National Library of Energy BETA

Sample records for insight inforum interindustry

  1. Modelling Inter-Industry Material Flows

    E-Print Network [OSTI]

    CIEEDAC Modelling Inter-Industry Material Flows: A review of methodologies For Natural Resources Canada By Maggie Tisdale CIEEDAC Energy and Materials Research Group School of Resource and Environmental .................................................................................................. 2 2.2. INDIRECT EFFECTS

  2. Inter-Industry Diffusion of Technology That Results

    E-Print Network [OSTI]

    April 2003 Inter-Industry Diffusion of Technology That Results From ATP Projects ADVANCED TECHNOLOGY PROGRAMADVANCED TECHNOLOGY PROGRAM NIST GCR 03-848 National Institute of Standards and Technology Funding Joel Popkin #12;NIST GCR 03-848 Inter-Industry Diffusion of Technology That Results From ATP

  3. Information Studies & Museum Studies Selected Inforum Resources

    E-Print Network [OSTI]

    Toronto, University of

    . Haycock, K. & Sheldon, B. E. (Eds.). (2008). The portable MLIS: Insight from the experts. Westport, CT

  4. The Inforum LIFT Model

    Gasoline and Diesel Fuel Update (EIA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustments (Billion Cubic Feet) Wyoming963 1.969 1.979 1.988Prices,Flight Paths for Biojet FuelInformation

  5. Update on INSIGHTS Development

    SciTech Connect (OSTI)

    Not Listed; Eric Burgett

    2011-09-01

    INSIGHTS is a transformational separate effects testing capability to perform in situ irradiation studies and characterization of the microscale behavior of nuclear fuel materials under a wide variety of in-pile conditions. Separate effects testing including growth, irradiation, and monitoring of these materials, and encompasses the full science based approach for fuels development from the nanoscale to the mesoscale behavior of the sample material and other defects driven by the modeling and simulation efforts of INL.

  6. An Interindustry Model of El Paso and Hudspeth Counties, Texas 

    E-Print Network [OSTI]

    Coffman, W. S.; Beattie, B. R.; Jones, L. L.; Adams, J. W.

    1976-01-01

    Model of El Paso and Hudspeth Counties, Texas W.S. Coffman B.R. Beattie L.L. Jones J.W. Adams Texas Water Resources Institute Texas A&M University ...

  7. Consumer Energy Use Insights 

    E-Print Network [OSTI]

    McCracken, B.

    2013-01-01

    for Commercialization Pecan Street Research Institute Data driven insights from the nation’s deepest ever customer energy research ESL-KT-13-12-23 CATEE 2013: Clean Air Through Energy Efficiency Conference, San Antonio, Texas Dec. 16-18 5:15 pm! ! ! March 9, 2011! 31...Types of behaviors! to impact Report experiences to others ESL-KT-13-12-23 CATEE 2013: Clean Air Through Energy Efficiency Conference, San Antonio, Texas Dec. 16-18 Correlations and findings Compared to green built homes ESL-KT-13-12-23 CATEE 2013: Clean Air Through...

  8. Modeling for Insights

    SciTech Connect (OSTI)

    Jacob J. Jacobson; Gretchen Matthern

    2007-04-01

    System Dynamics is a computer-aided approach to evaluating the interrelationships of different components and activities within complex systems. Recently, System Dynamics models have been developed in areas such as policy design, biological and medical modeling, energy and the environmental analysis, and in various other areas in the natural and social sciences. The real power of System Dynamic modeling is gaining insights into total system behavior as time, and system parameters are adjusted and the effects are visualized in real time. System Dynamic models allow decision makers and stakeholders to explore long-term behavior and performance of complex systems, especially in the context of dynamic processes and changing scenarios without having to wait decades to obtain field data or risk failure if a poor management or design approach is used. The Idaho National Laboratory recently has been developing a System Dynamic model of the US Nuclear Fuel Cycle. The model is intended to be used to identify and understand interactions throughout the entire nuclear fuel cycle and suggest sustainable development strategies. This paper describes the basic framework of the current model and presents examples of useful insights gained from the model thus far with respect to sustainable development of nuclear power.

  9. Insights on STEM Careers

    SciTech Connect (OSTI)

    Wendelberger, Joanne Roth

    2014-11-05

    This presentation will provide career advice for individuals seeking to go beyond just having a job to building a successful career in the areas of Science, Technology, Engineering, and Mathematics. Careful planning can be used to turn a job into a springboard for professional advancement and personal satisfaction. Topics to be addressed include setting priorities, understanding career ladders, making tough choices, overcoming stereotypes and assumptions by others, networking, developing a professional identify, and balancing a career with family and other personal responsibilities. Insights on the transition from individual technical work to leadership will also be provided. The author will draw upon experiences gained in academic, industrial, and government laboratory settings, as well as extensive professional service and community involvement.

  10. Hyperons: Insights into baryon structures

    SciTech Connect (OSTI)

    Lach, J.

    1991-08-01

    The baryon octet is composed mainly of hyperons. Modern high energy hyperon beams provide a tool for the study of hyperon static properties and interactions. Experiments with these beams have provided new insights into hyperon rare decays, magnetic moments, and interactions. These experiments provide us with insights into the strong, weak, and electromagnetic structure of the baryons. 65 refs., 45 figs., 5 tabs.

  11. ENVIRONMENTAL AND PHYSIOLOGICAL INSIGHTS FROM

    E-Print Network [OSTI]

    Carbone, Alessandra

    CHAPTER 1 ENVIRONMENTAL AND PHYSIOLOGICAL INSIGHTS FROM MICROBIAL GENOME SEQUENCES Alessandra. Wepresentsomerecentresultsofourgroupon the statistical analysis of microbial genomes involving the formalization of microbial spaces from genome sequences by means of a purely statistical analysis and an appropriate design of algorithms

  12. Insight Gained from Simplified Dynamic Analysis

    Broader source: Energy.gov [DOE]

    Insight Gained from Simplified Dynamic Analysis ... or Everything Old is New Again October 21, 2014 Greg Mertz Consultant

  13. Crystal Structures of Phosphite Dehydrogenase Provide Insights...

    Office of Scientific and Technical Information (OSTI)

    Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration Citation Details In-Document Search Title: Crystal Structures of Phosphite...

  14. Insights from UT Austin Energy Poll

    Broader source: Energy.gov [DOE]

    Insights from UT Austin Energy Poll on U.S. Consumer Attitudes, July 24, 2013, Sheril Kirshenbaum, director of The Energy Poll.

  15. IBM Internet Security Systems Threat Insight Monthly

    E-Print Network [OSTI]

    of cryptography as it relates to the computer security industry. We will look at some of the underlying technologyIBM Internet Security Systems X-Force ® Threat Insight Monthly www.iss.netwww.iss.net September . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Contents www.iss.netwww.iss.net IBM Internet Security Systems X-Force ® Threat Insight Monthly

  16. Functional Insights from Structural Genomics

    SciTech Connect (OSTI)

    Forouhar,F.; Kuzin, A.; Seetharaman, J.; Lee, I.; Zhou, W.; Abashidze, M.; Chen, Y.; Montelione, G.; Tong, L.; et al

    2007-01-01

    Structural genomics efforts have produced structural information, either directly or by modeling, for thousands of proteins over the past few years. While many of these proteins have known functions, a large percentage of them have not been characterized at the functional level. The structural information has provided valuable functional insights on some of these proteins, through careful structural analyses, serendipity, and structure-guided functional screening. Some of the success stories based on structures solved at the Northeast Structural Genomics Consortium (NESG) are reported here. These include a novel methyl salicylate esterase with important role in plant innate immunity, a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel methyltransferase or AdoMet binding protein (A. fulgidus AF{_}0241), an ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B. melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP{_}1951), and a 12-stranded {beta}-barrel with a novel fold (V. parahaemolyticus VPA1032).

  17. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  18. ALS Gives Chevron Scientists New Insights into Corrosion Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Gives Chevron Scientists New Insights into Corrosion Resistance ALS Gives Chevron Scientists New Insights into Corrosion Resistance Print Thursday, 25 July 2013 13:44 In the...

  19. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    Mease, Kenneth D.

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View VisionSM Insight University of California Student Health Insurance Plan (UC SHIP) 2014/15 Your Blue View Vision Insight network Blue View Vision Insight offers you

  20. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    Barrett, Jeffrey A.

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2012/13 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  1. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2013/14 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  2. Virus Evolution: Insights from an Experimental

    E-Print Network [OSTI]

    Elena, Santiago F.

    Virus Evolution: Insights from an Experimental Approach Santiago F. Elena and Rafael Sanju Viruses represent a serious problem faced by human and veterinary medicine and agronomy. New viruses indicates that the evolution of viruses is determined mainly by key features such as their small genomes

  3. Communication as information use: insights from statistical

    E-Print Network [OSTI]

    Stephens, David W.

    3 Communication as information use: insights from statistical decision theory caitlin r. kight Communication Theory: Information and Influence, ed. Ulrich Stegmann. Published by Cambridge University Press focuses on the latter, which forms the basis of animal communication. Animal communication has been

  4. www.vics.org1 2008 Voluntary Interindustry Commerce Solutions (VICS) Association September 27, 2011

    E-Print Network [OSTI]

    Lin, Xiaodong

    . Production is already past its peak in 54 of the 65 largest oil-producing countries. New oil takes more and energy. Oil contributes about 40% of global energy production, but over 95% of all transport fuel. #12 (VICS) Association Time is Up! Production growth will eventually stop and production will peak

  5. A Minnesota Blizzard Provides Insight into Utility-Scale Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A Minnesota Blizzard Provides Insight into Utility-Scale Wind Turbine Wakes A Minnesota Blizzard Provides Insight into Utility-Scale Wind Turbine Wakes September 12, 2014 - 11:22am...

  6. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

  7. The Eyjafjallajkull volcanic system, Iceland: insights from electromagnetic measurements

    E-Print Network [OSTI]

    Jones, Alan G.

    The Eyjafjallajökull volcanic system, Iceland: insights from electromagnetic measurements Journal; Iceland Geosurvey, Vilhjálmsson, Arnar; Iceland Geosurvey, Keywords: Magnetotellurics system, Iceland: insights from1 electromagnetic measurements2 Marion P. Miensopust1,2, , Alan G. Jones1

  8. Insights from Human/Mouse genome comparisons

    SciTech Connect (OSTI)

    Pennacchio, Len A.

    2003-03-30

    Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

  9. Insights from an overview of four PRAs

    SciTech Connect (OSTI)

    Fitzpatrick, R.; Arrieta, L.; Teichmann, T.; Davis, P.

    1986-01-01

    This paper summarizes the findings of an investigation of four probabilistic risk assessments (PRAs), those for Millstone 3, Seabrook, Shoreham, and Oconee 3, performed by Brookhaven National Laboratory (BNL) for the Reliability and Risk Assessment Branch of the US Nuclear Regulatory Commission (NRC). This group of four PRAs was subjected to an overview process with the basic goal of ascertaining what insights might be gained (beyond those already documented within the individual PRAs) by an independent evaluation of the group with respect to nuclear plant safety and vulnerability. Specifically, the objectives of the study were (1) to identify and rank initiators, systems, components, and failure modes from dominant accident sequences according to their contribution to core melt probability and public risk; and (2) to derive from this process plant-specific and generic insights. The effort was not intended to verify the specific details and results of each PRA but rather - having accepted the results - to see what they might mean in a more global context. The NRC had previously sponsored full detailed reviews of each of these PRAs, but only two, those for Millstone 3 and Shoreham, were completed and documented in time to allow their consideration within the study. This paper also presents some comments and insights into the amenability of certain features of these PRAs to this type of overview process.

  10. New insights into HIV-1 vaccine design

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework usesofPublications64 2.251 2.211NewNew exhibitNew insights into HIV-1

  11. Insights from Smart Meters: Identifying Specific Actions, Behaviors...

    Energy Savers [EERE]

    and Characteristics That Drive Savings in Behavior-Based Programs Insights from Smart Meters: Identifying Specific Actions, Behaviors, and Characteristics That Drive...

  12. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  13. Vertebrate Membrane Proteins: Structure, Function, and Insights from Biophysical Approaches

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    Vertebrate Membrane Proteins: Structure, Function, and Insights from Biophysical Approaches DANIEL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 B. Membrane proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 III. Interactions of proteins with membranes

  14. Diesel Engine Oil Technology Insights and Opportunities | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology Insights and Opportunities Perrformance of API CJ-4 diesel engine lubricating oil and emerging lubricant technologiy are examined with respect to protection and fuel...

  15. Polarization Insights for Active Galactic Nuclei

    E-Print Network [OSTI]

    Antonucci, R

    2001-01-01

    Optical spectropolarimetry and broadband polarimetry in other wavebands has been a key to understanding many diverse aspects of AGN. In some cases polarization is due to synchrotron radiation, and in other cases it's due to scattering. Recognition of relativistically beamed optical synchrotron emission by polarization was vital for understanding blazars (BL Lacs and Optically Violently Variable quasars), both physically and geometrically. Radio polarimetry of quiescent AGN is equally important, again for both purposes. Scattering polarization was central to the Unified Model for Seyferts, Radio Galaxies and (high ionization) Ultraluminous Infrared Galaxies. It provides a periscope for viewing AGN from other directions. Finally, if we could understand its message, polarization would also provide major insights regarding the nature of the AGN "Featureless Continuum" and Broad (emission) Line Region. I point out that high ionization ULIRGs have all the exact right properties to be called Quasar 2s. Mid-IR observ...

  16. AVTA: 2010 Honda Insight HEV Testing Results

    Broader source: Energy.gov [DOE]

    The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following reports describe results of testing done on a 2010 Honda Insight hybrid-electric vehicle. Baseline and other data collected at Idaho National Laboratory is in the attached documents. Baseline and battery testing data collected at Argonne National Laboratory is available in summary and CSV form on the Argonne Downloadable Dynometer Database site (http://www.anl.gov/energy-systems/group/downloadable-dynamometer-databas...). Taken together, these reports give an overall view of how this vehicle functions under extensive testing.

  17. Evolution of the Bohemian Massif: Insights from numerical modeling

    E-Print Network [OSTI]

    Cerveny, Vlastislav

    Evolution of the Bohemian Massif: Insights from numerical modeling Petra Maierová Supervisor: Doc of Geophysics Faculty of Mathematics and Physics Charles University in Prague #12;February 4, 2013Evolution Conclusions Outline #12;February 4, 2013Evolution of the Bohemian Massif: Insights from numerical modeling 3

  18. CHAPTER 1 --Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation 1 Expanding Insight into the Asymmetric Palladium-Catalyzed

    E-Print Network [OSTI]

    Stoltz, Brian M.

    CHAPTER 1 -- Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation 1 CHAPTER 1 Expanding Insight into the Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules this motif,1 palladium-catalyzed decarboxylative allylic alkylation2,3 has proven particularly effective and

  19. Polarization Insights for Active Galactic Nuclei

    E-Print Network [OSTI]

    R. R. J. Antonucci

    2001-03-02

    Optical spectropolarimetry and broadband polarimetry in other wavebands has been a key to understanding many diverse aspects of AGN. In some cases polarization is due to synchrotron radiation, and in other cases it's due to scattering. Recognition of relativistically beamed optical synchrotron emission by polarization was vital for understanding blazars (BL Lacs and Optically Violently Variable quasars), both physically and geometrically. Radio polarimetry of quiescent AGN is equally important, again for both purposes. Scattering polarization was central to the Unified Model for Seyferts, Radio Galaxies and (high ionization) Ultraluminous Infrared Galaxies. It provides a periscope for viewing AGN from other directions. Finally, if we could understand its message, polarization would also provide major insights regarding the nature of the AGN "Featureless Continuum" and Broad (emission) Line Region. I point out that high ionization ULIRGs have all the exact right properties to be called Quasar 2s. Mid-IR observations generally don't penetrate to the nucleus, greatly reducing their ability to diagnose the energy source. In particular, LINER ULIRGs aren't necessarily starburst-dominated, as has been claimed.

  20. Worldwide Trends in Energy Use and Efficiency: Key Insights from...

    Open Energy Info (EERE)

    Trends in Energy Use and Efficiency: Key Insights from International Energy Agency (IEA) Indicator Analysis in Support of the Group of Eight (G8) Plan of Action Jump to:...

  1. Genome sequence of the Brown Norway rat yields insights into

    E-Print Network [OSTI]

    Payseur, Bret

    Genome sequence of the Brown Norway rat yields insights into mammalian evolution Rat Genome Norway (BN) rat strain. The sequence represents a high-quality `draft' covering over 90% of the genome

  2. Building America Whole-House Solutions for New Homes: Insight...

    Broader source: Energy.gov (indexed) [DOE]

    Insight Homes, who worked with the Building America research partner IBACOS to design HERS-49 homes with high-efficiency HVAC, ducts in insulated crawl spaces, raised heel trusses,...

  3. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

  4. Remarkable insights into the paleoecology of the Avalonian Ediacaran macrobiota

    E-Print Network [OSTI]

    Liu, Alexander G.; Kenchington, Charlotte G.; Mitchell, Emily G.

    2014-12-04

    is their relevance to the early evolutionary history of the Kingdom Animalia. In recent years, new data and discoveries have revealed insights into Ediacaran paleobiology, taxonomic relationships, paleoecology and taphonomy, significantly refining our understanding...

  5. Decision insight into stakeholder conflict for ERN.

    SciTech Connect (OSTI)

    Siirola, John; Tidwell, Vincent Carroll; Benz, Zachary O.; Stansbury, Melanie; Richards, Elizabeth H.; Turnley, Jessica Glicken; Warrender, Christina E.; Morrow, James Dan

    2012-02-01

    Participatory modeling has become an important tool in facilitating resource decision making and dispute resolution. Approaches to modeling that are commonly used in this context often do not adequately account for important human factors. Current techniques provide insights into how certain human activities and variables affect resource outcomes; however, they do not directly simulate the complex variables that shape how, why, and under what conditions different human agents behave in ways that affect resources and human interactions related to them. Current approaches also do not adequately reveal how the effects of individual decisions scale up to have systemic level effects in complex resource systems. This lack of integration prevents the development of more robust models to support decision making and dispute resolution processes. Development of integrated tools is further hampered by the fact that collection of primary data for decision-making modeling is costly and time consuming. This project seeks to develop a new approach to resource modeling that incorporates both technical and behavioral modeling techniques into a single decision-making architecture. The modeling platform is enhanced by use of traditional and advanced processes and tools for expedited data capture. Specific objectives of the project are: (1) Develop a proof of concept for a new technical approach to resource modeling that combines the computational techniques of system dynamics and agent based modeling, (2) Develop an iterative, participatory modeling process supported with traditional and advance data capture techniques that may be utilized to facilitate decision making, dispute resolution, and collaborative learning processes, and (3) Examine potential applications of this technology and process. The development of this decision support architecture included both the engineering of the technology and the development of a participatory method to build and apply the technology. Stakeholder interaction with the model and associated data capture was facilitated through two very different modes of engagement, one a standard interface involving radio buttons, slider bars, graphs and plots, while the other utilized an immersive serious gaming interface. The decision support architecture developed through this project was piloted in the Middle Rio Grande Basin to examine how these tools might be utilized to promote enhanced understanding and decision-making in the context of complex water resource management issues. Potential applications of this architecture and its capacity to lead to enhanced understanding and decision-making was assessed through qualitative interviews with study participants who represented key stakeholders in the basin.

  6. Technical Insights for Saltstone PA Maintenance

    SciTech Connect (OSTI)

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and compatibility with existing CBP expertise and already-planned activities. Based on these criteria, the five original topics were down-selected to two: external sulfate attack and mechanistic geochemical prediction. For each of the selected topics, the CBP communicated with the PA analysts and subject matter experts at Savannah River to acquire input data specific to the Saltstone facility and related laboratory experiments. Simulations and analyses were performed for both topics using STADIUM (SIMCO 2008), LeachXS/ORCHESTRA (ECN 2007, Meeussen 2003), and other software tools. These supplemental CBP analyses produced valuable technical insights that can be used to strengthen the Saltstone PA using the ongoing PA maintenance process. This report in part summarizes key information gleaned from more comprehensive documents prepared by Sarkar et al. (2010), Samson (2010), and Sarkar (2010).

  7. Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp.

    E-Print Network [OSTI]

    2011-01-01

    Complete Genome Sequences Offer Insight into Host and TissueComplete Genome Sequences Offer Insight into Host and Tissue

  8. Uncertainty and Predictability in Geophysics: Chaos and Multifractal Insights

    E-Print Network [OSTI]

    Lovejoy, Shaun

    Uncertainty and Predictability in Geophysics: Chaos and Multifractal Insights Daniel Schertzer Department, McGill University, Montreal, Canada Uncertainty and error growth are crosscutting geophysical extremes. The focus is now on time-space geophysical scaling behavior: their multifractality. It is found

  9. Insights into the molecular architecture of the 26S proteasome

    E-Print Network [OSTI]

    Sali, Andrej

    Insights into the molecular architecture of the 26S proteasome Stephan Nickella , Florian Becka module in the ``base'' part of the regulatory complex that can vary in its position and orientation with exquisite specificity. The key stratagem is self-compartmentalization: the active sites of the proteolytic

  10. Theoretical insights into multibandgap hybrid perovskites for photovoltaic applications

    E-Print Network [OSTI]

    Theoretical insights into multibandgap hybrid perovskites for photovoltaic applications J. Even theoretically the crystalline phases of one of the hybrids relevant for photovoltaic applications, namely CH3NH3, evidencing inversion of band edge states. Keywords: Photovoltaic, Hybrid perovskite, density functional

  11. Analysing the Carbon Footprint of Food Insights for Consumer Communication

    E-Print Network [OSTI]

    Analysing the Carbon Footprint of Food Insights for Consumer Communication Elin Röös Faculty-91-576-7851-5 © 2013 Elin Röös, Uppsala Print: SLU Service/Repro, Uppsala 2013 #12;Analysing the Carbon Footprint the results in perspective. Keywords: carbon footprint, food, uncertainty, pollution swapping, consumer

  12. Wind Extremes and Scales: Multifractal Insights and Empirical Evidence

    E-Print Network [OSTI]

    Lovejoy, Shaun

    17 Wind Extremes and Scales: Multifractal Insights and Empirical Evidence I. Tchiguirinskaia, D. Schertzer, S. Lovejoy, J.M. Veysseire Summary. An accurate assessment of wind extremes at various space-time scales (e.g. gusts, tempests, etc.) is of prime importance for a safe and efficient wind energy

  13. How Does the Mind Work? Insights from Biology Gary Marcus

    E-Print Network [OSTI]

    Marcus, Gary F.

    How Does the Mind Work? Insights from Biology Gary Marcus Department of Psychology, New York Abstract Cognitive scientists must understand not just what the mind does, but how it does what it does architecture One mission of cognitive science is to figure out what the mind does: What is the capacity

  14. Nuclear magnetic resonance offers new insights into Pu 239

    E-Print Network [OSTI]

    - 1 - Nuclear magnetic resonance offers new insights into Pu 239 May 29, 2012 Nuclear magnetic signal of plutonium 239's unique nuclear magnetic resonance signature has been detected by scientists on the subject, "Observation of 239 Pu Nuclear Magnetic Resonance," was published in the May 18 issue of Science

  15. Insight Vol 47 No 5 May 2005 269 Introduction

    E-Print Network [OSTI]

    Clapham, Lynann

    of the pipeline, results in the creation of residual stress regions. When clustering of the corrosion defectsInsight Vol 47 No 5 May 2005 269 Introduction Structural integrity and reliability of pipelines geometry and frequency of occurrence, pipeline operators have to decide on the time intervals for periodic

  16. Physiological Insights Towards Improving Fish Culture L. CURRY WOODS III*

    E-Print Network [OSTI]

    Hamza, Iqbal

    Physiological Insights Towards Improving Fish Culture L. CURRY WOODS III* Department of Animal, and American Fisheries Society (AFS) Fish Culture Section, was held February 26 through March 2, 2007, in San Antonio, Texas. At this meeting, the AFS Fish Culture and Fish Physiol- ogy Sections co

  17. Proportional Fair Scheduling: Analytical Insight under Rayleigh Fading Environment

    E-Print Network [OSTI]

    Leung, Kin K.

    Proportional Fair Scheduling: Analytical Insight under Rayleigh Fading Environment Erwu Liu and Kin to the constraint of proportional fairness amongst users. The proportional fair scheduling (PFS) algorithm, but also it applies to various kinds of network scenarios. Keywords-proportional fair scheduling, gaussian

  18. Selecting Solar. Insights into Residential Photovoltaic (PV) Quote Variation

    SciTech Connect (OSTI)

    Davidson, Carolyn; Margolis, Robert

    2015-10-01

    This analysis leverages available data from EnergySage, an online solar marketplace, to offer the first data-driven characterization of quote variation faced by prospective PV customers, lending early insight into the decisions customers face once they have initial buy-in.

  19. Energy and Water Interactions: Insights from Mathematical Models

    E-Print Network [OSTI]

    Keller, Arturo A.

    1 Energy and Water Interactions: Insights from Mathematical Models Jay R. Lund Kaveh Madani Civil;2 Outline 1. Informational - Energy in water production - Water in energy production 2. Philosophical;3 Energy in Water Production/Use 1. Pumping ­ energy use 2. Maintenance, chemicals - Pumping and treatment

  20. Hydraulic design of leaves: insights from rehydration kinetics

    E-Print Network [OSTI]

    Holbrook, N. Michele

    Hydraulic design of leaves: insights from rehydration kinetics MACIEJ A. ZWIENIECKI1 , TIMOTHY J design in 10 species based on their rehydration kinetics. In all cases, a biphasic response described extension; tran- spiration stream; hydraulic compartmentalization. INTRODUCTION Leaves of terrestrial plants

  1. Groundwater and global hydrological change current challenges and new insight

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Groundwater and global hydrological change ­ current challenges and new insight R. TAYLOR1 , L Groundwater Resources Assessment Centre, Utrecht, The Netherlands 11 Federal Institute for Geosciences, groundwater plays a critical role in enabling communities to adapt to freshwater shortages derived from low

  2. New insights from in-situ electron microscopy into capacity loss...

    Office of Scientific and Technical Information (OSTI)

    New insights from in-situ electron microscopy into capacity loss mechanisms in Li-ion batteries with Al anodes. Citation Details In-Document Search Title: New insights from in-situ...

  3. Climate Insights 101 Questions and Discussion Points: Module 1, Lesson 4: An Introduction to Climate Modelling

    E-Print Network [OSTI]

    Pedersen, Tom

    Climate Insights 101 Questions and Discussion Points: Module 1, Lesson 4: An Introduction to Climate Modelling 1 Climate Insights 101 Questions and Discussion Points Module 1, Lesson 4: An Introduction to Climate Modelling Available at http://pics.uvic.ca/education/climate-insights-101 Updated May

  4. Model year 2010 Honda insight level-1 testing report.

    SciTech Connect (OSTI)

    Rask, E.; Bocci, D.; Duoba, M.; Lohse-Busch, H.

    2011-03-22

    As a part of the US Department of Energy's Advanced Vehicle Testing Activity (AVTA), a model year 2010 Honda Insight was procured by eTec (Phoenix, AZ) and sent to ANL's Advanced Powertrain Research Facility for the purposes of vehicle-level testing in support of the Advanced Vehicle Testing Activity (AVTA). Data was acquired during testing using non-intrusive sensors, vehicle network information, and facilities equipment (emissions and dynamometer data). Standard drive cycles, performance cycles, steady-state cycles and A/C usage cycles were tested. Much of this data is openly available for download in ANL's Downloadable Dynamometer Database (D3). The major results are shown here in this report. Given the preliminary nature of this assessment, the majority of the testing was done over standard regulatory cycles and seeks to obtain a general overview of how the vehicle performs. These cycles include the US FTP cycle (Urban) and Highway Fuel Economy Test cycle as well as the US06, a more aggressive supplemental regulatory cycle. Data collection for this testing was kept at a fairly high level and includes emissions and fuel measurements from an exhaust emissions bench, high-voltage and accessory current and voltage from a DC power analyzer, and CAN bus data such as engine speed, engine load, and electric machine operation when available. The following sections will seek to explain some of the basic operating characteristics of the MY2010 Insight and provide insight into unique features of its operation and design.

  5. Theatre Circle INSIGHTS Special Edition -Fall 2011Theatre Circle INSIGHTS Special Edition -Fall 2011 Indiana University Department of Theatre and DramaIndiana University Department of Theatre and Drama

    E-Print Network [OSTI]

    Indiana University

    Theatre Circle INSIGHTS Special Edition - Fall 2011Theatre Circle INSIGHTS Special Edition - Fall and the local economy. We created a High School Intern program that

  6. Inforum/ Information Services, Faculty of Information http://current.ischool.utoronto.ca/services/inforum-is February 2015 Albagli, S., & Maciel, M.L. (Eds.). (2010). Information, power and politics: Technological and institutional

    E-Print Network [OSTI]

    Toronto, University of

    2010-01-01

    of indigenous ideas, signs and symbols. Drawing on a combination of theory and case studies, Brown shows how Maciel, this resource assesses the various ways in which information and communication technologies, or ICTs, both provide users with the tools to overcome social and economic inequalities, as well

  7. Insights into C4 metabolism from comparative deep sequencing

    E-Print Network [OSTI]

    Burgess, Steven J.; Hibberd, Julian M.

    2015-06-05

    subtypes: insights from comparative transcriptome analysis of NAD-ME, NADP-219 ME, and PEP-CK C4 species. J. Exp. Bot. 2014, 65:3579–93. 220 12. Brautigam A, Kajala K, Wullenweber J, Sommer M, Gagneul D, Weber KL, Carr KM, Gowik U, Mass J, 221 Lercher... 11 16. Wang Y, Bräutigam A, Weber APM, Zhu X-G: Three distinct biochemical subtypes of C4 235 photosynthesis? A modelling analysis. J. Exp. Bot. 2014, 65:3567–78. 236 17. Sommer M, Bräutigam A, Weber APM: The dicotyledonous NAD malic enzyme C4...

  8. Qualification for PowerInsight accuracy of power measurements.

    SciTech Connect (OSTI)

    DeBonis, David; Laros, James H.,; Pedretti, Kevin Thomas Tauke

    2013-11-01

    Accuracy of component based power measuring devices forms a necessary basis for research in the area of power-e cient and power-aware computing. The accuracy of these devices must be quanti ed within a reasonable tolerance. This study focuses on PowerInsight, an out- of-band embedded measuring device which takes readings of power rails on compute nodes within a HPC system in realtime. We quantify how well the device performs in comparison to a digital oscilloscope as well as PowerMon2. We show that the accuracy is within a 6% deviation on measurements under reasonable load.

  9. Selecting Solar: Insights into Residential Photovoltaic (PV) Quote Variation

    SciTech Connect (OSTI)

    Davidson, Carolyn; Margolis, Robert

    2015-10-01

    Before investing in a system, a prospective PV customer must not only have initial concept 'buy in,' but also be able to evaluate the tradeoffs associated with different system parameters. Prospective customers might need to evaluate disparate costs for each system attribute by comparing multiple bids. The difficulty of making such an evaluation with limited information can create a cognitive barrier to proceeding with the investment. This analysis leverages recently available data from EnergySage, an online solar marketplace, to offer the first data-driven characterization of quote variation faced by prospective PV customers, lending early insight into the decisions customers face once they have initial buy-in.

  10. Structural Insights into FeMo Cofactor Biosynthesis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3EnergyParameter SpecificationsInsights into

  11. Scientists gain insight into origin of tungsten ditelluride's

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-ThroughputUpcomingmagnetoresistance | Argonne National Laboratory gain insight

  12. Voices of Experience: Insights on Smart Grid Customer Engagement (July

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutoryinEnableVisualization & Controls ProgramInsights

  13. Los Alamos offers new insights into radiation damage evolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse BergkampCentermillion to local Unitedto STEMLANLTeamLos AlamosNew insights

  14. New insights into regulating the gut's microbial community | Argonne

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework usesofPublications64 2.251 2.211NewNew exhibitNew insights into

  15. Physics of Reliability: Evaluating Design Insights for Component Technologies in Solar (PREDICTS) Funding Opportunity

    Broader source: Energy.gov [DOE]

    The Physics of Reliability: Evaluating Design Insights for Component Technologies in Solar (PREDICTS) program supports projects that evaluate the degradation and failure mechanisms of concentrating...

  16. Paleoecology in an Era of Climate Change: How the Past Can Provide Insights into the Future

    E-Print Network [OSTI]

    Smith, Felisa A.

    Chapter 6 Paleoecology in an Era of Climate Change: How the Past Can Provide Insights · Conservation · Paleoecology · Vulnerability · Adaptation · Community dynamics · Neotoma · Historic ecology 6

  17. Research news sidebar: Farm Smart offers hands-on experience, insight into where food comes from

    E-Print Network [OSTI]

    Meadows, Robin

    2012-01-01

    Alan Robertson, Caywood offers more than 150 daylongJanuary and February, Caywood offers a similar outreachNancy Caywood Farm Smart offers hands-on experience, insight

  18. Structural and mechanistic insights into Mcm2-7 double-hexamer...

    Office of Scientific and Technical Information (OSTI)

    and mechanistic insights into Mcm2-7 double-hexamer assembly and function Sun, Jingchuan Brookhaven National Laboratory (BNL), Upton, NY (United States); Li, Huilin Brookhaven...

