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1

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system  

DOE Patents [OSTI]

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Kieper, Douglas Arthur (Newport News, VA); Majewski, Stanislaw (Yorktown, VA); Welch, Benjamin L. (Hampton, VA)

2008-10-28T23:59:59.000Z

2

AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER  

E-Print Network [OSTI]

AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER Marius George LINGURARU, Oxford OX2 7BZ, United Kingdom mglin@robots.ox.ac.uk Abstract: The prevalence of breast cancer must provide effective clinical methods to detect cancer and improve life expectancy. Considerable

Paris-Sud XI, Université de

3

Detecting Discrepancies and Improving Intelligibility  

E-Print Network [OSTI]

Detecting Discrepancies and Improving Intelligibility: Two Preliminary Evaluations of RIPTIDES evaluations of RIPTIDES, a sys- tem that combines information extraction (IE), extraction-based sum unduly sacrificing content relevance. 1 Introduction We report on two preliminary evaluations of RIPTIDES

Wagstaff, Kiri L.

4

Neutron Imaging Explored as Complementary Technique for Improving Cancer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron Imaging Explored as Complementary Technique for Improving Cancer Neutron Imaging Explored as Complementary Technique for Improving Cancer Detection August 05, 2013 Researcher Maria Cekanova analyzes the neutron radiographs of a canine breast tumor (black color in top image of monitor screen) using the software to visualize in color the various intensities of neutron transmissions through the breast tissue. ORNL and University of Tennessee collaboration now analyzing first results from neutron radiographs of cancerous tissue samples Today's range of techniques for detection of breast and other cancers include mammography, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET), and optical imaging. Each technology has advantages and disadvantages, with limitations either

5

Improving Screening Strategies for Prostate Cancer.  

E-Print Network [OSTI]

??abstractTh is thesis describes research on screening for prostate cancer. To improve understanding of the thesis, some background information will be provided in this introduction.… (more)

T. Wolters (Tineke)

2010-01-01T23:59:59.000Z

6

Nanoparticle assay detects prostate cancer  

Science Journals Connector (OSTI)

MedWire News: US researchers have developed a nanoparticle assay that distinguishes cancerous prostate tissue from...

2012-05-01T23:59:59.000Z

7

Early Lung Cancer Detection Program  

Broader source: Energy.gov [DOE]

Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

8

Improving the detection ...1 Improving the detection of On-line Vertical Port Scan  

E-Print Network [OSTI]

Improving the detection ...1 Improving the detection of On-line Vertical Port Scan Improving the detection of On-line Vertical Port Scan in IP Traffic Yousra Chabchoub , Christine Fricker and Philippe to detect port scan attacks in IP traffic. Only relevant information about destination IP addresses

Paris-Sud XI, Université de

9

Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam  

E-Print Network [OSTI]

Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

Petta, Jason

10

Nanotechnology in Cancer Treatment and Detection Richard Acosta  

E-Print Network [OSTI]

Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation ·Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

Fygenson, Deborah Kuchnir

11

Physician-driven education to improve disparity in colorectal cancer  

Science Journals Connector (OSTI)

...Behavioral and Social Science Community-based Interventions: Poster Presentations AACR...Conference: The Science of Cancer Health...Physician-driven education to improve disparity...Conference on the Science of Cancer Health...

Timothy Woodward; Monica Albertie; Garik Nicholson; Kenneth Vega; Renard Rawls; and Gerardo Colon-Otero

2007-11-01T23:59:59.000Z

12

Improved Microseismicity Detection During Newberry EGS Stimulations  

SciTech Connect (OSTI)

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Dennise Templeton

2013-11-01T23:59:59.000Z

13

Improved Microseismicity Detection During Newberry EGS Stimulations  

SciTech Connect (OSTI)

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Dennise Templeton

2013-10-01T23:59:59.000Z

14

Improved Microseismicity Detection During Newberry EGS Stimulations  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Templeton, Dennise

15

Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer  

E-Print Network [OSTI]

Pretargeted radioimmunotherapy (PRIT) of cancer improves upon conventional radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have ...

Zajic, Stefan C

2007-01-01T23:59:59.000Z

16

Improved method for detection of starch hydrolysis  

SciTech Connect (OSTI)

A new starch hydrolysis detection method which does not rely on iodine staining or the use of color-complexed starch is described. A linear relationship was obtained with agar-starch plates when net clearing zones around colonies of yeasts were plotted against enzyme levels (semilogarithm scale) produced by the same yeast strains in liquid medium. A similar relationship between starch clearing zones and alpha-amylase levels from three different sources was observed. These observations suggest that the method is useful in mutant isolations, strain improvement programs, and the prediction of alpha-amylase activities in culture filtrates or column effluents. (Refs. 18).

Ohawale, M.R.; Wilson, J.J.; Khachatourians, G.G.; Ingledew, W.M.

1982-09-01T23:59:59.000Z

17

E-Print Network 3.0 - advanced cancer detection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: advanced cancer detection Page: << < 1 2 3 4 5 > >> 1 The Cancer Risk Clinic Cancer Risk Clinical...

18

6.21 Improving Neutron Beams for Cancer Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 612011 6.21 Improving Neutron Beams for Cancer Treatment Beams of neutrons long have been used in scientific experiments, but recently, for the first time, a novel type of...

19

IMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES  

E-Print Network [OSTI]

IMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES Mat´ias Di Martino, Federico of fraud makes this a very complex task. In this paper we present a fraud detection strategy based on class Nontechnical losses represent a very high cost to power supply companies, who aims to improve fraud detection

20

Former Worker Program - Early Lung Cancer Detection Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Reducing emissions to improve nuclear test detection | National...  

National Nuclear Security Administration (NNSA)

Reducing emissions to improve nuclear test detection | National Nuclear Security Administration People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear...

22

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents [OSTI]

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

23

Theranostic nanomedicine for cancer detection and treatment  

Science Journals Connector (OSTI)

Abstract Cancer is the second leading cause of death in the USA according to the American Cancer Society. In the past 5 years, “theranostic nanomedicine”, for both therapeutics and imaging, has shown to be “the right drug for the right patient at the right moment” to manage deadly cancers. This review article presents an overview of recent developments, mainly from the authors' laboratories, along with potential medical applications for theranostic nanomedicine including basic concepts and critical properties. Finally, we outline the future research direction and possible challenges for theranostic nanomedicine research.

Zhen Fan; Peter P. Fu; Hongtao Yu; Paresh C. Ray

2014-01-01T23:59:59.000Z

24

Improving tamper detection for hazardous waste security  

SciTech Connect (OSTI)

After September 11, waste managers are increasingly expected to provide improved levels of security for the hazardous materials in their charge. Many low-level wastes that previously had minimal or no security must now be well protected, while high-level wastes require even greater levels of security than previously employed. This demand for improved security comes, in many cases, without waste managers being provided the necessary additional funding, personnel, or security expertise. Contributing to the problem is the fact that--at least in our experience--waste managers often fail to appreciate certain types of security vulnerabilities. They frequently overlook or underestimate the security risks associated with disgruntled or compromised insiders, or the potential legal and political liabilities associated with nonexistent or ineffective security. Also frequently overlooked are potential threats from waste management critics who could resort to sabotage, vandalism, or civil disobedience for purposes of discrediting a waste management program.

Johnston, R. G. (Roger G.); Garcia, A. R. E. (Anthony R. E.); Pacheco, A. N. (Adam N.); Trujillo, S. J. (Sonia J.); Martinez, R. K. (Ronald K.); Martinez, D. D. (Debbie D.); Lopez, L. N. (Leon N.)

2002-01-01T23:59:59.000Z

25

Reducing emissions to improve nuclear test detection | National Nuclear  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Reducing emissions to improve nuclear test detection | National Nuclear Reducing emissions to improve nuclear test detection | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Reducing emissions to improve nuclear test detection Reducing emissions to improve nuclear test detection Posted By Office of Public Affairs In early November, medical isotope producers met with nuclear explosion

26

Improving API Usage through Automatic Detection of Redundant Code  

E-Print Network [OSTI]

Improving API Usage through Automatic Detection of Redundant Code David Kawrykow and Martin P Programming Interfaces (APIs). We have observed many cases where APIs are used in ways that are not the most effective. We developed a technique and tool support to automatically detect such patterns of API usage

Robillard, Martin

27

The Evolving Role of MRI in the Detection and Evaluation of Breast Cancer  

Science Journals Connector (OSTI)

...-breast irradiation and adjuvant therapy. Even with this reassurance, it is likely that most women would prefer the detection of such mammographically invisible lesions so that they could be factored into decision making with regard to treatment. For this reason, a growing proportion of patients with newly... The age-adjusted rate of death from breast cancer in the United States was 24% lower in 2003 than it was in 1989,1 a decline that has been attributed principally to both the role of mammography in detecting early-stage tumors and improvements in therapy. ...

Smith R.A.

2007-03-29T23:59:59.000Z

28

Lane departure detection for improved road geometry estimation  

E-Print Network [OSTI]

vehicles is mea- sured using a vision system and a radar, whereas the shape of the road is measured using1 Lane departure detection for improved road geometry estimation Thomas B. Sch¨on Andreas Eidehall Fredrik Gustafsson Division of Automatic Control Vehicle Dynamics and Active Safety Link¨oping University

Schön, Thomas

29

Estimating distribution of the age of onset of detectable asymptomatic cancer  

E-Print Network [OSTI]

Estimating distribution of the age of onset of detectable asymptomatic cancer Giovanni Parmigiani through the Specialized Program of Research Ex­ cellence (SPORE) grant in Breast Cancer at Duke University to estimate the distribution of the age of onset of detectable preclinical cancer, using incidence data

West, Mike

30

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision  

E-Print Network [OSTI]

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision Aflatoxin B1 for risk assessment purposes Cancer Risk Assessment examines existing scientific evidence to determine the relationship between exposure to a chemical and the likelihood of developing cancer from that exposure. Text

Korhonen, Anna

31

Improving Credit Card Fraud Detection using a Meta- Classification Strategy  

E-Print Network [OSTI]

One of the issues facing credit card fraud detection systems is that a significant percentage of transactions labeled as fraudulent are in fact legitimate. These “false alarms ” delay the detection of fraudulent transactions and can cause unnecessary concerns for customers. In this study, over 1 million unique credit card transactions from 11 months of data from a large Canadian bank were analyzed. A meta-classifier model was applied to the transactions after being analyzed by the Bank’s existing neural network based fraud detection algorithm. This meta-classifier model consists of 3 base classifiers constructed using the decision tree, naïve Bayesian, and k-nearest neighbour algorithms. The naïve Bayesian algorithm was also used as the meta-level algorithm to combine the base classifier predictions to produce the final classifier. Results from the research show that when a metaclassifier was deployed in series with the Bank’s existing fraud detection algorithm improvements of up to 28 % to their existing system can be achieved.

Joseph Pun; Yuri Lawryshyn

32

Improved Measurement of Androgen Receptors in Human Breast Cancer  

Science Journals Connector (OSTI)

...1 This work was supported by the Norwegian Cancer Society (Norsk Forening til Kreftens Bekjempelse). Oscar A. Lea 2 Stener...1This work was supported by the Norwegian Cancer Society (Norsk Forcning til Kreftens Bekjempelse). - To whom requests for...

Oscar A. Lea; Stener Kvinnsland; Thor Thorsen

1989-12-15T23:59:59.000Z

33

Low-Dose Spiral CT Scans for Early Lung Cancer Detection | Department of  

Broader source: Energy.gov (indexed) [DOE]

Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999). A low-dose spiral chest CT differs from a full-dose conventional chest CT scan primarily in the amount of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense as the tissues of other organs (i.e., less x-ray radiation is needed to penetrate the lung). Radiation dose can be further reduced with lung cancer screening due to the

34

Physician-driven education to improve disparity in colorectal cancer  

Science Journals Connector (OSTI)

...Community-based Interventions: Poster Presentations - Proffered...learned from ENACCT's pilot education program Margo Michaels 1 Natasha...targeting key stakeholders. The Education Network to Advance Cancer...community-centered approaches to CCTs education. In 2006, ENACCT launched...

Timothy Woodward; Monica Albertie; Garik Nicholson; Kenneth Vega; Renard Rawls; and Gerardo Colon-Otero

2007-11-01T23:59:59.000Z

35

Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy  

E-Print Network [OSTI]

Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

Smith, Elizabeth Brooks

2009-05-15T23:59:59.000Z

36

Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer  

E-Print Network [OSTI]

Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13...

Chinna Balareddy, Karthik Reddy

2012-10-19T23:59:59.000Z

37

Algorithms for Detecting Significantly Mutated Pathways in Cancer  

E-Print Network [OSTI]

breast and colorectal cancers. Science 314(5797), 268­274 (2006) 37. Tsuda, K., Noble, W.S.: Learning.Y., Lee, E., Liu, Y.T., Lee, D., Ideker, T.: Network-based classification of breast cancer metastasis. Mol and colorectal cancers. Genome Res. 17, 1304­1318 (2007) 26. Liu, M., et al.: Network-based analysis of affected

Raphael, Ben J.

38

An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration  

E-Print Network [OSTI]

An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration J. L the success of geologic carbon sequestration projects. To detect subtle CO2 leakage signals, we present), An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration, Geophys. Res

Hilley, George

39

Improved Method for Detection of Vibrio parahaemolyticus in Seafood  

Science Journals Connector (OSTI)

...Detection of Vibrio parahaemolyticus in Seafood Yukiko Hara-Kudo Tokuhiro Nishina Hiroshi...for detecting Vibrio parahaemolyticus in seafoods using enrichment and plating onto a chromogenic...frequently from naturally contaminated seafood samples using the chromogenic agar than...

Yukiko Hara-Kudo; Tokuhiro Nishina; Hiroshi Nakagawa; Hirotaka Konuma; Junko Hasegawa; Susumu Kumagai

2001-12-01T23:59:59.000Z

40

Improvements to a queue and delay estimation algorithm utilized in video imaging vehicle detection systems  

E-Print Network [OSTI]

Video Imaging Vehicle Detection Systems (VIVDS) are steadily becoming the dominant method for the detection of vehicles at a signalized traffic approach. This research is intended to investigate the improvement of a queue and delay estimation...

Cheek, Marshall Tyler

2007-09-17T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Towards Improving the``Detection" Power of Brain Imaging Experiments Using fNIRS  

Science Journals Connector (OSTI)

To improve ``detection" power, dynamical time warping averaging algorithm is introduced for averaging the hemodynamic responses across blocks. It is applied on N-back tasks and shown...

Zhu, Li; Peifer, Maria; Najafizadeh, Laleh

42

Low-Dose Spiral CT Scans for Early Lung Cancer Detection  

Broader source: Energy.gov [DOE]

Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999).

43

Early detection of ovarian cancer using group biomarkers  

Science Journals Connector (OSTI)

...West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 2000;97:12776-81. 29 Bouchard D, Morisset D, Bourbonnais Y, Tremblay GM. Proteins with whey-acidic-protein motifs and cancer...

Alain B. Tchagang; Ahmed H. Tewfik; Melissa S. DeRycke; Keith M. Skubitz; Amy P.N. Skubitz

2008-01-01T23:59:59.000Z

44

Improving the Performance of On-Road Vehicle Detection by Combining Gabor and Wavelet  

E-Print Network [OSTI]

from gray-scale images. A first step of any vehicle detection system is hypothesizing the loca- tions1 Improving the Performance of On-Road Vehicle Detection by Combining Gabor and Wavelet Features to the problem of vehicle detection. These methods learn the characteristics of the vehicle class from a set

Bebis, George

45

An improved approach for robust road marking detection and tracking applied to multi-lane estimation.  

E-Print Network [OSTI]

provided a great number of devices on many types of automatic vehicle guidance and security systems detection system. This application is usually based on road marking detection algorithms. [3]. This systemAn improved approach for robust road marking detection and tracking applied to multi

Paris-Sud XI, Université de

46

Computerized detection of breast cancer on automated breast ultrasound imaging of women with dense breasts  

SciTech Connect (OSTI)

Purpose: Develop a computer-aided detection method and investigate its feasibility for detection of breast cancer in automated 3D ultrasound images of women with dense breasts. Methods: The HIPAA compliant study involved a dataset of volumetric ultrasound image data, “views,” acquired with an automated U-Systems Somo•V{sup ®} ABUS system for 185 asymptomatic women with dense breasts (BI-RADS Composition/Density 3 or 4). For each patient, three whole-breast views (3D image volumes) per breast were acquired. A total of 52 patients had breast cancer (61 cancers), diagnosed through any follow-up at most 365 days after the original screening mammogram. Thirty-one of these patients (32 cancers) had a screening-mammogram with a clinically assigned BI-RADS Assessment Category 1 or 2, i.e., were mammographically negative. All software used for analysis was developed in-house and involved 3 steps: (1) detection of initial tumor candidates, (2) characterization of candidates, and (3) elimination of false-positive candidates. Performance was assessed by calculating the cancer detection sensitivity as a function of the number of “marks” (detections) per view. Results: At a single mark per view, i.e., six marks per patient, the median detection sensitivity by cancer was 50.0% (16/32) ± 6% for patients with a screening mammogram-assigned BI-RADS category 1 or 2—similar to radiologists’ performance sensitivity (49.9%) for this dataset from a prior reader study—and 45.9% (28/61) ± 4% for all patients. Conclusions: Promising detection sensitivity was obtained for the computer on a 3D ultrasound dataset of women with dense breasts at a rate of false-positive detections that may be acceptable for clinical implementation.

Drukker, Karen, E-mail: kdrukker@uchicago.edu; Sennett, Charlene A.; Giger, Maryellen L. [Department of Radiology, MC2026, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)] [Department of Radiology, MC2026, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)

2014-01-15T23:59:59.000Z

47

Improved polymerase chain reaction (PCR) detection ofGaeumannomyces graminis including a safeguard against false negatives  

Science Journals Connector (OSTI)

A previously reported method for polymerase chain reaction (PCR) detection ofGaeumannomyces graminis was modified to simplify it, improve its specificity and decrease the possibility of contamination of the assay...

Elaine Ward

1995-09-01T23:59:59.000Z

48

Using Combinatorial Benchmark Construction to Improve the Assessment of Concurrency Bug Detection Tools  

E-Print Network [OSTI]

of performance measures. The inclusion of performance measures ensure that we can assess the fitnessUsing Combinatorial Benchmark Construction to Improve the Assessment of Concurrency Bug Detection, it is difficult to assess the fitness of a particular con- currency bug detection method and to compare

Bradbury, Jeremy S.

49

Comparative study of microwave tomography segmentation techniques based on GMM and KNN in breast cancer detection  

Science Journals Connector (OSTI)

Microwave Tomography Imaging (MTI) is a new technology for early breast cancer detection. Compared to other methods such as X-ray, Magnetic Resonance Imaging (MRI) and ultrasound, the MTI technology is almost radiation-free, and low cost. However, the ... Keywords: gaussian mixture model, microwave tomography imaging, segmentation

Chunqiu Wang, Wei Wang, Sung Shin, Soon I. Jeon

2014-10-01T23:59:59.000Z

50

Neutron Imaging Explored as Complementary Technique for Improving...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron Imaging Explored as Complementary Technique for Improving Cancer Detection August 05, 2013 Researcher Maria Cekanova analyzes the neutron radiographs of a canine breast...

51

Abstract 4699: Analytical validation of solid tumor fusion gene detection in a comprehensive NGS-based clinical cancer genomic test  

Science Journals Connector (OSTI)

...comprehensive NGS-based clinical cancer genomic test Roman Yelensky 1 Amy Donahue 1 Geoff Otto...alterations in all cancer genes in a single test. However, for NGS to achieve its full...validation of an NGS-based diagnostic test for accurate detection of clinically-relevant...

Roman Yelensky; Amy Donahue; Geoff Otto; Michelle Nahas; Jie He; Frank Juhn; Sean Downing; Garrett M. Frampton; Juliann Chmielecki; Jeffrey S. Ross; Maureen Zakowski; Marc Ladanyi; Vincent A. Miller; Philip J. Stephens; Doron Lipson

2014-10-01T23:59:59.000Z

52

Detection of aldehydes in lung cancer cell culture by gas chromatography/mass spectrometry and solid-phase microextraction with on-fiber derivatization  

E-Print Network [OSTI]

of lung cancer. 2-4 A high level of aldehydes was found both in breath and blood of lung cancer patients. Acrolein was detected in blood from patients with breast cancer. 5 The formaldehyde level from women with breast cancer was higher than...

Shan, Guangqing

2007-09-17T23:59:59.000Z

53

Improved methods for detecting gravitational waves associated with short gamma-ray bursts  

E-Print Network [OSTI]

In the era of second generation ground-based gravitational wave detectors, short gamma-ray bursts (GRBs) will be among the most promising astrophysical events for joint electromagnetic and gravitational wave observation. A targeted search for gravitational wave compact binary merger signals in coincidence with short GRBs was developed and used to analyze data from the first generation LIGO and Virgo instruments. In this paper, we present improvements to this search that enhance our ability to detect gravitational wave counterparts to short GRBs. Specifically, we introduce an improved method for estimating the gravitational wave background to obtain the event significance required to make detections; implement a method of tiling extended sky regions, as required when searching for signals associated to poorly localized GRBs from Fermi Gamma-ray Burst Monitor or the InterPlanetary Network; and incorporate astrophysical knowledge about the beaming of GRB emission to restrict the search parameter space. We descri...

Williamson, A R; Fairhurst, S; Harry, I W; Macdonald, E; Macleod, D; Predoi, V

2014-01-01T23:59:59.000Z

54

Breast Cancer Research Finding Answers. Finding Cures.  

E-Print Network [OSTI]

Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

Kowalczykowski, Stephen C.

55

Improved methods for detecting gravitational waves associated with short gamma-ray bursts  

E-Print Network [OSTI]

In the era of second generation ground-based gravitational wave detectors, short gamma-ray bursts (GRBs) will be among the most promising astrophysical events for joint electromagnetic and gravitational wave observation. A targeted search for gravitational wave compact binary merger signals in coincidence with short GRBs was developed and used to analyze data from the first generation LIGO and Virgo instruments. In this paper, we present improvements to this search that enhance our ability to detect gravitational wave counterparts to short GRBs. Specifically, we introduce an improved method for estimating the gravitational wave background to obtain the event significance required to make detections; implement a method of tiling extended sky regions, as required when searching for signals associated to poorly localized GRBs from Fermi Gamma-ray Burst Monitor or the InterPlanetary Network; and incorporate astrophysical knowledge about the beaming of GRB emission to restrict the search parameter space. We describe the implementation of these enhancements and demonstrate how they improve the ability to observe binary merger gravitational wave signals associated with short GRBs.

A. R. Williamson; C. Biwer; S. Fairhurst; I. W. Harry; E. Macdonald; D. Macleod; V. Predoi

2014-10-22T23:59:59.000Z

56

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure  

Science Journals Connector (OSTI)

AbstractBackground Next generation sequencing (NGS) allows the detection of minor variant HIV drug resistance mutations (DRMs). However data from new NGS platforms after Prevention-of-Mother-to-Child-Transmission (PMTCT) regimen failure are limited. Objective To compare major and minor variant HIV \\{DRMs\\} with Illumina MiSeq and Life Technologies Ion Personal Genome Machine (PGM) in infants infected despite a PMTCT regimen. Study design We conducted a cross-sectional study of NGS for detecting \\{DRMs\\} in infants infected despite a zidovudine (AZT) and Nevirapine (NVP) regimen, before initiation of combination antiretroviral therapy. Sequencing was performed on PCR products from plasma samples on PGM and MiSeq platforms. Bioinformatic analyses were undertaken using a codon-aware version of the Smith–Waterman mapping algorithm and a mixture multinomial error filtering statistical model. Results Of 15 infants, tested at a median age of 3.4 months after birth, 2 (13%) had non-nucleoside reverse transcriptase inhibitor (NNRTI) \\{DRMs\\} (K103N and Y181C) by bulk sequencing, whereas PGM detected 4 (26%) and MiSeq 5 (30%). NGS enabled the detection of additional minor variant \\{DRMs\\} in the infant with K103N. Coverage and instrument quality scores were higher with MiSeq, increasing the confidence of minor variant calls. Conclusions NGS followed by bioinformatic analyses detected multiple minor variant \\{DRMs\\} in HIV-1 RT among infants where PMTCT failed. The high coverage of MiSeq and high read quality improved the confidence of identified \\{DRMs\\} and may make this platform ideal for minor variant detection.

Randall G. Fisher; Davey M. Smith; Ben Murrell; Ruhan Slabbert; Bronwyn M. Kirby; Clair Edson; Mark F. Cotton; Richard H. Haubrich; Sergei L. Kosakovsky Pond; Gert U. Van Zyl

2015-01-01T23:59:59.000Z

57

IMPROVED THEORETICAL PREDICTIONS OF MICROLENSING RATES FOR THE DETECTION OF PRIMORDIAL BLACK HOLE DARK MATTER  

SciTech Connect (OSTI)

Primordial black holes (PBHs) remain a dark matter (DM) candidate of the Standard Model of Particle Physics. Previously, we proposed a new method of constraining the remaining PBH DM mass range using microlensing of stars monitored by NASA's Kepler mission. We improve this analysis using a more accurate treatment of the population of the Kepler source stars, their variability, and limb darkening. We extend the theoretically detectable PBH DM mass range down to 2 Multiplication-Sign 10{sup -10} M{sub Sun }, two orders of magnitude below current limits and one-third order of magnitude below our previous estimate. We address how to extract the DM properties, such as mass and spatial distribution, if PBH microlensing events were detected. We correct an error in a well-known finite-source limb-darkening microlensing formula and also examine the effects of varying the light curve cadence on PBH DM detectability. We also introduce an approximation for estimating the predicted rate of detection per star as a function of the star's properties, thus allowing for selection of source stars in future missions, and extend our analysis to planned surveys, such as the Wide-Field Infrared Survey Telescope.

Cieplak, Agnieszka M.; Griest, Kim [Department of Physics, University of California, San Diego, CA 92093 (United States)

2013-04-20T23:59:59.000Z

58

Nanotechnology Alert. Nanofountain for Treatment of Cancer; Nanocomposites To Improve Computers' Life Span; Lithium Sulfur Batteries Using Nanocarbon  

E-Print Network [OSTI]

Nanotechnology Alert. Nanofountain for Treatment of Cancer; Nanocomposites To Improve Computers/29/2009 Nanotechnology Alert. Nanofountain f... frost.com/.../market-service-segment... 1/2 #12;Learn how we can provide/29/2009 Nanotechnology Alert. Nanofountain f... frost.com/.../market-service-segment... 2/2 #12;

Espinosa, Horacio D.

59

Fault-tolerant control for current sensors of doubly fed induction generators based on an improved fault detection method  

Science Journals Connector (OSTI)

Abstract Fault-tolerant control of current sensors is studied in this paper to improve the reliability of a doubly fed induction generator (DFIG). A fault-tolerant control system of current sensors is presented for the DFIG, which consists of a new current observer and an improved current sensor fault detection algorithm. The current observer is constructed by using only voltage signals as inputs. The fault detection algorithm is based on the current observer, in which an adaptive threshold and different fault duration times are considered. The performance of the proposed observer, improved fault detection algorithm, and fault-tolerant control system are investigated by simulation. The results indicate that the outputs of the observer and the sensor are highly coherent. The fault detection algorithm can efficiently detect both soft and hard faults in current sensors, and the fault-tolerant control system can effectively tolerate both types of faults.

H. Li; C. Yang; Y.G. Hu; B. Zhao; M. Zhao; Z. Chen

2014-01-01T23:59:59.000Z

60

Improvement of the detection limit for biosensors: Advances on the optimization of biocomposite composition  

Science Journals Connector (OSTI)

Abstract In this work the application of advanced characterization techniques in the development of amperometric biosensors based on biocomposites is described. The optimization of the conductive particle distribution and the amount of the biological material inside the biomaterial have allowed an improvement of the electrochemical properties, regarding the electroanalytical properties such as signal stability and limit of detection. The high signal-to-noise ratio obtained in the electrochemical transduction has allowed enhancing the limit of detection of the biosensor. In the present study, it has been demonstrated the feasibility of electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) for the characterization and optimization of biosensors based on graphite–epoxy–enzyme, using an enzyme model. The optimum biocomposite proportion based on graphite–epoxy which incorporates the enzyme glucose oxidase (GOD) on the matrix ranges between 16% and 17% of graphite using 1% and 2% of enzyme. This range provides the optimal electroanalytical properties. Low limit of detection and good sensitivity have been achieved. Furthermore, confocal laser scanning microscopy was used to visualize the enzyme distribution onto the surface electrode.

R. Montes; J. Bartrolí; M. Baeza; F. Céspedes

2015-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer  

SciTech Connect (OSTI)

We previously demonstrated the efficacy of BNCT mediated by boronophenylalanine (BPA) to treat tumors in a hamster cheek pouch model of oral cancer with no normal tissue radiotoxicity and moderate, albeit reversible, mucositis in precancerous tissue around treated tumors. It is known that boron targeting of the largest possible proportion of tumor cells contributes to the success of BNCT and that tumor blood vessel normalization improves drug delivery to the tumor. Within this context, the aim of the present study was to evaluate the effect of blood vessel normalization on the therapeutic efficacy and potential radiotoxicity of BNCT in the hamster cheek pouch model of oral cancer.

D. W. Nigg

2012-01-01T23:59:59.000Z

62

Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors  

E-Print Network [OSTI]

the cardiorespiratory fitness (VO2max) level and body composition (weight, BMI, % body fat) in breast cancer survivors. We reported that breast cancer survivors had a low VO2max compared to normal values in a healthy population. In addition, submaximal VO2 exercise...

Burnett, Dave

2013-05-31T23:59:59.000Z

63

Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)  

SciTech Connect (OSTI)

The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

Larson, S.M.; Finn, R.D.

1990-10-15T23:59:59.000Z

64

Artificial Neural Network-Based Serum Biomarkers Analysis Improves Sensitivity in the Diagnosis of Lung Cancer  

Science Journals Connector (OSTI)

Lung cancer diagnosis in early stages could be of paramount interest since patients may be treated opportunely decreasing the high death rate caused by this disease. A biomarker may describe abnormalities in the ...

