National Library of Energy BETA

Sample records for integrated high throughput

  1. A 96-well microplate incorporating a replica molded microfluidic network integrated with photonic crystal biosensors for high throughput kinetic

    E-Print Network [OSTI]

    Cunningham, Brian

    crystal biosensors for high throughput kinetic biomolecular interaction analysis{; Charles J. Choi microfluidic channels, with integrated label-free photonic crystal biosensors as the bottom surface the volume of reagent required to functionalize the biosensor surface, while retaining compatibility

  2. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  3. SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets

    E-Print Network [OSTI]

    Spencer, Sarah J.

    The rapid development of high throughput biotechnologies has led to an onslaught of data describing genetic perturbations and changes in mRNA and protein levels in the cell. Because each assay provides a one-dimensional ...

  4. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.

    2005-07-19

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  5. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)

    2007-09-25

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  6. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  7. Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control{

    E-Print Network [OSTI]

    Sinskey, Anthony J.

    Microbioreactor arrays with integrated mixers and fluid injectors for high- throughput, with 100 mL working volume, comprising a peristaltic oxygenating mixer and microfluidic injectors litre reference fermentation, conducted with the same strain, in a bench scale stirred tank bioreactor

  8. New Tools for High Throughput Chemistry and Biology 

    E-Print Network [OSTI]

    Galveia, Luciano Paulo Rosa

    2011-01-01

    New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...

  9. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)

    2009-09-08

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  10. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    White Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint...

  11. ASYNCHRONOUS WAVE PIPELINES FOR HIGH THROUGHPUT DATAPATHS

    E-Print Network [OSTI]

    Huss, Sorin A.

    ASYNCHRONOUS WAVE PIPELINES FOR HIGH THROUGHPUT DATAPATHS O. Hauck and S. A. Huss fhauck j hussg pipeline architecture for high­speed clockless computation is proposed. It features gate­level pipelining the advantages of wave pipelining and asynchronous operation, i. e. very high throughput at low latency while

  12. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Robust, High-Throughput Analysis of Protein Structures Robust, High-Throughput Analysis of Protein Structures Print Wednesday, 28 October 2009 00:00 Scientists have developed a...

  13. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...

  14. Potential of High-Throughput Experimentation with Ammonia Borane...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...

  15. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...

  16. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...

  17. High-throughput in vivo vertebrate screening

    E-Print Network [OSTI]

    Pardo-Martin, Carlos

    We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and ...

  18. Approaches to High Throughput Physical Organic Chemistry 

    E-Print Network [OSTI]

    Portal, Christophe

    2008-01-01

    Over the past ten years, the development of High Throughput (HT) synthetic chemistry techniques has allowed the rapid preparation of libraries of hundreds to thousands of compounds. These tools are now extensively used for drug and material...

  19. Chain Replication for Supporting High Throughput and Availability

    E-Print Network [OSTI]

    Keinan, Alon

    Chain Replication for Supporting High Throughput and Availability Robbert van Renesse rvr services that exhibit high throughput and availability with- out sacrificing strong consistency guarantees the perfor- mance characteristics of a prototype implementa- tion. Throughput, availability, and several

  20. Systematic reconstruction of RNA functional motifs with high throughput microfluidics

    E-Print Network [OSTI]

    Quake, Stephen R.

    Systematic reconstruction of RNA functional motifs with high throughput microfluidics Lance Martin1 Hill, NC 27599 Abstract We present RNA-MITOMI, a microfluidic platform for integrated synthesis microfluidic platform such that the entire RNA library could be simultaneously synthesized and then assayed

  1. The Design of High-Throughput Asynchronous Pipelines

    E-Print Network [OSTI]

    The Design of High-Throughput Asynchronous Pipelines Montek Singh Department of Computer Science UNIVERSITY December 2001 #12;The Design of High-Throughput Asynchronous Pipelines Montek Singh ABSTRACT is on high-throughput asynchronous pipelines, since pipelining is at the heart of most high

  2. The Design of HighThroughput Asynchronous Pipelines

    E-Print Network [OSTI]

    The Design of High­Throughput Asynchronous Pipelines Montek Singh Department of Computer Science UNIVERSITY December 2001 #12; The Design of High­Throughput Asynchronous Pipelines Montek Singh ABSTRACT is on high­throughput asynchronous pipelines, since pipelining is at the heart of most high

  3. Chemistry & Biology Genome-Wide High-Throughput Mining

    E-Print Network [OSTI]

    Yin, Jun

    Chemistry & Biology Article Genome-Wide High-Throughput Mining of Natural-Product Biosynthetic Gene.01.006 SUMMARY We have developed a phage-display method for high-throughput mining of bacterial gene clus- ters

  4. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D On June 26, 2007 the Hydrogen...

  5. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01

    Statistical Algorithms for High-throughput Biological Data by Kyowon Jeong Doctor of Philosophy in Electrical Engineering (Communication Theory

  6. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  7. High throughput chemical munitions treatment system

    DOE Patents [OSTI]

    Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)

    2011-11-01

    A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.

  8. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...

  9. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Robust, High-Throughput Analysis of Protein Structures Print Scientists have developed a fast and efficient way to determine the structure of proteins, shortening a process that...

  10. High-throughput metagenomic technologies for complex microbial...

    Office of Scientific and Technical Information (OSTI)

    formats Prev Next Title: High-throughput metagenomic technologies for complex microbial community analysis. Open and closed formats You are accessing a document from...

  11. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...

  12. High-Throughput Program for the Discovery of NOx Reduction Catalysts...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput Program for the Discovery of NOx Reduction Catalysts High-Throughput Program for the Discovery of NOx Reduction Catalysts 2004 Diesel Engine Emissions Reduction...

  13. Development and optimization of high-throughput zebrafish screening platform

    E-Print Network [OSTI]

    Koo, Bryan Kyo

    2010-01-01

    The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...

  14. High-throughput vertebrate total analysis/screening platform

    E-Print Network [OSTI]

    Chang, Tsung-Yao, Ph. D. Massachusetts Institute of Technology

    2012-01-01

    High-throughput screening (HTS) is seen as one of the most promising technologies to facilitate biomedical studies and pharmaceutical discoveries. Although large varieties of in vitro HTS technologies have opened great ...

  15. High-Throughput Methodology for Discovery of Metal-Organic Frameworks...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput Methodology for Discovery of Metal-Organic Frameworks with a High Binding Energy (New Joint UC-BerkeleySymyx DoDDLA Project) (presentation) High-Throughput...

  16. High-ThroughputTagging of Arabidopsis Proteins

    E-Print Network [OSTI]

    Citovsky, Vitaly

    ­0124 (N.C., G.D., N.V.R.); and The Arabidopsis Information Resource (S.L., S.Y.R.) and Carnegie Institution of Washington (S.L., D.E., S.Y.R), Stanford, California 94305 We developed a high their chromogenic reac- tion products (Taylor, 1997). The use of antigenic tags, such as the T7 or HA epitopes

  17. Agenda from the U.S. Department of Energy's High Throughput Screening...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...

  18. Methods and technologies for high-throughput and high-content small animal screening

    E-Print Network [OSTI]

    Rohde, Christopher, 1979-

    2012-01-01

    High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...

  19. High-throughput screening for modulators of cellular contractile force

    E-Print Network [OSTI]

    Park, Chan Young; Tambe, Dhananjay; Chen, Bohao; Lavoie, Tera; Dowell, Maria; Simeonov, Anton; Maloney, David J; Marinkovic, Aleksandar; Tschumperlin, Daniel J; Burger, Stephanie; Frykenberg, Matthew; Butler, James P; Stamer, W Daniel; Johnson, Mark; Solway, Julian; Fredberg, Jeffrey J; Krishnan, Ramaswamy

    2014-01-01

    When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signaling intermediates with poorly defined relationship to such a physiological endpoint. Using cellular force as the target, here we screened libraries to identify novel drug candidates in the case of human airway smooth muscle cells in the context of asthma, and also in the case of Schlemm's canal endothelial cells in the context of glaucoma. This approach identified several drug candidates for both asthma and glaucoma. We attained rates of 1000 compounds per screening day, thus establishing a force-based cellular platform for high-throughput drug discovery.

  20. SAMDI Mass Spectrometry for High Throughput Discovery of Enzyme Function |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis of Protein StructuresMaintenance /

  1. PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela Zavaljevski, and Jaques Reifman

    E-Print Network [OSTI]

    PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela of multisource predictions. We developed Pipeline for Protein Annotation (PIPA), a genome-wide protein function annotation pipeline that runs in a high-performance computing environment. PIPA integrates different tools

  2. Environmental characterization studies of a high-throughput wood gasifier

    SciTech Connect (OSTI)

    Chang, H.; Niemann, R.C.; Wilzbach, K.E.; Paisley, M.

    1983-01-01

    Potential environmental effects associated with thermochemical biomass gasification have been studied by Argonne National Laboratory in cooperation with Battelle Columbus Laboratories (BCL). A series of samples from the process research unit of an indirectly heated, high-throughput wood gasifier operated by BCL has been analyzed for potentially toxic organic compounds and trace elements. The results indicate that, under the test-run conditions, the gasification of both pine and hardwood is accompanied by the formation of some oil, the heavier fraction of which gives a positive response in the Ames assay for mutagenicity and contains numerous phenols and polycyclic aromatic hydrocarbons, including some carcinogens. The implications of these observations are discussed.

  3. High-throughput sequencing of cytosine methylation in plant DNA

    E-Print Network [OSTI]

    Hardcastle, Thomas J.

    2013-06-07

    . Genome Res 2008, 18(7):1051–1063. 66. Bormann Chung CA, Boyd VL, McKernan KJ, Fu Y, Monighetti C, Peckham HE, Barker M: Whole methylome analysis by ultra-deep sequencing using two-base encoding. PloS One 2010, 5(2):e9320. 67. Ondov BD, Cochran C, Landers... reads. Bioinformatics 2013, 29(2):268–270. 70. Minoche AE, Dohm JC, Himmelbauer H: Evaluation of genomic high-throughput sequencing data generated on Illumina HiSeq and genome analyzer systems. Genome Biol 2011, 12(11):R112. 71. Wang XV, Blades N, Ding J...

  4. Computational Proteomics: High-throughput Analysis for Systems Biology

    SciTech Connect (OSTI)

    Cannon, William R.; Webb-Robertson, Bobbie-Jo M.

    2007-01-03

    High-throughput (HTP) proteomics is a rapidly developing field that offers the global profiling of proteins from a biological system. The HTP technological advances are fueling a revolution in biology, enabling analyses at the scales of entire systems (e.g., whole cells, tumors, or environmental communities). However, simply identifying the proteins in a cell is insufficient for understanding the underlying complexity and operating mechanisms of the overall system. Systems level investigations are relying more and more on computational analyses, especially in the field of proteomics generating large-scale global data.

  5. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis of Protein Structures Print Scientists have developed a fast and

  6. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis of Protein Structures Print Scientists have developed a fast

  7. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis of Protein Structures Print Scientists have developed a

  8. Automated High Throughput Protein Crystallization Screening at Nanoliter Scale and Protein Structural Study on Lactate Dehydrogenase

    SciTech Connect (OSTI)

    Fenglei Li

    2006-08-09

    The purposes of our research were: (1) To develop an economical, easy to use, automated, high throughput system for large scale protein crystallization screening. (2) To develop a new protein crystallization method with high screening efficiency, low protein consumption and complete compatibility with high throughput screening system. (3) To determine the structure of lactate dehydrogenase complexed with NADH by x-ray protein crystallography to study its inherent structural properties. Firstly, we demonstrated large scale protein crystallization screening can be performed in a high throughput manner with low cost, easy operation. The overall system integrates liquid dispensing, crystallization and detection and serves as a whole solution to protein crystallization screening. The system can dispense protein and multiple different precipitants in nanoliter scale and in parallel. A new detection scheme, native fluorescence, has been developed in this system to form a two-detector system with a visible light detector for detecting protein crystallization screening results. This detection scheme has capability of eliminating common false positives by distinguishing protein crystals from inorganic crystals in a high throughput and non-destructive manner. The entire system from liquid dispensing, crystallization to crystal detection is essentially parallel, high throughput and compatible with automation. The system was successfully demonstrated by lysozyme crystallization screening. Secondly, we developed a new crystallization method with high screening efficiency, low protein consumption and compatibility with automation and high throughput. In this crystallization method, a gas permeable membrane is employed to achieve the gentle evaporation required by protein crystallization. Protein consumption is significantly reduced to nanoliter scale for each condition and thus permits exploring more conditions in a phase diagram for given amount of protein. In addition, evaporation rate can be controlled or adjusted in this method during the crystallization process to favor either nucleation or growing processes for optimizing crystallization process. The protein crystals gotten by this method were experimentally proven to possess high x-ray diffraction qualities. Finally, we crystallized human lactate dehydrogenase 1 (H4) complexed with NADH and determined its structure by x-ray crystallography. The structure of LDH/NADH displays a significantly different structural feature, compared with LDH/NADH/inhibitor ternary complex structure, that subunits in LDH/NADH complex show open conformation or two conformations on the active site while the subunits in LDH/NADH/inhibitor are all in close conformation. Multiple LDH/NADH crystals were obtained and used for x-ray diffraction experiments. Difference in subunit conformation was observed among the structures independently solved from multiple individual LDH/NADH crystals. Structural differences observed among crystals suggest the existence of multiple conformers in solution.

  9. High Throughput Pretreatment and Enzyme Hydrolysis of Biomass: Screening Recalcitrance in Large Sample Populations (Presentation)

    SciTech Connect (OSTI)

    Decker, S. R.

    2010-10-01

    Presentation on the execution of the first high-throughput thermochemical pretreatment/enzyme digestion pipeline for screening biomass for recalcitrance.

  10. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  11. Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens

    E-Print Network [OSTI]

    Scott, Matthew

    Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens Stefan developed an automated system based on microelectromechanical systems (MEMS) injectors for reliable mass

  12. CONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING

    E-Print Network [OSTI]

    Deng, Xunming

    CONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING M. Izu, H. When this technique is incorporated into a continuous roll- to-roll PV manufacturing process a number of advantages in a fully automated high throughput PV module production plant [l-18

  13. Improving Bounds on the Football Pool Problem via Symmetry Reduction and High-Throughput Computing

    E-Print Network [OSTI]

    Linderoth, Jeffrey T.

    Improving Bounds on the Football Pool Problem via Symmetry Reduction and High-Throughput Computing of Wisconsin-Madison, 1210 W. Dayton St., Madison, WI 53706, USA, gthain@cs.wisc.edu The Football Pool Problem theory. Key words: Football Pool Problem; High-Throughput Computing; Branch-and-Bound; Con- dor; Master

  14. HPAZ: a High-throughput Pipeline Architecture of ZUC in Zongbin Liu1

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    HPAZ: a High-throughput Pipeline Architecture of ZUC in Hardware Zongbin Liu1 , Neng Gao1 , Jiwu@ist.psu.edu Abstract. In this paper, we propose a high-throughput pipeline architecture of the stream cipher ZUC which significantly reduces operating frequency. In this paper we design a mixed two-stage pipeline architecture which

  15. Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab-Initio Calculations

    E-Print Network [OSTI]

    Curtarolo, Stefano

    Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab Database have been considered as nanograined, sintered-powder thermoelectrics with the high-throughput ab the electronic band gap and the carrier effective mass, and that the probability of having large thermoelectric

  16. Solion ion source for high-efficiency, high-throughput solar cell manufacturing

    SciTech Connect (OSTI)

    Koo, John Binns, Brant; Miller, Timothy; Krause, Stephen; Skinner, Wesley; Mullin, James

    2014-02-15

    In this paper, we introduce the Solion ion source for high-throughput solar cell doping. As the source power is increased to enable higher throughput, negative effects degrade the lifetime of the plasma chamber and the extraction electrodes. In order to improve efficiency, we have explored a wide range of electron energies and determined the conditions which best suit production. To extend the lifetime of the source we have developed an in situ cleaning method using only existing hardware. With these combinations, source life-times of >200 h for phosphorous and >100 h for boron ion beams have been achieved while maintaining 1100 cell-per-hour production.

  17. Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi

    E-Print Network [OSTI]

    David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar

    2014-10-10

    Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).

  18. Opal: A Multi-radio Platform for High Throughput Wireless Sensor Networks

    E-Print Network [OSTI]

    Langendoen, Koen

    1 Opal: A Multi-radio Platform for High Throughput Wireless Sensor Networks Raja Jurdak, Kevin requirements. This letter presents the design of the versatile Opal platform that couples a Cortex M3 MCU sacrificing communication range. We present experiments that evaluate Opal's throughput and range when

  19. Low inlet gas velocity high throughput biomass gasifier

    SciTech Connect (OSTI)

    Feldmann, Herman F.; Paisley, Mark A.

    1989-01-01

    The present invention discloses a novel method of operating a gasifier for production of fuel gas from carbonaceous fuels. The process disclosed enables operating in an entrained mode using inlet gas velocities of less than 7 feet per second, feedstock throughputs exceeding 4000 lbs/ft.sup.2 -hr, and pressures below 100 psia.

  20. The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory

    E-Print Network [OSTI]

    Jain, Anubhav, Ph.D. Massachusetts Institute of Technology

    2011-01-01

    This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...

  1. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  2. CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy

    E-Print Network [OSTI]

    Kang, InHan

    2006-01-01

    In this thesis, we present a system for visualizing hierarchical, multi-dimensional, memory-intensive datasets. Specifically, we designed an interactive system to visualize data collected by high-throughput microscopy and ...

  3. Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)

    E-Print Network [OSTI]

    Xu, F.

    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...

  4. Infrastructure to support ultra high throughput biodosimetry screening after a radiological event

    E-Print Network [OSTI]

    Brenner, David Jonathan

    GUY GARTY1 , ANDREW KARAM2 , & DAVID J. BRENNER3 1 Radiological Research Accelerator Facility, Radiological Research Accelerator Facility, Nevis Laboratories, Columbia UniverInfrastructure to support ultra high throughput biodosimetry screening after a radiological event

  5. Engineering a single cell microarray platform for high throughput DNA damage and repair analysis

    E-Print Network [OSTI]

    Weingeist, David McGregor

    2012-01-01

    DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ...

  6. An instrument for high-throughput measurements of fiber mechanical properties

    E-Print Network [OSTI]

    Kristofek, Grant William, 1980-

    2005-01-01

    In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...

  7. Stochastic Forecasts Achieve High Throughput and Low Delay over Cellular Networks

    E-Print Network [OSTI]

    Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Balakrishnan, Hari; Winstein, Keith J.; Sivaraman Kaushalram, Anirudh; Balakrishnan, Hari

    Sprout is an end-to-end transport protocol for interactive applications that desire high throughput and low delay. Sprout works well over cellular wireless networks, where link speeds change dramatically with time, and ...

  8. Software for supporting large scale data processing for High Throughput Screening

    E-Print Network [OSTI]

    Tai, David

    2011-12-31

    High Throughput Screening for is a valuable data generation technique for data driven knowledge discovery. Because the rate of data generation is so great, it is a challenge to cope with the demands of post experiment data analysis. This thesis...

  9. Inertio-elastic focusing of bioparticles in microchannels at high throughput

    E-Print Network [OSTI]

    Lim, Eugene J.

    Controlled manipulation of particles from very large volumes of fluid at high throughput is critical for many biomedical, environmental and industrial applications. One promising approach is to use microfluidic technologies ...

  10. A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a

    E-Print Network [OSTI]

    Wood, Thomas K.

    A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow

  11. Attendees list from the U.S. Department of Energy's High Throughput...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...

  12. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays

    E-Print Network [OSTI]

    Sun, Yu

    A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial8, Canada b Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College 16 September 2009 Available online 9 October 2009 Keywords: Hydrogel Micropatterning Biomaterial

  13. First principles high throughput screening of oxynitrides for water-splitting photocatalysts

    E-Print Network [OSTI]

    Wu, Yabi

    2013-01-01

    In this paper, we present a first principles high throughput screening system to search for new water-splitting photocatalysts. We use the approach to screen through nitrides and oxynitrides. Most of the known photocatalytic ...

  14. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System 

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  15. High-throughput generation, optimization and analysis of genome-scale metabolic models.

    SciTech Connect (OSTI)

    Henry, C. S.; DeJongh, M.; Best, A. A.; Frybarger, P. M.; Linsay, B.; Stevens, R. L.

    2010-09-01

    Genome-scale metabolic models have proven to be valuable for predicting organism phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with genome sequencing. To address this problem, we introduce the Model SEED, a web-based resource for high-throughput generation, optimization and analysis of genome-scale metabolic models. The Model SEED integrates existing methods and introduces techniques to automate nearly every step of this process, taking {approx}48 h to reconstruct a metabolic model from an assembled genome sequence. We apply this resource to generate 130 genome-scale metabolic models representing a taxonomically diverse set of bacteria. Twenty-two of the models were validated against available gene essentiality and Biolog data, with the average model accuracy determined to be 66% before optimization and 87% after optimization.

  16. Optical Multiplexing for High-Throughput Spectroscopic Analysis. 

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03

    in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...

  17. PARALLEL HIGH THROUGHPUT SOFT-OUTPUT SPHERE DECODER Q. Qi, C. Chakrabarti

    E-Print Network [OSTI]

    Kambhampati, Subbarao

    - putation complexity of only the list generator. Recently, a high speed systolic-like soft-output spherePARALLEL HIGH THROUGHPUT SOFT-OUTPUT SPHERE DECODER Q. Qi, C. Chakrabarti School of Electrical,chaitali}@asu.edu ABSTRACT Multiple-Input-Multiple-Output communication systems de- mand fast sphere decoding with high

  18. Low inlet gas velocity high throughput biomass gasifier

    SciTech Connect (OSTI)

    Feldmann, H.F.; Paisley, M.A.

    1989-05-09

    A method is described for operating a gasifier which comprises: introducing inlet gas at a velocity of about 0.5 to 7 ft/sec to fluidize a bed in a gasifier vessel; forming the bed into a fluidized bed in a first space region by means of the inlet gas, the fluidized bed containing a circulating hot relatively fine and inert solid bed particle component; inputting and throughputting carbonaceous material into and through the first space region with fluidized bed at a rate from 500-4400 lbs/ft/sup 2/-hr; endothermally pyrolyzing the carbonaceous material by means of the circulating hot inert particle component so as to form a product gas; forming contiguous to and above the fluidized bed a lower average density entrained space region containing an entrained mixture of inert solid particles, char, and carbonaceous material and the product gas; gradually and continuously removing the entrained mixture and the product gas from the lower average density entrained space region of the gasifier to a separator, residence time of the carbonaceous material in the gasifier not exceeding 3 minutes on average; separating the entrained mixture from the product gas; passing the entrained mixture containing inert solid particles, char, and carbonaceous material through an exothermic reaction zone to add heat; and returning at least the inert solid particles to the first space region.

  19. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Perrimon, Norbert

    Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range

  20. A search model for topological insulators with high-throughput robustness descriptors

    SciTech Connect (OSTI)

    Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano

    2012-05-13

    Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.

  1. FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

    SciTech Connect (OSTI)

    Rathke, P.M.

    1993-09-01

    The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of the HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.

  2. Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,

    E-Print Network [OSTI]

    Basu, Amar S.

    Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest

  3. UFlood: High-Throughput Flooding over Wireless Mesh Networks Jayashree Subramanian, Robert Morris, and Hari Balakrishnan

    E-Print Network [OSTI]

    UFlood: High-Throughput Flooding over Wireless Mesh Networks Jayashree Subramanian, Robert Morris--This paper proposes UFlood, a flooding protocol for wireless mesh networks. UFlood targets situations of completion of a flood to the slowest receiving node and total time spent transmitting. The key to achieving

  4. User, Robot and Automation Evaluations in High-Throughput Biological Screening Processes

    E-Print Network [OSTI]

    Kaber, David B.

    User, Robot and Automation Evaluations in High-Throughput Biological Screening Processes Noa Segall Cognitive Ergonomics Laboratory North Carolina State University Raleigh, NC +1 (919) 513-4494 nsegall@ncsu.edu Rebecca S. Green Cognitive Ergonomics Laboratory North Carolina State University Raleigh, NC +1 (919) 513

  5. Achieving High Throughput Ground-to-UAV Transport via Parallel Links

    E-Print Network [OSTI]

    Kung, H. T.

    Achieving High Throughput Ground-to-UAV Transport via Parallel Links Chit-Kwan Lin, H. T. Kung in unmanned aerial vehicle (UAV) applications, is a challenge due to varying channel quality and extended link diversity; 802.11; link layer; transport layer; UAV; network coding I. INTRODUCTION In this paper, we focus

  6. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Higgins, Darren

    , Lexington, MA 02421; and bGenetics Department, Harvard Medical School and cHoward Hughes Medical Institute oil and enables the digital manipulation of these reactors at a very high-throughput. Here, we by an immiscible oil. The advantages of this droplet- based technique include the physical and chemical isolation

  7. Comparison of High-Throughput Electrochemical Methods for Testing Direct Methanol Fuel Cell Anode Electrocatalysts

    E-Print Network [OSTI]

    power applications, fuel cells must compete with commodity power sources such as fossil fuels power sources, and mobile/portable applications, fuel cells that utilize liquid fuels can representComparison of High-Throughput Electrochemical Methods for Testing Direct Methanol Fuel Cell Anode

  8. Knife-Edge Scanning Microscopy: High-throughput Imaging and Analysis of

    E-Print Network [OSTI]

    Choe, Yoonsuck

    : High-throughput Imaging and Analysis of Massive Volumes of Biological Microstructures Author 1 Yoonsuck Choe Author 1 - Address Department of Computer Science, Texas A&M Univ. 3112 TAMU, College Station, TX, 77843-3112, USA Author 1 - Email choe@tamu.edu Author 1 - Tel +1 979 845 5466 Author 2 Louise C. Abbott

  9. Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation, #12;54 A. Shahab et al. portal solution for grid computing in life sciences under the auspices, and the use of a GridSpeed [6] generated iGAP application portal are described. The portal solution was part

  10. S-box pipelining using genetic algorithms for high-throughput AES implementations: How

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    S-box pipelining using genetic algorithms for high-throughput AES implementations: How fast can we. In this manuscript, we explore how Genetic Algorithms (GAs) can be used for pipelining the AES substitution box based the implementation area [5,6]. However, when considering fast hardware implementations, pipelining is an obvious

  11. TECHNICAL ADVANCE A high-throughput method for quantifying growth of

    E-Print Network [OSTI]

    Dangl, Jeff

    : Arabidopsis, resistance genes, Pseudomonas syringae, phytopathogenic bacteria, counting bacteria IntroductionTECHNICAL ADVANCE A high-throughput method for quantifying growth of phytopathogenic bacteria; email: dangl@email.unc.edu) Summary Measuring the growth of pathogenic bacteria in leaves is a mainstay

  12. ORIGINAL ARTICLE GeoChip 3.0 as a high-throughput tool for analyzing

    E-Print Network [OSTI]

    Thomas, David D.

    significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute in microbial ecology Keywords: microarray; functional genes; microbial community; plant diversity Introduction

  13. ORIGINAL ARTICLE GeoChip 3.0 as a high-throughput tool for analyzing

    E-Print Network [OSTI]

    Hazen, Terry

    significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute Keywords: microarray; functional genes; microbial community; plant diversity Introduction Microorganisms

  14. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  15. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    2014-11-17

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  16. Journal of Power Sources 158 (2006) 6068 High throughput evaluation of perovskite-based anode catalysts

    E-Print Network [OSTI]

    Mukasyan, Alexander

    2006-01-01

    Journal of Power Sources 158 (2006) 60­68 High throughput evaluation of perovskite-based anode to 25 compositions simultaneously under DMFC conditions. It was found that the Sr-based perovskites.g. perovskites, cuprates, etc.) Corresponding author. Tel.: +1 765 494 4075; fax: +1 765 494 0805. E

  17. Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical

    E-Print Network [OSTI]

    Zhu, Xiangdong

    Oblique-incidence reflectivity difference microscope for label-free high-throughput detection (OI-RD) microscope, a form of polarization-modulated imaging ellipsometer, for label on the polarizer­ compensator­sample­analyzer scheme and under the off-null condition, a polarization-modulated OI

  18. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural

    E-Print Network [OSTI]

    Hendrickson, Wayne A.

    The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform Springer Science+Business Media B.V. 2010 Abstract The New York Consortium on Membrane Protein Structure Core Laboratory, New York Structural Biology Center, New York, NY 10027, USA F. Mancia Á M. Zhou

  19. nAture methods | VOL.12 NO.1 | JANUARY2015 | 71 high-throughput methods based on chromosome conformation

    E-Print Network [OSTI]

    Cai, Long

    that of hi-c. coupling this method with dnA-capture technology provides a high-throughput approachArticles nAture methods | VOL.12 NO.1 | JANUARY2015 | 71 high-throughput methods based for targeted mapping of fine-scale chromatin architecture. We applied targeted dnase hi-c to characterize the 3

  20. MEMORY SUB-BANKING SCHEME FOR HIGH THROUGHPUT TURBO DECODER Mayank Tiwari, Yuming Zhu and Chaitali Chakrabarti

    E-Print Network [OSTI]

    Kambhampati, Subbarao

    level are needed in order to design low-power high- throughput Turbo decoders for mobile systems, the sliding win- dow (SW) approach has been proposed as an effective means of reduc- ing the decoding delay-banked implemen- tation of the SW-based approach that achieves high throughput, low decoding latency and reduced

  1. High-throughput metagenomic technologies for complex microbial...

    Office of Scientific and Technical Information (OSTI)

    within the context of environmental applications and focus on analysis of complex microbial systems, such as those in soils, in which diversity is high and reference...

  2. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...

  3. High Efficiency Integrated Package

    SciTech Connect (OSTI)

    Ibbetson, James

    2013-09-15

    Solid-state lighting based on LEDs has emerged as a superior alternative to inefficient conventional lighting, particularly incandescent. LED lighting can lead to 80 percent energy savings; can last 50,000 hours – 2-50 times longer than most bulbs; and contains no toxic lead or mercury. However, to enable mass adoption, particularly at the consumer level, the cost of LED luminaires must be reduced by an order of magnitude while achieving superior efficiency, light quality and lifetime. To become viable, energy-efficient replacement solutions must deliver system efficacies of ? 100 lumens per watt (LPW) with excellent color rendering (CRI > 85) at a cost that enables payback cycles of two years or less for commercial applications. This development will enable significant site energy savings as it targets commercial and retail lighting applications that are most sensitive to the lifetime operating costs with their extended operating hours per day. If costs are reduced substantially, dramatic energy savings can be realized by replacing incandescent lighting in the residential market as well. In light of these challenges, Cree proposed to develop a multi-chip integrated LED package with an output of > 1000 lumens of warm white light operating at an efficacy of at least 128 LPW with a CRI > 85. This product will serve as the light engine for replacement lamps and luminaires. At the end of the proposed program, this integrated package was to be used in a proof-of-concept lamp prototype to demonstrate the component’s viability in a common form factor. During this project Cree SBTC developed an efficient, compact warm-white LED package with an integrated remote color down-converter. Via a combination of intensive optical, electrical, and thermal optimization, a package design was obtained that met nearly all project goals. This package emitted 1295 lm under instant-on, room-temperature testing conditions, with an efficacy of 128.4 lm/W at a color temperature of ~2873K and 83 CRI. As such, the package’s performance exceeds DOE’s warm-white phosphor LED efficacy target for 2013. At the end of the program, we assembled an A19 sized demonstration bulb housing the integrated package which met Energy Star intensity variation requirements. With further development to reduce overall component cost, we anticipate that an integrated remote converter package such as developed during this program will find application in compact, high-efficacy LED-based lamps, particularly those requiring omnidirectional emission.

  4. High-Throughput Bioscience Center (HTBC) History and Mission

    E-Print Network [OSTI]

    Kay, Mark A.

    pipettor (5-200 uL) Primary used for hit picking #12;SciClone ALH3000 Low Volume Head Can exchange heads3000 SciClone ALH3000, featuring... High Volume Head 96 disposal-tip pipettor (5-200 uL) Can change for 96 to 96 plate replication and 96 to 384 plate reformatting Z8 Head 8 independent disposable tip

  5. High Throughput/Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High

  6. High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡HighApproaches | Department of

  7. High-Throughput and Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls - Building America Topa High Binding Energy

  8. High-Throughput Analytical Model to Evaluate Materials for Temperature

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you notHeat Pumps Heat Pumps An error occurred. Try|High-Powered

  9. High-throughput metagenomic technologies for complex microbial community

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers (Journal Article)SciTechHigh-contrastproperties ofwallanalysis.

