National Library of Energy BETA

Sample records for induced adaptive response

  1. The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

    SciTech Connect (OSTI)

    Miyata, Ryohei; Eeden, Stephan F. van

    2011-12-15

    Emerging epidemiological evidence suggests that exposure to particulate matter (PM) air pollution increases the risk of cardiovascular events but the exact mechanism by which PM has adverse effects is still unclear. Alveolar macrophages (AM) play a major role in clearing and processing inhaled PM. This comprehensive review of research findings on immunological interactions between AM and PM provides potential pathophysiological pathways that interconnect PM exposure with adverse cardiovascular effects. Coarse particles (10 {mu}m or less, PM{sub 10}) induce innate immune responses via endotoxin-toll-like receptor (TLR) 4 pathway while fine (2.5 {mu}m or less, PM{sub 2.5}) and ultrafine particles (0.1 {mu}m or less, UFP) induce via reactive oxygen species generation by transition metals and/or polyaromatic hydrocarbons. The innate immune responses are characterized by activation of transcription factors [nuclear factor (NF)-{kappa}B and activator protein-1] and the downstream proinflammatory cytokine [interleukin (IL)-1{beta}, IL-6, and tumor necrosis factor-{alpha}] production. In addition to the conventional opsonin-dependent phagocytosis by AM, PM can also be endocytosed by an opsonin-independent pathway via scavenger receptors. Activation of scavenger receptors negatively regulates the TLR4-NF-{kappa}B pathway. Internalized particles are subsequently subjected to adaptive immunity involving major histocompatibility complex class II (MHC II) expression, recruitment of costimulatory molecules, and the modulation of the T helper (Th) responses. AM show atypical antigen presenting cell maturation in which phagocytic activity decreases while both MHC II and costimulatory molecules remain unaltered. PM drives AM towards a Th1 profile but secondary responses in a Th1- or Th-2 up-regulated milieu drive the response in favor of a Th2 profile.

  2. Poster Session 08: Bystander and other Low Dose Effect Exogenous carbon monoxide suppresses adaptive response induced

    E-Print Network [OSTI]

    Yu, Peter K.N.

    Poster Session 08: Bystander and other Low Dose Effect Exogenous carbon monoxide suppresses; adaptive response; zebrafish embryos Journal of Radiation Research, 2014, 55, i115 Supplement doi: 10 prepared medium with the chemical at different time points after the application of the priming dose. Our

  3. Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB

    SciTech Connect (OSTI)

    Hamill, Michael J.; Jost, Marco; Wong, Cintyu; Elliott, Sean J.; Drennan, Catherine L. (MIT); (BU)

    2011-11-21

    The process known as 'adaptive response' allows Escherichia coli to respond to small doses of DNA-methylating agents by upregulating the expression of four proteins. While the role of three of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear. Although AidB is a flavoprotein, no catalytic role has been established for the bound cofactor. Here we investigate the possibility that flavin plays a structural role in the assembly of the AidB tetramer. We report the generation and biophysical characterization of deflavinated AidB and of an AidB mutant that has greatly reduced affinity for flavin adenine dinucleotide (FAD). Using fluorescence quenching and analytical ultracentrifugation, we find that apo AidB has a high affinity for FAD, as indicated by an apparent dissociation constant of 402.1 {+-} 35.1 nM, and that binding of substoichiometric amounts of FAD triggers a transition in the AidB oligomeric state. In particular, deflavinated AidB is dimeric, whereas the addition of FAD yields a tetramer. We further investigate the dimerization and tetramerization interfaces of AidB by determining a 2.8 {angstrom} resolution crystal structure in space group P3{sub 2} that contains three intact tetramers in the asymmetric unit. Taken together, our findings provide strong evidence that FAD plays a structural role in the formation of tetrameric AidB.

  4. Radiation-induced bystander effect and adaptive response in mammalian cells

    E-Print Network [OSTI]

    responses at low doses of radiation and have the potential to impact the shape of the dose at low doses of radiation and have the potential to impact the shape of the dose­response relationship, Columbia University, New York, NY 10032, USA b Radiation Effect Research Foundation, Hiroshima, Japan

  5. Poster Session 08: Bystander and other Low Dose Effect Roles of nitric oxide in adaptive response induced in zebrafish

    E-Print Network [OSTI]

    Yu, Peter K.N.

    Poster Session 08: Bystander and other Low Dose Effect Roles of nitric oxide in adaptive response Radiat Res 2013;54:736­47. Journal of Radiation Research, 2014, 55, i114 Supplement doi: 10.1093/jrr/rrt161 © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research

  6. Adaptive Demand Response: Online Learning of Restless and Controlled Bandits

    E-Print Network [OSTI]

    Liu, Mingyan

    Adaptive Demand Response: Online Learning of Restless and Controlled Bandits Qingsi Wang, Mingyan realized curtailment, not the curtailment of each load. We develop an adaptive demand response learning like UCB1. I. INTRODUCTION Electric loads participating in demand response programs provide a variety

  7. Adapting Induced Pluripotent Stem Cells For Clinical Use

    E-Print Network [OSTI]

    Brutlag, Doug

    ://www.nature.com/nbt/journal/v27/n5/full/nbt.1535.html · Kim, D. et al. Generation of human induced pluripotent stem cellsAdapting Induced Pluripotent Stem Cells For Clinical Use Dana Wyman Professor Brutlag Genomics Pluripotent Stem Cells 7 days hES medium +MEF #12;Immunofluorescence Test ES Cells (+ control) Untransduced

  8. Beyond Adapting to Climate Change: Embedding Adaptation in Responses to Multiple Threats and Stresses

    SciTech Connect (OSTI)

    Wilbanks, Thomas J; Kates, Dr. Robert W.

    2010-01-01

    Climate change impacts are already being experienced in every region of the United States and every part of the world most severely in Arctic regions and adaptation is needed now. Although climate change adaptation research is still in its infancy, significant adaptation planning in the United States has already begun in a number of localities. This article seeks to broaden the adaptation effort by integrating it with broader frameworks of hazards research, sustainability science, and community and regional resilience. To extend the range of experience, we draw from ongoing case studies in the Southeastern United States and the environmental history of New Orleans to consider the multiple threats and stresses that all communities and regions experience. Embedding climate adaptation in responses to multiple threats and stresses helps us to understand climate change impacts, themselves often products of multiple stresses, to achieve community acceptance of needed adaptations as co-benefits of addressing multiple threats, and to mainstream the process of climate adaptation through the larger envelope of social relationships, communication channels, and broad-based awareness of needs for risk management that accompany community resilience.

  9. The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo

    E-Print Network [OSTI]

    Frick, Lauren Elizabeth

    2007-01-01

    The Escherichia coli AlkB protein is an exceptionally versatile DNA repair enzyme. Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglu ...

  10. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  11. Radioadaptive Response Induced by Alpha-Particle-Induced Stress

    E-Print Network [OSTI]

    Yu, Peter K.N.

    of radioadaptive response (RAR) by com- munication of radiation-induced bystander signals. RAR is a kind of low-dose in the unirradiated embryos. Introduction Recent research have demonstrated the communication of radiation radiation effect, which occurs when a small preceding priming dose decreases the biological effectiveness

  12. Block-structured Adaptive Finite Volume Methods for Shock-Induced Combustion

    E-Print Network [OSTI]

    Deiterding, Ralf

    Block-structured Adaptive Finite Volume Methods for Shock-Induced Combustion Simulation Ralf-Induced Combustion Simulation 1 #12;Structure of the lectures Block-structured Adaptive Finite Volume Methods for Shock-Induced Combustion Simulation 2 #12;Structure of the lectures 1. Fundamentals of finite volume

  13. Gene induction and adaptive responses in irradiated cells: Mechanisms and clinical implications

    SciTech Connect (OSTI)

    Lehnert, S. [McGill Univ., Quebec (Canada)

    1995-01-01

    A characteristic of living things, conserved throughout evolution, is their capacity to react to environmental insult. From bacteria to yeast to human cells, environmental inputs induce changes in the program of genes expressed. A subset of this response, of particular interest to the radiobiologists and radiation oncologists who gathered for this meeting, is the case of radiation-mediated gene induction. A large number of genes have been reported to be up/down-regulated by ionizing radiation; some of these have been identified, while others have so far preserved their anonymity as bands and blots on gels and membranes. It is safe to say that many more such genes will be discovered in the future as the scientific and clinical significance of these processes is better understood. Substantial evidence, extending back many years, suggests the existence of an adaptive response, apparent as cellular radioprotective mechanisms which can be up-regulated after a small dose of radiation. At the molecular level, the timing of the changes in expression of induced genes and of the changes in levels of nuclear and cytoplasmic proteins which they encode is such as to support involvement of these elements in induced radioresistance. The adaptive response is one component of the battery of intrinsic factors which influence the response of tumors to radiation. Radiation-induced gene products encompass a spectrum of activities including cell cycle control, DNA repair, signal transduction, apoptosis and oncogenesis, all of which can influence tumor radioresponse and contribute to the multifactorial radioresistant phenotype. Growth factors and cytokines are encoded by several early and late-responding genes whose expression is up-regulated by radiation. These must be assumed to affect the toxicity of radiation toward early- and late-responding normal tissues profoundly by promoting repair or conversely by acting synergistically to enhance radiation damage.

  14. Distributed Demand Response and User Adaptation in Smart Grids

    E-Print Network [OSTI]

    Fan, Zhong

    2010-01-01

    This paper proposes a distributed framework for demand response and user adaptation in smart grid networks. In particular, we borrow the concept of congestion pricing in Internet traffic control and show that pricing information is very useful to regulate user demand and hence balance network load. User preference is modeled as a willingness to pay parameter which can be seen as an indicator of differential quality of service. Both analysis and simulation results are presented to demonstrate the dynamics and convergence behavior of the algorithm.

  15. Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death*S

    E-Print Network [OSTI]

    Morimoto, Richard

    Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death chaperones, inducible by heat shock and a variety of other stresses, have critical roles in protein homeostasis, balancing cell stress with adaptation, survival, and cell death mechanisms. In transformed cells

  16. Seismic response of fractures and induced anisotropy in poroelastic media

    E-Print Network [OSTI]

    Santos, Juan

    Seismic response of fractures and induced anisotropy in poroelastic media Juan E. Santos Instituto) and R. Mart´inez Corredor (UNLP) Department of Mathematics, University of Calgary, October 2014 Seismic and angular variations of velocity and attenuation of seismic waves. Seismic response of fractures and induced

  17. Seismic response of fractures and induced anisotropy in poroelastic media

    E-Print Network [OSTI]

    Santos, Juan

    Seismic response of fractures and induced anisotropy in poroelastic media Juan E. Santos stituto) and R. Mart´inez Corredor (UNLP) Department of Mathematics, University of Calgary, October 2014 Seismic variations of velocity and attenuation of seismic waves. Seismic response of fractures and induced anisotropy

  18. Adaptive Evolution of a Stress Response Protein Tom J. Little1

    E-Print Network [OSTI]

    Obbard, Darren

    Stress responses classically involve heat shock proteins or molecular chaperones that maintain proteinAdaptive Evolution of a Stress Response Protein Tom J. Little1 *, Lenny Nelson2 , Ted Hupp2 1 of the mammalian stress response gene SEP53, a member of the epidermal differentiation complex fused-gene family

  19. Between adaptation and resistance : labor responses to globalization in France

    E-Print Network [OSTI]

    Ancelovici, Marcos, 1971-

    2008-01-01

    This dissertation aims at accounting for labor responses to globalization in France. It addresses this issue through a comparative study of two labor organizations-the French Democratic Labor Confederation (CFDT) and the ...

  20. A parallel adaptive method for simulating shock-induced combustion with detailed

    E-Print Network [OSTI]

    Deiterding, Ralf

    A parallel adaptive method for simulating shock-induced combustion with detailed chemical kinetics combustion phenomena in gases, particularly detonation waves. The method uses a Cartesian mesh, that are characteristic for accident scenarios. Innovative technical applications of gaseous detonations include pulsed

  1. Systematic identification of genes and transduction pathways involved in radio-adaptive response

    SciTech Connect (OSTI)

    Wu, Honglu

    2015-05-22

    Low doses of radiation have been shown to protect against the biological effects of later exposure to toxic levels of radiation. In this study, we propose to identify the molecular mechanisms of this adaptive response by systematically identifying the genes that play a role in radio-protection. In the original proposal, a human cell line that is well-documented to exhibit the radio-adaptive effect was to be used. In this revised study plan, we will use a mouse model, C57BL/6, which has also been well investigated for radio-adaptation. The goal of the proposed study is to enhance our understanding of cellular responses to low doses of radiation exposure at the molecular level.

  2. Host Cell Responses Induced by Hepatitis C Virus Binding

    E-Print Network [OSTI]

    Timmer, Jens

    Host Cell Responses Induced by Hepatitis C Virus Binding Xinhua Fang,1 Mirjam B. Zeisel,1 Jochen. Blum,1 and Thomas F. Baumert1,5 Initiation of hepatitis C virus (HCV) infection is mediated by docking nitiation of hepatitis C virus (HCV) infection is me- diated by docking of the viral envelope to the hepa

  3. the Adaptive Response, Genetic Haplo-Insufficiency and Genomic Instability

    SciTech Connect (OSTI)

    Geard, Charles R.

    2014-12-12

    The linear no-threshold (LNT) hypothesis is the driving force in the establishment of radiation protection standards. However, the scientific basis for linearity has been brought into question, particularly due to the concerns about induced radiation resistance as it pertains to oxidative stress. Specifically, we investigated the observation that tumor hypoxia is associated with malignant progression, increased metastases, chemo- and radioresistance and poor prognosis. Experiments were conducted with non-malignant 3T3/NIH cells and normal human lung fibroblasts (NHLF) that were subjected to ?-irradiation under the levels of oxygen resembling those in growing tumors, and related our data to the concentrations of dissolved oxygen (DO), which is a better indicator of the amounts of residual oxygen inside the cells cultured in the hypoxic or anoxic atmosphere. We found that at DO levels about 0.5 mg/L cells subjected to both short-term (17 hours) and prolonged (48-72 hours) hypoxia continued to proliferate, and that apoptotic events were decreased at the early hours of hypoxic treatment. We showed that the short-term hypoxia up-regulated p53-binding protein 1 (53BP1) and resulted in facilitated 53BP1 nuclear foci formation and disappearance, thus indicating the higher efficiency of DNA double strand breaks repair processes. The latter was confirmed by the lower micronuclei incidence in irradiated hypoxic cells.

  4. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents

    E-Print Network [OSTI]

    Schafer, William R.

    In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents di Genetica e Biofisica--ABT, Napoli, Italy ASH sensory neurons are required in Caenorhabditis and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons

  5. Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

    E-Print Network [OSTI]

    Liliensiek, Birgit; Weigand, Markus A.; Bierhaus, Angelika; Nicklas, Werner; Kasper, Michael; Hofer, Stefan; Plachky, Jens; Grö ne, Herman-Josef; Kurschus, Florian C.; Schmidt, Ann Marie; Yan, Shirley ShiDu; Martin, Eike; Schleicher, Erwin; Stern, David M.; Hä mmerling, Gü nter J.; Nawroth, Peter P.; Arnold, Bernd

    2004-06-01

    of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE...

  6. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents

    E-Print Network [OSTI]

    Schafer, William R.

    Erratum In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical (arbitrary units) Intensity 10 mM copper 3 s 2 s 1 s 0 s -1 s 1.6 2.1 m)µ( YFP CFP Dendrite Soma ASH Time (s following panels. Scale bar, 200 mm. (B) Diagram of the animal's head with one of the two symmetrical ASH

  7. Scientists in a Changed Institutional Environment: Subjective Adaptation and Social Responsibility Norms in Russia

    SciTech Connect (OSTI)

    Gerber, T P; Ball, D Y

    2008-06-05

    How do scientists react when the institutional setting in which they conduct their work changes radically? How do long-standing norms regarding the social responsibility of scientists fare? What factors influence whether scientists embrace or reject the new institutions and norms? We examine these questions using data from a unique survey of 602 scientists in Russia, whose science system experienced a sustained crisis and sweeping changes in science institutions following the collapse of the Soviet Union. We develop measures of how respondents view financing based on grants and other institutional changes in the Russian science system, as well as measures of two norms regarding scientists social responsibility. We find that the majority of scientists have adapted, in the sense that they hold positive views of the new institutions, but a diversity of orientations remains. Social responsibility norms are common among Russian scientists, but far from universal. The main correlates of adaptation are age and current success at negotiating the new institutions, though prospective success, work context, and ethnicity have some of the hypothesized associations. As for social responsibility norms, the main source of variation is age: younger scientists are more likely to embrace individualistic rather than socially-oriented norms.

  8. Cyclic 3',5'-AMP Relay i n Dictyostelium discoideum V. Adaptation of the CAMP Signaling Response

    E-Print Network [OSTI]

    Devreotes, Peter

    Cyclic 3',5'-AMP Relay i n Dictyostelium discoideum V. Adaptation of the CAMP Signaling Response, and then immediately given test stimuli of 10-8 M to 2.5 X 10-7 M cAMP. The response to a given test stimulus to the concentration of the test stimulus . The responses to test stimuli of 10-8, 5 X 10-8, 10-7, or 2.5 X 10-7 M c

  9. Hypochlorous acid and hydrogen peroxide-induced negative regulation of Salmonella enterica serovar Typhimurium ompW by the response regulator ArcA

    E-Print Network [OSTI]

    2012-01-01

    induced negative regulation of Salmonella enterica serovarsuperoxide dismutase in Salmonella. FEMS Microbiol LettAdaptation Sensitizes Salmonella Typhimurium to Hypochlorous

  10. Crack Response to Blast Vibrations and Moisture Induced Volumetric Changes in Foundation Soils

    E-Print Network [OSTI]

    Crack Response to Blast Vibrations and Moisture Induced Volumetric Changes in Foundation Soils By C, Evanston, IL. Abstract In this paper vibratory crack response is compared to that produced by volumetric over a period of weeks to several months. On the other hand, crack response produced by volumetric

  11. Proteomic-based mechanistic investigation of low-dose radiation-induced cellular responses/effects

    SciTech Connect (OSTI)

    Chen, Xian

    2013-10-23

    The goal of our project is to apply our unique systems investigation strategy to reveal the molecular mechanisms underlying the radiation induction and transmission of oxidative damage, adaptive response, and bystander effect at low-doses. Beginning with simple in vitro systems such as fibroblast or epithelial pure culture, our amino acid-coded mass tagging (AACT) comparative proteomic platform will be used to measure quantitatively proteomic changes at high- or low-dose level with respect to their endogenous damage levels respectively, in which a broad range of unique regulated proteins sensitive to low-dose IR will be distinguished. To zoom in how these regulated proteins interact with other in the form of networks in induction/transmission pathways, these regulated proteins will be selected as baits for making a series of fibroblast cell lines that stably express each of them. Using our newly developed method of ?dual-tagging? quantitative proteomics that integrate the capabilities of natural complex expression/formation, simple epitope affinity isolation (not through tandem affinity purification or TAP), and ?in-spectra? AACT quantitative measurements using mass spectrometry (MS), we will be able to distinguish systematically interacting proteins with each bait in real time. Further, in addition to both proteome-wide (global differentially expressed proteins) and pathway-scale (bait-specific) profiling information, we will perform a computational network analysis to elucidate a global pathway/mechanisms underlying cellular responses to real-time low-dose IR. Similarly, we will extend our scheme to investigate systematically those induction/transmission pathways occurring in a fibroblast-epithelial interacting model in which the bystander cell (fibroblast) monitor the IR damage to the target cell (epithelial cell). The results will provide the proteome base (molecular mechanisms/pathways for signaling) for the low dose radiation-induced essential tissue environment interactions, including cell-cell, extracellular matrix and extracellular paracrine interactions.

  12. Sound-induced illusory ash perception: role of gamma band responses

    E-Print Network [OSTI]

    Shams, Ladan B.

    Sound-induced illusory £ash perception: role of gamma band responses Joydeep Bhattacharya,1,2,CA; accepted 9 July 2002 In the recently discovered sound-induced illusory £ash phenomen- on, a single £ash substrates distinguishing illusion and no-illusion (i.e. perception of single £ash) percepts are under

  13. Magnetic response enhancement via electrically induced magnetic moments

    E-Print Network [OSTI]

    B. Jungnitsch; J. Evers

    2008-04-22

    The realization of negative refraction in atomic gases requires a strong magnetic response of the atoms. Current proposals for such systems achieve an enhancement of the magnetic response by a suitable laser field configuration, but still rely on high gas densities. Thus further progress is desirable, and this requires an understanding of the precise mechanism for the enhancement. Therefore, here we study the magnetic and electric response to a probe field interacting with three-level atoms in ladder configuration. In our first model, the three transitions are driven by a control field and the electric and magnetic component of the probe field, giving rise to a closed interaction loop. In a reference model, the coherent driving is replaced by an incoherent pump field. A time-dependent analysis of the closed-loop system enables us to identify the different contributions to the medium response. A comparison with the reference system then allows one to identify the physical mechanism that leads to the enhancement. It is found that the enhancement occurs at so-called multiphoton resonance by a scattering of the coupling field and the electric probe field mode into the magnetic probe field mode. Based on these results, conditions for the enhancement are discussed.

  14. Sirt2 suppresses inflammatory responses in collagen-induced arthritis

    SciTech Connect (OSTI)

    Lin, Jiangtao; Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 ; Sun, Bing; Jiang, Chuanqiang; Hong, Huanyu; Zheng, Yanping

    2013-11-29

    Highlights: •Sirt2 expression decreases in collagen-induced arthritis (CIA). •Sirt2 knockout aggravates severity of arthritis in mice with CIA. •Sirt2 knockout increases levels of pro-inflammatory factors in the serum. •Sirt2 deacetylates p65 and inhibits pro-inflammatory factors expression. •Sirt2 rescue abates severity of arthritis in mice with CIA. -- Abstract: Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD{sup +}-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability, carcinogenesis, and energy metabolism. Among the sirtuin family members, Sirt1 and Sirt6 are critically involved in the development of arthritis. It remains unknown whether other sirtuin family members participate in arthritis. Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence. The protein and mRNA levels of Sirt2 significantly decreased in joint tissues of mice with CIA. When immunized with collagen, Sirt2-KO mice showed aggravated severity of arthritis based on clinical scores, hind paw thickness, and radiological and molecular findings. Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-?B) at lysine 310, resulting in reduced expression of NF-?B-dependent genes, including interleukin 1? (IL-1?), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13. Importantly, our rescue experiment showed that Sirt2 re-expression abated the severity of arthritis in Sirt2-KO mice. Those findings strongly indicate Sirt2 as a considerably inhibitor of the development of arthritis.

  15. Morphological responses and sediment processes following a typhoon-induced dam failure, Dahan

    E-Print Network [OSTI]

    Tullos, Desiree

    Morphological responses and sediment processes following a typhoon-induced dam failure, Dahan River adjustments following an abrupt and voluminous sediment pulse are investigated in the context of site and valley characteristics and time-varying sediment transport regimes. Approximately 10.5 x 106 m3 of stored

  16. Optical response of grating-coupler-induced intersubband resonances: The role of Wood's anomalies

    E-Print Network [OSTI]

    Ludwig-Maximilians-Universität, München

    Optical response of grating-coupler-induced intersubband resonances: The role of Wood's anomalies L of Wood's anomalies. S0163-1829 97 05403-9 I. INTRODUCTION The optical and electronic properties at, e.g., a modulation- doped semiconductor heterojunction have been widely stud- ied in the recent

  17. Response to ``Comment on `Ultrasound-induced lung hemorrhage is not caused by inertial cavitation'''

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Response to ``Comment on `Ultrasound-induced lung hemorrhage is not caused by inertial cavitation cavitation nuclei in lung versus other tissues such that overpressure does not affect the inertial cavitation threshold in lung, then there would be an impact on the con- clusion in our publication.2 To examine

  18. Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation

    SciTech Connect (OSTI)

    Robinson, Joshua F.; Yu, Xiaozhong; Moreira, Estefania G.; Hong, Sungwoo; Faustman, Elaine M.

    2011-01-15

    Arsenic (As) and cadmium (Cd) are well-characterized teratogens in animal models inducing embryotoxicity and neural tube defects (NTDs) when exposed during neurulation. Toxicological research is needed to resolve the specific biological processes and associated molecular pathways underlying metal-induced toxicity during this timeframe in gestational development. In this study, we investigated the dose-dependent effects of As and Cd on gene expression in C57BL/6J mouse embryos exposed in utero during neurulation (GD8) to identify significantly altered genes and corresponding biological processes associated with embryotoxicity. We quantitatively examined the toxicogenomic dose-response relationship at the gene level. Our results suggest that As and Cd induce dose-dependent gene expression alterations representing shared (cell cycle, response to UV, glutathione metabolism, RNA processing) and unique (alcohol/sugar metabolism) biological processes, which serve as robust indicators of metal-induced developmental toxicity and indicate underlying embryotoxic effects. Our observations also correlate well with previously identified impacts of As and Cd on specific genes associated with metal-induced toxicity (Cdkn1a, Mt1). In summary, we have identified in a quantitative manner As and Cd induced dose-dependent effects on gene expression in mouse embryos during a peak window of sensitivity to embryotoxicity and NTDs in the sensitive C57BL/6J strain.

  19. Global transcriptional, physiological and metabolite analyses of Desulfovibrio vulgaris Hildenborough responses to salt adaptation

    E-Print Network [OSTI]

    He, Z.

    2010-01-01

    Zhou, and J. D. Keasling. 2006. Salt stress in Desulfovibrioregulation of acid, heat, and salt tolerance in EscherichiaMR-1 in response to elevated salt conditions. J. Bacteriol.

  20. Risk Analysis and Adaptive Response Planning for Water Distribution Systems Contamination Emergency Management 

    E-Print Network [OSTI]

    Rasekh, Amin

    2012-10-19

    of terrorism, several aspects of emergency management for WDSs remain at an undeveloped stage. A set of methods is developed to analyze the risk and consequences of WDS contamination events and develop emergency response support tools. Monte Carlo...

  1. Characterization of abdominal adiposity and its relationship to adipokines and the adaptive immune response

    E-Print Network [OSTI]

    Ozias, Marlies

    2013-12-31

    risk for pregnancy- induced hypertension, preeclampsia, gestational diabetes mellitus (GDM), and cesarean delivery [3-5]. Additionally, after delivery there is a greater risk for postpartum infection, hemorrhage [5], and weight retention [6... complications such as preeclampsia or intrauterine growth restriction (IUGR) have a higher prevalence of metabolic syndrome seven years after delivery compared to women who had healthy pregnancies [11]. As pregnancy introduces dramatic change to the female...

  2. Influence of inorganic and organic nutrients on aerobic biodegradation and on the adaptation response of subsurface microbial communities

    SciTech Connect (OSTI)

    Swindoll, C.M.; Aelion, C.M.; Pfaender, F.K.

    1988-01-01

    The influence of inorganic and organic amendments on the mineralization of ethylene dibromide, rho-nitrophenol, phenol, and toluene was examined in subsurface soil samples from a pristine aquifer near Lula, Oklahoma. The responses indicate that the metabolic abilities and nutrient requirements of ground water microorganisms vary substantially within an aquifer. In some samples, additions of inorganic nutrients resulted in a more rapid adaptation to the test substrate and a higher rate of metabolism, indicating that metabolism may have been limited by these nutrients. In other samples from the same aquifer layer, inorganic amendments had little or no influence on mineralization. In general, the addition of multiple inorganic nutrients resulted in a greater enhancement of degradation than did the addition of single substances. Additions of alternate carbon sources, such as glucose or amino acids, inhibited the mineralization of the xenobiotic substrates. This inhibition appears to be the result of the preferential utilization of the more easily degradable carbon amendments.

  3. Ultrafast terahertz-induced response of GeSbTe phase-change materials

    SciTech Connect (OSTI)

    Shu, Michael J.; Zalden, Peter; Chen, Frank; Weems, Ben; Chatzakis, Ioannis; Xiong, Feng; Jeyasingh, Rakesh; Pop, Eric; Philip Wong, H.-S.; Hoffmann, Matthias C.; Wuttig, Matthias; Lindenberg, Aaron M.

    2014-06-23

    The time-resolved ultrafast electric field-driven response of crystalline and amorphous GeSbTe films has been measured all-optically, pumping with single-cycle terahertz pulses as a means of biasing phase-change materials on a sub-picosecond time-scale. Utilizing the near-band-gap transmission as a probe of the electronic and structural response below the switching threshold, we observe a field-induced heating of the carrier system and resolve the picosecond-time-scale energy relaxation processes and their dependence on the sample annealing condition in the crystalline phase. In the amorphous phase, an instantaneous electroabsorption response is observed, quadratic in the terahertz field, followed by field-driven lattice heating, with Ohmic behavior up to 200?kV/cm.

  4. Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash

    SciTech Connect (OSTI)

    Marchini, T.; Magnani, N.D.; Paz, M.L.; Vanasco, V.; Tasat, D.; González Maglio, D.H.; and others

    2014-01-15

    It is suggested that systemic oxidative stress and inflammation play a central role in the onset and progression of cardiovascular diseases associated with the exposure to particulate matter (PM). The aim of this work was to evaluate the time changes of systemic markers of oxidative stress and inflammation, after an acute exposure to Residual Oil Fly Ash (ROFA). Female Swiss mice were intranasally instilled with a ROFA suspension (1.0 mg/kg body weight) or saline solution, and plasma levels of oxidative damage markers [thiobarbituric acid reactive substances (TBARSs) and protein carbonyls], antioxidant status [reduced (GSH) and oxidized (GSSG) glutathione, ascorbic acid levels, and superoxide dismutase (SOD) activity], cytokines levels, and intravascular leukocyte activation were evaluated after 1, 3 or 5 h of exposure. Oxidative damage to lipids and decreased GSH/GSSG ratio were observed in ROFA-exposed mice as early as 1 h. Afterwards, increased protein oxidation, decreased ascorbic acid content and SOD activity were found in this group at 3 h. The onset of an adaptive response was observed at 5 h after the ROFA exposure, as indicated by decreased TBARS plasma content and increased SOD activity. The observed increase in oxidative damage to plasma macromolecules, together with systemic antioxidants depletion, may be a consequence of a systemic inflammatory response triggered by the ROFA exposure, since increased TNF-? and IL-6 plasma levels and polymorphonuclear leukocytes activation was found at every evaluated time point. These findings contribute to the understanding of the increase in cardiovascular morbidity and mortality, in association with environmental PM inhalation. - Highlights: • An acute exposure to ROFA triggers the occurrence of systemic oxidative stress. • Changes in plasmatic oxidative stress markers appear as early as 1 h after exposure. • ROFA induces proinflammatory cytokines release and intravascular leukocyte activation. • PMN activation is a relevant source of reactive oxygen species in this model. • These findings may account for previously described cardiopulmonary alterations.

  5. ADC response to radiation therapy correlates with induced changes in radiosensitivity

    SciTech Connect (OSTI)

    Larocque, Matthew P.; Syme, Alasdair; Allalunis-Turner, Joan; Fallone, B. Gino [Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Experimental Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada)

    2010-07-15

    Purpose: Magnetic resonance imaging was used to compare the responses of human glioma tumor xenografts to a single fraction of radiation, where a change in radiosensitivity was induced by use of a suture-based ligature. Methods: Ischemia was induced by use of a suture-based ligature. Six mice were treated with 800 cGy of 200 kVp x rays while the ligature was applied. An additional six mice had the ligature applied for the same length of time but were not irradiated. Quantitative maps of each tumor were produced of water apparent diffusion coefficient (ADC) and transverse relaxation time (T2). Mice were imaged before and at multiple points after treatment. Volumetric, ADC, and T2 responses of the ligated groups were compared to previously measured responses of the same tumor model to the same radiation treatment, as well as those from an untreated control group. Results: Application of the ligature without irradiation did not affect tumor ADC values, but did produce a temporary decrease in tumor T2 values. Average tumor T2 was reduced by 6.2% 24 h after the ligature was applied. Average tumor ADC increased by 9.6% 7 days after irradiation with a ligature applied. This response was significantly less than that observed in the same tumor model when no ligature is present (21.8% at 7 days after irradiation). Conclusions: These observations indicate that the response of ADC to radiation therapy is not determined entirely by physical dose deposition, but at least in part by radiosensitivity and resultant biological response.

  6. Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

    E-Print Network [OSTI]

    Li, Deyu

    The AlkB enzyme is an Fe(II)- and ?-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of ...

  7. Neurodegeneration and adaptation in response to low-dose photon irradiation

    SciTech Connect (OSTI)

    Limoli, Charles L.

    2014-10-27

    Neural stem and precursor cells (i.e. multipotent neural cells) are concentrated in the neurogenic regions of the brain (hippocampal dentate gyrus, subventricular zones), and considerable evidence suggests that these cells are important in mediating the stress response of the CNS after damage from ionizing radiation. The capability of these cells to proliferate, migrate and differentiate (i.e. to undergo neurogenesis) suggests they can participate in the repair and maintenance of CNS functions by replacing brain cells damaged or depleted due to irradiation. Importantly, we have shown that multipotent neural cells are markedly sensitive to irradiation and oxidative stress, insults that compromise neurogenesis and hasten the onset and progression of degenerative processes that are likely to have an adverse impact on cognition. Our past and current work has demonstrated that relatively low doses of radiation cause a persistent (weeks-months) oxidative stress in multipotent neural cells that can elicit a range of degenerative sequelae in the CNS. Therefore, our project is focused on determining the extent that endogenous and redox sensitive multipotent neural cells represent important radioresponsive targets for low dose radiation effects. We hypothesize that the activation of redox sensitive signaling can trigger radioadaptive changes in these cells that can be either harmful or beneficial to overall cognitive health.

  8. Hierarchical Formation of Galaxies with Dynamical Response to Supernova-Induced Gas removal

    E-Print Network [OSTI]

    Masahiro Nagashima; Yuzuru Yoshii

    2004-04-25

    We reanalyze the formation and evolution of galaxies in the hierarchical clustering scenario. Using a semi-analytic model (SAM) of galaxy formation described in this paper, which we hereafter call the Mitaka model, we extensively investigate the observed scaling relations of galaxies among photometric, kinematic, structural and chemical characteristics. In such a scenario, spheroidal galaxies are assumed to be formed by major merger and subsequent starburst, in contrast to the traditional scenario of monolithic cloud collapse. As a new ingredient of SAMs, we introduce the effects of dynamical response to supernova-induced gas removal on size and velocity dispersion, which play an important role on dwarf galaxy formation. In previous theoretical studies of dwarf galaxies based on the monolithic cloud collapse given by Yoshii & Arimoto and Dekel & Silk, the dynamical response was treated in the extremes of a purely baryonic cloud and a baryonic cloud fully supported by surrounding dark matter. To improve this simple treatment, in our previous paper, we formulated the dynamical response in more realistic, intermediate situations between the above extremes. While the effects of dynamical response depend on the mass fraction of removed gas from a galaxy, how much amount of the gas remains just after major merger depends on the star formation history. A variety of star formation histories are generated through the Monte Carlo realization of merging histories of dark halos, and it is found that our SAM naturally makes a wide variety of dwarf galaxies and their dispersed characteristics as observed. (Abridged)

  9. Adaptation and adaptability : expectant design for resilience in coastal urbanity

    E-Print Network [OSTI]

    Ruskeepää, Laura A. Delaney (Laura Ashley Delaney)

    2011-01-01

    What is the nature of and possibility for urban resiliency through adaptation? Adaptation implies responsiveness to phenomena that are disruptive to a system's functioning; it is a willful evolution in response to changed ...

