Sample records for integrated high throughput

  1. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01T23:59:59.000Z

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  2. Integrated Controlling System and Unified Database for High Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yu.A.; Igarashi, N.; Hiraki, M.; Sasajima, K.; Matsugaki, N.; Suzuki, M.; Kosuge, T.; Wakatsuki, S. [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba (Japan)

    2004-05-12T23:59:59.000Z

    An integrated controlling system and a unified database for high throughput protein crystallography experiments have been developed. Main features of protein crystallography experiments (purification, crystallization, crystal harvesting, data collection, data processing) were integrated into the software under development. All information necessary to perform protein crystallography experiments is stored (except raw X-ray data that are stored in a central data server) in a MySQL relational database. The database contains four mutually linked hierarchical trees describing protein crystals, data collection of protein crystal and experimental data processing. A database editor was designed and developed. The editor supports basic database functions to view, create, modify and delete user records in the database. Two search engines were realized: direct search of necessary information in the database and object oriented search. The system is based on TCP/IP secure UNIX sockets with four predefined sending and receiving behaviors, which support communications between all connected servers and clients with remote control functions (creating and modifying data for experimental conditions, data acquisition, viewing experimental data, and performing data processing). Two secure login schemes were designed and developed: a direct method (using the developed Linux clients with secure connection) and an indirect method (using the secure SSL connection using secure X11 support from any operating system with X-terminal and SSH support). A part of the system has been implemented on a new MAD beam line, NW12, at the Photon Factory Advanced Ring for general user experiments.

  3. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)

    2007-09-25T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  4. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.

    2005-07-19T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  5. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01T23:59:59.000Z

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  6. New Tools for High Throughput Chemistry and Biology 

    E-Print Network [OSTI]

    Galveia, Luciano Paulo Rosa

    2011-01-01T23:59:59.000Z

    New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...

  7. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)

    2009-09-08T23:59:59.000Z

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  8. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...

  9. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...

  10. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...

  11. Potential of High-Throughput Experimentation with Ammonia Borane...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...

  12. High throughput 3-D tissue cytometry

    E-Print Network [OSTI]

    Kwon, Hyuk-Sang, 1971-

    2007-01-01T23:59:59.000Z

    This thesis presents the ongoing technological development of high throughput 3-D tissue cytometry.and its applications in biomedicine. 3-D tissue cytometry has been developed in our laboratory based on two-photon microscopy ...

  13. High-throughput quantification of glycoprotein sialylation

    E-Print Network [OSTI]

    Markely, Lam Raga Anggara

    2011-01-01T23:59:59.000Z

    Sialic acid can improve qualities of therapeutic glycoproteins, such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method (HTM) is required for ...

  14. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint Center for...

  15. High Throughput Operando Studies using Fourier Transform Infrared...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy. High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman...

  16. High-throughput Microfluidic Screening Platforms for Microalgae Study 

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  17. Chemistry & Biology Genome-Wide High-Throughput Mining

    E-Print Network [OSTI]

    Yin, Jun

    Chemistry & Biology Article Genome-Wide High-Throughput Mining of Natural-Product Biosynthetic Gene.01.006 SUMMARY We have developed a phage-display method for high-throughput mining of bacterial gene clus- ters

  18. High-throughput Microfluidic Screening Platforms for Microalgae Study

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  19. High-Throughput, High-Precision Hot Testing Tool for High-Brightness...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting...

  20. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with a High Binding Energy (New Joint UC-BerkeleySymyx DoDDLA Project), Jeffrey Long, University of California, Berkeley High ThroughputCombinatorial Screening of Hydrogen...

  1. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...

  2. High throughput chemical munitions treatment system

    DOE Patents [OSTI]

    Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)

    2011-11-01T23:59:59.000Z

    A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.

  3. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...

  4. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust, High-Throughput

  5. ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported

    E-Print Network [OSTI]

    Senkan, Selim M.

    ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported Metal Catalysts of propylene using molecular oxygen was studied on a variety of supported metal catalysts. The most promising Propylene Á Epoxidation Á Sol­gel Á High-throughput 1 Introduction Propylene oxide (PO) is an important raw

  6. Microfluidic Technologies for High-Throughput Screening Applications

    E-Print Network [OSTI]

    Quake, Stephen R.

    Microfluidic Technologies for High-Throughput Screening Applications Thesis by Todd Thorsen, patiently giving me advice on a large variety of subjects, ranging from microfluidics to optics of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed

  7. Development and optimization of high-throughput zebrafish screening platform

    E-Print Network [OSTI]

    Koo, Bryan Kyo

    2010-01-01T23:59:59.000Z

    The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...

  8. High-Throughput Mass-Spectrometry Monitoring for Multisubstrate Enzymes

    E-Print Network [OSTI]

    Davis, Ben G.

    (EC 2.4.1.22), and the recently isolated Arabidopsis thaliana GT UGT72B1 (EC 2.4.1.-). The GAR (green a fast, high-throughput method for finding potential donors and acceptors from substrate libraries

  9. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION

    E-Print Network [OSTI]

    Steffan, J. Gregory

    Methodology 35 6.1 System Simulation . . . . . . . A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION by Jeffrey Richard Code Kingyens Code Kingyens #12;Abstract A GPU-Inspired Soft Processor for High-Throughput Acceleration Jeffrey

  10. Agenda from the U.S. Department of Energy's High Throughput Screening...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...

  11. High-throughput proteomics : optical approaches.

    SciTech Connect (OSTI)

    Davidson, George S.

    2008-09-01T23:59:59.000Z

    Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become available that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.

  12. Engineering of a High-Throughput Screening System to Identify Cellulosic Biomass,

    E-Print Network [OSTI]

    California at Riverside, University of

    - grated high-throughput (HTP) screening pipeline. Herein, we report on the engineering of a novel HTP

  13. High-ThroughputTagging of Arabidopsis Proteins

    E-Print Network [OSTI]

    Citovsky, Vitaly

    ­0124 (N.C., G.D., N.V.R.); and The Arabidopsis Information Resource (S.L., S.Y.R.) and Carnegie Institution of Washington (S.L., D.E., S.Y.R), Stanford, California 94305 We developed a high their chromogenic reac- tion products (Taylor, 1997). The use of antigenic tags, such as the T7 or HA epitopes

  14. Methods and technologies for high-throughput and high-content small animal screening

    E-Print Network [OSTI]

    Rohde, Christopher, 1979-

    2012-01-01T23:59:59.000Z

    High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...

  15. Towards Chip Scale Liquid Chromatography and High Throughput Immunosensing

    SciTech Connect (OSTI)

    Ni, J.

    2000-09-21T23:59:59.000Z

    This work describes several research projects aimed towards developing new instruments and novel methods for high throughput chemical and biological analysis. Approaches are taken in two directions. The first direction takes advantage of well-established semiconductor fabrication techniques and applies them to miniaturize instruments that are workhorses in analytical laboratories. Specifically, the first part of this work focused on the development of micropumps and microvalves for controlled fluid delivery. The mechanism of these micropumps and microvalves relies on the electrochemically-induced surface tension change at a mercury/electrolyte interface. A miniaturized flow injection analysis device was integrated and flow injection analyses were demonstrated. In the second part of this work, microfluidic chips were also designed, fabricated, and tested. Separations of two fluorescent dyes were demonstrated in microfabricated channels, based on an open-tubular liquid chromatography (OT LC) or an electrochemically-modulated liquid chromatography (EMLC) format. A reduction in instrument size can potentially increase analysis speed, and allow exceedingly small amounts of sample to be analyzed under diverse separation conditions. The second direction explores the surface enhanced Raman spectroscopy (SERS) as a signal transduction method for immunoassay analysis. It takes advantage of the improved detection sensitivity as a result of surface enhancement on colloidal gold, the narrow width of Raman band, and the stability of Raman scattering signals to distinguish several different species simultaneously without exploiting spatially-separated addresses on a biochip. By labeling gold nanoparticles with different Raman reporters in conjunction with different detection antibodies, a simultaneous detection of a dual-analyte immunoassay was demonstrated. Using this scheme for quantitative analysis was also studied and preliminary dose-response curves from an immunoassay of a mo del antigen were obtained. Simultaneous detection of several analytes at the same address can potentially increase the analysis speed, and can further expand the analysis capability of a microarray chip.

  16. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis of

  17. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis

  18. automating high-throughput blast: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  19. automated high-throughput cultivations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  20. High Throughput Pretreatment and Enzyme Hydrolysis of Biomass: Screening Recalcitrance in Large Sample Populations (Presentation)

    SciTech Connect (OSTI)

    Decker, S. R.

    2010-10-01T23:59:59.000Z

    Presentation on the execution of the first high-throughput thermochemical pretreatment/enzyme digestion pipeline for screening biomass for recalcitrance.

  1. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01T23:59:59.000Z

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  2. Interactive Visual Analysis of High Throughput Text Streams

    SciTech Connect (OSTI)

    Steed, Chad A [ORNL; Potok, Thomas E [ORNL; Patton, Robert M [ORNL; Goodall, John R [ORNL; Maness, Christopher S [ORNL; Senter, James K [ORNL

    2012-01-01T23:59:59.000Z

    The scale, velocity, and dynamic nature of large scale social media systems like Twitter demand a new set of visual analytics techniques that support near real-time situational awareness. Social media systems are credited with escalating social protest during recent large scale riots. Virtual communities form rapidly in these online systems, and they occasionally foster violence and unrest which is conveyed in the users language. Techniques for analyzing broad trends over these networks or reconstructing conversations within small groups have been demonstrated in recent years, but state-of- the-art tools are inadequate at supporting near real-time analysis of these high throughput streams of unstructured information. In this paper, we present an adaptive system to discover and interactively explore these virtual networks, as well as detect sentiment, highlight change, and discover spatio- temporal patterns.

  3. A microfluidic platform for high-throughput multiplexed protein quantitation

    E-Print Network [OSTI]

    Volpetti, Francesca; Maerkl, Sebastian

    2014-01-01T23:59:59.000Z

    We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\\b{eta}, TNF-{\\alpha}, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.

  4. High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation

    E-Print Network [OSTI]

    Zandstra, Peter W.

    High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation a microfluidic approach for high-throughput generation of 3D microenvironments with different elasticity for studies of cell fate. The generation of agarose microgels with different elastic moduli was achieved by (i

  5. Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab-Initio Calculations

    E-Print Network [OSTI]

    Curtarolo, Stefano

    Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab Database have been considered as nanograined, sintered-powder thermoelectrics with the high-throughput ab the electronic band gap and the carrier effective mass, and that the probability of having large thermoelectric

  6. High throughput energy efficient multi-FFT architecture on FPGAs (Draft)

    E-Print Network [OSTI]

    Prasanna, Viktor K.

    computing, High throughput FFT, Energy efficient design I. INTRODUCTION As FPGAs are programmed specifically in spread spec- trum receiver [4]. In the design of high throughput FFT architectures, energy-efficient design techniques can be used to maximize performance under power dissipation constraints. The power

  7. Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo}@rice.edu, yuanbinguo@huawei.com Abstract--Parallel architecture is required for high throughput turbo decoder to meet also shows great flexibility and scalability compared to prior work. Index Terms--VLSI, turbo decoder

  8. Development of Control Applications for High-Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yurii A.; Matsugaki, Naohiro; Honda, Nobuo; Sasajima, Kumiko; Igarashi, Noriyuki; Hiraki, Masahiko; Yamada, Yusuke; Wakatsuki, Soichi [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki (Japan)

    2007-01-19T23:59:59.000Z

    An integrated client-server control system (PCCS) with a unified relational database (PCDB) has been developed for high-throughput protein crystallography experiments on synchrotron beamlines. The major steps in protein crystallographic experiments (purification, crystallization, crystal harvesting, data collection, and data processing) are integrated into the software. All information necessary for performing protein crystallography experiments is stored in the PCDB database (except raw X-ray diffraction data, which is stored in the Network File Server). To allow all members of a protein crystallography group to participate in experiments, the system was developed as a multi-user system with secure network access based on TCP/IP secure UNIX sockets. Secure remote access to the system is possible from any operating system with X-terminal and SSH/X11 (Secure Shell with graphical user interface) support. Currently, the system covers the high-throughput X-ray data collection stages and is being commissioned at BL5A and NW12A (PF, PF-AR, KEK, Tsukuba, Japan)

  9. Adaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

    E-Print Network [OSTI]

    Pitsillides, Andreas

    ). The controller regulates QoS by manipulating the flow of controllable traffic into the network. Controllability. In this paper we use an adaptive feedback and feedforward control system to maximise throughput such that the QoAdaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

  10. On-chip sub-cellular resolution whole-animal manipulation for high-throughput in vivo screening

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    We present a suite of technologies that can be combined to perform complex high-throughput whole-animal genetic and drug screens. When used in various combinations, these devices facilitate a variety of high-throughput ...

  11. Solion ion source for high-efficiency, high-throughput solar cell manufacturing

    SciTech Connect (OSTI)

    Koo, John, E-mail: john-koo@amat.com; Binns, Brant; Miller, Timothy; Krause, Stephen; Skinner, Wesley; Mullin, James [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)] [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)

    2014-02-15T23:59:59.000Z

    In this paper, we introduce the Solion ion source for high-throughput solar cell doping. As the source power is increased to enable higher throughput, negative effects degrade the lifetime of the plasma chamber and the extraction electrodes. In order to improve efficiency, we have explored a wide range of electron energies and determined the conditions which best suit production. To extend the lifetime of the source we have developed an in situ cleaning method using only existing hardware. With these combinations, source life-times of >200 h for phosphorous and >100 h for boron ion beams have been achieved while maintaining 1100 cell-per-hour production.

  12. Advances in High Throughput Screening of Biomass Recalcitrance (Poster)

    SciTech Connect (OSTI)

    Turner, G. B.; Decker, S. R.; Tucker, M. P.; Law, C.; Doeppke, C.; Sykes, R. W.; Davis, M. F.; Ziebell, A.

    2012-06-01T23:59:59.000Z

    This was a poster displayed at the Symposium. Advances on previous high throughput screening of biomass recalcitrance methods have resulted in improved conversion and replicate precision. Changes in plate reactor metallurgy, improved preparation of control biomass, species-specific pretreatment conditions, and enzymatic hydrolysis parameters have reduced overall coefficients of variation to an average of 6% for sample replicates. These method changes have improved plate-to-plate variation of control biomass recalcitrance and improved confidence in sugar release differences between samples. With smaller errors plant researchers can have a higher degree of assurance more low recalcitrance candidates can be identified. Significant changes in plate reactor, control biomass preparation, pretreatment conditions and enzyme have significantly reduced sample and control replicate variability. Reactor plate metallurgy significantly impacts sugar release aluminum leaching into reaction during pretreatment degrades sugars and inhibits enzyme activity. Removal of starch and extractives significantly decreases control biomass variability. New enzyme formulations give more consistent and higher conversion levels, however required re-optimization for switchgrass. Pretreatment time and temperature (severity) should be adjusted to specific biomass types i.e. woody vs. herbaceous. Desalting of enzyme preps to remove low molecular weight stabilizers and improved conversion levels likely due to water activity impacts on enzyme structure and substrate interactions not attempted here due to need to continually desalt and validate precise enzyme concentration and activity.

  13. Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi

    E-Print Network [OSTI]

    David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar

    2014-10-10T23:59:59.000Z

    Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).

  14. ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES: SRNL GLASS SELECTION STRATEGY

    SciTech Connect (OSTI)

    Raszewski, F; Tommy Edwards, T; David Peeler, D

    2008-01-23T23:59:59.000Z

    The Department of Energy has authorized a team of glass formulation and processing experts at the Savannah River National Laboratory (SRNL), the Pacific Northwest National Laboratory (PNNL), and the Vitreous State Laboratory (VSL) at Catholic University of America to develop a systematic approach to increase high level waste melter throughput (by increasing waste loading with minimal or positive impacts on melt rate). This task is aimed at proof-of-principle testing and the development of tools to improve waste loading and melt rate, which will lead to higher waste throughput. Four specific tasks have been proposed to meet these objectives (for details, see WSRC-STI-2007-00483): (1) Integration and Oversight, (2) Crystal Accumulation Modeling (led by PNNL)/Higher Waste Loading Glasses (led by SRNL), (3) Melt Rate Evaluation and Modeling, and (4) Melter Scale Demonstrations. Task 2, Crystal Accumulation Modeling/Higher Waste Loading Glasses is the focus of this report. The objective of this study is to provide supplemental data to support the possible use of alternative melter technologies and/or implementation of alternative process control models or strategies to target higher waste loadings (WLs) for the Defense Waste Processing Facility (DWPF)--ultimately leading to higher waste throughputs and a reduced mission life. The glass selection strategy discussed in this report was developed to gain insight into specific technical issues that could limit or compromise the ability of glass formulation efforts to target higher WLs for future sludge batches at the Savannah River Site (SRS). These technical issues include Al-dissolution, higher TiO{sub 2} limits and homogeneity issues for coupled-operations, Al{sub 2}O{sub 3} solubility, and nepheline formation. To address these technical issues, a test matrix of 28 glass compositions has been developed based on 5 different sludge projections for future processing. The glasses will be fabricated and characterized based on the protocols outlined in the SRNL Task and Quality Assurance (QA) plan.

  15. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    E-Print Network [OSTI]

    Kong, Lingjie

    2013-01-01T23:59:59.000Z

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.

  16. CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy

    E-Print Network [OSTI]

    Kang, InHan

    2006-01-01T23:59:59.000Z

    In this thesis, we present a system for visualizing hierarchical, multi-dimensional, memory-intensive datasets. Specifically, we designed an interactive system to visualize data collected by high-throughput microscopy and ...

  17. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System 

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  18. Infrastructure to support ultra high throughput biodosimetry screening after a radiological event

    E-Print Network [OSTI]

    Brenner, David Jonathan

    GUY GARTY1 , ANDREW KARAM2 , & DAVID J. BRENNER3 1 Radiological Research Accelerator Facility, Radiological Research Accelerator Facility, Nevis Laboratories, Columbia UniverInfrastructure to support ultra high throughput biodosimetry screening after a radiological event

  19. Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)

    E-Print Network [OSTI]

    Xu, F.

    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...

  20. Engineering a single cell microarray platform for high throughput DNA damage and repair analysis

    E-Print Network [OSTI]

    Weingeist, David McGregor

    2012-01-01T23:59:59.000Z

    DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ...

  1. The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory

    E-Print Network [OSTI]

    Jain, Anubhav, Ph.D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...

  2. Attendees list from the U.S. Department of Energy's High Throughput...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...

  3. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01T23:59:59.000Z

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  4. An instrument for high-throughput measurements of fiber mechanical properties

    E-Print Network [OSTI]

    Kristofek, Grant William, 1980-

    2005-01-01T23:59:59.000Z

    In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...

  5. A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a

    E-Print Network [OSTI]

    Wood, Thomas K.

    A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow

  6. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  7. Optical Multiplexing for High-Throughput Spectroscopic Analysis.

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...

  8. High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup

    E-Print Network [OSTI]

    Lee, Seung-Kon

    Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...

  9. High-throughput scanning confocal microscope for single molecule Chandran R. Sabanayagam, John S. Eid, and Amit Mellera)

    E-Print Network [OSTI]

    Meller, Amit

    High-throughput scanning confocal microscope for single molecule analysis Chandran R. Sabanayagam and probing of single molecules, and an automatic focusing feature that enables the unattended scanning

  10. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Perrimon, Norbert

    Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range

  11. High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo paral- lel turbo decoder architectures have been developed. However, the interleaver has become a major that can efficiently solve the memory conflict problem for parallel turbo decoders with very high

  12. Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project application to drive grid software development. It is a flagship application for the TeraGrid project [3

  13. A Warm Near-Infrared High-Resolution Spectrograph with Very High Throughput (WINERED)

    E-Print Network [OSTI]

    Kondo, Sohei; Kobayashi, Naoto; Yasui, Chikako; Mito, Hiroyuki; Fukue, Kei; Nakanishi, Kenshi; Kawanishi, Takafumi; Nakaoka, Tetsuya; Otsubo, Shogo; Kinoshita, Masaomi; Kitano, Ayaka; Hamano, Satoshi; Mizumoto, Misaki; Yamamoto, Ryo; Izumi, Natsuko; Matsunaga, Noriyuki; Kawakita, Hideyo

    2015-01-01T23:59:59.000Z

    WINERED is a newly built high-efficiency (throughput$ > 25-30\\%$) and high-resolution spectrograph customized for short NIR bands at 0.9-1.35 ${\\rm \\mu}$m. WINERED is equipped with ambient temperature optics and a cryogenic camera using a 1.7 ${\\rm \\mu}$m cut-off HgCdTe HAWAII-2RG array detector. WINERED has two grating modes: one with a conventional reflective echelle grating (R$\\sim$28,300), which covers 0.9-1.35 $\\mu$m simultaneously, the other with ZnSe or ZnS immersion grating (R$\\sim$100,000). We have completed the development of WINERED except for the immersion grating, and started engineering and science observations at the Nasmyth platform of the 1.3 m Araki Telescope at Koyama Astronomical Observatory of Kyoto-Sangyo University in Japan. We confirmed that the spectral resolution ($R\\sim$ 28,300) and the throughput ($>$ 40\\% w/o telescope/atmosphere/array QE) meet our specifications. We measured ambient thermal backgrounds (e.g., 0.06 ${\\rm [e^{-}/sec/pixel]}$ at 287 K), which are roughly consistent ...

  14. A search model for topological insulators with high-throughput robustness descriptors

    SciTech Connect (OSTI)

    Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano

    2012-05-13T23:59:59.000Z

    Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.

  15. FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

    SciTech Connect (OSTI)

    Rathke, P.M.

    1993-09-01T23:59:59.000Z

    The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of the HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.

  16. High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays

    E-Print Network [OSTI]

    Schaffer, David V.

    High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays RANDOLPH S. ASHTON,a JOSEPH PELTIER,b CHRISTOPHER A. FASANO,c ANALEAH O'NEILL,b JOSHUA LEONARD,b SALLY TEMPLE,c DAVID. Sox2 transcription factor · Akt1 · Neural progenitor cells · Soft lithography ABSTRACT We describe

  17. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    SciTech Connect (OSTI)

    Hantke, Max, F.

    2014-11-17T23:59:59.000Z

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  18. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  19. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E.

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy more »wavelength calibration.« less

  20. Treatability studies on different refinery wastewater samples using high-throughput microbial electrolysis cells (MECs)

    E-Print Network [OSTI]

    Treatability studies on different refinery wastewater samples using high-throughput microbial, University Park, PA 16802, USA h i g h l i g h t s Refinery wastewaters were tested as fuels in MECs effective for treatment or pre-treatment of some refinery wastewaters. The best way to start up MECs

  1. Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,

    E-Print Network [OSTI]

    Basu, Amar S.

    Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest

  2. Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput

    E-Print Network [OSTI]

    Senkan, Selim M.

    Applied Catalysis A: General 254 (2003) 97­106 Photoionization detection (PID) as a high throughput 2002 Abstract A versatile photoionization detection (PID) system has been developed to rapidly screen libraries of catalytic materials. The PID approach involves the use of an appropriately selected dc

  3. A High-Throughput Method to Examine Protein-Nucleotide Interactions Identifies Targets of the Bacterial

    E-Print Network [OSTI]

    A High-Throughput Method to Examine Protein- Nucleotide Interactions Identifies Targets can easily be applied to examine multiple protein-protein, protein-nucleotide and nucleotide-nucleotide Protein-Nucleotide Interactions Identifies Targets of the Bacterial Transcriptional Regulatory Protein Fur

  4. Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical

    E-Print Network [OSTI]

    Zhu, Xiangdong

    Oblique-incidence reflectivity difference microscope for label-free high-throughput detection (OI-RD) microscope, a form of polarization-modulated imaging ellipsometer, for label on the polarizer­ compensator­sample­analyzer scheme and under the off-null condition, a polarization-modulated OI

  5. HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC

    E-Print Network [OSTI]

    Voldman, Joel

    HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC SEPARATION Michael D. Vahey conductivity. Using a re- cently developed separation method - iso-dielectric separation (IDS) - we character for developing new screens. THEORY We recently developed a separa- tion method, called iso-dielectric sepa

  6. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,

  7. automated high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of such a more database-centric approach. Roehm, Uwe 2009-01-01 31 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  8. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    groups at: U. Geneva (Switzerland), MPI (Germany), Stockholm University (Sweden), IFE (Norway), SRNL (USA), U. Tohoku, AIST (Japan) High-pressure Sintering Technique for Screening...

  9. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,

  10. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,Robust,

  11. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    having a sum of the two percentile ranks less than 30% (less than the 15 th percentile). Additional files Additionala threshold of the 15 th percentile for “highly selected”

  12. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...

  13. Uranium Transport in a High-Throughput Electrorefiner for EBR-II Blanket Fuel

    SciTech Connect (OSTI)

    Ahluwalia, Rajesh K.; Hua, Thanh Q.; Vaden, DeeEarl [Argonne National Laboratory (United States)

    2004-01-15T23:59:59.000Z

    A unique high-throughput Mk-V electrorefiner is being used in the electrometallurgical treatment of the metallic sodium-bonded blanket fuel from the Experimental Breeder Reactor II. Over many cycles, it transports uranium back and forth between the anodic fuel dissolution baskets and the cathode tubes until, because of imperfect adherence of the dendrites, it all ends up in the product collector at the bottom. The transport behavior of uranium in the high-throughput electrorefiner can be understood in terms of the sticking coefficients for uranium adherence to the cathode tubes in the forward direction and to the dissolution baskets in the reverse direction. The sticking coefficients are inferred from the experimental voltage and current traces and are correlated in terms of a single parameter representing the ratio of the cell current to the limiting current at the surface acting as the cathode. The correlations are incorporated into an engineering model that calculates the transport of uranium in the different modes of operation. The model also uses the experimentally derived electrorefiner operating maps that describe the relationship between the cell voltage and the cell current for the three principal transport modes. It is shown that the model correctly simulates the cycle-to-cycle variation of the voltage and current profiles. The model is used to conduct a parametric study of electrorefiner throughput rate as a function of the principal operating parameters. The throughput rate is found to improve with lowering of the basket rotation speed, reduction of UCl{sub 3} concentration in salt, and increasing the maximum cell current or cut-off voltage. Operating conditions are identified that can improve the throughput rate by 60 to 70% over that achieved at present.

  14. High-Throughput Analytical Model to Evaluate Materials for Temperature

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3 HanfordHarry|High-PoweredSwing

  15. Melter Throughput Enhancements for High-Iron HLW

    SciTech Connect (OSTI)

    Kruger, A. A. [Department of Energy, Office of River Protection, Richland, Washington (United States); Gan, Hoa [The Catholic University of America, Washington, DC (United States); Joseph, Innocent [The Catholic University of America, Washington, DC (United States); Pegg, Ian L. [The Catholic University of America, Washington, DC (United States); Matlack, Keith S. [The Catholic University of America, Washington, DC (United States); Chaudhuri, Malabika [The Catholic University of America, Washington, DC (United States); Kot, Wing [The Catholic University of America, Washington, DC (United States)

    2012-12-26T23:59:59.000Z

    This report describes work performed to develop and test new glass and feed formulations in order to increase glass melting rates in high waste loading glass formulations for HLW with high concentrations of iron. Testing was designed to identify glass and melter feed formulations that optimize waste loading and waste processing rate while meeting all processing and product quality requirements. The work included preparation and characterization of crucible melts to assess melt rate using a vertical gradient furnace system and to develop new formulations with enhanced melt rate. Testing evaluated the effects of waste loading on glass properties and the maximum waste loading that can be achieved. The results from crucible-scale testing supported subsequent DuraMelter 100 (DM100) tests designed to examine the effects of enhanced glass and feed formulations on waste processing rate and product quality. The DM100 was selected as the platform for these tests due to its extensive previous use in processing rate determination for various HLW streams and glass compositions.

  16. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

    SciTech Connect (OSTI)

    Hura, Greg L.; Menon, Angeli L.; Hammel, Michal; Rambo, Robert P.; Poole II, Farris L.; Tsutakawa, Susan E.; Jenney Jr, Francis E.; Classen, Scott; Frankel, Kenneth A.; Hopkins, Robert C.; Yang, Sungjae; Scott, Joseph W.; Dillard, Bret D.; Adams, Michael W. W.; Tainer, John A.

    2009-07-20T23:59:59.000Z

    We present an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering (SAXS). Our SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving. We subjected 50 representative proteins, mostly from Pyrococcus furiosus, to this pipeline and found that 30 were multimeric structures in solution. SAXS analysis allowed us to distinguish aggregated and unfolded proteins, define global structural parameters and oligomeric states for most samples, identify shapes and similar structures for 25 unknown structures, and determine envelopes for 41 proteins. We believe that high-throughput SAXS is an enabling technology that may change the way that structural genomics research is done.

  17. High Efficiency Integrated Package

    SciTech Connect (OSTI)

    Ibbetson, James

    2013-09-15T23:59:59.000Z

    Solid-state lighting based on LEDs has emerged as a superior alternative to inefficient conventional lighting, particularly incandescent. LED lighting can lead to 80 percent energy savings; can last 50,000 hours – 2-50 times longer than most bulbs; and contains no toxic lead or mercury. However, to enable mass adoption, particularly at the consumer level, the cost of LED luminaires must be reduced by an order of magnitude while achieving superior efficiency, light quality and lifetime. To become viable, energy-efficient replacement solutions must deliver system efficacies of ? 100 lumens per watt (LPW) with excellent color rendering (CRI > 85) at a cost that enables payback cycles of two years or less for commercial applications. This development will enable significant site energy savings as it targets commercial and retail lighting applications that are most sensitive to the lifetime operating costs with their extended operating hours per day. If costs are reduced substantially, dramatic energy savings can be realized by replacing incandescent lighting in the residential market as well. In light of these challenges, Cree proposed to develop a multi-chip integrated LED package with an output of > 1000 lumens of warm white light operating at an efficacy of at least 128 LPW with a CRI > 85. This product will serve as the light engine for replacement lamps and luminaires. At the end of the proposed program, this integrated package was to be used in a proof-of-concept lamp prototype to demonstrate the component’s viability in a common form factor. During this project Cree SBTC developed an efficient, compact warm-white LED package with an integrated remote color down-converter. Via a combination of intensive optical, electrical, and thermal optimization, a package design was obtained that met nearly all project goals. This package emitted 1295 lm under instant-on, room-temperature testing conditions, with an efficacy of 128.4 lm/W at a color temperature of ~2873K and 83 CRI. As such, the package’s performance exceeds DOE’s warm-white phosphor LED efficacy target for 2013. At the end of the program, we assembled an A19 sized demonstration bulb housing the integrated package which met Energy Star intensity variation requirements. With further development to reduce overall component cost, we anticipate that an integrated remote converter package such as developed during this program will find application in compact, high-efficacy LED-based lamps, particularly those requiring omnidirectional emission.

  18. Integrated microbioreactor arrays for high-throughput experimentation

    E-Print Network [OSTI]

    Lee, Harry, 1976-

    2006-01-01T23:59:59.000Z

    Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...

  19. New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site

    SciTech Connect (OSTI)

    Bhave, Ramesh R [ORNL

    2012-01-01T23:59:59.000Z

    New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site R. Bhave (Oak Ridge National Laboratory. Oak Ridge, TN) and M. R. Poirier* (Savannah River National Laboratory, Aiken SC) Solid-liquid separation is the limiting step for many waste treatment processes at the Savannah River Site. SRNL researchers have identified the rotary microfilter as a technology to improve the rate of solid-liquid separation processes. SRNL is currently developing the rotary microfilter for radioactive service and plans to deploy the technology as part of the small column ion exchange process. The rotary microfilter can utilize any filter media that is available as a flat sheet. The current baseline membrane is a 0.5 micron (nominal) porous metal filter (Pall PMM050). Previous testing with tubular filters showed that filters composed of a ceramic membrane on top of a stainless steel support produce higher flux than filters composed only of porous metal. The authors are working to develop flat sheet filter media composed of a ceramic membrane and/or ceramic-metal composite on top of a porous stainless steel support that can be used with the rotary microfilter to substantially increase filter flux resulting in a more compact, energy efficient and cost-effective high level radioactive waste treatment system. Composite membranes with precisely controlled pore size distribution were fabricated on porous metal supports. High quality uniform porous metal (316SS) supports were fabricated to achieve high water permeability. Separative layers of several different materials such as ultrafine metal particles and ceramic oxides were used to fabricate composite membranes. The fabrication process involved several high temperature heat treatments followed by characterization of gas and liquid permeability measurements and membrane integrity analysis. The fabricated composite membrane samples were evaluated in a static test cell manufactured by SpinTek. The composite membranes were evaluated on several feed slurries: 1 wt. % strontium carbonate in deionized water, 1 wt. % monosodium titanate in simulated salt solution, and 1 wt. % simulated sludge in simulated salt solution and deionized water. Flux as a function of feed flow rate and transmembrane pressure was measured for each of the above described feed slurries. The authors will discuss the new membrane development efforts, waste slurry filtration performance evaluations and scale-up considerations.

  20. Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Jordan, Scott [Physik Instrumente

    2013-02-11T23:59:59.000Z

    Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  1. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Athavale, Ajay [Monsanto

    2013-01-25T23:59:59.000Z

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  2. Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing

    E-Print Network [OSTI]

    Mueller, Tim

    Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...