  19. Nonclassicality Phase-Space Functions: More Insight with Fewer Detectors

    E-Print Network [OSTI]

    A. Luis; J. Sperling; W. Vogel

    2015-03-17

    Systems of on-off detectors are well established for measuring radiation fields in the regime of small photon numbers. We propose to combine these detector systems with unbalanced homodyning with a weak local oscillator. This approach yields phase-space functions, which represent the click counterpart of the s parametrized quasiprobabilities of standard photoelectric detection theory. This introduced class of distributions can be directly sampled from the measured click counting statistics. Therefore, our technique visualizes nonclassical effects without further data processing. Surprisingly, a small number of on-off diodes can yield more insight than perfect photon number resolution. Quantum signatures in the particle and wave domain of the quantized radiation field, as shown by photon number and squeezed states, respectively, will be uncovered in terms of negativities of the sampled phase-space functions. Application in the vast fields of quantum optics and quantum technology will benefit from our efficient nonclassicality characterization approach.

  20. "Omics of the mammalian gut new insights into function

    SciTech Connect (OSTI)

    Lamendella, Regina; Verberkmoes, Nathan C; Jansson, Janet

    2012-01-01

    To understand the role of gut microbes in host health, it is imperative to probe their genetic potential, expression, and ecological status. The current high-throughput sequencing revolution, in addition to advances in mass spectrometry-based proteomics, have recently enabled deep access to these complex environments, and are revealing important insights into the roles of the gastrointestinal (GI) microbiota in host physiology and health. This review discusses examples of how the integration of cutting-edge meta-omics technologies are providing new knowledge about the relationships between host health status in mammals and the microbes inhabiting the GI tract. In addition, we address some promises that these techniques hold for future therapeutic and diagnostic applications.

  1. NREL Highlights SCIENCE Research provides insight for exploring use of Earth-

    E-Print Network [OSTI]

    NREL Highlights SCIENCE Research provides insight for exploring use of Earth- abundant quaternary, it is critical to find new material that is Earth abundant and easily manufactured. Previous experimental studies This research provides insight for exploring use of Earth-abundant quaternary semiconductors for large

  2. Global pattern of earthquakes and seismic energy distributions: Insights for the mechanisms of plate tectonics

    E-Print Network [OSTI]

    Stuttgart, Universität

    ÔØ Å ÒÙ× Ö ÔØ Global pattern of earthquakes and seismic energy distributions: Insights energy distributions: insights for the mechanisms of plate tectonics P. Vargaa , F. Krummb , F. Riguzzic In this paper, we analyse the distributions of number of events (N) and seismic energy (E) on the Earth

  3. Making Sustainable Energy Choices: Insights on the Energy/Water/Land Nexus

    SciTech Connect (OSTI)

    Not Available

    2014-10-01

    This periodic publication summarizes insights from the body of NREL analysis work. In this issue of Analysis Insights, we examine the implications of our energy choices on water, land use, climate, developmental goals, and other factors. Collectively, NREL's work helps policymakers and investors understand and evaluate energy choices within the complex web of connections, or nexus, between energy, water, and land.

  4. Some insight on why Bam (Iran) was destroyed by an earthquake of relatively moderate size

    E-Print Network [OSTI]

    Hatzfeld, Denis

    Some insight on why Bam (Iran) was destroyed by an earthquake of relatively moderate size Michel March 2006; accepted 29 March 2006; published 13 May 2006. [1] The Bam (Iran) earthquake of 2003. Hatzfeld, J. A. Jackson, and E. Haghshenas (2006), Some insight on why Bam (Iran) was destroyed

  5. Theatre Circle INSIGHTS Special Edition -Fall 2010Theatre Circle INSIGHTS Special Edition -Fall 2010 Indiana University Department of Theatre and DramaIndiana University Department of Theatre and Drama

    E-Print Network [OSTI]

    Indiana University

    Theatre Circle INSIGHTS Special Edition - Fall 2010Theatre Circle INSIGHTS Special Edition - Fall: the activities of alumni; recent visitors to the department; the return of the M.F.A. playwriting program

  6. Delivering Insight The History of the Accelerated Strategic Computing Initiative

    SciTech Connect (OSTI)

    Larzelere II, A R

    2007-01-03

    The history of the Accelerated Strategic Computing Initiative (ASCI) tells of the development of computational simulation into a third fundamental piece of the scientific method, on a par with theory and experiment. ASCI did not invent the idea, nor was it alone in bringing it to fruition. But ASCI provided the wherewithal - hardware, software, environment, funding, and, most of all, the urgency - that made it happen. On October 1, 2005, the Initiative completed its tenth year of funding. The advances made by ASCI over its first decade are truly incredible. Lawrence Livermore, Los Alamos, and Sandia National Laboratories, along with leadership provided by the Department of Energy's Defense Programs Headquarters, fundamentally changed computational simulation and how it is used to enable scientific insight. To do this, astounding advances were made in simulation applications, computing platforms, and user environments. ASCI dramatically changed existing - and forged new - relationships, both among the Laboratories and with outside partners. By its tenth anniversary, despite daunting challenges, ASCI had accomplished all of the major goals set at its beginning. The history of ASCI is about the vision, leadership, endurance, and partnerships that made these advances possible.

  7. Molecular insight into conformational transmission of human P-glycoprotein

    SciTech Connect (OSTI)

    Chang, Shan-Yan [Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China)] [Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Liu, Fu-Feng, E-mail: fufengliu@tju.edu.cn, E-mail: ysun@tju.edu.cn; Dong, Xiao-Yan; Sun, Yan, E-mail: fufengliu@tju.edu.cn, E-mail: ysun@tju.edu.cn [Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China) [Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China)

    2013-12-14

    P-glycoprotein (P-gp), a kind of ATP-binding cassette transporter, can export candidates through a channel at the two transmembrane domains (TMDs) across the cell membranes using the energy released from ATP hydrolysis at the two nucleotide-binding domains (NBDs). Considerable evidence has indicated that human P-gp undergoes large-scale conformational changes to export a wide variety of anti-cancer drugs out of the cancer cells. However, molecular mechanism of the conformational transmission of human P-gp from the NBDs to the TMDs is still unclear. Herein, targeted molecular dynamics simulations were performed to explore the atomic detail of the conformational transmission of human P-gp. It is confirmed that the conformational transition from the inward- to outward-facing is initiated by the movement of the NBDs. It is found that the two NBDs move both on the two directions (x and y). The movement on the x direction leads to the closure of the NBDs, while the movement on the y direction adjusts the conformations of the NBDs to form the correct ATP binding pockets. Six key segments (KSs) protruding from the TMDs to interact with the NBDs are identified. The relative movement of the KSs along the y axis driven by the NBDs can be transmitted through ?-helices to the rest of the TMDs, rendering the TMDs to open towards periplasm in the outward-facing conformation. Twenty eight key residue pairs are identified to participate in the interaction network that contributes to the conformational transmission from the NBDs to the TMDs of human P-gp. In addition, 9 key residues in each NBD are also identified. The studies have thus provided clear insight into the conformational transmission from the NBDs to the TMDs in human P-gp.

  8. Direct observations of DNA provides new insights into how genetic material is copied and repaired News-Medical.Net

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Direct observations of DNA provides new insights into how genetic material is copied and repaired News-Medical.Net · Home Page Direct observations of DNA provides new insights into how genetic material to a Friend Direct observations of DNA are giving new insights into how genetic material is copied

  9. Insights into Industrial Energy Auditing from the EADC Program: An Academic Perspective 

    E-Print Network [OSTI]

    Muller, M. R.; Polomski, P. P.

    1993-01-01

    Energy auditing as a tool for energy conservation is discussed using insights gained from data gathered from the DOE EADC program over a ten year period. Details about the contents of the database, procedures for it access and sample "products...

  10. New insights from in-situ electron microscopy into capacity loss...

    Office of Scientific and Technical Information (OSTI)

    in-situ electron microscopy into capacity loss mechanisms in all-solid-state Li-ion batteries with Al anodes. Citation Details In-Document Search Title: New insights from in-situ...

  11. Resolving arthropod relationships: Present and future insights from evo-devo studies

    E-Print Network [OSTI]

    Popadic', Aleksandar

    Resolving arthropod relationships: Present and future insights from evo-devo studies STEVEN HRYCAJ-evaluation of traditionally assigned morphological homologies. The field of evolutionary developmental biology (evo- devo) has

  12. N2O and CH4 variations during the last glacial epoch: Insight into global processes

    E-Print Network [OSTI]

    Chappellaz, Jérôme

    provide important insight into the former composition of the atmosphere, its natural variations; accepted 12 December 2003; published 30 January 2004. [1] Greenhouse gas measurements along polar ice cores reconstructed for Greenland. INDEX TERMS: 0325 Atmospheric Composition and Structure: Evolution

  13. Insights into fold growth using fold-related joint patterns and mechanical stratigraphy

    E-Print Network [OSTI]

    Savage, Heather M.

    Insights into fold growth using fold-related joint patterns and mechanical stratigraphy Heather M Available online 17 September 2010 Keywords: Sheep Mountain Anticline Joint pattern Mechanical stratigraphy, we integrate mechanical stratigraphy with joint pattern analysis to determine relative timing

  14. Global pattern of earthquakes and seismic energy distributions: Insights for the mechanisms of plate tectonics

    E-Print Network [OSTI]

    Global pattern of earthquakes and seismic energy distributions: Insights for the mechanisms Institut, Universität Stuttgart, Germany c Istituto Nazionale di Geofisica e Vulcanologia, Roma, Italy d October 2011 Keywords: Global seismicity Declustered catalogue Earthquake energy distribution Plate

  15. Complexity within the Air Force acquisition system gaining insight from a theory of collapse

    E-Print Network [OSTI]

    Marticello, Daniel Nicholas, Jr

    2012-01-01

    Joseph Tainter's theory of societal collapse is applied in an examination of the U.S. Air Force's aircraft acquisition system in order to gain insight into the enterprise's lagging performance. Theories of collapse at both ...

  16. Insights from twenty years of bacterial genome sequencing

    SciTech Connect (OSTI)

    Land, Miriam L; Hauser, Loren John; Jun, Se Ran; Nookaew, Intawat; Leuze, Michael Rex; Ahn, Tae-Hyuk; Karpinets, Tatiana V; Lund, Ole; Kora, Guruprasad H; Wassenaar, Trudy; Poudel, Suresh; Ussery, David W

    2015-01-01

    Since the first two complete bacterial genome sequences were published in 1995, the science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is possible to completely sequence a bacterial genome in a few hours and identify some types of methylation sites along the genome as well. Sequencing of bacterial genome sequences is now a standard procedure, and the information from tens of thousands of bacterial genomes has had a major impact on our views of the bacterial world. In this review, we explore a series of questions to highlight some insights that comparative genomics has produced. To date, there are genome sequences available from 50 different bacterial phyla and 11 different archaeal phyla. However, the distribution is quite skewed towards a few phyla that contain model organisms. But the breadth is continuing to improve, with projects dedicated to filling in less characterized taxonomic groups. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system provides bacteria with immunity against viruses, which outnumber bacteria by tenfold. How fast can we go? Second-generation sequencing has produced a large number of draft genomes (close to 90 % of bacterial genomes in GenBank are currently not complete); third-generation sequencing can potentially produce a finished genome in a few hours, and at the same time provide methlylation sites along the entire chromosome. The diversity of bacterial communities is extensive as is evident from the genome sequences available from 50 different bacterial phyla and 11 different archaeal phyla. Genome sequencing can help in classifying an organism, and in the case where multiple genomes of the same species are available, it is possible to calculate the pan- and core genomes; comparison of more than 2000 Escherichia coli genomes finds an E. coli core genome of about 3100 gene families and a total of about 89,000 different gene families. Why do we care about bacterial genome sequencing? There are many practical applications, such as genome-scale metabolic modeling, biosurveillance, bioforensics, and infectious disease epidemiology. In the near future, high-throughput sequencing of patient metagenomic samples could revolutionize medicine in terms of speed and accuracy of finding pathogens and knowing how to treat them.

  17. Insight in the Brain: The Cognitive and Neural Bases of Eureka Moments

    SciTech Connect (OSTI)

    Beeman, Mark

    2013-04-03

    Where do new ideas come from? Although all new ideas build on old, this can happen in different ways. Some new ideas, or solutions to old problems, are achieved through methodical, analytical processing. Other new ideas come about in a sudden burst of insight, often based on or generating a restructured view of the problem itself. Behavioral, brain imaging, and eye-tracking results all reveal distinct cortical networks contributing to insight solving, as contrasted with analytic solving. Consistently, the way in which people solve problems appears to relate to the way they engage attention and cognitive control: across time, across moods, and across individuals. Insight is favored when people can disengage from strong stimuli and associations - figuratively and literally looking "outside the box" of the problem to suddenly solve with a new idea.

  18. U.S. Solar Market Insight®: 2014 Year In Review (Executive Summary)

    Broader source: Energy.gov [DOE]

    U.S. Solar Market Insight is a quarterly publication of the Solar Energy Industries Association (SEIA)® and GTM Research. Each quarter, they survey nearly 200 installers, manufacturers, utilities, and state agencies to collect granular data on photovoltaic (PV) and concentrating solar. These data provide the backbone of the Solar Market Insight report, in which they identify and analyze trends in U.S. solar demand, manufacturing, and pricing by state and market segment. This analysis also forecasts demand over the next five years. As the U.S. solar market expands, it is the hope that Solar Market Insight will provide an invaluable decision-making tool for installers, suppliers, investors, policymakers, and advocates alike.

  19. Theatre Circle INSIGHTS Special Edition -Fall 2013Theatre Circle INSIGHTS Special Edition -Fall 2013 Indiana University Department of Theatre, Drama, + Contemporary DanceIndiana University Department of Theatre, Drama, + Contemporary Dance

    E-Print Network [OSTI]

    Indiana University

    Theatre Circle INSIGHTS Special Edition - Fall 2013Theatre Circle INSIGHTS Special Edition - Fall of the Department of Theatre and Drama and the contemporary dance program. We have "class notes" for alumni from both programs, articles on recent visitors; reunions of alumni in the New York City area and Chicago

  20. Bioenergetics Modeling in the 21st Century: Reviewing New Insights and Revisiting Old Constraints

    E-Print Network [OSTI]

    Bioenergetics Modeling in the 21st Century: Reviewing New Insights and Revisiting Old Constraints.--The development and application of fish bioenergetics models have flourished in recent years, due in part of bioenergetics models can be hampered by uncertainty in model parameters. A review of the literature showed

  1. Currents and turbulence within a kelp forest (Macrocystis pyrifera): Insights from a dynamically scaled laboratory model

    E-Print Network [OSTI]

    Denny, Mark

    coastal ocean because of the combination of smaller turbulent eddies and reduced currents. The decreaseCurrents and turbulence within a kelp forest (Macrocystis pyrifera): Insights from a dynamically pyrifera forest on currents and turbulence were investigated in a controlled laboratory setting using

  2. Selectivity of terrestrial gastropod extinctions on an oceanic archipelago and insights into the

    E-Print Network [OSTI]

    Roy, Kaustuv

    Selectivity of terrestrial gastropod extinctions on an oceanic archipelago and insights to widespread extinctions of spe- cies on oceanic islands but the nature of many of these extinctions remains alive, but among the surviving species, ranges of those that are currently declining due to human

  3. Global warming and changes in risk of concurrent climate extremes: Insights from the 2014

    E-Print Network [OSTI]

    AghaKouchak, Amir

    Global warming and changes in risk of concurrent climate extremes: Insights from the 2014 for Hydrometeorology and Remote Sensing, University of California, Irvine, California, USA Abstract Global warming The warming global climate has increased concurrent climatic extremes such as droughts and heat waves [Leonard

  4. Formation of bands and ridges on Europa by cyclic deformation: Insights from analogue wax experiments

    E-Print Network [OSTI]

    Manga, Michael

    Formation of bands and ridges on Europa by cyclic deformation: Insights from analogue wax perform a set of analogue wax experiments aimed at understanding the processes and conditions that lead to lineament formation on Europa. We heat a layer of wax from below and cool it from above so that a solid

  5. Isotopic fractionations associated with phosphoric acid digestion of carbonate minerals: Insights from first-principles theoretical

    E-Print Network [OSTI]

    Goddard III, William A.

    Isotopic fractionations associated with phosphoric acid digestion of carbonate minerals: Insights 27 May 2009; available online 23 June 2009 Abstract Phosphoric acid digestion has been used with phosphoric acid digestion of carbonates at 25 °C are 10.72&, 0.220&, 0.137&, 0.593& for, respectively, 18 O

  6. The Chaotic Nature of Human Experience: Insights on the Subject Matter of Design towards

    E-Print Network [OSTI]

    Mutlu, Bilge

    The Chaotic Nature of Human Experience: Insights on the Subject Matter of Design towards," as Design has no fixed subject matter but the entire scope of human experience. I argue that human" of the subject matter of design that is #12;iv "human experience." My thesis essay is an attempt to explore

  7. The thermal structure of continental crust in active orogens: insight fromMioceneeclogiteandgranulitexenolithsofthePamirMountains

    E-Print Network [OSTI]

    Meyers, Stephen R.

    The thermal structure of continental crust in active orogens: insight from in the Pamir Mountains, southeastern Tajikistan, preserve a compositional and thermal record at mantle depths. The extraction depths exceed the present-day Pamir Moho at 65 km depth and suggest an average thermal gradient

  8. The Palladium Component of an Immobilized Sonogashira Catalyst System: New Insights by Multinuclear HRMAS NMR Spectroscopy

    E-Print Network [OSTI]

    Bluemel, Janet

    The Palladium Component of an Immobilized Sonogashira Catalyst System: New Insights by Multinuclear: Multinuclear one- and two-dimensional HRMAS NMR spectroscopy has been used to investigate the palladium of palladium bis(phosphine) complexes are possible,8 the steric demand of the phosphine substituents favors

  9. DOI: 10.1002/cctc.201300401 New Insights into the Oxidative Coupling of Methane from

    E-Print Network [OSTI]

    Senkan, Selim M.

    DOI: 10.1002/cctc.201300401 New Insights into the Oxidative Coupling of Methane from Spatially coupling of methane (OCM) is a high-temperature process involving the transformation of methane into ethane oxidation of methane to produce CO and H2 in a Pt- and Rh-coated a-Al2O3 foam.[11­13] Experiments were

  10. Insights from Agricultural and Forestry GHG Offset Bruce A. McCarl

    E-Print Network [OSTI]

    McCarl, Bruce A.

    suitable. This diversity across the landscape causes differential production alterations and greenhouse gas regimes as well as in association with mitigation (i.e. carbon price) incentives. This paper draws upon. The basic nature of the insights to be discussed will arise from studies of the portfolio share of various

  11. Welding processes in volcanology: insights from field, experimental, and modeling studies

    E-Print Network [OSTI]

    Russell, Kelly

    Welding processes in volcanology: insights from field, experimental, and modeling studies Anita This volume is a collection of ten papers largely derived from a special session, Welding Processes, experimental, and modeling studies. We briefly review advances in understanding welding as represented

  12. Welding: insights from high-temperature analogue experiments Steven L. Quane, J.K. Russell*

    E-Print Network [OSTI]

    Russell, Kelly

    Welding: insights from high-temperature analogue experiments Steven L. Quane, J.K. Russell* Igneous of pyroclastic deposits during welding is incompletely understood and is based on a surprisingly small number roles of emplacement temperature, load and glass transition temperature in welding of pyroclastic

  13. Fisheries bycatch data provide insights into the distribution of the mauve stinger (Pelagia noctiluca) around Ireland

    E-Print Network [OSTI]

    Hays, Graeme

    Davenport1,2, and Thomas K. Doyle1 1 Coastal and Marine Resources Centre, ERI, University College Cork noctiluca) around Ireland Thomas Bastian1,2*, David Stokes3, Jane E. Kelleher2, Graeme C. Hays4, John., Kelleher, J. E., Hays, G. C., Davenport, J., and Doyle, T. K. 2011. Fisheries bycatch data provide insights

  14. Sudhakar Yedla* and Sarika Kansal Economic insight into municipal solid waste

    E-Print Network [OSTI]

    Columbia University

    Sudhakar Yedla* and Sarika Kansal Economic insight into municipal solid waste management in Mumbai approach and market instruments have been proved to st: '~ngthen waste management [4]. Mumbai, the largest study examines various reasons for the failure of the MSW management system in Mumbai. Further, it gives

  15. Insights into the Evolution of Vitamin B12 Auxotrophy from Sequenced Algal Genomes

    E-Print Network [OSTI]

    Goldstein, Raymond E.

    Insights into the Evolution of Vitamin B12 Auxotrophy from Sequenced Algal Genomes Katherine E Abstract Vitamin B12 (cobalamin) is a dietary requirement for humans because it is an essential cofactor microalgal species need the vitamin as a growth supplement, but there is no phylogenetic relationship between

  16. Charge separation in nanoscale photovoltaic materials: recent insights from first-principles electronic structure theory

    E-Print Network [OSTI]

    Wu, Zhigang

    Charge separation in nanoscale photovoltaic materials: recent insights from first-scale photovoltaic materials; in particular recent theoretical/computational work based on first principles electron and hole in so-called excitonic photovoltaic cells. Emphasis is placed on theoretical results

  17. Carbon Footprint and the Management of Supply Chains: Insights from Simple Models

    E-Print Network [OSTI]

    Benjaafar, Saifallah

    Carbon Footprint and the Management of Supply Chains: Insights from Simple Models Saif Benjaafar1-making that accounts for both cost and carbon footprint. We examine how the values of these parameters as well or shareholders, are undertaking initiatives to reduce their carbon footprint. However, these initiatives have

  18. Hazard/Risk Assessment MULTIPLE STRESSORS AND COMPLEX LIFE CYCLES: INSIGHTS FROM A

    E-Print Network [OSTI]

    Hopkins, William A.

    Hazard/Risk Assessment MULTIPLE STRESSORS AND COMPLEX LIFE CYCLES: INSIGHTS FROM A POPULATION with complex life cycles, population models may be useful in understanding impacts of stressors that are unique to the habitat type (aquatic, terrestrial) and that operate at different times in the life cycle. We investigated

  19. Thorium isotopes in the western Mediterranean Sea: an insight into the marine particle dynamics

    E-Print Network [OSTI]

    Coppola, Laurent

    Thorium isotopes in the western Mediterranean Sea: an insight into the marine particle dynamics M rights reserved. Keywords: thorium; isotopes; sea water; particles; sedimentation; Mediterranean Sea 1 physical, chemical and biological processes and sometimes non-steady-state condi- tions [1^4]. Thorium

  20. The water-benzene interaction: Insight from electronic structure theories Jie Ma,1,2,3

    E-Print Network [OSTI]

    Alfè, Dario

    The water-benzene interaction: Insight from electronic structure theories Jie Ma,1,2,3 Dario Alfè,2 theories is challenging. Here we assess the ability of a variety of theories to describe a water-benzene- tween water and benzene. Water benzene is an interesting model system because it is a reasonably small

  1. INSIGHT: Internet-Sensor Integration for Habitat Monitoring Murat Demirbas Ken Yian Chow Chieh Shyan Wan

    E-Print Network [OSTI]

    Krovi, Venkat

    strength monitoring system, we investigate monitoring of a controlled, small environment via WSN. We seeINSIGHT: Internet-Sensor Integration for Habitat Monitoring Murat Demirbas Ken Yian Chow Chieh, and deploying of an Internet accessible wireless sensor network for monitoring of the temperature, humidity

  2. Atomistic insights into Li-ion diffusion in amorphous silicon , Afif Gouissem a

    E-Print Network [OSTI]

    Sharma, Pradeep

    are a critical part of the future energy storage needs in a broad range of applica- tions: portable electronics is currently focused on understanding the basic materials science underscoring these energy storage devicesAtomistic insights into Li-ion diffusion in amorphous silicon Xin Yan a , Afif Gouissem a , Pradeep

  3. Theoretical insight into ArO surface-wave microwave discharges

    E-Print Network [OSTI]

    Guerra, Vasco

    Theoretical insight into Ar­O 2 surface-wave microwave discharges This article has been downloaded-wave microwave discharges Kinga Kutasi1 , Vasco Guerra2 and Paulo S´a2,3 1 Research Institute for Solid State electron and heavy-particle kinetics in Ar­O2 surface-wave microwave discharges generated in long

  4. Insights into the structural evolution of amniote genomes A. Ouangraoua1,2

    E-Print Network [OSTI]

    Chauve, Cedric

    Insights into the structural evolution of amniote genomes A. Ouangraoua1,2 , A. McPherson1 , C contiguous ancestral regions (CARs) of the genome of the last common ancestor of all extant amniotes. We use the complete genome sequences and assemblies of 14 vertebrate species: 11 amniote genomes as ingroups and 3

  5. Using System Dynamics to Extend Real Options Use: Insights from the Oil & Gas Industry

    E-Print Network [OSTI]

    Ford, David N.

    Using System Dynamics to Extend Real Options Use: Insights from the Oil & Gas Industry Scott to real options through work with a major energy firm to apply real options. Five key challenges facing the real options community are presented and potential system dynamics contributions to these challenges

  6. Hybrid Zones and Sexual Selection 503 HYBRID ZONES AND SEXUAL SELECTION: INSIGHTS FROM

    E-Print Network [OSTI]

    Hybrid Zones and Sexual Selection 503 HYBRID ZONES AND SEXUAL SELECTION: INSIGHTS FROM THE AWASH BABOON HYBRID ZONE (Papio hamadryas anubis x P. h. hamadryas) Thore J. Bergman and Jacinta C. Beehner, have focused on the impact of sexual selection on populations of naturally occurring hybrid animals

  7. ERDC/EL TN-11-1 Flood Risk Management: Insights from

    E-Print Network [OSTI]

    US Army Corps of Engineers

    ERDC/EL TN-11-1 March 2011 Flood Risk Management: Insights from an Expert Modeling Process by M. D preparedness planning that harmonizes efforts of implementing agencies and stakeholders. Risk management are essential for effective risk management policy. Formal (versus ad hoc) analyses of risk manager and stake

  8. Large-volume Rhyolite Genesis in Caldera Complexes of the Snake River Plain: Insights

    E-Print Network [OSTI]

    Bindeman, Ilya N.

    Large-volume Rhyolite Genesis in Caldera Complexes of the Snake River Plain: Insights from-volume rhyolites in the shallow crust is an im- portant, yet enigmatic, process in the Snake River Plain and world; rhyolite; Snake River Plain, zircon *Corresponding author. E-mail: kwatts@uoregon.edu y E-mail: address

  9. Branching morphogenesis of the lung: new molecular insights into an old

    E-Print Network [OSTI]

    Chuang, Pao-Tien

    Branching morphogenesis of the lung: new molecular insights into an old problem Pao-Tien Chuang1 It has been known for decades that branching morpho- genesis of the lung is mediated through reciprocal between major signaling path- ways during branching morphogenesis of the lung in mice. It has been known

  10. Static and flowing regions in granular collapses down channels: Insights from a sedimenting shallow water model

    E-Print Network [OSTI]

    Huppert, Herbert

    Static and flowing regions in granular collapses down channels: Insights from a sedimenting shallow extend the model of Larrieu 2006 to include an estimation for the interface between the static, 043301 2007 . An empirical sedimentation term Ls and the instantaneous removal of a static deposit wedge

  11. Anatomy of Bridge Flutter: Some New Insights Xinzhong Chen, Ahsan Kareem

    E-Print Network [OSTI]

    Kareem, Ahsan

    Anatomy of Bridge Flutter: Some New Insights Xinzhong Chen, Ahsan Kareem NatHaz Modeling Laboratory accuracy and effectiveness are demonstrated through a flutter analysis of a cable-stayed bridge and aerodynamics on bridge flutter, which helps in better tailoring of the bridge structural systems and deck

  12. Carbon pathways to zooplankton: insights from the combined use of stable isotope and fatty acid biomarkers

    E-Print Network [OSTI]

    Mazumder, Asit

    Carbon pathways to zooplankton: insights from the combined use of stable isotope and fatty acid quantified the relative contribution of terrestrial- and phytoplankton-derived carbon sources to zooplankton secondary production in lakes. However, few investigated the pathways along which allochthonous

  13. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin{

    E-Print Network [OSTI]

    Zhao, Huimin

    New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin{ Ryan D shown in Scheme 1A.4­11 Yet, the mechanism of an unprecedented methyl transfer step in the biosynthesis in combina- tion with bioinformatics analysis lead to a radically different mechanism

  14. Seismogenic patterns in the Taiwan region: insights from source parameter inversion of BATS data

    E-Print Network [OSTI]

    Lin, Andrew Tien-Shun

    Seismogenic patterns in the Taiwan region: insights from source parameter inversion of BATS data Honn Kao*, Pei-Ru Jian Institute of Earth Sciences, Academia Sinica, Taipei, Taiwan, ROC Received 1 earthquakes that occurred in the Taiwan region between July 1995 and June 1998, using waveforms recorded

  15. Topological Aspects of DNA Function and Protein Folding 559 Structural insights into the role of architectural

    E-Print Network [OSTI]

    Swigon, David

    Topological Aspects of DNA Function and Protein Folding 559 Structural insights into the role of architectural proteins in DNA looping deduced from computer simulations Wilma K. Olson*1 , Michael A. Grosner. The intervening residues form loops, which are organized by the binding of various proteins. For example

  16. insight review articles NATURE | VOL 418 | 8 AUGUST 2002 | www.nature.com/nature 671

    E-Print Network [OSTI]

    Wang, Changlu

    insight review articles NATURE | VOL 418 | 8 AUGUST 2002 | www.nature.com/nature 671 T he benefits the ability of people to better reach their mental and physical potential) and sparing natural ecosystems from agricul- ture4 . In addition to causing the loss of natural ecosystems, agriculture adds globally

  17. Bright and dark excitons in semiconductor carbon nanotubes: insights from electronic structure calculations

    E-Print Network [OSTI]

    Tretiak, Sergei

    Bright and dark excitons in semiconductor carbon nanotubes: insights from electronic structure Article on the web 23rd March 2009 DOI: 10.1039/b818473a We review electronic structure calculations (bright) and optically forbidden (dark) states from the lowest excitonic band of the nanotubes

  18. A new hydrothermal scenario for the 2006 Lusi eruption, Indonesia. Insights from gas geochemistry

    E-Print Network [OSTI]

    Mazzini, Adriano

    acquired a wide set of data of molecular and isotopic composition of gas sampled in several Lusi vents, in the surrounding mud volcanoes, in the closest natural gas field (Wunut), and in the hydrothermal ventsA new hydrothermal scenario for the 2006 Lusi eruption, Indonesia. Insights from gas geochemistry

  19. Is the Internet for Porn? An Insight Into the Online Adult Industry

    E-Print Network [OSTI]

    Kruegel, Christopher

    Is the Internet for Porn? An Insight Into the Online Adult Industry Gilbert Wondracek1 , Thorsten Introduction "The Internet is for Porn" is the title of a satirical song that has been viewed several million at work. With a total worth of more than 97 billion USD in 2006 [14], the Internet porn industry yields

  20. INSIGHT On Transforming Our Global Energy Economy, 2015 Annual Report (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2015-03-01

    From its inception, JISEA has provided critical clarity and insights to inform decision making through leading-edge interdisciplinary research and objective, credible, cross-functional analysis. JISEA, drawing on the unique capabilities of its founding institutions and research affiliates around the world, continues to inform the landscape of transformation.

  1. Insights into the Evolution of Longevity from the Bowhead Whale Genome

    E-Print Network [OSTI]

    de Magalhães, João Pedro

    and Natural Resources, Purdue University, West Lafayette, IN 47907, USA 15North Slope Borough, DepartmentResource Insights into the Evolution of Longevity from the Bowhead Whale Genome Graphical Abstract Correspondence jp@senescence.info In Brief The bowhead whale is the longest-lived mammal, possibly living over

  2. "Our grad math programs are collaborative, creative and insightful." carleton.ca/math

    E-Print Network [OSTI]

    Dawson, Jeff W.

