent vascularare separate units which both treat this patient population,

  20. Nomograms Predicting Response to Therapy and Outcomes After Bladder-Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer

    SciTech Connect (OSTI)

    Coen, John J., E-mail: jcoen@harthosp.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Paly, Jonathan J.; Niemierko, Andrzej [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Kaufman, Donald S. [Department of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)] [Department of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Heney, Niall M. [Department of Urology, Massachusetts General Hospital, Boston, Massachusetts (United States)] [Department of Urology, Massachusetts General Hospital, Boston, Massachusetts (United States); Spiegel, Daphne Y.; Efstathiou, Jason A.; Zietman, Anthony L.; Shipley, William U. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2013-06-01T23:59:59.000Z

    Purpose: Selective bladder preservation by use of trimodality therapy is an established management strategy for muscle-invasive bladder cancer. Individual disease features have been associated with response to therapy, likelihood of bladder preservation, and disease-free survival. We developed prognostic nomograms to predict the complete response rate, disease-specific survival, and likelihood of remaining free of recurrent bladder cancer or cystectomy. Methods and Materials: From 1986 to 2009, 325 patients were managed with selective bladder preservation at Massachusetts General Hospital (MGH) and had complete data adequate for nomogram development. Treatment consisted of a transurethral resection of bladder tumor followed by split-course chemoradiation. Patients with a complete response at midtreatment cystoscopic assessment completed radiation, whereas those with a lesser response underwent a prompt cystectomy. Prognostic nomograms were constructed predicting complete response (CR), disease-specific survival (DSS), and bladder-intact disease-free survival (BI-DFS). BI-DFS was defined as the absence of local invasive or regional recurrence, distant metastasis, bladder cancer-related death, or radical cystectomy. Results: The final nomograms included information on clinical T stage, presence of hydronephrosis, whether a visibly complete transurethral resection of bladder tumor was performed, age, sex, and tumor grade. The predictive accuracy of these nomograms was assessed. For complete response, the area under the receiving operating characteristic curve was 0.69. The Harrell concordance index was 0.61 for both DSS and BI-DFS. Conclusions: Our nomograms allow individualized estimates of complete response, DSS, and BI-DFS. They may assist patients and clinicians making important treatment decisions.

  1. Working Towards Reform in Mathematics Education: Parents', Teachers', and Students' Views of "Different"1

    E-Print Network [OSTI]

    Civil, Marta

    Working Towards Reform in Mathematics Education: Parents', Teachers', and Students' Views presented at the ACCLAIM Research Symposium 3, Mathematics Education: Reform and Resistance;2 This essay is a reflection on several aspects related to my encounters with the concept of reform

  2. The Universe Viewed in Gamma-Rays 1 Concept of new gamma ray detector

    E-Print Network [OSTI]

    Enomoto, Ryoji

    a sensitivity of a detector at TeV gamma ray range. This method was used for a non-imaging detector as XrayThe Universe Viewed in Gamma-Rays 1 Concept of new gamma ray detector Satoko Osone Institute Abstract We present a concept of a new gamma ray detector in order to observe undetected TeV gamma ray

  3. 44 (2007-5) Fig.1 Exploded view of a radial-flow-type combustor.

    E-Print Network [OSTI]

    Kasagi, Nobuhide

    44 (2007-5) Fig.1 Exploded view of a radial-flow-type combustor. On Catalyst Deployment for Uniform Temperature Distribution in Micro Ceramic Combustor * Takashi OKAMASA, Yuji SUZUKI and Nobuhide KASAGI catalytic combustor using high-precision ceramic tape-casting technology for micro thermophotovoltaic system

  4. New Dimensions of Visual Landscape Assessment Wildlands Management for Wildlife Viewing1

    E-Print Network [OSTI]

    Standiford, Richard B.

    preservation and other activities associated with traditional game management. Fortunately, much of the knowledge and techniques developed for game #12;management can be transferred to considerations of wildlifeNew Dimensions of Visual Landscape Assessment Wildlands Management for Wildlife Viewing1 Tamsie

  5. Message-embedding from a control-theoretical point of view

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Message-embedding from a control-theoretical point of view Gilles Mill´erioux1 , Jos´e Mar´ia Amig emphasis on one of the most attractive schemes, namely, message-embedding. The main conclusion can be stated as fol- lows: a message-embedded cryptosystem is equivalent to a conventional self

  6. Acid rain-the GEGB view G. D. HowellsandA. S. Kallend

    E-Print Network [OSTI]

    Short, Daniel

    Acid rain-the GEGB view G. D. HowellsandA. S. Kallend The article by John Franks (CJ'ern. -B conceh wirh acid rain follows thal policy In 1972.when Swedenput hs Case study on acid tain ro rhe United.Leatherhead,Sury Kr22 7SE. to acid rain,which does not justify th6 conlidenceshown by Franks. 'Acid in

  7. Multi-view Rendering using GPU for 3-D Displays Francois de Sorbier

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Multi-view Rendering using GPU for 3-D Displays Franc¸ois de Sorbier Graduate School of Science content for stereoscopic and auto-stereoscopic displays requires to render a scene several times from slightly different viewpoints. In that case, maintaining real-time rendering can be a difficult goal

  8. Nuclear Waste Disposal: An Independent View of the Big Picture and a Proposal for CARD

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    1 Nuclear Waste Disposal: An Independent View of the Big Picture and a Proposal for CARD Presented to isolate nuclear waste successfully from the biosphere for the long term can be developed if our society to this impasse? In the 1940's at the beginning of the nuclear age, nuclear waste was seen as a "problem" only

  9. NEWS & VIEWS nature physics | VOL 3 | MARCH 2007 | www.nature.com/naturephysics 145

    E-Print Network [OSTI]

    Eggers, Jens

    by wetting -- the tendency of the liquid to spread on a material. Specifically, the critical speed that the flow, as viewed macroscopically, consists of a film of liquid racing along the upper surface of the sphere to close the void, and thus to produce a `plop'. Indeed, significant sound production depends

  10. Critical issues and current views on teaching basic circuits and systems in electrical engineering education

    E-Print Network [OSTI]

    education Joos Vandewalle Department of Electrical Engineering (ESAT) Katholieke Universiteit Leuven B-3001, its impact in the electrical engineering education and in order to increase the intrinsic interestCritical issues and current views on teaching basic circuits and systems in electrical engineering

  11. Reduced form electricity spot price modeling with a view towards spike risk

    E-Print Network [OSTI]

    Gerkmann, Ralf

    Reduced form electricity spot price modeling with a view towards spike risk Prof. Dr. Meyer. Februar 2010, 16:15 Uhr Seminarraum, Ludwigstraße 33 I The recent deregulation of electricity markets has led to the creation of energy exchanges, where the electricity is freely traded. We study the most

  12. Cauchy transforms of measures viewed as some functionals of Fourier transforms #

    E-Print Network [OSTI]

    Jurek, Zbigniew J.

    Cauchy transforms of measures viewed as some functionals of Fourier transforms # Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor­ tant role in complex analysis and more recently in so­called free probability. We show here that the Cauchy transform restricted

  13. Cauchy transforms of measures viewed as some functionals of Fourier transforms

    E-Print Network [OSTI]

    Jurek, Zbigniew J.

    Cauchy transforms of measures viewed as some functionals of Fourier transforms Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor- tant role in complex analysis and more recently in so-called free probability. We show here that the Cauchy transform restricted

  14. P2P Views Over Annotated Documents Konstantinos Karanasos, Ioana Manolescu

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . Publication of such resources is inherently distributed. One could consider up- loading all published content] and social networks' tagging are among the most common methods to express annotations. Here, we designate and annotations. At the core of content sharing in AnnoVIP stand materialized views over the whole network content

  15. The Potential for Scholarly Online Books: Views from the Columbia University

    E-Print Network [OSTI]

    The Potential for Scholarly Online Books: Views from the Columbia University Online Books Evaluation Project* Mary Summerfield, Carol Mandel, and Paul Kantor The Columbia University Online Books Project, Columbia University: Final Report and many other reports and papers, including the re- search

  16. Replacement policies for shared caches on symmetric multicores : a programmer-centric point of view

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Replacement policies for shared caches on symmetric multicores : a programmer-centric point of view-cache replacement policy can be modified for self- performance to be meaningful. Categories and Subject Descriptors multicore processor, quality of service, self-per- formance, shared cache, replacement policy, memory band

  17. Distributed Energy Resources and Control: A power system point of view

    E-Print Network [OSTI]

    Distributed Energy Resources and Control: A power system point of view Oliver Gehrke, Stephanie. This paper gives an overview of the changes that the power system is undergoing and how these affect started in the early 1970s [1], many new tasks have been added to the workload of the power system

  18. PS3060: Perception and Action (L.2) A view from the cockpit of a fly

    E-Print Network [OSTI]

    Zanker, Johannes M.