  3. High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials

    E-Print Network [OSTI]

    Hautier, Geoffroy (Geoffroy T. F.)

    2011-01-01T23:59:59.000Z

    The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...

  4. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    SciTech Connect (OSTI)

    Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research

    2011-10-12T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  5. 2008NaturePublishingGrouphttp://www.nature.com/naturemethods BAC TransgeneOmics: a high-throughput method for

    E-Print Network [OSTI]

    Cai, Long

    to assess protein function at high throughput. Here we describe a fast and reliable pipeline to study ubiquitous or tissue-specific promoters. As a result they do not reproduce the endogenous regulation

  6. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    ScienceCinema (OSTI)

    Gore, Brooklin [Morgridge Institute for Research

    2013-01-22T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  7. Coev2Net: a computational framework for boosting confidence in high-throughput protein-protein interaction datasets

    E-Print Network [OSTI]

    Hosur, Raghavendra

    Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a ...

  8. A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using He+ 30.4nm

    E-Print Network [OSTI]

    California at Berkeley, University of

    A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using Entrance slit farm with ~ 1000 slits Photon counting imager Concave grating used near normal incidence >> Need a higher throughput diffuse EUV spectrometer solar wind respond to coronal

  9. High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins

    DOE Patents [OSTI]

    Kim, Sung-Hou (Moraga, CA); Kim, Rosalind (Moraga, CA); Jancarik, Jamila (Walnut Creek, CA)

    2012-01-31T23:59:59.000Z

    An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.

  10. Getter sputtering system for high-throughput fabrication of composition spreads

    SciTech Connect (OSTI)

    Gregoire, John M.; Dover, R. B. van; Jin Jing; Di Salvo, Francis J.; Abruna, Hector D. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States)

    2007-07-15T23:59:59.000Z

    We describe a sputtering system that can deposit composition spreads in an effectively UHV environment but which does not require the high-throughput paradigm to be compromised by a long pump down each time a target is changed. The system deploys four magnetron sputter guns in a cryoshroud (getter sputtering) which allows elements such as Ti and Zr to be deposited with minimal contamination by oxygen or other reactive background gases. The system also relies on custom substrate heaters to give rapid heating and cool down. The effectiveness of the gettering technique is evaluated, and example results obtained for catalytic activity of a pseudoternary composition spread are presented.

  11. High throughput ultrasoft x-ray polychromator for embedded impurity pellet injection studies

    SciTech Connect (OSTI)

    Stutman, D.; Finkenthal, M.; Delgado-Aparicio, L.; Tritz, K.; Tamura, N.; Kalinina, D.; Matsubara, A.; Sato, K.; Sudo, S. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 (United States); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan)

    2005-01-01T23:59:59.000Z

    A prototype ultrasoft x-ray polychromator has been developed for local particle transport measurements in magnetic fusion devices using the H{sub {alpha}} charge exchange emission from low-Z impurity pellets. High throughput together with few cm radial resolution in the plasma are achieved using a toroidally aligned grid collimator, while a few A spectral bandpass together with strong background rejection are obtained using planar multilayer mirrors and foil filters. As high sensitivity detectors we use a new type of compact, efficient and high-gain multichannel plates. The prototype instrument has been evaluated in the laboratory and tested on the Large Helical Device in Japan. In addition to transport studies, this type of device is of interest for next step experiments, where high beam energy and strong attenuation will make visible charge exchange recombination spectroscopy difficult.

  12. Generalized schemes for high throughput manipulation of the Desulfovibrio vulgaris Hildenborough genome

    SciTech Connect (OSTI)

    Chhabra, S.R.; Butland, G.; Elias, D.; Chandonia, J.-M.; Fok, V.; Juba, T.; Gorur, A.; Allen, S.; Leung, C.-M.; Keller, K.; Reveco, S.; Zane, G.; Semkiw, E.; Prathapam, R.; Gold, B.; Singer, M.; Ouellet, M.; Sazakal, E.; Jorgens, D.; Price, M.; Witkowska, E.; Beller, H.; Hazen, T.C.; Biggin, M.; Auer, M.; Wall, J.; Keasling, J.

    2011-07-15T23:59:59.000Z

    The ability to conduct advanced functional genomic studies of the thousands of sequenced bacteria has been hampered by the lack of available tools for making high- throughput chromosomal manipulations in a systematic manner that can be applied across diverse species. In this work, we highlight the use of synthetic biological tools to assemble custom suicide vectors with reusable and interchangeable DNA “parts” to facilitate chromosomal modification at designated loci. These constructs enable an array of downstream applications including gene replacement and creation of gene fusions with affinity purification or localization tags. We employed this approach to engineer chromosomal modifications in a bacterium that has previously proven difficult to manipulate genetically, Desulfovibrio vulgaris Hildenborough, to generate a library of over 700 strains. Furthermore, we demonstrate how these modifications can be used for examining metabolic pathways, protein-protein interactions, and protein localization. The ubiquity of suicide constructs in gene replacement throughout biology suggests that this approach can be applied to engineer a broad range of species for a diverse array of systems biological applications and is amenable to high-throughput implementation.

  13. Ultrafast, high precision gated integrator

    SciTech Connect (OSTI)

    Wang, X.

    1995-01-01T23:59:59.000Z

    An ultrafast, high precision gated integrator has been developed by introducing new design approaches that overcome the problems associated with earlier gated integrator circuits. The very high speed is evidenced by the output settling time of less than 50 ns and 20 MHz input pulse rate. The very high precision is demonstrated by the total output offset error of less than 0.2mV and the output droop rate of less than 10{mu}V/{mu}s. This paper describes the theory of this new gated integrator circuit operation. The completed circuit test results are presented.

  14. Development and operation of a high-throughput accurate-wavelength lens-based spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E., E-mail: rbell@pppl.gov [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

    2014-11-15T23:59:59.000Z

    A high-throughput spectrometer for the 400–820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  15. Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E

    2014-07-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  16. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543, USA

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  17. Evaluation of the effects of various culture condition on Cr (VI) reduction by Shewanella oneidensis MR-1 in a novel high-throughput mini-bioreactor

    E-Print Network [OSTI]

    Tang, Yinjie J.; Laidlaw, David; Gani, Kishen; Keasling, Jay D.

    2006-01-01T23:59:59.000Z

    high-throughput mini-bioreactor Yinjie Tang †,1 , Davidexamined using a mini-bioreactor system that independentlyreduction. The mini-bioreactor system enabled the rapid

  18. Learning quantitative sequence-function relationships from high-throughput biological data

    E-Print Network [OSTI]

    Atwal, Gurinder S

    2015-01-01T23:59:59.000Z

    Understanding the transcriptional regulatory code, as well as other types of information encoded within biomolecular sequences, will require learning biophysical models of sequence-function relationships from high-throughput data. Controlling and characterizing the noise in such experiments, however, is notoriously difficult. The unpredictability of such noise creates problems for standard likelihood-based methods in statistical learning, which require that the quantitative form of experimental noise be known precisely. However, when this unpredictability is properly accounted for, important theoretical aspects of statistical learning which remain hidden in standard treatments are revealed. Specifically, one finds a close relationship between the standard inference method, based on likelihood, and an alternative inference method based on mutual information. Here we review and extend this relationship. We also describe its implications for learning sequence-function relationships from real biological data. Fin...

  19. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    SciTech Connect (OSTI)

    Cuttitta, Christina M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); The City University of New York, 2800 Victory Boulevard, Staten Island, NY 10314 (United States); Ericson, Daniel L. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); University at Buffalo, SUNY, 12 Capen Hall, Buffalo, NY 14260 (United States); Scalia, Alexander [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Binghamton University, 4400 Vestal Parkway East, Binghamton, NY 11973-5000 (United States); Roessler, Christian G. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Teplitsky, Ella [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Stony Brook University, Stony Brook, NY 11794-5215 (United States); Joshi, Karan [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); PEC University of Technology, Chandigarh (India); Campos, Olven [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33414 (United States); Agarwal, Rakhi; Allaire, Marc [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Orville, Allen M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Sweet, Robert M.; Soares, Alexei S., E-mail: soares@bnl.gov [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

    2015-01-01T23:59:59.000Z

    An acoustic high-throughput screening method is described for harvesting protein crystals and combining the protein crystals with chemicals such as a fragment library. Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s{sup ?1}) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.

  20. An infrared imaging method for high-throughput combinatorial investigation of hydrogenation-dehydrogenation and new phase

    E-Print Network [OSTI]

    Rubloff, Gary W.

    An infrared imaging method for high-throughput combinatorial investigation of hydrogenation Received 9 April 2009; accepted 30 June 2009; published online 30 July 2009 We have developed an infrared imaging setup enabling in situ infrared images to be acquired, and expanded on capabilities of an infrared

  1. Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio computations

    E-Print Network [OSTI]

    Ceder, Gerbrand

    Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio (>700 Wh/kg) cathode materials for lithium-ion batteries. 1 Introduction The widespread use of lithium-ion monoclinic phase).5 However, the field of lithium-ion batteries is very active, and a large number

  2. IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 32, NO. 10, OCTOBER 2013 1791 DevStaR: High-Throughput Quantification

    E-Print Network [OSTI]

    Sontag, Eduardo

    of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C. elegans is particularly amenable to HTP the algorithmic design of the DevStaR system and demonstrate its performance in scoring image data acquired in HTP

  3. A Cross-Referencing-Based Droplet Manipulation Method for High-Throughput and Pin-Constrained Digital Microfluidic Arrays*

    E-Print Network [OSTI]

    Chakrabarty, Krishnendu

    -Constrained Digital Microfluidic Arrays* Tao Xu and Krishnendu Chakrabarty Department of Electrical and Computer Engineering Duke University, Durham, NC 27708, USA {tx, krish}@ee.duke.edu Abstract Digital microfluidic. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation

  4. been the key to their success is the use of high-throughput experiments to assess various zeo-

    E-Print Network [OSTI]

    Silver, Whendee

    it and the resulting pore structure. It could be that the hexamethonium molecules pack in such a way as to providebeen the key to their success is the use of high- throughput experiments to assess various zeo and shape of the resulting pores cor- responds to the size and shape of the organic molecule. ITQ-33

  5. Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening: Classifying the activities of various compounds towards Cobalt

    E-Print Network [OSTI]

    Kansas, University of

    Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening to the existing HTS method, via Quantitative Structure-Activity Relationship (QSAR) using Artificial Neural in solving non-linear pattern classification problems, we propose several different models of neural networks

  6. On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets

    SciTech Connect (OSTI)

    Kusne, Aaron Gilad [University of Maryland; Gao, Tieren [University of Maryland; Mehta, Apurva [SLAC National Accelerator Laboratory; Ke, Liqin [Ames Laboratory; Nguyen, Manh Cuong [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory; Antropov, Vladimir [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Kramer, Matthew J [Ames Laboratory; Long, Christian [University of Maryland; Takeuchi, Ichiro [University of Maryland

    2014-09-15T23:59:59.000Z

    Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.

  7. High-throughput liquid-absorption air-sampling apparatus and methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    2000-01-01T23:59:59.000Z

    A portable high-throughput liquid-absorption air sampler [PHTLAAS] has an asymmetric air inlet through which air is drawn upward by a small and light-weight centrifugal fan driven by a direct current motor that can be powered by a battery. The air inlet is so configured as to impart both rotational and downward components of motion to the sampled air near said inlet. The PHTLAAS comprises a glass tube of relatively small size through which air passes at a high rate in a swirling, highly turbulent motion, which facilitates rapid transfer of vapors and particulates to a liquid film covering the inner walls of the tube. The pressure drop through the glass tube is <10 cm of water, usually <5 cm of water. The sampler's collection efficiency is usually >20% for vapors or airborne particulates in the 2-3.mu. range and >50% for particles larger than 4.mu.. In conjunction with various analyzers, the PHTLAAS can serve to monitor a variety of hazardous or illicit airborne substances, such as lead-containing particulates, tritiated water vapor, biological aerosols, or traces of concealed drugs or explosives.

  8. Metal Organic Framework Research: High Throughput Discovery of Robust Metal Organic Framework for CO2 Capture

    SciTech Connect (OSTI)

    None

    2010-08-01T23:59:59.000Z

    IMPACCT Project: LBNL is developing a method for identifying the best metal organic frameworks for use in capturing CO2 from the flue gas of coal-fired power plants. Metal organic frameworks are porous, crystalline compounds that, based on their chemical structure, vary considerably in terms of their capacity to grab hold of passing CO2 molecules and their ability to withstand the harsh conditions found in the gas exhaust of coal-fired power plants. Owing primarily to their high tunability, metal organic frameworks can have an incredibly wide range of different chemical and physical properties, so identifying the best to use for CO2 capture and storage can be a difficult task. LBNL uses high-throughput instrumentation to analyze nearly 100 materials at a time, screening them for the characteristics that optimize their ability to selectively adsorb CO2 from coal exhaust. Their work will identify the most promising frameworks and accelerate their large-scale commercial development to benefit further research into reducing the cost of CO2 capture and storage.

  9. VLPW: The Very Long Packet Window Architecture for High Throughput Network-On-Chip Router Designs

    E-Print Network [OSTI]

    Gu, Haiyin

    2012-10-19T23:59:59.000Z

    -chip routers and the ideal interconnect fabric. To improve throughput, VLPW optimizes Switch Allocation (SA) efficiency. Existing SA normally applies Round-Robin scheduling to arbitrate among the packets targeting the same output port. However, this simple...

  10. High Throughput Sample Preparation and Analysis for DNA Sequencing, PCR and Combinatorial Screening of Catalysis Based on Capillary Array Technique

    SciTech Connect (OSTI)

    Yonghua Zhang

    2002-05-27T23:59:59.000Z

    Sample preparation has been one of the major bottlenecks for many high throughput analyses. The purpose of this research was to develop new sample preparation and integration approach for DNA sequencing, PCR based DNA analysis and combinatorial screening of homogeneous catalysis based on multiplexed capillary electrophoresis with laser induced fluorescence or imaging UV absorption detection. The author first introduced a method to integrate the front-end tasks to DNA capillary-array sequencers. protocols for directly sequencing the plasmids from a single bacterial colony in fused-silica capillaries were developed. After the colony was picked, lysis was accomplished in situ in the plastic sample tube using either a thermocycler or heating block. Upon heating, the plasmids were released while chromsomal DNA and membrane proteins were denatured and precipitated to the bottom of the tube. After adding enzyme and Sanger reagents, the resulting solution was aspirated into the reaction capillaries by a syringe pump, and cycle sequencing was initiated. No deleterious effect upon the reaction efficiency, the on-line purification system, or the capillary electrophoresis separation was observed, even though the crude lysate was used as the template. Multiplexed on-line DNA sequencing data from 8 parallel channels allowed base calling up to 620 bp with an accuracy of 98%. The entire system can be automatically regenerated for repeated operation. For PCR based DNA analysis, they demonstrated that capillary electrophoresis with UV detection can be used for DNA analysis starting from clinical sample without purification. After PCR reaction using cheek cell, blood or HIV-1 gag DNA, the reaction mixtures was injected into the capillary either on-line or off-line by base stacking. The protocol was also applied to capillary array electrophoresis. The use of cheaper detection, and the elimination of purification of DNA sample before or after PCR reaction, will make this approach an attractive alternative to current methods for genetic analysis and disease diagnosis.

  11. Bonus Organisms in High-Throughput Eukaryotic Whole-Genome Shorgun Assembly

    SciTech Connect (OSTI)

    Pangilinan, Jasmyn; Shapiro, Harris; Tu, Hank; Platt, Darren

    2006-02-06T23:59:59.000Z

    The DOE Joint Genome Institute has sequenced over 50 eukaryotic genomes, ranging in size from 15 MB to 1.6 GB, over a wide range of organism types. In the course of doing so, it has become clear that a substantial fraction of these data sets contains bonus organisms, usually prokaryotes, in addition to the desired genome. While some of these additional organisms are extraneous contamination, they are sometimes symbionts, and so can be of biological interest. Therefore, it is desirable to assemble the bonus organisms along with the main genome. This transforms the problem into one of metagenomic assembly, which is considerably more challenging than traditional whole-genome shotgun (WGS) assembly. The different organisms will usually be present at different sequence depths, which is difficult to handle in most WGS assemblers. In addition, with multiple distinct genomes present, chimerism can produce cross-organism combinations. Finally, there is no guarantee that only a single bonus organism will be present. For example, one JGI project contained at least two different prokaryotic contaminants, plus a 145 KB plasmid of unknown origin. We have developed techniques to routinely identify and handle such bonus organisms in a high-throughput sequencing environment. Approaches include screening and partitioning the unassembled data, and iterative subassemblies. These methods are applicable not only to bonus organisms, but also to desired components such as organelles. These procedures have the additional benefit of identifying, and allowing for the removal of, cloning artifacts such as E.coli and spurious vector inclusions.

  12. A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science

    SciTech Connect (OSTI)

    Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.

    2013-04-01T23:59:59.000Z

    We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 10×10 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.

  13. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05T23:59:59.000Z

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  14. Synthesis and characterization of four new metal 5-phosphonoisophthalates discovered by high-throughput experimentation

    SciTech Connect (OSTI)

    Bauer, Sebastian [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany); Stock, Norbert [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany)], E-mail: stock@ac.uni-kiel.de

    2007-11-15T23:59:59.000Z

    A new ligand, 5-diethylphosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2}, H{sub 2}Et{sub 2}L), for the hydrothermal synthesis of inorganic-organic hybrid compounds was prepared and characterized by NMR-spectroscopy. Its in situ hydrolysis leads to the corresponding 5-phosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H{sub 2}, H{sub 4}L). Applying high-throughput methods, different di- and trivalent metal salts for the synthesis of crystalline metal phosphonates based on H{sub 2}Et{sub 2}L have been screened. From the resulting discovery library, single-crystals of four new compounds, [Sm{sub 2}(H{sub 2}O){sub 4}(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (1), [Cu{sub 3}(H{sub 2}O)(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (2), Ca{sub 2}(H{sub 2}O)[H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H]{sub 2} (3), and Ba{sub 2}(H{sub 2}O){sub 3}(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3} (4), have been isolated. The single-crystal structure determination of the title compounds shows H{sub 4}L to be a versatile ligand, exhibiting different types of coordination modes between the functional groups and the metal ions. A comparison of the structural features of the title compounds shows a varying degree of M-O-M connectivities. Thus, isolated metal-oxygen clusters (compounds 1 and 2), infinite M-O-M chains (compound 3), and infinite M-O-M layers (compound 4) are observed. The title compounds 1, 2, and 3 were further characterized by IR-spectroscopy, TG-, EDX-, and elemental chemical analysis. - Graphical abstract: Applying high-throughput methods, the new ligand 5-diethylphosphonoisophtalic acid, (HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2} (H{sub 2}Et{sub 2}L), was reacted with several di- and trivalent metal salts under hydrothermal conditions. Single-crystals of four new inorganic-organic hybrid compounds were isolated from the discovery library. The single-crystal structure analysis shows a varying M-O-M connectivity.

  15. RESULTS OF THE FY09 ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES AT SRNL

    SciTech Connect (OSTI)

    Johnson, F.; Edwards, T.

    2010-06-23T23:59:59.000Z

    High-level waste (HLW) throughput (i.e., the amount of waste processed per unit time) is a function of two critical parameters: waste loading (WL) and melt rate. For the Waste Treatment and Immobilization Plant (WTP) at the Hanford Site and the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS), increasing HLW throughput would significantly reduce the overall mission life cycle costs for the Department of Energy (DOE). The objective of this task is to develop data, assess property models, and refine or develop the necessary models to support increased WL of HLW at SRS. It is a continuation of the studies initiated in FY07, but is under the specific guidance of a Task Change Request (TCR)/Work Authorization received from DOE headquarters (Project Number RV071301). Using the data generated in FY07, FY08 and historical data, two test matrices (60 glasses total) were developed at the Savannah River National Laboratory (SRNL) in order to generate data in broader compositional regions. These glasses were fabricated and characterized using chemical composition analysis, X-ray Diffraction (XRD), viscosity, liquidus temperature (TL) measurement and durability as defined by the Product Consistency Test (PCT). The results of this study are summarized below: (1) In general, the current durability model predicts the durabilities of higher waste loading glasses quite well. A few of the glasses exhibited poorer durability than predicted. (2) Some of the glasses exhibited anomalous behavior with respect to durability (normalized leachate for boron (NL [B])). The quenched samples of FY09EM21-02, -07 and -21 contained no nepheline or other wasteform affecting crystals, but have unacceptable NL [B] values (> 10 g/L). The ccc sample of FY09EM21-07 has a NL [B] value that is more than one half the value of the quenched sample. These glasses also have lower concentrations of Al{sub 2}O{sub 3} and SiO{sub 2}. (3) Five of the ccc samples (EM-13, -14, -15, -29 and -30) completely crystallized with both magnetite and nepheline, and still had extremely low NL [B] values. These particular glasses have more CaO present than any of the other glasses in the matrix. It appears that while all of the glasses contain nepheline, the NL [B] values decrease as the CaO concentration increases from 2.3 wt% to 4.3 wt%. A different form of nepheline may be created at higher concentrations of CaO that does not significantly reduce glass durability. (4) The T{sub L} model appears to be under-predicting the measured values of higher waste loading glasses. Trends in T{sub L} with composition are not evident in the data from these studies. (5) A small number of glasses in the FY09 matrix have measured viscosities that are much lower than the viscosity range over which the current model was developed. The decrease in viscosity is due to a higher concentration of non-bridging oxygens (NBO). A high iron concentration is the cause of the increase in NBO. Durability, viscosity and T{sub L} data collected during FY07 and FY09 that specifically targeted higher waste loading glasses was compiled and assessed. It appears that additional data may be required to expand the coverage of the T{sub L} and viscosity models for higher waste loading glasses. In general, the compositional regions of the higher waste loading glasses are very different than those used to develop these models. On the other hand, the current durability model seems to be applicable to the new data. At this time, there is no evidence to modify this model; however additional experimental studies should be conducted to determine the cause of the anomalous durability data.

  16. High-throughput two-hybrid analysis The promise and the peril

    E-Print Network [OSTI]

    Dunham, Maitreya

    , reduction in reagent costs and further refinements of the approach. As throughput escalates, so does use. The first stage is the initial description of a method: the prototype version. Typically. For a large fraction of new technologies, few other examples beyond this proto- type are ever described

  17. Throughput analysis for MIMO systems in the high SNR regime Narayan Prasad and Mahesh K. Varanasi

    E-Print Network [OSTI]

    Varanasi, Mahesh K.

    . The throughputs of MISO and SIMO fading channels are extensively analyzed and it is shown that asymptoti- cally [1, 2] and is defined as the maximum rate that can be transmitted reliably over all channel realiza rate which can be reliably transmitted This work was supported in part by NSF Grant CCF-0431170

  18. On-chip whole-animal manipulation for high-throughput subcellular-resolution in-vivo drug/genetic screening

    E-Print Network [OSTI]

    Yanik, Mehmet Fatih

    Techniques for rapid and automated small-animal manipulation and immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multicellular organisms. We present ...

  19. New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)

    ScienceCinema (OSTI)

    Notredame, Cedric [Centre for Genomic Regulation

    2011-06-08T23:59:59.000Z

    Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.

  20. Vehicle Technologies Office Merit Review 2015: High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems For Automotive Cast Magnesium Alloys

    Broader source: Energy.gov [DOE]

    Presentation given by Ohio State University at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high-throughput study...

  1. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect (OSTI)

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01T23:59:59.000Z

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  2. High Integrity Can Design Interfaces

    SciTech Connect (OSTI)

    Shaber, E.L.

    1998-08-01T23:59:59.000Z

    The National Spent Nuclear Fuel Program is chartered with facilitating the disposition of DOE-owned spent nuclear fuel to allow disposal at a geologic repository. This is done through coordination with the repository program and by assisting DOE Site owners of SNF with needed information, standardized requirements, packaging approaches, etc. The High Integrity Can (HIC) will be manufactured to provide a substitute or barrier enhancement for normal fuel geometry and cladding. The can would be nested inside the DOE standardized canister which is designed to interface with the repository waste package. The HIC approach may provide the following benefits over typical canning approaches for DOE SNF. (a) It allows ready calculation and management of criticality issues for miscellaneous. (b) It segments and further isolates damaged or otherwise problem materials from normal SNF in the repository package. (c) It provides a very long term corrosion barrier. (d) It provides an extra internal pressure barrier for particulates, gaseous fission products, hydrogen, and water vapor. (e) It delays any potential release of fission products to the repository environment. (f) It maintains an additional level of fuel geometry control during design basis accidents, rock-fall, and seismic events. (g) When seal welded, it could provide the additional containment required for shipments involving plutonium content in excess of 20 Ci. (10 CFR 71.63.b) if integrated with an appropriate cask design. Long term corrosion protection is central to the HIC concept. The material selected for the HIC (Hastelloy C-22) has undergone extensive testing for repository service. The most severe theoretical interactions between iron, repository water containing chlorides and other repository construction materials have been tested. These expected chemical species have not been shown capable of corroding the selected HIC material. Therefore, the HIC should provide a significant barrier to DOE SNF dispersal long after most commercial SNF has degraded and begun moving into the repository environment.

  3. Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

    SciTech Connect (OSTI)

    Andrew David Pris

    2003-08-05T23:59:59.000Z

    The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.

  4. High-throughput characterization of stresses in thin film materials libraries using Si cantilever array wafers and digital holographic microscopy

    SciTech Connect (OSTI)

    Lai, Y. W.; Ludwig, A. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Materials Research Department, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Hamann, S.; Ehmann, M. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany)

    2011-06-15T23:59:59.000Z

    We report the development of an advanced high-throughput stress characterization method for thin film materials libraries sputter-deposited on micro-machined cantilever arrays consisting of around 1500 cantilevers on 4-inch silicon-on-insulator wafers. A low-cost custom-designed digital holographic microscope (DHM) is employed to simultaneously monitor the thin film thickness, the surface topography and the curvature of each of the cantilevers before and after deposition. The variation in stress state across the thin film materials library is then calculated by Stoney's equation based on the obtained radii of curvature of the cantilevers and film thicknesses. DHM with nanometer-scale out-of-plane resolution allows stress measurements in a wide range, at least from several MPa to several GPa. By using an automatic x-y translation stage, the local stresses within a 4-inch materials library are mapped with high accuracy within 10 min. The speed of measurement is greatly improved compared with the prior laser scanning approach that needs more than an hour of measuring time. A high-throughput stress measurement of an as-deposited Fe-Pd-W materials library was evaluated for demonstration. The fast characterization method is expected to accelerate the development of (functional) thin films, e.g., (magnetic) shape memory materials, whose functionality is greatly stress dependent.

  5. RECENT PROCESS AND EQUIPMENT IMPROVEMENTS TO INCREASE HIGH LEVEL WASTE THROUGHPUT AT THE DEFENSE WASTE PROCESSING FACILITY

    SciTech Connect (OSTI)

    Odriscoll, R; Allan Barnes, A; Jim Coleman, J; Timothy Glover, T; Robert Hopkins, R; Dan Iverson, D; Jeff Leita, J

    2008-01-15T23:59:59.000Z

    The Savannah River Site's (SRS) Defense Waste Processing Facility (DWPF) began stabilizing high level waste (HLW) in a glass matrix in 1996. Over the past few years, there have been several process and equipment improvements at the DWPF to increase the rate at which the high level waste can be stabilized. These improvements have either directly increased waste processing rates or have desensitized the process to upsets, thereby minimizing downtime and increasing production. Improvements due to optimization of waste throughput with increased HLW loading of the glass resulted in a 6% waste throughput increase based upon operational efficiencies. Improvements in canister production include the pour spout heated bellows liner (5%), glass surge (siphon) protection software (2%), melter feed pump software logic change to prevent spurious interlocks of the feed pump with subsequent dilution of feed stock (2%) and optimization of the steam atomized scrubber (SAS) operation to minimize downtime (3%) for a total increase in canister production of 12%. A number of process recovery efforts have allowed continued operation. These include the off gas system pluggage and restoration, slurry mix evaporator (SME) tank repair and replacement, remote cleaning of melter top head center nozzle, remote melter internal inspection, SAS pump J-Tube recovery, inadvertent pour scenario resolutions, dome heater transformer bus bar cooling water leak repair and new Infra-red camera for determination of glass height in the canister are discussed.

  6. High-throughput, dual probe biological assays based on single molecule detection

    DOE Patents [OSTI]

    Hollars, Christopher W. (Brentwood, CA); Huser, Thomas R. (Livermore, CA); Lane, Stephen M. (Oakland, CA); Balhorn, Rodney L. (Livermore, CA); Bakajin, Olgica (San Leandro, CA); Darrow, Christopher (Pleasanton, CA); Satcher, Jr., Joe H. (Patterson, CA)

    2006-07-11T23:59:59.000Z

    A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 .mu.m.times.100 .mu.m.times.100 .mu.m. A device using these methods would have 10.sup.3 10.sup.4 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 .mu.m.sup.3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (.about.10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.

  7. Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry

    SciTech Connect (OSTI)

    Baker, Erin Shammel; Burnum-Johnson, Kristin E.; Jacobs, Jon M.; Diamond, Deborah L.; Brown, Roslyn N.; Ibrahim, Yehia M.; Orton, Daniel J.; Piehowski, Paul D.; Purdy, David E.; Moore, Ronald J.; Danielson, William F.; Monroe, Matthew E.; Crowell, Kevin L.; Slysz, Gordon W.; Gritsenko, Marina A.; Sandoval, John D.; Lamarche, Brian L.; Matzke, Melissa M.; Webb-Robertson, Bobbie-Jo M.; Simons, Brenna C.; McMahon, Brian J.; Bhattacharya, Renuka; Perkins, James D.; Carithers, Robert L.; Strom, Susan; Self, Steven; Katze, Michael G.; Anderson, Gordon A.; Smith, Richard D.

    2014-04-01T23:59:59.000Z

    Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is an imperative goal for the field of medicine. While mass spectrometry (MS)-based proteomics approaches have attempted to meet these objectives, challenges such as the enormous dynamic range of protein concentrations in clinically relevant biofluid samples coupled with the need to address human biodiversity have slowed their employment. Herein, we report on the use of a new platform that addresses these challenges by coupling technical advances in rapid gas phase multiplexed ion mobility spectrometry (IMS) separations [1, 2] with liquid chromatography (LC) and MS to dramatically increase measurement sensitivity and throughput, further enabling future MS-based clinical applications. An initial application of the LC-IMS-MS platform for the analysis of blood serum samples from stratified post-liver transplant patients with recurrent fibrosis progression illustrates its potential utility for disease characterization and use in personalized medicine [3, 4].

  8. Now available at the DNA Sequencing and Genotyping Core Facility OpenArray High-throughput nanofluidic PCR technology

    E-Print Network [OSTI]

    Ruvinsky, Ilya

    -throughput nanofluidic PCR technology from Life Technologies/Applied Biosystems Application/ Service Area Types · Experimental flexibility ­ open-format layout · Nanofluidic design reduces reagent usage Questions? Contact

  9. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  10. A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein-Protein

    E-Print Network [OSTI]

    ). Recent advances in chemical biology and high-throughput (HTP)1 screening (13-15) have introduced the use sensitive, robust, and widely used HTP methods for the study of protein interactions and drug discovery (19, can serve as a sensitive molecular sensor. HTP FP assays usually detect changes in polarization caused

  11. A high integrity transportable supercompactor

    SciTech Connect (OSTI)

    Sims, J.; Schmidt, G.

    1993-12-31T23:59:59.000Z

    Current transportable equipment produced to utilize high force compaction to reduce the overall volume of drums containing solid radioactive material prior to disposal, were originally designed to standards which will eventually become obsolete. At the time these machines were produced, they were state-of-the-art, but are now indicating their weaknesses in operational and safety aspects. This paper formulates a concept for a Transportable Supercompactor for handling alpha and beta/gamma bearing wastes, low operator dose uptake, contamination and radiation control systems, liquids collection, the maintenance demands of a contained press, etc., taking into account the latest technical and safety considerations. The possibility of using the concept as a skid mounted fixed Supercompactor is also reviewed in this paper.

  12. automated high-throughput platform: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the Geniom Biochip for specific elongation and labeling Cai, Long 52 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  13. array-based high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 13 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  14. aureus strains high-throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 14 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  15. antileishmanial high-throughput drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 22 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  16. Optical waveguides for microfluidic integration

    E-Print Network [OSTI]

    Ram, Rajeev J.

    A scalable polymer backplane for dense integration of photonics with lab-on-a-chip systems is presented. A high-throughput cell culture chip employing waveguides for monitoring and control of culture conditions is used to ...

  17. Technology assessment and feasibility study of high-throughput single cell force spectroscopy

    E-Print Network [OSTI]

    Cheng, He, M. Eng. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    In the last decade, the field of single cell mechanics has emerged with the development of high resolution experimental and computational methods, providing significant amount of information about individual cells instead ...

  18. Integrated Solar Thermochemical Reaction System for High Efficiency...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Integrated Solar Thermochemical Reaction System for High Efficiency Production of Electricity Integrated Solar Thermochemical Reaction System for High Efficiency Production of...

  19. High Efficiency Microturbine with Integral Heat Recovery - Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Efficiency Microturbine with Integral Heat Recovery - Presentation by Capstone Turbine Corporation, June 2011 High Efficiency Microturbine with Integral Heat Recovery -...