  10. High-throughput metagenomic technologies for complex microbial community

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(Journal Article)lasers (Journal Article)SciTechHigh-contrastproperties

  11. High Throughput Combinatorial Screening of Biometic Metal-Organic Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High HIGHofWasteDepartmentfor

  12. High-throughput metagenomic technologies for complex microbial community analysis. Open and closed formats

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhou, Jizhong; He, Zhili; Yang, Yunfeng; Deng, Ye; Tringe, Susannah G.; Alvarez-Cohen, Lisa

    2015-01-27

    Understanding the structure, functions, activities and dynamics of microbial communities in natural environments is one of the grand challenges of 21st century science. To address this challenge, over the past decade, numerous technologies have been developed for interrogating microbial communities, of which some are amenable to exploratory work (e.g., high-throughput sequencing and phenotypic screening) and others depend on reference genes or genomes (e.g., phylogenetic and functional gene arrays). Here, we provide a critical review and synthesis of the most commonly applied “open-format” and “closed-format” detection technologies. We discuss their characteristics, advantages, and disadvantages within the context of environmental applications andmore »focus on analysis of complex microbial systems, such as those in soils, in which diversity is high and reference genomes are few. In addition, we discuss crucial issues and considerations associated with applying complementary high-throughput molecular technologies to address important ecological questions.« less

  13. Integrated microbioreactor arrays for high-throughput experimentation

    E-Print Network [OSTI]

    Lee, Harry, 1976-

    2006-01-01

    Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...

  14. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

    SciTech Connect (OSTI)

    Hura, Greg L.; Menon, Angeli L.; Hammel, Michal; Rambo, Robert P.; Poole II, Farris L.; Tsutakawa, Susan E.; Jenney Jr, Francis E.; Classen, Scott; Frankel, Kenneth A.; Hopkins, Robert C.; Yang, Sungjae; Scott, Joseph W.; Dillard, Bret D.; Adams, Michael W. W.; Tainer, John A.

    2009-07-20

    We present an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering (SAXS). Our SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving. We subjected 50 representative proteins, mostly from Pyrococcus furiosus, to this pipeline and found that 30 were multimeric structures in solution. SAXS analysis allowed us to distinguish aggregated and unfolded proteins, define global structural parameters and oligomeric states for most samples, identify shapes and similar structures for 25 unknown structures, and determine envelopes for 41 proteins. We believe that high-throughput SAXS is an enabling technology that may change the way that structural genomics research is done.

  15. Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing

    E-Print Network [OSTI]

    Mueller, Tim

    Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...

  16. High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials

    E-Print Network [OSTI]

    Hautier, Geoffroy (Geoffroy T. F.)

    2011-01-01

    The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...

  17. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Athavale, Ajay [Monsanto

    2013-01-25

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  18. Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Jordan, Scott [Physik Instrumente

    2013-02-11

    Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  19. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    SciTech Connect (OSTI)

    Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research

    2011-10-12

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  20. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    ScienceCinema (OSTI)

    Gore, Brooklin [Morgridge Institute for Research

    2013-01-22

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  1. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    SciTech Connect (OSTI)

    Athavale, Ajay [Monsanto] [Monsanto

    2012-06-01

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  2. High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins

    DOE Patents [OSTI]

    Kim, Sung-Hou (Moraga, CA); Kim, Rosalind (Moraga, CA); Jancarik, Jamila (Walnut Creek, CA)

    2012-01-31

    An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.

  3. Enabling a High Throughput Real Time Data Pipeline for a Large Radio Telescope Array with GPUs

    E-Print Network [OSTI]

    Edgar, R G; Dale, K; Mitchell, D A; Ord, S M; Wayth, R B; Pfister, H; Greenhill, L J

    2010-01-01

    The Murchison Widefield Array (MWA) is a next-generation radio telescope currently under construction in the remote Western Australia Outback. Raw data will be generated continuously at 5GiB/sec. This high throughput motivates the development of on-site, real time processing and reduction in preference to archiving, transport and off-line processing. Maintaining real time operation will require a sustained performance of around 2.5TFLOP/sec (including convolutions, FFTs, interpolations and matrix multiplications). We describe a scalable heterogeneous computing pipeline implementation, exploiting both the high computing density and FLOP-per-Watt ratio of modern GPUs. The architecture is highly parallel within and across nodes, with all major processing elements performed by GPUs. Necessary scatter-gather operations along the pipeline are loosely synchronized and implemented in MPI. The MWA will be a frontier scientific instrument and a pathfinder for planned peta- and exascale facilities.

  4. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing Tool Fits the Bill Financing ToolSustainableSecurityHighDepartment ofLight-Emitting Diode

  5. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E.

    2014-11-01

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ? 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, andmore »wavelength calibration.« less

  6. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera

    SciTech Connect (OSTI)

    Bell, Ronald E.

    2014-11-01

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ? 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  7. Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E

    2014-07-01

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  8. Development and operation of a high-throughput accurate-wavelength lens-based spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E.

    2014-11-15

    A high-throughput spectrometer for the 400–820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  9. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543, USA

    2014-11-01

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  10. Thicker, more efficient superconducting strip-line detectors for high throughput macromolecules analysis

    SciTech Connect (OSTI)

    Casaburi, A.; Ejrnaes, M.; Cristiano, R.; Zen, N.; Ohkubo, M.; Pagano, S.

    2011-01-10

    Fast detectors with large area are required in time-of-flight mass spectrometers for high throughput analysis of biological molecules. We fabricated and characterized subnanosecond 1x1 mm{sup 2} NbN superconducting strip-line detectors. The influence of the strip-line thickness on the temporal characteristics and efficiency of the detector for the impacts of keV accelerated molecules is investigated. We find that the increase of thickness improves both efficiency and response time. In the thicker sample we achieved a rise time of 380 ps, a fall time of 1.38 ns, and a higher count rate. The physics involved in this behavior is investigated.

  11. Metalloproteomics: High-Throughput Structural and Functional Annotation of Proteins in Structural Genomics

    SciTech Connect (OSTI)

    Shi,W.; Zhan, C.; Lgnatov, A.; Manjasetty, B.; Marinkovic, N.; Sullivan, M.; Huang, R.; Chance, M.; Li, H.; et al.

    2005-01-01

    A high-throughput method for measuring transition metal content based on quantitation of X-ray fluorescence signals was used to analyze 654 proteins selected as targets by the New York Structural GenomiX Research Consortium. Over 10% showed the presence of transition metal atoms in stoichiometric amounts; these totals as well as the abundance distribution are similar to those of the Protein Data Bank. Bioinformatics analysis of the identified metalloproteins in most cases supported the metalloprotein annotation; identification of the conserved metal binding motif was also shown to be useful in verifying structural models of the proteins. Metalloproteomics provides a rapid structural and functional annotation for these sequences and is shown to be {approx}95% accurate in predicting the presence or absence of stoichiometric metal content. The project's goal is to assay at least 1 member from each Pfam family; approximately 500 Pfam families have been characterized with respect to transition metal content so far.

  12. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    SciTech Connect (OSTI)

    Cuttitta, Christina M.; Ericson, Daniel L.; Scalia, Alexander; Roessler, Christian G.; Teplitsky, Ella; Joshi, Karan; Campos, Olven; Agarwal, Rakhi; Allaire, Marc; Orville, Allen M.; Sweet, Robert M.; Soares, Alexei S.

    2015-01-01

    An acoustic high-throughput screening method is described for harvesting protein crystals and combining the protein crystals with chemicals such as a fragment library. Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s{sup ?1}) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.

  13. been the key to their success is the use of high-throughput experiments to assess various zeo-

    E-Print Network [OSTI]

    Silver, Whendee

    it and the resulting pore structure. It could be that the hexamethonium molecules pack in such a way as to providebeen the key to their success is the use of high- throughput experiments to assess various zeo and shape of the resulting pores cor- responds to the size and shape of the organic molecule. ITQ-33

  14. Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway

    E-Print Network [OSTI]

    Wu, Kai Connie; McDonald, Peter R.; Liu, Jie Jerry; Chaguturu, Rathnam; Klaassen, Curtis D.

    2012-10-08

    of these genes. To identify Nrf2 activators for the treatment of oxidative/electrophilic stress-induced diseases, the present study developed a high-throughput assay to evaluate Nrf2 activation using AREc32 cells that contain a luciferase gene under the control...

  15. PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei and Aleksandar Kavcic

    E-Print Network [OSTI]

    Kavcic, Aleksandar

    PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei performance close to the channel capacity limits. Deep pipelined architecture for the forward only method, where as FB-BCJR only allow sequential state metric computations. Parallelism facilitates pipelining, re

  16. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION Jeffrey Kingyens and J. Gregory Steffan

    E-Print Network [OSTI]

    Steffan, J. Gregory

    ) is realizable on an XtremeData XD1000 FPGA-based accelerator system, we demonstrate that our soft processor can in the scientific, financial, and other data-driven arenas that will use them. Developing an accelerator designA GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION Jeffrey Kingyens and J. Gregory

  17. Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio computations

    E-Print Network [OSTI]

    Ceder, Gerbrand

    Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio (>700 Wh/kg) cathode materials for lithium-ion batteries. 1 Introduction The widespread use of lithium compounds. Testing previously known lithium-containing compounds for battery properties can lead

  18. A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies

    E-Print Network [OSTI]

    Peterson, Kenneth R.; Costa, Flá via C.; Fedosyuk, Halyna; Neades, Renee Y.; Chazelle, Allen M.; Zelenchuk, Lesya; Fonteles, Andrea H.; Dalal, Parmita; Roy, Anuradha; Chaguturu, Rathnam; Li, Biaoru; Pace, Betty S.

    2014-09-16

    , with minimal off-target effects, continues to be an elusive goal. One hurdle has been an assay amenable to a high-throughput screen (HTS) of chemicals that displays a robust c-globin off-on switch to identify potential lead compounds. Assay systems developed...

  19. On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets

    SciTech Connect (OSTI)

    Kusne, AG; Gao, TR; Mehta, A; Ke, LQ; Nguyen, MC; Ho, KM; Antropov, V; Wang, CZ; Kramer, MJ; Long, C; Takeuchi, I

    2014-09-15

    Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.

  20. High-throughput liquid-absorption air-sampling apparatus and methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    2000-01-01

    A portable high-throughput liquid-absorption air sampler [PHTLAAS] has an asymmetric air inlet through which air is drawn upward by a small and light-weight centrifugal fan driven by a direct current motor that can be powered by a battery. The air inlet is so configured as to impart both rotational and downward components of motion to the sampled air near said inlet. The PHTLAAS comprises a glass tube of relatively small size through which air passes at a high rate in a swirling, highly turbulent motion, which facilitates rapid transfer of vapors and particulates to a liquid film covering the inner walls of the tube. The pressure drop through the glass tube is <10 cm of water, usually <5 cm of water. The sampler's collection efficiency is usually >20% for vapors or airborne particulates in the 2-3.mu. range and >50% for particles larger than 4.mu.. In conjunction with various analyzers, the PHTLAAS can serve to monitor a variety of hazardous or illicit airborne substances, such as lead-containing particulates, tritiated water vapor, biological aerosols, or traces of concealed drugs or explosives.

  1. Metal Organic Framework Research: High Throughput Discovery of Robust Metal Organic Framework for CO2 Capture

    SciTech Connect (OSTI)

    None

    2010-08-01

    IMPACCT Project: LBNL is developing a method for identifying the best metal organic frameworks for use in capturing CO2 from the flue gas of coal-fired power plants. Metal organic frameworks are porous, crystalline compounds that, based on their chemical structure, vary considerably in terms of their capacity to grab hold of passing CO2 molecules and their ability to withstand the harsh conditions found in the gas exhaust of coal-fired power plants. Owing primarily to their high tunability, metal organic frameworks can have an incredibly wide range of different chemical and physical properties, so identifying the best to use for CO2 capture and storage can be a difficult task. LBNL uses high-throughput instrumentation to analyze nearly 100 materials at a time, screening them for the characteristics that optimize their ability to selectively adsorb CO2 from coal exhaust. Their work will identify the most promising frameworks and accelerate their large-scale commercial development to benefit further research into reducing the cost of CO2 capture and storage.

  2. Evaluation of a New Remote Handling Design for High Throughput Annular Centrifugal Contactors

    SciTech Connect (OSTI)

    David H. Meikrantz; Troy G. Garn; Jack D. Law; Lawrence L. Macaluso

    2009-09-01

    Advanced designs of nuclear fuel recycling plants are expected to include more ambitious goals for aqueous based separations including; higher separations efficiency, high-level waste minimization, and a greater focus on continuous processes to minimize cost and footprint. Therefore, Annular Centrifugal Contactors (ACCs) are destined to play a more important role for such future processing schemes. Previous efforts defined and characterized the performance of commercial 5 cm and 12.5 cm single-stage ACCs in a “cold” environment. The next logical step, the design and evaluation of remote capable pilot scale ACCs in a “hot” or radioactive environment was reported earlier. This report includes the development of remote designs for ACCs that can process the large throughput rates needed in future nuclear fuel recycling plants. Novel designs were developed for the remote interconnection of contactor units, clean-in-place and drain connections, and a new solids removal collection chamber. A three stage, 12.5 cm diameter rotor module has been constructed and evaluated for operational function and remote handling in highly radioactive environments. This design is scalable to commercial CINC ACC models from V-05 to V-20 with total throughput rates ranging from 20 to 650 liters per minute. The V-05R three stage prototype was manufactured by the commercial vendor for ACCs in the U.S., CINC mfg. It employs three standard V-05 clean-in-place (CIP) units modified for remote service and replacement via new methods of connection for solution inlets, outlets, drain and CIP. Hydraulic testing and functional checks were successfully conducted and then the prototype was evaluated for remote handling and maintenance suitability. Removal and replacement of the center position V-05R ACC unit in the three stage prototype was demonstrated using an overhead rail mounted PaR manipulator. This evaluation confirmed the efficacy of this innovative design for interconnecting and cleaning individual stages while retaining the benefits of commercially reliable ACC equipment for remote applications in the nuclear industry. Minor modifications and suggestions for improved manual remote servicing by the remote handling specialists were provided but successful removal and replacement was demonstrated in the first prototype.

  3. FELIX: a High-Throughput Network Approach for Interfacing to Front End Electronics for ATLAS Upgrades

    E-Print Network [OSTI]

    Anderson, John Thomas; The ATLAS collaboration; Boterenbrood, Hendrik; Chen, Hucheng; Chen, Kai; Drake, Gary; Francis, David; Gorini, Benedetto; Lanni, Francesco; Lehmann Miotto, Giovanna; Levinson, Lorne; Narevicius, Julia; Plessl, Christian; Roich, Alexander; Ryu, Soo; Schreuder, Frans Philip; Schumacher, Jorn; Vandelli, Wainer; Vermeulen, Jos; Zhang, Jinlong

    2015-01-01

    The ATLAS experiment at CERN is planning full deployment of a new unified optical link technology for connecting detector front end electronics on the timescale of the LHC Run 4 (2025). It is estimated that roughly 8000 GBT (GigaBit Transceiver) links, with transfer rates up to 10.24~Gbps, will replace existing links used for readout, detector control and distribution of timing and trigger information. A new class of devices will be needed to interface many GBT links to the rest of the trigger, data-acquisition and detector control systems. In this paper FELIX (Front End LInk eXchange) is presented, a PC-based device to route data from and to multiple GBT links via a high-performance general purpose network capable of a total throughput up to O(20 Tbps). FELIX implies architectural changes to the ATLAS data acquisition system, such as the use of industry standard COTS components early in the DAQ chain. Additionally the design and implementation of a FELIX demonstration platform is presented, and hardware and ...

  4. Anaerobic High-Throughput Cultivation Method for Isolation of Thermophiles Using Biomass-Derived Substrates

    SciTech Connect (OSTI)

    Hamilton-Brehm, Scott; Vishnivetskaya, Tatiana A; Allman, Steve L; Mielenz, Jonathan R; Elkins, James G

    2012-01-01

    Flow cytometry (FCM) techniques have been developed for sorting mesophilic organisms, but the difficulty increases if the target microbes are thermophilic anaerobes. We demonstrate a reliable, high-throughput method of screening thermophilic anaerobic organisms using FCM and 96-well plates for growth on biomass-relevant substrates. The method was tested using the cellulolytic thermophiles Clostridium ther- mocellum (Topt = 55 C), Caldicellulosiruptor obsidiansis (Topt = 78 C) and the fermentative hyperthermo- philes, Pyrococcus furiosus (Topt = 100 C) and Thermotoga maritima (Topt = 80 C). Multi-well plates were incubated at various temperatures for approximately 72 120 h and then tested for growth. Positive growth resulting from single cells sorted into individual wells containing an anaerobic medium was verified by OD600. Depending on the growth substrate, up to 80 % of the wells contained viable cultures, which could be transferred to fresh media. This method was used to isolate thermophilic microbes from Rabbit Creek, Yellowstone National Park (YNP), Wyoming. Substrates for enrichment cultures including crystalline cellulose (Avicel), xylan (from Birchwood), pretreated switchgrass and Populus were used to cultivate organisms that may be of interest to lignocellulosic biofuel production.

  5. Gasification of refuse derived fuel in the Battelle high throughput gasification system

    SciTech Connect (OSTI)

    Paisley, M.A.; Creamer, K.S.; Tweksbury, T.L.; Taylor, D.R. )

    1989-07-01

    This report presents the results of an experimental program to demonstrate the suitability of the Battelle High Throughput Gasification Process to non-wood biomass fuels. An extensive data base on wood gasification was generated during a multi-year experimental program. This data base and subsequent design and economic analysis activities led to the discussion to study the gasification character of other fuels. The specific fuel studied was refuse derived fuel (RDF) which is a prepared municipal solid waste (MSW). The use of RDF, while providing a valuable fuel, can also provide a solution to MSW disposal problems. Gasification of MSW provides advantages over land fill or mass burn technology since a more usable form of energy, medium Btu gas, is produced. Land filling of wastes produces no usable products and mass burning while greatly reducing the volume of wastes for disposal can produce only steam. This steam must be used on site or very nearby this limiting the potential locations for mass burn facilities. Such a gas, if produced from currently available supplies of MSW, can contribute 2 quads to the US energy supply. 3 refs., 12 figs., 7 tabs.

  6. A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science

    SciTech Connect (OSTI)

    Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.

    2013-04-01

    We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 10×10 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.

  7. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  8. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care

    E-Print Network [OSTI]

    Clarke, Angus J.; Cooper, David N.; Krawczak, Michael; Tyler-Smith, Chris; Wallace, Helen M.; Wilkie, Andrew O. M.; Raymond, Frances L.; Chadwick, Ruth; Craddock, Nick; John, Ros; Gallacher, John; Chiano, Mathias

    2012-08-02

    and ageing), and in response to environmental challenges (diet, stress). To this end, a number of ingenious genome-wide, high- throughput technologies have been developed. Some are based on the ability to selectively capture methylated fragments of the genome... consumes too much energy or mis- conceived arguments lead to the inappropriate applica- tion of theory in policy and practise across various walks of life, most especially psychiatry, education and the law. Second, and despite a full acceptance...

  9. Synthesis and characterization of four new metal 5-phosphonoisophthalates discovered by high-throughput experimentation

    SciTech Connect (OSTI)

    Bauer, Sebastian [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany); Stock, Norbert [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany)], E-mail: stock@ac.uni-kiel.de

    2007-11-15

    A new ligand, 5-diethylphosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2}, H{sub 2}Et{sub 2}L), for the hydrothermal synthesis of inorganic-organic hybrid compounds was prepared and characterized by NMR-spectroscopy. Its in situ hydrolysis leads to the corresponding 5-phosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H{sub 2}, H{sub 4}L). Applying high-throughput methods, different di- and trivalent metal salts for the synthesis of crystalline metal phosphonates based on H{sub 2}Et{sub 2}L have been screened. From the resulting discovery library, single-crystals of four new compounds, [Sm{sub 2}(H{sub 2}O){sub 4}(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (1), [Cu{sub 3}(H{sub 2}O)(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (2), Ca{sub 2}(H{sub 2}O)[H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H]{sub 2} (3), and Ba{sub 2}(H{sub 2}O){sub 3}(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3} (4), have been isolated. The single-crystal structure determination of the title compounds shows H{sub 4}L to be a versatile ligand, exhibiting different types of coordination modes between the functional groups and the metal ions. A comparison of the structural features of the title compounds shows a varying degree of M-O-M connectivities. Thus, isolated metal-oxygen clusters (compounds 1 and 2), infinite M-O-M chains (compound 3), and infinite M-O-M layers (compound 4) are observed. The title compounds 1, 2, and 3 were further characterized by IR-spectroscopy, TG-, EDX-, and elemental chemical analysis. - Graphical abstract: Applying high-throughput methods, the new ligand 5-diethylphosphonoisophtalic acid, (HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2} (H{sub 2}Et{sub 2}L), was reacted with several di- and trivalent metal salts under hydrothermal conditions. Single-crystals of four new inorganic-organic hybrid compounds were isolated from the discovery library. The single-crystal structure analysis shows a varying M-O-M connectivity.

  10. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cuttitta, Christina M.; Ericson, Daniel L.; Scalia, Alexander; Roessler, Christian G.; Teplitsky, Ella; Joshi, Karan; Campos, Olven; Agarwal, Rakhi; Allaire, Marc; Orville, Allen M.; et al

    2014-06-01

    Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s-1) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from themore »inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.« less

  11. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    SciTech Connect (OSTI)

    Cuttitta, Christina M.; Ericson, Daniel L.; Scalia, Alexander; Roessler, Christian G.; Teplitsky, Ella; Joshi, Karan; Campos, Olven; Agarwal, Rakhi; Allaire, Marc; Orville, Allen M.; Sweet, Robert M.; Soares, Alexei S.

    2014-06-01

    Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s-1) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.

  12. High-throughput two-hybrid analysis The promise and the peril

    E-Print Network [OSTI]

    Dunham, Maitreya

    , reduction in reagent costs and further refinements of the approach. As throughput escalates, so does use. The first stage is the initial description of a method: the prototype version. Typically. For a large fraction of new technologies, few other examples beyond this proto- type are ever described

  13. New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)

    ScienceCinema (OSTI)

    Notredame, Cedric [Centre for Genomic Regulation

    2011-06-08

    Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.

  14. Vehicle Technologies Office Merit Review 2015: High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems For Automotive Cast Magnesium Alloys

    Broader source: Energy.gov [DOE]

    Presentation given by Ohio State University at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high-throughput study...

  15. Interleaving techniques for high-throughput chaotic noise generation in CMOS

    E-Print Network [OSTI]

    Sergio Callegari; Riccardo Rovatti; Gianluca Setti

    2015-07-01

    An interleaving technique is proposed to enhance the throughput of current-mode CMOS discrete time chaotic sources based on the iteration of unidimensional maps. A discussion of the reasons and the advantages offered by the approach is provided, together with analytical results about the conservation of some major statistical features. As an example, application to an FM-DCSK communication system is proposed. To conclude, a sample circuit capable of 20 Msample/s is presented.

  16. High G MEMS integrated accelerometer

    SciTech Connect (OSTI)

    Davies, B.R.; Barron, C.C.; Montague, S.; Smith, J.H.; Murray, J.R.; Christenson, T.R.; Bateman, V.I.

    1996-12-31

    This paper describes the design and implementation of a surface micromachined accelerometer for measuring very high levels of acceleration (up to 50,000 G). Both the mechanical and electronic portions of the sensor were integrated on a single substrate using a process developed at Sandia National Laboratories. In this process, the mechanical components of the sensor were first fabricated at the bottom of a trench etched into the water substrate. The trench was then filled with oxide and sealed to protect the mechanical components during subsequent microelectronics processing. The wafer surface was then planarized in preparation for CMOS processing using Chemical Mechanical Polishing (CMP). Next, the CMOS electronics were fabricated on areas of the wafer adjacent to the embedded structures. Finally, the mechanical structures were released and the sensor tested. The mechanical structure of the sensor consisted of two polysilicon plate masses suspended by multiple springs (cantilevered beam structures) over corresponding polysilicon plates fixed to the substrate to form two parallel plate capacitors. The first polysilicon plate mass was suspended using compliant springs (cantilever beams) and acted as a variable capacitor during sensor acceleration. The second polysilicon plate mass was suspended using very stiff springs and acted as a fixed capacitor during acceleration. Acceleration was measured by comparing the capacitance of the variable capacitor (compliant suspension) with the fixed capacitance (stiff suspension).

  17. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect (OSTI)

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  18. A Bayesian Approach to Calibrating High-Throughput Virtual Screening Results and Application to Organic Photovoltaic Materials

    E-Print Network [OSTI]

    Pyzer-Knapp, Edward O; Aspuru-Guzik, Alan

    2015-01-01

    A novel approach for calibrating quantum-chemical properties determined as part of a high-throughput virtual screen to experimental analogs is presented. Information on the molecular graph is extracted through the use of extended connectivity fingerprints, and exploited using a Gaussian process to calibrate both electronic properties such as frontier orbital energies, and optical gaps and device properties such as short circuit current density, open circuit voltage and power conversion efficiency. The Bayesian nature of this process affords a value for uncertainty in addition to each calibrated value. This allows the researcher to gain intuition about the model as well as the ability to respect its bounds.

  19. High energy x-ray diffraction/x-ray fluorescence spectroscopy for high-throughput analysis of composition spread thin films

    SciTech Connect (OSTI)

    Gregoire, John M. [Department of Physics, and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Dale, Darren; Kazimirov, Alexander [Cornell High Energy Synchrotron Source, Cornell University, New York 14853 (United States); DiSalvo, Francis J. [Department of Chemistry and Chemical Biology, and Cornell Fuel Cell Institute, Cornell University, New York 14853 (United States); Dover, R. Bruce van [Department of Materials Science and Engineering, and Cornell Fuel Cell Institute, Cornell University, New York 14853 (United States)

    2009-12-15

    High-throughput crystallography is an important tool in materials research, particularly for the rapid assessment of structure-property relationships. We present a technique for simultaneous acquisition of diffraction images and fluorescence spectra on a continuous composition spread thin film using a 60 keV x-ray source. Subsequent noninteractive data processing provides maps of the diffraction profiles, thin film fiber texture, and composition. Even for highly textured films, our diffraction technique provides detection of diffraction from each family of Bragg reflections, which affords direct comparison of the measured profiles with powder patterns of known phases. These techniques are important for high throughput combinatorial studies as they provide structure and composition maps which may be correlated with performance trends within an inorganic library.

  20. RECENT PROCESS AND EQUIPMENT IMPROVEMENTS TO INCREASE HIGH LEVEL WASTE THROUGHPUT AT THE DEFENSE WASTE PROCESSING FACILITY

    SciTech Connect (OSTI)

    Odriscoll, R; Allan Barnes, A; Jim Coleman, J; Timothy Glover, T; Robert Hopkins, R; Dan Iverson, D; Jeff Leita, J

    2008-01-15

    The Savannah River Site's (SRS) Defense Waste Processing Facility (DWPF) began stabilizing high level waste (HLW) in a glass matrix in 1996. Over the past few years, there have been several process and equipment improvements at the DWPF to increase the rate at which the high level waste can be stabilized. These improvements have either directly increased waste processing rates or have desensitized the process to upsets, thereby minimizing downtime and increasing production. Improvements due to optimization of waste throughput with increased HLW loading of the glass resulted in a 6% waste throughput increase based upon operational efficiencies. Improvements in canister production include the pour spout heated bellows liner (5%), glass surge (siphon) protection software (2%), melter feed pump software logic change to prevent spurious interlocks of the feed pump with subsequent dilution of feed stock (2%) and optimization of the steam atomized scrubber (SAS) operation to minimize downtime (3%) for a total increase in canister production of 12%. A number of process recovery efforts have allowed continued operation. These include the off gas system pluggage and restoration, slurry mix evaporator (SME) tank repair and replacement, remote cleaning of melter top head center nozzle, remote melter internal inspection, SAS pump J-Tube recovery, inadvertent pour scenario resolutions, dome heater transformer bus bar cooling water leak repair and new Infra-red camera for determination of glass height in the canister are discussed.

  1. Risk-based high-throughput chemical screening and prioritization using exposure models and in vitro bioactivity assays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shin, Hyeong -Moo; Ernstoff, Alexi; Arnot, Jon A.; Wetmore, Barbara A.; Csiszar, Susan A.; Fantke, Peter; Zhang, Xianming; McKone, Thomas E.; Jolliet, Olivier; Bennett, Deborah H.

    2015-05-01

    We present a risk-based high-throughput screening (HTS) method to identify chemicals for potential health concerns or for which additional information is needed. The method is applied to 180 organic chemicals as a case study. We first obtain information on how the chemical is used and identify relevant use scenarios (e.g., dermal application, indoor emissions). For each chemical and use scenario, exposure models are then used to calculate a chemical intake fraction, or a product intake fraction, accounting for chemical properties and the exposed population. We then combine these intake fractions with use scenario-specific estimates of chemical quantity to calculate dailymore »intake rates (iR; mg/kg/day). These intake rates are compared to oral equivalent doses (OED; mg/kg/day), calculated from a suite of ToxCast in vitro bioactivity assays using in vitro-to-in vivo extrapolation and reverse dosimetry. Bioactivity quotients (BQs) are calculated as iR/OED to obtain estimates of potential impact associated with each relevant use scenario. Of the 180 chemicals considered, 38 had maximum iRs exceeding minimum OEDs (i.e., BQs > 1). For most of these compounds, exposures are associated with direct intake, food/oral contact, or dermal exposure. The method provides high-throughput estimates of exposure and important input for decision makers to identify chemicals of concern for further evaluation with additional information or more refined models.« less

  2. High-throughput, dual probe biological assays based on single molecule detection

    DOE Patents [OSTI]

    Hollars, Christopher W. (Brentwood, CA); Huser, Thomas R. (Livermore, CA); Lane, Stephen M. (Oakland, CA); Balhorn, Rodney L. (Livermore, CA); Bakajin, Olgica (San Leandro, CA); Darrow, Christopher (Pleasanton, CA); Satcher, Jr., Joe H. (Patterson, CA)

    2006-07-11

    A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 .mu.m.times.100 .mu.m.times.100 .mu.m. A device using these methods would have 10.sup.3 10.sup.4 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 .mu.m.sup.3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (.about.10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.

  3. SPATIALLY-SEPARATED ATOMIC LAYER DEPOSITION OF Al2O3, A NEW OPTION FOR HIGH-THROUGHPUT Si SOLAR CELL PASSIVATION

    E-Print Network [OSTI]

    SPATIALLY-SEPARATED ATOMIC LAYER DEPOSITION OF Al2O3, A NEW OPTION FOR HIGH-THROUGHPUT Si SOLAR material for surface passivation of crystalline Si is atomic layer deposited (ALD) Al2O3. However for the development of high-efficiency solar cells. It has been shown that atomic layer deposition (ALD) of Al2O3

  4. Industrial co-generation through use of a medium BTU gas from biomass produced in a high throughput reactor

    SciTech Connect (OSTI)

    Feldmann, H.F.; Ball, D.A.; Paisley, M.A.

    1983-01-01

    A high-throughput gasification system has been developed for the steam gasification of woody biomass to produce a fuel gas with a heating value of 475 to 500 Btu/SCF without using oxygen. Recent developments have focused on the use of bark and sawdust as feedstocks in addition to wood chips and the testing of a new reactor concept, the so-called controlled turbulent zone (CTZ) reactor to increase gas production per unit of wood fed. Operating data from the original gasification system and the CTZ system are used to examine the preliminary economics of biomass gasification/gas turbine cogeneration systems. In addition, a ''generic'' pressurized oxygen-blown gasification system is evaluated. The economics of these gasification systems are compared with a conventional wood boiler/steam turbine cogeneration system.