    PS3060: Perception and Action (L.2) A view from the cockpit of a fly ­ the ecology of navigation · landmark navigation ... a universal problem ... !! perception and action !! the ecological approach perception : · perception happens in an ecological context: surfaces offer much more information than

  19. CSVT 05-03-17 1 4D Wavelet-Based Multi-view Video Coding

    E-Print Network [OSTI]

    Cai, Jianfei

    ) unify the view and temporal decompositions as a generic lifting transform. Secondly, an adaptive coding, high dimensional wavelet, lifting, global and local motion alignment. I. INTRODUCTION wide-viewpoint television, 3D television, immersive teleconference, surveillance, etc, are emerging. The existing

  20. Promoting the Benefits of Geospatial Data and Applications NebraskaView

    E-Print Network [OSTI]

    Nebraska-Lincoln, University of

    Promoting the Benefits of Geospatial Data and Applications NebraskaView Center for Advanced Land-Lincoln Geospatial Information for Nebraska Since the early 1970's, billions of dollars have been spent by the federal government and private sector on satellite-based earth observing systems. Hundreds of geospatial

  1. 3D Reconstruction of the Femoral Bone using two X-ray Images from Orthogonal Views

    E-Print Network [OSTI]

    3D Reconstruction of the Femoral Bone using two X-ray Images from Orthogonal Views B. Nikkhahe of the femur and 97 % of the model femur shaft less than 2 mm from the CT scan. Also the femoral head visualization of the femur including the femoral collumn and condyles is important for the clinician in a number

  2. Transmission System Expansion Plans in View Point of Deterministic, Probabilistic and Security Reliability Criteria

    E-Print Network [OSTI]

    Transmission System Expansion Plans in View Point of Deterministic, Probabilistic and Security control system as well as reasonable strength of grid originally. Because investment for power system the stability, and dynamic characteristics of the new system. A main reason of the separated work process

  3. Multiple Exciton Coherence Sizes in Photosynthetic Antenna Complexes viewed by Pump-Probe Spectroscopy

    E-Print Network [OSTI]

    Mukamel, Shaul

    Multiple Exciton Coherence Sizes in Photosynthetic Antenna Complexes viewed by Pump, 1996X The pump-probe signal from the light-harvesting antenna LH2 of purple bacteria is analyzed using absorption,4,5 pump-probe,11-16 and three pulse echoes.8,17 These measurements show ultrafast energy transfer

  4. Estimating amenity values of street trees and woodland views: a methodological review

    E-Print Network [OSTI]

    of spatial valuation methods. The review revealed a paucity of nationwide or large-scale valuations of street, and on trade-offs and synergies in ecosystem service provision. Objectives This research aimed to: m review methods and approaches to valuing amenity street trees and woodland views ­ and greenspace generally

  5. You are here: Home / News / 3D view of 1D nanostructures More services

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    properties The nanowire battery Hybrid energy storage device is as small as it can possibly get ResearchersYou are here: Home / News / 3D view of 1D nanostructures Share More services Related LinksD nanostructures 09 January 2012 Nanowires show strong piezoelectricity Just 100 nanometers

  6. Optic for industrial endoscope/borescope with narrow field of view and low distortion

    DOE Patents [OSTI]

    Stone, Gary F.; Trebes, James E.

    2005-08-16T23:59:59.000Z

    An optic for the imaging optics on the distal end of a flexible fiberoptic endoscope or rigid borescope inspection tool. The image coverage is over a narrow (<20 degrees) field of view with very low optical distortion (<5% pin cushion or barrel distortion), compared to the typical <20% distortion. The optic will permit non-contact surface roughness measurements using optical techniques. This optic will permit simultaneous collection of selected image plane data, which data can then be subsequently optically processed. The image analysis will yield non-contact surface topology data for inspection where access to the surface does not permit a mechanical styles profilometer verification of surface topology. The optic allows a very broad spectral band or range of optical inspection. It is capable of spectroscopic imaging and fluorescence induced imaging when a scanning illumination source is used. The total viewing angle for this optic is 10 degrees for the full field of view of 10 degrees, compared to 40-70 degrees full angle field of view of the conventional gradient index or GRIN's lens systems.

  7. What if Extinction is Not Forever? A Molecular Paleontologist's View of De-extinction

    E-Print Network [OSTI]

    Archibald, S. Bruce

    want extinct animals to be brought back? Where would a de-extinct species end up living? How would its in response to major climate changes in the past, and why some species go extinct while others persistWhat if Extinction is Not Forever? A Molecular Paleontologist's View of De-extinction Presented

  8. Multiple Coordinated Views for Network Attack Graphs Steven Noel Michael Jacobs Pramod Kalapa Sushil Jajodia

    E-Print Network [OSTI]

    Noel, Steven

    Multiple Coordinated Views for Network Attack Graphs Steven Noel Michael Jacobs Pramod Kalapa graph-based representations have been developed for modeling combinations of low-level network attacks, relatively little attention has been paid to effective techniques for visualizing such attack graphs

  9. Articulated Mesh Animation from Multi-view Silhouettes Daniel Vlasic Ilya Baran Wojciech Matusik

    E-Print Network [OSTI]

    Popovic, Jovan

    , and deformation model learning. CR Categories: I.3.7 [Computer Graphics]: Three Dimensional Graphics and Realism--AnimationArticulated Mesh Animation from Multi-view Silhouettes Daniel Vlasic Ilya Baran Wojciech Matusik Institute of Technology Abstract Details in mesh animations are difficult to generate but they have great

  10. INFORMATION TECHNOLOGY INNOVATION: A VIEW OF LARGE CONTRACTORS1 T. Michael Toole, Member, ASCE

    E-Print Network [OSTI]

    Toole, T. Michael

    page 1 INFORMATION TECHNOLOGY INNOVATION: A VIEW OF LARGE CONTRACTORS1 T. Michael Toole, Member of technological innovations is whether diffusion is driven more by technology-push than by demand-pull mechanisms is to broaden the perspective on information technology (IT) innovation presented here at the congress

  11. NATURE CHEMISTRY | VOL 3 | NOVEMBER 2011 | www.nature.com/naturechemistry 839 news & views

    E-Print Network [OSTI]

    Chen, Peng

    NATURE CHEMISTRY | VOL 3 | NOVEMBER 2011 | www.nature.com/naturechemistry 839 news & views such as gasoline. The efficiency of FCC depends largely on catalysts. To improve the performance of these catalysts are inadequate for probing their catalytic performance. Now, writing in Nature Chemistry, Weckhuysen and co

  12. WindSat Polarimetric View of Greenland Peter Gaiser and 1

    E-Print Network [OSTI]

    Long, David G.

    WindSat Polarimetric View of Greenland 1 Li Li, 1 Peter Gaiser and 1 Elizabeth Twarog 1 Remote and observation geometry signatures, particularly over Greenland and Antarctic where the signatures are related-polarimetric microwavr radiometry; WindSat; snow; Greenland I. INTRODUCTION WindSat, launched in January 2003

  13. SeaWinds views Greenland Ivan S. Ashcraft and David G. Long

    E-Print Network [OSTI]

    Long, David G.

    SeaWinds views Greenland Ivan S. Ashcraft and David G. Long Brigham Young University, MERS facies in Greenland. The duration of the summer melt over the Greenland ice sheet is calculated using backscatter images of Greenland are produced to investigate diurnal varia- tions in backscatter measurements

  14. News and Views Conference Report: Paleoanthropology of the Mani Peninsula (Greece)

    E-Print Network [OSTI]

    Delson, Eric

    News and Views Conference Report: Paleoanthropology of the Mani Peninsula (Greece) K. Harvati & E in Athens and Areopolis, Greece, on the Paleoanthropol- ogy of the Mani Peninsula. The conference publication outside Greece is a short article on forensic implications of damage to one cranium (Coutselinis

  15. A multi-display viewing station that increases productivity and saves space

    E-Print Network [OSTI]

    Saskatchewan, University of

    A multi-display viewing station that increases productivity and saves space Conserve desk space) per monitor · Low-profile base saves desk space · Durable aluminum and steel construction creates that are VESA® MIS-D, 100/75, C compliant · Five-year warranty Product Sheet Space-saving desk stands Ergotron

  16. God and the Human Experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the Human Experience A physicist's case for a theistic world view Julio Gea-Banacloche 1, starting from the basic facts about the human experience of existence. For convenience (but also, when they, in turn, experience the need to look beyond the simple conception of God that saw them

  17. God and the human experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the human experience A physicist's case for a theistic world view Julio Gea-Banacloche 1 and--possibly--relate to that reality, by considering the various aspects of our (human beings') experience of existence. For convenience (but also with an ulterior theological purpose in mind