  10. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  11. Adaptive sampler

    DOE Patents [OSTI]

    Watson, B.L.; Aeby, I.

    1980-08-26

    An adaptive data compression device for compressing data is described. The device has a frequency content, including a plurality of digital filters for analyzing the content of the data over a plurality of frequency regions, a memory, and a control logic circuit for generating a variable rate memory clock corresponding to the analyzed frequency content of the data in the frequency region and for clocking the data into the memory in response to the variable rate memory clock.

  12. Climate response to tropical cyclone-induced ocean mixing in an1 Earth system model of intermediate complexity2

    E-Print Network [OSTI]

    Climate response to tropical cyclone-induced ocean mixing in an1 Earth system model of intermediate system model of intermediate complexity. The parameterization is based on21 previously published global. Abstract19 We introduce a parameterization of ocean mixing by tropical cyclones (TCs) into20 an Earth

  13. ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS

    E-Print Network [OSTI]

    ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS MOODY T. CHU Abstract. The wavefront aberrations induced by atmospheric turbulence can severely degrade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions

  14. ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS

    E-Print Network [OSTI]

    ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS MOODY T. CHU \\Lambda Abstract. The wavefront aberrations induced by atmospheric turbulence can severely degrade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions

  15. Optical near-field induced visible response photoelectrochemical water splitting on nanorod TiO{sub 2}

    SciTech Connect (OSTI)

    Thu Hac Huong Le; Mawatari, Kazuma; Pihosh, Yuriy; Kitamori, Takehiko [Department of Applied Chemistry, Graduate School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan); Kawazoe, Tadashi; Yatsui, Takashi; Ohtsu, Motoichi [Department of Electrical Engineering and Information Systems, Graduate School of Engineering, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan); Tosa, Masahiro [Micro-Nano Component Materials Group, Materials Engineering Laboratory, National Institute for Materials Science (NIMS), Sengen 1-2-1, Tsukuba, Ibaraki 305-0047 (Japan)

    2011-11-21

    Here we report a way to induce the visible response of non-doped TiO{sub 2} in the photocatalytic electrochemical water splitting, which is achieved by utilizing the optical near-field (ONF) generated on nanorod TiO{sub 2}. The visible response is attributed to the ONF-induced phonon-assisted excitation process, in which TiO{sub 2} is excited by sub-bandgap photons via phonon energy. Our approach directly gets involved in the excitation process without chemical modification of materials; accordingly it is expected to have few drawbacks on the photocatalytic performance. This study may offer another perspective on the development of solar harvesting materials.

  16. Adapting the U.S. Domestic Radiological Emergency Response Process to an Overseas Incident: FRMAC Without the F

    SciTech Connect (OSTI)

    Blumenthal, Daniel J. [USDOE NA Office of Emergency Response; Bowman, David R. [USDOE NA Office of Emergency Response; Remick, Alan [USDOE NA Office of Emergency Response

    2012-05-01

    The earthquake and resulting tsunami in Japan led to a radiological release from the Fukushima Daiichi Nuclear Power Plan, which in turn resulted in the rapid activation and deployment by the U.S. Department of Energy National Nuclear Security Administration (DOE/NNSA) emergency response teams. These teams and those from other federal agencies are typically coordinated through the Federal Radiological Monitoring and Assessment Center (FRMAC) when responding to radiological incidents in the U.S. FRMAC is the body through which the collection, analysis, and assessment of environmental radiological data are coordinated and products released to decision makers. This article discusses DOE/NNSA’s role in the U.S. response to the Fukushima accident as it implemented its components of FRMAC in a foreign country, coordinated its assets, integrated with its federal partners, and collaborated with the Government of Japan. The technical details of the various data collections and analyses are covered in other articles of this issue.

  17. The field induced e{sub 31,f} piezoelectric and Rayleigh response in barium strontium titanate thin films

    SciTech Connect (OSTI)

    Garten, L. M., E-mail: lmg309@psu.edu; Trolier-McKinstry, S. [Department of Materials Science and Engineering and Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802 (United States)

    2014-09-29

    The electric field induced e{sub 31,f} piezoelectric response and tunability of Ba{sub 0.7}Sr{sub 0.3}TiO{sub 3} (70:30) and Ba{sub 0.6}Sr{sub 0.4}TiO{sub 3} (60:40) thin films on MgO and silicon was measured. The relative dielectric tunabilities for the 70:30 and 60:40 compositions on MgO were 83% and 70%, respectively, with a dielectric loss of less than 0.011 and 0.004 at 100?kHz. A linear increase in induced piezoelectricity to ?3.0?C/m{sup 2} and ?1.5?C/m{sup 2} at 110?kV/cm was observed in Ba{sub 0.6}Sr{sub 0.4}TiO{sub 3} on MgO and Ba{sub 0.7}Sr{sub 0.3}TiO{sub 3} on Si. Hysteresis in the piezoelectric and dielectric response of the 70:30 composition films was consistent with the positive irreversible dielectric Rayleigh coefficient. Both indicate a ferroelectric contribution to the piezoelectric and dielectric response over 40–80?°C above the global paraelectric transition temperature.

  18. Ultrafast terahertz-induced response of GeSbTe phase-change materials...

    Office of Scientific and Technical Information (OSTI)

    response is observed, quadratic in the terahertz field, followed by field-driven lattice heating, with Ohmic behavior up to 200 kVcm. Authors: Shu, Michael J. 1 ;...

  19. Response Growth With Sound Level in Auditory-Nerve Fibers After Noise-Induced Hearing Loss

    E-Print Network [OSTI]

    Heinz, Michael G.

    G. Heinz and Eric D. Young Center for Hearing Sciences and Department of Biomedical Engineering with sound level was compared in normal-hearing cats and in cats with a noise-induced hearing loss to test steeper rate-level func- tions with cochlear damage (heavy solid and dashed lines in Fig. 1B

  20. Molecular pathogenesis of Salmonella enterica serotype Typhimurium-induced inflammatory responses 

    E-Print Network [OSTI]

    Figueiredo, Josely Ferreira

    2009-05-15

    , indicating that the corresponding effector proteins (SipA, SopA, SopB, SopD and SopE2) are required to induce chemokines independent of flagellin. The S. typhimurium sipAsopABDE2 mutant complemented with sipA activated IL-8 expression at significantly higher...

  1. Response

    Broader source: Energy.gov (indexed) [DOE]

    Response SEAB Recommendations Related to the Evaluation of New Funding Constructs for Energy R&D in the Department of Energy Introduction Over the past seven years, the Department...

  2. Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: Role of male sex hormone

    SciTech Connect (OSTI)

    Kim, Young C. [College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Ku, Seoul (Korea, Republic of)], E-mail: youckim@snu.ac.kr; Yim, Hye K.; Jung, Young S. [College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Ku, Seoul (Korea, Republic of); Park, Jae H. [College of Veterinary Medicine, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Ku, Seoul (Korea, Republic of); Kim, Sung Y. [College of Pharmacy, Wonkwang University, 344-2 Shinyong-Dong, Iksan (Korea, Republic of)

    2007-08-15

    Injury to liver, resulting in loss of its normal physiological/biochemical functions, may adversely affect a secondary organ. We examined the response of the liver and kidney to chemical substances that require metabolic activation for their toxicities in mice with a preceding liver injury. Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities. In contrast, the renal toxicity of the challenging toxicants was elevated markedly in male, but not in female mice. Partial hepatectomy also induced similar changes in the hepatotoxicity and nephrotoxicity of a challenging toxicant, suggesting that the contrasting response of male liver and kidney was associated with the reduction of the hepatic metabolizing capacity. Carbon tetrachloride pretreatment or partial hepatectomy decreased the hepatic xenobiotic-metabolizing enzyme activities in both sexes but elevated the renal p-nitrophenol hydroxylase, p-nitroanisole O-demethylase and aminopyrine N-demethylase activities significantly only in male mice. Increases in Cyp2e1 and Cyp2b expression were also evident in male kidney. Castration of males or testosterone administration to females diminished the sex-related differences in the renal response to an acute liver injury. The results indicate that reduction of the hepatic metabolizing capacity induced by liver injury may render secondary target organs susceptible to chemical substances activated in these organs. This effect may be sex-specific. It is also suggested that an integrated approach should be taken for proper assessment of chemical hazards.

  3. Remote sensor response study in the regime of the microwave radiation-induced magnetoresistance oscillations

    SciTech Connect (OSTI)

    Ye, Tianyu; Mani, R. G. [Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia 30303 (United States)] [Department of Physics and Astronomy, Georgia State University, Atlanta, Georgia 30303 (United States); Wegscheider, W. [Laboratorium für Festkörperphysik, ETH Zürich, 8093 Zürich (Switzerland)] [Laboratorium für Festkörperphysik, ETH Zürich, 8093 Zürich (Switzerland)

    2013-11-04

    A concurrent remote sensing and magneto-transport study of the microwave excited two dimensional electron system (2DES) at liquid helium temperatures has been carried out using a carbon detector to remotely sense the microwave activity of the 2D electron system in the GaAs/AlGaAs heterostructure during conventional magneto-transport measurements. Various correlations are observed and reported between the oscillatory magnetotransport and the remotely sensed reflection. In addition, the oscillatory remotely sensed signal is shown to exhibit a power law type variation in its amplitude, similar to the radiation-induced magnetoresistance oscillations.

  4. Time-Resolved Imaging of Material Response Following Laser-Induced Breakdown in the Bulk and Surface of Fused Silica

    SciTech Connect (OSTI)

    Raman, R N; Negres, R A; DeMange, P; Demos, S G

    2010-02-04

    Optical components within high energy laser systems are susceptible to laser-induced material modification when the breakdown threshold is exceeded or damage is initiated by pre-existing impurities or defects. These modifications are the result of exposure to extreme conditions involving the generation of high temperatures and pressures and occur on a volumetric scale of the order of a few cubic microns. The response of the material following localized energy deposition, including the timeline of events and the individual processes involved during this timeline, is still largely unknown. In this work, we investigate the events taking place during the entire timeline in both bulk and surface damage in fused silica using a set of time-resolved microscopy systems. These microscope systems offer up to 1 micron spatial resolution when imaging static or dynamic effects, allowing for imaging of the entire process with adequate temporal and spatial resolution. These systems incorporate various pump-probe geometries designed to optimize the sensitivity for detecting individual aspects of the process such as the propagation of shock waves, near-surface material motion, the speed of ejecta, and material transformations. The experimental results indicate that the material response can be separated into distinct phases, some terminating within a few tens of nanoseconds but some extending up to about 100 microseconds. Overall the results demonstrate that the final characteristics of the modified region depend on the material response to the energy deposition and not on the laser parameters.

  5. Dynamical response to supernova-induced gas removal in two-component spherical galaxies

    E-Print Network [OSTI]

    Masahiro Nagashima; Yuzuru Yoshii

    2002-12-30

    We investigate dynamical response on size and velocity dispersion to mass loss by supernovae in formation of two-component spherical galaxies composed of baryon and dark matter. Three-dimensional deprojected de Vaucouleurs-like and exponential-like profiles for baryon, embedded in truncated singular isothermal and homogeneous profiles for dark matter, are considered. As a more realistic case, we also consider a dark matter profile proposed by Navarro, Frenk & White. For simplicity we assume that dark matter distribution is not affected by mass loss and that the change of baryonic matter distribution is homologous. We found that the degree of the response depends on the fraction of dark matter in the region where baryon is distributed, so that dwarf spheroidal galaxies would be affected even in a dark halo if they are formed by galaxy mergers in the envelope of the dark halo. Our results suggest that this scenario, combined with dynamical response, would make not only the observed trends but the dispersed characteristics of dwarf spheroidals.

  6. Response

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterestedReplacement-2-A Wholesale PowerNatural GasBreakoutResponse SEAB Recommendations

  7. Responsibility

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterestedReplacement-2-A Wholesale PowerNaturalEnergy Response

  8. A tale of two houses: the human dimension of demand response enabling technology from a case study of an adaptive wireless thermostat.

    E-Print Network [OSTI]

    Peffer, Therese; Arens, Edward A; Chen, Xue; Jang, Jaehwi; Auslander, David M.

    2008-01-01

    technology to enable residential Demand Response (DR) is aalternative model for a residential demand response enablinguse it. Existing Residential Demand Response (DR) Programs

  9. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levelsmore »of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.« less

  10. On adaptive non-linearity for color discrimination and chromatic adaptation

    E-Print Network [OSTI]

    Alleysson, David

    the physiology literature that the photoreceptors' response to light is non-linear and adaptive. However, we can corresponding color data. Adaptive non-linearity Photoreceptors are the light-sensitive elements of the humanOn adaptive non-linearity for color discrimination and chromatic adaptation David Alleysson

  11. Spectral Response of the Pulsationally-Induced Shocks in the Atmosphere of BW Vulpeculae

    E-Print Network [OSTI]

    Myron A. Smith; C. Simon Jeffery

    2002-10-08

    The star BW Vul excites an extremely strong radial pulsation that grows in its envelope and is responsible for visible shock features in the continuum flux and spectral line profiles emerging in the atmosphere At two phases separated by 0.8 cycles. Material propelled upwards in the atmosphere from the shock returns to the lower photosphere where it creates a second shock just before the start of the next cycle. We have obtained three nights of echelle data for this star over about 5 pulsation cycles (P = 0.201 days) in order to evaluate the effects of on a number of important lines in the spectrum, including the HeI 5875A and 6678A lines. These data were supplemented by archival high-dispersion IUE (UV) data from 1994. A comparison of profiles of the two HeI lines during the peak of the infall activity suggests that differences in the development of the blue wing at this time are due to heating and short-lived formations of an optically thin layer above the atmospheric region compressed by the infall. This discovery and the well-known decreases in equivalent widths of the CII 6578-83A doublet at the two shock phases, suggests that shock flattens the temperature gradient and produces heating in heating the upper atmosphere. Except for absorptions in the blue wings of the UV resonance lines, we find no evidence for sequential shock delays arriving at various regions of line formation of the photosphere (a "Van Hoof effect"). Phase lags cited by some former observers may be false indicators arising from varying degrees of desaturation of multiple lines, such as for the red HeI lines. In addition, an apparent lag in the equivalent width curve of lines arising from less excited atomic levels could instead be caused by post-shock cooling, followed by a rebound shock.

  12. COMMENTARY:Limits to adaptation

    SciTech Connect (OSTI)

    Preston, Benjamin L

    2013-01-01

    An actor-centered, risk-based approach to defining limits to social adaptation provides a useful analytic framing for identifying and anticipating these limits and informing debates over society s responses to climate change.

  13. Adaptive Sensitivity 1 Adaptive Sensitivity

    E-Print Network [OSTI]

    Ginosar, Ran

    1 Adaptive Sensitivity 1 Adaptive Sensitivity Ran Ginosar Introduction Solid state (and other) sensors have a limited dynamic range Din: where both thresholds are measured in terms of the light intensity (Dout is specified as the ratio of the output signals). Light Intensity Output Signal Saturation

  14. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    SciTech Connect (OSTI)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levels of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.

  15. Adaptive method with intercessory feedback control for an intelligent agent

    DOE Patents [OSTI]

    Goldsmith, Steven Y.

    2004-06-22

    An adaptive architecture method with feedback control for an intelligent agent provides for adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. An adaptive architecture method with feedback control for multiple intelligent agents provides for coordinating and adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. Re-programming of the adaptive architecture is through a nexus which coordinates reflexive and deliberator components.

  16. Adaptive sequential controller

    DOE Patents [OSTI]

    El-Sharkawi, Mohamed A. (Renton, WA); Xing, Jian (Seattle, WA); Butler, Nicholas G. (Newberg, OR); Rodriguez, Alonso (Pasadena, CA)

    1994-01-01

    An adaptive sequential controller (50/50') for controlling a circuit breaker (52) or other switching device to substantially eliminate transients on a distribution line caused by closing and opening the circuit breaker. The device adaptively compensates for changes in the response time of the circuit breaker due to aging and environmental effects. A potential transformer (70) provides a reference signal corresponding to the zero crossing of the voltage waveform, and a phase shift comparator circuit (96) compares the reference signal to the time at which any transient was produced when the circuit breaker closed, producing a signal indicative of the adaptive adjustment that should be made. Similarly, in controlling the opening of the circuit breaker, a current transformer (88) provides a reference signal that is compared against the time at which any transient is detected when the circuit breaker last opened. An adaptive adjustment circuit (102) produces a compensation time that is appropriately modified to account for changes in the circuit breaker response, including the effect of ambient conditions and aging. When next opened or closed, the circuit breaker is activated at an appropriately compensated time, so that it closes when the voltage crosses zero and opens when the current crosses zero, minimizing any transients on the distribution line. Phase angle can be used to control the opening of the circuit breaker relative to the reference signal provided by the potential transformer.

  17. Mitogen induced proliferative responses of lymphocytes from spot (Leiostomus xanthurus) exposed to polycyclic aromatic hydrocarbon contaminated environments

    SciTech Connect (OSTI)

    Faisal, M.; Marzouk, M.S.; Smith, C.L.; Huggett, R.J. (Virginia Institute of Marine Science, School of Marine Science, College of William Mary, Gloucester Point (United States))

    1991-01-01

    The marine fish spot, Leiostomus xanthurus, was collected from five sites in the lower Chesapeake Bay system representing a gradient of sediment polycyclic aromatic hydrocarbon (PAH) concentrations. The proliferative responses to mitogens by anterior kidney lymphocytes were assessed using (3H)-thymidine uptake by replicating DNA. The data show two different mitogen-dependent lymphocytic responses as the sediment PAH levels increase at the sampling sites; a suppression of the response to the T cell mitogens, concanavalin A (Con A) and phytohemagglutinin, and a sharp augmentation of the response to B cell mitogen, lipopolysaccharide (LPS), as well as to poke weed mitogen and peanut agglutinin. The magnitude of the lymphoproliferative responses correlated strongly with the total sediment PAH concentrations (r2 greater than 0.8). A similar correlation was also observed with 15 selected individual PAH compounds regardless of their molecular weights. By maintaining the fish in clean York River water for up to 24 weeks, it was possible to reverse the augmented proliferative responses to LPS of fish from all sampling sites and to increase the reduced responses to Con A, in fish from three sites, and partially in two sites where sediments were highly contaminated with PAH. These results suggest that the proliferative responses of fish lymphocytes to mitogens may be a potentially sensitive biomarker of exposure to, and effects of xenobiotics.

  18. Influence of adaptive mesh refinement and the hydro solver on shear-induced mass stripping in a minor-merger scenario

    E-Print Network [OSTI]

    Schmidt, W; Iapichino, L; Vazza, F; Almgren, A S

    2014-01-01

    We compare two different codes for simulations of cosmological structure formation to investigate the sensitivity of hydrodynamical instabilities to numerics, in particular, the hydro solver and the application of adaptive mesh refinement (AMR). As a simple test problem, we consider an initially spherical gas cloud in a wind, which is an idealized model for the merger of a subcluster or galaxy with a big cluster. Based on an entropy criterion, we calculate the mass stripping from the subcluster as a function of time. Moreover, the turbulent velocity field is analyzed with a multi-scale filtering technique. We find remarkable differences between the commonly used PPM solver with directional splitting in the Enzo code and an unsplit variant of PPM in the Nyx code, which demonstrates that different codes can converge to systematically different solutions even when using uniform grids. For the test case of an unbound cloud, AMR simulations reproduce uniform-grid results for the mass stripping quite well, although...

  19. Urban climate resilience : a global assessment of city adaptation plans

    E-Print Network [OSTI]

    Katich, Kristina Noel

    2009-01-01

    As policy makers accept climate change as an irrefutable threat, adaptation planning has emerged as a necessary action for countries, states, and municipalities. This thesis explores adaptive responses to climate change ...

  20. Strong vortex core pinning and Barkhausen-free magnetization response in thin Permalloy disks induced by implantation of 1 × 10{sup 4} Ga{sup +} ions

    SciTech Connect (OSTI)

    Fani Sani, F., E-mail: fanisani@ualberta.ca, E-mail: mark.freeman@ualberta.ca; Losby, J. E.; Diao, Z.; Parsons, L. C.; Burgess, J. A. J.; Hiebert, W. K.; Freeman, M. R., E-mail: fanisani@ualberta.ca, E-mail: mark.freeman@ualberta.ca [Department of Physics, University of Alberta, Edmonton, Alberta T6G 2G7 (Canada); National Institute for Nanotechnology (NINT), Edmonton, Alberta T6G 2M9 (Canada); Vick, D. [National Institute for Nanotechnology (NINT), Edmonton, Alberta T6G 2M9 (Canada)

    2014-05-07

    Artificial vortex core pinning sites are induced in thin Permalloy disks by point exposure to as few as 10?000 ions from a focused Ga{sup +} beam. These pinning sites yield a first-order change in the magnetization response of the disk. A single site can keep the vortex core pinned over an applied field range comparable to the vortex annihilation field of the unaltered disk. Several widely separated sites can work together to keep the core pinned in one place, while the Barkhausen effect is eliminated from the magnetization curve over a range approaching the saturation moment of the disk.

  1. Self-Adaptive Management of The Sleep Depths of Idle Nodes in Large Scale Systems to Balance Between Energy Consumption and Response Times

    E-Print Network [OSTI]

    Zhu, Hong

    U.S. electricity consumption or the output of about 15 typical power plants [2]. In 2007, the electricity consumption of global cloud computing was 623 billion kWh which is larger than the 5th largest Between Energy Consumption and Response Times Yongpeng Liu(1) , Hong Zhu(2) , Kai Lu(1) , Xiaoping Wang(1

  2. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone 

    E-Print Network [OSTI]

    Russell J.A.; McKay A.J.; Brunton P.J.; Ochedalski T.; Piastowska A.; Rebas E.; Lachowicz A.

    2009-05-01

    The hypothalamus-pituitary-adrenal (HPA) axis is the major neuroendocrine stress response system. Corticotropin-releasing hormone (CRH) neurons in the parvocellular paraventricular nucleus (pPVN) play a key role in ...

  3. A critical analysis of adaptation in Sorghum bicolor (L.) Moench 

    E-Print Network [OSTI]

    Spelletich, Anne Clare

    1985-01-01

    This study was designed to characterize the phenomena associated with tropically adapted (TA) and temperately adapted (TE) sorghums (Sorghum bicolor (L. ) Moench) and their response patterns across diverse environments, Previous research indicate a... distinction between adaptation types in regard to their growth and development. Morphologic and agronomic characteristics associated with TA and TE sorghums were examined to determine specific adaptation responses. TA cultivars included in this study were...

  4. Prediction of automotive turbocharger nonlinear dynamic forced response with engine-induced housing excitations: comparisons to test data 

    E-Print Network [OSTI]

    Maruyama, Ashley Katsumi

    2009-05-15

    (TCs) supported on semi-floating ring bearings (SFRBs). The thesis presents progress on the nonlinear modeling of rotor-bearing systems (RBSs) by including engine-induced TC housing excitations. Test data collected from an engine-mounted TC unit...

  5. Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation

    SciTech Connect (OSTI)

    Fu, Na; Su, Dian; Cort, John R.; Chen, Baowei; Xiong, Yijia; Qian, Weijun; Konopka, Allan; Bigelow, Diana J.; Squier, Thomas C.

    2013-03-06

    Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic pathways in response to changing environmental conditions. To enable in vivo measurements of cellular redox changes linked to disulfide bond formation, we have synthesized a cell-permeable monosubstituted cyanine dye derivatized with arsenic (i.e., TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins. Alkylation of reactive thiols prior to displacement of the bound TRAP-Cy3 by ethanedithiol permits facile protein capture and mass spectrometric identification of proximal reduced dithiols to the exclusion of individual cysteines. Applying TRAP_Cy3 to evaluate cellular responses to increases in oxygen and light levels in the photosynthetic microbe Synechococcus sp. PCC 7002, we observe large decreases in the abundance of reduced dithiols in cellular proteins, which suggest redox-dependent mechanisms involving the oxidation of proximal disulfides. Under these same growth conditions that result in the oxidation of proximal thiols, there is a reduction in the abundance of post-translational oxidative modifications involving nitrotyrosine and methionine sulfoxide formation. These results suggest that the redox status of proximal cysteines respond to environmental conditions, acting to regulate metabolic flux and minimize the formation of reactive oxygen species to decrease oxidative protein damage.

  6. Skeletal adaptation to reduced mechanical loading

    E-Print Network [OSTI]

    Eliman, Rachel

    2014-01-01

    Bone adapts its mass and architecture in response to its mechanical environment. Yet control of this process by mechanical cues is poorly understood, particularly for unloading. Defining the fundamental mechanoregulation ...

  7. Cost-effective and highly sensitive cholesterol microsensors with fast response based on the enzyme-induced conductivity change of polyaniline

    SciTech Connect (OSTI)

    Fang, Kuan-Chung; Chu, Chia-Ho; Hsu, Chen-Pin; Kang, Yen-Wen; Fang, Jung-Ying; Chen, Chih-Chen; Li, Sheng-Shian; Andrew Yeh, J.; Yao, Da-Jeng; Wang, Yu-Lin, E-mail: ylwang@mx.nthu.edu.tw [Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 300, Taiwan (China); Hsu, Chia-Hsien [Division of Medical Engineering, National Health Research Institutes, MiaoLi, Taiwan (China); Huang, Yu-Fen [Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2014-09-15

    In this study, a cost-effective and highly sensitive cholesterol microsensor, which is consisted of cholesterol oxidase (ChOx), horseradish peroxidase (HRP), and polyaniline (PANI), was developed based on the enzyme-induced conductivity change of PANI with fast response. Hydrogen peroxide is produced via the reaction between cholesterol and ChOx, which was immobilized in a dialysis membrane. The produced hydrogen peroxide can oxidize HRP, which can be reduced by oxidizing PANI, thus resulting in decreased conductivity of the polyaniline thin film. The reduced HRP can be oxidized again by hydrogen peroxide and the cycle of the oxidation/reduction continues until all hydrogen peroxide are reacted, leading to the high sensitivity of the sensor due to the signal contributed from all hydrogen peroxide molecules. Cholesterol was detected near the physiological concentrations ranging from 100?mg/dl to 400?mg/dl with the cholesterol microsensors. The results show linear relation between cholesterol concentration and the conductivity change of the PANI. The microsensor showed no response to cholesterol when the PANI was standalone without cholesterol oxidase immobilized, indicating that the enzymatic reaction is required for cholesterol detection. The simple process of the sensor fabrication allows the sensor to be cost-effective and disposable usage. This electronic cholesterol microsensor is promising for point-of-care health monitoring in cholesterol level with low cost and fast response.

  8. Photo-induced change of dielectric response in BaCoSiO{sub 4} stuffed tridymite

    SciTech Connect (OSTI)

    Taniguchi, Hiroki Okamura, Takuma; Yamamoto, Takafumi; Okazaki, Ryuji; Terasaki, Ichiro; Moriwake, Hiroki; Kuwabara, Akihide; Itoh, Mitsuru

    2014-04-28

    The photodielectric effect is demonstrated in Mott-insulator BaCoSiO{sub 4} with a stuffed-tridymite-type structure under irradiation of visible light at 365?nm. The real part of dielectric permittivity is enhanced by ?300% with little increase of tan?? in a low-frequency region. Results of diffuse reflectance spectroscopy, first-principles calculations and dielectric measurements suggest that the photodielectric effect stems from a response of photo-excited electrons in an unoccupied upper-Hubbard band for 3d-orbitals of cobalt, which have significantly small mobility due to the unique configuration of Co ions in the stuffed-tridymite-type structure.

  9. Exact Expectation Analysis of the LMS Adaptive Filter \\Lambda

    E-Print Network [OSTI]

    Douglas, Scott C.

    Exact Expectation Analysis of the LMS Adaptive Filter \\Lambda Scott C. Douglas y and Weimin Pan analyses of the least­mean­square (LMS) adaptive filter, it is assumed that the filter coefficients that can be used to predict the exact statistical behavior of a finite­impulse­response (FIR) LMS adaptive

  10. Fidelity of adaptive phototaxis Knut Drescher, Raymond E. Goldstein1

    E-Print Network [OSTI]

    Goldstein, Raymond E.

    dis- plays an adaptive down-regulation in response to light, the colony needs to spin around itsFidelity of adaptive phototaxis Knut Drescher, Raymond E. Goldstein1 , and Idan Tuval Department by phototaxis assays in which colony rotation was slowed by increasing the fluid viscosity. adaptation

  11. Adaptation Plan 

    E-Print Network [OSTI]

    Durnbaugh, A.

    2011-01-01

    Response Update the extreme weather operation plan, focusing on vulnerable populations. Add climate-sensitive disease surveillance. Roads Pilot & implement new road materials to manage stormwater, decrease urban heat island effect, & maintain... and dry summers Source: Hayhoe et al. Journal of Great Lakes Research, 2010. Summers % changes relative to a 1961-1990 average ESL-KT-11-11-16 6 What is CCAP? Our goals to reduce Chicago?s greenhouse gas emissions and prepare for climate change?s...

  12. Generalized Adaptive A* Xiaoxun Sun

    E-Print Network [OSTI]

    Yeoh, William

    Generalized Adaptive A* Xiaoxun Sun USC Computer Science Los Angeles, California xiaoxuns spaces changes. Adaptive A* [7] is a Cite as: Generalized Adaptive A*, Xiaoxun Sun, Sven Koenig

  13. Augmentation of adaptation data 

    E-Print Network [OSTI]

    Vipperla, Ravi Chander; Renals, Steve; Frankel, Joe

    2010-01-01

    Linear regression based speaker adaptation approaches can improve Automatic Speech Recognition (ASR) accuracy significantly for a target speaker. However, when the available adaptation data is limited to a few seconds, the ...

  14. Noise Filtering Strategies of Adaptive Signaling Networks: The Case of E. Coli Chemotaxis

    E-Print Network [OSTI]

    Pablo Sartori; Yuhai Tu

    2011-04-20

    Two distinct mechanisms for filtering noise in an input signal are identi?ed in a class of adaptive sensory networks. We find that the high frequency noise is filtered by the output degradation process through time-averaging; while the low frequency noise is damped by adaptation through negative feedback. Both filtering processes themselves introduce intrinsic noises, which are found to be un?ltered and can thus amount to a significant internal noise floor even without signaling. These results are applied to E. coli chemotaxis. We show unambiguously that the molecular mechanism for the Berg-Purcell time-averaging scheme is the dephosphorylation of the response regulator CheY-P, not the receptor adaptation process as previously suggested. The high frequency noise due to the stochastic ligand binding-unbinding events and the random ligand molecule diffusion is averaged by the CheY-P dephosphorylation process to a negligible level in E.coli. We identify a previously unstudied noise source caused by the random motion of the cell in a ligand gradient. We show that this random walk induced signal noise has a divergent low frequency component, which is only rendered finite by the receptor adaptation process. For gradients within the E. coli sensing range, this dominant external noise can be comparable to the significant intrinsic noise in the system. The dependence of the response and its fluctuations on the key time scales of the system are studied systematically. We show that the chemotaxis pathway may have evolved to optimize gradient sensing, strong response, and noise control in di?erent time scales

  15. Using Opponent Modeling to Adapt Team Play in American Football

    E-Print Network [OSTI]

    Sukthankar, Gita Reese

    Using Opponent Modeling to Adapt Team Play in American Football Kennard R. Laviersa , Gita generation and real-time team response in the Rush 2008 American football simulator. Simultaneously of data-driven models. Keywords: opponent modeling; American football; play recognition; adaptive players

  16. A Computational Model for Adaptive Emotion Regulation

    E-Print Network [OSTI]

    Treur, Jan

    A Computational Model for Adaptive Emotion Regulation Tibor Bosse, Matthijs Pontier, and Jan Treur} Abstract. Emotion regulation describes how a subject can use certain strategies to affect emotion response levels. Usually, models for emotion regulation as- sume mechanisms based on feedback loops that indicate

  17. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

    E-Print Network [OSTI]

    Mangerich, Aswin

    Helicobacter hepaticus-infected Rag2-/- mice emulate many aspects of human inflammatory bowel disease, including the development of colitis and colon cancer. To elucidate mechanisms of inflammation-induced carcinogenesis, ...

  18. Dietary turmeric modulates DMBA-induced p21{sup ras}, MAP kinases and AP-1/NF-{kappa}B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    SciTech Connect (OSTI)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-11-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-{kappa}B, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-{kappa}B DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-{kappa}B, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements.

  19. Engineering Adaptive Web Applications

    E-Print Network [OSTI]

    Dolog, Peter

    Engineering Adaptive Web Applications Von Fakultät für Elektrotechnik und Informatik der Peter Dolog Engineering Adaptive Web Applications Dr. rer. nat. Dissertation 2006 #12;#12;Zusammenfassung: Nutzer von Web-Anwendungen stammen sich aus verschiedensten Nut- zergruppen, die sich in ihrem

  20. III International Climate Change Adaptation Adaptation Futures 2014

    E-Print Network [OSTI]

    1 III International Climate Change Adaptation Conference Adaptation Futures 2014 12-16 Maio 2014 sucesso da primeira conferência Climate Adaptation Futures realizada em Queensland, Austrália, em 2010 e

  1. Neuron, Vol. 26, 695702, June, 2000, Copyright 2000 by Cell Press Adaptive Rescaling Maximizes

    E-Print Network [OSTI]

    Brenner, Naama

    Information Transmission Adaptation to mean light level ensures that our visual responses are matchedNeuron, Vol. 26, 695­702, June, 2000, Copyright ©2000 by Cell Press Adaptive Rescaling Maximizes are stationary over some re-Adaptation is a widespread phenomenon in nervous gions, with slowly modulated

  2. Cellular/Molecular Light Adaptation in Salamander L-Cone Photoreceptors

    E-Print Network [OSTI]

    Rieke, Fred

    Cellular/Molecular Light Adaptation in Salamander L-Cone Photoreceptors Frederick S. Soo, Peter B,andanincreaseinguanylatecyclaseactivityduringthelightstepthatpersistsafterthelight is extinguished. Key words: photoreceptor; phototransduction; cone adaptation; retina adaptation; light; vision, Washington 98195 The responses of individual salamander L-cones to light steps of moderate intensity

  3. Optonanomechanical self-adaptive photonic devices based on light forces: A path to robust high-index-contrast nanophotonic circuits

    E-Print Network [OSTI]

    Popovic, Milos

    We describe a proposed new class of optonanomechanical integrated photonic devices that can have self-adaptive behavior and self-adaptive optical frequency response, through the use of optical forces to manipulate their ...

  4. Climate Change Adaptation

    Broader source: Energy.gov [DOE]

    DOE is adapting to climate change by applying a risk-based resiliency approach to identify and minimize climate-related vulnerabilities across all DOE policies, programs and activities.

  5. Rethinking adaptive reuse

    E-Print Network [OSTI]

    Benardete, Emma A., 1973-

    2002-01-01

    Adaptive reuse of manufacturing plants in post-industrial countries has become an increasing trend. In the United States, evidence of our industrial past is present in both urban and rural landscapes. The appearance of ...

  6. Postmodern film adaptation 

    E-Print Network [OSTI]

    Brannon, Courtney Elizabeth

    2013-02-22

    Chapter one explores the reflexive nature of Stephen Daldry's The Hours (2002) as an adaptation from two previous novels: Virginia Woolf's Mrs. Dalloway and Michael Cunningham's The Hours. Through the motif of mirror images, the film consciously...

  7. Climate Change Adaptation Planning

    Office of Energy Efficiency and Renewable Energy (EERE)

    This course provides an introduction to planning for climate change impacts, with examples of tribes that have been going through the adaptation planning process. The course is intended for tribal...