  20. Air-stable ink for scalable, high-throughput layer deposition

    DOE Patents [OSTI]

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11T23:59:59.000Z

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  1. Structural inference of native and partially folded RNA by high-throughput contact mapping

    E-Print Network [OSTI]

    Herschlag, Dan

    of the P4­P6 RNA that is stabilized by high concentrations of monovalent salt and whose partial order to the dynamic but otherwise similar molten globule states of proteins. With its applicability to nearly any of large RNA molecules and RNA/protein complexes. hydroxyl radical molten globule Tetrahymena ribozyme two

  2. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    SciTech Connect (OSTI)

    He, Zhili; Deng, Ye; Nostrand, Joy Van; Tu, Qichao; Xu, Meiying; Hemme, Chris; Wu, Liyou; Hazen, Terry; Zhou, Jizhong; Li, Xingyuan; Gentry, Terry; Yin, Yifeng; Liebich, Jost

    2010-05-17T23:59:59.000Z

    Microarray-based genomic technology has been widely used for microbial community analysis, and it is expected that microarray-based genomic technologies will revolutionize the analysis of microbial community structure, function and dynamics. A new generation of functional gene arrays (GeoChip 3.0) has been developed, with 27,812 probes covering 56,990 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance, and organic contaminant degradation. Those probes were derived from 2,744, 140, and 262 species for bacteria, archaea, and fungi, respectively. GeoChip 3.0 has several other distinct features, such as a common oligo reference standard (CORS) for data normalization and comparison, a software package for data management and future updating, and the gyrB gene for phylogenetic analysis. Our computational evaluation of probe specificity indicated that all designed probes had a high specificity to their corresponding targets. Also, experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036percent-0.025percent false positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which demonstrated that the structure, composition, and potential activity of soil microbial communities significantly changed with the plant species diversity. All results indicate that GeoChip 3.0 is a high throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning. To our knowledge, GeoChip 3.0 is the most comprehensive microarrays currently available for studying microbial communities associated with geobiochemical cycling, global climate change, bioenergy, agricuture, land use, ecosystem management, environmental cleanup and restoration, bioreactor systems, and human health.

  3. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform

    E-Print Network [OSTI]

    Abalde-Cela, Sara; Gould, Anna; Liu, Xin; Kazamia, Elena; Smith, Alison G.; Abell, Chris

    2015-03-17T23:59:59.000Z

    crops such as maize or sugar cane [2]. In particular, bioethanol is emerging as one of the most promising non-fossil energy resources, due to its abil- ity to be a ‘drop-in’ fuel mixed with gasoline (petrol). However, bioethanol production from sugars... obtained from arable crops requires high land areas to meet the energy requirements and so competes with land for food production. As a consequence, the need for alternative bioethanol producers is a critical issue in the biofuel field [3,4]. Microalgae...

  4. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledgeHighHighhigh

  5. Improved Algae-based Biorefining and High-throughput Screening of Algal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |HotImpact ofVisiting20143101 101

  6. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High Binding

  7. High-Throughput Program for the Discovery of NOx Reduction Catalysts |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High

  8. High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis

    SciTech Connect (OSTI)

    Wenwan Zhong

    2003-08-05T23:59:59.000Z

    Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.

  9. High Efficiency Solar Integrated Roof Membrane Product

    SciTech Connect (OSTI)

    Partyka, Eric; Shenoy, Anil

    2013-05-15T23:59:59.000Z

    This project was designed to address the Solar Energy Technology Program objective, to develop new methods to integrate photovoltaic (PV) cells or modules within a building-integrated photovoltaic (BIPV) application that will result in lower installed cost as well as higher efficiencies of the encapsulated/embedded PV module. The technology assessment and development focused on the evaluation and identification of manufacturing technologies and equipment capable of producing such low-cost, high-efficiency, flexible BIPV solar cells on single-ply roofing membranes.

  10. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    iv v vii ix x xii 3.3.1 Gradient Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  11. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev

  12. Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery

    SciTech Connect (OSTI)

    Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: ajhart@mit.edu [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-11-15T23:59:59.000Z

    Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called “Robofurnace.” Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.

  13. Highly integrated electronics for the star TPC

    SciTech Connect (OSTI)

    Arthur, A.A.; Bieser, F.; Hearn, W.; Kleinfelder, S.; Merrick, T.; Millaud, J.; Noggle, T.; Rai, G.; Ritter, H.G.; Wieman, H. [Lawrence Berkeley Laboratory, CA (United States)

    1991-12-31T23:59:59.000Z

    The concept for the STAR TPC front-end electronics is presented and the progress toward the development of a fully integrated solution is described. It is the goal of the R+D program to develop the complete electronics chain for the STAR central TPC detector at RHIC. It is obvious that solutions chosen e.g. for ALEPH are not adequate for the 150000 channels that need to be instrumented for readout. It will be necessary to perform all the signal processing, digitization and multiplexing directly on the detector in order to reduce per channel cost and the amount of cabling necessary to read out the information. We follow the approach chosen by the EOS TPC project, where the readout electronics on the detector consists of an integrated preamplifier, a hybrid shaping amplifier, an integrated switched capacitor array and a highly multiplexed ADC. The STAR electronics will be further integrated so that approximately 16 channels of the preamplifier, the shaper, the analog store and the ADC will be contained in two integrated circuits located directly on the pad plane.

  14. Highly Integrated Quality Assurance – An Empirical Case

    SciTech Connect (OSTI)

    Drake Kirkham; Amy Powell; Lucas Rich

    2011-02-01T23:59:59.000Z

    Highly Integrated Quality Assurance – An Empirical Case Drake Kirkham1, Amy Powell2, Lucas Rich3 1Quality Manager, Radioisotope Power Systems (RPS) Program, Idaho National Laboratory, P.O. Box 1625 M/S 6122, Idaho Falls, ID 83415-6122 2Quality Engineer, RPS Program, Idaho National Laboratory 3Quality Engineer, RPS Program, Idaho National Laboratory Contact: Voice: (208) 533-7550 Email: Drake.Kirkham@inl.gov Abstract. The Radioisotope Power Systems Program of the Idaho National Laboratory makes an empirical case for a highly integrated Quality Assurance function pertaining to the preparation, assembly, testing, storage and transportation of 238Pu fueled radioisotope thermoelectric generators. Case data represents multiple campaigns including the Pluto/New Horizons mission, the Mars Science Laboratory mission in progress, and other related projects. Traditional Quality Assurance models would attempt to reduce cost by minimizing the role of dedicated Quality Assurance personnel in favor of either functional tasking or peer-based implementations. Highly integrated Quality Assurance adds value by placing trained quality inspectors on the production floor side-by-side with nuclear facility operators to enhance team dynamics, reduce inspection wait time, and provide for immediate, independent feedback. Value is also added by maintaining dedicated Quality Engineers to provide for rapid identification and resolution of corrective action, enhanced and expedited supply chain interfaces, improved bonded storage capabilities, and technical resources for requirements management including data package development and Certificates of Inspection. A broad examination of cost-benefit indicates highly integrated Quality Assurance can reduce cost through the mitigation of risk and reducing administrative burden thereby allowing engineers to be engineers, nuclear operators to be nuclear operators, and the cross-functional team to operate more efficiently. Applicability of this case extends to any high-value, long-term project where traceability and accountability are determining factors.

  15. High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    E-Print Network [OSTI]

    Nieland, Thomas J.

    The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...

  16. High Throughput, Low Toxic Processing of Very Thin, High Efficiency CIGSS Solar Cells: Final Report, December 2008

    SciTech Connect (OSTI)

    Dhere, N. G.

    2009-04-01T23:59:59.000Z

    The work carried out during this project presents the use of diethylselenium or other organometallic precursors as low-toxicity alternative selenium sources for preparing a high-quality absorber.

  17. AMD 601 High Integrity -Magnesium Automotive Components (HI-MAC...

    Energy Savers [EERE]

    601 High Integrity -Magnesium Automotive Components (HI-MAC) AMD 601 High Integrity -Magnesium Automotive Components (HI-MAC) Presentation from the U.S. DOE Office of Vehicle...

  18. Photoresist integrity during high energy implant

    SciTech Connect (OSTI)

    Parrill, T.M. [Texas Instruments Productization, Dallas, TX (United States); Jones, M. [Eaton Corporation, Beverly, MA (United States); Jain, A. [Texas Indstruments Semiconductor Process and Development Center, Dallas, TX (United States)

    1996-12-31T23:59:59.000Z

    Photoresist integrity was evaluated on a commercial high-energy ion implanter operated up to the specified energy (1.7 MeV B or 3.0 MeV P) and power (1.0 MeV B at 1000 p{mu}A or 2.0 MeV P at 500 p{mu}A) limits. SEM Cross-sectional analysis of several photoresists showed that the proper cooling was maintained to avoid significant photoresist degradation. Photoresist shrinkage was observed, resulting in thickness reductions up to 22% and significant changes in sidewall slope. Little asymmetry was observed when photoresist was implanted at a 7{degrees} tilt. At the specified power limits, photoresist outgassing prevented smooth implant operation unless pressure compensation was implemented.

  19. High Efficiency Microturbine with Integral Heat Recovery - Fact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    efficiency. The microturbine technology will maximize usable exhaust energy and achieve ultra-low emissions levels. High Efficiency Microturbine with Integral Heat Recovery More...

  20. AMD 601 High Integrity -Magnesium Automotive Components (HI-MAC...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Neutral or Less Than Current Aluminum Components USAMP AMD 601 - High Integrity Magnesium Automotive Components (HI-MAC) edm2@chrysler.com February 28, 2008 Approach Scientific...

  1. High Temperature Integrated Thermoelectric Ststem and Materials

    SciTech Connect (OSTI)

    Mike S. H. Chu

    2011-06-06T23:59:59.000Z

    The final goal of this project is to produce, by the end of Phase II, an all ceramic high temperature thermoelectric module. Such a module design integrates oxide ceramic n-type, oxide ceramic p-type materials as thermoelectric legs and oxide ceramic conductive material as metalizing connection between n-type and p-type legs. The benefits of this all ceramic module are that it can function at higher temperatures (> 700 C), it is mechanically and functionally more reliable and it can be scaled up to production at lower cost. With this all ceramic module, millions of dollars in savings or in new opportunities recovering waste heat from high temperature processes could be made available. A very attractive application will be to convert exhaust heat from a vehicle to reusable electric energy by a thermoelectric generator (TEG). Phase I activities were focused on evaluating potential n-type and p-type oxide compositions as the thermoelectric legs. More than 40 oxide ceramic powder compositions were made and studied in the laboratory. The compositions were divided into 6 groups representing different material systems. Basic ceramic properties and thermoelectric properties of discs sintered from these powders were measured. Powders with different particles sizes were made to evaluate the effects of particle size reduction on thermoelectric properties. Several powders were submitted to a leading thermoelectric company for complete thermoelectric evaluation. Initial evaluation showed that when samples were sintered by conventional method, they had reasonable values of Seebeck coefficient but very low values of electrical conductivity. Therefore, their power factors (PF) and figure of merits (ZT) were too low to be useful for high temperature thermoelectric applications. An unconventional sintering method, Spark Plasma Sintering (SPS) was determined to produce better thermoelectric properties. Particle size reduction of powders also was found to have some positive benefits. Two composition systems, specifically 1.0 SrO - 0.8 x 1.03 TiO2 - 0.2 x 1.03 NbO2.5 and 0.97 TiO2 - 0.03 NbO2.5, have been identified as good base line compositions for n-type thermoelectric compositions in future module design. Tests of these materials at an outside company were promising using that company's processing and material expertise. There was no unique p-type thermoelectric compositions identified in phase I work other than several current cobaltite materials. Ca3Co4O9 will be the primary p-type material for the future module design until alternative materials are developed. BaTiO3 and rare earth titanate based dielectric compositions show both p-type and n-type behavior even though their electrical conductivities were very low. Further research and development of these materials for thermoelectric applications is planned in the future. A preliminary modeling and optimization of a thermoelectric generator (TEG) that uses the n-type 1.0 SrO - 1.03 x 0.8 TiO2 - 1.03 x 0.2 NbO2.5 was performed. Future work will combine development of ceramic powders and manufacturing expertise at TAM, development of SPS at TAM or a partner organization, and thermoelectric material/module testing, modeling, optimization, production at several partner organizations.

  2. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION Jeffrey Kingyens and J. Gregory Steffan

    E-Print Network [OSTI]

    Toronto, University of

    hardware support for up to 256 concurrent thread contexts. The key new contributions of our architecture and pipeline latency. Through simulation of a system that (i) supports AMD's CTM r5xx GPU ISA [1], and (ii RASC which integrates FPGAs into a blade server platform, and XtremeData and Nallatech that offer FPGA

  3. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

    SciTech Connect (OSTI)

    Sartipi, Sina, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Kapteijn, Freek [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)] [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)

    2013-12-15T23:59:59.000Z

    Design and operation of a “six-flow fixed-bed microreactor” setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4?mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

  4. Nanopatterning using NSOM probes integrated with high transmission nanoscale bowtie

    E-Print Network [OSTI]

    Xu, Xianfan

    Nanopatterning using NSOM probes integrated with high transmission nanoscale bowtie aperture experimental demonstration of field enhancement using such ridge antenna apertures in a bowtie shape integrated with nanoscale bowtie aperture. Consistent lines with width of 59 nm and as small as 24 nm have

  5. Nonendocytic Delivery of Functional Engineered Nanoparticles into the Cytoplasm of Live Cells Using a Novel, High-Throughput Microfluidic Device

    E-Print Network [OSTI]

    Lee, Jungmin

    The ability to straightforwardly deliver engineered nanoparticles into the cell cytosol with high viability will vastly expand the range of biological applications. Nanoparticles could potentially be used as delivery ...

  6. A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

    E-Print Network [OSTI]

    Chung, Dong-Hoon; Moore, Blake P.; Matharu, Daljit S.; Golden, Jennifer E.; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I.; Ananthan, Subramaniam; White, E. Lucile; Jia, Fuli; Jonsson, Colleen B.; Severson, William E.

    2013-01-10T23:59:59.000Z

    Background: Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 ...

  7. CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

    E-Print Network [OSTI]

    Ge, Jing

    DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced within human cells as normal cellular metabolites. Ironically, at high doses DNA damaging agents are also ...

  8. High Speed Flywheels for Integrated Energy Storage and Attitude Control

    E-Print Network [OSTI]

    Hall, Christopher D.

    High Speed Flywheels for Integrated Energy Storage and Attitude Control Christopher D. Hall. Decomposition of the space of internal torques separates the attitude control functionfrom the energy storage simultaneously performing energy storage and extraction operations. 1 Introduction The power engineering

  9. High performance CMOS integrated circuits for optical receivers

    E-Print Network [OSTI]

    SamadiBoroujeni, MohammadReza

    2009-05-15T23:59:59.000Z

    Prasad Enjeti Head of Department, Costas Georghiades December 2006 Major Subject: Electrical Engineering iii ABSTRACT High Performance CMOS Integrated Circuits for Optical Receivers. (December 2006) MohammadReza SamadiBoroujeni, B...

  10. Novel turbomachinery concepts for highly integrated airframe/propulsion systems

    E-Print Network [OSTI]

    Shah, Parthiv N

    2007-01-01T23:59:59.000Z

    Two novel turbomachinery concepts are presented as enablers to advanced flight missions requiring integrated airframe/propulsion systems. The first concept is motivated by thermal management challenges in low-to-high Mach ...

  11. AGN: The High-Energy Status before INTEGRAL

    E-Print Network [OSTI]

    W. Collmar

    2001-05-11T23:59:59.000Z

    Much progress in the knowledge of the high-energy emission (>50 keV) from Active Galactic Nuclei has been made during the last decade, predominately by the experiments aboard the Compton Gamma-Ray Observatory. After the end of the CGRO mission and prior to the upcoming INTEGRAL mission the current status of high-energy emission properties and scenarios is summarized for different AGN classes. In addition, prospects for INTEGRAL observations of AGN are given.

  12. A NOVEL LOW THERMAL BUDGET THIN-FILM POLYSILICON FABRICATION PROCESS FOR LARGE-AREA, HIGH-THROUGHPUT SOLAR CELL PRODUCTION

    SciTech Connect (OSTI)

    Yue Kuo

    2010-08-15T23:59:59.000Z

    A novel thin-film poly-Si fabrication process has been demonstrated. This low thermal budget process transforms the single- and multi-layer amorphous silicon thin films into a poly-Si structure in one simple step over a pulsed rapid thermal annealing process with the enhancement of an ultrathin Ni layer. The complete poly-Si solar cell was fabricated in a short period of time without deteriorating the underneath glass substrate. The unique vertical crystallization process including the mechanism is discussed. Influences of the dopant type and process parameters on crystal structure will be revealed. The poly-Si film structure has been proved using TEM, XRD, Raman, and XPS methods. The poly-Si solar cell structure and the performance have been examined. In principle, the new process is potentially applicable to produce large-area thin-film poly-Si solar cells at a high throughput and low cost. A critical issue in this process is to prevent the excessive dopant diffusion during crystallization. Process parameters and the cell structure have to be optimized to achieve the production goal.

  13. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    SciTech Connect (OSTI)

    Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott

    2014-09-30T23:59:59.000Z

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled “Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.” The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSep® supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  14. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    E-Print Network [OSTI]

    He, Zhili

    2010-01-01T23:59:59.000Z

    as automatic updates. 3. GeoChip 3.0 analyses showed thatindicating that GeoChip 3.0 has a high specificity.evaluation of GeoChip 3.0 A. B. Clustering analysis of nifH

  15. Development of economically viable, highly integrated, highly modular SEGIS architecture.

    SciTech Connect (OSTI)

    Enslin, Johan (Petra Solar, Inc., South Plainfield, NJ); Hamaoui, Ronald (Petra Solar, Inc., South Plainfield, NJ); Gonzalez, Sigifredo; Haddad, Ghaith (Petra Solar, Inc., South Plainfield, NJ); Rustom, Khalid (Petra Solar, Inc., South Plainfield, NJ); Stuby, Rick (Petra Solar, Inc., South Plainfield, NJ); Kuran, Mohammad (Petra Solar, Inc., South Plainfield, NJ); Mark, Evlyn (Petra Solar, Inc., South Plainfield, NJ); Amarin, Ruba (Petra Solar, Inc., South Plainfield, NJ); Alatrash, Hussam (Petra Solar, Inc., South Plainfield, NJ); Bower, Ward Isaac; Kuszmaul, Scott S.; Sena-Henderson, Lisa; David, Carolyn; Akhil, Abbas Ali

    2012-03-01T23:59:59.000Z

    Initiated in 2008, the SEGIS initiative is a partnership involving the U.S. DOE, Sandia National Laboratories, private sector companies, electric utilities, and universities. Projects supported under the initiative have focused on the complete-system development of solar technologies, with the dual goal of expanding renewable PV applications and addressing new challenges of connecting large-scale solar installations in higher penetrations to the electric grid. Petra Solar, Inc., a New Jersey-based company, received SEGIS funds to develop solutions to two of these key challenges: integrating increasing quantities of solar resources into the grid without compromising (and likely improving) power quality and reliability, and moving the design from a concept of intelligent system controls to successful commercialization. The resulting state-of-the art technology now includes a distributed photovoltaic (PV) architecture comprising AC modules that not only feed directly into the electrical grid at distribution levels but are equipped with new functions that improve voltage stability and thus enhance overall grid stability. This integrated PV system technology, known as SunWave, has applications for 'Power on a Pole,' and comes with a suite of technical capabilities, including advanced inverter and system controls, micro-inverters (capable of operating at both the 120V and 240V levels), communication system, network management system, and semiconductor integration. Collectively, these components are poised to reduce total system cost, increase the system's overall value and help mitigate the challenges of solar intermittency. Designed to be strategically located near point of load, the new SunWave technology is suitable for integration directly into the electrical grid but is also suitable for emerging microgrid applications. SunWave was showcased as part of a SEGIS Demonstration Conference at Pepco Holdings, Inc., on September 29, 2011, and is presently undergoing further field testing as a prelude to improved and expanded commercialization.

  16. BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments

    SciTech Connect (OSTI)

    Round, Adam, E-mail: around@embl.fr; Felisaz, Franck [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Fodinger, Lukas; Gobbo, Alexandre [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Huet, Julien [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Villard, Cyril [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Blanchet, Clement E., E-mail: around@embl.fr [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Pernot, Petra; McSweeney, Sean [ESRF, 6 Rue Jules Horowitz, 38000 Grenoble (France); Roessle, Manfred; Svergun, Dmitri I. [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Cipriani, Florent, E-mail: around@embl.fr [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France)

    2015-01-01T23:59:59.000Z

    A robotic sample changer for solution X-ray scattering experiments optimized for speed and to use the minimum amount of material has been developed. This system is now in routine use at three high-brilliance European synchrotron sites, each capable of several hundred measurements per day. Small-angle X-ray scattering (SAXS) of macromolecules in solution is in increasing demand by an ever more diverse research community, both academic and industrial. To better serve user needs, and to allow automated and high-throughput operation, a sample changer (BioSAXS Sample Changer) that is able to perform unattended measurements of up to several hundred samples per day has been developed. The Sample Changer is able to handle and expose sample volumes of down to 5 µl with a measurement/cleaning cycle of under 1 min. The samples are stored in standard 96-well plates and the data are collected in a vacuum-mounted capillary with automated positioning of the solution in the X-ray beam. Fast and efficient capillary cleaning avoids cross-contamination and ensures reproducibility of the measurements. Independent temperature control for the well storage and for the measurement capillary allows the samples to be kept cool while still collecting data at physiological temperatures. The Sample Changer has been installed at three major third-generation synchrotrons: on the BM29 beamline at the European Synchrotron Radiation Facility (ESRF), the P12 beamline at the PETRA-III synchrotron (EMBL@PETRA-III) and the I22/B21 beamlines at Diamond Light Source, with the latter being the first commercial unit supplied by Bruker ASC.

  17. High efficiency excitation of plasmonic waveguides with vertically integrated resonant

    E-Print Network [OSTI]

    Xu, Xianfan

    High efficiency excitation of plasmonic waveguides with vertically integrated resonant bowtie approach employs a bowtie aperture to provide both field confinement and high transmission efficiency. More than six times the power incident on the open area of the bowtie aperture can be coupled

  18. Challenges in High-throughput Data Analysis: Proteomic Data Pre-processing and Network Methods for Integrating Multiple Data Types

    E-Print Network [OSTI]

    Liao, Eileen

    2012-01-01T23:59:59.000Z

    Term Benjamini P-value Black SP_PIR_KEYWORDS phosphoprotein2.70E-07 SP_PIR_KEYWORDS alternative splicing1.50E-12 SP_PIR_KEYWORDS phosphoprotein 3.90E-07 SP_PIR_

  19. Development of high through-put Sr isotope analysis for monitoring reservoir integrity for CO{sub 2} storage.

    SciTech Connect (OSTI)

    Wall, Andy; Jain, Jinesh; Stewart, Brian; Capo, Rosemary; Hakala, Alexandra J.; Hammack, Richard; Guthrie, George

    2012-01-01T23:59:59.000Z

    Recent innovations in multi-collector ICP-mass spectrometry (MC-ICP-MS) have allowed for rapid and precise measurements of isotope ratios in geological samples. Naturally occurring Sr isotopes has the potential for use in Monitoring, Verification, and Accounting (MVA) associated with geologic CO2 storage. Sr isotopes can be useful for: Sensitive tracking of brine migration; Determining seal rock leakage; Studying fluid/rock reactions. We have optimized separation chemistry procedures that will allow operators to prepare samples for Sr isotope analysis off site using rapid, low cost methods.

  20. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    heating Module..FH Control and Resist Pre-heating Module Inspired by thecontrol and resist pre-heating module using the same laser

  1. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    optical near field from a bowtie aperture. Applied PhysicsUtilizing the near- field of bowtie optical nanoantennas.H-shaped, I-shaped and bowtie apertures. Although the

  2. Integrity of Data Samples and Results in High Energy Physics

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    plots from the Particle Data Group; each point is cum avg. #12;But there is also good in us... http articles so far; now about 1/week. · Data also contain many well understood processes that can be usedIntegrity of Data Samples and Results in High Energy Physics Jeffrey D. RichmanJeffrey D. Richman

  3. 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web-based High-Throughput Tool for Next-Generation Sequence Annotation

    E-Print Network [OSTI]

    320 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web deployed on the Mana Linux cluster at the Maui High Performance Computing Center. The two components

  4. Achieving High Reliability Operations Through Multi-Program Integration

    SciTech Connect (OSTI)

    Holly M. Ashley; Ronald K. Farris; Robert E. Richards

    2009-04-01T23:59:59.000Z

    Over the last 20 years the Idaho National Laboratory (INL) has adopted a number of operations and safety-related programs which has each periodically taken its turn in the limelight. As new programs have come along there has been natural competition for resources, focus and commitment. In the last few years, the INL has made real progress in integrating all these programs and are starting to realize important synergies. Contributing to this integration are both collaborative individuals and an emerging shared vision and goal of the INL fully maturing in its high reliability operations. This goal is so powerful because the concept of high reliability operations (and the resulting organizations) is a masterful amalgam and orchestrator of the best of all the participating programs (i.e. conduct of operations, behavior based safety, human performance, voluntary protection, quality assurance, and integrated safety management). This paper is a brief recounting of the lessons learned, thus far, at the INL in bringing previously competing programs into harmony under the goal (umbrella) of seeking to perform regularly as a high reliability organization. In addition to a brief diagram-illustrated historical review, the authors will share the INL’s primary successes (things already effectively stopped or started) and the gaps yet to be bridged.

  5. Towards Integrated Design and Modeling of High Field Accelerator Magnets

    SciTech Connect (OSTI)

    Caspi, S.; Ferracin, P.

    2006-06-01T23:59:59.000Z

    The next generation of superconducting accelerator magnets will most likely use a brittle conductor (such as Nb{sub 3}Sn), generate fields around 18 T, handle forces that are 3-4 times higher than in the present LHC dipoles, and store energy that starts to make accelerator magnets look like fusion magnets. To meet the challenge and reduce the complexity, magnet design will have to be more innovative and better integrated. The recent design of several high field superconducting magnets have now benefited from the integration between CAD (e.g. ProE), magnetic analysis tools (e.g. TOSCA) and structural analysis tools (e.g. ANSYS). Not only it is now possible to address complex issues such as stress in magnet ends, but the analysis can be better detailed an extended into new areas previously too difficult to address. Integrated thermal, electrical and structural analysis can be followed from assembly and cool-down through excitation and quench propagation. In this paper we report on the integrated design approach, discuss analysis results and point out areas of future interest.

  6. Design, Implementation and Performance of Exponential Integrators for High Performance Computing Applications

    E-Print Network [OSTI]

    Loffeld, John

    2013-01-01T23:59:59.000Z

    interest in high performance computing would help popularizeIntegrators for High Performance Computing Applications Aapplied mathematics, high performance computing and computer

  7. NREL: Energy Systems Integration Facility - High-Performance Computing and

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated CodesTransparency Visit | NationalWebmasterAnalytics High-Performance

  8. Materials integration issues for high performance fusion power systems.

    SciTech Connect (OSTI)

    Smith, D. L.

    1998-01-14T23:59:59.000Z

    One of the primary requirements for the development of fusion as an energy source is the qualification of materials for the frost wall/blanket system that will provide high performance and exhibit favorable safety and environmental features. Both economic competitiveness and the environmental attractiveness of fusion will be strongly influenced by the materials constraints. A key aspect is the development of a compatible combination of materials for the various functions of structure, tritium breeding, coolant, neutron multiplication and other special requirements for a specific system. This paper presents an overview of key materials integration issues for high performance fusion power systems. Issues such as: chemical compatibility of structure and coolant, hydrogen/tritium interactions with the plasma facing/structure/breeder materials, thermomechanical constraints associated with coolant/structure, thermal-hydraulic requirements, and safety/environmental considerations from a systems viewpoint are presented. The major materials interactions for leading blanket concepts are discussed.

  9. Verification and validation guidelines for high integrity systems. Volume 1

    SciTech Connect (OSTI)

    Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D. [SoHaR, Inc., Beverly Hills, CA (United States)

    1995-03-01T23:59:59.000Z

    High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities.

  10. Integration

    E-Print Network [OSTI]

    Koschorke, Albrecht; Musanovic, Emina

    2013-01-01T23:59:59.000Z

    Integration By Albrecht Koschorkeby Emina Musanovic [Integration (from Lat. integrare, “toa social unity. Social integration is distinct from systemic

  11. High Efficiency Current-Mode Class-DAmplifier with Integrated Resonator

    E-Print Network [OSTI]

    Asbeck, Peter M.

    THIF-54 High Efficiency Current-Mode Class-DAmplifier with Integrated Resonator Tsai-PiHung, Andre) amplifiers with integrated parallel LC resonator can achieve high efficiency at RF frequencies. In contrast to implement a high Q inductor in the LC resonator. An experimental CMCD amplifier with collector efficiency

  12. High Efficiency, Ultra-Low Emission, Integrated Process Heater System

    SciTech Connect (OSTI)

    Mason, Howard; Boral, Anindya; Chhotray, San; Martin, Matthew

    2006-06-19T23:59:59.000Z

    The team of TIAX LLC, ExxonMobil Research and Engineering Company, and Callidus Technologies, LLC conducted a six-year program to develop an ultra-low emission process heater burner and an advanced high efficiency heater design. This project addresses the critical need of process heater operators for reliable, economical emission reduction technologies to comply with stringent emission regulations, and for heater design alternatives that reduce process heater energy requirements without significant cost increase. The key project targets were NOx emissions of 10 ppm (@ 3% O2), and a heater thermal efficiency of 95 percent. The ultra low NOx burner was developed through a series of pilot-scale and field tests combined with computational fluid dynamic modeling to arrive at simultaneous low emissions and suitable flame shape and stability. Pilot scale tests were run at TIAX, at the 2 MMBtu/hr scale, and at Callidus at 8 MMBtu/hr. The full scale burner was installed on a 14 burner atmospheric pipestill furnace at an ExxonMobil refinery. A variety of burner configurations, gas tips and flame stabilizers were tested to determine the lowest emissions with acceptable flame shape and stability. The resulting NOx emissions were 22 ppm on average. Starting in 2001, Callidus commercialized the original ultra low NOx burner and made subsequent design improvements in a series of commercial burners evolving from the original concept and/or development. Emissions in the field with the ultra low-NOx burner over a broad spectrum of heater applications have varied from 5 ppm to 30 ppm depending on heater geometry, heater service, fuel and firing capacity. To date, 1550 of the original burners, and 2500 of subsequent generation burners have been sold by Callidus. The advanced heater design was developed by parametric evaluations of a variety of furnace and combustion air preheater configurations and technologies for enhancing convective and radiative heat transfer. The design evolution relied heavily on computational fluid dynamic predictions of design alternatives. The final design features modular separate radiant cells, each with one and two-side fired vertical tubes. The convection section configuration is vertical tube banks enclosed in the radiant channels. Commercial modular plate air preheaters are used. The predicted performance for the integrated advanced heater and Callidus burner is 95 percent efficiency with 9 ppm NOx emissions firing natural gas, and 12 ppm firing refinery gas. The total erected cost is less than a conventional heater with combustion air preheat.

  13. FESAC-SP Whyte New HTS superconductors + integrated high-B physics

    E-Print Network [OSTI]

    launchers & coupling G-9 Tame PMI & heat exhaust G-10-15 Integrated fusion materials & components High & innovative launchers for steady-state - High pressure boundary & PMI control Demountable HTS coils

  14. An anisotropic integral operator in high temperature superconductivity

    E-Print Network [OSTI]

    Boris Mityagin

    2008-03-21T23:59:59.000Z

    A simplified model in superconductivity theory studied by P. Krotkov and A. Chubukov \\cite{KC1,KC2} led to an integral operator $K$ -- see (1), (2). They guessed that the equation $E_0(a,T)=1$ where $E_0$ is the largest eigenvalue of the operator $K$ has a solution $T(a)=1-\\tau(a)$ with $\\tau (a) \\sim a^{2/5}$ when $a$ goes to 0. $\\tau(a)$ imitates the shift of critical (instability) temperature. We give a rigorous analysis of an anisotropic integral operator $K$ and prove the asymptotic ($*$) -- see Theorem 8 and Proposition 10. Additive Uncertainty Principle (of Landau-Pollack-Slepian [SP], \\cite{LP1,LP2}) plays important role in this analysis.

  15. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

    2000-08-22T23:59:59.000Z

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

  16. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, L.O.; Ohta, Kazuyoshi; Wood, B.E.

    1998-10-13T23:59:59.000Z

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol. 13 figs.

  17. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

    1998-01-01T23:59:59.000Z

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

  18. Integrated high efficiency blower apparatus for HVAC systems

    DOE Patents [OSTI]

    Liu, Xiaoyue; Weigman, Herman; Wang, Shixiao

    2007-07-24T23:59:59.000Z

    An integrated centrifugal blower wheel for a heating, ventilation and air conditioning (HVAC) blower unit includes a first blade support, a second blade support, and a plurality of S-shaped blades disposed between the first and second blade supports, wherein each of the S-shaped blades has a trailing edge bent in a forward direction with respect to a defined direction of rotation of the wheel.

  19. Development of integrated thermionic circuits for high-temperature applications

    SciTech Connect (OSTI)

    McCormick, J.B.; Wilde, D.; Depp, S.; Hamilton, D.J.; Kerwin, W.