  5. Determination of gene expression patterns using high-throughput RNA in situ hybridizaion to whole-mount Drosophila embryos

    SciTech Connect (OSTI)

    Weiszmann, R.; Hammonds, A.S.; Celniker, S.E.

    2009-04-09

    We describe a high-throughput protocol for RNA in situ hybridization (ISH) to Drosophila embryos in a 96-well format. cDNA or genomic DNA templates are amplified by PCR and then digoxigenin-labeled ribonucleotides are incorporated into antisense RNA probes by in vitro transcription. The quality of each probe is evaluated before ISH using a RNA probe quantification (dot blot) assay. RNA probes are hybridized to fixed, mixed-staged Drosophila embryos in 96-well plates. The resulting stained embryos can be examined and photographed immediately or stored at 4oC for later analysis. Starting with fixed, staged embryos, the protocol takes 6 d from probe template production through hybridization. Preparation of fixed embryos requires a minimum of 2 weeks to collect embryos representing all stages. The method has been used to determine the expression patterns of over 6,000 genes throughout embryogenesis.

  6. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  7. Ultra-high Throughput Real-time Instruments for Capturing Fast Signals and Rare Events

    E-Print Network [OSTI]

    Buckley, Brandon Walter

    2013-01-01

    fiber; OSA: Optical spectrum analyzer; PD: Photo-detector;high-speed optical spectrum analyzer [60]. We call this1% tap on an optical spectrum analyzer (OSA). The resulting

  8. Integrated Solar Thermochemical Reaction System for High Efficiency...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Integrated Solar Thermochemical Reaction System for High Efficiency Production of Electricity Integrated Solar Thermochemical Reaction System for High Efficiency Production of...

  9. Development of high-capacity cathode materials with integrated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    high-capacity cathode materials with integrated structures Development of high-capacity cathode materials with integrated structures 2009 DOE Hydrogen Program and Vehicle...

  10. Development of High-Capacity Cathode Materials with Integrated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Publications Development of High-Capacity Cathode Materials with Integrated Structures Development of High-Capacity Cathode Materials with Integrated Structures...

  11. Development of High-Capacity Cathode Materials with Integrated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Publications Development of high-capacity cathode materials with integrated structures Development of High-Capacity Cathode Materials with Integrated Structures...

  12. High Efficiency Microturbine with Integral Heat Recovery - Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Efficiency Microturbine with Integral Heat Recovery - Presentation by Capstone Turbine Corporation, June 2011 High Efficiency Microturbine with Integral Heat Recovery -...

  13. High Efficiency Microturbine with Integral Heat Recovery - Fact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Efficiency Microturbine with Integral Heat Recovery - Fact Sheet, 2014 High Efficiency Microturbine with Integral Heat Recovery - Fact Sheet, 2014 Capstone Turbine...

  14. Development and operation of a high-throughput accurate-wavelength...

    Office of Scientific and Technical Information (OSTI)

    imaging. A precision optical encoder measures the grating angle with an accuracy 0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer...

  15. High-throughput screening of perovskite alloys for piezoelectric performance and thermodynamic stability

    E-Print Network [OSTI]

    Armiento, Rickard R.

    We screen a large chemical space of perovskite alloys for systems with optimal properties to accommodate a morphotropic phase boundary (MPB) in their composition-temperature phase diagram, a crucial feature for high ...

  16. AFLOW: An automatic framework for high-throughput materials discovery Stefano Curtarolo a,b,

    E-Print Network [OSTI]

    Curtarolo, Stefano

    , Denis O. Demchenko f , Dane Morgan g a Department of Mechanical Engineering and Materials Science, Duke Commonwealth University, Richmond, VA 23284, United States g Department of Materials Science and Engineering-optimization techniques used for the study of high-temperature reactions in multicomponent hydrides [29­31]. In its

  17. Applications of high throughput (combinatorial) methodologies to electronic, magnetic, optical, and energy-related materials

    E-Print Network [OSTI]

    Rubloff, Gary W.

    , and energy-related materials Martin L. Green, Ichiro Takeuchi, and Jason R. Hattrick-Simpers Citation: J) methodologies to electronic, magnetic, optical, and energy-related materials Martin L. Green,1 Ichiro Takeuchi,2 materials science for electronic, magnetic, optical, and energy-related materials. It is expected that high

  18. Air-stable ink for scalable, high-throughput layer deposition

    DOE Patents [OSTI]

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  19. Optical waveguides for microfluidic integration

    E-Print Network [OSTI]

    Ram, Rajeev J.

    A scalable polymer backplane for dense integration of photonics with lab-on-a-chip systems is presented. A high-throughput cell culture chip employing waveguides for monitoring and control of culture conditions is used to ...

  20. High-throughput film-densitometry: An efficient approach to generate large data sets

    SciTech Connect (OSTI)

    Typke, Dieter; Nordmeyer, Robert A.; Jones, Arthur; Lee, Juyoung; Avila-Sakar, Agustin; Downing, Kenneth H.; Glaeser, Robert M.

    2004-07-14

    A film-handling machine (robot) has been built which can, in conjunction with a commercially available film densitometer, exchange and digitize over 300 electron micrographs per day. Implementation of robotic film handling effectively eliminates the delay and tedium associated with digitizing images when data are initially recorded on photographic film. The modulation transfer function (MTF) of the commercially available densitometer is significantly worse than that of a high-end, scientific microdensitometer. Nevertheless, its signal-to-noise ratio (S/N) is quite excellent, allowing substantial restoration of the output to ''near-to-perfect'' performance. Due to the large area of the standard electron microscope film that can be digitized by the commercial densitometer (up to 10,000 x 13,680 pixels with an appropriately coded holder), automated film digitization offers a fast and inexpensive alternative to high-end CCD cameras as a means of acquiring large amounts of image data in electron microscopy.

  1. Scalable Computational Methods for the Analysis of High-Throughput Biological Data

    SciTech Connect (OSTI)

    Langston, Michael A

    2012-09-06

    This primary focus of this research project is elucidating genetic regulatory mechanisms that control an organism�¢����s responses to low-dose ionizing radiation. Although low doses (at most ten centigrays) are not lethal to humans, they elicit a highly complex physiological response, with the ultimate outcome in terms of risk to human health unknown. The tools of molecular biology and computational science will be harnessed to study coordinated changes in gene expression that orchestrate the mechanisms a cell uses to manage the radiation stimulus. High performance implementations of novel algorithms that exploit the principles of fixed-parameter tractability will be used to extract gene sets suggestive of co-regulation. Genomic mining will be performed to scrutinize, winnow and highlight the most promising gene sets for more detailed investigation. The overall goal is to increase our understanding of the health risks associated with exposures to low levels of radiation.

  2. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing Tool Fits the Bill Financing ToolSustainableSecurityHighDepartment ofLight-Emitting

  3. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls - Building America Topa High Binding Energy (New

  4. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls - Building America Topa High Binding

  5. High Efficiency Solar Integrated Roof Membrane Product

    SciTech Connect (OSTI)

    Partyka, Eric; Shenoy, Anil

    2013-05-15

    This project was designed to address the Solar Energy Technology Program objective, to develop new methods to integrate photovoltaic (PV) cells or modules within a building-integrated photovoltaic (BIPV) application that will result in lower installed cost as well as higher efficiencies of the encapsulated/embedded PV module. The technology assessment and development focused on the evaluation and identification of manufacturing technologies and equipment capable of producing such low-cost, high-efficiency, flexible BIPV solar cells on single-ply roofing membranes.

  6. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D. Title: Professor -|High energy neutronhigh

  7. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    SciTech Connect (OSTI)

    He, Zhili; Deng, Ye; Nostrand, Joy Van; Tu, Qichao; Xu, Meiying; Hemme, Chris; Wu, Liyou; Hazen, Terry; Zhou, Jizhong; Li, Xingyuan; Gentry, Terry; Yin, Yifeng; Liebich, Jost

    2010-05-17

    Microarray-based genomic technology has been widely used for microbial community analysis, and it is expected that microarray-based genomic technologies will revolutionize the analysis of microbial community structure, function and dynamics. A new generation of functional gene arrays (GeoChip 3.0) has been developed, with 27,812 probes covering 56,990 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance, and organic contaminant degradation. Those probes were derived from 2,744, 140, and 262 species for bacteria, archaea, and fungi, respectively. GeoChip 3.0 has several other distinct features, such as a common oligo reference standard (CORS) for data normalization and comparison, a software package for data management and future updating, and the gyrB gene for phylogenetic analysis. Our computational evaluation of probe specificity indicated that all designed probes had a high specificity to their corresponding targets. Also, experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036percent-0.025percent false positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which demonstrated that the structure, composition, and potential activity of soil microbial communities significantly changed with the plant species diversity. All results indicate that GeoChip 3.0 is a high throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning. To our knowledge, GeoChip 3.0 is the most comprehensive microarrays currently available for studying microbial communities associated with geobiochemical cycling, global climate change, bioenergy, agricuture, land use, ecosystem management, environmental cleanup and restoration, bioreactor systems, and human health.

  8. Conversion of forest residues to a methane-rich gas in a high-throughput gasifier

    SciTech Connect (OSTI)

    Feldmann, H.F.; Paisley, M.A.; Appelbaum, H.R.; Taylor, D.R.

    1988-05-01

    Research was conducted in a process research unit to develop an entrained bed gasifier which is supplied heat by recirculating a stream of sand between a separate combustion vessel and the gasifier. The char remaining after gasification of the wood provides the fuel for the combustor. The research program was conducted in two phases. In the first phase, a 6 in. I.D. gasifier was used to establish the feasibility of the concept for a wide variety of biomass feeds. The second phase of the program was conducted with a 10 in. I.D. gasifier, and a fully automated feeder system, to evaluate gasifier performance at very high feed rates. The experimental results were used to develop design parameters and detailed energy and material balances for a conceptual plant. A preliminary cost analysis is presented in the report based on the conceptual design. 5 refs., 24 figs., 13 tabs.

  9. High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis

    SciTech Connect (OSTI)

    Wenwan Zhong

    2003-08-05

    Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.

  10. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01

    the resulting fluid flow lies in the laminar flow regime andfluid flow at the microflu- idic scale was strictly laminar andof laminar flow is that mixing of two conjoin- ing fluids is

  11. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01

    P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev

  12. High Efficiency Microturbine with Integral Heat Recovery - Fact...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Efficiency Microturbine with Integral Heat Recovery - Fact Sheet, 2014 High Efficiency Microturbine with Integral Heat Recovery - Fact Sheet, 2014 Capstone Turbine Corporation, in...

  13. Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery

    SciTech Connect (OSTI)

    Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: ajhart@mit.edu [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-11-15

    Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called “Robofurnace.” Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.

  14. High throughput microcantilever detector

    DOE Patents [OSTI]

    Thundat, Thomas G.; Ferrell, Thomas L.; Hansen, Karolyn M.; Tian, Fang

    2004-07-20

    In an improved uncoated microcantilever detector, the sample sites are placed on a separate semi-conducting substrate and the microcantilever element detects and measures the changes before and after a chemical interaction or hybridization of the sites by sensing differences of phase angle between an alternating voltage applied to the microcantilever element and vibration of the microcantilever element. In another embodiment of the invention, multiple sample sites are on a sample array wherein an array of microcantilever elements detect and measure the change before and after chemical interactions or hybridizations of the sample sites.

  15. High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    E-Print Network [OSTI]

    Nieland, Thomas J.

    The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...

  16. High Throughput, Low Toxic Processing of Very Thin, High Efficiency CIGSS Solar Cells: Final Report, December 2008

    SciTech Connect (OSTI)

    Dhere, N. G.

    2009-04-01

    The work carried out during this project presents the use of diethylselenium or other organometallic precursors as low-toxicity alternative selenium sources for preparing a high-quality absorber.

  17. Data Integrity Limitations in Highly Secure Systems Cynthia E. Irvine

    E-Print Network [OSTI]

    Irvine, Cynthia E.

    or destruction." [14] A person who has integrity is identified as being one who acts based on a setData Integrity Limitations in Highly Secure Systems Cynthia E. Irvine Department of Computer that is higher in integrity than the integrity level of the COTS components. 1 Introduction Data integrity

  18. Development of High-Capacity Cathode Materials with Integrated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Publications Development of High-Capacity Cathode Materials with Integrated Structures Vehicle Technologies Office Merit Review 2015: Design and Evaluation of High...

  19. High Temperature Integrated Thermoelectric Ststem and Materials

    SciTech Connect (OSTI)

    Mike S. H. Chu

    2011-06-06

    The final goal of this project is to produce, by the end of Phase II, an all ceramic high temperature thermoelectric module. Such a module design integrates oxide ceramic n-type, oxide ceramic p-type materials as thermoelectric legs and oxide ceramic conductive material as metalizing connection between n-type and p-type legs. The benefits of this all ceramic module are that it can function at higher temperatures (> 700 C), it is mechanically and functionally more reliable and it can be scaled up to production at lower cost. With this all ceramic module, millions of dollars in savings or in new opportunities recovering waste heat from high temperature processes could be made available. A very attractive application will be to convert exhaust heat from a vehicle to reusable electric energy by a thermoelectric generator (TEG). Phase I activities were focused on evaluating potential n-type and p-type oxide compositions as the thermoelectric legs. More than 40 oxide ceramic powder compositions were made and studied in the laboratory. The compositions were divided into 6 groups representing different material systems. Basic ceramic properties and thermoelectric properties of discs sintered from these powders were measured. Powders with different particles sizes were made to evaluate the effects of particle size reduction on thermoelectric properties. Several powders were submitted to a leading thermoelectric company for complete thermoelectric evaluation. Initial evaluation showed that when samples were sintered by conventional method, they had reasonable values of Seebeck coefficient but very low values of electrical conductivity. Therefore, their power factors (PF) and figure of merits (ZT) were too low to be useful for high temperature thermoelectric applications. An unconventional sintering method, Spark Plasma Sintering (SPS) was determined to produce better thermoelectric properties. Particle size reduction of powders also was found to have some positive benefits. Two composition systems, specifically 1.0 SrO - 0.8 x 1.03 TiO2 - 0.2 x 1.03 NbO2.5 and 0.97 TiO2 - 0.03 NbO2.5, have been identified as good base line compositions for n-type thermoelectric compositions in future module design. Tests of these materials at an outside company were promising using that company's processing and material expertise. There was no unique p-type thermoelectric compositions identified in phase I work other than several current cobaltite materials. Ca3Co4O9 will be the primary p-type material for the future module design until alternative materials are developed. BaTiO3 and rare earth titanate based dielectric compositions show both p-type and n-type behavior even though their electrical conductivities were very low. Further research and development of these materials for thermoelectric applications is planned in the future. A preliminary modeling and optimization of a thermoelectric generator (TEG) that uses the n-type 1.0 SrO - 1.03 x 0.8 TiO2 - 1.03 x 0.2 NbO2.5 was performed. Future work will combine development of ceramic powders and manufacturing expertise at TAM, development of SPS at TAM or a partner organization, and thermoelectric material/module testing, modeling, optimization, production at several partner organizations.

  20. Function Prediction for Hypothetical Proteins in Yeast Saccharomyces cerevisiae Using Multiple Sources of High-Throughput Data

    E-Print Network [OSTI]

    , we have developed GeneFAS (Gene Function Annotation System) using an integrated probabilistic method Address: Digital Biology Laboratory, Computer Science Department, 201 Engineering Building West of predicting functions of unannotated proteins by developing efficient and automated methods. Several

  1. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

    E-Print Network [OSTI]

    Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sanchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger S.-Y.

    2010-06-14

    with this cis-element. Using high-throughput sequencing, we analyzed genome-wide binding sites for the p53-RELA complex in diseased and control human hearts and found a significant overrepresentation of the STAT3 motif. We further determined that STAT3...

  2. Novel turbomachinery concepts for highly integrated airframe/propulsion systems

    E-Print Network [OSTI]

    Shah, Parthiv N

    2007-01-01

    Two novel turbomachinery concepts are presented as enablers to advanced flight missions requiring integrated airframe/propulsion systems. The first concept is motivated by thermal management challenges in low-to-high Mach ...

  3. Development of economically viable, highly integrated, highly modular SEGIS architecture.

    SciTech Connect (OSTI)

    Enslin, Johan; Hamaoui, Ronald; Gonzalez, Sigifredo; Haddad, Ghaith; Rustom, Khalid; Stuby, Rick; Kuran, Mohammad; Mark, Evlyn; Amarin, Ruba; Alatrash, Hussam; Bower, Ward Isaac; Kuszmaul, Scott S.; Sena-Henderson, Lisa; David, Carolyn; Akhil, Abbas Ali

    2012-03-01

    Initiated in 2008, the SEGIS initiative is a partnership involving the U.S. DOE, Sandia National Laboratories, private sector companies, electric utilities, and universities. Projects supported under the initiative have focused on the complete-system development of solar technologies, with the dual goal of expanding renewable PV applications and addressing new challenges of connecting large-scale solar installations in higher penetrations to the electric grid. Petra Solar, Inc., a New Jersey-based company, received SEGIS funds to develop solutions to two of these key challenges: integrating increasing quantities of solar resources into the grid without compromising (and likely improving) power quality and reliability, and moving the design from a concept of intelligent system controls to successful commercialization. The resulting state-of-the art technology now includes a distributed photovoltaic (PV) architecture comprising AC modules that not only feed directly into the electrical grid at distribution levels but are equipped with new functions that improve voltage stability and thus enhance overall grid stability. This integrated PV system technology, known as SunWave, has applications for 'Power on a Pole,' and comes with a suite of technical capabilities, including advanced inverter and system controls, micro-inverters (capable of operating at both the 120V and 240V levels), communication system, network management system, and semiconductor integration. Collectively, these components are poised to reduce total system cost, increase the system's overall value and help mitigate the challenges of solar intermittency. Designed to be strategically located near point of load, the new SunWave technology is suitable for integration directly into the electrical grid but is also suitable for emerging microgrid applications. SunWave was showcased as part of a SEGIS Demonstration Conference at Pepco Holdings, Inc., on September 29, 2011, and is presently undergoing further field testing as a prelude to improved and expanded commercialization.

  4. Abstract--Design aspects of a minimally invasive high-throughput automation system for radiation biodosimetry are

    E-Print Network [OSTI]

    biodosimetry are reported. The system, currently under development, relies on robotic devices and advanced high of the automation system is proposed based on the use of an input stage, a centrifuge module, a cell harvesting

  5. High-throughput behavioral phenotyping of drug and alcohol susceptibility traits in the expanded panel of BXD recombinant inbred strains

    SciTech Connect (OSTI)

    Philip, Vivek M [ORNL; Ansah, T [University of Tennessee Health Science Center, Memphis; Blaha, C, [University of Tennessee Health Science Center, Memphis; Cook, Melloni N. [University of Memphis; Hamre, Kristin M. [University of Tennessee Health Science Center, Memphis; Lariviere, William R [University of Pittsburgh; Matthews, Douglas B [Baylor University; Goldowitz, Daniel [University of British Columbia, Vancouver; Chesler, Elissa J [ORNL

    2010-01-01

    Genetic reference populations, particularly the BXD recombinant inbred strains, are a valuable resource for the discovery of the bio-molecular substrates and genetic drivers responsible for trait variation and co- ariation. This approach can be profitably applied in the analysis of susceptibility and mechanisms of drug and alcohol use disorders for which many predisposing behaviors may predict occurrence and manifestation of increased preference for these substances. Many of these traits are modeled by common mouse behavioral assays, facilitating the detection of patterns and sources of genetic co-regulation of predisposing phenotypes and substance consumption. Members of the Tennessee Mouse Genome Consortium have obtained behavioral phenotype data from 260 measures related to multiple behavioral assays across several domains: self-administration, response to, and withdrawal from cocaine, MDMA, morphine and alcohol; novelty seeking; behavioral despair and related neurological phenomena; pain sensitivity; stress sensitivity; anxiety; hyperactivity; and sleep/wake cycles. All traits have been measured in both sexes and the recently expanded panel of 69 additional BXD recombinant inbred strains (N=69). Sex differences and heritability estimates were obtained for each trait, and a comparison of early (N = 32) and recent BXD RI lines was performed. Primary data is publicly available for heritability, sex difference and genetic analyses using www.GeneNetwork.org. These analyses include QTL detection and genetic analysis of gene expression. Stored results from these analyses are available at http://ontologicaldiscovery.org for comparison to other genomic analysis results. Together with the results of related studies, these data form a public resource for integrative systems genetic analysis of neurobehavioral traits.

  6. HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay

    SciTech Connect (OSTI)

    Labrecque, Jean; Metz, Markus; Lau, Gloria; Darkes, Marilyn C.; Wong, Rebecca S.Y.; Bogucki, David; Carpenter, Bryon; Chen Gang; Li Tongshuang; Nan, Susan; Schols, Dominique; Bridger, Gary J.; Fricker, Simon P.; Skerlj, Renato T.

    2011-05-10

    Based on the attrition rate of CCR5 small molecule antagonists in the clinic the discovery and development of next generation antagonists with an improved pharmacology and safety profile is necessary. Herein, we describe a combined molecular modeling, CCR5-mediated cell fusion, and receptor site-directed mutagenesis approach to study the molecular interactions of six structurally diverse compounds (aplaviroc, maraviroc, vicriviroc, TAK-779, SCH-C and a benzyloxycarbonyl-aminopiperidin-1-yl-butane derivative) with CCR5, a coreceptor for CCR5-tropic HIV-1 strains. This is the first study using an antifusogenic assay, a model of the interaction of the gp120 envelope protein with CCR5. This assay avoids the use of radioactivity and HIV infection assays, and can be used in a high throughput mode. The assay was validated by comparison with other established CCR5 assays. Given the hydrophobic nature of the binding pocket several binding models are suggested which could prove useful in the rational drug design of new lead compounds.

  7. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    SciTech Connect (OSTI)

    Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott

    2014-09-30

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled “Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.” The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSep® supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  8. Velo and REXAN - Integrated Data Management and High Speed Analysis for Experimental Facilities

    SciTech Connect (OSTI)

    Kleese van Dam, Kerstin; Carson, James P.; Corrigan, Abigail L.; Einstein, Daniel R.; Guillen, Zoe C.; Heath, Brandi S.; Kuprat, Andrew P.; Lanekoff, Ingela T.; Lansing, Carina S.; Laskin, Julia; Li, Dongsheng; Liu, Yan; Marshall, Matthew J.; Miller, Erin A.; Orr, Galya; Pinheiro da Silva, Paulo; Ryu, Seun; Szymanski, Craig J.; Thomas, Mathew

    2013-01-10

    The Chemical Imaging Initiative at the Pacific Northwest National Laboratory (PNNL) is creating a ‘Rapid Experimental Analysis’ (REXAN) Framework, based on the concept of reusable component libraries. REXAN allows developers to quickly compose and customize high throughput analysis pipelines for a range of experiments, as well as supporting the creation of multi-modal analysis pipelines. In addition, PNNL has coupled REXAN with its collaborative data management and analysis environment Velo to create an easy to use data management and analysis environments for experimental facilities. This paper will discuss the benefits of Velo and REXAN in the context of three examples: PNNL High Resolution Mass Spectrometry - reducing analysis times from hours to seconds, and enabling the analysis of much larger data samples (100KB to 40GB) at the same time · ALS X-Ray tomography - reducing analysis times of combined STXM and EM data collected at the ALS from weeks to minutes, decreasing manual work and increasing data volumes that can be analysed in a single step ·Multi-modal nano-scale analysis of STXM and TEM data - providing a semi automated process for particle detection The creation of REXAN has significantly shortened the development time for these analysis pipelines. The integration of Velo and REXAN has significantly increased the scientific productivity of the instruments and their users by creating easy to use data management and analysis environments with greatly reduced analysis times and improved analysis capabilities.

  9. A case study for cloud based high throughput analysis of NGS data using the globus genomics system

    SciTech Connect (OSTI)

    Bhuvaneshwar, Krithika; Sulakhe, Dinanath; Gauba, Robinder; Rodriguez, Alex; Madduri, Ravi; Dave, Utpal; Lacinski, Lukasz; Foster, Ian; Gusev, Yuriy; Madhavan, Subha

    2015-01-01

    Next generation sequencing (NGS) technologies produce massive amounts of data requiring a powerful computational infrastructure, high quality bioinformatics software, and skilled personnel to operate the tools. We present a case study of a practical solution to this data management and analysis challenge that simplifies terabyte scale data handling and provides advanced tools for NGS data analysis. These capabilities are implemented using the “Globus Genomics” system, which is an enhanced Galaxy workflow system made available as a service that offers users the capability to process and transfer data easily, reliably and quickly to address end-to-end NGS analysis requirements. The Globus Genomics system is built on Amazon's cloud computing infrastructure. The system takes advantage of elastic scaling of compute resources to run multiple workflows in parallel and it also helps meet the scale-out analysis needs of modern translational genomics research.

  10. A case study for cloud based high throughput analysis of NGS data using the globus genomics system

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bhuvaneshwar, Krithika; Sulakhe, Dinanath; Gauba, Robinder; Rodriguez, Alex; Madduri, Ravi; Dave, Utpal; Lacinski, Lukasz; Foster, Ian; Gusev, Yuriy; Madhavan, Subha

    2015-01-01

    Next generation sequencing (NGS) technologies produce massive amounts of data requiring a powerful computational infrastructure, high quality bioinformatics software, and skilled personnel to operate the tools. We present a case study of a practical solution to this data management and analysis challenge that simplifies terabyte scale data handling and provides advanced tools for NGS data analysis. These capabilities are implemented using the “Globus Genomics” system, which is an enhanced Galaxy workflow system made available as a service that offers users the capability to process and transfer data easily, reliably and quickly to address end-to-end NGS analysis requirements. The Globus Genomicsmore »system is built on Amazon's cloud computing infrastructure. The system takes advantage of elastic scaling of compute resources to run multiple workflows in parallel and it also helps meet the scale-out analysis needs of modern translational genomics research.« less

  11. Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling

    SciTech Connect (OSTI)

    Valerio, Luis G. . E-mail: luis.valerio@FDA.HHS.gov; Arvidson, Kirk B.; Chanderbhan, Ronald F.; Contrera, Joseph F.

    2007-07-01

    Consistent with the U.S. Food and Drug Administration (FDA) Critical Path Initiative, predictive toxicology software programs employing quantitative structure-activity relationship (QSAR) models are currently under evaluation for regulatory risk assessment and scientific decision support for highly sensitive endpoints such as carcinogenicity, mutagenicity and reproductive toxicity. At the FDA's Center for Food Safety and Applied Nutrition's Office of Food Additive Safety and the Center for Drug Evaluation and Research's Informatics and Computational Safety Analysis Staff (ICSAS), the use of computational SAR tools for both qualitative and quantitative risk assessment applications are being developed and evaluated. One tool of current interest is MDL-QSAR predictive discriminant analysis modeling of rodent carcinogenicity, which has been previously evaluated for pharmaceutical applications by the FDA ICSAS. The study described in this paper aims to evaluate the utility of this software to estimate the carcinogenic potential of small, organic, naturally occurring chemicals found in the human diet. In addition, a group of 19 known synthetic dietary constituents that were positive in rodent carcinogenicity studies served as a control group. In the test group of naturally occurring chemicals, 101 were found to be suitable for predictive modeling using this software's discriminant analysis modeling approach. Predictions performed on these compounds were compared to published experimental evidence of each compound's carcinogenic potential. Experimental evidence included relevant toxicological studies such as rodent cancer bioassays, rodent anti-carcinogenicity studies, genotoxic studies, and the presence of chemical structural alerts. Statistical indices of predictive performance were calculated to assess the utility of the predictive modeling method. Results revealed good predictive performance using this software's rodent carcinogenicity module of over 1200 chemicals, comprised primarily of pharmaceutical, industrial and some natural products developed under an FDA-MDL cooperative research and development agreement (CRADA). The predictive performance for this group of dietary natural products and the control group was 97% sensitivity and 80% concordance. Specificity was marginal at 53%. This study finds that the in silico QSAR analysis employing this software's rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity. It is the first study to demonstrate successful QSAR predictive modeling of naturally occurring carcinogens found in the human diet using an external validation test. Further test validation of this software and expansion of the training data set for dietary chemicals will help to support the future use of such QSAR methods for screening and prioritizing the risk of dietary chemicals when actual animal data are inadequate, equivocal, or absent.

  12. BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments

    SciTech Connect (OSTI)

    Round, Adam, E-mail: around@embl.fr; Felisaz, Franck [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Fodinger, Lukas; Gobbo, Alexandre [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Huet, Julien [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Villard, Cyril [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Blanchet, Clement E., E-mail: around@embl.fr [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Pernot, Petra; McSweeney, Sean [ESRF, 6 Rue Jules Horowitz, 38000 Grenoble (France); Roessle, Manfred; Svergun, Dmitri I. [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Cipriani, Florent, E-mail: around@embl.fr [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France)

    2015-01-01

    A robotic sample changer for solution X-ray scattering experiments optimized for speed and to use the minimum amount of material has been developed. This system is now in routine use at three high-brilliance European synchrotron sites, each capable of several hundred measurements per day. Small-angle X-ray scattering (SAXS) of macromolecules in solution is in increasing demand by an ever more diverse research community, both academic and industrial. To better serve user needs, and to allow automated and high-throughput operation, a sample changer (BioSAXS Sample Changer) that is able to perform unattended measurements of up to several hundred samples per day has been developed. The Sample Changer is able to handle and expose sample volumes of down to 5 µl with a measurement/cleaning cycle of under 1 min. The samples are stored in standard 96-well plates and the data are collected in a vacuum-mounted capillary with automated positioning of the solution in the X-ray beam. Fast and efficient capillary cleaning avoids cross-contamination and ensures reproducibility of the measurements. Independent temperature control for the well storage and for the measurement capillary allows the samples to be kept cool while still collecting data at physiological temperatures. The Sample Changer has been installed at three major third-generation synchrotrons: on the BM29 beamline at the European Synchrotron Radiation Facility (ESRF), the P12 beamline at the PETRA-III synchrotron (EMBL@PETRA-III) and the I22/B21 beamlines at Diamond Light Source, with the latter being the first commercial unit supplied by Bruker ASC.

  13. High Temperature, High Voltage Fully Integrated Gate Driver Circuit |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High HIGHofWasteDepartment of

  14. High Temperature, High Voltage Fully Integrated Gate Driver Circuit |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High HIGHofWasteDepartment

  15. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01

    60 4.2.5 Lubricant and Overcoats63 Figure 4.10: Scheme of lubricant durability65 Figure 4.11: Three lubricant flying tests at different

  16. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01

    heating Module..FH Control and Resist Pre-heating Module Inspired by thecontrol and resist pre-heating module using the same laser

  17. Biochemical & Thermochemical High Throughput Characterization...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    20 40 60 80 100 120 140 32 34 36 38 40 42 44 46 48 50 52 54 56 58 60 62 64 66 68 70 Frequency Corn Stover Corn Cob Miscanthus Wheat...

  18. Combinatorial Chemistry & High Throughput Screening, 2001, 4, 661-673 661 AnEvolutionaryApproachfor Structure-based Design of Natural and Non-

    E-Print Network [OSTI]

    Caflisch, Amedeo

    EvolutionaryApproachfor Structure-based Design of Natural and Non- natural Peptidic Ligands Nicolas Budin, Shaheen Ahmed, Nicolas- throughput homology modelling [4] are providing a large amount of targets for structure-based drug design-8057 Zürich, Switzerland Abstract: A new computational approach (PEP) is presented for the structure

  19. 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web-based High-Throughput Tool for Next-Generation Sequence Annotation

    E-Print Network [OSTI]

    320 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web deployed on the Mana Linux cluster at the Maui High Performance Computing Center. The two components

  20. Throughput of proportional fair scheduling over Rayleigh fading channels

    E-Print Network [OSTI]

    Leung, Kin K.