J. M. Flores; E. Herrera; G. Leal…

2013-01-01T23:59:59.000Z

65

Dose critical in-vivo detection of anti-cancer drug levels in blood  

DOE Patents [OSTI]

A method and apparatus are disclosed for the in vivo and in vitro detection and measurement of dose critical levels of DNA-binding anti-cancer drug levels in biological fluids. The apparatus comprises a laser based fiber optic sensor (optrode) which utilizes the secondary interactions between the drug and an intercalating fluorochrome bound to a probe DNA, which in turn is attached to the fiber tip at one end thereof. The other end of the optical fiber is attached to an illumination source, detector and recorder. The fluorescence intensity is measured as a function of the drug concentration and its binding constant to the probe DNA. Anticancer drugs which lend themselves to analysis by the use of the method and the optrode of the present invention include doxorubicin, daunorubicin, carminomycin, aclacinomycin, chlorambucil, cyclophosphamide, methotrexate, 5-uracil, arabinosyl cytosine, mitomycin, cis-platinum 11 diamine dichloride procarbazine, vinblastine vincristine and the like. The present method and device are suitable for the continuous monitoring of the levels of these and other anticancer drugs in biological fluids such as blood, serum, urine and the like. The optrode of the instant invention also enables the measurement of the levels of these drugs from a remote location and from multiple samples.

Miller, Holly H. (Bethel Island, CA); Hirschfeld, deceased, Tomas B. (late of Livermore, CA)

1991-01-01T23:59:59.000Z

66

A Framework for Improving the Quality of Cancer Care: The Case of Breast and Cervical Cancer Screening  

Science Journals Connector (OSTI)

...Data sources include review of relevant literature...levels (community, plan and practice setting...procedures. Recent reviews have underscored...the seven DETECT plans, the range and variation...Data sources include review of relevant literature...levels (community, plan and practice setting...

Jane G. Zapka; Stephen H. Taplin; Leif I. Solberg; and M. Michele Manos

2003-01-01T23:59:59.000Z

67

Improvement of automatic man-made object detection in underwater videos by using of navigational information  

E-Print Network [OSTI]

objects thanks to the calculation of the sun position in relation to the vehicle position, the detection is generally addressed using a system with four steps: a detection step, a classification step mission, detection and guidance are done by sonar. When the vehicle is close to the mine, the video camera

Paris-Sud XI, Université de

68

Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care  

E-Print Network [OSTI]

Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker.e., a cell phone/charge-coupled device (CCD) to quantify an ovarian cancer biomarker, HE4, in urine. Integration of a mobile application with a cell phone enabled immediate processing of microchip ELISA results

Demirci, Utkan

69

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

70

Improved Recurrence-Free Survival with ARCON for Anemic Patients with Laryngeal Cancer  

Science Journals Connector (OSTI)

...Cancer Geert O. Janssens 1 Saskia E. Rademakers 1 Chris H. Terhaard 3 Patricia A...analysis): G.O. Janssens, S.E. Rademakers, I.J. Hoogsteen, P.N. Span...manuscript: G.O. Janssens, S.E. Rademakers, C.H. Terhaard, P.A. Doornaert...

Geert O. Janssens; Saskia E. Rademakers; Chris H. Terhaard; Patricia A. Doornaert; Hendrik P. Bijl; Piet van den Ende; Alim Chin; Robert P. Takes; Remco de Bree; Ilse J. Hoogsteen; Johan Bussink; Paul N. Span; Johannes H. Kaanders

2014-03-01T23:59:59.000Z

71

Improving the detectability of gravitational wave counterparts of short hard gamma ray bursts .  

E-Print Network [OSTI]

??With multiple observatories and missions being planned for detecting orphaned afterglows associated with gamma-ray bursts (GRBs) we emphasize the importance of developing data analysis strategies… (more)

[No author

2013-01-01T23:59:59.000Z

72

Improved  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Improved Improved cache performance in Monte Carlo transport calculations using energy banding A. Siegel a , K. Smith b , K. Felker c,∗ , P . Romano b , B. Forget b , P . Beckman c a Argonne National Laboratory, Theory and Computing Sciences and Nuclear Engineering Division b Massachusetts Institute of Technology, Department of Nuclear Science and Engineering c Argonne National Laboratory, Theory and Computing Sciences Abstract We present an energy banding algorithm for Monte Carlo (MC) neutral parti- cle transport simulations which depend on large cross section lookup tables. In MC codes, read-only cross section data tables are accessed frequently, ex- hibit poor locality, and are typically much too large to fit in fast memory. Thus, performance is often limited by long latencies to RAM, or by off-node communication latencies when the data footprint is very large and must be decomposed on

73

Postoperative Radiotherapy for Lung Cancer: Improvement in Locoregional Control Using Three-Dimensional Compared With Two-Dimensional Technique  

SciTech Connect (OSTI)

Purpose: To determine whether lung cancer patients treated with three-dimensional (3D) postoperative radiotherapy (PORT) have more favorable outcomes than those treated with two-dimensional (2D) PORT. Patients and Methods: We retrospectively analyzed the charts of 153 lung cancer patients who underwent PORT with curative intent at our center between 1995 and 2007. The patients were grouped according to the RT technique; 66 patients were in the 2D group and 87 in the 3D group. The outcomes included locoregional control, survival, and secondary effects. All patients were treated using a linear accelerator at a total dose of approximately 50 Gy and 2 Gy/fraction. A few patients (21%) also received chemotherapy. Most tumors were in the advanced stage, either Stage II (30%) or Stage III (65%). The main clinical indications for PORT were positive resection margins (23%) and Stage pN2 (52%) and pN1 (22%). The patient characteristics were comparable in both groups. Results: Kaplan-Meier analysis showed that the 3D technique significantly improved the locoregional control rate at 5 years compared with the 2D technique (81% vs. 56%, p = .007 [Cox]). The 2D technique was associated with a more than twofold increased risk of locoregional recurrence (hazard ratio, 2.7; 95% confidence interval, 1.3-5.5; p = .006). The overall survival rate did not differ at 5 years (38% vs. 20%, p = .3 [Cox]). The toxicities were also similar and acceptable in both groups. Conclusion: The 3D technique for conformal PORT for lung cancer improved the locoregional control rates of patients compared with the 2D technique.

Masson-Cote, Laurence [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada); Couture, Christian [Departments of Anatomic Pathology and Cytology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec (Hopital Laval), Quebec City, QC (Canada); Fortin, Andre [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada); Dagnault, Anne, E-mail: anne.dagnault@mail.chuq.qc.ca [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-L'Hotel-Dieu de Quebec, Quebec City, QC (Canada)

2011-07-01T23:59:59.000Z

74

The Antibody Response to Tumor Inoculation Improved Methods of Antibody Detection  

Science Journals Connector (OSTI)

...Methods of Antibody Detection P. A. Gorer Z. B...the saline used as a vehicle for the dilution of...in routine use as a vehicle for antibody dilution...the efficiency of any system. Technical failures...methods of antibody detection. | Journal Article...

P. A. Gorer and Z. B. Mikulska

1954-10-01T23:59:59.000Z

75

IMPROVEMENT OF AUTOMATIC MAN-MADE OBJECT DETECTION IN UNDERWATER VIDEOS BY USING OF  

E-Print Network [OSTI]

to the calculation of the sun position in relation to the vehicle position, the detection with the distance from- dressed using a system with four steps: a detection step, a classification step, an identification step, and a neutralization step [1]. Nowadays, the trend is to de- sign autonomous systems (Autonomous underwater vehicles

Paris-Sud XI, Université de

76

Method of detecting cancer in a single cell using mitochondrial correlation microscopy  

DOE Patents [OSTI]

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L

2013-06-25T23:59:59.000Z

77

Method for detecting cancer in a single cell using mitochondrial correlation microscopy  

DOE Patents [OSTI]

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L. (Albuquerque, NM)

2012-03-06T23:59:59.000Z

78

Estimated Mean Sojourn Time Associated with Hemoccult SENSA for Detection of Proximal and Distal Colorectal Cancer  

Science Journals Connector (OSTI)

...Transition time between these states is modeled with an exponential distribution (e.g., time from preclinical to clinical...prediction for cancer screening models using deconvolution and smoothing.Biometrics 2001;57:389-95. 8. Jouve JL , Remontet...

Wenying Zheng and Carolyn M. Rutter

2012-10-01T23:59:59.000Z

79

784 IEEE TRANSACTIONS ON SYSTEMS, MAN, AND CYBERNETICS--PART C: APPLICATIONS AND REVIEWS, VOL. 36, NO. 6, NOVEMBER 2006 Improving Weapon Detection in Single Energy  

E-Print Network [OSTI]

, NO. 6, NOVEMBER 2006 Improving Weapon Detection in Single Energy X-Ray Images Through Pseudocoloring, particularly hard to see low-density weapons in luggage. Considerations of the psychological and physiological performing color schemes. Rate improvements in weapon detection of up to 97% were achieved through the use

Abidi, Mongi A.

80

Frequency and Clinical Significance of Previously Undetected Incidental Findings Detected on Computed Tomography Simulation Scans for Breast Cancer Patients  

SciTech Connect (OSTI)

Purpose: To determine the frequency and clinical significance of previously undetected incidental findings found on computed tomography (CT) simulation images for breast cancer patients. Methods and Materials: All CT simulation images were first interpreted prospectively by radiation oncologists and then double-checked by diagnostic radiologists. The official reports of CT simulation images for 881 consecutive postoperative breast cancer patients from 2009 to 2010 were retrospectively reviewed. Potentially important incidental findings (PIIFs) were defined as any previously undetected benign or malignancy-related findings requiring further medical follow-up or investigation. For all patients in whom a PIIF was detected, we reviewed the clinical records to determine the clinical significance of the PIIF. If the findings from the additional studies prompted by a PIIF required a change in management, the PIIF was also recorded as a clinically important incidental finding (CIIF). Results: There were a total of 57 (6%) PIIFs. The 57 patients in whom a PIIF was detected were followed for a median of 17 months (range, 3-26). Six cases of CIIFs (0.7% of total) were detected. Of the six CIIFs, three (50%) cases had not been noted by the radiation oncologist until the diagnostic radiologist detected the finding. On multivariate analysis, previous CT examination was an independent predictor for PIIF (p = 0.04). Patients who had not previously received chest CT examinations within 1 year had a statistically significantly higher risk of PIIF than those who had received CT examinations within 6 months (odds ratio, 3.54; 95% confidence interval, 1.32-9.50; p = 0.01). Conclusions: The rate of incidental findings prompting a change in management was low. However, radiation oncologists appear to have some difficulty in detecting incidental findings that require a change in management. Considering cost, it may be reasonable that routine interpretations are given to those who have not received previous chest CT examinations within 1 year.

Nakamura, Naoki, E-mail: naokinak@luke.or.jp [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan)] [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan); Tsunoda, Hiroko [Department of Radiology, St. Luke's International Hospital, Tokyo (Japan)] [Department of Radiology, St. Luke's International Hospital, Tokyo (Japan); Takahashi, Osamu [Division of General Internal Medicine, Department of Medicine, St. Luke's International Hospital, Tokyo (Japan)] [Division of General Internal Medicine, Department of Medicine, St. Luke's International Hospital, Tokyo (Japan); Kikuchi, Mari; Honda, Satoshi [Department of Radiology, St. Luke's International Hospital, Tokyo (Japan)] [Department of Radiology, St. Luke's International Hospital, Tokyo (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan)] [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan); Akahane, Keiko; Sekiguchi, Kenji [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan)] [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan)

2012-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Detecting nuclear materials smuggling: using radiography to improve container inspection policies  

Science Journals Connector (OSTI)

This paper proposes a layered container inspection system for detecting illicit nuclear materials using radiography information. We argue that the current inspection system, relying heavily on the Automated Ta...

Gary M. Gaukler; Chenhua Li; Rory Cannaday…

2011-07-01T23:59:59.000Z

82

Novel Pattern Recognition Techniques for Improved Target Detection in Hyperspectral Imagery  

E-Print Network [OSTI]

........................ 7 C. Spatial Domain Versus Spectral Domain .................................. 9 D. The HSI Data Cube ................................................................... 10 E. Classification Versus Detection... Page 1 General concept of hyperspectral imaging................................................. 7 2 Construction of a typical hyperspectral image........................................... 9 3 Data cube visualization showing spatial...

Sakla, Wesam Adel

2011-02-22T23:59:59.000Z

83

Probability of Cancer in Pulmonary Nodules Detected on First Screening CT  

Science Journals Connector (OSTI)

...nodules; one-sided 97.5% CI, 0 to 0.006). The location of a nodule was evaluated according to lobar distribution. A larger number of nodules and a larger number of cancers were observed in the left upper and right upper lobes than in the left or right lower lobes or the right middle lobe (Table 1). For... Using data from two large data sets of lung-cancer screening by CT, the authors identified factors that increased the likelihood that a nodule was malignant, including older age, female sex, nodule location in the upper lobe, lower nodule count, and certain nodule features.

McWilliams A.; Tammemagi M.C.; Mayo J.R.

2013-09-05T23:59:59.000Z

84

Effectiveness of a clinical intervention in improving pain control in outpatients with cancer treated by radiation therapy  

SciTech Connect (OSTI)

Purpose: To determine the effectiveness of a multicomponent clinical intervention to reduce pain in outpatients with cancer. Methods and Materials: Sixty-four patients were randomly assigned to receive either a clinical intervention including an information session, the use of a pain diary, and the possibility to contact a physician to adjust the pain medication, or the usual treatment of pain by the staff radiation oncologist. All patients reported their average and worst pain levels at baseline and 2 and 3 weeks after the start of the intervention. Results: The study groups were similar with respect to their baseline characteristics and pain levels at randomization. After 3 weeks, the average and worst pain experienced by patients randomized to the clinical intervention group was significantly inferior to the average pain experienced by patients in the control group (2.9/10 vs. 4.4/10 and 4.2/10 vs. 5.5/10, respectively). Results showed that the experimental group patients decreased their pain levels more than the control group patients did over time. Conclusion: An intervention including patient education, a pain diary, and defining a procedure for therapeutic adjustments can be effective to improve pain relief in outpatients with cancer.

Vallieres, Isabelle [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-Hotel-Dieu de Quebec, Quebec City (Canada)]. E-mail: isabelle.vallieres@mail.chuq.qc.ca; Aubin, Michele [Department of Family Medicine, Laval Hospital, Quebec City, Quebec (Canada); Blondeau, Lucie [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-Hotel-Dieu de Quebec, Quebec City (Canada); Simard, Serge [Research Centre of Laval Hospital, Laval University, Sainte-Foy, Quebec (Canada); Giguere, Anik [Palliative Care Research Team, Laval University, Quebec City, Quebec (Canada)

2006-09-01T23:59:59.000Z

85

Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including early detection of cancers  

DOE Patents [OSTI]

An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of CEA is described including injecting a possible CEA-containing sample into a sensor cell including the assay element, maintaining the sample within the sensor cell for time sufficient for binding to occur between CEA present within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.

Martinez, Jennifer S. (Santa Fe, NM); Swanson, Basil I. (Los Alamos, NM); Shively, John E. (Arcadia, CA); Li, Lin (Monrovia, CA)

2009-06-02T23:59:59.000Z

86

Identification of Circulating MicroRNA Signatures for Breast Cancer Detection  

Science Journals Connector (OSTI)

...early-stage disease have motivated an active search for diagnostic biomarkers for breast cancer...SDS files) downloaded from Exiqon's website. The Gene Expression Omnibus accession...31:38. 38. Pigati L , Yaddanapudi SC, Iyengar R, Kim DJ, Hearn SA, Danforth...

Maurice Chan; Chiew Suan Liaw; Shen Mo Ji; Hwee Huang Tan; Chow Yin Wong; Aye Aye Thike; Puay Hoon Tan; Gay Hui Ho; and Ann Siew-Gek Lee

2013-08-15T23:59:59.000Z

87

Improved backscatter x-ray detection for anti-terrorist applications  

SciTech Connect (OSTI)

Currently the most common method to determine the contents of a package suspected of containing an explosive device is to use transmission radiography. This technique requires that an x-ray source and film be placed on opposite sides of the package. This poses a problem if the package is placed so that only one side is accessible, such as against a wall. There is also a threat to personnel and property since explosive devices may be booby trapped. The authors have developed a method to x-ray a package using backscattered x-rays based on similar work for landmine detection. This procedure eliminates the use of film behind the target. All of the detection is done from the same side as the source. Backscatter experiments at Sandia National Laboratories have been conducted on mock bombs in packages. They are able to readily identify the bomb components. The images that are obtained in this procedure are done in real time and the image is displayed on a computer screen. Preliminary experiments have also imaged objects within or behind a wall. They are currently using a scanning x-ray source and scintillating plastic detectors. It can take several hours to image a briefcase size object. This time could be reduced if better x-ray detection methods could be used. They have looked at using pinhole photography and CCD cameras to reduce this time.

Shope, S.L.; Lockwood, G.J.; Selph, M.M.; Wehlburg, J.C.

1999-12-01T23:59:59.000Z

88

Detection of Early Prostate Cancer Using a Hepsin-Targeted Imaging Agent  

Science Journals Connector (OSTI)

...IPL-F and either anti-HPN antibody or vehicle for 1 h at 37C, washed, detached...To determine the size limit of tumor detection, mice bearing different sizes of LNCaP-derived...clinical question especially for early detection of tumors is determining the smallest...

Kimberly A. Kelly; Sunita R. Setlur; Robert Ross; Rajesh Anbazhagan; Peter Waterman; Mark A. Rubin; and Ralph Weissleder

2008-04-01T23:59:59.000Z

89

Method for improved selectivity in photo-activation and detection of molecular diagnostic agents  

DOE Patents [OSTI]

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

Wachter, Eric A. (Oak Ridge, TN); Fisher, Walter G. (Knoxville, TN); Dees, H. Craig (Knoxville, TN)

1998-01-01T23:59:59.000Z

90

Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents  

SciTech Connect (OSTI)

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

Wachter, Eric A. (Oak Ridge, TN); Fisher, Walter G. (Knoxville, TN); Dees, H. Craig (Knoxville, TN)

2008-03-18T23:59:59.000Z

91

Control over structure-specific flexibility improves anatomical accuracy for point-based deformable registration in bladder cancer radiotherapy  

SciTech Connect (OSTI)

Purpose: Future developments in image guided adaptive radiotherapy (IGART) for bladder cancer require accurate deformable image registration techniques for the precise assessment of tumor and bladder motion and deformation that occur as a result of large bladder volume changes during the course of radiotherapy treatment. The aim was to employ an extended version of a point-based deformable registration algorithm that allows control over tissue-specific flexibility in combination with the authors' unique patient dataset, in order to overcome two major challenges of bladder cancer registration, i.e., the difficulty in accounting for the difference in flexibility between the bladder wall and tumor and the lack of visible anatomical landmarks for validation. Methods: The registration algorithm used in the current study is an extension of the symmetric-thin plate splines-robust point matching (S-TPS-RPM) algorithm, a symmetric feature-based registration method. The S-TPS-RPM algorithm has been previously extended to allow control over the degree of flexibility of different structures via a weight parameter. The extended weighted S-TPS-RPM algorithm was tested and validated on CT data (planning- and four to five repeat-CTs) of five urinary bladder cancer patients who received lipiodol injections before radiotherapy. The performance of the weighted S-TPS-RPM method, applied to bladder and tumor structures simultaneously, was compared with a previous version of the S-TPS-RPM algorithm applied to bladder wall structure alone and with a simultaneous nonweighted S-TPS-RPM registration of the bladder and tumor structures. Performance was assessed in terms of anatomical and geometric accuracy. The anatomical accuracy was calculated as the residual distance error (RDE) of the lipiodol markers and the geometric accuracy was determined by the surface distance, surface coverage, and inverse consistency errors. Optimal parameter values for the flexibility and bladder weight parameters were determined for the weighted S-TPS-RPM. Results: The weighted S-TPS-RPM registration algorithm with optimal parameters significantly improved the anatomical accuracy as compared to S-TPS-RPM registration of the bladder alone and reduced the range of the anatomical errors by half as compared with the simultaneous nonweighted S-TPS-RPM registration of the bladder and tumor structures. The weighted algorithm reduced the RDE range of lipiodol markers from 0.9-14 mm after rigid bone match to 0.9-4.0 mm, compared to a range of 1.1-9.1 mm with S-TPS-RPM of bladder alone and 0.9-9.4 mm for simultaneous nonweighted registration. All registration methods resulted in good geometric accuracy on the bladder; average error values were all below 1.2 mm. Conclusions: The weighted S-TPS-RPM registration algorithm with additional weight parameter allowed indirect control over structure-specific flexibility in multistructure registrations of bladder and bladder tumor, enabling anatomically coherent registrations. The availability of an anatomically validated deformable registration method opens up the horizon for improvements in IGART for bladder cancer.

Wognum, S.; Chai, X.; Hulshof, M. C. C. M.; Bel, A. [Department of Radiotherapy, Academic Medical Center, Meiberdreef 9, 1105 AZ Amsterdam (Netherlands); Bondar, L.; Zolnay, A. G.; Hoogeman, M. S. [Department of Radiation Oncology, Daniel den Hoed Cancer Center, Erasmus Medical Center, Groene Hilledijk 301, 3075 EA Rotterdam (Netherlands)

2013-02-15T23:59:59.000Z

92

Wavelet technique based islanding detection and improved repetitive current control for reliable operation of grid-connected PV systems  

Science Journals Connector (OSTI)

Abstract Recent years have witnessed a thrust towards the use of solar energy as the major renewable energy source for distributed power generation. The proposed system requires reliable detection technique and suitable current control strategy for proper operation. This paper focuses on plug-in repetitive current (RC) control strategy for grid connected inverter system and wavelet technique for electrical grid status identification. The performance of proposed current control technique employed for grid connected inverter system under distorted and unbalanced grid voltage is compared with the existing conventional methods like PI and PR controller. This controller uses the feedback control system for attenuating periodic disturbances, improving high quality sinusoidal output current and high power factor. The proposed scheme employs fourth order infinite impulse response (IIR) filter for maintaining its resonance frequency, output frequency matching with grid fundamental frequency and reduction of harmonics. The DC-DC boost converter implements incremental conductance based (INC) maximum power point tracker (MPPT) algorithm. The effects of LCL filter for improving disturbance rejection capability and dynamic performance of the proposed system is also demonstrated. Grid connected PV inverter employs wavelet technique for an islanding detection functionality in order to determine the status of the electrical grid. In order to show the effectiveness of the proposed algorithm, modeling and simulation for grid connected PV system is performed using MATLAB/SIMULINK and its PowerSim toolbox.

Smitha Joyce Pinto; Gayadhar Panda

2015-01-01T23:59:59.000Z

93

Investigation of Low-Cloud Characteristics Using Mesoscale Numerical Model Data for Improvement of Fog-Detection Performance by Satellite Remote Sensing  

Science Journals Connector (OSTI)

The comprehensive relationship between meteorological conditions and whether low water cloud touches the surface, particularly at sea, is examined with the goal of improving low-cloud detection by satellite. Gridpoint-value data provided by an ...

Haruma Ishida; Kentaro Miura; Teruaki Matsuda; Kakuji Ogawara; Azumi Goto; Kuniaki Matsuura; Yoshiko Sato; Takashi Y. Nakajima

2014-10-01T23:59:59.000Z

94

Multiplexed Immunobead-Based Cytokine Profiling for Early Detection of Ovarian Cancer  

Science Journals Connector (OSTI)

...quality control procedures. Thus, it...biospecimen handling issues intersect...improve specimen handling and testing procedures (2). Similar...Molecular Analysis Technologies (IMAT) Program...innovative and applied emerging technologies...

Elieser Gorelik; Douglas P. Landsittel; Adele M. Marrangoni; Francesmary Modugno; Lyudmila Velikokhatnaya; Matthew T. Winans; William L. Bigbee; Ronald B. Herberman; and Anna E. Lokshin

2005-04-01T23:59:59.000Z

95

Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer  

Science Journals Connector (OSTI)

...system was then validated in an independent test set (n = 153; AUC = 0.808). No significant...have shown that the fecal occult blood test (FOBT) is a highly cost-effective screening...immunochemical FOBT (iFOBT or Fecal Immunochemical Test, FIT) has been improved (2, 3 ) and...

Taku Harada; Eiichiro Yamamoto; Hiro-o Yamano; Masanori Nojima; Reo Maruyama; Kohei Kumegawa; Masami Ashida; Kenjiro Yoshikawa; Tomoaki Kimura; Eiji Harada; Ryo Takagi; Yoshihito Tanaka; Hironori Aoki; Masayo Nishizono; Michiko Nakaoka; Akihiro Tsuyada; Takeshi Niinuma; Masahiro Kai; Kazuya Shimoda; Yasuhisa Shinomura; Tamotsu Sugai; Kohzoh Imai; Hiromu Suzuki

2014-10-01T23:59:59.000Z

96

Abstract 4211: Detection and quantification of minoritary subclones of KRAS in metastatic colorectal cancers by digital microfluidics: therapeutic implications.  

Science Journals Connector (OSTI)

...metastatic colorectal cancers by digital microfluidics: therapeutic implications. Deniz...analyzed by multiplex droplet-based microfluidics. This method, by segregating individual...metastatic colorectal cancers by digital microfluidics: therapeutic implications. [abstract...

Deniz Pekin; Corinne Normand; Steve Kotsopoulos; Li Xinyu; Leonor Benhaim; O. Bouche; T. Lecomte; D. Le Corre; T. Hor; Z. El Harrak; P. Nizard; D. LINK; B. HUTCHISON; P. LAURENT-PUIG; Valerie Taly

2013-04-15T23:59:59.000Z

97

Acute Radiation Effects on Cardiac Function Detected by Strain Rate Imaging in Breast Cancer Patients  

SciTech Connect (OSTI)

Purpose: To investigate the occurrence of early radiation-induced changes in regional cardiac function using strain rate imaging (SRI) by tissue Doppler echocardiography. Methods and Materials: We included 20 left-sided and 10 right-sided breast cancer patients receiving radiotherapy (RT) to the breast or chest wall. Standard echocardiography and SRI were performed before RT (baseline), immediately after RT (post-RT), and at 2 months follow-up (FUP) after RT. Regional strain (S) and strain rate (SR) values were obtained from all 18 left ventricular (LV) segments. Data were compared to the regional radiation dose. Results: A reduction in S was observed post-RT and at FUP in left-sided patients (S{sub post-RT}: -17.6 {+-} 1.5%, and S{sub FUP}: -17.4 {+-} 2.3%, vs. S{sub baseline}: -19.5 {+-} 2.1%, p < 0.001) but not in right-sided patients. Within the left-sided patient group, S and SR were significantly reduced after RT in apical LV segments (S{sub post-RT}: -15.3 {+-} 2.5%, and S{sub FUP}: -14.3 {+-} 3.7%, vs. S{sub baseline}: -19.3 {+-} 3.0%, p < 0.01; and SR{sub post-RT}: -1.06 {+-} 0.15 s {sup -1}, and SR{sub FUP}: -1.16 {+-} 0.28 s {sup -1}, vs. SR{sub baseline}: -1.29 {+-} 0.27s {sup -1}, p = 0.01), but not in mid- or basal segments. Furthermore, we observed that segments exposed to more than 3 Gy showed a significant decrease in S after RT (S{sub post-RT}: -16.1 {+-} 1.6%, and S{sub FUP}: -15.8 {+-} 3.4%, vs. S{sub baseline}: -18.9 {+-} 2.6%, p < 0.001). This could not be observed in segments receiving less than 3 Gy. Conclusions: SRI shows a dose-related regional decrease in myocardial function after RT. It might be a useful tool in the evaluation of modern RT techniques, with respect to cardiac toxicity.

Erven, Katrien, E-mail: Katrien.erven@uzleuven.b [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium); Jurcut, Ruxandra [Department of Cardiology, Institute of Emergency for Cardiovascular Diseases, UMF Carol Davila, Bucharest (Romania); Weltens, Caroline [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium); Giusca, Sorin [Department of Cardiology, Institute of Emergency for Cardiovascular Diseases, UMF Carol Davila, Bucharest (Romania); Ector, Joris [Department of Cardiology, University Hospital Gasthuisberg, Leuven (Belgium); Wildiers, Hans [Department of Medical Oncology, University Hospital Gasthuisberg, Leuven (Belgium); Van den Bogaert, Walter [Department of Radiotherapy, University Hospital Gasthuisberg, Leuven (Belgium); Voigt, Jens-Uwe [Department of Cardiology, University Hospital Gasthuisberg, Leuven (Belgium)

2011-04-01T23:59:59.000Z

98

Extending the Sensitivity to the Detection of WIMP Dark Matter with an Improved Understanding of the Limiting Neutron Backgrounds  

SciTech Connect (OSTI)

The Cryogenic Dark Matter Search (CDMS) uses position-sensitive Germanium and Silicon crystals in the direct detection of Weakly Interacting Massive Particles (WIMPs) believed to constitute most of the dark matter in the Universe. WIMP interactions with matter being rare, identifying and eliminating known backgrounds is critical for detection. Event-by-event discrimination by the detectors rejects the predominant gamma and beta backgrounds while Monte Carlo simulations help estimate, and subtract, the contribution from the neutrons. This thesis describes the effort to understand neutron backgrounds as seen in the two stages of the CDMS search for WIMPs. The first stage of the experiment was at a shallow site at the Stanford Underground Facility where the limiting background came from high-energy neutrons produced by cosmic-ray muon interactions in the rock surrounding the cavern. Simulations of this background helped inform the analysis of data from an experimental run at this site and served as input for the background reduction techniques necessary to set new exclusion limits on the WIMP-nucleon cross-section, excluding new parameter space for WIMPs of masses 8-20 GeV/c{sup 2}. This thesis considers the simulation methods used as well as how various event populations in the data served as checks on the simulations to allow them to be used in the interpretation of the WIMP-search data. The studies also confirmed the presence of a limiting neutron background at the shallow site, necessitating the move to the 713-meter deep Soudan Underground Facility. Similar computer-based studies helped quantify the neutron background seen at the deeper site and informed the analysis of the data emerging from the first physics run of the experiment at Soudan. In conjunction with the WIMP-search and calibration data, the simulations confirmed that increased depth considerably reduced the neutron backgrounds seen, greatly improving the sensitivity to WIMP detection. The data run set an upper limit of 4 x 10{sup -43} on the WIMP-nucleon cross section for a WIMP mass of 60 GeV/c{sup 2} . Upper limits to the rate of background neutrons have also been determined.

Kamat, Sharmila; /Case Western Reserve U.; ,

2005-01-01T23:59:59.000Z

99

Mechanisms of Peritoneal Metastasis after Operation for Non-Serosa-invasive Gastric Carcinoma: An Ultrarapid Detection System for Intraperitoneal Free Cancer Cells and a Prophylactic Strategy for Peritoneal Metastasis  

Science Journals Connector (OSTI)

...Metastasis after Operation for Non-Serosa-invasive...Ultrarapid Detection System for Intraperitoneal...quantitative diagnosis system to detect i.p...cancer cells during operation at molecular level...metastasis after operation for non-serosa-invasive...ultrarapid detection system for intraperitoneal...