  18. Pathways for protein folding: is a "new view" needed? Vijay S Pande1

    E-Print Network [OSTI]

    Croquette, Vincent

    Pathways for protein folding: is a "new view" needed? Vijay S Pande1 , Alexander Yu Grosberg2 energy MG Molten globule Introduction How do proteins fold? While the thirty five years since Anfinsen has demonstrated the complexity of protein folding, the search continues for the general principles

  19. NATURE CHEMISTRY | VOL 3 | SEPTEMBER 2011 | www.nature.com/naturechemistry 659 news & views

    E-Print Network [OSTI]

    Sia, Samuel K.

    ion (uranium). The use of chemistry for improving sensors is particularly inspired. Current workNATURE CHEMISTRY | VOL 3 | SEPTEMBER 2011 | www.nature.com/naturechemistry 659 news & views D if analogous enzymes are available for the analyte of interest. Writing in Nature Chemistry, Yi Lu and Yu Xiang

  20. ---Search Finance Home Yahoo! Help Welcome, dalemeade08540 [ ]Sign Out -My Yahoo! View Customize

    E-Print Network [OSTI]

    - - -Search Finance Home Yahoo! Help Welcome, dalemeade08540 [ ]Sign Out -My Yahoo! View Customize Financial News Enter symbol(s) Basic Get Symbol Lookup Associated Press EU Expected to Offer Japan Bigger, Russia, South Korea and China plan to join forces to research uses of fusion energy to create clean, long-term

  1. VIEW OFPASSAIC FALLS by W. H. Bartlett, 1840 FOSSIL GREAT LAKES

    E-Print Network [OSTI]

    Olsen, Paul E.

    to Field Trips,52nd Ann. Mtg.New York State Geology Association, Newark College of Arts and SciencesVIEW OFPASSAIC FALLS by W. H. Bartlett, 1840 FOSSIL GREAT LAKES OF THE NEWARK SUPERGROUP IN NEW JERSEY Paul E. Olsen From: W. Manspeizer (ed.),1980,Field Studies in New Jersey Geology and Guide

  2. Automated RF Testing of the KU Agile Radio 2.0 Using LabView

    E-Print Network [OSTI]

    Kansas, University of

    the command line in LabVIEW, writing it to an external command file, and then calling an external ssh client for the transmitter is set by issuing commands to an MC68HC08 microcontroller which in turn sets the control voltage in Figure 1, the micro controller inputs can be seen as blue lines entering the top of the diagram. The 6

  3. Theory of Evolutionary Algorithms: A Birds Eye View A. E. Eibena

    E-Print Network [OSTI]

    Rudolph, Günter

    Theory of Evolutionary Algorithms: A Birds Eye View A. E. Eibena and G. Rudolphb a Leiden Institute the readers' orientation in evolu- tionary computation theory. In the meanwhile, this survey provides key as a survival task: possible solutions compete with each other for survival (and the right to reproduce

  4. A CSP View on UMLRT structure diagrams Clemens Fischer, ErnstRudiger Olderog and Heike Wehrheim

    E-Print Network [OSTI]

    Habel, Annegret

    A CSP View on UML­RT structure diagrams Clemens Fischer, Ernst­R¨udiger Olderog and Heike Wehrheim UML­RT structure diagrams together with the formal method CSP­OZ combining CSP and Object­Z. While CSP­OZ is used for specifying the system components themselves (by CSP­OZ classes), UML­RT diagrams provide

  5. Transform-Space View: Performing Spatial Join in the Transform Space

    E-Print Network [OSTI]

    Whang, Kyu-Young

    Transform-Space View: Performing Spatial Join in the Transform Space Using Original-Space Indexes that satisfy a given spatial relationship. In spatial joins using indexes, original-space indexes such as the R-tree are widely used. An original-space index is the one that indexes objects as represented in the original space

  6. Faculty of Engineering Courses click on a course to view details

    E-Print Network [OSTI]

    Mottram, Nigel

    ENGINEERING MSc/PgDip 37 MARINE TECHNOLOGY MSc/PgDip/PgCert 04 MECHANICAL ENGINEERING, ADVANCED MSc/PgDip 39 URBAN DESIGN MSc/PgDip/PgCert 08 WIND ENERGY SYSTEMS MSc 33 #12;FACULTY OF ENGINEERING 2 back1 Faculty of Engineering Courses click on a course to view details FACULTY OF ENGINEERING COURSE

  7. Toward Structural Dynamics: Protein Motions Viewed by Chemical Shift Modulations and Direct Detection of CN

    E-Print Network [OSTI]

    Toward Structural Dynamics: Protein Motions Viewed by Chemical Shift Modulations and Direct of anti-correlated fluctuations) in R-helices. This extends the prospects of structure- dynamics, several groups have proposed to investigate the existence of structure-dynamics relationships. We like

  8. Protein structure similarity based on multi-view images generated from 3D molecular visualization

    E-Print Network [OSTI]

    Fukui, Kazuhiro

    to protein structure comparison using canonical angles between two subspaces generated from multiple views extension alignment and the Gauss integral tuning. 1. Introduction In structural biology, finding representation of 3D protein structure as a 31- dimensional feature vector called Gauss Integral Tuning (GIT) [6

  9. Catching the Best Views of Skyline: A Semantic Approach Based on Decisive Subspaces

    E-Print Network [OSTI]

    Pei, Jian

    Catching the Best Views of Skyline: A Semantic Approach Based on Decisive Subspaces Jian Pei1 Wen of skylines remains open: Why and in which subspaces is (or is not) an ob- ject in the skyline? Practically-up and drill- down analysis is introduced. We also develop an efficient algorithm, Skyey, to compute

  10. Shaky emerging economies in view of the global financial crisis: The Turkish economy after three decades of liberal reforms

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    into the heart of the 2007/08 crisis yet, their structural vulnerabilities continue to haunt the futureShaky emerging economies in view of the global financial crisis: The Turkish economy after three2012 #12;1 Shaky emerging economies in view of the global financial crisis: The Turkish economy after

  11. Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of

    E-Print Network [OSTI]

    Radeloff, Volker C.

    Global trade in dairy products involves complex and con- tentious issues. Viewed broadly from the perspective of "society," there are large benefits from liberalizing trade. Viewed narrowly from the perspective of dairy producers, liberalized trade is desirable only if it expands exports and reduces imports

  12. Integrating Web information with XML Concrete Views Tuyt-Trm Dang-Ngoc Huaizhong Kou Georges Gardarin

    E-Print Network [OSTI]

    Boyer, Edmond

    Integrating Web information with XML Concrete Views Tuyêt-Trâm Dang-Ngoc Huaizhong Kou Georges.Lastname}@prism.uvsq.fr ABSTRACT To cope with the difficulties of Web information search, lots of technologies related to Web another Web search engines with general purpose, this paper couples text mining and XML view caching

  13. The thick black line: An analysis of police officer views on racial profiling and the police-minority relationship

    E-Print Network [OSTI]

    Glover, Karen Suzanne

    2004-09-30T23:59:59.000Z

    Much research has been conducted on the police-minority relationship, primarily from the view of the civilian. As central actors, the police view is noticeably absent from the research. I employed in-depth interviews and open-ended survey...

  14. Remote Use of the SOAR 4.25m Telescope with LabVIEW Gerald Cecil*a

    E-Print Network [OSTI]

    Cecil, Gerald

    Remote Use of the SOAR 4.25m Telescope with LabVIEW Gerald Cecil*a , Adam Crain**a , Gérman at all U.S. research universities will be able to use it remotely, avoiding 24+ hrs of travel developed LabVIEW modules for remote observing that minimize bandwidth to the shared LAN atop Cerro Pachón

  15. How to View Clips in the Video Clip Library: Copy and paste the following link into your web browser.

    E-Print Network [OSTI]

    Qiu, Weigang

    1 How to View Clips in the Video Clip Library: Copy and paste the following link into your." This will open a new list of links, in the navigation panel on the left. Click on "Video Analysis of Teaching". The screen to the right is the VAT homepage. In order to upload or view the lesson video that you have

  16. PPPL-3187 -Preprint: May 1996, UC-420, 426 A Procedure for Generating Quantitative 3-D Camera Views

    E-Print Network [OSTI]

    . Introduction The very high heat loads on the TPX divertor targets require continuous temperature monitoring monitoring tokamak internal components, particularly high heat flux divertor components. These models for reproducing these views. An analytic calculation of the resolution and viewing incidence angle is developed

  17. PPPL3187 Preprint: May 1996, UC420, 426 A Procedure for Generating Quantitative 3D Camera Views

    E-Print Network [OSTI]

    . Introduction The very high heat loads on the TPX divertor targets require continuous temperature monitoring monitoring tokamak internal components, particularly high heat flux divertor components. These models for reproducing these views. An analytic calculation of the resolution and viewing incidence angle is developed

  18. Neutron tube design study for boron neutron capture therapy application

    SciTech Connect (OSTI)

    Verbeke, J.M.; Lee, Y.; Leung, K.N.; Vujic, J.; Williams, M.D.; Wu, L.K.; Zahir, N.