  8. Adaptive versus non-adaptive strategies for quantum channel discrimination

    E-Print Network [OSTI]

    Watrous, John

    Adaptive versus non-adaptive strategies for quantum channel discrimination Aram W. Harrow Avinatan-adaptive strategies for quantum channel discrimination. In particular, we give a pair of entanglement- breaking channels that can be perfectly discriminated by means of an adaptive strategy that re- quires just two

  9. Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: Probably an indirect action via the regulation of NF?B/FasL circuitry

    SciTech Connect (OSTI)

    Chen, Shiwei [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Dong, Yushu [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China)] [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China); Xu, Chun; Jiang, Liming; Chen, Yongjie; Jiang, Cheng [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Hou, Wugang, E-mail: gangwuhou@163.com [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China); Li, Wei, E-mail: liweipepeyato@163.com [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)

    2013-11-01

    Highlights: •MTA1 expression is upregulated in SCs upon MEHP treatment. •Knockdown of MTA1 in SCs impairs the MEHP-induced NF?B signaling activation. •Knockdown of MTA1 inhibits recruitment of NF?B onto FasL promoter in MEHP-treated SCs. -- Abstract: The Fas/FasL signaling pathway, controlled by nuclear factor-?B (NF?B) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), a component of the Mi-2/nucleosome remodeling and deacetylase complex, was upregulated in SCs during the early recovery after MEHP exposure. This expression change was in line with the dynamic changes in germ cell apoptosis in response to MEHP treatment. Furthermore, a knockdown of MTA1 by RNAi in SCs was found to impair the MEHP-induced early activation of NF?B pathway and abolish the recruitment of NF?B onto FasL promoter, which consequently diminished the MEHP-triggered FasL induction. Considering that Fas/FasL is a well characterized apoptosis initiating signaling during SCs injury, our results point to a potential “switch on” effect of MTA1, which may govern the activation of NF?B/FasL cascade in MEHP-insulted SCs. Overall, the MTA1/NF?B/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after SCs injury.

  10. Strain-induced kinetics of intergrain defects as the mechanism of slow dynamics in the nonlinear resonant response of humid sandstone bars

    E-Print Network [OSTI]

    resonant response of humid sandstone bars Oleksiy O. Vakhnenko,1 Vyacheslav O. Vakhnenko,2 Thomas J of sandstone bars, namely, (i) hysteretic behavior of a resonance curve on both its upward and downward slopes strain. In order to reproduce the highly nonlinear elastic features of sandstone grained structure

  11. Carbon dioxide effects research and assessment program. Environmental and societal consequences of a possible CO/sub 2/-induced climate change: volume II, part I. Response of the West Antarctic ice sheet to CO/sub 2/-induced climatic warming

    SciTech Connect (OSTI)

    Bentley, C.

    1982-04-01

    The paper proposes a research plan to deal with the question of what the response of the West Antarctic Ice Sheet would be to a rise in global temperatures caused by an anthropogenic CO/sub 2/ buildup in the atmosphere. The plan is designed to answer the following questions: (1) how fast is the ice mass changing now, and why; (2) how will the boundary conditions that affect the ice sheet respond to an atmospheric temperature change and how are those boundary conditions changing now; (3) what will be the response of the ice sheet to changes in boundary conditions; and (4) what can be learned by analogy with what has happened in the past. (ACR)

  12. On Statistical Analysis of the Pattern of Evolution of Perceived Emotions Induced by Hindustani Music- A Study Based on Listener Responses

    E-Print Network [OSTI]

    Midya, Vishal; Manna, Srijita; Sengupta, Ranjan

    2015-01-01

    The objective of this study is to find the underlying pattern of how perception of emotions has evolved in India. Here Hindustani Music has been used as a reference frame for tracking the changing perception of emotions. It has been found that different emotions perceived from Hindustani Music form a particular sequential pattern when their corresponding pitch periods are analyzed using the standard deviations and mean successive squared differences.This sequential pattern of emotions coincides with their corresponding sequential pattern of tempos or average number of steady states. On the basis of this result we further found that the range of perception of emotions has diminished significantly these days compared to what it was before. The proportion of responses for the perceived emotions like Anger, Serenity, Romantic and Sorrow has also decreased to a great extent than what it was previously. The proportion of responses for the perceived emotion Anxiety has increased phenomenally. Both standard deviation...

  13. CONTRIBUTED Adaptive Stochastic Control

    E-Print Network [OSTI]

    Powell, Warren B.

    sources, many forms of energy storage, and microgrid management (see Fig. 1). Computationally, controlling that are extremely close to optimal. We then address the problem of energy storage (e.g., in a large batteryCONTRIBUTED P A P E R Adaptive Stochastic Control for the Smart Grid The main theme of this paper

  14. Adaptive parallel computing with

    E-Print Network [OSTI]

    Pernet, Clément

    was prototyped #12;Urbana / dec 2009 9 C++ Elision struct Fibonacci { void operator()( int n, a1::Shared_wint1, a1::Shared_rint> sr2 ) { result.write( sr1.read() + sr2.read() ); } } #12;Urbana / dec 2009 10 C;Urbana / dec 2009 3 ·To mutually adapt application and scheduling · Extension to target GPU & MPSoC Kaapi

  15. Adaptive versus non-adaptive strategies for quantum channel discrimination

    E-Print Network [OSTI]

    Aram W. Harrow; Avinatan Hassidim; Debbie W. Leung; John Watrous

    2009-09-01

    We provide a simple example that illustrates the advantage of adaptive over non-adaptive strategies for quantum channel discrimination. In particular, we give a pair of entanglement-breaking channels that can be perfectly discriminated by means of an adaptive strategy that requires just two channel evaluations, but for which no non-adaptive strategy can give a perfect discrimination using any finite number of channel evaluations.

  16. A MATHEMATICAL FRAMEWORK FOR THE LINEAR RECONSTRUCTOR PROBLEM IN ADAPTIVE OPTICS

    E-Print Network [OSTI]

    A MATHEMATICAL FRAMEWORK FOR THE LINEAR RECONSTRUCTOR PROBLEM IN ADAPTIVE OPTICS MOODY T. CHU induced by atmospheric turbulence can severely de- grade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions in real time, i

  17. A MATHEMATICAL FRAMEWORK FOR THE LINEAR RECONSTRUCTOR PROBLEM IN ADAPTIVE OPTICS

    E-Print Network [OSTI]

    A MATHEMATICAL FRAMEWORK FOR THE LINEAR RECONSTRUCTOR PROBLEM IN ADAPTIVE OPTICS MOODY T. CHU aberrations induced by atmospheric turbulence can severely de­ grade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions in real time, i

  18. III International Climate Change Adaptation Adaptation Futures 2014

    E-Print Network [OSTI]

    1 III International Climate Change Adaptation Conference Adaptation Futures 2014 12-16 May 2014 of Research on Climate Change Vulnerability, Impacts and Adaptation (PROVIA), the Co and reports from the conference in newspapers 93 #12;4 1. INTRODUCTION Climate

  19. Evolving Recursive Programs by Using Adaptive Grammar Based Genetic Programming

    E-Print Network [OSTI]

    Fernandez, Thomas

    Page 1 Evolving Recursive Programs by Using Adaptive Grammar Based Genetic Programming Man Leung@ln.edu.hk Abstract Genetic programming (GP) extends traditional genetic algorithms to automatically induce computer programs. GP has been applied in a wide range of applications such as software re- engineering, electrical

  20. Energy dissipation in an adaptive molecular circuit

    E-Print Network [OSTI]

    Shou-Wen Wang; Yueheng Lan; Lei-Han Tang

    2015-05-28

    The ability to monitor nutrient and other environmental conditions with high sensitivity is crucial for cell growth and survival. Sensory adaptation allows a cell to recover its sensitivity after a transient response to a shift in the strength of extracellular stimulus. The working principles of adaptation have been established previously based on rate equations which do not consider fluctuations in a thermal environment. Recently, G. Lan et al. (Nature Phys., 8:422-8, 2012) performed a detailed analysis of a stochastic model for the E. coli sensory network. They showed that accurate adaptation is possible only when the system operates in a nonequilibrium steady-state (NESS). They further proposed an energy-speed-accuracy (ESA) trade-off relation. We present here analytic results on the NESS of the model through a mapping to a one-dimensional birth-death process. An exact expression for the entropy production rate is also derived. Based on these results, we are able to discuss the ESA relation in a more general setting. Our study suggests that the adaptation error can be reduced exponentially as the methylation range increases. Finally, we show that a nonequilibrium phase transition exists in the infinite methylation range limit, despite the fact that the model contains only two discrete variables.

  1. Response of Atmospheric Biomarkers to NOx-induced Photochemistry Generated by Stellar Cosmic Rays for Earth-like Planets in the Habitable Zone of M-Dwarf Stars

    E-Print Network [OSTI]

    Grenfell, John Lee; von Paris, Philip; Patzer, Beate; Lammer, Helmut; Stracke, Barbara; Gebauer, Stefanie; Schreier, Franz; Rauer, Heike

    2015-01-01

    Understanding whether M-dwarf stars may host habitable planets with Earth-like atmospheres and biospheres is a major goal in exoplanet research. If such planets exist, the question remains as to whether they could be identified via spectral signatures of biomarkers. Such planets may be exposed to extreme intensities of cosmic rays that could perturb their atmospheric photochemistry. Here, we consider stellar activity of M-dwarfs ranging from quiet up to strong flaring conditions and investigate one particular effect upon biomarkers, namely, the ability of secondary electrons caused by stellar cosmic rays to break up atmospheric molecular nitrogen (N2), which leads to production of nitrogen oxides in the planetary atmosphere, hence affecting biomarkers such as ozone. We apply a stationary model, that is, without a time-dependence, hence we are calculating the limiting case where the atmospheric chemistry response time of the biomarkers is assumed to be slow and remains constant compared with rapid forcing by t...

  2. Climate Change, Adaptation, and Development

    E-Print Network [OSTI]

    Cole, Daniel H.

    2008-01-01

    Climate Change, Adaptation, and Development Daniel H. Cole*THE COSTS OF CLIMATE CHANGE . ADAPTATIONCONVENTION ON CLIMATE CHANGE . IV. A.

  3. Id-1 is induced in MDCK epithelial cells by activated Erk/MAPK pathway in response to expression of the Snail and E47 transcription factors

    SciTech Connect (OSTI)

    Jorda, Mireia [IDIBELL-Institut de Recerca Oncologica, Centre d'Oncologia Molecular, Barcelona (Spain); Vinyals, Antonia [IDIBELL-Institut de Recerca Oncologica, Centre d'Oncologia Molecular, Barcelona (Spain); Marazuela, Anna [IDIBELL-Institut de Recerca Oncologica, Centre d'Oncologia Molecular, Barcelona (Spain); Cubillo, Eva [Instituto de Investigaciones Biomedicas 'Alberto Sols' (CSIC-UAM) and Departamento de Bioquimica (UAM), Madrid (Spain); Olmeda, David [Instituto de Investigaciones Biomedicas 'Alberto Sols' (CSIC-UAM) and Departamento de Bioquimica (UAM), Madrid (Spain); Valero, Eva [IDIBELL-Institut de Recerca Oncologica, Centre d'Oncologia Molecular, Barcelona (Spain); Cano, Amparo [Instituto de Investigaciones Biomedicas 'Alberto Sols' (CSIC-UAM) and Departamento de Bioquimica (UAM), Madrid (Spain); Fabra, Angels [IDIBELL-Institut de Recerca Oncologica, Centre d'Oncologia Molecular, Barcelona (Spain)]. E-mail: afabra@idibell.org

    2007-07-01

    Id-1, a member of the helix-loop-helix transcription factor family has been shown to be involved in cell proliferation, angiogenesis and invasion of many types of human cancers. We have previously shown that stable expression of E47 and Snail repressors of the E-cadherin promoter in MDCK epithelial cell line triggers epithelial mesenchymal transition (EMT) concomitantly with changes in gene expression. We show here that both factors activate the Id-1 gene promoter and induce Id-1 mRNA and protein. The upregulation of the Id-1 gene occurs through the transactivation of the promoter by the Erk/MAPK signaling pathway. Moreover, oncogenic Ras is also able to activate Id-1 promoter in MDCK cells in the absence of both E47 and Snail transcription factors. Several transcriptionally active regulatory elements have been identified in the proximal promoter, including AP-1, Sp1 and four putative E-boxes. By EMSA, we only detected an increased binding to Sp1 and AP-1 elements in E47- and Snail-expressing cells. Binding is affected by the treatment of cells with PD 98059 MEK inhibitor, suggesting that MAPK/Erk contributes to the recruitment or assembly of proteins to Id-1 promoter. Small interfering RNA directed against Sp1 reduced Id-1 expression and the upregulation of the promoter, indicating that Sp1 is required for Id-1 induction in E47- and Snail-expressing cells. Our results provide new insights into how some target genes are activated during and/or as a consequence of the EMT triggered by both E47 and Snail transcription factors.

  4. Adaptive control for accelerators

    DOE Patents [OSTI]

    Eaton, Lawrie E. (Los Alamos, NM); Jachim, Stephen P. (Los Alamos, NM); Natter, Eckard F. (Santa Fe, NM)

    1991-01-01

    An adaptive feedforward control loop is provided to stabilize accelerator beam loading of the radio frequency field in an accelerator cavity during successive pulses of the beam into the cavity. A digital signal processor enables an adaptive algorithm to generate a feedforward error correcting signal functionally determined by the feedback error obtained by a beam pulse loading the cavity after the previous correcting signal was applied to the cavity. Each cavity feedforward correcting signal is successively stored in the digital processor and modified by the feedback error resulting from its application to generate the next feedforward error correcting signal. A feedforward error correcting signal is generated by the digital processor in advance of the beam pulse to enable a composite correcting signal and the beam pulse to arrive concurrently at the cavity.

  5. Semantic Responsibility 

    E-Print Network [OSTI]

    Toribio, Josefa

    2002-01-01

    In this paper I attempt to develop a notion of responsibility (semantic responsibility) that is to the notion of belief what epistemic responsibility is to the notion of justification. 'Being semantically responsible' ...

  6. Acquired tolerance in cadmium-adapted lung epithelial cells: Roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein

    SciTech Connect (OSTI)

    Lau, Andy T.Y. [Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong (China); Zhang Jian [Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT 05405 (United States); Chiu, J.-F. [Department of Anatomy, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong (China) and Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT 05405 (United States)]. E-mail: jfchiu@hkucc.hku.hk

    2006-08-15

    Cadmium-resistant cells were developed in our laboratory with rat lung epithelial cells (LECs) by stepwise exposure of LECs to cadmium chloride from 1 {mu}M to 20 {mu}M after 20 passages. To investigate the Cd-resistant phenotype in a long-term perspective, cadmium-resistant cells adapted to 20 {mu}M cadmium (Cd{sup R}) were then cultured in the absence of cadmium for various passages [Cd{sup R}(-n)]. All these adapted cells were significantly protected from cadmium toxicity as compared to parental cadmium-sensitive LECs (Cd{sup S}). The cadmium-resistant phenotype of adapted cells was relatively stable in the absence of cadmium for as long as 40 passages. Basal mRNA level of metallothionein-1 (MT-1) was dramatically higher in Cd{sup R} than in Cd{sup R}(-), which may account for the higher Cd-resistance of Cd{sup R} than Cd{sup R}(-). MT-1 mRNA level decreased drastically in Cd{sup R} after cadmium removal, suggesting that the high basal level of MT-1 in Cd{sup R} may be only partially responsible for cadmium-resistance. Treatment of cells with high levels of cadmium resulted in decreased phosphorylation of c-Jun N-terminal kinase (JNK1/2) in adapted cells than in sensitive cells and this cadmium-induced JNK activity was blocked by JNK inhibitor II, SP600125. Ro318220, a strong activator of JNK, reverted cadmium-sensitive phenotype in adapted cells. Taken together, our results suggest that during cadmium adaptation, cells develop tolerance to cell death, generally due to perturbation of the JNK signaling pathway and the nonresponsiveness of JNK phosphorylation is critical for the Cd-tolerance in these cells.

  7. Friends or Foes? A Conceptual Analysis of Self-Adaptation and IT Change Management

    E-Print Network [OSTI]

    Newcastle upon Tyne, University of

    -Adaptation and IT Change Management Cristina Gacek, Holger Giese and Ethan Hadar Abstract Self-Adaptation as a vision the current practice in ITIL Change Management as initial reference point. We define the required responsibilities and a generic conceptual object model and map them to the ITIL Change Management roles to evaluate

  8. Adaptive FIR Filtering of Range Sidelobes for Air and Spaceborne Rain Mapping Stephen P. Lohmeier

    E-Print Network [OSTI]

    Kansas, University of

    Adaptive FIR Filtering of Range Sidelobes for Air and Spaceborne Rain Mapping Stephen P. Lohmeier and Telecommunications Center Abstract ­ This paper describes an adaptive finite-impulse response (FIR) filteringB [1] sidelobe levels. Although others have used wavelets to achieve suppression [2]. To measure light

  9. Predator induced defenses in prey with diverse predators 

    E-Print Network [OSTI]

    Garza, Mark Isaac

    2006-04-12

    Phenotypic plasticity is an environmentally based change in phenotype and can be adaptive. Often, the change in an organism's phenotype is induced by the presence of a predator and serves as a defense against that predator. Defensive phenotypes...

  10. Involvement of caspase-12-dependent apoptotic pathway in ionic radiocontrast urografin-induced renal tubular cell injury

    SciTech Connect (OSTI)

    Wu, Cheng Tien [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Weng, Te I. [Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Chen, Li Ping [Department of Dentistry, Chang Gang Memorial Hospital, Chang Gang University, Taoyuan, Taiwan (China)] [Department of Dentistry, Chang Gang Memorial Hospital, Chang Gang University, Taoyuan, Taiwan (China); Chiang, Chih Kang [Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China) [Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Liu, Shing Hwa, E-mail: shinghwaliu@ntu.edu.tw [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Department of Urology, National Taiwan University Hospital, Taipei, Taiwan (China)

    2013-01-01

    Contrast medium (CM) induces a direct toxic effect on renal tubular cells. This toxic effect subjects in the disorder of CM-induced nephropathy. Our previous work has demonstrated that CM shows to activate the endoplasmic reticulum (ER)-related adaptive unfolding protein response (UPR) activators. Glucose-regulated protein 78 (GRP78)/eukaryotic initiation factor 2? (eIF2?)-related pathways play a protective role during the urografin (an ionic CM)-induced renal tubular injury. However, the involvement of ER stress-related apoptotic signals in the urografin-induced renal tubular cell injury remains unclear. Here, we examined by the in vivo and in vitro experiments to explore whether ER stress-regulated pro-apoptotic activators participate in urografin-induced renal injury. Urografin induced renal tubular dilation, tubular cells detachment, and necrosis in the kidneys of rats. The tubular apoptosis, ER stress-related pro-apoptotic transcriptional factors, and kidney injury marker-1 (kim-1) were also conspicuously up-regulated in urografin-treated rats. Furthermore, treatment of normal rat kidney (NRK)-52E tubular cells with urografin augmented the expressions of activating transcription factor-6 (ATF-6), C/EBP homologous protein (CHOP), Bax, caspase-12, JNK, and inositol-requiring enzyme (IRE) 1 signals. Urografin-induced renal tubular cell apoptosis was not reversed by the inhibitors of ATF-6, JNK signals or CHOP siRNA transfection, but it could be partially reversed by the inhibitor of caspase-12. Taken together, the present results and our previous findings suggest that exposure of CM/urografin activates the ER stress-regulated survival- and apoptosis-related signaling pathways in renal tubular cells. Caspase-12-dependent apoptotic pathway may be partially involved in the urografin-induced nephropathy. -- Highlights: ? Ionic contrast medium-urografin induces renal tubular cell apoptosis. ? Urografin induces the ER stress-regulated survival and apoptosis signals. ? Caspase-12 signaling participates in urografin-induced renal cell apoptosis.

  11. TOWARDS SELF-ADAPTABLE MONITORING FRAMEWORK FOR SELF-HEALING

    E-Print Network [OSTI]

    Alonso, Javier

    TOWARDS SELF-ADAPTABLE MONITORING FRAMEWORK FOR SELF-HEALING Javier Alonso and Jordi Torres of ex- ternal metrics about the system such as performance, memory consumption or response time. However-Oriented Programming, Self-monitoring, Self-healing #12;2 1. Introduction The benefits of including effective

  12. Adaptive Energy Forecasting and Information Diffusion for Smart Power Grids

    E-Print Network [OSTI]

    Hwang, Kai

    1 Adaptive Energy Forecasting and Information Diffusion for Smart Power Grids Yogesh Simmhan. One of the characteristic applications of Smart Grids is demand response optimization (DR). The goal of DR is to use the power consumption time series data to reliable forecast the future consumption

  13. Making climate adaptation work : strategies for resource constrained South Asian mega-cities

    E-Print Network [OSTI]

    Dutta-Koehler, Madhu Chhanda

    2013-01-01

    This dissertation compares the responses of Dhaka, Bangladesh and Kolkata, India to the serious challenges posed by climate change, particularly in the water sector. Drawing on the theories of "adaptation as development" ...

  14. Emerging patterns of adaptive re-use : the new American House Hotel

    E-Print Network [OSTI]

    Moody, Linda A

    1984-01-01

    This thesis aims to develop a design solution for the adaptive reuse of the American House Hotel that answers an architectural design challenge with technical responses. The process of actualization has been pushed a bit ...

  15. Demand Response for Ancillary Services

    SciTech Connect (OSTI)

    Alkadi, Nasr E; Starke, Michael R

    2013-01-01

    Many demand response resources are technically capable of providing ancillary services. In some cases, they can provide superior response to generators, as the curtailment of load is typically much faster than ramping thermal and hydropower plants. Analysis and quantification of demand response resources providing ancillary services is necessary to understand the resources economic value and impact on the power system. Methodologies used to study grid integration of variable generation can be adapted to the study of demand response. In the present work, we describe and illustrate a methodology to construct detailed temporal and spatial representations of the demand response resource and to examine how to incorporate those resources into power system models. In addition, the paper outlines ways to evaluate barriers to implementation. We demonstrate how the combination of these three analyses can be used to translate the technical potential for demand response providing ancillary services into a realizable potential.

  16. Demand Response for Ancillary Services

    Broader source: Energy.gov [DOE]

    Methodologies used to study grid integration of variable generation can be adapted to the study of demand response. In the present work, we describe and implement a methodology to construct detailed temporal and spatial representations of demand response resources and to incorporate those resources into power system models. In addition, the paper outlines ways to evaluate barriers to implementation. We demonstrate how the combination of these three analyses can be used to assess economic value of the realizable potential of demand response for ancillary services.

  17. Adaptation, Learning, and Optimization over

    E-Print Network [OSTI]

    California at Los Angeles, University of

    Adaptation, Learning, and Optimization over Networks Ali H. Sayed University of California at Los 2014 A. H. Sayed DOI: 10.1561/2200000051 Adaptation, Learning, and Optimization over Networks Ali H . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.6 Notation and Symbols . . . . . . . . . . . . . . . . . . . . 8 2 Optimization by Single Agents

  18. Adaptive Signal Processing Course Information

    E-Print Network [OSTI]

    Tsakalides, Panagiotis

    of the theory to a variety of practical problems such as interference and echo cancellation, signal and system least squares adaptive algorithms 2 Properties of RLS 2 Applications: ADPCM speech encoding Non-Linear. Understanding of the theoretical foundations of adaptive signal processing theory will be achieved through

  19. Fire-induced growth responses of huisache 

    E-Print Network [OSTI]

    Rasmussen, George Allen

    1981-01-01

    to applications of the herbicide to unburned rangeland (Bontrager 1977). Fire can be used to improve access or "clean up" an area of debris from previous treatments (Britton and Wright 1971). Removal of stems reduced livestock handling problems in addition... in June 1979 snd with a new set burned every other month until April 1980. Sampling stations composed of four plants each. (tnree ourned and one unburned) were established with one burned tree enclosed to allow access only +o rodents, lagomorphs...

  20. Wind-induced dynamic response of bridges

    E-Print Network [OSTI]

    Rousseau, Guillaume, 1982-

    2004-01-01

    Wind loading has long played a significant role in bridge design. Some spectacular failures, such as the Tay Bridge (Scotland, 1879), or the Tacoma Narrows Bridge (Washington State, 1940) acted as a painful reminder to ...

  1. Mechanisms of radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.

    1996-10-01

    In the process of identifying genes differentially expressed in cells exposed ultraviolet radiation, we have identified a transcript having a 26-bp region that is highly conserved in a variety of species including Bacillus circulans, yeast, pumpkin, Drosophila, mouse, and man. When the 5` region (flanking region or UTR) of a gene, the sequence is predominantly in +/+ orientation with respect to the coding DNA strand; while in the coding region and the 3` region (UTR), the sequence is most frequently in the +/-orientation with respect to the coding DNA strand. In two genes, the element is split into two parts; however, in most cases, it is found only once but with a minimum of 11 consecutive nucleotides precisely depicting the original sequence. The element is found in a large number of different genes with diverse functions (from human ras p21 to B. circulans chitonase). Gel shift assays demonstrated the presence of a protein in HeLa cell extracts that binds to the sense and antisense single-stranded consensus oligomers, as well as to the double- stranded oligonucleotide. When double-stranded oligomer was used, the size shift demonstrated as additional protein-oligomer complex larger than the one bound to either sense or antisense single-stranded consensus oligomers alone. It is speculated either that this element binds to protein(s) important in maintaining DNA is a single-stranded orientation for transcription or, alternatively that this element is important in the transcription-coupled DNA repair process.

  2. Adaptive Optics in Star Formation

    E-Print Network [OSTI]

    Wolfgang Brandner

    2003-09-29

    Over the past ten years, the concept of adaptive optics has evolved from early experimental stages to a standard observing tool now available at almost all major optical and near-infrared telescope facilities. Adaptive optics will also be essential in exploiting the full potential of the large optical/infrared interferometers currently under construction. Both observations with high-angular resolution and at high contrast, and with a high point source sensitivity are facilitated by adaptive optics. Among the areas which benefit most from the use of adaptive optics are studies of the circumstellar environment (envelopes, disks, outflows), substellar companions and multiple systems, and dense young stellar populations. This contribution highlights some of the recent advances in star formation studies facilitated by adaptive optics, and gives a brief tutorial on optimized observing and data reduction strategies.

  3. Adaptable architecture : a computational exploration into responsive design systems

    E-Print Network [OSTI]

    Zulas, Alejandro, 1976-

    2004-01-01

    Based on the fact that architecture is, among other things, the crystallization of a mediation among design intentions (function), meaning and contextual constraints (performance), we as designers are obligated to produce ...

  4. Adaptive liquid microlenses activated by stimuli-responsive hydrogels

    E-Print Network [OSTI]

    Beebe, David J.

    ), are also readily integrated into arrays that may find use in applications such as sensing, medical diagnostics and lab-on-a-chip technologies15­19 . In our system, we use the meniscus between water and oil centred over the ring. The microchannels are filled with water, and oil is placed on top of this structure

  5. Automated Grid Disruption Response System: Robust Adaptive Topology Control (RATC)

    SciTech Connect (OSTI)

    2012-03-01

    GENI Project: The RATC research team is using topology control as a mechanism to improve system operations and manage disruptions within the electric grid. The grid is subject to interruption from cascading faults caused by extreme operating conditions, malicious external attacks, and intermittent electricity generation from renewable energy sources. The RATC system is capable of detecting, classifying, and responding to grid disturbances by reconfiguring the grid in order to maintain economically efficient operations while guaranteeing reliability. The RATC system would help prevent future power outages, which account for roughly $80 billion in losses for businesses and consumers each year. Minimizing the time it takes for the grid to respond to expensive interruptions will also make it easier to integrate intermittent renewable energy sources into the grid.

  6. A Dynamic Platform for Runtime Adaptation

    E-Print Network [OSTI]

    Pham, Hubert

    We present a middleware platform for assembling pervasive applications that demand fault-tolerance and adaptivity in distributed, dynamic environments. Unlike typical adaptive middleware approaches, in which sophisticated ...

  7. Adaptive multiconfigurational wave functions

    SciTech Connect (OSTI)

    Evangelista, Francesco A.

    2014-03-28

    A method is suggested to build simple multiconfigurational wave functions specified uniquely by an energy cutoff ?. These are constructed from a model space containing determinants with energy relative to that of the most stable determinant no greater than ?. The resulting ?-CI wave function is adaptive, being able to represent both single-reference and multireference electronic states. We also consider a more compact wave function parameterization (?+SD-CI), which is based on a small ?-CI reference and adds a selection of all the singly and doubly excited determinants generated from it. We report two heuristic algorithms to build ?-CI wave functions. The first is based on an approximate prescreening of the full configuration interaction space, while the second performs a breadth-first search coupled with pruning. The ?-CI and ?+SD-CI approaches are used to compute the dissociation curve of N{sub 2} and the potential energy curves for the first three singlet states of C{sub 2}. Special attention is paid to the issue of energy discontinuities caused by changes in the size of the ?-CI wave function along the potential energy curve. This problem is shown to be solvable by smoothing the matrix elements of the Hamiltonian. Our last example, involving the Cu{sub 2}O{sub 2}{sup 2+} core, illustrates an alternative use of the ?-CI method: as a tool to both estimate the multireference character of a wave function and to create a compact model space to be used in subsequent high-level multireference coupled cluster computations.

  8. Automating component reuse and adaptation

    E-Print Network [OSTI]

    Alexander, Perry; Morel, B.

    2004-09-01

    framework for automating specification-based component retrieval and adaptation that has been successfully applied to synthesis of software for embedded and digital signal processing systems. Using specifications to abstractly represent implementations...

  9. Standard Templates Adaptive Parallel Library 

    E-Print Network [OSTI]

    Arzu, Francisco Jose

    2000-01-01

    STAPL (Standard Templates Adaptive Parallel Library) is a parallel C++ library designed as a superset of the C++ Standard Template Library (STL), sequentially consistent for functions with the same name, and executed on uni- or multi- processor...

  10. Electricity Markets Meet the Home through Demand Response Lazaros Gkatzikis

    E-Print Network [OSTI]

    Electricity Markets Meet the Home through Demand Response Lazaros Gkatzikis CERTH, University Hegde, Laurent Massouli´e Technicolor Paris Research Lab Paris, France Abstract-- Demand response (DR the alternative option of dynamic demand adaptation. In this direction, demand response (DR) programs provide

  11. Evaluation of Fatigue Resistance in Alaskan Sled Dogs Through Exercise Induced Myocyte Gene Expression 

    E-Print Network [OSTI]

    Salazar, Natacha Maria

    2012-02-14

    The physiological responses to exercise depend on intensity, duration, and type of exercise. The muscles in the body have complex regulation responses in order to create a certain resistance and adaptation to the exercise ...

  12. Mutations in global regulators lead to metabolic selection during adaptation to complex environments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Saxer, Gerda; Krepps, Michael D.; Merkley, Eric D.; Ansong, Charles; Deatherage Kaiser, Brooke L.; Valovska, Marie -Thérèse; Ristic, Nikola; Yeh, Ping T.; Prakash, Vittal P.; Leiser, Owen P.; et al

    2014-12-11

    Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Unlike adaptation to a single limiting resource, adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes since many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased geneticmore »and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that a subtle modulation of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order “metabolic selection” that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a “one-step” mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.« less

  13. Optimal Adaptive Waveform Selection for Target Tracking

    E-Print Network [OSTI]

    Rezaeian, Mohammad-Jafar

    seeking to detect submarine periscopes in the presence of sea clutter. The simplest scheme for adaptive

  14. Climate Change Adaptation for Local Government

    E-Print Network [OSTI]

    Pedersen, Tom

    Climate Change Adaptation for Local Government A Resource Guide June 2011 Jenny Fraser, Adaptation Specialist, Climate Action Secretariat, BC Ministry of Environment & Matthew Strand, Researcher, Adaptation to Climate Change Team, Simon Fraser University #12;Page 1 of 26 Climate Change Adaptation for Local

  15. Lactose-Inducible System for Metabolic Engineering of Clostridium ljungdahlii

    SciTech Connect (OSTI)

    Banerjee, A; Leang, C; Ueki, T; Nevin, KP; Lovley, DR

    2014-03-25

    The development of tools for genetic manipulation of Clostridium ljungdahlii has increased its attractiveness as a chassis for autotrophic production of organic commodities and biofuels from syngas and microbial electrosynthesis and established it as a model organism for the study of the basic physiology of acetogenesis. In an attempt to expand the genetic toolbox for C. ljungdahlii, the possibility of adapting a lactose-inducible system for gene expression, previously reported for Clostridium perfringens, was investigated. The plasmid pAH2, originally developed for C. perfringens with a gusA reporter gene, functioned as an effective lactose-inducible system in C. ljungdahlii. Lactose induction of C. ljungdahlii containing pB1, in which the gene for the aldehyde/alcohol dehydrogenase AdhE1 was downstream of the lactose-inducible promoter, increased expression of adhE1 30-fold over the wild-type level, increasing ethanol production 1.5-fold, with a corresponding decrease in acetate production. Lactose-inducible expression of adhE1 in a strain in which adhE1 and the adhE1 homolog adhE2 had been deleted from the chromosome restored ethanol production to levels comparable to those in the wild-type strain. Inducing expression of adhE2 similarly failed to restore ethanol production, suggesting that adhE1 is the homolog responsible for ethanol production. Lactose-inducible expression of the four heterologous genes necessary to convert acetyl coenzyme A (acetyl-CoA) to acetone diverted ca. 60% of carbon flow to acetone production during growth on fructose, and 25% of carbon flow went to acetone when carbon monoxide was the electron donor. These studies demonstrate that the lactose-inducible system described here will be useful for redirecting carbon and electron flow for the biosynthesis of products more valuable than acetate. Furthermore, this tool should aid in optimizing microbial electrosynthesis and for basic studies on the physiology of acetogenesis.

  16. Adaptive Liquid Crystal Windows

    SciTech Connect (OSTI)

    Taheri, Bahman; Bodnar, Volodymyr

    2011-12-31

    Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft × 1ft prototype panels for the world’s first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicron’s patented e-Tint® technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of power consumption by ALCWs allows for on-board power electronics for automatic matching of transmission through windows to varying climate conditions without drawing the power from the power grid. ALCWs are capable of transmitting more sunlight in winters to assist in heating and less sunlight in summers to minimize overheating. As such, they can change the window from being a source of energy loss to a source of energy gain. In addition, the scalable AMI’s roll-to-roll process, proved by making 1ft × 1ftALCW prototype panels, allows for cost-effective production of large-scale window panels along with capability to change easily their color and shape. In addition to architectural glazing in houses and commercial buildings, ALCWs can be used in other applications where control of sunlight is needed, such as green houses, used by commercial produce growers and botanical gardens, cars, aircrafts, etc.

  17. Spatial dynamics of adaptive sex ratios According to Fisherian sex allocation theory, parents that can adjust their offspring

    E-Print Network [OSTI]

    Lummaa, Virpi

    Spatial dynamics of adaptive sex ratios Abstract According to Fisherian sex allocation theory, parents that can adjust their offspring sex ratio in response to skews in population sex ratio will maximize their fitness over parents lacking this ability. There is good evidence that adaptive sex ratio

  18. Submillisecond-response polymer network liquid crystal phase modulators at 1.06-lm wavelength

    E-Print Network [OSTI]

    Wu, Shin-Tson

    is the increased operating voltage. Potential applications include spatial light modulators and adaptive optics. VC modulators are useful for adaptive optics,1 spatial light modulators,2 and switchable displays.3 The response online 15 July 2011) A fast-response and scattering-free polymer network liquid crystal (PNLC) light

  19. Benefits of Demand Response in Electricity Markets and Recommendations...

    Office of Environmental Management (EM)

    incentive payments designed to induce lower electricity use at times of high market prices or when grid reliability is jeopardized. Benefits of Demand Response in Electricity...