Takashi Marutsuka; Shinya Shimada; Kenji Shiomori; Naoko Hayashi; Yasushi Yagi; Takaaki Yamane; and Michio Ogawa

2003-02-01T23:59:59.000Z

100

Abstract B31: Implementation of video improves understanding of breast cancer concepts in an undereducated county hospital population  

Science Journals Connector (OSTI)

...meeting-abstract Behavioral and Social Science Health Education: Poster Presentations - Proffered Abstracts...International Conference on the Science of Cancer Health Disparities...health-related community education and outreach projects. Methods...

Gina R. Shirah; Marcia E. Bouton; Jesse Nodora; Chiu-Hsieh Hsu; Anne E. Klemens; Maria Elena Martinez; and Ian K. Komenaka

2010-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Cloud Detection with MODIS, Part I: Improvements in the MODIS Cloud Mask for Collection 5 *Richard A. Frey, Steven A. Ackerman, Yinghui Liu, Kathleen I. Strabala, Hong Zhang,  

E-Print Network [OSTI]

Cloud Detection with MODIS, Part I: Improvements in the MODIS Cloud Mask for Collection 5 *Richard.frey@ssec.wisc.edu August 2007 #12;ABSTRACT Significant improvements have been made to the MODIS cloud mask (MOD35 and MYD35 to the 3.9-12 m and 11-12 m cloud tests. More non-MODIS ancillary input data has been added. Land and sea

Sheridan, Jennifer

102

Bi-plane correlation imaging for improved detection of lung nodules Ehsan Samei1,2,3  

E-Print Network [OSTI]

approach that utilizes angular information from a bi-plane digital acquisition in conjunction with computer. The correlated suspect lesions were registered as positive. Using an optimum ­3o vertical geometry and processing. INTRODUCTION Lung cancer is a leading cause of death in the US, surpassing the mortality associated with breast

103

A study of time-based features and regularity of manipulation to improve the detection of eating activity  

E-Print Network [OSTI]

;Abstract This thesis considers the problem of detecting when people eat by tracking their wrist motion have been instrumental in my decision of pursuing my Master's degree. iii #12;Table of Contents Title

Hoover, Adam

104

Double molecular imprinting – a new sensor concept for improving selectivity in the detection of polycyclic aromatic hydrocarbons (PAHs) in water  

Science Journals Connector (OSTI)

...Highly selective and robust polymer coatings for the detection of polycyclic aromatic hydrocarbons (PAHs) in liquid media have been ... of aromatic rings. Measurements of PAHs in water were also performed with...

Franz L. Dickert; Paul Achatz…

2001-09-01T23:59:59.000Z

105

Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer  

E-Print Network [OSTI]

subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98(19): 10869-10   74 11   12   3. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch 13   AG, Samarajiwa S, Yuan Y, Graf S, Ha G, Haffari G, Bashashati A... WH, Sonke GS, van’t Veer LJ, Rutgers EJT, van de Vijver MJ, Linn SC. 3   Optimized prediction of clinical outcome by the PREDICT plus tool and 70-gene 4   signature in early stage node-negative breast cancer [abstract]. 36th Annual San Antonio 5...

Wishart, G. C.; Rakha, E.; Green, A.; Ellis, I.; Ali, H. R.; Provenzano, E.; Blows, F. M.; Caldas, C.; Pharoah, P. D. P.

2014-01-01T23:59:59.000Z

106

Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer  

SciTech Connect (OSTI)

Ultrasound imaging, having the advantages of low-cost and non-invasiveness over MRI and X-ray CT, was reported by several studies as an adequate complement to fluorescence molecular tomography with the perspective of improving localization and quantification of fluorescent molecular targets in vivo. Based on the previous work, an improved dual-modality Fluorescence-Ultrasound imaging system was developed and then validated in imaging study with preclinical tumor model. Ultrasound imaging and a profilometer were used to obtain the anatomical prior information and 3D surface, separately, to precisely extract the tissue boundary on both sides of sample in order to achieve improved fluorescence reconstruction. Furthermore, a pattern-based fluorescence reconstruction on the detection side was incorporated to enable dimensional reduction of the dataset while keeping the useful information for reconstruction. Due to its putative role in the current imaging geometry and the chosen reconstruction technique, we developed an attenuation compensated Born-normalization method to reduce the attenuation effects and cancel off experimental factors when collecting quantitative fluorescence datasets over large area. Results of both simulation and phantom study demonstrated that fluorescent targets could be recovered accurately and quantitatively using this reconstruction mechanism. Finally, in vivo experiment confirms that the imaging system associated with the proposed image reconstruction approach was able to extract both functional and anatomical information, thereby improving quantification and localization of molecular targets.

Li, Baoqiang; Berti, Romain; Abran, Maxime; Lesage, Frédéric, E-mail: frederic.lesage@polymtl.ca [Institute of Biomedical Engineering, École Polytechnique de Montréal, Montreal, Quebec H3C 3A7 (Canada) [Institute of Biomedical Engineering, École Polytechnique de Montréal, Montreal, Quebec H3C 3A7 (Canada); Montreal Heart Institute, Montreal, Quebec H1T 1C8 (Canada)

2014-05-15T23:59:59.000Z

107

Evaluation of compositing period and AVHRR and MERIS combination for improvement of spring phenology detection in deciduous forests  

Science Journals Connector (OSTI)

Accurate and precise detection of phenology events is needed to assess trends in seasonal vegetation development indicative of climate or other environmental change processes. In this research, detection accuracy of start of season (SOS) phenology for deciduous forest across Eastern Canada was assessed using satellite time series and in situ PlantWatch observations. Several aspects were evaluated regarding performance of phenology information extraction: 1) effect of compositing period, 2) individual performance of the Advanced Very High Resolution Radiometer (AVHRR) and the Medium Resolution Imaging Spectrometer (MERIS) sensors, and 3) performance for these sensors combined. The AVHRR and MERIS sensors were used as they are overlapping operational missions with planned future continuity. Three approaches to utilizing the multi-sensor data were tested: 1) inter-calibrating NDVI data between sensors and using the multi-sensor data stream to detect SOS, 2) combining independently derived SOS estimates from AVHRR and MERIS based on a weighted average, and 3) combining approaches 1 and 2. Comparison with in situ observations of leaf out and first bloom showed that combining independent SOS estimates from AVHRR and MERIS was better than using the inter-calibrated multi-sensor data. Combining SOS estimates from both sensors reduced error by 1–2 days compared to the individual sensor results. Composite periods from 7 to 11 days produced the best results for leaf out with a mean absolute error (MAE) of 5 days. Results for first bloom were not as good as those for leaf out, producing a MAE of 6.5 days. For first bloom, compositing periods greater than 11 days did not increase error at the same rate as seen for leaf out. However, the larger MAE observed for first bloom may have masked this effect.

Darren Pouliot; Rasim Latifovic; Richard Fernandes; Ian Olthof

2011-01-01T23:59:59.000Z

108

Improved Method of Fission Track Sample Preparation for Detecting Particles Containing Fissile Materials in Safeguards Environmental Samples  

Science Journals Connector (OSTI)

We have developed an effective method for fission track (FT) sample preparation to perform particle analysis of the safeguards environmental samples by the FT-thermal ionization mass spectrometry (TIMS) method. In this method, a FT detector and the layer containing particles are separated. The main feature of the developed FT sample is that the detection of a particle from the corresponding FT can be performed correctly and in a simple manner by fixing each one end of the detector and the particle layer and by using an etching tool. It is expected that this method will enhance the effectiveness of particle analysis.

Chi-Gyu Lee; Kazunari Iguchi; Fumitaka Esaka; Masaaki Magara; Satoshi Sakurai; Kazuo Watanabe; Shigekazu Usuda

2006-01-01T23:59:59.000Z

109

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer  

E-Print Network [OSTI]

--22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

Paxton, Anthony T.

110

Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression.  

Science Journals Connector (OSTI)

...hnRNP, heterogeneous nuclear ribonucle-oprotein...Hamamatsu Photonic Systems, Japan) was established using...Matsushita Co., Osaka, Japan). Inter-pretations...Disc Subtract Binary Nuclear Mask from Cytoplasm...studies will have 90% power to recognize detection...

M S Tockman; J L Mulshine; S Piantadosi; Y S Erozan; P K Gupta; J C Ruckdeschel; P R Taylor; T Zhukov; W H Zhou; Y L Qiao; and S X Yao

1997-12-01T23:59:59.000Z

111

Mathematical Modeling and Simulation of Colorectal Cancer.  

E-Print Network [OSTI]

??Understanding the cancer pathology and develop effective treatment strategies play significant roles in improving cancer survival rates. In this thesis, evaluations of mathematical modeling and… (more)

Saripalli, Manjeera

2011-01-01T23:59:59.000Z

112

Forward Intensity-Modulated Radiotherapy Planning in Breast Cancer to Improve Dose Homogeneity: Feasibility of Class Solutions  

SciTech Connect (OSTI)

Purpose: To explore forward planning methods for breast cancer treatment to obtain homogeneous dose distributions (using International Commission on Radiation Units and Measurements criteria) within normal tissue constraints and to determine the feasibility of class solutions. Methods and Materials: Treatment plans were optimized in a stepwise procedure for 60 patients referred for postlumpectomy irradiation using strict dose constraints: planning target volume (PTV){sub 95%} of >99%; V{sub 107%} of <1.8 cc; heart V{sub 5Gy} of <10% and V{sub 10Gy} of <5%; and mean lung dose of <7 Gy. Treatment planning started with classic tangential beams. Optimization was done by adding a maximum of four segments before adding beams, in a second step. A breath-hold technique was used for heart sparing if necessary. Results: Dose constraints were met for all 60 patients. The classic tangential beam setup was not sufficient for any of the patients; in one-third of patients, additional segments were required (<3), and in two-thirds of patients, additional beams (<2) were required. Logistic regression analyses revealed central breast diameter (CD) and central lung distance as independent predictors for transition from additional segments to additional beams, with a CD cut-off point at 23.6 cm. Conclusions: Treatment plans fulfilling strict dose homogeneity criteria and normal tissue constraints could be obtained for all patients by stepwise dose intensity modification using limited numbers of segments and additional beams. In patients with a CD of >23.6 cm, additional beams were always required.

Peulen, Heike, E-mail: h.peulen@nki.nl [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands); Hanbeukers, Bianca; Boersma, Liesbeth; Baardwijk, Angela van; Ende, Piet van den; Houben, Ruud; Jager, Jos; Murrer, Lars; Borger, Jacques [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands)

2012-01-01T23:59:59.000Z

113

LDRD final report on high power broadly tunable Mid-IR quantum cascade lasers for improved chemical species detection.  

SciTech Connect (OSTI)

The goal of our project was to examine a novel quantum cascade laser design that should inherently increase the output power of the laser while simultaneously providing a broad tuning range. Such a laser source enables multiple chemical species identification with a single laser and/or very broad frequency coverage with a small number of different lasers, thus reducing the size and cost of laser based chemical detection systems. In our design concept, the discrete states in quantum cascade lasers are replaced by minibands made of multiple closely spaced electron levels. To facilitate the arduous task of designing miniband-to-miniband quantum cascade lasers, we developed a program that works in conjunction with our existing modeling software to completely automate the design process. Laser designs were grown, characterized, and iterated. The details of the automated design program and the measurement results are summarized in this report.

Wanke, Michael Clement; Hudgens, James J.; Fuller, Charles T.; Samora, Sally; Klem, John Frederick; Young, Erik W.

2006-01-01T23:59:59.000Z

114

Improved detection of rough defects for ultrasonic NDE inspections based on finite element modeling of elastic wave scattering  

SciTech Connect (OSTI)

Defects which posses rough surfaces greatly affect ultrasonic wave scattering behaviour, often reducing the magnitude of reflected signals. Ultrasonic inspections rely upon this response for detecting and sizing flaws. For safety critical components reliable characterisation is crucial. Therefore, providing an accurate means to predict reductions in signal amplitude is essential. An extension of Kirchhoff theory has formed the basis for the UK power industry inspection justifications. However, it is widely recognised that these predictions are pessimistic owing to analytical approximations. A numerical full field modelling approach does not fall victim to such limitations. Here, a Finite Element model is used to aid in setting a non-conservative reporting threshold during the inspection of a large pressure vessel forging that might contain embedded rough defects. The ultrasonic response from multiple rough surfaces defined by the same statistical class is calculated for normal incident compression waves. The approach is validated by comparing coherent scattering with predictions made by Kirchhoff theory. At lower levels of roughness excellent agreement is observed, whilst higher values confirm the pessimism of Kirchhoff theory. Furthermore, the mean amplitude in the specular direction is calculated. This represents the information obtained during an inspection, indicating that reductions due to increasing roughness are significantly less than the coherent component currently being used.

Pettit, J. R. [Rolls-Royce Nuclear, PO BOX 2000, Derby, UK, DE21 7XX and Research Centre for NDE, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Walker, A. [Rolls-Royce Nuclear, PO BOX 2000, Derby DE21 7XX (United Kingdom); Lowe, M. J. S. [Research Centre for NDE, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom)

2014-02-18T23:59:59.000Z

115

Upfront Androgen Deprivation Therapy With Salvage Radiation May Improve Biochemical Outcomes in Prostate Cancer Patients With Post-Prostatectomy Rising PSA  

SciTech Connect (OSTI)

Purpose: The addition of androgen deprivation therapy (ADT) to definitive external beam radiation therapy (RT) improves outcomes in higher-risk prostate cancer patients. However, the benefit of ADT with salvage RT in post-prostatectomy patients is not clearly established. Our study compares biochemical outcomes in post-prostatectomy patients who received salvage RT with or without concurrent ADT. Methods and Materials: Of nearly 2,000 post-prostatectomy patients, we reviewed the medical records of 191 patients who received salvage RT at University of Pennsylvania between 1987 and 2007. Follow-up data were obtained by chart review and electronic polling of the institutional laboratory database and Social Security Death Index. Biochemical failure after salvage RT was defined as a prostate-specific antigen of 2.0 ng/mL above the post-RT nadir or the initiation of ADT after completion of salvage RT. Results: One hundred twenty-nine patients received salvage RT alone, and 62 patients received combined ADT and salvage RT. Median follow-up was 5.4 years. Patients who received combined ADT and salvage RT were younger, had higher pathologic Gleason scores, and higher rates of seminal vesicle invasion, lymph node involvement, and pelvic nodal irradiation compared with patients who received salvage RT alone. Patients who received combined therapy had improved biochemical progression-free survival (bPFS) compared with patients who received RT alone (p = 0.048). For patients with pathologic Gleason scores {<=}7, combined RT and ADT resulted in significantly improved bPFS compared to RT alone (p = 0.013). Conclusions: These results suggest that initiating ADT during salvage RT in the post-prostatectomy setting may improve bPFS compared with salvage RT alone. However, prospective randomized data are necessary to definitively determine whether hormonal manipulation should be used with salvage RT. Furthermore, the optimal nature and duration of ADT and the patient subgroups in which ADT could provide the most benefit remain open questions.

Jang, Joanne W. [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Hwang, Wei-Ting [Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Guzzo, Thomas J.; Wein, Alan J. [Department of Urology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Urology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Haas, Naomi B. [Department of Medical Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Medical Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Both, Stefan [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Vapiwala, Neha, E-mail: vapiwala@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)

2012-08-01T23:59:59.000Z

116

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung  

DOE Patents [OSTI]

A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.

Cole, D.A.; Moody, D.C. III; Ellinwood, L.E.; Klein, M.G.

1992-11-10T23:59:59.000Z

117

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

SciTech Connect (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

118

Cancer field effects in normal tissues revealed by Raman spectroscopy  

Science Journals Connector (OSTI)

It has been demonstrated that the presence of cancer results in detectable changes to uninvolved tissues, collectively termed cancer field effects (CFE). In this study, we directly...

Lieber, Chad A; Nethercott, Hubert E; Kabeer, Mustafa H

2010-01-01T23:59:59.000Z

119

Breast-Cancer Screening  

Science Journals Connector (OSTI)

....79 to 0.99) for death from breast cancer, the USPSTF previously recommended routine screening mammography for women in this age group. Since it had been argued that the benefit of screening women in their 40s could largely be attributed to the detection of cancers after the age of 50 years in women... This article reviews current recommendations for breast-cancer screening and the supporting evidence, including the controversy regarding mammographic screening of women in their 40s.

Warner E.

2011-09-15T23:59:59.000Z

120

A filter-based feature selection approach for identifying potential biomarkers for lung cancer  

E-Print Network [OSTI]

Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

2011-03-21T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Also in This Issue 2 International Cancer  

E-Print Network [OSTI]

Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

Müller, Jens-Dominik

122

Rates of Cancer Detection and Abnormal Results among Clients Recruited for Mammography through Outreach and Education Supported by the Avon Breast Health Outreach Program  

Science Journals Connector (OSTI)

meeting-abstract Poster Session Abstracts Social...patient satisfaction, and education in breast cancer care...patient satisfaction, and education among a recently diagnosed...least a 4-year college education (55.78%). Stage...

J Rose; KM Opdyke; K Gates-Ferris; and M Hurlbert

2012-12-17T23:59:59.000Z

123

Development of a Multiplexed Tumor-Associated Autoantibody-Based Blood Test for the Detection of Non–Small Cell Lung Cancer  

Science Journals Connector (OSTI)

...means to early disease detection. This...over 90% in the prediction of patients' samples...detect early-stage disease in patient cohorts...wheat embryos: plants apparently contain...Random Forests. Machine Learning 2001;45:5-32...

Erin C. Farlow; Kalpa Patel; Sanjib Basu; Bao-Shiang Lee; Anthony W. Kim; John S. Coon; L. Penfield Faber; Philip Bonomi; Michael J. Liptay; and Jeffrey A. Borgia

2010-07-01T23:59:59.000Z

124

Enhancement of Folate Receptor ? Expression in Tumor Cells Through the Glucocorticoid Receptor: A Promising Means to Improved Tumor Detection and Targeting  

Science Journals Connector (OSTI)

...the luciferase assay system (Promega). The samples...Gene Amp 5700 sequence detection system (Applied Biosystems...were treated with either vehicle alone or dexamethasone...treatment either with vehicle alone or with the indicated...

Thuyet Tran; Aymen Shatnawi; Xuan Zheng; Karen M.M. Kelley; and Manohar Ratnam

2005-05-15T23:59:59.000Z

125

A Knowledge-Based Approach to Improving and Homogenizing Intensity Modulated Radiation Therapy Planning Quality Among Treatment Centers: An Example Application to Prostate Cancer Planning  

SciTech Connect (OSTI)

Purpose: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality plans for outside clinics. We explore feasibility by generating plans for patient datasets from an outside institution by adapting plans from our institution. Methods and Materials: A knowledge database was created from 132 IMRT treatment plans for prostate cancer at our institution. The outside institution, a community hospital, provided the datasets for 55 prostate cancer cases, including their original treatment plans. For each “query” case from the outside institution, a similar “match” case was identified in the knowledge database, and the match case’s plan parameters were then adapted and optimized to the query case by use of a semiautomated approach that required no expert planning knowledge. The plans generated with this knowledge-based approach were compared with the original treatment plans at several dose cutpoints. Results: Compared with the original plan, the knowledge-based plan had a significantly more homogeneous dose to the planning target volume and a significantly lower maximum dose. The volumes of the rectum, bladder, and femoral heads above all cutpoints were nominally lower for the knowledge-based plan; the reductions were significantly lower for the rectum. In 40% of cases, the knowledge-based plan had overall superior (lower) dose–volume histograms for rectum and bladder; in 54% of cases, the comparison was equivocal; in 6% of cases, the knowledge-based plan was inferior for both bladder and rectum. Conclusions: Knowledge-based planning was superior or equivalent to the original plan in 95% of cases. The knowledge-based approach shows promise for homogenizing plan quality by transferring planning expertise from more experienced to less experienced institutions.

Good, David [Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Lo, Joseph [Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Department of Radiology and Departments of Biomedical Engineering and Electrical and Computer Engineering, Duke University, Durham, North Carolina (United States); Lee, W. Robert [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Wu, Q. Jackie; Yin, Fang-Fang [Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Das, Shiva K., E-mail: shiva.das@duke.edu [Medical Physics Graduate Program, Duke University, Durham, North Carolina (United States); Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)

2013-09-01T23:59:59.000Z

126

Lack of Osteoradionecrosis of the Mandible After Intensity-Modulated Radiotherapy for Head and Neck Cancer: Likely Contributions of Both Dental Care and Improved Dose Distributions  

SciTech Connect (OSTI)

Purpose: To assess the prevalence and dosimetric and clinical predictors of mandibular osteoradionecrosis (ORN) in patients with head and neck cancer who underwent a pretherapy dental evaluation and prophylactic treatment according to a uniform policy and were treated with intensity-modulated radiotherapy (IMRT). Methods and Materials: Between 1996 and 2005, all patients with head-and-neck cancer treated with parotid gland-sparing IMRT in prospective studies underwent a dental examination and prophylactic treatment according to a uniform policy that included extractions of high-risk, periodontally involved, and nonrestorable teeth in parts of the mandible expected to receive high radiation doses, fluoride supplements, and the placement of guards aiming to reduce electron backscatter off metal teeth restorations. The IMRT plans included dose constraints for the maximal mandibular doses and reduced mean parotid gland and noninvolved oral cavity doses. A retrospective analysis of Grade 2 or worse (clinical) ORN was performed. Results: A total of 176 patients had a minimal follow-up of 6 months. Of these, 31 (17%) had undergone teeth extractions before RT and 13 (7%) after RT. Of the 176 patients, 75% and 50% had received {>=}65 Gy and {>=}70 Gy to {>=}1% of the mandibular volume, respectively. Falloff across the mandible characterized the dose distributions: the average gradient (in the axial plane containing the maximal mandibular dose) was 11 Gy (range, 1-27 Gy; median, 8 Gy). At a median follow-up of 34 months, no cases of ORN had developed (95% confidence interval, 0-2%). Conclusion: The use of a strict prophylactic dental care policy and IMRT resulted in no case of clinical ORN. In addition to the dosimetric advantages offered by IMRT, meticulous dental prophylactic care is likely an essential factor in reducing ORN risk.

Ben-David, Merav A. [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States); Diamante, Maximiliano [Department of Oral and Maxillofacial Surgery/Hospital Dentistry, University of Michigan Medical School, Ann Arbor, MI (United States); Radawski, Jeffrey D. [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States); Vineberg, Karen A. [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States); Stroup, Cynthia [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States); Murdoch-Kinch, Carol-Anne [Department of Oral and Maxillofacial Surgery/Hospital Dentistry, University of Michigan Medical School, Ann Arbor, MI (United States); Zwetchkenbaum, Samuel R. [Department of Oral and Maxillofacial Surgery/Hospital Dentistry, University of Michigan Medical School, Ann Arbor, MI (United States); Eisbruch, Avraham [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States)]. E-mail: eisbruch@med.umich.edu

2007-06-01T23:59:59.000Z

127

Circulating Tumor DNA is Effective for the Detection of EGFR Mutation in Non-Small Cell Lung Cancer: A Meta-Analysis  

Science Journals Connector (OSTI)

...compared with current "gold standard", tumor tissues. Methods: We searched PubMed, EMBASE, Cochrane Library, and Web of Science to identify eligible studies which reported the sensitivity and specificity of ctDNA for detection of EGFR mutation status...

Mantang Qiu; Jie Wang; Youtao Xu; Xiangxiang Ding; Ming Li; Feng Jiang; Lin Xu; Rong Yin

128

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c  

E-Print Network [OSTI]

--22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

Paxton, Anthony T.

129

Application of a mercapto-terminated binuclear Cu(II) complex modified Au electrode to improve the sensitivity and selectivity for dopamine detection  

Science Journals Connector (OSTI)

Abstract A new mercapto-terminated binuclear Cu(II) complex, [Cu2Cl2(mtboc)2(C12H8N2)2] [mtboc =2-(methylthio)benzo[d]oxazole-5-carboxylic acid] (Cu2), was synthesized and characterized by single-crystal X-ray diffraction studies. The Cu2 complex was then immobilized on the surface of Au electrodes through \\{SAu\\} bonds to form a self-assembled monolayer. The electrochemical properties of the as-prepared Cu2- modified Au electrode (Au/Cu2) were investigated using cyclic voltammetry, electrochemical impedance spectroscopy, and differential pulse voltammetry (DPV). Moreover, as a biomimetic sensor for the determination of dopamine (DA) and uric acid (UA), the Au/Cu2 electrode exhibited excellent electrocatalytic activity for the oxidation of DA with a faster electron-transfer rate (6.61 s?1). The DPV technique was used for the trace determination of DA. The dependence of current vs. concentration was linear from 0.2 to 30 ?M with a regression coefficient of 0.9975, and the detection limit of DA was ? 0.08 ?M. Furthermore, the modified electrode clearly separated the DA signal from the interference effect of UA, thus realizing the simultaneous detection of DA and UA. Finally, the method was applied to the selective and precise analysis of DA in commercial injection and urine samples.

Guomin Jiang; Xuefang Gu; Guoqing Jiang; Tingting Chen; Wenyi Zhan; Shu Tian

2015-01-01T23:59:59.000Z

130

Advancing Explosives Detection Capabilities: Vapor Detection  

ScienceCinema (OSTI)

A new, PNNL-developed method provides direct, real-time detection of trace amounts of explosives such as RDX, PETN and C-4. The method selectively ionizes a sample before passing the sample through a mass spectrometer to detect explosive vapors. The method could be used at airports to improve aviation security.

Atkinson, David

2014-07-24T23:59:59.000Z

131

Cancer Cells DOI: 10.1002/anie.201100115  

E-Print Network [OSTI]

Cancer Cells DOI: 10.1002/anie.201100115 Micromachine-Enabled Capture and Isolation of Cancer Cells (CTCs) are the primary entities responsible for spawning cancer metastasis. Detection of CTCs provides an indicator for the clinical diagnosis and prognosis of various types of cancers. Several approaches, based

Zhang, Liangfang

132

Abstract 4542: Early detection of clinically significant prostate cancer at diagnosis: A prospective study using a novel panel of TMPRSS2:ETS fusion gene markers  

Science Journals Connector (OSTI)

...of fusion genes/subtypes or fusion-types were detected in 32 of 92 (34...identified a novel combination of fusion-types, termed Fx (III, V, ETS...biopsy. By incorporating the fusion-types Fx (III, V, ETS) with urine...

Phuong-Nam Nguyen; Sam Chan; Philippe Violette; Fadi Brimo; Yosh Taguchi; Armen Aprikian; and Junjian Z. Chen

2012-06-04T23:59:59.000Z

133

Folic Acid-Conjugated, SERS-Labeled Silver Nanotriangles for Multimodal Detection and Targeted Photothermal Treatment on Human Ovarian Cancer Cells  

Science Journals Connector (OSTI)

(6, 7) SERS detection and imaging in particular has generated quite an interest lately, by offering many advantages over traditional technologies as fluorescence and chemiluminiscence. ... The concentration of colloidal nanoparticles (?g/mL) was measured by atomic absorption spectroscopy (Avanta PM, GBC-Australia). ...

Sanda Boca-Farcau; Monica Potara; Timea Simon; Aurelie Juhem; Patrice Baldeck; Simion Astilean

2013-12-04T23:59:59.000Z

134

Circulating Tumor DNA is Effective for the Detection of EGFR Mutation in Non-Small Cell Lung Cancer: A Meta-Analysis  

Science Journals Connector (OSTI)

...ctDNA, compared with current "gold standard", tumor tissues. Methods: We searched PubMed, EMBASE, Cochrane Library, and Web of Science to identify eligible studies which reported the sensitivity and specificity of ctDNA for detection of EGFR mutation...

Mantang Qiu; Jie Wang; Youtao Xu; Xiangxiang Ding; Ming Li; Feng Jiang; Lin Xu; Rong Yin

135

Comprehensive detection of cancer gene expression profiles and gene networks are impacted by the choice of pre-processing algorithm and gene-selection method  

Science Journals Connector (OSTI)

Pre-processing algorithms (PPA) and gene-selection methods (GSM) are commonly employed to select Differentially Expressed Genes (DEGs) from microarray data. Previous studies established that different combinations of PPAs and GSMs are intrinsically different in their performance to select biologically relevant DEGs. In this study, we evaluated eight combinations of PPAs and GSMs for their ability to select DEGs for prioritising gene-networks. Although the different combinations yielded dissimilar DEG-lists, all DEG-lists selected could segregate tumour from normal. Nevertheless, the DEG-list selected significantly impacted the prioritisation of cancer-associated gene-networks; hence the initial choice of PPA and GSM is crucial for subsequent interactome investigations.

N. Baskaran; Chee Keong Kwoh; Kam M. Hui

2013-01-01T23:59:59.000Z

136

Volume-Based Parameters of {sup 18}F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Improve Disease Recurrence Prediction in Postmastectomy Breast Cancer Patients With 1 to 3 Positive Axillary Lymph Nodes  

SciTech Connect (OSTI)

Purpose: To determine whether volume-based parameters on pretreatment {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography in breast cancer patients treated with mastectomy without adjuvant radiation therapy are predictive of recurrence. Methods and Materials: We retrospectively analyzed 93 patients with 1 to 3 positive axillary nodes after surgery, who were studied with {sup 18}F-fluorodeoxyglucose positron emission tomography/computed tomography for initial staging. We evaluated the relationship between positron emission tomography parameters, including the maximum standardized uptake value, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), and clinical outcomes. Results: The median follow-up duration was 45 months. Recurrence was observed in 11 patients. Metabolic tumor volume and TLG were significantly related to tumor size, number of involved nodes, nodal ratio, nuclear grade, estrogen receptor (ER) status, and triple negativity (TN) (all P values were <.05). In receiver operating characteristic curve analysis, MTV and TLG showed better predictive performance than tumor size, ER status, or TN (area under the curve: 0.85, 0.86, 0.79, 0.74, and 0.74, respectively). On multivariate analysis, MTV was an independent prognostic factor of locoregional recurrence-free survival (hazard ratio 34.42, 95% confidence interval 3.94-882.71, P=.0008) and disease-free survival (DFS) (hazard ratio 13.92, 95% confidence interval 2.65-103.78, P=.0018). The 3-year DFS rate was 93.8% for the lower MTV group (<53.1; n=85) and 25.0% for the higher MTV group (?53.1; n=8; P<.0001, log–rank test). The 3-year DFS rate for patients with both ER-positive status and MTV <53.1 was 98.2%; and for those with ER-negative status and MTV ?53.1 it was 25.0% (P<.0001). Conclusions: Volume-based parameters improve recurrence prediction in postmastectomy breast cancer patients with 1 to 3 positive nodes. The addition of MTV to ER status or TN has potential benefits to identify a subgroup at higher risk for recurrence.