    1999-05-06T23:59:59.000Z

    Radio-frequency (RF) driven ion sources are being developed in Lawrence Berkeley National Laboratory (LBNL) for sealed-accelerator-tube neutron generator application. By using a 5-cm-diameter RF-driven multicusp source H{sup +} yields over 95% have been achieved. These experimental findings will enable one to develop compact neutron generators based on the D-D or D-T fusion reactions. In this new neutron generator, the ion source, the accelerator and the target are all housed in a sealed metal container without external pumping. Recent moderator design simulation studies have shown that 14 MeV neutrons could be moderated to therapeutically useful energy ranges for boron neutron capture therapy (BNCT). The dose near the center of the brain with optimized moderators is about 65% higher than the dose obtained from a typical neutron spectrum produced by the Brookhaven Medical Research Reactor (BMRR), and is comparable to the dose obtained by other accelerator-based neutron sources. With a 120 keV and 1 A deuteron beam, a treatment time of {approx}35 minutes is estimated for BNCT.

  19. Electron string ion sources for carbon ion cancer therapy accelerators

    E-Print Network [OSTI]

    Boytsov, A Yu; Donets, E D; Donets, E E; Katagiri, K; Noda, K; Ponkin, D O; Ramzdorf, A Yu; Salnikov, V V; Shutov, V B

    2015-01-01T23:59:59.000Z

    The Electron String type of Ion Sources (ESIS) was developed, constructed and tested first in the Joint Institute for Nuclear Research. These ion sources can be the appropriate sources for production of pulsed C4+ and C6+ ion beams which can be used for cancer therapy accelerators. In fact the test ESIS Krion-6T already now at the solenoid magnetic field only 4.6 T provides more than 10^10 C4+ ions per pulse and about 5*10^9 C6+ ions per pulse. Such ion sources could be suitable for application at synchrotrons. It was also found, that Krion-6T can provide more than 10^11 C6+ ions per second at 100 Hz repetition rate, and the repetition rate can be increased at the same or larger ion output per second. This makes ESIS applicable at cyclotrons as well. As for production of 11C radioactive ion beams ESIS can be the most economic kind of ion source. To proof that the special cryogenic cell for pulse injection of gaseous species into electron string was successfully tested using the ESIS Krion-2M.

  20. FusionArc optimization: A hybrid volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT) planning strategy

    SciTech Connect (OSTI)

    Matuszak, Martha M.; McShan, Daniel L.; Ten Haken, Randall K. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 (United States); Steers, Jennifer M. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 and Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, Michigan 48109 (United States); Long, Troy; Edwin Romeijn, H. [Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Fraass, Benedick A. [Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California 90048 (United States)

    2013-07-15T23:59:59.000Z

    Purpose: To introduce a hybrid volumetric modulated arc therapy/intensity modulated radiation therapy (VMAT/IMRT) optimization strategy called FusionArc that combines the delivery efficiency of single-arc VMAT with the potentially desirable intensity modulation possible with IMRT.Methods: A beamlet-based inverse planning system was enhanced to combine the advantages of VMAT and IMRT into one comprehensive technique. In the hybrid strategy, baseline single-arc VMAT plans are optimized and then the current cost function gradients with respect to the beamlets are used to define a metric for predicting which beam angles would benefit from further intensity modulation. Beams with the highest metric values (called the gradient factor) are converted from VMAT apertures to IMRT fluence, and the optimization proceeds with the mixed variable set until convergence or until additional beams are selected for conversion. One phantom and two clinical cases were used to validate the gradient factor and characterize the FusionArc strategy. Comparisons were made between standard IMRT, single-arc VMAT, and FusionArc plans with one to five IMRT/hybrid beams.Results: The gradient factor was found to be highly predictive of the VMAT angles that would benefit plan quality the most from beam modulation. Over the three cases studied, a FusionArc plan with three converted beams achieved superior dosimetric quality with reductions in final cost ranging from 26.4% to 48.1% compared to single-arc VMAT. Additionally, the three beam FusionArc plans required 22.4%-43.7% fewer MU/Gy than a seven beam IMRT plan. While the FusionArc plans with five converted beams offer larger reductions in final cost-32.9%-55.2% compared to single-arc VMAT-the decrease in MU/Gy compared to IMRT was noticeably smaller at 12.2%-18.5%, when compared to IMRT.Conclusions: A hybrid VMAT/IMRT strategy was implemented to find a high quality compromise between gantry-angle and intensity-based degrees of freedom. This optimization method will allow patients to be simultaneously planned for dosimetric quality and delivery efficiency without switching between delivery techniques. Example phantom and clinical cases suggest that the conversion of only three VMAT segments to modulated beams may result in a good combination of quality and efficiency.

  1. General Electric PETtrace cyclotron as a neutron source for boron neutron capture therapy 

    E-Print Network [OSTI]

    Bosko, Andrey

    2005-11-01T23:59:59.000Z

    This research investigates the use of a PETtrace cyclotron produced by General Electric (GE) as a neutron source for boron neutron capture therapy (BNCT). The GE PETtrace was chosen for this investigation because this type of cyclotron is popular...

  2. ORIGINAL ARTICLE Retroviral vector insertions in T-lymphocytes used for suicide gene therapy

    E-Print Network [OSTI]

    Granada, Universidad de

    ORIGINAL ARTICLE Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur­ prodrug combination is the herpes simplex virus thymidine kinase (HSV-TK) gene and ganciclovir (GCV

  3. High-throughput approaches to sourcing of human hepatocytes for cell-based therapies

    E-Print Network [OSTI]

    Shan, Jing (Jing Meghan)

    2014-01-01T23:59:59.000Z

    Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...

  4. Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy

    E-Print Network [OSTI]

    Chung, Yoonsun

    2008-01-01T23:59:59.000Z

    This thesis evaluates the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro ...

  5. Group Speech Therapy in Individuals With Parkinson Disease: Face-to-Face Versus Telemedicine

    E-Print Network [OSTI]

    Wilson, Kristel Renee

    2008-07-31T23:59:59.000Z

    The purpose of this study was to evaluate the outcomes of group speech therapy for individuals with Parkinson Disease (IWPD) in general and to compare outcomes of group treatment delivered face-to-face (FtF) versus delivery ...

  6. The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2015-01-01T23:59:59.000Z

    on four cases. J Dermatolog Treat. 2009;20(5):297-8. [PMID:of photodynamic therapy to treat hidradenitis suppurativa aPDT has been used to treat other cancers and non-malignant

  7. A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy

    E-Print Network [OSTI]

    Valencia, Pedro M. (Pedro Miguel)

    2013-01-01T23:59:59.000Z

    The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

  8. Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies

    E-Print Network [OSTI]

    Wong, Albert, S.M. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    'Smart' targeted drug carriers have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited ...

  9. Moral obligation and the human germ-line gene therapy debate

    E-Print Network [OSTI]

    Clark, Alan B

    1998-01-01T23:59:59.000Z

    genetic engineering, there are few arguments made for a positive moral obligation to genetic intervention. This is especially so with respect to human germ-line gene therapy. Burke. K. Zimmerman makes one of the few arguments that society...

  10. INVESTIGATION OF THERAPY IMPROVEMENT USING REAL-TIME PHOTOACOUSTIC IMAGING GUIDED HIGH INTENSITY FOCUSED ULTRASOUND

    E-Print Network [OSTI]

    Cui, Huizhong

    2013-05-31T23:59:59.000Z

    . Thus, we further investigated the laser enhanced technique in both HIFU heating and pulsed HIFU thrombolysis. In the HIFU therapy, laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected...

  11. Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy

    E-Print Network [OSTI]

    2010-01-18T23:59:59.000Z

    , on the boundaries of bioinformatics, computational and systems biology. Results We present a simplified formalisation of the highly dynamic system consisting of HIV, TB and related therapies, at the cellular level. The progression of the disease (AIDS) depends hence...

  12. The effect of generalization of extinction on relapse following aversion therapy for alcoholism

    E-Print Network [OSTI]

    Godsey, Robert Lane

    1974-01-01T23:59:59.000Z

    THE EFFECT OF GENERALIZATION OF EXTINCTION ON REI, APSE FOLLOWING AVERSION THERAPY FOR ALCOHOLISM A Thesis by ROBERT LANE GODSEY Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE May 1974 Major Subject: Psychology THE EFFECT OF GENERALIZATION OF EXTINCTION ON RELAPSE FOLLOWING AVERSION THERAPY FOR ALCOHOLISM A Thesis ROBERT LANE GODSEY Approved as to style and content by: (Chairman of Committe...