  20. Training Adaptive Decision-Making.

    SciTech Connect (OSTI)

    Abbott, Robert G.; Forsythe, James C.

    2014-10-01

    Adaptive Thinking has been defined here as the capacity to recognize when a course of action that may have previously been effective is no longer effective and there is need to adjust strategy. Research was undertaken with human test subjects to identify the factors that contribute to adaptive thinking. It was discovered that those most effective in settings that call for adaptive thinking tend to possess a superior capacity to quickly and effectively generate possible courses of action, as measured using the Category Generation test. Software developed for this research has been applied to develop capabilities enabling analysts to identify crucial factors that are predictive of outcomes in fore-on-force simulation exercises.

  1. Adaptive Optics for Large Telescopes

    SciTech Connect (OSTI)

    Olivier, S

    2008-06-27

    The use of adaptive optics was originally conceived by astronomers seeking to correct the blurring of images made with large telescopes due to the effects of atmospheric turbulence. The basic idea is to use a device, a wave front corrector, to adjust the phase of light passing through an optical system, based on some measurement of the spatial variation of the phase transverse to the light propagation direction, using a wave front sensor. Although the original concept was intended for application to astronomical imaging, the technique can be more generally applied. For instance, adaptive optics systems have been used for several decades to correct for aberrations in high-power laser systems. At Lawrence Livermore National Laboratory (LLNL), the world's largest laser system, the National Ignition Facility, uses adaptive optics to correct for aberrations in each of the 192 beams, all of which must be precisely focused on a millimeter scale target in order to perform nuclear physics experiments.

  2. Crowdsourcing affective responses for predicting media effectiveness

    E-Print Network [OSTI]

    McDuff, Daniel Jonathan

    2014-01-01

    Emotion is key to the effectiveness of media, whether it be in influencing memory, likability or persuasion. Stories and narratives, even if fictional, have the ability to induce a genuine emotional response. However, the ...

  3. The optimal thermo-optical properties and energy saving potential of adaptive glazing technologies

    E-Print Network [OSTI]

    Favoino, Fabio; Overend, Mauro; Jin, Qian

    2015-06-17

    system can be self-powered. An evolution of PEC is represented by photo-volta-chromic (PVC), which differs from PEC in that the photovoltaic and electrochromic functions can be separated, thereby facilitating its integration with building management sys... of adaptive or Responsive Building Elements and systems, which passively or actively adjust their thermo-optical properties or operation in a reversible way in order to adapt to changing outdoor/indoor environmental conditions (i.e. solar radiation, air...

  4. Adaptive wiener image restoration kernel

    DOE Patents [OSTI]

    Yuan, Ding (Henderson, NV)

    2007-06-05

    A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

  5. diploma thesis Adaptive Building Intelligence

    E-Print Network [OSTI]

    Rutishauser, Ueli

    diploma thesis Adaptive Building Intelligence A multi-Agent approach Ueli Rutishauser Alain Sch intelligent. A building is perceived as be- ing intelligent if it is able to learn from experience. We is connected to the sensors and effectors via a dedicated fieldbus network (LonWorks). Based on this data

  6. Adaptive protection algorithm and system

    DOE Patents [OSTI]

    Hedrick, Paul (Pittsburgh, PA) [Pittsburgh, PA; Toms, Helen L. (Irwin, PA) [Irwin, PA; Miller, Roger M. (Mars, PA) [Mars, PA

    2009-04-28

    An adaptive protection algorithm and system for protecting electrical distribution systems traces the flow of power through a distribution system, assigns a value (or rank) to each circuit breaker in the system and then determines the appropriate trip set points based on the assigned rank.

  7. Viewing Conditions and Chromatic Adaptation

    E-Print Network [OSTI]

    Majumder, Aditi

    Linear nonlinear #12;2 Viewing field Self-luminous displays CRT, LCD Reflective media Painting Viewing: Adapting stimulus Subscript E: Equal energy illumination #12;13 Fairchild's model (1991) Inter channel brightness #12;6 11 Definition of Color Appearance Model so much description of color such as: wavelength

  8. 2014 DOE Climate Change Adaptation Plan | Department of Energy

    Office of Environmental Management (EM)

    Climate Change Adaptation Plan 2014 DOE Climate Change Adaptation Plan Document presents the U.S. Department of Energy (DOE) 2014 plan for adapting to climate change....

  9. Multi-model adaptive spatial hypertext 

    E-Print Network [OSTI]

    Francisco-Revilla, Luis

    2005-02-17

    Information delivery on the Web often relies on general purpose Web pages that require the reader to adapt to them. This limitation is addressed by approaches such as spatial hypermedia and adaptive hypermedia. Spatial hypermedia augments...

  10. CLIMATE VULNERABILITY AND ADAPTATION STUDY FOR

    E-Print Network [OSTI]

    CLIMATE VULNERABILITY AND ADAPTATION STUDY FOR CALIFORNIA Legal Analysis of Barriers's California Climate Change Center JULY 2012 CEC5002012019 Prepared for: California Energy Commission to that framework that would facilitate adaptation to climate change. Since such changes may be difficult

  11. Adaptive control of Unmanned Aerial Systems

    E-Print Network [OSTI]

    Dydek, Zachary Thompson

    2010-01-01

    Adaptive control is considered to be one of the key enabling technologies for future high-performance, safety-critical systems such as air-breathing hypersonic vehicles. Adaptive flight control systems offer improved ...

  12. EXACT WAVEFRONT CORRECTION IN ADAPTIVE OPTICS.

    E-Print Network [OSTI]

    Rosier, Lionel - Institut de Mathématiques �lie Cartan, Université Henri Poincaré

    EXACT WAVEFRONT CORRECTION IN ADAPTIVE OPTICS. Pierre Le Gall Lionel Rosier Institut Elie Cartan an adaptive optical system in which a deformable mirror is controlled to compensate for random wavefront c 2005 IFAC Keywords: Adaptive optics, exact wavefront correction, membrane mirror. 1. INTRODUCTION

  13. Interferometry following adaptive optics Erez N. Ribak

    E-Print Network [OSTI]

    Ribak, Erez

    Interferometry following adaptive optics Erez N. Ribak Department of Physics, Technion, Haifa 32000, Israel ABSTRACT Adaptive optics systems on single big telescopes correct many modes, allowing imaging, adaptive optics, big telescopes, shearing interferometry. 1. THE IMPROVEMENT OF THE WAVE FRONT Most big

  14. 1/18/2002 1 SelfSelf--Adaptive Discovery MechanismsAdaptive Discovery Mechanisms

    E-Print Network [OSTI]

    Mills, Kevin

    1/18/2002 1 SelfSelf--Adaptive Discovery MechanismsAdaptive Discovery Mechanisms for Improved, simulate, and evaluate self-adaptive algorithms to improve performance of discovery protocols regarding software Project ObjectiveProject Objective Research, design, evaluate, and implement self-adaptive

  15. Adaptation and Identity of Yolmo

    E-Print Network [OSTI]

    Pokharel, Binod

    2005-01-01

    of tourist and establishment of hotels. To cope with the increasing firewood demand the people have planted trees on the edge of the agricultural land and LNP introduced solar energy to reduce the rate of firewood consumption. Timber is used basically... the adaptive mechanism of the households. He contends that the number of children in a households influence the diversification of the household economy. In this regards Fricke writes: 96 Occasional Papers The household labour force is largely determined...

  16. Adaptive Stabilization of Nonlinear Stochastic Systems

    SciTech Connect (OSTI)

    Florchinger, P. [URA CNRS No. 399, Departement de Mathematiques, UFR MIM, Universite de Metz, Ile du Saulcy, F 57045 Metz Cedex (France)

    1998-07-15

    The purpose of this paper is to study the problem of asymptotic stabilization in probability of nonlinear stochastic differential systems with unknown parameters. With this aim, we introduce the concept of an adaptive control Lyapunov function for stochastic systems and we use the stochastic version of Artstein's theorem to design an adaptive stabilizer. In this framework the problem of adaptive stabilization of a nonlinear stochastic system is reduced to the problem of asymptotic stabilization in probability of a modified system. The design of an adaptive control Lyapunov function is illustrated by the example of adaptively quadratically stabilizable in probability stochastic differential systems.

  17. Center for Adaptive Optics* Santa Cruz,CA

    E-Print Network [OSTI]

    Grether, Gregory

    Center for Adaptive Optics* Santa Cruz,CA The Center for Adaptive Optics (CfAO) will concentrate on astronomical and vision science applications of adaptive optics and will reach out to other adaptive optics communities to share technologies. It will develop new instruments optimized for adaptive optics. Adaptive

  18. Adaptive capture of expert behavior

    SciTech Connect (OSTI)

    Jones, R.D.; Barrett, C.L.; Hand, U.; Gordon, R.C.

    1994-08-01

    The authors smoothed and captured a set of expert rules with adaptive networks. The motivation for doing this is discussed. (1) Smoothing leads to stabler control actions. (2) For some sets of rules, the evaluation of the rules can be sped up. This is important in large-scale simulations where many intelligent elements are present. (3) Variability of the intelligent elements can be achieved by adjusting the weights in an adaptive network. (4) After capture has occurred, the weights can be adjusted based on performance criteria. The authors thus have the capability of learning a new set of rules that lead to better performance. The set of rules the authors chose to capture were based on a set of threat determining rules for tank commanders. The approach in this paper: (1) They smoothed the rules. The rule set was converted into a simple set of arithmetic statements. Continuous, non-binary inputs, are now permitted. (2) An operational measure of capturability was developed. (3) They chose four candidate networks for the rule set capture: (a) multi-linear network, (b) adaptive partial least squares, (c) connectionist normalized local spline (CNLS) network, and (d) CNLS net with a PLS preprocessor. These networks were able to capture the rule set to within a few percent. For the simple tank rule set, the multi-linear network performed the best. When the rules were modified to include more nonlinear behavior, CNLS net performed better than the other three nets which made linear assumptions. (4) The networks were tested for robustness to input noise. Noise levels of plus or minus 10% had no real effect on the network performance. Noise levels in the plus or minus 30% range degraded performance by a factor of two. Some performance enhancement occurred when the networks were trained with noisy data. (5) The scaling of the evaluation time was calculated. (6) Human variation can be mimicked in all the networks by perturbing the weights.

  19. Performance of a MEMS-base Adaptive Optics Optical Coherency Tomography System

    SciTech Connect (OSTI)

    Evans, J; Zadwadzki, R J; Jones, S; Olivier, S; Opkpodu, S; Werner, J S

    2008-01-16

    We have demonstrated that a microelectrical mechanical systems (MEMS) deformable mirror can be flattened to < 1 nm RMS within controllable spatial frequencies over a 9.2-mm aperture making it a viable option for high-contrast adaptive optics systems (also known as Extreme Adaptive Optics). The Extreme Adaptive Optics Testbed at UC Santa Cruz is being used to investigate and develop technologies for high-contrast imaging, especially wavefront control. A phase shifting diffraction interferometer (PSDI) measures wavefront errors with sub-nm precision and accuracy for metrology and wavefront control. Consistent flattening, required testing and characterization of the individual actuator response, including the effects of dead and low-response actuators. Stability and repeatability of the MEMS devices was also tested. An error budget for MEMS closed loop performance will summarize MEMS characterization.

  20. Adaptive management: a paradigm for remediation of public facilities

    SciTech Connect (OSTI)

    Janecky, David R; Whicker, Jeffrey J; Doerr, Ted B

    2009-01-01

    Public facility restoration planning traditionally focused on response to natural disasters and hazardous materials accidental releases. These plans now need to integrate response to terrorist actions. Therefore, plans must address a wide range of potential vulnerabilities. Similar types of broad remediation planning are needed for restoration of waste and hazardous material handling areas and facilities. There are strong similarities in damage results and remediation activities between unintentional and terrorist actions; however, the uncertainties associated with terrorist actions result in a re-evaluation of approaches to planning. Restoration of public facilities following a release of a hazardous material is inherently far more complex than in confined industrial settings and has many unique technical, economic, social, and political challenges. Therefore, they arguably involve a superset of drivers, concerns and public agencies compared to other restoration efforts. This superset of conditions increases complexity of interactions, reduces our knowledge of the initial conditions, and even condenses the timeline for restoration response. Therefore, evaluations of alternative restoration management approaches developed for responding to terrorist actions provide useful knowledge for large, complex waste management projects. Whereas present planning documents have substantial linearity in their organization, the 'adaptive management' paradigm provides a constructive parallel operations paradigm for restoration of facilities that anticipates and plans for uncertainty, multiple/simUltaneous public agency actions, and stakeholder participation. Adaptive management grew out of the need to manage and restore natural resources in highly complex and changing environments with limited knowledge about causal relationships and responses to restoration actions. Similarities between natural resource management and restoration of a facility and surrounding area(s) after a disruptive event suggest numerous advantages over preset linearly-structured plans by incorporating the flexibility and overlap of processes inherent in effective facility restoration. We discuss three restoration case studies (e.g., the Hart Senate Office Building anthrax restoration, Rocky Flats actinide remediation, and hurricane destruction restoration), that implement aspects of adaptive management but not a formal approach. We propose that more formal adoption of adaptive management principles could be a basis for more flexible standards to improve site-specific remediation plans under conditions of high uncertainty.

  1. vol. 166, supplement the american naturalist october 2005 Testosterone in Females: Mediator of Adaptive Traits,

    E-Print Network [OSTI]

    Ketterson, Ellen D.

    of Adaptive Traits, Constraint on Sexual Dimorphism, or Both? E. D. Ketterson,1,* V. Nolan Jr.,1, and M could constrain dimorphism. Results from birds, including the dark-eyed junco (Junco hyemalis), reveal of sexual dimorphism. Keywords: hormonal pleiotropy, correlated responses, sex differences, hormonal

  2. Climate Change Adaptation: New Perspectives for Natural Resource Management and Conservation1

    E-Print Network [OSTI]

    Mazzotti, Frank

    WEC318 Climate Change Adaptation: New Perspectives for Natural Resource Management and Conservation/IFAS Extension. A Changing Climate for Conservation Climate change is creating new challenges for conservation their distributions in response to climate change, and changes in phenology are disrupting ecological relationships

  3. Self-Adaptive Power Management of Idle Nodes in Large Scale Systems

    E-Print Network [OSTI]

    Zhu, Hong

    Self-Adaptive Power Management of Idle Nodes in Large Scale Systems YONGPENG LIU(1) , HONG ZHU(2 with multiple level dynamic sleep mechanisms to reduce power consumption. However, awaking sleeping nodes takes to balance between the systems energy consumption and the response time is a key problem in the power

  4. The Snowball Effect: Detailing Performance Anomalies of 802.11 Rate Adaptation

    E-Print Network [OSTI]

    Trappe, Wade

    to remedy such rate adaptation failures, there has not been a thorough analysis of the causes that lead of transmission failures, and consequently invoke improper responses that cascade to dramatic throughput application, and provide recommendations for the next generation of WiFi rate control schemes. I. INTRODUCTION

  5. Hormetic Effect Induced by Alpha-Particle-Induced Stress Communicated In Vivo between Zebrafish Embryos

    E-Print Network [OSTI]

    Yu, Peter K.N.

    response (RAR) by communica- tion of radiation-induced bystander signals.5 RAR is a low-dose effect, which to a low-dose alpha-particle irradiation can release a stress signal into the water, which can-response relationships exhibiting a low-dose stimulation and a high-dose inhibition. The effects on the whole embryos

  6. Response Elements

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-07-11

    The Guide provides acceptable methods for meeting the requirement of DOE O 151.1C for response elements that respond or contribute to response as needed in an emergency. Supersedes DOE G 151.1-1, Volume 3-1, DOE G 151.1-1, Volume 3-2, DOE G 151.1-1, Volume 3-3, DOE G 151.1-1, Volume 3-4, DOE G 151.1-1, Volume 4-1, DOE G 151.1-1, Volume 4-2, DOE G 151.1-1, Volume 4-3, DOE G 151.1-1, Volume 4-4, DOE G 151.1-1, Volume 4-5, and DOE G 151.1-1, Volume 4-6.

  7. AN ADAPTIVE FINITE ELEMENT METHOD FOR THE ...

    E-Print Network [OSTI]

    2015-06-30

    Scattering theory in periodic structures, which is crucial in application .... is used to design the adaptive finite element algorithm to choose elements for refine-.

  8. Training for Climate Adaptation in Conservation

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Wildlife Conservation Society and the Northern Institute of Applied Climate Science are hosting this two-day training for climate adaptation.

  9. Assessing Climate Change Impacts, Vulnerability and Adaptation...

    Open Energy Info (EERE)

    Assessing Climate Change Impacts, Vulnerability and Adaptation: The Case of Pantabangan-Carranglan Watershed Jump to: navigation, search Name Assessing Climate Change Impacts,...

  10. Mainstreaming Climate Change Adaptation into Development Planning...

    Open Energy Info (EERE)

    Mainstreaming Climate Change Adaptation into Development Planning: A Guide for Practitioners Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Mainstreaming Climate Change...

  11. Protein Structure Suggests Role as Molecular Adapter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Role as Molecular Adapter Print To split and copy DNA during replication, all cellular organisms use a multicomponent molecular machine known as the replisome. An essential...

  12. Mutations in global regulators lead to metabolic selection during adaptation to complex environments

    SciTech Connect (OSTI)

    Saxer, Gerda; Krepps, Michael D.; Merkley, Eric D.; Ansong, Charles; Deatherage Kaiser, Brooke L.; Valovska, Marie -Thérèse; Ristic, Nikola; Yeh, Ping T.; Prakash, Vittal P.; Leiser, Owen P.; Nakhleh, Luay; Gibbons, Henry S.; Kreuzer, Helen W.; Shamoo, Yousif; Matic, Ivan

    2014-12-11

    Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Unlike adaptation to a single limiting resource, adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes since many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that a subtle modulation of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order “metabolic selection” that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a “one-step” mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.

  13. A Geometric Characterization of the Power of Finite Adaptability in Multistage Stochastic and Adaptive Optimization

    E-Print Network [OSTI]

    Bertsimas, Dimitris J.

    In this paper, we show a significant role that geometric properties of uncertainty sets, such as symmetry, play in determining the power of robust and finitely adaptable solutions in multistage stochastic and adaptive ...

  14. AdaptUbiFlow: Selection and Adaptation in Workflows for Ubiquitous Computing Frederico Lopes, Thiago Pereira,

    E-Print Network [OSTI]

    Ferreira, Paulo

    AdaptUbiFlow: Selection and Adaptation in Workflows for Ubiquitous Computing Frederico Lopes will be chosen. AdaptUbiFlow evaluation showed encouraging results Keywords--Ubiquitous computing, platform The current trend in ubiquitous computing is the emergence of complex context-aware applications in which

  15. Downhole tool adapted for telemetry

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Fox, Joe (Provo, UT)

    2010-12-14

    A cycleable downhole tool such as a Jar, a hydraulic hammer, and a shock absorber adapted for telemetry. This invention applies to other tools where the active components of the tool are displaced when the tool is rotationally or translationally cycled. The invention consists of inductive or contact transmission rings that are connected by an extensible conductor. The extensible conductor permits the transmission of the signal before, after, and during the cycling of the tool. The signal may be continuous or intermittent during cycling. The invention also applies to downhole tools that do not cycle, but in operation are under such stress that an extensible conductor is beneficial. The extensible conductor may also consist of an extensible portion and a fixed portion. The extensible conductor also features clamps that maintain the conductor under stresses greater than that seen by the tool, and seals that are capable of protecting against downhole pressure and contamination.

  16. Optimized multifrequency light collection by adaptive self-ordering of scatterers in optical resonators

    E-Print Network [OSTI]

    Torggler, Valentin

    2014-01-01

    Mobile light scatterers in a high-Q optical cavity transversely illuminated by laser light close to a cavity resonance form ordered patterns, which maximize light scattering into the cavity and induce optical self-trapping. We show that a generalized form of such crystallization dynamics appears in multicolored pump fields with several cavity modes. Here the particles arrange in spatial patterns maximizing total light collection into the resonator. For changing input frequencies and strengths the particles dynamically adapt to the current illumination. Interestingly the system keeps some memory on past configurations, so that a later renewed application of the same pattern exhibits faster adaptation towards optimal collective scattering. In a noisy environment particles explore larger regions of configuration space spending most of the time close to optimum scattering configurations. This adaptive self-ordering dynamics should be implementable in a wide range of systems ranging from cold atoms in multimode ca...

  17. Enabling Informed Adaptation of Reformed Instructional Materials

    E-Print Network [OSTI]

    Elby, Andy

    Enabling Informed Adaptation of Reformed Instructional Materials Rachel E. Scherr and Andrew Elby 20742 USA Abstract. Instructors inevitably need to adapt even the best reform materials to suit instructors, and video clips of students working on the materials. Our materials thus facilitate their own

  18. Adaptive Communication Agent for Group Communication activities

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , limited energy resources), system execute adaptive mechanisms by monitoring the data flow. Also, the actor-wide collaborative environment, managing the adaptive communication is a challenging task. It implies the monitoring and executed without manual intervention. This research is applied to a Crisis Management System (CMS) within

  19. RESEARCH ARTICLE Adaptive Resistance in Bacteria Requires

    E-Print Network [OSTI]

    Cluzel, Philippe

    RESEARCH ARTICLE Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps. PLoS ONE 10, Cambridge, Massachusetts, United States of America * max@fis.unam.mx Abstract Adaptive resistance emerges

  20. CLIMATE CHANGE ADAPTATIONS FOR LOCAL WATER MANAGEMENT

    E-Print Network [OSTI]

    CLIMATE CHANGE ADAPTATIONS FOR LOCAL WATER MANAGEMENT IN THE SAN FRANCISCO BAY AREA water managers can adapt by changing water supply portfolios and operations. An engineering economic A White Paper from the California Energy Commission's California Climate Change Center JULY 2012 CEC

  1. ADAPTIVE GRIDS IN WEATHER AND CLIMATE MODELING

    E-Print Network [OSTI]

    Jablonowski, Christiane

    ADAPTIVE GRIDS IN WEATHER AND CLIMATE MODELING by Christiane Jablonowski A dissertation submitted adaptive grid library that he wrote for his Ph.D. thesis in the Electrical Engineering and Computer Science as a postdoctoral researcher. In addition, thanks to Detlev Majewski from the German Weather Service DWD

  2. Adaptive User Profiles in Pervasive Advertising Environments

    E-Print Network [OSTI]

    Adaptive User Profiles in Pervasive Advertising Environments Florian Alt1 , Moritz Balz2 , Stefanie advertising environments try to provide more effi- cient ads by targeting costumers based on their interests. We implemented an advertising platform to simulate an advertising environment and present adaptive

  3. Adaptive Representation of Specular Light Flux

    E-Print Network [OSTI]

    Montréal, Université de

    Adaptive Representation of Specular Light Flux Normand Bri`ere Pierre Poulin D´epartement d in all but the simplest con- figurations. To capture their appearance, we present an adaptive approach based upon light beams. The coher- ence between light rays forming a light beam greatly re- duces

  4. A fuzzy-tuned adaptive Kalman filter 

    E-Print Network [OSTI]

    Painter, John H.; Young Hwan Lho

    1993-12-01

    In this paper, fuzzy processing is applied to the adaptive Kalman filter. The filter gain coefficients are adapted over a 50 dB range of unknown signal/noise dynamics, using fuzzy membership functions. Specific simulation results are shown for a...

  5. Formulating and Implementing Profiling over Adaptive Ranges

    E-Print Network [OSTI]

    Sherwood, Tim

    be implemented for range-adaptive profiling. RAP can be used on various profiles, such as PCs, load values may easily be lost in a sea of data. We present range-adaptive profiling (RAP) as a new and general value locality. We propose two methods of implementation of RAP, one in software and the other

  6. DIRECT ADAPTIVE CONTROL OF RESIN TRANSFER MOLDING

    E-Print Network [OSTI]

    Mamishev, Alexander

    of defects, control of mold filling is needed. In this paper, direct adaptive control strategy is presented is a crucial stage in RTM. Defect-free parts cannot be obtained without successful consistent mold fillingDIRECT ADAPTIVE CONTROL OF RESIN TRANSFER MOLDING B. Minaie1,* , W. Li, J. Gou1 , Y. Chen2 , A

  7. Adaptive Web Sites: Automatically Synthesizing Web Pages

    E-Print Network [OSTI]

    Etzioni, Oren

    Adaptive Web Sites: Automatically Synthesizing Web Pages Mike Perkowitz Oren Etzioni Department interfaces Abstract The creation of a complex web site is a thorny problem in user interface design. In IJCAI '97, we challenged the AI community to address this problem by creating adaptive web sites: sites

  8. Demand Response and Open Automated Demand Response

    E-Print Network [OSTI]

    LBNL-3047E Demand Response and Open Automated Demand Response Opportunities for Data Centers G described in this report was coordinated by the Demand Response Research Center and funded by the California. Demand Response and Open Automated Demand Response Opportunities for Data Centers. California Energy

  9. Rights-based evaluation of government responses to a given 'natural' disaster : Katrina as case study

    E-Print Network [OSTI]

    Haeffner, Melissa (Melissa Ann)

    2010-01-01

    Disaster impacts human mobility and a rights-based approach to disaster response is needed to protect the human rights of those who seek migration as an adaptation strategy. This paper deals with returning to a place after ...

  10. AUTHOR'S PERMISSION GUIDELINES Authors are responsible for obtaining permission from the copyright holder to

    E-Print Network [OSTI]

    Mateo, Jill M.

    to a specific period of time. require payment of renewal fees. place restrictions on access to the material are responsible for securing permission to reproduce or adapt any material for which they do not hold

  11. Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

    E-Print Network [OSTI]

    Santagata, Sandro

    Unlike normal tissues, cancers experience profound alterations in protein homeostasis. Powerful innate adaptive mechanisms, especially the transcriptional response regulated by Heat Shock Factor 1 (HSF1), are activated in ...

  12. Dscam gene expression in invertebrate immunity : alternative splicing in response to diverse pathogens 

    E-Print Network [OSTI]

    Smith, Paul Hugh

    2012-11-30

    Invertebrates show enhanced immunity and even specific primed immunity in response to repeat infections, analogous to vertebrate adaptive immunity. Little is known of the mechanism for this phenomenon, or which molecules ...

  13. Quantum gravitational optics: the induced phase

    E-Print Network [OSTI]

    N. Ahmadi; M. Nouri-Zonoz

    2007-03-26

    The geometrical approximation of the extended Maxwell equation in curved spacetime incorporating interactions induced by the vacuum polarization effects is considered. Taking into account these QED interactions and employing the analogy between eikonal equation in geometrical optics and Hamilton-Jacobi equation for the particle motion, we study the phase structure of the modified theory. There is a complicated, local induced phase which is believed to be responsible for the modification of the classical picture of light ray. The main features of QGO could be obtained through the study of this induced phase. We discuss initial principles in conventional and modified geometrical optics and compare the results.

  14. Adaptive-feedback spectral-phase control for interactions with transform-limited ultrashort high-power laser pulses

    E-Print Network [OSTI]

    Umstadter, Donald

    point of a 100-TW peak-power laser in vacuum. The spectral-phase distortion induced by the dispersion that use high-power laser pulses must be performed in vacuum in order to prevent degradation of the laserAdaptive-feedback spectral-phase control for interactions with transform-limited ultrashort high-power

  15. Note: On-line weak signal detection via adaptive stochastic resonance

    SciTech Connect (OSTI)

    Lu, Siliang; He, Qingbo Kong, Fanrang

    2014-06-15

    We design an instrument with a novel embedded adaptive stochastic resonance (SR) algorithm that consists of a SR module and a digital zero crossing detection module for on-line weak signal detection in digital signal processing applications. The two modules are responsible for noise filtering and adaptive parameter configuration, respectively. The on-line weak signal detection can be stably achieved in seconds. The prototype instrument exhibits an advance of 20 dB averaged signal-to-noise ratio and 5 times averaged adjust R-square as compared to the input noisy signal, in considering different driving frequencies and noise levels.

  16. Supplementary Material Learning optimal adaptation strategies in unpredictable motor tasks

    E-Print Network [OSTI]

    Supplementary Material Learning optimal adaptation strategies in unpredictable motor tasks D.A. Braun, A. Aertsen, D.M. Wolpert, C. Mehring Contents 1 Adaptive Optimal Control Methods 2 1-adaptive Optimal Control Models . . . . . . . . . . . . . . . . . 5 1.4 Arm Model

  17. Unifying the Sensory and Motor Components of Sensorimotor Adaptation 

    E-Print Network [OSTI]

    Haith, Adrian; Jackson, Carl; Miall, Chris; Vijayakumar, Sethu

    2008-01-01

    Adaptation of visually guided reaching movements in novel visuomotor environments (e.g. wearing prism goggles) comprises not only motor adaptation but also substantial sensory adaptation, corresponding to shifts in ...

  18. Probing young massive clusters with laser guide star adaptive optics

    E-Print Network [OSTI]

    McCrady, Nate

    2009-01-01

    laser guide star adaptive optics Nate McCrady Received: 10laser guide star adaptive optics (LGS/AO) on the 10 m Keckof 4 Mpc. Our adaptive optics work is motivated by three

  19. 2014 DOE Climate Change Adaptation Plan | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2014 DOE Climate Change Adaptation Plan 2014 DOE Climate Change Adaptation Plan Document presents the U.S. Department of Energy (DOE) 2014 plan for adapting to climate change....

  20. Adaptive Expertise and Contextualized Activities in Computer Aided Design 

    E-Print Network [OSTI]

    Ozturk, Elif

    2015-05-04

    , to determine the “baseline” adaptive expertise among the sample population, an adaptive expertise survey (AES) instrument is administered to both the practicing engineers and the students. The instrument contains questions defining four dimensions of adaptive...

  1. Rapid Evolution of Coral Proteins Responsible for Interaction with the Environment

    E-Print Network [OSTI]

    Voolstra, Christian R.

    2011-01-01

    AM (2010) Development and heat stress-induced transcriptomicTranscriptomic responses to heat stress and bleaching in thefaveolata) during heat stress. Mar Biotechnol (NY) 2: 533–

  2. NCRAWL: Network Coding for Rate Adaptive Wireless Links

    E-Print Network [OSTI]

    Broustis, Ioannis; Syrivelis, Dimitris; Georgiadis, Leonidas; Tassiulas, Leandros

    2011-01-01

    Intersession network coding (NC) can provide significant performance benefits via mixing packets at wireless routers; these benefits are especially pronounced when NC is applied in conjunction with intelligent link scheduling. NC however imposes certain processing operations, such as encoding, decoding, copying and storage. When not utilized carefully, all these operations can induce tremendous processing overheads in practical, wireless, multi-rate settings. Our measurements with prior NC implementations suggest that such processing operations severely degrade the router throughput, especially at high bit rates. Motivated by this, we design {\\bf NCRAWL}, a Network Coding framework for Rate Adaptive Wireless Links. The design of NCRAWL facilitates low overhead NC functionalities, thereby effectively approaching the theoretically expected capacity benefits of joint NC and scheduling. We implement and evaluate NCRAWL on a wireless testbed. Our experiments demonstrate that NCRAWL meets the theoretical predicted ...

  3. Enhanced Jahn-Teller response induced by low-dose 10?MeV I{sup +} irradiation of La{sub 0.7}Ca{sub 0.3}MnO{sub 3??} films

    SciTech Connect (OSTI)

    Harris, V. G., E-mail: v.harris@neu.edu; Chen, Y. [Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts 02115 (United States); Byers, J. M.; Stroud, R. M.; Osofsky, M. S.; Knies, D.; Grabowski, K. S. [U.S. Naval Research Laboratory, Code 6360, Washington, DC 20375 (United States); Browning, V. M.; Fuller-Mora, W. W. [U.S. Naval Research Laboratory, Code 6340, Washington, DC 20375 (United States); Kim, J. [Neocera, LLC, 10000 Virginia Manor Road, Beltsville, Maryland 20705 (United States)

    2014-05-26

    The structural response of pulsed laser deposited La{sub 0.7}Ca{sub 0.3}Mn0{sub 3??} films to low-level 10?MeV I{sup +} irradiation is correlated with magnetic and electronic properties. A series of annealed pulsed laser deposited films were subjected to ion irradiation at doses of 0.5–2.0 × 10{sup 13} 10?MeV iodine ions/cm{sup 2}. X-ray diffraction measurements show no measurable increase in the full width at half maximum values of major reflections before and after irradiation. Extended x-ray absorption fine structure analyses (EXAFS), employing both a model independent fitting using expanded cumulants as well as a nonlinear least squares multiple scattering model based on FEFF generated theoretical EXAFS data, were employed to measure local properties relative to the Mn ions. Increasing irradiation doses lead to an unambiguous evolution of MnO{sub 6} octahedra from highly symmetric (i.e., undistorted) to a clear bimodal structure in which the MnO{sub 6} octahedra are measured to undergo a c-axis stretching bearing resemblance to a Jahn-Teller distortion. Concomitantly, the metal to insulator transition temperature decreases more than 270?K and the magnetoresistance increases from 10{sup 2}% to 10{sup 6}%.

  4. Adaptive characterization of coherent states

    E-Print Network [OSTI]

    Markku P. V. Stenberg; Kevin Pack; Frank K. Wilhelm

    2015-08-18

    We present methods for efficient characterization of an optical coherent state $|\\alpha\\rangle$. We choose measurement settings adaptively and stochastically, based on data while it is collected. Our algorithm divides the estimation in two distinct steps: (i) Before the first detection of vacuum state, the probability of choosing a measurement setting is proportional to detecting vacuum with the setting, which makes using too similar measurement settings twice unlikely and (ii) after the first detection of vacuum, we focus measurements in the region where vacuum is most likely to be detected. In step (i) [(ii)] the detection of vacuum (a photon) has a significantly larger effect on the shape of the posterior probability distribution of $\\alpha$. Compared to nonadaptive schemes, our method makes the number of measurement shots required to achieve certain level of accuracy smaller approximately by a factor proportional to the area describing the initial uncertainty of $\\alpha$ in phase space. While this algorithm is not directly robust against readout errors, we make it such by introducing repeated measurements in the step (i).

  5. Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature

    SciTech Connect (OSTI)

    Yuan, Zhi-Min

    2013-04-28

    Introduction Much of the work addressing ionizing radiation-induced cellular response has been carried out mainly with the traditional cell culture technique involving only one cell type, how cellular response to IR is influenced by the tissue microenvironment remains elusive. By use of a three-dimensional (3D) co-culture system to model critical interactions of different cell types with their neighbors and with their environment, we recently showed that low-dose IR-induced extracellular signaling via the tissue environment affects profoundly cellular responses. This proposal aims at determining the response of mammary epithelial cells in a tissue-like setting.