    "Our grad math programs are collaborative, creative and insightful." carleton.ca/math GRADUATE and leadership. More information about individual faculty is available at: carleton.ca/math/research. The School with the University of Ottawa. Together, we offer one of the largest grad programs in math and stats in Canada

  3. On the seismic response of deep-seated rock slope instabilities --Insights from numerical modeling

    E-Print Network [OSTI]

    On the seismic response of deep-seated rock slope instabilities -- Insights from numerical modeling 2015 Accepted 3 April 2015 Available online 15 April 2015 Keywords: Seismic landslide hazard Spectral component of seismic hazard in mountainous regions. While many seismic slope stability analysis methods

  4. Oxygen diffusion in solid oxide fuel cell cathode and electrolyte materials: mechanistic insights from atomistic simulations

    E-Print Network [OSTI]

    Yildiz, Bilge

    oxide fuel cells are of technological interest as they offer high efficiency for energy conversion to drive fast ionic transport. 1. Introduction The interest in Solid Oxide Fuel Cell (SOFC) technologyOxygen diffusion in solid oxide fuel cell cathode and electrolyte materials: mechanistic insights

  5. Contractional deformation of porous sandstone: Insights from the Aztec Sandstone, SE Nevada, USA

    E-Print Network [OSTI]

    Fossen, Haakon

    Contractional deformation of porous sandstone: Insights from the Aztec Sandstone, SE Nevada, USA Available online 19 March 2015 Keywords: Sevier thrusting Porous sandstone deformation Deformation bands Contractional deformation a b s t r a c t Contractional deformation of highly porous sandstones is poorly

  6. Insights into aging through measurements of the Drosophila proteome as a function of temperature

    E-Print Network [OSTI]

    Clemmer, David E.

    Insights into aging through measurements of the Drosophila proteome as a function of temperature age (i.e., calendar time in days, months, or years) is used to characterize deteriorative changes associated with aging (Rodwell et al., 2004; Krishnamurthy et al., 2004; Zahn et al., 2006). For example

  7. New insights to cloud seeding for enhancing precipitation and for hail suppression Daniel Rosenfeld

    E-Print Network [OSTI]

    Daniel, Rosenfeld

    New insights to cloud seeding for enhancing precipitation and for hail suppression Daniel Rosenfeld microphysical observations of the impacts of aerosols on cloud microstructure and precipitation forming- forming processes to the role of aerosols in the rate of conversion of cloud droplets into precipitation

  8. IN-FORUM http://www.in-forum.com/articles/index.cfm?id=98106§ion=Opinion 1 of 2 7/20/2005 2:48 PM

    E-Print Network [OSTI]

    Patzek, Tadeusz W.

    that Pimental and Patzek would come to their anti-ethanol findings. Both have ties to the oil industry. (See accepts the flawed Pimental/Patzek energy in, energy out data. Furthermore, the record-high pump price

  9. IN-FORUM http://www.in-forum.com/articles/index.cfm?id=98107§ion=Opinion 1 of 2 7/20/2005 2:44 PM

    E-Print Network [OSTI]

    Patzek, Tadeusz W.

    Archive Company Site Ethics Code E-Mail Index InfoGuide Newspapers in Education Public Notices Resources) as if it is the gospel truth. Pimentel's studies have been routinely discredited by officials from the Departments

  10. Inforum/Information Services, Faculty of Information, University of Toronto (March 2014) 1 Antonelli, Monika, & McCullough, Mark (Eds.). (2012). Greening libraries. Los Angeles

    E-Print Network [OSTI]

    Toronto, University of

    2012-01-01

    , such as alternative energy resources, green library services, operations, programming, and outreach are explored to practically address issues ranging from recycling and creating green exhibits, to conducting energy auditsCullough, Mark (Eds.). (2012). Greening libraries. Los Angeles: Library Juice Press. 027 G8131G Greening

  11. Analysis Insights, August 2015: Sustainable Transportation; NREL (National Renewable Energy Laboratory)

    SciTech Connect (OSTI)

    2015-08-01

    NREL Analysis Insights mines our body of analysis work to synthesize topical insights and key findings. In this issue, we examine transportation systems, alternative fuels, and implications of increasing electrification of transit. Moving people and goods from point A to B has never been easier, but our current transportation systems also take a toll on our environment. Transportation currently accounts for 71% of total U.S. petroleum use and 33% of the nation’s total carbon emissions. With new technology, can we make our transportation system cleaner and more cost effective? NREL is applying its analytical expertise and imagination to do just that. Solutions start with systems thinking. Connecting the dots between physical components - vehicles, fueling stations, and highways - and institutional components - traffic laws, regulations, and vehicle standards - helps illuminate solutions that address the needs of the transportation system's many stakeholders.

  12. Wing Shape of Four New Bee Fossils (Hymenoptera: Anthophila) Provides Insights to Bee Evolution

    E-Print Network [OSTI]

    Dehon, Manuel; Michez, Denis; Nel, André Engel, Michael S.; De Meulemeester, Thibaut

    2014-10-29

    insights into more recent phenomena among bee evolution, such as changing patterns of biogeography and responses to Paleogene and Neogene geological events. Four of the most important deposits with bee fossils are the Eckfeld/Messel oil shales of Germany... compressions in oil shale. The flora found in this section of the basin suggests a tropical to subtropical climate with a distinct dry season [37], and occurred at a paleoelevation of ,1500–2900 m [38]. The Oligocene lacustrine beds (‘calcaire de Campagne...

  13. Cross-sector policy research: insights from the UK energy and transport sectors

    E-Print Network [OSTI]

    Peake, Stephen Robert

    1993-10-26

    : Insights from the UK energy and transport sectors Stephen Robert Peake Darwin College, Cambridge UNIVERSITY I ltBRARY J CAMBRIDGE A dissertation submitted to the University of Cambridge for the Degree of Doctor of Philosophy. June 1993 Dedication... . To Sarah and Charlie, for all their love and support. Declaration. I declare that except for commonly understood and accepted ideas, or where specific reference is made, the work reported in this dissertation is my own. It includes nothing which...

  14. New Whole-House Solutions Case Study: Insight Homes, Seaford, Delaware

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills and Reduce Carbon Pollution |ofNewInsight Homes of Bridgeville,

  15. Insights from Smart Meters: The Potential for Peak-Hour Savings from Behavior-Based Programs

    SciTech Connect (OSTI)

    Todd, Annika; Perry, Michael; Smith, Brian; Sullivan, Michael; Cappers, Peter; Goldman, Charles

    2014-03-25

    The rollout of smart meters in the last several years has opened up new forms of previously unavailable energy data. Many utilities are now able in real-time to capture granular, household level interval usage data at very high-frequency levels for a large proportion of their residential and small commercial customer population. This can be linked to other time and locationspecific information, providing vast, constantly growing streams of rich data (sometimes referred to by the recently popular buzz word, “big data”). Within the energy industry there is increasing interest in tapping into the opportunities that these data can provide. What can we do with all of these data? The richness and granularity of these data enable many types of creative and cutting-edge analytics. Technically sophisticated and rigorous statistical techniques can be used to pull interesting insights out of this highfrequency, human-focused data. We at LBNL are calling this “behavior analytics”. This kind of analytics has the potential to provide tremendous value to a wide range of energy programs. For example, highly disaggregated and heterogeneous information about actual energy use would allow energy efficiency (EE) and/or demand response (DR) program implementers to target specific programs to specific households; would enable evaluation, measurement and verification (EM&V) of energy efficiency programs to be performed on a much shorter time horizon than was previously possible; and would provide better insights in to the energy and peak hour savings associated with specifics types of EE and DR programs (e.g., behavior-based (BB) programs). In this series, “Insights from Smart Meters”, we will present concrete, illustrative examples of the type of value that insights from behavior analytics of these data can provide (as well as pointing out its limitations). We will supply several types of key findings, including: • Novel results, which answer questions the industry previously was unable to answer; • Proof-of-concept analytics tools that can be adapted and used by others; and • Guidelines and protocols that summarize analytical best practices. This report focuses on one example of the kind of value that analysis of this data can provide: insights into whether behavior-based (BB) efficiency programs have the potential to provide peak-hour energy savings.

  16. Bioinformatics and Biology Insights 2010:4 18 This article is available from http://www.la-press.com.

    E-Print Network [OSTI]

    Bioinformatics and Biology Insights 2010:4 1­8 This article is available from http://www.la-press access to this and thousands of other papers at http://www.la-press.com. Bioinformatics and Biology

  17. Insights on Curriculum, Instruction, and Early Literacy Learning: Student Characteristic by Instruction Interaction Effects on Literacy Outcomes

    E-Print Network [OSTI]

    Rose, Michael R.

    in focusing students' attention on learning activities within grade, from grade Insights on Curriculum, Instruction, and Early Literacy Learning: Student focused on children's learning in the classroom ­ from preschool through third

  18. Oak Ridge Centers for Manufacturing Technology „ Insights from Jack Cook

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeeding access to scienceSpeeding accessScientificandThe ManufacturingInsights

  19. Development of Integrated Motor Assist Hybrid System: Development of the 'Insight', a Personal Hybrid Coupe

    SciTech Connect (OSTI)

    Kaoru Aoki; Shigetaka Kuroda; Shigemasa Kajiwara; Hiromitsu Sato; Yoshio Yamamoto

    2000-06-19

    This paper presents the technical approach used to design and develop the powerplant for the Honda Insight, a new motor assist hybrid vehicle with an overall development objective of just half the fuel consumption of the current Civic over a wide range of driving conditions. Fuel consumption of 35km/L (Japanese 10-15 mode), and 3.4L/100km (98/69/EC) was realized. To achieve this, a new Integrated Motor Assist (IMA) hybrid power plant system was developed, incorporating many new technologies for packaging and integrating the motor assist system and for improving engine thermal efficiency. This was developed in combination with a new lightweight aluminum body with low aerodynamic resistance. Environmental performance goals also included the simultaneous achievement of low emissions (half the Japanese year 2000 standards, and half the EU2000 standards), high efficiency, and recyclability. Full consideration was also given to key consumer attributes, including crash safety performance, handling, and driving performance.

  20. 2010 Honda Insight VIN 0141 Hybrid Electric Vehicle Battery Test Results

    SciTech Connect (OSTI)

    Tyler Gray

    2013-01-01

    The U.S. Department of Energy Advanced Vehicle Testing Activity Program consists of vehicle, battery, and infrastructure testing on advanced technology related to transportation. The activity includes tests on hybrid electric vehicles (HEVs), including testing the HEV batteries when both the vehicles and batteries are new and at the conclusion of 160,000 miles of on road fleet testing. This report documents battery testing performed for the 2010 Honda Insight HEV (VIN: JHMZE2H78AS010141). Battery testing was performed by the Electric Transportation Engineering Corporation dba ECOtality North America. The Idaho National Laboratory and ECOtality North America collaborate on the Advanced Vehicle Testing Activity for the Vehicle Technologies Program of the U.S. Department of Energy.

  1. 2010 Honda Insight VIN 1748 Hybrid Electric Vehicle Battery Test Results

    SciTech Connect (OSTI)

    Tyler Gray; Matthew Shirk

    2013-01-01

    The U.S. Department of Energy Advanced Vehicle Testing Activity Program consists of vehicle, battery, and infrastructure testing on advanced technology related to transportation. The activity includes tests on hybrid electric vehicles (HEVs), including testing the HEV batteries when both the vehicles and batteries are new and at the conclusion of 160,000 miles of on road fleet testing. This report documents battery testing performed for the 2010 Honda Insight HEV (VIN: JHMZE2H59AS011748). Battery testing was performed by the Electric Transportation Engineering Corporation dba ECOtality North America. The Idaho National Laboratory and ECOtality North America collaborate on the Advanced Vehicle Testing Activity for the Vehicle Technologies Program of the U.S. Department of Energy.

  2. Insights from Investigations of In-Vessel Retention for High Powered Reactors

    SciTech Connect (OSTI)

    Joy L. Rempe

    2005-10-01

    In a three-year U.S. - Korean International Nuclear Energy Research Initiative (INERI), state-of-the-art analytical tools and key U.S. and Korean experimental facilities were used to explore two options, enhanced ERVC performance and the use of internal core catchers, that have the potential to increase the margin for in-vessel retention (IVR) in high power reactors (up to 1500 MWe). This increased margin has the potential to improve plant economics (owing to reduced regulatory requirements) and increase public acceptance (owing to reduced plant risk). Although this program focused upon the Korean Advanced Power Reactor -- 1400 MWe (APR 1400) design, recommentations were developed so that they can easily be applied to a wide range of existing and advanced reactor designs. This paper summarizes new data gained for evaluating the margin associated with various options investigated in this program. Insights from analyses completed with this data are also highlighted.

  3. Mobilizing Public Markets to Finance Renewable Energy Projects: Insights from Expert Stakeholders

    SciTech Connect (OSTI)

    Schwabe, P.; Mendelsohn, M.; Mormann, F.; Arent, D. J.

    2012-06-01

    Financing renewable energy projects in the United States can be a complex process. Most equity investment in new renewable power production facilities is supported by tax credits and accelerated depreciation benefits, and is constrained by the pool of potential investors that can fully use these tax benefits and are willing to engage in complex financial structures. For debt financing, non-government lending has largely been provided by foreign banks that may be under future lending constraints due to economic and regulatory conditions. To discuss renewable energy financing challenges and to identify new sources of capital to the U.S. market, two roundtable discussions were held with renewable energy and financing experts in April 2012. This report summarizes the key messages of those discussions and is designed to provide insights to the U.S. market and inform the international conversation on renewable energy financing innovations.

  4. Crystal Structures of Human and Staphylococcus aureus Pyruvate Carboxylase and Molecular Insights into the Carboxyltransfer Reaction

    SciTech Connect (OSTI)

    Xiang,S.; Tong, L.

    2008-01-01

    Pyruvate carboxylase (PC) catalyzes the biotin-dependent production of oxaloacetate and has important roles in gluconeogenesis, lipogenesis, insulin secretion and other cellular processes. PC contains the biotin carboxylase (BC), carboxyltransferase (CT) and biotin-carboxyl carrier protein (BCCP) domains. We report here the crystal structures at 2.8-Angstroms resolution of full-length PC from Staphylococcus aureus and the C-terminal region (missing only the BC domain) of human PC. A conserved tetrameric association is observed for both enzymes, and our structural and mutagenesis studies reveal a previously uncharacterized domain, the PC tetramerization (PT) domain, which is important for oligomerization. A BCCP domain is located in the active site of the CT domain, providing the first molecular insights into how biotin participates in the carboxyltransfer reaction. There are dramatic differences in domain positions in the monomer and the organization of the tetramer between these enzymes and the PC from Rhizobium etli.

  5. Nikon Instruments Inc. | Resource Center -Research Papers -New insights into DNA repair http://www.nikoninstruments.com/Resource-Center/Research-Papers/New-insights-into-DNA-repair[4/10/2012 10:42:30 AM

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Nikon Instruments Inc. | Resource Center - Research Papers - New insights into DNA repair http:42:30 AM] change locationAMS EN Nikon Instruments Inc. on Facebook Like You like th Page · Ins Resource constrain available 3D conformations and slow the rate of homologous pairing while longer ssDNA strands

  6. *Deborah E. Eason, Garrett Ito, John M. Sinton Insights into melt and chemical transport rates in the mantle

    E-Print Network [OSTI]

    Geist, Dennis

    of glacial melting. Models of mantle decompression following ice sheet removal predict the greatest melt], we model melt migration in the mantle during and after ice sheet removal (glacial unloading*Deborah E. Eason, Garrett Ito, John M. Sinton Insights into melt and chemical transport rates

  7. Initiation of the San Jacinto Fault and its Interaction with the San Andreas Fault: Insights from Geodynamic Modeling

    E-Print Network [OSTI]

    Liu, Mian

    Initiation of the San Jacinto Fault and its Interaction with the San Andreas Fault: Insights from Geodynamic Modeling QINGSONG LI 1,2 and MIAN LIU 1 Abstract--The San Andreas Fault (SAF) is the Pacific is accommodated by the San Jacinto Fault (SJF). Here we investigate the initiation of the SJF and its interaction

  8. On the Vertical Structure of Modeled and Observed Deep Convective Storms: Insights for Precipitation Retrieval and Microphysical Parameterization

    E-Print Network [OSTI]

    Droegemeier, Kelvin K.

    On the Vertical Structure of Modeled and Observed Deep Convective Storms: Insights-GEORGIOU, AND VENUGOPAL VURUPUTUR Saint Anthony Falls Laboratory, Department of Civil Engineering, University of Minnesota of hydrometeors (liquid and frozen water droplets in a cloud) produced by high-resolution NWP models with explicit

  9. The Independent Sign Bias: Gaining Insight from Multiple Linear Regression Michael J. Pazzani (pazzani@ics.uci.edu)

    E-Print Network [OSTI]

    Pazzani, Michael J.

    this insightful or advise anyone to act upon this model. If a baseball player interested in maximizing his income guide future decision-making. For example, many lenders use a credit score to help determine whether to make a loan. This score is a combination of many factors such as income, debt, and past payment history

  10. Insight into the Molecular Arrangement of High-Density Polyethylene Polymer Chains in Blends of Polystyrene/High-

    E-Print Network [OSTI]

    Insight into the Molecular Arrangement of High-Density Polyethylene Polymer Chains in Blends of Polystyrene/High- Density Polyethylene from Differential Scanning Calorimetry and Raman Techniques JAYANT/high-density polyethylene (PS/HDPE) blends were synthe- sized by melt blending in a single screw extruder. Co

  11. Ahmed, Rose, Figliozzi & Jacob 1 Commuter Cyclist's Sensitivity to Changes in Weather: Insight from Two Cities with

    E-Print Network [OSTI]

    Bertini, Robert L.

    Ahmed, Rose, Figliozzi & Jacob 1 Commuter Cyclist's Sensitivity to Changes in Weather: Insight from between various weather conditions and commuter bicyclist volume in two cities (Portland, USA and Brisbane may condition bicyclist's responsiveness to changes in weather and climate. Temporal variations

  12. Boys are like Girls: Insights in the Gender Digital Divide in Higher Education in Switzerland and Europe

    E-Print Network [OSTI]

    Boys are like Girls: Insights in the Gender Digital Divide in Higher Education in Switzerland Switzerland, Locarno, Switzerland luca.botturi@supsi.ch) Chiara Bramani (New Media in Education Laboratory, University of Lugano, Switzerland chiara.bramani@usi.ch) Sean McCusker (School of Education, Durham

  13. Wind of change: new insights on the ecology and evolution of pollination and mating in wind-pollinated plants

    E-Print Network [OSTI]

    Barrett, Spencer C.H.

    . For example, traits such as small, unisexual flowers and dry pollen may facilitate tran- sitions to windREVIEW Wind of change: new insights on the ecology and evolution of pollination and mating in wind- pollinated plants. At least 10 % of angiosperms are wind pollinated, and this mode of pollination has evolved

  14. Penetration of UV-visible solar radiation in the global oceans: Insights from ocean color remote sensing

    E-Print Network [OSTI]

    Penetration of UV-visible solar radiation in the global oceans: Insights from ocean color remote 2013. [1] Penetration of solar radiation in the ocean is determined by the attenuation coefficient (Kd indicated that the penetration of the blue-green radiation for most oceanic waters is $30­40% deeper than

  15. New insights into the subglacial and periglacial hydrology of Vatnajo kull, Iceland, from a distributed physical model

    E-Print Network [OSTI]

    Flowers, Gwenn

    New insights into the subglacial and periglacial hydrology of Vatnajo« kull, Iceland, from, University of Iceland, Dunhaga 3, IS-107 ReykjavõÂk, Iceland E-mail: flowers@geop.ubc.ca ABSTRACT. We apply a time-dependent distributed glaciohydraulic model to Vatna- jo« kull ice cap, Iceland, aiming

  16. One-Dimensional Barrier-Preserving Free-Energy Projections of a -sheet Miniprotein: New Insights into the Folding Process

    E-Print Network [OSTI]

    Caflisch, Amedeo

    One-Dimensional Barrier-Preserving Free-Energy Projections of a -sheet Miniprotein: New Insights simulations for a total of 20 µs. The resulting one-dimensional free-energy profiles (FEPs) provide a detailed description of the free-energy basins and barriers for the folding reaction. The similarity of the FEPs

  17. Tectonics of the Middle Triassic intracontinental Xuefengshan Belt, South China: new insights from structural and chronological constraints on the basal

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Tectonics of the Middle Triassic intracontinental Xuefengshan Belt, South China: new insights-012-0780-5 #12;2 Abstract: In orogenic belts, a basal décollement zone often develops at depth to accommodate Xuefengshan Belt of South China, such a décollement zone is exposed in the core of anticlines formed

  18. Reaction pathways by quantum Monte Carlo: Insight on the torsion barrier of 1,3-butadiene, and the conrotatory ring opening of cyclobutene

    E-Print Network [OSTI]

    Guidoni, Leonardo

    Reaction pathways by quantum Monte Carlo: Insight on the torsion barrier of 1,3-butadiene: Insight on the torsion barrier of 1,3-butadiene, and the conrotatory ring opening of cyclobutene Matteo to investigate the intramolecular reaction pathways of 1,3-butadiene. The ground state geometries of the three

  19. Computational insights of water droplet transport on graphene sheet with chemical density

    SciTech Connect (OSTI)

    Zhang, Liuyang; Wang, Xianqiao, E-mail: xqwang@uga.edu [College of Engineering and NanoSEC, University of Georgia, Athens, Georgia 30602 (United States)

    2014-05-21

    Surface gradient has been emerging as an intriguing technique for nanoscale particle manipulation and transportation. Owing to its outstanding and stable chemical properties, graphene with covalently bonded chemical groups represents extraordinary potential for the investigation of nanoscale transport in the area of physics and biology. Here, we employ molecular dynamics simulations to investigate the fundamental mechanism of utilizing a chemical density on a graphene sheet to control water droplet motions on it. Simulation results have demonstrated that the binding energy difference among distinct segment of graphene in terms of interaction between the covalently bonded oxygen atoms on graphene and the water molecules provides a fundamental driving force to transport the water droplet across the graphene sheet. Also, the velocity of the water droplet has showed a strong dependence on the relative concentration of oxygen atoms between successive segments. Furthermore, a multi-direction channel provides insights to guide the transportation of objects towards a targeted position, separating the mixtures with a system of specific chemical functionalization. Our findings shed illuminating lights on the surface gradient method and therefore provide a feasible way to control nanoscale motion on the surface and mimic the channelless microfluidics.

  20. Section 1603 Treasury Grant Expiration. Industry Insight on Financing and Market Implications

    SciTech Connect (OSTI)

    Mendelsohn, Michael; Harper, John

    2012-06-01

    In the wake of the 2008-2009 financial crises, tax equity investors largely withdrew from the market, resulting in stagnation of project development. In response, Congress established the Treasury grant program pursuant to Section 1603 of the American Recovery and Reinvestment Act (Section 1603 Program) to offer a cash payment in lieu of a production and investment tax credit. This study addresses the likely project financing and market impacts from the expiration of the Section 1603 Program. The authors assembled an array of insights offered by financial executives active in the renewable energy (RE) market during conference panel discussions and in presentations, direct interviews, and email correspondences. This analysis found that the Section 1603 Program alleviated the need to monetize the tax credit incentives through specialized investors, helped lower the transaction and financing costs associated with renewable electricity projects, and generally supported an extensive build-out of renewable power generation capacity. With the expiration of the Section 1603 Program, smaller or less-established renewable power developers will have more difficulty attracting needed financial capital and completing their projects, development of projects relying on newer or 'innovative' technologies will likely slow as traditional tax equity investors are known to be highly averse to technology risk in the projects they fund, and, finally, projects relying on tax equity may be more expensive to develop due to higher transaction costs and potentially higher yields required to attract tax equity.

  1. Section 1603 Treasury Grant Expiration: Industry Insight on Financing and Market Implications

    SciTech Connect (OSTI)

    Mendelsohn, M.; Harper, J.

    2012-06-01

    In the wake of the 2008-2009 financial crises, tax equity investors largely withdrew from the market, resulting in stagnation of project development. In response, Congress established the Treasury grant program pursuant to Section 1603 of the American Recovery and Reinvestment Act (..Section..1603 Program) to offer a cash payment in lieu of a production and investment tax credit. This study addresses the likely project financing and market impacts from the expiration of the ..Section..1603 Program. The authors assembled an array of insights offered by financial executives active in the renewable energy (RE) market during conference panel discussions and in presentations, direct interviews, and email correspondences. This analysis found that the ..Section..1603 Program alleviated the need to monetize the tax credit incentives through specialized investors, helped lower the transaction and financing costs associated with renewable electricity projects, and generally supported an extensive build-out of renewable power generation capacity. With the expiration of the ..Section..1603 Program, smaller or less-established renewable power developers will have more difficulty attracting needed financial capital and completing their projects, development of projects relying on newer or 'innovative' technologies will likely slow as traditional tax equity investors are known to be highly averse to technology risk in the projects they fund, and, finally, projects relying on tax equity may be more expensive to develop due to higher transaction costs and potentially higher yields required to attract tax equity.

  2. Structural Insight into the Mechanisms of Enveloped Virus Tethering by Tetherin

    SciTech Connect (OSTI)

    H Yang; J Wang; X Jia; M McNatt; T Zang; B Pan; W Meng; H Wang; P Bieniasz; Y Xiong

    2011-12-31

    Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that tetherin forms a continuous alpha helix encompassing almost the entire ectodomain. Tetherin helices dimerize into parallel coiled coils via interactions throughout the C-terminal portion of the ectodomain. A comparison of the multiple structures of the tetherin dimer reveals inherent constrained flexibility at two hinges positioned at residues A88 and G109. In the crystals, two tetherin ectodomain dimers associate into a tetramer by forming an antiparallel four-helix bundle at their N termini. However, mutagenesis studies suggest that the tetrametric form of tetherin, although potentially contributing to, is not essential for its antiviral activity. Nonetheless, the structural and chemical properties of the N terminus of the ectodomain are important for optimal tethering function. This study provides detailed insight into the mechanisms by which this broad-spectrum antiviral restriction factor can function.

  3. Structural insight into the mechanisms of enveloped virus tethering by tetherin

    SciTech Connect (OSTI)

    Yang, Haitao; Wang, Jimin; Jia, Xiaofei; McNatt, Matthew W.; Zang, Trinity; Pan, Baocheng; Meng, Wuyi; Wang, Hong-Wei; Bieniasz, Paul D.; Xiong, Yong (Yale); (Rockefeller)

    2010-11-10

    Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that tetherin forms a continuous alpha helix encompassing almost the entire ectodomain. Tetherin helices dimerize into parallel coiled coils via interactions throughout the C-terminal portion of the ectodomain. A comparison of the multiple structures of the tetherin dimer reveals inherent constrained flexibility at two hinges positioned at residues A88 and G109. In the crystals, two tetherin ectodomain dimers associate into a tetramer by forming an antiparallel four-helix bundle at their N termini. However, mutagenesis studies suggest that the tetrametric form of tetherin, although potentially contributing to, is not essential for its antiviral activity. Nonetheless, the structural and chemical properties of the N terminus of the ectodomain are important for optimal tethering function. This study provides detailed insight into the mechanisms by which this broad-spectrum antiviral restriction factor can function.

  4. Maps and Masses of Transiting Exoplanets: Towards New Insights into Atmospheric and Interior Properties of Planets

    E-Print Network [OSTI]

    de Wit, Julien

    2015-01-01

    With over 1800 planets discovered outside of the Solar System in the past two decades, the field of exoplanetology has broadened our perspective on planetary systems. Research priorities are now moving from planet detection to planet characterization. In this context, transiting exoplanets are of special interest due to the wealth of data made available by their orbital configuration. Here, I introduce two methods to gain new insights into the atmospheric and interior properties of exoplanets. The first method aims to map an exoplanet's atmosphere based on the scanning obtained while it is occulted by its host star. I introduce the basics of eclipse mapping, its caveats, and a framework to mitigate their effects via global analyses including transits, phase curves, and radial velocity measurements. I use this method to create the first 2D map and the first cloud map of an exoplanet for the hot-Jupiters HD189733b and Kepler-7b, respectively. Ultimately temperature, composition, and circulation patterns could b...

  5. Insights into the structure of mixed CO2/CH4 in gas hydrates

    SciTech Connect (OSTI)

    Everett, Susan M; Rawn, Claudia J; Chakoumakos, Bryan C; Keffer, David J.; Huq, Ashfia; Phelps, Tommy Joe

    2015-01-01

    The exchange of CO2 for CH4 in natural gas hydrates is an attractive approach to methane for energy production while simultaneously sequestering CO2. In addition to the energy and environmental implications, the solid solution of clathrate hydrate (CH4)1-x(CO2)x 5.75H2O provides a model system to study how the distinct bonding and shapes of CH4 and CO2 influence the structure and properties of the compound. High-resolution neutron diffraction was used to examine mixed CO2/CH4 gas hydrates. CO2-rich hydrates had smaller lattice parameters, which were attributed to the higher affinity of the CO2 molecule interacting with H2O molecules that form the surrounding cages, and resulted in a reduction in the unit cell volume. Experimental nuclear scattering densities illustrate how the cage occupants and energy landscape change with composition. These results provide important insights on the impact and mechanisms for exchanging CH4 and CO2.

  6. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Qiu, Wei; Lam, Robert; Voytyuk, Oleksandr; Romanov, Vladimir; Gordon, Roni; Gebremeskel, Simon; Vodsedalek, Jakub; Thompson, Christine; Beletskaya, Irina; Battaile, Kevin P.; et al

    2014-07-31

    The poly(ADP-ribose) polymerase (PARP) family represents a new class of therapeutic targets with diverse potential disease indications. PARP1 and PARP2 inhibitors have been developed for breast and ovarian tumors manifesting double-stranded DNA-repair defects, whereas tankyrase 1 and 2 (TNKS1 and TNKS2, also known as PARP5a and PARP5b, respectively) inhibitors have been developed for tumors with elevated ?-catenin activity. As the clinical relevance of PARP inhibitors continues to be actively explored, there is heightened interest in the design of selective inhibitors based on the detailed structural features of how small-molecule inhibitors bind to each of the PARP family members. Here, themore »high-resolution crystal structures of the human TNKS2 PARP domain in complex with 16 various PARP inhibitors are reported, including the compounds BSI-201, AZD-2281 and ABT-888, which are currently in Phase 2 or 3 clinical trials. These structures provide insight into the inhibitor-binding modes for the tankyrase PARP domain and valuable information to guide the rational design of future tankyrase-specific inhibitors.« less

  7. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2

    SciTech Connect (OSTI)

    Qiu, Wei; Lam, Robert; Voytyuk, Oleksandr; Romanov, Vladimir; Gordon, Roni; Gebremeskel, Simon; Vodsedalek, Jakub; Thompson, Christine; Beletskaya, Irina; Battaile, Kevin P.; Pai, Emil F.; Rottapel, Robert; Chirgadze, Nickolay Y.

    2014-07-31

    The poly(ADP-ribose) polymerase (PARP) family represents a new class of therapeutic targets with diverse potential disease indications. PARP1 and PARP2 inhibitors have been developed for breast and ovarian tumors manifesting double-stranded DNA-repair defects, whereas tankyrase 1 and 2 (TNKS1 and TNKS2, also known as PARP5a and PARP5b, respectively) inhibitors have been developed for tumors with elevated ?-catenin activity. As the clinical relevance of PARP inhibitors continues to be actively explored, there is heightened interest in the design of selective inhibitors based on the detailed structural features of how small-molecule inhibitors bind to each of the PARP family members. Here, the high-resolution crystal structures of the human TNKS2 PARP domain in complex with 16 various PARP inhibitors are reported, including the compounds BSI-201, AZD-2281 and ABT-888, which are currently in Phase 2 or 3 clinical trials. These structures provide insight into the inhibitor-binding modes for the tankyrase PARP domain and valuable information to guide the rational design of future tankyrase-specific inhibitors.

  8. Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

    SciTech Connect (OSTI)

    Sun, Jingchuan; Li, Huilin; Fernandez-Cid, Alejandra; Riera, Alberto; Tognetti, Sivia; Yuan, Zuanning; Stillman, Bruce; Speck, Christian

    2014-10-15

    Eukaryotic cells license each DNA replication origin during G1 phase by assembling a prereplication complex that contains a Mcm2–7 (minichromosome maintenance proteins 2–7) double hexamer. During S phase, each Mcm2–7 hexamer forms the core of a replicative DNA helicase. However, the mechanisms of origin licensing and helicase activation are poorly understood. The helicase loaders ORC–Cdc6 function to recruit a single Cdt1–Mcm2–7 heptamer to replication origins prior to Cdt1 release and ORC–Cdc6–Mcm2–7 complex formation, but how the second Mcm2–7 hexamer is recruited to promote double-hexamer formation is not well understood. Here, structural evidence for intermediates consisting of an ORC–Cdc6–Mcm2–7 complex and an ORC–Cdc6–Mcm2–7–Mcm2–7 complex are reported, which together provide new insights into DNA licensing. Detailed structural analysis of the loaded Mcm2–7 double-hexamer complex demonstrates that the two hexamers are interlocked and misaligned along the DNA axis and lack ATP hydrolysis activity that is essential for DNA helicase activity. Moreover, we show that the head-to-head juxtaposition of the Mcm2–7 double hexamer generates a new protein interaction surface that creates a multisubunit-binding site for an S-phase protein kinase that is known to activate DNA replication. The data suggest how the double hexamer is assembled and how helicase activity is regulated during DNA licensing, with implications for cell cycle control of DNA replication and genome stability.