    1981-01-01T23:59:59.000Z

    This report describes a class of microminiature, thin film devices known as integrated thermionic circuits (ITC) capable of extended operation in ambient temperatures up to 500/sup 0/C. The evolution of the ITC concept is discussed. A set of practical design and performance equations is demonstrated. Recent experimental results are discussed in which both devices and simple circuits have successfully operated in 500/sup 0/C environments for extended periods of time (greater than 11,000 hours).

  20. Data Integration for the Generation of High Resolution Reservoir Models

    SciTech Connect (OSTI)

    Albert Reynolds; Dean Oliver; Gaoming Li; Yong Zhao; Chaohui Che; Kai Zhang; Yannong Dong; Chinedu Abgalaka; Mei Han

    2009-01-07T23:59:59.000Z

    The goal of this three-year project was to develop a theoretical basis and practical technology for the integration of geologic, production and time-lapse seismic data in a way that makes best use of the information for reservoir description and reservoir performance predictions. The methodology and practical tools for data integration that were developed in this research project have been incorporated into computational algorithms that are feasible for large scale reservoir simulation models. As the integration of production and seismic data require calibrating geological/geostatistical models to these data sets, the main computational tool is an automatic history matching algorithm. The following specific goals were accomplished during this research. (1) We developed algorithms for calibrating the location of the boundaries of geologic facies and the distribution of rock properties so that production and time-lapse seismic data are honored. (2) We developed and implemented specific procedures for conditioning reservoir models to time-lapse seismic data. (3) We developed and implemented algorithms for the characterization of measurement errors which are needed to determine the relative weights of data when conditioning reservoir models to production and time-lapse seismic data by automatic history matching. (4) We developed and implemented algorithms for the adjustment of relative permeability curves during the history matching process. (5) We developed algorithms for production optimization which accounts for geological uncertainty within the context of closed-loop reservoir management. (6) To ensure the research results will lead to practical public tools for independent oil companies, as part of the project we built a graphical user interface for the reservoir simulator and history matching software using Visual Basic.

  1. Integrated seal for high-temperature electrochemical device

    DOE Patents [OSTI]

    Tucker, Michael C; Jacobson, Craig P

    2013-07-16T23:59:59.000Z

    The present invention provides electrochemical device structures having integrated seals, and methods of fabricating them. According to various embodiments the structures include a thin, supported electrolyte film with the electrolyte sealed to the support. The perimeter of the support is self-sealed during fabrication. The perimeter can then be independently sealed to a manifold or other device, e.g., via an external seal. According to various embodiments, the external seal does not contact the electrolyte, thereby eliminating the restrictions on the sealing method and materials imposed by sealing against the electrolyte.

  2. HIGH INTEGRITY MAGNESIUM AUTOMOTIVE COMPONENTS (HIMAC) | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGrid Integration0-1HAWAI'I CLEANDepartmentDOE

  3. INTEGRATION OF HIGH TEMPERATURE GAS REACTORS WITH IN SITU OIL SHALE RETORTING

    SciTech Connect (OSTI)

    Eric P. Robertson; Michael G. McKellar; Lee O. Nelson

    2011-05-01T23:59:59.000Z

    This paper evaluates the integration of a high-temperature gas-cooled reactor (HTGR) to an in situ oil shale retort operation producing 7950 m3/D (50,000 bbl/day). The large amount of heat required to pyrolyze the oil shale and produce oil would typically be provided by combustion of fossil fuels, but can also be delivered by an HTGR. Two cases were considered: a base case which includes no nuclear integration, and an HTGR-integrated case.

  4. Integration of High-Temperature Gas-Cooled Reactors into Industrial Process Applications

    SciTech Connect (OSTI)

    Lee Nelson

    2011-09-01T23:59:59.000Z

    This report is a summary of analyses performed by the NGNP project to determine whether it is technically and economically feasible to integrate high temperature gas cooled reactor (HTGR) technology into industrial processes. To avoid an overly optimistic environmental and economic baseline for comparing nuclear integrated and conventional processes, a conservative approach was used for the assumptions and calculations.

  5. High resolution reanalysis of wind speeds over the British Isles for wind energy integration 

    E-Print Network [OSTI]

    Hawkins, Samuel Lennon

    2012-11-29T23:59:59.000Z

    The UK has highly ambitious targets for wind development, particularly offshore, where over 30GW of capacity is proposed for development. Integrating such a large amount of variable generation presents enormous challenges. ...

  6. High-speed silicon electro-optic modulator for electronic photonic integrated circuits

    E-Print Network [OSTI]

    Gan, Fuwan

    2007-01-01T23:59:59.000Z

    The development of future electronic-photonic integrated circuits (EPIC) based on silicon technology critically depends on the availability of CMOS-compatible high-speed modulators that enable the interaction of electronic ...

  7. Current mode integrators and their applications in low-voltage high frequency CMOS signal processing

    E-Print Network [OSTI]

    1993-01-01T23:59:59.000Z

    Low voltage CMOS fully differential integrators for high frequency continuous-time filters using current-mode techniques are presented.. Current mode techniques are employed to avoid the use of the floating differential pair, in order to achieve...

  8. Optimization of Integrated Transistors for Very High Frequency DC-DC Converters

    E-Print Network [OSTI]

    Sagneri, Anthony D.

    This paper presents a method to optimize integrated lateral double-diffused MOSFET transistors for use in very high frequency (VHF, 30-300 MHz) dc-dc converters. A transistor model valid at VHF switching frequencies is ...

  9. Correlated tuning of high-frequency integrated continuous-time filters 

    E-Print Network [OSTI]

    Brooks, Todd Lee

    1992-01-01T23:59:59.000Z

    CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis TODD LEE BROOKS Submitted to the Once of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1992 Major Subject: Electrical Engineering CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis by TODD LEE BROOKS Approved as to style and content by: Ran 11 L. Geiger (Co-Chair of Committee) William G...

  10. Correlated tuning of high-frequency integrated continuous-time filters

    E-Print Network [OSTI]

    Brooks, Todd Lee

    1992-01-01T23:59:59.000Z

    CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis TODD LEE BROOKS Submitted to the Once of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1992 Major Subject: Electrical Engineering CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis by TODD LEE BROOKS Approved as to style and content by: Ran 11 L. Geiger (Co-Chair of Committee) William G...

  11. High Power Density Integrated Traction Machine Drive | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEN TOTechnologyHighLouisianaDepartment of HIGH1

  12. High Power Density Integrated Traction Machine Drive | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEN TOTechnologyHighLouisianaDepartment of HIGH10

  13. Princeton Power Systems (TRL 5 6 Component)- Marine High-Voltage Power Conditioning and Transmission System with Integrated Energy Storage

    Broader source: Energy.gov [DOE]

    Princeton Power Systems (TRL 5 6 Component) - Marine High-Voltage Power Conditioning and Transmission System with Integrated Energy Storage

  14. Unconventional Architectures for High-Throughput Sciences

    SciTech Connect (OSTI)

    Nieplocha, Jarek; Marquez, Andres; Petrini, Fabrizio; Chavarría-Miranda, Daniel

    2007-06-15T23:59:59.000Z

    Science laboratories and sophisticated simulations are producing data of increasing volumes and complexities, and that’s posing significant challenges to current data infrastructures as terabytes to petabytes of data must be processed and analyzed. Traditional computing platforms, originally designed to support model-driven applications, are unable to meet the demands of the data-intensive scientific applications. Pacific Northwest National Laboratory (PNNL) research goes beyond “traditional supercomputing” applications to address emerging problems that need scalable, real-time solutions. The outcome is new unconventional architectures for data-intensive applications specifically designed to process the deluge of scientific data, including FPGAs, multithreaded architectures and IBM's Cell.

  15. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, Solomon (Hinsdale, IL); Bozen, Ralph M. (Hattiesburg, MS)

    1992-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  16. High-Throughput and Combinatorial Screening

    E-Print Network [OSTI]

    , for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL Hydride + H2 Complex Hydride Boride + Binary Hydride + H2 Metal Borohydride We can test six samples per vessel design complete ­ 15 sample hotplates, 3 gas detectors Achieve sample temperatures of 1200 K and H

  17. A High-Throughput Macromolecule Characterization System

    E-Print Network [OSTI]

    Kim, Jae Hyun

    2013-08-31T23:59:59.000Z

    stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method...

  18. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, S.; Bozen, R.M.

    1992-12-22T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  19. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2012-09-11T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  20. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2014-10-14T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  1. DOE Workshop HIGH THROUGHPUT/COMBINATORIAL SCREENING

    E-Print Network [OSTI]

    Properties Characterization · Optical/Electronic Materials · Vapor Phase Thin-Film Synthesis · Solution Phase Library Synthesis · HT Materials Characterization · HT Device Fabrication and Performance Evaluation #12/displays, materials for digital radiography, inorganic and organic OLEDs, TCOs Electronics Applications semiconductors

  2. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledge of

  3. High Efficiency Microturbine with Integral Heat Recovery - Presentation by

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEN TOTechnologyHigh Efficiency Low

  4. High-Level Liquid Waste Tank Integrity Workshop - 2008

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM Flash2011-12Approved on 24 July 2008 1 Office ofHigh

  5. On Achieving Optimal Throughput with Network Coding

    E-Print Network [OSTI]

    Li, Baochun

    to the problem of optimizing end-to- end throughput in undirected data networks. We first illustrate the powerOn Achieving Optimal Throughput with Network Coding Zongpeng Li, Baochun Li, Dan Jiang, Lap Chi Lau Abstract-- With the constraints of network topologies and link capacities, achieving the optimal end

  6. Warm-white light-emitting diodes integrated with colloidal quantum dots for high luminous

    E-Print Network [OSTI]

    Demir, Hilmi Volkan

    Warm-white light-emitting diodes integrated with colloidal quantum dots for high luminous efficacy NQD-LED design with both high luminous efficacy of optical radiation and CRI is presented to have luminous efficacy of optical ra- diation (LER), which is challenging using conventional phosphors

  7. High Efficancy Integrated Under-Cabinet Phosphorescent OLED

    SciTech Connect (OSTI)

    Michael Hack

    2001-10-31T23:59:59.000Z

    In this two year program Universal Display Corporation (UDC) together with the University of Michigan, Teknokon, developed and delivered an energy efficient phosphorescent OLED under cabinet illumination system. Specifically the UDC team goal was in 2011 to deliver five (5) Beta level OLED under cabinet lighting fixtures each consisting of five 6-inch x 6-inch OLED lighting panels, delivering over 420 lumens, at an overall system efficacy of >60 lm/W, a CRI of >85, and a projected lifetime to 70% of initial luminance to exceed 20,000 hours. During the course of this program, the Team pursued the commercialization of these OLED based under cabinet lighting fixtures, to enable the launch of commercial OLED lighting products. The UDC team was ideally suited to develop these novel and efficient solid state lighting fixtures, having both the technical experience and commercial distribution mechanisms to leverage work performed under this contract. UDC's business strategy is to non-exclusively license its PHOLED technology to lighting manufacturers, and also supply them with our proprietary PHOLED materials. UDC is currently working with several licensees who are manufacturing OLED lighting panels using our technology. During this 2 year program, we further developed our high efficiency white Phosphorescent OLEDs from the first milestone, achieving a 80 lm/W single pixel to the final milestone, achieving an under-cabinet PHOLED lighting system that operates at 56 lm/W at 420 lumens. Each luminaire was comprised of ten 15cm x 7.5cm lighting modules mounted in outcoupling enhancement lenses and a control module. The lamps modules are connected together using either plugs or wires with plugs on each end, allowing for unlimited configurations. The lamps are driven by an OLED driver mounted in an enclosure which includes the AC plug. As a result of advancements gained under this program, the path to move OLED lighting panels from development into manufacturing has been further realized. We have found that under-cabinet lighting is an ideal first entry product opportunity to launch OLED lighting for residential applications. From the studies that we have performed, our PHOLED under-cabinet lighting system performance is very similar to many of the current commercially available LED under-cabinet luminaires. We also found that the projected cost of PHOLED luminaire should be comparable to the LED luminaire by 2015. With the additional benefits of PHOLED lighting, no glare, better uniformity and low operating temperature, it can be easily seen how the PHOLED under-cabinet luminaire could be preferred over the LED competition. Although the metrics we set for this program were extremely aggressive, the performance we achieved and reported, represents a very significant advancement in the OLED lighting industry.

  8. Initial Operation of the High Temperature Electrolysis Integrated Laboratory Scale Experiment at INL

    SciTech Connect (OSTI)

    C. M. Stoots; J. E. O'Brien; K. G. Condie; J. S. Herring; J. J. Hartvigsen

    2008-06-01T23:59:59.000Z

    An integrated laboratory scale, 15 kW high-temperature electrolysis facility has been developed at the Idaho National Laboratory under the U.S. Department of Energy Nuclear Hydrogen Initiative. Initial operation of this facility resulted in over 400 hours of operation with an average hydrogen production rate of approximately 0.9 Nm3/hr. The integrated laboratory scale facility is designed to address larger-scale issues such as thermal management (feed-stock heating, high-temperature gas handling), multiple-stack hot-zone design, multiple-stack electrical configurations, and other “integral” issues. This paper documents the initial operation of the ILS, with experimental details about heat-up, initial stack performance, as well as long-term operation and stack degradation.

  9. Fabrication and characterization of high-speed integrated electro-optic lens and scanner devices

    E-Print Network [OSTI]

    Gopalan, Venkatraman

    of a laser beam with high speed is useful for many applications including optical data storage, laser elements for focusing and scanning, thus requiring multi-step manufacturing processes and sometimes difficult alignment procedures. Integration ofthese components into a single manufacturing step promises

  10. Materials and Process Design for High-Temperature Carburizing: Integrating Processing and Performance

    SciTech Connect (OSTI)

    D. Apelian

    2007-07-23T23:59:59.000Z

    The objective of the project is to develop an integrated process for fast, high-temperature carburizing. The new process results in an order of magnitude reduction in cycle time compared to conventional carburizing and represents significant energy savings in addition to a corresponding reduction of scrap associated with distortion free carburizing steels.

  11. Integrated High-Quality Factor Optical Resonators in Diamond B. J. M. Hausmann,,

    E-Print Network [OSTI]

    Loncar, Marko

    -performance devices places stringent requirements on the diamond film quality. For example, polycrystalline diamond associated with polycrystalline and ion-sliced single crystal diamond films. For example, low-loss opticalIntegrated High-Quality Factor Optical Resonators in Diamond B. J. M. Hausmann,, I. B. Bulu,, P. B

  12. Structural integrity and potential failure modes of hanford high-level waste tanks

    SciTech Connect (OSTI)

    Han, F.C.

    1996-09-30T23:59:59.000Z

    Structural Integrity of the Hanford High-Level Waste Tanks were evaluated based on the existing Design and Analysis Documents. All tank structures were found adequate for the normal operating and seismic loads. Potential failure modes of the tanks were assessed by engineering interpretation and extrapolation of the existing engineering documents.

  13. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems (Extended Version)

    E-Print Network [OSTI]

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems (Extended Version security, and yet incurs minimal end-to-end communication latency. Keywords: SCADA network security, bump links between devices in legacy Supervisory Con- trol And Data Acquisition (SCADA) systems, on which

  14. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems

    E-Print Network [OSTI]

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems Patrick P. Tsang in Supervisory Control And Data Acquisition (SCADA) systems. Previous BITW solutions fail to provide minimal end-to-end communication latency. A microcontroller prototype of our solution is under development

  15. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems

    E-Print Network [OSTI]

    Smith, Sean W.

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems Patrick P. Tsang-to-end communication latency. 1 Introduction 1.1 SCADA Systems Supervisory Control And Data Acquisition (SCADA) systems Supervisory Control And Data Acquisition (SCADA) systems, on which the proper operations of critical

  16. Heat generation from electronics increases with the advent of high-density integrated circuit technology. To

    E-Print Network [OSTI]

    Boyer, Edmond

    circuit technology. To come up with the heat generation, microscale cooling has been thought as a promising technology. Prediction of heat transfer rate is crucial in design of microscale cooling device1 Abstract Heat generation from electronics increases with the advent of high-density integrated

  17. High-Level Information An Approach for Integrating Front-End and Back-End Compilers

    E-Print Network [OSTI]

    Li, Zhiyuan

    High-Level Information ­ An Approach for Integrating Front-End and Back-End Compilers Sangyeun Cho-end and back-end compilers by passing front-end information to the back-end compiler. Importing this information into an existing back- end leverages the state-of-the-art analysis and transforma- tion

  18. Operation and Control of Distribution Systems with high level integration of Renewable Generation units

    E-Print Network [OSTI]

    Bak-Jensen, Birgitte

    models Probabilistic methodologies are being applied to power system analysis since 70' [9] becauseOperation and Control of Distribution Systems with high level integration of Renewable Generation. Diagonal 649 Pavelló A, 08028 Barcelona, Spain Summary Traditional power systems have a hierarchical

  19. Recent advances in III-V on Si integration for high-efficiency,

    E-Print Network [OSTI]

    Firestone, Jeremy

    Recent advances in III-V on Si integration for high-efficiency, low cost MJ cells Minjoo Larry Lee for concentrator photovoltaics · Metamorphic mid-infrared (2-3 µm) materials and devices(w/ D.Wasserman, UIUC · Conclusions 4 300 mm Si Low-cost, high- efficiency MJ cells on 300 mm Si 50 mm GaP 150 mm GaAs #12;Challenge

  20. Integrating High Penetrations of PV into Southern California: Year 2 Project Update; Preprint

    SciTech Connect (OSTI)

    Mather, B.; Neal, R.

    2012-08-01T23:59:59.000Z

    Southern California Edison (SCE) is well into a five-year project to install a total of 500 MW of distributed photovoltaic (PV) energy within its utility service territory. Typical installations to date are 1-3 MW peak rooftop PV systems that interconnect to medium-voltage urban distribution circuits or larger (5 MW peak) ground-mounted systems that connect to medium-voltage rural distribution circuits. Some of the PV system interconnections have resulted in distribution circuits that have a significant amount of PV generation compared to customer load, resulting in high-penetration PV integration scenarios. The National Renewable Energy Laboratory (NREL) and SCE have assembled a team of distribution modeling, resource assessment, and PV inverter technology experts in order to investigate a few of the high-penetration PV distribution circuits. Currently, the distribution circuits being studied include an urban circuit with a PV penetration of approximately 46% and a rural circuit with a PV penetration of approximately 60%. In both cases, power flow on the circuit reverses direction, compared to traditional circuit operation, during periods of high PV power production and low circuit loading. Research efforts during year two of the five-year project were focused on modeling the distribution system level impacts of high-penetration PV integrations, the development and installation of distribution circuit data acquisition equipment appropriate for quantifying the impacts of high-penetration PV integrations, and investigating high-penetration PV impact mitigation strategies. This paper outlines these research efforts and discusses the following activities in more detail: the development of a quasi-static time-series test feeder for evaluating high-penetration PV integration modeling tools; the advanced inverter functions being investigated for deployment in the project's field demonstration and a power hardware-in-loop test of a 500-kW PV inverter implementing a limited set of advanced inverter functions.

  1. An Integrated Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High-Frequency Drive

    E-Print Network [OSTI]

    Sanders, Seth

    An Integrated Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High-Frequency Drive Copyright 2003 by Perry I-Pei Tsao #12;1 Abstract An Integrated Flywheel Energy Storage System with a Homopolar

  2. Flux-weakening operation of open-end winding drive integrating a cost effective high-power charger

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Flux-weakening operation of open-end winding drive integrating a cost effective high-power charger-end winding drive integrating a cost effective high-power charger Page 1 of 26 IET Review Copy Only IET Inverter (VSI) and an open-end winding Interior Permanent Magnet Synchronous Machine (IPMSM) designed

  3. Stable Throughput in a Cognitive Wireless Network

    E-Print Network [OSTI]

    Fanous, Anthony

    2012-01-01T23:59:59.000Z

    We study, from a network layer perspective, the effect of an Ad-Hoc secondary network with N nodes randomly accessing the spectrum licensed to a primary node during the idle slots of the primary user. If the sensing is perfect, then the secondary nodes do not interfere with the primary node and hence do not affect its stable throughput. In case of imperfect sensing, it is shown that if the primary user's arrival rate is less than some calculated finite value, cognitive nodes can employ any transmission power or probabilities without affecting the primary user's stability; otherwise, the secondary nodes should control their transmission parameters to reduce the interference on the primary. It is also shown that in contrast with the primary's maximum stable throughput which strictly decreases with increased sensing errors, the throughput of the secondary nodes might increase with sensing errors as more transmission opportunities become available to them. Finally, we explore the use of the secondary nodes as rel...

  4. High Efficiency Optical MEMS by the Integration of Photonic Lattices with Surface MEMS

    SciTech Connect (OSTI)

    FLEMING, JAMES G.; LIN, SHAWN-YU; MANI, SEETHAMBAL S.; RODGERS, M. STEVEN; DAGEL, DARYL J.

    2002-11-01T23:59:59.000Z

    This report outlines our work on the integration of high efficiency photonic lattice structures with MEMS (MicroElectroMechanical Systems). The simplest of these structures were based on 1-D mirror structures. These were integrated into a variety of devices, movable mirrors, switchable cavities and finally into Bragg fiber structures which enable the control of light in at least 2 dimensions. Of these devices, the most complex were the Bragg fibers. Bragg fibers consist of hollow tubes in which light is guided in a low index media (air) and confined by surrounding Bragg mirror stacks. In this work, structures with internal diameters from 5 to 30 microns have been fabricated and much larger structures should also be possible. We have demonstrated the fabrication of these structures with short wavelength band edges ranging from 400 to 1600nm. There may be potential applications for such structures in the fields of integrated optics and BioMEMS. We have also looked at the possibility of waveguiding in 3 dimensions by integrating defects into 3-dimensional photonic lattice structures. Eventually it may be possible to tune such structures by mechanically modulating the defects.

  5. Throughput Analysis of Wireless Ad-Hoc Cognitive Radio Networks 

    E-Print Network [OSTI]

    Banaei, Armin

    2014-04-25T23:59:59.000Z

    In this dissertation we consider the throughput performance of cognitive radio networks and derive the optimal sensing and access schemes for secondary users that maximizes their sum-throughput while guaranteeing certain ...

  6. Maximum Throughput Power Control in CDMA Wireless Networks

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Maximum Throughput Power Control in CDMA Wireless Networks Anastasios Giannoulis Department introduce cross­layer, distributed power control algorithms that guarantee maximum possible data throughput performing dynamic routing and scheduling together with power control. The cross­layer interaction consists

  7. An overlay architecture for throughput optimal multipath routing

    E-Print Network [OSTI]

    Jones, Nathaniel M.

    Legacy networks are often designed to operate with simple single-path routing, like shortest-path, which is known to be throughput suboptimal. On the other hand, previously proposed throughput optimal policies (i.e., ...

  8. Throughput Analysis of Wireless Ad-Hoc Cognitive Radio Networks

    E-Print Network [OSTI]

    Banaei, Armin

    2014-04-25T23:59:59.000Z

    In this dissertation we consider the throughput performance of cognitive radio networks and derive the optimal sensing and access schemes for secondary users that maximizes their sum-throughput while guaranteeing certain quality of service...

  9. A pedagogical introduction to quantum integrability, with a view towards theoretical high-energy physics

    E-Print Network [OSTI]

    J. Lamers

    2015-01-27T23:59:59.000Z

    These are lecture notes of an introduction to quantum integrability given at the Tenth Modave Summer School in Mathematical Physics, 2014, aimed at PhD candidates and junior researchers in theoretical physics. We introduce spin chains and discuss the coordinate Bethe Ansatz (CBA) for a representative example: the Heisenberg XXZ model. The focus lies on the structure of the CBA and on its main results, deferring a detailed treatment of the CBA for the general $M$-particle sector of the XXZ model to an appendix. Subsequently the transfer-matrix method is discussed for the six-vertex model, uncovering a relation between that model and the XXZ spin chain. Equipped with this background the quantum inverse-scattering method (QISM) and algebraic Bethe Ansatz (ABA) are treated. We emphasize the use of graphical notation for algebraic quantities as well as computations. Finally we turn to quantum integrability in the context of theoretical high-energy physics. We discuss factorized scattering in two-dimensional QFT, and conclude with a qualitative introduction to one current research topic relating quantum integrability to theoretical high-energy physics: the Bethe/gauge correspondence.

  10. Models for the Configuration and Integrity of Partially Oxidized Fuel Rod Cladding at High Temperatures

    SciTech Connect (OSTI)

    Siefken, L.J.

    1999-01-01T23:59:59.000Z

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. These models are expected to improve the calculations of several important aspects of fuel rod behavior. First, an improved mapping was established from a compilation of PIE results from severe fuel damage tests of the configuration of melted metallic cladding that is retained by an oxide layer. The improved mapping accounts for the relocation of melted cladding in the circumferential direction. Then, rules based on PIE results were established for calculating the effect of cladding that has relocated from above on the oxidation and integrity of the lower intact cladding upon which it solidifies. Next, three different methods were identified for calculating the extent of dissolution of the oxidic part of the cladding due to its contact with the metallic part. The extent of dissolution effects the stress and thus the integrity of the oxidic part of the cladding. Then, an empirical equation was presented for calculating the stress in the oxidic part of the cladding and evaluating its integrity based on this calculated stress. This empirical equation replaces the current criterion for loss of integrity which is based on temperature and extent of oxidation. Finally, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The implementation of these models is expected to eliminate the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material. This report is a revision and reissue of the report entitled, Improvements in Modeling of Cladding Oxidation and Meltdown.

  11. PROCESS CHANGES TO DWPF TO INCREASE THROUGHPUT AND INCORPORATE SALT STREAMS

    SciTech Connect (OSTI)

    Herman, C; David Peeler, D; Tommy Edwards, T; Michael Stone, M; Michael02 Smith, M

    2007-06-13T23:59:59.000Z

    The Defense Waste Processing Facility (DWPF) has been vitrifying High Level Waste sludge since 1996. Sludge batch 1a, 1b, 2, and 3 have been successfully stabilized. In the last several years, the Savannah River National Laboratory (SRNL) has worked with DWPF to implement process and compositional changes to improve throughput. These changes allowed significant increases in waste throughput for processing of sludge batch 3 and will be necessary to maintain reasonable throughput for Sludge Batch 4 (SB4). SB4 processing was initiated in June 2007 and will be the first significantly HM-type sludge batch processed. This sludge is high in aluminum and other components troublesome to DWPF processing. In addition, coupled processing is scheduled to start in the next fiscal year, which will also impact throughput. Coupled processing will begin with the incorporation of waste streams from the Actinide Removal Process and the Modular Caustic Side Solvent Extraction Unit and will eventually transition to the feed from the larger scale Salt Waste Processing Facility. A discussion of the programs to improve throughput and implement salt processing will be provided.

  12. Integrated High Temperature Coal-to-Hydrogen System with CO2 Separation

    SciTech Connect (OSTI)

    James A. Ruud; Anthony Ku; Vidya Ramaswamy; Wei Wei; Patrick Willson

    2007-05-31T23:59:59.000Z

    A significant barrier to the commercialization of coal-to-hydrogen technologies is high capital cost. The purity requirements for H{sub 2} fuels are generally met by using a series of unit clean-up operations for residual CO removal, sulfur removal, CO{sub 2} removal and final gas polishing to achieve pure H{sub 2}. A substantial reduction in cost can be attained by reducing the number of process operations for H{sub 2} cleanup, and process efficiency can be increased by conducting syngas cleanup at higher temperatures. The objective of this program was to develop the scientific basis for a single high-temperature syngas-cleanup module to produce a pure stream of H{sub 2} from a coal-based system. The approach was to evaluate the feasibility of a 'one box' process that combines a shift reactor with a high-temperature CO{sub 2}-selective membrane to convert CO to CO{sub 2}, remove sulfur compounds, and remove CO{sub 2} in a simple, compact, fully integrated system. A system-level design was produced for a shift reactor that incorporates a high-temperature membrane. The membrane performance targets were determined. System level benefits were evaluated for a coal-to-hydrogen system that would incorporate membranes with properties that would meet the performance targets. The scientific basis for high temperature CO{sub 2}-selective membranes was evaluated by developing and validating a model for high temperature surface flow membranes. Synthesis approaches were pursued for producing membranes that integrated control of pore size with materials adsorption properties. Room temperature reverse-selectivity for CO{sub 2} was observed and performance at higher temperatures was evaluated. Implications for future membrane development are discussed.

  13. Towards Fully Integrated High Temperature Wireless Sensors Using GaN-based HEMT Devices

    SciTech Connect (OSTI)

    Kuruganti, Phani Teja [ORNL; Islam, Syed K [ORNL; Huque, Mohammad A [ORNL

    2008-01-01T23:59:59.000Z

    Wireless sensors which are capable of working at extreme environments can significantly improve the efficiency and performance of industrial processes by facilitating better control systems. GaN, a widely researched wide bandgap material, has the potential to be used both as a sensing material and to fabricate control electronics, making it a prime candidate for high temperature integrated wireless sensor fabrication. In this paper we are presenting an experimental study on AlGaN/GaN HEMT's performance at higher temperature (up to 300 C). From test results, DC and microwave parameters at different temperatures were extracted.

  14. Integrating INIS into a high energy physics information environment thoughts from CERN

    E-Print Network [OSTI]

    Yeomans, Joanne; Baudic, Romain; Picchioli, Ingrid; International Conference on Nuclear Knowledge Management : Strategies, Information Management and Human Resource Development. Special Session : The Role of INIS in Knowledge Preservation

    2004-01-01T23:59:59.000Z

    Information searchers from the high energy physics community expect an integrated information environment. The CERN Library offers its print and electronic collections through a combined Web interface and maintains the database by semi-automated processes to upload bibliographic and full-text records. Suggestions are offered by which INIS could develop its own Web interface and better match HEP users’ expectations. These include implementing full-text linking, increasing currency, expanding search and display functions and developing the richness of the data. Links with the National Nuclear Data Center and Crossref could also increase its visibility.

  15. High-speed graphene interconnects monolithically integrated with CMOS ring oscillators operating at 1.3GHz

    E-Print Network [OSTI]

    Chen, Xiangyu

    We have successfully experimentally integrated graphene interconnects with commercial 0.25 Âżm technology CMOS ring oscillator circuit using conventional fabrication techniques, and demonstrated high speed on-chip graphene ...

  16. Towards High-Fidelity Quantum Computation and Simulation on a Programmable Photonic Integrated Circuit

    E-Print Network [OSTI]

    Jacob Mower; Nicholas C. Harris; Gregory R. Steinbrecher; Yoav Lahini; Dirk Englund

    2014-12-16T23:59:59.000Z

    We propose and analyze the design of a programmable photonic integrated circuit for high-fidelity quantum computation and simulation. We demonstrate that the reconfigurability of our design allows us to overcome two major impediments to quantum optics on a chip: it removes the need for a full fabrication cycle for each experiment and allows for compensation of fabrication errors using numerical optimization techniques. Under a pessimistic fabrication model for the silicon-on-insulator process, we demonstrate a dramatic fidelity improvement for the linear optics CNOT and CPHASE gates and, showing the scalability of this approach, the iterative phase estimation algorithm built from individually optimized gates. We also propose and simulate a novel experiment that the programmability of our system would enable: a statistically robust study of the evolution of entangled photons in disordered quantum walks. Overall, our results suggest that existing fabrication processes are sufficient to build a quantum photonic processor capable of high fidelity operation.

  17. High temperature energy conversion for the Integrated Solar Upper Stage (ISUS)

    SciTech Connect (OSTI)

    Ramalingam, M.L. [UES, Inc., Dayton, OH (United States); Lamp, T.R. [Wright Lab., Wright Patterson AFB, OH (United States); Jacox, M.; Kennedy, F. [Phillips Lab., Kirtland AFB, NM (United States)

    1996-12-31T23:59:59.000Z

    Preliminary studies were conducted to assess the benefits of the Integrated Solar Upper Stage (ISUS) concept and key components including high temperature thermionic converters, have been tested and evaluated. Advanced radiatively coupled heat pipe cooled thermionic converters with rhenium and tungsten emitters were characterized individually for integration in a modular power unit. The converter with the tungsten emitter was performance mapped in the temperature range of 1,750 K to 2,400 K in order to conform to the ISUS requirements. Higher off-design temperatures yielded power densities as high as 12 watts/sq. cm. in the cesium pressure range of 4 to 9 torr. The converter with the rhenium emitter was tested in the temperature range of 1,575 K to 1,950 K and produced 10.5 watts/sq. cm. at the highest temperature. Dynamic switching characteristics were also measured to evaluate the possibility of interfacing a pulse width modulated (PWM) power regulator directly to a thermionic source.

  18. High energy emission and polarisation limits for the INTEGRAL burst GRB 061122

    E-Print Network [OSTI]

    McGlynn, S; McBreen, B; Hanlon, L; McBreen, S; Clark, D J; Dean, A J; Martin-Carrillo, A; O'Connor, R

    2009-01-01T23:59:59.000Z

    (Abridged) GRB 061122 is one of the brightest GRBs detected within INTEGRAL's field of view to date. The two gamma-ray detectors on INTEGRAL were used to investigate the spectral characteristics of GRB 061122. A search for linear polarisation in the prompt emission was carried out using the SPI multiple event data in the energy range 100 keV-1 MeV. The prompt spectrum was best fit by a combination of a blackbody and a power--law model (the quasithermal model), with evidence for high energy emission continuing above 8 MeV. A pseudo-redshift value of pz = 0.95 +/- 0.18 was determined using the spectral fit parameters. The isotropic energy at this pseudo-redshift is 8.5 x 10^{52} erg. The jet opening angle was estimated to be smaller than 2.8 deg or larger than 11.9 deg from the X-ray lightcurve. An upper limit of 60% polarisation was determined for the prompt emission of GRB 061122, using the multiple event data. The high energy emission observed in the spectrum may be due to the reverse shock interacting with ...