Nakajima, Naomi, E-mail: haruhi0321@gmail.com [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Department of Radiology, Ehime University, Ehime (Japan); Kataoka, Masaaki [Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Sugawara, Yoshifumi [Department of Diagnostic Radiology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Ochi, Takashi [Department of Radiology, Ehime University, Ehime (Japan); Kiyoto, Sachiko; Ohsumi, Shozo [Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Ehime (Japan); Mochizuki, Teruhito [Department of Radiology, Ehime University, Ehime (Japan)

2013-11-15T23:59:59.000Z

137

Three-Dimensional Thermal Tomography Advances Cancer Treatment...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

138

Detection Science  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry for Measurement and Detection Science Chemistry for Measurement and Detection Science Project Description Chemistry used in measurement and detection science plays a...

139

Improving Tamper Detection for Hazardous Waste Security  

SciTech Connect (OSTI)

Since September 11, waste managers are increasingly expected to provide effective security for their hazardous wastes. Tamper-indicating seals can help. This paper discusses seals, and offers recommendations for how to choose and use them.

Johnston, R. G.; Garcia, A. R. E.; Pacheco, N.; Martinez, R. K.; Martinez, D. D.; Trujillo, S. J.; Lopez, L. N.

2003-02-26T23:59:59.000Z

140

Improved Flame Photometric Detection Without Solvent Flameout  

Science Journals Connector (OSTI)

......Chelating Agents in Steam Propulsion Systems by Paul J. Sniegoski...iminodi- acetic acid) in steam propulsion systems. For chromatogra...as an addi- tive to steam propulsion systems to prevent build-up...Fourth Internaval Conference on Marine Cor- rosion, Naval Research......

Charles A. Burgett; Louis E. Green

1974-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Improved probability of detection of ecological “surprises”  

Science Journals Connector (OSTI)

...gophers), and control areas open...disturbance than the control plots. Hence...experimental treatments provided a...constituent plant species over time...knowledge of a system that draws...completed and then integrated (e.g...and in the control of invasive...not be, a waste of time . J...

D. B. Lindenmayer; G. E. Likens; C. J. Krebs; R. J. Hobbs

2010-01-01T23:59:59.000Z

142

Predictive and therapeutic markers in ovarian cancer  

DOE Patents [OSTI]

Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

2013-03-26T23:59:59.000Z

143

[CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief  

E-Print Network [OSTI]

[CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

Jin, Jiashun

144

Early Detection Saves Lives | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Low-dose image scanner In 2000, the WHPP added low-dose CT scanning for early lung cancer detection to the medical screening on a pilot basis at a limited number of DOE sites,...

145

Quantitative spectroscopy for detection of cervical dysplasia  

E-Print Network [OSTI]

The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection ...

Mirkovi?, Jelena, Ph. D. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

146

PERIAMPULLARY CANCERS: Are There Differences?  

Science Journals Connector (OSTI)

By definition, periampullary cancers arise within 2 cm of the major papilla in the duodenum. They encompass four different types of cancers: ampullary (ampulla of Vater), biliary (intrapancreatic distal bile duct), pancreatic (head–uncinate process), and duodenal (mainly from the second portion). Although these tumors have different origins, the complex regional anatomy and their proximation within that confined region generally dictate a common operative approach. Radical resections, such as the Whipple procedure 62 or its variant with preservation of the pylorus with or without extended regional lymphadenectomy,58 have been the main treatments for these cancers, especially with the currently low morbidity and mortality rates.67 Although the perioperative outcomes for these different cancers are similar, the long-term survival has traditionally varied. Consequently, because exact tumor origin is often difficult to clinically ascertain, surgeons have favored an aggressive approach toward resection to benefit those patients harboring cancers with a better prognosis. This observation has intrigued physicians managing patients with these cancers. It is unknown why outcome should vary for adenocarcinomas arising from different anatomic sites in such close proximity. Indeed, if survival does vary significantly for these cancers as clinical impression suggests, clearly, factors other than anatomy alone must be involved. This article explores whether there are differences in the clinical behavior of the periampullary cancers and defines which of these factors, if any, affect outcome. Moreover, it is important to determine which factors are valuable clinically so that they can be used to improve overall survival rates.

Juan M. Sarmiento; David M. Nagorney; Michael G. Sarr; Michael B. Farnell

2001-01-01T23:59:59.000Z

147

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM  

E-Print Network [OSTI]

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

Illinois at Chicago, University of

148

New Mechanism Based Anticancer Drugs for Treatment of Pancreatic and Bladder Cancers  

E-Print Network [OSTI]

-1977. The increase in survival is due to progress in diagnosing certain cancers at an earlier stage and improvements in treatment. ___________ This dissertation follows the style of Cancer Research. 2 Survival statistics vary greatly by country/region, cancer... bladder are most common and account for about 50% of all newly diagnosed cancers. The three most commonly diagnosed types of cancer among women in 2009 are cancers of the breast, lung and bronchus, and colon and rectum which accounting for 51...

Jutooru, Indira Devi

2011-08-08T23:59:59.000Z

149

Friend to Friend Cancer Early Detection  

E-Print Network [OSTI]

, Brooks, Burnet, Cameron, Carson, Cass, Castro, Cherokee, Childress, Clay, Colorado, Cooke, Cochran

150

Cancer, Palliative and End of Life Care ResearchProjects2012  

E-Print Network [OSTI]

Cancer, Palliative and End of Life Care ResearchProjects2012 #12;2 5 4 Cancer, Palliative and End and students working together to transform care and improve outcomes for individuals affected by cancer, other the right questions to generate theory, influence policy and change practice. Cancer survivorship

Anderson, Jim

151

The Cytokinesis-Blocked Micronucleus Assay as a Strong Predictor of Lung Cancer: Extension of a Lung Cancer Risk Prediction Model  

Science Journals Connector (OSTI)

...independent external lung cancer population and test discriminatory power improvement of the...506 participants were stratified into a test set of 995 (527 cases/468 controls...independent lung cancer population and test the effect of extending an existing lung...

Randa A. El-Zein; Mirtha S. Lopez; Anthony M. D'Amelio, Jr; Mei Liu; Reginald F. Munden; David Christiani; Li Su; Paula Tejera-Alveraz; Rihong Zhai; Margaret R. Spitz; Carol J. Etzel

2014-11-01T23:59:59.000Z

152

Detecting financial statement fraud: Three essays on fraud predictors, multi-classifier combination and fraud detection using data mining.  

E-Print Network [OSTI]

??The goal of this dissertation is to improve financial statement fraud detection using a cross-functional research approach. The efficacy of financial statement fraud detection depends… (more)

Perols, Johan L

2008-01-01T23:59:59.000Z

153

Prospective memory impairment in early breast cancer survivors: Finally homing in on the real deficit?  

Science Journals Connector (OSTI)

...2012; San Antonio, TX Prospective memory impairment in early breast cancer survivors...early breast cancer (EBC) treatment on memory functioning. One limitation of existing...may not be sensitive enough to detect memory problems as encountered in daily life...

S Verma; B Collins; X Song; M Bedard; L Paquet

2012-12-17T23:59:59.000Z

154

Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies  

Science Journals Connector (OSTI)

...colorectal, bladder, gastroesophoageal, pancreatic, breast, melanoma, hepatocellular and head and neck cancers, but in less than 50% of primary brain, renal, prostate, or thyroid cancers. In patients with localized tumors, ctDNA was detected...

Chetan Bettegowda; Mark Sausen; Rebecca Leary; Isaac Kinde; Nishant Agrawal; Bjarne Bartlett; Hao Wang; Brandon Luber; Kenneth Kinzler; Bert Vogelstein; Nickolas Papadopoulos; Luis Diaz

2014-10-01T23:59:59.000Z

155

Breast Cancer Prognostic Biomarker Using Attractor Metagenes and the FGD3–SUSD3 Metagene  

Science Journals Connector (OSTI)

...study toward developing a breast cancer prognostic test derived from and improving upon that model. Methods...identifying the optimal selection of features for the test. Results: The resulting test, called BCAM (Breast Cancer Attractor Metagenes...

Tai-Hsien Ou Yang; Wei-Yi Cheng; Tian Zheng; Matthew A. Maurer; Dimitris Anastassiou

2014-12-01T23:59:59.000Z

156

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells  

E-Print Network [OSTI]

Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ...

Papa, Anne-Laure

157

Refractory Improvement  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Refractory Improvement Refractory Improvement NETL Office of Research and Development Project Number: FWP-2012.03.03 Task 2 Project Description Industry would like gasifier on-line availability of 85-95% for utility applications and 95% for applications such as chemical production. Gasification facilities' are currently unable to meet these requirements, which have created a potential roadblock to widespread acceptance and commercialization of gasification technologies. Refractory liners and syngas coolers are among key components of the gasification process previously identified as negatively impacting gasifier availability. Ash originating from impurities in the gasifier's carbon feedstock is the root cause of many problems impacting gasifier RAM (Reliability Availability Maintainability). At the high temperatures of gasification, ash changes to liquid, gas, and solid phases which wear down refractory materials and can cause fouling, either of which can lead to unplanned shutdowns for system repair, replacement, or cleaning.

158

Josephine Ford Cancer Center Cancer Research Programs  

E-Print Network [OSTI]

Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

Berdichevsky, Victor

159

Ultrasound-guided percutaneous ethanol injection in papillary thyroid cancer metastatic lymph-nodes  

Science Journals Connector (OSTI)

Post-operative neck nodal metastases are detected in 9–20 % of papillary thyroid cancer (PTC). Ultrasound-guided ethanol injection (UPEI) has been used with...

Guia Vannucchi; Danila Covelli; Michela Perrino; Simone De Leo…

2014-11-01T23:59:59.000Z

160

Relating to ion detection  

DOE Patents [OSTI]

The apparatus and method provide a technique for improving detection of alpha and/or beta emitting sources on items or in locations using indirect means. The emission forms generate ions in a medium surrounding the item or location and the medium is then moved to a detecting location where the ions are discharged to give a measure of the emission levels. To increase the level of ions generated and render the system particularly applicable for narrow pipes and other forms of conduits, the medium pressure is increased above atmospheric pressure. STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Orr, Christopher Henry (Calderbridge, GB); Luff, Craig Janson (Calderbridge, GB); Dockray, Thomas (Calderbridge, GB); Macarthur, Duncan Whittemore (Los Alamos, NM)

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

UCSC cancer genomics browser.  

Science Journals Connector (OSTI)

...Chicago, IL Abstract 5087: UCSC Cancer Genomics Browser 2.0 Jingchun Zhu 1 Brian Craft...and analyze that data. The UCSC Cancer Genomics Browser (https://genome-cancer...enhances the interpretability of the cancer genomics information. UCSC Cancer Genomics Browser...

J Zhu; JZ Sanborn; T Wang; F Hsu; S Benz; C Szeto; L Esserman; D Haussler

2009-01-15T23:59:59.000Z

162

1 888 939 3333 | cancer.ca Cancer Statistics  

E-Print Network [OSTI]

1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

Habib, Ayman

163

Bonus -- Cameras Designed to Strengthen Nuclear Security Can Also Detect  

Broader source: Energy.gov (indexed) [DOE]

to Strengthen Nuclear Security Can Also to Strengthen Nuclear Security Can Also Detect Cancer Bonus -- Cameras Designed to Strengthen Nuclear Security Can Also Detect Cancer November 17, 2010 - 4:02pm Addthis Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs What does this mean for me? The cameras can detect prostate cancer -- as well as cervical, colorectal and breast cancers -- and can be optimized as a surgical probe that guides the removal of cancerous tumors. Brookhaven National Laboratory (BNL) and Hybridyne Imaging Technologies, Inc. recently won the 2010 North American Frost & Sullivan Award for Technology Innovation of the Year. The award is given out each year to a company that finds a new application for a unique technology. With funding from the Energy Department's NNSA's Office of Nonproliferation and

164

Improved aethalometer  

DOE Patents [OSTI]

An improved aethalometer having a single light source and a single light detector and two light paths from the light source to the light detector. A quartz fiber filter is inserted in the device, the filter having a collection area in one light path and a reference area in the other light path. A gas flow path through the aethalometer housing allows ambient air to flow through the collection area of the filter so that aerosol particles can be collected on the filter. A rotating disk with an opening therethrough allows light for the light source to pass alternately through the two light paths. The voltage output of the detector is applied to a VCO and the VCO pulses for light transmission separately through the two light paths, are counted and compared to determine the absorption coefficient of the collected aerosol particles. 5 figs.

Hansen, A.D.

1988-01-25T23:59:59.000Z

165

Cantilever MEMS Detection ofCantilever MEMS Detection of CancerCancer  

E-Print Network [OSTI]

.O. Soboyejo Department of Mechanical and Aerospace Engineering Princeton University, Olden Street, Princeton of of proteins between nucleus and plasma membranes. Vimentin is expressed only during the early stages

Petta, Jason

166

Internal Validation of Procedure Codes on Medicare Claims for Digital Mammograms and Computer-Aided Detection  

Science Journals Connector (OSTI)

...for Digital Mammograms and Computer-Aided Detection Joshua J...Washington, Seattle, Washington Grant support: American Cancer Society Mentored Research Scholars Grant (MRSGT-05-214-01-CPPB...as digital mammography and computer-aided detection (CAD...

Joshua J. Fenton; Pamela Green; and Laura-Mae Baldwin

2009-08-01T23:59:59.000Z

167

Cervical Cancer Burden and Prevention Strategies: Asia Oceania Perspective  

Science Journals Connector (OSTI)

...cancer, economic status, political background, cultures...DNA positive for high-risk genotypes, with detection...cytology National Health Insurance Corp. (NHIC) since...Australasia and Oceania: risk-factors, epidemiology...distribution and differential risks of human papillomavirus...

Suzanne M. Garland; Neerja Bhatla; and Hextan Y.S. Ngan

2012-09-01T23:59:59.000Z

168

Exploring Strategies for Melanoma Detection Utilizing Discrimination Training  

E-Print Network [OSTI]

Melanoma is the deadliest form of skin cancer. Although melanoma is amenable to visual identification by those who might suffer from the disease, no consensus exists on a single strategy for promoting early detection. To ...

Miller, Jonathan Richard

2013-08-31T23:59:59.000Z

169

Detection threshold  

Science Journals Connector (OSTI)

Detection threshold or recognition differential is defined as the signal?to?noise ratio at the beamformer output required for detection. An introduction to this topic is provided in Uricks’ Principles of Underwater Sound. The subject is frequently a source of confusion due to the multiple possible definitions of signal?to?noise ratio the effects of nonlinearities in the signal processing and the overall complexity of the sonar operators job of signal recognition in real?world clutter. In this paper a review of the basic theory of mathematical relationships are provided followed by a discussion of practical limitations in applying simple formulas to performance predictions. The relationships of detection threshold to the signal?processing approach and background?noise statistics are discussed. Active sonars in both noise and reverberation as well as passive sonars involving energy detection spectral analysis and cross correlators are discussed.

Henry Cox

1999-01-01T23:59:59.000Z

170

CancerCancer SBL101SBL101  

E-Print Network [OSTI]

CancerCancer SBL101SBL101 James Gomes School of Biological Sciences Indian Institute of Technology either Block the control point so that cell cycle continues in the absence of telomeres Acquire

Mittal, Aditya

171

Circulating Tumor Cells in Perioperative Esophageal Cancer Patients: Quantitative Assay System and Potential Clinical Utility  

Science Journals Connector (OSTI)

...This developed system can detect CEA mRNA-positive...Esophageal cancer operation results in tumor...functions of body immune system because significant...stimulation of surgical operation in these patients...This developed system can detect CEA mRNA-positive...Esophageal cancer operation results in tumor...

Zhian Liu; Ming Jiang; Jianhua Zhao; and Huangxian Ju

2007-05-15T23:59:59.000Z

172

Accelerators for Cancer Therapy  

DOE R&D Accomplishments [OSTI]

The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

Lennox, Arlene J.

2000-05-30T23:59:59.000Z

173

The National Cancer Institute,  

E-Print Network [OSTI]

The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

174

CANCER BIOLOGY Infectioustumourcells  

E-Print Network [OSTI]

CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

Nowak, Martin A.

175

Cancer vaccines: Material breach  

Science Journals Connector (OSTI)

... Willem Overwijk, a tumour immunologist who studies melanoma vaccines at MD Anderson Cancer Center in Houston, ...

Elie Dolgin

2013-12-18T23:59:59.000Z

176

Acoustic enhancement for photo detecting devices  

DOE Patents [OSTI]

Provided are improvements to photo detecting devices and methods for enhancing the sensitivity of photo detecting devices. A photo detecting device generates an electronic signal in response to a received light pulse. An electro-mechanical acoustic resonator, electrically coupled to the photo detecting device, damps the electronic signal and increases the signal noise ratio (SNR) of the electronic signal. Increased photo detector standoff distances and sensitivities will result.

Thundat, Thomas G; Senesac, Lawrence R; Van Neste, Charles W

2013-02-19T23:59:59.000Z

177

Fingerprint detection  

DOE Patents [OSTI]

A method for detection and visualization of latent fingerprints is provided and includes contacting a substrate containing a latent print thereon with a colloidal metal composition for time sufficient to allow reaction of said colloidal metal composition with said latent print, and preserving or recording the observable print. Further, the method for detection and visualization of latent fingerprints can include contacting the metal composition-latent print reaction product with a secondary metal-containing solution for time sufficient to allow precipitation of said secondary metal thereby enhancing the visibility of the latent print, and preserving or recording the observable print.

Saunders, George C. (Rt. 1, Box 428B, Espanola, NM 87532)

1992-01-01T23:59:59.000Z

178

Ris-M-2873 Improvement ofthe Bandwidth  

E-Print Network [OSTI]

of the system is given by * L = C ( T L + T D ) / 2 , where c is the speed of light, T L the laser pulse. Measuring methods 6 B. Measuring results 7 C. Possibilities of improvements 8 II. IMPROVEMENT profiles. The spectrum of the back-scattered light is recorded as a function of time by a detection system

179

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER  

E-Print Network [OSTI]

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

Sherman, S. Murray

180

Detection device  

DOE Patents [OSTI]

The present invention is directed to a detection device comprising: (1) an entrance chamber, (2) a central chamber, and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

Smith, Jay E. (Pittsburgh, PA)

1984-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Ramucirumab: Successfully Targeting Angiogenesis in Gastric Cancer  

Science Journals Connector (OSTI)

...Holcombe Boulevard, Unit 426, Houston, TX 77030. Fax: 713-645-8620; E-mail...postoperative adjuvant therapy have led to survival improvement for early-stage gastric...Unfortunately, advanced gastric cancer continues to pose a formidable challenge with few gains...

Milind Javle; Elizabeth C. Smyth; Ian Chau

2014-12-01T23:59:59.000Z

182

Paul Workman Cancer Research UK Cancer Therapeutics Unit  

E-Print Network [OSTI]

Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

183

Implementation Science in Cancer Prevention and Control: A Framework for Research and Programs in Low- and Middle-Income Countries  

Science Journals Connector (OSTI)

...and detection. Several mobile health (mhealth) initiatives that utilize cell phone...telecommunications technology in LMICs, mhealth and may offer a practical approach to...and early detection (e.g., use of mHealth technologies in cancer prevention...

Sudha Sivaram; Michael A. Sanchez; Barbara K. Rimer; Jonathan M. Samet; Russell E. Glasgow

2014-11-01T23:59:59.000Z

184

Unsupervised density-based behavior change detection in data streams  

Science Journals Connector (OSTI)

The ability to detect changes in the data distribution is an important issue in Data Stream mining. Detecting changes in data distribution allows the adaptation of a previously learned model to accommodate the most recent data and, therefore, improve ... Keywords: Change Detection, Clustering, Data Streams, Novelty Detection, Unsupervised Learning

Rosane M. M. Vallim; José A. Andrade Filho; Rodrigo F. de Mello; André C. P. L. F. de Carvalho; João Gama

2014-03-01T23:59:59.000Z

185

Follow-up care instructions, treatment summaries, and cancer survivors’ receipt of follow-up health care and late/long term effects  

Science Journals Connector (OSTI)

Cancer survivors need follow-up care. Survivorship care plans (SCP), including follow-up care instructions (FCI) and treatment summaries (TS), were designed to improve cancer survivors’ receipt of follow-up ca...

Jennifer M. Jabson

2014-12-01T23:59:59.000Z

186

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2011-10-04T23:59:59.000Z

187

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

188

Cancer Research Beckman Institute  

E-Print Network [OSTI]

Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

Illinois at Urbana-Champaign, University of

189

Patch Clamp Detection in Capillary Electrophoresis  

Science Journals Connector (OSTI)

Patch Clamp Detection in Capillary Electrophoresis ... Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches ... The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches. ...

Kent Jardemark; Owe Orwar; Ingemar Jacobson; Alexander Moscho; Richard N. Zare

1997-09-01T23:59:59.000Z

190

Lung Cancer Screening and clinical implications.  

E-Print Network [OSTI]

??abstractLung cancer is the most frequently diagnosed major cancer worldwide and the leading cause of death from cancer. Lung cancer is divided into two subgroups:… (more)

S.C. van 't Westeinde (Susan)

2012-01-01T23:59:59.000Z

191

Handbook of Cancer Survivorship  

Science Journals Connector (OSTI)

...problems or reduce their effects? Michael Feuerstein has assembled a distinguished cadre of scientists to answer some of these questions in the Handbook of Cancer Survivorship. To my knowledge, this is the first book that targets health care professionals who work with survivors of adult cancer. Most... The victories over cancer in the past three decades have given us much to celebrate. In the United States alone, there are now more than 10.5 million cancer survivors. We have also learned that there can be a cost to curing cancer, and thus the emphasis ...

Oeffinger K.C.

2007-06-14T23:59:59.000Z

192

Is Adjuvant Chemoradiotherapy Overtreatment in Cervical Cancer Patients With Intermediate Risk Factors?  

SciTech Connect (OSTI)

Purpose: To determine whether adjuvant chemoradiotherapy (CRT) improves the outcome of cervical cancer patients with intermediate risk factors. Methods and Materials: Between January 2000 and June 2006, the medical records of 735 patients who had undergone radical surgery for Stage IB-IIA cervical cancer were reviewed retrospectively. Of the 735 patients, 172 with two or more intermediate risk factors (i.e., lymphovascular space involvement, deep stromal invasion, and tumor size {>=}2 cm) were grouped as follows according to the adjuvant treatment received: 34 patients, no further treatment; 49 patients, RT; and 89 patients, CRT. The significance of the clinical parameters and recurrence-free survival of each group were analyzed. Results: Of the 172 patients with any of the intermediate risk factors, 137 (79.6%) had two or more intermediate risk factors. Of the 172 patients, 12 developed recurrences (6.4%)->(7.0%), with 6 in the pelvis and 6 in distant sites. All 12 recurrences occurred in those who had two or more intermediate risk factors (sensitivity, 100%); however, only six recurrences were detected in patients who met the Gynecologic Oncology Group criteria for the intermediate-risk group (sensitivity, 50%; Z test, p < .05). A statistically significant difference was found in the 3-year recurrence-free survival rate among the no further treatment, RT, and CRT groups (67.5%, 90.5%, and 97.5%, respectively; p < .05). The incidence of Grade 3-4 hematologic and gastrointestinal toxicities was not significantly different statistically between the RT and CRT groups (6.1% and 13.4%, respectively; p > .05). Conclusion: Postoperative adjuvant CRT can improve the outcome of cervical cancer patients with intermediate risk factors, with low increase in toxicity.

Ryu, Sang-Young, E-mail: ryu@kcch.re.k [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Park, Sang-Il [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Nam, Byung-Ho [Center for Clinical Trials, National Cancer Center, Kyongi (Korea, Republic of); Cho, Chul-Koo [Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Kidong; Kim, Beob-Jong; Kim, Moon-Hong; Choi, Seok-Cheol; Lee, Eui-Don; Lee, Kyoung-Hee [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

2011-03-01T23:59:59.000Z

193

Bonus -- Cameras Designed To Strengthen Nuclear Security Can Also Detect  

Broader source: Energy.gov (indexed) [DOE]

To Strengthen Nuclear Security Can Also To Strengthen Nuclear Security Can Also Detect Cancer Bonus -- Cameras Designed To Strengthen Nuclear Security Can Also Detect Cancer November 17, 2010 - 4:04pm Addthis Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs What does this mean for me? Thanks to researchers from Brookhaven National Laboratory, a high-resolution gamma camera exists that can be used to detect prostate cancer. Brookhaven National Laboratory (BNL) and Hybridyne Imaging Technologies, Inc. recently won the 2010 North American Frost & Sullivan Award for Technology Innovation of the Year. The award is given out each year to a company that finds a new application for a unique technology. With funding from the Department of Energy's NNSA's Office of Nonproliferation and

194

Fuel washout detection system  

DOE Patents [OSTI]

A system for detecting grossly failed reactor fuel by detection of particulate matter as accumulated on a filter.

Colburn, Richard P. (Pasco, WA)

1985-01-01T23:59:59.000Z

195

Cancer Stem Cells in Hepatocellular Cancer  

Science Journals Connector (OSTI)

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and typically portends a poor prognosis with a median survival ranging from 6 to 16 months. In the United States, a total of 24,120 new ...

Russell C. Langan; Itzhak Avital

2011-01-01T23:59:59.000Z

196

Improved Stool DNA Integrity Method for Early Colorectal Cancer Diagnosis  

Science Journals Connector (OSTI)

...semiautomatic extraction systems and analyzed using FL-DNA tests by CE and RT assays. The RT FL-DNA approach showed...be classified into three broad categories: stool tests [fecal occult blood test (FOBT)], endoscopic examinations (flexible sigmoidoscopy...

Claudia Rengucci; Giulia De Maio; Maura Menghi; Emanuela Scarpi; Simona Guglielmo; Pietro Fusaroli; Giancarlo Caletti; Luca Saragoni; Andrea Casadei Gardini; Wainer Zoli; Fabio Falcini; Dino Amadori; Daniele Calistri

2014-11-01T23:59:59.000Z

197

Building on Clues: Improving Methods to Detect and  

E-Print Network [OSTI]

;Project Overview · Problem: Limited guidance on how to collect, analyze and share counterterrorism, 1999-2009 Anti-Abortion Animal Rights Anti-Muslim Right Left Ideology/Motivation Excecuted Similar

McShea, Daniel W.

198

Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from  

E-Print Network [OSTI]

Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

Paris-Sud XI, Université de

199

Cancer Due to Prolonged Inflammation  

E-Print Network [OSTI]

Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

200

Genetic susceptibility of cervical cancer.  

E-Print Network [OSTI]

??Cervical cancer is the third most common cancer in women worldwide. Lifetime risks for cervical cancer range from 0.4% in Israel to 5,3% in Colombia,… (more)

Zoodsma, Margreet

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

National Cancer Institute Thesaurus  

Science Journals Connector (OSTI)

The NCI Thesaurus is a comprehensive collection of terms relating ... clinical oncology, and cancer epidemiology. The NCI Thesaurus was conceived in the 1990s as a...

Prof. Mark A. Musen

2013-01-01T23:59:59.000Z

202

No Association Between Dietary Glycemic Index or Load and Pancreatic Cancer Incidence in Postmenopausal Women  

Science Journals Connector (OSTI)

...glycemic index|glycemic load|pancreatic cancer...GI) and glycemic load (GL) values have...Cancer Registry. Data Analysis We excluded...being tested. Our power was 80 to detect a...biologically plausible, the data from our study do...Brand-Miller JC. Glycemic load and chronic disease...

Kimberly J. Johnson; Kristin E. Anderson; Lisa Harnack; Ching-Ping Hong; and Aaron R. Folsom

2005-06-01T23:59:59.000Z

203

Integrating biological knowledge, novel imaging modalities, and modeling in breast cancer diagnosis  

Science Journals Connector (OSTI)

Despite tremendous advances in modern imaging technology, both early detection and accurate diagnosis of breast cancer are still unresolved challenges. Today, a variety of imaging modalities and image-guided biopsy procedures exist to identify and characterize ... Keywords: breast cancer, computer aided diagnosis, image registration, multimodal imaging

Nico Karssemeijer; Henkjan Huisman; David Hawkes; John Hipwell; Tobias Böhler; Jan Lesniak; Christine Tanner; Gabor Szekely; Wiro Niessen; Horst Hahn

2009-06-01T23:59:59.000Z

204

Role of hypoxia and hypoxia induced factors in the development of breast cancer brain metastasis  

E-Print Network [OSTI]

Here we studied the role of hypoxia and hypoxia-induced factors in the development of breast cancer brain metastasis by using ENU1564, a carcinogen-induced mammary adenocarcinoma cell line. We detected hypoxia noninvasively by using a novel...

Lungu, Gina Florentina

2009-05-15T23:59:59.000Z

205

Cancer and the medicare disabled.  

E-Print Network [OSTI]

??This dissertation examines relationships between cancer in working-age adults and enrollment in Medicare due disability. We examine whether cancer diagnosis and treatments affect enrollment in… (more)

Habermann, Elizabeth Anne

2008-01-01T23:59:59.000Z

206

Improving Interpersonal Communication  

E-Print Network [OSTI]

By improving interpersonal communication skills, we can improve our relationships with others. Better communication comes from understanding one's self, understanding other people, learning to empathize, being a good listener and practicing...

Warren, Judith L.

2000-02-16T23:59:59.000Z

207

Unanticipated potential cancer risk near metal recycling facilities  

SciTech Connect (OSTI)

Metal recycling is an important growing industry. Prior to this study, area sources consisting of metal recycling facilities fell in a category of limited regulatory scrutiny because of assumed low levels of annual emissions. Initiating with community complaints of nuisance from smoke, dust and odor, the Houston Department of Health and Human Services (HDHHS) began a monitoring program outside metal recycler facilities and found metal particulates in outdoor ambient air at levels which could pose a carcinogenic human health risk. In a study of five similar metal recycler facilities which used a torch cutting process, air downwind and outside the facility was sampled for eight hours between 6 and 10 times each over 18 months using a mobile laboratory. Ten background locations were also sampled. Iron, manganese, copper, chromium, nickel, lead, cobalt, cadmium and mercury were detected downwind of the metal recyclers at frequencies ranging from 100% of the time for iron to 2% of the time for mercury. Of these metals, chromium, nickel, lead, cobalt, cadmium and mercury were not detected in any sample in the background. Two pairs of samples were analyzed for total chromium and hexavalent chromium to establish a ratio of the fraction of hexavalent chromium in total chromium. This fraction was used to estimate hexavalent chromium at all locations. The carcinogenic risk posed to a residential receptor from metal particulate matter concentrations in the ambient air attributed to the metal recyclers was estimated from each of the five facilities in an effort to rank the importance of this source and inform the need for further investigation. The total risk from these area sources ranged from an increased cancer risk of 1 in 1,000,000 to 6 in 10,000 using the 95th upper confidence limit of the mean of the carcinogenic metal particulate matter concentration, assuming the point of the exposure is the sample location for a residential receptor after accounting for wind direction and the number of shifts that could operate a year. Further study is warranted to better understand the metal air pollution levels in the community and if necessary, to evaluate the feasibility of emission controls and identify operational improvements and best management practices for this industry. This research adds two new aspects to the literature: identification of types and magnitude of metal particulate matter air pollutants associated with a previously unrecognized area source, metal recyclers and their potential risk to health. -- Highlights: • Air monitoring study in response to community complaints found metal contamination. • Metal recyclers found to potentially pose cancer from metal particulates • Chromium, nickel, cobalt and cadmium samples were detected in five metal recyclers. • These metals were not detected in background air samples. • Estimated increased cancer risk ranges from 1 in 1,000,000 to 8 in 10,000.