  13. Decision Regret in Men Undergoing Dose-Escalated Radiation Therapy for Prostate Cancer

    SciTech Connect (OSTI)

    Steer, Anna N. [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia)] [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Aherne, Noel J., E-mail: noel.aherne@ncahs.health.nsw.gov.au [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour (Australia); Gorzynska, Karen; Hoffman, Matthew; Last, Andrew; Hill, Jacques [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia)] [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Shakespeare, Thomas P. [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia) [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour (Australia)

    2013-07-15T23:59:59.000Z

    Purpose: Decision regret (DR) is a negative emotion associated with medical treatment decisions, and it is an important patient-centered outcome after therapy for localized prostate cancer. DR has been found to occur in up to 53% of patients treated for localized prostate cancer, and it may vary depending on treatment modality. DR after modern dose-escalated radiation therapy (DE-RT) has not been investigated previously, to our knowledge. Our primary aim was to evaluate DR in a cohort of patients treated with DE-RT. Methods and Materials: We surveyed 257 consecutive patients with localized prostate cancer who had previously received DE-RT, by means of a validated questionnaire. Results: There were 220 responses (85.6% response rate). Image-guided intensity modulated radiation therapy was given in 85.0% of patients and 3-dimensional conformal radiation therapy in 15.0%. Doses received included 73.8 Gy (34.5% patients), 74 Gy (53.6%), and 76 Gy (10.9%). Neoadjuvant androgen deprivation (AD) was given in 51.8% of patients and both neoadjuvant and adjuvant AD in 34.5%. The median follow-up time was 23 months (range, 12-67 months). In all, 3.8% of patients expressed DR for their choice of treatment. When asked whether they would choose DE-RT or AD again, only 0.5% probably or definitely would not choose DE-RT again, compared with 8.4% for AD (P<.01). Conclusion: Few patients treated with modern DE-RT express DR, with regret appearing to be lower than in previously published reports of patients treated with radical prostatectomy or older radiation therapy techniques. Patients experienced more regret with the AD component of treatment than with the radiation therapy component, with implications for informed consent. Further research should investigate regret associated with individual components of modern therapy, including AD, radiation therapy and surgery.

  14. Basin View Geothermal Heating District, Klamath Falls, Oregon: conceptual design and economic-feasibility study report

    SciTech Connect (OSTI)

    Not Available

    1981-07-01T23:59:59.000Z

    The findings of a feasibility study performed for Basin View Heating District in Klamath Falls, Oregon are reported. The purpose of the study is to determine the physical, economic, and political feasibility of establishing a geothermal heating district to provide space heat to housing units in the Basin View Development of Klamath Falls. Of the several systems considered, all are physically feasible. The project is politically feasible if the owner compiles with governmental requirements. Economic feasibility is based on considerations of money value rates, tax rates and expected rates of return, which are dependent on government and money markets. For analysis a money value rate of 21% and an owner's marginal tax rate of 35% were adopted.

  15. Combined Ethanol Injection Therapy and Radiofrequency Ablation Therapy in Percutaneous Treatment of Hepatocellular Carcinoma Larger than 4 cm

    SciTech Connect (OSTI)

    Vallone, Paolo; Catalano, Orlando [National Cancer Institute, Department of Radiology (Italy)], E-mail: orlandcat@tin.it; Izzo, Francesco [National Cancer Institute, Department of Surgical Oncology 'D' (Italy); Siani, Alfredo [National Cancer Institute, Department of Radiology (Italy)

    2006-08-15T23:59:59.000Z

    Background. Optimal treatment of large-sized hepatocellular carcinoma (HCC) is still debated, because percutaneous ablation therapies alone do not always achieve complete necrosis. Objective. To report our experience in the treatment of patients with HCC larger than 4 cm in diameter by combined percutaneous ethanol injection and radiofrequency thermal ablation. Methods. In a 5-year period there were 40 consecutive patients meeting the inclusion criteria (24 men and 16 women; age range 41-72 years, mean 58 years). These subjects had a single HCC larger than 4 cm. Twelve subjects also had one or two additional nodules smaller than 4 cm (mean 1.2 nodules per patient). Patients were submitted to one to three sessions consisting of ethanol injection at two opposite tumor poles (mean 12 ml) and then of radiofrequency application through one or two electrodes placed at the tumor center (mean treatment duration 30 min). Results. Complete necrosis was obtained in all cases with one to three sessions (mean 1.3 sessions per patient). All patients experienced pain and fever but one only subject had a major complication requiring treatment (abscess development and fistulization). Overall follow-up was 7-69 months. Two patients showed local recurrence and 9 developed new etherotopic HCC nodules. Seven subjects died during follow-up while 33 were free from recurrence 8-69 months after treatment. Conclusion. A combination of ethanol injection and radiofrequency ablation is effective in the treatment of large HCC.

  16. Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

    SciTech Connect (OSTI)

    Sam Beddar, A.; Biggs, Peter J.; Chang Sha; Ezzell, Gary A.; Faddegon, Bruce A.; Hensley, Frank W.; Mills, Michael D. [Department of Radiation Physics, Division of Radiation Oncology, Unit 94, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 (United States); Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 (United States); Department of Radiation Oncology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259 (United States); Department of Radiation Oncology, University of California San Francisco, San Francisco, California 94143 (United States); Department of Radiation Oncology, University of Heidelberg, 69120 Heidelberg (Germany); Department of Radiation Oncology, James Graham Brown Cancer Center, Louisville, Kentucky 40202 (United States)

    2006-05-15T23:59:59.000Z

    Intraoperative radiation therapy (IORT) has been customarily performed either in a shielded operating suite located in the operating room (OR) or in a shielded treatment room located within the Department of Radiation Oncology. In both cases, this cancer treatment modality uses stationary linear accelerators. With the development of new technology, mobile linear accelerators have recently become available for IORT. Mobility offers flexibility in treatment location and is leading to a renewed interest in IORT. These mobile accelerator units, which can be transported any day of use to almost any location within a hospital setting, are assembled in a nondedicated environment and used to deliver IORT. Numerous aspects of the design of these new units differ from that of conventional linear accelerators. The scope of this Task Group (TG-72) will focus on items that particularly apply to mobile IORT electron systems. More specifically, the charges to this Task Group are to (i) identify the key differences between stationary and mobile electron linear accelerators used for IORT (ii) describe and recommend the implementation of an IORT program within the OR environment, (iii) present and discuss radiation protection issues and consequences of working within a nondedicated radiotherapy environment, (iv) describe and recommend the acceptance and machine commissioning of items that are specific to mobile electron linear accelerators, and (v) design and recommend an efficient quality assurance program for mobile systems.

  17. Conrad Aiken's manipulation of point of view in selected short stories

    E-Print Network [OSTI]

    Abbe, Margaret Ann

    1975-01-01T23:59:59.000Z

    thank Dr. Harry Kroitor for his encouragement in the preparation of this thesis and his guidance in the understanding of point of view. Finally, I went to thank my husband and my parents for their encouragement, support, and patience. viii TABIZ... of tone. Most criticisms briefly explicate Aiken'8 short stories or deal with symbolic meanings within them. Frederick Hoffman, for example, explicates several of Aiken's stories in his book Conrad Aiken and 10 also deals briefly with symbolic meaning...

  18. Private Narratives and Infant Views: Iconizing 1970s Militancy in Contemporary Argentine Cinema

    E-Print Network [OSTI]

    Garibotto, Veró nica

    2015-01-01T23:59:59.000Z

    representation, and intensifies iconicity. Or, to put it in semiotic terms, the symbolic and the indexical dimensions contribute to the process of iconization, inhibiting new affective configurations. The repetition of historically- 15 marked social...1 Private Narratives and Infant Views: Iconizing 1970s Militancy in Contemporary Argentine Cinema Shot in 2011 and released in September 2012, Infancia clandestina, by Argentine director Benjamín Ávila, has already been sold to over twenty...

  19. THE HISTORY OF US PRESIDENTIAL ELECTIONS FROM SIBERIAH HC POIHT OF VIEW

    E-Print Network [OSTI]

    Gorban, Alexander N.

    THE HISTORY OF US PRESIDENTIAL ELECTIONS FROM SIBERIAH HC POIHT OF VIEW Cory Waxman Krasnoyarsk, Krasnoyarsk-36, Russia Az. 8 5 0 2 0 U. S. A. Tests were performed with the program "US Presidential Elections systems, and may permit i t t o t r a i n tens of thousands of times f a s t e r i n c e r t a i n

  20. Assessment of industry views on international business prospects for solar thermal technology

    SciTech Connect (OSTI)

    Easterling, J.C.