  19. New hydrocracking catalysts increase throughput, run length

    SciTech Connect (OSTI)

    Huizinga, T. [Shell Internationale Petroleum Mij., The Hague (Netherlands); Theunissen, J.M.H. [Rayong Refinery Co. Ltd., Rayong (Thailand); Minderhoud, H.; Veen, R. van [Koninklijke/Shell-Lab., Amsterdam (Netherlands)

    1995-06-26T23:59:59.000Z

    An improved, second-stage hydrocracking catalyst has been developed by combining stabilized Y zeolites with amorphous silica alumina cracking components. A commercial application of this catalyst, along with a new, first-stage zeolitic hydrocracking catalyst, resulted in increased unit throughput and cycle length. The paper discusses the hydrocracking process, first-stage catalysts, second-stage catalysts, hydrogenation process, commercial results, and product properties.

  20. Trapped Capacity: Scheduling under a Power Cap to Maximize Machine-Room Throughput

    E-Print Network [OSTI]

    Pakin, Scott

    in the machine room and thereby increase system throughput. Our goal is not to reduce energy or power consumption power and energy in machine rooms. In practice the power for machine rooms is well over-provisioned, specified by high energy LINPACK runs or nameplate power estimates. This results in a considerable amount

  1. Design of an Integrated Laboratory Scale Test for Hydrogen Production via High Temperature Electrolysis

    SciTech Connect (OSTI)

    G.K. Housley; K.G. Condie; J.E. O'Brien; C. M. Stoots

    2007-06-01T23:59:59.000Z

    The Idaho National Laboratory (INL) is researching the feasibility of high-temperature steam electrolysis for high-efficiency carbon-free hydrogen production using nuclear energy. Typical temperatures for high-temperature electrolysis (HTE) are between 800ş-900şC, consistent with anticipated coolant outlet temperatures of advanced high-temperature nuclear reactors. An Integrated Laboratory Scale (ILS) test is underway to study issues such as thermal management, multiple-stack electrical configuration, pre-heating of process gases, and heat recuperation that will be crucial in any large-scale implementation of HTE. The current ILS design includes three electrolysis modules in a single hot zone. Of special design significance is preheating of the inlet streams by superheaters to 830°C before entering the hot zone. The ILS system is assembled on a 10’ x 16’ skid that includes electronics, power supplies, air compressor, pumps, superheaters, , hot zone, condensers, and dew-point sensor vessels. The ILS support system consists of three independent, parallel supplies of electrical power, sweep gas streams, and feedstock gas mixtures of hydrogen and steam to the electrolysis modules. Each electrolysis module has its own support and instrumentation system, allowing for independent testing under different operating conditions. The hot zone is an insulated enclosure utilizing electrical heating panels to maintain operating conditions. The target hydrogen production rate for the ILS is 5000 Nl/hr.

  2. A pedagogical introduction to quantum integrability, with a view towards theoretical high-energy physics

    E-Print Network [OSTI]

    Lamers, J

    2015-01-01T23:59:59.000Z

    These are lecture notes of an introduction to quantum integrability given at the Tenth Modave Summer School in Mathematical Physics, 2014, aimed at PhD candidates and junior researchers in theoretical physics. We introduce spin chains and discuss the coordinate Bethe Ansatz (CBA) for a representative example: the Heisenberg XXZ model. The focus lies on the structure of the CBA and on its main results, deferring a detailed treatment of the CBA for the general $M$-particle sector of the XXZ model to an appendix. Subsequently the transfer-matrix method is discussed for the six-vertex model, uncovering a relation between that model and the XXZ spin chain. Equipped with this background the quantum inverse-scattering method (QISM) and algebraic Bethe Ansatz (ABA) are treated. We emphasize the use of graphical notation for algebraic quantities as well as computations. Finally we turn to quantum integrability in the context of theoretical high-energy physics. We discuss factorized scattering in two-dimensional QFT, a...

  3. High Aspect Pattern Formation by Integration of Micro Inkjetting and Electroless Plating

    E-Print Network [OSTI]

    Gian, P W; Liang, Y N; Lok, B K; Lu, C W; Ooi, B L

    2008-01-01T23:59:59.000Z

    This paper reports on formation of high aspect micro patterns on low temperature co-fired ceramic (LTCC) substrates by integrating micro inkjetting with electroless plating. Micro inkjetting was realized by using an inkjetting printer that ejects ink droplets from a printhead. This printhead consists of a glass nozzle with a diameter of 50 micrometers and a piezoelectric transducer that is coated on the nozzle. The silver colloidal solution was inkjetted on a sintered CT800 ceramic substrate, followed by curing at 200 degrees C for 60 minutes. As a result, the silver trace with a thickness of 200 nm was obtained. The substrate, with the ejected silver thin film as the seed layer, was then immersed into a preinitiator solution to coat a layer of palladium for enhancing the deposition of nickel. Electroless nickel plating was successfully conducted at a rate of 0.39 micrometers /min, and the thickness of traces was plated up to 84 micrometers. This study demonstrates that the integration of inkjetting with plat...

  4. OASIS High-Resolution Integral Field Spectroscopy of the SAURON Ellipticals and Lenticulars

    E-Print Network [OSTI]

    McDermid, R; Cappellari, M; Kuntschner, H; Bacon, R; Bureau, M; Copin, Y; Davies, R L; Falcon-Barroso, J; Ferruit, P; Krajnovic, D; Peletier, R F; Shapiro, K; Wernli, F; De Zeeuw, P T

    2003-01-01T23:59:59.000Z

    We present a summary of high-spatial resolution follow-up observations of the elliptical (E) and lenticular (S0) galaxies in the SAURON survey using the OASIS integral field spectrograph. The OASIS observations explore the central 8x10" regions of these galaxies using a spatial sampling four times higher than SAURON, often revealing previously undiscovered features. Around 75% (31/48) of the SAURON E/S0s with central velocity dispersion >= 120 km/s were observed with OASIS, covering well the original SAURON representative sample. We present here an overview of this follow-up survey, and some preliminary results on individual objects, including a previously unreported counter-rotating core in NGC 4382; the decoupled stellar and gas velocity fields of NGC 2768; and the strong age gradient towards the centre of NGC 3489.

  5. OASIS High-Resolution Integral Field Spectroscopy of the SAURON Ellipticals and Lenticulars

    E-Print Network [OSTI]

    R. McDermid; E. Emsellem; M. Cappellari; H. Kuntschner; R. Bacon; M. Bureau; Y. Copin; R. L. Davies; J. Falcon-Barroso; P. Ferruit; D. Krajnovic; R. F. Peletier; K. Shapiro; F. Wernli; P. T. de Zeeuw

    2003-11-10T23:59:59.000Z

    We present a summary of high-spatial resolution follow-up observations of the elliptical (E) and lenticular (S0) galaxies in the SAURON survey using the OASIS integral field spectrograph. The OASIS observations explore the central 8x10" regions of these galaxies using a spatial sampling four times higher than SAURON, often revealing previously undiscovered features. Around 75% (31/48) of the SAURON E/S0s with central velocity dispersion >= 120 km/s were observed with OASIS, covering well the original SAURON representative sample. We present here an overview of this follow-up survey, and some preliminary results on individual objects, including a previously unreported counter-rotating core in NGC 4382; the decoupled stellar and gas velocity fields of NGC 2768; and the strong age gradient towards the centre of NGC 3489.

  6. Integrated-fin gasket for palm cubic-anvil high pressure apparatus

    SciTech Connect (OSTI)

    Cheng, J.-G. [Institute for Solid State Physics, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8581 (Japan); Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Matsubayashi, K.; Nagasaki, S.; Hisada, A.; Hirayama, T.; Uwatoko, Y. [Institute for Solid State Physics, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8581 (Japan); Hedo, M. [Faculty of Science, University of Ryukyus, Senbaru, Nishihara, Okinawa 903-0213 (Japan); Kagi, H. [Graduate School of Science, University of Tokyo, 7-3-1, Hongo Bunkyo-Ku, Tokyo 113-0033 (Japan)

    2014-09-15T23:59:59.000Z

    We described an integrated-fin gasket technique for the palm cubic-anvil apparatus specialized for the high-pressure and low-temperature measurements. By using such a gasket made from the semi-sintered MgO ceramics and the tungsten-carbide anvils of 2.5 mm square top, we successfully generate pressures over 16 GPa at both room and cryogenic temperatures down to 0.5 K. We observed a pressure self-increment for this specific configuration and further characterized the thermally induced pressure variation by monitoring the antiferromagnetic transition temperature of chromium up to 12 GPa. In addition to enlarge the pressure capacity, such a modified gasket also improves greatly the surviving rate of electrical leads hanging the sample inside a Teflon capsule filled with the liquid pressure-transmitting medium. These improvements should be attributed to the reduced extrusion of gasket materials during the initial compression.

  7. Efficiency Analysis of a High Frequency Buck Converter for On-Chip Integration with a Dual-VDD Microprocessor

    E-Print Network [OSTI]

    Friedman, Eby G.

    -VDD Microprocessor Volkan Kursun, Siva G. Narendra* , Vivek K. De* , and Eby G. Friedman Department of Electrical. Full integration of a high efficiency buck converter on the same die with a dual-VDD microprocessor of high performance microprocessors are the two primary reasons for implementing a dual-VDD microprocessor

  8. Optimum Reactor Outlet Temperatures for High Temperature Gas-Cooled Reactors Integrated with Industrial Processes

    SciTech Connect (OSTI)

    Lee O. Nelson

    2011-04-01T23:59:59.000Z

    This report summarizes the results of a temperature sensitivity study conducted to identify the optimum reactor operating temperatures for producing the heat and hydrogen required for industrial processes associated with the proposed new high temperature gas-cooled reactor. This study assumed that primary steam outputs of the reactor were delivered at 17 MPa and 540°C and the helium coolant was delivered at 7 MPa at 625–925°C. The secondary outputs of were electricity and hydrogen. For the power generation analysis, it was assumed that the power cycle efficiency was 66% of the maximum theoretical efficiency of the Carnot thermodynamic cycle. Hydrogen was generated via the hightemperature steam electrolysis or the steam methane reforming process. The study indicates that optimum or a range of reactor outlet temperatures could be identified to further refine the process evaluations that were developed for high temperature gas-cooled reactor-integrated production of synthetic transportation fuels, ammonia, and ammonia derivatives, oil from unconventional sources, and substitute natural gas from coal.

  9. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01T23:59:59.000Z

    Integration of Intermittent Renewable Technologies Yih-huei,W. ; Parsons, B National Renewable Energy Laboratory, August2020: Towards a Policy of Renewable and Distributed Energy

  10. Method and apparatus for maximizing throughput of indirectly heated rotary kilns

    DOE Patents [OSTI]

    Coates, Ralph L; Smoot, L. Douglas; Hatfield, Kent E

    2012-10-30T23:59:59.000Z

    An apparatus and method for achieving improved throughput capacity of indirectly heated rotary kilns used to produce pyrolysis products such as shale oils or coal oils that are susceptible to decomposition by high kiln wall temperatures is disclosed. High throughput is achieved by firing the kiln such that optimum wall temperatures are maintained beginning at the point where the materials enter the heating section of the kiln and extending to the point where the materials leave the heated section. Multiple high velocity burners are arranged such that combustion products directly impact on the area of the kiln wall covered internally by the solid material being heated. Firing rates for the burners are controlled to maintain optimum wall temperatures.

  11. Design Concept Evaluation Using System Throughput Model

    SciTech Connect (OSTI)

    G. Sequeira; W. M. Nutt Ph.D

    2004-05-28T23:59:59.000Z

    The U.S. Department of Energy (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is currently developing the technical bases to support the submittal of a license application for construction of a geologic repository at Yucca Mountain, Nevada to the U.S. Nuclear Regulatory Commission. The Office of Repository Development (ORD) is responsible for developing the design of the proposed repository surface facilities for the handling of spent nuclear fuel and high level nuclear waste. Preliminary design activities are underway to sufficiently develop the repository surface facilities design for inclusion in the license application. The design continues to evolve to meet mission needs and to satisfy both regulatory and program requirements. A system engineering approach is being used in the design process since the proposed repository facilities are dynamically linked by a series of sub-systems and complex operations. In addition, the proposed repository facility is a major system element of the overall waste management process being developed by the OCRWM. Such an approach includes iterative probabilistic dynamic simulation as an integral part of the design evolution process. A dynamic simulation tool helps to determine if: (1) the mission and design requirements are complete, robust, and well integrated; (2) the design solutions under development meet the design requirements and mission goals; (3) opportunities exist where the system can be improved and/or optimized; and (4) proposed changes to the mission, and design requirements have a positive or negative impact on overall system performance and if design changes may be necessary to satisfy these changes. This paper will discuss the type of simulation employed to model the waste handling operations. It will then discuss the process being used to develop the Yucca Mountain surface facilities model. The latest simulation model and the results of the simulation and how the data were used in the design evolution process will also be discussed. Since the use of dynamic simulation is iterative and integral to the design effort, future activities will also be summarized. The paper will close discussing lessons learned from applying dynamic simulation to designing complex systems, and will discuss what pitfalls to avoid and recommendations for developing flexibility in system model development.

  12. Technology support for initiation of high-throughput processing of thin-film CdTe PV modules. Phase 3 final technical report, 14 March 1997--1 April 1998

    SciTech Connect (OSTI)

    Powell, R.C.; Dorer, G.L.; Jayamaha, U.; Hanak, J.J. [Solar Cells, Inc., Toledo, OH (United States)

    1998-09-01T23:59:59.000Z

    Thin-film PV devices based on cadmium telluride have been identified as one of the candidates for high-performance, low-cost source of renewable electrical energy. Roadblocks to their becoming a part of the booming PV market growth have been a low rate of production and high manufacturing cost caused by several rate-limiting process steps. Solar Cells Inc. has focused on the development of manufacturing processes that will lead to high volume and low-cost manufacturing of solar cells and on increasing the performance of the present product. The process research in Phase 3 was concentrated on further refinement of a newly developed vapor transport deposition (VTD) process and its implementation into the manufacturing line. This development included subsystems for glass substrate transport, continuous feed of source materials, generation of source vapors, and uniform deposition of the semiconductor layers. As a result of this R and D effort, the VTD process has now achieved a status in which linear coating speeds in excess of 8 ft/min have been achieved for the semiconductor, equal to about two modules per minute, or 144 kW per 24 hour day. The process has been implemented in a production line, which is capable of round-the-clock continuous production of coated substrates 120 cm x 60 cm in size at a rate of 1 module every four minutes, equal to 18 kW/day. Currently the system cycle time is limited by the rate of glass introduction into the system and glass heating, but not by the rate of the semiconductor deposition. A new SCI record efficiency of 14.1% has been achieved for the cells.

  13. Integration of pentacene-based thin film transistors via photolithography for low and high voltage applications

    E-Print Network [OSTI]

    Smith, Melissa Alyson

    2012-01-01T23:59:59.000Z

    An organic thin film transistor (OTFT) technology platform has been developed for flexible integrated circuits applications. OTFT performance is tuned by engineering the dielectric constant of the gate insulator and the ...

  14. An Integrated Formal Approach for Developing High Quality Software for Safety-Critical Systems

    E-Print Network [OSTI]

    Ouyang, Meng

    This report presents the results of a study which devises an Integrated Formal Approach (IFA) for improving specifications of the designs of computer programs used in safety-critical systems. In this IFA, the formal ...

  15. Development of an Advanced Approach for Next Generation, High Resolution, Integrated Reservoir Characterization

    SciTech Connect (OSTI)

    Scott R. Reeves

    2003-08-01T23:59:59.000Z

    During this reporting period work on Task 4: Develop Integrated Engineering Model was completed, incorporating the results from Log Clustering. A series of Topical Reports were prepared on Seismic Data Processing, Rock Physics modeling, Log Clustering, and the Integrated Engineering Model. These Topical Reports have been submitted to the test site field operator for review before submission to NETL staff in Tulsa. Work continues on development of the Broadband Seismic Transform Function.

  16. NREL/SCE High-Penetration PV Integration Project: Report on Field Demonstration of Advanced Inverter Functionality in Fontana, CA

    SciTech Connect (OSTI)

    Mather, B.

    2014-08-01T23:59:59.000Z

    The National Renewable Energy Laboratory/Southern California Edison High-Penetration PV Integration Project is (1) researching the distribution system level impacts of high-penetration photovoltaic (PV) integration, (2) determining mitigation methods to reduce or eliminate those impacts, and (3) seeking to demonstrate these mitigation methods on actual high-penetration PV distribution circuits. This report describes a field demonstration completed during the fall of 2013 on the Fontana, California, study circuit, which includes a total of 4.5 MW of interconnected utility-scale rooftop PV systems. The demonstration included operating a 2-MW PV system at an off-unity power factor that had been determined during previously completed distribution system modeling and PV impact assessment analyses. Data on the distribution circuit and PV system operations were collected during the 2-week demonstration period. This demonstration reinforces the findings of previous laboratory testing that showed that utility-scale PV inverters are capable of operating at off-unity power factor to mitigate PV impacts; however, because of difficulties setting and retaining PV inverter power factor set points during the field demonstration, it was not possible to demonstrate the effectiveness of off-unity power factor operation to mitigate the voltage impacts of high-penetration PV integration. Lessons learned from this field demonstration are presented to inform future field demonstration efforts.

  17. Critical Causes of Degradation in Integrated Laboratory Scale Cells during High Temperature Electrolysis

    SciTech Connect (OSTI)

    M.S. Sohal; J.E. O'Brien; C.M. Stoots; J. J. Hartvigsen; D. Larsen; S. Elangovan; J.S. Herring; J.D. Carter; V.I. Sharma; B. Yildiz

    2009-05-01T23:59:59.000Z

    An ongoing project at Idaho National Laboratory involves generating hydrogen from steam using solid oxide electrolysis cells (SOEC). This report describes background information about SOECs, the Integrated Laboratory Scale (ILS) testing of solid-oxide electrolysis stacks, ILS performance degradation, and post-test examination of SOECs by various researchers. The ILS test was a 720- cell, three-module test comprised of 12 stacks of 60 cells each. A peak H2 production rate of 5.7 Nm3/hr was achieved. Initially, the module area-specific resistance ranged from 1.25 Ocm2 to just over 2 Ocm2. Total H2 production rate decreased from 5.7 Nm3/hr to a steady state value of 0.7 Nm3/hr. The decrease was primarily due to cell degradation. Post test examination by Ceramatec showed that the hydrogen electrode appeared to be in good condition. The oxygen evolution electrode does show delamination in operation and an apparent foreign layer deposited at the electrolyte interface. Post test examination by Argonne National Laboratory showed that the O2-electrode delaminated from the electrolyte near the edge. One possible reason for this delamination is excessive pressure buildup with high O2 flow in the over-sintered region. According to post test examination at the Massachusetts Institute of Technology, the electrochemical reactions have been recognized as one of the prevalent causes of their degradation. Specifically, two important degradation mechanisms were examined: (1) transport of Crcontaining species from steel interconnects into the oxygen electrode and LSC bond layers in SOECs, and (2) cation segregation and phase separation in the bond layer. INL conducted a workshop October 27, 2008 to discuss possible causes of degradation in a SOEC stack. Generally, it was agreed that the following are major degradation issues relating to SOECs: • Delamination of the O2-electrode and bond layer on the steam/O2-electrode side • Contaminants (Ni, Cr, Si, etc.) on reaction sites (triple phase boundary) • Loss of electrical/ionic conductivity of electrolyte.

  18. Integrated High-Level Waste System Planning - Utilizing an Integrated Systems Planning Approach to Ensure End-State Definitions are Met and Executed - 13244

    SciTech Connect (OSTI)

    Ling, Lawrence T. [URS-Savannah River Remediation, Savannah River Site, Building 766-H Room 2205, Aiken, SC 29808 (United States)] [URS-Savannah River Remediation, Savannah River Site, Building 766-H Room 2205, Aiken, SC 29808 (United States); Chew, David P. [URS-Savannah River Remediation, Savannah River Site, Building 766-H Room 2426, Aiken, SC 29808 (United States)] [URS-Savannah River Remediation, Savannah River Site, Building 766-H Room 2426, Aiken, SC 29808 (United States)

    2013-07-01T23:59:59.000Z

    The Savannah River Site (SRS) is a Department of Energy site which has produced nuclear materials for national defense, research, space, and medical programs since the 1950's. As a by-product of this activity, approximately 37 million gallons of high-level liquid waste containing approximately 292 million curies of radioactivity is stored on an interim basis in 45 underground storage tanks. Originally, 51 tanks were constructed and utilized to support the mission. Four tanks have been closed and taken out of service and two are currently undergoing the closure process. The Liquid Waste System is a highly integrated operation involving safely storing liquid waste in underground storage tanks; removing, treating, and dispositioning the low-level waste fraction in grout; vitrifying the higher activity waste at the Defense Waste Processing Facility; and storing the vitrified waste in stainless steel canisters until permanent disposition. After waste removal and processing, the storage and processing facilities are decontaminated and closed. A Liquid Waste System Plan (hereinafter referred to as the Plan) was developed to integrate and document the activities required to disposition legacy and future High-Level Waste and to remove from service radioactive liquid waste tanks and facilities. It establishes and records a planning basis for waste processing in the liquid waste system through the end of the program mission. The integrated Plan which recognizes the challenges of constrained funding provides a path forward to complete the liquid waste mission within all regulatory and legal requirements. The overarching objective of the Plan is to meet all Federal Facility Agreement and Site Treatment Plan regulatory commitments on or ahead of schedule while preserving as much life cycle acceleration as possible through incorporation of numerous cost savings initiatives, elimination of non-essential scope, and deferral of other scope not on the critical path to compliance. There is currently a premium on processing and storage space in the radioactive liquid waste tank system. To enable continuation of risk reduction initiatives, the Plan establishes a processing strategy that provides tank space required to meet, or minimizes the impacts to meeting, programmatic objectives. The Plan also addresses perturbations in funding and schedule impacts. (authors)

  19. A radiation-hardened, low-noise, high-speed, integrated charge preamplifier for the Superconducting Supercollider 

    E-Print Network [OSTI]

    Ling, Kuok Young

    1989-01-01T23:59:59.000Z

    nuclear physicists and researchers in the world are still trying to institute an agreeable set of technical requirements and specifications for the SSC; a. number of workshops similar to [20] have been or will be organized throughout the world... and specifications imposed on the charge preamplifier system by the SSC. At the same time, it also justifies the entirely new approach, which combines radiation ? hardness, low ? uoise, high ? speed, and full integration, undertaken by this research. In chapter...

  20. Throughput-cost analysis of optical flow switching

    E-Print Network [OSTI]

    Chan, Vincent W. S.

    In this paper, we employ a cost model embodying major sources of capital expenditure (CapEx) to compare the throughput-cost tradeoff offered by optical flow switching to that of more traditional optical network architectures.

  1. Maximizing the throughput of large ad hoc wireless networks

    E-Print Network [OSTI]

    Hua, Y; Huang, Y; Garcia-Luna-Aceves, J J

    2006-01-01T23:59:59.000Z

    multi-input, single-output (MISO) protocol. During eachthe maximum throughput of the MISO protocol, in bits-meters/s/ Hz/node, is C MISO = (n ? 1) A log 2 1 + 2n P T ? h

  2. Using Channel Output Feedback to Increase Throughput in Hybrid-ARQ

    E-Print Network [OSTI]

    Agrawal, Mayur; Love, David J; Balakrishnan, Venkataramanan

    2011-01-01T23:59:59.000Z

    Since its inclusion in the High Speed Downlink Packet Access (HSPDA) standard, the hybrid-ARQ protocol has become very popular in packet transmission schemes. Hybrid-ARQ combines the normal automatic repeat request (ARQ) method with error correction codes to increase reliability and throughput. The use of rate-compatible punctured turbo codes has been shown to work well for block fading channels. In this paper, we look at improving upon this performance using feedback information from the receiver; in particular, using a turbo code in conjunction with a proposed linear feedback code for the Rayleigh fading channels. The new hybrid-ARQ scheme is extended to various different multiple-antenna scenarios (MIMO/MISO/SISO) with varying amounts of feedback information. Simulations are given to illustrate gains in throughput.

  3. Integration of High-Temperature Gas-Cooled Reactors into Industrial Process Applications

    SciTech Connect (OSTI)

    Lee Nelson

    2009-10-01T23:59:59.000Z

    This report is a preliminary comparison of conventional and potential HTGR-integrated processesa in several common industrial areas: ? Producing electricity via a traditional power cycle ? Producing hydrogen ? Producing ammonia and ammonia-derived products, such as fertilizer ? Producing gasoline and diesel from natural gas or coal ? Producing substitute natural gas from coal, and ? Steam-assisted gravity drainage (extracting oil from tar sands).

  4. High-Integrity Software, Computation and the Scientific Method Les Hatton, CISM, Kingston University, UK

    E-Print Network [OSTI]

    Hatton, Les

    -critical systems. Such systems on failure, have a direct impact on human safety or indirectly by dam- aging-integrity systems are fundamentally those systems which on failure, have a significant impact on humans, or imaging software. · Mission-critical systems. Such systems on failure, are typically associated

  5. Very high frequency GaAlAs laser field-effect transistor monolithic integrated circuit

    SciTech Connect (OSTI)

    Ury, I.; Lau, K.Y.; Bar-Chaim, N.; Yariv, A.

    1982-07-15T23:59:59.000Z

    A very low threshold GaAlAs buried heterostructure laser has been monolithically integrated with a recessed structure metal-semiconductor field-effect transistor on a semi-insulating substrate. At cw operation, the device has a direct modulation bandwidth of at least 4 GHz.

  6. Integrated High Temperature Coal to Hydrogen System with CO2 Separation: Semi-Annual Progress Report 1

    SciTech Connect (OSTI)

    Ruud, J A; Ku, A; Ramaswamy, V; Wei, W

    2005-12-21T23:59:59.000Z

    This is the first semi-annual progress report for the program "Integrated High Temperature Coal to Hydrogen System with CO2 Separation." The objective of the program is to develop a detailed design for a single high-temperature syngas-cleanup module to produce a pure stream of H2 from a coal-based system and to develop the new high-temperature membrane materials at the core of that design. The novel one-box process combines a shift reactor with a high-temperature CO2-selective membrane to convert CO to CO2, remove sulfur compounds, and remove CO2 in a simple, compact, fully integrated system. In the first six months of the program, a conceptual design for the one-box system was developed in Task 1 and the performance targets for the system and the membrane were evaluated. In Task 2.1 processes were developed for creating pore architectures in ceramics that are applicable to membrane structures. In Task 2.2, candidate materials were identified that have the potential for separation of CO2 and H2S at high temperatures.

  7. High-performance carbon-nanotube-based complementary field-effect-transistors and integrated circuits with yttrium oxide

    SciTech Connect (OSTI)

    Liang, Shibo; Zhang, Zhiyong, E-mail: zyzhang@pku.edu.cn; Si, Jia; Zhong, Donglai; Peng, Lian-Mao, E-mail: lmpeng@pku.edu.cn [Key Laboratory for the Physics and Chemistry of Nanodevices, Department of Electronics, Peking University, Beijing 100871 (China)

    2014-08-11T23:59:59.000Z

    High-performance p-type carbon nanotube (CNT) transistors utilizing yttrium oxide as gate dielectric are presented by optimizing oxidization and annealing processes. Complementary metal-oxide-semiconductor (CMOS) field-effect-transistors (FETs) are then fabricated on CNTs, and the p- and n-type devices exhibit symmetrical high performances, especially with low threshold voltage near to zero. The corresponding CMOS CNT inverter is demonstrated to operate at an ultra-low supply voltage down to 0.2?V, while displaying sufficient voltage gain, high noise margin, and low power consumption. Yttrium oxide is proven to be a competitive gate dielectric for constructing high-performance CNT CMOS FETs and integrated circuits.

  8. SEPARATION OF TWO CONTRIBUTIONS TO THE HIGH ENERGY EMISSION OF CYGNUS X-1: POLARIZATION MEASUREMENTS WITH INTEGRAL SPI

    SciTech Connect (OSTI)

    Jourdain, E.; Roques, J. P.; Chauvin, M.; Clark, D. J. [Universite de Toulouse, UPS-OMP IRAP, Toulouse (France); CNRS, IRAP, 9 Av. colonel Roche, BP 44346, F-31028 Toulouse cedex 4 (France)

    2012-12-10T23:59:59.000Z

    Operational since 2002 on board the INTEGRAL observatory, the SPI spectrometer can be used to perform polarization measurements in the hard X-ray/soft{gamma}-ray domain ({approx}130 keV-8 MeV). However, this phenomenon is complex to measure at high energy and requires high fluxes. Cyg X-1 appears to be the best candidate amongst the X-ray binaries since it is one of the brightest persistent sources in this energy domain. Furthermore, a polarized component has recently been reported above 400 keV from IBIS data. We have therefore dedicated our efforts to developing the required tools to study the polarization in the INTEGRAL SPI data and have first applied them to 2.6 Ms of Cyg X-1 observations, covering 6.5 years of the INTEGRAL mission. We have found that the high energy emission of Cyg X-1 is indeed polarized, with a mean polarization fraction of 76% {+-} 15% at a position angle estimated to be 42 Degree-Sign {+-} 3 Degree-Sign , for energies above 230 keV. The polarization fraction clearly increases with energy. In the 130-230 keV band, the polarization fraction is lower than 20%, but exceeds 75% between 370 and 850 keV, with the (total) emission vanishing above this energy. This result strongly suggests that the emission originates from the jet structure known to emit in the radio domain. The same synchrotron process could be responsible for the emission from radio to MeV, implying the presence of high energy electrons. This illustrates why the polarization of the high energy emission in compact objects is an increasingly important observational objective.

  9. High order three part split symplectic integrators: Efficient techniques for the long time simulation of the disordered discrete nonlinear Schroedinger equation

    E-Print Network [OSTI]

    Ch. Skokos; E. Gerlach; J. D. Bodyfelt; G. Papamikos; S. Eggl

    2014-04-28T23:59:59.000Z

    While symplectic integration methods based on operator splitting are well established in many branches of science, high order methods for Hamiltonian systems that split in more than two parts have not been studied in great detail. Here, we present several high order symplectic integrators for Hamiltonian systems that can be split in exactly three integrable parts. We apply these techniques, as a practical case, for the integration of the disordered, discrete nonlinear Schroedinger equation (DDNLS) and compare their efficiencies. Three part split algorithms provide effective means to numerically study the asymptotic behavior of wave packet spreading in the DDNLS - a hotly debated subject in current scientific literature.

  10. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in

  11. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    was designed using riboflavin as the photoinitiator. Allwith 6 µL of 0.1% (w/v) riboflavin (Sigma) and 1.25 µL 100%

  12. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    1994-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  13. High throughput analysis of samples in flowing liquid

    DOE Patents [OSTI]

    Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)

    2001-01-01T23:59:59.000Z

    Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.

  14. Potential of High-Throughput Experimentation with Ammonia Borane...

    Broader source: Energy.gov (indexed) [DOE]

    and theory - Materials Discovery DOE BES Hydrogen Fuel Initiative * Structure and dynamics (Neutron and NMR) - Experimental and computational studies of di- hydrogen bonding...

  15. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    and large-area graphene plane as a floor. Preparation ofgraphene was dried and prepared for dye coating. Dye Preparation and

  16. Constant pressure high throughput membrane permeation testing system

    DOE Patents [OSTI]

    Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.

    2014-09-02T23:59:59.000Z

    The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.

  17. High mass throughput particle generation using multiple nozzle spraying

    DOE Patents [OSTI]

    Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Creve Coeur, MO)

    2009-03-03T23:59:59.000Z

    Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

  18. Technology Offer High-throughput Algorithm for Automated

    E-Print Network [OSTI]

    reliability enables the same LC-MS analyses with less human resources as manual correction is not necessary Chemical industry: identification and quantitation of chemical composition of various analytes, e.g. oils

  19. Optical Multiplexing for High-Throughput Spectroscopic Analysis. 

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    Implantable optical biosensors are being developed as aids for medical monitoring. Such optical biosensors are analyzed for performance in dynamic sensor testing environment. Multi-Frequency Phase Fluorometer (MFPF) is a key measuring device...

  20. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01T23:59:59.000Z

    Nat Genet, Jun 2012. [LHW + 09] Heng Li, Bob Handsaker, Alec25(16):2078–2079, [Li11] Heng Li. Tabix: fast retrieval ofYang, Chun-Qing Song, Le-Heng Wang, Chao Liu, Yan Fu, Zuo-

  1. An apparatus for high throughput muscle cell experimentation

    E-Print Network [OSTI]

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01T23:59:59.000Z

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  2. Towards Experimental Annotation of Genes by High Throughput Sequencing

    SciTech Connect (OSTI)

    Bradbury, Andrew [Los Alamos National Laboratory

    2010-06-03T23:59:59.000Z

    Andrew Bradbury of Los Alamos National Laboratory discusses turning annotation into a sequencing pipeline on June 3, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  3. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, S.