    Throughput of proportional fair scheduling over Rayleigh fading channels E. Liu and K.K. Leung The proportional fair scheduling (PFS) algorithm is implemented in current 3G wireless networks for high data rate of proportional fairness is NP-hard. An analytical expression is obtained to approximate the throughput of PFS

  1. Achieving High Reliability Operations Through Multi-Program Integration

    SciTech Connect (OSTI)

    Holly M. Ashley; Ronald K. Farris; Robert E. Richards

    2009-04-01

    Over the last 20 years the Idaho National Laboratory (INL) has adopted a number of operations and safety-related programs which has each periodically taken its turn in the limelight. As new programs have come along there has been natural competition for resources, focus and commitment. In the last few years, the INL has made real progress in integrating all these programs and are starting to realize important synergies. Contributing to this integration are both collaborative individuals and an emerging shared vision and goal of the INL fully maturing in its high reliability operations. This goal is so powerful because the concept of high reliability operations (and the resulting organizations) is a masterful amalgam and orchestrator of the best of all the participating programs (i.e. conduct of operations, behavior based safety, human performance, voluntary protection, quality assurance, and integrated safety management). This paper is a brief recounting of the lessons learned, thus far, at the INL in bringing previously competing programs into harmony under the goal (umbrella) of seeking to perform regularly as a high reliability organization. In addition to a brief diagram-illustrated historical review, the authors will share the INL’s primary successes (things already effectively stopped or started) and the gaps yet to be bridged.

  2. Design, Implementation and Performance of Exponential Integrators for High Performance Computing Applications

    E-Print Network [OSTI]

    Loffeld, John

    2013-01-01

    interest in high performance computing would help popularizeIntegrators for High Performance Computing Applications Aapplied mathematics, high performance computing and computer

  3. Highly parallel vector visualization using line integral convolution

    SciTech Connect (OSTI)

    Cabral, B.; Leedom, C.

    1995-12-01

    Line Integral Convolution (LIC) is an effective imaging operator for visualizing large vector fields. It works by blurring an input image along local vector field streamlines yielding an output image. LIC is highly parallelizable because it uses only local read-sharing of input data and no write-sharing of output data. Both coarse- and fine-grained implementations have been developed. The coarse-grained implementation uses a straightforward row-tiling of the vector field to parcel out work to multiple CPUs. The fine-grained implementation uses a series of image warps and sums to compute the LIC algorithm across the entire vector field at once. This is accomplished by novel use of high-performance graphics hardware texture mapping and accumulation buffers.

  4. High-Level Liquid Waste Tank Integrity Workshop - 2008

    Office of Environmental Management (EM)

    techniques for primarysecondary tank wall and concrete * * Develop tank integrity roadmap and execution plan Develop tank integrity roadmap and execution plan including...

  5. A New Look at the High Frequency Boundary Element and Rayleigh Integral Approximations

    E-Print Network [OSTI]

    Seybert, Andrew F.

    03NVC-114 A New Look at the High Frequency Boundary Element and Rayleigh Integral Approximations D of Automotive Engineers, Inc. ABSTRACT This paper revisits the popular Rayleigh integral approximation, and also to the Rayleigh integral. Both methods are approximations to the boundary integral equation, and can solve

  6. Print-based Manufacturing of Integrated, Low Cost, High Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (L3) Integrated Optimized * Electronics (PCB, Driver, LED's) * Heatsink * Housing * Optics On Track to meet Project End Goal Next Steps Equipment readiness , Process validation,...

  7. High order Chin actions in path integral Monte Carlo

    SciTech Connect (OSTI)

    Sakkos, K.; Casulleras, J.; Boronat, J.

    2009-05-28

    High order actions proposed by Chin have been used for the first time in path integral Monte Carlo simulations. Contrary to the Takahashi-Imada action, which is accurate to the fourth order only for the trace, the Chin action is fully fourth order, with the additional advantage that the leading fourth-order error coefficients are finely tunable. By optimizing two free parameters entering in the new action, we show that the time step error dependence achieved is best fitted with a sixth order law. The computational effort per bead is increased but the total number of beads is greatly reduced and the efficiency improvement with respect to the primitive approximation is approximately a factor of 10. The Chin action is tested in a one-dimensional harmonic oscillator, a H{sub 2} drop, and bulk liquid {sup 4}He. In all cases a sixth-order law is obtained with values of the number of beads that compare well with the pair action approximation in the stringent test of superfluid {sup 4}He.

  8. Incremental Development of a High Integrity Compiler: experience from an industrial development

    E-Print Network [OSTI]

    Stepney, Susan

    @logica.com Abstract We have developed and successfully applied a tech- nique to build a high integrity compiler from code into object code. We have developed and successfully applied this tech- nique to build a high of our tech- nique of using Z specication and Prolog implemen- tation to implement a high integrity

  9. High Efficiency Current-Mode Class-DAmplifier with Integrated Resonator

    E-Print Network [OSTI]

    Asbeck, Peter M.

    THIF-54 High Efficiency Current-Mode Class-DAmplifier with Integrated Resonator Tsai-PiHung, Andre) amplifiers with integrated parallel LC resonator can achieve high efficiency at RF frequencies. In contrast to implement a high Q inductor in the LC resonator. An experimental CMCD amplifier with collector efficiency

  10. Integrated Ground Motion and Tsunami Simulation for the 1944 Tonankai Earthquake Using High-Performance Supercomputers

    E-Print Network [OSTI]

    Furumura, Takashi

    Integrated Ground Motion and Tsunami Simulation for the 1944 Tonankai Earthquake Using High-Performance Supercomputers Paper: Dr4-2-3680; 2009/4/13 Integrated Ground Motion and Tsunami Simulation for the 1944 Tonankai.u-tokyo.ac.jp [Received December 23, 2009; accepted February 4, 2009] An integrated simulation of seismic wave and tsunami

  11. High Efficiency, Ultra-Low Emission, Integrated Process Heater System

    SciTech Connect (OSTI)

    Mason, Howard; Boral, Anindya; Chhotray, San; Martin, Matthew

    2006-06-19

    The team of TIAX LLC, ExxonMobil Research and Engineering Company, and Callidus Technologies, LLC conducted a six-year program to develop an ultra-low emission process heater burner and an advanced high efficiency heater design. This project addresses the critical need of process heater operators for reliable, economical emission reduction technologies to comply with stringent emission regulations, and for heater design alternatives that reduce process heater energy requirements without significant cost increase. The key project targets were NOx emissions of 10 ppm (@ 3% O2), and a heater thermal efficiency of 95 percent. The ultra low NOx burner was developed through a series of pilot-scale and field tests combined with computational fluid dynamic modeling to arrive at simultaneous low emissions and suitable flame shape and stability. Pilot scale tests were run at TIAX, at the 2 MMBtu/hr scale, and at Callidus at 8 MMBtu/hr. The full scale burner was installed on a 14 burner atmospheric pipestill furnace at an ExxonMobil refinery. A variety of burner configurations, gas tips and flame stabilizers were tested to determine the lowest emissions with acceptable flame shape and stability. The resulting NOx emissions were 22 ppm on average. Starting in 2001, Callidus commercialized the original ultra low NOx burner and made subsequent design improvements in a series of commercial burners evolving from the original concept and/or development. Emissions in the field with the ultra low-NOx burner over a broad spectrum of heater applications have varied from 5 ppm to 30 ppm depending on heater geometry, heater service, fuel and firing capacity. To date, 1550 of the original burners, and 2500 of subsequent generation burners have been sold by Callidus. The advanced heater design was developed by parametric evaluations of a variety of furnace and combustion air preheater configurations and technologies for enhancing convective and radiative heat transfer. The design evolution relied heavily on computational fluid dynamic predictions of design alternatives. The final design features modular separate radiant cells, each with one and two-side fired vertical tubes. The convection section configuration is vertical tube banks enclosed in the radiant channels. Commercial modular plate air preheaters are used. The predicted performance for the integrated advanced heater and Callidus burner is 95 percent efficiency with 9 ppm NOx emissions firing natural gas, and 12 ppm firing refinery gas. The total erected cost is less than a conventional heater with combustion air preheat.

  12. Analog integrated circuit design techniques for high-speed signal processing in communications systems 

    E-Print Network [OSTI]

    Hernandez Garduno, David

    2009-05-15

    This work presents design techniques for the implementation of high-speed analog integrated circuits for wireless and wireline communications systems. Limitations commonly found in high-speed switched-capacitor (SC) circuits used for intermediate...

  13. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

    1998-01-01

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

  14. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, L.O.; Ohta, Kazuyoshi; Wood, B.E.

    1998-10-13

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol. 13 figs.

  15. Recombinant cells that highly express chromosomally-integrated heterologous gene

    DOE Patents [OSTI]

    Ingram, Lonnie O.; Ohta, Kazuyoshi; Wood, Brent E.

    2007-03-20

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

  16. Recombinant cells that highly express chromosomally-integrated heterologous genes

    DOE Patents [OSTI]

    Ingram, Lonnie O. (Gainesville, FL); Ohta, Kazuyoshi (Gainesville, FL); Wood, Brent E. (Gainesville, FL)

    2000-08-22

    Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide encoded by that segment, relative to production of each polypeptide by the host cells in the absence of the mutation. The increased expression thus achieved is retained in the absence of conditions that select for cells displaying such increased expression. When the integrated segment comprises, for example, ethanol-production genes from an efficient ethanol producer like Zymomonas mobilis, recombinant Escherichia coli and other enteric bacterial cells within the present invention are capable of converting a wide range of biomass-derived sugars efficiently to ethanol.

  17. Integrated high efficiency blower apparatus for HVAC systems

    DOE Patents [OSTI]

    Liu, Xiaoyue; Weigman, Herman; Wang, Shixiao

    2007-07-24

    An integrated centrifugal blower wheel for a heating, ventilation and air conditioning (HVAC) blower unit includes a first blade support, a second blade support, and a plurality of S-shaped blades disposed between the first and second blade supports, wherein each of the S-shaped blades has a trailing edge bent in a forward direction with respect to a defined direction of rotation of the wheel.

  18. Efficient Algebraic Representations for Throughput-Oriented Algorithms

    E-Print Network [OSTI]

    McKinlay, Christopher E.

    2013-01-01

    Algorithm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Algorithm . . . . . . . . . . . . . . . . . . . . . . . . . . . .Throughput-Oriented Algorithm Design Multilinear

  19. Data Integration for the Generation of High Resolution Reservoir Models

    SciTech Connect (OSTI)

    Albert Reynolds; Dean Oliver; Gaoming Li; Yong Zhao; Chaohui Che; Kai Zhang; Yannong Dong; Chinedu Abgalaka; Mei Han

    2009-01-07

    The goal of this three-year project was to develop a theoretical basis and practical technology for the integration of geologic, production and time-lapse seismic data in a way that makes best use of the information for reservoir description and reservoir performance predictions. The methodology and practical tools for data integration that were developed in this research project have been incorporated into computational algorithms that are feasible for large scale reservoir simulation models. As the integration of production and seismic data require calibrating geological/geostatistical models to these data sets, the main computational tool is an automatic history matching algorithm. The following specific goals were accomplished during this research. (1) We developed algorithms for calibrating the location of the boundaries of geologic facies and the distribution of rock properties so that production and time-lapse seismic data are honored. (2) We developed and implemented specific procedures for conditioning reservoir models to time-lapse seismic data. (3) We developed and implemented algorithms for the characterization of measurement errors which are needed to determine the relative weights of data when conditioning reservoir models to production and time-lapse seismic data by automatic history matching. (4) We developed and implemented algorithms for the adjustment of relative permeability curves during the history matching process. (5) We developed algorithms for production optimization which accounts for geological uncertainty within the context of closed-loop reservoir management. (6) To ensure the research results will lead to practical public tools for independent oil companies, as part of the project we built a graphical user interface for the reservoir simulator and history matching software using Visual Basic.

  20. Integrated seal for high-temperature electrochemical device

    DOE Patents [OSTI]

    Tucker, Michael C; Jacobson, Craig P

    2013-07-16

    The present invention provides electrochemical device structures having integrated seals, and methods of fabricating them. According to various embodiments the structures include a thin, supported electrolyte film with the electrolyte sealed to the support. The perimeter of the support is self-sealed during fabrication. The perimeter can then be independently sealed to a manifold or other device, e.g., via an external seal. According to various embodiments, the external seal does not contact the electrolyte, thereby eliminating the restrictions on the sealing method and materials imposed by sealing against the electrolyte.

  1. Integrated coherent receivers for high-linearity microwave photonic links

    E-Print Network [OSTI]

    2008-01-01

    down sampling of wideband microwave signals,” J. Lightw.tunable MMI coupler for microwave photonic circuits,” inReceivers for High-Linearity Microwave Photonic Links Anand

  2. INTEGRATION OF HIGH TEMPERATURE GAS REACTORS WITH IN SITU OIL SHALE RETORTING

    SciTech Connect (OSTI)

    Eric P. Robertson; Michael G. McKellar; Lee O. Nelson

    2011-05-01

    This paper evaluates the integration of a high-temperature gas-cooled reactor (HTGR) to an in situ oil shale retort operation producing 7950 m3/D (50,000 bbl/day). The large amount of heat required to pyrolyze the oil shale and produce oil would typically be provided by combustion of fossil fuels, but can also be delivered by an HTGR. Two cases were considered: a base case which includes no nuclear integration, and an HTGR-integrated case.

  3. Quench propagation in High Temperature Superconducting materials integrated in high current leads

    E-Print Network [OSTI]

    Milani, D

    2001-01-01

    High temperature superconductors (HTS) have been integrated in the high current leads for the Large Hadron Collider (LHC), under construction at CERN, in order to reduce the heat leak into the liquid helium bath due to the joule effect. The use of the HTS technology in the lower part of the current leads allowed to significantly reduce the heat charge on the cryogenic system. Hybrid current leads have been designed to fulfill the LHC requirements with respect to thermal load; several tests have been performed to study the lead behavior especially during a quench transient. Quench experiments have been performed at CERN on 13 kA prototypes to determine the adequate design and protection. In all the tests it is possible to know the temperature profile of the HTS only with the help of quench simulations that model the thermo-hydraulic processes during quench. The development of a theoretical model for the simulation allows reducing the number of test to perform and to scale the experimental result to other curre...

  4. Delay and throughput analysis of tree algorithms for random access over noisy collision channels

    E-Print Network [OSTI]

    /FS was also combined with the binary exponential backoff (BEB) algorithm in [5] in an 802.16 setting of the BEB algorithm. Furthermore, [5] also indicated that the saturation throughput of SICTA/FS degrades quickly as the number of users increases, while BEB-SICTA/FS still achieves high throughputs

  5. Integration of High-Temperature Gas-Cooled Reactors into Industrial Process Applications

    SciTech Connect (OSTI)

    Lee Nelson

    2011-09-01

    This report is a summary of analyses performed by the NGNP project to determine whether it is technically and economically feasible to integrate high temperature gas cooled reactor (HTGR) technology into industrial processes. To avoid an overly optimistic environmental and economic baseline for comparing nuclear integrated and conventional processes, a conservative approach was used for the assumptions and calculations.

  6. Current mode integrators and their applications in low-voltage high frequency CMOS signal processing 

    E-Print Network [OSTI]

    Smith, Sterling Lane

    1993-01-01

    Low voltage CMOS fully differential integrators for high frequency continuous-time filters using current-mode techniques are presented.. Current mode techniques are employed to avoid the use of the floating differential ...

  7. High resolution reanalysis of wind speeds over the British Isles for wind energy integration 

    E-Print Network [OSTI]

    Hawkins, Samuel Lennon

    2012-11-29

    The UK has highly ambitious targets for wind development, particularly offshore, where over 30GW of capacity is proposed for development. Integrating such a large amount of variable generation presents enormous challenges. ...

  8. High Efficiency Microturbine with Integral Heat Recovery- Presentation by Capstone Turbine Corporation, June 2011

    Broader source: Energy.gov [DOE]

    Presentation on High Efficiency Microturbine with Integral Heat Recovery, given by John Nourse of Capstone Turbine Corporation, at the U.S. DOE Industrial Distributed Energy Portfolio Review Meeting in Washington, D.C. on June 1-2, 2011.

  9. High-speed silicon electro-optic modulator for electronic photonic integrated circuits

    E-Print Network [OSTI]

    Gan, Fuwan

    2007-01-01

    The development of future electronic-photonic integrated circuits (EPIC) based on silicon technology critically depends on the availability of CMOS-compatible high-speed modulators that enable the interaction of electronic ...

  10. Integrating radar stratigraphy with high resolution visible stratigraphy of the north polar layered deposits, Mars

    E-Print Network [OSTI]

    Byrne, Shane

    Integrating radar stratigraphy with high resolution visible stratigraphy of the north polar layered that radar reflectors can be used as geometric prox- ies for visible stratigraphy. Furthermore in the stratigraphy of the pola

  11. Correlated tuning of high-frequency integrated continuous-time filters 

    E-Print Network [OSTI]

    Brooks, Todd Lee

    1992-01-01

    CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis TODD LEE BROOKS Submitted to the Once of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1992 Major Subject: Electrical Engineering CORRELATED TUNING OF HIGH ? FREQUENCY INTEGRATED CONTINUOUS ? TIME FILTERS A Thesis by TODD LEE BROOKS Approved as to style and content by: Ran 11 L. Geiger (Co-Chair of Committee) William G...

  12. High Power Density Integrated Traction Machine Drive | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High HIGH PERFORMANCE and1 DOE

  13. High Power Density Integrated Traction Machine Drive | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡High HIGH PERFORMANCE and1 DOE0 DOE

  14. Princeton Power Systems (TRL 5 6 Component)- Marine High-Voltage Power Conditioning and Transmission System with Integrated Energy Storage

    Broader source: Energy.gov [DOE]

    Princeton Power Systems (TRL 5 6 Component) - Marine High-Voltage Power Conditioning and Transmission System with Integrated Energy Storage

  15. High performance CMOS integrated circuits for optical receivers 

    E-Print Network [OSTI]

    SamadiBoroujeni, MohammadReza

    2009-05-15

    .7GHz for a 0.6pF photodiode capacitance. The power dissipations for the highest and the lowest gains are 8.2mW and 24.9mW respectively. A new technique for designing uniform multistage amplifiers (MA) for high frequency applications is introduced...

  16. INTEGRAL and New Classes of High-Mass X-ray Binaries

    E-Print Network [OSTI]

    Christoph Winkler

    2007-12-04

    The gamma-ray observatory INTEGRAL, launched in October 2002, produces a wealth of discoveries and new results on compact high energy Galactic objects, nuclear gamma-ray line emission, diffuse line and continuum emission, cosmic background radiation, AGN and high energy transients. Two important serendipitous discoveries made by the INTEGRAL mission are new classes of X-ray binaries, namely the highly-obscured high-mass X-ray binaries, and the super-giant fast transients. In this paper I will review the current status of these discoveries.

  17. High Efficiency Microturbine with Integral Heat Recovery | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancing ProgramsDepartment of¡ ¢HelpHigh EfficiencyEnergy

  18. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, S.; Bozen, R.M.

    1992-12-22

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  19. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2014-10-14

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  20. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2012-09-11

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  1. A toolkit for high-throughput, cross-

    E-Print Network [OSTI]

    Cai, Long

    , Mihail Sarov, Sylke Winkler, Kamil A Lipinski & Pavel Tomancak We generated two complementary genomic. pseudoobscurab 88% 12% 0.12% 8.25% 3.65% Mapped clones (15,204 D.mel / 1,924 D.pse) Sequencing failures (1,426 D.mel / 142 D.pse) BLAST failures (20 D.mel / 1 D.pse) Chimeric clones (530 D.mel / 525 D.pse) 74% 26% 0.04% 5

  2. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D. Title: Professor -|

  3. Ensemble Jobs for Better Throughput - Videoconference | Argonne...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ensemble Jobs for Better Throughput - Videoconference Event Sponsor: Argonne National Laboratory Start Date: Sep 24 2015 - 1:00pm BuildingRoom: Online Videoconference Location:...

  4. High-Performance Multipanel Biosensors Based on a Selective Integration of Nanographite Petals

    E-Print Network [OSTI]

    De Micheli, Giovanni

    High-Performance Multipanel Biosensors Based on a Selective Integration of Nanographite Petals biosensor The simultaneous detection of endogenous and exogenous biocompounds is critically important biosensors with improved features.10 Finally, the CVD temperatures are too high (650-1200 °C) for the direct

  5. Extremely Bendable, High-Performance Integrated Circuits Using Semiconducting Carbon Nanotube Networks for Digital, Analog, and

    E-Print Network [OSTI]

    Javey, Ali

    -films of semiconduct- ing carbon nanotubes as the channel material for flexible electronics simultaneously offers high that our platform can serve as a foundation for scalable, low-cost, high-performance flexible electronics. KEYWORDS: Flexible electronics, thin-film transistors, semiconducting nanotube networks, integrated

  6. THE INTEGRAL EQUATION FOR A HIGH GAIN FEL N. A. Vinokurov *

    E-Print Network [OSTI]

    Kemner, Ken

    1 THE INTEGRAL EQUATION FOR A HIGH GAIN FEL N. A. Vinokurov * Introduction The theory of a high gain free electron laser (FEL) is now well developed (e.g., see [1]). In this paper I derive the equation for the electron distribution function, which is valid for FELs with a longitudinally

  7. High Efficancy Integrated Under-Cabinet Phosphorescent OLED

    SciTech Connect (OSTI)

    Michael Hack

    2001-10-31

    In this two year program Universal Display Corporation (UDC) together with the University of Michigan, Teknokon, developed and delivered an energy efficient phosphorescent OLED under cabinet illumination system. Specifically the UDC team goal was in 2011 to deliver five (5) Beta level OLED under cabinet lighting fixtures each consisting of five 6-inch x 6-inch OLED lighting panels, delivering over 420 lumens, at an overall system efficacy of >60 lm/W, a CRI of >85, and a projected lifetime to 70% of initial luminance to exceed 20,000 hours. During the course of this program, the Team pursued the commercialization of these OLED based under cabinet lighting fixtures, to enable the launch of commercial OLED lighting products. The UDC team was ideally suited to develop these novel and efficient solid state lighting fixtures, having both the technical experience and commercial distribution mechanisms to leverage work performed under this contract. UDC's business strategy is to non-exclusively license its PHOLED technology to lighting manufacturers, and also supply them with our proprietary PHOLED materials. UDC is currently working with several licensees who are manufacturing OLED lighting panels using our technology. During this 2 year program, we further developed our high efficiency white Phosphorescent OLEDs from the first milestone, achieving a 80 lm/W single pixel to the final milestone, achieving an under-cabinet PHOLED lighting system that operates at 56 lm/W at 420 lumens. Each luminaire was comprised of ten 15cm x 7.5cm lighting modules mounted in outcoupling enhancement lenses and a control module. The lamps modules are connected together using either plugs or wires with plugs on each end, allowing for unlimited configurations. The lamps are driven by an OLED driver mounted in an enclosure which includes the AC plug. As a result of advancements gained under this program, the path to move OLED lighting panels from development into manufacturing has been further realized. We have found that under-cabinet lighting is an ideal first entry product opportunity to launch OLED lighting for residential applications. From the studies that we have performed, our PHOLED under-cabinet lighting system performance is very similar to many of the current commercially available LED under-cabinet luminaires. We also found that the projected cost of PHOLED luminaire should be comparable to the LED luminaire by 2015. With the additional benefits of PHOLED lighting, no glare, better uniformity and low operating temperature, it can be easily seen how the PHOLED under-cabinet luminaire could be preferred over the LED competition. Although the metrics we set for this program were extremely aggressive, the performance we achieved and reported, represents a very significant advancement in the OLED lighting industry.

  8. INTEGRAL high energy sky: The keV to MeV cosmic sources

    E-Print Network [OSTI]

    P. Ubertini; A. De Rosa; A. Bazzano; L. Bassani; V. Sguera

    2008-02-03

    After almost 5 years of operation, ESA's International Gamma-Ray Astrophysics Laboratory (INTEGRAL) Space Observatory has unveiled a new soft Gamma ray sky and produced a remarkable harvest of results, ranging from identification of new high energy sources, to the discovery of dozens of variable sources to the mapping of the Aluminum emission from the Galaxy Plane to the presence of electrons and positrons generating the annihilation line in the Galaxy central radian. INTEGRAL is continuing the deep observations of the Galactic Plane and of the whole sky in the soft Gamma ray range. The new IBIS gamma ray catalogue contains more than 420 sources detected above 20 keV. We present a view of the INTEGRAL high energy sky with particular regard to sources emitting at high energy, including Active Galactic Nuclei (AGN), HESS/MAGIC counterparts and new view of the cosmic gamma ray diffuse background.

  9. On Achieving Optimal Throughput with Network Coding

    E-Print Network [OSTI]

    Li, Baochun

    to the problem of optimizing end-to- end throughput in undirected data networks. We first illustrate the powerOn Achieving Optimal Throughput with Network Coding Zongpeng Li, Baochun Li, Dan Jiang, Lap Chi Lau Abstract-- With the constraints of network topologies and link capacities, achieving the optimal end

  10. Open foundry platform for high-performance electronic-photonic integration

    E-Print Network [OSTI]

    Ram, Rajeev J.

    Open foundry platform for high-performance electronic-photonic integration Jason S. Orcutt,1 commercial electronic 45 nm SOI-CMOS foundry process. By utilizing existing front-end fabrication processes. Bogaerts, R. Baets, J. M. Fedeli, and L. Fulbert, "Towards foundry approach for silicon photonics: silicon

  11. High-Level Information An Approach for Integrating Front-End and Back-End Compilers

    E-Print Network [OSTI]

    Li, Zhiyuan

    High-Level Information ­ An Approach for Integrating Front-End and Back-End Compilers Sangyeun Cho-end and back-end compilers by passing front-end information to the back-end compiler. Importing this information into an existing back- end leverages the state-of-the-art analysis and transforma- tion

  12. A HIGH ORDER NYSTROM METHOD FOR BOUNDARY INTEGRAL EQUATIONS ON AXISYMMETRIC SURFACES

    E-Print Network [OSTI]

    Martinsson, Gunnar

    . Whenever f can be represented with a moderate number of Fourier modes, the trans- formation of (1.1) to (1. Key words. boundary integral equations, high order discretization, body of revolution AMS subject of uncoupled small linear systems (one for each Fourier mode). Since the system matrices are dense, the gain

  13. HAIL: A High-Availability and Integrity Layer for Cloud Storage

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    HAIL: A High-Availability and Integrity Layer for Cloud Storage Kevin D. Bowers RSA Laboratories imple- mentation. 1 Introduction Cloud storage denotes a family of increasingly popular on-line services for archiving, backup, and even primary storage of files. Amazon S3 [1] is a well known exam- ple. Cloud-storage

  14. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems (Extended Version)

    E-Print Network [OSTI]

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems (Extended Version links between devices in legacy Supervisory Con- trol And Data Acquisition (SCADA) systems, on which security, and yet incurs minimal end-to-end communication latency. Keywords: SCADA network security, bump

  15. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems

    E-Print Network [OSTI]

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems Patrick P. Tsang in Supervisory Control And Data Acquisition (SCADA) systems. Previous BITW solutions fail to provide@cs.dartmouth.edu #12;Contents 1 Introduction 3 1.1 SCADA Systems

  16. YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems

    E-Print Network [OSTI]

    Smith, Sean W.

    YASIR: A Low-Latency, High-Integrity Security Retrofit for Legacy SCADA Systems Patrick P. Tsang Supervisory Control And Data Acquisition (SCADA) systems, on which the proper operations of critical-to-end communication latency. 1 Introduction 1.1 SCADA Systems Supervisory Control And Data Acquisition (SCADA) systems

  17. Highly Integrated Millimeter-Wave Passive Components Using 3-D LTCC System-on-Package

    E-Print Network [OSTI]

    Tentzeris, Manos

    miniaturized easy-to-design passive circuits that can be used as critical building blocks for millimetre building blocks enabling a complete passive solution for compact, low cost wireless front-end modulesHighly Integrated Millimeter-Wave Passive Components Using 3-D LTCC System-on-Package (SOP

  18. High-efficiency photonic crystal microlaser integrated with a passive waveguide

    E-Print Network [OSTI]

    Baba, Toshihiko

    High-efficiency photonic crystal microlaser integrated with a passive waveguide Hideki Watanabe), Japan Science and Technology (JST) Agency, Sanbancho Building 5, Sanbancho, Tiyodaku, Tokyo 102 passive waveguide was fabricated by a MOCVD butt-joint regrowth process. The boundary between the active

  19. Inductive Characteristics of Power Distribution Grids in High Speed Integrated Circuits

    E-Print Network [OSTI]

    Friedman, Eby G.

    Inductive Characteristics of Power Distribution Grids in High Speed Integrated Circuits Andrey V characteristics of several types of gridded power distribution networks are described in this paper interconnect. In power distribution grids with alternating power and ground lines, the inductance is shown

  20. POWER AND SIGNAL INTEGRITY IMPROVEMENT IN ULTRA HIGH-SPEED CURRENT MODE LOGIC

    E-Print Network [OSTI]

    Brewer, Forrest D.

    for Low- Voltage-Swing Logic (LVSL) to greatly reduce the power require- ment of a CML logic subsystem% power reduction is achieved while improving the signal integrity. 1. INTRODUCTION High is that there is no viable power-conserving technology for multigi- gahertz logic in portable applications although

  1. Materials and Process Design for High-Temperature Carburizing: Integrating Processing and Performance

    SciTech Connect (OSTI)

    D. Apelian

    2007-07-23

    The objective of the project is to develop an integrated process for fast, high-temperature carburizing. The new process results in an order of magnitude reduction in cycle time compared to conventional carburizing and represents significant energy savings in addition to a corresponding reduction of scrap associated with distortion free carburizing steels.

  2. Structural integrity and potential failure modes of hanford high-level waste tanks

    SciTech Connect (OSTI)

    Han, F.C.

    1996-09-30

    Structural Integrity of the Hanford High-Level Waste Tanks were evaluated based on the existing Design and Analysis Documents. All tank structures were found adequate for the normal operating and seismic loads. Potential failure modes of the tanks were assessed by engineering interpretation and extrapolation of the existing engineering documents.

  3. A HIGH-FREQUENCY INTEGRAL EQUATION METHOD FOR ELECTROMAGNETIC AND ACOUSTIC SCATTERING SIMULATIONS : RATE OF CONVERGENCE OF MULTIPLE SCATTERING ITERATIONS

    E-Print Network [OSTI]

    Ecevit, Fatih

    A HIGH-FREQUENCY INTEGRAL EQUATION METHOD FOR ELECTROMAGNETIC AND ACOUSTIC SCATTERING SIMULATIONS an analysis of a recently proposed integral equation method for the solution of high-frequency elec properties of this series in the high-frequency regime depend solely on geometrical characteristics. Moreover

  4. Integrating High Penetrations of PV into Southern California: Year 2 Project Update; Preprint

    SciTech Connect (OSTI)

    Mather, B.; Neal, R.

    2012-08-01

    Southern California Edison (SCE) is well into a five-year project to install a total of 500 MW of distributed photovoltaic (PV) energy within its utility service territory. Typical installations to date are 1-3 MW peak rooftop PV systems that interconnect to medium-voltage urban distribution circuits or larger (5 MW peak) ground-mounted systems that connect to medium-voltage rural distribution circuits. Some of the PV system interconnections have resulted in distribution circuits that have a significant amount of PV generation compared to customer load, resulting in high-penetration PV integration scenarios. The National Renewable Energy Laboratory (NREL) and SCE have assembled a team of distribution modeling, resource assessment, and PV inverter technology experts in order to investigate a few of the high-penetration PV distribution circuits. Currently, the distribution circuits being studied include an urban circuit with a PV penetration of approximately 46% and a rural circuit with a PV penetration of approximately 60%. In both cases, power flow on the circuit reverses direction, compared to traditional circuit operation, during periods of high PV power production and low circuit loading. Research efforts during year two of the five-year project were focused on modeling the distribution system level impacts of high-penetration PV integrations, the development and installation of distribution circuit data acquisition equipment appropriate for quantifying the impacts of high-penetration PV integrations, and investigating high-penetration PV impact mitigation strategies. This paper outlines these research efforts and discusses the following activities in more detail: the development of a quasi-static time-series test feeder for evaluating high-penetration PV integration modeling tools; the advanced inverter functions being investigated for deployment in the project's field demonstration and a power hardware-in-loop test of a 500-kW PV inverter implementing a limited set of advanced inverter functions.

  5. High Performance Integrated Circuit Blocks for High-IF Wideband Receivers 

    E-Print Network [OSTI]

    Silva Rivas, Jose F.