  9. ROBUSTNESS OF DECISION INSIGHTS UNDER ALTERNATIVE ALEATORY/EPISTEMIC UNCERTAINTY CLASSIFICATIONS

    SciTech Connect (OSTI)

    Unwin, Stephen D.; Eslinger, Paul W.; Johnson, Kenneth I.

    2013-09-22

    The Risk-Informed Safety Margin Characterization (RISMC) pathway is a set of activities defined under the U.S. Department of Energy Light Water Reactor Sustainability Program. The overarching objective of RISMC is to support plant life-extension decision-making by providing a state-of-knowledge characterization of safety margins in key systems, structures, and components (SSCs). A key technical challenge is to establish the conceptual and technical feasibility of analyzing safety margin in a risk-informed way, which, unlike conventionally defined deterministic margin analysis, would be founded on probabilistic characterizations of SSC performance. Evaluation of probabilistic safety margins will in general entail the uncertainty characterization both of the prospective challenge to the performance of an SSC ("load") and of its "capacity" to withstand that challenge. The RISMC framework contrasts sharply with the traditional probabilistic risk assessment (PRA) structure in that the underlying models are not inherently aleatory. Rather, they are largely deterministic physical/engineering models with ambiguities about the appropriate uncertainty classification of many model parameters. The current analysis demonstrates that if the distinction between epistemic and aleatory uncertainties is to be preserved in a RISMC-like modeling environment, then it is unlikely that analysis insights supporting decision-making will in general be robust under recategorization of input uncertainties. If it is believed there is a true conceptual distinction between epistemic and aleatory uncertainty (as opposed to the distinction being primarily a legacy of the PRA paradigm) then a consistent and defensible basis must be established by which to categorize input uncertainties.

  10. Galaxy Evolution Insights from Spectral Modeling of Large Data Sets from the Sloan Digital Sky Survey

    SciTech Connect (OSTI)

    Hoversten, Erik A.; /Johns Hopkins U.

    2007-10-01

    This thesis centers on the use of spectral modeling techniques on data from the Sloan Digital Sky Survey (SDSS) to gain new insights into current questions in galaxy evolution. The SDSS provides a large, uniform, high quality data set which can be exploited in a number of ways. One avenue pursued here is to use the large sample size to measure precisely the mean properties of galaxies of increasingly narrow parameter ranges. The other route taken is to look for rare objects which open up for exploration new areas in galaxy parameter space. The crux of this thesis is revisiting the classical Kennicutt method for inferring the stellar initial mass function (IMF) from the integrated light properties of galaxies. A large data set ({approx} 10{sup 5} galaxies) from the SDSS DR4 is combined with more in-depth modeling and quantitative statistical analysis to search for systematic IMF variations as a function of galaxy luminosity. Galaxy H{alpha} equivalent widths are compared to a broadband color index to constrain the IMF. It is found that for the sample as a whole the best fitting IMF power law slope above 0.5 M{sub {circle_dot}} is {Lambda} = 1.5 {+-} 0.1 with the error dominated by systematics. Galaxies brighter than around M{sub r,0.1} = -20 (including galaxies like the Milky Way which has M{sub r,0.1} {approx} -21) are well fit by a universal {Lambda} {approx} 1.4 IMF, similar to the classical Salpeter slope, and smooth, exponential star formation histories (SFH). Fainter galaxies prefer steeper IMFs and the quality of the fits reveal that for these galaxies a universal IMF with smooth SFHs is actually a poor assumption. Related projects are also pursued. A targeted photometric search is conducted for strongly lensed Lyman break galaxies (LBG) similar to MS1512-cB58. The evolution of the photometric selection technique is described as are the results of spectroscopic follow-up of the best targets. The serendipitous discovery of two interesting blue compact dwarf galaxies is reported. These galaxies were identified by their extremely weak (< 150) [N {pi}] {lambda}6584 to H{alpha} emission line ratios. Abundance analysis from emission line fluxes reveals that these galaxies have gas phase oxygen abundances 12 + log(O/H) {approx} 7.7 to 7.9, not remarkably low, and near infrared imaging detects an old stellar population. However, the measured nitrogen to oxygen ratios log(N/O) < 1.7 are anomalously low for blue compact dwarf galaxies. These objects may be useful for understanding the chemical evolution of nitrogen.

  11. On the origin of the Hubble sequence: I. Insights on galaxy color migration from cosmological simulations

    SciTech Connect (OSTI)

    Cen, Renyue

    2014-01-20

    An analysis of more than 3000 galaxies resolved at better than 114 h{sup –1} pc at z = 0.62 in a 'LAOZI' cosmological adaptive mesh refinement hydrodynamic simulation is performed and insights are gained on star formation quenching and color migration. The vast majority of red galaxies are found to be within three virial radii of a larger galaxy at the onset of quenching, when the specific star formation rate experiences the sharpest decline to fall below ?10{sup –2}-10{sup –1} Gyr{sup –1} (depending on the redshift). Thus, we shall call this mechanism 'environment quenching', which encompasses satellite quenching. Two physical processes are largely responsible: Ram pressure stripping first disconnects the galaxy from the cold gas supply on large scales, followed by a longer period of cold gas starvation taking place in a high velocity-dispersion environment, in which during the early part of the process, the existing dense cold gas in the central region (?10 kpc) is consumed by in situ star formation. On average, quenching is found to be more efficient (i.e., a larger fraction of galaxies being quenched) but not faster (i.e., the duration being weakly dependent on the environment) in a denser environment. Throughout this quenching period and the ensuing one in the red sequence, galaxies follow nearly vertical tracks in the color-stellar mass diagram. In contrast, individual galaxies of all masses grow most of their stellar masses in the blue cloud, prior to the onset of quenching, and progressively more massive blue galaxies with already relatively older mean stellar ages continue to enter the red sequence. Consequently, correlations among observables of red galaxies—such as the age-mass relation— are largely inherited from their blue progenitors at the onset of quenching. While the color makeup of the entire galaxy population strongly depends on the environment, which is a direct result of environment quenching, physical properties of blue galaxies as a subpopulation show little dependence on the environment. A variety of predictions from the simulation are shown to be in accordance with extant observations.

  12. Circadian rhythms in Synechococcus elongatus PCC 7942: insights into the regulatory mechanisms of the cyanobacterial clock system 

    E-Print Network [OSTI]

    Mackey, Shannon Rose

    2009-06-02

    stream_source_info MACKEY-DISSERTATION.pdf.txt stream_content_type text/plain stream_size 269156 Content-Encoding ISO-8859-1 stream_name MACKEY-DISSERTATION.pdf.txt Content-Type text/plain; charset=ISO-8859-1 CIRCADIAN... RHYTHMS IN Synechococcus elongatus PCC 7942: INSIGHTS INTO THE REGULATORY MECHANISMS OF THE CYANOBACTERIAL CLOCK SYSTEM A Dissertation by SHANNON ROSE MACKEY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

  13. A Carbon Flux Super Site. New Insights and Innovative Atmosphere-Terrestrial Carbon Exchange Measurements and Modeling

    SciTech Connect (OSTI)

    Leclerc, Monique Y.

    2014-11-17

    This final report presents the main activities and results of the project “A Carbon Flux Super Site: New Insights and Innovative Atmosphere-Terrestrial Carbon Exchange Measurements and Modeling” from 10/1/2006 to 9/30/2014. It describes the new AmeriFlux tower site (Aiken) at Savanna River Site (SC) and instrumentation, long term eddy-covariance, sodar, microbarograph, soil and other measurements at the site, and intensive field campaigns of tracer experiment at the Carbon Flux Super Site, SC, in 2009 and at ARM-CF site, Lamont, OK, and experiments in Plains, GA. The main results on tracer experiment and modeling, on low-level jet characteristics and their impact on fluxes, on gravity waves and their influence on eddy fluxes, and other results are briefly described in the report.

  14. Efficient and Reliable Reactive Power Supply and Consumption --Insights from an Integrated Program of Engineering and EconomicResearch

    SciTech Connect (OSTI)

    Thomas, Robert J.; Mount, Timothy D.; Schuler, Richard; Schulze,William; Zimmerman, Ray; Alvarado, Fernando; Lesieutre, Bernard C.; Overholt, Philip N.; Eto, Joseph H.

    2008-01-01

    In 2005, the Federal Energy Regulatory Commission (FERC) began discussing regulatory policy for reactive-power procurement and pricing in competitive electricity markets. This paper summarizes findings from a unique, interdisciplinary program of public-interest research that lays a formal foundation for evaluating aspects of FERC staff recommendations and offers early insights that should be useful in guiding policy implementation, specifically by: (1) clarifying the consumers and economic characteristics of reactive power as a basis for creating incentives to appropriately price it, (2) defining specific challenges in creating a competitive market for reactive power as well as new tools needed to help ensure such a market functions efficiently, and (3) demonstrating the importance of accounting for the physical characteristics of the transmission network in planning for reactive power and avoiding the exercise of market power by suppliers.

  15. Insights into Structure and Stratigraphy of the Northern Gulf of Mexico from 2D Pre-Stack Depth Migration Imaging of

    E-Print Network [OSTI]

    Connors, Christopher D.

    Insights into Structure and Stratigraphy of the Northern Gulf of Mexico from 2D Pre-Stack Depth of Mexico because the onshore shelf margins and linked deep water systems can be seen in continuous sec water of the northwestern Gulf of Mexico and displays distinct, large-scale structural styles and salt

  16. Insights from the Nogales Predator Crash for the Integration of UAV's into the US National Airspace System under FAA Interim Operational Approval Guidance 08-01

    E-Print Network [OSTI]

    Johnson, Chris

    Insights from the Nogales Predator Crash for the Integration of UAV's into the US National Airspace Traffic Management. Abstract In April 2006, an Unmanned Aerial Vehicle (UAV) crashed near Nogales, Arizona whether a process that enables the same agency to act as regulator and operator of a UAV can be justified

  17. Genomewide analysis of polysaccharides degrading enzymes in 11 white-and brown-rot Polyporales provides insight into mechanisms of wood decay

    E-Print Network [OSTI]

    Hibbett, David S.

    provides insight into mechanisms of wood decay Chiaki Hori Department of Biomaterials Sciences, Graduate, Wisconsin 53726 Abstract: To degrade the polysaccharides, wood- decay fungi secrete a variety of glycoside brevispora. Furthermore, we conducted comparative secretome analysis of seven Polyporales grown on wood

  18. Does extrusion occur at both tips of the Taiwan collision belt? Insights from active deformation studies in the Ilan Plain and Pingtung Plain regions

    E-Print Network [OSTI]

    Lee, Jian-Cheng

    Does extrusion occur at both tips of the Taiwan collision belt? Insights from active deformation Institut Universitaire de France France c Institute of Applied Geosciences, National Taiwan Ocean University, Keelung, Taiwan, ROC d Institute of Oceanography, National Taiwan University, Taipei, Taiwan, ROC

  19. Elevated CO2 increases tree-level intrinsic water use efficiency: insights from carbon and oxygen isotope analyses in tree rings

    E-Print Network [OSTI]

    - see, USA) sites, to cover the entire life of the trees. We used d13 C to assess carbon isotopeElevated CO2 increases tree-level intrinsic water use efficiency: insights from carbon and oxygen intrinsic water use efficiency (WUEi) of forests, but the magnitude of this effect and its interaction

  20. Structural, functional and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Pratt, Ashley J.; DiDonato, Michael; Shin, David S.; Cabelli, Diane E.; Bruns, Cami K.; Belzer, Carol A.; Gorringe, Andrew R.; Langford, Paul R.; Tabatabai, Louisa B.; Kroll, J. Simon; et al

    2015-10-12

    Bacterial pathogens Neisseria meningitidis and Brucella abortus pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute N. meningitidis infections remains high despite antibiotics, and brucellosis presents alimentary and health consequences. Superoxide dismutases are master regulators of reactive oxygen, general pathogenicity factors and therefore therapeutic targets. Cu,Zn superoxide dismutases (SODs) localized to the periplasm promote survival by detoxifying superoxide radicals generated by major host antimicrobial immune responses. We discovered that passive immunization with an antibody directed at N. meningitidis SOD (NmSOD) was protective in a mouse infection model. To define the relevant atomicmore »details and solution assembly states of this important virulence factor, we report high-resolution and X-ray scattering analyses of NmSOD and SOD from B. abortus (BaSOD). The NmSOD structures revealed an auxiliary tetrahedral Cu-binding site bridging the dimer interface; mutational analyses suggested that this metal site contributes to protein stability, with implications for bacterial defense mechanisms. Biochemical and structural analyses informed us about electrostatic substrate guidance, dimer assembly and an exposed C-terminal epitope in the NmSOD dimer. In contrast, the monomeric BaSOD structure provided insights for extending immunogenic peptide epitopes derived from the protein. These collective results reveal unique contributions of SOD to pathogenic virulence, refine predictive motifs for distinguishing SOD classes and suggest general targets for anti-bacterial immune responses. The identified functional contributions, motifs, and targets distinguishing bacterial and eukaryotic SOD assemblies presented here provide a foundation for efforts to develop SOD-specific inhibitors or vaccines against these harmful pathogens. IMPORTANCE By protecting microbes against reactive oxygen insults, Cu,Zn superoxide dismutases (SODs) aid survival of many bacteria within their hosts. Despite the ubiquity and conservation of these key enzymes, notable species-specific differences relevant to pathogenesis remain undefined. To probe mechanisms that govern the functioning of Neisseria meningitidis and Brucella abortus SODs, we used X-ray structures, enzymology, modeling and murine infection experiments. We identified virulence determinants common to both homologs, assembly differences and a unique metal reservoir within meningococcal SOD that stabilizes the enzyme and may provide a safeguard against copper toxicity. The insights reported here provide a rationale and basis for SOD-specific drugs and extension of immunogen design to target two important pathogens that continue to pose global health threats.« less

  1. Aerosol retention during SGTR meltdown sequences: Experimental insights of the effect of size and shape of the breach

    SciTech Connect (OSTI)

    Herranz, L. E.; Tardaguila, R. D.; Lopez, C. [Unit of Nuclear Safety Research, CIEMAT, Avd. Complutense, 22, 28040 Madrid (Spain)

    2012-07-01

    This paper summarizes the major insights gained from aerosol retention capability of a tube bundle that simulates the break stage of the secondary side of a failed steam generator under dry SGTR conditions. This scenario is highly relevant in nuclear safety since it affects the potential retention of radioactive particles in case of meltdown sequences with a SGTR. An 8-test experimental campaign has been carried out, extending the current database on the decontamination capability of the steam generator. The effects of the breach features (shape and size) and the particle nature (SiO{sub 2} and TiO{sub 2}) on the collection efficiency have been explored. The results confirmed the strong effect of the physical nature even when tube breaks in a fish-mouth mode. Loose aggregates (i.e. TiO{sub 2}) would be trapped to a limited extent (less than 25%); while single- or few-aggregates (i.e. SiO{sub 2}) would undergo a quite effective removal (i.e. over 75%). For fish-mouth breaches and SiO{sub 2} particles, the breach size has been found to moderately affect retention efficiency. Furthermore, the breach shape does not seem to have any effect on the net collection efficiency within the break stage, no matter the particle type. However, individual tube measurements indicate notably different deposition patterns, although an effect of the facility geometry cannot be disregarded as a key player in this observation. (authors)

  2. Nuclear Safety Design Principles & the Concept of Independence: Insights from Nuclear Weapon Safety for Other High-Consequence Applications.

    SciTech Connect (OSTI)

    Brewer, Jeffrey D.

    2014-05-01

    Insights developed within the U.S. nuclear weapon system safety community may benefit system safety design, assessment, and management activities in other high consequence domains. The approach of assured nuclear weapon safety has been developed that uses the Nuclear Safety Design Principles (NSDPs) of incompatibility, isolation, and inoperability to design safety features, organized into subsystems such that each subsystem contributes to safe system responses in independent and predictable ways given a wide range of environmental contexts. The central aim of the approach is to provide a robust technical basis for asserting that a system can meet quantitative safety requirements in the widest context of possible adverse or accident environments, while using the most concise arrangement of safety design features and the fewest number of specific adverse or accident environment assumptions. Rigor in understanding and applying the concept of independence is crucial for the success of the approach. This paper provides a basic description of the assured nuclear weapon safety approach, in a manner that illustrates potential application to other domains. There is also a strong emphasis on describing the process for developing a defensible technical basis for the independence assertions between integrated safety subsystems.

  3. Insights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1

    SciTech Connect (OSTI)

    Liu,Q.; Hendrickson, W.

    2007-01-01

    Classic Hsp70 chaperones assist in diverse processes of protein folding and translocation, and Hsp110s had seemed by sequence to be distant relatives within an Hsp70 superfamily. The 2.4 Angstroms resolution structure of Sse1 with ATP shows that Hsp110s are indeed Hsp70 relatives, and it provides insight into allosteric coupling between sites for ATP and polypeptide-substrate binding in Hsp70s. Subdomain structures are similar in intact Sse1(ATP) and in the separate Hsp70 domains, but conformational dispositions are radically different. Interfaces between Sse1 domains are extensive, intimate, and conservative in sequence with Hsp70s. We propose that Sse1(ATP) may be an evolutionary vestige of the Hsp70(ATP) state, and an analysis of 64 mutant variants in Sse1 and three Hsp70 homologs supports this hypothesis. An atomic-level understanding of Hsp70 communication between ATP and substrate-binding domains follows. Requirements on Sse1 for yeast viability are in keeping with the distinct function of Hsp110s as nucleotide exchange factors.

  4. Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

    SciTech Connect (OSTI)

    Brewer, Jeffrey D.

    2005-11-01

    The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.

  5. Insights into Regulated Ligand Binding Sites from the Structure of ZO-1 Src Homology 3-Guanylate Kinase Module

    SciTech Connect (OSTI)

    Lye, Ming F.; Fanning, Alan S.; Su, Ying; Anderson, James M.; Lavie, Arnon (UNC); (UIC)

    2010-11-09

    Tight junctions are dynamic components of epithelial and endothelial cells that regulate the paracellular transport of ions, solutes, and immune cells. The assembly and permeability of these junctions is dependent on the zonula occludens (ZO) proteins, members of the membrane-associated guanylate kinase homolog (MAGUK) protein family, which are characterized by a core Src homology 3 (SH3)-GUK module that coordinates multiple protein-protein interactions. The structure of the ZO-1 SH3-GUK domain confirms that the interdependent folding of the SH3 and GUK domains is a conserved feature of MAGUKs, but differences in the orientation of the GUK domains in three different MAGUKs reveal interdomain flexibility of the core unit. Using pull-down assays, we show that an effector loop, the U6 region in ZO-1, forms a novel intramolecular interaction with the core module. This interaction is divalent cation-dependent and overlaps with the binding site for the regulatory molecule calmodulin on the GUK domain. These findings provide insight into the previously observed ability of the U6 region to regulate TJ assembly in vivo and the structural basis for the complex protein interactions of the MAGUK family.

  6. Reexamination of the mean-field phase diagram of biaxial nematic liquid crystals: Insights from Monte Carlo studies

    E-Print Network [OSTI]

    B. Kamala Latha; Regina Jose; K. P. N. Murthy; V. S. S. Sastry

    2015-09-13

    Investigations of the phase diagram of biaxial liquid crystal systems through analyses of general Hamiltonian models within the simplifications of mean-field theory (MFT), as well as by computer simulations based on microscopic models, are directed towards an appreciation of the role of the underlying molecular-level interactions to facilitate its spontaneous condensation into a nematic phase with biaxial symmetry. Continuing experimental challenges in realising such a system unambiguously, despite encouraging predictions from MFT for example, are requiring more versatile simulational methodologies capable of providing insights into possible hindering barriers within the system, typically gleaned through its free energy dependences on relevant observables as the system is driven through the transitions. The recent brief report from this group [B. Kamala Latha, et. al., Phys. Rev. E 89, 050501 (R), 2014] summarizing the outcome of detailed Monte Carlo simulations carried out employing entropic sampling technique, suggested a qualitative modification of the MFT phase diagram as the Hamiltonian is asymptotically driven towards the so-called partly-repulsive regions. It was argued that the degree of the (cross) coupling between the uniaxial and biaxial tensor components of neighbouring molecules plays a crucial role in facilitating, or otherwise, a ready condensation of the biaxial phase, suggesting that this could be a plausible f actor in explaining the experimental difficulties. In this paper, we elaborate this point further, providing additional evidences from curious variations of free-energy profiles with respect to the relevant orientational order parameters, at different temperatures bracketing the phase transitions.

  7. Insights into the structure–photoreactivity relationships in well-defined perovskite ferroelectric KNbO 3 nanowires

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhang, Tingting; Lei, Wanying; Liu, Ping; Rodriguez, José A.; Yu, Jiaguo; Qi, Yang; Liu, Gang; Liu, Minghua

    2015-04-23

    Structure–function correlations are a central theme in heterogeneous (photo)catalysis. In this study, the geometric and electronic structure of perovskite ferroelectric KNbO3 nanowires with respective orthorhombic and monoclinic polymorphs have been systematically addressed. By virtue of aberration-corrected scanning transmission electron microscopy, we directly visualize surface photocatalytic active sites, measure local atomic displacements at an accuracy of several picometers, and quantify ferroelectric polarization combined with first-principles calculations. The photoreactivity of the as-prepared KNbO3 nanowires is assessed toward aqueous rhodamine B degradation under UV light. A synergy between the ferroelectric polarization and electronic structure in photoreactivity enhancement is uncovered, which accounts for themore »prominent reactivity order: orthorhombic > monoclinic. Additionally, by identifying new photocatalytic products, rhodamine B degradation pathways involving N-deethylation and conjugated structure cleavage are proposed. The findings not only provide new insights into the structure–photoreactivity relationships in perovskite ferroelectric photocatalysts, but also have broad implications in perovskite-based water splitting and photovoltaics, among others.« less

  8. Multi-scale Detection of Organic and Inorganic Signatures Provides Insights into Gas Shale Properties and Evolution

    SciTech Connect (OSTI)

    Bernard, S.; Horsfield, B; Schultz, H; Schreiber, A; Wirth, R; Thi AnhVu, T; Perssen, F; Konitzer, S; Volk, H; et. al.

    2010-01-01

    Organic geochemical analyses, including solvent extraction or pyrolysis, followed by gas chromatography and mass spectrometry, are generally conducted on bulk gas shale samples to evaluate their source and reservoir properties. While organic petrology has been directed at unravelling the matrix composition and textures of these economically important unconventional resources, their spatial variability in chemistry and structure is still poorly documented at the sub-micrometre scale. Here, a combination of techniques including transmission electron microscopy and a synchrotron-based microscopy tool, scanning transmission X-ray microscopy, have been used to characterize at a multiple length scale an overmature organic-rich calcareous mudstone from northern Germany. We document multi-scale chemical and mineralogical heterogeneities within the sample, from the millimetre down to the nanometre-scale. From the detection of different types of bitumen and authigenic minerals associated with the organic matter, we show that the multi-scale approach used in this study may provide new insights into gaseous hydrocarbon generation/retention processes occurring within gas shales and may shed new light on their thermal history.

  9. Revisiting Insights from Three Mile Island Unit 2 Postaccident Examinations and Evaluations in View of the Fukushima Daiichi Accident

    SciTech Connect (OSTI)

    Joy Rempe; Mitchell Farmer; Michael Corradini; Larry Ott; Randall Gauntt; Dana Powers

    2012-11-01

    The Three Mile Island Unit 2 (TMI-2) accident, which occurred on March 28, 1979, led industry and regulators to enhance strategies to protect against severe accidents in commercial nuclear power plants. Investigations in the years after the accident concluded that at least 45% of the core had melted and that nearly 19 tonnes of the core material had relocated to the lower head. Postaccident examinations indicate that about half of that material formed a solid layer near the lower head and above it was a layer of fragmented rubble. As discussed in this paper, numerous insights related to pressurized water reactor accident progression were gained from postaccident evaluations of debris, reactor pressure vessel (RPV) specimens, and nozzles taken from the RPV. In addition, information gleaned from TMI-2 specimen evaluations and available data from plant instrumentation were used to improve severe accident simulation models that form the technical basis for reactor safety evaluations. Finally, the TMI-2 accident led the nuclear community to dedicate considerable effort toward understanding severe accident phenomenology as well as the potential for containment failure. Because available data suggest that significant amounts of fuel heated to temperatures near melting, the events at Fukushima Daiichi Units 1, 2, and 3 offer an unexpected opportunity to gain similar understanding about boiling water reactor accident progression. To increase the international benefit from such an endeavor, we recommend that an international effort be initiated to (a) prioritize data needs; (b) identify techniques, samples, and sample evaluations needed to address each information need; and (c) help finance acquisition of the required data and conduct of the analyses.

  10. UNCORRECTED Molecular Insights into

    E-Print Network [OSTI]

    Hay, Bruce A.

    Mutations on aSyn Self-assembly........................... 4 C. Modulation of aSyn Aggregation by Long of Posttranslational Modifications on aSyn Self-assembly and Neurotoxicity............................................................................. 7 F. Effects of Phospholipids on aSyn Self-assembly................................. 14 G

  11. Insight From Efficiency Maine

    Broader source: Energy.gov [DOE]

    Presents an in-depth look at Efficiency Maine's transition to weatherization financing, its PowerSaver program, and much more.

  12. Insights into Chemical Reactivity /

    E-Print Network [OSTI]

    Burke, Kathryn D.

    2013-01-01

    224 Table A-4. Optimized Cartesian coordinates (Å) of224 Table A-5. Optimized Cartesian coordinates (Å) of225 Table A-6. Optimized Cartesian coordinates (Å) of ketene

  13. Base isolation: Fresh insight

    SciTech Connect (OSTI)

    Shustov, V.

    1993-07-15

    The objective of the research is a further development of the engineering concept of seismic isolation. Neglecting the transient stage of seismic loading results in a widespread misjudgement: The force of resistance associated with velocity is mostly conceived as a source of damping vibrations, though it is an active force at the same time, during an earthquake type excitation. For very pliant systems such as base isolated structures with relatively low bearing stiffness and with artificially added heavy damping mechanism, the so called `damping`` force may occur even the main pushing force at an earthquake. Thus, one of the two basic pillars of the common seismic isolation philosophy, namely, the doctrine of usefulness and necessity of a strong damping mechanism, is turning out to be a self-deception, sometimes even jeopardizing the safety of structures and discrediting the very idea of seismic isolation. There is a way out: breaking with damping dependancy.

  14. CUISINE AND INSIGHTS ON

    E-Print Network [OSTI]

    Liley, David

    Offset Alpine PORTRAIT PHOTOGRAPHY Eamon Gallagher COVER Corbis Images Printed on PEFC Certified paper

  15. Global Insight Energy Group

    Gasoline and Diesel Fuel Update (EIA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustments (Billion Cubic Feet) Wyoming Dry NaturalPrices1Markets See full Genealogy of Major U.S.GasOutlook

  16. Thermochemical Insight into the Reduction of CO to CH3OH with [Re(CO)]+ and [Mn(CO)]+ Complexes

    SciTech Connect (OSTI)

    Wiedner, Eric S.; Appel, Aaron M.

    2014-05-22

    To gain insight into thermodynamic barriers for reduction of CO into CH3OH, free energies for reduction of [CpRe(PPh3)(NO)(CO)]+ into CpRe(PPh3)(NO)(CH2OH) have been determined from experimental measurements. Using model complexes, the free energies for the transfer of H+, H–, and e– have been determined. A pKa of 10.6 was estimated for [CpRe(PPh3)(NO)(CHOH)]+ by measuring the pKa for the analogous [CpRe(PPh3)(NO)(CMeOH)]+. The hydride donor ability (?G°H–) of CpRe(PPh3)(NO)(CH2OH) was estimated to be 58.0 kcal mol–1, based on calorimetry measurements of the hydride transfer reaction between CpRe(PPh3)(NO)(CHO) and [CpRe(PPh3)(NO)(CHOMe)]+ to generate the methylated analog, CpRe(PPh3)(NO)(CH2OMe). Cyclic voltammograms recorded on CpRe(PPh3)(NO)(CMeO), CpRe(PPh3)(NO)(CH2OMe), and [CpRe(PPh3)(NO)(CHOMe)]+ displayed either a quasireversible oxidation (neutral species) or reduction (cationic species). These potentials were used as estimates for the oxidation of CpRe(PPh3)(NO)(CHO) or CpRe(PPh3)(NO)(CH2OH), or the reduction of [CpRe(PPh3)(NO)(CHOH)]+. Combination of the thermodynamic data permits construction of three-dimensional free energy landscapes under varying conditions of pH and PH2. The free energy for H2 addition (?G°H2) to [CpRe(PPh3)(NO)(CO)]+ (+15 kcal mol–1) was identified as the most significant thermodynamic impediment for the reduction of CO. DFT computations indicate that ?G°H2 varies by only 4.3 kcal mol–1 across a series of [CpXRe(L)(NO)(CO)]+, while the experimental ?G°H– values for the analogous series of CpRe(PPh3)(NO)(CHO) varies by 12.9 kcal mol–1. The small range of ?G°H2 values is attributed to a minimal change in the C–O bond polarization upon modification of the ancillary ligands, as determined from the computed atomic charges. This work was supported by the US Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences & Biosciences. Pacific Northwest National Laboratory (PNNL) is a multiprogram national laboratory operated for DOE by Battelle.

  17. Systems level insights into alternate methane cycling modes in a freshwater lake via community transcriptomics, metabolomics and nano-SIMS analysis

    SciTech Connect (OSTI)

    Lidstrom, Mary E.; Chistoserdova, Ludmila; Kalyuzhnaya, Marina G.; Orphan, Victoria J.; Beck, David A.

    2014-08-07

    The research conducted as part of this project contributes significantly to the understanding of the microbes and their activities involved in methane metabolism in freshwater lake sediments and in the environment in a more global sense. Significant new insights have been gained into the identity of the species that are most active in methane oxidation. New concepts have been developed based on the new data on how these organisms metabolize methane, impacting not only environmental microbiology but also biotechnology, including biotechnology of next generation biofuels. Novel approaches have been developed for studying functional microbial communities, via holistic approaches, such as metagenomics, metatrancriptomics and metabolite analysis. As a result, a novel outlook has been obtained at how such communities operate in nature. Understanding methane-oxidizing communities in lakes and other environments is of significant benefit to the public, in terms of methane emission mitigation and in terms of potential biotechnological applications.

  18. The GC-Rich Mitochondrial and Plastid Genomes of the Green Alga Coccomyxa Give Insight into the Evolution of Organelle DNA Nucleotide Landscape

    SciTech Connect (OSTI)

    Smith, David Roy; Burki, Fabien; Yamada, Takashi; Grimwood, Jane; Grigoriev, Igor V.; Van Etten, James L.; Keeling, Patrick J.

    2011-05-13

    Most of the available mitochondrial and plastid genome sequences are biased towards adenine and thymine (AT) over guanine and cytosine (GC). Examples of GC-rich organelle DNAs are limited to a small but eclectic list of species, including certain green algae. Here, to gain insight in the evolution of organelle nucleotide landscape, we present the GC-rich mitochondrial and plastid DNAs from the trebouxiophyte green alga Coccomyxa sp. C-169. We compare these sequences with other GC-rich organelle DNAs and argue that the forces biasing them towards G and C are nonadaptive and linked to the metabolic and/or life history features of this species. The Coccomyxa organelle genomes are also used for phylogenetic analyses, which highlight the complexities in trying to resolve the interrelationships among the core chlorophyte green algae, but ultimately favour a sister relationship between the Ulvophyceae and Chlorophyceae, with the Trebouxiophyceae branching at the base of the chlorophyte crown.

  19. Theoretical Insight into the Interactions of TMA-Benzene and TMA-Pyrrole with B3LYP Density-Functional Theory (DFT) and ab Initio Second Order Mller-Plesset Perturbation

    E-Print Network [OSTI]

    Sussman, Joel L.