    1994-07-12T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  4. Operational streamlining in a high-throughput genome sequencing center

    E-Print Network [OSTI]

    Person, Kerry P. (Kerry Patrick)

    2006-01-01T23:59:59.000Z

    Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...

  5. Methods and devices for high-throughput dielectrophoretic concentration

    DOE Patents [OSTI]

    Simmons, Blake A. (San Francisco, CA); Cummings, Eric B. (Livermore, CA); Fiechtner, Gregory J. (Germantown, MD); Fintschenko, Yolanda (Livermore, CA); McGraw, Gregory J. (Ann Arbor, MI); Salmi, Allen (Escalon, CA)

    2010-02-23T23:59:59.000Z

    Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.

  6. Targeted Tandem Mass Spectrometry for High-Throughput Comparative...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    states. Herein, we report on a targeted LC-MSMS capability realized with a 7 Tesla Fourier transform ion cyclotron resonance (FTICR) mass spectrometer equipped with a...

  7. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Broader source: Energy.gov (indexed) [DOE]

    - 50 cm -1 ) red-shifts upon adsorption *Can be complex, depending on exact adsorption environment *Partial charge transfer weakens H-H bond, red-shift *Are such strong...

  8. High-Throughput Transfer Imprinting for Organic Semiconductors

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    semiconductors because heat and pressure used in thermal nanoimprint do not damage functional materials. However, issues such as residual layer removal and mold contamination still limit the application of nanoimprint for organic semiconductor patterning...

  9. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    S. , and Marra, M. Resuspension of DNA Sequencing Reactionstability. (A) Sample resuspension in low-concentrationand used as the sole resuspension buffer following sample

  10. High-throughput methods for characterizing the immune repertoire

    E-Print Network [OSTI]

    Laserson, Uri

    2013-01-01T23:59:59.000Z

    The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...

  11. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    24 2.5 Demonstration of PGN based Supercapacitor2-11 (a) CV curves of supercapacitor based on as-grown PGNFigure 2-12 CV curves of supercapacitor based on HNO3 acid

  12. High-Throughput Transfer Imprinting for Organic Semiconductors 

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    . In this work, nanoimprint-based transfer imprinting of organic semiconductor is studied. In the same time the suggested technique is simulated with COMSOL multi-physics simulator to understand its mechanism. This transfer printing technique utilize thermal...

  13. Algorithms for Next-Generation High-Throughput Sequencing Technologies

    E-Print Network [OSTI]

    Kao, Wei-Chun

    2011-01-01T23:59:59.000Z

    parameters for 4 different tiles of the 76- cycle PhiX174scores at error tolerance . . . . 2.9 Tile-specific errorsection). Normalizing by the tile-wide average c t is to

  14. High-Throughput Characterization of Porous Materials Using Graphics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3

  15. High-Throughput Dry Processes for Large-Area Devices

    SciTech Connect (OSTI)

    BUSS,RICHARD J.; HEBNER,GREGORY A.; RUBY,DOUGLAS S.; YANG,PIN

    1999-11-01T23:59:59.000Z

    In October 1996, an interdisciplinary team began a three-year LDRD project to study the plasma processes of reactive ion etching and plasma-enhanced chemical vapor deposition on large-area silicon devices. The goal was to develop numerical models that could be used in a variety of applications for surface cleaning, selective etching, and thin-film deposition. Silicon solar cells were chosen as the experimental vehicle for this project because an innovative device design was identified that would benefit from immediate performance improvement using a combination of plasma etching and deposition processes. This report presents a summary of the technical accomplishments and conclusions of the team.

  16. METHODS AND APPLICATIONS High-throughput instant quantification of

    E-Print Network [OSTI]

    Ihee, Hyotcherl

    based on photoactive yellow protein turn off/on label Youngmin Kim,1,2 Prabhakar Ganesan,1 on the Photoactive yellow protein turn Off/On Label (POOL) system that can instantly quan- tify the concentration Gel Electrophoresis; POOL, PYP turn Off/On Label; PYP, Photoactive Yellow Protein; SUMO, Small

  17. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  18. NETL Studies High Throughput Membrane Screening | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL Scientist Wins 2011NETLNETL

  19. Potential of High-Throughput Experimentation with Ammonia Borane Solid

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in235-1Department of60 DATE:AnnualDepartment ofPotentialYield

  20. High Throughput Combinatorial Screening of Biometic Metal-Organic Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor Military

  1. High Throughput/Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor

  2. High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e eforApproaches |

  3. High-Throughput and Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa

  4. Integrating High Penetrations of Solar in the Western United States: Results of the Western Wind and Solar Integration Study Phase 2 (Poster)

    SciTech Connect (OSTI)

    Bird, L.; Lew, D.

    2013-10-01T23:59:59.000Z

    This poster presents a summary of the results of the Western Wind and Solar Integration Study Phase 2.

  5. Integrated high-resolution physical and comparative gene maps in horses

    E-Print Network [OSTI]

    Brinkmeyer Langford, Candice Lea

    2007-04-25T23:59:59.000Z

    Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/) genome browsers. A plethora of resources has become available in other species as well. Linkage maps marked the beginning of the development of dense gene maps in the chicken... panel have been used for integrating linkage and cytogenetic information and to align the maps to the sequence information (Morisson et al. 2002; Leroux et al. 2005; Morisson et al. 2005). Several BAC libraries including the TAM31, TAM32, and TAM33...

  6. Development of a High Latent Effectiveness Energy Recovery Ventilator with Integration into Rooftop Package Equipment

    SciTech Connect (OSTI)

    Gregory M. Dobbs; Norberto O. Lemcoff; Frederick J. Cogswell; Jeffrey T. Benolt

    2006-03-01T23:59:59.000Z

    This Final Report covers the Cooperative Program carried out to design and optimize an enhanced flat-plate energy recovery ventilator and integrate it into a packaged unitary (rooftop) air conditioning unit. The project objective was to optimize the design of a flat plate energy recovery ventilator (ERV) core that compares favorably to flat plate air-to-air heat exchanger cores on the market and to cost wise to small enthalpy wheel devices. The benefits of an integrated unit incorporating an enhanced ERV core and a downsized heating/cooling unit were characterized and the design of an integrated unit considering performance and cost was optimized. Phase I was to develop and optimize the design of a membrane based heat exchanger core. Phase II was the creation and observation of a system integrated demonstrator unit consisting of the Enhanced Energy Recovery Ventilator (EERV) developed in Phase I coupled to a standard Carrier 50HJ rooftop packaged unitary air conditioning unit. Phase III was the optimization of the system prior to commercialization based on the knowledge gained in Phase II. To assure that the designs chosen have the possibility of meeting cost objectives, a preliminary manufacturability and production cost study was performed by the Center for Automation Technologies at RPI. Phase I also included a preliminary design for the integrated unit to be further developed in Phase II. This was to assure that the physical design of the heat exchanger designed in Phase I would be acceptable for use in Phase II. An extensive modeling program was performed by the Center for Building Performance & Diagnostics of CMU. Using EnergyPlus as the software, a typical office building with multiple system configurations in multiple climatic zones in the US was simulated. The performance of energy recovery technologies in packaged rooftop HVAC equipment was evaluated. The experimental program carried out in Phases II and III consisted of fabricating and testing a demonstrator unit using Carrier Comfort Network (CCN) based controls. Augmenting the control signals, CCN was also used to monitor and record additional performance data that supported modeling and conceptual understanding. The result of the testing showed that the EERV core developed in Phase I recovered energy in the demonstrator unit at the expected levels based on projections. In fact, at near-ARI conditions the core recovered about one ton of cooling enthalpy when operating with a three-ton rooftop packaged unit.

  7. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01T23:59:59.000Z

    solar PV and distributed generation. UTILITY RATE DESIGN ANDutility concerns that a high penetration of inverter-based solar energy systems along with other distributed generation

  8. The role of SEA in integrating and balancing high policy objectives in European cohesion funding programmes

    SciTech Connect (OSTI)

    Jiricka, Alexandra, E-mail: alexandra.jiricka@boku.ac.at; Proebstl, Ulrike, E-mail: ulrike.proebstl@boku.ac.at

    2013-01-15T23:59:59.000Z

    Funding programmes for European cohesion policy are a crucial tool to support the sustainability goals of the European Union and national policies of its member states. All these funding programmes require a Strategic Environmental Assessment (SEA) to enhance sustainable development. This article compares five first SEA applications at cohesion policy level to discuss challenges, limitations and benefits of this instrument. In order to support the SEA-process a 'Handbook on SEA for Cohesion Policy 2007-13' (GRDP 2006) was developed. The paper examines the special requirements and challenges at the programme level given the special conditions for stakeholder involvement, integration of SEA in the programme development process and strategies to cope with uncertainties to ensure real compatibility with policy goals. Using action research and in-depth interviews with SEA planners and programme managers enabled us to analyse the suitability of the methodology proposed by the handbook. The results show that some recommendations of the handbook should be changed in order to increase the transparency and to enhance the standard and comparability of the SEA-documents. Overall the SEA proved to be a rather successful tool for the integration of sustainability goals at the EU and national policy levels. Its particular strengths emerged as the process makes uncertainties visible and leads to possible redefinitions while maintaining actual policy goals. - Highlights: Black-Right-Pointing-Pointer Comparing five case studies of first applications of SEA at cohesion policy level. Black-Right-Pointing-Pointer Overall the SEA proved to be a rather successful tool for the integration of sustainability goals. Black-Right-Pointing-Pointer The study makes uncertainties visible and shows how SEA could lead to possible redefinitions.

  9. Astron. Nachr./AN 32X (200X) X, XXX--XXX OASIS HighResolution Integral Field Spectroscopy of the SAURON

    E-Print Network [OSTI]

    Bureau, Martin

    Astron. Nachr./AN 32X (200X) X, XXX--XXX OASIS High­Resolution Integral Field Spectroscopy) galaxies in the SAURON survey using the OASIS integral field spectrograph. The OASIS observations explore velocity dispersion #24; > 120 km s 1 were observed with OASIS, covering well the original SAURON

  10. Integrated High Speed Intelligent Utility Tie Unit for Disbursed/Renewable Generation Facilities Worakarn Wongsaichua, Wei-Jen Lee Soontorn Oraintara Chiman Kwan Frank Zhang

    E-Print Network [OSTI]

    Oraintara, Soontorn

    Integrated High Speed Intelligent Utility Tie Unit for Disbursed/Renewable Generation Facilities is to rejuvenate the idea of integrated resource planning and promote the distributed generation via traditional or renewable generation facilities for the deregulated utility systems. Fuel cell and photovoltaic are the most

  11. Millimeter-wave GaN high electron mobility transistors and their integration with silicon electronics

    E-Print Network [OSTI]

    Chung, Jinwook W. (Jinwook Will)

    2011-01-01T23:59:59.000Z

    In spite of the great progress in performance achieved during the last few years, GaN high electron mobility transistors (HEMTs) still have several important issues to be solved for millimeter-wave (30 ~ 300 GHz) applications. ...

  12. Transmit field pattern control for high field magnetic resonance imaging with integrated RF current sources 

    E-Print Network [OSTI]

    Kurpad, Krishna Nagaraj

    2005-11-01T23:59:59.000Z

    The primary design criterion for RF transmit coils for MRI is uniform transverse magnetic (B1) field. Currently, most high frequency transmit coils are designed as periodic, symmetric structures that are resonant at the ...

  13. Policies and Programs to Integrate High Penetrations of Variable Renewable Energy (Presentation)

    SciTech Connect (OSTI)

    Cochran, J.

    2012-06-01T23:59:59.000Z

    The goals of this project are to highlight the diverse approaches for enabling high renewable energy penetration; synthesize lessons on effective policies and programs and present avenues for action to energy ministers and other stakeholders.

  14. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01T23:59:59.000Z

    high levels of short circuit current, but the addition ofsum to large short circuit currents. ? Utility protectionthe cell, is the short-circuit current of the cell. The fill

  15. Integration of a high efficiency flue gas cleanup process into advanced power systems

    SciTech Connect (OSTI)

    Hoffman, J.S.; Pennline, H.W.; Yeh, J.T.; Ratafia-Brown, J.A.; Gorokhov, V.A.

    1994-12-31T23:59:59.000Z

    The Moving-Bed Copper Oxide Process, a dry, regenerable flue gas cleanup technology, can simultaneously remove sulfur dioxide (SO{sub 2}) and nitrogen oxide (NO{sub x}) emissions from the flue gases generated by coal combustion. While this advanced air pollution abatement process technology has only been previously considered for conventional utility system applications, its unique design characteristics make it quite advantageous for use in advanced power systems, such as those pulverized-coal-fired systems defined in the US Department of Energy`s Combustion 2000 Initiative. Integration of this flue gas cleanup process into the advanced power systems is technically and economically assessed and compared with several commercially available flue gas cleanup processes. An update on the status of the Moving-Bed Copper oxide Process development is also presented.

  16. Analysis of system wide distortion in an integrated power system utilizing a high voltage DC bus and silicon carbide power devices

    E-Print Network [OSTI]

    Fallier, William F. (William Frederick)

    2007-01-01T23:59:59.000Z

    This research investigates the distortion on the electrical distribution system for a high voltage DC Integrated Power System (IPS). The analysis was concentrated on the power supplied to a propulsion motor driven by an ...

  17. VESPA: Software to Facilitate Genomic Annotation of Prokaryotic Organisms Through Integration of Proteomic and Transcriptomic Data

    SciTech Connect (OSTI)

    Peterson, Elena S.; McCue, Lee Ann; Rutledge, Alexandra C.; Jensen, Jeffrey L.; Walker, Julia; Kobold, Mark A.; Webb, Samantha R.; Payne, Samuel H.; Ansong, Charles; Adkins, Joshua N.; Cannon, William R.; Webb-Robertson, Bobbie-Jo M.

    2012-04-25T23:59:59.000Z

    Visual Exploration and Statistics to Promote Annotation (VESPA) is an interactive visual analysis software tool that facilitates the discovery of structural mis-annotations in prokaryotic genomes. VESPA integrates high-throughput peptide-centric proteomics data and oligo-centric or RNA-Seq transcriptomics data into a genomic context. The data may be interrogated via visual analysis across multiple levels of genomic resolution, linked searches, exports and interaction with BLAST to rapidly identify location of interest within the genome and evaluate potential mis-annotations.

  18. A One System Integrated Approach to Simulant Selection for Hanford High Level Waste Mixing and Sampling Tests

    SciTech Connect (OSTI)

    Thien, Mike G. [Washington River Protection Solutions, LLC, Richland, WA (United States); Barnes, Steve M. [URS, Richland, WA (United States)

    2013-01-17T23:59:59.000Z

    The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capabilities using simulated Hanford High-Level Waste (HLW) formulations. This represents one of the largest remaining technical issues with the high-level waste treatment mission at Hanford. Previous testing has focused on very specific TOC or WTP test objectives and consequently the simulants were narrowly focused on those test needs. A key attribute in the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2010-2 is to ensure testing is performed with a simulant that represents the broad spectrum of Hanford waste. The One System Integrated Project Team is a new joint TOC and WTP organization intended to ensure technical integration of specific TOC and WTP systems and testing. A new approach to simulant definition has been mutually developed that will meet both TOC and WTP test objectives for the delivery and receipt of HLW. The process used to identify critical simulant characteristics, incorporate lessons learned from previous testing, and identify specific simulant targets that ensure TOC and WTP testing addresses the broad spectrum of Hanford waste characteristics that are important to mixing, sampling, and transfer performance are described.

  19. A One System Integrated Approach to Simulant Selection for Hanford High Level Waste Mixing and Sampling Tests - 13342

    SciTech Connect (OSTI)

    Thien, Mike G. [Washington River Protection Solutions, LLC, P.O Box 850, Richland WA, 99352 (United States)] [Washington River Protection Solutions, LLC, P.O Box 850, Richland WA, 99352 (United States); Barnes, Steve M. [Waste Treatment Plant, 2435 Stevens Center Place, Richland WA 99354 (United States)] [Waste Treatment Plant, 2435 Stevens Center Place, Richland WA 99354 (United States)

    2013-07-01T23:59:59.000Z

    The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capabilities using simulated Hanford High-Level Waste (HLW) formulations. This represents one of the largest remaining technical issues with the high-level waste treatment mission at Hanford. Previous testing has focused on very specific TOC or WTP test objectives and consequently the simulants were narrowly focused on those test needs. A key attribute in the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2010-2 is to ensure testing is performed with a simulant that represents the broad spectrum of Hanford waste. The One System Integrated Project Team is a new joint TOC and WTP organization intended to ensure technical integration of specific TOC and WTP systems and testing. A new approach to simulant definition has been mutually developed that will meet both TOC and WTP test objectives for the delivery and receipt of HLW. The process used to identify critical simulant characteristics, incorporate lessons learned from previous testing, and identify specific simulant targets that ensure TOC and WTP testing addresses the broad spectrum of Hanford waste characteristics that are important to mixing, sampling, and transfer performance are described. (authors)

  20. www.westfalenwind.de 1 ,,Grid integration of high volumes of Renewable Energies

    E-Print Network [OSTI]

    Noé, Reinhold

    on Decentralized Power Systems 2012 WestfalenWIND GmbH Leihbühl 21 33165 Lichtenau #12;www.westfalenwind.de 2 What wind and solar · high peak power compared to average power · decentralized systems reduce average transport distance of electricity form generation to consumers, but · Power balancing on a local or regional

  1. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01T23:59:59.000Z

    stability became a serious concern for the studied system when 40% power (System Protection Analysis  47  Reactive Power Deficiency Analysis  .. 47  Dynamic Stability Stability for Residential Customers Due to High Photovoltaic Penetrations Yan, R,; Saha, T.K IEEE TRANSACTIONS OF POWER SYSTEMS,

  2. High-Responsivity Graphene-Boron Nitride Photodetector and Autocorrelator in a Silicon Photonic Integrated Circuit

    E-Print Network [OSTI]

    Shiue, Ren-Jye; Wang, Yifei; Peng, Cheng; Robertson, Alexander D; Efetov, Dimitri; Assefa, Solomon; Koppens, Frank H L; Hone, James; Englund, Dirk

    2015-01-01T23:59:59.000Z

    Graphene and other two-dimensional (2D) materials have emerged as promising materials for broadband and ultrafast photodetection and optical modulation. These optoelectronic capabilities can augment complementary metal-oxide-semiconductor (CMOS) devices for high-speed and low-power optical interconnects. Here, we demonstrate an on-chip ultrafast photodetector based on a two-dimensional heterostructure consisting of high-quality graphene encapsulated in hexagonal boron nitride. Coupled to the optical mode of a silicon waveguide, this 2D heterostructure-based photodetector exhibits a maximum responsivity of 0.36 A/W and high-speed operation with a 3 dB cut-off at 42 GHz. From photocurrent measurements as a function of the top-gate and source-drain voltages, we conclude that the photoresponse is consistent with hot electron mediated effects. At moderate peak powers above 50 mW, we observe a saturating photocurrent consistent with the mechanisms of electron-phonon supercollision cooling. This nonlinear photorespo...

  3. Maglev vehicles and superconductor technology: Integration of high-speed ground transportation into the air travel system

    SciTech Connect (OSTI)

    Johnson, L.R.; Rote, D.M.; Hull, J.R.; Coffey, H.T.; Daley, J.G.; Giese, R.F.

    1989-04-01T23:59:59.000Z

    This study was undertaken to (1) evaluate the potential contribution of high-temperature superconductors (HTSCs) to the technical and economic feasibility of magnetically levitated (maglev) vehicles, (2) determine the status of maglev transportation research in the United States and abroad, (3) identify the likelihood of a significant transportation market for high-speed maglev vehicles, and (4) provide a preliminary assessment of the potential energy and economic benefits of maglev systems. HTSCs should be considered as an enhancing, rather than an enabling, development for maglev transportation because they should improve reliability and reduce energy and maintenance costs. Superconducting maglev transportation technologies were developed in the United States in the late 1960s and early 1970s. Federal support was withdrawn in 1975, but major maglev transportation programs were continued in Japan and West Germany, where full-scale prototypes now carry passengers at speeds of 250 mi/h in demonstration runs. Maglev systems are generally viewed as very-high-speed train systems, but this study shows that the potential market for maglev technology as a train system, e.g., from one downtown to another, is limited. Rather, aircraft and maglev vehicles should be seen as complementing rather than competing transportation systems. If maglev systems were integrated into major hub airport operations, they could become economical in many relatively high-density US corridors. Air traffic congestion and associated noise and pollutant emissions around airports would also be reduced. 68 refs., 26 figs., 16 tabs.

  4. Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

    SciTech Connect (OSTI)

    Corwin, William R [ORNL; Burchell, Timothy D [ORNL; Katoh, Yutai [ORNL; McGreevy, Timothy E [ORNL; Nanstad, Randy K [ORNL; Ren, Weiju [ORNL; Snead, Lance Lewis [ORNL; Wilson, Dane F [ORNL

    2008-08-01T23:59:59.000Z

    Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of the structural materials needed to ensure their safe and reliable operation. The focus of this document will be the overall range of DOE's structural materials research activities being conducted to support VHTR development. By far, the largest portion of material's R&D supporting VHTR development is that being performed directly as part of the Next-Generation Nuclear Plant (NGNP) Project. Supplementary VHTR materials R&D being performed in the DOE program, including university and international research programs and that being performed under direct contracts with the American Society for Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, will also be described. Specific areas of high-priority materials research that will be needed to deploy the NGNP and provide a basis for subsequent VHTRs are described, including the following: (1) Graphite: (a) Extensive unirradiated materials characterization and assessment of irradiation effects on properties must be performed to qualify new grades of graphite for nuclear service, including thermo-physical and mechanical properties and their changes, statistical variations from billot-to-billot and lot-to-lot, creep, and especially, irradiation creep. (b) Predictive models, as well as codification of the requirements and design methods for graphite core supports, must be developed to provide a basis for licensing. (2) Ceramics: Both fibrous and load-bearing ceramics must be qualified for environmental and radiation service as insulating materials. (3) Ceramic Composites: Carbon-carbon and SiC-SiC composites must be qualified for specialized usage in selected high-temperature components, such as core stabilizers, control rods, and insulating covers and ducting. This will require development of component-specific designs and fabrication processes, materials characterization, assessment of environmental and irradiation effects, and establishment of codes and standards for materials testing and design requirements. (4) Pressure Vessel Steels: (a) Qualification of short-term, high-temperature properties of light water rea

  5. THE INTEGRATION OF PROCESS HEAT APPLICATIONS TO HIGH TEMPERATURE GAS REACTORS

    SciTech Connect (OSTI)

    Michael G. McKellar

    2011-11-01T23:59:59.000Z

    A high temperature gas reactor, HTGR, can produce industrial process steam, high-temperature heat-transfer gases, and/or electricity. In conventional industrial processes, these products are generated by the combustion of fossil fuels such as coal and natural gas, resulting in significant emissions of greenhouse gases such as carbon dioxide. Heat or electricity produced in an HTGR could be used to supply process heat or electricity to conventional processes without generating any greenhouse gases. Process heat from a reactor needs to be transported by a gas to the industrial process. Two such gases were considered in this study: helium and steam. For this analysis, it was assumed that steam was delivered at 17 MPa and 540 C and helium was delivered at 7 MPa and at a variety of temperatures. The temperature of the gas returning from the industrial process and going to the HTGR must be within certain temperature ranges to maintain the correct reactor inlet temperature for a particular reactor outlet temperature. The returning gas may be below the reactor inlet temperature, ROT, but not above. The optimal return temperature produces the maximum process heat gas flow rate. For steam, the delivered pressure sets an optimal reactor outlet temperature based on the condensation temperature of the steam. ROTs greater than 769.7 C produce no additional advantage for the production of steam.

  6. FLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization

    E-Print Network [OSTI]

    Liblit, Ben

    the usefulness of flexible channels in the context of 802.11-based networks. Current 802.11 hardware can provideFLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization Shravan for designing 802.11 wireless LANs (WLANs) using flexible channelization -- the choice of an appropriate channel

  7. Storage Performance Virtualization via Throughput and Latency Control

    E-Print Network [OSTI]

    Riska, Alma

    Storage Performance Virtualization via Throughput and Latency Control JIANYONG ZHANG, ANAND storage systems. A consequence of this trend is the need to serve multiple users and/or workloads of the underlying storage system; (2) couple rate and latency allocation in a single scheduler, making them less

  8. On the Throughput Capacity of Heterogeneous Wireless Networks

    E-Print Network [OSTI]

    Latchman, Haniph A.

    On the Throughput Capacity of Heterogeneous Wireless Networks Pan Li, Member, IEEE, and Yuguang of wireless networks. However, it is commonly assumed that all nodes in the network are identical. The issue of heterogeneous wireless networks with general network settings. Specifically, we consider an extended network

  9. Maximizing Throughput in Wireless Networks with Finite Internal Buffers

    E-Print Network [OSTI]

    Chang, Cheng-Shang

    Maximizing Throughput in Wireless Networks with Finite Internal Buffers Ching-Min Lien, Cheng of a discrete-time wireless network, where only certain sets of links can transmit simultaneously. It is well of the configuration vectors determines the capacity region of the wireless network. In the literature, packet

  10. Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting

    E-Print Network [OSTI]

    Vaze, Rahul

    1 Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting Communication System general case of arbitrarily varying energy arrivals is considered, where neither the future energy arrival strategy that invests available energy uniformly over all remaining slots until the next energy arrival

  11. Applying Speculative Technique to Improve TCP Throughput over Lossy Links

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    @ou.edu Abstract-- The throughput degradation of Transport Control Protocol (TCP) over lossy links due performance due to control hazards in CPU design. First, two types of loss events in networks with lossy links links are involved in TCP connections. The objective of this paper is to propose a protocol

  12. Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH)

    E-Print Network [OSTI]

    Rosen, Joseph

    Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH) using dual Montgomery County Campus, Rockville, Maryland 20850, USA * barakk@ee.bgu.ac.il Abstract: Fresnel incoherent Fresnel holography," Opt. Lett. 32(8), 912­914 (2007). 7. J. Rosen and G. Brooker, "Fluorescence

  13. Applying Speculative Technique to Improve TCP Throughput over Lossy Links

    E-Print Network [OSTI]

    Minnesota, University of

    , Mohammed Atiquzzaman Honeywell Labs 3660 Technology Drive Minneapolis, MN 55418, USA E-mail: haowei.bai@honeywell #12;Applying Speculative Technique to Improve TCP Throughput over Lossy Links Haowei Bai Honeywell Labs 3660 Technology Drive Minneapolis, MN 55418 haowei.bai@honeywell.com David Lilja Electrical

  14. Improving Bluetooth EDR Data Throughput Using FEC and Interleaving

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Improving Bluetooth EDR Data Throughput Using FEC and Interleaving Ling-Jyh Chen1 , Tony Sun2 Enhanced Data Rate (EDR) mode detailed in the new Bluetooth spec v2.0. We first studied the APT algorithm/IFEC coding schemes for the new EDR packet types, assessed their ability to alleviate the impact of burst

  15. High Sensitivity Proteomics Assisted Discovery of a Novel Operon...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the water oxidation reactions of the photosynthetic electron transport chain in plants, algae, and cyanobacteria. Utilizing a high-throughput proteomic analysis of isolated PSII...

  16. ascidiacea high genome: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Daniel S. (Daniel Southwick), 1977- 2004-01-01 3 Data Management for High-Throughput Genomics CERN Preprints Summary: Today's sequencing technology allows sequencing an individual...

  17. Integration of High Temperature Gas-cooled Reactor Technology with Oil Sands Processes

    SciTech Connect (OSTI)

    L.E. Demick

    2011-10-01T23:59:59.000Z

    This paper summarizes an evaluation of siting an HTGR plant in a remote area supplying steam, electricity and high temperature gas for recovery and upgrading of unconventional crude oil from oil sands. The area selected for this evaluation is the Alberta Canada oil sands. This is a very fertile and active area for bitumen recovery and upgrading with significant quantities piped to refineries in Canada and the U.S Additionally data on the energy consumption and other factors that are required to complete the evaluation of HTGR application is readily available in the public domain. There is also interest by the Alberta oil sands producers (OSP) in identifying alternative energy sources for their operations. It should be noted, however, that the results of this evaluation could be applied to any similar oil sands area.

  18. NREL/SCE High Penetration PV Integration Project: FY13 Annual Report

    SciTech Connect (OSTI)

    Mather, B. A.; Shah, S.; Norris, B. L.; Dise, J. H.; Yu, L.; Paradis, D.; Katiraei, F.; Seguin, R.; Costyk, D.; Woyak, J.; Jung, J.; Russell, K.; Broadwater, R.

    2014-06-01T23:59:59.000Z

    In 2010, the National Renewable Energy Laboratory (NREL), Southern California Edison (SCE), Quanta Technology, Satcon Technology Corporation, Electrical Distribution Design (EDD), and Clean Power Research (CPR) teamed to analyze the impacts of high penetration levels of photovoltaic (PV) systems interconnected onto the SCE distribution system. This project was designed specifically to benefit from the experience that SCE and the project team would gain during the installation of 500 megawatts (MW) of utility-scale PV systems (with 1-5 MW typical ratings) starting in 2010 and completing in 2015 within SCE's service territory through a program approved by the California Public Utility Commission (CPUC). This report provides the findings of the research completed under the project to date.

  19. An integrated workstation environment for modelling of high-frequency transistors

    E-Print Network [OSTI]

    Narayan, Sriram

    1990-01-01T23:59:59.000Z

    be seen in Chapter 4. N z K D 3 I L L. C 0 ld J2 4 0 8 0 C 41 L 0 Q. C M 0 c* c c tJ 0 0 0 0 C 0 id 0 0 dC (BDQ) QphJ/UBQg let C ': tnPAT ON PLANt NETUI0RK RNRLYZER Test l Cat tdr a. lan Cadle l Standards PE FREN, P...-formats which will be used by the C routines to do the fitting. 1. The HP8753A Network Analyzer The HP8753A is a 300 kHz ? 3 GHz network analyzer which is ideally suited for making measurements on high-frequency analog circuits which can be reduced to a, two...

  20. NLSEmagic: Nonlinear Schr\\"odinger Equation Multidimensional Matlab-based GPU-accelerated Integrators using Compact High-order Schemes

    E-Print Network [OSTI]

    Caplan, R M

    2012-01-01T23:59:59.000Z

    We present a simple to use, yet powerful code package called NLSEmagic to numerically integrate the nonlinear Schr\\"odinger equation in one, two, and three dimensions. NLSEmagic is a high-order finite-difference code package which utilizes graphic processing unit (GPU) parallel architectures. The codes running on the GPU are many times faster than their serial counterparts, and are much cheaper to run than on standard parallel clusters. The codes are developed with usability and portability in mind, and therefore are written to interface with MATLAB utilizing custom GPU-enabled C codes with the MEX-compiler interface. The packages are freely distributed, including user manuals and set-up files.

  1. High-performance broadband optical coatings on InGaN/GaN solar cells for multijunction device integration

    SciTech Connect (OSTI)

    Young, N. G., E-mail: ngyoung@engineering.ucsb.edu; Farrell, R. M.; Iza, M.; Speck, J. S. [Materials Department, University of California, Santa Barbara, California 93106 (United States); Perl, E. E.; Keller, S. [Department of Electrical and Computer Engineering, University of California, Santa Barbara, California 93106 (United States); Bowers, J. E.; Nakamura, S.; DenBaars, S. P. [Materials Department, University of California, Santa Barbara, California 93106 (United States); Department of Electrical and Computer Engineering, University of California, Santa Barbara, California 93106 (United States)

    2014-04-21T23:59:59.000Z

    We demonstrate InGaN/GaN multiple quantum well solar cells grown by metalorganic chemical vapor deposition on a bulk (0001) substrate with high-performance broadband optical coatings to improve light absorption. A front-side anti-reflective coating and a back-side dichroic mirror were designed to minimize front surface reflections across a broad spectral range and maximize rear surface reflections only in the spectral range absorbed by the InGaN, making the cells suitable for multijunction solar cell integration. Application of optical coatings increased the peak external quantum efficiency by 56% (relative) and conversion efficiency by 37.5% (relative) under 1 sun AM0 equivalent illumination.

  2. On Optimal Throughput-Energy Curve for Multi-hop Wireless Networks

    E-Print Network [OSTI]

    Hou, Y. Thomas

    Laboratory Washington, DC, USA Abstract--Network throughput and energy consumption are two important throughput under some energy constraint or minimizing energy consumption while satisfying some throughput, through- put and energy consumption are two key performance metrics that bear in the minds of network

  3. An Advanced Integrated Diffusion/Transport Method for the Design, Analysis and Optimization of the Very-High-Temperature Reactors

    SciTech Connect (OSTI)

    Farzad Rahnema; Dingkang Zhang; Abderrafi Ougouag; Frederick Gleicher

    2011-04-04T23:59:59.000Z

    The main objective of this research is to develop an integrated diffusion/transport (IDT) method to substantially improve the accuracy of nodal diffusion methods for the design and analysis of Very High Temperature Reactors (VHTR). Because of the presence of control rods in the reflector regions in the Pebble Bed Reactor (PBR-VHTR), traditional nodal diffusion methods do not accurately model these regions, within which diffusion theory breaks down in the vicinity of high neutron absorption and steep flux gradients. The IDT method uses a local transport solver based on a new incident flux response expansion method in the controlled nodes. Diffusion theory is used in the rest of the core. This approach improves the accuracy of the core solution by generating transport solutions of controlled nodes while maintaining computational efficiency by using diffusion solutions in nodes where such a treatment is sufficient. The transport method is initially developed and coupled to the reformulated 3-D nodal diffusion model in the CYNOD code for PBR core design and fuel cycle analysis. This method is also extended to the prismatic VHTR. The new method accurately captures transport effects in highly heterogeneous regions with steep flux gradients. The calculations of these nodes with transport theory avoid errors associated with spatial homogenization commonly used in diffusion methods in reactor core simulators

  4. Models for the configuration and integrity of partially oxidized fuel rod cladding at high temperatures -- Final Design Report

    SciTech Connect (OSTI)

    Siefken, L.J.