    1984-09-01T23:59:59.000Z

    This report contains a review of solar thermal industry viewpoints on their prospects for developing international business. The report documents the industry's current involvement in foreign markets, view of foreign competition in overseas applications, and view of federal R and D and policy requirements to strengthen international business prospects. The report is based on discussions with equipment manufacturers and system integrators who have a product or service with potential international demand. Interviews with manufacturers and system integrators were conducted by using a standard format for interview questions. The use of a standard format for questions provided a basis for aggregating similar views expressed by US companies concerning overseas business prospects. A special effort was made to gather responses from the entire solar thermal industry, including manufacturers of line-focus, point-focus, and central receiver systems. General, technical, economic, institutional, and financial findings are provided in this summary. In addition, Pacific Northwest Laboratory (PNL) recommendations are provided (based upon advice from the Solar Thermal Review Panel) for activities to improve US solar thermal business prospects overseas.

  1. Automatic CT simulation optimization for radiation therapy: A general strategy

    SciTech Connect (OSTI)

    Li, Hua, E-mail: huli@radonc.wustl.edu; Chen, Hsin-Chen; Tan, Jun; Gay, Hiram; Michalski, Jeff M.; Mutic, Sasa [Department of Radiation Oncology, Washington University, St. Louis, Missouri 63110 (United States)] [Department of Radiation Oncology, Washington University, St. Louis, Missouri 63110 (United States); Yu, Lifeng [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States)] [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States); Anastasio, Mark A. [Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63110 (United States)] [Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63110 (United States); Low, Daniel A. [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California 90095 (United States)] [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California 90095 (United States)

    2014-03-15T23:59:59.000Z

    Purpose: In radiation therapy, x-ray computed tomography (CT) simulation protocol specifications should be driven by the treatment planning requirements in lieu of duplicating diagnostic CT screening protocols. The purpose of this study was to develop a general strategy that allows for automatically, prospectively, and objectively determining the optimal patient-specific CT simulation protocols based on radiation-therapy goals, namely, maintenance of contouring quality and integrity while minimizing patient CT simulation dose. Methods: The authors proposed a general prediction strategy that provides automatic optimal CT simulation protocol selection as a function of patient size and treatment planning task. The optimal protocol is the one that delivers the minimum dose required to provide a CT simulation scan that yields accurate contours. Accurate treatment plans depend on accurate contours in order to conform the dose to actual tumor and normal organ positions. An image quality index, defined to characterize how simulation scan quality affects contour delineation, was developed and used to benchmark the contouring accuracy and treatment plan quality within the predication strategy. A clinical workflow was developed to select the optimal CT simulation protocols incorporating patient size, target delineation, and radiation dose efficiency. An experimental study using an anthropomorphic pelvis phantom with added-bolus layers was used to demonstrate how the proposed prediction strategy could be implemented and how the optimal CT simulation protocols could be selected for prostate cancer patients based on patient size and treatment planning task. Clinical IMRT prostate treatment plans for seven CT scans with varied image quality indices were separately optimized and compared to verify the trace of target and organ dosimetry coverage. Results: Based on the phantom study, the optimal image quality index for accurate manual prostate contouring was 4.4. The optimal tube potentials for patient sizes of 38, 43, 48, 53, and 58 cm were 120, 140, 140, 140, and 140 kVp, respectively, and the corresponding minimum CTDIvol for achieving the optimal image quality index 4.4 were 9.8, 32.2, 100.9, 241.4, and 274.1 mGy, respectively. For patients with lateral sizes of 43–58 cm, 120-kVp scan protocols yielded up to 165% greater radiation dose relative to 140-kVp protocols, and 140-kVp protocols always yielded a greater image quality index compared to the same dose-level 120-kVp protocols. The trace of target and organ dosimetry coverage and the ? passing rates of seven IMRT dose distribution pairs indicated the feasibility of the proposed image quality index for the predication strategy. Conclusions: A general strategy to predict the optimal CT simulation protocols in a flexible and quantitative way was developed that takes into account patient size, treatment planning task, and radiation dose. The experimental study indicated that the optimal CT simulation protocol and the corresponding radiation dose varied significantly for different patient sizes, contouring accuracy, and radiation treatment planning tasks.

  2. MCNP speed advances for boron neutron capture therapy

    SciTech Connect (OSTI)

    Goorley, J.T.; McKinney, G.; Adams, K.; Estes, G.

    1998-04-01T23:59:59.000Z

    The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Beth Israel Deaconess Medical Center-M.I.T team relies on MCNP to determine dose rates in the subject`s head for various beam orientations. In this time consuming computational process, four or five potential beams are investigated. Of these, one or two final beams are selected and thoroughly evaluated. Recent advances greatly decreased the time needed to do these MCNP calculations. Two modifications to the new MCNP4B source code, lattice tally and tracking enhancements, reduced the wall-clock run times of a typical one million source neutrons run to one hour twenty five minutes on a 200 MHz Pentium Pro computer running Linux and using the GNU FORTRAN compiler. Previously these jobs used a special version of MCNP4AB created by Everett Redmond, which completed in two hours two minutes. In addition to this 30% speedup, the MCNP4B version was adapted for use with Parallel Virtual Machine (PVM) on personal computers running the Linux operating system. MCNP, using PVM, can be run on multiple computers simultaneously, offering a factor of speedup roughly the same as the number of computers used. With two 200 MHz Pentium Pro machines, the run time was reduced to forty five minutes, a 1.9 factor of improvement over the single Linux computer. While the time of a single run was greatly reduced, the advantages associated with PVM derive from using computational power not already used. Four possible beams, currently requiring four separate runs, could be run faster when each is individually run on a single machine under Windows NT, rather than using Linux and PVM to run one after another with each multiprocessed across four computers. It would be advantageous, however, to use PVM to distribute the final two beam orientations over four computers.

  3. Intensity Modulated Radiation Therapy With Dose Painting to Treat Rhabdomyosarcoma

    SciTech Connect (OSTI)

    Yang, Joanna C.; Dharmarajan, Kavita V. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wexler, Leonard H. [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); La Quaglia, Michael P. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Happersett, Laura [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2012-11-01T23:59:59.000Z

    Purpose: To examine local control and patterns of failure in rhabdomyosarcoma patients treated with intensity modulated radiation therapy (RT) with dose painting (DP-IMRT). Patients and Methods: A total of 41 patients underwent DP-IMRT with chemotherapy for definitive treatment. Nineteen also underwent surgery with or without intraoperative RT. Fifty-six percent had alveolar histologic features. The median interval from beginning chemotherapy to RT was 17 weeks (range, 4-25). Very young children who underwent second-look procedures with or without intraoperative RT received reduced doses of 24-36 Gy in 1.4-1.8-Gy fractions. Young adults received 50.4 Gy to the primary tumor and lower doses of 36 Gy in 1.8-Gy fractions to at-risk lymph node chains. Results: With 22 months of median follow-up, the actuarial local control rate was 90%. Patients aged {<=}7 years who received reduced overall and fractional doses had 100% local control, and young adults had 79% (P=.07) local control. Three local failures were identified in young adults whose primary target volumes had received 50.4 Gy in 1.8-Gy fractions. Conclusions: DP-IMRT with lower fractional and cumulative doses is feasible for very young children after second-look procedures with or without intraoperative RT. DP-IMRT is also feasible in adolescents and young adults with aggressive disease who would benefit from prophylactic RT to high-risk lymph node chains, although dose escalation might be warranted for improved local control. With limited follow-up, it appears that DP-IMRT produces local control rates comparable to those of sequential IMRT in patients with rhabdomyosarcoma.

  4. Adjuvant Therapy for Gallbladder Carcinoma: The Mayo Clinic Experience

    SciTech Connect (OSTI)

    Gold, Douglas G. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Miller, Robert C. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States)], E-mail: miller.robert@mayo.edu; Haddock, Michael G. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Gunderson, Leonard L. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona (United States); Quevedo, Fernando [Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota (United States); Donohue, John H. [Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota (United States); Bhatia, Sumita [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Nagorney, David M. [Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota (United States)

    2009-09-01T23:59:59.000Z

    Purpose: To analyze the effect of adjuvant chemoradiotherapy on gallbladder carcinoma. Methods and Materials: We retrospectively reviewed the records from consecutive patients who underwent R0 resection of gallbladder carcinoma between January 1, 1985, and December 31, 2004. Patients had either Stage I (T1-T2N0M0) or Stage II (T3N0M0 or T1-T3N1M0) disease. Patients undergoing adjuvant therapy received 5-fluorouracil chemotherapy concurrently with radiotherapy (median dosage, 50.4 Gy in 28 fractions). Adverse prognostic factors and the effect of adjuvant treatment on overall survival (OS) were evaluated. Results: A total of 73 patients were included in the analysis; of these, 25 received adjuvant chemoradiotherapy. On univariate analysis, no adverse prognostic factors for OS reached statistical significance, but trends were noted for Stage N1 vs. N0 (p = .06), Nx vs. N0 (p = .09), Stage T3 vs. T1-T2 (p = .06), and histologic findings other than adenocarcinoma (p = .13). The median OS for patients receiving adjuvant chemoradiotherapy vs. surgery alone was 4.8 years and 4.2 years, respectively (log-rank test, p = .56). However, a significantly greater percentage of patients receiving adjuvant chemoradiotherapy had Stage II disease (p <.001). In the multivariate Cox model, increasing T and N category and histologic findings other than adenocarcinoma were significant predictors of decreased OS. Additionally, adjuvant chemoradiotherapy was a significant predictor of improved OS after adjusting for these prognostic factors (hazard ratio for death, 0.3; 95% confidence interval, 0.13-0.69; p = .004). Conclusion: After adjusting for the stage parameters and histologic findings, our data suggest that adjuvant chemoradiotherapy might improve OS for patients with gallbladder cancer.