  6. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression

    SciTech Connect (OSTI)

    Sun, Gui-bo; Sun, Xiao; Wang, Min [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Ye, Jing-xue [Jilin Agricultural University, No.2888, Xincheng Street, Changchun, 130021, Jilin (China)] [Jilin Agricultural University, No.2888, Xincheng Street, Changchun, 130021, Jilin (China); Si, Jian-yong [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Xu, Hui-bo [Academy of Chinese Medical Sciences of Jilin Province, Gongnongda road 1745, Changchun, 130021, Jiblin (China)] [Academy of Chinese Medical Sciences of Jilin Province, Gongnongda road 1745, Changchun, 130021, Jiblin (China); Meng, Xiang-bao; Qin, Meng; Sun, Jing [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China); Wang, Hong-wei, E-mail: hwang@nju.edu.cn [Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093 (China)] [Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093 (China); Sun, Xiao-bo, E-mail: sunsubmit@163.com [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)] [Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 (China)

    2012-12-01

    Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood. To investigate the effects of luteolin on myocardial injury protection and its possible mechanisms, a myocardial injury model was established with intragastric administration of 4 mg/kg isoproterenol (ISO) to male Sprague–Dawley rats (200–220 g) daily for 2 days. We found that pretreatment of luteolin (160, 80 and 40 mg/kg, i.g., respectively) daily for 15 days can prevent ISO-induced myocardial damage, including decrease of serum cardiac enzymes, improvement electrocardiography and heart vacuolation. Luteolin also improved the free radical scavenging and antioxidant potential, suggesting one possible mechanism of luteolin-induced cardio-protection is mediated by blocking the oxidative stress. To clarify the mechanisms, we performed the in vitro study by hydrogen peroxide (H{sub 2}O{sub 2})-induced cytotoxicty model in H9c2 cells. We found that luteolin pretreatment prevented apoptosis, increased the expression of heme oxygenase-1 (HO-1), and enhanced the binding of Nrf2 to the antioxidant response element, providing an adaptive survival response against H{sub 2}O{sub 2}-derived oxidative cytotoxicity. The addition of Znpp, a selective HO-1 competitive inhibitor, reduced the cytoprotective ability of luteolin, indicating the vital role of HO-1 on these effects. Luteolin also activated Akt and ERK, whereas the addition of LY294002 and U0126, the pharmacologic inhibitors of PI3K and ERK, attenuated luteolin-induced HO-1 expression and cytoprotective effect. Taken together, the above findings suggest that luteolin protects against myocardial injury and enhances cellular antioxidant defense capacity through the activation of Akt and ERK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction. -- Highlights: ? Luteolin prevents isoproterenol-induced myocardial damage. ? Luteolin enhances cellular antioxidant defense capacity. ? Luteolin increases the expression of heme oxygenase-1 protein levels. ? Luteolin activates Akt and ERK signal pathways.

  7. Fossil Energy-Developed Fuel Cell Technology Being Adapted by...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fossil Energy-Developed Fuel Cell Technology Being Adapted by Navy for Advanced Unmanned Undersea Vehicles Fossil Energy-Developed Fuel Cell Technology Being Adapted by Navy for...

  8. Anisoplanatism in adaptive optics systems due to pupil aberrations...

    Office of Scientific and Technical Information (OSTI)

    Anisoplanatism in adaptive optics systems due to pupil aberrations Citation Details In-Document Search Title: Anisoplanatism in adaptive optics systems due to pupil aberrations...

  9. Adapting On-Site Electrical Generation Platforms for Producer...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adapting On-Site Electrical Generation Platforms for Producer Gas - Fact Sheet, April 2014 Adapting On-Site Electrical Generation Platforms for Producer Gas - Fact Sheet, April...

  10. Enabling High Efficiency Low Temperature Combustion by Adaptive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Low Temperature Combustion by Adaptive In-Situ Jet Cooling Enabling High Efficiency Low Temperature Combustion by Adaptive In-Situ Jet Cooling A new approach, called...

  11. Kenya-Strengthening Adaptation and Resilience to Climate Change...

    Open Energy Info (EERE)

    Kenya-Strengthening Adaptation and Resilience to Climate Change(StARCK) (Redirected from Strengthening Adaptation and Resilience to Climate Change in Kenya (StARCK)) Jump to:...

  12. India-Vulnerability Assessment and Enhancing Adaptive Capacities...

    Open Energy Info (EERE)

    India-Vulnerability Assessment and Enhancing Adaptive Capacities to Climate Change Jump to: navigation, search Name India-Vulnerability Assessment and Enhancing Adaptive Capacities...

  13. Adaptation to Climate Variability and Change: A Guidance Manual...

    Open Energy Info (EERE)

    Adaptation to Climate Variability and Change: A Guidance Manual for Development Planning Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Adaptation to Climate...

  14. An adaptive mesh refinement technique for dynamics of solids

    E-Print Network [OSTI]

    Trivedi, Abhishek

    2007-01-01

    adaptations; right: cut-off grid with a solution contour.adaptations; right: cut-off grid with a solution contour.

  15. An adaptive sparse-grid-based iterative ensemble Kalman filter...

    Office of Scientific and Technical Information (OSTI)

    An adaptive sparse-grid-based iterative ensemble Kalman filter approach for parameter field estimation Citation Details In-Document Search Title: An adaptive sparse-grid-based...

  16. Financing Climate Adaptation and Mitigation in Rural Areas of...

    Open Energy Info (EERE)

    Financing Climate Adaptation and Mitigation in Rural Areas of Developing Countries Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Financing Climate Adaptation and...

  17. The role of phase instabilities in the early material response...

    Office of Scientific and Technical Information (OSTI)

    The role of phase instabilities in the early material response during laser-induced breakdown in bulk fused silica Citation Details In-Document Search Title: The role of phase...

  18. Advanced Demand Responsive Lighting

    E-Print Network [OSTI]

    Advanced Demand Responsive Lighting Host: Francis Rubinstein Demand Response Research Center demand responsive lighting systems ­ Importance of dimming ­ New wireless controls technologies · Advanced Demand Responsive Lighting (commenced March 2007) #12;Objectives · Provide up-to-date information

  19. Robust adaptive control of switched systems

    E-Print Network [OSTI]

    El-Rifai, Khalid, 1979-

    2007-01-01

    In this thesis, robust adaptive controllers are developed for classes of switched nonlinear systems. Switched systems are those governed by differential equations, which undergo vector field switching due to sudden changes ...

  20. Adaptive control of a generic hypersonic vehicle

    E-Print Network [OSTI]

    Wiese, Daniel Philip

    2013-01-01

    This thesis presents a an adaptive augmented, gain-scheduled baseline LQR-PI controller applied to the Road Runner six-degree-of-freedom generic hypersonic vehicle model. Uncertainty in control effectiveness, longitudinal ...

  1. Adaptive FE Methods for Conservation Equations

    E-Print Network [OSTI]

    Hartmann, Ralf

    Adaptive FE Methods for Conservation Equations Ralf Hartmann Abstract. We present an approach, University of Heidelberg. #12; 2 R. Hartmann by parts on each cell K results in X K2Th h (F (u); rv)K + (F (u

  2. Developmental Plasticity Links Local Adaptation and Evolutionary

    E-Print Network [OSTI]

    Badyaev, Alex

    Developmental Plasticity Links Local Adaptation and Evolutionary Diversification in Foraging, University of Arizona, Tucson, Arizona Developmental plasticity is thought to reconcile the constraining role morphology into adulthood, providing an opportunity to directly examine the links between plasticity of bone

  3. Convert! : the adaptive reuse of churches

    E-Print Network [OSTI]

    Kiley, Christopher John, 1972-

    2004-01-01

    This thesis examines the phenomenon of vacated churches and analyzes the major issues underlying their adaptive reuse in order to help promulgate an awareness of the range of successful strategies and solutions that are ...

  4. Adaptive sampling in autonomous marine sensor networks

    E-Print Network [OSTI]

    Eickstedt, Donald Patrick

    2006-01-01

    In this thesis, an innovative architecture for real-time adaptive and cooperative control of autonomous sensor platforms in a marine sensor network is described in the context of the autonomous oceanographic network scenario. ...

  5. PERSPECTIVE Climate change, adaptation, and phenotypic plasticity

    E-Print Network [OSTI]

    Hendry, Andrew

    PERSPECTIVE Climate change, adaptation, and phenotypic plasticity: the problem and the evidence plasticity, natural selection Correspondence Juha Merila, Ecological Genetics Research Unit, Department distinguish whether phenotypic changes are genetically based or the result of phenotypic plasticity. Second

  6. Collaborative Adaptive Science for Self Reliance

    E-Print Network [OSTI]

    Tate, Kenneth

    (Koyukuk) · Clean water (Iguigig) · Salmon fishing (Nikolai) Shared Issues: · High cost of energy other #12;· Historically adaptive. · Confluence of increased gas and food prices, reduction in state ­ Potential improvements ­ Benefits of experience ­ Improve self reliance? ­ Future partnerships ­ Other

  7. ADAPTIVE DISCRETIZATION OF AN INTEGRODIFFERENTIAL EQUATION

    E-Print Network [OSTI]

    Larsson, Stig

    ADAPTIVE DISCRETIZATION OF AN INTEGRO­DIFFERENTIAL EQUATION MODELING QUASI­STATIC FRACTIONAL ORDER VISCOELASTICITY Klas Adolfsson # Mikael Enelund ## Stig Larsson ### # Department of Applied Mechanics, Chalmers Mechanics, Chalmers University of Technology, SE--412 96 GË?oteborg, Sweden, mikael

  8. Adaptive Java Optimisation using machine learning techniques 

    E-Print Network [OSTI]

    Long, Shun

    approach are implemented in a prototype Adaptive Optimisation Framework for Java (AOF-Java). The experimental results show that the heuristic random search algorithm can find, within a relatively small number of atttempts, good points in the large...

  9. Adaptive Grids for Atmospheric General Circulation Models

    E-Print Network [OSTI]

    Jablonowski, Christiane

    the wind speed OMEGA model Courtesy of A. Sarma (SAIC, NC, USA) #12;Two Adaptive Shallow Water Models AMR the vertical resolutions adds another factor of 2 We need to increase our computational power by a factor

  10. Climate Change: High Water Impacts and Adaptation

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Climate Change: High Water Impacts and Adaptation David S. Liebl and Kenneth W. Potter Co of global climate change­ WICCI Stormwater Working Group #12;Projected Climate Change 200-2100 What Global

  11. Scalable Adaptive Multilevel Solvers for Multiphysics Problems

    SciTech Connect (OSTI)

    Xu, Jinchao

    2014-12-01

    In this project, we investigated adaptive, parallel, and multilevel methods for numerical modeling of various real-world applications, including Magnetohydrodynamics (MHD), complex fluids, Electromagnetism, Navier-Stokes equations, and reservoir simulation. First, we have designed improved mathematical models and numerical discretizaitons for viscoelastic fluids and MHD. Second, we have derived new a posteriori error estimators and extended the applicability of adaptivity to various problems. Third, we have developed multilevel solvers for solving scalar partial differential equations (PDEs) as well as coupled systems of PDEs, especially on unstructured grids. Moreover, we have integrated the study between adaptive method and multilevel methods, and made significant efforts and advances in adaptive multilevel methods of the multi-physics problems.

  12. Adaptive Basis Sampling for Smoothing Splines 

    E-Print Network [OSTI]

    Zhang, Nan

    2015-08-03

    . However, the high computational cost of smoothing splines for large data sets has hindered their wide application. We develop a new method, named adaptive basis sampling, for efficient computation of smoothing splines in super-large samples. Generally, a...

  13. Human adaptation of avian influenza viruses

    E-Print Network [OSTI]

    Srinivasan, Karunya

    2012-01-01

    Human adaptation of avian influenza viruses pose an enormous public health challenge as the human population is predominantly naive to avian influenza antigens. As such, constant surveillance is needed to monitor the ...

  14. 7th International Workshop on Microbeam Probes of Cellular Radiation Response

    SciTech Connect (OSTI)

    Brenner, David J.

    2009-07-21

    The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia University’s Kellogg Center in New York City on March 15–17, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (1–5). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and ‘‘non-targeted’’ responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

  15. The Durham ELT adaptive optics simulation platform

    E-Print Network [OSTI]

    Alastair Basden; Timothy Butterley; Richard Myers; Richard Wilson

    2006-11-09

    Adaptive optics systems are essential on all large telescopes where image quality is important. These are complex systems with many design parameters requiring optimisation before good performance can be achieved. The simulation of adaptive optics systems is therefore necessary to categorise the expected performance. This paper describes an adaptive optics simulation platform, developed at Durham University, which can be used to simulate adaptive optics systems on the largest proposed future extremely large telescopes (ELTs) as well as current systems. This platform is modular, object oriented and has the benefit of hardware application acceleration which can be used to improve the simulation performance, essential for ensuring that the run time of a given simulation is acceptable. The simulation platform described here can be highly parallelised using parallelisation techniques suited for adaptive optics simulation, whilst still offering the user complete control while the simulation is running. Results from the simulation of a ground layer adaptive optics system are provided as an example to demonstrate the flexibility of this simulation platform.

  16. Mechanisms of AH receptor-mediated responses 

    E-Print Network [OSTI]

    Dong, Lian

    1996-01-01

    The interaction of the nuclear aryl hydrocarbon (Ah) receptor complex with c-fos and c-jun oncoprotein was investigated in wild-type Ah responsive mouse Hepa lclc7 cells. Chloramphenicol acetyl transferase (CAT) activity was induced by 10 riM 2...

  17. Adaptation to water scarcity in glacier-dependent towns of the Indian Himalayas : impacts, adaptive responses, barriers, and solutions

    E-Print Network [OSTI]

    Sudhalkar, Amruta Anand

    2010-01-01

    Among the existing and projected impacts of climate change, impacts on water resources are expected to exacerbate the current and future threat of global water scarcity. Glacier-dependent societies are especially vulnerable ...

  18. Hepatocyte Responses to In Vitro Freezing and b-Adrenergic

    E-Print Network [OSTI]

    Lee Jr., Richard E.

    Hepatocyte Responses to In Vitro Freezing and b-Adrenergic Stimulation: Insights into the Extreme Freeze Tolerance of Subarctic Rana sylvatica M. CLARA F. DO AMARAL*, RICHARD E. LEE JR., AND JON P, is one of several amphibians known to tolerate corporal freezing as an adaptation to survive winter

  19. Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

    E-Print Network [OSTI]

    Morimoto, Richard

    Characterizing the Altered Cellular Proteome Induced by the Stress- Independent Activation of Heat activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces-responsive signaling pathways such as the heat shock response (HSR).1,2 The HSR is an evolutionarily conserved, stress

  20. Cell, Vol. 90, 4353, July 11, 1997, Copyright 1997 by Cell Press A Small, Stable RNA Induced by Oxidative

    E-Print Network [OSTI]

    Mekalanos, John

    suggest that the oxyS RNA acts as a regulator thatintegrates adaptation to hydro- A Small RNA InducedCell, Vol. 90, 43­53, July 11, 1997, Copyright ©1997 by Cell Press A Small, Stable RNA Induced-Fischer, While unique functions have been discovered for a subset of the small RNA population, the roles of other

  1. The Sponge Pump: The Role of Current Induced Flow in the Design of the Sponge Body Plan

    E-Print Network [OSTI]

    Yahel, Gitai

    The Sponge Pump: The Role of Current Induced Flow in the Design of the Sponge Body Plan Sally P filtration have estimated the energetic cost of pumping to be ,1% of its total metabolism implying there is little adaptive value to reducing the cost of pumping by using ``passive'' flow induced by the ambient

  2. Chromatic Light Adaptation Measured using Functional Magnetic Resonance Imaging

    E-Print Network [OSTI]

    Wandell, Brian A.

    Chromatic Light Adaptation Measured using Functional Magnetic Resonance Imaging Alex R. Wade- nisms within cone photoreceptor classes. Key words: fMRI; light adaptation; cones; simulation; V1; Naka regulation is part of a process called light adaptation. Light adaptation is an important computational step

  3. Data Modelling for Analysis of Adaptive Changes in Fly Photoreceptors

    E-Print Network [OSTI]

    Juusola, Mikko

    describe accurately the observed adaptation process at each new level of changing light inputs. GeneralizedData Modelling for Analysis of Adaptive Changes in Fly Photoreceptors Uwe Friederich1,2 , Daniel://www.shef.ac.uk/acse Abstract. Adaptation is a hallmark of sensory processing. We studied neural adaptation in intracellular

  4. Adaptively Secure Coin-Flipping, Revisited Shafi Goldwasser1

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    in this setting. We then shed light on the connection between adaptive and strongly adaptive adversariesAdaptively Secure Coin-Flipping, Revisited Shafi Goldwasser1 , Yael Tauman Kalai2 , and Sunoo Park3' bits, can tolerate t(n) = O( n) even in the presence of adaptive corruptions, and they conjectured

  5. Skeletal Adaptations in Humans How are we anatomically different?

    E-Print Network [OSTI]

    posteriorly #12;Skeletal Adaptations in Humans · Vertebral Column ­ lumbar + cervical curvatures ­ more

  6. Adaptation strategies for health impacts of climate change in Western Australia: Application of a Health Impact Assessment framework

    SciTech Connect (OSTI)

    Spickett, Jeffery T.; Brown, Helen L.; Katscherian, Dianne

    2011-04-15

    Climate change is one of the greatest challenges facing the globe and there is substantial evidence that this will result in a number of health impacts, regardless of the level of greenhouse gas mitigation. It is therefore apparent that a combined approach of mitigation and adaptation will be required to protect public health. While the importance of mitigation is recognised, this project focused on the role of adaptation strategies in addressing the potential health impacts of climate change. The nature and magnitude of these health impacts will be determined by a number of parameters that are dependent upon the location. Firstly, climate change will vary between regions. Secondly, the characteristics of each region in terms of population and the ability to adapt to changes will greatly influence the extent of the health impacts that are experienced now and into the future. Effective adaptation measures therefore need to be developed with these differences in mind. A Health Impact Assessment (HIA) framework was used to consider the implications of climate change on the health of the population of Western Australia (WA) and to develop a range of adaptive responses suited to WA. A broad range of stakeholders participated in the HIA process, providing informed input into developing an understanding of the potential health impacts and potential adaptation strategies from a diverse sector perspective. Potential health impacts were identified in relation to climate change predictions in WA in the year 2030. The risk associated with each of these impacts was assessed using a qualitative process that considered the consequences and the likelihood of the health impact occurring. Adaptations were then developed which could be used to mitigate the identified health impacts and provide responses which could be used by Government for future decision making. The periodic application of a HIA framework is seen as an ideal tool to develop appropriate adaptation strategies to address the potential health impacts of climate change.

  7. Adaptive Plasticity and Plasticity as an Adaptation: A Selective Review of Plasticity in Animal Morphology and Life History

    E-Print Network [OSTI]

    Gotthard, Karl

    Adaptive Plasticity and Plasticity as an Adaptation: A Selective Review of Plasticity in Animal wide-ranging. All key REVIEW references should be cited. A summary is required. Adaptive plasticity and plasticity as an adaptation: a selective review of plasticity in animal morphology and life history Karl

  8. Experimental investigation and constitutive modeling of the large deformation behavior of anisotropic steel sheets undergoing strain-induced phase transformation

    E-Print Network [OSTI]

    Beese, Allison M

    2011-01-01

    The strain-induced phase transformation from austenite to martensite is responsible for the high strength and ductility of TRansformation-Induced Plasticity (TRIP)- assisted steels. The large deformation behavior of ...

  9. DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2009-01-01

    Kastan, M. B. (1997). DNA damage induces phosphorylation ofby ATM in response to DNA damage. Science 281, Barber, R. ,Nussenzweig, A. (2002). DNA damage-induced G2-M checkpoint

  10. Adaptive and Non-Adaptive Distribution Functions for DSA Melanie Smith

    E-Print Network [OSTI]

    Mailler, Roger

    Adaptive and Non-Adaptive Distribution Functions for DSA Melanie Smith University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104 melanie@utulsa.edu Sandip Sen University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104 sandip-sen@utulsa.edu Roger Mailler University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104

  11. EOLSS ADAPTATIONS TO LIFE IN MARINE CAVES PAGE 1 ADAPTATIONS TO LIFE IN MARINE CAVES

    E-Print Network [OSTI]

    Iliffe, Thomas M.

    EOLSS ­ ADAPTATIONS TO LIFE IN MARINE CAVES PAGE 1 ADAPTATIONS TO LIFE IN MARINE CAVES Thomas M. Iliffe, Department of Marine Biology, Texas A&M University at Galveston, USA Renée E. Bishop, Department of caves will result in their extinction. 1. Introduction 1.1 Definition of anchialine and marine caves

  12. Current Biology 18, 15761580, October 28, 2008 2008 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2008.08.068 fMRI Adaptation Reveals Mirror Neurons

    E-Print Network [OSTI]

    Kanwisher, Nancy

    .1016/j.cub.2008.08.068 Report fMRI Adaptation Reveals Mirror Neurons in Human Inferior Parietal CortexMRI adaptation to show that the right inferior parietal lobe (IPL) responds indepen- dently to specific actions regardless of whether they are observed or executed. Specifically, responses in the right IPL were attenuated

  13. Urban Studies, Vol. 40, No. 7, 000000, 2003 Induced Demand: A Microscopic Perspective

    E-Print Network [OSTI]

    Levinson, David M.

    . Introduction Transport forecasts often assume limited or no response of demand to changes in supply of the response of demand to supply, also referred to as induced or latent demand. According to the induced demand demand hypoth- esis to date has mostly been carried out at the aggregate level, considering state, metro

  14. Natural Disasters and Adaptation to Climate Change Edited by Sarah Boulter, Jean Palutikof, David Karoly, and Daniela Guitart

    E-Print Network [OSTI]

    Batterbury, Simon

    wave: impacts, public health adaptation and response in France 189 Mathilde Pascal, Alain Le Tertre cyclone Sidr in Bangladesh 264 Bimal K. Paul and Munshi K. Rahman 18 Coffee, disasters, and social-ecological resilience in Guatemala and Chiapas, Mexico 276 Hallie Eakin, Helda Morales, Edwin Castellanos, Gustavo Cruz

  15. Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats

    SciTech Connect (OSTI)

    Liu, Tao, E-mail: liutaomedical@qq.com [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China)] [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Meng, Qiang, E-mail: mengq531@yahoo.cn [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China) [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University (China); Wang, Changyuan, E-mail: wangcyuan@163.com [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China) [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University (China); Liu, Qi, E-mail: llaqii@yahoo.com.cn [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China) [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University (China); Guo, Xinjin, E-mail: guo.xinjin@163.com [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China)] [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Sun, Huijun, E-mail: sunhuijun@hotmail.com [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China) [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University (China); Peng, Jinyong, E-mail: jinyongpeng2005@163.com [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China) [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 9 West Section, Lvshun South Road, Lvshunkou District, Dalian 116044 (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University (China); and others

    2012-11-01

    The purpose of this study is to investigate whether the effect of cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485) on acute renal failure (ARF) induced by cisplatin is related to change in expression of renal Oat1, Oat3 and Mrp2 in rats. JBP485 reduced creatinine, blood urea nitrogen (BUN) and indoxyl sulfate (IS) in plasma and malondialdehyde (MDA) in kidney, and recovered the glomerular filtration rate (GFR) and the activity of superoxide dismutase (SOD) in cisplatin-treated rats. The plasma concentration of PAH (para-aminohippurate) determined by LC–MS/MS was increased markedly after intravenous administration of cisplatin, whereas cumulative urinary excretion of PAH and the uptake of PAH in kidney slices were significantly decreased. qRT-PCR and Western-blot showed a decrease in mRNA and protein of Oat1 and Oat3, an increase in mRNA and protein of Mrp2 in cisplatin-treated rats, and an increase in IS (a uremic toxin) after co-treatment with JBP485. It indicated that JBP485 promoted urinary excretion of toxins by upregulating renal Mrp2. This therefore gives in part the explanation about the mechanism by which JBP485 improves ARF induced by cisplatin in rats. -- Highlights: ? Cisplatin induces acute renal failure (ARF). ? The expression of Oat1, Oat3 and Mrp2 were changed during ARF. ? The regulated expression of Oat1, Oat3 and Mrp2 is an adaptive protected response. ? JBP485 could facilitate the adaptive protective action.

  16. Vulnerability and adaptation to severe weather events in the American southwest

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Boero, Riccardo; Bianchini, Laura; Pasqualini, Donatella

    2015-05-04

    Climate change can induce changes in the frequency of severe weather events representing a threat to socio-economic development. It is thus of uttermost importance to understand how the vulnerability to the weather of local communities is determined and how adaptation public policies can be effectively put in place. We focused our empirical analysis on the American Southwest. Results show that, consistently with the predictions of an investment model, economic characteristics signaling local economic growth in the near future decrease the level of vulnerability. We also show that federal governments transfers and grants neither work to support recovery from and adaptationmore »to weather events nor to distribute their costs over a broader tax base. Finally, we show that communities relying on municipal bonds to finance adaptation and recovery policies can benefit from local acknowledgment of the need for such policies and that they do not have to pay lenders a premium for the risk induced by weather events. In conclusion, our findings suggest that determinants of economic growth support lower vulnerability to the weather and increase options for financing adaptation and recovery policies, but also that only some communities are likely to benefit from those processes.« less

  17. The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry

    SciTech Connect (OSTI)

    de Wit, Pierre J. G. M.; van der Burgt, Ate; Okmen, Bilal; Stergiopoulos, Ioannis; Abd-Elsalam, Kamel A.; Aerts, Andrea L.; Bahkali, Ali H.; Beenen, Henriek G.; Chettri, Oranav; Cos, Murray P.; Datema, Erwin; de Vries, Ronald P.; DHillon, Braham; Ganley, Austen R.; Griffiths, Scott A.; Guo, Yanan; Gamelin, Richard C.; Henrissat, Bernard; Kabir, M. Shahjahan; Jashni, Mansoor Karimi; Kema, Gert; Klaubauf, Sylvia; Lapidus, Alla; Levasseur, Anthony; Lindquist, Erika; Mehrabi, Rahim; Ohm, Robin A.; Owen, Timothy J.; Salamov, Asaf; Schwelm, Arne; Schijlen, Elio; Sun, Hui; van den Burg, Harrold A.; van Burg, Roeland C. H. J.; Zhang, Shuguang; Goodwin, Stephen B.; Grigoriev, Igor V.; Collemare, Jerome; Bradshaw, Rosie E.

    2012-05-04

    We sequenced and compared the genomes of the Dothideomycete fungal plant pathogens Cladosporium fulvum (Cfu) (syn. Passalora fulva) and Dothistroma septosporum (Dse) that are closely related phylogenetically, but have different lifestyles and hosts. Although both fungi grow extracellularly in close contact with host mesophyll cells, Cfu is a biotroph infecting tomato, while Dse is a hemibiotroph infecting pine. The genomes of these fungi have a similar set of genes (70percent of gene content in both genomes are homologs), but differ significantly in size (Cfu >61.1-Mb; Dse 31.2-Mb), which is mainly due to the difference in repeat content (47.2percent in Cfu versus 3.2percent in Dse). Recent adaptation to different lifestyles and hosts is suggested by diverged sets of genes. Cfu contains an tomatinase gene that we predict might be required for detoxification of tomatine, while this gene is absent in Dse. Many genes encoding secreted proteins are unique to each species and the repeat-rich areas in Cfu are enriched for these species-specific genes. In contrast, conserved genes suggest common host ancestry. Homologs of Cfu effector genes, including Ecp2 and Avr4, are present in Dse and induce a Cf-Ecp2- and Cf-4-mediated hypersensitive response, respectively. Strikingly, genes involved in production of the toxin dothistromin, a likely virulence factor for Dse, are conserved in Cfu, but their expression differs markedly with essentially no expression by Cfu in planta. Likewise, Cfu has a carbohydrate-degrading enzyme catalog that is more similar to that of necrotrophs or hemibiotrophs and a larger pectinolytic gene arsenal than Dse, but many of these genes are not expressed in planta or are pseudogenized. Overall, comparison of their genomes suggests that these closely related plant pathogens had a common ancestral host but since adapted to different hosts and lifestyles by a combination of differentiated gene content, pseudogenization, and gene regulation.

  18. A hypoxia-inducible factor (HIF)-3? splicing variant, HIF-3?4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3?4

    SciTech Connect (OSTI)

    Ando, Hitoshi [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan) [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan); Department of Neurosurgery, Fukushima Medical University School of Medicine, Fukushima (Japan); Natsume, Atsushi, E-mail: anatsume@med.nagoya-u.ac.jp [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan)] [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan); Iwami, Kenichiro; Ohka, Fumiharu [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan)] [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan); Kuchimaru, Takahiro; Kizaka-Kondoh, Shinae [Department of Biomolecular Engineering, Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Yokohama (Japan)] [Department of Biomolecular Engineering, Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Yokohama (Japan); Ito, Kengo [National Center for Geriatrics and Gerontology, Aichi (Japan)] [National Center for Geriatrics and Gerontology, Aichi (Japan); Saito, Kiyoshi [Department of Neurosurgery, Fukushima Medical University School of Medicine, Fukushima (Japan)] [Department of Neurosurgery, Fukushima Medical University School of Medicine, Fukushima (Japan); Sugita, Sachi; Hoshino, Tsuneyoshi [MICRON Inc.Medical Facilities Support Department, Aichi (Japan)] [MICRON Inc.Medical Facilities Support Department, Aichi (Japan); Wakabayashi, Toshihiko [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan)] [Department of Neurosurgery, Nagoya University School of Medicine, Nagoya (Japan)

    2013-03-29

    Highlights: ? HIF-3?4 is silenced by DNA methylation in meningiomas. ? Induction of HIF-3?4 impaired angiogenesis in meningiomas. ? Induction of HIF-3?4 impaired proliferation and oxygen-dependent metabolism. -- Abstract: Hypoxia inducible factor is a dominant regulator of adaptive cellular responses to hypoxia and controls the expression of a large number of genes regulating angiogenesis as well as metabolism, cell survival, apoptosis, and other cellular functions in an oxygen level-dependent manner. When a neoplasm is able to induce angiogenesis, tumor progression occurs more rapidly because of the nutrients provided by the neovasculature. Meningioma is one of the most hypervascular brain tumors, making anti-angiogenic therapy an attractive novel therapy for these tumors. HIF-3? has been conventionally regarded as a dominant-negative regulator of HIF-1?, and although alternative HIF-3? splicing variants are extensively reported, their specific functions have not yet been determined. In this study, we found that the transcription of HIF-3?4 was silenced by the promoter DNA methylation in meningiomas, and inducible HIF-3?4 impaired angiogenesis, proliferation, and metabolism/oxidation in hypervascular meningiomas. Thus, HIF-3?4 could be a potential molecular target in meningiomas.

  19. Load attenuating passively adaptive wind turbine blade

    DOE Patents [OSTI]

    Veers, Paul S.; Lobitz, Donald W.

    2003-01-07

    A method and apparatus for improving wind turbine performance by alleviating loads and controlling the rotor. The invention employs the use of a passively adaptive blade that senses the wind velocity or rotational speed, and accordingly modifies its aerodynamic configuration. The invention exploits the load mitigation prospects of a blade that twists toward feather as it bends. The invention includes passively adaptive wind turbine rotors or blades with currently preferred power control features. The apparatus is a composite fiber horizontal axis wind-turbine blade, in which a substantial majority of fibers in the blade skin are inclined at angles of between 15 and 30 degrees to the axis of the blade, to produces passive adaptive aeroelastic tailoring (bend-twist coupling) to alleviate loading without unduly jeopardizing performance.

  20. Load attenuating passively adaptive wind turbine blade

    DOE Patents [OSTI]

    Veers, Paul S. (Albuquerque, NM); Lobitz, Donald W. (Albuquerque, NM)

    2003-01-01

    A method and apparatus for improving wind turbine performance by alleviating loads and controlling the rotor. The invention employs the use of a passively adaptive blade that senses the wind velocity or rotational speed, and accordingly modifies its aerodynamic configuration. The invention exploits the load mitigation prospects of a blade that twists toward feather as it bends. The invention includes passively adaptive wind turbine rotors or blades with currently preferred power control features. The apparatus is a composite fiber horizontal axis wind-turbine blade, in which a substantial majority of fibers in the blade skin are inclined at angles of between 15 and 30 degrees to the axis of the blade, to produces passive adaptive aeroelastic tailoring (bend-twist coupling) to alleviate loading without unduly jeopardizing performance.

  1. A phased approach to induced seismicity risk management

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    White, Joshua A.; Foxall, William

    2014-01-01

    This work describes strategies for assessing and managing induced seismicity risk during each phase of a carbon storage project. We consider both nuisance and damage potential from induced earthquakes, as well as the indirect risk of enhancing fault leakage pathways. A phased approach to seismicity management is proposed, in which operations are continuously adapted based on available information and an on-going estimate of risk. At each project stage, specific recommendations are made for (a) monitoring and characterization, (b) modeling and analysis, and (c) site operations. The resulting methodology can help lower seismic risk while ensuring site operations remain practical andmore »cost-effective.« less

  2. A phased approach to induced seismicity risk management

    SciTech Connect (OSTI)

    White, Joshua A.; Foxall, William

    2014-01-01

    This work describes strategies for assessing and managing induced seismicity risk during each phase of a carbon storage project. We consider both nuisance and damage potential from induced earthquakes, as well as the indirect risk of enhancing fault leakage pathways. A phased approach to seismicity management is proposed, in which operations are continuously adapted based on available information and an on-going estimate of risk. At each project stage, specific recommendations are made for (a) monitoring and characterization, (b) modeling and analysis, and (c) site operations. The resulting methodology can help lower seismic risk while ensuring site operations remain practical and cost-effective.

  3. Cavitation-resistant inducer

    DOE Patents [OSTI]

    Dunn, Charlton (Calabasas, CA); Subbaraman, Maria R. (Canoga Park, CA)

    1989-01-01

    An improvement in an inducer for a pump wherein the inducer includes a hub, a plurality of radially extending substantially helical blades and a wall member extending about and encompassing an outer periphery of the blades. The improvement comprises forming adjacent pairs of blades and the hub to provide a substantially rectangular cross-sectional flow area which cross-sectional flow area decreases from the inlet end of the inducer to a discharge end of the inducer, resulting in increased inducer efficiency improved suction performance, reduced susceptibility to cavitation, reduced susceptibility to hub separation and reduced fabrication costs.

  4. Cavitation-resistant inducer

    DOE Patents [OSTI]

    Dunn, C.; Subbaraman, M.R.

    1989-06-13

    An improvement in an inducer for a pump is disclosed wherein the inducer includes a hub, a plurality of radially extending substantially helical blades and a wall member extending about and encompassing an outer periphery of the blades. The improvement comprises forming adjacent pairs of blades and the hub to provide a substantially rectangular cross-sectional flow area which cross-sectional flow area decreases from the inlet end of the inducer to a discharge end of the inducer, resulting in increased inducer efficiency improved suction performance, reduced susceptibility to cavitation, reduced susceptibility to hub separation and reduced fabrication costs. 11 figs.

  5. Response of continuous pipelines to tunnel induced ground deformations

    E-Print Network [OSTI]

    Ieronymaki, Evangelia S

    2011-01-01

    This thesis develops analytical solutions for estimating the bending moments and axial loads in a buried pipeline due to ground movements caused by tunnel construction in soft ground. The solutions combine closed-form, ...

  6. Induced Responses to Herbivory and Jasmonate in Three Milkweed Species

    E-Print Network [OSTI]

    Agrawal, Anurag

    if each compound was ingested separately. It is thought that plasticity in the deployment of plant serves as a physical barrier and a source of concentrated toxins effective again

  7. Shifting gears: Thermodynamics of genetic information storage suggest stress-dependence of mutation rate, which can accelerate adaptation

    E-Print Network [OSTI]

    Hilbert, Lennart

    2011-01-01

    Background: Acceleration of adaptation dynamics by stress-induced hypermutation has been found experimentally. Evolved evolvability is a prominent explanation. We investigate a more generally applicable explanation by a physical constraint. Methods and Results: A generic thermodynamical analysis of genetic information storage obviates physical constraints on the integrity of genetic information. The capability to employ metabolic resources is found as a major determinant of mutation probability in stored genetic information. Incorporation into a non-recombinant, asexual adaptation toy model predicts cases of markedly accelerated adaptation, driven by a transient increase of mutation rate. No change in the mutation rate as a genetic trait is required. The mutation rate of one and the same genotype varies dependent on stress level. Implications: Stress-dependent mutation rates are physically necessary and challenge a condition-independent genotype to mutation rate mapping. This holds implications for evolutiona...