    Theoretical Insight into the Interactions of TMA-Benzene and TMA-Pyrrole with B3LYP Density theoretical investigation of the tetramethylammonium(TMA)-benzene and TMA-pyrrole complexes has been performed density in the 5 6 aromatic system of pyrrole is larger than that in the 6 6 system of benzene

  20. Ertek, G., Tun, M.M., Kurtaraner, E., Kebude, D., 2012, 'Insights into the Efficiencies of On-Shore Wind Turbines: A Data-Centric Analysis', INISTA 2012 Conference. July 2-4, 2012, Trabzon,

    E-Print Network [OSTI]

    Yanikoglu, Berrin

    -Shore Wind Turbines: A Data-Centric Analysis', INISTA 2012 Conference. July 2-4, 2012, Trabzon, Turkey://research.sabanciuniv.edu. Insights into the Efficiencies of On-Shore Wind Turbines: A Data-Centric Analysis Gürdal Ertek, Murat University Istanbul, Turkey Abstract--Literature on renewable energy alternative of wind turbines does

  1. Mechanistic insights of ethanol steam reforming over Ni-CeOx(111): The importance of hydroxyl groups for suppressing coke formation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Liu, Zongyuan; Senanayake, Sanjaya D.; Duchon, Tomas; Wang, Huanru; Peterson, Erik W.; Zhou, Yinghui; Luo, Si; Zhou, Jing; Matolin, Vladimir; Stacchiola, Dario J.; et al

    2015-07-10

    We have studied the reaction of ethanol and water over Ni–CeO2-x(111) model surfaces to elucidate the mechanistic steps associated with the ethanol steam reforming (ESR) reaction. Our results provide insights about the importance of hydroxyl groups to the ESR reaction over Ni-based catalysts. Systematically, we have investigated the reaction of ethanol on Ni–CeO2-x(111) at varying Ce³? concentrations (CeO1.8–2.0) with absence/presence of water using a combination of soft X-ray photoelectron spectroscopy (sXPS) and temperature-programmed desorption (TPD). Consistent with previous reports, upon annealing, metallic Ni formed on reduced ceria while NiO was the main component on fully oxidized ceria. Ni? is themore »active phase leading to both the C–C and C–H cleavage of ethanol but is also responsible for carbon accumulation or coking. We have identified a Ni?C phase that formed prior to the formation of coke. At temperatures above 600K, the lattice oxygen from ceria and the hydroxyl groups from water interact cooperatively in the removal of coke, likely through a strong metal–support interaction between nickel and ceria that facilitates oxygen transfer.« less

  2. Mechanistic Insights of Ethanol Steam Reforming over Ni–CeO x (111): The Importance of Hydroxyl Groups for Suppressing Coke Formation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Liu, Zongyuan; Ducho?, Tomáš; Wang, Huanru; Peterson, Erik W.; Zhou, Yinghui; Luo, Si; Zhou, Jing; Matolín, Vladimir; Stacchiola, Dario J.; Rodriguez, José A.; et al

    2015-07-30

    We have studied the reaction of ethanol and water over Ni–CeO2-x(111) model surfaces to elucidate the mechanistic steps associated with the ethanol steam reforming (ESR) reaction. Our results provide insights about the importance of hydroxyl groups to the ESR reaction over Ni-based catalysts. Systematically, we have investigated the reaction of ethanol on Ni–CeO2-x(111) at varying Ce³? concentrations (CeO1.8–2.0) with absence/presence of water using a combination of soft X-ray photoelectron spectroscopy (sXPS) and temperature-programmed desorption (TPD). Consistent with previous reports, upon annealing, metallic Ni formed on reduced ceria while NiO was the main component on fully oxidized ceria. Ni? is themore »active phase leading to both the C–C and C–H cleavage of ethanol but is also responsible for carbon accumulation or coking. We have identified a Ni?C phase that formed prior to the formation of coke. At temperatures above 600K, the lattice oxygen from ceria and the hydroxyl groups from water interact cooperatively in the removal of coke, likely through a strong metal–support interaction between nickel and ceria that facilitates oxygen transfer.« less

  3. Insights from investigating the interactions of adamantane-based drugs with the M2 proton channel from the H1N1 swine virus

    SciTech Connect (OSTI)

    Wang, Jing-Fang [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China)] [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China); Wei, Dong-Qing, E-mail: dqwei@gordonlifescience.org [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China) [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China); Gordon Life Science Institute, 13784 Torrey Del Mar Drive, San Diego, CA 92130 (United States); Chou, Kuo-Chen [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China) [College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240 (China); Gordon Life Science Institute, 13784 Torrey Del Mar Drive, San Diego, CA 92130 (United States)

    2009-10-16

    The M2 proton channel is one of indispensable components for the influenza A virus that plays a vital role in its life cycle and hence is an important target for drug design against the virus. In view of this, the three-dimensional structure of the H1N1-M2 channel was developed based on the primary sequence taken from a patient recently infected by the H1N1 (swine flu) virus. With an explicit water-membrane environment, molecular docking studies were performed for amantadine and rimantadine, the two commercial drugs generally used to treat influenza A infection. It was found that their binding affinity to the H1N1-M2 channel is significantly lower than that to the H5N1-M2 channel, fully consistent with the recent report that the H1N1 swine virus was resistant to the two drugs. The findings and the relevant analysis reported here might provide useful structural insights for developing effective drugs against the new swine flu virus.

  4. QUT Digital Repository: http://eprints.qut.edu.au/

    E-Print Network [OSTI]

    Liang, Huizhi "Elly"

    process models driven by industry consortia, such as SCOR1 , VICS2 or ITIL3 , go a long way Inter-industry Commerce Solutions: www.vics.org 3 Information Technology Infrastructure Library: www.itil

  5. Structural and organizational changes of the housebuilding industry in the United States and Japan

    E-Print Network [OSTI]

    Minami, Kazunobu

    1986-01-01

    This study has three parts. The first chapter investigates the construction sectors in the United States and Japan using the analytical framework of interindustry analysis. Six U.S. and five Japanese input-output tables ...

  6. Three papers on input-ouput [sic] energy and environmental accounting

    E-Print Network [OSTI]

    Huang, Sonya (Sonya Y.)

    2013-01-01

    The input-output model, a framework for national accounting and economic modeling, has been popular among regional economists for studying energy and emissions due to its focus on interindustry linkages. In a series of ...

  7. The Supply Chain Management MBA is one of the strategic concentrations at Rutgers Business School. Simply put, Supply Chain Management is how business

    E-Print Network [OSTI]

    School is a driver in reversing this trend by its commitment to excellence and unique strength in world and the Voluntary Interindustry Commerce Solutions (VICS) Association held a joint Logistics Summit on the Rutgers

  8. Insight into methanol synthesis from CO2 hydrogenation on Cu(111): Complex reaction network and the effects of H2O

    SciTech Connect (OSTI)

    Zhao, Yafan; Yang, Yong; Mims, Charles A.; Peden, Charles HF; Li, Jun; Mei, Donghai

    2011-05-31

    Methanol synthesis from CO2 hydrogenation on supported Cu catalysts is of considerable importance in the chemical and energy industries. Although extensive experimental and theoretical efforts have been carried out in the past decades, the most fundamental questions such as the reaction mechanisms and the key reaction intermediates are still in debate. In the present work, a comprehensive reaction network for CO2 hydrogenation to methanol on Cu(111) was studied using periodic density functional theory (DFT) calculations. All of the elementary reaction steps in the reaction network were identified in an unbiased way with the dimer method. Our calculation results show that methanol synthesis from direct hydrogenation of formate on Cu(111) is not feasible due to the high activation barriers for some of the elementary steps. Instead, we find that CO2 hydrogenation to hydrocarboxyl (trans-COOH) is kinetically more favorable than formate in the presence of H2O via a unique proton transfer mechanism. The trans-COOH is then converted into hydroxymethylidyne (COH) via dihydroxycarbene (COHOH) intermediates, followed by three consecutive hydrogenation steps to form hydroxymethylene (HCOH), hydroxymethyl (H2COH), and methanol. This is consistent with recent experimental observations [1], which indicate that direct hydrogenation of formate will not produce methanol under dry hydrogen conditions. Thus, both experiment and computational modeling clearly demonstrate the important role of trace amounts of water in methanol synthesis from CO2 hydrogenation on Cu catalysts. The proposed methanol synthesis route on Cu(111) not only provides new insights into methanol synthesis chemistry, but also demonstrates again that spectroscopically observed surface species are often not critical reaction intermediates but rather spectator species. Pacific Northwest National Laboratory is operated by Battelle for the US Department of Energy.

  9. Atomic Level Green-Kubo Stress Correlation Function for a Model Crystal: An Insight into Molecular Dynamics Results on a Model Liquid

    E-Print Network [OSTI]

    V. A. Levashov

    2014-06-23

    In order to get insight into the connection between the vibrational dynamics and the atomic level Green-Kubo stress correlation function in liquids we consider this connection in a model crystal instead. Of course, vibrational dynamics in liquids and crystals are quite different and it is not expected that the results obtained on a model crystal should be valid for liquids. However, these considerations provide a benchmark to which the results of the previous molecular dynamics simulations can be compared. Thus, assuming that vibrations are plane waves, we derive analytical expressions for the atomic level stress correlation functions in the classical limit and analyze them. These results provide, in particular, a recipe for analysis of the atomic level stress correlation functions in Fourier space and extraction of the wavevector and frequency dependent information. We also evaluate the energies of the atomic level stresses. Obtained energies are significantly smaller than the energies that were obtained in MD simulations of liquids previously. This result suggests that the average energies of the atomic level stresses in liquids and glasses are largely determined by the structural disorder. We discuss this result in the context of equipartition of the atomic level stress energies. Analysis of the previously published data suggests that it is possible to speak about configurational and vibrational contributions to the average energies of the atomic level stresses in a glass state. However, this separation in a liquid state is problematic. We also consider peak broadening in the pair distribution function with increase of distance. We find that peak broadening (by ~40%) occurs due to the transverse vibrational modes, while contribution from the longitudinal modes does not change with distance. Finally, we introduce and consider atomic level transverse current correlation function.

  10. Earth Insights By Phil Rawlings

    E-Print Network [OSTI]

    has jurisdiction. 4. What type of ground heat exchanger is most common on federal facilities ground heat exchanger? The P. E. designation carries no indication of experience with or proficiency/chiller or boiler/cooling tower type mechanical room and heat pump connec tion components and accessories. · Using

  11. Comment > Insight & Opinion The government's

    E-Print Network [OSTI]

    Oxford, University of

    ? Occupying one-sixth of the total land mass of China, Xinjiang possesses some of the nation's largest natural gas and oil reserves, and is strategically situated as a distributor of these resources to energy to ethnic issues, with a reduced role for the Central Politics and Law Commission and its head, Meng Jianzhu

  12. Ecological insights from bacterial networks

    E-Print Network [OSTI]

    Smith, Mark Burnham

    2014-01-01

    Microbes occupy a wide range of important niches ranging from global biogeochemical cycles to metabolism in the human gut. Yet microbes rarely act in isolation. Instead, they thrive in complex communities with myriad ...

  13. Insights & Perspectives Thermogenesis, muscle hyperplasia,

    E-Print Network [OSTI]

    Newman, Stuart A.

    the thoracic portion of the vertebral column at an interface referred to as the ``lumbar'' joint [4]. While of birds, the most species-rich and ecologically diverse of the vertebrate classes, is remarkable

  14. Earth Insights By Phil Rawlings

    E-Print Network [OSTI]

    the majority of the well with standing water. For example, if a well is 500 feet deep and has 450 feet as a water well. However, this technol ogy can only be used in areas where natural conditions fill of standing water, it would be suitable for a standing column well. If it had 100 feet of standing water

  15. Earth Insights By Phil Rawlings

    E-Print Network [OSTI]

    of absorbed energy over an annual cycle. Grid type well field design must consider the effects of system or troubleshooting, send it to Phil Rawlings in care of Geo Outlook, Oklahoma State University, 499 Cordell South and Trainer. Premier Issue Geo Outlook Online #12;

  16. Energy Insight | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:of theClimateElgin,Wind UKEnergiefeld1andTeamWebEnergy

  17. Insight Homes | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsource History View NewGuam:on Openei |sourceAndInformation

  18. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

    SciTech Connect (OSTI)

    Katika, Madhumohan R.; Department of Health Risk Analysis and Toxicology, Maastricht University; Netherlands Toxicogenomics Centre ; Hendriksen, Peter J.M.; Netherlands Toxicogenomics Centre ; Shao, Jia; Department of Health Risk Analysis and Toxicology, Maastricht University; Netherlands Toxicogenomics Centre ; Loveren, Henk van; National Institute for Public Health and the Environment , Bilthoven; Netherlands Toxicogenomics Centre ; Peijnenburg, Ad; Netherlands Toxicogenomics Centre

    2012-10-01

    Deoxynivalenol (DON) or vomitoxin is a commonly encountered type-B trichothecene mycotoxin, produced by Fusarium species predominantly found in cereals and grains. DON is known to exert toxic effects on the gastrointestinal, reproductive and neuroendocrine systems, and particularly on the immune system. Depending on dose and exposure time, it can either stimulate or suppress immune function. The main objective of this study was to obtain a deeper insight into DON-induced effects on lymphoid cells. For this, we exposed the human T-lymphocyte cell line Jurkat and human peripheral blood mononuclear cells (PBMCs) to various concentrations of DON for various times and examined gene expression changes by DNA microarray analysis. Jurkat cells were exposed to 0.25 and 0.5 ?M DON for 3, 6 and 24 h. Biological interpretation of the microarray data indicated that DON affects various processes in these cells: It upregulates genes involved in ribosome structure and function, RNA/protein synthesis and processing, endoplasmic reticulum (ER) stress, calcium-mediated signaling, mitochondrial function, oxidative stress, the NFAT and NF-?B/TNF-? pathways, T cell activation and apoptosis. The effects of DON on the expression of genes involved in ER stress, NFAT activation and apoptosis were confirmed by qRT-PCR. Other biochemical experiments confirmed that DON activates calcium-dependent proteins such as calcineurin and M-calpain that are known to be involved in T cell activation and apoptosis. Induction of T cell activation was also confirmed by demonstrating that DON activates NFATC1 and induces its translocation from the cytoplasm to the nucleus. For the gene expression profiling of PBMCs, cells were exposed to 2 and 4 ?M DON for 6 and 24 h. Comparison of the Jurkat microarray data with those obtained with PBMCs showed that most of the processes affected by DON in the Jurkat cell line were also affected in the PBMCs. -- Highlights: ? The human T cell line Jurkat and human PBMCs were exposed to DON. ? Whole-genome microarray experiments were performed. ? Microarray data indicates that DON affects ribosome and RNA/protein synthesis. ? DON treatment induces ER stress, calcium mediated signaling, NFAT and NF-?B. ? Exposure to DON induces T cell activation, oxidative stress and apoptosis.

  19. Human KZNF Gene Catalog - A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Huntley, S; Baggott, D. M.; Hamilton, A. T.; Tran-Gyamfi, M.; Yang, S.; Kim, J.; Gordon, L.; Branscomb, E.; Stubbs, L.

    Kruppel-type zinc finger (ZNF) motifs are prevalent components of transcription factor proteins in all eukaryotes. KRAB-ZNF proteins, in which a potent repressor domain is attached to a tandem array of DNA-binding zinc-finger motifs, are specific to tetrapod vertebrates and represent the largest class of ZNF proteins in mammals. To define the full repertoire of human KRAB-ZNF proteins, we searched the genome sequence for key motifs and then constructed and manually curated gene models incorporating those sequences. The resulting gene catalog contains 423 KRAB-ZNF protein-coding loci, yielding alternative transcripts that altogether predict at least 742 structurally distinct proteins. Active rounds of segmental duplication, involving single genes or larger regions and including both tandem and distributed duplication events, have driven the expansion of this mammalian gene family. Comparisons between the human genes and ZNF loci mined from the draft mouse, dog, and chimpanzee genomes not only identified 103 KRAB-ZNF genes that are conserved in mammals but also highlighted a substantial level of lineage-specific change; at least 136 KRAB-ZNF coding genes are primate specific, including many recent duplicates. KRAB-ZNF genes are widely expressed and clustered genes are typically not coregulated, indicating that paralogs have evolved to fill roles in many different biological processes. To facilitate further study, we have developed a Web-based public resource with access to gene models, sequences, and other data, including visualization tools to provide genomic context and interaction with other public data sets. [This abstract was copied from: S Huntley, DM Baggott, AT Hamilton, M Tran-Gyamfi, S Yang, J Kim, L Gordon, E Branscomb, and L Stubbs. 2006. A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors, Genome Research 16(5):669 - 677] The website provides the ability to search the online catalog by genomic coordinates, name, locus type, and motifs, to utilize a graphical browser and to download data files.

  20. Structural Insights into the Functional Role of the Hcn Sub-domain of the Receptor-Binding Domain of the Botulinum Neurotoxin Mosaic Serotype C/D

    SciTech Connect (OSTI)

    Zhang, Yanfeng; Gardberg, Anna; Edwards, Tom E.; Sankaran, Banumathi; Robinson, Howard; Varnum, Susan M.; Buchko, Garry W.

    2013-07-01

    Botulinum neurotoxin (BoNT), the causative agent of the deadly neuroparalytic disease botulism, is the most poisonous protein known for humans. Produced by different strains of the anaerobic bacterium Clostridium botulinum, BoNT effects cellular intoxication via a multistep mechanism executed by the three modules of the activated protein. Endocytosis, the first step of cellular intoxication, is triggered by the ~50 kDa, heavy-chain receptor-binding module (HCR) that is specific for a ganglioside and a protein receptor on neuronal cell surfaces. This dual receptor recognition mechanism between BoNT and the host cell’s membrane is well documented and occurs via specific intermolecular interactions with the C-terminal sub-domain, Hcc, of BoNT-HCR. The N-terminal sub-domain of BoNT-HCR, Hcn, comprises ~50% of BoNT-HCR and adopts a B-sheet jelly roll fold. While suspected in assisting cell surface recognition, no unambiguous function for the Hcn sub-domain in BoNT has been indentified. To obtain insights into the potential function of the Hcn sub-domain in BoNT, the first crystal structure of a BoNT with an organic ligand bound to the Hcn sub-domain has been obtained. Here, we describe the crystal structure of BoNT/CD-HCR determined at 1.70 Å resolution with a tetraethylene glycol (PG4) molecule bound in an hydrophobic cleft between B-strands in the B-sheet jelly fold roll of the Hcn sub-domain. The molecule is completely engulfed in the cleft, making numerous hydrophobic (Y932, S959, W966, and D1042) and hydrophilic (S935, W977, L979, N1013, and I1066) contacts with the protein’s side chain and backbone that may mimic in vivo interactions with the phospholipid membranes on neuronal cell surfaces. A sulfate ion was also observed bound to residues T1176, D1177, K1196, and R1243 in the Hcc sub-domain of BoNT/CD-HCR. In the crystal structure of a similar protein, BoNT/D-HCR, a sialic acid

  1. Farm to School Efforts: Innovations and Insights

    E-Print Network [OSTI]

    Galarneau, Tim; Millward, Suzanne; Laird, Megan

    2013-01-01

    taste tests, recycling and composting programs, and trips tothrough recycling and composting programs. 80 Developing ato the fork and through composting and waste diversion, a

  2. INSIGHT INNOVATION IMPACT DESIGN DAY 2015

    E-Print Network [OSTI]

    and Recreation Metro Nashville Public Schools Millennium Space Systems, Inc. NASA Nashville Prosthetics NashvilleStream Energy Systems MAX Mobility Metova Metro Nashville Information Technology Services Metro Nashville Parks Public Library Nissan North America Northrop Grumman Philips Healthcare Quality Manufacturing Systems

  3. The Pion Cloud: Insights into Hadron Structure

    E-Print Network [OSTI]

    A. W. Thomas

    2007-11-14

    Modern nuclear theory presents a fascinating study in contrasting approaches to the structure of hadrons and nuclei. Nowhere is this more apparent than in the treatment of the pion cloud. As this discussion really begins with Yukawa, it is entirely appropriate that this invited lecture at the Yukawa Institute in Kyoto should deal with the issue.

  4. Insights from behavioural economics for ecosystem services

    E-Print Network [OSTI]

    @nationalarchives.gsi.gov.uk. First published in 2013 by Forestry Commission, Silvan House, 231 Corstorphine Road, Edinburgh EH12 7AT Silvan House 231 Corstorphine Road Edinburgh Scotland, EH12 7AT 0131 334 0303 publications of ecological capital. A wide range of impacts on stated preference values are identified in the literature

  5. Insights into Spring 2008 Gasoline Prices

    Reports and Publications (EIA)

    2008-01-01

    Gasoline prices rose rapidly in spring 2007 due a variety of factors, including refinery outages and lower than expected imports. This report explores those factors and looks at the implications for 2008.

  6. Insights into accelerated aging of SSL luminaires

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humiditymore »(RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.« less

  7. Renewable Electricity: Insights for the Coming Decade

    SciTech Connect (OSTI)

    Stark, C.; Pless, J.; Logan, J.; Zhou, E.; Arent, D. J.

    2015-02-01

    A sophisticated set of renewable electricity (RE) generation technologies is now commercially available. Globally, RE captured approximately half of all capacity additions since 2011. The cost of RE is already competitive with fossil fuels in some areas around the world, and prices are anticipated to continue to decline over the next decade. RE options, led by wind and solar, are part of a suite of technologies and business solutions that are transforming electricity sectors around the world. Renewable deployment is expected to continue due to: increasingly competitive economics; favorable environmental characteristics such as low water use, and minimal local air pollution and greenhouse gas (GHG) emissions; complementary risk profiles when paired with natural gas generators; strong support from stakeholders. Despite this positive outlook for renewables, the collapse in global oil prices since mid-2014 and continued growth in natural gas supply in the United States--due to the development of low-cost shale gas--raise questions about the potential impacts of fossil fuel prices on RE. Today, oil plays a very minor role in the electricity sectors of most countries, so direct impacts on RE are likely to be minimal (except where natural gas prices are indexed on oil). Natural gas and RE generating options appear to be more serious competitors than oil and renewables. Low gas prices raise the hurdle for RE to be cost competitive. Additionally, although RE emits far less GHG than natural gas, both natural gas and RE offer the benefits of reducing carbon relative to coal and oil (see Section 4.1 for more detail on the GHG intensity of electricity technologies). However, many investors and decision makers are becoming aware of the complementary benefits of pairing natural gas and renewables to minimize risk of unstable fuel prices and maintain the reliability of electricity to the grid.

  8. The Uncommon Insight of Elinor Ostrom

    E-Print Network [OSTI]

    Bergstrom, Theodore C

    2010-01-01

    along the Silk Road increased their taxes and the amount ofof the Silk Road were controlled by a single empire, and taxthe collection of taxes along the Silk Road, a trading route

  9. INSIGHTS | PERSPECTIVES he aim of nanobiotechnology based

    E-Print Network [OSTI]

    Napp, Nils

    grails of RNA nanotechnology has been to ratio- nally design objects comparable in size and complexity

  10. Applied Solutions Webinar: Insights Into District Energy

    Office of Energy Efficiency and Renewable Energy (EERE)

    Local governments and their communities that inhabit dense locations can take advantage of district heating and/or cooling systems as a way to increase energy efficiency and reliability while...

  11. Footprinting Technique Gives ALS Users New Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    detected," says Ralston. During XFP, the x-rays traveling through a solution generate hydroxyl radicals, which then modify the amino acids in the protein that are solvent...

  12. Building Energy Modeling Insights | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    RSS Welcome to the Building Technologies Office's Building Energy Modeling blog. September 3, 2015 Unmet Hours is a question-and-answer resource for the building energy modeling...

  13. Insights from US ITER: Strategies for Accelerating

    E-Print Network [OSTI]

    Infrastructure Develop materials and systems iteratively #12;5. Organize for success. Avoid creation (new than a program. Mission: ·Rapid materials and fusion systems development, leading-making Design, build and upgrade basic facilities: avoid new facilities and new institutions Plan the teaming

  14. Comprehensible Knowledge Discovery: Gaining Insight from Data

    E-Print Network [OSTI]

    Pazzani, Michael J.

    and provide advice on how to reduce the likelihood of getting a certain disease. Analysis of a political to France, unless France ceased nuclear testing in the South Pacific. France paid a higher price to buy was identified. Most data mining systems cannot be given knowledge of economic and politics and are forced

  15. Insights into accelerated aging of SSL luminaires

    SciTech Connect (OSTI)

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humidity (RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.

  16. New insights on the Dynamic Cellular Metabolism

    E-Print Network [OSTI]

    Ildefonso M. De la Fuente

    2015-01-09

    A large number of studies have shown the existence of metabolic covalent modifications in different molecular structures, able to store biochemical information that is not encoded by the DNA. Some of these covalent mark patterns can be transmitted across generations (epigenetic changes). Recently, the emergence of Hopfield-like attractor dynamics has been observed in the self-organized enzymatic networks, which have the capacity to store functional catalytic patterns that can be correctly recovered by the specific input stimuli. The Hopfield-like metabolic dynamics are stable and can be maintained as a long-term biochemical memory. In addition, specific molecular information can be transferred from the functional dynamics of the metabolic networks to the enzymatic activity involved in the covalent post-translational modulation so that determined functional memory can be embedded in multiple stable molecular marks. Both the metabolic dynamics governed by Hopfield-type attractors (functional processes) and the enzymatic covalent modifications of determined molecules (structural dynamic processes) seem to represent the two stages of the dynamical memory of cellular metabolism (metabolic memory). Epigenetic processes appear to be the structural manifestation of this cellular metabolic memory. Here, a new framework for molecular information storage in the cell is presented, which is characterized by two functionally and molecularly interrelated systems: a dynamic, flexible and adaptive system (metabolic memory) and an essentially conservative system (genetic memory). The molecular information of both systems seems to coordinate the physiological development of the whole cell.

  17. Academy Insights Vol. 4, No. 10

    E-Print Network [OSTI]

    Blackwell, Keith

    of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine Morgan-Zinsser Fellow

  18. Lipidomics: New Insight Into Kidney Disease

    E-Print Network [OSTI]

    Zhao, Y-Y; Vaziri, ND; Lin, R-C

    2015-01-01

    bilayer structure, energy storage, signal ARTICLE IN PRESSserve as cellular energy storage and play an important role

  19. Insights Gained from Testing Alternate Cell Designs

    SciTech Connect (OSTI)

    J. E. O'Brien; C. M. Stoots; J. S. Herring; G. K. Housley; M. S. Sohal; D. G. Milobar; Thomas Cable

    2009-09-01

    The Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cell for large-scale hydrogen production from steam over a temperature range of 800 to 900ºC. The INL has been testing various solid oxide cell designs to characterize their electrolytic performance operating in the electrolysis mode for hydrogen production. Some results presented in this report were obtained from cells, initially developed by the Forschungszentrum Jülich and now manufactured by the French ceramics firm St. Gobain. These cells have an active area of 16 cm2 per cell. They were initially developed as fuel cells, but are being tested as electrolytic cells in the INL test stands. The electrolysis cells are electrode-supported, with ~10 µm thick yttria-stabilized zirconia (YSZ) electrolytes, ~1400 µm thick nickel-YSZ steam-hydrogen electrodes, and manganite (LSM) air-oxygen electrodes. The experiments were performed over a range of steam inlet mole fractions (0.1 to 0.6), gas flow rates, and current densities (0 to 0.6 A/cm2). Steam consumption rates associated with electrolysis were measured directly using inlet and outlet dewpoint instrumentation. On a molar basis, the steam consumption rate is equal to the hydrogen production rate. Cell performance was evaluated by performing DC potential sweeps at 800, 850, and 900°C. The voltage-current characteristics are presented, along with values of area-specific resistance as a function of current density. Long-term cell performance is also assessed to evaluate cell degradation. Details of the custom single-cell test apparatus developed for these experiments are also presented. NASA, in conjunction with the University of Toledo, has developed another fuel cell concept with the goals of reduced weight and high power density. The NASA cell is structurally symmetrical, with both electrodes supporting the thin electrolyte and containing micro-channels for gas diffusion. This configuration is called a bi-electrode supported cell or BSC. The electrodes are made by freeze-casting, a modified tape casting technique which creates the many micro-channels in the YSZ electrode green tape. This report presents results of the INL’s testing of this new solid oxide cell design as an electrolyzer. Gas composition, operating voltage, and other parameters were varied during testing. Results to date show the NASA cell to be a promising design for both high power-to-weight fuel cell and electrolyzer applications.

  20. Farm to School Efforts: Innovations and Insights

    E-Print Network [OSTI]

    Galarneau, Tim; Millward, Suzanne; Laird, Megan

    2013-01-01

    unified school district food waste diversion project finalControl Agency found that food waste accounted for 23.8% ofprogram that composted food waste from three elementary

  1. Network-based Analysis and Insights | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shinesSolar Photovoltaic(MillionNature and Origin What

  2. Space-Time Insight | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop Inc JumpHeter BatterySolarfin JumpOpenColorado) JumpSoyminas Biodiesel

  3. DOE Research and Development Accomplishments Interesting Insights

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministration Medal01Technical Information--ScientificDatabase Help The DOE DNA

  4. IDC Energy Insights | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsource History View NewGuam:on Openei | Open Energy2010) | OpenHywindIBEW LocalIDC Energy

  5. Analyzing ocean mixing reveals insight on climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory of raregovAboutRecovery ActTools to someone by E-mailatAnalysisJune »

  6. Footprinting Technique Gives ALS Users New Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journal Article) |FinalIndustrialFollowing the Technical

  7. Footprinting Technique Gives ALS Users New Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journal Article) |FinalIndustrialFollowing the TechnicalFootprinting

  8. Footprinting Technique Gives ALS Users New Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journal Article) |FinalIndustrialFollowing the

  9. The continuance of a rise in prices in a Western economy well after a downturn in final demands, termed "Stagflation," has been a puzzle

    E-Print Network [OSTI]

    Wickerhauser, M. Victor

    Abstract The continuance of a rise in prices in a Western economy well after a downturn in final include the use of input-output (or interindustry) tables. In conclusion, at the end of this paper, attention is drawn to the computability of projections of industrial price-levels and rates of return

  10. Evolutionary insights into scleractinian corals using comparative genomic hybridizations

    E-Print Network [OSTI]

    Aranda, Manuel; DeSalvo, Michael K; Bayer, Till; Medina, Monica; Voolstra, Christian R

    2012-01-01

    AR, Mishmar D: Mitochondrial bioenergetics as a major motiveinstance, mitochondrial bioenergetics has been dis- cussedtion of mitochondrial bioenergetics and thus a phase of

  11. Exhumation Of The Peruvian Andes; Insights From Mineral Chronometers

    E-Print Network [OSTI]

    Michalak, Melanie

    2013-01-01

    characterization and zircon U-Pb geochronologic constraints from the Peruvian Eastern Cordilleran granitoids. Geological

  12. Exhumation Of The Peruvian Andes; Insights From Mineral Chronometers

    E-Print Network [OSTI]

    Michalak, Melanie

    2013-01-01

    1989, Cretaceous sequence stratigraphy of Peru and Bolivia:sequences of the West Peruvian Trough The Cretaceous stratigraphy

  13. Descended from Darwin Insights into the History of

    E-Print Network [OSTI]

    -1-60618-991-7 US ISSN: 0065-9746 Library of Congress Cataloging-in-Publication Data is available from the Library, impresses by its thoroughness and sophisticated understanding of religious and other trends in the mid edition of the Origin, the beginning of a trend that sees the early Origin as being in many respects

  14. Observational Insights into Aerosol Formation from Isoprene David R. Worton,*,,

    E-Print Network [OSTI]

    Goldstein, Allen

    , Ronald C. Cohen, John H. Seinfeld, and Allen H. Goldstein,$ Department of Environmental Science, Policy and Management, Department of Chemistry, University of California, Berkeley, California 94720, United States Aerosol Dynamics Inc., Berkeley, California 94710, United States § Department of Environmental Sciences

  15. Malaria and global change: Insights, uncertainties and possible surprises

    SciTech Connect (OSTI)

    Martin, P.H.; Steel, A.

    1996-12-31

    Malaria may change with global change. Indeed, global change may affect malaria risk and malaria epidemiology. Malaria risk may change in response to a greenhouse warming; malaria epidemiology, in response to the social, economic, and political developments which a greenhouse warming may trigger. To date, malaria receptivity and epidemiology futures have been explored within the context of equilibrium studies. Equilibrium studies of climate change postulate an equilibrium present climate (the starting point) and a doubled-carbon dioxide climate (the end point), simulate conditions in both instances, and compare the two. What happens while climate changes, i.e., between the starting point and the end point, is ignored. The present paper focuses on malaria receptivity and addresses what equilibrium studies miss, namely transient malaria dynamics.

  16. New insights into small-scale vertical distributions of phytoplankton

    E-Print Network [OSTI]

    Prairie, Jennifer Chan

    2011-01-01

    evaluation of backscatter and forward- scatter fiber-optic sensors.evaluation of backscatter and forward- scatter fiber-optic sensors.evaluation of backscatter and forward- scatter fiber-optic sensors.

  17. Capping protein: new insights into mechanism and regulation

    E-Print Network [OSTI]

    Cooper, John

    -helical polymers of globular subunits (Figure 1) that are arranged head to tail (Figure 2) [10]. The filaments have and the dissociation of subunits from the pointed ends [17]. Actin subunit flux and recycling are facilitated by actin

  18. Insights into assembly of the macromolecular inflammasome complex

    E-Print Network [OSTI]

    Monie, Tom P.; Boyle, Joseph P.

    2014-12-23

    underpinning the different appearances of the inflammasome specks visualised to date. This may well require application of various technologies to multiple systems to look for consistency. Certainly applying the high- resolution techniques used to visualise... inflammasome NLRP3 inflammasome AIM2 inflammasome NLRC4 inflammasome Figure 1: General architecture and organisation of the inflammasome. (A) Domain architecture of the major inflammasome forming pattern recognition receptors and apoptosome forming proteins...