Raun, Loren, E-mail: raun@rice.edu [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States)] [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States); Pepple, Karl, E-mail: pepple.karl@epa.gov [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States)] [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States); Hoyt, Daniel, E-mail: hoyt.daniel@epa.gov [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States)] [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States); Richner, Donald, E-mail: Donald.Richner@houstontx.gov [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States); Blanco, Arturo, E-mail: arturo.blanco@houstontx.gov [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States); Li, Jiao, E-mail: jiao.li@rice.edu [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)] [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)

2013-07-15T23:59:59.000Z

208

Thyroid cancer around Chernobyl  

SciTech Connect (OSTI)

The author`s presentation on thyroid cancer around Chernobyl will focus on four different things. First will be the time trends, or the pattern of thyroid cancer occurrence before and after the accident. It is now very well known that the increase in thyroid cancer in children in several areas has been unprecedented. Second, the author discusses thyroid cancer in general and patterns of thyroid cancer around the world before the Chernobyl accident, including differences by age and pathology. Third, the author presents relatively crude analyses of risk according to dose to the thyroid gland. And last, the author attempts to contrast the findings for thyroid cancer in relation to the internal radioiodine dose in Chernobyl studies with analyses of the effects of external dose on thyroid cancer incidence. The bottom line to be developed is similar to that presented by Elaine Ron with regard to effects of external dose on thyroid cancer. The similarities between the childhood finding from Chernobyl studies and external radiation studies appear more remarkable than the differences.

Beral, V. [Univ. of Oxford (United Kingdom)

1997-03-01T23:59:59.000Z

209

secondary ion detection | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ion detection secondary ion detection Leads No leads are available at this time. Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. Abstract: As a...

210

QUESTIONS & ANSWERS ABOUT LUNG CANCER  

E-Print Network [OSTI]

QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

211

Improving Lives. Improving Texas. Agency Strategic Plan  

E-Print Network [OSTI]

. Williams Administration Building 7101 TAMU September 2009 College Station, TX 77843-7101 Phone: 979. In the context of this broad mission, the priorities for Extension education are: Ensure a sustainable and management. Build local capacity for economic development in Texas communities. Improve the health

212

HMGA2 Participates in Transformation in Human Lung Cancer  

Science Journals Connector (OSTI)

...expression of abnormal HMGA2 fusion proteins. Interestingly, the...Overexpression of HMGA2-LPP fusion transcripts promotes expression...Kleeberger W, von Wasielewski HF, Kreipe H. Detection of gene...archival breast cancer specimens by laser-assisted microdissection and...

Francescopaolo Di Cello; Joelle Hillion; Alexandra Hristov; Lisa J. Wood; Mita Mukherjee; Andrew Schuldenfrei; Jeanne Kowalski; Raka Bhattacharya; Raheela Ashfaq; and Linda M.S. Resar

2008-05-01T23:59:59.000Z

213

Discrete Packet Analysis for Improved Atmospheric Rejection on Modulated Laser Signals  

SciTech Connect (OSTI)

This slide-show discusses how the method of discrete packet analysis improves atmospheric compensation for quasi-CW fluorescence detection methods. This is key to improving remote sensing capabilities.

O'Neill, M., McKenna, I., DiBenedetto, J., Capelle, G., Trainham, R.

2012-07-19T23:59:59.000Z

214

Cough Detection and Forecasting for Radiation Treatment of Lung Cancer.  

E-Print Network [OSTI]

??In radiation therapy, a treatment plan is designed to make the delivery of radiation to a target more accurate, effective, and less damaging to surrounding… (more)

Qiu, Zigang Jimmy

2010-01-01T23:59:59.000Z

215

Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers  

Science Journals Connector (OSTI)

Sarkar, P.; Ghosh, D.; Bhattacharyay, D.; Setford, S. J.; Turner, A. P. F.Electrochemical Immunoassay for Free Prostate Specific Antigen (f-PSA) Using Magnetic Beads Electroanalysis 2008, 20, 1414– 1420 ... Sarkar, P.; Ghosh, D.; Bhattacharyay, D.; Setford, S. J.; Turner, A. P. F. ...

Bhaskara V. Chikkaveeraiah; Ashwinkumar A. Bhirde; Nicole Y. Morgan; Henry S. Eden; Xiaoyuan Chen

2012-07-27T23:59:59.000Z

216

Dynamic fluorescence imaging with molecular agents for cancer detection  

E-Print Network [OSTI]

emission computed tomography SUV standard uptake values SLN sentinel lymph node TK tyrosine kinase TBR target to background ratio Symbols ? pharmacokinetic parameter ? pharmacokinetic parameter )(tC BOUND concentration of dye... bound to integrin receptor either in the vascular or extravascular compartments )(tC LAREXTRAVASCU concentration of dye in extravascular space )(tC VASCULAR concentration of dye in vascular space 0 I background fluorescence intensity c k...

Kwon, Sun Kuk

2009-05-15T23:59:59.000Z

217

Detection of skin cancer Section for Cognitive Systems  

E-Print Network [OSTI]

, Technical University of Denmark for EOD HCI systems extraction of meaningful and actionable information.imm.dtu.dk 06/11/20093 DTU Informatics, Technical University of Denmark for EOD HCI systems extraction

218

Prevalidation of Salivary Biomarkers for Oral Cancer Detection  

Science Journals Connector (OSTI)

...a pathologist. Experimental handling procedures were randomized across the clinical...digoxigenin-labeled cRNA was hybridized to Applied Biosystems Human Genome Survey...probably intrinsic to microarray technology, but the effect can be minimized...

David Elashoff; Hui Zhou; Jean Reiss; Jianghua Wang; Hua Xiao; Bradley Henson; Shen Hu; Martha Arellano; Uttam Sinha; Anh Le; Diana Messadi; Marilene Wang; Vishad Nabili; Mark Lingen; Darly Morris; Timothy Randolph; Ziding Feng; David Akin; Dragana A. Kastratovic; David Chia; Elliot Abemayor; and David T.W. Wong

2012-04-01T23:59:59.000Z

219

Detecting and molecular profiling cancer cells in patients  

E-Print Network [OSTI]

Although tumor cells obtained from human patients by surgical biopsy, image-guided intervention, blood draws or fluid drainage (paracentesis, thoracentesis) are a valuable source for analyzing tumor cells, conventional ...

Peterson, Vanessa M. (Vanessa Marie)

2013-01-01T23:59:59.000Z

220

Inhibiting Individual Notch Receptors Improves Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Inhibiting Individual Notch Inhibiting Individual Notch Receptors Improves Treatment Inhibiting Individual Notch Receptors Improves Treatment Print Wednesday, 27 July 2011 00:00 Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Inhibiting Individual Notch Receptors Improves Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

222

Inhibiting Individual Notch Receptors Improves Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

223

Inhibiting Individual Notch Receptors Improves Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

224

Agricultural Improvement Loan Program  

Broader source: Energy.gov [DOE]

The Agricultural Improvement Loan Program is administered by the Minnesota Department of Agriculture through the Minnesota Rural Finance Authority (RFA) and provides loans to farmers for...

225

HUD Home Improvements  

Broader source: Energy.gov [DOE]

Provides a collection of information, resources, and updates related to home improvements and insurance for manufactured housing. Author: U.S. Department of Housing and Urban Development

226

E-Print Network 3.0 - ar-negative prostate cancers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer Summary: --22000000 58 Prostate cancer Prostate cancer...

227

Evidence That New Hypnotics Cause Cancer  

E-Print Network [OSTI]

medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

Kripke, Daniel F.

2008-01-01T23:59:59.000Z

228

GE Cancer Research | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technology "Relay Race" Against Cancer Technology "Relay Race" Against Cancer To commemorate National Cancer Research Month, eight researchers joined together in a technology...

229

A Targeted Cancer Treatment using Nanomaterials | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

When Roots Follow the Path of Least Resistance When Roots Follow the Path of Least Resistance Perfecting Catalytic Arrays A Stable Open Framework with Wide Open Spaces Pumping Through the Middle Crust Looking for Ways to Improve Vaccines Against the Deadly Rotavirus Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Targeted Cancer Treatment using Nanomaterials AUGUST 27, 2009 Bookmark and Share Optical fluorescent imaging of the TiO2-mAb binding to the single brain cancer cells. The bare titianium dioxide nanoparticle bonds with an antibody and attaches itself to brain cancer cells. When exposed to concentrated white light, the titanium dioxide creates free radicals of oxygen that cause the cancer cells to die. Image courtesy of Argonne

230

Epirubicin and Cyclophosphamide, Methotrexate, and Fluorouracil as Adjuvant Therapy for Early Breast Cancer  

Science Journals Connector (OSTI)

...therapy. In the Early Breast Cancer/Mammary5 (EBC-1/MA.5) study by the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG), which compared a combination of cyclophosphamide, epirubicin, and fluorouracil (CEF) with CMF alone in premenopausal women with node-positive breast cancer, the rate... In women with early breast cancer, adjuvant therapy with epirubicin plus the standard combination of cyclophosphamide, methotrexate, and fluorouracil (CMF) was shown to improve both relapse-free and overall survival, as compared with the standard CMF regimen alone.

Poole C.J.; Earl H.M.; Hiller L.

2006-11-02T23:59:59.000Z

231

Effective Conveyor Belt Inspection for Improved Mining Productivity  

SciTech Connect (OSTI)

This document details progress on the project entitled ''Effective Conveyor Belt Inspection for Improved Mining Productivity'' during the period from November 15, 2004 to May 14, 2004. Highlights include fabrication of an improved LED lightbar, fabrication of a line-scan sensor head for the Smart-Camera based prototype, and development of prototype vulcanized splice detection algorithms.

Chris Fromme

2006-06-01T23:59:59.000Z

232

Open problem: Dynamic Relational Models for Improved Hazardous Weather Prediction  

E-Print Network [OSTI]

. Current weather radar detection and prediction sys- tems primarily rely on numerical models. We proposeOpen problem: Dynamic Relational Models for Improved Hazardous Weather Prediction Amy McGovern1, #12;Dynamic Relational Models for Improved Hazardous Weather Prediction Radar velocity Radar

McGovern, Amy

233

High sensitivity leak detection method and apparatus  

DOE Patents [OSTI]

An improved leak detection method is provided that utilizes the cyclic adsorption and desorption of accumulated helium on a non-porous metallic surface. The method provides reliable leak detection at superfluid helium temperatures. The zero drift that is associated with residual gas analyzers in common leak detectors is virtually eliminated by utilizing a time integration technique. The sensitivity of the apparatus of this disclosure is capable of detecting leaks as small as 1.times.10.sup.-18 atm cc sec.sup.-1.

Myneni, Ganapatic R. (Grafton, VA)

1994-01-01T23:59:59.000Z

234

High sensitivity leak detection method and apparatus  

DOE Patents [OSTI]

An improved leak detection method is provided that utilizes the cyclic adsorption and desorption of accumulated helium on a non-porous metallic surface. The method provides reliable leak detection at superfluid helium temperatures. The zero drift that is associated with residual gas analyzers in common leak detectors is virtually eliminated by utilizing a time integration technique. The sensitivity of the apparatus of this disclosure is capable of detecting leaks as small as 1 [times] 10[sup [minus]18] atm cc sec[sup [minus]1]. 2 figs.

Myneni, G.R.

1994-09-06T23:59:59.000Z

235

Aneuploidy: Cancer's Fatal Flaw?  

E-Print Network [OSTI]

Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

Williams, Bret R.

236

Targeting Cancer Metabolism  

Science Journals Connector (OSTI)

...oncogene drives the increase in cellular biomass facilitating proliferation. PKM2 expression...many human cancers stimulating cellular biomass accumulation (see review by Miller and...oncogene drives the increase in cellular biomass facilitating proliferation. PKM2 expression...

Beverly A. Teicher; W. Marston Linehan; Lee J. Helman

2012-10-15T23:59:59.000Z

237

Radiation Induced Mammary Cancer  

Science Journals Connector (OSTI)

......Induced Mammary Cancer R.L. Ullrich * R.J. Preston # * Department of Radiation Therapy, University of Texas Medical Branch, Galveston, TX 77550 # Biology Division Oak Ridge National Laboratory Oak Ridge, TN 37831, U.S.A Over the last......

R.L. Ullrich; R.J. Preston

1991-12-01T23:59:59.000Z

238

Fecal DNA versus Fecal Occult Blood for Colorectal-Cancer Screening in an Average-Risk Population  

Science Journals Connector (OSTI)

Colorectal cancer is the second leading cause of death from cancer among adults. Despite recommendations endorsing screening, less than 40 percent of people 50 years of age or older undergo screening for colorectal cancer. Guaiac-based chemical detection of fecal occult blood is the only... This prospective study of asymptomatic people 50 years of age or older compared a fecal DNA panel with a fecal occult-blood test (Hemoccult II) for colorectal-cancer screening. Colonoscopy was the reference standard. The fecal DNA panel detected 52 percent of cancers, whereas Hemoccult II detected only 13 percent. The sensitivity of the fecal DNA panel for any advanced neoplasia was 18 percent, as compared with 11 percent for Hemoccult II. The two tests had similar specificity.

Imperiale T.F.Ransohoff D.F.Itzkowitz S.H.Turnbull B.A.Ross M.E.

2004-12-23T23:59:59.000Z

239

Improved wire chamber  

DOE Patents [OSTI]

An improved gas mixture for use with proportional counter devices, such as Geiger-Mueller tubes and drift chambers. The improved gas mixture provides a stable drift velocity while eliminating wire aging caused by prior art gas mixtures. The new gas mixture is comprised of equal parts argon and ethane gas and having approximately 0.25% isopropyl alcohol vapor. 2 figs.

Atac, M.

1987-05-12T23:59:59.000Z

240

Improved solid aerosol generator  

DOE Patents [OSTI]

An improved solid aerosol generator used to produce a gas borne stream of dry, solid particles of predetermined size and concentration. The improved solid aerosol generator nebulizes a feed solution of known concentration with a flow of preheated gas and dries the resultant wet heated aerosol in a grounded, conical heating chamber, achieving high recovery and flow rates. 2 figs.

Prescott, D.S.; Schober, R.K.; Beller, J.

1988-07-19T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Less Yin, More Yang: Confronting the Barriers to Cancer Immunotherapy  

Science Journals Connector (OSTI)

...136-46. 14 Lizee G, Radvanyi LG, Overwijk WW, Hwu P. Immunosuppression in melanoma...Cancer Res 2001;61:6451-8. 44 Overwijk WW, Theoret MR, Finkelstein SE, et...207-14. 62 Lizee G, Radvanyi LG, Overwijk WW, Hwu P. Improving antitumor immune...

Gregory Lizée; Mayra A. Cantu; Patrick Hwu

2007-09-15T23:59:59.000Z

242

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer  

E-Print Network [OSTI]

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

Weber, David J.

243

Measurement, Analysis, and Improvement  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

6 Measurement, Analysis, and Improvement Process 11_0304 Page 1 of 6 6 Measurement, Analysis, and Improvement Process 11_0304 Page 1 of 6 EOTA - Business Process Document Title: Measurement, Analysis, and Improvement Process Document Number: P-006 Rev 11_0304 Document Owner: Elizabeth Sousa Backup Owner: Melissa Otero Approver(s): Melissa Otero Parent Document: Q-001, Quality Manual Notify of Changes: EOTA Employees Referenced Document(s): P-008 Corrective-Preventive Action Process, P-004 Business System Management Review and REG-003 Records Register P-006 Measurement, Analysis, and Improvement Process 11_0304 Page 2 of 6 Revision History: Rev. Description of Change A Initial Release 08_0416 Changed verbiage in Step 6 to, "CAR/PAR/IO using P-008, Corrective-Preventive Action & Improvement Opportunity"

244

Milestone Plan Process Improvement  

Broader source: Energy.gov (indexed) [DOE]

Milestone Plan Process Improvement Milestone Plan Process Improvement Milestone Plan Process Improvement Background In response to our community's concern over the milestone plan (MP) process within the system, the STRIPES Project Office initiated an in-depth evaluation of the required steps and issues surrounding this process. We concluded that the MP process could be improved for most users by tuning the system configuration. With the approval of both the STRIPES Executive Steering Committee and the STRIPES Project Office, we launched the MP Process Improvement Initiative. After many meetings with members of the STRIPES Team and Working Group, we are ready to "go-live" with this initiative. On October 1 st , 2012 the new MP process will be implemented for use by most field offices.

245

The Influence of Increased Ambient Lighting on Mass Detection in Mammograms  

Science Journals Connector (OSTI)

Rationale and Objectives Recent research has provided evidence that in reading rooms equipped with liquid crystal displays (LCDs), a measured increase of ambient lighting may improve clinicians' detection performance. In agreement with this research, the American College of Radiology (ACR) has recommended a moderate increase of ambient lighting in mammography reading rooms. This study was designed to examine the effect of a controlled increase of ambient lighting in mammography reading rooms on the diagnostic performance of breast imaging radiologists. Materials and Methods Four breast imaging radiologists read 86 mammograms (43 containing subtle cancerous masses and 43 normal) under low (E = 1 lux) and elevated (E = 50 lux) ambient lighting levels on a Digital Imaging and Communications in Medicine–calibrated, medical-grade LCD. Radiologists were asked to identify cancerous masses and to rate their detection confidence. Observer areas under the curve (AUCs) were calculated using a receiver-operating characteristic analysis of fully paired results. Additionally, average observer selection times under both ambient lighting levels were determined. Results Average radiologist \\{AUCs\\} decreased with elevated ambient lighting (0.78 ± 0.03 to 0.72 ± 0.04). Observer performance differences, however, were of the same order of magnitude as interobserver variability and were not statistically significant. Average selection times under increased ambient lighting remained constant or decreased, with the greatest decrease occurring for false-positive (20.4 ± 18.9 to 14.4 ± 9.6 seconds) and true-positive (18.0 ± 13.8 to 12.9 ± 9.4 seconds) selections. Conclusion The results agree with those of previous studies in that observer performance differences under a controlled increase of ambient lighting are not statistically significant. On the basis of these findings and ACR guidelines, a moderate increase of ambient lighting in mammography reading rooms is still suggested, but further research with additional cases and observers should be considered.

Benjamin J. Pollard; Ehsan Samei; Amarpreet S. Chawla; Jay Baker; Sujata Ghate; Connie Kim; Mary S. Soo; Noriyuki Hashimoto

2009-01-01T23:59:59.000Z

246

Revolution in Detection Affairs  

SciTech Connect (OSTI)

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

Stern W.

2013-11-02T23:59:59.000Z

247

Object Detection Combining Recognition and Segmentation  

E-Print Network [OSTI]

segmentation. There are two main steps in this method: a hypothesis generation step and a verification step. In the top-down hy- pothesis generation step, we design an improved Shape Context feature, which is more. We develop an object detection method combining top-down recog- nition with bottom-up image

Plotkin, Joshua B.

248

Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer  

E-Print Network [OSTI]

of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, California populations. Our mathematical model predicts the population dynamics of mixtures of sensitive and resistant

249

More Rapid Detection of Strontium in Urine Samples (IN-10-037...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

More Rapid Detection of Strontium in Urine Samples (IN-10-037) New and Improved Detection Method that Provides More Rapid and Accurate Identification of Sr-90 in Urine Samples...

250

Improved Dragline Utilization  

E-Print Network [OSTI]

The cause of energy conservation can be served by increasing the efficiency of large draglines used in surface coal mining. The topic is the application of a training simulator, computer instrumentation and computer simulation to improve dragline...

Keller, K. J.

1980-01-01T23:59:59.000Z

251

Improving Project Management  

Broader source: Energy.gov [DOE]

On December 19, 2014, the Energy Department released its "Improving Project Management" report, a roadmap to transformation in funding, culture, project ownership, independent oversight and front-end planning from experienced project management leaders.

252

Single-Molecule Detection  

Science Journals Connector (OSTI)

Detection of single molecules represents the ultimate level of sensitivity and ... background, fluorescence is one obvious choice for single-molecule detection (SMD). However, SMD using ... first report on SMD us...

2006-01-01T23:59:59.000Z

253

Cell Senescence: Aging and Cancer  

ScienceCinema (OSTI)

Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

Campisi, Judith

2013-05-29T23:59:59.000Z

254

Emerging Nanomedicine for Skin Cancer  

Science Journals Connector (OSTI)

Skin cancer is a common cancer and is associated with significant morbidity and mortality. Topical treatment is an attractive option compared with systemic route due to the reduced association with systemic to...

Puiyan Lee; Adnan Nasir; Kenneth K. Y. Wong

2013-01-01T23:59:59.000Z

255

OVARIAN CANCER GENE THERAPY  

Science Journals Connector (OSTI)

Although systemic gene therapy is certainly the ultimate goal for strategies directed towards patient cancer therapy, present problems with systemic vector delivery suggest that initial gene therapy strategies may involve regional approaches directed towards the few specific tumors that exhibit a predominantly regional pattern of spread: ovarian cancers and brain tumors. The model system of metastatic ovarian cancer growing within peritoneal fluid has several advantages of safety and efficacy for retroviral-mediated gene transfer into solid tumors. First, the pathology of metastasis into mesothelial-lined spaces consists of relatively thin tumor plaques with extravasation of cancer cells into the fluid, potentially allowing a reservoir for delivering retroviral vectors to malignant cells. This spreading pattern is in contrast to primary tumors and more solid metastatic sites, where cancer grows as a large three-dimensional mass that could prevent delivery of retroviral vectors or other agents into the majority of tumor cells. In addition, infusion of retroviral vectors into these fluids should produce a greater effect on the growing cells within the fluid (predominantly cancer cells) than on proliferating host cells in regions of the body that do not directly connect to the mesothelial-lined spaces. Second, ovarian cancer provides a model system in which regional therapy could be curative in a high percentage of cases. This is true because ovarian cancer is confined to the peritoneal cavity at patient presentation in 60% of cases. The uptake and expression of the viral vectors can be readily assessed in these model systems because these fluids are readily accessible for cytologic, biochemical, and molecular analysis. Cancer gene therapy strategies include immunotherapy, introduction of drug sensitivity or resistance genes, oncogene inactivation, introduction of cytolytic genes, and tumor suppressor gene replacement. Examples of gene therapy protocols designed to target ovarian cancer include immunotherapy approaches, introduction of cytolytic genes, and tumor suppressor gene therapy approaches (reviewed in Roth and Cristiano22). The BRCA1 gene is mutated in the majority of cases of hereditary breast and ovarian cancer and exhibits loss of heterozygosity (LOH) and/or decreased expression in many sporadic cases.5,6,7,9,11,16,17,30,31 Multiple studies have demonstrated that overexpression of the BRCA1 gene results in growth inhibition and/or cell death, suggesting that BRCA1 can function directly as a growth inhibitor or tumor suppressor.10,21,28,31,33,34 Alternatively, growth inhibition may not be the major or sole mechanism for tumor suppression,13 because BRCA1 also functions during differentiation8,14,15 and may modulate DNA repair.13,27 The antitumor effect may be due to secretion of the BRCA1 gene product and a resulting paracrine inhibitory effect,12 although the precise biochemical function of BRCA1 is controversial and may involve nuclear functions4,26 such as DNA repair27 or transcriptional activation.3,18 Preclinical studies in nude mice xenografts have shown that intraperitoneal injection of retroviral vectors expressing \\{BRCA1sv\\} (a normal splice variant form of BRCA1) can inhibit the growth of established intraperitoneal tumors.10 Control retroviral vectors do not exhibit a significant antitumor effect, indicating that this is not merely a nonspecific effect of retroviral injection, but an effect of BRCA1 gene transfer.10 These studies showed transduction of tumor cells and expression of BRCA1 mRNA and protein following intraperitoneal injection of established intraperitoneal tumors10 or intratumoral injection of subcutaneous tumors (Obermiller and Holt, unpublished data). This article describes the development and phase I testing of BRCA1 gene therapy for the treatment of ovarian cancer.

David L. Tait; Patrice S. Obermiller; Roy A. Jensen; Jeffrey T. Holt

1998-01-01T23:59:59.000Z

256

Hindawi Publishing Corporation Prostate Cancer  

E-Print Network [OSTI]

Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

Ahn, Hongshik

257

Biological Research in the Evolution of Cancer Surgery: A Personal Perspective  

Science Journals Connector (OSTI)

...resulting from engineering research have improved...Centuries) The history of cancer surgery...alter the natural history of patients with...occurring, research in engineering was making feasible...resulting from engineering research have improved...General Surgery history History, 19th...

Bernard Fisher

2008-12-15T23:59:59.000Z

258

Abstract B26: Developing a community health educator (CHE) intervention model for identifying unmet needs and assessing behavioral change with tailored health education for breast and colorectal cancer patients after cancer treatment  

Science Journals Connector (OSTI)

...Behavioral and Social Science Health Education: Poster Presentations - Proffered Abstracts...for technology-based cancer education for Latina women from an agricultural...technology-driven health education programs improve on passive communication...

Bonnie Schwartzbauer; Kevin Fiscella; Starlene Loader; and Sally Rousseau

2010-10-01T23:59:59.000Z

259

Radiation prevents much cancer  

Science Journals Connector (OSTI)

Evidence reviewed here supports the concept that chronic exposure to ionising radiation can dramatically decrease cancer incidence and mortality. This evidence includes an inverse relationship between radiation levels and cancer induction and/or mortality in: over 200 million people in the USA; 200 million people in India; 10,000 residents of Taipei who live in cobalt-60 contaminated homes; high radiation areas of Ramsar, Iran; 12 million person-years of exposed and carefully selected control nuclear workers; almost 300,000 homes with radon in the USA; non-smokers in high radon areas of Saxony, Germany.

T.D. Luckey

2007-01-01T23:59:59.000Z

260

Hands-on resonance-enhanced photoacoustic detection  

Science Journals Connector (OSTI)

The design of an improved photoacoustic converter cell using kitchen equipment is described. It operates by changing manually the Helmholtz resonance frequency of bottles by adjusting the distance between the bottleneck and the outer ear. The experiment helps to gain insights in ear performance in photoacoustic detection methods in resonance phenomena and their role for detecting small periodic signals in the presence of noise.

Manfred Euler

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

A Review of NCI's Extramural Grant Portfolio: Identifying Opportunities for Future Research in Genes and Environment in Cancer  

Science Journals Connector (OSTI)

...NIEHS's 2012-2017 Strategic Plan (23), and the NIH GEI...Sciences 2012-2017 Strategic Plan-Advancing Science, Improving Health: A Plan for Environmental Health Research...American Cancer Society; 2012. A Review of NCI's Extramural Grant...

Armen A. Ghazarian; Naoko I. Simonds; Kelly Bennett; Camilla B. Pimentel; Gary L. Ellison; Elizabeth M. Gillanders; Sheri D. Schully; and Leah E. Mechanic

2013-04-01T23:59:59.000Z

262

High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates  

Science Journals Connector (OSTI)

...4 Department of Biomedical Engineering, Boston University, Boston...and Department of Biomedical Engineering, Rutgers University, Piscataway...subtype with an improved natural history. [Cancer Res 2007;67...any differences in natural history among these tumors is likely...

Gabriela Alexe; Gul S. Dalgin; Daniel Scanfeld; Pablo Tamayo; Jill P. Mesirov; Charles DeLisi; Lyndsay Harris; Nicola Barnard; Maritza Martel; Arnold J. Levine; Shridar Ganesan; and Gyan Bhanot

2007-11-15T23:59:59.000Z

263

Abstract A44: Feasibility study for technology-based cancer education for Latina women from an agricultural community  

Science Journals Connector (OSTI)

...Behavioral and Social Science Health Education: Poster Presentations - Proffered Abstracts...for technology-based cancer education for Latina women from an agricultural...technology-driven health education programs improve on passive communication...

Laura E. Barnes; Maria Rivera; Cathy D. Meade; Sara K. Proctor; Liliana M. Gutierrez; and Kristen J. Wells

2011-09-01T23:59:59.000Z

264

Abstract A32: Tackling cancer health disparities through science, training, and community: Generating new knowledge through continuing education  

Science Journals Connector (OSTI)

...Behavioral and Social Science Health Education: Poster Presentations - Proffered Abstracts...behavioral change with tailored health education for breast and colorectal cancer...treatment. Tailoring health education to patient needs may improve...

Cathy D. Meade; Clement K. Gwede; Shalewa Noel-Thomas; Shalanda Bynum; Chrystyna Pospolyta; Cindy Burcham; and Mariana Arevalo

2010-10-01T23:59:59.000Z

265

Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)  

E-Print Network [OSTI]

of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece and 19Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands Email: Federico Canzian* - f.canzian@dkfz.de; Rudolf Kaaks - r... ; Inter- national Agency for Research on Cancer, Lyon, France) using a fluorescent 5' endonuclease assay and the ABI- PRISM 7900 for sequence detection (TaqMan). Initial quality control checks of the SNP assays were performed by the manufacturer (Applied...

Canzian, Federico; Kaaks, Rudolf; Cox, David G; Henderson, Katherine D; Henderson, Brian E; Berg, Chrsitine; Bingham, Sheila; Boeing, Heiner; Buring, Julie; Calle, Eugenia E; Chanock, Stephen J; Clavel-Chapelon, Francoise; Dossus, Laure; Spencer Feigelson, Heather; Haiman, Christopher A; Hankinson, Susan E; Hoover, Robert; Hunter, David J; Isaacs, Claudine; Lenner, Per; Lund, Eiliv; Overvad, Kim; Palli, Domenico; Pearce, Celeste Leigh; Quiros, Jose R; Riboli, Elio; Stram, Daniel O; Thomas, GIlles; Thun, Michael J; Trichopoulos, Dimitrios; van Gils, Carla H; Ziegler, Regina G

2009-07-29T23:59:59.000Z

266

Surveillance Guides - Continous Improvement  

Broader source: Energy.gov (indexed) [DOE]

CONTINUOUS IMPROVEMENT CONTINUOUS IMPROVEMENT 1.0 Objective The objective of this surveillance is to verify that contractor personnel are effectively managing environment, safety, and health issues in a manner that fosters continuous improvement. The activities included in this surveillance help the Facility Representative determine whether safety issues identified through internal contractor, and external DOE or Defense Nuclear Facilities Safety Board evaluation programs are resolved consistent with the level of safety importance. 2.0 References 2.1 DOE O 414.1, Quality Assurance 2.2 DOE O 232.1, Occurrence Reporting and Processing of Operations Information 2.3 DOE-STD-1045-93, Guide to Good Practices for Notifications and Investigations of Abnormal Events 2.4 48 CFR 1970.5204, Department of Energy Acquisition

267

Improving steam turbine efficiency  

SciTech Connect (OSTI)

This paper describes the condition of a significant number of fossil steam turbines operating in the United States and the maintenance practices used to improve their performance. Through the use of steam path audits conducted by the authors` company and by several utilities, a large data base of information on turbine heat rate, casing efficiency, and maintenance practices is available to help the power generation industry understand how different maintenance practices and steam path damage impact turbine performance. The data base reveals that turbine cycle heat rate is typically 5.23% poorer than design just prior to major outages. The degraded condition of steam turbines presents an opportunity for utilities to improve heat rate and reduce emissions without increasing fuel costs. The paper describes what losses typically contribute to the 5.23% heat rate degradation and how utilities can recover steam turbine performance through maintenance actions aimed at improving steam path efficiency.