  5. SU-E-T-28: A Treatment Planning Comparison of Volumetric Modulated Arc Therapy Vs. Proton Therapy for Post-Mastectomy Radiotherapy

    SciTech Connect (OSTI)

    Hernandez, M; Zhang, R; Sanders, M; Newhauser, W [Louisiana State University, Baton Rouge, LA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: The delivery of post-mastectomy radiotherapy (PMRT) can be challenging for patients with left-sided breast cancer due to the PTV size and proximity to critical organs. This study investigates the use of protons for PMRT in a clinically-representative cohort of patients, and quantitatively compares volumetric modulated arc therapy (VMAT) to proton therapy to have an evidence-based rationale for selecting a treatment modality for these patients. Methods: Eight left-sided PMRT patients previously treated at our clinic with VMAT were identified for the study. PTVs included the chest wall and regional lymph nodes. Passively scattered (PS) and intensity modulated proton therapy (IMPT) plans were constructed using the Eclipse proton planning system. The resulting plans were compared to the original VMAT plan on the basis of PTV coverage; dose homogeneity index (DHI) and conformity index (CI); dose to organs at risk (OAR); tumor control probability (TCP), normal tissue complication probability (NTCP) and secondary cancer complication probability (SCCP). Differences were tested for significance using the paired Student's t-test (p<0.01). Results: All modalities produced clinically acceptable PMRT plans. The comparison demonstrated proton treatment plans provide significantly lower NTCP values for the heart and the lung while maintaining significantly better CI and DHI. At a prescribed dose of 50.4 Gy (RBE) in the PTV, the calculated mean NTCP value for the patients decreased from 1.3% to 0.05% for the whole heart (cardiac mortality) and from 3.8% to 1.1% for the lungs (radiation pneumonitis) for both proton therapy plans from VMAT plans. Both proton modalities showed a significantly lower SCCP for the contralateral breast compared to VMAT. Conclusion: All three plans (VMAT, PS, and IMPT) provide acceptable treatment plans for PMRT. However, proton therapy shows a significant advantage over VMAT with regards to sparing OARs and may be more advantageous for patients with unfavorable anatomy.

  6. Tobacco Smoking During Radiation Therapy for Head-and-Neck Cancer Is Associated With Unfavorable Outcome

    SciTech Connect (OSTI)

    Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.ed [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Chen, Leon M.; Vaughan, Andrew; Sreeraman, Radhika [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Farwell, D. Gregory; Luu, Quang [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States); Lau, Derick H. [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Stuart, Kerri; Purdy, James A.; Vijayakumar, Srinivasan [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)

    2011-02-01T23:59:59.000Z

    Purpose: To evaluate the effect of continued cigarette smoking among patients undergoing radiation therapy for head-and-neck cancer by comparing the clinical outcomes among active smokers and quitters. Methods and Materials: A review of medical records identified 101 patients with newly diagnosed squamous cell carcinoma of the head and neck who continued to smoke during radiation therapy. Each active smoker was matched to a control patient who had quit smoking before initiation of radiation therapy. Matching was based on tobacco history (pack-years), primary site, age, sex, Karnofsky Performance Status, disease stage, radiation dose, chemotherapy use, year of treatment, and whether surgical resection was performed. Outcomes were compared by use of Kaplan-Meier analysis. Normal tissue effects were graded according to the Radiation Therapy Oncology Group/European Organization for the Treatment of Cancer toxicity criteria. Results: With a median follow-up of 49 months, active smokers had significantly inferior 5-year overall survival (23% vs. 55%), locoregional control (58% vs. 69%), and disease-free survival (42% vs. 65%) compared with the former smokers who had quit before radiation therapy (p < 0.05 for all). These differences remained statistically significant when patients treated by postoperative or definitive radiation therapy were analyzed separately. The incidence of Grade 3 or greater late complications was also significantly increased among active smokers compared with former smokers (49% vs. 31%, p = 0.01). Conclusions: Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcomes. Further studies analyzing the biologic and molecular reasons underlying these differences are planned.

  7. Technological Advancements and Error Rates in Radiation Therapy Delivery

    SciTech Connect (OSTI)

    Margalit, Danielle N., E-mail: dmargalit@partners.org [Harvard Radiation Oncology Program, Boston, MA (United States); Harvard Cancer Consortium and Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, MA (United States); Chen, Yu-Hui; Catalano, Paul J.; Heckman, Kenneth; Vivenzio, Todd; Nissen, Kristopher; Wolfsberger, Luciant D.; Cormack, Robert A.; Mauch, Peter; Ng, Andrea K. [Harvard Cancer Consortium and Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, MA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: Technological advances in radiation therapy (RT) delivery have the potential to reduce errors via increased automation and built-in quality assurance (QA) safeguards, yet may also introduce new types of errors. Intensity-modulated RT (IMRT) is an increasingly used technology that is more technically complex than three-dimensional (3D)-conformal RT and conventional RT. We determined the rate of reported errors in RT delivery among IMRT and 3D/conventional RT treatments and characterized the errors associated with the respective techniques to improve existing QA processes. Methods and Materials: All errors in external beam RT delivery were prospectively recorded via a nonpunitive error-reporting system at Brigham and Women's Hospital/Dana Farber Cancer Institute. Errors are defined as any unplanned deviation from the intended RT treatment and are reviewed during monthly departmental quality improvement meetings. We analyzed all reported errors since the routine use of IMRT in our department, from January 2004 to July 2009. Fisher's exact test was used to determine the association between treatment technique (IMRT vs. 3D/conventional) and specific error types. Effect estimates were computed using logistic regression. Results: There were 155 errors in RT delivery among 241,546 fractions (0.06%), and none were clinically significant. IMRT was commonly associated with errors in machine parameters (nine of 19 errors) and data entry and interpretation (six of 19 errors). IMRT was associated with a lower rate of reported errors compared with 3D/conventional RT (0.03% vs. 0.07%, p = 0.001) and specifically fewer accessory errors (odds ratio, 0.11; 95% confidence interval, 0.01-0.78) and setup errors (odds ratio, 0.24; 95% confidence interval, 0.08-0.79). Conclusions: The rate of errors in RT delivery is low. The types of errors differ significantly between IMRT and 3D/conventional RT, suggesting that QA processes must be uniquely adapted for each technique. There was a lower error rate with IMRT compared with 3D/conventional RT, highlighting the need for sustained vigilance against errors common to more traditional treatment techniques.

  8. Direct aperture optimization for online adaptive radiation therapy

    SciTech Connect (OSTI)

    Mestrovic, Ante; Milette, Marie-Pierre; Nichol, Alan; Clark, Brenda G.; Otto, Karl [Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada and Medical Physics, BC Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada); Physics and Astronomy, University of British Columbia, Vancouver, British Columbia (Canada) and Medical Physics, BC Cancer Agency-Centre for the Southern Interior, Kelowna, British Columbia (Canada); Department of Radiation Oncology, BC Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada); Medical Physics, Ottawa Hospital Regional Cancer Centre, Ottawa, Ontario (Canada); Medical Physics, BC Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada)

    2007-05-15T23:59:59.000Z

    This paper is the first investigation of using direct aperture optimization (DAO) for online adaptive radiation therapy (ART). A geometrical model representing the anatomy of a typical prostate case was created. To simulate interfractional deformations, four different anatomical deformations were created by systematically deforming the original anatomy by various amounts (0.25, 0.50, 0.75, and 1.00 cm). We describe a series of techniques where the original treatment plan was adapted in order to correct for the deterioration of dose distribution quality caused by the anatomical deformations. We found that the average time needed to adapt the original plan to arrive at a clinically acceptable plan is roughly half of the time needed for a complete plan regeneration, for all four anatomical deformations. Furthermore, through modification of the DAO algorithm the optimization search space was reduced and the plan adaptation was significantly accelerated. For the first anatomical deformation (0.25 cm), the plan adaptation was six times more efficient than the complete plan regeneration. For the 0.50 and 0.75 cm deformations, the optimization efficiency was increased by a factor of roughly 3 compared to the complete plan regeneration. However, for the anatomical deformation of 1.00 cm, the reduction of the optimization search space during plan adaptation did not result in any efficiency improvement over the original (nonmodified) plan adaptation. The anatomical deformation of 1.00 cm demonstrates the limit of this approach. We propose an innovative approach to online ART in which the plan adaptation and radiation delivery are merged together and performed concurrently--adaptive radiation delivery (ARD). A fundamental advantage of ARD is the fact that radiation delivery can start almost immediately after image acquisition and evaluation. Most of the original plan adaptation is done during the radiation delivery, so the time spent adapting the original plan does not increase the overall time the patient has to spend on the treatment couch. As a consequence, the effective time allotted for plan adaptation is drastically reduced. For the 0.25, 0.5, and 0.75 cm anatomical deformations, the treatment time was increased by only 2, 4, and 6 s, respectively, as compared to no plan adaptation. For the anatomical deformation of 1.0 cm the time increase was substantially larger. The anatomical deformation of 1.0 cm represents an extreme case, which is rarely observed for the prostate, and again demonstrates the limit of this approach. ARD shows great potential for an online adaptive method with minimal extension of treatment time.