  19. Insights into Particle Cycling from Thorium and Particle Data

    E-Print Network [OSTI]

    Lam, Phoebe J; Marchal, Olivier

    2015-01-01

    J. Mar. Res. 58:675–707 Bacon MP, Anderson RF. 1982.Geophys. Res. 87:2045–56 Bacon MP, Huh C-A, Fleer AP, DeuserEdmond JM, Ketten DR, Bacon MP, Silker WB. 1977. Chemistry,

  20. New imaging technique provides improved insight into controlling...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superhot, charged plasma gas that fuels fusion reactions in magnetic devices called tokamaks. This gas is subject to instabilities that cause it to leak from the magnetic fields...

  1. Noble gases on metal surfaces: Insights on adsorption site preference

    SciTech Connect (OSTI)

    Chen, De-Li; Al-Saidi, W. A.; Johnson, J. Karl

    2011-12-19

    We use a nonlocal van der Waals density functional (vdW-DF) approach to reexamine the problem of why noble gases are experimentally observed to adsorb on low-coordination atop sites rather than on high-coordination hollow sites for several different metal surfaces. Previous calculations using density functional theory (DFT) within the local density approximation (LDA) ascribed the site preference to reduced Pauli repulsion at atop sites, largely due to reduced exchange repulsion within LDA-DFT. In contrast, our vdW-DF calculations show that site preference is not due to differences in the exchange repulsion at all, but rather the result of a delicate balance between the electrostatic and kinetic energies; surprisingly, exchange-correlation energies play a negligible role in determining site preference. In contrast to previous calculations, we find that experimental results cannot be explained in terms of binding energy differences between atop and hollow sites. Instead, we show that the hollow sites are transition states rather than minima on the two-dimensional potential energy surface, and therefore not likely to be observed in experiments. This phenomenon is quite general, holding for close-packed and non-close-packed metal surfaces. We show that inclusion of nonlocal vdW interactions is crucial for obtaining results in quantitative agreement with experiments for adsorption energies, equilibrium distances, and vibrational energies.

  2. Innovation pathways in technology intensive government organizations : insights from NASA

    E-Print Network [OSTI]

    Szajnfarber, Zoe

    2011-01-01

    Despite a rich legacy of impressive technological accomplishments (e.g., project Apollo, the Hubble Space Telescope) in recent years, the ability of government space agencies to deliver on their promises has increasingly ...

  3. Descended from Darwin Insights into the History of

    E-Print Network [OSTI]

    -1-60618-991-7 US ISSN: 0065-9746 Library of Congress Cataloging-in-Publication Data is available from the Library at a conference on human evolu- tion and classification sponsored by the Wenner-Gren Foundation at Burg classification, which he characterized as "radical."5 He strongly reaffirmed his long-held position placing apes

  4. Insights from Hydrogen Refueling Station Manufacturing Competitiveness Analysis

    SciTech Connect (OSTI)

    Mayyas, Ahmad

    2015-12-18

    In work for the Clean Energy Manufacturing Analysis Center (CEMAC), NREL is currently collaborating with Great Lakes Wind Network in conducting a comprehensive hydrogen refueling stations manufacturing competitiveness and supply chain analyses. In this project, CEMAC will be looking at several metrics that will facilitate understanding of the interactions between and within the HRS supply chain, such metrics include innovation potential, intellectual properties, learning curves, related industries and clustering, existing supply chains, ease of doing business, and regulations and safety. This presentation to Fuel Cell Seminar and Energy Exposition 2015 highlights initial findings from CEMAC's analysis.

  5. Descended from Darwin Insights into the History of

    E-Print Network [OSTI]

    in 1953 to a Harvard professorship. It was no acci- dent he wrote little by way of personal autobiography

  6. Molecular? recognition? from? atomic ?interactions:?? insights ?into ?drug ?discovery?

    E-Print Network [OSTI]

    Higueruelo, Alicia Perez

    2012-05-08

    to be part of that team. I thank UCB for sponsoring this project when I was an UCB employee and for its continuous commitment after the closure of the site. I thank the BBSRC for funding the CASE studentship. I thank my past and present colleagues... -protein complexes with known inhibitors 3D Three Dimensional AASA Apolar Solvent Accessible Surface Area ACD-SC Available Chemical Directory for Screening Compounds ADMET Absorption Distribution Metabolism Excretion and Toxicity ADP Adenosine Diphosphate AMP...

  7. Mechanistic Insights into the Diverged Enzymes of the Amidohydrolase Superfamily 

    E-Print Network [OSTI]

    Nguyen, Tinh T.

    2011-02-22

    The amidohydrolase superfamily is a functionally diverse set of enzymes that catalyzes predominantly hydrolysis reactions involving sugars, nucleic acids, amino acids, and organophosphate esters. A more divergent member ...

  8. Constraints and selection: insights from microsporogenesis in Asparagales

    E-Print Network [OSTI]

    adaptations. Whereas this concept has long been debated on theoretical grounds, it has been investigated (1979) triggered a renewed interest in evolu- tionary explanations of organismal features that may 1999). On the other hand, some studies investigating this question favored adaptive explanations over

  9. PRIMARY RESEARCH PAPER Stranding events provide indirect insights into the

    E-Print Network [OSTI]

    Hays, Graeme

    and persistence of jellyfish medusae (Cnidaria: Scyphozoa) Jonathan David Roy Houghton Æ Thomas K. Doyle Æ John Davenport Æ Martin K. S. Lilley Æ Rory P. Wilson Æ Graeme C. Hays Received: 8 December 2006 / Revised: 10 Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland T. K. Doyle Á J. Davenport

  10. KAMPALA'S PLAUSIBLE URBAN FLOODING FUTURES: BUILDING INSIGHTS THROUGH

    E-Print Network [OSTI]

    for intervention can be modelled and evaluated. · Already improved solid waste management has been taken up and built environments) (Spatial) data issues: Spatial-temporal coverage Completeness Accuracy Gaps

  11. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    This information will lead to a variety of beneficial applications including pressure switches, smart body armor, pressure sensors, or shock absorbing materials. A recent review...

  12. Voices of Experience: New Guide Offers Utilities' Insights on...

    Office of Environmental Management (EM)

    the Power Over Energy campaign to empower consumers to make smart decisions about their electricity consumption. For additional information about national efforts to modernize...

  13. 'Insights of the Decade' Enabled by NERSC - NERSC Center News...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sky. Planck is observing the sky at nine wavelengths of light, ranging from infrared to radio waves. The result is a windfall of data on known and never-before-seen cosmic...

  14. A Minnesota Blizzard Provides Insight into Utility-Scale Wind...

    Office of Environmental Management (EM)

    the researchers were ready. They had positioned a large searchlight with reflecting optics designed to create a light sheet reflecting off snow particles in an area that was 36...

  15. Metagenomic Insights into Evolution of a Heavy Metal-Contaminated...

    Office of Scientific and Technical Information (OSTI)

    could be a key mechanism in rapidly responding and adapting to environmental contamination. The results presented in this study have important implications in understanding,...

  16. Coronary Artery Disease Progression: Insights from Cardiac CT

    E-Print Network [OSTI]

    Yeh, V; Nakanishi, R; Budoff, MJ

    2015-01-01

    with type 2 diabetes: the PERISCOPE randomized controlled20], ILLUSTRATE [21], PERISCOPE [22], and STRADIVARIUS [23].

  17. Voices of Experience: New Guide Offers Utilities' Insights on...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for consumers to better manage their electricity use, save money, and reduce their carbon footprint. To take advantage of these new choices, consumers need to understand the...

  18. Review: Sonoran Desert Life: Understanding, Insight and Enjoyment

    E-Print Network [OSTI]

    Javed, Muhammad Tayyeb

    2010-01-01

    and Materials Engineering, Pakistan Institute of EngineeringP.O. Nilore, Islamabad, Pakistan. TEL: 92-51-2207381-3 xby Muhammed Tayyeb Javed Pakistan Institute of Engineering

  19. Evolutionary insights into scleractinian corals using comparative genomic hybridizations

    E-Print Network [OSTI]

    Aranda, Manuel; DeSalvo, Michael K; Bayer, Till; Medina, Monica; Voolstra, Christian R

    2012-01-01

    Transcriptomic responses to heat stress and bleaching in theof the response to heat stress in hepatopancreas tissue ofearly gene response to heat stress in a coral reef fish. Mol

  20. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  1. Insights into Particle Cycling from Thorium and Particle Data

    E-Print Network [OSTI]

    Lam, Phoebe J; Marchal, Olivier

    2015-01-01

    RF. 1982. Distribution of thorium isotopes between dissolvedcolumn distributions of thorium isotopes in the westernM. 1987. Scavenging of thorium in the ocean. J. Geophys.

  2. Human mouth microbes provide insight into health, disease | ornl...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SR1 and other bacteria because they use a different genetic alphabet. "In the big pool of bacteria, genes can be exchanged between species and can contribute to increased...

  3. Insights into Corporate Energy Management Trends - Focus on Texas 

    E-Print Network [OSTI]

    Fyock, C.

    2012-01-01

    Generation Have plans for future on-site cogeneration or renewable energy installation but don?t have today Yes Plan to Yes Plan to Texas HQ Total ? Less prevalent among Texas based companies (also less often cited as a goal) Copyright ? 2010... Deloitte Development LLC and Harrison Group. All rights reserved. 4 Business Highlights (continued) 3. Renewables and Self-Generation? Over one-third of companies have some form of self-generation and another 17% have plans. Green energy participation...

  4. New Insights into Fish Ecology via Nuclear Microscopy of Otoliths

    E-Print Network [OSTI]

    Limburg, Karin E.

    ,4]. Otolith elemental and stable isotopic composition yields information about the habitat, thermal regimes in otoliths, many of them at trace levels [4]. Whereas bulk analysis with methods such as ICP mass at Lund University [10]. PIXE, an accelerator-based technique, combines the analytical breadth of energy

  5. Insights from Agricultural GHG Offset studies that might

    E-Print Network [OSTI]

    McCarl, Bruce A.

    (agriculture only) Pacific Northwest - West Side Pacific Northwest - East Side South Central Southern Plains Livestock Herd Size Emission X X Livestock System Change Emission X X Manure Management Emission X X Rice supply and demand Regression ­ Pesticide usage, Non Ag water use Extreme event effects Adaptation obs

  6. Ab Initio Insights on the Shapes of Platinum Nanocatalysts

    E-Print Network [OSTI]

    Curtarolo, Stefano

    © 2011 American Chemical Society ABSTRACT Catalytic, chemical, optical, and electronic properties Carolina 27708, United States C atalysis plays a fundamental role in many fields of chemical and en- ergy of chemical reactions (i.e., to increase and re- duce the amounts of desirable and undesir- able products

  7. Insight from Fukushima Daiichi Unit 3 Investigations using MELCOR

    SciTech Connect (OSTI)

    Robb, Kevin R.; Francis, Matthew W.; Ott, Larry J.

    2014-01-01

    During the emergency response period of the accidents that took place at Fukushima Daiichi in March of 2011, researchers at Oak Ridge National Laboratory (ORNL) conducted a number of studies using the MELCOR code to help understand what was occurring and what had occurred. During the post-accident period, the Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC) jointly sponsored a study of the Fukushima Daiichi accident with collaboration among Oak Ridge, Sandia, and Idaho national laboratories. The purpose of the study was to compile relevant data, reconstruct the accident progression using computer codes, assess the codes predictive capabilities, and identify future data needs. The current paper summarizes some of the early MELCOR simulations and analyses conducted at ORNL of the Fukushima Daiichi Unit 3 accident. Extended analysis and discussion of the Unit 3 accident is also presented taking into account new knowledge and modeling refinements made since the joint DOE/NRC study.

  8. New Insights on Jupiter's Deep Water Abundance from Disequilibrium Species

    E-Print Network [OSTI]

    Wang, Dong; Lunine, Jonathan; Mousis, Olivier

    2014-01-01

    The bulk water abundance on Jupiter potentially constrains the planet's formation conditions. We improve the chemical constraints on Jupiter's deep water abundance in this paper. The eddy diffusion coefficient is used to model vertical mixing in planetary atmosphere, and based on laboratory studies dedicated to turbulent rotating convection, we propose a new formulation of the eddy diffusion coefficient for the troposphere of giant planets. The new formulation predicts a smooth transition from the slow rotation regime (near the equator) to the rapid rotation regime (near the pole). We estimate an uncertainty for the newly derived coefficient of less than 25$\\%$, which is much better than the one order of magnitude uncertainty used in the literature. We then reevaluate the water constraint provided by CO, using the newer eddy diffusion coefficient. We considered two updated CO kinetic models, one model constrains the water enrichment (relative to solar) between 0.1 and 0.75, while the other constrains the wate...

  9. Physics of Reliability: Evaluating Design Insights for Component...

    Broader source: Energy.gov (indexed) [DOE]

    that will ultimately lead to reduced risk (both perceived and actual) in long-term PV performance. This will lower the cost of solar energy by improving power outputs over...

  10. Population genetic and phylogeographic insights into the phyllosomal odyssey

    E-Print Network [OSTI]

    Iacchei, Matthew

    2014-01-01

    19. Johnson, M.W. (1960) The offshore drift of larvae of thethat the larvae found far offshore, past local entrain- mentthe lar- vae found far offshore would be temporarily re-

  11. Voices of Experience | Insights into Advanced Distribution Management...

    Office of Environmental Management (EM)

    Act (ARRA) of 2009 spurred investments in smart grid technology and programs at utilities across the country. The Smart Grid Investment Grant program and Smart Grid...

  12. Sodium channel activation mechanisms. Insights from deuterium oxide substitution

    SciTech Connect (OSTI)

    Alicata, D.A.; Rayner, M.D.; Starkus, J.G. )

    1990-04-01

    Schauf and Bullock, using Myxicola giant axons, demonstrated that solvent substitution with deuterium oxide (D2O) significantly affects both sodium channel activation and inactivation kinetics without corresponding changes in gating current or tail current rates. They concluded that (a) no significant component of gating current derives from the final channel opening step, and (b) channels must deactivate (during tail currents) by a different pathway from that used in channel opening. By contrast, Oxford found in squid axons that when a depolarizing pulse is interrupted by a brief (approximately 100 microseconds) return to holding potential, subsequent reactivation (secondary activation) is very rapid and shows almost monoexponential kinetics. Increasing the interpulse interval resulted in secondary activation rate returning towards control, sigmoid (primary activation) kinetics. He concluded that channels open and close (deactivate) via the same pathway. We have repeated both sets of observations in crayfish axons, confirming the results obtained in both previous studies, despite the apparently contradictory conclusions reached by these authors. On the other hand, we find that secondary activation after a brief interpulse interval (50 microseconds) is insensitive to D2O, although reactivation after longer interpulse intervals (approximately 400 microseconds) returns towards a D2O sensitivity similar to that of primary activation. We conclude that D2O-sensitive primary activation and D2O-insensitive tail current deactivation involve separate pathways. However, D2O-insensitive secondary activation involves reversal of the D2O-insensitive deactivation step. These conclusions are consistent with parallel gate models, provided that one gating particle has a substantially reduced effective valence.

  13. Strategies for aluminum recycling : insights from material system optimization

    E-Print Network [OSTI]

    Li, Preston Pui-Chuen

    2005-01-01

    The dramatic increase in aluminum consumption over the past decades necessitates a societal effort to recycle and reuse these materials to promote true sustainability and energy savings in aluminum production. However, the ...

  14. United Press International News. Analysis. Insight.TM

    E-Print Network [OSTI]

    Rogers, John A.

    Zogby/UPI Polls Religi advertisement advertisement Scientists create flexible electronics ARGONNE, Ill., April 3 (UPI) -- U.S. scientists are developing flexible electronic structures with the potential. In addition to a biomedical impact, flexible electronics are important for energy technology as flexible

  15. Throughput to Insight… and Tackling the Messy Bits Between

    SciTech Connect (OSTI)

    Glasscock, Jarret [Cofactor Genomics

    2009-05-28

    Jarret Glasscock of Cofactor Genomics talks about short-read platforms at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  16. Insight into obscure transition uncovered by X-rays | Argonne...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of X-ray techniques. This transition has ramifications for material design for electronics and sensors. The transition between being electrically conductive (metallic) at...

  17. Buckling of microtubules: An insight by molecular and continuum mechanics

    SciTech Connect (OSTI)

    Zhang, Jin; Meguid, S. A.

    2014-10-27

    The molecular structural mechanics method has been extended to investigate the buckling of microtubules (MTs) with various configurations. The results indicate that for relative short MTs the shear deformation effect, rather than the nonlocal effect, is mainly responsible for the limitation of their widely used Euler beam description and the observed length-dependence of their bending stiffness. In addition, the configuration effect of MTs is also studied and considered as an explanation for the large scattering of the critical buckling force and bending stiffness observed in existing experiments. This configuration effect is also found to mainly originate from the geometry of the MTs and is mainly determined by the protofilament number.

  18. Physics of Reliability: Evaluating Design Insights for Component...

    Broader source: Energy.gov (indexed) [DOE]

    a tool to study the fundamentals behind performance and metastabilities of CdTe thin-film photovoltaics (PV). The core of the solution will be a multi-level solver that combines...

  19. Structural Insights into Ca2 -dependent Regulation of

    E-Print Network [OSTI]

    Ikura, Mitsuhiko

    , 351-0198 Saitama, Japan, and the **Department of Pharmacology, School of Medicine, Case Western and negatively regulated by cytosolic Ca2 (3­6), important for the generation of repetitive Ca2 transients known as Ca2 spikes and waves (1). Ca2 -depend- ent activation of InsP3R1 contributes to the fast rising phase

  20. An insights report by the Energy Technologies Institute

    E-Print Network [OSTI]

    García Pérez Gamarra, Javier

    -hydrogen and bio-electricity are produced in preference to biofuels and bio-methane » Bio-heat is deployed across

  1. Molecular insights into the niche of harmful brown tides

    E-Print Network [OSTI]

    Wurch, Louie L. (Louie Lorne)

    2011-01-01

    Recurrent brown tide blooms caused by the harmful alga Alureococcus anophagefferens have decimated coastal ecosystems and shellfisheries along the Eastern U.S and South Africa. The exact mechanisms controlling bloom ...

  2. Specific Cation Effects in Biological Systems: Thermodynamic and Spectroscopic Insights 

    E-Print Network [OSTI]

    Kherb, Jaibir

    2012-02-14

    as these polypeptides can be easily genetically engineered to observe the effect of specific amino acid residues and peptide chain length on these salt interactions. Both of these biopolymers are also highly thermoresponsive as their aqueous solutions undergo a...

  3. Public Interest Litigation: Insights from Theory and Practice

    E-Print Network [OSTI]

    Cummings, Scott L; Rhode, Deborah L.

    2009-01-01

    For those seeking social impact through law, the challengeways that maximize social impact. 187. See generally Robertand their likely social impact. A deeper under- standing of

  4. Insight into hydrogenation of graphene: Effect of hydrogen plasma chemistry

    SciTech Connect (OSTI)

    Felten, A.; Nittler, L.; Pireaux, J.-J.; McManus, D.; Rice, C.; Casiraghi, C.

    2014-11-03

    Plasma hydrogenation of graphene has been proposed as a tool to modify the properties of graphene. However, hydrogen plasma is a complex system and controlled hydrogenation of graphene suffers from a lack of understanding of the plasma chemistry. Here, we correlate the modifications induced on monolayer graphene studied by Raman spectroscopy with the hydrogen ions energy distributions obtained by mass spectrometry. We measure the energy distribution of H{sup +}, H{sub 2}{sup +}, and H{sub 3}{sup +} ions for different plasma conditions showing that their energy strongly depends on the sample position, pressure, and plasma power and can reach values as high as 45?eV. Based on these measurements, we speculate that under specific plasma parameters, protons should possess enough energy to penetrate the graphene sheet. Therefore, a graphene membrane could become, under certain conditions, transparent to both protons and electrons.

  5. The Big Data Newsvendor: Practical Insights from Machine Learning Analysis

    E-Print Network [OSTI]

    Rudin, Cynthia

    2013-10-16

    We present a version of the newsvendor problem where one has n observations of p features as well as past demand. We consider both \\big data" (p=n = O(1)) as well as small data (p=n = o(1)). For small data, we provide a ...

  6. The Big Data Newsvendor: Practical Insights from Machine Learning

    E-Print Network [OSTI]

    Rudin, Cynthia

    2014-02-06

    We investigate the newsvendor problem when one has n observations of p features related to the demand as well as past demands. Both small data (p=n = o(1)) and big data (p=n = O(1)) are considered. For both cases, we propose ...

  7. New insights into treating Parkinson's from yeast, stem cell experiments

    E-Print Network [OSTI]

    Lindquist, Susan

    cells created from Parkinson's disease patients' stem cells. The work, described in a pair of studies problems of Parkinson's disease may seem tenuous at best, the researchers engineered the yeast and a scientist in the Lindquist laboratory, recruited patients with an aggressive genetic form of Parkinson

  8. Exhumation Of The Peruvian Andes; Insights From Mineral Chronometers

    E-Print Network [OSTI]

    Michalak, Melanie

    2013-01-01

    adjustment of the geothermal gradient due to post-intrusiveenough that the geothermal gradient is the same everywhere,assigning a 25°C/km geothermal gradient and 180°C closure

  9. Insights into the homeostatic regulation of I kappa B alpha

    E-Print Network [OSTI]

    Lisabeth, Erika Mathes

    2009-01-01

    instance, the protein NAD(P)H quinine oxidase (NQO1) is aNAD(P)H to reduce various quinines. NQO1 has been found to

  10. Insights into bilaterian evolution from three spiralian genomes

    SciTech Connect (OSTI)

    Simakov, Oleg; Marletaz, Ferdinand; Cho, Sung-Jin; Edsinger-Gonzales, Eric; Havlak, Paul; Hellsten, Uffe; Kuo, Dian-Han; Larsson, Tomas; Lv, Jie; Arendt, Detlev; Savage, Robert; Osoegawa, Kazutoyo; de Jong, Pieter; Grimwood, Jane; Chapman, Jarrod A.; Shapiro, Harris; Otillar, Robert P.; Terry, Astrid Y.; Boore, Jeffrey L.; Grigoriev, Igor V.; Lindberg, David R.; Seaver, Elaine C.; Weisblat, David A.; Putnam, Nicholas H.; Rokhsar, Daniel S.; Aerts, Andrea

    2012-01-07

    Current genomic perspectives on animal diversity neglect two prominent phyla, the molluscs and annelids, that together account for nearly one-third of known marine species and are important both ecologically and as experimental systems in classical embryology1, 2, 3. Here we describe the draft genomes of the owl limpet (Lottia gigantea), a marine polychaete (Capitella teleta) and a freshwater leech (Helobdella robusta), and compare them with other animal genomes to investigate the origin and diversification of bilaterians from a genomic perspective. We find that the genome organization, gene structure and functional content of these species are more similar to those of some invertebrate deuterostome genomes (for example, amphioxus and sea urchin) than those of other protostomes that have been sequenced to date (flies, nematodes and flatworms). The conservation of these genomic features enables us to expand the inventory of genes present in the last common bilaterian ancestor, establish the tripartite diversification of bilaterians using multiple genomic characteristics and identify ancient conserved long- and short-range genetic linkages across metazoans. Superimposed on this broadly conserved pan-bilaterian background we find examples of lineage-specific genome evolution, including varying rates of rearrangement, intron gain and loss, expansions and contractions of gene families, and the evolution of clade-specific genes that produce the unique content of each genome.

  11. Insights on Why Companies Pay Attention to Energy Management 

    E-Print Network [OSTI]

    Norland, D.

    2001-01-01

    National data show that improvement in industrial energy efficiency has stagnated for a decade and a half. Most corporations pay scant attention to energy use. Yet some companies exhibit outstanding performance in lowering their energy use per unit...

  12. United Press International News. Analysis. Insight.TM

    E-Print Network [OSTI]

    Rogers, John A.

    and linear nanotubes as thin-film semiconductor material. Despite the attractive electrical properties Zogby/UPI Polls Religi advertisement advertisement Nanotubes used as semiconductor material CHAMPAIGNTrack - Nanotubes used as semiconductor material 3/28/2007http://www.upi.com/NewsTrack/Science/Nanotubes_used_as_semiconductor_material

  13. New Insights into the Mechanism of Bacterial Metal Respiration

    SciTech Connect (OSTI)

    DiChristina, Thomas J.

    2004-04-17

    This project goal is to identify genes and gene products required for microbial metal reduction: reductive dissolution of iron; reductive dissolution of manganese; reductive precipitation of selenium; reductive precipitation of uranium; and reductive precipitation of technetium.

  14. INSIGHTS INTO FILAMENT ERUPTION ONSET FROM SOLAR DYNAMICS OBSERVATORY OBSERVATIONS

    SciTech Connect (OSTI)

    Sterling, Alphonse C.; Moore, Ronald L.; Freeland, Samuel L. E-mail: ron.moore@nasa.gov

    2011-04-10

    We examine the buildup to and onset of an active region filament confined eruption of 2010 May 12, using EUV imaging data from the Solar Dynamics Observatory (SDO) Atmospheric Imaging Array and line-of-sight magnetic data from the SDO Helioseismic and Magnetic Imager. Over the hour preceding eruption the filament undergoes a slow rise averaging {approx}3 km s{sup -1}, with a step-like trajectory. Accompanying a final rise step {approx}20 minutes prior to eruption is a transient preflare brightening, occurring on loops rooted near the site where magnetic field had canceled over the previous 20 hr. Flow-type motions of the filament are relatively smooth with speeds {approx}50 km s{sup -1} prior to the preflare brightening and appear more helical, with speeds {approx}50-100 km s{sup -1}, after that brightening. After a final plateau in the filament's rise, its rapid eruption begins, and concurrently an outer shell 'cocoon' of the filament material increases in emission in hot EUV lines, consistent with heating in a newly formed magnetic flux rope. The main flare brightenings start {approx}5 minutes after eruption onset. The main flare arcade begins between the legs of an envelope-arcade loop that is nearly orthogonal to the filament, suggesting that the flare results from reconnection among the legs of that loop. This progress of events is broadly consistent with flux cancellation leading to formation of a helical flux rope that subsequently erupts due to onset of a magnetic instability and/or runaway tether cutting.

  15. Course Title: Unconscious Bias: Insights For Inclusive Management...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    301-928-5103 Skip Pettit Program InstructorsFacilitators Dr. Lester Hoffman, MA, PhD With a PhD from Harvard University, Dr. Hoffman keynotes and facilitates workshops on...

  16. Descended from Darwin Insights into the History of

    E-Print Network [OSTI]

    's a revolution going on in ecology and biogeography. . . . The next great innovator in paleoecology

  17. Crustal structure of central Lake Baikal: Insights into intracontinental rifting

    E-Print Network [OSTI]

    ten Brink, Uri S.; Taylor, Michael Halford

    2002-07-16

    [Mats, 1993]. Where exposed or drilled, the Oligocene to Pliocene sediments often comprise alternating beds of clay, siltstones, and sand deposited in a lacustrine environment [Mats, 1993]. Rifting is generally considered to have intensified since... rift system along the Atlantic coast of the United States and Canada [after Olsen et al., 1996]. (c, d) Simplified geological map view and vertical cross sections of Newark Basin [after Schlische, 1992]. P and L are shallow and deepwater lacustrine...

  18. Omics of the mammalian gut New insights into function

    E-Print Network [OSTI]

    Lamendella, R.

    2013-01-01

    of beneficial bacteria as probiotics is a promising therapyof action of specific probiotics. “Omics” approaches haveKD: Clinical utility of probiotics in inflammatory bowel

  19. New insights on numerical error in symplectic integration

    E-Print Network [OSTI]

    Hugo Jiménez-Pérez; Jean-Pierre Vilotte; Barbara Romanowicz

    2015-08-13

    We implement and investigate the numerical properties of a new family of integrators connecting both variants of the symplectic Euler schemes, and including an alternative to the classical symplectic mid-point scheme, with some additional terms. This family is derived from a new method, introduced in a previous study, for generating symplectic integrators based on the concept of special symplectic manifold. The use of symplectic rotations and a particular type of projection keeps the whole procedure within the symplectic framework. We show that it is possible to define a set of parameters that control the additional terms providing a way of "tuning" these new symplectic schemes. We test the "tuned" symplectic integrators with the perturbed pendulum and we compare its behavior with an explicit scheme for perturbed systems. Remarkably, for the given examples, the error in the energy integral can be reduced considerably. There is a natural geometrical explanation, sketched at the end of this paper. This is the subject of a parallel article where a finer analysis is performed. Numerical results obtained in this paper open a new point of view on symplectic integrators and Hamiltonian error.

  20. agework@bc.edu 1 quick insight 7 | tpm

    E-Print Network [OSTI]

    Huang, Jianyu

    the effects of Human Resource Management (HRM) practices differ by age and gender? And, how do the effects of Time & Place Management (TPM) policies compare with those of other HRM policies? Based on an analysis, there has been a paradigm shift in how Human Resource Management (HRM) strategy is understood. The best

  1. New Insights into Light in the Oceans Tommy Dickey, UCSB

    E-Print Network [OSTI]

    Fabrikant, Sara Irina

    biogeochemistry (carbon dioxide) with optics c. Global climate change and ocean ecosystems #12;Fundamental Problem and apparent optical properties * Light absorption, scattering, polarization * Radiative transfer at air

  2. Strategic Insights From Playing the Quantum Tic-Tac-Toe

    E-Print Network [OSTI]

    J. N. Leaw; S. A. Cheong

    2010-07-21

    In this paper, we perform a minimalistic quantization of the classical game of tic-tac-toe, by allowing superpositions of classical moves. In order for the quantum game to reduce properly to the classical game, we require legal quantum moves to be orthogonal to all previous moves. We also admit interference effects, by squaring the sum of amplitudes over all moves by a player to compute his or her occupation level of a given site. A player wins when the sums of occupations along any of the eight straight lines we can draw in the $3 \\times 3$ grid is greater than three. We play the quantum tic-tac-toe first randomly, and then deterministically, to explore the impact different opening moves, end games, and different combinations of offensive and defensive strategies have on the outcome of the game. In contrast to the classical tic-tac-toe, the deterministic quantum game does not always end in a draw. In contrast also to most classical two-player games of no chance, it is possible for Player 2 to win. More interestingly, we find that Player 1 enjoys an overwhelming quantum advantage when he opens with a quantum move, but loses this advantage when he opens with a classical move. We also find the quantum blocking move, which consists of a weighted superposition of moves that the opponent could use to win the game, to be very effective in denying the opponent his or her victory. We then speculate what implications these results might have on quantum information transfer and portfolio optimization.

  3. Anthropological Insights in the Delivery of Health Services in Nepal

    E-Print Network [OSTI]

    Regmi, Rishikeshab Raj

    2001-01-01

    of Nepal are not given extra calories and proteins they require because of the belief that increased food intake during pregnancy results in larger babies culminating in difficult labour. In certain parts of rural Nepal infants are not generally given water... " that guides developmental interventions. While addressing the problem of getting planners to translate their concerns on to the understanding of local people, he stresses that policies calmot be successfully implemented and taken up by a people if they don...

  4. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    institutions, are breaking new ground in cellular biology through the application of neutron-scattering techniques. "Neutrons have advantages over other imaging probes, such...

  5. Designing for the 21st Interdisciplinary Question and Insights

    E-Print Network [OSTI]

    d'Inverno, Mark

    Mahdjoubi 68 The View of the Child: Explorations of the Visual Culture of the Made Environment Dr Catherine Stell, Prof. Lynne Cameron and Prof. Kenneth G. Hay 232 Discovery in Design: People and Dr David Smith, 246 Design Imaging Gordon M Mair and Kevin Miller 260 Sensory Design and its

  6. Radiation tolerance of nanocrystalline ceramics: Insights from yttria stabilized zirconia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dey, Sanchita; Drazin, John W.; Wang, Yongqiang; Valdez, James A.; Holesinger, Terry G.; Uberuaga, Blas P.; Castro, Ricardo H. R.

    2015-01-13

    Materials for applications in hostile environments, such as nuclear reactors or radioactive waste immobilization, require extremely high resistance to radiation damage, such as resistance to amorphization or volume swelling. Nanocrystalline materials have been reported to present exceptionally high radiation-tolerance to amorphization. In principle, grain boundaries that are prevalent in nanomaterials could act as sinks for point-defects, enhancing defect recombination. In this paper we present evidence for this mechanism in nanograined Yttria Stabilized Zirconia (YSZ), associated with the observation that the concentration of defects after irradiation using heavy ions (Kr?, 400 keV) is inversely proportional to the grain size. HAADF imagesmore »suggest the short migration distances in nanograined YSZ allow radiation induced interstitials to reach the grain boundaries on the irradiation time scale, leaving behind only vacancy clusters distributed within the grain. Because of the relatively low temperature of the irradiations and the fact that interstitials diffuse thermally more slowly than vacancies, this result indicates that the interstitials must reach the boundaries directly in the collision cascade, consistent with previous simulation results. Concomitant radiation-induced grain growth was observed which, as a consequence of the non-uniform implantation, caused cracking of the nano-samples induced by local stresses at the irradiated/non-irradiated interfaces.« less

  7. New insights into small-scale vertical distributions of phytoplankton

    E-Print Network [OSTI]

    Prairie, Jennifer Chan

    2011-01-01

    R. L. , J. G. Mitchell, and J. Seymour. 2003. GeostatisticalM. J. , L. Seuront, J. R. Seymour, N. L Patten, and J. G.M. J. , L. Seuront, J. R. Seymour, N. L Patten, and J. G.