Cioffi, D.H.; Mitchell, D.R.; Whitecar, S.C. [Encotech, Inc., Schenectady, NY (United States)

1995-06-01T23:59:59.000Z

268

OIT geothermal system improvements  

SciTech Connect (OSTI)

The Oregon Institute of Technology campus has been heated by the direct use of geothermal fluids since 1964. The 11 building campus uses geothermal energy for space heating/cooling, domestic water heating, the swimming pool and sidewalk snow melt. The hydronic system was designed to use the geothermal fluids directly in heating units. In the 1970s, problems were experienced with the design and operation of the well pumps, buried piping and heating equipment. Beginning in the early 1980`s, many improvements were made to the system due to equipment performance problems and resource management requirements. This paper discusses those improvements that included the distribution system, cooling, well pumps, cascading of geothermal fluids, installation of isolation plate heat exchangers in each building and drilling of two injection wells. Plans for future improvements include better controls to manage energy use and data monitoring systems for individual buildings, and instrumentation to monitor well pump performance.

Lienau, P.J.

1996-12-31T23:59:59.000Z

269

ACCELERATED IMPROVEMENT A CONCENTRATED APPROACH  

E-Print Network [OSTI]

ACCELERATED IMPROVEMENT A CONCENTRATED APPROACH FOR CONTINUOUS IMPROVEMENT #12;Accelerated.quality.wisc.edu O F F I C E O F Q U A L I T Y I M P R O V E M E N T Accelerated Improvement This guide to improving resources. You will find helpful information needed to conduct an Accelerated Improvement project

Shapiro, Vadim

270

Improved vortex reactor system  

DOE Patents [OSTI]

An improved vortex reactor system for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor.

Diebold, James P. (Lakewood, CO); Scahill, John W. (Evergreen, CO)

1995-01-01T23:59:59.000Z

271

CAMPUS IMPROVEMENT PROGRAM 201420  

E-Print Network [OSTI]

(CIP) 2014­20? The Campus Improvement Program (CIP) is a concept proposal for the delivery of new-Darlington campus to 2020 through land uses and building envelopes. The CIP is not a proposal for the detailed design and construction of new buildings. See point 9. 2. What are the objectives of the CIP? The CIP

Viglas, Anastasios

272

Abstract A33: Exploring pediatric cancer genomics with the UCSC Cancer Genomics Browser  

Science Journals Connector (OSTI)

...October 2014 meeting-abstract Pediatric Cancer Genomics and Epigenomics Pediatric Cancer Genomics and Epigenomics: Poster Presentations - Proffered...Abstract A33: Exploring pediatric cancer genomics with the UCSC Cancer Genomics Browser Melissa...

Melissa Cline; Olena Morozova; Teresa Swatloski; Brian Craft; Mary Goldman; David Haussler; Jingchun Zhu

2014-10-15T23:59:59.000Z

273

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer  

E-Print Network [OSTI]

Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

2006-01-01T23:59:59.000Z

274

ORISE: Peer Review Process Improvement  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Process Improvement Two men discuss ways to improve peer review processes After finding academic reviewers and conducting peer reviews, the Oak Ridge Institute for Science and...

275

Improved gaseous leak detector  

DOE Patents [OSTI]

In a short path length mass-spectrometer type of helium leak detector wherein the helium trace gas is ionized, accelerated and deflected onto a particle counter, an arrangement is provided for converting the detector to neon leak detection. The magnetic field of the deflection system is lowered so as to bring the nonlinear fringe area of the magnetic field across the ion path, thereby increasing the amount of deflection of the heavier neon ions.

Juravic, F.E. Jr.

1983-10-06T23:59:59.000Z

276

Think Detection. Think Prevention.  

E-Print Network [OSTI]

Think Detection. Think Prevention. Think Activity. Office Ergonomics: #12;The Case of Mr. Z Mr. Z..........................................................................................7 Think Prevention. Ergonomics .............................................................11 What is office ergonomics?................................................................11 Making Your

Calgary, University of

277

EMSL - secondary ion detection  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

secondary-ion-detection en Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. http:www.emsl.pnl.govemslwebpublicationsmagnesium-behavior-and-struc...

278

Improving Floating Point Compression  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Improving Improving Floating Point Compression through Binary Masks Leonardo A. Bautista Gomez Argonne National Laboratory Franck Cappello Argonne National Laboratory Abstract-Modern scientific technology such as particle accel- erators, telescopes and supercomputers are producing extremely large amounts of data. That scientific data needs to be processed using systems with high computational capabilities such as supercomputers. Given that the scientific data is increasing in size at an exponential rate, storing and accessing the data is becoming expensive in both, time and space. Most of this scientific data is stored using floating point representation. Scientific applications executed in supercomputers spend a large amount of CPU cycles reading and writing floating point values, making data compression techniques an interesting way to increase computing efficiency.

279

Improved vortex reactor system  

DOE Patents [OSTI]

An improved vortex reactor system is described for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor. 12 figs.

Diebold, J.P.; Scahill, J.W.

1995-05-09T23:59:59.000Z

280

Planetary Nebulae Detection  

E-Print Network [OSTI]

layers develop deep convective zone, surface expands, mass loss due to stellar wind · Star moves from tip1 Planetary Nebulae · Detection · Distribution in the Galaxy · Central Stars · Evolution · Bipolar to dust) · Difficult to detect in radio (fainter than H II regions) · Projected number based on surveys

Crenshaw, Michael

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Array for detecting microbes  

DOE Patents [OSTI]

The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.

Andersen, Gary L.; DeSantis, Todd D.

2014-07-08T23:59:59.000Z

282

Circle based community detection  

Science Journals Connector (OSTI)

The connection patterns among individuals or objects in complex (social) networks possess rich information that can be useful for conducting effecient network analysis. In particular we consider the task of community detection in social networks. Nowadays ... Keywords: community detection, social networks

Hemank Lamba; Ramasuri Narayanam

2013-10-01T23:59:59.000Z

283

Fiber Optic Micro-endoscopy for Detection of Bacteria in Early Stages of Infection  

E-Print Network [OSTI]

. have built a wide field Light Emitting Diode (LED) illumination based, 1 mm diameter fiber bundle micro-endoscope capable of sub-cellular resolution imaging (4 ?m resolution with 750 ?m field of view) for pre-cancer detection in the oral mucosa [16.... have built a wide field Light Emitting Diode (LED) illumination based, 1 mm diameter fiber bundle micro-endoscope capable of sub-cellular resolution imaging (4 ?m resolution with 750 ?m field of view) for pre-cancer detection in the oral mucosa [16...

Mufti, Nooman Sadat

2012-02-14T23:59:59.000Z

284

Childhood Cancer Tracking Initiative in Massachusetts  

E-Print Network [OSTI]

Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

285

Cancer Therapies: A Bane and a Boon  

E-Print Network [OSTI]

on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

Neogi, Sushrita

2012-01-01T23:59:59.000Z

286

Diet, MicroRNAs and Prostate Cancer  

E-Print Network [OSTI]

deregulation in human cancer. Cell Cycle. 2008;7:2643–6. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

2010-01-01T23:59:59.000Z

287

Cancer genomics and the TCGA project  

Science Journals Connector (OSTI)

...Research September 15, 2011 meeting-abstract Cancer Genomics Cancer Genomics: Poster Presentations - Proffered Abstracts Abstracts...San Francisco, CA Abstract A39: The UCSC Cancer Genomics Browser Brian Craft 1 Kyle Ellrott 1 Mary Goldman...

David Haussler

2010-10-01T23:59:59.000Z

288

Heat induces gene amplification in cancer cells  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer This study discovered that heat exposure (hyperthermia) results in gene amplification in cancer cells. Black-Right-Pointing-Pointer Hyperthermia induces DNA double strand breaks. Black-Right-Pointing-Pointer DNA double strand breaks are considered to be required for the initiation of gene amplification. Black-Right-Pointing-Pointer The underlying mechanism of heat-induced gene amplification is generation of DNA double strand breaks. -- Abstract: Background: Hyperthermia plays an important role in cancer therapy. However, as with radiation, it can cause DNA damage and therefore genetic instability. We studied whether hyperthermia can induce gene amplification in cancer cells and explored potential underlying molecular mechanisms. Materials and methods: (1) Hyperthermia: HCT116 colon cancer cells received water-submerged heating treatment at 42 or 44 Degree-Sign C for 30 min; (2) gene amplification assay using N-(phosphoacetyl)-L-aspartate (PALA) selection of cabamyl-P-synthetase, aspartate transcarbarmylase, dihydro-orotase (cad) gene amplified cells; (3) southern blotting for confirmation of increased cad gene copies in PALA-resistant cells; (4) {gamma}H2AX immunostaining to detect {gamma}H2AX foci as an indication for DNA double strand breaks. Results: (1) Heat exposure at 42 or 44 Degree-Sign C for 30 min induces gene amplification. The frequency of cad gene amplification increased by 2.8 and 6.5 folds respectively; (2) heat exposure at both 42 and 44 Degree-Sign C for 30 min induces DNA double strand breaks in HCT116 cells as shown by {gamma}H2AX immunostaining. Conclusion: This study shows that heat exposure can induce gene amplification in cancer cells, likely through the generation of DNA double strand breaks, which are believed to be required for the initiation of gene amplification. This process may be promoted by heat when cellular proteins that are responsible for checkpoints, DNA replication, DNA repair and telomere functions are denatured. To our knowledge, this is the first study to provide direct evidence of hyperthermia induced gene amplification.

Yan, Bin, E-mail: yanbin@mercyhealth.com [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Mercy Cancer Center, Mercy Medical Center-North Iowa, Mason City, IA 50401 (United States); Ouyang, Ruoyun [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China)] [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China); Huang, Chenghui [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Department of Oncology, The Third Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410013 (China); Liu, Franklin [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States); Neill, Daniel [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States)] [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Li, Chuanyuan [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States)] [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States); Dewhirst, Mark [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)

2012-10-26T23:59:59.000Z

289

Cancer treatment: The killer within  

Science Journals Connector (OSTI)

... thus far have fared poorly, they may work synergistically with other immunotherapies, says Willem Overwijk, a cancer researcher at MD Anderson. ...

Heidi Ledford

2014-04-02T23:59:59.000Z

290

Neutron Detection with Mercuric Iodide  

SciTech Connect (OSTI)

Mercuric iodide is a high-density, high-Z semiconducting material useful for gamma ray detection. This makes it convertible to a thermal neutron detector by covering it with a boron rich material and detecting the 478 keV gamma rays resulting from the {sup 10}B(n, {alpha}){sup 7}Li* reaction. However, the 374 barn thermal capture cross section of {sup nat}Hg, makes the detector itself an attractive absorber, and this has been exploited previously. Since previous work indicates that there are no low-energy gamma rays emitted in coincidence with the 368 keV capture gamma from the dominant {sup 199}Hg(n, {gamma}){sup 200}Hg reaction, only the 368 keV capture gamma is seen with any efficiency a relatively thin (few mm) detector. In this paper we report preliminary measurements of neutrons via capture reactions in a bare mercuric iodide crystal and a crystal covered in {sup 10}B-loaded epoxy. The covered detector is an improvement over the bare detector because the presence of both the 478 and 368 keV gamma rays removes the ambiguity associated with the observation of only one of them. Pulse height spectra, obtained with and without lead and cadmium absorbers, showed the expected gamma rays and demonstrated that they were caused by neutrons.

Bell, Z.A.

2003-06-17T23:59:59.000Z

291

Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial–Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis  

Science Journals Connector (OSTI)

...21679006; and NEDO (New Energy and Industrial Technology...in cancer patients: challenges and perspectives.Trends...to routine diagnostic implementation?Eur J Cancer 2007...13:920-8. 7. Wind J , Tuynman JB, Tibbe...Pantel K.Biologic Challenges in the detection of...

Takehiko Yokobori; Hisae Iinuma; Teppei Shimamura; Seiya Imoto; Keishi Sugimachi; Hideshi Ishii; Masaaki Iwatsuki; Daisuke Ota; Masahisa Ohkuma; Takeshi Iwaya; Naohiro Nishida; Ryunosuke Kogo; Tomoya Sudo; Fumiaki Tanaka; Kohei Shibata; Hiroyuki Toh; Tetsuya Sato; Graham F. Barnard; Takeo Fukagawa; Seiichiro Yamamoto; Hayao Nakanishi; Shin Sasaki; Satoru Miyano; Toshiaki Watanabe; Hiroyuki Kuwano; Koshi Mimori; Klaus Pantel; and Masaki Mori

2013-04-01T23:59:59.000Z

292

Use of MRI fusion second-look ultrasound in breast cancer: can MRI US fusion reduce the need for MRI-guided biopsy?  

Science Journals Connector (OSTI)

Breast MRI is being increasingly used in breast cancer to look for extent of disease, in high-risk screening and in the dense breast. Frequently incidental lesions are detected on MRI that require second-look ult...

SE McWilliams

2012-11-01T23:59:59.000Z

293

Improved cycling cryopump  

DOE Patents [OSTI]

The present invention is designed to achieve continuous high efficiency cryopumping of a vacuum vessel by improving upon and combining in a novel way the cryopumping in a novel way the cryopumping methods. The invention consists of a continuous operation cryopump, with movable louvres, with a high efficiency pumping apparatus. The pumping apparatus includes three cryogenic tubes. They are constructed of a substance of high thermal conductivity, such as aluminum and their exterior surfaces are cryogenic condensing surfaces. Through their interior liquid or gaseous helium from two reservoirs can be made to flow, alternately promoting extreme cooling or allowing some warming.

Batzer, T.H.; Call, W.R.

1984-12-04T23:59:59.000Z

294

Colon Cancer Mapping | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Vanderbilt, GE Team Seek Deeper Understanding of Colon Cancer Vanderbilt, GE Team Seek Deeper Understanding of Colon Cancer Vanderbilt University has partnered with GE Global...

295

Laser research shows promise for cancer treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cancer treatment Laser research shows promise for cancer treatment Scientists have observed for the first time how a laser penetrates dense, electron-rich plasma to generate ions....

296

SKIN CANCER INSTITUTE THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE  

E-Print Network [OSTI]

SKIN CANCER INSTITUTE THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE Melanoma The Most Lethal Form advances in nanotechnology to increase our understanding of melanoma and to develop new tools into controllable cells or target them for destruction. Investigators also are using nanotechnology to understand

Engman, David M.

297

Apoptotic detection methods — from morphology to gene  

Science Journals Connector (OSTI)

To date, many terms have been given for cell death and forgotten before they became widely accepted. Most researchers studying cell death use some terms for cell death that have survived over centuries and regard apoptosis and programmed cell death (PCD), and necrosis and oncosis as synonymous. The different terminologies used for cell death depending on the preference of researchers sometimes cause confusion in the study of apoptosis. The study of apoptosis was first based on cell morphology using transmission electron microscopy (TEM): chromatin condensation, cellular shrinkage, budding and apoptotic body formation. Recently, marked progress in biochemistry, molecular biology and genetics provided researchers of apoptosis various tools for apoptotsis detection, such as the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end-labeling (TUNEL) method, agarose gel electrophoresis using extracted DNA, staining methods using fluorescence dyes, and flow cytometry. This review focuses on the following topics: history of the study of cell death and its classification, apoptosis-related proteins and their signal pathways, morphological, biochemical and molecular biological methods of apoptosis detection, and the transcriptional regulation of bcl-2 using the real-time Southwestern method and cancer gene therapy. In addition, the merits and demerits of the above-mentioned apoptosis detection methods are discussed.

Yoshinori Otsuki; Zhonglian Li; Masa-Aki Shibata

2003-01-01T23:59:59.000Z

298

Explosive Detection Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To standardize and accelerate implementation of the Department of Energy (DOE) explosive detection program. DOE N 251.40, dated 5/3/01, extends this directive until 12/31/01.

2000-10-26T23:59:59.000Z

299

Idaho Explosive Detection System  

ScienceCinema (OSTI)

Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

Klinger, Jeff

2013-05-28T23:59:59.000Z

300

Idaho Explosive Detection System  

SciTech Connect (OSTI)

Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

Klinger, Jeff

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Detection of counterfeit currency  

DOE Patents [OSTI]

A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.

Burns, Donald A. (Los Alamos, NM)

1998-01-01T23:59:59.000Z

302

Energy Detectives (3 Activities)  

K-12 Energy Lesson Plans and Activities Web site (EERE)

Students explore the classroom as they look and feel for signs of energy. They record the ways they use energy throughout a typical day in an energy detective journal.

303

Surface-engineered substrates for improved human pluripotent stem cell culture under  

E-Print Network [OSTI]

modification of typical cell culture plastics to define a favorable surface environment for human pluripotentSurface-engineered substrates for improved human pluripotent stem cell culture under fully defined of Chemical Engineering, d David H. Koch Institute for Integrative Cancer Research, and e Harvard

Saha, Krishanu

304

AACR Cancer Progress Report 2014  

Science Journals Connector (OSTI)

...which showed lesions in my brain. That and the history of thyroid...and, potentially, some with head and neck cancer (114, 115...associated and non-HPV-associated head and neck (H/N) cancer...translational perspective. Brain Behav Immun 2013;30(suppl...

Carlos L. Arteaga; Peter C. Adamson; Jeffrey A. Engelman; Margaret Foti; Richard B. Gaynor; Susan G. Hilsenbeck; Paul J. Limburg; Scott W. Lowe; Elaine R. Mardis; Scott Ramsey; Timothy R. Rebbeck; Andrea L. Richardson; Eric H. Rubin; George J. Weiner

2014-10-01T23:59:59.000Z

305

AACR Cancer Progress Report 2013  

Science Journals Connector (OSTI)

...Thus far, I've been spared, and I'm forever thankful to God and the wonderful care I received, and continue to receive...ixabepilone Ixempra Multiple cancers paclitaxel albumin-bound particles Abraxane Multiple cancers vinblastine Velban Certain leukemias...

Charles L. Sawyers; Cory Abate-Shen; Kenneth C. Anderson; Anna Barker; Jose Baselga; Nathan A. Berger; Margaret Foti; Ahmedin Jemal; Theodore S. Lawrence; Christopher I. Li; Elaine R. Mardis; Peter J. Neumann; Drew M. Pardoll; George C. Prendergast; John C. Reed; and George J. Weiner

2013-10-15T23:59:59.000Z

306

Breakthrough: Fighting Cancer with Nanoparticles  

ScienceCinema (OSTI)

Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

Rozhkova, Elena

2013-04-19T23:59:59.000Z

307

AACR Cancer Progress Report 2013  

Science Journals Connector (OSTI)

...generated $62.13 billion in new economic activity across the country...tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet...and LIVESTRONG. The global economic cost of cancer. American Cancer...impact/ 180. Ehrlich EM . An economic engine-NIH research, employment...

Charles L. Sawyers; Cory Abate-Shen; Kenneth C. Anderson; Anna Barker; Jose Baselga; Nathan A. Berger; Margaret Foti; Ahmedin Jemal; Theodore S. Lawrence; Christopher I. Li; Elaine R. Mardis; Peter J. Neumann; Drew M. Pardoll; George C. Prendergast; John C. Reed; and George J. Weiner

2013-10-15T23:59:59.000Z

308

Composite coatings improve engines  

SciTech Connect (OSTI)

About 40% of the power loss in engine systems is attributed to the adverse effects of friction in reciprocating engine components. Over half of this power loss is caused by friction between pistons, piston rings, and cylinder bores. In addition, engine parts may be attacked by corrosive gasoline substitutes such as liquid propane gas and alcohol/gasoline mixtures. To solve both friction and corrosion problems, Nihon Parkerizing Co. has improved the nickel-phosphorus based ceramic composite (NCC) plating technology that was developed for cylinder bores and pistons by Suzuki Motor Co. in the mid 1970s. Iron and nickel-based composite plating technologies have been investigated since the early 1970s, and a few have been used on small two-stroke motorcycle, outboard marine, snowmobile, and some luxury passenger car engine components. Both nickel- and iron-base plating processes are used on cylinders and pistons because they offer excellent wear and corrosion resistance. Nickel-base films have higher corrosion resistance than those based on iron, and are capable of withstanding the corrosive conditions characteristic of high methanol fuels. Unfortunately, they experience a decrease in hardness as operating temperatures increase. However, NCC coatings with phosphorus additions have high hardness even under severe operating conditions, and hardness increases upon exposure to elevated temperatures. In addition to high hardness and corrosion resistance, NCC coatings provide a low friction coefficient, which contributes to the reduction of friction losses between sliding components. When used in low-quality or alcohol fuels, the corrosion resistance of NCC coatings is far higher than that of Fe-P plating. Additionally, the coatings reduce wall and piston temperature, wear of ring groove and skirt, and carbon deposit formation, and they improve output power and torque. These advantages all contribute to the development of light and efficient engines with better fuel mileage.

Funatani, K.; Kurosawa, K. (Nihon Parkerizing Co. Ltd., Nagoya (Japan))

1994-12-01T23:59:59.000Z

309

Abstract LB-187: Dietary energy balance modulation of Kras- and Ink4a/Arf+/-driven pancreatic cancer: the role of insulin-like growth factor-1.  

Science Journals Connector (OSTI)

...Association for Cancer Research. 1 October 2014 meeting-abstract Tumor Biology...mitochondrial energy production and...The improved energy status is linked...mitochondrial energy production and...tumor-initiating cells. [abstract]. In: Proceedings...Association for Cancer Research; 2014 Apr 5-9...

Laura M. Lashinger; Lauren M. Harrison; Audrey J. Rasmussen; Craig D. Logsdon; Susan M. Fischer; Mark J. McArthur; and Stephen D. Hursting

2013-04-15T23:59:59.000Z

310

Roadway Improvement Project Cost Allocation  

E-Print Network [OSTI]

Roadway Improvement Project Cost Allocation CTS 21st Annual Transportation Research Conference costs #12;Potential Applications · Roadway Project Feasibility Studies ­ Identified potential roadway infrastructure improvement ­ Documentation of estimated project costs ­ Determine property assessments

Minnesota, University of

311

Lake Improvement District Law and County Lake Improvement Program  

Broader source: Energy.gov (indexed) [DOE]

Lake Improvement District Law and County Lake Improvement Program Lake Improvement District Law and County Lake Improvement Program (Minnesota) Lake Improvement District Law and County Lake Improvement Program (Minnesota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Minnesota Program Type Siting and Permitting Lake Improvement Districts may be established by county boards in order to

312

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This report describes work performed during the third and final year of the project, ''Conformance Improvement Using Gels.'' Corefloods revealed throughput dependencies of permeability reduction by polymers and gels that were much more prolonged during oil flow than water flow. This behavior was explained using simple mobility ratio arguments. A model was developed that quantitatively fits the results and predicts ''clean up'' times for oil productivity when production wells are returned to service after application of a polymer or gel treatment. X-ray computed microtomography studies of gels in strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene suggested that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than gel-ripping or gel-displacement mechanisms. In contrast, analysis of data from the University of Kansas suggests that the gel-ripping or displacement mechanisms are more important in more permeable, strongly water-wet sandpacks. These findings help to explain why aqueous gels can reduce permeability to water more than to oil under different conditions. Since cement is the most commonly used material for water shutoff, we considered when gels are preferred over cements. Our analysis and experimental results indicated that cement cannot be expected to completely fill (top to bottom) a vertical fracture of any width, except near the wellbore. For vertical fractures with apertures less than 4 mm, the cement slurry will simply not penetrate very far into the fracture. For vertical fractures with apertures greater than 4 mm, the slurry may penetrate a substantial distance into the bottom part of the fracture. However, except near the wellbore, the upper part of the fracture will remain open due to gravity segregation. We compared various approaches to plugging fractures using gels, including (1) varying polymer content, (2) varying placement (extrusion) rate, (3) using partially formed gels, (4) using combinations of high and low molecular weight (Mw) polymers, (5) using secondary crosslinking reactions, (6) injecting un-hydrated polymer particles, and (7) incorporating particulates. All of these methods showed promise in some aspects, but required performance improvements in other aspects. All materials investigated to date showed significant performance variations with fracture width. High pressure gradients and limited distance of penetration are common problems in tight fractures. Gravity segregation and low resistance to breaching are common problems in wide fractures. These will be key issues to address in future work. Although gels can exhibit disproportionate permeability reduction in fractures, the levels of permeability reduction for oil flow are too high to allow practical exploitation in most circumstances. In contrast, disproportionate permeability reduction provided by gels that form in porous rock (adjacent to the fractures) has considerable potential in fractured systems.

Randall S. Seright

2004-09-30T23:59:59.000Z

313

Refines Efficiency Improvement  

SciTech Connect (OSTI)

Refinery processes that convert heavy oils to lighter distillate fuels require heating for distillation, hydrogen addition or carbon rejection (coking). Efficiency is limited by the formation of insoluble carbon-rich coke deposits. Heat exchangers and other refinery units must be shut down for mechanical coke removal, resulting in a significant loss of output and revenue. When a residuum is heated above the temperature at which pyrolysis occurs (340 C, 650 F), there is typically an induction period before coke formation begins (Magaril and Aksenova 1968, Wiehe 1993). To avoid fouling, refiners often stop heating a residuum before coke formation begins, using arbitrary criteria. In many cases, this heating is stopped sooner than need be, resulting in less than maximum product yield. Western Research Institute (WRI) has developed innovative Coking Index concepts (patent pending) which can be used for process control by refiners to heat residua to the threshold, but not beyond the point at which coke formation begins when petroleum residua materials are heated at pyrolysis temperatures (Schabron et al. 2001). The development of this universal predictor solves a long standing problem in petroleum refining. These Coking Indexes have great potential value in improving the efficiency of distillation processes. The Coking Indexes were found to apply to residua in a universal manner, and the theoretical basis for the indexes has been established (Schabron et al. 2001a, 2001b, 2001c). For the first time, a few simple measurements indicates how close undesired coke formation is on the coke formation induction time line. The Coking Indexes can lead to new process controls that can improve refinery distillation efficiency by several percentage points. Petroleum residua consist of an ordered continuum of solvated polar materials usually referred to as asphaltenes dispersed in a lower polarity solvent phase held together by intermediate polarity materials usually referred to as resins. The Coking Indexes focus on the amount of these intermediate polarity species since coke formation begins when these are depleted. Currently the Coking Indexes are determined by either titration or solubility measurements which must be performed in a laboratory. In the current work, various spectral, microscopic, and thermal techniques possibly leading to on-line analysis were explored for measuring the Coking Indexes.

WRI

2002-05-15T23:59:59.000Z

314

Temperature differential detection device  

DOE Patents [OSTI]

A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions.

Girling, Peter M. (Allentown, PA)

1986-01-01T23:59:59.000Z

315

Detecting bioterrorism: Is chemistry enough?  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Detecting bioterrorism: Is chemistry enough? Detecting bioterrorism: Is chemistry enough? In an online webinar, Kristin Omberg will offer discussion on the possibilities and...

316

Skin cancer is the most com-mon form of cancer in the United  

E-Print Network [OSTI]

Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

317

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer  

E-Print Network [OSTI]

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

Salzman, Daniel

318

Cancer Immunol Immunother . Author manuscript Anti-HER2 vaccines: new prospects for breast cancer therapy  

E-Print Network [OSTI]

Cancer Immunol Immunother . Author manuscript Page /1 18 Anti-HER2 vaccines: new prospects for breast cancer therapy Maha Zohra Ladjemi 1 , William Jacot 2 , Thierry Chard sè 1 , Andr P legriné è 1 cancer accounts for more than 400.000 new cancer cases and more than 130.000 cancer deaths in Europe

Paris-Sud XI, Université de

319

Pancreatic Cancer Center: Providing the Research Tools Necessary to Advance Pancreatic Cancer Patient Care  

E-Print Network [OSTI]

Pancreatic Cancer Center: Providing the Research Tools Necessary to Advance Pancreatic Cancer the fourth leading cause of cancer deaths, and PDAC patients have a dismal 5-year survival rate of 6 number of NCI-designated cancer centers have a specialized pancreatic cancer program. The creation

Zhou, Yaoqi

320

Recent Advances from the National Cancer Institute Alliance for Nanotechnology in Cancer  

Science Journals Connector (OSTI)

Recent Advances from the National Cancer Institute Alliance for Nanotechnology in Cancer ... The National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer sponsors research in cancer prevention, diagnosis, and therapy and promotes translation of basic science discoveries into clinical practice. ... The Fourth Annual NCI Alliance Principal Investigator Meeting was held in Manhattan Beach, California October 20?22, 2009. ...

Dorothy Farrell; Joe Alper; Krzystof Ptak; Nicholas J. Panaro; Piotr Grodzinski; Anna D. Barker

2010-02-23T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

CANCER RISKS AM I AT RISK?  

E-Print Network [OSTI]

CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

Hardy, Christopher R.

322

BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY  

E-Print Network [OSTI]

BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

Spence, Harlan Ernest

323

Making a difference... A National Cancer  

E-Print Network [OSTI]

Making a difference... A National Cancer Research Institute (NCRI) Accredited Trials Unit Contacts Cancer Research UK Clinical Trials Unit School of Cancer Sciences University of Birmingham Edgbaston. Funding The CRCTU receives core funding from Cancer Research UK and has successfully obtained project

Birmingham, University of

324

Contact Details Journeying Beyond Breast Cancer  

E-Print Network [OSTI]

Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

Espinosa, Horacio D.