    2010-07-14

    shaping to get fairly high resolution in a limited bandwidth. A major issue in continuous?time networks is the lack of accuracy due to powervoltage? temperature (PVT) tolerances that lead to over 20% pole variations compared to their discrete...

  6. Efficiency Analysis of a High Frequency Buck Converter for On-Chip Integration with a Dual-VDD Microprocessor

    E-Print Network [OSTI]

    Friedman, Eby G.

    Efficiency Analysis of a High Frequency Buck Converter for On-Chip Integration with a Dual that simultaneously permits monolithic integration and high efficiency. A parasitic model of the buck converter devices on the same die for a target technology. An efficiency of 88.4% at a switching frequency of 477

  7. An Integrated Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High-Frequency Drive

    E-Print Network [OSTI]

    Sanders, Seth

    An Integrated Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High Flywheel Energy Storage System with a Homopolar Inductor Motor/Generator and High-Frequency Drive Copyright 2003 by Perry I-Pei Tsao #12;1 Abstract An Integrated Flywheel Energy Storage System with a Homopolar

  8. A high-order fast method for computing convolution integral with smooth kernel

    E-Print Network [OSTI]

    Qiang, Ji

    2010-01-01

    of the convolution integral. The downside of these evenfor computing convolution integral with smooth kernel Jicalculate convolution integral with smooth non-periodic

  9. The development of a subsea high integrity pipeline protection system (HIPPS)

    SciTech Connect (OSTI)

    Frafjord, P.; Corneliussen, S.; Adriaansen, L.A.

    1995-12-31

    This paper considers the design criteria for a subsea High Integrity Pipeline pressure Protection System (HIPPS), which enables subsea pipelines to be designed for the operating, rather than the shut in wellhead pressure. Such systems will save considerable investment cost in the development of high pressure offshore oil and gas fields, particularly where the distance to the processing infrastructure is long. The conceptual design of a HIPPS which comprises two rapidly closing valves to protect the pipeline from over-pressure, is described. The reliability of the system is assessed and dynamic simulation of the valve and process flow are discussed.

  10. High Efficiency Optical MEMS by the Integration of Photonic Lattices with Surface MEMS

    SciTech Connect (OSTI)

    FLEMING, JAMES G.; LIN, SHAWN-YU; MANI, SEETHAMBAL S.; RODGERS, M. STEVEN; DAGEL, DARYL J.

    2002-11-01

    This report outlines our work on the integration of high efficiency photonic lattice structures with MEMS (MicroElectroMechanical Systems). The simplest of these structures were based on 1-D mirror structures. These were integrated into a variety of devices, movable mirrors, switchable cavities and finally into Bragg fiber structures which enable the control of light in at least 2 dimensions. Of these devices, the most complex were the Bragg fibers. Bragg fibers consist of hollow tubes in which light is guided in a low index media (air) and confined by surrounding Bragg mirror stacks. In this work, structures with internal diameters from 5 to 30 microns have been fabricated and much larger structures should also be possible. We have demonstrated the fabrication of these structures with short wavelength band edges ranging from 400 to 1600nm. There may be potential applications for such structures in the fields of integrated optics and BioMEMS. We have also looked at the possibility of waveguiding in 3 dimensions by integrating defects into 3-dimensional photonic lattice structures. Eventually it may be possible to tune such structures by mechanically modulating the defects.

  11. RADIATION CHEMISTRY OF HIGH ENERGY CARBON, NEON AND ARGON IONS: INTEGRAL YIELDS FROM FERROUS SULFATE SOLUTIONS

    E-Print Network [OSTI]

    Christman, E.A.

    2010-01-01

    NEON AND ARGON IONS: INTEGRAL YIELDS FROM FERROUS SULFATENEON AND ARGON IONS: INTEGRAL YIELDS FROM FERROUS SULFATE

  12. A pedagogical introduction to quantum integrability, with a view towards theoretical high-energy physics

    E-Print Network [OSTI]

    J. Lamers

    2015-06-03

    These are lecture notes of an introduction to quantum integrability given at the Tenth Modave Summer School in Mathematical Physics, 2014, aimed at PhD candidates and junior researchers in theoretical physics. We introduce spin chains and discuss the coordinate Bethe ansatz (CBA) for a representative example: the Heisenberg XXZ model. The focus lies on the structure of the CBA and on its main results, deferring a detailed treatment of the CBA for the general $M$-particle sector of the XXZ model to an appendix. Subsequently the transfer-matrix method is discussed for the six-vertex model, uncovering a relation between that model and the XXZ spin chain. Equipped with this background the quantum inverse-scattering method (QISM) and algebraic Bethe ansatz (ABA) are treated. We emphasize the use of graphical notation for algebraic quantities as well as computations. Finally we turn to quantum integrability in the context of theoretical high-energy physics. We discuss factorized scattering in two-dimensional QFT, and conclude with a qualitative introduction to one current research topic relating quantum integrability to theoretical high-energy physics: the Bethe/gauge correspondence.

  13. Current Activities Assessing Butt Fusion Joint Integrity in High Density Polyethylene Piping

    SciTech Connect (OSTI)

    Crawford, Susan L.; Cinson, Anthony D.; Doctor, Steven R.; Denslow, Kayte M.

    2012-09-01

    The Pacific Northwest National Laboratory (PNNL) in Richland, Washington, conducted initial studies to evaluate the effectiveness of nondestructive examinations (NDE) coupled with mechanical testing for assessing butt fusion joint integrity in high density polyethylene (HDPE) pipe. The work provided insightful information to the United States Nuclear Regulatory Commission (NRC) on the effectiveness of volumetric inspection techniques for detecting lack of fusion (LOF) conditions in the fusion joints. HDPE has been installed on a limited basis in American Society of Mechanical Engineers (ASME) Class 3, buried piping systems at several operating U.S. nuclear power plants and has been proposed for use in new construction. A comparison was made between the results from ultrasonic and microwave nondestructive examinations and the results from mechanical destructive evaluations, specifically the high-speed tensile test and the side-bend test, for determining joint integrity. The data comparison revealed that none of the NDE techniques detected all of the lack-of-fusion conditions that were revealed by the destructive tests. Follow-on work has recently been initiated at PNNL to accurately characterize the NDE responses from machined flaws of varying size and location in PE 4710 materials as well as the LOF condition. This effort is directed at quantifying the ability of volumetric NDE techniques to detect flaws in relation to the critical flaw size associated with joint integrity. A status of these latest investigations is presented.

  14. Models for the Configuration and Integrity of Partially Oxidized Fuel Rod Cladding at High Temperatures

    SciTech Connect (OSTI)

    Siefken, L.J.

    1999-01-01

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. These models are expected to improve the calculations of several important aspects of fuel rod behavior. First, an improved mapping was established from a compilation of PIE results from severe fuel damage tests of the configuration of melted metallic cladding that is retained by an oxide layer. The improved mapping accounts for the relocation of melted cladding in the circumferential direction. Then, rules based on PIE results were established for calculating the effect of cladding that has relocated from above on the oxidation and integrity of the lower intact cladding upon which it solidifies. Next, three different methods were identified for calculating the extent of dissolution of the oxidic part of the cladding due to its contact with the metallic part. The extent of dissolution effects the stress and thus the integrity of the oxidic part of the cladding. Then, an empirical equation was presented for calculating the stress in the oxidic part of the cladding and evaluating its integrity based on this calculated stress. This empirical equation replaces the current criterion for loss of integrity which is based on temperature and extent of oxidation. Finally, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The implementation of these models is expected to eliminate the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material. This report is a revision and reissue of the report entitled, Improvements in Modeling of Cladding Oxidation and Meltdown.

  15. Guidelines for development of structural integrity programs for DOE high-level waste storage tanks

    SciTech Connect (OSTI)

    Bandyopadhyay, K.; Bush, S.; Kassir, M.; Mather, B.; Shewmon, P.; Streicher, M.; Thompson, B.; Rooyen, D. van; Weeks, J.

    1997-01-01

    Guidelines are provided for developing programs to promote the structural integrity of high-level waste storage tanks and transfer lines at the facilities of the Department of Energy. Elements of the program plan include a leak-detection system, definition of appropriate loads, collection of data for possible material and geometric changes, assessment of the tank structure, and non-destructive examination. Possible aging degradation mechanisms are explored for both steel and concrete components of the tanks, and evaluated to screen out nonsignificant aging mechanisms and to indicate methods of controlling the significant aging mechanisms. Specific guidelines for assessing structural adequacy will be provided in companion documents. Site-specific structural integrity programs can be developed drawing on the relevant portions of the material in this document.

  16. Stable Throughput in a Cognitive Wireless Network

    E-Print Network [OSTI]

    Fanous, Anthony

    2012-01-01

    We study, from a network layer perspective, the effect of an Ad-Hoc secondary network with N nodes randomly accessing the spectrum licensed to a primary node during the idle slots of the primary user. If the sensing is perfect, then the secondary nodes do not interfere with the primary node and hence do not affect its stable throughput. In case of imperfect sensing, it is shown that if the primary user's arrival rate is less than some calculated finite value, cognitive nodes can employ any transmission power or probabilities without affecting the primary user's stability; otherwise, the secondary nodes should control their transmission parameters to reduce the interference on the primary. It is also shown that in contrast with the primary's maximum stable throughput which strictly decreases with increased sensing errors, the throughput of the secondary nodes might increase with sensing errors as more transmission opportunities become available to them. Finally, we explore the use of the secondary nodes as rel...

  17. Integrating INIS into a high energy physics information environment thoughts from CERN

    E-Print Network [OSTI]

    Yeomans, Joanne; Baudic, Romain; Picchioli, Ingrid; International Conference on Nuclear Knowledge Management : Strategies, Information Management and Human Resource Development. Special Session : The Role of INIS in Knowledge Preservation

    2004-01-01

    Information searchers from the high energy physics community expect an integrated information environment. The CERN Library offers its print and electronic collections through a combined Web interface and maintains the database by semi-automated processes to upload bibliographic and full-text records. Suggestions are offered by which INIS could develop its own Web interface and better match HEP users’ expectations. These include implementing full-text linking, increasing currency, expanding search and display functions and developing the richness of the data. Links with the National Nuclear Data Center and Crossref could also increase its visibility.

  18. Towards Fully Integrated High Temperature Wireless Sensors Using GaN-based HEMT Devices

    SciTech Connect (OSTI)

    Kuruganti, Phani Teja [ORNL; Islam, Syed K [ORNL; Huque, Mohammad A [ORNL

    2008-01-01

    Wireless sensors which are capable of working at extreme environments can significantly improve the efficiency and performance of industrial processes by facilitating better control systems. GaN, a widely researched wide bandgap material, has the potential to be used both as a sensing material and to fabricate control electronics, making it a prime candidate for high temperature integrated wireless sensor fabrication. In this paper we are presenting an experimental study on AlGaN/GaN HEMT's performance at higher temperature (up to 300 C). From test results, DC and microwave parameters at different temperatures were extracted.

  19. High-speed graphene interconnects monolithically integrated with CMOS ring oscillators operating at 1.3GHz

    E-Print Network [OSTI]

    Chen, Xiangyu

    We have successfully experimentally integrated graphene interconnects with commercial 0.25 Âżm technology CMOS ring oscillator circuit using conventional fabrication techniques, and demonstrated high speed on-chip graphene ...

  20. An overlay architecture for throughput optimal multipath routing

    E-Print Network [OSTI]

    Jones, Nathaniel M.

    Legacy networks are often designed to operate with simple single-path routing, like shortest-path, which is known to be throughput suboptimal. On the other hand, previously proposed throughput optimal policies (i.e., ...

  1. Throughput Analysis of Wireless Ad-Hoc Cognitive Radio Networks 

    E-Print Network [OSTI]

    Banaei, Armin

    2014-04-25

    In this dissertation we consider the throughput performance of cognitive radio networks and derive the optimal sensing and access schemes for secondary users that maximizes their sum-throughput while guaranteeing certain ...

  2. Throughput Maximization in Wireless Powered Communication Networks with Energy Saving

    E-Print Network [OSTI]

    Brown III, Donald R.

    Throughput Maximization in Wireless Powered Communication Networks with Energy Saving Rui Wang, D and energy allocation to maximize the sum throughput for the case when the nodes can save energy for later with energy saving provides improved sum throughput increasing with the number of transmission blocks. Index

  3. THE INTEGRAL HIGH-ENERGY CUT-OFF DISTRIBUTION OF TYPE 1 ACTIVE GALACTIC NUCLEI

    SciTech Connect (OSTI)

    Malizia, A.; Molina, M.; Bassani, L.; Stephen, J. B.; Bazzano, A.; Ubertini, P.; Bird, A. J.

    2014-02-20

    In this Letter we present the primary continuum parameters, the photon index ?, and the high-energy cut-off E {sub c} of 41 type-1 Seyfert galaxies extracted from the International Gamma-Ray Astrophysics Laboratory (INTEGRAL) complete sample of active galactic nuclei (AGNs). We performed broadband (0.3-100 keV) spectral analysis by simultaneously fitting the soft and hard X-ray spectra obtained by XMM and INTEGRAL/IBIS-Swift/BAT, respectively, in order to investigate the general properties of these parameters, in particular their distribution and mean values. We find a mean photon index of 1.73 with a standard deviation of 0.17 and a mean high-energy cut-off of 128 keV with a standard deviation of 46 keV for the whole sample. This is the first time that the cut-off energy is constrained in such a large number of AGNs. We have 26 measurements of the cut-off, which corresponds to 63% of the entire sample, distributed between 50 and 200 keV. There are a further 11 lower limits mostly below 300 keV. Using the main parameters of the primary continuum, we have been able to obtain the actual physical parameters of the Comptonizing region, i.e., the plasma temperature kT {sub e} from 20 to 100 keV and the optical depth ? < 4. Finally, with the high signal-to-noise ratio spectra starting to come from NuSTAR it will soon be possible to better constrain the cut-off values in many AGNs, allowing the determination of more physical models and thus better understand the continuum emission and geometry of the region surrounding black holes.

  4. It Takes Glue to Tango: MeDICi integration framework creates data-intensive computing pipeline

    SciTech Connect (OSTI)

    Gorton, Ian; Oehmen, Christopher S.; McDermott, Jason E.

    2008-11-01

    Biologists increasingly rely on high-performance computing (HPC) platforms to rapidly process the tsunami of data generated by high throughput genome and metagenome sequencing technology and high-throughput proteomics. Unfortunately, the platforms that produce the massive data sets rarely work smoothly with the interactive analysis and visualization programs used in bioinformatics. This makes it difficult for researchers to exploit the computational power of HPC platforms to speed scientific discovery. At the Department of Energy’s Pacific Northwest National Laboratory in Richland, Wash., researchers are creating computing environments for biologists that seamlessly integrate collections of data and computational resources. These advantages enable users to rapidly analyze high-throughput data. A major goal is to shield the biologist from the complexity of interacting with multiple dissimilar databases and running tasks on HPC platforms and computational clusters. One of those environments the MeDICi Integration Framework is now available for free download. Short for Middleware for Data-Intensive Computing, MeDICi makes it easy to integrate separate codes into complex applications that operate as a data analysis pipeline.

  5. A pedagogical introduction to quantum integrability, with a view towards theoretical high-energy physics

    E-Print Network [OSTI]

    Lamers, J

    2015-01-01

    These are lecture notes of an introduction to quantum integrability given at the Tenth Modave Summer School in Mathematical Physics, 2014, aimed at PhD candidates and junior researchers in theoretical physics. We introduce spin chains and discuss the coordinate Bethe Ansatz (CBA) for a representative example: the Heisenberg XXZ model. The focus lies on the structure of the CBA and on its main results, deferring a detailed treatment of the CBA for the general $M$-particle sector of the XXZ model to an appendix. Subsequently the transfer-matrix method is discussed for the six-vertex model, uncovering a relation between that model and the XXZ spin chain. Equipped with this background the quantum inverse-scattering method (QISM) and algebraic Bethe Ansatz (ABA) are treated. We emphasize the use of graphical notation for algebraic quantities as well as computations. Finally we turn to quantum integrability in the context of theoretical high-energy physics. We discuss factorized scattering in two-dimensional QFT, a...

  6. New hydrocracking catalysts increase throughput, run length

    SciTech Connect (OSTI)

    Huizinga, T. [Shell Internationale Petroleum Mij., The Hague (Netherlands); Theunissen, J.M.H. [Rayong Refinery Co. Ltd., Rayong (Thailand); Minderhoud, H.; Veen, R. van [Koninklijke/Shell-Lab., Amsterdam (Netherlands)

    1995-06-26

    An improved, second-stage hydrocracking catalyst has been developed by combining stabilized Y zeolites with amorphous silica alumina cracking components. A commercial application of this catalyst, along with a new, first-stage zeolitic hydrocracking catalyst, resulted in increased unit throughput and cycle length. The paper discusses the hydrocracking process, first-stage catalysts, second-stage catalysts, hydrogenation process, commercial results, and product properties.

  7. SCR-DPF Integrations for Diesel ExhaustPerformance and Perspectives for High SCR Loadings

    Broader source: Energy.gov [DOE]

    Presents laboratory and engine bench test results from integrating the SCR catalyst into the diesel filter as one multifunctional unit.

  8. Detecting the integrated Sachs-Wolfe effect with high-redshift 21-cm surveys

    E-Print Network [OSTI]

    Raccanelli, Alvise; Dai, Liang; Kamionkowski, Marc

    2015-01-01

    We investigate the possibility to detect the integrated Sachs-Wolfe (ISW) effect by cross-correlating 21-cm surveys at high redshifts with galaxies, in a way similar to the usual CMB-galaxy cross-correlation. The high-redshift 21-cm signal is dominated by CMB photons that travel freely without interacting with the intervening matter, and hence its late-time ISW signature should correlate extremely well with that of the CMB at its peak frequencies. Using the 21-cm temperature brightness instead of the CMB would thus be a further check of the detection of the ISW effect, measured by different instruments at different frequencies and suffering from different systematics. We also study the ISW effect on the photons that are scattered by HI clouds. We show that a detection of the unscattered photons is achievable with planned radio arrays, while one using scattered photons will require advanced radio interferometers, either an extended version of the planned Square Kilometre Array or futuristic experiments such as...

  9. Optimum Reactor Outlet Temperatures for High Temperature Gas-Cooled Reactors Integrated with Industrial Processes

    SciTech Connect (OSTI)

    Lee O. Nelson

    2011-04-01

    This report summarizes the results of a temperature sensitivity study conducted to identify the optimum reactor operating temperatures for producing the heat and hydrogen required for industrial processes associated with the proposed new high temperature gas-cooled reactor. This study assumed that primary steam outputs of the reactor were delivered at 17 MPa and 540°C and the helium coolant was delivered at 7 MPa at 625–925°C. The secondary outputs of were electricity and hydrogen. For the power generation analysis, it was assumed that the power cycle efficiency was 66% of the maximum theoretical efficiency of the Carnot thermodynamic cycle. Hydrogen was generated via the hightemperature steam electrolysis or the steam methane reforming process. The study indicates that optimum or a range of reactor outlet temperatures could be identified to further refine the process evaluations that were developed for high temperature gas-cooled reactor-integrated production of synthetic transportation fuels, ammonia, and ammonia derivatives, oil from unconventional sources, and substitute natural gas from coal.

  10. Parboil: A Revised Benchmark Suite for Scientific and Commercial Throughput Computing

    E-Print Network [OSTI]

    Hwu, Wen-mei W.

    are presented as challenges to the compiler and architecture research communities: to develop the technology Technical Report IMPACT-12-01 University of Illinois at Urbana-Champaign Center for Reliable and High computing applications useful for studying the performance of throughput computing architecture

  11. Stealthy Traffic Analysis of Low-Latency Anonymous Communication Using Throughput Fingerprinting

    E-Print Network [OSTI]

    Singh, Jaswinder Pal

    such as Tor aim to enable users to com- municate in a manner that is untraceable by adversaries that control this leaks in- formation about the set of Tor relays in a circuit (path). We present attacks that, with high the bottleneck relay of any Tor circuit whose throughput can be observed, (b) exactly identify the guard relay

  12. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01

    Independence & Security Act, Title XIII- Smart Grid, Sectiongrid operations Secure – integrated multi-faceted securityIndependence & Security act, Title XIII-Smart Grid, Section

  13. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01

    Integration of Intermittent Renewable Technologies Yih-huei,W. ; Parsons, B National Renewable Energy Laboratory, August2020: Towards a Policy of Renewable and Distributed Energy

  14. High Burn-Up Spent Nuclear Fuel Vibration Integrity Study 15134

    SciTech Connect (OSTI)

    Wang, Jy-An John; Wang, Hong; Jiang, Hao; Bevard, Bruce Balkcom; Howard, Rob L; Scaglione, John M

    2015-01-01

    The Oak Ridge National Laboratory (ORNL) has developed the cyclic integrated reversible-bending fatigue tester (CIRFT) approach to successfully demonstrate the controllable fatigue fracture on high burnup (HBU) spent nuclear fuel (SNF) in a normal vibration mode. CIRFT enables examination of the underlying mechanisms of SNF system dynamic performance. Due to the inhomogeneous composite structure of the SNF system, the detailed mechanisms of the pellet-pellet and pellet-clad interactions and the stress concentration effects at the pellet-pellet interface cannot be readily obtained from a CIRFT system measurement. Therefore, finite element analyses (FEAs) are used to translate the global moment-curvature measurement into local stress-strain profiles for further investigation. The major findings of CIRFT on the HBU SNF are as follows: SNF system interface bonding plays an important role in SNF vibration performance. Fuel structure contributes to SNF system stiffness. There are significant variations in stress and curvature of SNF systems during vibration cycles resulting from segment pellets and clad interactions. SNF failure initiates at the pellet-pellet interface region and appears to be spontaneous.

  15. Residential Buildings Integration (RBI)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7 RBI Priorities for FY15 and Beyond Integrating Advanced Technologies for Homes: * Building integrated renewables * IAQVentilation solutions * Integrated high performance...

  16. Vertically Grown Multiwalled Carbon Nanotube Anode and Nickel Silicide Integrated High Performance Microsized (1.25 L) Microbial

    E-Print Network [OSTI]

    Vertically Grown Multiwalled Carbon Nanotube Anode and Nickel Silicide Integrated High Performance multiwalled carbon nanotubes (MWCNTs) with a nickel silicide (NiSi) contact area that produced 197 mA/m2, carbon nanotube, nickel silicide, surface-to-volume ratio, power density Microbial fuel cells (MFCs

  17. High-Temperature SiC Power Module with Integrated SiC Gate Drivers for Future High-Density Power Electronics Applications

    SciTech Connect (OSTI)

    Whitaker, Mr. Bret [APEI, Inc.; Cole, Mr. Zach [APEI, Inc.; Passmore, Mr. Brandon [APEI, Inc.; Mcnutt, Tyler [APEI, Inc.; Lostetter, Dr. Alex [APEI, Inc.; Ericson, Milton Nance [ORNL; Frank, Steven [ORNL; Britton Jr, Charles L [ORNL; Marlino, Laura D [ORNL; Mantooth, Alan [University of Arkansas; Francis, Matt [APEI, Inc.; Lamichhane, Ranjan [APEI, Inc.; Shepherd, Paul [APEI, Inc.; Glover, Michael [APEI, Inc.

    2014-01-01

    This paper presents a high-temperature capable intelligent power module that contains SiC power devices and SiC gate driver integrated circuits (ICs). The high-temperature capability of the SiC gate driver ICs allows for them to be packaged into the power module and be located physically close to the power devices. This provides a distinct advantage by reducing the gate driver loop inductance, which promotes high frequency operation, while also reducing the overall volume of the system through higher levels of integration. The power module was tested in a bridgeless-boost converter (Fig. 1) to determine the performance of the module in a system level application. The converter was operated with a switching frequency of 200 kHz with a peak output power of approximately 5 kW. The peak efficiency was found to be 97.5% at 2.9 kW.

  18. Integration of pentacene-based thin film transistors via photolithography for low and high voltage applications

    E-Print Network [OSTI]

    Smith, Melissa Alyson

    2012-01-01

    An organic thin film transistor (OTFT) technology platform has been developed for flexible integrated circuits applications. OTFT performance is tuned by engineering the dielectric constant of the gate insulator and the ...

  19. An Integrated Formal Approach for Developing High Quality Software for Safety-Critical Systems

    E-Print Network [OSTI]

    Ouyang, Meng

    This report presents the results of a study which devises an Integrated Formal Approach (IFA) for improving specifications of the designs of computer programs used in safety-critical systems. In this IFA, the formal ...

  20. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01

    Workshop on Renewable Energy Costs for the 2012 Integrated renewable portfolio standards (RPS) and energy efficiency goals in a costcost of installing rooftop solar panels. While the renewable energy

  1. Development of an Advanced Approach for Next Generation, High Resolution, Integrated Reservoir Characterization

    SciTech Connect (OSTI)

    Scott R. Reeves

    2003-08-01

    During this reporting period work on Task 4: Develop Integrated Engineering Model was completed, incorporating the results from Log Clustering. A series of Topical Reports were prepared on Seismic Data Processing, Rock Physics modeling, Log Clustering, and the Integrated Engineering Model. These Topical Reports have been submitted to the test site field operator for review before submission to NETL staff in Tulsa. Work continues on development of the Broadband Seismic Transform Function.

  2. Sandia National Laboratories: Advanced Simulation and Computing: Integrated

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-ThroughputUpcoming Release of the UniversityValidationCodes Integrated Codes

  3. Maximizing the Sustained Throughput of Distributed Continuous Queries

    E-Print Network [OSTI]

    Palpanas, Themis

    the query plans that maximize throughput and adhere to the input profile. Examples of data stream managementMaximizing the Sustained Throughput of Distributed Continuous Queries Ioana Stanoi, George Mihaila of execution time for every incoming data tuple, which leads to an upper bound on the rate at which tuples can

  4. NREL/SCE High-Penetration PV Integration Project: Report on Field Demonstration of Advanced Inverter Functionality in Fontana, CA

    SciTech Connect (OSTI)

    Mather, B.

    2014-08-01

    The National Renewable Energy Laboratory/Southern California Edison High-Penetration PV Integration Project is (1) researching the distribution system level impacts of high-penetration photovoltaic (PV) integration, (2) determining mitigation methods to reduce or eliminate those impacts, and (3) seeking to demonstrate these mitigation methods on actual high-penetration PV distribution circuits. This report describes a field demonstration completed during the fall of 2013 on the Fontana, California, study circuit, which includes a total of 4.5 MW of interconnected utility-scale rooftop PV systems. The demonstration included operating a 2-MW PV system at an off-unity power factor that had been determined during previously completed distribution system modeling and PV impact assessment analyses. Data on the distribution circuit and PV system operations were collected during the 2-week demonstration period. This demonstration reinforces the findings of previous laboratory testing that showed that utility-scale PV inverters are capable of operating at off-unity power factor to mitigate PV impacts; however, because of difficulties setting and retaining PV inverter power factor set points during the field demonstration, it was not possible to demonstrate the effectiveness of off-unity power factor operation to mitigate the voltage impacts of high-penetration PV integration. Lessons learned from this field demonstration are presented to inform future field demonstration efforts.

  5. Method and apparatus for maximizing throughput of indirectly heated rotary kilns

    DOE Patents [OSTI]

    Coates, Ralph L; Smoot, L. Douglas; Hatfield, Kent E

    2012-10-30

    An apparatus and method for achieving improved throughput capacity of indirectly heated rotary kilns used to produce pyrolysis products such as shale oils or coal oils that are susceptible to decomposition by high kiln wall temperatures is disclosed. High throughput is achieved by firing the kiln such that optimum wall temperatures are maintained beginning at the point where the materials enter the heating section of the kiln and extending to the point where the materials leave the heated section. Multiple high velocity burners are arranged such that combustion products directly impact on the area of the kiln wall covered internally by the solid material being heated. Firing rates for the burners are controlled to maintain optimum wall temperatures.

  6. Development of a Chemoenzymatic-like and Photoswitchable Method for the High-Throughput creation of Protein Microarrays. Application to the Analysis of the Protein/Protein Interactions Involved in the YOP Virulon from Yersinia pestis.

    SciTech Connect (OSTI)

    Camarero, J A

    2006-12-07

    Protein arrays are ideal tools for the rapid analysis of whole proteomes as well as for the development of reliable and cheap biosensors. The objective of this proposal is to develop a new ligand assisted ligation method based in the naturally occurring protein trans-splicing process. This method has been used for the generation of spatially addressable arrays of multiple protein components by standard micro-lithographic techniques. Key to our approach is the use of the protein trans-splicing process. This naturally occurring process allows the development of a truly generic and highly efficient method for the covalent attachment of proteins through its C-terminus to any solid support. This technology has been used for the creation of protein chips containing several virulence factors from the human pathogen Y. pestis.

  7. Integration of High-Temperature Gas-Cooled Reactors into Industrial Process Applications

    SciTech Connect (OSTI)

    Lee Nelson

    2009-10-01

    This report is a preliminary comparison of conventional and potential HTGR-integrated processesa in several common industrial areas: ? Producing electricity via a traditional power cycle ? Producing hydrogen ? Producing ammonia and ammonia-derived products, such as fertilizer ? Producing gasoline and diesel from natural gas or coal ? Producing substitute natural gas from coal, and ? Steam-assisted gravity drainage (extracting oil from tar sands).

  8. Fabrication of crystalline Bragg reflectors for high power and integrated optical applications by

    E-Print Network [OSTI]

    Sóbester, András

    conditions, as well as having the additional benefit of use in hybrid laser crystals (e.g. integrated mirrors of fabrication and to allow mixed layer growth for grating strength apodisation. Substrates were heated via CO2 including chamber pumping and venting; this technique is hence of particular interest for rapid prototyping

  9. High Speed CMOS Output Stage for Integrated DC-DC Converters Wai Tung Ng*, Marian Changl

    E-Print Network [OSTI]

    Ng, Wai Tung

    to attain maximum channel width per unit area for low on-resistance. A typical MF layout and its equivalent DC/DC converters is characterized by power conversion efficiency, transient response, size and cost is introduced to enhance the switching speed and power conversion efficiency of low voltage integrated DC

  10. Design, Implementation and Performance of Exponential Integrators for High Performance Computing Applications

    E-Print Network [OSTI]

    Loffeld, John

    2013-01-01

    mathematics, high performance computing and computer science. Research interests: Scientific Computing, Numerical

  11. High-performance carbon-nanotube-based complementary field-effect-transistors and integrated circuits with yttrium oxide

    SciTech Connect (OSTI)

    Liang, Shibo; Zhang, Zhiyong, E-mail: zyzhang@pku.edu.cn; Si, Jia; Zhong, Donglai; Peng, Lian-Mao, E-mail: lmpeng@pku.edu.cn [Key Laboratory for the Physics and Chemistry of Nanodevices, Department of Electronics, Peking University, Beijing 100871 (China)

    2014-08-11

    High-performance p-type carbon nanotube (CNT) transistors utilizing yttrium oxide as gate dielectric are presented by optimizing oxidization and annealing processes. Complementary metal-oxide-semiconductor (CMOS) field-effect-transistors (FETs) are then fabricated on CNTs, and the p- and n-type devices exhibit symmetrical high performances, especially with low threshold voltage near to zero. The corresponding CMOS CNT inverter is demonstrated to operate at an ultra-low supply voltage down to 0.2?V, while displaying sufficient voltage gain, high noise margin, and low power consumption. Yttrium oxide is proven to be a competitive gate dielectric for constructing high-performance CNT CMOS FETs and integrated circuits.

  12. Integrating High Penetrations of Solar in the Western United States: Results of the Western Wind and Solar Integration Study Phase 2 (Poster)

    SciTech Connect (OSTI)

    Bird, L.; Lew, D.

    2013-10-01

    This poster presents a summary of the results of the Western Wind and Solar Integration Study Phase 2.