  8. ADAPTIKs: Adaptive Information Keyholes for Public Libraries

    E-Print Network [OSTI]

    Deussen, Oliver

    public sphere. In particular in terms of demographic aspects, public libraries need to provide). ADAPTIKs is intended to serve two purposes: first, as an information service that extends the libraryADAPTIKs: Adaptive Information Keyholes for Public Libraries Jens M¨uller HCI Group University

  9. ADAPTIVE POWER CAPPING FOR SERVERS WITH

    E-Print Network [OSTI]

    Coskun, Ayse

    ................................................................................................................................................................................................................... POWER CAPPING IN COMPUTER CLUSTERS ENABLES ENERGY BUDGETING, EFFICIENT POWER DELIVERY, AND MANAGEMENT CHARACTERISTICS AND ADAPTING TO DYNAMIC-POWER CAPS. PACK AND CAP IMPROVES ENERGY EFFICIENCY AND ACHIEVABLE RANGE as much as 400 percent in the past decade.1 Modern data-center energy consumption results in millions

  10. An Infrastructure for Adaptive Dynamic Optimization

    E-Print Network [OSTI]

    Amarasinghe, Saman

    An Infrastructure for Adaptive Dynamic Optimization Derek Bruening, Timothy Garnett, and Saman,timothyg,saman}@lcs.mit.edu Abstract Dynamic optimization is emerging as a promising ap- proach to overcome many of the obstacles static optimizations, there are very few for developing dynamic optimizations. We present a framework

  11. Adaptive immunity in invertebrates: a straw house

    E-Print Network [OSTI]

    Little, Tom

    Adaptive immunity in invertebrates: a straw house without a mechanistic foundation Chris Hauton1 by descriptions of the underlying mechanisms. We caution against a reliance on this approach as a means limitations and highlight the fundamental necessity for rigorous mechanistic data. Innate `priming' or `memory

  12. Phenotypic Plasticity: Molecular Mechanisms and Adaptive Significance

    E-Print Network [OSTI]

    Saltzman, Wendy

    Phenotypic Plasticity: Molecular Mechanisms and Adaptive Significance Scott A. Kelly,*1,2 Tami M. Panhuis,2 and Andrew M. Stoehr3 ABSTRACT Phenotypic plasticity can be broadly defined as the ability organization. From an ecological and evolutionary perspective, phenotypic plasticity may be a powerful means

  13. Autonomous Organization-Based Adaptive Information Systems

    E-Print Network [OSTI]

    Deloach, Scott A.

    Autonomous Organization-Based Adaptive Information Systems Eric Matson Department of ComputerLoach Multi-agent and Cooperative Robotics Lab Department of Computing and Information Sciences, Kansas State of battle, a continual flow of information is necessary to achieve information superiority. The required

  14. ADAPTIKs: Adaptive Information Keyholes for Public Libraries

    E-Print Network [OSTI]

    Deussen, Oliver

    critical thresholds ([7], [4]). Addressing their impact on public awareness and social acceptance, Brignull the visitors' position and body movements can be used to generate an adaptive silhouette that acts as a keyhole libraries, however, represent physical and social places for encounter. In addition, as a comprehensive

  15. Designing Adaptive Trading Agents DAVID PARDOE

    E-Print Network [OSTI]

    Stone, Peter

    should make use of this experience. Within the context of a specific market scenario, the answer depends to the first three questions depend on the particular market scenario being considered, and our work spansDesigning Adaptive Trading Agents DAVID PARDOE Yahoo! Labs and PETER STONE The University of Texas

  16. Accurate Direct Illumination Using Iterative Adaptive Sampling

    E-Print Network [OSTI]

    Bala, Kavita

    Accurate Direct Illumination Using Iterative Adaptive Sampling Michael Donikian, Bruce Walter with many lights and complex occlusion. Images are first divided into 8 Â 8 pixel blocks and for each point to be shaded within a block, a probability density function (PDF) is constructed over the lights and sampled

  17. Adaptive Background Estimation using Intensity Independent Features

    E-Print Network [OSTI]

    Lunds Universitet

    Adaptive Background Estimation using Intensity Independent Features Håkan Ardö, Rikard Berthilsson to rapid changes in lighting conditions. Furthermore, the features can be computed very efficiently using reliable way, also in outdoor scenes where the lighting conditions is changing rapidly due to passing

  18. Simple Adaptive Strategies: From Regret Matching

    E-Print Network [OSTI]

    Hart, Sergiu

    Simple Adaptive Strategies: From Regret Matching to Uncoupled Dynamics Sergiu Hart Andreu Mas, computers--even genes. See the Hand- book of Game Theory (Aumann and Hart 1994, 2002, 2004; Young and Zamir, Israel. E-mail: hart@huji.ac.il; URL: http://www.ma.huji.ac.il/hart. Department of Economics

  19. Robot Behavior Adaptation for Formation Maintenance

    E-Print Network [OSTI]

    López-Sánchez, Maite

    1 Robot Behavior Adaptation for Formation Maintenance Maite López-Sánchez maite@maia.ub.es WAI): ­1 or 2 reference robots to follow ­keeping fixed angle (formation property) ­and fixed distance d (separation distance) · related to robot visibility range, speed or reaction capabilities Basic behaviors I

  20. Solving Nonlinear Equations by Adaptive Homotopy Continuation*

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    ,fornia 90089 and L. Tesfatsion+ Department of Economics and Department of Mathematics lowa State University to complex values and adaptively computing a continuation path in the complex plane that avoids points giving. Numerical examples are presented which indicate the effectiveness of the approach. *This work was partially

  1. Energy-Aware Adaptive Network Resource Management

    E-Print Network [OSTI]

    Haddadi, Hamed

    Energy-Aware Adaptive Network Resource Management M. Charalambides, D. Tuncer, L. Mamatas, G protocols, this can lead to periods of resource under- utilization and constant energy consumption solutions are still missing. Existing approaches in the literature that address energy efficiency in network

  2. Adaptive Training for Large Vocabulary Continuous

    E-Print Network [OSTI]

    Hain, Thomas

    Adaptive Training for Large Vocabulary Continuous Speech Recognition Kai Yu Hughes Hall College for the degree of Doctor of Philosophy #12;ii Summary In recent years, there has been a trend towards training is to train hidden Markov models (HMMs) on the whole data set as if all data comes from a single acoustic

  3. Adaptive Fuzzy Systems for Multichannel Signal Processing

    E-Print Network [OSTI]

    Plataniotis, Konstantinos N.

    Adaptive Fuzzy Systems for Multichannel Signal Processing KONSTANTINOS N. PLATANIOTIS, MEMBER, IEEE Processing multichannel signals using digital signal process- ing techniques has received increased attention beginning in this area and 2) to provide a review for the reader who may be well versed in signal processing

  4. Mitigation and Adaptation Strategies for Global Change

    E-Print Network [OSTI]

    concerns about rising energy demand and cost, diminishing oil reserves, and climate change, Central a critical analysis of this experience focusing on non-technical barriers to investment. Survey results America . Caribbean basin initiative . Trade and investment . Energy security Mitig Adapt Strateg Glob

  5. Reservation Price Estimation by Adaptive Conjoint Analysis

    E-Print Network [OSTI]

    Schmidt-Thieme, Lars

    Reservation Price Estimation by Adaptive Conjoint Analysis Christoph Breidert1 , Michael Hahsler1 applied the eco- nomic definition of reservation price in combination with a conjoint study on product pricing. In this paper we present a novel approach to estimate the economic reser- vation price using

  6. Shape-Adaptive Ultra-Lightweight

    E-Print Network [OSTI]

    of a concentrating solar power system. Traditional solar concentrators have no corrective capabilities to compensateShape-Adaptive Ultra-Lightweight Solar Concentrators Solar concentrators are key components the aberrations due to external disturbances during installation and operation, preventing the solar power system

  7. Genetic Painting: A Salience Adaptive Relaxation Technique

    E-Print Network [OSTI]

    Collomosse, John

    Chapter 4 Genetic Painting: A Salience Adaptive Relaxation Technique for Painterly Rendering paintings1. We draw upon our previous ob- servations of artistic practice to define the degree of optimality for a painting to be measured by the correlation between the salience map of the original image and the level

  8. Adaptive cache decay Paolo Bennati, Roberto Giorgi

    E-Print Network [OSTI]

    Giorgi, Roberto

    to save power. Our idea is to adaptively select mostly used cache lines. We found that this can MiBench suite for ARM based processor, show 13% improvement in leakage saving and 21% in EDP versus drowsy cache and 52% improvement in leakage saving and 65% in EDP versus cache decay (in average

  9. Semantic Web Technologies for the Adaptive Web

    E-Print Network [OSTI]

    Nejdl, Wolfgang

    23 Semantic Web Technologies for the Adaptive Web Peter Dolog1 and Wolfgang Nejdl2 1 Department.de Abstract. Ontologies and reasoning are the key terms brought into focus by the semantic web community. Formal representation of ontologies in a common data model on the web can be taken as a foundation

  10. Adaptive, full-spectrum solar energy system

    DOE Patents [OSTI]

    Muhs, Jeffrey D.; Earl, Dennis D.

    2003-08-05

    An adaptive full spectrum solar energy system having at least one hybrid solar concentrator, at least one hybrid luminaire, at least one hybrid photobioreactor, and a light distribution system operably connected to each hybrid solar concentrator, each hybrid luminaire, and each hybrid photobioreactor. A lighting control system operates each component.

  11. Adaptive Battery Charge Scheduling with Bursty Workloads

    E-Print Network [OSTI]

    Wu, Jie

    1 Adaptive Battery Charge Scheduling with Bursty Workloads Dylan Lexie , Shan Lin, and Jie Wu.wu@temple.edu Abstract--Battery-powered wireless sensor devices need to be charged to provide the desired functionality after deployment. Task or even device failures can occur if the voltage of the battery is low

  12. HAZARDOUS MATERIALS EMERGENCY RESPONSE

    E-Print Network [OSTI]

    ANNEX Q HAZARDOUS MATERIALS EMERGENCY RESPONSE #12;ANNEX Q - HAZARDOUS MATERIALS EMERGENCY RESPONSE 03/10/2014 v.2.0 Page Q-1 PROMULGATION STATEMENT Annex Q: Hazardous Materials Emergency Response, and contents within, is a guide to how the University conducts a response specific to a hazardous materials

  13. EMERGENCY RESPONSE EVACUATION PLAN

    E-Print Network [OSTI]

    Nicholson, Bruce J.

    EMERGENCY RESPONSE AND EVACUATION PLAN #12;Emergency Response and Evacuation Plan ­ June 2010 i EMERGENCY RESPONSE PHONE NUMBERS 2 PROCEDURES FOR REPORTING FIRE OR OTHER EMERGENCIES 3 RESPONSIBILITIES (EMPLOYEE/SUPERVISOR) 4 EMERGENCY EVACUATION PROCEDURES OVERVIEW 5 PROCEDURES FOR EVACUATING MOBILITY

  14. The Complexity of Adaptation to Climate Change. Exploring adaptation in Rio Grande, Ecuador 

    E-Print Network [OSTI]

    Argudo, Cristina

    2014-11-27

    Climate change has become one of the most challenging problems in terms of development, having adverse effects in populations that are already vulnerable to other stressors. At present, the importance of adaptation to climate change has been widely...

  15. Sodium pumps adapt spike bursting to stimulus Sara Arganda1,2,4, Raul Guantes1,3,4 & Gonzalo G de Polavieja1,2

    E-Print Network [OSTI]

    Guantes, Raúl

    Sodium pumps adapt spike bursting to stimulus statistics Sara Arganda1,2,4, Rau´l Guantes1,3,4 & Gonzalo G de Polavieja1,2 Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen

  16. Grid and basis adaptive polynomial chaos techniques for sensitivity and uncertainty analysis

    SciTech Connect (OSTI)

    Perkó, Zoltán Gilli, Luca Lathouwers, Danny Kloosterman, Jan Leen

    2014-03-01

    The demand for accurate and computationally affordable sensitivity and uncertainty techniques is constantly on the rise and has become especially pressing in the nuclear field with the shift to Best Estimate Plus Uncertainty methodologies in the licensing of nuclear installations. Besides traditional, already well developed methods – such as first order perturbation theory or Monte Carlo sampling – Polynomial Chaos Expansion (PCE) has been given a growing emphasis in recent years due to its simple application and good performance. This paper presents new developments of the research done at TU Delft on such Polynomial Chaos (PC) techniques. Our work is focused on the Non-Intrusive Spectral Projection (NISP) approach and adaptive methods for building the PCE of responses of interest. Recent efforts resulted in a new adaptive sparse grid algorithm designed for estimating the PC coefficients. The algorithm is based on Gerstner's procedure for calculating multi-dimensional integrals but proves to be computationally significantly cheaper, while at the same it retains a similar accuracy as the original method. More importantly the issue of basis adaptivity has been investigated and two techniques have been implemented for constructing the sparse PCE of quantities of interest. Not using the traditional full PC basis set leads to further reduction in computational time since the high order grids necessary for accurately estimating the near zero expansion coefficients of polynomial basis vectors not needed in the PCE can be excluded from the calculation. Moreover the sparse PC representation of the response is easier to handle when used for sensitivity analysis or uncertainty propagation due to the smaller number of basis vectors. The developed grid and basis adaptive methods have been implemented in Matlab as the Fully Adaptive Non-Intrusive Spectral Projection (FANISP) algorithm and were tested on four analytical problems. These show consistent good performance both in terms of the accuracy of the resulting PC representation of quantities and the computational costs associated with constructing the sparse PCE. Basis adaptivity also seems to make the employment of PC techniques possible for problems with a higher number of input parameters (15–20), alleviating a well known limitation of the traditional approach. The prospect of larger scale applicability and the simplicity of implementation makes such adaptive PC algorithms particularly appealing for the sensitivity and uncertainty analysis of complex systems and legacy codes.

  17. A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Davlieva, Milya; Shi, Yiwen; Leonard, Paul G.; Johnson, Troy A.; Zianni, Michael R.; Arias, Cesar A.; Ladbury, John E.; Shamoo, Yousif

    2015-04-19

    LiaR is a ‘master regulator’ of the cell envelope stress response in enterococci and many other Gram-positive organisms. Mutations to liaR can lead to antibiotic resistance to a variety of antibiotics including the cyclic lipopeptide daptomycin. LiaR is phosphorylated in response to membrane stress to regulate downstream target operons. Using DNA footprinting of the regions upstream of the liaXYZ and liaFSR operons we show that LiaR binds an extended stretch of DNA that extends beyond the proposed canonical consensus sequence suggesting a more complex level of regulatory control of target operons. We go on to determine the biochemical and structuralmore »basis for increased resistance to daptomycin by the adaptive mutation to LiaR (D191N) first identified from the pathogen Enterococcus faecalis S613. LiaRD191N increases oligomerization of LiaR to form a constitutively activated tetramer that has high affinity for DNA even in the absence of phosphorylation leading to increased resistance. The crystal structures of the LiaR DNA binding domain complexed to the putative consensus sequence as well as an adjoining secondary sequence show that upon binding, LiaR induces DNA bending that is consistent with increased recruitment of RNA polymerase to the transcription start site and upregulation of target operons.« less

  18. Virginia Tech Adaptive Sampling Simulator 1.0 Release Notes

    E-Print Network [OSTI]

    Virginia Tech

    Tech Adaptive Sampling Simulator provides the basic functionality to incorporate high fidelity netVirginia Tech Adaptive Sampling Simulator 1.0 Release Notes General Release 1.0 of the Virginia

  19. Funding for adaptation to climate change : the case of Surat

    E-Print Network [OSTI]

    Patel, Toral

    2014-01-01

    The need for cities to adapt to climate change is widely acknowledged, yet the question of adaptation finance remains uncertain. Unable to access global climate funds, cities must seek out alternative sources to support ...

  20. Adaptive Integrated Manufacturing Enterprises: Information Technology for the Next Decade

    E-Print Network [OSTI]

    Hsu, Cheng

    Adaptive Integrated Manufacturing Enterprises: Information Technology for the Next Decade Cheng Hsu for Manufacturing Productivity and Technology Transfer. #12;Abstract A new vision effecting adaptiveness Manufacturing Enterprises (AIME). It focuses on four major problems: (1) Management of multiple systems

  1. Adaptive Management in the Marine Renewable Energy Industry Webinar...

    Office of Environmental Management (EM)

    Adaptive Management in the Marine Renewable Energy Industry Webinar Adaptive Management in the Marine Renewable Energy Industry Webinar December 10, 2015 8:30AM to 10:00AM PST As...

  2. Adaptive array antenna design for wireless communication systems 

    E-Print Network [OSTI]

    Noordin, Nurul Hazlina

    2013-11-28

    Adaptive array antennas use has been limited to non-commercial applications due to their high cost and hardware complexity. The implementation cost of adaptive array antennas can be kept to a minimum by using cost effective ...

  3. Climate Change Adaptation: A Collective Action Perspective on Federalism Considerations

    E-Print Network [OSTI]

    Glicksman, Robert L.; Levy, Richard E.

    2010-01-01

    adaptation to minimize the adverse effects of climate change. Climate change adaptation is designed to increase the resilience of natural and human ecosystems to the threats posed by a changing environment. Although an extensive literature concerning...

  4. Genomic islands predict functional adaptation in marine actinobacteria

    E-Print Network [OSTI]

    Penn, Kevin

    2010-01-01

    Ecological adaptations among bacterial populations have been linked to genomic islands, strain-specific regions of DNA that house

  5. Communication adapter for use with a drilling component

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Pixton, David S. (Lehi, UT); Hall; Jr.; H. Tracy (Provo, UT); Bradford, Kline (Orem, UT); Rawle, Michael (Springville, UT)

    2007-04-03

    A communication adapter is disclosed that provides for removable attachment to a drilling component when the drilling component is not actively drilling and for communication with an integrated transmission system in the drilling component. The communication adapter comprises a data transmission coupler that facilitates communication between the drilling component and the adapter, a mechanical coupler that facilitates removable attachment of the adapter to the drilling component, and a data interface.

  6. BIA Request for Proposals for Climate Adaptation Grants for Tribes

    Broader source: Energy.gov [DOE]

    Download the Bureau of Indian Affairs Request for Proposals for Climate Adaptation Grants for Tribes, due November 29.

  7. Development based climate change adaptation and mitigation-conceptual...

    Open Energy Info (EERE)

    Topics: Adaptation, Co-benefits assessment, - Energy Access, - Energy Security, - Health Resource Type: Case studiesexamples, Lessons learnedbest practices, Publications...

  8. SILENCE: Distributed Adaptive Sampling for Sensor-based Autonomic Systems

    E-Print Network [OSTI]

    Pompili, Dario

    SILENCE: Distributed Adaptive Sampling for Sensor-based Autonomic Systems Eun Kyung Lee}@cac.rutgers.edu ABSTRACT Adaptive sampling and sleep scheduling can help realize the much needed resource efficiency phenomena. This paper presents a data-centric approach to distributed adaptive sampling aimed at minimizing

  9. www.carleton.ca/~kbstorey ADAPTATIONS TO COLD

    E-Print Network [OSTI]

    Storey, Kenneth B.

    12/19/2012 1 www.carleton.ca/~kbstorey ADAPTATIONS TO COLD Below 0°C Freeze Avoidance Freeze Supercool ADAPTATIONS TO COLD Below 0°C Freeze Avoidance Freeze Tolerance Hibernation Invertebrates Some Migrating DOWN #12;12/19/2012 3 Fresh Water Salt water ADAPTATIONS TO COLD Below 0°C Freeze Avoidance Freeze

  10. Some Computational Problems Arising in Adaptive Optics Imaging Systems

    E-Print Network [OSTI]

    Plemmons, Robert J.

    Some Computational Problems Arising in Adaptive Optics Imaging Systems Robert J. Plemmons \\Lambda numerical linear algebra tech­ niques in adaptive optics imaging control computations. Real­time adaptive optics is a means for enhancing the resolution of ground based, optical telescopes beyond the limits

  11. Phenotypic plasticity facilitates recurrent rapid adaptation to introduced predators

    E-Print Network [OSTI]

    Pfrender, Michael

    Phenotypic plasticity facilitates recurrent rapid adaptation to introduced predators Alison G) A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity

  12. Adaptive Optimizing Compilers for the 21st Century

    E-Print Network [OSTI]

    Subramanian, Devika

    Adaptive Optimizing Compilers for the 21st Century Los Alamos Computer Science Institute 2001 Houston, Texas, USA #12;Adaptive Optimizing Compilers 2 The Big Picture · For 45 years, compilers have Automatic Coding System (IBM, 1957) #12;Adaptive Optimizing Compilers 3 The Big Picture · RISC made

  13. Automated Web Page Synthesis in Adaptive Web Systems

    E-Print Network [OSTI]

    Ghorbani, Ali

    Automated Web Page Synthesis in Adaptive Web Systems Hossein Sadat and Ali Ghorbani Intelligent, Canada {t15h7,ghorbani}@unb.ca Abstract. An adaptive Web system adapts the Web pages to its users, based of the system. In this paper, we formalize dynamic generation of Web pages and refer to it as Web page synthesis

  14. ORIGINAL ARTICLE Situating adaptation: how governance challenges and perceptions

    E-Print Network [OSTI]

    Yung, Laurie

    Adaptation is situated within multiple, inter- acting social, political, and economic forces. Adaptation socio- political context. Pathways emphasize that current deci- sions are both informed by past actions and shape the landscape of future options. This research examines how adaptation actors in Grand County

  15. Adaptive Image Synthesis for Compressive Displays Felix Heide1

    E-Print Network [OSTI]

    Heidrich, Wolfgang

    Wolfgang Heidrich1 1 University of British Columbia 2 MIT Media Lab Figure 1: Adaptive light field-resolution target light field of 85 × 21 views with 840 × 525 pixels each (center). Our adaptive reconstruction usesAdaptive Image Synthesis for Compressive Displays Felix Heide1 Gordon Wetzstein2 Ramesh Raskar2

  16. Tangible Context Modelling for Rapid Adaptive System Testing

    E-Print Network [OSTI]

    Pfeifer, Holger

    , the adaptive behavior can even change the context by itself (e. g. switching the lights on causes the effectTangible Context Modelling for Rapid Adaptive System Testing Frank Honold, Felix Schüssel, Michael.honold, felix.schuessel, michael.munding, michael.weber}@uni-ulm.de Abstract--With the rise of adaptive

  17. A Pedagogical Interface for Authoring Adaptive e-Learning Courses

    E-Print Network [OSTI]

    Lau, W. H. Nynson

    different approaches towards learning. In light of this, adaptive educational hypermedia systems (AEHSsA Pedagogical Interface for Authoring Adaptive e-Learning Courses Christopher Watson1 Frederick W to support adaptive e-learning course authoring for different types of students. They require teachers

  18. Bayesian Color Estimation for Adaptive Vision-based Robot Localization

    E-Print Network [OSTI]

    Schulz, Dirk

    to variations in the lighting condition, a robot needs to adapt its color model to such changes. We propose that the robot can localize under different lighting conditions and adapt to changes in the lighting condition Gaussian color model which enables a robot to quickly adapt to different lighting conditions. The lower

  19. Adaptive Traffic Lights Using Car-to-Car Communication

    E-Print Network [OSTI]

    Iftode, Liviu

    Adaptive Traffic Lights Using Car-to-Car Communication Victor Gradinescu, Cristian Gorgorin, Raluca presents an adaptive traffic light system based on wireless communication between vehicles and fixed adaptive traffic light system. In section 4, we present the simulation framework we have developed

  20. Fitness Biasing Produce Adaptive Gaits for Hexapod Robots

    E-Print Network [OSTI]

    Parker, Gary B.

    Fitness Biasing Produce Adaptive Gaits for Hexapod Robots Gary Parker Computer Science Connecticut in an earlier work an effective learning cycles a hexapod robot. learning system capable of adapting to changes produce gaits hexapod robots difficult problem. particularly challenging if wants programs altered adapt

  1. APPLYING CACHING TO TWO-LEVEL ADAPTIVE BRANCH PREDICTION

    E-Print Network [OSTI]

    Vintan, Lucian N.

    - 1 - APPLYING CACHING TO TWO-LEVEL ADAPTIVE BRANCH PREDICTION EGAN, C., STEVEN, G. B., SHIM, W of the Camera-ready paper. #12;- 2 - APPLYING CACHING TO TWO-LEVEL ADAPTIVE BRANCH PREDICTION ABSTRACT During the 1990s Two-level Adaptive Branch Predictors were developed to meet the requirement for accurate branch

  2. FOCLASA 2009 Formalizing Adaptation On-the-Fly

    E-Print Network [OSTI]

    de Vink, Erik

    FOCLASA 2009 Formalizing Adaptation On-the-Fly S. Andovaa , L.P.J. Groenewegen1,b , J. Stafleub & E and new control in view of unforeseen adaptation. After addition McPal starts coordinating migration accordingly, adapting the system towards to-be collaboration. Once done, McPal removes obsolete control

  3. SU-E-J-153: MRI Based, Daily Adaptive Radiotherapy for Rectal Cancer: Contour Adaptation

    SciTech Connect (OSTI)

    Kleijnen, J; Burbach, M; Verbraeken, T; Weggers, R; Zoetelief, A; Reerink, O; Lagendijk, J; Raaymakers, B; Asselen, B [University Medical Center Utrecht, Utrecht (Netherlands)

    2014-06-01

    Purpose: A major hurdle in adaptive radiotherapy is the adaptation of the planning MRI's delineations to the daily anatomy. We therefore investigate the accuracy and time needed for online clinical target volume (CTV) adaptation by radiation therapists (RTT), to be used in MRI-guided adaptive treatments on a MRI-Linac (MRL). Methods: Sixteen patients, diagnosed with early stage rectal cancer, underwent a T2-weighted MRI prior to each fraction of short-course radiotherapy, resulting in 4–5 scans per patient. On these scans, the CTV was delineated according to guidelines by an experienced radiation oncologist (RO) and considered to be the gold standard. For each patient, the first MRI was considered as the planning MRI and matched on bony anatomy to the 3–4 daily MRIs. The planning MRI's CTV delineation was rigidly propagated to the daily MRI scans as a proposal for adaptation. Three RTTs in training started the adaptation of the CTV conform guidelines, after a two hour training lecture and a two patient (n=7) training set. To assess the inter-therapist variation, all three RTTs altered delineations of 3 patients (n=12). One RTT altered the CTV delineations (n=53) of the remaining 11 patients. Time needed for adaptation of the CTV to guidelines was registered.As a measure of agreement, the conformity index (CI) was determined between the RTTs' delineations as a group. Dice similarity coefficients were determined between delineations of the RTT and the RO. Results: We found good agreement between RTTs' and RO's delineations (average Dice=0.91, SD=0.03). Furthermore, the inter-observer agreement between the RTTs was high (average CI=0.94, SD=0.02). Adaptation time reduced from 10:33 min (SD= 3:46) to 2:56 min (SD=1:06) between the first and last ten delineations, respectively. Conclusion: Daily CTV adaptation by RTTs, seems a feasible and safe way to introduce daily, online MRI-based plan adaptation for a MRL.

  4. Demand Response and Electric Grid Reliability 

    E-Print Network [OSTI]

    Wattles, P.

    2012-01-01

    and Regional Transmission Organizations are the ?air traffic controllers? of the bulk electric power grids 4 Power supply (generation) must match load (demand) CATEE Conference October 10, 2012 ? The fundamental concept behind ERCOT operations... changes or incentives.? (FERC) ? ?Changes in electric use by demand-side resources from their normal consumption patterns in response to changes in the price of electricity, or to incentive payments designed to induce lower electricity use at times...

  5. Spectroscopic characterization of laser-induced tin plasma S. S. Harilal,a

    E-Print Network [OSTI]

    Harilal, S. S.

    using singly ionized Sn lines, while density measurements were made using the Stark broadening method deposition,5 nanoparticle and cluster production,6,7 and laser-induced breakdown spectroscopy LIBS .8 Laser setup very simple and adaptable to automation and remote sensing. Using OES one can obtain fundamental

  6. Noise-induced transitions vs. noise-induced phase transitions

    E-Print Network [OSTI]

    Toral, Raúl

    Noise-induced transitions vs. noise-induced phase transitions Raul Toral IFISC (Instituto de Física the field of noise-induced phase transitions, emphasizing the main differences with the phase-induced transitions and showing that they appear in different systems. I will show that a noise-induced transition can

  7. Linear response time-dependent density functional theory for van der Waals coefficients

    E-Print Network [OSTI]

    Chu, Xi

    Linear response time-dependent density functional theory for van der Waals coefficients X. Chu Received 9 January 2004; accepted 15 June 2004 A linear response time-dependent density functional theory description of the linear response function and of the induced self- consistent field, which adequately

  8. Modeling the Atmospheric Boundary Layer Wind Response to Mesoscale Sea Surface Temperature

    E-Print Network [OSTI]

    Kurapov, Alexander

    Modeling the Atmospheric Boundary Layer Wind Response to Mesoscale Sea Surface Temperature The wind speed response to mesoscale SST variability is investigated over the Agulhas Return Current region-Atmosphere Mesoscale Prediction System (COAMPS) atmospheric models. The SST-induced wind response is assessed from

  9. Spinning Reserve From Responsive Loads

    SciTech Connect (OSTI)

    Kirby, B.J.

    2003-04-08

    Responsive load is the most underutilized reliability resource available to the power system today. It is currently not used at all to provide spinning reserve. Historically there were good reasons for this, but recent technological advances in communications and controls have provided new capabilities and eliminated many of the old obstacles. North American Electric Reliability Council (NERC), Federal Energy Regulatory Commission (FERC), Northeast Power Coordinating Council (NPCC), New York State Reliability Council (NYSRC), and New York Independent System Operator (NYISO) rules are beginning to recognize these changes and are starting to encourage responsive load provision of reliability services. The Carrier ComfortChoice responsive thermostats provide an example of these technological advances. This is a technology aimed at reducing summer peak demand through central control of residential and small commercial air-conditioning loads. It is being utilized by Long Island Power Authority (LIPA), Consolidated Edison (ConEd), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E). The technology is capable of delivering even greater response in the faster spinning reserve time frame (while still providing peak reduction). Analysis of demand reduction testing results from LIPA during the summer of 2002 provides evidence to back up this claim. It also demonstrates that loads are different from generators and that the conventional wisdom, which advocates for starting with large loads as better ancillary service providers, is flawed. The tempting approach of incrementally adapting ancillary service requirements, which were established when generators were the only available resources, will not work. While it is easier for most generators to provide replacement power and non-spinning reserve (the slower response services) than it is to supply spinning reserve (the fastest service), the opposite is true for many loads. Also, there is more financial reward for supplying spinning reserve than for supplying the other reserve services as a result of the higher spinning reserve prices. The LIPAedge program (LIPA's demand reduction program using Carrier ComfortChoice thermostats) provides an opportunity to test the use of responsive load for spinning reserve. With potentially 75 MW of spinning reserve capability already installed, this test program can also make an important contribution to the capacity needs of Long Island during the summer of 2003. Testing could also be done at ConEd ({approx}30 MW), SCE ({approx}15 MW), and/or SDG&E ({approx}15 MW). This paper is divided into six chapters. Chapter 2 discusses the contingency reserve ancillary services, their functions in supporting power system reliability, and their technical requirements. It also discusses the policy and tariff requirements and attempts to distinguish between ones that are genuinely necessary and ones that are artifacts of the technologies that were historically used to provide the services. Chapter 3 discusses how responsive load could provide contingency reserves (especially spinning reserve) for the power system. Chapter 4 specifically discusses the Carrier ComfortChoice responsive thermostat technology, the LIPAedge experience with that technology, and how the technology could be used to supply spinning reserve. Chapter 5 discusses a number of unresolved issues and suggests areas for further research. Chapter 6 offers conclusions and recommendations.

  10. QAM Adaptive Measurements Feedback Quantum Receiver Performance

    E-Print Network [OSTI]

    Tian Chen; Ke Li; Yuan Zuo; Bing Zhu

    2015-04-11

    We theoretically study the quantum receivers with adaptive measurements feedback for discriminating quadrature amplitude modulation (QAM) coherent states in terms of average symbol error rate. For rectangular 16-QAM signal set, with different stages of adaptive measurements, the effects of realistic imperfection parameters including the sub-unity quantum efficiency and the dark counts of on-off detectors, as well as the transmittance of beam splitters and the mode mismatch factor between the signal and local oscillating fields on the symbol error rate are separately investigated through Monte Carlo simulations. Using photon-number-resolving detectors (PNRD) instead of on-off detectors, all the effects on the symbol error rate due to the above four imperfections can be suppressed in a certain degree. The finite resolution and PNR capability of PNRDs are also considered. We find that for currently available technology, the receiver shows a reasonable gain from the standard quantum limit (SQL) with moderate stages.

  11. Adaptive method for electron bunch profile prediction

    SciTech Connect (OSTI)

    Scheinker, Alexander; Gessner, Spencer

    2015-10-15

    We report on an experiment performed at the Facility for Advanced Accelerator Experimental Tests (FACET) at SLAC National Accelerator Laboratory, in which a new adaptive control algorithm, one with known, bounded update rates, despite operating on analytically unknown cost functions, was utilized in order to provide quasi-real-time bunch property estimates of the electron beam. Multiple parameters, such as arbitrary rf phase settings and other time-varying accelerator properties, were simultaneously tuned in order to match a simulated bunch energy spectrum with a measured energy spectrum. The simple adaptive scheme was digitally implemented using matlab and the experimental physics and industrial control system. Thus, the main result is a nonintrusive, nondestructive, real-time diagnostic scheme for prediction of bunch profiles, as well as other beam parameters, the precise control of which are important for the plasma wakefield acceleration experiments being explored at FACET.

  12. Adaptive synchronization of coupled chaotic oscillators

    E-Print Network [OSTI]

    Bhargava Ravoori; Adam B. Cohen; Anurag V. Setty; Francesco Sorrentino; Thomas E. Murphy; Edward Ott; Rajarshi Roy

    2009-10-05

    We experimentally demonstrate and numerically simulate a new adaptive method to maintain synchronization between coupled nonlinear chaotic oscillators, when the coupling between the systems is unknown and time-varying (e.g., due to environmental parameter drift). The technique is applied to optoelectronic feedback loops exhibiting high dimensional chaotic dynamics. In addition to keeping the two systems isochronally synchronized in the presence of a priori unknown time-varying coupling strength, the technique provides an estimate of the time-varying coupling.

  13. Adaptive complexity regularization for linear inverse problems

    E-Print Network [OSTI]

    Loubes, Jean-Michel

    2008-01-01

    We tackle the problem of building adaptive estimation procedures for ill-posed inverse problems. For general regularization methods depending on tuning parameters, we construct a penalized method that selects the optimal smoothing sequence without prior knowledge of the regularity of the function to be estimated. We provide for such estimators oracle inequalities and optimal rates of convergence. This penalized approach is applied to Tikhonov regularization and to regularization by projection.