325

ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION  

E-Print Network [OSTI]

, (-)-epigallocatechin-3-gallate (EGCG) from Green tea, Irresa and resveratrol have been shown to exhibit cancer

326

Tevatron improvement program  

SciTech Connect (OSTI)

A modest Tevatron improvement program is suggested which would provide a storage ring for dedicated use as a p anti p collider at 2 TeV (cm) and as an ep collider at 0.2 TeV (cm). It could also serve as a useful test facility for some of the new developments necessary for an economical SSC. Because use could be made of utilities and facilities that are already installed as part of the tevatron, the cost of the p anti p option might be about 100 million dollars (not including the interaction halls or detectors). The additional cost of a 10 x 1000 GeV' ep option might be about 70 million dollars. The experimental facilities at B and D of the Tevatron might be extended for use with the new collider. As the technology of superconducting magnets develops, the cm energy of the p anti p and the ep colliders might be doubled. The intention is either to double the capability of TeV I and TeV II, or to extend the capability by addition of an ep facility. Alternatively, by adding another proton ring, a high luminosity pp facility might also result.

Wilson, R.R.

1983-07-01T23:59:59.000Z

327

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)  

ScienceCinema (OSTI)

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

2011-10-04T23:59:59.000Z

328

Solar system fault detection  

DOE Patents [OSTI]

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, Robert B. (Wheatridge, CO); Pruett, Jr., James C. (Lakewood, CO)

1986-01-01T23:59:59.000Z

329

Composition for detecting uranyl  

DOE Patents [OSTI]

The present invention relates to an indicator composition for use in spectrophotometric detection of a substance in a solution, and a method for making the composition. Useful indicators are sensitive to the particular substance being measured, but are unaffected by the fluid and other chemical species that may be present in the fluid. Optical indicators are used to measure the uranium concentration of process solutions in facilities for extracting uranium from ores, production of nuclear fuels, and reprocessing of irradiated fuels. The composition comprises an organohalide covalently bonded to an indicator for the substance, in such a manner that the product is itself an indicator that provides increased spectral resolution for detecting the substance. The indicator is preferably arsenazo III and the organohalide is preferably cyanuric chloride. These form a composition that is ideally suited for detecting uranyl.

Baylor, L.C.; Stephens, S.M.

1994-01-01T23:59:59.000Z

330

Solar system fault detection  

DOE Patents [OSTI]

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, R.B.; Pruett, J.C. Jr.

1984-05-14T23:59:59.000Z

331

Chapter 1 - Cancer Theranostics: An Introduction  

Science Journals Connector (OSTI)

Cancer theranostics combines cancer diagnosis and cancer therapy, aiming for early diagnosis, accurate molecular imaging, and precise treatment at the right timing and proper dose, followed by real-time monitoring of treatment efficacy. This chapter provides an overview of the state-of-the-art of cancer theranostics from the selection of genomic, proteomic, and metabolomic biomarkers, applying molecular imaging techniques for in vivo measurement of cancer hallmarks, image-guided cancer interventions, citing examples of theranostic platforms triggered by light, magnetism, and sound to the design of nanoparticle platforms for codelivery of imaging labels and therapeutic drugs. The challenges of clinical translation of cancer theranostic approaches are also discussed.

Xiaoyuan Chen; Stephen T.C. Wong

2014-01-01T23:59:59.000Z

332

Abstract ADV23: Bridging the gap: An advocate's breast cancer journey.  

Science Journals Connector (OSTI)

...Screening and Early Detection - Poster Presentations AACR International...of recruitment for prostate education and screening among underserved...to deliver prostate cancer education and awareness in an underserved...included age (p=0.02), education (p=0.002), having a...

Desiree Walker

2013-08-14T23:59:59.000Z

333

Method of detecting genetic translocations identified with chromosomal abnormalities  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Tkachuk, Douglas (Livermore, CA)

2001-01-01T23:59:59.000Z

334

Detection of neutrinos  

DOE Patents [OSTI]

A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

Fischbach, Ephraim; Jenkins, Jere

2014-02-04T23:59:59.000Z

335

Detection of solar events  

DOE Patents [OSTI]

A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

Fischbach, Ephraim; Jenkins, Jere

2013-08-27T23:59:59.000Z

336

3D-FFT for Signature Detection in LWIR Images  

SciTech Connect (OSTI)

Improvements in analysis detection exploitation are possible by applying whitened matched filtering within the Fourier domain to hyperspectral data cubes. We describe an implementation of a Three Dimensional Fast Fourier Transform Whitened Matched Filter (3DFFTMF) approach and, using several example sets of Long Wave Infra Red (LWIR) data cubes, compare the results with those from standard Whitened Matched Filter (WMF) techniques. Since the variability in shape of gaseous plumes precludes the use of spatial conformation in the matched filtering, the 3DFFTMF results were similar to those of two other WMF methods. Including a spatial low-pass filter within the Fourier space can improve signal to noise ratios and therefore improve detection limit by facilitating the mitigation of high frequency clutter. The improvement only occurs if the low-pass filter diameter is smaller than the plume diameter.

Medvick, Patricia A.; Lind, Michael A.; Mackey, Patrick S.; Nuffer, Lisa L.; Foote, Harlan P.

2007-11-20T23:59:59.000Z

337

USHER: Improving Data Quality with Dynamic Forms  

E-Print Network [OSTI]

Abstract — Data quality is a critical problem in modern databases. Data entry forms present the first and arguably best opportunity for detecting and mitigating errors, but there has been little research into automatic methods for improving data quality at entry time. In this paper, we propose USHER, an endto-end system for form design, entry, and data quality assurance. Using previous form submissions, USHER learns a probabilistic model over the questions of the form. USHER then applies this model at every step of the data entry process to improve data quality. Before entry, it induces a form layout that captures the most important data values of a form instance as quickly as possible. During entry, it dynamically adapts the form to the values being entered, and enables real-time feedback to guide the data enterer toward their intended values. After entry, it re-asks questions that it deems likely to have been entered incorrectly. We evaluate all three components of USHER using two real-world data sets. Our results demonstrate that each component has the potential to improve data quality considerably, at a reduced cost when compared to current practice. I.

Kuang Chen; Harr Chen; Neil Conway; Joseph M. Hellerstein; Tapan S. Parikh

338

Inequalities in reported cancer patient experience by sociodemographic characteristic and cancer site: Evidence from respondents to the English Cancer Patient Experience Survey  

E-Print Network [OSTI]

practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England. Lancet Oncol, 13, 353-65. Macmillan Cancer Support 2012-2013. Cancer Patient Experience Survey: Insight Report...

Saunders, Catherine L.; Abel, Gary A.; Lyratzopoulos, Georgios

2014-01-01T23:59:59.000Z

339

Singlet Oxygen Singlet oxygen generation and detection are growing fields with applications in such areas as  

E-Print Network [OSTI]

Singlet Oxygen Singlet oxygen generation and detection are growing fields with applications in such areas as cancer treatment, photosensitized oxidations, and biomolecular degradation. Ground state oxygen state of an oxygen molecule is a singlet state, which can readily react with other singlet molecules

Wells, Mathew G. - Department of Physical and Environmental Sciences, University of Toronto

340

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This report describes work performed during the second year of the project, ''Conformance Improvement Using Gels.'' The project has two objectives. The first objective is to identify gel compositions and conditions that substantially reduce flow through fractures that allow direct channeling between wells, while leaving secondary fractures open so that high fluid injection and production rates can be maintained. The second objective is to optimize treatments in fractured production wells, where the gel must reduce permeability to water much more than that to oil. Pore-level images from X-ray computed microtomography were re-examined for Berea sandstone and porous polyethylene. This analysis suggests that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than a gel-ripping mechanism. This finding helps to explain why aqueous gels can reduce permeability to water more than to oil. We analyzed a Cr(III)-acetate-HPAM gel treatment in a production well in the Arbuckle formation. The availability of accurate pressure data before, during, and after the treatment was critical for the analysis. After the gel treatment, water productivity was fairly constant at about 20% of the pre-treatment value. However, oil productivity was stimulated by a factor of 18 immediately after the treatment. During the six months after the treatment, oil productivity gradually decreased to approach the pre-treatment value. To explain this behavior, we proposed that the fracture area open to oil flow was increased substantially by the gel treatment, followed by a gradual closing of the fractures during subsequent production. For a conventional Cr(III)-acetate-HPAM gel, the delay between gelant preparation and injection into a fracture impacts the placement, leakoff, and permeability reduction behavior. Formulations placed as partially formed gels showed relatively low pressure gradients during placement, and yet substantially reduced the flow capacity of fractures (with widths from 1 to 4 mm) during brine and oil flow after placement. Regardless of gel age before placement, very little gel washed out from the fractures during brine or oil flow. However, increased brine or oil flow rate and cyclic injection of oil and water significantly decreased the level of permeability reduction. A particular need exists for gels that can plug large apertures (e.g., wide fractures and vugs). Improved mechanical strength and stability were demonstrated (in 1- to 4-mm-wide fractures) for a gel that contained a combination of high- and low-molecular weight polymers. This gel reduced the flow capacity of 2- and 4-mm-wide fractures by 260,000. In a 1-mm-wide fracture, it withstood 26 psi/ft without allowing any brine flow through the fracture. Cr(III)-acetate-HPAM gels exhibited disproportionate permeability reduction in fractures. The effect was most pronounced when the gel was placed as gelant or partially formed gels. The effect occurred to a modest extent with concentrated gels and with gels that were ''fully formed'' when placed. The effect was not evident in tubes. We explored swelling polymers for plugging fractures. Polymer suspensions were quickly prepared and injected. In concept, the partially dissolved polymer would lodge and swell to plug the fracture. For three types of swelling polymers, behavior was promising. However, additional development is needed before their performance will be superior to that of conventional gels.

Randall S. Seright

2003-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Volumetric modulated arc radiotherapy for esophageal cancer  

SciTech Connect (OSTI)

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

2012-04-01T23:59:59.000Z

342

Green Tea and Gastric Cancer  

Science Journals Connector (OSTI)

...People in Japan have welcomed these findings, and green tea is widely viewed as a healthful beverage. Indeed, it no longer needs to be prepared in a teapot at home. Canned or bottled green tea is now widely available in vending machines and convenience stores throughout Japan, along with soft drinks and... Gastric cancer was once the leading cause of cancer-related death in most countries, including the United States. Since 1930 the incidence of gastric cancer has steadily decreased throughout the world, with dramatic decreases in the West. In 1994, gastric ...

Sano T.; Sasako M.

2001-03-01T23:59:59.000Z

343

The Cancer Genome Atlas Pan-Cancer analysis project  

E-Print Network [OSTI]

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

Lander, Eric S.

344

Differential expression of intronless carcinoma-associated antigen GA733-1 in two distinct classes of human breast cancer cell lines  

SciTech Connect (OSTI)

Using differential hybridization, we have isolated a 0.8-kb GA733-1 cDNA clone which was selectively expressed in the MCF-7 and Au565 breast cancer cell lines but not in MB231 cells. Subsequent studies with 10 additional breast cancer cell lines have allowed us to identify two classes of breast cancer cell lines that display distinct expression of the GA733-1 antigen as well as other cellular parameters. The six GA733-1{sup +} cell lines (MCF-7, ZR75-1, MB468, Au565, BJ015, and MB453) exhibit a spherical or cuboidal shape. These cells tend to grow in clusters and display extensive cell-cell connections. In contrast, all GA733-1{sup -} cells (MB435s, MB231, MB436, MB157, BT549, and Hs578T) assume a more elongated, fibroblast-like morphology and grow in a discrete, uniform pattern. These results are consistent with previous findings suggesting the GA733 gene products function as cell-cell adhesion molecules. Generally, the GA733-1{sup -} cells actively produce lipid vesicles, whereas the GA733-1{sup +} cells are virtually inactive in lipid production. In addition, all six GA733-1{sup +} cell lines express keratin 19, which is only weakly expressed or not detectable in the GA733-1{sup -} cells. Comparative analysis of our results with previous studies has shown that GA733-1 expression is inversely related to vimentin expression and that the GA733-1{sup -}/VIM{sup +} cells display a much higher invasive propensity than the GA733-1{sup +}/VIM{sup -} lines in both in vitro and in vivo assays. However, there seems no obvious correlation of GA733-1 expression with that of estrogen receptor (ER) except that no GA733-1{sup -} cell lines express the receptor. The combination of these four parameters (ER, GA733-1, vimentin, and keratin 19), should contribute to the reliability of the histological grading of breast cancer and may provide a basis for improved treatment of breast cancer.

Xie, Bei; Horio, Murao; Collart, F.R. [and others

1995-07-28T23:59:59.000Z

345

Explosives Detection, Testing, Ballistics and Armor Development...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Explosives Detection, Testing, Ballistics, and Armor Development Programs Locations: National Security Test Range, Trace Explosives Detection Facility, Bulk Explosives Detection...

346

School Response to Families with Children with Cancer  

E-Print Network [OSTI]

Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

Nielsen, Shelley Lynn

2010-01-01T23:59:59.000Z

347

Stromal Modulation of Radiation Carcinogenesis in Breast Cancer  

E-Print Network [OSTI]

receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

Nguyen, David Hiendat Hua

2011-01-01T23:59:59.000Z

348

Technology "Relay Race" Against Cancer | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GE Scientists in Technology "Relay Race" Against Cancer GE Scientists in Technology "Relay Race" Against Cancer GE technologies being developed to impact every stage of cancer...

349

Biodynamic Imaging: Rethinking Cancer Care using Light-Scattering Theranostics  

Science Journals Connector (OSTI)

Personalized cancer care holds significant potential for the selection of more effective cancer treatments. We present the first predictive screen for cancer therapy selection that...

Nolte, David D

350

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

E-Print Network [OSTI]

2007;318:1108–1113.   8.  Cancer Genome Atlas Network.  somatic mutation in human cancer genomes.   Nature 2007;446:153–158.   11.  Katoh M.  Cancer genomics and genetics of 

Spellman, Paul T.

2011-01-01T23:59:59.000Z

351

Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.  

E-Print Network [OSTI]

Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

2012-01-01T23:59:59.000Z

352

Elevated Cancer Mortality in the Relatives of Patients with Pancreatic Cancer  

Science Journals Connector (OSTI)

2009 American Association for Cancer Research. November 2009 research-article Research Articles Elevated Cancer Mortality in the Relatives of Patients with Pancreatic Cancer Li Wang 1 Kieran A. Brune 2 Kala Visvanathan 1 3 Daniel Laheru 3 Joseph...

Li Wang; Kieran A. Brune; Kala Visvanathan; Daniel Laheru; Joseph Herman; Christoper Wolfgang; Richard Schulick; John L. Cameron; Michael Goggins; Ralph H. Hruban; Alison P. Klein

2009-11-01T23:59:59.000Z

353

Lung Cancer Assistant: a hybrid clinical decision support application for lung cancer care  

Science Journals Connector (OSTI)

...author and source are credited. Lung Cancer Assistant: a hybrid clinical decision support application for lung cancer care M. Berkan Sesen 1 Michael D...meetings are becoming the model of care for cancer patients worldwide. While MDTs have...

2014-01-01T23:59:59.000Z

354

Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer  

Science Journals Connector (OSTI)

American Association for Cancer Research Article Research Articles Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer Polly A. Newcomb 1 Requests for reprints: Polly...

Polly A. Newcomb; John Baron; Michelle Cotterchio; Steve Gallinger; John Grove; Robert Haile; David Hall; John L. Hopper; Jeremy Jass; Loïc Le Marchand; Paul Limburg; Noralane Lindor; John D. Potter; Allyson S. Templeton; Steve Thibodeau; Daniela Seminara

2007-11-01T23:59:59.000Z

355

CHEK2 1100delC and polygenic susceptibility to breast cancer and colorectal cancer.  

E-Print Network [OSTI]

??abstractApproximately 15-25% of breast cancers are identified in women with a family history of breast cancer. Yet, germline mutations in the currently known breast cancer… (more)

M. Wasielewski (Marijke)

2009-01-01T23:59:59.000Z

356

Abstract A33: Exploring pediatric cancer genomics with the UCSC Cancer Genomics Browser  

Science Journals Connector (OSTI)

...University of California, Santa Cruz, CA. The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) is a set of web-based tools to display, investigate and analyze cancer genomics data and associated clinical data. Experimental quantities...

Melissa Cline; Olena Morozova; Teresa Swatloski; Brian Craft; Mary Goldman; David Haussler; Jingchun Zhu

2014-10-15T23:59:59.000Z

357

Nitrogen dioxide detection  

DOE Patents [OSTI]

Method and apparatus for detecting the presence of gaseous nitrogen dioxide and determining the amount of gas which is present. Though polystyrene is normally an insulator, it becomes electrically conductive in the presence of nitrogen dioxide. Conductance or resistance of a polystyrene sensing element is related to the concentration of nitrogen dioxide at the sensing element.

Sinha, Dipen N. (Los Alamos, NM); Agnew, Stephen F. (Los Alamos, NM); Christensen, William H. (Buena Park, CA)

1993-01-01T23:59:59.000Z

358

Development, Implementation, and Testing of Fault Detection Strategies on the National Wind Technology Center's Controls Advanced Research Turbines  

SciTech Connect (OSTI)

The National Renewable Energy Laboratory's National Wind Technology Center dedicates two 600 kW turbines for advanced control systems research. A fault detection system for both turbines has been developed, analyzed, and improved across years of experiments to protect the turbines as each new controller is tested. Analysis of field data and ongoing fault detection strategy improvements have resulted in a system of sensors, fault definitions, and detection strategies that have thus far been effective at protecting the turbines. In this paper, we document this fault detection system and provide field data illustrating its operation while detecting a range of failures. In some cases, we discuss the refinement process over time as fault detection strategies were improved. The purpose of this article is to share field experience obtained during the development and field testing of the existing fault detection system, and to offer a possible baseline for comparison with more advanced turbine fault detection controllers.

Johnson, K. E.; Fleming, P. A.

2011-06-01T23:59:59.000Z

359

DNA Synthesis and Repair Genes RRM1 and ERCC1 in Lung Cancer  

Science Journals Connector (OSTI)

Lung cancer accounts for more than one fourth of all cancer-related deaths in the United States, despite improvements in diagnosis and management. Only recently have molecular markers become integrated into decisions about the treatment of lung cancer, largely through the discovery of mutations in... This study of early-stage non–small-cell lung cancer showed that high levels of RRM1 in the tumor were associated with prolonged disease-free survival, as compared with low levels of RRM1. High levels of another protein in the tumor, ERCC1, were also associated with a good prognosis. The major benefit of surgery was confined to the 30% of patients in whom high levels of both RRM1 and ERCC1 were present in the tumor.

Zheng Z.; Chen T.; Li X.

2007-02-22T23:59:59.000Z

360

Oral complications of cancer therapies. Oral complications in the pediatric population  

SciTech Connect (OSTI)

A number of acute oral complications may be associated with cancer therapy in children, but the extent and duration of these complications, and the most effective management techniques. have not been well described. The few studies differ in design, making comparisons difficult. Well-controlled, prospective clinical studies are needed to define the most effective strategies for the management of acute oral complications in children. However, it is clear that dental intervention prior to cancer therapy is an important factor in the optimal preparation of the patient. During cancer therapy, intensive supervised oral preventive protocols appear to be of benefit to the child's oral health, overall comfort, and well-being. Furthermore, the prevention of oral infection may significantly reduce the morbidity associated with cancer therapy. Long-term preventive oral care may help prevent dental disease and infection in medically compromised children and contribute to improving the quality of life. 41 references.

Leggott, P.J. (Univ. of California, San Francisco (USA))

1990-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

DIFFERENTIAL SOIL IMPEDANCE OBSTACLE DETECTION  

SciTech Connect (OSTI)

This project develops a new and unique obstacle detection sensor for horizontal directional drilling (HDD) equipment. The development of this new technology will greatly improve the reliability and safety of natural gas HDD construction practices. This sensor utilizes a differential soil impedance measurement technique that will be sensitive to the presence of plastic and ceramic, as well as metallic obstacles. The use of HDD equipment has risen significantly in the gas industry because HDD provides a much more cost-effective and less disruptive method for gas pipe installation than older, trenching methods. However, there have been isolated strikes of underground utilities by HDD equipment, which may have been avoided if methods were available to detect other underground obstacles when using HDD systems. GTI advisors from the gas industry have ranked the value of solving the obstacle detection problem as the most important research and development project for GTI to pursue using Federal Energy Regulatory Commission (FERC) funds available through its industry partner, GRI. GTI proposes to develop a prototype down-hole sensor system that is simple and compact. The sensor utilizes an impedance measurement technique that is sensitive to the presence of metallic or nonmetallic objects in the proximity of the HDD head. The system will use a thin film sensor conformal with the drill head. The impedance of the soil will be measured with a low frequency signal injected through the drill head itself. A pair of bridge type impedance sensors, mounted orthogonal to one another, is capacitively coupled to the soil. Inclusions in the soil will cause changes to the sensor balance distinguishable from homogeneous soil. The sensor will provide range and direction data for obstacles near the HDD head. The goal is to provide a simple, robust system that provides the information required to avoid obstacles. This must be done within the size and ruggedness constraints of the HDD equipment. Imaging obstacles is not within the scope of this work, as it would require a more elaborate sensor than is practical within the HDD head.

Maximillian J. Kieba

2002-08-30T23:59:59.000Z

362

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This technical progress report describes work performed from September 1, 2003, through February 29, 2004, for the project, ''Conformance Improvement Using Gels.'' We examined the properties of several ''partially formed'' gels that were formulated with a combination of high and low molecular weight HPAM polymers. After placement in 4-mm-wide fractures, these gels required about 25 psi/ft for brine to breach the gel (the best performance to date in fractures this wide). After this breach, stabilized residual resistance factors decreased significantly with increased flow rate. Also, residual resistance factors were up to 9 times greater for water than for oil. Nevertheless, permeability reduction factors were substantial for both water and oil flow. Gel with 2.5% chopped fiberglass effectively plugged 4-mm-wide fractures if a 0.5-mm-wide constriction was present. The ability to screen-out at a constriction appears crucial for particulate incorporation to be useful in plugging fractures. In addition to fiberglass, we examined incorporation of polypropylene fibers into gels. Once dispersed in brine or gelant, the polypropylene fibers exhibited the least gravity segregation of any particulate that we have tested to date. In fractures with widths of at least 2 mm, 24-hr-old gels (0.5% high molecular weight HPAM) with 0.5% fiber did not exhibit progressive plugging during placement and showed extrusion pressure gradients similar to those of gels without the fiber. The presence of the fiber roughly doubled the gel's resistance to first breach by brine flow. The breaching pressure gradients were not as large as for gels made with high and low molecular weight polymers (mentioned above). However, their material requirements and costs (i.e., polymer and/or particulate concentrations) were substantially lower than for those gels. A partially formed gel made with 0.5% HPAM did not enter a 0.052-mm-wide fracture when applying a pressure gradient of 65 psi/ft. This result suggests a lower limit of fracture width for entry of formed or partially formed gels (when reasonable pressure gradients are applied). In unfractured porous rock, we investigated the time dependence of oil and water permeabilities during various cycles of oil and water injection after placement of a Cr(III)-acetate-HPAM gel. Permeability to water stabilized rapidly (within 1 pore volume, PV), while permeability to oil stabilized gradually over the course of 100 PV. The behavior was surprisingly insensitive to core material (strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene), core permeability (740 to 10,000 md), and applied pressure gradient (10 to 100 psi/ft).

Randall S. Seright

2004-03-01T23:59:59.000Z

363

Decoy-state quantum key distribution using homodyne detection  

SciTech Connect (OSTI)

In this paper, we propose to use the decoy-state technique to improve the security of the quantum key distribution (QKD) systems based on homodyne detection against the photon number splitting attack. The decoy-state technique is a powerful tool that can significantly boost the secure transmission range of the QKD systems. However, it has not yet been applied to the systems that use homodyne detection. After adapting this theory to the systems based on homodyne detection, we quantify the secure performance and transmission range of the resulting system.

Shams Mousavi, S. H. [Ecole Superieure d'Electricite (Supelec), Photonic and Communication Systems, 2 rue Edouard Belin, 57070 Metz (France); Gallion, P. [TELECOM ParisTech, Ecole Nationale Superieure des Telecommunications, CNRS LTCI UMR 5141, 46 rue Barrault, 75013 Paris (France)

2009-07-15T23:59:59.000Z

364

Dynamic Program Phase Detection in Distributed Shared-Memory Multiprocessors  

SciTech Connect (OSTI)

We present a novel hardware mechanism for dynamic program phase detection in distributed shared-memory (DSM) multiprocessors. We show that successful hardware mechanisms for phase detection in uniprocessors do not necessarily work well in DSM systems, since they lack the ability to incorporate the parallel application's global execution information and memory access behavior based on data distribution. We then propose a hardware extension to a well-known uniprocessor mechanism that significantly improves phase detection in the context of DSM multiprocessors. The resulting mechanism is modest in size and complexity, and is transparent to the parallel application.

Ipek, E; Martinez, J F; de Supinski, B R; McKee, S A; Schulz, M

2006-03-06T23:59:59.000Z

365

Acetate metabolism in cancer cells  

E-Print Network [OSTI]

Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for ...

Hosios, Aaron M

2014-01-01T23:59:59.000Z

366

Whose genes can stomach cancer?  

Science Journals Connector (OSTI)

... a person develops stomach cancer depends partly on their genes, new research suggests. As John Whitfield reports, this discovery could help prevent the disease. El-Omar,E. M. ...

John Whitfield

2000-03-23T23:59:59.000Z

367

AACR Cancer Progress Report 2014  

Science Journals Connector (OSTI)

...Unfortunately, the prognosis is usually not good. The treatment was to remove the tumor...through 2015. Second, realizing the internet would give them the greatest reach...worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: International Agency...

Carlos L. Arteaga; Peter C. Adamson; Jeffrey A. Engelman; Margaret Foti; Richard B. Gaynor; Susan G. Hilsenbeck; Paul J. Limburg; Scott W. Lowe; Elaine R. Mardis; Scott Ramsey; Timothy R. Rebbeck; Andrea L. Richardson; Eric H. Rubin; and George J. Weiner

2014-10-01T23:59:59.000Z

368

Strategic Workshops on Cancer Nanotechnology  

Science Journals Connector (OSTI)

...Reports Strategic Workshops on Cancer Nanotechnology Larry A. Nagahara 1 Jerry S.H...Maryland; 2 Independent Consultant, 3 Nanotechnology Characterization Laboratory, Advanced...Consulting, Louisville, Colorado Nanotechnology offers the potential for new approaches...

Larry A. Nagahara; Jerry S.H. Lee; Linda K. Molnar; Nicholas J. Panaro; Dorothy Farrell; Krzysztof Ptak; Joseph Alper; Piotr Grodzinski

2010-06-01T23:59:59.000Z

369

AACR Cancer Progress Report 2014  

Science Journals Connector (OSTI)

...suggested I contact Dr. Alice Shaw at Massachusetts General Hospital, who was conducting...RICHARD MURPHY AGE 49 MARSHFIELD, MASSACHUSETTS After I was diagnosed, I just hoped...Sasieni P. 13. Cancers attributable to solar (ultraviolet) radiation exposure in...

Carlos L. Arteaga; Peter C. Adamson; Jeffrey A. Engelman; Margaret Foti; Richard B. Gaynor; Susan G. Hilsenbeck; Paul J. Limburg; Scott W. Lowe; Elaine R. Mardis; Scott Ramsey; Timothy R. Rebbeck; Andrea L. Richardson; Eric H. Rubin; and George J. Weiner

2014-10-01T23:59:59.000Z

370

Nanolubricants to Improve Chiller Performance  

Broader source: Energy.gov (indexed) [DOE]

Nanolubricants to Improve Chiller Nanolubricants to Improve Chiller Performance Mark Kedzierski NIST MAK@NIST.GOV 301 975 5282 April 3, 2013 2 | Building Technologies Office eere.energy.gov Purpose & Objectives Problem Statement: Enabling technology for improving the efficiency of chillers that cool large buildings with nanolubricants. (Nanolubricants are not currently used in chillers.) Develop fundamental understanding of how nanolubricants enhance refrigerant/nanolubricant. What nanoparticle size,

371

Fusion genes in breast cancer  

E-Print Network [OSTI]

Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

Batty, Elizabeth

2012-02-07T23:59:59.000Z

372

New Light on Improving Engine Efficiencies | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Crystal Structure of a Meta-stable Intermediate Particle in Virus The Crystal Structure of a Meta-stable Intermediate Particle in Virus Assembly Increasing Magnetic Response of Ferromagnetic Semiconductors under High Pressure Better Switching Through Chemistry in Thin Ferroelectrics First Molecular-Level Enzyme Images Could Improve Breast-Cancer Therapy Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed New Light on Improving Engine Efficiencies MARCH 3, 2009 Bookmark and Share The DOE, as part of its Clean Coal & Natural Gas Power Systems initiative, has a "Turbines of Tomorrow" program with the Program Performance Goal to: "By 2010, develop turbine technology that is capable of efficiently

373

Improve Your Boiler's Combustion Efficiency  

SciTech Connect (OSTI)

This revised ITP tip sheet on boiler combustion efficiency provides how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

Not Available

2006-01-01T23:59:59.000Z

374

Improving Design with Agents, Improving Agents by Design  

E-Print Network [OSTI]

DCB 1 WPI Improving Design with Agents, or, Improving Agents by Design David C. Brown AI in Design ASSUMPTION Ã? Assume that the design environment is built using agents. i.e., situated, autonomous, flexible Ã?'s future design and synthesis environment will be built as a real multi-agent system. In what follows, we

Brown, David C.

375

Solar neutrino detection  

SciTech Connect (OSTI)

More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

Miramonti, Lino [Physics department of Milano University and INFN (Italy)

2009-04-30T23:59:59.000Z

376

Idaho Explosives Detection System  

SciTech Connect (OSTI)

The Idaho Explosives Detection System was developed at the Idaho National Laboratory (INL) to respond to threats imposed by delivery trucks potentially carrying explosives into military bases. A full-scale prototype system has been built and is currently undergoing testing. The system consists of two racks, one on each side of a subject vehicle. Each rack includes a neutron generator and an array of NaI detectors. The two neutron generators are pulsed and synchronized. A laptop computer controls the entire system. The control software is easily operable by minimally trained staff. The system was developed to detect explosives in a medium size truck within a 5-min measurement time. System performance was successfully demonstrated with explosives at the INL in June 2004 and at Andrews Air Force Base in July 2004.

Edward L. Reber; Larry G. Blackwood; Andrew J. Edwards; J. Keith Jewell; Kenneth W. Rohde; Edward H. Seabury; Jeffery B. Klinger

2005-12-01T23:59:59.000Z

377

Solar neutrino detection  

E-Print Network [OSTI]

More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

Lino Miramonti

2009-01-22T23:59:59.000Z

378

Cell Phone Detection Techniques  

SciTech Connect (OSTI)

A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phone’s electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

2007-10-01T23:59:59.000Z

379

Protein detection system  

DOE Patents [OSTI]

The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.