  13. Development of a High Latent Effectiveness Energy Recovery Ventilator with Integration into Rooftop Package Equipment

    SciTech Connect (OSTI)

    Gregory M. Dobbs; Norberto O. Lemcoff; Frederick J. Cogswell; Jeffrey T. Benolt

    2006-03-01

    This Final Report covers the Cooperative Program carried out to design and optimize an enhanced flat-plate energy recovery ventilator and integrate it into a packaged unitary (rooftop) air conditioning unit. The project objective was to optimize the design of a flat plate energy recovery ventilator (ERV) core that compares favorably to flat plate air-to-air heat exchanger cores on the market and to cost wise to small enthalpy wheel devices. The benefits of an integrated unit incorporating an enhanced ERV core and a downsized heating/cooling unit were characterized and the design of an integrated unit considering performance and cost was optimized. Phase I was to develop and optimize the design of a membrane based heat exchanger core. Phase II was the creation and observation of a system integrated demonstrator unit consisting of the Enhanced Energy Recovery Ventilator (EERV) developed in Phase I coupled to a standard Carrier 50HJ rooftop packaged unitary air conditioning unit. Phase III was the optimization of the system prior to commercialization based on the knowledge gained in Phase II. To assure that the designs chosen have the possibility of meeting cost objectives, a preliminary manufacturability and production cost study was performed by the Center for Automation Technologies at RPI. Phase I also included a preliminary design for the integrated unit to be further developed in Phase II. This was to assure that the physical design of the heat exchanger designed in Phase I would be acceptable for use in Phase II. An extensive modeling program was performed by the Center for Building Performance & Diagnostics of CMU. Using EnergyPlus as the software, a typical office building with multiple system configurations in multiple climatic zones in the US was simulated. The performance of energy recovery technologies in packaged rooftop HVAC equipment was evaluated. The experimental program carried out in Phases II and III consisted of fabricating and testing a demonstrator unit using Carrier Comfort Network (CCN) based controls. Augmenting the control signals, CCN was also used to monitor and record additional performance data that supported modeling and conceptual understanding. The result of the testing showed that the EERV core developed in Phase I recovered energy in the demonstrator unit at the expected levels based on projections. In fact, at near-ARI conditions the core recovered about one ton of cooling enthalpy when operating with a three-ton rooftop packaged unit.

  14. The role of SEA in integrating and balancing high policy objectives in European cohesion funding programmes

    SciTech Connect (OSTI)

    Jiricka, Alexandra Proebstl, Ulrike

    2013-01-15

    Funding programmes for European cohesion policy are a crucial tool to support the sustainability goals of the European Union and national policies of its member states. All these funding programmes require a Strategic Environmental Assessment (SEA) to enhance sustainable development. This article compares five first SEA applications at cohesion policy level to discuss challenges, limitations and benefits of this instrument. In order to support the SEA-process a 'Handbook on SEA for Cohesion Policy 2007-13' (GRDP 2006) was developed. The paper examines the special requirements and challenges at the programme level given the special conditions for stakeholder involvement, integration of SEA in the programme development process and strategies to cope with uncertainties to ensure real compatibility with policy goals. Using action research and in-depth interviews with SEA planners and programme managers enabled us to analyse the suitability of the methodology proposed by the handbook. The results show that some recommendations of the handbook should be changed in order to increase the transparency and to enhance the standard and comparability of the SEA-documents. Overall the SEA proved to be a rather successful tool for the integration of sustainability goals at the EU and national policy levels. Its particular strengths emerged as the process makes uncertainties visible and leads to possible redefinitions while maintaining actual policy goals. - Highlights: Black-Right-Pointing-Pointer Comparing five case studies of first applications of SEA at cohesion policy level. Black-Right-Pointing-Pointer Overall the SEA proved to be a rather successful tool for the integration of sustainability goals. Black-Right-Pointing-Pointer The study makes uncertainties visible and shows how SEA could lead to possible redefinitions.

  15. Algorithms for Next-Generation High-Throughput Sequencing Technologies

    E-Print Network [OSTI]

    Kao, Wei-Chun

    2011-01-01

    in the Human Genome Project(HGP) 1 . However, because Sangerprohibitive. In the case of HGP, it took more than 13 years

  16. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    x rays from one of the superconducting bend magnets at the ALS to liquid-handling robotics has enabled the collection of 96 samples in 4 hours. Importantly, the sample format...

  17. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01

    Ph. D. in Electrical Engineering (Communication Theory andin Electrical Engineering (Communication Theory and Systems)in Electrical Engineering (Communication Theory and Systems)

  18. Constant pressure high throughput membrane permeation testing system

    DOE Patents [OSTI]

    Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.

    2014-09-02

    The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.

  19. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01

    Stranded DNA Analysis. Analytical Chemistry, 2007. 79(22):Electrophoresis Chips. Analytical Chemistry, 1995. 67(20):Acid Analysis. Analytical Chemistry, 1999. 71(23): p. 5354-

  20. NETL Studies High Throughput Membrane Screening | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and economical method for gas separations from power plant flue gas streams. Polymer membranes and supported liquid membranes show great promise to solve problems in the...

  1. High-throughput pipetting with the programmable Pipetman Concept

    E-Print Network [OSTI]

    Cai, Long

    Concept® takes advantage of a PC-to-pipette connection to outperform traditional motorized pipettes include aspiration, dispensing, dilution, mixing, repetitive dispensing and many more. A few minutes

  2. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01

    and large-area graphene plane as a floor. Preparation ofgraphene was dried and prepared for dye coating. Dye Preparation and

  3. High mass throughput particle generation using multiple nozzle spraying

    DOE Patents [OSTI]

    Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Creve Coeur, MO)

    2009-03-03

    Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

  4. Differential analysis of high-throughput quantitative genetic interaction data

    E-Print Network [OSTI]

    Bean, Gordon J; Ideker, Trey

    2012-01-01

    DNA damage response (DDR)). Other biological networks, suchespecially in context of the DDR. Thus, differentialThese gene pairs indicate DDR- relevant interactions that

  5. High throughput analysis of samples in flowing liquid

    DOE Patents [OSTI]

    Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)

    2001-01-01

    Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.

  6. BLINK: A High Throughput Link Layer for Backscatter Communication

    E-Print Network [OSTI]

    Ganesan, Deepak

    in areas where small form-factor is critical (e.g. on-body sen- sors for gesture and activity recognition to active radios in urban sensing deployments -- com- munication is powered by a reader, thereby making sev- eral optimizations including 1) understanding of multi-path self-interference characteristics

  7. High-Throughput Transfer Imprinting for Organic Semiconductors 

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06

    .......................................................... 9 Figure 5 Major steps of UV nanoimprint process ................................................... 11 Figure 6 Two methods of roller nanoimprint lithography ....................................... 13 Figure 7 Steps of LADI process... of the photolithography process are illustrated in Figure1. The first step is coating UV sensitive photoresist on the substrate. A spin-coating method is widely used for the step. After coating, a short bake at about 90C is applied to remove solution from the resist...

  8. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01

    peptide-level factual FDR and PSM-level FDR 100 Table 4.11:affects the results . . . 4.4.8 PSM-level vs Peptide-level2 A peptide-spectrum match (PSM) is a pair (P, S) formed by

  9. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01

    S. , and Marra, M. Resuspension of DNA Sequencing Reactionstability. (A) Sample resuspension in low-concentrationand used as the sole resuspension buffer following sample

  10. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01

    5096–5108. 36. Macnab RM: How bacteria assemble. Annu Revgene fitness among related bacteria. BMC Genomics 2012 13:gene fitness among related bacteria Rocio Canals 1 , Xiao-

  11. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01

    adjusted as an in-line graphene measurement technique.fabrication and metrology of graphene materials. Our mainof Large-Area Hybrid Graphene-CNT Architectures 2.1

  12. MATHEMATICAL CHALLENGES IN HIGH-THROUGHPUT MICROCALORIMETER SPECTROSCOPY

    E-Print Network [OSTI]

    -Xavier Proulx, Universit´e de Montr´eal Yun Wei, University of Michigan Heng Zhu, University of Calgary Jielin sensor systems (Figure 1) have been developed at NIST, NASA, and else- where to measure the energy. These microcalorimeters have demonstrated relative energy resolution, depend- ing on the energy band, of better than 3

  13. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists have developed a fast and efficient way to determine the structure of proteins, shortening a process that often takes years into a matter of days. The Structurally...

  14. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, S.

    1994-07-12

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  15. Algorithms for Next-Generation High-Throughput Sequencing Technologies

    E-Print Network [OSTI]

    Kao, Wei-Chun

    2011-01-01

    Algorithm . . . . . . . . . . . . . . . . . . . . . .2.6.1 A hybrid base-calling algorithm . . . . . . . . .Algorithm . . . . . . . . . . . . . . . . . . . . . . . . . .

  16. Towards Experimental Annotation of Genes by High Throughput Sequencing

    SciTech Connect (OSTI)

    Bradbury, Andrew

    2010-06-03

    Andrew Bradbury of Los Alamos National Laboratory discusses turning annotation into a sequencing pipeline on June 3, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  17. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01

    exfoliated graphene oxide layers along with CVD grown CNTsto create a barrier oxide layer on copper foil. Fe catalystcopper oxide foil, the oxide layer would be gradually flow,

  18. High mass throughput particle generation using multiple nozzle spraying

    DOE Patents [OSTI]

    Pui, David Y. H.; Chen, Da-Ren

    2015-06-09

    Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

  19. High-throughput methods for characterizing the immune repertoire

    E-Print Network [OSTI]

    Laserson, Uri

    2013-01-01

    The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...

  20. Computational tools for high-throughput discovery in biology

    E-Print Network [OSTI]

    Jones, Neil Christopher

    2007-01-01

    implementing “better” Grid security within a VO occurs whenPearlman, and S. Tuecke. Security for grid services. In 12thGrid), which is a sort of metaservice collection that handles indexing, discovery, security,

  1. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01

    graphene industrially, in areas such as energy, semiconductorgraphene to n- and p-type, which are required for complementary metal oxide semiconductor (

  2. Microfluidic Technologies for High-Throughput Screening Applications

    E-Print Network [OSTI]

    Quake, Stephen R.

    -based dynamic formation of picoliter-sized water droplets in a continuously flowing oil-surfactant stream for all of his valuable combinatorial chemistry advice and the generous use of lab space and supplies and electronics. Second, I would like to thank a large number of professors outside of my field that directly

  3. Computational tools for high-throughput discovery in biology

    E-Print Network [OSTI]

    Jones, Neil Christopher

    2007-01-01

    Towards creating a compute power grid. Cluster Computing andfor all data processing: the power grid. With a well-frameddevelopers. Since this Power Grid analogy has more or less

  4. METHODS AND APPLICATIONS High-throughput instant quantification of

    E-Print Network [OSTI]

    Ihee, Hyotcherl

    based on photoactive yellow protein turn off/on label Youngmin Kim,1,2 Prabhakar Ganesan,1 on the Photoactive yellow protein turn Off/On Label (POOL) system that can instantly quan- tify the concentration Gel Electrophoresis; POOL, PYP turn Off/On Label; PYP, Photoactive Yellow Protein; SUMO, Small

  5. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  6. An apparatus for high throughput muscle cell experimentation

    E-Print Network [OSTI]

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  7. Advanced method for high-throughput expression of mutated eukaryotic...

    Office of Scientific and Technical Information (OSTI)

    ; Murata, Takeshi 2 ; Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Konoe-cho, Yoshida, Sakyo-Ku, Kyoto 606-8501 4 ; Abe, Keiko 1 ; Iwata, So 2 ;...

  8. High-Throughput Single-Cell Manipulation in Brain Tissue

    E-Print Network [OSTI]

    Steinmeyer, Joseph Daly

    The complexity of neurons and neuronal circuits in brain tissue requires the genetic manipulation, labeling, and tracking of single cells. However, current methods for manipulating cells in brain tissue are limited to ...

  9. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01

    30 V/cm), followed by direct injection of analyte from thethen tested, although direct injection of 4 µL (12 x 10 6is observed following direct injection from waste to anode (

  10. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01

    the automation of the technique for production-linethe automation of the technique for production-line

  11. High-throughput Microfluidic Screening Platforms for Microalgae Study 

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15

    Microalgae have been envisioned as a future source of renewable energy. Both fossil fuel depletion and environmental concern have drawn more interest in microalgal biofuels, but the production cost of these biofuels are not yet economically...

  12. Potential of High-Throughput Experimentation with Ammonia Borane Solid

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1,anEnergyDepartment ofPotential Health-Hydrogen

  13. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration

  14. High-Throughput Characterization of Porous Materials Using Graphics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you notHeat Pumps Heat Pumps An error occurred.

  15. Constant pressure high throughput membrane permeation testing system

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing BacteriaConnect Collider Tests ofO y''Softening-Bipolaron''Article) |(Patent) |

  16. Constant pressure high throughput membrane permeation testing system

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing BacteriaConnect Collider Tests ofO y''Softening-Bipolaron''Article) |(Patent)

  17. Advanced method for high-throughput expression of mutated eukaryotic

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnicalInformation4563Abuse Tolerance(Conference) |stabilizedmembrane proteins in

  18. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) byMultidayAlumni > The Energy Materials CenterRobotics Key to

  19. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) byMultidayAlumni > The Energy Materials CenterRobotics Key toRobust,

  20. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01

    Second, a solar cell's efficiency increases underproduce large-area, high-efficiency solar cells than it issystems [58]. Solar cell efficiencies can be dramatically

  1. Throughput-cost analysis of optical flow switching

    E-Print Network [OSTI]

    Chan, Vincent W. S.

    In this paper, we employ a cost model embodying major sources of capital expenditure (CapEx) to compare the throughput-cost tradeoff offered by optical flow switching to that of more traditional optical network architectures.

  2. Outage-based throughput in wireless packet networks

    E-Print Network [OSTI]

    Win, Moe Z.

    With the increased competition for the electromagnetic spectrum, it is important to characterize the impact of interference in the performance of a wireless packet network, which is traditionally measured by its throughput. ...

  3. A Journal of Integrative Biology Spider Silk Aging: Initial Improvement in a High

    E-Print Network [OSTI]

    Agnarsson, Ingi

    in the mechanical properties of dragline and capture silk fibers from several spider species over periods up to 4 of orb webs and are the main focus of biomimetic research (Fig. 1). Spiders use dragline silk, spun from from high places. Dragline silk can match steel in strength but is also highly elastic and thus

  4. Integrated Results for Dual Low Voltage IC Based High and Low Side Gate Drive

    E-Print Network [OSTI]

    , electronicballast I. INTRODUCTION High and low side gate drivers are required in most switching power converters Zane Colorado Power Electronics Center (CoPEC) Department of Electrical and Computer Engineering, UCB design for high and low side gate drive is presented based on use of two identical low voltage ICs

  5. High-Temperature SiC Power Module with Integrated SiC Gate Drivers for Future High-Density Power Electronics Applications

    SciTech Connect (OSTI)

    Whitaker, Mr. Bret [APEI, Inc.; Cole, Mr. Zach [APEI, Inc.; Passmore, Mr. Brandon [APEI, Inc.; Martin, Daniel [APEI, Inc.; Mcnutt, Tyler [APEI, Inc.; Lostetter, Dr. Alex [APEI, Inc.; Ericson, Milton Nance [ORNL; Frank, Steven Shane [ORNL; Britton Jr, Charles L [ORNL; Marlino, Laura D [ORNL; Mantooth, Alan [University of Arkansas; Francis, Dr. Matt [University of Arkansas; Lamichhane, Ranjan [University of Arkansas; Shepherd, Dr. Paul [University of Arkansas; Glover, Dr. Michael [University of Arkansas

    2015-01-01

    This paper presents the testing results of an all-silicon carbide (SiC) intelligent power module (IPM) for use in future high-density power electronics applications. The IPM has high-temperature capability and contains both SiC power devices and SiC gate driver integrated circuits (ICs). The high-temperature capability of the SiC gate driver ICs allows for them to be packaged into the power module and be located physically close to the power devices. This provides a distinct advantage by reducing the gate driver loop inductance, which promotes high frequency operation, while also reducing the overall volume of the system through higher levels of integration. The power module was tested in a bridgeless-boost converter to showcase the performance of the module in a system level application. The converter was initially operated with a switching frequency of 200 kHz with a peak output power of approximately 5 kW. The efficiency of the converter was then evaluated experimentally and optimized by increasing the overdrive voltage on the SiC gate driver ICs. Overall a peak efficiency of 97.7% was measured at 3.0 kW output. The converter s switching frequency was then increased to 500 kHz to prove the high frequency capability of the power module was then pushed to its limits and operated at a switching frequency of 500 kHz. With no further optimization of components, the converter was able to operate under these conditions and showed a peak efficiency of 95.0% at an output power of 2.1 kW.

  6. Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

    SciTech Connect (OSTI)

    Chakravarty, Swapnajit, E-mail: swapnajit.chakravarty@omegaoptics.com; Hosseini, Amir; Xu, Xiaochuan [Omega Optics, Inc., Austin, Texas 78757 (United States); Zhu, Liang; Zou, Yi [Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758 (United States); Chen, Ray T., E-mail: raychen@uts.cc.utexas.edu [Omega Optics, Inc., Austin, Texas 78757 (United States); Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, Texas 78758 (United States)

    2014-05-12

    We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1?×?10{sup ?7} RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date.

  7. Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs

    E-Print Network [OSTI]

    van der Mei, Rob

    Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs Sandjai@feweb.vu.nl Abstract-- The wireless LAN technology 802.11, also called Wi-Fi, offers high speed wireless Internet by simulation results. I. INTRODUCTION The wireless LAN (WLAN) industry is one of the fastest growing segments

  8. Highly polarized light emission by isotropic quantum dots integrated with magnetically aligned segmented nanowires

    SciTech Connect (OSTI)

    Uran, Can; Erdem, Talha; Guzelturk, Burak; Perkgöz, Nihan Kosku; Jun, Shinae; Jang, Eunjoo; Demir, Hilmi Volkan

    2014-10-06

    In this work, we demonstrate a proof-of-concept system for generating highly polarized light from colloidal quantum dots (QDs) coupled with magnetically aligned segmented Au/Ni/Au nanowires (NWs). Optical characterizations reveal that the optimized QD-NW coupled structures emit highly polarized light with an s-to p-polarization (s/p) contrast as high as 15:1 corresponding to a degree of polarization of 0.88. These experimental results are supported by the finite-difference time-domain simulations, which demonstrate the interplay between the inter-NW distance and the degree of polarization.

  9. Method for critical software event execution reliability in high integrity software

    SciTech Connect (OSTI)

    Kidd, M.E. [Sandia National Labs., Albuquerque, NM (United States)

    1997-11-01

    This report contains viewgraphs on a method called SEER, which provides a high level of confidence that critical software driven event execution sequences faithfully exceute in the face of transient computer architecture failures in both normal and abnormal operating environments.

  10. An integrated performance model for high temperature gas cooled reactor coated particle fuel

    E-Print Network [OSTI]

    Wang, Jing, 1976-

    2004-01-01

    The performance of coated fuel particles is essential for the development and deployment of High Temperature Gas Reactor (HTGR) systems for future power generation. Fuel performance modeling is indispensable for understanding ...

  11. A simple way to the high-temperature expansion of relativistic Fermi-Dirac integrals

    E-Print Network [OSTI]

    Khvorostukhin, A S

    2015-01-01

    The pressure of an ideal relativistic Fermi gas is computed as an infinite series for high temperatures. Expansion of the particle number density, the scalar density, and the entropy density as first derivatives of the pressure is also found.

  12. Approaches To Integrating A HIgh Penertration Of Solar PV and CPV Onto The Electrical Grid

    E-Print Network [OSTI]

    Hill, Steven Craig

    2013-01-01

    for peaking or base load generation and PV cost. The paper1) the break-even cost of PV is unacceptably high unless PVlarge scale PV inverters due to the cost of energy storage

  13. Millimeter-wave GaN high electron mobility transistors and their integration with silicon electronics

    E-Print Network [OSTI]

    Chung, Jinwook W. (Jinwook Will)

    2011-01-01

    In spite of the great progress in performance achieved during the last few years, GaN high electron mobility transistors (HEMTs) still have several important issues to be solved for millimeter-wave (30 ~ 300 GHz) applications. ...

  14. High-precision transfer-printing and integration of vertically oriented semiconductor arrays for flexible

    E-Print Network [OSTI]

    Yoo, S. J. Ben

    transfer printing, nanowires, flexible electronics, printable electronics, nanoscale devices ABSTRACT Flexible electronics utilizing single crystalline semiconductors typically require post-growth processes devices. High performance electronics on flexible substrates have been gaining attention from research

  15. Policies and Programs to Integrate High Penetrations of Variable Renewable Energy (Presentation)

    SciTech Connect (OSTI)

    Cochran, J.

    2012-06-01

    The goals of this project are to highlight the diverse approaches for enabling high renewable energy penetration; synthesize lessons on effective policies and programs and present avenues for action to energy ministers and other stakeholders.

  16. Transmit field pattern control for high field magnetic resonance imaging with integrated RF current sources 

    E-Print Network [OSTI]

    Kurpad, Krishna Nagaraj

    2005-11-01

    The primary design criterion for RF transmit coils for MRI is uniform transverse magnetic (B1) field. Currently, most high frequency transmit coils are designed as periodic, symmetric structures that are resonant at the imaging frequency...

  17. A HighTemperature Embedded Network Interface using Software Thread Integration

    E-Print Network [OSTI]

    Dean, Alexander G.

    with jet fuel in an aircraft engine). Many applications are unable to bear the added cost, size, weight environment (200° C / 392° F). Low production volumes lead to high prices due to the lack of economies

  18. A High-Temperature Embedded Network Interface using Software Thread Integration

    E-Print Network [OSTI]

    Dean, Alexander G.

    with jet fuel in an aircraft engine). Many applications are unable to bear the added cost, size, weight environment (200° C / 392° F). Low production volumes lead to high prices due to the lack of economies

  19. Analysis of system wide distortion in an integrated power system utilizing a high voltage DC bus and silicon carbide power devices

    E-Print Network [OSTI]

    Fallier, William F. (William Frederick)

    2007-01-01

    This research investigates the distortion on the electrical distribution system for a high voltage DC Integrated Power System (IPS). The analysis was concentrated on the power supplied to a propulsion motor driven by an ...

  20. Integrating atomic layer deposition and ultra-high vacuum physical vapor deposition for in situ fabrication of tunnel junctions

    SciTech Connect (OSTI)

    Elliot, Alan J., E-mail: alane@ku.edu, E-mail: jwu@ku.edu; Malek, Gary A.; Lu, Rongtao; Han, Siyuan; Wu, Judy Z., E-mail: alane@ku.edu, E-mail: jwu@ku.edu [Department of Physics and Astronomy, The University of Kansas, Lawrence, Kansas 66045 (United States); Yu, Haifeng; Zhao, Shiping [Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

    2014-07-15

    Atomic Layer Deposition (ALD) is a promising technique for growing ultrathin, pristine dielectrics on metal substrates, which is essential to many electronic devices. Tunnel junctions are an excellent example which require a leak-free, ultrathin dielectric tunnel barrier of typical thickness around 1 nm between two metal electrodes. A challenge in the development of ultrathin dielectric tunnel barriers using ALD is controlling the nucleation of dielectrics on metals with minimal formation of native oxides at the metal surface for high-quality interfaces between the tunnel barrier and metal electrodes. This poses a critical need for integrating ALD with ultra-high vacuum (UHV) physical vapor deposition. In order to address these challenges, a viscous-flow ALD chamber was designed and interfaced to an UHV magnetron sputtering chamber via a load lock. A sample transportation system was implemented for in situ sample transfer between the ALD, load lock, and sputtering chambers. Using this integrated ALD-UHV sputtering system, superconductor-insulator-superconductor (SIS) Nb-Al/Al{sub 2}O{sub 2}/Nb Josephson tunnel junctions were fabricated with tunnel barriers of thickness varied from sub-nm to ?1 nm. The suitability of using an Al wetting layer for initiation of the ALD Al{sub 2}O{sub 3} tunnel barrier was investigated with ellipsometry, atomic force microscopy, and electrical transport measurements. With optimized processing conditions, leak-free SIS tunnel junctions were obtained, demonstrating the viability of this integrated ALD-UHV sputtering system for the fabrication of tunnel junctions and devices comprised of metal-dielectric-metal multilayers.

  1. A One System Integrated Approach to Simulant Selection for Hanford High Level Waste Mixing and Sampling Tests

    SciTech Connect (OSTI)

    Thien, Mike G. [Washington River Protection Solutions, LLC, Richland, WA (United States); Barnes, Steve M. [URS, Richland, WA (United States)

    2013-01-17

    The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capabilities using simulated Hanford High-Level Waste (HLW) formulations. This represents one of the largest remaining technical issues with the high-level waste treatment mission at Hanford. Previous testing has focused on very specific TOC or WTP test objectives and consequently the simulants were narrowly focused on those test needs. A key attribute in the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2010-2 is to ensure testing is performed with a simulant that represents the broad spectrum of Hanford waste. The One System Integrated Project Team is a new joint TOC and WTP organization intended to ensure technical integration of specific TOC and WTP systems and testing. A new approach to simulant definition has been mutually developed that will meet both TOC and WTP test objectives for the delivery and receipt of HLW. The process used to identify critical simulant characteristics, incorporate lessons learned from previous testing, and identify specific simulant targets that ensure TOC and WTP testing addresses the broad spectrum of Hanford waste characteristics that are important to mixing, sampling, and transfer performance are described.

  2. Integrated Process Configuration for High-Temperature Sulfur Mitigation during Biomass Conversion via Indirect Gasification

    SciTech Connect (OSTI)

    Dutta. A.; Cheah, S.; Bain, R.; Feik, C.; Magrini-Bair, K.; Phillips, S.

    2012-06-20

    Sulfur present in biomass often causes catalyst deactivation during downstream operations after gasification. Early removal of sulfur from the syngas stream post-gasification is possible via process rearrangements and can be beneficial for maintaining a low-sulfur environment for all downstream operations. High-temperature sulfur sorbents have superior performance and capacity under drier syngas conditions. The reconfigured process discussed in this paper is comprised of indirect biomass gasification using dry recycled gas from downstream operations, which produces a drier syngas stream and, consequently, more-efficient sulfur removal at high temperatures using regenerable sorbents. A combination of experimental results from NREL's fluidizable Ni-based reforming catalyst, fluidizable Mn-based sulfur sorbent, and process modeling information show that using a coupled process of dry gasification with high-temperature sulfur removal can improve the performance of Ni-based reforming catalysts significantly.

  3. An Integrated Study of a Novel Thermal Coating for Nb-Based High Temperature Alloy

    SciTech Connect (OSTI)

    Yang, Shizhong

    2015-01-31

    This report summarizes our recent works of ab initio density functional theory (DFT) method and molecular dynamics (MD) simulation on the interfaces between niobium substrate and coatings at atomic level. Potential oxidation barrier bond coat, Nb?AlC and high entropy alloys, and top coat candidates were synthesized, characterized, and evaluated in our labs. The simulation methods, experimental validation techniques, achievements already reached, students and postdoc training, and future improvement are briefly introduced.

  4. High-Voltage LED Light Engine with Integrated Driver | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls - Building America Topa High BindingVoltage LED

  5. Cost Effective, High Efficiency Integrated Systems Approach to Auxilliary Electric Motors

    SciTech Connect (OSTI)

    Roy Kessinger Jr.; Keith Seymour; Kanchan Angal; Jason Wolf; Steve Brewer; Leonard Schrank

    2003-09-26

    The CARAT program, carried out by Kinetic Art & Technology Corporation (KAT), has been one of the most commercially successful KAT R&D programs to date. Based on previous development of its technology, KAT designed, constructed and tested a highly efficient motor and controller system under this CARAT program with supplemental commercial funding. Throughout this CARAT effort, the technical objectives have been refined and refocused. Some objectives have been greatly expanded, while others have been minimized. The determining factor in all decisions to refocus the objectives was the commercial need, primarily the needs of KAT manufacturing partners. Several companies are employing the resulting CARAT motor and controller designs in prototypes for commercial products. Two of these companies have committed to providing cost share in order to facilitate the development. One of these companies is a major manufacturing company developing a revolutionary new family of products requiring the ultra-high system efficiency achievable by the KAT motor and controller technologies (known as Segmented ElectroMagnetic Array, or SEMA technology). Another company requires the high efficiency, quiet operation, and control characteristics afforded by the same basic motor and controller for an advanced air filtration product. The combined annual production requirement projected by these two companies exceeds one million units by 2005.

  6. High-Responsivity Graphene-Boron Nitride Photodetector and Autocorrelator in a Silicon Photonic Integrated Circuit

    E-Print Network [OSTI]

    Shiue, Ren-Jye; Wang, Yifei; Peng, Cheng; Robertson, Alexander D; Efetov, Dimitri; Assefa, Solomon; Koppens, Frank H L; Hone, James; Englund, Dirk

    2015-01-01

    Graphene and other two-dimensional (2D) materials have emerged as promising materials for broadband and ultrafast photodetection and optical modulation. These optoelectronic capabilities can augment complementary metal-oxide-semiconductor (CMOS) devices for high-speed and low-power optical interconnects. Here, we demonstrate an on-chip ultrafast photodetector based on a two-dimensional heterostructure consisting of high-quality graphene encapsulated in hexagonal boron nitride. Coupled to the optical mode of a silicon waveguide, this 2D heterostructure-based photodetector exhibits a maximum responsivity of 0.36 A/W and high-speed operation with a 3 dB cut-off at 42 GHz. From photocurrent measurements as a function of the top-gate and source-drain voltages, we conclude that the photoresponse is consistent with hot electron mediated effects. At moderate peak powers above 50 mW, we observe a saturating photocurrent consistent with the mechanisms of electron-phonon supercollision cooling. This nonlinear photorespo...

  7. Maglev vehicles and superconductor technology: Integration of high-speed ground transportation into the air travel system

    SciTech Connect (OSTI)

    Johnson, L.R.; Rote, D.M.; Hull, J.R.; Coffey, H.T.; Daley, J.G.; Giese, R.F.

    1989-04-01

    This study was undertaken to (1) evaluate the potential contribution of high-temperature superconductors (HTSCs) to the technical and economic feasibility of magnetically levitated (maglev) vehicles, (2) determine the status of maglev transportation research in the United States and abroad, (3) identify the likelihood of a significant transportation market for high-speed maglev vehicles, and (4) provide a preliminary assessment of the potential energy and economic benefits of maglev systems. HTSCs should be considered as an enhancing, rather than an enabling, development for maglev transportation because they should improve reliability and reduce energy and maintenance costs. Superconducting maglev transportation technologies were developed in the United States in the late 1960s and early 1970s. Federal support was withdrawn in 1975, but major maglev transportation programs were continued in Japan and West Germany, where full-scale prototypes now carry passengers at speeds of 250 mi/h in demonstration runs. Maglev systems are generally viewed as very-high-speed train systems, but this study shows that the potential market for maglev technology as a train system, e.g., from one downtown to another, is limited. Rather, aircraft and maglev vehicles should be seen as complementing rather than competing transportation systems. If maglev systems were integrated into major hub airport operations, they could become economical in many relatively high-density US corridors. Air traffic congestion and associated noise and pollutant emissions around airports would also be reduced. 68 refs., 26 figs., 16 tabs.