    1999-01-01T23:59:59.000Z

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. The modeling was improved in five areas. First, the configuration defined for melted metallic cladding retained by an adjacent oxide layer was improved. Second, the empirical model to account for the effect on oxidation of intact cladding is not significantly reduced by the presence of a rather high concentration of relocated material. Third, models for the dissolution of the oxide layer by the metallic layer were implemented into the code. Fourth, a model was added to calculate the thermal stress applied to the oxide layer by the temperature gradient across the oxide layer and to compare this stress to the ultimate strength of the oxide layer. Fifth, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The assessment of these models and their integration into SCDAP/RELAP5 showed that the calculated axial distribution in cladding oxidation and relocation are in significantly better agreement with experimental results than is currently the case. The modeling changes account for three aspects of behavior that were not previously calculated correctly. The implementation of these models eliminates to a significant extent the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material.

  5. Models for the Configuration and Integrity of Partially Oxidized Fuel Rod Cladding at High Temperatures - Final Design Report

    SciTech Connect (OSTI)

    Siefken, Larry James

    1999-02-01T23:59:59.000Z

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. The modeling was improved in five areas. First, the configuration defined for melted metallic cladding retained by an adjacent oxide layer was improved. Second, the empirical model to account for the effect on oxidation of intact cladding is not significantly reduced by the presence of a rather high concentration of relocated material. Third, models for the dissolution of the oxide layer by the metallic layer were implemented into the code. Fourth, a model was added to calculate the thermal stress applied to the oxide layer by the temperature gradient across the oxide layer and to compare this stress to the ultimate strength of the oxide layer. Fifth, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The assessment of these models and their integration into SCDAP/RELAP5 showed that the calculated axial distribution in cladding oxidation and relocation are in significantly better agreement with experimental results than is currently the case. The modeling changes account for three aspects of behavior that were not previously calculated correctly. The implementation of these models eliminates to a significant extent the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material.

  6. Producing thin film photovoltaic modules with high integrity interconnects and dual layer contacts

    DOE Patents [OSTI]

    Jansen, Kai W. (Lawrenceville, NJ); Maley, Nagi (Exton, PA)

    2001-01-01T23:59:59.000Z

    High performance photovoltaic modules are produced with improved interconnects by a special process. Advantageously, the photovoltaic modules have a dual layer back (rear) contact and a front contact with at least one layer. The front contact and the inner layer of the back contact can comprise a transparent conductive oxide. The outer layer of the back contact can comprise a metal or metal oxide. The front contact can also have a dielectric layer. In one form, the dual layer back contact comprises a zinc oxide inner layer and an aluminum outer layer and the front contact comprises a tin oxide inner layer and a silicon dioxide dielectric outer layer. One or more amorphous silicon-containing thin film semiconductors can be deposited between the front and back contacts. The contacts can be positioned between a substrate and an optional superstrate. During production, the transparent conductive oxide layer of the front contact is scribed by a laser, then the amorphous silicon-containing semiconductors and inner layer of the dual layer back contact are simultaneously scribed and trenched (drilled) by the laser and the trench is subsequently filled with the same metal as the outer layer of the dual layer back contact to provide a superb mechanical and electrical interconnect between the front contact and the outer layer of the dual layer back contact. The outer layer of the dual layer back contact can then be scribed by the laser. For enhanced environmental protection, the photovoltaic modules can be encapsulated.

  7. Producing thin film photovoltaic modules with high integrity interconnects and dual layer contacts

    DOE Patents [OSTI]

    Jansen, Kai W. (Lawrenceville, NJ); Maley, Nagi (Exton, PA)

    2000-01-01T23:59:59.000Z

    High performance photovoltaic modules are produced with improved interconnects by a special process. Advantageously, the photovoltaic modules have a dual layer back (rear) contact and a front contact with at least one layer. The front contact and the inner layer of the back contact can comprise a transparent conductive oxide. The outer layer of the back contact can comprise a metal or metal oxide. The front contact can also have a dielectric layer. In one form, the dual layer back contact comprises a zinc oxide inner layer and an aluminum outer layer and the front contact comprises a tin oxide inner layer and a silicon dioxide dielectric outer layer. One or more amorphous silicon-containing thin film semiconductors can be deposited between the front and back contacts. The contacts can be positioned between a substrate and an optional superstrate. During production, the transparent conductive oxide layer of the front contact is scribed by a laser, then the amorphous silicon-containing semiconductors and inner layer of the dual layer back contact are simultaneously scribed and trenched (drilled) by the laser and the trench is subsequently filled with the same metal as the outer layer of the dual layer back contact to provide a superb mechanical and electrical interconnect between the front contact and the outer layer of the dual layer back contact. The outer layer of the dual layer back contact can then be scribed by the laser. For enhanced environmental protection, the photovoltaic modules can be encapsulated.

  8. High-efficiency grid-connected photovoltaic module integrated converter system with high-speed communication interfaces for small-scale distribution power generation

    SciTech Connect (OSTI)

    Choi, Woo-Young; Lai, Jih-Sheng (Jason) [Future Energy Electronics Center, Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA (United States)

    2010-04-15T23:59:59.000Z

    This paper presents a high-efficiency grid-connected photovoltaic (PV) module integrated converter (MIC) system with reduced PV current variation. The proposed PV MIC system consists of a high-efficiency step-up DC-DC converter and a single-phase full-bridge DC-AC inverter. An active-clamping flyback converter with a voltage-doubler rectifier is proposed for the step-up DC-DC converter. The proposed step-up DC-DC converter reduces the switching losses by eliminating the reverse-recovery current of the output rectifying diodes. To reduce the PV current variation introduced by the grid-connected inverter, a PV current variation reduction method is also suggested. The suggested PV current variation reduction method reduces the PV current variation without any additional components. Moreover, for centralized power control of distributed PV MIC systems, a PV power control scheme with both a central control level and a local control level is presented. The central PV power control level controls the whole power production by sending out reference power signals to each individual PV MIC system. The proposed step-up DC-DC converter achieves a high-efficiency of 97.5% at 260 W output power to generate the DC-link voltage of 350 V from the PV voltage of 36.1 V. The PV MIC system including the DC-DC converter and the DC-AC inverter achieves a high-efficiency of 95% with the PV current ripple less than 3% variation of the rated PV current. (author)

  9. Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs

    E-Print Network [OSTI]

    van der Mei, Rob

    Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs Sandjai The Netherlands Email: sbhulai@few.vu.nl Rob van der Mei a,b b CWI Advanced Communication Networks P.O. Box 94079@feweb.vu.nl Abstract-- The wireless LAN technology 802.11, also called Wi-Fi, offers high speed wireless Internet

  10. irm-EAMS routine measurements: high precision; high accuracy; high throughput

    E-Print Network [OSTI]

    Eurovector EA allows to exchange the reactors separately (and fast). Exchange of the Mg(ClO4)2 water traps and selective CO2 trapping; Improved halide robustness of the combustion reactor using CeO2., Rapid Comm. Mass) inside the EA are exchanged regularly. On the CE-EA, combustion and reduction reactors are always

  11. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of Blythe Solar PowerCommercial Cold Climate HeatEnergy

  12. In: Proceedings of the 2005 IEEE International Symposium on Workload Characterization (IISWC), October 2005, c IEEE Comprehensive Throughput Evaluation of LANs in Clusters of PCs

    E-Print Network [OSTI]

    characteristics of net- works for clusters. A first microbenchmark tests the basic pro- cessing limitations. A second microbenchmark tests arbitrary communication pat- terns by pairwise connecting nodes for high-speed throughput tests. A third and slightly more realistic microbenchmark ex- ecutes an all-to-all personalised

  13. Integration of a broad beam ion source with a high-temperature x-ray diffraction vacuum chamber

    SciTech Connect (OSTI)

    Manova, D.; Bergmann, A.; Maendl, S.; Neumann, H.; Rauschenbach, B. [Leibniz-Institut fuer Oberflaechenmodifizierung e. V., Permoserstr. 15, 04318 Leipzig (Germany)

    2012-11-15T23:59:59.000Z

    Here, the integration of a low energy, linearly variable ion beam current density, mechanically in situ adjustable broad beam ion source with a high-temperature x-ray diffraction (XRD) vacuum chamber is reported. This allows in situ XRD investigation of phase formation and evolution processes induced by low energy ion implantation. Special care has been taken to an independent adjustment of the ion beam for geometrical directing towards the substrate, a 15 mm small ion source exit aperture to avoid a secondary sputter process of the chamber walls, linearly variable ion current density by using a pulse length modulation (PLM) for the accelerating voltages without changing the ion beam density profile, nearly homogeneous ion beam distribution over the x-ray footprint, together with easily replaceable Kapton{sup Registered-Sign} windows for x-rays entry and exit. By combining a position sensitive x-ray detector with this PLM-modulated ion beam, a fast and efficient time resolved investigation of low energy implantation processes is obtained in a compact experimental setup.

  14. High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

    SciTech Connect (OSTI)

    Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B. [Mitre Corp., McLean, VA (United States)

    1995-06-01T23:59:59.000Z

    The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report.

  15. NREL Analysis: Cost-Effective and Reliable Integration of High-Penetration Solar in the Western United States (Poster)

    SciTech Connect (OSTI)

    Lew, D.; Brinkman, G.; Ibanez, E.; Hodge, B.; Lefton, S.; Kumar, N.; Agan, D.; Jordan, G.; Venkatataman, S.

    2012-07-01T23:59:59.000Z

    SunShot Initiative awardee posters describing the different technologies within the four subprograms of the DOE Solar Program (Photovoltaics, Concentrating Solar Power, Soft Costs, and Systems Integration).

  16. How Do High Levels of Wind and Solar Impact the Grid? The Western Wind and Solar Integration Study

    SciTech Connect (OSTI)

    Lew, D.; Piwko, D.; Miller, N.; Jordan, G.; Clark, K.; Freeman, L.

    2010-12-01T23:59:59.000Z

    This paper is a brief introduction to the scope of the Western Wind and Solar Integration Study (WWSIS), inputs and scenario development, and the key findings of the study.

  17. High Efficiency Integrated Space Conditioning, Water Heating and Air Distribution System for HUD-Code Manufactured Housing

    SciTech Connect (OSTI)

    Henry DeLima; Joe Akin; Joseph Pietsch

    2008-09-14T23:59:59.000Z

    Recognizing the need for new space conditioning and water heating systems for manufactured housing, DeLima Associates assembled a team to develop a space conditioning system that would enhance comfort conditions while also reducing energy usage at the systems level. The product, Comboflair® was defined as a result of a needs analysis of project sponsors and industry stakeholders. An integrated system would be developed that would combine a packaged airconditioning system with a small-duct, high-velocity air distribution system. In its basic configuration, the source for space heating would be a gas water heater. The complete system would be installed at the manufactured home factory and would require no site installation work at the homesite as is now required with conventional split-system air conditioners. Several prototypes were fabricated and tested before a field test unit was completed in October 2005. The Comboflair® system, complete with ductwork, was installed in a 1,984 square feet, double-wide manufactured home built by Palm Harbor Homes in Austin, TX. After the home was transported and installed at a Palm Harbor dealer lot in Austin, TX, a data acquisition system was installed for remote data collection. Over 60 parameters were continuously monitored and measurements were transmitted to a remote site every 15 minutes for performance analysis. The Comboflair® system was field tested from February 2006 until April 2007. The cooling system performed in accordance with the design specifications. The heating system initially could not provide the needed capacity at peak heating conditions until the water heater was replaced with a higher capacity standard water heater. All system comfort goals were then met. As a result of field testing, we have identified improvements to be made to specific components for incorporation into production models. The Comboflair® system will be manufactured by Unico, Inc. at their new production facility in St. Louis, MO. The product will be initially launched in the hot-humid climates of the southern U.S.

  18. SMOV3B WFPC2 UV Contamination Monitoring and Throughput Check

    E-Print Network [OSTI]

    Sirianni, Marco

    1 SMOV3B WFPC2 UV Contamination Monitoring and Throughput Check A. M. Koekemoer, S. Gonzaga, L is potentially susceptible to significant decreases as a result of contaminants deposited on the cold CCD windows intensive monitoring of this contamination using the F170W filter, to ensure that the throughput never

  19. Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based

    E-Print Network [OSTI]

    Rosenberg, Catherine P.

    1 Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based Interference crucial design objectives for a number of multihop wireless network applica- tions. As these two this tradeoff between the network throughput and lifetime, for the case of fixed wireless networks where link

  20. Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations

    E-Print Network [OSTI]

    Minnesota, University of

    Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell@ou.edu Abstract-- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links. This is very similar to processor performance degradation due to control hazards in CPU design. First, two

  1. China's Civil-Military Integration

    E-Print Network [OSTI]

    LAFFERTY, Brian; SHRABERG, Aaron; CLEMENS, Morgan

    2013-01-01T23:59:59.000Z

    China’s civil-military integration, and China’s high tech2013 China’s Civil-Military Integration Brian LAFFERTY Aarons pursuit of civil-military integration (CMI) intensified in

  2. Development of integrated thermionic circuits for high-temperature applications. [Operation to 500/sup 0/C ambient temperature

    SciTech Connect (OSTI)

    McCormick, J.B.; Wilde, D.; Depp, S.; Hamilton, D.J.; Kerwin, W.; Derouin, C.; Roybal, L.; Dooley, R.

    1981-01-01T23:59:59.000Z

    A class of devices known as integrated thermionic circuits (ITC) capable of extended operation in ambient temperatures up to 500/sup 0/C is described. The evolution of the ITC concept is discussed. A set of practical design and performance equations is demonstrated. Recent experimental results are discussed in which both devices and simple circuits have successfully operated in 500/sup 0/C environments for extended periods of time.

  3. High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells

    DOE Patents [OSTI]

    Daniel, Claus; Blue, Craig A.; Ott, Ronald D.

    2014-08-19T23:59:59.000Z

    Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.

  4. Screening for high-performance piezoelectrics using high-throughput density functional theory

    E-Print Network [OSTI]

    Armiento, Rickard R.

    We present a large-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal structure, with the aim of identifying those that are relevant for forming piezoelectric materials. ...

  5. High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets

    E-Print Network [OSTI]

    Wang, Benjamin L. (Benjamin Lu chen)

    2009-01-01T23:59:59.000Z

    Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...

  6. Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications

    E-Print Network [OSTI]

    Mao, Pan

    2009-01-01T23:59:59.000Z

    The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...

  7. Bayesian Model Selection for High-dimensional High-throughput Data

    E-Print Network [OSTI]

    Joshi, Adarsh

    2012-07-16T23:59:59.000Z

    LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi CHAPTER I INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II... BAYESIAN HYPOTHESIS TESTING USING TEST STATISTICS 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Bayes? factors based on test statistics: testing...

  8. ExperiBase : an integrated software architecture to support modern experimental biology

    E-Print Network [OSTI]

    Zhang, Shixin, 1970-

    2004-01-01T23:59:59.000Z

    Over the past several years, the explosive growth of biological data generated by new high-throughput instruments has virtually begun to drown the biological community. There is no established infrastructure to deal with ...

  9. The National High Magnetic Field Laboratory was represented by staff from its Center for Integrating Research and Learning

    E-Print Network [OSTI]

    McQuade, D. Tyler

    to drop a magnet seemingly in slow motion through a copper pipe. The USA Science and Engineering Festival and Engineering Festival National High Magnetic Field Laboratory Funding Grants: G.S. Boebinger (NSF DMR-1157490The National High Magnetic Field Laboratory was represented by staff from its Center

  10. Si-CMOS-Like Integration of AlGaN/GaN Dielectric-Gated High-Electron-Mobility Transistors

    E-Print Network [OSTI]

    Johnson, Derek Wade

    2014-07-31T23:59:59.000Z

    the engineering of high mobility, high carrier density channels at III-Nitride heterointerfaces. In order to seize market share from silicon, the cost of manufacturing GaN-based devices must be further reduced. With the successful realization of 200mm Ga...

  11. Si-CMOS-Like Integration of AlGaN/GaN Dielectric-Gated High-Electron-Mobility Transistors 

    E-Print Network [OSTI]

    Johnson, Derek Wade

    2014-07-31T23:59:59.000Z

    the engineering of high mobility, high carrier density channels at III-Nitride heterointerfaces. In order to seize market share from silicon, the cost of manufacturing GaN-based devices must be further reduced. With the successful realization of 200mm Ga...

  12. Potential Impact of Interfacial Bonding Efficiency on High-Burnup Spent Nuclear Fuel Vibration Integrity during Normal Transportation

    SciTech Connect (OSTI)

    Jiang, Hao [ORNL; Wang, Jy-An John [ORNL; Wang, Hong [ORNL

    2014-01-01T23:59:59.000Z

    Finite element analysis (FEA) was used to investigate the impacts of interfacial bonding efficiency at pellet pellet and pellet clad interfaces on spent nuclear fuel (SNF) vibration integrity. The FEA simulation results were also validated and benchmarked with reverse bending fatigue test results on surrogate rods consisting of stainless steel (SS) tubes with alumina-pellet inserts. Bending moments (M) are applied to the FEA models to evaluate the system responses of the surrogate rods. From the induced curvature, , the flexural rigidity EI can be estimated as EI=M/ . The impacts of interfacial bonding efficiency on SNF vibration integrity include the moment carrying capacity distribution between pellets and clad and the impact of cohesion on the flexural rigidity of the surrogate rod system. The result also indicates that the immediate consequences of interfacial de-bonding are a load carrying capacity shift from the fuel pellets to the clad and a reduction of the composite rod flexural rigidity. Therefore, the flexural rigidity of the surrogate rod and the bending moment bearing capacity between the clad and fuel pellets are strongly dependent on the efficiency of interfacial bonding at the pellet pellet and pellet clad interfaces. The above-noted phenomenon was calibrated and validated by reverse bending fatigue testing using a surrogate rod system.

  13. Low-temperature germanium ultra-high vacuum chemical vapor deposition for back-end photonic integration

    E-Print Network [OSTI]

    Kimerling, Lionel C.

    Polycrystalline germanium (poly-Ge) grown on amorphous Si (a-Si) by ultra-high vacuum chemical vapor deposition (UHVCVD) over oxide barriers at low temperatures (Tles450degC) exhibits a larger grain size and lower defect ...

  14. Efficient Nanoporous Silicon Membranes for Integrated Microfluidic Separation and Sensing Systems

    SciTech Connect (OSTI)

    Ileri, N; L?tant, S E; Britten, J; Nguyen, H; Larson, C; Zaidi, S; Palazoglu, A; Faller, R; Tringe, J W; Stroeve, P

    2009-04-06T23:59:59.000Z

    Nanoporous devices constitute emerging platforms for selective molecule separation and sensing, with great potential for high throughput and economy in manufacturing and operation. Acting as mass transfer diodes similar to a solid-state device based on electron conduction, conical pores are shown to have superior performance characteristics compared to traditional cylindrical pores. Such phenomena, however, remain to be exploited for molecular separation. Here we present performance results from silicon membranes created by a new synthesis technique based on interferometric lithography. This method creates millimeter sized planar arrays of uniformly tapered nanopores in silicon with pore diameter 100 nm or smaller, ideally-suited for integration into a multi-scale microfluidic processing system. Molecular transport properties of these devices are compared against state-of-the-art polycarbonate track etched (PCTE) membranes. Mass transfer rates of up to fifteen-fold greater than commercial sieve technology are obtained. Complementary results from molecular dynamics simulations on molecular transport are reported.

  15. Throughput Optimal Scheduling in the Presence of Heavy-Tailed Traffic

    E-Print Network [OSTI]

    Jagannathan, Krishna Prasanna

    We investigate the tail behavior of the steady-state queue occupancies under throughput optimal scheduling in the presence of heavy-tailed traffic. We consider a system consisting of two parallel queues, served by a single ...

  16. Development of an Integrated Raman and Turbidity Fiber Optic Sensor for the In-Situ Analysis of High Level Nuclear Waste - 13532

    SciTech Connect (OSTI)

    Gasbarro, Christina; Bello, Job [EIC Laboratories, Inc., 111 Downey St., Norwood, MA, 02062 (United States)] [EIC Laboratories, Inc., 111 Downey St., Norwood, MA, 02062 (United States); Bryan, Samuel; Lines, Amanda; Levitskaia, Tatiana [Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352 (United States)] [Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352 (United States)

    2013-07-01T23:59:59.000Z

    Stored nuclear waste must be retrieved from storage, treated, separated into low- and high-level waste streams, and finally put into a disposal form that effectively encapsulates the waste and isolates it from the environment for a long period of time. Before waste retrieval can be done, waste composition needs to be characterized so that proper safety precautions can be implemented during the retrieval process. In addition, there is a need for active monitoring of the dynamic chemistry of the waste during storage since the waste composition can become highly corrosive. This work describes the development of a novel, integrated fiber optic Raman and light scattering probe for in situ use in nuclear waste solutions. The dual Raman and turbidity sensor provides simultaneous chemical identification of nuclear waste as well as information concerning the suspended particles in the waste using a common laser excitation source. (authors)

  17. Development of an Integrated Raman and Turbidity Fiber Optic Sensor for the In-Situ Analysis of High Level Nuclear Waste

    SciTech Connect (OSTI)

    Gasbarro, Christina; Bello, Job M.; Bryan, Samuel A.; Lines, Amanda M.; Levitskaia, Tatiana G.

    2013-02-24T23:59:59.000Z

    Stored nuclear waste must be retrieved from storage, treated, separated into low- and high-level waste streams, and finally put into a disposal form that effectively encapsulates the waste and isolates it from the environment for a long period of time. Before waste retrieval can be done, waste composition needs to be characterized so that proper safety precautions can be implemented during the retrieval process. In addition, there is a need for active monitoring of the dynamic chemistry of the waste during storage since the waste composition can become highly corrosive. This work describes the development of a novel, integrated fiber optic Raman and light scattering probe for in situ use in nuclear waste solutions. The dual Raman and turbidity sensor provides simultaneous chemical identification of nuclear waste as well as information concerning the suspended particles in the waste using a common laser excitation source.

  18. A new 3D parallel high resolution electromagnetic nonlinear inversion based on new global magnetic integral and local differential decomposition (GILD)

    SciTech Connect (OSTI)

    Xie, G.; Li, J. [Lawrence Berkeley National Lab., CA (United States). Earth Sciences Div.

    1997-05-01T23:59:59.000Z

    A new 3D electromagnetic modeling and nonlinear inversion algorithm is presented based on global integral and local differential equations decomposition (GILD). The GILD parallel nonlinear inversion algorithm consists of five parts: (1) the domain is decomposed into subdomain SI and subdomain SII; (2) a new global magnetic integral equation in SI and the local magnetic differential equations IN SII will be used together to obtain the magnetic field in the modeling step; (3) the new global magnetic integral Jacobian equation in SI and the local magnetic differential Jacobian equations in SII will be used together to update the electric conductivity and permittivity from the magnetic field data in the inversion step; (4) the subdomain SII can naturally and uniformly be decomposed into 2{sup n} smaller sub-cubic-domains; the sparse matrix in each sub-cubic-domain can be eliminated separately, in parallel; (5) a new parallel multiple hierarchy substructure algorithm will be used to solve the smaller full matrices in SI, in parallel. The applications of the new 3D parallel GILD EM modeling and nonlinear inversion algorithm and software are: (1) to create high resolution controlled-source electric conductivity and permittivity imaging for interpreting electromagnetic field data acquired from cross hole, surface to borehole, surface to surface, single hole, and multiple holes; (2) to create the magnetotelluric high resolution imaging from the surface impedance and field data. The new GILD parallel nonlinear inversion will be a 3D/2.5D powerful imaging tool for the oil geophysical exploration and environmental remediation and monitoring.

  19. Thickness effects on fracture toughness of ultra-high-molecular- weight polyethylene via the J-integral

    E-Print Network [OSTI]

    Lehmann, Jarvis Craig

    1992-01-01T23:59:59.000Z

    of different thickness 1T compact tension specimens with the same initial crack length were tested using ASTM E 813-87 multiple specimen methodology as a guide. Six J-R curves were produced corresponding to the mean thickness of each specimen set; mean...'s decreasing toughness behavior with increasing thickness. UHMW-PE was found to have a tearing resistance, J-R curve, which increases with specimen thickness and crack growth and comparable to tough, high tearing resistant steels. This high tearing...

  20. The INTEGRAL - HESS/MAGIC connection: a new class of cosmic high energy accelerators from keV to TeV

    E-Print Network [OSTI]

    Pietro Ubertini

    2006-05-09T23:59:59.000Z

    The recent completion and operation of the High Energy Stereoscopic System, an array of ground based imaging Cherenkov telescopes, has provided a survey with unprecedented sensitivity of the inner part of the Galaxy and revealed a new population of very high energy gamma-rays sources emitting at E$>$100 GeV. Most of them were reported to have no known radio or X-ray counterpart and hypothesised to be representative of a new class of dark nucleonic cosmic sources. In fact, very high energy gamma-rays with energies E $>$ 10$^{11}$ eV are the best proof of non-thermal processes in the universe and provide a direct in-site view of matter-radiation interaction at energies by far greater than producible in ground accelerators. At lower energy INTEGRAL has regularly observed the entire galactic plane during the first 1000 day in orbit providing a survey in the 20-100 keV range resulted in a soft gamma-ray sky populated with more than 200 sources, most of them being galactic binaries, either BHC or NS. Very recently, the INTEGRAL new source IGR J18135-1751 has been identified as the soft gamma-ray counterpart of HESS J1813-178 and AXJ1838.0-0655 as the X/gamma-ray counterpart of HESS J1837-069. Detection of non thermal radio, X and gamma-ray emission from these TeV sources is very important to discriminate between various emitting scenarios and, in turn, to fully understand their nature. The implications of these new findings in the high energy Galactic population will be addressed.

  1. Marine High Voltage Power Conditioning and Transmission System with Integrated Storage DE-EE0003640 Final Report

    SciTech Connect (OSTI)

    Frank Hoffmann, PhD; Aspinall, Rik

    2012-12-10T23:59:59.000Z

    Design, Development, and test of the three-port power converter for marine hydrokinetic power transmission. Converter provides ports for AC/DC conversion of hydrokinetic power, battery storage, and a low voltage to high voltage DC port for HVDC transmission to shore. The report covers the design, development, implementation, and testing of a prototype built by PPS.

  2. Design and Control of High Temperature PEM Fuel Cell Systems using Methanol Reformers with Air or Liquid Heat Integration

    E-Print Network [OSTI]

    Berning, Torsten

    of burner temperature and the aspects of implementing advanced modeling based control approaches using], auxiliary and uninterruptible power systems [13, 14, 15, 16, 17, 18, 19]. Polymer electrolyte membrane fuelDesign and Control of High Temperature PEM Fuel Cell Systems using Methanol Reformers with Air

  3. Integrated Operation of INL HYTEST System and High-Temperature Steam Electrolysis for Synthetic Natural Gas Production

    SciTech Connect (OSTI)

    Carl Marcel Stoots; Lee Shunn; James O'Brien

    2010-06-01T23:59:59.000Z

    The primary feedstock for synthetic fuel production is syngas, a mixture of carbon monoxide and hydrogen. Current hydrogen production technologies rely upon fossil fuels and produce significant quantities of greenhouse gases as a byproduct. This is not a sustainable means of satisfying future hydrogen demands, given the current projections for conventional world oil production and future targets for carbon emissions. For the past six years, the Idaho National Laboratory has been investigating the use of high-temperature steam electrolysis (HTSE) to produce the hydrogen feedstock required for synthetic fuel production. High-temperature electrolysis water-splitting technology, combined with non-carbon-emitting energy sources, can provide a sustainable, environmentally-friendly means of large-scale hydrogen production. Additionally, laboratory facilities are being developed at the INL for testing hybrid energy systems composed of several tightly-coupled chemical processes (HYTEST program). The first such test involved the coupling of HTSE, CO2 separation membrane, reverse shift reaction, and methanation reaction to demonstrate synthetic natural gas production from a feedstock of water and either CO or a simulated flue gas containing CO2. This paper will introduce the initial HTSE and HYTEST testing facilities, overall coupling of the technologies, testing results, and future plans.

  4. Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC) : gap analysis for high fidelity and performance assessment code development.

    SciTech Connect (OSTI)

    Lee, Joon H.; Siegel, Malcolm Dean; Arguello, Jose Guadalupe, Jr.; Webb, Stephen Walter; Dewers, Thomas A.; Mariner, Paul E.; Edwards, Harold Carter; Fuller, Timothy J.; Freeze, Geoffrey A.; Jove-Colon, Carlos F.; Wang, Yifeng

    2011-03-01T23:59:59.000Z

    This report describes a gap analysis performed in the process of developing the Waste Integrated Performance and Safety Codes (IPSC) in support of the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The goal of the Waste IPSC is to develop an integrated suite of computational modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with rigorous verification, validation, and software quality requirements. The gap analyses documented in this report were are performed during an initial gap analysis to identify candidate codes and tools to support the development and integration of the Waste IPSC, and during follow-on activities that delved into more detailed assessments of the various codes that were acquired, studied, and tested. The current Waste IPSC strategy is to acquire and integrate the necessary Waste IPSC capabilities wherever feasible, and develop only those capabilities that cannot be acquired or suitably integrated, verified, or validated. The gap analysis indicates that significant capabilities may already exist in the existing THC codes although there is no single code able to fully account for all physical and chemical processes involved in a waste disposal system. Large gaps exist in modeling chemical processes and their couplings with other processes. The coupling of chemical processes with flow transport and mechanical deformation remains challenging. The data for extreme environments (e.g., for elevated temperature and high ionic strength media) that are needed for repository modeling are severely lacking. In addition, most of existing reactive transport codes were developed for non-radioactive contaminants, and they need to be adapted to account for radionuclide decay and in-growth. The accessibility to the source codes is generally limited. Because the problems of interest for the Waste IPSC are likely to result in relatively large computational models, a compact memory-usage footprint and a fast/robust solution procedure will be needed. A robust massively parallel processing (MPP) capability will also be required to provide reasonable turnaround times on the analyses that will be performed with the code. A performance assessment (PA) calculation for a waste disposal system generally requires a large number (hundreds to thousands) of model simulations to quantify the effect of model parameter uncertainties on the predicted repository performance. A set of codes for a PA calculation must be sufficiently robust and fast in terms of code execution. A PA system as a whole must be able to provide multiple alternative models for a specific set of physical/chemical processes, so that the users can choose various levels of modeling complexity based on their modeling needs. This requires PA codes, preferably, to be highly modularized. Most of the existing codes have difficulties meeting these requirements. Based on the gap analysis results, we have made the following recommendations for the code selection and code development for the NEAMS waste IPSC: (1) build fully coupled high-fidelity THCMBR codes using the existing SIERRA codes (e.g., ARIA and ADAGIO) and platform, (2) use DAKOTA to build an enhanced performance assessment system (EPAS), and build a modular code architecture and key code modules for performance assessments. The key chemical calculation modules will be built by expanding the existing CANTERA capabilities as well as by extracting useful components from other existing codes.

  5. High Througput Combinatorial Techniques in Hydrogen Storage Materials...

    Broader source: Energy.gov (indexed) [DOE]

    and surface area measurements (high-throughput techniques need development). 5. Aerogels Page 2 of 5 Synthesis is based on standard sol-gel processes and should be similar to...

  6. 21T High Resolution Mass Accuracy Capability | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mass analyzer with co-located capabilities in high - throughput omics, imaging, and microfluidics. The 21T FTICR MS will be the best, if not the only, capability in the world to...

  7. A Service Oriented Architecture for Exploring High Performance Distributed Power Models

    SciTech Connect (OSTI)

    Liu, Yan; Chase, Jared M.; Gorton, Ian

    2012-11-12T23:59:59.000Z

    Power grids are increasingly incorporating high quality, high throughput sensor devices inside power distribution networks. These devices are driving an unprecedented increase in the volume and rate of available information. The real-time requirements for handling this data are beyond the capacity of conventional power models running in central utilities. Hence, we are exploring distributed power models deployed at the regional scale. The connection of these models for a larger geographic region is supported by a distributed system architecture. This architecture is built in a service oriented style, whereby distributed power models running on high performance clusters are exposed as services. Each service is semantically annotated and therefore can be discovered through a service catalog and composed into workflows. The overall architecture has been implemented as an integrated workflow environment useful for power researchers to explore newly developed distributed power models.

  8. A Deeply Pipelined CABAC Decoder for HEVC Supporting Level 6.2 High-tier Applications

    E-Print Network [OSTI]

    Chen, Yu-Hsin

    High Efficiency Video Coding (HEVC) is the latest video coding standard that specifies video resolutions up to 8K Ultra-HD (UHD) at 120 fps to support the next decade of video applications. This results in high-throughput ...