  8. Smart Sensing Strategies: Insights from a Biological Active Sensing System

    E-Print Network [OSTI]

    Nelson, Mark E.

    of smart sensing systems in diverse engineering applications. Certain freshwater fish from South America and Africa, known as weakly electric fish, use self-generated electrical energy to actively probe their environment. The fish emit millivolt-level electrical discharges and detect microvolt-level voltage

  9. Public Interest Litigation: Insights from Theory and Practice

    E-Print Network [OSTI]

    Cummings, Scott L; Rhode, Deborah L.

    2009-01-01

    discourage funders and their grantees from taking on the “on engagement with their grantees but lack the expertise toup feedback from their grantees, those organi- zations will

  10. Technology Insights and Perspectives for Nuclear Fuel Cycle Concepts

    SciTech Connect (OSTI)

    S. Bays; S. Piet; N. Soelberg; M. Lineberry; B. Dixon

    2010-09-01

    The following report provides a rich resource of information for exploring fuel cycle characteristics. The most noteworthy trends can be traced back to the utilization efficiency of natural uranium resources. By definition, complete uranium utilization occurs only when all of the natural uranium resource can be introduced into the nuclear reactor long enough for all of it to undergo fission. Achieving near complete uranium utilization requires technologies that can achieve full recycle or at least nearly full recycle of the initial natural uranium consumed from the Earth. Greater than 99% of all natural uranium is fertile, and thus is not conducive to fission. This fact requires the fuel cycle to convert large quantities of non-fissile material into fissile transuranics. Step increases in waste benefits are closely related to the step increase in uranium utilization going from non-breeding fuel cycles to breeding fuel cycles. The amount of mass requiring a disposal path is tightly coupled to the quantity of actinides in the waste stream. Complete uranium utilization by definition means that zero (practically, near zero) actinide mass is present in the waste stream. Therefore, fuel cycles with complete (uranium and transuranic) recycle discharge predominately fission products with some actinide process losses. Fuel cycles without complete recycle discharge a much more massive waste stream because only a fraction of the initial actinide mass is burned prior to disposal. In a nuclear growth scenario, the relevant acceptable frequency for core damage events in nuclear reactors is inversely proportional to the number of reactors deployed in a fuel cycle. For ten times the reactors in a fleet, it should be expected that the fleet-average core damage frequency be decreased by a factor of ten. The relevant proliferation resistance of a fuel cycle system is enhanced with: decreasing reliance on domestic fuel cycle services, decreasing adaptability for technology misuse, enablement of material accountability, and decreasing material attractiveness.

  11. EM Gains Insight from Germany on Salt-Based Repositories

    Broader source: Energy.gov [DOE]

    KARLSRUHE and PEINE, Germany – EM officials recently took part in workshops in Germany to benefit from the exchange of research and experience operating salt-based repositories for radioactive waste.

  12. Social network theory: new insights and issues for behavioral ecologists

    E-Print Network [OSTI]

    Sih, Andrew; Hanser, Sean F.; McHugh, Katherine A.

    2009-01-01

    some can be considered keystone individuals); and (4) thatin the social network— keystone individuals Anecdotally, itintroduced the notion of a keystone individual drawn by

  13. Descended from Darwin Insights into the History of

    E-Print Network [OSTI]

    it was widely recognized that a dramatic increase in air pollution associated with the industrial revolution as the classic demonstration of natural selection, his pioneering field studies of the phenomenon of industrial the phenomenon of industrial melanism as an area of active inquiry, ignores the existence of alternative theories

  14. Exhumation Of The Peruvian Andes; Insights From Mineral Chronometers

    E-Print Network [OSTI]

    Michalak, Melanie

    2013-01-01

    N.I. , 1977. Reconnaissance geochronology of the crystallineClark, A.H. , 1981, K-Ar Geochronology of the Late CenozoicPuno, southeastern Peru: Geochronology and petrochemistry:

  15. Technology acquisition through collaboration: practical insights for technology suppliers

    E-Print Network [OSTI]

    Ortiz-Gallardo, Victor G.; Tietze, Frank; Probert, David R.; Phaal, Robert

    2015-01-05

    This paper describes the conditions that influence technology acquisition through collaboration. From the analysis of semi-structured interviews and eleven case studies, we developed a technology acquisition framework that stresses the supplier...

  16. Plasma Turbulence Simulations Reveal Promising Insight for Fusion...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Laboratory) With the potential to provide clean, safe, and abundant energy, nuclear fusion has been called the "holy grail" of energy production. But harnessing...

  17. Multiple Modeling Approaches and Insights for Critical Infrastructure Protection

    E-Print Network [OSTI]

    such as the Departments of Homeland Security, Energy and Transportation are responsible for the protection and regulation evolved toward economical and efficient systems that are robust against random failures and natural events protective measures, prepare for and assist in the response to natural disasters and unexpected disruptive

  18. Closer look at microorganism provides insight on carbon cycling | Argonne

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D BGene NetworkNuclearDNP 20082 P r o j e cLabLabNational

  19. Converting Methane to Methanol: Structural Insight into the Reaction Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit the followingConcentratingPortal ControllingConvection

  20. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation ofAlbuquerque|SensitiveAprilPhotonStructure of DNA-BoundFinanceStructures for

  1. EM Official Shares Insight at Women's Conference | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy A plug-inPPL EnergyPlus, LLCConfidentiality Agreement betweenSeptember 24,Regalbuto

  2. Nuclear magnetic resonance offers new insights into Pu 239

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shinesSolarNewsusceptometer under pressureNavy TurnsNuclear

  3. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shinesSolar Photovoltaic(MillionNature andNeutrinos fromdouble-betaNeutrons

  4. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shinesSolar Photovoltaic(MillionNature andNeutrinos

  5. New imaging technique provides improved insight into controlling the plasma

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shinesSolarNew scholarship supportsFeet) Underground StorageNewNewstate

  6. ALS Gives Chevron Scientists New Insights into Corrosion Resistance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.TheoryTuesday, August 10, 20102016 News BelowAskedAIKENALSDoctoral FellowshipALS

  7. Physics of Reliability: Evaluating Design Insights for Component

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy AEnergyPresidential PermitDAYS - WE NEED ADr. PeterPV), or solar

  8. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES October 27th,Environmental StewardshipStoriesEnvironmentalEnzyme

  9. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES October 27th,Environmental

  10. Ecofys-Nationally Appropriate Mitigation Actions: Insights from Example

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:of the NationalDynetekof EconomicEcodasa

  11. Physics of Reliability: Evaluating Design Insights for Component

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCTCriticalEnergySiliconDepartment(PARTI).

  12. Physics of Reliability: Evaluating Design Insights for Component

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1,

  13. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect PhotovoltaicsStructure and Receptorsurvivor 8 StructureStructures

  14. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect PhotovoltaicsStructure and Receptorsurvivor 8

  15. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect PhotovoltaicsStructure and Receptorsurvivor 8Structures for Three

  16. Structures for Three Membrane Transport Proteins Yield Functional Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect PhotovoltaicsStructure and Receptorsurvivor 8Structures for

  17. Selecting Solar: Insights into Residential Photovoltaic (PV) Quote Variation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust, High-ThroughputUpcomingmagnetoresistanceand Governmentm D(SC) SeeingSelecting Solar:

  18. Plasma Turbulence Simulations Reveal Promising Insight for Fusion Energy |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass mapSpeeding access| DepartmentPeerFederal FleetUpSmall WindPrincetonPlasma

  19. Worldwide Trends in Energy Use and Efficiency: Key Insights from

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EAand Dalton Jump to: navigation,WoodInformation

  20. Bob Jaffe, Massachusetts Institute of Technology, Insights from the Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De pEnergy Industrial LocalApril 15,DepartmentCritical

  1. Crystal Structures of Phosphite Dehydrogenase Provide Insights into

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing BacteriaConnect Collider TestspolycarbonateArticle) |034Replace FossilNicotinamide

  2. Atomistic insights into aqueous corrosion of copper. (Journal Article) |

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing Bacteria (Technical Report) | SciTech Connect AssessingBasinLecture)SciTech

  3. Metagenomic Insights into Evolution of a Heavy Metal-Contaminated

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(JournalspectroscopyReport) | SciTechelement methodbyoxideLagrangeLarsen and

  4. Metagenomic Insights into Evolution of a Heavy Metal-Contaminated

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing(JournalspectroscopyReport) | SciTechelement methodbyoxideLagrangeLarsen andGroundwater

  5. Voices of Experience | Insights into Advanced Distribution Management

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyThe U.S.Lacledeutilities. TheEnergyEnergy mostJeff Erickson willSystems

  6. Structural insights into [mu]-opioid receptor activation (Journal Article)

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail. (Conference)Feedback System inStatus of theSciTechin a diiron enzymeabsorption|

  7. Sue Cange Provides Insight on Oak Ridge's Cleanup Progress, Partnerships

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutory Authority for anStudy: Algae CouldSubstanceRainey STAROil|

  8. Insights from Smart Meters: Identifying Specific Actions, Behaviors, and

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergy HeadquartersFuelBConservationEnergy Innovative Software TacklesCharacteristics That

  9. Voices of Experience: Insights on Smart Grid Customer Engagement (July

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematics And Statistics » USAJobs Search USAJobsAdvancedVeteran LeadershipVision for09 DOE2013) |

  10. Voices of Experience: New Guide Offers Utilities' Insights on Engaging

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OF APPLICABLEStatutoryinEnableVisualization & Controls ProgramInsightswith

  11. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D. Title: ProfessorHigh-Pressure MOF Research Yields

  12. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D. Title: ProfessorHigh-Pressure MOF Research

  13. Insight into Alzheimer's, cancer, anemia gleaned from ribosome research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATION PLANIs gravity a particle or aHowInside the Crystal

  14. Katharine Page: Atomic-level insights for better materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousand Cubic Feet) Sold to CommercialKate Bannan About Us

  15. Intern Shares Insight Into Researchers' Minds |GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenryInhibitingInteractive Jobs Interactive JobsInterlibrary LoanThe

  16. Katharine Page-Atomic-level insights for better materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate student Subtask 4Photo4 | NationalAbout

  17. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutron ComputedHigh-PerformanceHigh-Pressure MOF

  18. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutron ComputedHigh-PerformanceHigh-Pressure

  19. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutron

  20. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutronHigh-Pressure MOF Research Yields Structural

  1. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutronHigh-Pressure MOF Research Yields

  2. High-Pressure MOF Research Yields Structural Insights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energy neutronHigh-Pressure MOF Research YieldsHigh-Pressure

  3. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy ServicesEnergy InnovationEnzyme Structure

  4. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy ServicesEnergy InnovationEnzyme StructureEnzyme

  5. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy ServicesEnergy InnovationEnzyme

  6. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy ServicesEnergy InnovationEnzymeEnzyme Structure

  7. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansasCommunitiesof Energy ServicesEnergy InnovationEnzymeEnzyme

  8. Ribosome research in atomic detail offers potential insights into cancer,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) byMultiday ProductionDesigningResources Thomas» Reveal

  9. Deep Insights from Thin Layers | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann JacksonDepartment ofOffice ofof Energy Brad BuggerOIGM. Klaus -Banking DeclarationThe

  10. Sandia National Laboratories: Global Insight, Inc. / Department of Labor

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)GeothermalFuelInnovationScienceElectromagneticsNews Releases

  11. Solar wind samples give insight into birth of solar system

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation ofAlbuquerque|Sensitive Species3performedValley |Solar PowerofThermalSolar

  12. Sandia Energy - Computational Fluid Dynamics Simulations Provide Insight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) byMultidayAlumniProjects Caterpillar, SandiaCombustion Kineticsfor

  13. Proteins' Amazing Origami Powers: Insight for Potential Disease Treatments

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram: Report Appendices |Project Management| Department of Energy

  14. Making Sustainable Energy Choices: Insights on the Energy/Water/Land Nexus (Technical Report), Analysis Insights, NREL (National Renewable Energy Laboratory)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse BergkampCentermillion toMSDS on theMaitrayeeEnergy

  15. Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean

    E-Print Network [OSTI]

    Crook, Elizabeth Derse

    2015-01-01

    rapidly overgrown by fleshy algae in acidified conditions;interactions between fleshy algae and calcifying speciessuggests that non-calcareous algae appear to benefit in low

  16. August 2010 |Vol.7 No.4 Providing Insight, Understanding and Community

    E-Print Network [OSTI]

    Kim, Duck O.

    management who have been key in our efforts to engage staff. JHC: What is the most important quality you look for imaging services, cardiac services and supply chain operations Lifespan, Providence, R.I. Five hospitals management University of Connecticut Health Center, John Dempsey Hospital, Farmington, Conn. Thomas M

  17. TwitterHitter: Geovisual Analytics for Harvesting Insight from Volunteered Geographic Information

    E-Print Network [OSTI]

    Klippel, Alexander

    and geovisual analytics. Volunteered geographic information (VGI) describes the collection and maintenance in the landscape that reveal and explain the changing conditions surrounding them (Goodchild 2007a, 2007b). VGI by the VGI produced by microblogging (Starbird et al. 2010). 3. TwitterHitter TwitterHitter (Figure 1

  18. Theory of Current Transients in Planar Semiconductor Devices: Insights and Applications to Organic Solar Cells

    E-Print Network [OSTI]

    Hawks, SA; Finck, BY; Schwartz, BJ

    2015-01-01

    Dyakonov, Organic solar cell efficiencies under the aspectfor low-cost, high-efficiency solar cells, J. Phys. Chem.dependent efficiencies of organic bulk heterojunction solar

  19. Electronic processes in organic optoelectronics : insights gained through modeling and magnetic field effects

    E-Print Network [OSTI]

    Hontz, Eric Richard

    2015-01-01

    Organic photovoltaics (OPVs) and organic light-emitting diodes (LEDs) are organic optoelectronics offering a number of unique benefits that may play an important role in the future of clean energy generation and efficient ...

  20. Structural Insights into the Cooperative Binding of SeqA to a Tandem GATC Repeat

    SciTech Connect (OSTI)

    Chung, Y.; Brendler, T; Austin, S; Guarne, A

    2009-01-01

    SeqA is a negative regulator of DNA replication in Escherichia coli and related bacteria that functions by sequestering the origin of replication and facilitating its resetting after every initiation event. Inactivation of the seqA gene leads to unsynchronized rounds of replication, abnormal localization of nucleoids and increased negative superhelicity. Excess SeqA also disrupts replication synchrony and affects cell division. SeqA exerts its functions by binding clusters of transiently hemimethylated GATC sequences generated during replication. However, the molecular mechanisms that trigger formation and disassembly of such complex are unclear. We present here the crystal structure of a dimeric mutant of SeqA [SeqA{Delta}(41-59)-A25R] bound to tandem hemimethylated GATC sites. The structure delineates how SeqA forms a high-affinity complex with DNA and it suggests why SeqA only recognizes GATC sites at certain spacings. The SeqA-DNA complex also unveils additional protein-protein interaction surfaces that mediate the formation of higher ordered complexes upon binding to newly replicated DNA. Based on this data, we propose a model describing how SeqA interacts with newly replicated DNA within the origin of replication and at the replication forks.

  1. Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders

    E-Print Network [OSTI]

    Kim, YS; Leventhal, BL

    2015-01-01

    Most genetic risk for autism resides with common variation.in the pathogenesis of autism. Cell 155: Kim YS, State MW (retarded patients without autism and in normal individuals.

  2. Insight into the Structure of Light Harvesting Complex II and its Stabilization in Detergent Solution

    SciTech Connect (OSTI)

    Cardoso, Mateus B [ORNL; Smolensky, Dmitriy [ORNL; Heller, William T [ORNL; O'Neill, Hugh Michael [ORNL

    2009-01-01

    The structure of spinach light-harvesting complex II (LHC II), stabilized in a solution of the detergent n-octyl-{beta}-d-glucoside (BOG), was investigated by small-angle neutron scattering (SANS). Physicochemical characterization of the isolated complex indicated that it was pure (>95%) and also in its native trimeric state. SANS with contrast variation was used to investigate the properties of the protein-detergent complex at three different H{sub 2}O/D{sub 2}O contrast match points, enabling the scattering properties of the protein and detergent to be investigated independently. The topological shape of LHC II, determined using ab initio shape restoration methods from the SANS data at the contrast match point of BOG, was consistent with the X-ray crystallographic structure of LHC II (Liu et al. Nature 2004 428, 287-292). The interactions of the protein and detergent were investigated at the contrast match point for the protein and also in 100% D{sub 2}O. The data suggested that BOG micelle structure was altered by its interaction with LHC II, but large aggregate structures were not formed. Indirect Fourier transform analysis of the LHC II/BOG scattering curves showed that the increase in the maximum dimension of the protein-detergent complex was consistent with the presence of a monolayer of detergent surrounding the protein. A model of the LHC II/BOG complex was generated to interpret the measurements made in 100% D{sub 2}O. This model adequately reproduced the overall size of the LHC II/BOG complex, but demonstrated that the detergent does not have a highly regular shape that surrounds the hydrophobic periphery of LHC II. In addition to demonstrating that natively structured LHC II can be produced for functional characterization and for use in artificial solar energy applications, the analysis and modeling approaches described here can be used for characterizing detergent-associated {alpha}-helical transmembrane proteins.

  3. New insights into microbial responses to oil spills from the Deepwater Horizon incident

    SciTech Connect (OSTI)

    Mason, O.U.; Hazen, T.C.

    2011-06-15

    On April 20, 2010, a catastrophic eruption of methane caused the Deepwater Horizon exploratory drill rig drilling the Macondo Well in Mississippi Canyon Block 252 (MC252) to explode. The Deepwater Horizon oil spill was unprecendeted for several reasons: the volume of oil released; the spill duration; the well depth; the distance from the shore-line (77 km or about 50 miles); the type of oil (light crude); and the injection of dispersant directly at the wellhead. This study clearly demonstrated that there was a profound and significant response by certain members of the in situ microbial community in the deep-sea in the Gulf of Mexico. In particular putative hydrocarbon degrading Bacteria appeared to bloom in response to the Deepwater Horizon oil spill, even though the temperature at these depths is never >5 C. As the plume aged the shifts in the microbial community on a temporal scale suggested that different, yet metabolically important members of the community were able to respond to a myriad of plume constituents, e.g. shifting from propane/ethane to alkanes and finally to methane. Thus, the biodegradation of hydrocarbons in the plume by Bacteria was a highly significant process in the natural attenuation of many compounds released during the Deepwater Horizon oil spill.

  4. Structural insight into the assembly of iron-sulfur clusters and their function in radical generation

    E-Print Network [OSTI]

    Vey, Jessica L. (Jessica Lynn)

    2008-01-01

    This thesis addresses two emerging areas in the study of iron-sulfur cluster biochemistry: bioassembly of iron-sulfur clusters, and their involvement in initiation of radical chemistry. The structure of a cysteine desulfurase ...

  5. Linking ArcView 3.0TM and XGobi: Insight Behind the Front End

    E-Print Network [OSTI]

    Symanzik, Jürgen

    of the implementation of a bidirectional link between the Geographic Information System GIS ArcView 3.0TM; Geographic information system; Imple- mentation issues; Spatial cumulative distribution function; Spatial statistics; Spatially lagged scatterplot; Variogram cloud plot. 1 Introduction Geographic Information Systems

  6. Linking ArcView 3.0TM and XGobi: Insight Behind the Front End

    E-Print Network [OSTI]

    Symanzik, Jürgen

    of a bidirectional link between the Geographic Information System (GIS) ArcView 3.0TM and the interactive dynamic Information Systems (GISs) are used extensively for examining spa- tial data but, traditionally, they have few tools necessary for displaying geographic information. The lack of ex- ploratory tools in a GIS

  7. Soft matter and fractional mathematics: insights into mesoscopic quantum and time-space structures

    E-Print Network [OSTI]

    mesoscopic quantum mechanics and time-space structures governing "anomalous" behaviors of soft matter. Our and space. But the theory does not hold at the microscopic subatomic level, where quantum mechanics theory-known soft matter are polymers, colloids, emulsions, foams, living organisms, rubber, oil, soil, other porous

  8. New insights into the decay of ion waves to turbulence, ion heating, and soliton generation

    SciTech Connect (OSTI)

    Chapman, T. Banks, J. W.; Berger, R. L.; Cohen, B. I.; Williams, E. A.; Brunner, S.

    2014-04-15

    The decay of a single-frequency, propagating ion acoustic wave (IAW) via two-ion wave decay to a continuum of IAW modes is found to result in a highly turbulent plasma, ion soliton production, and rapid ion heating. Instability growth rates, thresholds, and sensitivities to plasma conditions are studied via fully kinetic Vlasov simulations. The decay rate of IAWs is found to scale linearly with the fundamental IAW potential amplitude ?{sub 1} for ZT{sub e}/T{sub i}?20, beyond which the instability is shown to scale with a higher power of ?{sub 1}, where Z is the ion charge number and T{sub e} (T{sub i}) is the electron (ion) thermal temperature. The threshold for instability is found to be smaller by an order of magnitude than linear theory estimates. Achieving a better understanding of the saturation of stimulated Brillouin scatter levels observed in laser-plasma interaction experiments is part of the motivation for this study.

  9. New insights into the nature of the peculiar star theta Carinae

    E-Print Network [OSTI]

    S. Hubrig; M. Briquet; T. Morel; M. Schoeller; J. F. Gonzalez; P. De Cat

    2008-07-13

    We acquired high resolution spectroscopic and low resolution spectropolarimetric observations to achieve the following goals: a) to improve the orbital parameters to allow a more in-depth discussion on the possibility of mass transfer in the binary system, b) to carry out a non-local thermodynamic equilibrium (NLTE) abundance analysis, and c) to search for the presence of a magnetic field. The study of the radial velocities using CORALIE spectra allowed us to significantly improve the orbital parameters. A comparative NLTE abundance analysis was undertaken for theta Car and two other early B-type stars with recently detected magnetic fields, tau Sco and xi^1 CMa. The analysis revealed significantly different abundance patterns: a one-order-of-magnitude nitrogen overabundance and carbon depletion was found in theta Car, while the oxygen abundance is roughly solar. For the stars xi^1 CMa and tau Sco the carbon abundance is solar and, while an N excess is also detected, it is of much smaller amplitude (0.4-0.6dex). Such an N overabundance is typical of the values already found for other slowly-rotating (magnetic) B-type dwarfs. For theta Car, we attribute instead the chemical peculiarities to a past episode of mass transfer between the two binary components. The results of the search for a magnetic field using FORS1 at the VLT consisting of 26 measurements over a time span of ~1.2h are rather inconclusive: only few measurements have a significance level of 3sigma. Although we detect a periodicity of the order of ~8.8min in the dataset involving the measurements on all hydrogen Balmer lines with the exception of the Halpha and Hbeta lines, these results have to be confirmed by additional time-resolved magnetic field observations.

  10. How much potassium is in the Earth's core? New insights from partitioning experiments

    E-Print Network [OSTI]

    Mcdonough, William F.

    of the magnetic field and convection in the outer core and mantle are intimately linked to the amount of heat) that are potentially present in the core. In the absence of radioactive heating, predicted high rates of core present in the core. In addition to primordial heat, the latent heat of crystallization of the inner core

  11. Origin of resolution enhancement by co-doping of scintillators: Insight from electronic structure calculations

    SciTech Connect (OSTI)

    Åberg, Daniel, E-mail: aberg2@llnl.gov; Sadigh, Babak [Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Schleife, André [Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Erhart, Paul, E-mail: erhart@chalmers.se [Department of Applied Physics, Chalmers University of Technology, Gothenburg (Sweden)

    2014-05-26

    It was recently shown that the energy resolution of Ce-doped LaBr{sub 3} scintillator radiation detectors can be crucially improved by co-doping with Sr, Ca, or Ba. Here, we outline a mechanism for this enhancement on the basis of electronic structure calculations. We show that (i) Br vacancies are the primary electron traps during the initial stage of thermalization of hot carriers, prior to hole capture by Ce dopants; (ii) isolated Br vacancies are associated with deep levels; (iii) Sr doping increases the Br vacancy concentration by several orders of magnitude; (iv) Sr{sub La} binds to V{sub Br} resulting in a stable neutral complex; and (v) association with Sr causes the deep vacancy level to move toward the conduction band edge. The latter is essential for reducing the effective carrier density available for Auger quenching during thermalization of hot carriers. Subsequent de-trapping of electrons from Sr{sub La}–V{sub Br} complexes can activate Ce dopants that have previously captured a hole leading to luminescence. This mechanism implies an overall reduction of Auger quenching of free carriers, which is expected to improve the linearity of the photon light yield with respect to the energy of incident electron or photon.

  12. Transport coefficients of strongly coupled gauge theories: insights from string theory

    E-Print Network [OSTI]

    Andrei O. Starinets

    2005-11-26

    The transport properties of certain strongly coupled thermal gauge theories can be determined from their effective description in terms of gravity or superstring theory duals. Here we provide a short summary of the results for the shear and bulk viscosity, charge diffusion constant, and the speed of sound in supersymmetric strongly interacting plasmas. We also outline a general algorithm for computing transport coefficients in any gravity dual. The algorithm relates the transport coefficients to the coefficients in the quasinormal spectrum of five-dimensional black holes in asymptotically anti de Sitter space.

  13. Insights on postinjection-associated soot emissions in direct injection diesel engines

    SciTech Connect (OSTI)

    Arregle, Jean; Pastor, Jose V.; Lopez, J. Javier; Garcia, Antonio [CMT-Motores Termicos, Universidad Politecnica de Valencia, Camino de Vera, s/n 46022, Valencia (Spain)

    2008-08-15

    A comprehensive study was carried out in order to better understand combustion behavior in a direct injection diesel engine when using postinjections. More specifically, the aim of the study is twofold: (1) to better understand the mechanism of a postinjection to reduce soot and (2) to improve the understanding of the contribution of the postinjection combustion on the total soot emissions by looking at the effect of the postinjection timing variation and the postinjection mass variation on the soot emissions associated with the postinjection. The study is focused only on far postinjections, and the explored operating conditions include the use of EGR. The first objective was fulfilled analyzing some results from a previous work adding only a few complementary results. Concerning the second objective, the basic idea behind the analysis performed is the search of appropriate parameters physically linked to the processes under analysis. These parameters are found based on the state-of-the-art of diesel combustion. For the effect of the postinjection timing, the physical parameter found was the temperature of the unburned gases at the end of injection, T{sub ug{sub E}}{sub oI}. It was checked that a threshold level of T{sub ug{sub E}}{sub oI} ({proportional_to}700 K for the cases explored here) exists below which soot is unable to be formed, independently of the postinjection size, and the amount of soot increases as the temperature increases beyond this threshold. For the effect of the postinjection size, the physical parameter that was found was DoI/ACT (the ratio between the actual duration of injection and the time necessary for mixing - the apparent combustion time). This parameter can quantify when the postinjection is able to produce soot (the threshold value is {proportional_to}0.37 for the cases explored here), and the amount of soot produced increases as this parameter increases beyond this threshold value. A function containing these two parameters has been fitted to the experimental soot emissions associated with the postinjection obtained in many engine operating conditions, and the appropriate quality of the fit demonstrates that these two parameters explain the main behaviors of the soot emissions associated with a postinjection. (author)

  14. Insights into Endosymbiont-mediated Defense of Drosophila Flies Against Parasitoid Wasps 

    E-Print Network [OSTI]

    Xie, Jialei

    2013-08-27

    , Sarah Butler, Grecia Sanchez, Lauryn Winter and Caitlyn Winter. Thanks also go to the faculty and staff of the Department of Wildlife and Fisheries Sciences for making my time at Texas A&M University a great experience. I also want to extend my...

  15. Developing effective chronic disease interventions in Africa: insights from Ghana and Cameroon

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Boynton, Petra; Atanga, Lem L.

    2010-04-19

    - vant to secondary prevention. Sedentary lifestyles have been strongly implicated in Ghana's chronic disease burden [45]. However there is also an emerging keep-fit culture in urban and rural fit and football clubs are also common across the country...

  16. Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism

    E-Print Network [OSTI]

    the efficiency of energy usage in industrial algal farming (Fernandes et al, 2010). Light spectral quality also, Boston, MA, USA, 3 Department of Genetics, Harvard Medical School, Boston, MA, USA, 4 Department

  17. Forest fire management in Portugal : developing system insights through models of social and physical dynamics

    E-Print Network [OSTI]

    Collins, Ross D. (Ross Daniel)

    2012-01-01

    Managing forest fires is a serious national problem in Portugal. Burned area has increased steadily over the past several decades, with particularly devastating years in 2003 and 2005. Ignitions also spike dramatically in ...

  18. Theory of Current Transients in Planar Semiconductor Devices: Insights and Applications to Organic Solar Cells

    E-Print Network [OSTI]

    Hawks, SA; Finck, BY; Schwartz, BJ

    2015-01-01

    conduction in organic photovoltaic cells at open-circuitin TiO 2 =dye=CuSCN photovoltaic cells explored by recombi-of TiO 2 =dye=CuSCN photovoltaic cells, J. Phys. Chem. B

  19. INSIGHTS | PERSPECTIVES 1092 6 JUNE 2014 VOL 344 ISSUE 6188 sciencemag.org SCIENCE

    E-Print Network [OSTI]

    Napp, Nils

    with electrons from H2 to make acetate and methane, re- spectively. They use a chemical mechanism called flavin-based-releasing chemical reactions are at the core of the living process of all organisms. These bioenergetic reac- tions that early life harnessed energy from volcanic pyrite syn- thesis (2), zinc sulfide­based photosynthesis (3

  20. New insights into the chemical composition of chitinozoans Jrmy Jacob1,

    E-Print Network [OSTI]

    Boyer, Edmond

    . More recent work has shown that the degradation of chitin tissues occurs during early diagenesis (Baas

  1. Quantum Insights in Gate Oxide Charge-Trapping Dynamics in Nanoscale MOSFETs

    E-Print Network [OSTI]

    Dimov, Ivan

    , in this paper we investigate the trapping of a single electron in the gate oxide of a 25nm transistor including and scattering phenomena. Keywords--Reliability; Tunneling; Scattering; NBTI; RTN; Wigner Function; charge-trapping. The evolution of an initial electron packet subject to the action of device channel potential and the oxide trap

  2. Porosity of coal and shale: Insights from gas adsorption and SANS/USANS techniques

    SciTech Connect (OSTI)

    Mastalerz, Maria; He, Lilin; Melnichenko, Yuri B; Rupp, John A

    2012-01-01

    Two Pennsylvanian coal samples (Spr326 and Spr879-IN1) and two Upper Devonian-Mississippian shale samples (MM1 and MM3) from the Illinois Basin were studied with regard to their porosity and pore accessibility. Shale samples are early mature stage as indicated by vitrinite reflectance (R{sub o}) values of 0.55% for MM1 and 0.62% for MM3. The coal samples studied are of comparable maturity to the shale samples, having vitrinite reflectance of 0.52% (Spr326) and 0.62% (Spr879-IN1). Gas (N{sub 2} and CO{sub 2}) adsorption and small-angle and ultrasmall-angle neutron scattering techniques (SANS/USANS) were used to understand differences in the porosity characteristics of the samples. The results demonstrate that there is a major difference in mesopore (2-50 nm) size distribution between the coal and shale samples, while there was a close similarity in micropore (<2 nm) size distribution. Micropore and mesopore volumes correlate with organic matter content in the samples. Accessibility of pores in coal is pore-size specific and can vary significantly between coal samples; also, higher accessibility corresponds to higher adsorption capacity. Accessibility of pores in shale samples is low.