  8. Generation IV Reactors Integrated Materials Technology Program Plan: Focus on Very High Temperature Reactor Materials

    SciTech Connect (OSTI)

    Corwin, William R; Burchell, Timothy D; Katoh, Yutai; McGreevy, Timothy E; Nanstad, Randy K; Ren, Weiju; Snead, Lance Lewis; Wilson, Dane F

    2008-08-01

    Since 2002, the Department of Energy's (DOE's) Generation IV Nuclear Energy Systems (Gen IV) Program has addressed the research and development (R&D) necessary to support next-generation nuclear energy systems. The six most promising systems identified for next-generation nuclear energy are described within this roadmap. Two employ a thermal neutron spectrum with coolants and temperatures that enable hydrogen or electricity production with high efficiency (the Supercritical Water Reactor-SCWR and the Very High Temperature Reactor-VHTR). Three employ a fast neutron spectrum to enable more effective management of actinides through recycling of most components in the discharged fuel (the Gas-cooled Fast Reactor-GFR, the Lead-cooled Fast Reactor-LFR, and the Sodium-cooled Fast Reactor-SFR). The Molten Salt Reactor (MSR) employs a circulating liquid fuel mixture that offers considerable flexibility for recycling actinides and may provide an alternative to accelerator-driven systems. At the inception of DOE's Gen IV program, it was decided to significantly pursue five of the six concepts identified in the Gen IV roadmap to determine which of them was most appropriate to meet the needs of future U.S. nuclear power generation. In particular, evaluation of the highly efficient thermal SCWR and VHTR reactors was initiated primarily for energy production, and evaluation of the three fast reactor concepts, SFR, LFR, and GFR, was begun to assess viability for both energy production and their potential contribution to closing the fuel cycle. Within the Gen IV Program itself, only the VHTR class of reactors was selected for continued development. Hence, this document will address the multiple activities under the Gen IV program that contribute to the development of the VHTR. A few major technologies have been recognized by DOE as necessary to enable the deployment of the next generation of advanced nuclear reactors, including the development and qualification of the structural materials needed to ensure their safe and reliable operation. The focus of this document will be the overall range of DOE's structural materials research activities being conducted to support VHTR development. By far, the largest portion of material's R&D supporting VHTR development is that being performed directly as part of the Next-Generation Nuclear Plant (NGNP) Project. Supplementary VHTR materials R&D being performed in the DOE program, including university and international research programs and that being performed under direct contracts with the American Society for Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, will also be described. Specific areas of high-priority materials research that will be needed to deploy the NGNP and provide a basis for subsequent VHTRs are described, including the following: (1) Graphite: (a) Extensive unirradiated materials characterization and assessment of irradiation effects on properties must be performed to qualify new grades of graphite for nuclear service, including thermo-physical and mechanical properties and their changes, statistical variations from billot-to-billot and lot-to-lot, creep, and especially, irradiation creep. (b) Predictive models, as well as codification of the requirements and design methods for graphite core supports, must be developed to provide a basis for licensing. (2) Ceramics: Both fibrous and load-bearing ceramics must be qualified for environmental and radiation service as insulating materials. (3) Ceramic Composites: Carbon-carbon and SiC-SiC composites must be qualified for specialized usage in selected high-temperature components, such as core stabilizers, control rods, and insulating covers and ducting. This will require development of component-specific designs and fabrication processes, materials characterization, assessment of environmental and irradiation effects, and establishment of codes and standards for materials testing and design requirements. (4) Pressure Vessel Steels: (a) Qualification of short-term, high-temperature properties of light water rea

  9. THE INTEGRATION OF PROCESS HEAT APPLICATIONS TO HIGH TEMPERATURE GAS REACTORS

    SciTech Connect (OSTI)

    Michael G. McKellar

    2011-11-01

    A high temperature gas reactor, HTGR, can produce industrial process steam, high-temperature heat-transfer gases, and/or electricity. In conventional industrial processes, these products are generated by the combustion of fossil fuels such as coal and natural gas, resulting in significant emissions of greenhouse gases such as carbon dioxide. Heat or electricity produced in an HTGR could be used to supply process heat or electricity to conventional processes without generating any greenhouse gases. Process heat from a reactor needs to be transported by a gas to the industrial process. Two such gases were considered in this study: helium and steam. For this analysis, it was assumed that steam was delivered at 17 MPa and 540 C and helium was delivered at 7 MPa and at a variety of temperatures. The temperature of the gas returning from the industrial process and going to the HTGR must be within certain temperature ranges to maintain the correct reactor inlet temperature for a particular reactor outlet temperature. The returning gas may be below the reactor inlet temperature, ROT, but not above. The optimal return temperature produces the maximum process heat gas flow rate. For steam, the delivered pressure sets an optimal reactor outlet temperature based on the condensation temperature of the steam. ROTs greater than 769.7 C produce no additional advantage for the production of steam.

  10. NREL/SCE High Penetration PV Integration Project: FY13 Annual Report

    SciTech Connect (OSTI)

    Mather, B. A.; Shah, S.; Norris, B. L.; Dise, J. H.; Yu, L.; Paradis, D.; Katiraei, F.; Seguin, R.; Costyk, D.; Woyak, J.; Jung, J.; Russell, K.; Broadwater, R.

    2014-06-01

    In 2010, the National Renewable Energy Laboratory (NREL), Southern California Edison (SCE), Quanta Technology, Satcon Technology Corporation, Electrical Distribution Design (EDD), and Clean Power Research (CPR) teamed to analyze the impacts of high penetration levels of photovoltaic (PV) systems interconnected onto the SCE distribution system. This project was designed specifically to benefit from the experience that SCE and the project team would gain during the installation of 500 megawatts (MW) of utility-scale PV systems (with 1-5 MW typical ratings) starting in 2010 and completing in 2015 within SCE's service territory through a program approved by the California Public Utility Commission (CPUC). This report provides the findings of the research completed under the project to date.

  11. Integration of High Temperature Gas-cooled Reactor Technology with Oil Sands Processes

    SciTech Connect (OSTI)

    L.E. Demick

    2011-10-01

    This paper summarizes an evaluation of siting an HTGR plant in a remote area supplying steam, electricity and high temperature gas for recovery and upgrading of unconventional crude oil from oil sands. The area selected for this evaluation is the Alberta Canada oil sands. This is a very fertile and active area for bitumen recovery and upgrading with significant quantities piped to refineries in Canada and the U.S Additionally data on the energy consumption and other factors that are required to complete the evaluation of HTGR application is readily available in the public domain. There is also interest by the Alberta oil sands producers (OSP) in identifying alternative energy sources for their operations. It should be noted, however, that the results of this evaluation could be applied to any similar oil sands area.

  12. VESPA: Software to Facilitate Genomic Annotation of Prokaryotic Organisms Through Integration of Proteomic and Transcriptomic Data

    SciTech Connect (OSTI)

    Peterson, Elena S.; McCue, Lee Ann; Rutledge, Alexandra C.; Jensen, Jeffrey L.; Walker, Julia; Kobold, Mark A.; Webb, Samantha R.; Payne, Samuel H.; Ansong, Charles; Adkins, Joshua N.; Cannon, William R.; Webb-Robertson, Bobbie-Jo M.

    2012-04-25

    Visual Exploration and Statistics to Promote Annotation (VESPA) is an interactive visual analysis software tool that facilitates the discovery of structural mis-annotations in prokaryotic genomes. VESPA integrates high-throughput peptide-centric proteomics data and oligo-centric or RNA-Seq transcriptomics data into a genomic context. The data may be interrogated via visual analysis across multiple levels of genomic resolution, linked searches, exports and interaction with BLAST to rapidly identify location of interest within the genome and evaluate potential mis-annotations.

  13. Disposal demonstration of a high integrity container (HIC) containing an EPICOR-II prefilter from Three Mile Island

    SciTech Connect (OSTI)

    McConnell, J.W. Jr.; Tyacke, M.J.; Schmitt, R.C.; Reno, H.W.

    1985-02-01

    A high integrity container (HIC) was developed, tested, and certified for use in disposing of unusual low-level radioactive waste from Three Mile Island Unit 2 (TMI-2). The work was coordinated by EG and G Idaho, Inc. and funded by the US Department of Energy. A disposal demonstration using an HIC containing an EPICOR-II prefilter from TMI-2 was completed at the commercial disposal facility in the State of Washington. A Certification of Compliance was issued by the Department of Social and Health Services of the State of Washington to use the HIC in disposing of up to 50 EPICOR-II prefilters. That Certification of Compliance was issued after rigorous review of the HIC design and test program by the State and by the US Nuclear Regulatory Commission. This report describes the processes of loading, transporting, and disposing of the demonstration HIC and briefly describes the design, testing, and approval effort leading up to the demonstration.

  14. High-performance broadband optical coatings on InGaN/GaN solar cells for multijunction device integration

    SciTech Connect (OSTI)

    Young, N. G. Farrell, R. M.; Iza, M.; Speck, J. S.; Perl, E. E.; Keller, S.; Bowers, J. E.; Nakamura, S.; DenBaars, S. P.

    2014-04-21

    We demonstrate InGaN/GaN multiple quantum well solar cells grown by metalorganic chemical vapor deposition on a bulk (0001) substrate with high-performance broadband optical coatings to improve light absorption. A front-side anti-reflective coating and a back-side dichroic mirror were designed to minimize front surface reflections across a broad spectral range and maximize rear surface reflections only in the spectral range absorbed by the InGaN, making the cells suitable for multijunction solar cell integration. Application of optical coatings increased the peak external quantum efficiency by 56% (relative) and conversion efficiency by 37.5% (relative) under 1 sun AM0 equivalent illumination.

  15. Application-Specific Economic Analysis of Integral Passives in Printed Circuit Boards

    E-Print Network [OSTI]

    Sandborn, Peter

    Application-Specific Economic Analysis of Integral Passives in Printed Circuit Boards Bevin Etienne to integral passives that are embedded within a printed circuit board. In this study we assume that integral of ownership model is used to determine the impact of throughput changes associated with fabricating integral

  16. Models for the Configuration and Integrity of Partially Oxidized Fuel Rod Cladding at High Temperatures - Final Design Report

    SciTech Connect (OSTI)

    Siefken, Larry James

    1999-02-01

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. The modeling was improved in five areas. First, the configuration defined for melted metallic cladding retained by an adjacent oxide layer was improved. Second, the empirical model to account for the effect on oxidation of intact cladding is not significantly reduced by the presence of a rather high concentration of relocated material. Third, models for the dissolution of the oxide layer by the metallic layer were implemented into the code. Fourth, a model was added to calculate the thermal stress applied to the oxide layer by the temperature gradient across the oxide layer and to compare this stress to the ultimate strength of the oxide layer. Fifth, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The assessment of these models and their integration into SCDAP/RELAP5 showed that the calculated axial distribution in cladding oxidation and relocation are in significantly better agreement with experimental results than is currently the case. The modeling changes account for three aspects of behavior that were not previously calculated correctly. The implementation of these models eliminates to a significant extent the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material.

  17. Models for the configuration and integrity of partially oxidized fuel rod cladding at high temperatures -- Final Design Report

    SciTech Connect (OSTI)

    Siefken, L.J.

    1999-01-01

    Models were designed to resolve deficiencies in the SCDAP/RELAP5/MOD3.2 calculations of the configuration and integrity of hot, partially oxidized cladding. The modeling was improved in five areas. First, the configuration defined for melted metallic cladding retained by an adjacent oxide layer was improved. Second, the empirical model to account for the effect on oxidation of intact cladding is not significantly reduced by the presence of a rather high concentration of relocated material. Third, models for the dissolution of the oxide layer by the metallic layer were implemented into the code. Fourth, a model was added to calculate the thermal stress applied to the oxide layer by the temperature gradient across the oxide layer and to compare this stress to the ultimate strength of the oxide layer. Fifth, a new rule based on theoretical and experimental results was established for identifying the regions of a fuel rod with oxidation of both the inside and outside surfaces of the cladding. The assessment of these models and their integration into SCDAP/RELAP5 showed that the calculated axial distribution in cladding oxidation and relocation are in significantly better agreement with experimental results than is currently the case. The modeling changes account for three aspects of behavior that were not previously calculated correctly. The implementation of these models eliminates to a significant extent the tendency of the SCDAP/RELAP5 code to overpredict the extent of oxidation of the upper part of fuel rods and to underpredict the extent of oxidation of the lower part of fuel rods and the part with a high concentration of relocated material.

  18. Producing thin film photovoltaic modules with high integrity interconnects and dual layer contacts

    DOE Patents [OSTI]

    Jansen, Kai W. (Lawrenceville, NJ); Maley, Nagi (Exton, PA)

    2001-01-01

    High performance photovoltaic modules are produced with improved interconnects by a special process. Advantageously, the photovoltaic modules have a dual layer back (rear) contact and a front contact with at least one layer. The front contact and the inner layer of the back contact can comprise a transparent conductive oxide. The outer layer of the back contact can comprise a metal or metal oxide. The front contact can also have a dielectric layer. In one form, the dual layer back contact comprises a zinc oxide inner layer and an aluminum outer layer and the front contact comprises a tin oxide inner layer and a silicon dioxide dielectric outer layer. One or more amorphous silicon-containing thin film semiconductors can be deposited between the front and back contacts. The contacts can be positioned between a substrate and an optional superstrate. During production, the transparent conductive oxide layer of the front contact is scribed by a laser, then the amorphous silicon-containing semiconductors and inner layer of the dual layer back contact are simultaneously scribed and trenched (drilled) by the laser and the trench is subsequently filled with the same metal as the outer layer of the dual layer back contact to provide a superb mechanical and electrical interconnect between the front contact and the outer layer of the dual layer back contact. The outer layer of the dual layer back contact can then be scribed by the laser. For enhanced environmental protection, the photovoltaic modules can be encapsulated.

  19. Producing thin film photovoltaic modules with high integrity interconnects and dual layer contacts

    DOE Patents [OSTI]

    Jansen, Kai W. (Lawrenceville, NJ); Maley, Nagi (Exton, PA)

    2000-01-01

    High performance photovoltaic modules are produced with improved interconnects by a special process. Advantageously, the photovoltaic modules have a dual layer back (rear) contact and a front contact with at least one layer. The front contact and the inner layer of the back contact can comprise a transparent conductive oxide. The outer layer of the back contact can comprise a metal or metal oxide. The front contact can also have a dielectric layer. In one form, the dual layer back contact comprises a zinc oxide inner layer and an aluminum outer layer and the front contact comprises a tin oxide inner layer and a silicon dioxide dielectric outer layer. One or more amorphous silicon-containing thin film semiconductors can be deposited between the front and back contacts. The contacts can be positioned between a substrate and an optional superstrate. During production, the transparent conductive oxide layer of the front contact is scribed by a laser, then the amorphous silicon-containing semiconductors and inner layer of the dual layer back contact are simultaneously scribed and trenched (drilled) by the laser and the trench is subsequently filled with the same metal as the outer layer of the dual layer back contact to provide a superb mechanical and electrical interconnect between the front contact and the outer layer of the dual layer back contact. The outer layer of the dual layer back contact can then be scribed by the laser. For enhanced environmental protection, the photovoltaic modules can be encapsulated.

  20. New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Guss, Adam M.; Rother, Michael; Zhang, Jun Kai; Kulkkarni, Gargi; Metcalf, William W.

    2008-01-01

    A highly efficient method for chromosomal integration of cloned DNA into Methanosarcina spp. was developed utilizing the site-specific recombination system from the Streptomyces phage ?C31. Host strains expressing the ?C31 integrase gene and carrying an appropriate recombination site can be transformed with non-replicating plasmids carrying the complementary recombination site at efficiencies similar to those obtained with self-replicating vectors. We have also constructed a series of hybrid promoters that combine the highly expressed M. barkeri P mcrB promoter with binding sites for the tetracycline-responsive, bacterial TetR protein. These promoters are tightly regulated by the presence or absence of tetracycline inmore »strains that express the tetR gene. The hybrid promoters can be used in genetic experiments to test gene essentiality by placing a gene of interest under their control. Thus, growth of strains with tetR -regulated essential genes becomes tetracycline-dependent. A series of plasmid vectors that utilize the site-specific recombination system for construction of reporter gene fusions and for tetracycline regulated expression of cloned genes are reported. These vectors were used to test the efficiency of translation at a variety of start codons. Fusions using an ATG start site were the most active, whereas those using GTG and TTG were approximately one half or one fourth as active, respectively. The CTG fusion was 95% less active than the ATG fusion. « less

  1. INTEGRAL/RossiXTE high-energy observation of a state transition of GX 339-4

    E-Print Network [OSTI]

    T. Belloni; I. Parolin; M. Del Santo; J. Homan; P. Casella; R. P. Fender; W. H. G. Lewin; M. Mendez; J. M. Miller; M. van der Klis

    2006-01-02

    On 2004 August 15, we observed a fast (shorter than 10 hours) state transition in the bright black-hole transient GX 339-4 simultaneously with RossiXTE and INTEGRAL. This transition was evident both in timing and spectral properties. Combining the data from PCA, HEXTE and IBIS, we obtained good quality broad-band (3-200 keV) energy spectra before and after the transition. These spectra indicate that the hard component steepened. Also, the high-energy cutoff that was present at ~70 keV before the transition was not detected after the transition. This is the first time that an accurate determination of the broad-band spectrum across such a transition has been measured on a short time scale. It shows that, although some spectral parameters do not change abruptly through the transition, the high-energy cutoff increases/disappears rather fast. These results constitute a benchmark on which to test theoretical models for the production of the hard component in these systems.

  2. New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes forMethanosarcinaspecies

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Guss, Adam M.; Rother, Michael; Zhang, Jun Kai; Kulkkarni, Gargi; Metcalf, William W.

    2008-01-01

    A highly efficient method for chromosomal integration of cloned DNA intoMethanosarcina spp.was developed utilizing the site-specific recombination system from theStreptomycesphage ?C31. Host strains expressing the ?C31 integrase gene and carrying an appropriate recombination site can be transformed with non-replicating plasmids carrying the complementary recombination site at efficiencies similar to those obtained with self-replicating vectors. We have also constructed a series of hybrid promoters that combine the highly expressedM. barkeriPmcrBpromoter with binding sites for the tetracycline-responsive, bacterial TetR protein. These promoters are tightly regulated by the presence or absence of tetracycline in strains that express thetetRgene. The hybrid promoters can bemore »used in genetic experiments to test gene essentiality by placing a gene of interest under their control. Thus, growth of strains withtetR-regulated essential genes becomes tetracycline-dependent. A series of plasmid vectors that utilize the site-specific recombination system for construction of reporter gene fusions and for tetracycline regulated expression of cloned genes are reported. These vectors were used to test the efficiency of translation at a variety of start codons. Fusions using an ATG start site were the most active, whereas those using GTG and TTG were approximately one half or one fourth as active, respectively. The CTG fusion was 95% less active than the ATG fusion.« less

  3. Optimizing Throughput and Energy in Online Deadline Scheduling

    E-Print Network [OSTI]

    Wong, Prudence W.H.

    consider a processor that can vary its speed between 0 and a maximum speed T to minimize its energy usage usage. If we ignore energy usage, the best possible online algorithm is 4-competitive on throughput jobs; O(1)-competitive online algorithms with respect to energy usage have been known [Yao et al. 1995

  4. On the Throughput Capacity of Heterogeneous Wireless Networks

    E-Print Network [OSTI]

    Latchman, Haniph A.

    On the Throughput Capacity of Heterogeneous Wireless Networks Pan Li, Member, IEEE, and Yuguang of wireless networks. However, it is commonly assumed that all nodes in the network are identical. The issue of heterogeneous wireless networks with general network settings. Specifically, we consider an extended network

  5. Maximizing Throughput in Wireless Networks with Finite Internal Buffers

    E-Print Network [OSTI]

    Chang, Cheng-Shang

    Maximizing Throughput in Wireless Networks with Finite Internal Buffers Ching-Min Lien, Cheng of a discrete-time wireless network, where only certain sets of links can transmit simultaneously. It is well of the configuration vectors determines the capacity region of the wireless network. In the literature, packet

  6. Understanding TCP Incast Throughput Collapse in Datacenter Networks

    E-Print Network [OSTI]

    Joseph, Anthony D.

    Understanding TCP Incast Throughput Collapse in Datacenter Networks Yanpei Chen, Rean Griffith datacenters support a myriad of services and ap- plications. Companies like Google, Microsoft, Yahoo, and Amazon use datacenters for web search, storage, e-commerce, and large-scale general computations

  7. Storage Performance Virtualization via Throughput and Latency Control

    E-Print Network [OSTI]

    Riska, Alma

    Storage Performance Virtualization via Throughput and Latency Control JIANYONG ZHANG, ANAND storage systems. A consequence of this trend is the need to serve multiple users and/or workloads of the underlying storage system; (2) couple rate and latency allocation in a single scheduler, making them less

  8. FLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization

    E-Print Network [OSTI]

    Liblit, Ben

    the usefulness of flexible channels in the context of 802.11-based networks. Current 802.11 hardware can provideFLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization Shravan for designing 802.11 wireless LANs (WLANs) using flexible channelization -- the choice of an appropriate channel

  9. Thread Row Buffers: Improving Memory Performance Isolation and Throughput

    E-Print Network [OSTI]

    Tullsen, Dean M.

    and energy efficiency. Furthermore, concurrent execution of applications also has shown the needThread Row Buffers: Improving Memory Performance Isolation and Throughput in Multiprogrammed of performance isolation among threads in the memory controller to enforce a quality of service in virtualized

  10. Access Point Selection for Improving Throughput Fairness in Wireless LANs

    E-Print Network [OSTI]

    Siris, Vasilios A.

    Access Point Selection for Improving Throughput Fairness in Wireless LANs Vasilios A. Siris investigate the problem of access point selection in wireless LANs based on the IEEE 802.11 standard, when solely at the wireless stations, which passively monitor the activity of each access point's channel

  11. Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH)

    E-Print Network [OSTI]

    Rosen, Joseph

    Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH) using dual Montgomery County Campus, Rockville, Maryland 20850, USA * barakk@ee.bgu.ac.il Abstract: Fresnel incoherent Fresnel holography," Opt. Lett. 32(8), 912­914 (2007). 7. J. Rosen and G. Brooker, "Fluorescence

  12. Reliability and Throughput in Future Automotive Communication Networks

    E-Print Network [OSTI]

    Rajkumar, Ragunathan "Raj"

    Reliability and Throughput in Future Automotive Communication Networks John Liu, Timothy TaltyStar. This action created a new industry called automotive telematics, helping to save lives and providing, the automotive telematics industry has experienced a healthy growth in North America. During the current economic

  13. Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting

    E-Print Network [OSTI]

    Vaze, Rahul

    1 Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting Communication System general case of arbitrarily varying energy arrivals is considered, where neither the future energy arrival strategy that invests available energy uniformly over all remaining slots until the next energy arrival

  14. High-Throughput, High-Precision Hot Testing Tool for High-Brightness...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Diode Testing Lead Performer: KLA-Tencor Corporation - Milpitas, CA Partners: Ocean Optics - Dunedin, FL DOE Total Funding: 3,994,729 Cost Share: 4,626,422 Project Term: 815...

  15. Wireless Throughput and Energy Efficiency with Random Arrivals and Statistical Queueing Constraints

    E-Print Network [OSTI]

    Gursoy, Mustafa Cenk

    Wireless Throughput and Energy Efficiency with Random Arrivals and Statistical Queueing Constraints Mustafa Ozmen and M. Cenk Gursoy Abstract--Throughput and energy efficiency in fading channels are studied. Throughput is further studied in certain asymptotic regimes. Furthermore, energy efficiency is analyzed

  16. Project Profile: High Operating Temperature Liquid Metal Heat...

    Office of Environmental Management (EM)

    multi-target co-sputtering system to create massive compositional libraries in thin-film forms and employ high-throughput characterization methods to rapidly screen candidate...

  17. NREL Analysis: Cost-Effective and Reliable Integration of High-Penetration Solar in the Western United States (Poster)

    SciTech Connect (OSTI)

    Lew, D.; Brinkman, G.; Ibanez, E.; Hodge, B.; Lefton, S.; Kumar, N.; Agan, D.; Jordan, G.; Venkatataman, S.

    2012-07-01

    SunShot Initiative awardee posters describing the different technologies within the four subprograms of the DOE Solar Program (Photovoltaics, Concentrating Solar Power, Soft Costs, and Systems Integration).

  18. Fluidized-bed technology enabling the integration of high temperature solar receiver CSP systems with steam and advanced power cycles

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sakadjian, B.; Hu, S.; Maryamchik, M.; Flynn, T.; Santelmann, K.; Ma, Z.

    2015-05-01

    Solar Particle Receivers (SPR) are under development to drive concentrating solar plants (CSP) towards higher operating temperatures to support higher efficiency power conversion cycles. The novel high temperature SPR-based CSP system uses solid particles as the heat transfer medium (HTM) in place of the more conventional fluids such as molten salt or steam used in current state-of-the-art CSP plants. The solar particle receiver (SPR) is designed to heat the HTM to temperatures of 800 °C or higher which is well above the operating temperatures of nitrate-based molten salt thermal energy storage (TES) systems. The solid particles also help overcome somemore »of the other challenges associated with molten salt-based systems such as freezing, instability and degradation. The higher operating temperatures and use of low cost HTM and higher efficiency power cycles are geared towards reducing costs associated with CSP systems. This paper describes the SPR-based CSP system with a focus on the fluidized-bed (FB) heat exchanger and its integration with various power cycles. The SPR technology provides a potential pathway to achieving the levelized cost of electricity (LCOE) target of $0.06/kWh that has been set by the U.S. Department of Energy's SunShot initiative.« less

  19. HIGH-Q INTEGRATED INDUCTORS ON TRENCHED SILICON ISLANDS Mina Raieszadeh, Pejman Monajemi, Sang-Woong Yoon, Joy Laskar, and Farrokh Ayazi

    E-Print Network [OSTI]

    Ayazi, Farrokh

    HIGH-Q INTEGRATED INDUCTORS ON TRENCHED SILICON ISLANDS Mina Raieszadeh, Pejman Monajemi, Sang toxide Figure 1. Layout and equivalent electrical model of a planar spiral inductor. TRENCHED SI ISLAND by converting the electromagnetic energy into heat. Equations 2 and 3 show the components of the induced current

  20. Next Generation Packaging Architectures for Highly Integrated Wireless Systems J. Laskar, M. Tentzeris, A. Sutono, H. Liang, N.Bushyager and K. Lim

    E-Print Network [OSTI]

    Tentzeris, Manos

    Next Generation Packaging Architectures for Highly Integrated Wireless Systems J. Laskar, M. Tentzeris, A. Sutono, H. Liang, N.Bushyager and K. Lim etentze@ece.gatech.edu Packaging Research Center communication packaging architectures. In this paper, we include the design, implementation and measurement

  1. REDUCING THE ENVIRONMENTAL IMPACT OF HIGH-DENSITY FISH PRODUCTION: AN INTEGRATED APPROACH TO SOLIDS TREATMENT FOR RECIRCULATING

    E-Print Network [OSTI]

    waste discharges, improve quality control, and reduce costs. The crucial processes that must aquaculture systems (RASs) allow for systematic optimization of the environmental variables that control that integrate two or more of these processes. Expandable granular biofilters (EGBs) integrate solids capture

  2. An integrative computational approach for prioritization of genomic variants

    SciTech Connect (OSTI)

    Dubchak, Inna; Balasubramanian, Sandhya; Wang, Sheng; Meydan, Cem; Sulakhe, Dinanath; Poliakov, Alexander; Börnigen, Daniela; Xie, Bingqing; Taylor, Andrew; Ma, Jianzhu; Paciorkowski, Alex R.; Mirzaa, Ghayda M.; Dave, Paul; Agam, Gady; Xu, Jinbo; Al-Gazali, Lihadh; Mason, Christopher E.; Ross, M. Elizabeth; Maltsev, Natalia; Gilliam, T. Conrad; Huang, Qingyang

    2014-12-15

    An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB), and the RaptorX server, for the identification of high-confidence candidate genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest.

  3. An integrative computational approach for prioritization of genomic variants

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dubchak, Inna; Balasubramanian, Sandhya; Wang, Sheng; Meydan, Cem; Sulakhe, Dinanath; Poliakov, Alexander; Börnigen, Daniela; Xie, Bingqing; Taylor, Andrew; Ma, Jianzhu; et al

    2014-12-15

    An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB), and the RaptorX server, for the identification of high-confidence candidatemore »genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest.« less

  4. High Efficiency Integrated Space Conditioning, Water Heating and Air Distribution System for HUD-Code Manufactured Housing

    SciTech Connect (OSTI)

    Henry DeLima; Joe Akin; Joseph Pietsch

    2008-09-14

    Recognizing the need for new space conditioning and water heating systems for manufactured housing, DeLima Associates assembled a team to develop a space conditioning system that would enhance comfort conditions while also reducing energy usage at the systems level. The product, Comboflair® was defined as a result of a needs analysis of project sponsors and industry stakeholders. An integrated system would be developed that would combine a packaged airconditioning system with a small-duct, high-velocity air distribution system. In its basic configuration, the source for space heating would be a gas water heater. The complete system would be installed at the manufactured home factory and would require no site installation work at the homesite as is now required with conventional split-system air conditioners. Several prototypes were fabricated and tested before a field test unit was completed in October 2005. The Comboflair® system, complete with ductwork, was installed in a 1,984 square feet, double-wide manufactured home built by Palm Harbor Homes in Austin, TX. After the home was transported and installed at a Palm Harbor dealer lot in Austin, TX, a data acquisition system was installed for remote data collection. Over 60 parameters were continuously monitored and measurements were transmitted to a remote site every 15 minutes for performance analysis. The Comboflair® system was field tested from February 2006 until April 2007. The cooling system performed in accordance with the design specifications. The heating system initially could not provide the needed capacity at peak heating conditions until the water heater was replaced with a higher capacity standard water heater. All system comfort goals were then met. As a result of field testing, we have identified improvements to be made to specific components for incorporation into production models. The Comboflair® system will be manufactured by Unico, Inc. at their new production facility in St. Louis, MO. The product will be initially launched in the hot-humid climates of the southern U.S.

  5. Plasmonic Antenna Integrated Quantum Cascade Laser for Mode Confinement used for High Sensitivity Bio-Sensing Applications

    E-Print Network [OSTI]

    Mohseni, Hooman

    structure on the facet of the Quantum Cascade Laser. We have previously developed such composite material . The design has been optimized using full 3D- Finite-difference-time-domain (FDTD) simulations. The antenna integrated Quantum Cascade Laser where the optical mode has been squeezed within ~ 100nm and its interaction

  6. Sandia Energy - Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis ofSample SULIColinEnergy PolicyLeaksDETL Permalink Gallery

  7. Sandia Energy - Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis ofSample SULIColinEnergy PolicyLeaksDETL Permalink

  8. Sandia Energy - Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis ofSample SULIColinEnergy PolicyLeaksDETL PermalinkDETL

  9. Extending molecular simulation time scales: Parallel in time integrations for high-level quantum chemistry and complex force representations

    SciTech Connect (OSTI)

    Bylaska, Eric J.; Weare, Jonathan Q.; Weare, John H.

    2013-08-21

    Parallel in time simulation algorithms are presented and applied to conventional molecular dynamics (MD) and ab initio molecular dynamics (AIMD) models of realistic complexity. Assuming that a forward time integrator, f (e.g., Verlet algorithm), is available to propagate the system from time t{sub i} (trajectory positions and velocities x{sub i} = (r{sub i}, v{sub i})) to time t{sub i+1} (x{sub i+1}) by x{sub i+1} = f{sub i}(x{sub i}), the dynamics problem spanning an interval from t{sub 0}…t{sub M} can be transformed into a root finding problem, F(X) = [x{sub i} ? f(x{sub (i?1})]{sub i} {sub =1,M} = 0, for the trajectory variables. The root finding problem is solved using a variety of root finding techniques, including quasi-Newton and preconditioned quasi-Newton schemes that are all unconditionally convergent. The algorithms are parallelized by assigning a processor to each time-step entry in the columns of F(X). The relation of this approach to other recently proposed parallel in time methods is discussed, and the effectiveness of various approaches to solving the root finding problem is tested. We demonstrate that more efficient dynamical models based on simplified interactions or coarsening time-steps provide preconditioners for the root finding problem. However, for MD and AIMD simulations, such preconditioners are not required to obtain reasonable convergence and their cost must be considered in the performance of the algorithm. The parallel in time algorithms developed are tested by applying them to MD and AIMD simulations of size and complexity similar to those encountered in present day applications. These include a 1000 Si atom MD simulation using Stillinger-Weber potentials, and a HCl + 4H{sub 2}O AIMD simulation at the MP2 level. The maximum speedup ((serial execution time)/(parallel execution time) ) obtained by parallelizing the Stillinger-Weber MD simulation was nearly 3.0. For the AIMD MP2 simulations, the algorithms achieved speedups of up to 14.3. The parallel in time algorithms can be implemented in a distributed computing environment using very slow transmission control protocol/Internet protocol networks. Scripts written in Python that make calls to a precompiled quantum chemistry package (NWChem) are demonstrated to provide an actual speedup of 8.2 for a 2.5 ps AIMD simulation of HCl + 4H{sub 2}O at the MP2/6-31G* level. Implemented in this way these algorithms can be used for long time high-level AIMD simulations at a modest cost using machines connected by very slow networks such as WiFi, or in different time zones connected by the Internet. The algorithms can also be used with programs that are already parallel. Using these algorithms, we are able to reduce the cost of a MP2/6-311++G(2d,2p) simulation that had reached its maximum possible speedup in the parallelization of the electronic structure calculation from 32 s/time step to 6.9 s/time step.