  14. Adaptive Resource Management Schemes for Web Services 

    E-Print Network [OSTI]

    Lee, Heung Ki

    2011-02-22

    MANAGEMENT SCHEMES FOR WEB SERVICES A Dissertation by HEUNG KI LEE Submitted to the O?ce of Graduate Studies of Texas A&M University in partial fulflllment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2009 Major Subject: Computer...: Chair of Committee, Eun Jung Kim Committee Members, Riccardo Bettati Rabi N. Mahapatra Deepa Kundur Ki Hwan Yum Head of Department, Valerie E. Taylor December 2009 Major Subject: Computer Science iii ABSTRACT Adaptive Resource Management Schemes for Web...

  15. Page 1: Atanas Radenski: Anomaly-Free Component Adaptation with Class Overriding Anomaly-Free Component Adaptation with Class

    E-Print Network [OSTI]

    Radenski, Atanas

    Page 1: Atanas Radenski: Anomaly-Free Component Adaptation with Class Overriding Anomaly-Free Component Adaptation with Class Overriding Atanas Radenski Chapman University Department of Computer Science://www.chapman.edu/~radenski/ Abstract Software components can be implemented and distributed as collections of classes, then adapted

  16. Freezing-induced perturbation of tertiary structure of monoclonal antibody

    E-Print Network [OSTI]

    Liu, Lu; Kueltzo, L. A.; Jones, L. S.; Carpenter, J. F.

    2006-10-25

    Freezing-induced Perturbation of Tertiary Structure of Monoclonal Antibody Lu Liu, LaToya S. Jones, John F. Carpenter Center for Pharmaceutical Biotechnology, Department of Pharmaceutical Sciences, School of Pharmacy, University....e.,cryopreservation). ? However, freeze-thawing cycle usually results protein partially un- folding, and consequently forming aggregates, which may induce immunogenic response. ? Fluorescence spectroscopy is commonly used to study perturba- tions of protein tertiary structure...

  17. TECHNICAL STANDARDS PROGRAM RESPONSIBILITIES

    Broader source: Energy.gov [DOE]

    PurposeThis procedure describes the responsibilities of persons who are charged with implementing the DOE Technical Standards Program. 

  18. Adaptive powertrain control for plugin hybrid electric vehicles

    DOE Patents [OSTI]

    Kedar-Dongarkar, Gurunath; Weslati, Feisel

    2013-10-15

    A powertrain control system for a plugin hybrid electric vehicle. The system comprises an adaptive charge sustaining controller; at least one internal data source connected to the adaptive charge sustaining controller; and a memory connected to the adaptive charge sustaining controller for storing data generated by the at least one internal data source. The adaptive charge sustaining controller is operable to select an operating mode of the vehicle's powertrain along a given route based on programming generated from data stored in the memory associated with that route. Further described is a method of adaptively controlling operation of a plugin hybrid electric vehicle powertrain comprising identifying a route being traveled, activating stored adaptive charge sustaining mode programming for the identified route and controlling operation of the powertrain along the identified route by selecting from a plurality of operational modes based on the stored adaptive charge sustaining mode programming.

  19. Demand Response Assessment INTRODUCTION

    E-Print Network [OSTI]

    Demand Response Assessment INTRODUCTION This appendix provides more detail on some of the topics raised in Chapter 4, "Demand Response" of the body of the Plan. These topics include 1. The features, advantages and disadvantages of the main options for stimulating demand response (price mechanisms

  20. Method for removing tilt control in adaptive optics systems

    DOE Patents [OSTI]

    Salmon, J.T.

    1998-04-28

    A new adaptive optics system and method of operation are disclosed, whereby the method removes tilt control, and includes the steps of using a steering mirror to steer a wavefront in the desired direction, for aiming an impinging aberrated light beam in the direction of a deformable mirror. The deformable mirror has its surface deformed selectively by means of a plurality of actuators, and compensates, at least partially, for existing aberrations in the light beam. The light beam is split into an output beam and a sample beam, and the sample beam is sampled using a wavefront sensor. The sampled signals are converted into corresponding electrical signals for driving a controller, which, in turn, drives the deformable mirror in a feedback loop in response to the sampled signals, for compensating for aberrations in the wavefront. To this purpose, a displacement error (gradient) of the wavefront is measured, and adjusted by a modified gain matrix, which satisfies the following equation: G{prime} = (I{minus}X(X{sup T} X){sup {minus}1}X{sup T})G(I{minus}A). 3 figs.

  1. Method for removing tilt control in adaptive optics systems

    DOE Patents [OSTI]

    Salmon, Joseph Thaddeus (Livermore, CA)

    1998-01-01

    A new adaptive optics system and method of operation, whereby the method removes tilt control, and includes the steps of using a steering mirror to steer a wavefront in the desired direction, for aiming an impinging aberrated light beam in the direction of a deformable mirror. The deformable mirror has its surface deformed selectively by means of a plurality of actuators, and compensates, at least partially, for existing aberrations in the light beam. The light beam is split into an output beam and a sample beam, and the sample beam is sampled using a wavefront sensor. The sampled signals are converted into corresponding electrical signals for driving a controller, which, in turn, drives the deformable mirror in a feedback loop in response to the sampled signals, for compensating for aberrations in the wavefront. To this purpose, a displacement error (gradient) of the wavefront is measured, and adjusted by a modified gain matrix, which satisfies the following equation: G'=(I-X(X.sup.T X).sup.-1 X.sup.T)G(I-A)

  2. Adaptive Neural Networks for Automatic Negotiation

    SciTech Connect (OSTI)

    Sakas, D. P.; Vlachos, D. S.; Simos, T. E. [University of Peloponnese, 22100 Tripoli (Greece)

    2007-12-26

    The use of fuzzy logic and fuzzy neural networks has been found effective for the modelling of the uncertain relations between the parameters of a negotiation procedure. The problem with these configurations is that they are static, that is, any new knowledge from theory or experiment lead to the construction of entirely new models. To overcome this difficulty, we apply in this work, an adaptive neural topology to model the negotiation process. Finally a simple simulation is carried in order to test the new method.

  3. Adaptive Implicit Non-Equilibrium Radiation Diffusion

    SciTech Connect (OSTI)

    Philip, Bobby [ORNL; Wang, Zhen [ORNL; Berrill, Mark A [ORNL; Rodriguez Rodriguez, Manuel [ORNL; Pernice, Michael [Idaho National Laboratory (INL)

    2013-01-01

    We describe methods for accurate and efficient long term time integra- tion of non-equilibrium radiation diffusion systems: implicit time integration for effi- cient long term time integration of stiff multiphysics systems, local control theory based step size control to minimize the required global number of time steps while control- ling accuracy, dynamic 3D adaptive mesh refinement (AMR) to minimize memory and computational costs, Jacobian Free Newton-Krylov methods on AMR grids for efficient nonlinear solution, and optimal multilevel preconditioner components that provide level independent solver convergence.

  4. AfricaAdapt | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OFAMERICA'SHeavyAgencyTendoMassachusetts: EnergyRenewablesAfricaAfricaAdapt Jump

  5. African Adaptation Programme | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OFAMERICA'SHeavyAgencyTendoMassachusetts: EnergyRenewablesAfricaAfricaAdapt

  6. AdaptiveARC | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowaWisconsin: Energy Resources Jump to: navigation,Pennsylvania:AdaptiveARC

  7. A Comparative Analysis on Adaptive Modelling of Induced Feelings Zulfiqar A. Memon1,2

    E-Print Network [OSTI]

    Treur, Jan

    , Pakistan 3 COMSATS Institute of Information Technology, Department of Computer Science, Lahore, Pakistan

  8. CitiSense Adaptive Services for Community-Driven Behavioral and Environmental Monitoring to Induce

    E-Print Network [OSTI]

    Simunic, Tajana

    times nor at equal risk for asthma or other harmful consequences of air pollution. What if everyday RI³FLWL]HQ LQIUDVWUXFWXUH´ for the monitoring of pollution and environmental conditions that users by users, data about pollutants such as ozone and carbon monoxide is collected and used to provide real

  9. Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

    E-Print Network [OSTI]

    Heiman, Myriam

    Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal ...

  10. Automated Demand Response and Commissioning

    E-Print Network [OSTI]

    Piette, Mary Ann; Watson, David S.; Motegi, Naoya; Bourassa, Norman

    2005-01-01

    Fully-Automated Demand Response Test in Large Facilities14in DR systems. Demand Response using HVAC in Commercialof Fully Automated Demand Response in Large Facilities”

  11. Demand Response Spinning Reserve Demonstration

    E-Print Network [OSTI]

    2007-01-01

    F) Enhanced ACP Date RAA ACP Demand Response – SpinningReserve Demonstration Demand Response – Spinning Reservesupply spinning reserve. Demand Response – Spinning Reserve

  12. Demand Response Programs for Oregon

    E-Print Network [OSTI]

    Demand Response Programs for Oregon Utilities Public Utility Commission May 2003 Public Utility ....................................................................................................................... 1 Types of Demand Response Programs............................................................................ 3 Demand Response Programs in Oregon

  13. Real-Time Molecular Monitoring of Chemical Environment in Obligate Anaerobes during Oxygen Adaptive Response

    E-Print Network [OSTI]

    Holman, Hoi-Ying N.

    2009-01-01

    chemical environment by continuously monitoring the dynamicsMolecular Monitoring of Chemical Environment in Obligate

  14. A systems approach to uncovering the adaptive response of cancer to targeted therapies

    E-Print Network [OSTI]

    Randall, Adrian Joseph

    2012-01-01

    Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

  15. Response to Thomas and Baker: the structural adaptation of the brain to training

    E-Print Network [OSTI]

    Gaser, Christian

    , Germany In their letter to TiCS, Thomas and Baker rightly raise the question of whether training has sections of ten postmortem brains in MNI space. TICS-1041; No. of Pages 2 1 #12;of the great challenges

  16. Adaptive Finite Elements and Colliding Black Holes

    E-Print Network [OSTI]

    Douglas N. Arnold; Arup Mukherjee; Luc Pouly

    1997-09-15

    According to the theory of general relativity, the relative acceleration of masses generates gravitational radiation. Although gravitational radiation has not yet been detected, it is believed that extremely violent cosmic events, such as the collision of black holes, should generate gravity waves of sufficient amplitude to detect on earth. The massive Laser Interferometer Gravitational-wave Observatory, or LIGO, is now being constructed to detect gravity waves. Consequently there is great interest in the computer simulation of black hole collisions and similar events, based on the numerical solution of the Einstein field equations. In this note we introduce the scientific, mathematical, and computational problems and discuss the development of a computer code to solve the initial data problem for colliding black holes, a nonlinear elliptic boundary value problem posed in an unbounded three dimensional domain which is a key step in solving the full field equations. The code is based on finite elements, adaptive meshes, and a multigrid solution process. Here we will particularly emphasize the mathematical and algorithmic issues arising in the generation of adaptive tetrahedral meshes.

  17. GADRAS Detector Response Function.

    SciTech Connect (OSTI)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  18. Magnetically Responsive Photonic Structures

    E-Print Network [OSTI]

    Hu, Yongxing

    2011-01-01

    Crystals Introduction Colloidal crystals, typically self-NIPAM gel built with a colloidal crystal template composed2.6 (A) Photographs of colloidal crystals formed in response

  19. Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine

    E-Print Network [OSTI]

    Sridevi, P; Nhiayi, MK; Setten, RL; Wang, JYJ

    2013-01-01

    the DNA damage response (DDR) as a result of caspase-DNA fragmentation, and this DDR response contributes to23,24]. This caspase-induced DDR may explain the Tumor

  20. Role of phase instabilities in the early response of bulk fused...

    Office of Scientific and Technical Information (OSTI)

    Role of phase instabilities in the early response of bulk fused silica during laser-induced breakdown Citation Details In-Document Search Title: Role of phase instabilities in the...

  1. Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells 

    E-Print Network [OSTI]

    Chen, Chien-Cheng

    2009-06-02

    Estrogen receptor (ER) acts as a ligand-activated transcription factor that regulates the expression of genes. The genomic mechanisms of ER action include ligand-induced dimerization of ER which binds estrogen responsive ...

  2. First Characterization of Avian Memory T Lymphocyte Responses to Avian Influenza Virus Proteins 

    E-Print Network [OSTI]

    Singh, Shailbala

    2011-02-22

    responses induced by intramuscular inoculation of chickens with AIV HA and NP expressing cDNA plasmids or a non-replicating human adenovirus vector were identified through ex vivo stimulation with virus infected, major histocompatibility complex (MHC...

  3. Adaptive Injection Strategies (AIS) for Ultra-low Emissions Diesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Injection Strategies (AIS) for Ultra-low Emissions Diesel Engines Adaptive Injection Strategies (AIS) for Ultra-low Emissions Diesel Engines Presentation given at the 2007 Diesel...

  4. ADAPTIVE AND ROBUST TECHNIQUES (ART) FOR THERMOACOUSTIC TOMOGRAPHY

    E-Print Network [OSTI]

    Xie, Yao

    ADAPTIVE AND ROBUST TECHNIQUES (ART) FOR THERMOACOUSTIC TOMOGRAPHY By YAO XIE A DISSERTATION.1 Thermoacoustic Tomography . . . . . . . . . . . . . . . . . . . . . 1 1.2 Image Reconstruction Algorithms for TAT

  5. Adaptive finite element method for eddy current problems

    E-Print Network [OSTI]

    Adaptive finite element method for eddy current problems. In this chapter we shall discuss Maxwell's equations at very low frequencies. We also refer to [bo98 ...

  6. Sandia Energy - Structural and Mechanical Adaptive Rotor Technology...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Mechanical Adaptive Rotor Technology (SMART) Final Project Reports Published Home Renewable Energy Energy News Wind Energy News & Events Systems Analysis Structural and...

  7. Africa Adaptation Programme: Capacity Building Experiences-Improving...

    Open Energy Info (EERE)

    Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Africa Adaptation Programme: Capacity Building Experiences-Improving Access, Understanding and Application of Climate...

  8. Quantitative Adaptation Analytics for Assessing Dynamic Systems of Systems.

    SciTech Connect (OSTI)

    Gauthier, John H.; Miner, Nadine E.; Wilson, Michael L.; Le, Hai D.; Kao, Gio K; Melander, Darryl J.; Longsine, Dennis Earl; Vander Meer, Robert Charles,

    2015-01-01

    Our society is increasingly reliant on systems and interoperating collections of systems, known as systems of systems (SoS). These SoS are often subject to changing missions (e.g., nation- building, arms-control treaties), threats (e.g., asymmetric warfare, terrorism), natural environments (e.g., climate, weather, natural disasters) and budgets. How well can SoS adapt to these types of dynamic conditions? This report details the results of a three year Laboratory Directed Research and Development (LDRD) project aimed at developing metrics and methodologies for quantifying the adaptability of systems and SoS. Work products include: derivation of a set of adaptability metrics, a method for combining the metrics into a system of systems adaptability index (SoSAI) used to compare adaptability of SoS designs, development of a prototype dynamic SoS (proto-dSoS) simulation environment which provides the ability to investigate the validity of the adaptability metric set, and two test cases that evaluate the usefulness of a subset of the adaptability metrics and SoSAI for distinguishing good from poor adaptability in a SoS. Intellectual property results include three patents pending: A Method For Quantifying Relative System Adaptability, Method for Evaluating System Performance, and A Method for Determining Systems Re-Tasking.

  9. Economic Evaluation of Climate Change Adaptation Projects: Approaches...

    Open Energy Info (EERE)

    Economic Evaluation of Climate Change Adaptation Projects: Approaches for the Agricultural Sector and Beyond Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Economic...

  10. An adaptive wavelet stochastic collocation method for irregular...

    Office of Scientific and Technical Information (OSTI)

    paper we present a novel multi-dimensional multi-resolution adaptive (MdMrA) sparse grid stochastic collocation method, that utilizes hierarchical multiscale piecewise Riesz...

  11. Agricultural Technologies for Climate Change Mitigation and Adaptation...

    Open Energy Info (EERE)

    Technologies for Climate Change Mitigation and Adaptation in Developing Countries: Policy Options for Innovations and Technology Diffusion Jump to: navigation, search Tool...

  12. Applying Climate Information for Adaptation Decision-Making:...

    Open Energy Info (EERE)

    Applying Climate Information for Adaptation Decision-Making: A Guidance and Resource Document Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Applying Climate...

  13. Characterizing Uncertainty for Regional Climate Change Mitigation and Adaptation Decisions

    SciTech Connect (OSTI)

    Unwin, Stephen D.; Moss, Richard H.; Rice, Jennie S.; Scott, Michael J.

    2011-09-30

    This white paper describes the results of new research to develop an uncertainty characterization process to help address the challenges of regional climate change mitigation and adaptation decisions.

  14. CONTENT ADAPTIVE WATERMARKING BASED ON A STOCHASTIC MULTIRESOLUTION IMAGE

    E-Print Network [OSTI]

    Genève, Université de

    CONTENT ADAPTIVE WATERMARKING BASED ON A STOCHASTIC MULTIRESOLUTION IMAGE MODELING Sviatoslav to provide wa­ termark invisibility. Thirdly, a new principle of water­ mark spatial allocation, based

  15. Adaptive Stack with Subdivided Cells for Improved Stability,...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with Subdivided Cells for Improved Stability, Reliability, and Durability under Automotive Load Cycle Adaptive Stack with Subdivided Cells for Improved Stability, Reliability,...

  16. A method for online verification of adapted fields using an independent dose monitor

    SciTech Connect (OSTI)

    Chang Jina; Norrlinger, Bernhard D.; Heaton, Robert K.; Jaffray, David A.; Cho, Young-Bin; Islam, Mohammad K.; Mahon, Robert

    2013-07-15

    Purpose: Clinical implementation of online adaptive radiotherapy requires generation of modified fields and a method of dosimetric verification in a short time. We present a method of treatment field modification to account for patient setup error, and an online method of verification using an independent monitoring system.Methods: The fields are modified by translating each multileaf collimator (MLC) defined aperture in the direction of the patient setup error, and magnifying to account for distance variation to the marked isocentre. A modified version of a previously reported online beam monitoring system, the integral quality monitoring (IQM) system, was investigated for validation of adapted fields. The system consists of a large area ion-chamber with a spatial gradient in electrode separation to provide a spatially sensitive signal for each beam segment, mounted below the MLC, and a calculation algorithm to predict the signal. IMRT plans of ten prostate patients have been modified in response to six randomly chosen setup errors in three orthogonal directions.Results: A total of approximately 49 beams for the modified fields were verified by the IQM system, of which 97% of measured IQM signal agree with the predicted value to within 2%.Conclusions: The modified IQM system was found to be suitable for online verification of adapted treatment fields.

  17. 1. INTRODUCTION The following caution from the web site "Induced

    E-Print Network [OSTI]

    motions were produced by surface coal mining. They are compared to motions produced by two micro seismic were found to be similar to those produced by coal mine blasting. Since the ground motions were found to be similar, response of an instrumented test house to the coal mine blast- induced ground motions can

  18. SHORT COMMUNICATION Rhizobium Nod factors induce increases in intracellular free

    E-Print Network [OSTI]

    Kunkel, Joseph G.

    SHORT COMMUNICATION Rhizobium Nod factors induce increases in intracellular free calcium of Massachusetts, Box 35810, Amherst MA 01003±5810, USA Summary Application of Nod factors to growing, responsive region after 10±15 min treatment with Nod factors. The extracellular Ca2+ ¯ux, detected with the non

  19. Stress-induced changes in gene interactions in human cells

    E-Print Network [OSTI]

    Ives, Zachary G.

    Stress-induced changes in gene interactions in human cells Renuka R. Nayak1 , William E. Bernal2 environments by changing gene expression and gene interactions. To study how human cells response to stress, we endo- plasmic reticulum stress and exposure to ionizing radiation. We identified thousands of genes

  20. Eastern Frequency Response Study

    SciTech Connect (OSTI)

    Miller, N.W.; Shao, M.; Pajic, S.; D'Aquila, R.

    2013-05-01

    This study was specifically designed to investigate the frequency response of the Eastern Interconnection that results from large loss-of-generation events of the type targeted by the North American Electric Reliability Corp. Standard BAL-003 Frequency Response and Frequency Bias Setting (NERC 2012a), under possible future system conditions with high levels of wind generation.

  1. Responsive classroom management 

    E-Print Network [OSTI]

    Stough, Laura

    2008-01-01

    stream_source_info Responsive classroom management.pdf.txt stream_content_type text/plain stream_size 9 Content-Encoding ISO-8859-1 stream_name Responsive classroom management.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  2. Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway

    E-Print Network [OSTI]

    Brenner, David Jonathan

    and carcinogenesis. At doses above 50 millisievert, the radiation- induced cancer risk can be estimated based, these irradiated cells. There is evidence that very low doses of -particles induced clastogenic responses by a particle (3, 5, 9). In CHO cells irradiated with low doses of particles where 1% of the nuclei were

  3. Pollution-induced behavioural effects in the brown bullhead (Ameiurus nebulosus)

    E-Print Network [OSTI]

    Neff, Bryan D.

    Pollution-induced behavioural effects in the brown bullhead (Ameiurus nebulosus) Ross D. Breckels on biodiversity. Thus, it is important to understand the nature of pollution- induced change in aquatic ecosystems. We show that brown bullheads (Ameiurus nebulosus) may have evolved in response to chronic pollution

  4. OIKOS 89: 493500. Copenhagen 2000 Specificity of induced resistance in wild radish: causes and

    E-Print Network [OSTI]

    Agrawal, Anurag

    OIKOS 89: 493­500. Copenhagen 2000 Specificity of induced resistance in wild radish: causes. Specificity of induced resistance in wild radish: causes and consequences for two specialist and two to whether plant damage by various herbivores causes the same response in plants. Specificity in the effects

  5. Automatic Detection and Response to Environmental Change

    E-Print Network [OSTI]

    Veloso, Manuela M.

    conditions. This is useful for adapting to different lighting conditions or different flooring conditions of adapting to changing lighting conditions. The robot used in this work was built by Sony and is pictured to adapt to current operating conditions and the actions of other agents. Adapt- ing to current operating

  6. Current-induced torque driven ferromagnetic resonance in magnetic microstructures

    E-Print Network [OSTI]

    Fang, Dong

    2011-03-15

    of this Thesis a b Figure 1.2: An illustration of the spin-transfer torque effect in spin-valve device structures, adapted from [36]. a, A single magnetic layer with a spin- polarised electron passing through it. The magnet transmits and scatters the collinear... when an electric current passes through the pinned layer of a spin-valve, which can then act on the magnetisation in the free layer. 5 1.2 Context of this Thesis The current-induced torque in uniform ferromagnets has its origin in two quantum mechanical...

  7. Cross-Scale Responses of Biodiversity to Hurricane and

    E-Print Network [OSTI]

    Willig, Michael

    Cross-Scale Responses of Biodiversity to Hurricane and Anthropogenic Disturbance in a Tropical and Georges, as well as by patterns of historic land use. Hurricane-induced changes in spatial organization changed after the hurricanes and were significantly different between Hurricanes Hugo and Georges. Alpha

  8. Model-reference adaptive control applied to load-following of a space-nuclear power system

    SciTech Connect (OSTI)

    Metzger, J.D.; El-Genk, M.S.; Parlos, A.G.; New Mexico Univ., Albuquerque, NM . Inst. for Space Nuclear Power Studies; Texas A and M Univ., College Station, TX . Dept. of Nuclear Engineering)

    1989-01-01

    Nuclear power systems are presently being investigated as an alternative for both commercial and military space power systems because of their projected longevity of 7 to 10 years, their mass advantage over other space power sources at powers above approximately 25 kW{sub e}, and their ability to operate without direct illumination from the sun. These space-nuclear power systems are being designed to supply from tens of kilowatts to multimegawatts of power for continuous operation of seven years and more. Space-nuclear power systems designs that meet these requirements will not be available for refueling or maintenance during their lifetime. To ensure that the space-nuclear power system will operate safely and will respond in a predictable and desired manner, the design of the system's controller must account for changes in the system parameters over its lifetime. This paper applies model-reference adaptive control to an increase in the power demand by the load. A model-reference adaptive controller will force the actual space-nuclear power system to follow the predictable and desired response of a reference model, despite changes in the actual system's operating parameters. Included in this paper are the model-reference adaptive control algorithm, the description of the computer simulation of a space-nuclear power system and the reference model, and results that demonstrate the application of model-reference adaptive control to a change in the load power demand. The results demonstrate that model-reference adaptive control can ensure the transient response of the system despite differences between the design of the system and the as-built system as well as for variations in the systems parameters. 5 refs., 3 figs.

  9. Optically Induced Transparency

    E-Print Network [OSTI]

    Zheng, Yuanlin; Shen, Zhenhua; Cao, Jianjun; Chen, Xianfeng; Liang, Xiaogan; Wan, Wenjie

    2015-01-01

    Light-matter-light interactions serve as the backbone technology of all-optical information processing for both on-chip and long-haul communication purposes. The representative example of electromagnetically induced transparency has its unique ability of optically controlling transparency windows with relative low light in atomic systems, though its practical applications are limited due to rigid experimental requirements. Here we demonstrate a new form of optically induced transparency in a micro-cavity by introducing four-wave mixing gain in order to couple nonlinearly two separated resonances of the micro-cavity in ambient environment. A signature Fano-like resonance is also observed owing to the nonlinear interference of two coupled resonances. Moreover, we show that the unidirectional gain of four-wave mixing can lead to non-reciprocal transmission at the transparency windows. Optically induced transparency may offer a unique platform for a compact, integrated solution to all-optical processing and quant...

  10. Adaptable radiation monitoring system and method

    DOE Patents [OSTI]

    Archer, Daniel E. (Livermore, CA); Beauchamp, Brock R. (San Ramon, CA); Mauger, G. Joseph (Livermore, CA); Nelson, Karl E. (Livermore, CA); Mercer, Michael B. (Manteca, CA); Pletcher, David C. (Sacramento, CA); Riot, Vincent J. (Berkeley, CA); Schek, James L. (Tracy, CA); Knapp, David A. (Livermore, CA)

    2006-06-20

    A portable radioactive-material detection system capable of detecting radioactive sources moving at high speeds. The system has at least one radiation detector capable of detecting gamma-radiation and coupled to an MCA capable of collecting spectral data in very small time bins of less than about 150 msec. A computer processor is connected to the MCA for determining from the spectral data if a triggering event has occurred. Spectral data is stored on a data storage device, and a power source supplies power to the detection system. Various configurations of the detection system may be adaptably arranged for various radiation detection scenarios. In a preferred embodiment, the computer processor operates as a server which receives spectral data from other networked detection systems, and communicates the collected data to a central data reporting system.

  11. Adaptive model training system and method

    DOE Patents [OSTI]

    Bickford, Randall L; Palnitkar, Rahul M; Lee, Vo

    2014-04-15

    An adaptive model training system and method for filtering asset operating data values acquired from a monitored asset for selectively choosing asset operating data values that meet at least one predefined criterion of good data quality while rejecting asset operating data values that fail to meet at least the one predefined criterion of good data quality; and recalibrating a previously trained or calibrated model having a learned scope of normal operation of the asset by utilizing the asset operating data values that meet at least the one predefined criterion of good data quality for adjusting the learned scope of normal operation of the asset for defining a recalibrated model having the adjusted learned scope of normal operation of the asset.

  12. Adaptive model training system and method

    DOE Patents [OSTI]

    Bickford, Randall L; Palnitkar, Rahul M

    2014-11-18

    An adaptive model training system and method for filtering asset operating data values acquired from a monitored asset for selectively choosing asset operating data values that meet at least one predefined criterion of good data quality while rejecting asset operating data values that fail to meet at least the one predefined criterion of good data quality; and recalibrating a previously trained or calibrated model having a learned scope of normal operation of the asset by utilizing the asset operating data values that meet at least the one predefined criterion of good data quality for adjusting the learned scope of normal operation of the asset for defining a recalibrated model having the adjusted learned scope of normal operation of the asset.

  13. Adaptive control for semilinear stochastic systems

    E-Print Network [OSTI]

    Duncan, Tyrone E.; Maslowski, Bozenna J.; Pasik-Duncan, B.

    2000-01-01

    (t) = u˜(X(t)), is also considered where u˜ ? ˜ U and ˜ U = {u˜ : H ? B R | u˜ is Borel measurable}.(2.3) The cost functionals J(x, ?, u) and ˜ J(x, u) are given as J(x, ?, u) = E x,u ? ? 0 e ??t (?(X(t)) + h(u(t)))dt(2.4) and ˜ J(x, u) = lim inf T?? E x... of the unknown parameter ? and to determine an adaptive control from the family of admissible controls such that the optimal ergodic cost, inf u?U ˜ J(x, u), is achieved. The following assumptions are selectively used in the paper. (A1) The linear operator Q = Q...

  14. Wavefront Control for Extreme Adaptive Optics

    SciTech Connect (OSTI)

    Poyneer, L A

    2003-07-16

    Current plans for Extreme Adaptive Optics systems place challenging requirements on wave-front control. This paper focuses on control system dynamics, wave-front sensing and wave-front correction device characteristics. It may be necessary to run an ExAO system after a slower, low-order AO system. Running two independent systems can result in very good temporal performance, provided specific design constraints are followed. The spatially-filtered wave-front sensor, which prevents aliasing and improves PSF sensitivity, is summarized. Different models of continuous and segmented deformable mirrors are studied. In a noise-free case, a piston-tip-tilt segmented MEMS device can achieve nearly equivalent performance to a continuous-sheet DM in compensating for a static phase aberration with use of spatial filtering.

  15. Forecasting changes in population genetic structure of alpine plants in response to global warming

    E-Print Network [OSTI]

    François, Olivier

    Forecasting changes in population genetic structure of alpine plants in response to global warming the European Alps, we applied this approach to 20 alpine plant species considering a global increase populations potentially adapted to warmer environments and other populations. While a global trend of movement

  16. Distributed Multi-Period Optimal Power Flow for Demand Response in Microgrids

    E-Print Network [OSTI]

    Yeoh, William

    Distributed Multi-Period Optimal Power Flow for Demand Response in Microgrids Paul Scott1 direction method of multipliers (ADMM), can be adapted to remain practical in this challenging microgrid discrete decisions. Our experiments on a suburb-sized microgrid show that the AC power flows and a simple

  17. On Using Complex Event Processing for Dynamic Demand Response Optimization in Microgrid

    E-Print Network [OSTI]

    Hwang, Kai

    On Using Complex Event Processing for Dynamic Demand Response Optimization in Microgrid Qunzhi Zhou Processing (CEP) patterns to model and detect dynamic situations in a campus microgrid to facilitate adaptive these patterns on realtime events in the USC Campus microgrid using our CEP framework. Index Terms

  18. Neutron-induced nucleosynthesis

    E-Print Network [OSTI]

    H. Oberhummer; H. Herndl; T. Rauscher; H. Beer

    1996-08-20

    Neutron--induced nucleosynthesis plays an important role in astrophysical scenarios like in primordial nucleosynthesis in the early universe, in the s--process occurring in Red Giants, and in the $\\alpha$--rich freeze--out and r--process taking place in supernovae of type II. A review of the three important aspects of neutron--induced nucleosynthesis is given: astrophysical background, experimental methods and theoretical models for determining reaction cross sections and reaction rates at thermonuclear energies. Three specific examples of neutron capture at thermal and thermonuclear energies are discussed in some detail.

  19. Salient features in locomotor evolutionary adaptations of proboscideans revealed via the differential scaling of limb long bones

    E-Print Network [OSTI]

    Kokshenev, Valery B

    2009-01-01

    The standard differential scaling of proportions in limb long bones (length against circumference) is applied to a phylogenetically wide sample of the Proboscidea, Elephantidae and the Asian (Elephas maximus) and African elephant (Loxodonta africana). In order to investigate allometric patterns in proboscideans and terrestrial mammals with parasagittal limb kinematics, the computed slopes (slenderness exponents) are compared with published values for mammals and studied within a framework of theoretical models of long bone scaling under gravity and muscle forces. Limb bone allometry in E. maximus and the Elephantidae are congruent with adaptation to bending and/or torsion induced by muscular forces during fast locomotion, as in other mammals, whereas limb bones in L. africana appear adapted for coping with the compressive forces of gravity. Consequently, hindlimb bones are expected to be more compliant than forelimb bones in accordance with in vivo studies on elephant locomotory kinetics and kinematics, and t...

  20. Extreme Adaptive Optics Testbed: High Contrast Measurements with a MEMS Deformable Mirror

    SciTech Connect (OSTI)

    Evans, J W; Morzinski, K; Reza, L; Severson, S; Poyneer, L; Macintosh, B; Dillon, D; Sommargren, G

    2005-08-16

    ''Extreme'' adaptive optics systems are optimized for ultra-high-contrast applications, such as ground-based extrasolar planet detection. The Extreme Adaptive Optics Testbed at UC Santa Cruz is being used to investigate and develop technologies for high-contrast imaging, especially wavefront control. We use a simple optical design to minimize wavefront error and maximize the experimentally achievable contrast. A phase shifting diffraction interferometer (PSDI) measures wavefront errors with sub-nm precision and accuracy for metrology and wavefront control. Previously, we have demonstrated RMS wavefront errors of <1.5 nm and a contrast of >10{sup 7} over a substantial region using a shaped pupil without a deformable mirror. Current work includes the installation and characterization of a 1024-actuator Micro-Electro-Mechanical-Systems (MEMS) deformable mirror, manufactured by Boston Micro-Machines for active wavefront control. Using the PSDI as the wavefront sensor we have flattened the deformable mirror to <1 nm within the controllable spatial frequencies and measured a contrast in the far field of >10{sup 6}. Consistent flattening required testing and characterization of the individual actuator response, including the effects of dead and low-response actuators. Stability and repeatability of the MEMS devices was also tested. Ultimately this testbed will be used to test all aspects of the system architecture for an extrasolar planet-finding AO system.

  1. Lead User's theory adapted to services: Towards Service User's Toolkit

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Lead User's theory adapted to services: Towards Service User's Toolkit E. Stevens Prof under the perspective of networks and communities. Lead User's theory (LUT) focused mainly is to adapt lead user's theory and practice to the specific case of the intangible processes and services

  2. Fast Concurrent Dynamic Linking for an Adaptive Operating System

    E-Print Network [OSTI]

    Walpole, Jonathan

    Fast Concurrent Dynamic Linking for an Adaptive Operating System Crispin Cowan, Tito Autrey operating system is one that can adapt to some particular circumstance to gain some functional or perfor due to the cost of inter-process protection barriers. Commercial operating systems that can e ciently

  3. CONTEXTUALLY ADAPTIVE SIGNAL REPRESENTATION USING CONDITIONAL PRINCIPAL COMPONENT ANALYSIS

    E-Print Network [OSTI]

    Rajashekar, Umesh

    is the construction of bases that are adapted to individual signal in- stances. Here we develop a new framework. Index Terms-- Adaptive basis, conditional PCA, self-similarities, image modeling, image representation traditional methods, primarily due to the cost of encoding the indices of selected basis elements

  4. The evolution of imitation and mirror neurons in adaptive agents

    E-Print Network [OSTI]

    Borenstein, Elhanan

    The evolution of imitation and mirror neurons in adaptive agents Action editor: Luc Berthouze evolutionary adaptive agents that demonstrate imitative learn- ing, facilitating a comprehensive study The past 20 years have seen a renewed interest in imitation in various fields of research (Prinz & 1389

  5. On Adaptive Mesh Refinement for Atmospheric Pollution Models

    E-Print Network [OSTI]

    Sandu, Adrian

    On Adaptive Mesh Refinement for Atmospheric Pollution Models Emil M. Constantinescu and Adrian res- olution system for modeling regional air pollution based on the chemical transport model STEM. Keywords: Air Pollution Modeling, Adaptive Mesh Refinement. 1 Introduction Inadequate grid resolution can

  6. Hardware Implementation of the LMS Adaptive Filter for a

    E-Print Network [OSTI]

    Slatton, Clint

    Hardware Implementation of the LMS Adaptive Filter for a Brain-Machine Interface March 13, 2002@cnel.ufl.edu Advisors: Dr. José C. Principe Dr. Karl Gugel #12;Outline · Introduction · BMI Project Overview · LMS Adaptive Filter · TI C33 DSP · C33 PCI Development Board · Mathematics in DSP · LMS in DSP · Results

  7. MEANSQUARE ANALYSIS OF THE MULTIPLEERROR AND BLOCK LMS ADAPTIVE ALGORITHMS

    E-Print Network [OSTI]

    Douglas, Scott C.