  9. A compression scheme for radio data in high performance computing

    E-Print Network [OSTI]

    Masui, Kiyoshi; Connor, Liam; Deng, Meiling; Fandino, Mateus; Höfer, Carolin; Halpern, Mark; Hanna, David; Hincks, Adam D; Hinshaw, Gary; Parra, Juan Mena; Newburgh, Laura B; Shaw, J Richard; Vanderlinde, Keith

    2015-01-01T23:59:59.000Z

    We present a procedure for efficiently compressing astronomical radio data for high performance applications. Integrated, post-correlation data are first passed through a nearly lossless rounding step which compares the precision of the data to a generalized and calibration-independent form of the radiometer equation. This allows the precision of the data to be reduced in a way that has an insignificant impact on the data. The newly developed Bitshuffle lossless compression algorithm is subsequently applied. When the algorithm is used in conjunction with the HDF5 library and data format, data produced by the CHIME Pathfinder telescope is compressed to 28% of its original size and decompression throughputs in excess of 1 GB/s are obtained on a single core.

  10. Compact electro-absorption modulator integrated with vertical-cavity surface-emitting laser for highly efficient millimeter-wave modulation

    SciTech Connect (OSTI)

    Dalir, Hamed, E-mail: dalir.h.ac@m.titech.ac.jp [Precision and Intelligence Laboratory, Photonics Integration System Research Center, Tokyo Institute of Technology, 4259-R2-22 Nagatsuta-cho, Midori-ku, Yokohama, 226-8503 (Japan); Ahmed, Moustafa; Bakry, Ahmed [Department of Physics, Faculty of Science, King Abdulaziz University, 80203 Jeddah 21589 (Saudi Arabia); Koyama, Fumio [Precision and Intelligence Laboratory, Photonics Integration System Research Center, Tokyo Institute of Technology, 4259-R2-22 Nagatsuta-cho, Midori-ku, Yokohama, 226-8503 (Japan); Department of Physics, Faculty of Science, King Abdulaziz University, 80203 Jeddah 21589 (Saudi Arabia)

    2014-08-25T23:59:59.000Z

    We demonstrate a compact electro-absorption slow-light modulator laterally-integrated with an 850?nm vertical-cavity surface-emitting laser (VCSEL), which enables highly efficient millimeter-wave modulation. We found a strong leaky travelling wave in the lateral direction between the two cavities via widening the waveguide width with a taper shape. The small signal response of the fabricated device shows a large enhancement of over 55?dB in the modulation amplitude at frequencies beyond 35 GHz; thanks to the photon-photon resonance. A large group index of over 150 in a Bragg reflector waveguide enables the resonance at millimeter wave frequencies for 25 ?m long compact modulator. Based on the modeling, we expect a resonant modulation at a higher frequency of 70 GHz. The resonant modulation in a compact slow-light modulator plays a significant key role for high efficient narrow-band modulation in the millimeter wave range far beyond the intrinsic modulation bandwidth of VCSELs.

  11. Cluster Computing: High-Performance, High-Availability, and High-Throughput Processing on a Network of Computers

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Laboratory Dept. of Computer Science and Software Engineering The University of Melbourne, Australia {csyeo, raj}@cs.mu.oz.au 2 Parallel and Distributed Systems Laboratory Department of Computer Science for cluster computing was developed in the 1960s by IBM as an alternative of linking large mainframes

  12. Integration of first-principles methods and crystallographic database searches for new ferroelectrics: Strategies and explorations

    SciTech Connect (OSTI)

    Bennett, Joseph W. [Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08854 (United States)] [Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08854 (United States); Rabe, Karin M., E-mail: rabe@physics.rutgers.edu [Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08854 (United States)

    2012-11-15T23:59:59.000Z

    In this concept paper, the development of strategies for the integration of first-principles methods with crystallographic database mining for the discovery and design of novel ferroelectric materials is discussed, drawing on the results and experience derived from exploratory investigations on three different systems: (1) the double perovskite Sr(Sb{sub 1/2}Mn{sub 1/2})O{sub 3} as a candidate semiconducting ferroelectric; (2) polar derivatives of schafarzikite MSb{sub 2}O{sub 4}; and (3) ferroelectric semiconductors with formula M{sub 2}P{sub 2}(S,Se){sub 6}. A variety of avenues for further research and investigation are suggested, including automated structure type classification, low-symmetry improper ferroelectrics, and high-throughput first-principles searches for additional representatives of structural families with desirable functional properties. - Graphical abstract: Integration of first-principles methods with crystallographic database mining, for the discovery and design of novel ferroelectric materials, could potentially lead to new classes of multifunctional materials. Highlights: Black-Right-Pointing-Pointer Integration of first-principles methods and database mining. Black-Right-Pointing-Pointer Minor structural families with desirable functional properties. Black-Right-Pointing-Pointer Survey of polar entries in the Inorganic Crystal Structural Database.

  13. 2005 International Conference on Wireless Networks, Communications and Mobile Computing Improving TCP Throughput over Lossy Links Using

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell Labs 3660- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links is mainly due to processor performance degradation due to control hazards in CPU design. First, two types of loss events

  14. Grid Integration

    SciTech Connect (OSTI)

    Not Available

    2008-09-01T23:59:59.000Z

    Summarizes the goals and activities of the DOE Solar Energy Technologies Program efforts within its grid integration subprogram.

  15. High-? Al{sub 2}O{sub 3} material in low temperature wafer-level bonding for 3D integration application

    SciTech Connect (OSTI)

    Fan, J., E-mail: fanji@hust.edu.cn; Tu, L. C. [MOE Key Laboratory of Fundamental Physical Quantities Measurement, School of Physics, Huazhong University of Science and Technology, Wuhan 430074 (China)] [MOE Key Laboratory of Fundamental Physical Quantities Measurement, School of Physics, Huazhong University of Science and Technology, Wuhan 430074 (China); Tan, C. S. [School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore)] [School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore)

    2014-03-15T23:59:59.000Z

    This work systematically investigated a high-? Al{sub 2}O{sub 3} material for low temperature wafer-level bonding for potential applications in 3D microsystems. A clean Si wafer with an Al{sub 2}O{sub 3} layer thickness of 50 nm was applied as our experimental approach. Bonding was initiated in a clean room ambient after surface activation, followed by annealing under inert ambient conditions at 300?°C for 3 h. The investigation consisted of three parts: a mechanical support study using the four-point bending method, hermeticity measurements using the helium bomb test, and thermal conductivity analysis for potential heterogeneous bonding. Compared with samples bonded using a conventional oxide bonding material (SiO{sub 2}), a higher interfacial adhesion energy (?11.93 J/m{sup 2}) and a lower helium leak rate (?6.84 × 10{sup ?10} atm.cm{sup 3}/sec) were detected for samples bonded using Al{sub 2}O{sub 3}. More importantly, due to the excellent thermal conductivity performance of Al{sub 2}O{sub 3}, this technology can be used in heterogeneous direct bonding, which has potential applications for enhancing the performance of Si photonic integrated devices.

  16. Toxicity Assessment of Pelvic Intensity-Modulated Radiotherapy With Hypofractionated Simultaneous Integrated Boost to Prostate for Intermediate- and High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    McCammon, Robert; Rusthoven, Kyle E.; Kavanagh, Brian; Newell, Sherri B.S.; Newman, Francis M.S. [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Raben, David [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States)], E-mail: david.raben@uchsc.edu

    2009-10-01T23:59:59.000Z

    Purpose: To evaluate the toxicity of pelvic intensity-modulated radiotherapy (IMRT) with hypofractionated simultaneous integrated boost (SIB) to the prostate for patients with intermediate- to high-risk prostate cancer. Methods and Materials: A retrospective toxicity analysis was performed in 30 consecutive patients treated definitively with pelvic SIB-IMRT, all of whom also received androgen suppression. The IMRT plans were designed to deliver 70 Gy in 28 fractions (2.5 Gy/fraction) to the prostate while simultaneously delivering 50.4 Gy in 28 fractions (1.8 Gy/fraction) to the pelvic lymph nodes. The National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0, was used to score toxicity. Results: The most common acute Grade 2 events were cystitis (36.7%) and urinary frequency/urgency (26.7%). At a median follow-up of 24 months, late toxicity exceeding Grade 2 in severity was uncommon, with two Grade 3 events and one Grade 4 event. Grade 2 or greater acute bowel toxicity was associated with signficantly greater bowel volume receiving {>=}25 Gy (p = .04); Grade 2 or greater late bowel toxicity was associated with a higher bowel maximal dose (p = .04) and volume receiving {>=}50 Gy (p = .02). Acute or late bladder and rectal toxicity did not correlate with any of the dosimetric parameters examined. Conclusion: Pelvic IMRT with SIB to the prostate was well tolerated in this series, with low rates of Grade 3 or greater acute and late toxicity. SIB-IMRT combines pelvic radiotherapy and hypofractionation to the primary site and offers an accelerated approach to treating intermediate- to high-risk disease. Additional follow-up is necessary to fully define the long-term toxicity after hypofractionated, whole pelvic treatment combined with androgen suppression.

  17. Route Throughput Analysis with Spectral Reuse for Multi-Rate Mobile Ad Hoc Networks

    E-Print Network [OSTI]

    Tseng, Yu-Chee

    networks (MANETs) have received a lot of attention for its flexible network architecture. While many network (MANET) is a flexible and dynamic architecture that is attractive due to its ease in network1 Route Throughput Analysis with Spectral Reuse for Multi-Rate Mobile Ad Hoc Networks Lien-Wu Chen

  18. Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization

    E-Print Network [OSTI]

    Huang, Jianwei

    Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization Liqun Fu--This paper concerns the problem of finding the minimum-length TDMA frame of a power-controlled wire- less formulate the general joint link scheduling and power control problem as an in- teger linear programming

  19. Throughput Optimization in Multi-hop Wireless Networks with Multi-packet Reception and

    E-Print Network [OSTI]

    Jayaweera, Sudharman K.

    Mexico College, Espanola, NM - USA Electrical & Computer Engineering Dept., University of New Mexico layer have enabled the simultaneous reception of multiple packets by a node in wireless net- works. We model for the throughput optimization in MPR-capable wireless net- works, where nodes have one or more

  20. Accounting for Memory Use, Cost, Throughput, and Latency in the Design of a Media Server

    E-Print Network [OSTI]

    Chang, Edward Y.

    : the per­stream costs and the worst­case initial latency before a new media request can be satisfied. WeAccounting for Memory Use, Cost, Throughput, and Latency in the Design of a Media Server Edward scheduling and data place­ ment ones. We show that, some disk latency reduction techniques can

  1. SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS

    E-Print Network [OSTI]

    Simunic, Tajana

    SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS Edoardo Regini, Daeseob Diego La Jolla, CA 92093 {eregini, dalim, tajana}@ucsd.edu ABSTRACT Maximizing battery lifetime. This is because in heavy traffic conditions, the chance of nodes to successfully transmit a packet decreases

  2. Throughput Validation of an Advanced Channel Assignment Algorithm in IEEE 802.11 Mohamad Haidar

    E-Print Network [OSTI]

    Akl, Robert

    assignment for hot-spot service areas in a WLAN by formulating an Integer Linear Programming (ILP) modelThroughput Validation of an Advanced Channel Assignment Algorithm in IEEE 802.11 WLAN Mohamad channel-assignment algorithm at the Access Points (APs) of a Wireless Local Area Network (WLAN

  3. Effect of Height (Fresnel Clearance) on Signal Strength and Throughput for

    E-Print Network [OSTI]

    Liblit, Ben

    Effect of Height (Fresnel Clearance) on Signal Strength and Throughput for Medium and Long Distance obstruction height · Ignoring Fresnel Clearance For 20Km long Wireless Link, Fresnel Clearance requires around, height 4 m at Q ensures 100% Fresnel Clearance On Physical Inspection: No LOS even at 8 meters Distance

  4. Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption

    E-Print Network [OSTI]

    Hou, Y. Thomas

    Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption Canming: {jcm, yshi, thou, wjlou}@vt.edu Abstract Conserving network-wide energy consumption is becoming of wireless networks, the concern of energy consumption is becoming in- creasingly important for network

  5. Evolution integrals

    E-Print Network [OSTI]

    Rocco Duvenhage

    2006-05-24T23:59:59.000Z

    A framework analogous to path integrals in quantum physics is set up for abstract dynamical systems in a W*-algebraic setting. We consider spaces of evolutions, defined in a specific way, of a W*-algebra A as an analogue of spaces of classical paths, and show how integrals over such spaces, which we call ``evolution integrals'', lead to dynamics in a Hilbert space on a ``higher level'' which is viewed as an analogue of quantum dynamics obtained from path integrals. The measures with respect to which these integrals are performed are projection valued.

  6. Atomic-Layer-Deposited High-k Dielectric Integration on Epitaxial Graphene P.D. Ye, A.T. Neal, T. Shen, J.J. Gu, M.L. Bolen, and M. A. Capano

    E-Print Network [OSTI]

    Ye, Peide "Peter"

    for suspended CNT and graphene. There are three main preparation strategies for graphene, resulting in differentAtomic-Layer-Deposited High-k Dielectric Integration on Epitaxial Graphene P.D. Ye, A.T. Neal, T, III-V semiconductors, carbon nanotubes (CNTs) and graphene. Perfect top-gate dielectric stacks

  7. Flow-Through Microfluidic Device for High-Efficiency Transfection of Mammalian Cells through Combined Microelectroporation and Sonoporation

    E-Print Network [OSTI]

    Longsine, Whitney Leigh

    2012-07-16T23:59:59.000Z

    In this study we are presenting a proof-of-concept microfluidic device that simultaneously applies the conditions required for microelectroporation and micro-sonoporation in a flow-through fashion that allows for high throughput, high efficiency...

  8. Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center

    E-Print Network [OSTI]

    Vokoun, Matthew R. (Matthew Richard)

    2005-01-01T23:59:59.000Z

    The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...

  9. ComparativeComparative InteractomicsInteractomics comparative genomics of high throughput data

    E-Print Network [OSTI]

    Utrecht, Universiteit

    of quality of expert curation (to use as source or reference) and most prolific HTP data (complex mean absence of co- complex membership #12;Estimating absence of interactions from HTP dataEstimating absence of interactions from HTP data --> yeast; what do we call an absence of interaction data> yeast

  10. Real Time Pulse Pile-up Recovery in a High Throughput Digital Pulse Processor

    SciTech Connect (OSTI)

    Scoullar, Paul A. B.; McLean, Chris C. [Southern Innovation, Melbourne (Australia); Evans, Rob J. [Department of Electrical and Electronic Engineering, University of Melbourne (Australia)

    2011-12-13T23:59:59.000Z

    Detection and measurement of radiation is used extensively for non-invasive material characterization in a range of industries. However, many practical applications are frustrated by pulse pile-up within the detector. Pulse pile-up, which occurs when multiple radiation events arrive within the temporal resolving time of the detector, degrades the fidelity of subsequent material analysis. Traditional pulse processing techniques use fast digital filters and logic circuits to detect piled-up events and discard the corrupted data, however, this leads to substantial detector dead time. Consequently, there is considerable interest in more complex signal-processing algorithms to extend the performance of pulse processors and improve material characterization techniques. We present a technology for real-time decoding of pulse pile-up events. It is a model-based signal-processing algorithm able to accurately characterize the number, time-of-arrival and energy of all events in the detector output. Even in the presence of severe multi-pulse pile-up, the composite events are decoded and the energy and time-of-arrival recovered. The technology has been evaluated using a range of detectors, sources and count rates. An exceptional improvement over traditional pulse processing techniques is demonstrated.

  11. High-throughput screening of shape memory alloy thin-film spreads using nanoindentation

    E-Print Network [OSTI]

    Rubloff, Gary W.

    -film libraries. Nanoindentation was performed on Ni­Mn­Al ternary composition spreads. The indentation hardness and Wyrobek3 recently set forth a series of guidelines for the use of a nanoindenter to screen combina- torial

  12. High-Throughput Automated Luminescent Magnetic Particle-Based Immunoassay to Monitor

    E-Print Network [OSTI]

    Hammock, Bruce D.

    immunoassay de- scribed here is sensitive, simple to use, and more rapid than the previously reported standard significantly reduce the time and labor required for chromato- graphic separation and detection of multiple

  13. Examination of mammalian microRNAs by high-throughput sequencing

    E-Print Network [OSTI]

    Chiang, HyoJin Rosaria

    2011-01-01T23:59:59.000Z

    Small non-coding RNAs play an important role in a wide range of cellular events. MicroRNAs (miRNAs) are an abundant class of small RNAs that post-transcriptionally repress expression of their target genes. Since miRNA ...

  14. Development of a high throughput 3D perfused liver tissue bioreactor

    E-Print Network [OSTI]

    Inman, Samuel Walker

    2006-01-01T23:59:59.000Z

    This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...

  15. Geochip: A high throughput genomic tool for linking community structure to functions

    E-Print Network [OSTI]

    Van Nostrand, Joy D.

    2009-01-01T23:59:59.000Z

    soil samples from two oilfields, Daqing and Shengli, locatedall samples from the Daqing oilfield grouping together whilecommunity from the Shengli oilfield was separate (Figure 2),

  16. Database Requirements for Workflow Management in a HighThroughput Genome Laboratory 1

    E-Print Network [OSTI]

    Bonner, Anthony

    @genome.wi.mit.edu 2 University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S constitutes an audit trail, or event history, and has much the same function as a laboratory notebook number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. 1 #12

  17. LabFlow1: a Database Benchmark for HighThroughput Workflow Management ?

    E-Print Network [OSTI]

    Bonner, Anthony

    @db.toronto.edu Adel Shrufi 1 shrufi@db.toronto.edu Steve Rozen 2 steve@genome.wi.mit.edu 1 University of Toronto of workflow activity. This DBMS maintains an audit trail, or event history, that records the results of each Genome Research, grant number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02

  18. LabFlow1: a Database Benchmark for HighThroughput Workflow Management \\Lambda

    E-Print Network [OSTI]

    Bonner, Anthony

    University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S 1A4 2 track of workflow activity. This DBMS maintains an audit trail, or event history, that records number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. #12

  19. High-throughput approaches to sourcing of human hepatocytes for cell-based therapies

    E-Print Network [OSTI]

    Shan, Jing (Jing Meghan)

    2014-01-01T23:59:59.000Z

    Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...

  20. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  1. Ultra-high Throughput Real-time Instruments for Capturing Fast Signals and Rare Events

    E-Print Network [OSTI]

    Buckley, Brandon Walter

    2013-01-01T23:59:59.000Z

    from non-linear regression. . . . . . . . . . Conceptually,was estimated from non-linear regression. Un-Equalized RealRF band- width. A non-linear regression estimated the chirp

  2. Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening

    SciTech Connect (OSTI)

    Xu, Hongbo; Chen, Xiaohong; Huang, Junwei [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Deng, Weiwei [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China)] [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Zhong, Qi [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Yue, Changli [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China)] [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China); Wang, Pingzhang, E-mail: wangpzh@bjmu.edu.cn [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China) [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China); Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Huang, Zhigang, E-mail: enthuangzhigang@sohu.com [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)

    2013-06-21T23:59:59.000Z

    Highlights: •A novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors was defined. •GPR65 was identified to induce the MMP3 expression. •GPR65 mediated MMP induction under acidic conditions. •AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. •GPR65 overexpression can accelerate the invision of A549 cells. -- Abstract: Matrix metalloproteinases (MMPs) are over-expressed in nearly all cancers. To study novel regulatory factors of MMP expression in head and neck cancer (HNC), we screened a total of 636 candidate genes encoding putative human transmembrane proteins using MMP promoter reporter in a dual luciferase assay system. Three genes GPR65, AXL and TNFRSF10B dramatically activated the induction of MMP3 expression. The induction of MMP expression by GPR65 was further confirmed in A549 and/or FaDu cells. GPR65 mediated MMP induction under acidic conditions. The AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. Moreover, the A549 cells infected by recombinant adenovirus of GPR65 showed accelerated cell invasion. In conclusion, we validate that GPR65 is vital regulatory genes upstream of MMP3, and define a novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors.

  3. High-throughput single-molecule fluorescence spectroscopy using parallel detection

    E-Print Network [OSTI]

    Michalet, Xavier

    -molecule imaging). In this section, we briefly discuss the technique and data analysis used in standard solution-based , S. Tisad , F. Zappad , S. Covad , S. Weissa a Dept of Chemistry & Biochemistry, Los Angeles, CA, USA 90095; b Nesher Technologies, Los Angeles, CA; c Dept of Physics & Astronomy, UCLA, Los Angeles, CA

  4. High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael Kahn a

    E-Print Network [OSTI]

    Senkan, Selim M.

    of propylene. In less than a day, over 40 different catalytic materials of nanoparticles supported on g-Al2O3 oxidation products of propylene with one-pass yields of about 13% at 275 8C. # 2006 Published by Elsevier B of propylene oxide from propylene, hydrogen and oxygen [5]. On the other hand, larger Au nanoparticles result

  5. A high-throughput three-dimensional cell migration assay for toxicity screening

    E-Print Network [OSTI]

    Diseases, University of Texas Health Science Center, Houston, TX 77030 USA. There is a growing demand,19­21 . These nanoparticles are nontoxic and do not induce an inflammatory cytokine (IL-6, IL-8) response by cells22 they interact and aggregate with each other to form larger 3D cultures. This method has been shown to induce

  6. High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling

    E-Print Network [OSTI]

    King, Kevin R. (Kevin Robert), 1976-

    2008-01-01T23:59:59.000Z

    The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...

  7. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray

    E-Print Network [OSTI]

    Hook, Andrew L.

    Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with ...

  8. Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics

    E-Print Network [OSTI]

    Hu, Lei

    2012-12-31T23:59:59.000Z

    simultaneously, including UV absorption, light scattering, and near- and far- UV CD by employing a multimodal spectrometer (Chapter 2). Fluorescence spectral data are also collected on the same instrument although not simultaneously. The method is developed...

  9. analyzing high-throughput sequencing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    biological sample analysis abundance variabilities within sample cohorts. Mass spectrometry (MS) based platforms have attracted Clemmer, David E. 11 The use of coded PCR...

  10. High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

    E-Print Network [OSTI]

    Davenport, Jason; Blach, Maurie; Galam, Lakshmi; Girgis, Antwan; Hall, Jessica; Blagg, Brian S. J.; Matts, Robert L.

    2014-03-03T23:59:59.000Z

    Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a ...

  11. A high-throughput microfluidic device to study neurite response to growth factor gradients

    E-Print Network [OSTI]

    Kothapalli, Chandrasekhar R.

    Studying neurite guidance by diffusible or substrate bound gradients is challenging with current techniques. In this study, we present the design, fabrication and utility of a microfluidic device to study neurite guidance ...

  12. Cyber-T web server: differential analysis of high-throughput data

    E-Print Network [OSTI]

    Kayala, M. A; Baldi, P.

    2012-01-01T23:59:59.000Z

    10.1093/nar/gks420 Cyber-T web server: differential analysisin the Cyber-T web server, is one of the most widelyan update to the Cyber-T web server, incorporating several

  13. Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics

    E-Print Network [OSTI]

    Hughes, Travis K.

    An innovative, microwell-based platform for single-cell RNA sequencing (RNA-seq) combines cost efficiency, scalability and parallelizability, and will enable many new avenues of biological inquiry.

  14. PVD synthesis and high-throughput property characterization of Ni?Fe?Cr alloy libraries

    SciTech Connect (OSTI)

    Rar, A.; Frafjord, J.J.; Fowlkes, Jason D.; Specht, E.D.; Rack, P.D.; Santella, M.L.; Bei, H.; George, E.P.; Pharr, G.M. (Tennessee-K); (Tennessee-K); (ORNL)

    2010-11-10T23:59:59.000Z

    Three methods of alloy library synthesis, thick-layer deposition followed by interdiffusion, composition-spread codeposition and electron-beam melting of thick deposited layers, have been applied to Ni-Fe-Cr ternary and Ni-Cr binary alloys. Structural XRD mapping and mechanical characterization by means of nanoindentation have been used to characterize the properties of the libraries. The library synthesis methods are compared from the point of view of the structural and mechanical information they can provide.

  15. Discovery and High-Throughput Screening of Heteroleptic Iridium Complexes for Photoinduced Hydrogen Production

    E-Print Network [OSTI]

    Bernhard, Stefan

    researchers. Simple solar devices focus or collect sunlight, harnessing radiation in order to heat dwellings December 3, 2004; E-mail: sbernhar@princeton.edu Abstract: The catalytic process of photoinduced hydrogen of the hydrogen evolution process and facilitated mechanistic studies. All six compounds investigated produced

  16. A GPU-Like Soft Processor for High-Throughput Acceleration

    E-Print Network [OSTI]

    Steffan, J. Gregory

    into a blade server platform, and XtremeData and Nallatech that offer FPGA accelerator modules that can of the implementation, testing, and debugging required for devel- oping real hardware. Behavioral synthesis techniques the advantages of (i) supporting a familiar programming model and environment and (ii) being portable across

  17. High throughput 3D optical microscopy : from image cytometry to endomicroscopy

    E-Print Network [OSTI]

    Choi, Heejin

    2014-01-01T23:59:59.000Z

    Optical microscopy is an imaging technique that allows morphological mapping of intracellular structures with submicron resolution. More importantly, optical microscopy is a technique that can readily provide images with ...

  18. High-throughput Characterization of Porous Materials Using Graphics Processing Units

    E-Print Network [OSTI]

    Kim, Jihan

    2013-01-01T23:59:59.000Z

    A.E. ; Purcell, T. Computer Graphics Forum 2007, 26(1), 80-of Porous Materials Using Graphics Processing Units Jihanof Porous Materials Using Graphics Processing Units Jihan

  19. Multi-Channel and Multi-Rate Adaptation for High-Throughput Wireless Networks

    E-Print Network [OSTI]

    Nguyen, Duy Duc

    2012-01-01T23:59:59.000Z

    layer. Unlike wired networks, wireless networks have to deal2 Background Wireless Networks Wireless technology is allWLAN), wireless mesh networks, wireless metropolitan area

  20. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies 

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  1. Lensfree Optical Tomography for High-Throughput 3D Imaging on a Chip

    E-Print Network [OSTI]

    ISIKMAN, SERHAN OMER

    2012-01-01T23:59:59.000Z

    microscope with light-emitting diode illumination. Opt.source such as a light emitting diode (LED). The fundamentalchip microscope, 24 light-emitting diodes (LEDs - each with

  2. Improving the Yeast Three-Hybrid System for High-Throughput Target Discovery

    E-Print Network [OSTI]

    Bailey, Kyle

    2011-05-27T23:59:59.000Z

    fluorescence produced with only the yEGFP reporter (light gray) and maximal fluorescence with reporter activated by a LexA-B42 fusion (dark gray). Taken with permission from (Clark, D. D.; Peterson, B. R. Chembiochem 2005, 6, 1442). ............ 28 Figure 2... of induced yeast lacking LexA-B42 (red histogram). C) Table of relevant statistics taken from histograms. The median signal and coefficient of variation (CV) is taken from the gated population of induced cells bearing the complete system (black histogram...

  3. HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP

    E-Print Network [OSTI]

    , academia, and national laboratories. The objectives of this meeting were to: · Assess the potential is solution-based with solids handling similar to proven combinatorial methods. Exploration of new structures-ray scattering (SAXS) to determine pore size (needs development), hydrogen uptake me

  4. An ultra-high throughput mutational spectrometer for human genetic diagnostics

    E-Print Network [OSTI]

    Forest, Craig Richard, 1978-

    2007-01-01T23:59:59.000Z

    Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially ...

  5. Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine

    E-Print Network [OSTI]

    Chapin, Stephen Clifford

    2012-01-01T23:59:59.000Z

    The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

  6. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    10, March 2009. [35] Heng Li. Fastq format specification.Accessed: 10/16/2012. [36] Heng Li. Pileup format. http://Ac- cessed: 10/16/2012. [37] Heng Li. Mathematical notes on

  7. Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture

    E-Print Network [OSTI]

    Mittal, Sukant

    2012-01-01T23:59:59.000Z

    Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...

  8. Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide

    E-Print Network [OSTI]

    Pleskot, Dennis

    2013-01-01T23:59:59.000Z

    Strength of Monolayer Graphene Science 2008 321, 385-388. 5.Novoselov, K. S. The rise of graphene Nature 2007 6 183-191.A. Thermal properties of graphene and nanostructured carbon

  9. A high-throughput in vivo micronucleus assay for genome instability screening in mice

    E-Print Network [OSTI]

    Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen P; Adams, David J; McIntyre, Rebecca E

    2014-12-31T23:59:59.000Z

    .jackson@gurdon.cam.ac.uk; Ng BL – bln@sanger.ac.uk; Adams DJ – da1@sanger.ac.uk; McIntyre R – rm5@sanger.ac.uk; Primary articles: 20 McIntyre, R.E. et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet 8, e... into the mouse phenotyping pipeline, we have identified radiation-sensitive mutants, which exhibit increased levels of micronucleated-RET after irradiation but not before. Within this manuscript, 150 we provide additional details on data analysis...

  10. High Throughput Identification, Purification and Structural Characterization of Water Soluble Protein Complexes in Desulfovibrio vulgaris

    SciTech Connect (OSTI)

    Dong,, Ming; Han, Bong-Gyoon; Liu, Hui-Hai; Malik, J.; Geller, Jil; Yang, Li; Choi, M.; Chandonia, John-Marc; Arbelaez, Pablo; Sterling, H. J.; Typke, Dieter; Shatsky, Max; Brenner, Steve; Fisher, Susan; Williams, Evan; Szakal, Evelin; Allen, S.; Hall, S. C.; Hazen, Terry; Witkowska, H. E.; Jin, Jiming; Glaeser, Robert; Biggin, Mark

    2010-05-17T23:59:59.000Z

    Our scheme for the tagless purification of water soluble complexes. 10 g of protein from a crude bacterial extract is first fractionated by ammonium sulfate precipitation and then by a series of chromatographic steps: anion exchange (IEX), hydrophobic interaction (HIC), and finally size exclusion (Gel Filtration). Fractions from the last chromatography step are trypsin digested and peptides labeled with iTRAQ reagents to allow multiplexing and quantitation during mass spectrometric analysis. Elution profiles of identified proteins are then subjected to clustering analysis.

  11. High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens

    E-Print Network [OSTI]

    Tewhey, Ryan Stephen

    2012-01-01T23:59:59.000Z

    al. (2010). Evolution of MRSA during hospital transmissionphylogenetic tree CA-MRSA isolates and the reference strainand antibiotic resistance costs by MRSA. The ISME journal 4,

  12. Automated detection and classification of circulating cancer cells via high-throughput microscopy

    E-Print Network [OSTI]

    Agustin, Ramses Martinez

    2007-01-01T23:59:59.000Z

    sample (1/100 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-468) with highest positive

  13. High-throughput, single-worm tracking and analysis in Caenorhabditis elegans

    E-Print Network [OSTI]

    Yemini, Eviatar

    2013-01-08T23:59:59.000Z

    Microfluidic Environment. PLoS ONE 3, e2550 (2008). 18. Berri, S., Boyle, J. H., Tassieri, M., Hope, I. A. & Cohen, N. Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait. HFSP J 3, 186–193 (2009). 19. Fang-Yen, C. et...

  14. Design and fabrication of a microfluidies gradient generator system for high-throughput molecular interaction studies

    E-Print Network [OSTI]

    Chen, Guan-Jong, 1981-

    2004-01-01T23:59:59.000Z

    Design and fabrication of a microfluidics system capable of generating reproducible and controlled micro-biochemical environments that can be used as a diagnostic assay and microreactor is important. Here, a simple technique ...

  15. Hybrid CMOS/Nanodevice Circuits for High Throughput Pattern Matching Applications

    E-Print Network [OSTI]

    Sherwood, Tim

    , Timothy Sherwood2 , and Dmitri B. Strukov1* 1 Electrical and Computer Engineering Department, University Figure 1. Pattern matching with island-type FPGA circuits: (a) general idea, and (b) matching operation addressable memories (T/CAMs) (Fig. 2) [8, 9]. These approaches rely on patterns being loaded into specially

  16. Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical

    E-Print Network [OSTI]

    California at Riverside, University of

    Introduction Sustainable energy sources are needed to supplement petroleum use in light of limited reserves economically, a large number of factors such as feedstock quality, conversion conditions, and catalyst loadings as well as their complex interactions must be better evaluated to identify combina- tions that can

  17. High-throughput experimental and computational tools for exploring immunity and the microbiome

    E-Print Network [OSTI]

    Papa, Eliseo

    2012-01-01T23:59:59.000Z

    Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...

  18. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    rheology through microfluidics,” Advanced Materials, vol.Berthier and P. Silberzan, Microfluidics for Biotechnology.A. P. Lee, “Droplet microfluidics,” Lab on a Chip, vol. 8,

  19. High-Throughput 3D Structural Homology Detection via NMR Resonance Christopher James Langmead

    E-Print Network [OSTI]

    Richardson, David

    is the number of residues in the tar- get protein and c is the maximum edge weight in an integer- weighted for two dissimilar amino acid sequences to fold to the "same" ter- tiary structure. For example, the RMSD

  20. A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae

    E-Print Network [OSTI]

    Dangl, Jeff

    criteria defined 29 type III proteins from P. syringae pv. tomato, and 19 from P. syringae pv. phaseolicola [disease resistance (R) pro- teins], a battery of host responses is triggered, including localized