  3. Evaluating an InfoVis Technique Using Insight Reports Markus Rester1

    E-Print Network [OSTI]

    on the results of the questionnaires, and, more generally, to analyze the factors influencing anorexia nervosa

  4. New insights in dynamic modeling of a secondary settler--I.

    E-Print Network [OSTI]

    Pacard, Frank

    of a wastewater treatment plant is given by a nonlinear scalar conservation law for the sludge concen- tration, secondary settler, thick- ening, waste water treatment plant. 1 Nomenclature A(x) = area of the settler flow (L3 T-1 ) Qi = inflow to treatment plant (from aeration tank) (L3 T-1 ) Qf = inflow to settler (L3

  5. insight review articles NATURE | VOL 409 | 11 JANUARY 2001 | www.nature.com 253

    E-Print Network [OSTI]

    Arnold, Frances H.

    and intricately structured molecules that ward off predators or attract mates. Such catalysts are models of energy-efficient are masterful chemists -- a fact long appreciated by those who study how living things build complex molecules

  6. Energy, the Environment and Behaviour Change: A survey of insights from behavioural economics

    E-Print Network [OSTI]

    Baddeley, Michelle

    using optical sorting technology and then recombining the plastics to make plastic pellets. The energy and processing costs are significantly lower because recycled plastic manufacture is not a drain on natural resources espe- cially oil... energy; potential efficiency gains can be made within businesses too. Figure 4 shows US estimates of rises in energy consumption from 2008 to 2035 and shows that energy consumption in the industrial / commercial and transportation sectors overwhelms...

  7. Insight into the Genetic Basis of Craniofacial Morphological Variation in the Domestic Dog, Canis familiaris

    E-Print Network [OSTI]

    Rizk, Oliver Torres

    2012-01-01

    und Körpergrösse. Zool. Anz. 155: 215-232. Klatt, B. 1955b.of the dog. Anat. Anz. 186(4): 323-330. American Kenneldes Haushundes. Zool. Anz. Jena 192: 383-413. Lüps, P. and

  8. Phylogenetic relationships of flowerpeckers (Aves: Dicaeidae): Novel insights into the evolution of a tropical passerine clade

    E-Print Network [OSTI]

    Nyá ri, Á rpá d S.; Peterson, A. Townsend; Rice, Nathan H.; Moyle, Robert G.

    2009-12-01

    extracted from toe pads. Taxon#7;Voucher source1#7;Sample ##7;Locality#7;TGFb2#7;ND2#7;ND3#7;#7;Ingroup#7;#7;#7;#7;#7;#7;#7;#7;Dicaeum aeneum#7;AMNH#7;DOT 6657#7;Solomon Islands, Isabel Island#7;GQ145327#7;GQ145285#7;GQ145243#7;#7;Dicaeum anthonyi#7;FMNH#7...;429296#7;Philippines, Luzon, Kalinga#7;GQ145325#7;GQ145283#7;GQ145241#7;#7;Dicaeum agile *#7;WFVZ#7;41288#7;Malaysia, Sabah, Tawau#7;GQ145348#7;GQ145306#7;GQ145264#7;#7;Dicaeum aureolimbatum#7;AMNH#7;DOT 12599#7;Indonesia, Sulawesi, Poso#7;GQ145330#7;GQ145288#7;GQ...

  9. Molecular Evolution of Lepidopteran Silk Proteins: Insights from the Ghost Moth, Hepialus californicus

    E-Print Network [OSTI]

    Collin, Matthew A.; Mita, Kazuei; Sehnal, Frantisek; Hayashi, Cheryl Y.

    2010-01-01

    Rhy obl; AB354588) (dragline silk) ?broin has also beenthe C-terminal domain of a dragline spider silk protein in

  10. Structure-Function Analysis of Apolipoprotein A-V: Insight into Plasma Triglyceride Homeostasis

    E-Print Network [OSTI]

    Mauldin, Kasuen

    2010-01-01

    spectroscopy Far UV CD measurements were performed on aCD) spectroscopy Far UV CD spectroscopy measurements weremeasurements were performed on an AVIV 410 spectrophotometer. Far UV

  11. §1603 Treasury Grant Expiration. Industry Insight on Financing and Market Implications

    SciTech Connect (OSTI)

    Mendelsohn, Michael; Harper, John

    2012-06-01

    This study explores the likely project financing and market impacts from the expiration of the §1603 Program.

  12. Disease in Natural Plant Populations, Communities, and Ecosystems: Insights into Ecological and Evolutionary Processes

    E-Print Network [OSTI]

    Alexander, Helen M.

    2010-05-01

    for a pathogen can lead to par- ticularly interesting effects if one or more plant species harbors the pathogen but is not greatly impacted. As noted by Haldane, “a non- specific parasite…is a powerful competitive weapon” (58). For example, infected... multiple approaches. For example, Mitchell and Power (85) ex- plored the use of pathogen databases and concluded that 84% fewer fungal pathogens and 24% fewer virus species infect plant species in their naturalized ranges in North America than...

  13. Lithospheric mantle evolution in the Afro-Arabian domain: Insights from Bir Ali mantle xenoliths (Yemen)

    E-Print Network [OSTI]

    Graham, David W.

    the complex mantle dynamics of a region that after Oligocene continental flood basalt (CFB) magmatism is generally called upon to explain the voluminous, chemically distinct CFB magmatism in the region, the plume

  14. Water Vapor Variability Across Spatial Scales: Insights for Theory, Parameterization, and Model Assessment

    E-Print Network [OSTI]

    Pressel, Kyle Gregory

    2012-01-01

    map of outgoing longwave radiation is a map of the effectivegoing shortwave radiation is essentially a map of surfaceshows the map of TOA outgoing shortwave radiation with the

  15. October 19, 2010 1 Introduction to Reporting Using Digital Measures Activity Insight

    E-Print Network [OSTI]

    Bieber, Michael

    and Professional Positions · Appointments outside NJIT · Administrative Assignments · NJIT administrative or Examples General Information · Personal and Contact Information · Administrative Data Permanent Data assignments (e.g. Chairperson, Graduate Advisor, Program Director, Research Center Administration) · Awards

  16. A Korarchael Genome Reveals Insights into the Evolution of the Archaea

    E-Print Network [OSTI]

    Elkins, James G.

    2008-01-01

    bioenergetics in the Yellowstone geothermal ecosystem. Procbioenergetics in the Yellowstone geothermal ecosystem. Proc2005) in Geothermal Biology and Geochemstry in Yellowstone

  17. New insights into the enigma of boron carbide inverse molecular behavior

    SciTech Connect (OSTI)

    Dera, Przemyslaw; Manghnani, Murli H.; Hushur, Anwar; Hu, Yi; Tkachev, Sergey

    2014-07-01

    Equation of state and compression mechanism of nearly stoichiometric boron carbide B{sub 4}C were investigated using diamond anvil cell single crystal synchrotron X-ray diffraction technique up to a maximum quasi-hydrostatic pressure of 74.0(1) GPa in neon pressure transmitting medium at ambient temperature. No signatures of structural phase transitions were observed on compression. Crystal structure refinements indicate that the icosahedral units are less compressible (13% volume reduction at 60 GPa) than the unit cell volume (18% volume reduction at 60 GPa), contrary to expectations based on the inverse molecular behavior hypothesis, but consistent with spectroscopic evidence and first principles calculations. The high-pressure crystallographic refinements reveal that the nature of the chemical bonds (two, versus three centered character) has marginal effect on the bond compressibility and the compression of the crystal is mainly governed by the force transfer between the rigid icosahedral structural units. - Graphical abstract: Single crystal measurements of equation of state and compression mechanism of B{sub 4}C show that the icosahedral units are less compressibe than the unit cell volume, despite the threei-ceneterd nature of some icosahedral bonds. - Highlights: • Equation of state and compression mechanism of B{sub 4}C were measured to 75 GPa. • No signatures of structural phase transitions were observed on compression. • Icosahedral units are less compressibe than the unit cell volume. • The nature of the chemical bonds has mariginal effect on the bond compressibility. • The compression is governed by force transfer between the rigid icosahedra.

  18. NMR Insights into Folding and Self-Association of Plasmodium falciparum P2

    E-Print Network [OSTI]

    Sharma, Shobhona

    Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India, 2 Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India, 3 Department of Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, India, 4 UM-DAE Centre for Excellence in Basic

  19. Metagenomic Insights into Evolution of a Heavy Metal-Contaminated Groundwater Microbial Community

    E-Print Network [OSTI]

    Hemme, Christopher L.

    2010-01-01

    gradient under acidic conditions can be achieved by modulation of the intracellular pH via metabolism

  20. Revisiting shock-driven exploding pushers: Insights into plasma flows and fields, stopping power, nucleosynthesis, and

    E-Print Network [OSTI]

    pusher (a), and the magnet-based, charged-particle spectrometer CPS-2 [9] used to measure them (b). CPS-2 monoenergetic 3.0-MeV protons, 14.7-MeV protons, and 3.6-MeV alphas, which are used to "backlight" a wide collisions; in magnetic reconnection; in Rayleigh-Taylor instability growth; and in direct- and indirect

  1. Structural studies of bacterial multicomponent monooxygenases : insights into substrate specificity, diiron center tuning and component interactions

    E-Print Network [OSTI]

    Sazinsky, Matthew H. (Matthew Howard), 1976-

    2004-01-01

    (cont.) ?-subunit cavities. The presence of 6-bromohexan-l-ol induces one of the active site helices to adopt a [pi] conformation. Together, these findings suggest modes by which molecules may move through the MMOH cavities ...

  2. Molecular Chemistry to the Fore: New Insights into the Fascinating World of Photoactive Colloidal Semiconductor Nanocrystals

    SciTech Connect (OSTI)

    Vela-Becerra, Javier

    2013-02-01

    Colloidal semiconductor nanocrystals possess unique properties that are unmatched by other chromophores such as organic dyes or transition-metal complexes. These versatile building blocks have generated much scientific interest and found applications in bioimaging, tracking, lighting, lasing, photovoltaics, photocatalysis, thermoelectrics, and spintronics. Despite these advances, important challenges remain, notably how to produce semiconductor nanostructures with predetermined architecture, how to produce metastable semiconductor nanostructures that are hard to isolate by conventional syntheses, and how to control the degree of surface loading or valence per nanocrystal. Molecular chemists are very familiar with these issues and can use their expertise to help solve these challenges. In this Perspective, we present our group’s recent work on bottom-up molecular control of nanoscale composition and morphology, low-temperature photochemical routes to semiconductor heterostructures and metastable phases, solar-to-chemical energy conversion with semiconductor-based photocatalysts, and controlled surface modification of colloidal semiconductors that bypasses ligand exchange.

  3. Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean

    E-Print Network [OSTI]

    Crook, Elizabeth Derse

    2015-01-01

    Unidad de Ciencias del Agua (UCIA), Centro de InvestigaciónUnidad de Ciencias del Agua (UCIA), Centro de InvestigaciónUnidad de Ciencias del Agua (UCIA), Centro de Investigación

  4. ORIGINAL ARTICLE High-coverage proteome analysis reveals the first insight

    E-Print Network [OSTI]

    Tian, Weidong

    Nie1 , Xiao Chang1 , Bao-Yu Hu3 , Quan-Hu Sheng1 , Lian-Shui Wang1 , Zhi-Bin Ning1 , Yi-Xue Li1 , Xiao-Kui Guo3 , Guo-Ping Zhao4 , Rong Zeng1 1 Key Laboratory of Systems Biology, Institute of Biochemistry Tech Park, Shanghai 201203, China Correspondence: Rong Zenga , Guo-Ping Zhaob a E-mail: zr@sibs.ac.cn b

  5. New insights into the $D^{*}_{s0}(2317)$ and other charm scalar mesons

    E-Print Network [OSTI]

    Guo, Zhi-Hui; Yao, De-Liang

    2015-01-01

    Through the scattering of light-pseudoscalar mesons ($\\pi,K,\\eta,\\eta'$) off charmed mesons ($D, D_s$), we study the $D^{*}_{s0}(2317)$ state and other relevant charm scalar mesons in a unitarized chiral effective field theory approach. We investigate the charm scalar meson poles with different strangeness ($S$) and isospin ($I$) quantum numbers as well as their corresponding residues, which provide the coupling strengths of the charm scalar mesons. Both the light-quark mass and $N_C$ dependences of the pole positions of the $D^{*}_{s0}(2317)$ and the poles with $(S,I)=(0,1/2)$ are analyzed in detail in this work. Interestingly we observe quite similar pion mass trajectories for the resonance pole at around 2.1 GeV with $(S,I)=(0,1/2)$ to those of the $f_0(500)$ given in the literature. When increasing the values of $N_C$ we find that a bound state and a virtual state in the $(S,I)=(1,0)$ channel asymmetrically approach the $D K$ threshold for $N_C6$, the bound and virtual states move into the complex plane o...

  6. Melanocotins of the Central Nervous System: Structural Insights on Pigmentation and Appetite

    E-Print Network [OSTI]

    Madonna, Michael Edward

    2012-01-01

    gene polymorphism and anorexia nervosa, Mol Psychiatry 6,individuals to anorexia nervosa (5, 6). Because of its

  7. Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Keravec, Marlène; Mounier, Jérôme; Prestat, Emmanuel; Vallet, Sophie; Jansson, Janet K.; Burgaud, Gaëtan; Rosec, Sylvain; Gouriou, Stéphanie; Rault, Gilles; Coton, Emmanuel; et al

    2015-08-09

    Pseudomonas aeruginosa plays a major role in cystic fibrosis (CF) progression. Therefore, it is important to understand the initial steps of P. aeruginosa infection. The structure and dynamics of CF respiratory tract microbial communities during the early stages of P. aeruginosa colonization were characterized by pyrosequencing and cloning-sequencing. The respiratory microbiota showed high diversity, related to the young age of the CF cohort (mean age 10 years). Wide inter- and intra-individual variations were revealed. A common core microbiota of 5 phyla and 13 predominant genera was found, the majority of which were obligate anaerobes. A few genera were significantly moremore »prevalent in patients never infected by P. aeruginosa. Persistence of an anaerobic core microbiota regardless of P. aeruginosa status suggests a major role of certain anaerobes in the pathophysiology of lung infections in CF. Some genera may be potential biomarkers of pulmonary infection state.« less

  8. Excited state dynamics of liquid water: Insight from the dissociation reaction following two-photon excitation

    E-Print Network [OSTI]

    Elles, Christopher G.; Shkrob, Ilya A.; Crowell, Robert A.; Bradforth, Stephen E.

    2007-04-25

    of liquid water.30,31 The energy for verti- cal ionization of the liquid is about 11 eV, and the discrep- ancy implies that nuclear motion must play a role in the ionization mechanism at low energies.26 The precise relation- ship of dissociation... and probe pulses come from fre- quency conversion of the 800 nm light from an amplified Ti:sapphire laser consisting of an oscillator #1;Spectra Physics, Tsunami#2; and two consecutive multipass amplifiers. The la- ser system produces 1.6 mJ pulses with a 1...

  9. Coral calcification : insights from inorganic experiments and coral responses to environmental variables

    E-Print Network [OSTI]

    Holcomb, Michael (Michael C.)

    2010-01-01

    The mechanisms involved in the formation of coral skeletons are examined using a laboratory model for coral calcification and the growth of living corals under different environmental conditions. Abiogenic aragonite was ...

  10. Comparative genomic analysis of nine Sphingobium strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: Sphingobium spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the lin pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the lin pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced Sphingobium spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (S. indicum B90A, S. japonicum UT26S and Sphingobium sp. SYK6). Results: Efficient HCH degraders phylogeneticallymore »clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of lin genes, DS20 was entirely devoid of lin genes (except linKLMN) whereas, LL03, P25 and RL3 were identified as lin deficient strains, as they housed incomplete lin pathways. Further, in HDIPO4, linA was found as a hybrid of two natural variants i.e., linA1 and linA2 known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the lin system and their effects on degradation efficacy. Further, the diversity in the lin gene sequences and copy number, their arrangement with respect to IS6100 and evidence for potential plasmid content elucidate possible evolutionary acquisition mechanisms for this pathway. This study further opens the horizon for selection of bacterial strains for inclusion in an HCH bioremediation consortium and suggests that HDIPO4, IP26 and B90A would be appropriate candidates for inclusion.« less

  11. Theory of Current Transients in Planar Semiconductor Devices: Insights and Applications to Organic Solar Cells

    E-Print Network [OSTI]

    Hawks, SA; Finck, BY; Schwartz, BJ

    2015-01-01

    impurity level for organic solar cells: Enhanced first-orderbulk heterojunction solar cells, Adv. Funct. Mater. 21,shunt leakage in thin-film solar cells, J. Appl. Phys. 108,

  12. Role of activity in neuromuscular synaptic degeneration: insights from Wlds mice 

    E-Print Network [OSTI]

    Brown, Rosalind

    2012-06-22

    The nervous system is a dynamic structure. Both during development and in the adult, synapses display activity-dependent plasticity which can modify their structure and function. In the neonate, activity influences the ...

  13. Insights into Conventional and Low Temperature Diesel Combustion Using Combustion Trajectory Prediction Model 

    E-Print Network [OSTI]

    Bittle, Joshua A

    2014-04-18

    Attempting to bridge the gap between typical off-line engine simulations and online real-time control strategies a computationally efficient model has been created that predicts the combustion trajectory (path through the ?-T plane). To give...

  14. CO oxidation on gold-supported iron oxides: New insights into...

    Office of Scientific and Technical Information (OSTI)

    is stable under the reaction conditions. Under an environment of COO2, they undergo oxidation (FeO) or reduction (Fe2O3) to yield nanoparticles of Fe3O4 that are not formed...

  15. Thermodynamic insight into spontaneous hydration and rapid water permeation in aquaporins

    SciTech Connect (OSTI)

    Barati Farimani, A.; Aluru, N. R. [Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Tajkhorshid, Emad [Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Department of Biochemistry and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States)

    2014-08-25

    We report here a detailed thermodynamic description of water molecules inside a biological water channel. Taking advantage of high-resolution molecular dynamics trajectories calculated for an aquaporin (AQP) channel, we compute the spatial translational and rotational components of water diffusion and entropy in AQP. Our results reveal that the spontaneous filling and entry of water into the pore in AQPs are driven by an entropic gain. Specifically, water molecules exhibit an elevated degree of rotational motion inside the pore, while their translational motion is slow compared with bulk. The partial charges of the lining asparagine residues at the conserved signature Asn-Pro-Ala motifs play a key role in enhancing rotational diffusion and facilitating dipole flipping of water inside the pore. The frequencies of the translational and rotational motions in the power spectra overlap indicating a strong coupling of these motions in AQPs. A shooting mechanism with diffusive behavior is observed in the extracellular region which might be a key factor in the fast conduction of water in AQPs.

  16. Nature of turbulent transport across sheared zonal flows: insights from gyro-kinetic simulations

    SciTech Connect (OSTI)

    Sanchez, Raul [ORNL; Newman, David E [University of Alaska; Leboeuf, Jean-Noel [JNL Scientific, Inc., Casa Grande, AZ; Decyk, Viktor [University of California, Los Angeles

    2011-01-01

    The traditional view regarding the reduction of turbulence-induced transport across a stable sheared flow invokes a reduction of the characteristic length scale in the direction perpendicular to the flow as a result of the shearing and stretching of eddies caused by the differential pull exerted in the direction of the flow. A reduced effective transport coefficient then suffices to capture the reduction, that can then be readily incorporated into a transport model. However, recent evidence from gyrokinetic simulations of the toroidal ion-temperature-gradient mode suggests that the dynamics of turbulent transport across sheared flows changes in a more fundamental manner, and that the use of reduced effective transport coefficients fails to capture the full dynamics that may exhibit both subdiffusion and non-Gaussian statistics. In this contribution, after briefly reviewing these results, we propose some candidates for the physical mechanisms responsible for endowing transport with such non-diffusive characteristics, backing these proposals with new numerical gyrokinetic data

  17. Resource Letter NSM-1: New insights into the nuclear shell model

    SciTech Connect (OSTI)

    Dean, David Jarvis [ORNL; Hamilton, J. H. [Vanderbilt University

    2011-01-01

    This Resource Letter provides a guide to the literature on the spherical shell model as applied to nuclei. The nuclear shell model describes the structure of nuclei starting with a nuclear core developed by the classical neutron and proton magic numbers N,Z=2,8,20,28,50,82, 126, where gaps occur in the single-particle energies as a shell is filled, and the interactions of valence nucleons that reside beyond that core. Various modern extensions of this model for spherical nuclei are likewise described. Significant extensions of the nuclear shell model include new magic numbers for spherical nuclei and now for deformed nuclei as well. When both protons and neutrons have shell gaps at the same spherical or deformed shapes, they can reinforce each other to give added stability to that shape and lead to new magic numbers. The vanishings of the classical spherical shell model energy gaps and magic numbers in new neutron-rich nuclei are described. Spherical and deformed shell gaps are seen to be critical for the existence of elements with Z > 100.

  18. Russia’s R&D for Low Energy Buildings: Insights for Cooperation with Russia

    SciTech Connect (OSTI)

    Schaaf, Rebecca E.; Evans, Meredydd

    2010-05-01

    Russian buildings, Russian buildings sector energy consumption. Russian government has made R&D investment a priority again. The government and private sector both invest in a range of building energy technologies. In particular, heating, ventilation and air conditioning, district heating, building envelope, and lighting have active technology research projects and programs in Russia.

  19. New insights into Arctic paleogeography and tectonics from U-Pb detrital zircon geochronology

    E-Print Network [OSTI]

    Amato, Jeff

    originated closer to the Taimyr and Verkhoyansk, east of the Polar Urals of Russia, and not from the Canadian-mass spectrometry (ICP-MS). The northern Verkhoyansk (NE Russia) has Permo- Carboniferous (265­320 Ma) and Cambro the southern Siberian craton. Chukotka, Wrangel Island (Russia), and the Lisburne Hills (western Alaska) also

  20. Redeveloping Lawrence, Massachusetts' [sic] Historic Mill District : insights into adaptive reuse in untested residential markets

    E-Print Network [OSTI]

    Clark, Heather, 1978-

    2004-01-01

    Lawrence, Massachusetts is one of a number of post-industrial cities in the northeastern United States that has the potential to convert underutilized industrial buildings into a valuable community asset, namely housing. ...

  1. Public Versus Private: Does It Matter for Water Conservation? Insights from California

    E-Print Network [OSTI]

    Kallis, Giorgos; Ray, Isha; Fulton, Julian; McMahon, James E.

    2010-01-01

    Do residential water demand side management policies measurethe ef?- cacy of demand-side management policies in times of1994). As with the demand-side management literature cited

  2. Electronic Supplementary Information (17 pages) Supramolecular photocatalysis: insights into cucurbit[8]uril

    E-Print Network [OSTI]

    Jayaraman, Sivaguru

    ) of CB8 was prepared in a 1000 mL volumetric flask. Stock solution (1 x 10-3 M) of 1 was prepared in a separate 500 mL volumetric flask. Solutions for MS and LC-MS studies were prepared by using 100 µM 1@CB8 by infusing the aqueous solution samples into the source with a syringe pump (KdScientific, model 781100, USA

  3. Movement, impacts and management of plant distributions in response to climate change: insights from invasions

    E-Print Network [OSTI]

    Alvarez, Nadir

    1265 Movement, impacts and management of plant distributions in response to climate change and management of species responses to climate change. Synthesis A major challenge in this era of rapid climate climate change. Global climate change will likely result in species extinctions, disruption of ecosystem

  4. New insights into microbial responses to oil spills from the Deepwater Horizon incident

    E-Print Network [OSTI]

    Mason, O.U.

    2012-01-01

    that exhibited propane and ethane anomalies (Valentine etpreferential loss of both ethane and propane relative toa regression of propane and ethane anomalies against oxygen

  5. The persistence of oceans on Earth-like planets: insights from the deep-water cycle

    E-Print Network [OSTI]

    Schaefer, Laura

    2015-01-01

    In this paper we present a series of models for the deep water cycle on super-Earths experiencing plate tectonics. The deep water cycle can be modeled through parameterized convection models coupled with a volatile recycling model. The convection of the silicate mantle is linked to the volatile cycle through the water-dependent viscosity. Important differences in surface water content are found for different parameterizations of convection. Surface oceans are smaller and more persistent for single layer convection, rather than convection by boundary layer instability. Smaller planets have initially larger oceans but also return that water to the mantle more rapidly than larger planets. Super-Earths may therefore be less habitable in their early years than smaller planets, but their habitability (assuming stable surface conditions), will persist much longer.

  6. New insights of asteroid 4179 Toutatis using China Chang'e-2 close flyby optical measurements

    SciTech Connect (OSTI)

    Bu, Yanlong; Tang, Geshi; Cao, Jianfeng; Hu, Songjie; Yang, Cheng; Liu, Chuankai; Di, KaiChang; Xu, Bin; Liu, Bin; Fa, Wenzhe; Hu, Tianjiang; Ding, Chibiao E-mail: tanggeshi@bacc.org.cn

    2015-01-01

    The mysteries of near-Earth asteroid 4179 Toutatis have been more comprehensively unveiled by analyzing the optical images taken during the Chang'e-2 flyby in 2012. Compared with previous works, this paper concentrates on the photogrammetric relation between the Chang'e-2 spacecraft and Toutatis and the imaging shadow effect during the flyby. Accurate models of imaging and optical measurements are developed to study Toutatis's dimensions and rotational state at the time of imaging. As the illumination study shows, the shadowed region perpendicular to the long axis accounts for 27.78% of the Toutatis images, while the long axis of the body is fully captured. With a compensation on the shadow effect, the optical measurements reveal that Toutatis's long axis is 4354 ± 56 m, the maximum length is 4391 ± 56 m, and the spatial orientation described with the angles of direction cosine during the flyby is (126.°13 ± 0.°29, 122.°98 ± 0.°21, 126.°63 ± 0.°46). Furthermore, a new triaxial ellipsoid of 4354 × 1835 × 2216 m and a volume of 7.5158 km{sup 3} are proposed based on the previous Toutatis shape model. The effectiveness of the proposed method is validated, since typical features such as the neck and endpoints agree well with the results simultaneously observed by the ground radar. Moreover, it also potentially provides a feasible approach to precisely calculate the spin period of Toutatis.

  7. Managing California’s Water: Insights from Interviews with Water Policy Experts

    E-Print Network [OSTI]

    Null, Sarah E.; Bartolomeo, Eleanor; Lund, Jay R.; Hanak, Ellen

    2012-01-01

    Sporadic funding sources Flood risk Water transfer problemsFunding Sources O (E) Flood Risk O (E) Water TransferClimate Change and Flood Risk “The technologies of the 1940s

  8. Neutron activation analysis of modern pottery: Insights for archaeological provenance research

    SciTech Connect (OSTI)

    Neff, H. [Univ. of Missouri, Columbia, MO (United States); Arnold, D.E. [Wheaton College, IL (United States); Benco, N.L. [George Washington Univ., Washington, DC (United States); Thieme, M.S. [Vanderbilt Univ., Nashville, TN (United States)

    1996-12-31

    Neutron activation analysis has been employed to characterize ceramics and raw material samples from modern pottery-making communities. The original study focused on several villages in the central highlands of Guatemala. More recently, NAA data have been collected from communities in the Valley of Oaxaca, Mexico, the northern Yucatan Peninsula, and northern Morocco. The results from all four studies can now be combined to yield a comparative perspective on paste preparation effects in archaeological provenance research.

  9. Insights Into the Effect of Trigonelline in the P53 Pathway 

    E-Print Network [OSTI]

    Justice, Jessica

    2013-09-26

    and accounts for ~1% dry matter in roasted coffee beans. Data from our laboratory has shown the ability of Trig to induce an estrogenic response through the activation of nuclear reporter assays. We investigated the effect of Trig by analyzing the apoptotic...

  10. New insights on the formation and assembly of M83 from deep near-infrared imaging

    SciTech Connect (OSTI)

    Barnes, Kate L.; Van Zee, Liese [Department of Astronomy, Indiana University, Bloomington, IN 47405 (United States); Dale, Daniel A.; Staudaher, Shawn [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Bullock, James S. [Center for Cosmology, Department of Physics and Astronomy, University of California, Irvine, CA 92697 (United States); Calzetti, Daniela [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States); Chandar, Rupali [Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606 (United States); Dalcanton, Julianne J., E-mail: barneskl@astro.indiana.edu [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States)

    2014-07-10

    We present results from new near-infrared (NIR) imaging from the Spitzer Space Telescope that trace the low surface brightness features of the outer disk and stellar stream in the nearby spiral galaxy, M83. Previous observations have shown that M83 hosts a faint stellar stream to the northwest and a star-forming disk that extends to ?3 times the optical radius (R{sub 25}). By combining the NIR imaging with archival far-ultraviolet (FUV) and H I imaging, we study the star formation history of the system. The NIR surface brightness profile has a break at ?5.'8 (equivalent to 8.1 kpc and 0.9 R{sub 25}) with a shallower slope beyond this radius, which may result from the recent accretion of gas onto the outer disk and subsequent star formation. Additionally, the ratio of FUV to NIR flux increases with increasing radius in several arms throughout the extended star forming disk, indicating an increase in the ratio of the present to past star formation rate with increasing radius. This sort of inside-out disk formation is consistent with observations of gas infall onto the outer disk of M83. Finally, the flux, size, and shape of the stellar stream are measured and the origin of the stream is explored. The stream has a total NIR flux of 11.6 mJy, which implies a stellar mass of 1 × 10{sup 8} M{sub ?} in an area subtending ?80°. No FUV emission is detected in the stream at a level greater than the noise, confirming an intermediate-age or old stellar population in the stream.

  11. Insight into Ligand Diversity and Novel Biological Roles for Family 32 Carbohydrate-Binding Modules

    E-Print Network [OSTI]

    Eirin Lopez, Jose Maria

    a new platform for the prediction of CBM binding specificity and highlight significant new targets et al. 2007). For example, Yersinia enterocolitica contains a family 32 car- bohydrate-binding module

  12. Insights On The Thermal History Of The Valles Caldera, New Mexico...

    Open Energy Info (EERE)

    ages of about 450-600 Ma. Thus, zircons from Permian strata probably originated from Precambrian rocks. Contrary to the normal relationship between FT ages and temperatures of...

  13. Structural insights into the enzymes of the serine and biotin biosynthetic pathways in mycobacterium tuberculosis 

    E-Print Network [OSTI]

    Dey, Sanghamitra

    2009-05-15

    biosynthetic pathways for Mtb survival. In this study, enzymes from these pathways were characterized using X-ray crystallographic and biochemical studies. D-3-phosphoglycerate dehydrogenase (PGDH) catalyzes the first step of phosphorylated serine biosynthesis...

  14. High pressure and temperature equations of state: A tool for insight into deep Earth systems

    E-Print Network [OSTI]

    Armentrout, Matthew Martin

    2012-01-01

    the deep Earth, interpretation of seismic observables, andof state allows interpretation of the seismic observations,

  15. New insights into the quasi-periodic X-ray burster GS 0836-429

    E-Print Network [OSTI]

    Aranzana, E; Kuulkers, E

    2015-01-01

    GS 0836-429 is a neutron star X-ray transient that displays Type-I X-ray bursts. In 2003 and 2004 it experienced two outbursts in X-rays. We present here an analysis of the system bursting properties during these outbursts. We studied the evolution of the 2003-2004 outbursts in soft X-rays using RXTE (2.5-12 keV; ASM), and in hard X-rays with INTEGRAL (17-80 keV, IBIS/ISGRI). Using data from the JEM-X monitor onboard INTEGRAL we detected 61 Type-I X-ray bursts, and confirm that the source displayed a quasi-periodic burst recurrence time of about 2.3 hours. We improve the characterization of the fuel composition, as well as the description of the typical burst durations and fluences. We estimate the average value of $\\alpha$ to be $49\\pm\\,3$. This value together with the observed burst profiles indicate a regime of a mixed He/H runaway triggered by unstable helium ignition. In addition, we report the detection of four series of double bursts, with burst recurrence times of $\\leq\\,20$ minutes. The measured recu...

  16. Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation

    E-Print Network [OSTI]

    Morar, Mariya

    In the fourth step of the purine biosynthetic pathway, formyl glycinamide ribonucleotide (FGAR) amidotransferase, also known as PurL, catalyzes the conversion of FGAR, ATP, and glutamine to formyl glycinamidine ribonucleotide ...

  17. Late-Onset Group B Streptococcal Infection in Identical Twins: Insight to Disease Pathogenesis

    E-Print Network [OSTI]

    Nizet, Victor

    by helicopter to our tertiary care center. Vital signs were: weight 3.7 kg, heart rate 212 beats/min, blood

  18. Melanocotins of the Central Nervous System: Structural Insights on Pigmentation and Appetite

    E-Print Network [OSTI]

    Madonna, Michael Edward

    2012-01-01

    processing in the hypothalamus: impact on melanocortinprocessing in the hypothalamus: impact on melanocortinpeptide release in the hypothalamus, Brain research 1032,

  19. Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions

    E-Print Network [OSTI]

    Calisi, Rebecca Marie

    2010-01-01

    expression in the rat hypothalamus. Soc. Neurosci. Annualwithin the basal tuberal hypothalamus and median eminence of2004). Located in the hypothalamus, GnIH-producing neurons

  20. Transmembrane Signaling of Chemotaxis Receptor Tar: Insights from Molecular Dynamics Simulation Studies

    E-Print Network [OSTI]

    Park, Hahnbeom; Im, Wonpil; Seok, Chaok

    2011-06-22

    Transmembrane signaling of chemotaxis receptors has long been studied, but how the conformational change induced by ligand binding is transmitted across the bilayer membrane is still elusive at the molecular level. To ...