  9. An Inclusive View of Player Modeling Adam M. Smith, Chris Lewis, Kenneth Hullett, Gillian Smith, Anne Sullivan

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    An Inclusive View of Player Modeling Adam M. Smith, Chris Lewis, Kenneth Hullett, Gillian Smith, Anne Sullivan Center for Games and Playable Media, UC Santa Cruz Santa Cruz, CA 95064, USA {amsmith

  10. 350-?m side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus

    E-Print Network [OSTI]

    Kim, Jun Ki

    Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 ?m) graded-index optical probe with a side-view design for in ...

  11. U-Filter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani

    E-Print Network [OSTI]

    Mani, Murali

    U-Filter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani & Schuster Inc.A02 Prentice-Hall Inc.B01 McGraw-Hill Inc.A01 pubn

  12. Scalable multi-view stereo camera array for real world real-time image capture and three-dimensional displays

    E-Print Network [OSTI]

    Hill, Samuel L. (Samuel Lincoln), 1978-

    2004-01-01T23:59:59.000Z

    The number of three-dimensional displays available is escalating and yet the capturing devices for multiple view content are focused on either single camera precision rigs that are limited to stationary objects or the use ...

  13. Creating a methodology and tool to capture and resolve conflicts in developing software requirements: Requirement Lifecycle Modeling Views manager (RLMV)

    E-Print Network [OSTI]

    Herrera, Leeha Rae-Lyn

    2013-02-22T23:59:59.000Z

    tool that will aid in tracing requirements throughout the software development lifecycle. The tool, named Requirement Lifecycle Modeling Views (RLMV), follows the architecture, as defined in The Unified Modeling Language Users Guide, for modeling...

  14. Viewing the Web as a Virtual Database for Question Answering Boris Katz, Sue Felshin, Jimmy Lin, and Gregory Marton

    E-Print Network [OSTI]

    Lin, Jimmy

    , Jimmy Lin, and Gregory Marton MIT Computer Science and Artificial Intelligence Laboratory 200 Technology of this book chapter appears as: Boris Katz, Sue Felshin, Jimmy Lin, and Gregory Marton. Viewing the Web

  15. Transit of Venus: New Views of the Solar System and Galaxy Proceedings IAU Colloquium No. 196, 2004

    E-Print Network [OSTI]

    Transit of Venus: New Views of the Solar System and Galaxy Proceedings IAU Colloquium No. 196, 2004 to complement those, from the South Seas, by Green and Cook. Mason did not volunteer his services

  16. Transit of Venus: New Views of the Solar System and Galaxy Proceedings IAU Colloquium No. 196, 2004

    E-Print Network [OSTI]

    Transit of Venus: New Views of the Solar System and Galaxy Proceedings IAU Colloquium No. 196, 2004 and Cook. Mason did not volunteer his services on this occasion, possibly because of the rather o

  17. Patterns of satellite-viewed, subtropical, jet-stream clouds in relation to the observed wind field

    E-Print Network [OSTI]

    Vogt, Richard Joel

    1972-01-01T23:59:59.000Z

    PATTERNS OF SATELLITE-VIEWED, SUBTROPICAL, JET- STREAM CLOUDS IN RELATION TO THE OBSERVED WIND FIELD A Thesis by RICHARD JOEL VOGT Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE December 1972 Major Subject: Meteorology PATTERNS OP SATELLITE-VIEWED, SUBTROPICAL, JET-STREAM CLOUDS IN RELATION TO THE OBSERVED WIND FIELD A Thesis by RICHARD JOEL VOGT Approved as to style and content by: (Chairman...

  18. Adjuvant and Salvage Radiation Therapy After Prostatectomy: American Society for Radiation Oncology/American Urological Association Guidelines

    SciTech Connect (OSTI)

    Valicenti, Richard K., E-mail: Richard.valicenti@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California, Davis School of Medicine, Davis, California (United States); Thompson, Ian [Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (United States); Albertsen, Peter [Division of Urology, University of Connecticut Health Center, Farmington, Connecticut (United States); Davis, Brian J. [Department of Radiation Oncology, Mayo Medical School, Rochester, Minnesota (United States); Goldenberg, S. Larry [Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia (Canada); Wolf, J. Stuart [Department of Urology, University of Michigan, Ann Arbor, Michigan (United States); Sartor, Oliver [Department of Medicine and Urology, Tulane Medical School, New Orleans, Louisiana (United States); Klein, Eric [Glickman Urological Kidney Institute, Cleveland Clinic, Cleveland, Ohio (United States); Hahn, Carol [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Michalski, Jeff [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, San Francisco, California (United States); Faraday, Martha M. [Four Oaks, Inc (United States)

    2013-08-01T23:59:59.000Z

    Purpose: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. Methods and Materials: A systematic literature review using PubMed, Embase, and Cochrane database was conducted to identify peer-reviewed publications relevant to the use of radiation therapy after prostatectomy. The review yielded 294 articles; these publications were used to create the evidence-based guideline statements. Additional guidance is provided as Clinical Principles when insufficient evidence existed. Results: Guideline statements are provided for patient counseling, use of radiation therapy in the adjuvant and salvage contexts, defining biochemical recurrence, and conducting a restaging evaluation. Conclusions: Physicians should offer adjuvant radiation therapy to patients with adverse pathologic findings at prostatectomy (ie, seminal vesicle invastion, positive surgical margins, extraprostatic extension) and salvage radiation therapy to patients with prostate-specific antigen (PSA) or local recurrence after prostatectomy in whom there is no evidence of distant metastatic disease. The offer of radiation therapy should be made in the context of a thoughtful discussion of possible short- and long-term side effects of radiation therapy as well as the potential benefits of preventing recurrence. The decision to administer radiation therapy should be made by the patient and the multidisciplinary treatment team with full consideration of the patient's history, values, preferences, quality of life, and functional status. The American Society for Radiation Oncology and American Urological Association websites show this guideline in its entirety, including the full literature review.

  19. Wind Energy Facilities and Residential Properties: The Effect of Proximity and View on Sales Prices

    SciTech Connect (OSTI)

    Hoen, Ben; Wiser, Ryan; Cappers, Peter; Thayer, Mark; Sethi, Gautam

    2010-04-01T23:59:59.000Z

    With an increasing number of communities considering nearby wind power developments, there is a need to empirically investigate community concerns about wind project development. One such concern is that property values may be adversely affected by wind energy facilities, and relatively little research exists on the subject. The present research investigates roughly 7,500 sales of single-family homes surrounding 24 existing U.S. wind facilities. Across four different hedonic models the results are consistent: neither the view of the wind facilities nor the distance of the home to those facilities is found to have a statistically significant effect on home sales prices.

  20. Wind Energy Facilities and Residential Properties: The Effect of Proximity and View on Sales Prices

    SciTech Connect (OSTI)

    San Diego State University; Bard Center for Environmental Policy at Bard College; Hoen, Ben; Wiser, Ryan; Cappers, Peter; Thayer, Mark; Sethi, Gautam

    2011-06-23T23:59:59.000Z

    With increasing numbers of communities considering wind power developments, empirical investigations regarding related community concerns are needed. One such concern is that proximate property values may be adversely affected, yet relatively little research exists on the subject. The present research investigates roughly 7,500 sales of single-family homes surrounding 24 existing U.S. wind facilities. Across four different hedonic models, and a variety of robustness tests, the results are consistent: neither the view of the wind facilities nor the distance of the home to those facilities is found to have a statistically significant effect on sales prices, yet further research is warranted.