  10. Thickness effects on fracture toughness of ultra-high-molecular- weight polyethylene via the J-integral 

    E-Print Network [OSTI]

    Lehmann, Jarvis Craig

    1992-01-01

    in existence. Very little has been reported in the literature concerning fracture of UHMW-PE. This paper reports a study of thickness effects on mode I fracture toughness of a compression molded UHMW-PE plate material via the J-integral. Six sets... . . . 9 5 . . . . 1 2 2 . . . . 1 5 7 V DISCUSSION OF RESULTS. . . . . 1 8 1 UHMW-PE AS RECEIVED MATERIAL. MOLECULAR WEIGHT. DENSITY TENSILE PROPERTIES . . Rate Effects Plate Thru Thickness Effects. . FRACTURE TOUGHNESS . . . . . Plate Thru...

  11. Sandia Energy - Distribution Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis ofSample SULIColin Humphreys

  12. A Persistent High-Energy Flux from the Heart of the Milky Way : Integral's view of the Galactic Center

    E-Print Network [OSTI]

    Guillaume Belanger; Andrea Goldwurm; Matthieu Renaud; Regis Terrier; Fulvio Melia; Niels Lund; Jacques Paul; Gerry Skinner; Farah Yusef-Zadeh

    2005-08-04

    The Ibis/Isgri imager on Integral detected for the first time a hard X-ray source, IGR J17456-2901, located within 1' of Sgr A* over the energy range 20-100 keV. Here we present the results of a detailed analysis of ~7 Ms of Integral observations of the GC. With an effective exposure of 4.7 Ms we have obtained more stringent positional constraints on this HE source and constructed its spectrum in the range 20-400 keV. Furthermore, by combining the Isgri spectrum with the total X-ray spectrum corresponding to the same physical region around SgrA* from XMM data, and collected during part of the Integral observations, we constructed and present the first accurate wide band HE spectrum for the central arcmins of the Galaxy. Our complete analysis of the emission properties of IGR shows that it is faint but persistent with no variability above 3 sigma contrary to what was alluded to in our first paper. This result, in conjunction with the spectral characteristics of the X-ray emission from this region, suggests that the source is most likely not point-like but, rather, that it is a compact, yet diffuse, non-thermal emission region. The centroid of IGR is estimated to be R.A.=17h45m42.5, decl.=-28deg59'28'', offset by 1' from the radio position of Sgr A* and with a positional uncertainty of 1'. Its 20-400 keV luminosity at 8 kpc is L=5.4x10^35 erg/sec. Very recently, Hess detected of a source of ~TeV g-rays also located within 1' of Sgr A*. We present arguments in favor of an interpretation according to which the photons detected by Integral and Hess arise from the same compact region of diffuse emission near the central BH and that the supernova remnant Sgr A East could play an important role as a contributor of very HE g-rays to the overall spectrum from this region.

  13. Eastern Renewable Generation Integration Study: Flexibility and High Penetrations of Wind and Solar; NREL (National Renewable Energy Laboratory)

    SciTech Connect (OSTI)

    Bloom, Aaron; Townsend, Aaron; Palchak, David

    2015-07-29

    Balancing wind and solar in a model is relatively easy. All you need to do is assume a very large system with infinite flexibility! But what if you don't have an infinitely flexible system? What if there are thousands of generators nestled in a handful of regions that are unlikely to change their operational practices? Would you still have enough flexibility to balance hundreds of gigawatts of wind and solar at a 5 minute level? At NREL, we think we can, and our industry partners agree. This presentation was presented at the IEEE Power and Energy Society General Meeting by Aaron Bloom, highlighting results of the Eastern Renewable Generation Integration Study.

  14. Bayesian Model Selection for High-dimensional High-throughput Data 

    E-Print Network [OSTI]

    Joshi, Adarsh

    2012-07-16

    , the 10 g-prior corresponds to an alternative distribution of the following form: H ?2 : ? ? N(0, c n ). (2.5) Hence the expression for the corresponding Bayes? factor can be written as BF (2|1) = ?(Y? , 0, (c + 1)/n) ?(Y? , 0, 1/n) = 1 (c + 1... to the interval (a, a) by MoM prior centered on 0 with scale ? and n = 1 is 2 [ ? ( a ? ? ) ? a ? 2pi? exp ( ? a2 2? ) ? 1 2 ] . (2.21) 17 For an iMoM prior, the corresponding probability is 1?G [ (a/ ? ?)?2k; ? 2k , 1 ] , (2...

  15. High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets

    E-Print Network [OSTI]

    Wang, Benjamin L. (Benjamin Lu chen)

    2009-01-01

    Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...

  16. High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells

    DOE Patents [OSTI]

    Daniel, Claus; Blue, Craig A.; Ott, Ronald D.

    2014-08-19

    Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.

  17. Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based

    E-Print Network [OSTI]

    Rosenberg, Catherine P.

    1 Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based Interference crucial design objectives for a number of multihop wireless network applica- tions. As these two this tradeoff between the network throughput and lifetime, for the case of fixed wireless networks where link

  18. Maximizing Throughput of UAV-Relaying Networks with the Load-Carry-and-Deliver Paradigm

    E-Print Network [OSTI]

    Kung, H. T.

    Maximizing Throughput of UAV-Relaying Networks with the Load-Carry-and-Deliver Paradigm Chen Unmanned Aerial Vehicles (UAVs) to relay messages between two distant ground nodes. For delay-tolerant applications like latency-insensitive bulk data transfer, we seek to maximize throughput by having a UAV load

  19. Throughput Optimal Task Allocation under Thermal Constraints for Multi-core Processors

    E-Print Network [OSTI]

    Chatha, Karam S.

    Throughput Optimal Task Allocation under Thermal Constraints for Multi-core Processors Vinay and thermal hotspots affect the reliability of microprocessors. Temperature is also an important constraint. In this paper, we formulate the problem of throughput-optimal task allocation on thermally constrained multi

  20. A Switch-Based Approach to Throughput Collapse and Starvation in Data Centers Alexander Shpiner

    E-Print Network [OSTI]

    Keslassy, Isaac

    A Switch-Based Approach to Throughput Collapse and Starvation in Data Centers Alexander Shpiner on small switch buffers. However, in case of congestion, data center switches may suffer from throughput link. Last, HCF also prevents packet reordering. Key words: TCP, Data centers, Switching. 1

  1. A Switch-Based Approach to Throughput Collapse and Starvation in Data Centers

    E-Print Network [OSTI]

    Keslassy, Isaac

    A Switch-Based Approach to Throughput Collapse and Starvation in Data Centers Alexander Shpiner, 32000, Israel {shalex@tx, isaac@ee}.technion.ac.il Abstract--Data center switches need to satisfy, in case of congestion, data center switches can incur throughput collapse for short TCP flows as well

  2. New Findings on Using Queue Occupancy to Integrate Runtime Power-Saving Techniques Across the Pipeline

    E-Print Network [OSTI]

    Huang, Wei

    New Findings on Using Queue Occupancy to Integrate Runtime Power-Saving Techniques Across provides new insights on how to integrate power-saving techniques by using queue occupancies to dynamically match the power-saving modes of various pipeline stages with the current instruction throughput. (This

  3. Low-temperature germanium ultra-high vacuum chemical vapor deposition for back-end photonic integration

    E-Print Network [OSTI]

    Kimerling, Lionel C.

    Polycrystalline germanium (poly-Ge) grown on amorphous Si (a-Si) by ultra-high vacuum chemical vapor deposition (UHVCVD) over oxide barriers at low temperatures (Tles450degC) exhibits a larger grain size and lower defect ...

  4. Development of an Integrated Raman and Turbidity Fiber Optic Sensor for the In-Situ Analysis of High Level Nuclear Waste

    SciTech Connect (OSTI)

    Gasbarro, Christina; Bello, Job M.; Bryan, Samuel A.; Lines, Amanda M.; Levitskaia, Tatiana G.

    2013-02-24

    Stored nuclear waste must be retrieved from storage, treated, separated into low- and high-level waste streams, and finally put into a disposal form that effectively encapsulates the waste and isolates it from the environment for a long period of time. Before waste retrieval can be done, waste composition needs to be characterized so that proper safety precautions can be implemented during the retrieval process. In addition, there is a need for active monitoring of the dynamic chemistry of the waste during storage since the waste composition can become highly corrosive. This work describes the development of a novel, integrated fiber optic Raman and light scattering probe for in situ use in nuclear waste solutions. The dual Raman and turbidity sensor provides simultaneous chemical identification of nuclear waste as well as information concerning the suspended particles in the waste using a common laser excitation source.

  5. Development of an Integrated Raman and Turbidity Fiber Optic Sensor for the In-Situ Analysis of High Level Nuclear Waste - 13532

    SciTech Connect (OSTI)

    Gasbarro, Christina; Bello, Job [EIC Laboratories, Inc., 111 Downey St., Norwood, MA, 02062 (United States)] [EIC Laboratories, Inc., 111 Downey St., Norwood, MA, 02062 (United States); Bryan, Samuel; Lines, Amanda; Levitskaia, Tatiana [Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352 (United States)] [Pacific Northwest National Laboratory, PO Box 999, Richland, WA, 99352 (United States)

    2013-07-01

    Stored nuclear waste must be retrieved from storage, treated, separated into low- and high-level waste streams, and finally put into a disposal form that effectively encapsulates the waste and isolates it from the environment for a long period of time. Before waste retrieval can be done, waste composition needs to be characterized so that proper safety precautions can be implemented during the retrieval process. In addition, there is a need for active monitoring of the dynamic chemistry of the waste during storage since the waste composition can become highly corrosive. This work describes the development of a novel, integrated fiber optic Raman and light scattering probe for in situ use in nuclear waste solutions. The dual Raman and turbidity sensor provides simultaneous chemical identification of nuclear waste as well as information concerning the suspended particles in the waste using a common laser excitation source. (authors)

  6. ORCID-opoly, Where High-touch Meets High-Tech: Learning and Outreach efforts in support of ORCID Integration at Texas A&M 

    E-Print Network [OSTI]

    Clement, Gail

    2014-05-23

    In February 2014, Texas A&M minted ORCiDs for 10,000+ graduate students as an ORCID member organization. In the first 9 days, about 2000 students claimed their ORCIDs, demonstrating that high tech alone is not sufficient to reach and engage campus...

  7. High Performance Interconnect System Design for Future Chip Multiprocessors 

    E-Print Network [OSTI]

    Wang, Lei

    2013-05-02

    constraints of power and area, and provide ultra low latencies and high throughput. In this research, we explore different techniques to design high performance NOC. First, existing NOCs mostly use Dimension Order Routing (DOR) to determine the route taken...

  8. Marine High Voltage Power Conditioning and Transmission System with Integrated Storage DE-EE0003640 Final Report

    SciTech Connect (OSTI)

    Frank Hoffmann, PhD; Aspinall, Rik

    2012-12-10

    Design, Development, and test of the three-port power converter for marine hydrokinetic power transmission. Converter provides ports for AC/DC conversion of hydrokinetic power, battery storage, and a low voltage to high voltage DC port for HVDC transmission to shore. The report covers the design, development, implementation, and testing of a prototype built by PPS.

  9. Highly-enhanced reflow characteristics of sputter deposited Cu alloy thin films for large scale integrated interconnections

    SciTech Connect (OSTI)

    Onishi, Takashi; Mizuno, Masao; Yoshikawa, Tetsuya; Munemasa, Jun; Mizuno, Masataka; Kihara, Teruo; Araki, Hideki; Shirai, Yasuharu

    2011-08-01

    An attempt to improve the reflow characteristics of sputtered Cu films was made by alloying the Cu with various elements. We selected Y, Sb, Nd, Sm, Gd, Dy, In, Sn, Mg, and P for the alloys, and ''the elasto-plastic deformation behavior at high temperature'' and ''the filling level of Cu into via holes'' were estimated for Cu films containing each of these elements. From the results, it was found that adding a small amount of Sb or Dy to the sputtered Cu was remarkably effective in improve the reflow characteristics. The microstructure and imperfections in the Cu films before and after high-temperature high-pressure annealing were investigated by secondary ion micrographs and positron annihilation spectroscopy. The results imply that the embedding or deformation mechanism is different for the Cu-Sb alloy films compared to the Cu-Dy alloy films. We consider that the former is embedded by softening or deformation of the Cu matrix, which has a polycrystalline structure, and the latter is embedded by grain boundary sliding.

  10. ILP provides probabilistic upper and lower bounds that improve over time and are often tighter than variational methods The curse of dimensionality for high-dimensional integration

    E-Print Network [OSTI]

    Thrun, Sebastian

    .g., 100 dimensions, sum over 2100 ~ 1030 items) pseudocode Discrete Integration WISH: Approximate Discrete

  11. New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional Integration

    E-Print Network [OSTI]

    Jeong, Jong Cheol

    2013-05-31

    issues of processing Big data due to the explosion of publicly available genomic information resulted from the Human Genome Project (HGP) and the increasing usage of high throughput technology. HGP was completed in 2003 and resulted in identifying 20...

  12. ExperiBase : an integrated software architecture to support modern experimental biology

    E-Print Network [OSTI]

    Zhang, Shixin, 1970-

    2004-01-01

    Over the past several years, the explosive growth of biological data generated by new high-throughput instruments has virtually begun to drown the biological community. There is no established infrastructure to deal with ...

  13. Photovoltaic manufacturing cost and throughput improvements for thin-film CIGS-based modules: Phase 1 technical report, July 1998--July 1999

    SciTech Connect (OSTI)

    Wiedeman, S.; Wendt, R.G.

    2000-03-01

    The primary objectives of the Global Solar Energy (GSE) Photovoltaic Manufacturing Technology (PVMaT) subcontract are directed toward reducing cost and expanding the production rate of thin-film CuInGaSe{sub 2} (CIGS)-based PV modules on flexible substrates. Improvements will be implemented in monolithic integration, CIGS deposition, contact deposition, and in-situ CIGS control and monitoring. In Phase 1, GSE has successfully attacked many of the highest risk aspects of each task. All-laser, selective scribing processes for CIGS have been developed, and many end-of-contract goals for scribing speed have been exceeded in the first year. High-speed ink-jet deposition of insulating material in the scribes now appears to be a viable technique, again exceeding some end-of-contract goals in the first year. Absorber deposition of CIGS was reduced corresponding to throughput speeds of up to 24-in/min, also exceeding an end-of-contract goal. Alternate back-contact materials have been identified that show potential as candidates for replacement of higher-cost molybdenum, and a novel, real-time monitoring technique (parallel-detector spectroscopic ellipsometry) has shown remarkable sensitivity to relevant properties of the CIGS absorber layer for use as a diagnostic tool. Currently, one of the bilayers has been baselined by GSE for flexible CIGS on polymeric substrates. Resultant back-contacts meet sheet-resistance goals and exhibit much less intrinsic stress than Mo. CIGS has been deposited, and resultant devices are comparable in performance to pure Mo back-contacts. Debris in the chamber has been substantially reduced, allowing longer roll-length between system cleaning.

  14. A High-Performance VLSI Architecture for Advanced Encryption Standard (AES) Algorithm

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    A High-Performance VLSI Architecture for Advanced Encryption Standard (AES) Algorithm Naga M technology resulted in a throughput of 232Mbps for iterative architecture and 1.83Gbps for pipelining implementation. The proposed architecture is optimized for high throughput in terms of the encryption

  15. Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC) : gap analysis for high fidelity and performance assessment code development.

    SciTech Connect (OSTI)

    Lee, Joon H.; Siegel, Malcolm Dean; Arguello, Jose Guadalupe, Jr.; Webb, Stephen Walter; Dewers, Thomas A.; Mariner, Paul E.; Edwards, Harold Carter; Fuller, Timothy J.; Freeze, Geoffrey A.; Jove-Colon, Carlos F.; Wang, Yifeng

    2011-03-01

    This report describes a gap analysis performed in the process of developing the Waste Integrated Performance and Safety Codes (IPSC) in support of the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The goal of the Waste IPSC is to develop an integrated suite of computational modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with rigorous verification, validation, and software quality requirements. The gap analyses documented in this report were are performed during an initial gap analysis to identify candidate codes and tools to support the development and integration of the Waste IPSC, and during follow-on activities that delved into more detailed assessments of the various codes that were acquired, studied, and tested. The current Waste IPSC strategy is to acquire and integrate the necessary Waste IPSC capabilities wherever feasible, and develop only those capabilities that cannot be acquired or suitably integrated, verified, or validated. The gap analysis indicates that significant capabilities may already exist in the existing THC codes although there is no single code able to fully account for all physical and chemical processes involved in a waste disposal system. Large gaps exist in modeling chemical processes and their couplings with other processes. The coupling of chemical processes with flow transport and mechanical deformation remains challenging. The data for extreme environments (e.g., for elevated temperature and high ionic strength media) that are needed for repository modeling are severely lacking. In addition, most of existing reactive transport codes were developed for non-radioactive contaminants, and they need to be adapted to account for radionuclide decay and in-growth. The accessibility to the source codes is generally limited. Because the problems of interest for the Waste IPSC are likely to result in relatively large computational models, a compact memory-usage footprint and a fast/robust solution procedure will be needed. A robust massively parallel processing (MPP) capability will also be required to provide reasonable turnaround times on the analyses that will be performed with the code. A performance assessment (PA) calculation for a waste disposal system generally requires a large number (hundreds to thousands) of model simulations to quantify the effect of model parameter uncertainties on the predicted repository performance. A set of codes for a PA calculation must be sufficiently robust and fast in terms of code execution. A PA system as a whole must be able to provide multiple alternative models for a specific set of physical/chemical processes, so that the users can choose various levels of modeling complexity based on their modeling needs. This requires PA codes, preferably, to be highly modularized. Most of the existing codes have difficulties meeting these requirements. Based on the gap analysis results, we have made the following recommendations for the code selection and code development for the NEAMS waste IPSC: (1) build fully coupled high-fidelity THCMBR codes using the existing SIERRA codes (e.g., ARIA and ADAGIO) and platform, (2) use DAKOTA to build an enhanced performance assessment system (EPAS), and build a modular code architecture and key code modules for performance assessments. The key chemical calculation modules will be built by expanding the existing CANTERA capabilities as well as by extracting useful components from other existing codes.

  16. Integrated Operation of INL HYTEST System and High-Temperature Steam Electrolysis for Synthetic Natural Gas Production

    SciTech Connect (OSTI)

    Carl Marcel Stoots; Lee Shunn; James O'Brien

    2010-06-01

    The primary feedstock for synthetic fuel production is syngas, a mixture of carbon monoxide and hydrogen. Current hydrogen production technologies rely upon fossil fuels and produce significant quantities of greenhouse gases as a byproduct. This is not a sustainable means of satisfying future hydrogen demands, given the current projections for conventional world oil production and future targets for carbon emissions. For the past six years, the Idaho National Laboratory has been investigating the use of high-temperature steam electrolysis (HTSE) to produce the hydrogen feedstock required for synthetic fuel production. High-temperature electrolysis water-splitting technology, combined with non-carbon-emitting energy sources, can provide a sustainable, environmentally-friendly means of large-scale hydrogen production. Additionally, laboratory facilities are being developed at the INL for testing hybrid energy systems composed of several tightly-coupled chemical processes (HYTEST program). The first such test involved the coupling of HTSE, CO2 separation membrane, reverse shift reaction, and methanation reaction to demonstrate synthetic natural gas production from a feedstock of water and either CO or a simulated flue gas containing CO2. This paper will introduce the initial HTSE and HYTEST testing facilities, overall coupling of the technologies, testing results, and future plans.

  17. Box Integrals

    E-Print Network [OSTI]

    Bailey, David H.; Borwein, Jonathan M.; Crandall, Richard E.

    2006-01-01

    Box integrals D.H. Bailey ? J.M. Borwein † April 3,Abstract. By a “box integral” we mean here an expectation |r· dr n . The study of box integrals leads one naturally into

  18. Efficient Nanoporous Silicon Membranes for Integrated Microfluidic Separation and Sensing Systems

    SciTech Connect (OSTI)

    Ileri, N; L?tant, S E; Britten, J; Nguyen, H; Larson, C; Zaidi, S; Palazoglu, A; Faller, R; Tringe, J W; Stroeve, P

    2009-04-06

    Nanoporous devices constitute emerging platforms for selective molecule separation and sensing, with great potential for high throughput and economy in manufacturing and operation. Acting as mass transfer diodes similar to a solid-state device based on electron conduction, conical pores are shown to have superior performance characteristics compared to traditional cylindrical pores. Such phenomena, however, remain to be exploited for molecular separation. Here we present performance results from silicon membranes created by a new synthesis technique based on interferometric lithography. This method creates millimeter sized planar arrays of uniformly tapered nanopores in silicon with pore diameter 100 nm or smaller, ideally-suited for integration into a multi-scale microfluidic processing system. Molecular transport properties of these devices are compared against state-of-the-art polycarbonate track etched (PCTE) membranes. Mass transfer rates of up to fifteen-fold greater than commercial sieve technology are obtained. Complementary results from molecular dynamics simulations on molecular transport are reported.

  19. TRIPLE INTEGRALS Studying triple integrals

    E-Print Network [OSTI]

    Knopf, Dan

    TRIPLE INTEGRALS Studying triple integrals of functions of three variables is a natural step up from the two variable case. It's a very important one for applications. Now the domain of integration in 3- space as double integrals, which in turn were expressed as repeated integrals. As a result

  20. Asymptotic Throughput of the FED-STD-1052 Data Link Protocol Eric E. Johnson

    E-Print Network [OSTI]

    Johnson, Eric E.

    Asymptotic Throughput of the FED-STD-1052 Data Link Protocol Eric E. Johnson New Mexico State. · Diurnal and seasonal variations in usable channels from hour to hour and day to day. · Solar cycle effects

  1. Beyond Proportional Fairness: A Resource Biasing Framework for Shaping Throughput Profiles in

    E-Print Network [OSTI]

    Belding-Royer, Elizabeth M.

    Beyond Proportional Fairness: A Resource Biasing Framework for Shaping Throughput Profiles of resources. While proportional fair allocation provides a significant improvement, we point out here connections than max-min fair or proportional fair resource allocations, with minimal impact

  2. Throughput Performance of Quantized Proportional Fair Scheduling with Adaptive Modulation and

    E-Print Network [OSTI]

    Ishizaki, Fumio

    Throughput Performance of Quantized Proportional Fair Scheduling with Adaptive Modulation where QPF (Quantized Proportional Fair) scheduling and AMC (adaptive modulation and coding) scheme condition [11]. To solve this unfair problem, the proportional fair (PF) scheduling was proposed where

  3. Throughput Optimal Scheduling in the Presence of Heavy-Tailed Traffic

    E-Print Network [OSTI]

    Jagannathan, Krishna Prasanna

    We investigate the tail behavior of the steady-state queue occupancies under throughput optimal scheduling in the presence of heavy-tailed traffic. We consider a system consisting of two parallel queues, served by a single ...

  4. Map Task Scheduling in MapReduce with Data Locality: Throughput and Heavy-Traffic Optimality

    E-Print Network [OSTI]

    Zhang, Junshan

    is throughput optimal and the outer bound coincides with the actual capacity region. Further, we study in a distributed and parallel fashion, and has been widely used in practice, including Google, Yahoo!, Facebook

  5. Characteristics of high-rate energy spectroscopy systems using HPGe coaxial detectors and time-variant filters

    SciTech Connect (OSTI)

    Britton, C.L.; Becker, T.H.; Paulus, T.J.; Trammell, R.C.

    1984-02-01

    A high-rate, high-resolution gamma spectrometer system is described. The system consists of a reverse electrode HPGe coaxial detector, a transistor reset preamplifier, an active, semi-Gaussian prefilter, a gated integrator, and a unique data acquisition system consisting of a 10 ..mu..s, 13 bit ADC, fast FIFO memory, 8k by 23 bit data memory, and computer interface circuitry under the control of a Z-80A ..mu..P. The effects of the various components on the throughput are described and throughput data is presented. The resolution and peak shift for various shaping times are presented for count rates up to 1 Mcps input rate using a mixed /sup 22/Na and /sup 60/Co source. The low rate resolutions of /sup 57/Co and /sup 60/Co for various shaping times using either the semi-Gaussian or gated integrator output are discussed as well as the low energy resolution and peak shifts in the presence of high energy events.

  6. Sandia Energy - Distribution Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput Analysis ofSample SULIColin HumphreysDETL Permalink Gallery

  7. Sandia Energy - Transmission Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput AnalysisSinkholeCapabilities General overview of

  8. Sandia Energy » Grid Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-Throughput AnalysisSinkholeCapabilitiesTheSandiansDOENaturalParticipated

  9. A frequency and sensitivity tunable microresonator array for high-speed quantum processor readout

    E-Print Network [OSTI]

    Whittaker, J D; Volkmann, M H; Spear, P; Altomare, F; Berkley, A J; Bumble, B; Bunyk, P; Day, P K; Eom, B H; Harris, R; Hilton, J P; Hoskinson, E; Johnson, M W; Kleinsasser, A; Ladizinsky, E; Lanting, T; Oh, T; Perminov, I; Tolkacheva, E; Yao, J

    2015-01-01

    Superconducting microresonators have been successfully utilized as detection elements for a wide variety of applications. With multiplexing factors exceeding 1,000 detectors per transmission line, they are the most scalable low-temperature detector technology demonstrated to date. For high-throughput applications, fewer detectors can be coupled to a single wire but utilize a larger per-detector bandwidth. For all existing designs, fluctuations in fabrication tolerances result in a non-uniform shift in resonance frequency and sensitivity, which ultimately limits the efficiency of band-width utilization. Here we present the design, implementation, and initial characterization of a superconducting microresonator readout integrating two tunable inductances per detector. We demonstrate that these tuning elements provide independent control of both the detector frequency and sensitivity, allowing us to maximize the transmission line bandwidth utilization. Finally we discuss the integration of these detectors in a m...

  10. Cluster Computing: High-Performance, High-Availability, and High-Throughput Processing on a Network of Computers

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Laboratory Dept. of Computer Science and Software Engineering The University of Melbourne, Australia {csyeo, raj}@cs.mu.oz.au 2 Parallel and Distributed Systems Laboratory Department of Computer Science for cluster computing was developed in the 1960s by IBM as an alternative of linking large mainframes

  11. A compression scheme for radio data in high performance computing

    E-Print Network [OSTI]

    Masui, Kiyoshi; Connor, Liam; Deng, Meiling; Fandino, Mateus; Höfer, Carolin; Halpern, Mark; Hanna, David; Hincks, Adam D; Hinshaw, Gary; Parra, Juan Mena; Newburgh, Laura B; Shaw, J Richard; Vanderlinde, Keith

    2015-01-01

    We present a procedure for efficiently compressing astronomical radio data for high performance applications. Integrated, post-correlation data are first passed through a nearly lossless rounding step which compares the precision of the data to a generalized and calibration-independent form of the radiometer equation. This allows the precision of the data to be reduced in a way that has an insignificant impact on the data. The newly developed Bitshuffle lossless compression algorithm is subsequently applied. When the algorithm is used in conjunction with the HDF5 library and data format, data produced by the CHIME Pathfinder telescope is compressed to 28% of its original size and decompression throughputs in excess of 1 GB/s are obtained on a single core.

  12. Grid Integration

    SciTech Connect (OSTI)

    Not Available

    2008-09-01

    Summarizes the goals and activities of the DOE Solar Energy Technologies Program efforts within its grid integration subprogram.

  13. HLW System Integrated Project Team

    Office of Environmental Management (EM)

    Team Integrated Project Team Steve Schneider Steve Schneider Office of Engineering and Technology High Level Waste Corporate Board March 5, 2009 This document is intended for...

  14. A Deeply Pipelined CABAC Decoder for HEVC Supporting Level 6.2 High-tier Applications

    E-Print Network [OSTI]

    Chen, Yu-Hsin

    High Efficiency Video Coding (HEVC) is the latest video coding standard that specifies video resolutions up to 8K Ultra-HD (UHD) at 120 fps to support the next decade of video applications. This results in high-throughput ...

  15. Atomic-Layer-Deposited High-k Dielectric Integration on Epitaxial Graphene P.D. Ye, A.T. Neal, T. Shen, J.J. Gu, M.L. Bolen, and M. A. Capano

    E-Print Network [OSTI]

    Ye, Peide "Peter"

    for suspended CNT and graphene. There are three main preparation strategies for graphene, resulting in differentAtomic-Layer-Deposited High-k Dielectric Integration on Epitaxial Graphene P.D. Ye, A.T. Neal, T, III-V semiconductors, carbon nanotubes (CNTs) and graphene. Perfect top-gate dielectric stacks

  16. Mapping intra-field yield variation using high resolution satellite imagery to integrate bioenergy and environmental stewardship in an agricultural watershed

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hamada, Yuki; Ssegane, Herbert; Negri, Maria Cristina

    2015-07-31

    Biofuels are important alternatives for meeting our future energy needs. Successful bioenergy crop production requires maintaining environmental sustainability and minimum impacts on current net annual food, feed, and fiber production. The objectives of this study were to: (1) determine under-productive areas within an agricultural field in a watershed using a single date; high resolution remote sensing and (2) examine impacts of growing bioenergy crops in the under-productive areas using hydrologic modeling in order to facilitate sustainable landscape design. Normalized difference indices (NDIs) were computed based on the ratio of all possible two-band combinations using the RapidEye and the National Agriculturalmore »Imagery Program images collected in summer 2011. A multiple regression analysis was performed using 10 NDIs and five RapidEye spectral bands. The regression analysis suggested that the red and near infrared bands and NDI using red-edge and near infrared that is known as the red-edge normalized difference vegetation index (RENDVI) had the highest correlation (R2 = 0.524) with the reference yield. Although predictive yield map showed striking similarity to the reference yield map, the model had modest correlation; thus, further research is needed to improve predictive capability for absolute yields. Forecasted impact using the Soil and Water Assessment Tool model of growing switchgrass (Panicum virgatum) on under-productive areas based on corn yield thresholds of 3.1, 4.7, and 6.3 Mg·ha-1 showed reduction of tile NO3-N and sediment exports by 15.9%–25.9% and 25%–39%, respectively. Corresponding reductions in water yields ranged from 0.9% to 2.5%. While further research is warranted, the study demonstrated the integration of remote sensing and hydrologic modeling to quantify the multifunctional value of projected future landscape patterns in a context of sustainable bioenergy crop production.« less

  17. Eastern Renewable Generation Integration Study (Presentation)

    SciTech Connect (OSTI)

    Bloom, A.

    2014-05-01

    This presentation provides a high-level overview of the Eastern Renewable Generation Integration Study process, scenarios, tools, and goals.

  18. Experimental Approach of a High Performance Control of Two PermanentMagnet Synchronous Machines in an Integrated Drive for Automotive Applications

    SciTech Connect (OSTI)

    Tang, Lixin; Su, Gui-Jia

    2006-01-01

    The close-loop digital signal processor (DSP) control of an integrated-dual inverter, which is able to drive two permanent magnet (PM) motors independently, is presented and evaluated experimentally. By utilizing the neutral point of the main traction motor, only two inverter poles are needed for the two-phase auxiliary motor. The modified field-oriented control scheme for this integrated inverter was introduced and employed in real-time control. The experimental results show the inverter is able to control two drives independently. An integrated, component count reduced drive is achieved.

  19. Maximizing the throughput of large ad hoc wireless networks

    E-Print Network [OSTI]

    Hua, Y; Huang, Y; Garcia-Luna-Aceves, J J

    2006-01-01

    network consists of wireless routers that are highly coop-point for every m wireless routers in a 2-D This capacitylinks are used for wireless routers). tion rates of a small

  20. Insolation integrator

    DOE Patents [OSTI]

    Dougherty, John J. (Norristown, PA); Rudge, George T. (Lansdale, PA)

    1980-01-01

    An electric signal representative of the rate of insolation is integrated to determine if it is adequate for operation of a solar energy collection system.