    MEAN­SQUARE ANALYSIS OF THE MULTIPLE­ERROR AND BLOCK LMS ADAPTIVE ALGORITHMS S. C. Douglas filters share a common multiple­error LMS algorithm update, given by W k+1 = W k +¯X k (D k \\Gamma X T k W k ): (1) In this paper, we examine the mean­square per­ formance of the multiple­error LMS adaptive

  8. ADAPTIVE FINITE ELEMENT FREQUENCY DOMAIN METHOD FOR EDDY CURRENT PROBLEMS

    E-Print Network [OSTI]

    Zheng, Weiying

    ADAPTIVE FINITE ELEMENT FREQUENCY DOMAIN METHOD FOR EDDY CURRENT PROBLEMS WEIYING ZHENG-harmonic eddy current problems in the case of three-dimensional isotropic and linear materials. We adopt. Time-harmonic Maxwell's equations, eddy current, adaptive finite element method, multiply connected

  9. SERVICE OUTAGE BASED ADAPTIVE TRANSMISSION IN FADING CHANNELS

    E-Print Network [OSTI]

    Yates, Roy

    SERVICE OUTAGE BASED ADAPTIVE TRANSMISSION IN FADING CHANNELS BY JIANGHONG LUO A dissertation OF THE DISSERTATION Service Outage Based Adaptive Transmission in Fading Channels by Jianghong Luo Dissertation Director: Prof. Roy Yates, Prof. Predrag Spasojevi´c The service outage based allocation problem explores

  10. WIND SPEED VARIABILITY AND ADAPTATION STRATEGIES IN COASTAL AREAS

    E-Print Network [OSTI]

    Kohfeld, Karen

    WIND SPEED VARIABILITY AND ADAPTATION STRATEGIES IN COASTAL AREAS OF THE PACIFIC NORTHWEST of Thesis: Wind Speed Variability and Adaptation Strategies in Coastal Areas of the Pacific Northwest/Approved: ___________________________________________ #12;iii ABSTRACT Overall, previous wind speed studies in the Pacific Northwest (PNW) present

  11. Optimizing Monitoring Requirements in Self-Adaptive , Alberto Griggio2

    E-Print Network [OSTI]

    the system environment is a key functionality of a self- adaptive system. Monitoring requirements denoteOptimizing Monitoring Requirements in Self-Adaptive Systems Raian Ali1 , Alberto Griggio2 , Anders Kessler, Italy 3 Jasper Design Automation, Sweden 4 DISI, University of Trento, Italy Abstract. Monitoring

  12. 9 Towards Adaptive Management of Native Vegetation in Regional Landscapes

    E-Print Network [OSTI]

    Burgman, Mark

    in the approach to defining management objectives and specifying assumptions behind vegetation change models9 Towards Adaptive Management of Native Vegetation in Regional Landscapes David H Duncan1 of the `adaptive management' paradigm to natural resource man- agement, using regional management of native

  13. Power-Efficient Adaptable Wireless Sensor Networks , David Evans2

    E-Print Network [OSTI]

    Evans, David

    Power-Efficient Adaptable Wireless Sensor Networks John Lach1 , David Evans2 , Jon McCune3 , Jason the flexibility necessary for the adaptations required of wireless sensor networks without the penalties Engineering3 , Pittsburgh, PA 15213 Abstract Wireless sensor networks represent a new data collection paradigm

  14. Rate Adaptation in MIMO Antenna Selection System with Imperfect CSIT

    E-Print Network [OSTI]

    Bhashyam, Srikrishna

    constant power and rate will lead to block errors during the poor channel conditions or under utilization that encompasses feedback delay, estimation errors and prediction. However, rate adaptation has not been consideredRate Adaptation in MIMO Antenna Selection System with Imperfect CSIT T. R. Ramya and Srikrishna

  15. Adaptive Grids for Weather and Climate Models C. Jablonowski

    E-Print Network [OSTI]

    Stout, Quentin F.

    Adaptive Grids for Weather and Climate Models C. Jablonowski National Center for Atmospheric have been discussed in the literature. Nested-grid approaches are widely used at National Weather.: ADAPTIVE GRIDS FOR WEATHER AND CLIMATE MODELS two grids coincide. Other variable-resolution models

  16. AN INVESTIGATION INTO SUBSPACE RAPID SPEAKER ADAPTATION FOR VERIFICATION

    E-Print Network [OSTI]

    Chen, Tsuhan

    verification. 1. INTRODUCTION The rapid adaptation of speaker models for the purposes of speaker verification topic, with current state of the art speaker verification sys- tems based on hidden Markov models (HMMsAN INVESTIGATION INTO SUBSPACE RAPID SPEAKER ADAPTATION FOR VERIFICATION Simon Lucey and Tsuhan

  17. 2003 Special issue Statistical efficiency of adaptive algorithms

    E-Print Network [OSTI]

    Widrow, Bernard

    2003 Special issue Statistical efficiency of adaptive algorithms Bernard Widrow*, Max Kamenetsky Serra Mall, Stanford, CA 94305, USA Abstract The statistical efficiency of a learning algorithm applied gradient descent adaptive algorithms are compared, the LMS algorithm and the LMS/Newton algorithm. LMS

  18. SPRING 2012 MATH 750-Stochastic Adaptive Control Theory

    E-Print Network [OSTI]

    Pasik-Duncan, Bozenna

    SPRING 2012 MATH 750-Stochastic Adaptive Control Theory CLASS HOURS: 1:00­ 2:15, WF, 564 Snow Hall adaptive control theory is concerned with recursive estimation of unknown parameters and control, manufacturing processes, and financial economics. Mathematical theory of identification, control and stochastic

  19. Are three-dimensional spider webs defensive adaptations?

    E-Print Network [OSTI]

    Blackledge, Todd

    LETTER Are three-dimensional spider webs defensive adaptations? Todd A. Blackledge1 *, Jonathan A-mail: tab42@cornell.edu Abstract Spider webs result from complex behaviours that have evolved under many selective pressures. Webs have been primarily considered to be foraging adaptations, neglecting

  20. Energy Efficient Routing with Adaptive Data Fusion in Sensor Networks

    E-Print Network [OSTI]

    Liu, Yonghe

    Energy Efficient Routing with Adaptive Data Fusion in Sensor Networks Hong Luo College of Computer Adaptive Fusion Steiner Tree (AFST), for energy efficient data gathering in sensor networks that jointly, other networks may require complex operations for data fusion1 . Energy consumption of beamforming

  1. Appears in the SIGGRAPH 2001 Conference Proceedings. Adaptive Shadow Maps

    E-Print Network [OSTI]

    Bala, Kavita

    Appears in the SIGGRAPH 2001 Conference Proceedings. Adaptive Shadow Maps Randima Fernando introduce aliasing. This paper introduces the Adaptive Shadow Map (ASM) as a solution to this problem. An ASM removes aliasing by resolving pixel size mismatches between the eye view and the light source view

  2. Performance of Subaru adaptive optics system and the scientific results

    E-Print Network [OSTI]

    Iye, Masanori

    Performance of Subaru adaptive optics system and the scientific results Hideki Takami*a , Naruhisa Institute, Heidelberg ABSTRACT We present an overview of Subaru Cassegrain adaptive optics system and its light in Dec. 2000. The AO system has been in service for two instruments, IRCS; infrared camera

  3. Adaptive Optics at the Subaru Telescope: current capabilities and development

    E-Print Network [OSTI]

    Guyon, Olivier

    Adaptive Optics at the Subaru Telescope: current capabilities and development Olivier Guyona Barbara, CA 93106, USA ABSTRACT Adaptive optics is a key component of Subaru Telescope's current-limited images in near-IR. In its LGS mode, laser light is transported from the solid state laser to the launch

  4. A low cost adaptive optics system using a membrane mirror

    E-Print Network [OSTI]

    Dainty, Chris

    A low cost adaptive optics system using a membrane mirror C. Paterson, I. Munro and J. C. Dainty 2BZ, UK carlp@ic.ac.uk Abstract: A low cost adaptive optics system constructed almost en- tirely a diffractive wavefront generator based on a ferroelectric spatial light modulator. This is used to produce

  5. Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish

    E-Print Network [OSTI]

    Monteiro, Antónia

    Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish W. R. JEFFERY Department degeneration in cave-adapted animals have not been resolved. Opposing hypotheses invoking neural mutation-dwelling forms (cavefish), which shed new light on this problem. The manner of eye development and degeneration

  6. Plane-wave fluorescence tomography with adaptive finite elements

    E-Print Network [OSTI]

    Bangerth, Wolfgang

    Plane-wave fluorescence tomography with adaptive finite elements Amit Joshi Photon Migration reflectance imaging setup. The method employs planar illumination with modulated light and frequency domain fluo- rescence measurements made on the illumination plane. An adaptive finite-element algorithm

  7. Adaptive Probabilistic Visual Tracking with Incremental Subspace Update

    E-Print Network [OSTI]

    Yang, Ming-Hsuan

    Adaptive Probabilistic Visual Tracking with Incremental Subspace Update David Ross1 , Jongwoo Lim2 of the objects being tracked are invariant to internal appearance change or external variation such as lighting at the outset. In this paper, we present an adaptive probabilistic tracking algorithm that updates the models

  8. Adaptive subwavelength control of nano-optical Martin Aeschlimann1

    E-Print Network [OSTI]

    Aeschlimann, Martin

    LETTERS Adaptive subwavelength control of nano-optical fields Martin Aeschlimann1 , Michael Bauer2 , Christian Spindler3 & Felix Steeb1 Adaptive shaping of the phase and amplitude of femtosecond laser pulses to approximately half the wavelength of the light field (that is, several hundred nanometres). Theory has indicated

  9. Color Halftoning with Stochastic Dithering and Adaptive Clustering

    E-Print Network [OSTI]

    de Figueiredo, Luiz Henrique

    Color Halftoning with Stochastic Dithering and Adaptive Clustering Luiz Velho, Jonas Gomes IMPA.). In this paper we introduce a new halftoning technique for color reproduction. The algorithm adapts to a wide Color Separation and Halftoning Color printing is based on a reflective light process. The ink

  10. Adaptive Independence Samplers J. M. Keith a,1,2

    E-Print Network [OSTI]

    Kroese, Dirk P.

    Adaptive Independence Samplers J. M. Keith a,1,2 , D. P. Kroese b,1 , G. Yu. Sofronov b,1, a and mixing properties. One way to accelerate convergence and mixing is to adapt the proposal distribution in light of previously sampled points, thus increasing the prob- ability of acceptance. In this paper, we

  11. Towards a Repulsive and Adaptive Particle Swarm Optimization Algorithm

    E-Print Network [OSTI]

    Ludwig, Simone

    proposes a Repulsive Adaptive PSO (RAPSO) variant that adaptively optimizes the velocity weights of ev- ery particle at every iteration. RAPSO optimizes the ve- locity weights during every outer PSO iteration, and opti- mizes the solution of the problem in an inner PSO iteration. We compare RAPSO to Global Best PSO

  12. View-Dependent Articulated-Body Simulation with Adaptive Forward

    E-Print Network [OSTI]

    View-Dependent Articulated-Body Simulation with Adaptive Forward Dynamics Daseong Han KAIST (Korea Advanced Institute of Science and Technology) #12;2 Outline Introduction Related Work Simulation Levels and Conquer Algorithm(DCA) For Forward Dynamics Adaptive Forward Dynamics(AFD) View-dependent Forward

  13. A Hybrid RNS Adaptive Filter for Channel Equalization

    E-Print Network [OSTI]

    A Hybrid RNS Adaptive Filter for Channel Equalization G.L. Bernocchi, G.C. Cardarilli, A. Del Re, A-- In this work a hybrid Residue Number System (RNS) implementation of an adaptive FIR filter is presented or echo cancellation). In the literature, it has been shown that the RNS implementation of FIR filters

  14. Adaptive Optics in Astronomy Jay J. McCarthy

    E-Print Network [OSTI]

    La Rosa, Andres H.

    Adaptive Optics in Astronomy Jay J. McCarthy NW Computational Intelligence Laboratory Portland State University Abstract ­ The field of adaptive optics (AO) has developed as a means to correct for the phase disturbances of an optical signal by understanding the medium through which it passes. This paper

  15. DYNAMIC IMAGE SIMULATIONS FOR ADAPTIVE SENSOR PERFORMANCE PREDICTIONS

    E-Print Network [OSTI]

    Kerekes, John

    devices such as MEMS-based micromirrors can be modeled, but the desired overall sensor application oftenDYNAMIC IMAGE SIMULATIONS FOR ADAPTIVE SENSOR PERFORMANCE PREDICTIONS Michael D. Presnara,b , John is necessary for predicting real-life performance of adaptive sensor models. Physics-based modeling

  16. AN ADAPTIVE SURFACE FINITE ELEMENT METHOD BASED ON VOLUME MESHES

    E-Print Network [OSTI]

    Demlow, Alan

    studied in this paper. The paper of Dziuk [12] contains the first analysis of a finite element methodAN ADAPTIVE SURFACE FINITE ELEMENT METHOD BASED ON VOLUME MESHES ALAN DEMLOW AND MAXIM A. OLSHANSKII Abstract. In this paper we define an adaptive version of a recently introduced finite element

  17. Pacific Adaptation Strategy Assistance Program Dynamical Seasonal Forecasting

    E-Print Network [OSTI]

    Lim, Eun-pa

    Adaptation Strategy Assistance Program El Nino Mean State · Easterlies westward surface current upwelling warmer & thermocline is deep eastward undercurrent El Nino ·+ve Bjerknes feedback Easterlies break down and Kelvin wavesEl Nino Equatorial Kelvin wave Off-equatorial Rossby wave #12;Pacific Adaptation Strategy

  18. ADAPTIVE OPTICAL SIGNAL PROCESSING FOR MICROWAVE-CARRIER BROADBAND SIGNALS

    E-Print Network [OSTI]

    Popovic, Zoya

    ADAPTIVE OPTICAL SIGNAL PROCESSING FOR MICROWAVE-CARRIER BROADBAND SIGNALS Paul Smith, Zoya Popovic antenna array in which adaptive processing of the received signals is performed by dynamic holographic to other signal-processing algorithms is also discussed. 1. INTRODUCTION A key challenge to present

  19. A Stochastic Approach to Content Adaptive Digital Image Watermarking

    E-Print Network [OSTI]

    Genève, Université de

    A Stochastic Approach to Content Adaptive Digital Image Watermarking Sviatoslav Voloshynovskiy y z and strength for the water­ mark embedding stage. We examine two such NVFs, based on either a non of the watermark estimation is equivalent to image denoising and derive content adaptive criteria. Re­ sults show

  20. A Stochastic Approach to Content Adaptive Digital Image Watermarking

    E-Print Network [OSTI]

    Genève, Université de

    A Stochastic Approach to Content Adaptive Digital Image Watermarking Sviatoslav Voloshynovskiyyz function, that allows us to determine the optimal watermark locations and strength for the water- mark to image denoising and derive content adaptive criteria. Re- sults show that watermark visibility

  1. Validating the Evaluation of Adaptive Systems by User Profile Simulation

    E-Print Network [OSTI]

    Bravo, Javier

    a simulation-based technique is proposed as an economic way for testing evaluation tools based on log analysisValidating the Evaluation of Adaptive Systems by User Profile Simulation Javier Bravo and Alvaro.ortigosa}@uam.es Abstract. Availability of automated tools and methods to evaluate adaptive systems is a fundamental

  2. ADAPTIVE MODELLING IN THE DESIGN OF INTERACTIVE DEVICES

    E-Print Network [OSTI]

    Prabhakar, Sattiraju

    are created by adapting old designs. The present work is motivated by two issues in building a computational in evolutionary design often are small, simple, local and routine. But evolutionary design in general includes of the device. But now consider the problem of adapting the design of a waterwheel to harness wind energy

  3. ADAPTIVE ONLINE ENERGY SAVING FOR HETEROGENEOUS SENSOR Meikang Qiu1

    E-Print Network [OSTI]

    Sha, Edwin

    ADAPTIVE ONLINE ENERGY SAVING FOR HETEROGENEOUS SENSOR NETWORKS Meikang Qiu1 Jingtong Hu2 Edwin H-to-predict environments and have limited lifetime. We use a novel adaptive online energy saving (AOES) algorithm to save as a probabilistic random variable to save energy by se- lecting the best mode assignment for each node, which

  4. AN ADAPTIVE FINITE ELEMENT METHOD FOR THE WAVE ...

    E-Print Network [OSTI]

    2015-09-09

    Consider the acoustic wave scattering by an impenetrable obstacle in two dimensions. ... adaptive finite element algorithm is proposed for solving the acoustic ... element methods [19,20] and the boundary integral equation methods [11]. ...... rem 4.1, we use the PDE toolbox of MATLAB to implement the adaptive algorithm of.

  5. Modeling and Adaptive Control of Indoor Unmanned Aerial Vehicles

    E-Print Network [OSTI]

    Modeling and Adaptive Control of Indoor Unmanned Aerial Vehicles by Bernard Michini B;Modeling and Adaptive Control of Indoor Unmanned Aerial Vehicles by Bernard Michini Submitted for the degree of Master of Science in Aeronautics and Astronautics Abstract The operation of unmanned aerial

  6. Adaptive vibration control using synchronous demodulation with machine tool controller motor commutation

    DOE Patents [OSTI]

    Hopkins, David James (Livermore, CA)

    2008-05-13

    A control system and method for actively reducing vibration in a spindle housing caused by unbalance forces on a rotating spindle, by measuring the force-induced spindle-housing motion, determining control signals based on synchronous demodulation, and provide compensation for the measured displacement to cancel or otherwise reduce or attenuate the vibration. In particular, the synchronous demodulation technique is performed to recover a measured spindle housing displacement signal related only to the rotation of a machine tool spindle, and consequently rejects measured displacement not related to spindle motion or synchronous to a cycle of revolution. Furthermore, the controller actuates at least one voice-coil (VC) motor, to cancel the original force-induced motion, and adapts the magnitude of voice coil signal until this measured displacement signal is brought to a null. In order to adjust the signal to a null, it must have the correct phase relative to the spindle angle. The feedback phase signal is used to adjust a common (to both outputs) commutation offset register (offset relative to spindle encoder angle) to force the feedback phase signal output to a null. Once both of these feedback signals are null, the system is compensating properly for the spindle-induced motion.

  7. Frequency Response Analysis Tool

    SciTech Connect (OSTI)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  8. Shrouded inducer pump

    DOE Patents [OSTI]

    Meng, S.Y.

    1989-08-08

    An improvement in a pump is described including a shrouded inducer, the improvement comprising first and second sealing means which cooperate with a first vortex cell and a series of secondary vortex cells to remove any tangential velocity components from the recirculation flow. 3 figs.

  9. M. Flierl: Adaptive Spatial Wavelets for Motion-Compensated Orthogonal Video Transforms, IEEE ICIP, Cairo, Egypt, Nov. 2009. 1 ADAPTIVE SPATIAL WAVELETS FOR MOTION-COMPENSATED

    E-Print Network [OSTI]

    Flierl, Markus

    , Cairo, Egypt, Nov. 2009. 1 ADAPTIVE SPATIAL WAVELETS FOR MOTION-COMPENSATED ORTHOGONAL VIDEO TRANSFORMS

  10. Adaptive and Non-Adaptive ISI Sparse Channel Estimation Based on SL0 and Its Application in

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Adaptive and Non-Adaptive ISI Sparse Channel Estimation Based on SL0 and Its Application in ML presented in [1] for estimation of sparse In- ter Symbol Interface (ISI) channels which will appear method based on SL0 sparse signal representation is proposed. ISI channel estimation will have a direct

  11. INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. 2008; 22:968986

    E-Print Network [OSTI]

    Efe, Mehmet Önder

    INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal.ku Kasnako~glu Department of Electrical and Electronics Engineering, TOBB Economics and Technology University, S¨og¨ut¨oz¨u Cad. No. 43, TR-06560 S¨og¨ut¨oz¨u, Ankara, Turkey SUMMARY This paper presents a novel

  12. Adapt-Traf: An adaptive multiagent road traffic management system based on hybrid ant-hierarchical fuzzy model

    E-Print Network [OSTI]

    Casillas Barranquero, Jorge

    of the energy consumption, and others. Road traffic management consists on improving the traffic fluency on roadAdapt-Traf: An adaptive multiagent road traffic management system based on hybrid ant systems Ant colony Hierarchical fuzzy system Traffic simulation a b s t r a c t Usually, road networks

  13. Design, Construction, and On-sky Performance of a MEMS-based uplink-Adaptive Optics System

    E-Print Network [OSTI]

    Norton, Andrew

    2014-01-01

    of Laser-Uplink Adaptive Optics for Astronomicalguidestar Adaptive Optics . . . . . . . . . 3.0.2 Producingand with (right) adaptive optics. The stars have a 0.3 arc

  14. Characterization Of High-Stroke High-Aspect Ratio Micro Electro Mechanical Systems Deformable Mirrors For Adaptive Optics

    E-Print Network [OSTI]

    Bouchti, Mohamed Amine

    2013-01-01

    Mirrors For Adaptive Optics, PhD Thesis, University ofFabrication Adaptive  optics  applications  in  astronomy  Max, Center for Adaptive Optics, University of California,

  15. Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation

    E-Print Network [OSTI]

    2008-01-01

    imaging with adaptive optics in patients with inheritedAdaptive Optics Scanning Laser Ophthalmoscopy Images in aof cone structure using adaptive optics scanning laser

  16. The Responsibilities of Engineers 

    E-Print Network [OSTI]

    Smith, Justin Douglas 1978-

    2012-12-06

    Knowledge of the responsibilities of engineers is key to answering ethical questions about the work of engineers, because the decisions made by engineers often have ethical dimensions and implications. Engineers develop and implement technologies...

  17. Response Resources Demonstration

    Office of Environmental Management (EM)

    be in New York City as opposed to Westchester for the fuel cell. New York City has higher electricity prices and higher demand response payments available. Also it wasn't clear if...

  18. Responsibility, Incompetence, and Psychopathy

    E-Print Network [OSTI]

    Brink, David O.

    2013-04-30

    that is significantly more demanding than a recognitional standard, especially if we focus on basic morality and the criminal law. The fair opportunity conception of responsibility seems to require only a recognitional capacity and perhaps a gradeability capacity... that is significantly more demanding than a recognitional standard, especially if we focus on basic morality and the criminal law. The fair opportunity conception of responsibility seems to require only a recognitional capacity and perhaps a gradeability capacity...

  19. Adaptive dynamic inversion of nonlinear systems subjected to control saturation constraints 

    E-Print Network [OSTI]

    Tandale, Monish Deepak

    2007-09-17

    The adaptive dynamic inversion control methodology uses dynamic inversion to calculate the control, and adaptation to compensate for the errors in the inversion due to model uncertainties. Traditionally, adaptive control assumes full authority...

  20. Development and Use of Curricular Adaptations for Students Receiving Special Education Services

    E-Print Network [OSTI]

    Kurth, Jennifer A.; Keegan, Lissa

    2012-11-30

    This study is a quasi-experimental descriptive design, with existing educator-made adaptations evaluated. The goals of this study were to (a) describe how educators develop adaptations and (b) evaluate the effectiveness of educator-made adaptations...

  1. Experimental Fluorescence Optical Tomography using Adaptive Finite Elements and Planar Illumination with

    E-Print Network [OSTI]

    Bangerth, Wolfgang

    Experimental Fluorescence Optical Tomography using Adaptive Finite Elements and Planar Illumination with Modulated Excitation Light Amit Joshia , Wolfgang Bangerthb , Alan B. Thompsona , and Eva M. Sevick adaptive discretization strategies. To date, the efficacy of adaptive mesh refinement techniques has yet

  2. Essays on Agricultural Adaptation to Climate Change and Ethanol Market Integration in the U.S. 

    E-Print Network [OSTI]

    Aisabokhae, Ruth 1980-

    2012-12-05

    Model (FASOM) shows adaptation to be highly beneficial to agriculture. On-farm varietal and other adaptations contributions outweigh a mix shift northwards significantly, implying progressive technical change and significant returns to adaptation...

  3. Adaptive protocols for mobile ad hoc networks 

    E-Print Network [OSTI]

    Holland, Gavin Douglas

    2005-02-17

    to take advantage of the presence of multirate links. We then investigate the performance of iv TCP, showing how communication outages caused by link failures and routing delays can be very detrimental to its performance. In response, we present a solution.... : : : : : : : : : : : : : : : : : : : : : : : : 62 15 Performance of RBAR when a simple heuristic is used by the sender to try and predict the best data rate for the conditions, in an e?ort to reduce the frequency of the necessity for reservation subheaders...

  4. Modeling Power Systems as Complex Adaptive Systems

    SciTech Connect (OSTI)

    Chassin, David P.; Malard, Joel M.; Posse, Christian; Gangopadhyaya, Asim; Lu, Ning; Katipamula, Srinivas; Mallow, J V.

    2004-12-30

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today's most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This report explores the state-of-the-art physical analogs for understanding the behavior of some econophysical systems and deriving stable and robust control strategies for using them. We review and discuss applications of some analytic methods based on a thermodynamic metaphor, according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood. We apply these methods to the question of how power markets can be expected to behave under a variety of conditions.

  5. GRChombo : Numerical Relativity with Adaptive Mesh Refinement

    E-Print Network [OSTI]

    Clough, Katy; Finkel, Hal; Kunesch, Markus; Lim, Eugene A; Tunyasuvunakool, Saran

    2015-01-01

    Numerical relativity has undergone a revolution in the past decade. With a well-understood mathematical formalism, and full control over the gauge modes, it is now entering an era in which the science can be properly explored. In this work, we introduce GRChombo, a new numerical relativity code written to take full advantage of modern parallel computing techniques. GRChombo's features include full adaptive mesh refinement with block structured Berger-Rigoutsos grid generation which supports non-trivial "many-boxes-in-many-boxes" meshing hierarchies, and massive parallelism through the Message Passing Interface (MPI). GRChombo evolves the Einstein equation with the standard BSSN formalism, with an option to turn on CCZ4 constraint damping if required. We show that GRChombo passes all the standard "Apples-to-Apples" code comparison tests. We also show that it can stably and accurately evolve vacuum black hole spacetimes such as binary black hole mergers, and non-vacuum spacetimes such as scalar collapses into b...

  6. Laser-Induced Breakdown Spectroscopy

    E-Print Network [OSTI]

    Nizkorodov, Sergey

    LIBS-1 Laser-Induced Breakdown Spectroscopy LIBS ANALYSIS OF METAL SURFACES Last updated: June 17, 2014 #12;LIBS-2 Laser­Induced Breakdown Spectroscopy (LIBS) LIBS ANALYSIS OF METAL SURFACES of species at a distance or in hard­to­reach or hazardous environments. Laser­Induced Breakdown Spectroscopy

  7. Demand Response Valuation Frameworks Paper

    E-Print Network [OSTI]

    Heffner, Grayson

    2010-01-01

    No. ER06-615-000 CAISO Demand Response Resource User Guide -8 2.1. Demand Response Provides a Range of Benefits to8 2.2. Demand Response Benefits can be Quantified in Several

  8. Thermoacoustic wave propagation modeling using a dynamically adaptive wavelet collocation method

    SciTech Connect (OSTI)

    Vasilyev, O.V.; Paolucci, S.

    1996-12-31

    When a localized region of a solid wall surrounding a compressible medium is subjected to a sudden temperature change, the medium in the immediate neighborhood of that region expands. This expansion generates pressure waves. These thermally-generated waves are referred to as thermoacoustic (TAC) waves. The main interest in thermoacoustic waves is motivated by their property to enhance heat transfer by inducing convective motion away from the heated area. Thermoacoustic wave propagation in a two-dimensional rectangular cavity is studied numerically. The thermoacoustic waves are generated by raising the temperature locally at the walls. The waves, which decay at large time due to thermal and viscous diffusion, propagate and reflect from the walls creating complicated two-dimensional patterns. The accuracy of numerical simulation is ensured by using a highly accurate, dynamically adaptive, multilevel wavelet collocation method, which allows local refinements to adapt to local changes in solution scales. Subsequently, high resolution computations are performed only in regions of large gradients. The computational cost of the method is independent of the dimensionality of the problem and is O(N), where N is the total number of collation points.

  9. Electromagnetically Induced Entanglement

    E-Print Network [OSTI]

    Xihua Yang; Min Xiao

    2015-05-18

    We present a novel quantum phenomenon named electromagnetically induced entanglement in the conventional Lambda-type three-level atomic system driven by a strong pump field and a relatively weak probe field. Nearly perfect entanglement between the pump and probe fields can be achieved with a low coherence decay rate between the two lower levels, high pump-field intensity, and large optical depth of the atomic ensemble. The physical origin is quantum coherence between the lower doublet produced by the pump and probe fields, similar to the well-known electromagnetically induced transparency. This method would greatly facilitate the generation of nondegenerate narrow-band continuous-variable entanglement between bright light beams by using only coherent laser fields, and may find potential and broad applications in realistic quantum information processing.

  10. Advancing Adaptive Optics Technology: Laboratory Turbulence Simulation and Optimization of Laser Guide Stars

    E-Print Network [OSTI]

    Rampy, Rachel

    2013-01-01

    of cone photoreceptors with adaptive optics spectral-domaincoherence tomography,” Optics Express, Vol. 14, Issue 10,of Multi-Object Adaptive Optics on a Simulated 10-Meter

  11. U.S. Department of Energy Climate Change Adaptation Policy Statement...

    Energy Savers [EERE]

    Climate Change Adaptation Policy Statement U.S. Department of Energy Climate Change Adaptation Policy Statement U.S. Department of Energy statement that commits the agency to...

  12. The effects of background adaptation and food availability on habitat preference of Corythoichthys flavofasciatus

    E-Print Network [OSTI]

    Iyer, Neetha

    2012-01-01

    ADAPTATION AND FOOD AVAILABILITY ON HABITAT PREFERENCE OFchoice is related to the availability of food, presence ofbackground adaptation, food availability, or a combination

  13. Multigrid elliptic equation solver with adaptive mesh refinement

    E-Print Network [OSTI]

    J. David Brown; Lisa L. Lowe

    2005-03-22

    In this paper we describe in detail the computational algorithm used by our parallel multigrid elliptic equation solver with adaptive mesh refinement. Our code uses truncation error estimates to adaptively refine the grid as part of the solution process. The presentation includes a discussion of the orders of accuracy that we use for prolongation and restriction operators to ensure second order accurate results and to minimize computational work. Code tests are presented that confirm the overall second order accuracy and demonstrate the savings in computational resources provided by adaptive mesh refinement.

  14. Shear-Induced Chaos

    E-Print Network [OSTI]

    Kevin K. Lin; Lai-Sang Young

    2007-05-23

    Guided by a geometric understanding developed in earlier works of Wang and Young, we carry out some numerical studies of shear-induced chaos. The settings considered include periodic kicking of limit cycles, random kicks at Poisson times, and continuous-time driving by white noise. The forcing of a quasi-periodic model describing two coupled oscillators is also investigated. In all cases, positive Lyapunov exponents are found in suitable parameter ranges when the forcing is suitably directed.

  15. Photomechanical Response of Molecular Nanostructures

    E-Print Network [OSTI]

    Pechenezhskiy, Ivan Viktorovich

    2014-01-01

    Induced by Light and Thermal Activation”, J. Phys. Chem. Cinduced by light and thermal activation”, Chem. Phys. Lett.

  16. TESTING THE APODIZED PUPIL LYOT CORONAGRAPH ON THE LABORATORY FOR ADAPTIVE OPTICS EXTREME ADAPTIVE OPTICS TESTBED

    SciTech Connect (OSTI)

    Thomas, Sandrine J.; Dillon, Daren; Gavel, Donald [Laboratory for Adaptive Optics, University of California/Lick Observatories, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Macintosh, Bruce [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94550 (United States); Sivaramakrishnan, Anand, E-mail: sthomas@ucolick.org, E-mail: dillon@ucolick.org, E-mail: gavel@ucolick.org, E-mail: soummer@stsci.edu, E-mail: macintosh1@mail.llnl.gov, E-mail: anand@amnh.org [Department of Astrophysics, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024 (United States)

    2011-10-15

    We present testbed results of the Apodized Pupil Lyot Coronagraph (APLC) at the Laboratory for Adaptive Optics (LAO). These results are part of the validation and tests of the coronagraph and of the Extreme Adaptive Optics (ExAO) for the Gemini Planet Imager (GPI). The apodizer component is manufactured with a halftone technique using black chrome microdots on glass. Testing this APLC (like any other coronagraph) requires extremely good wavefront correction, which is obtained to the 1 nm rms level using the microelectricalmechanical systems (MEMS) technology, on the ExAO visible testbed of the LAO at the University of Santa Cruz. We used an APLC coronagraph without central obstruction, both with a reference super-polished flat mirror and with the MEMS to obtain one of the first images of a dark zone in a coronagraphic image with classical adaptive optics using a MEMS deformable mirror (without involving dark hole algorithms). This was done as a complementary test to the GPI coronagraph testbed at American Museum of Natural History, which studied the coronagraph itself without wavefront correction. Because we needed a full aperture, the coronagraph design is very different from the GPI design. We also tested a coronagraph with central obstruction similar to that of GPI. We investigated the performance of the APLC coronagraph and more particularly the effect of the apodizer profile accuracy on the contrast. Finally, we compared the resulting contrast to predictions made with a wavefront propagation model of the testbed to understand the effects of phase and amplitude errors on the final contrast.

  17. Optimal Demand Response Libin Jiang

    E-Print Network [OSTI]

    Optimal Demand Response Libin Jiang Steven Low Computing + Math Sciences Electrical Engineering Caltech Oct 2011 #12;Outline Caltech smart grid research Optimal demand response #12;Global trends 1

  18. Logarithmic transformation of response Logarithmic transformation of response

    E-Print Network [OSTI]

    Komarek, Arnost

    Logarithmic transformation of response Logarithmic transformation of response Often, support S of Y is S = (0, ). Logarithm is then one of transformations to consider when trying to obtain a correct (wrong. Model Building 1. Transformation of response #12;Logarithmic transformation of response When does

  19. A Dynamic Island Model for Adaptive Operator Selection Caner Candan

    E-Print Network [OSTI]

    Goëffon, Adrien

    A Dynamic Island Model for Adaptive Operator Selection Caner Candan LERIA - University of Angers Angers, France caner.candan@univ-angers.fr Adrien Goëffon LERIA - University of Angers Angers, France

  20. Building (as) performance : a material approach to adaptive architecture

    E-Print Network [OSTI]

    Dimitrov, Andrey

    2009-01-01

    One measure of performance in adaptive architecture is its ability the respond effectively to the environment and evolving program. As architects strive to create designs that respond to external change, more and more ...