Fruetel, Julie A. (Livermore, CA); Fiechtner, Gregory J. (Bethesda, MD); Kliner, Dahv A. V. (San Ramon, CA); McIlroy, Andrew (Livermore, CA)

2009-05-05T23:59:59.000Z

380

Nanomedicine and its applications to the treatment of prostate cancer  

Science Journals Connector (OSTI)

Summary In recent years, nanotechnology has been the focus of considerable attention in medicine due to the facility with which nanostructures interact with the body at the molecular scale. New therapies in cancer research using nanomedicine are being developed in order to improve the specificity and efficacy of drug delivery, thus reaching maximal effectiveness with minimal side effects. This literature review presents cases of prostate cancer in antiquity as well as the first modern reports before discussing how nanotechnology can contribute to the management of this disease. Three major nanoparticle-based platforms are described: liposomal, polymeric and metallic. Published results, including therapies in current clinical trials, are discussed. In addition, several formulations of microparticles containing LH-RH analogues approved by the authorities are listed in this document. A critical analysis of the health and environmental impact is made to highlight the need for precise control of the utilization of nanomaterials.

R. Ouvinha de Oliveira; L.C. de Santa Maria; G. Barratt

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Aspects of leak detection  

SciTech Connect (OSTI)

A requirement of a Leak before Break safety case is that the leakage from the through wall crack be detected prior to any growth leading to unacceptable failure. This paper sets out to review some recent developments in this field. It does not set out to be a comprehensive guide to all of the methods available. The discussion concentrates on acoustic emission and how the techniques can be qualified and deployed on operational plant.

Chivers, T.C. [Berkeley Technology Centre, Glos (United Kingdom)

1997-04-01T23:59:59.000Z

382

Detection of structural degradation  

SciTech Connect (OSTI)

A time domain method developed for determining dynamic system characteristics is applied to structural monitoring and/or flaw detection. The potential usefulness for monitoring is evaluated based on several criteria, which include sensitivity to structural changes, location of flaws, and dependence upon excitation signals. The strengths and weaknesses of the methods are discussed. Also, structural monitoring using a signal's singular values is presented and evaluated. 2 refs., 4 figs., 2 tabs.

Endebrock, E.G.

1991-01-01T23:59:59.000Z

383

Method for detecting biomolecules  

DOE Patents [OSTI]

A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode

Huo, Qisheng (Albuquerque, NM); Liu, Jun (Albuquerque, NM)

2008-08-12T23:59:59.000Z

384

Nucleic acid detection methods  

DOE Patents [OSTI]

The invention relates to methods for rapidly determining the sequence and/or length a target sequence. The target sequence may be a series of known or unknown repeat sequences which are hybridized to an array of probes. The hybridized array is digested with a single-strand nuclease and free 3{prime}-hydroxyl groups extended with a nucleic acid polymerase. Nuclease cleaved heteroduplexes can be easily distinguish from nuclease uncleaved heteroduplexes by differential labeling. Probes and target can be differentially labeled with detectable labels. Matched target can be detected by cleaving resulting loops from the hybridized target and creating free 3-hydroxyl groups. These groups are recognized and extended by polymerases added into the reaction system which also adds or releases one label into solution. Analysis of the resulting products using either solid phase or solution. These methods can be used to detect characteristic nucleic acid sequences, to determine target sequence and to screen for genetic defects and disorders. Assays can be conducted on solid surfaces allowing for multiple reactions to be conducted in parallel and, if desired, automated. 18 figs.

Smith, C.L.; Yaar, R.; Szafranski, P.; Cantor, C.R.

1998-05-19T23:59:59.000Z

385

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network [OSTI]

and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

386

An analytics approach to designing clinical trials for cancer  

E-Print Network [OSTI]

Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer ...

Relyea, Stephen L. (Stephen Lawrence)

2013-01-01T23:59:59.000Z

387

An international evaluation of the cancer preventive potential of carotenoids.  

Science Journals Connector (OSTI)

...second volume of the IARC Handbooks of Cancer Prevention...beta-carotene not only does not prevent lung cancer...second volume of the IARC Handbooks of Cancer Prevention...beta-carotene not only does not prevent lung cancer...

H Vainio and M Rautalahti

1998-08-01T23:59:59.000Z

388

Remote detection of fissile material : Cherenkov counters for gamma detection  

E-Print Network [OSTI]

The need for large-size detectors for long-range active interrogation (Al) detection has generated interest in water-based detector technologies. AI is done using external radiation sources to induce fission and to detect, ...

Erickson, Anna S

2011-01-01T23:59:59.000Z

389

Revolution in nuclear detection affairs  

SciTech Connect (OSTI)

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

Stern, Warren M. [Nonproliferation and National Security Department, Brookhaven National Laboratory, Upton, New York (United States)

2014-05-09T23:59:59.000Z

390

Has the National Health Insurance improved the inequality in the use of tertiary-care hospitals in Korea?  

Science Journals Connector (OSTI)

AbstractBackground To improve financial protection against catastrophic illness, the Korean government expanded the benefit coverage of the National Health Insurance (NHI) for cancer patients in 2005. This paper examined whether the policy has reduced income-inequality in the use of tertiary care hospitals. Methods We evaluated the effect of the policy on income-inequalities in outpatient visits and inpatient admissions to tertiary care hospitals, based on triple difference estimators. Using nationwide claims data of the NHI from 2002 to 2010, we compared cancer patients as a treatment group with liver disease and cardio-cerebrovascular disease as control groups and the lower-income with the highest-income group. Results Before the introduction of the policy, lower-income cancer patients utilized less inpatient and outpatient services in tertiary care hospitals than high-income patients did. After the benefit coverage was expanded, while the incidence and total number of inpatient admissions to tertiary care hospitals increased among cancer patients compared with liver diseases, lower-income cancer patients experienced a greater increase than those of higher-income did compared with both diseases. The use of outpatient services increased more in cancer patients than those of both diseases; however, the gap between the highest- and the lowest-income rarely decreased, except the incidence of visits when compared to liver disease. Conclusion Our findings indicated that the expanded NHI benefits coverage partially improved income-related inequalities in inpatient admissions to tertiary-care hospital, but not in outpatient visits.

Sujin Kim; Soonman Kwon

2014-01-01T23:59:59.000Z

391

Noninvasive identification of bladder cancer with sub-surface backscattered light  

SciTech Connect (OSTI)

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorption bands in the tissue also add useful complexity to the spectral data collected. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering as well as absorption. The data acquisition and storage/display time with the OBS instrument is {approximately}1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g., as in skin cancer or cervical cancer). We report here specifically on its potential application in the detection of bladder cancer.

Bigio, I.J.; Mourant, J.R.; Boyer, J.; Johnson, T.; Shimada, T. [Los Alamos National Lab., NM (United States); Conn, R.L. [Lovelace Medical Center, Albuquerque, NM (United States). Dept. of Urology

1994-02-01T23:59:59.000Z

392

Abstract 1840: What are the implications for cancer research of placing cancer on the global health agenda  

Science Journals Connector (OSTI)

...Abstract 1840: What are the implications for cancer research of placing cancer on the global health agenda Norie Kawahara 1...placing cancer on the global health agenda. Recently the global health implications of cancer have been gaining...

Norie Kawahara; Hideyuki Akaza; Jae Kyung Roh; Akira Nakagawara; Tohru Masui; Shigeo Horie; Haruhiko Sugimura; and Hajime Inoue

2011-07-12T23:59:59.000Z

393

Using Friends as Sensors to Detect Global-Scale Contagious Outbreaks  

E-Print Network [OSTI]

Recent research has focused on the monitoring of global–scale online data for improved detection of epidemics, mood patterns, movements in the stock market political revolutions, box-office revenues, consumer behaviour and ...

Garcia-Herranz, Manuel

394

A Markov Blanket-Based Method for Detecting Causal SNPs in GWAS  

E-Print Network [OSTI]

Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis and treatment of these diseases. With the development of genome-wide association studies (GWAS), designing ...

Han, Bing; Park, Meeyoung; Chen, Xue-wen

2010-04-29T23:59:59.000Z

395

Improved Radiation Dosimetry/Risk Estimates to Facilitate Environmental Management of Plutonium-Contaminated Sites  

SciTech Connect (OSTI)

This report summarizes 4 years of research achievements in this Office of Science (BER), U.S. Department of Energy (DOE) project. The research described was conducted by scientists and supporting staff at Lovelace Respiratory Research Institute (LRRI)/Lovelace Biomedical and Environmental Research Institute (LBERI) and the Southern Urals Biophysics Institute (SUBI). All project objectives and goals were achieved. A major focus was on obtaining improved cancer risk estimates for exposure via inhalation to plutonium (Pu) isotopes in the workplace (DOE radiation workers) and environment (public exposures to Pu-contaminated soil). A major finding was that low doses and dose rates of gamma rays can significantly suppress cancer induction by alpha radiation from inhaled Pu isotopes. The suppression relates to stimulation of the body's natural defenses, including immunity against cancer cells and selective apoptosis which removes precancerous and other aberrant cells.

Scott, Bobby R.; Tokarskaya, Zoya B.; Zhuntova, Galina V.; Osovets, Sergey V.; Syrchikov, Victor A., Belyaeva, Zinaida D.

2007-12-14T23:59:59.000Z

396

Clinical Cancer Care Full screening services and diagnostics  

E-Print Network [OSTI]

Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

Myers, Lawrence C.

397

Chapter 26 - Application of Theranostics to Measure and Treat Cell Heterogeneity in Cancer  

Science Journals Connector (OSTI)

Individualized therapy is a noble anticipation in oncology. It would permit not only to adapt a treatment to an individual’s physiology and characteristics, but also to pinpoint therapeutic features for each neoplasia. The high degree of cell heterogeneity in cancer, with mixtures of cells of different origins and cell populations that evolve toward multiple genomic and epigenomic profiles, makes the precise targeting and treatment of each abnormal cell a priority. The phenotypic nature of heterogeneity in cancer is largely determined by changes in gene transcription requiring the identification of an increasing number of intracellular and even intranuclear markers. Such a requirement brings new challenges for state-of-the-art technology focusing on single-cell analysis and begs for the development of nanotools that can provide the multiplex approach necessary to target cancer locations and reach, detect, and appropriately treat subgroups of cells. In this chapter we introduce the reader to the origins of cell heterogeneity in cancer and discuss how this emerging knowledge has shed light on the difficulties encountered in the management of neoplasias over the past few decades. Our analysis illustrates how nanotheranostics might help effectively address the issue of cell heterogeneity to halt cancer progression, overcome resistance to treatment, and possibly decrease cancer risks among individuals.

Sophie A. Lelièvre; Kurt B. Hodges; Pierre-Alexandre Vidi

2014-01-01T23:59:59.000Z

398

New Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier  

Open Energy Info (EERE)

Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Detection And Rejection Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: New Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Detection And Rejection Details Activities (1) Areas (1) Regions (0) Abstract: We present new improved equations for three still widely used Na/K, Na/Li and SiO2 geothermometers (obtained by statistical treatment of the data and application of outlier detection and rejection as well as theory of error propagation) and compare them with those by Fournier and others. New equations are also developed for estimating errors associated with the use of these new geothermometric equations and comparing them with the performance of the original equations. The errors in the use of the new

399

Collision detection and proximity queries  

Science Journals Connector (OSTI)

This course will primarily cover widely accepted and proved methodologies in collision detection. In addition more advanced or recent topics such as continuous collision detection, ADFs, and using graphics hardware will be introduced. When appropriate ...

Sunil Hadap; Dave Eberle; Pascal Volino; Ming C. Lin; Stephane Redon; Christer Ericson

2004-08-01T23:59:59.000Z

400

Targeted alpha therapy for cancer  

Science Journals Connector (OSTI)

Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT is tested by in vitro and in vivo studies in melanoma, leukaemia, colorectal, breast and prostate cancers, and by a phase 1 trial of intralesional TAT for melanoma. The alpha-emitting radioisotope used is Bi-213, which is eluted from the Ac-225 generator and chelated to a cancer specific monoclonal antibody (mab) or protein (e.g. plasminogen activator inhibitor-2 PAI2) to form the alpha-conjugate (AC). Stable alpha-ACs have been produced which have been tested for specificity and cytotoxicity in vitro against melanoma (9.2.27 mab), leukaemia (WM60), colorectal (C30.6), breast (PAI2, herceptin), ovarian (PAI2, herceptin, C595), prostate (PAI2, J591) and pancreatic (PAI2, C595) cancers. Subcutaneous inoculation of 1–1.5 million human cancer cells into the flanks of nude mice causes tumours to grow in all mice. Tumour growth is compared for untreated controls, nonspecific AC and specific AC, for local (subcutaneous) and systemic (tail vein or intraperitoneal) injection models. The 213Bi-9.2.27 AC is injected into secondary skin melanomas in stage 4 patients in a dose escalation study to determine the effective tolerance dose, and to measure kinematics to obtain the equivalent dose to organs. In vitro studies show that TAT is one to two orders of magnitude more cytotoxic to targeted cells than non-specific ACs, specific beta emitting conjugates or free isotopes. In vivo local TAT at 2 days post-inoculation completely prevents tumour formation for all cancers tested so far. Intra-lesional TAT can completely regress advanced sc melanoma but is less successful for breast and prostate cancers. Systemic TAT inhibits the growth of sc melanoma xenografts and gives almost complete control of breast and prostate cancer tumour growth. Intralesional doses up to 450 µCi in human patients are effective in regressing melanomas, with no concomitant complications. These results point to the application of local and systemic TAT in the management of secondary cancer. Results of the phase 1 clinical trial of TAT of subcutaneous, secondary melanoma indicate proof of the principle that TAT can make tumours in patients regress.

Barry J Allen; Chand Raja; Syed Rizvi; Yong Li; Wendy Tsui; David Zhang; Emma Song; Chang Fa Qu; John Kearsley; Peter Graham; John Thompson

2004-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

A Framework for Improving the Quality of Cancer Care: The Case of Breast and Cervical Cancer Screening  

Science Journals Connector (OSTI)

...may be unaware of that risk or the opportunity to...transition from a woman at risk to one seeking appropriate...and are affected by the political, provider, payor...organization or health plan/insurance entity (Box B) and...individuals from environmental risks such as lead exposure...

Jane G. Zapka; Stephen H. Taplin; Leif I. Solberg; and M. Michele Manos

2003-01-01T23:59:59.000Z

402

Nucleic acid detection compositions  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Madison, WI); Lyamichev, Victor I. (Madison, WI); Brow, Mary Ann (Madison, WI); Dahlberg, James L. (Madison, WI)

2008-08-05T23:59:59.000Z

403

Opaque cloud detection  

DOE Patents [OSTI]

A method of detecting clouds in a digital image comprising, for an area of the digital image, determining a reflectance value in at least three discrete electromagnetic spectrum bands, computing a first ratio of one reflectance value minus another reflectance value and the same two values added together, computing a second ratio of one reflectance value and another reflectance value, choosing one of the reflectance values, and concluding that an opaque cloud exists in the area if the results of each of the two computing steps and the choosing step fall within three corresponding predetermined ranges.

Roskovensky, John K. (Albuquerque, NM)

2009-01-20T23:59:59.000Z

404

Supertruck - Improving Transportation Efficiency through Integrated...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Improving Transportation Efficiency through Integrated Vehicle, Engine and Powertrain Research Supertruck - Improving Transportation Efficiency through Integrated Vehicle, Engine...

405

Water Efficiency Improvements at Various Environmental Protection...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Water Efficiency Improvements at Various Environmental Protection Agency Sites Water Efficiency Improvements at Various Environmental Protection Agency Sites Water Efficiency...

406

Seminars in Cancer Biology 15 (2005) 484493 Dynamics of colorectal cancer  

E-Print Network [OSTI]

Seminars in Cancer Biology 15 (2005) 484­493 Review Dynamics of colorectal cancer Franziska Michora Abstract Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main

Nowak, Martin A.

407

Do cancer cells undergo phenotypic switching? The case for imperfect cancer  

E-Print Network [OSTI]

Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers Celoria 26, 20133 Milano, Italy. The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations

De Cindio, Fiorella

408

Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer  

E-Print Network [OSTI]

Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

Greenaway, Alan

409

Cancer Epidemiol Biomarkers Prev. Author manuscript Diet, cancer, and the lipidome  

E-Print Network [OSTI]

Cancer Epidemiol Biomarkers Prev. Author manuscript Page /1 8 Diet, cancer, and the lipidome Bougnoux Philippe 1 * , Giraudeau Bruno 2 , Couet Charles 1 Nutrition, Croissance et Cancer1 INSERM : E211 with the development of breast cancer by delaying its occurrence makes identification of defined molecules a mandatory

Paris-Sud XI, Université de

410

NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 HCIP class.  

E-Print Network [OSTI]

NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 by March 1st. Apply online! See website for further details. http://hcip.nci.nih.gov The National Cancer (NIH), is the Federal Government's principal agency for cancer research and training. The NCI

Cinabro, David

411

Mabs against Pancreatic cancer Therapeutic antibodies for the treatment of pancreatic cancer  

E-Print Network [OSTI]

Mabs against Pancreatic cancer 1 Therapeutic antibodies for the treatment of pancreatic cancer pancreatic cancer inserm-00497886,version1-6Jul2010 Author manuscript, published in "TheScientificWorldJournal (electronic resource) 2010;10:1107-20" DOI : 10.1100/tsw.2010.103 #12;Mabs against Pancreatic cancer 2

Paris-Sud XI, Université de

412

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens  

E-Print Network [OSTI]

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens in the world around us--as well as ways to avoid them When scientists talk about "environmental" causes of cancer are linked to as many as two out of every three cancers diagnosed. DeAnn Lazovich, Ph.D., M.P.H., is one

Minnesota, University of

413

Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy  

E-Print Network [OSTI]

with multifunctional theranostic capability show promising potential in cancer therapy.4 These nanomaterials can

Tan, Weihong

414

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network [OSTI]

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

415

Determinants of gonadal function after childhood cancer.  

E-Print Network [OSTI]

??abstract__Abstract__ Each year, 600–700 children are diagnosed with cancer in the Netherlands. Over the last decades, the overall long-term survival of childhood cancer has increased… (more)

W. van Dorp (Wendy)

2014-01-01T23:59:59.000Z

416

Physics of Cancer | Princeton Plasma Physics Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

18, 2014, 9:30am to 11:00am Science On Saturday MBG Auditorium Physics of Cancer Professor Wolfgang Losert, Associate Professor, and Director, Partnership for Cancer Technology...

417

Raw versus Cooked Vegetables and Cancer Risk  

Science Journals Connector (OSTI)

...study center, education, parity, energy, and alcohol intake but not for known...hypopharyngeal and esophageal cancer (Japan). Cancer Causes Control 2000;11...Hsu JP, Fry WG, Parker RP. Effect of household preparation on levels of pesticide residues...

Lilli B. Link and John D. Potter

2004-09-01T23:59:59.000Z

418

Detecting alien life forms  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Detecting alien life forms Detecting alien life forms Name: Brian S Foster Status: N/A Age: N/A Location: N/A Country: N/A Date: N/A Question: What would you do to find out if there is any life form on other planets? Replies: If you mean intelligent life, probably the best way would be to listen for radio messages, since you could do this from very far away. Earth emits as much radio energy as a small star --- very noticeable. If you mean just any kind of life it gets harder and you would have to send a robot or human in a spacecraft to visit. You could then look for the absorption of reflected light by oxygen molecules in the atmosphere. Oxygen is such a reactive molecule that it can only stay in the atmosphere if it is continually replenished by something, such as plants photosynthesizing. We cannot of course know that other life will build itself as does life on Earth, out of carbon-containing molecules which are formed by cracking apart carbon dioxide molecules with light energy (releasing oxygen). So the only sure way would probably be to land on the planet and look around. And even then you might well miss something

419

MULTIMOMENT RADIO TRANSIENT DETECTION  

SciTech Connect (OSTI)

We present a multimoment technique for signal classification and apply it to the detection of fast radio transients in incoherently dedispersed data. Specifically, we define a spectral modulation index in terms of the fractional variation in intensity across a spectrum. A signal whose intensity is distributed evenly across the entire band has a lower modulation index than a spectrum whose intensity is localized in a single channel. We are interested in broadband pulses and use the modulation index to excise narrowband radio frequency interference by applying a modulation index threshold above which candidate events are removed. The technique is tested both with simulations and using data from known sources of radio pulses (RRAT J1928+15 and giant pulses from the Crab pulsar). The method is generalized to coherent dedispersion, image cubes, and astrophysical narrowband signals that are steady in time. We suggest that the modulation index, along with other statistics using higher order moments, should be incorporated into signal detection pipelines to characterize and classify signals.

Spitler, L. G.; Cordes, J. M.; Chatterjee, S. [Astronomy Department and NAIC, Cornell University, Ithaca, NY 14853 (United States); Stone, J., E-mail: lspitler@astro.cornell.edu [Department of Physics and Astronomy, Barnard College, New York, NY 10027 (United States)

2012-04-01T23:59:59.000Z

420

Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer  

Science Journals Connector (OSTI)

...metastases, and the incidence of adverse events in the two groups were compared with the use of the chi-square test for heterogeneity or with Fisher’s exact test when appropriate. All statistical tests were two-sided, and P values of 0.05 or less were considered to indicate statistical significance. Odds... In patients with metastatic colon cancer, fluorouracil, oxaliplatin, and irinotecan plus bevacizumab, as compared with fluorouracil and irinotecan plus bevacizumab, improved progression-free and overall survival, with an increase in some side effects.

Loupakis F.; Cremolini C.; Masi G.

2014-10-23T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

improve | OpenEI Community  

Open Energy Info (EERE)

improve improve Home Dc's picture Submitted by Dc(15) Member 17 September, 2013 - 12:39 Are you willing to reply to a text message once a day with information about your comfort level at your indoor location? building comfort design improve incentive indoor message sms text Yes 60% (3 votes) No 0% (0 votes) Maybe if I had an incentive 20% (1 vote) Maybe if my reply is confidential and anonymous 0% (0 votes) Maybe if the data will be used to improve building design 20% (1 vote) Total votes: 5 Buildings account for roughly 40% of all U.S. energy use (70% of all electricity): residential buildings account for 22% of all U.S. energy use and commercial buildings account for 18% of all U.S. energy use[i]. There is an unanswered need for information about buildings in use and how building design affects building occupant comfort, productivity, and, by

422

Prescription to Improve Thermoelectric Efficiency  

E-Print Network [OSTI]

PRESCRIPTION TO IMPROVE THERMOELECTRIC EFFICIENCY A Thesis by SHIV AKARSH MEKA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... May 2010 Major Subject: Materials Science and Engineering PRESCRIPTION TO IMPROVE THERMOELECTRIC EFFICIENCY A Thesis by SHIV AKARSH MEKA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

Meka, Shiv Akarsh

2012-07-16T23:59:59.000Z

423

Cancer Epidemiology Population Health Sciences 750  

E-Print Network [OSTI]

-01/5/11-1 Cancer Epidemiology Population Health Sciences 750 3 credits When: Spring 2011 (1 Audience: This course is intended for students in health-related disciplines interested in cancer etiology. the unequal burden of cancer among populations and variations across time and geography, 2. the distinctive

Sheridan, Jennifer

424

Identifying Risk Groups Associated with Colorectal Cancer  

E-Print Network [OSTI]

Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

Jin, Huidong "Warren"

425

Eligibility: Cancer Survivor ages 35-75  

E-Print Network [OSTI]

Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

Walter, Peter

426

Fall/Winter CONCERNED ABOUT COLON CANCER?  

E-Print Network [OSTI]

TRADITIONS Fall/Winter 2005 #12;CONCERNED ABOUT COLON CANCER? PREVENTION IS POSSIBLE. Introducing the Colon C ancer Prevention Program at UConn Health C enter IT'S TRUE: C OLON CANCER MAY BE PREVENTED colon cancer prevention pl an sta rts w ith a phone call to the new Colon C an cer Prevention P r ogr am

Holsinger, Kent

427

Ion channels and apoptosis in cancer  

Science Journals Connector (OSTI)

...Issue Ion channels, transporters and cancer compiled and edited by Mustafa B. A...Albrecht Schwab Ion channels and apoptosis in cancer Carl D. Bortner John A. Cidlowski e-mail...Issue Ion channels, transporters and cancer . Humans maintain a constant cell number...

2014-01-01T23:59:59.000Z

428

miRNA Dysregulation in Breast Cancer  

Science Journals Connector (OSTI)

2013 American Association for Cancer Research. 15 November 2013 review-article Reviews miRNA Dysregulation in Breast Cancer Laoighse Mulrane Sharon F. McGee William...identified to incur increased risk of breast cancer in certain populations. In addition...

Laoighse Mulrane; Sharon F. McGee; William M. Gallagher; Darran P. O'Connor

2013-11-15T23:59:59.000Z

429

Casein Production by Human Breast Cancer  

Science Journals Connector (OSTI)

...human breast cancers. Casein production by human breast cancer...Thus it appears that casein production is not a common characteristic...magnesium, by scraping with a rubber policeman and collected by...sulfate. MARCH 1977 749 Casein Production by Human Breast Cancer Marie...

Marie E. Monaco; Diane A. Bronzert; Douglass C. Tormey; Phillip Waalkes; and Marc E. Lippman

1977-03-01T23:59:59.000Z

430

Energy Balance and Breast Cancer Risk  

Science Journals Connector (OSTI)

...Zhu Z, Jiang W. Dietary energy restriction in breast cancer...induced in mammary carcinomas by energy restriction. Cancer Res 2004...the effect of World War II in Norway. Cancer Causes Control 1996...Determinants of 24-hour energy expenditure in man. Methods...

Alecia Malin; Charles E. Matthews; Xiao-Ou Shu; Hui Cai; Qi Dai; Fan Jin; Yu-Tang Gao; and Wei Zheng

2005-06-01T23:59:59.000Z

431

Improving Methods to Mimic In Vivo Tissue in a Microfluidic Device That is Used to Test Chemotherpeutic Drugs Using  

E-Print Network [OSTI]

Improving Methods to Mimic In Vivo Tissue in a Microfluidic Device That is Used to Test components of a microfluidic device that mimics in vivo environments used for chemotherapeutic testing. I) serve as a model for in vivo cancerous tumors. MCTS will be used in a microfluidic device that mimics

Mountziaris, T. J.

432

Techniques and Technologies for Field Detection of Asbestos Containing Materials  

Broader source: Energy.gov (indexed) [DOE]

DOE-Environmental Management DOE-Complex Wide Techniques and Technologies for Field Detection of Asbestos Containing Materials Challenge Asbestos has been used in numerous applications at DOE sites including sprayed-on fireproofing, asphalt and vinyl floor tile, and asbestos-cement (transite) siding. Inhalation of asbestos can result in non-malignant asbestosis, lung cancer and mesothelioma in workers. Currently, 40 CFR 763, Subpart E requires a certain number of bulk samples of suspected asbestos-containing material (ACM) to be collected within each designated homogeneous area (HA). If real time (or near-real), in-situ detection techniques/technologies of ï‚£ 5, and preferably ï‚£ 3 weight percent asbestos, were available, sample numbers

433

Testicular Cancer — Discoveries and Updates  

Science Journals Connector (OSTI)

...-node dissection after chemotherapy can be avoided in approximately 95% of men if patients with a complete response on serologic and radiographic testing are followed with active surveillance. Stage III Testicular Cancer. The discovery of cis-diamminedichloroplatinum (known as cisplatin) in 1965, a landmark... The treatment of testicular cancer is a success story in oncology. With available methods, 95% of men with this condition can be cured. Emphasis is shifting toward maintaining high cure rates and reducing or effectively managing late effects of treatment.

Hanna N.H.; Einhorn L.H.

2014-11-20T23:59:59.000Z

434

Costbased Modeling for Fraud and Intrusion Detection: Results from the JAM Project  

E-Print Network [OSTI]

Cost­based Modeling for Fraud and Intrusion Detection: Results from the JAM Project Salvatore J the results achieved using the JAM distributed data mining system for the real world prob­ lem of fraud­of­the­art commercial fraud detection systems can be substantially improved in stopping losses due to fraud by combining

Lee, Wenke

435

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version  

E-Print Network [OSTI]

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

Boyer, Edmond

436

Comparing readout strategies to directly detect dark matter  

E-Print Network [OSTI]

Over the past decades, several ideas and technologies have been developed to directly detect WIMP from the galactic halo. All these detection strategies share the common goal of discriminating a WIMP signal from the residual backgrounds. By directly detecting WIMPs, one can measure some or all of the observables associated to each nuclear recoil candidates, such as their energy and direction. In this study, we compare and examine the discovery potentials of each readout strategies from counting only (bubble chambers) to directional detectors (Time Projection Chambers) with 1d-, 2d-, and 3d-sensitivity. Using a profile likelihood analysis, we show that, in the case of a large and irreducible background contamination characterized by an energy distribution similar to the expected WIMP signal, directional information can improve the sensitivity of the experiment by several orders of magnitude. We also found that 1d directional detection is only less effective than a full 3d directional sensitivity by about a fac...

Billard, J

2014-01-01T23:59:59.000Z

437

Arc fault detection system  

DOE Patents [OSTI]

An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard.

Jha, Kamal N. (Bethel Park, PA)

1999-01-01T23:59:59.000Z

438

Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial  

E-Print Network [OSTI]

cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

2010-01-01T23:59:59.000Z

439

SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer.  

E-Print Network [OSTI]

??Second only to lung cancer, breast cancer is the leading cause of cancer-related deaths in American women. Breast cancer is a heterogeneous set of diseases… (more)

Stovall, Daniel B.

2014-01-01T23:59:59.000Z

440

The Energy Detective | Open Energy Information  

Open Energy Info (EERE)

Detective Jump to: navigation, search Name: The Energy Detective Place: Charleston, SC Website: http:www.theenergydetective. References: The Energy Detective1 Information About...

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study  

SciTech Connect (OSTI)

Purpose: We have previously shown that the addition of cetuximab to chemoradiation therapy failed to improve complete response rates (pCR) in rectal cancer. Here we report the long-term results of the cetuximab added to preoperative radiation therapy with capecitabine and oxaliplatin (CET-CAPOX-RT) phase 1/2 study that evaluated preoperative chemoradiation with cetuximab, capecitabine, and oxaliplatin in patients with rectal cancer. Methods and Materials: The median follow-up was 63 months (range, 5-73 months). Sixty patients were enrolled; 3 patients were excluded due to protocol violation, and 4 died before surgery. Total mesorectal excision was performed in 53 patients, in 85% (n=45) with curative intention (M0-status). Secondary end points including overall survival (OS) disease-free survival (DFS) and cancer-specific survival (CSS) were calculated. The prognostic value of KRAS mutation status was also assessed. Results: Histopathological examination confirmed ypUICC stages 0 (n=4; pCR), I (n=17), II (n=10), III (n=14), and IV (n=8). For patients who underwent surgery (n=53), OS at 1, 3, and 5 years was 88.7%, 83%, and 75.5%, respectively, whereas CSS rates were 94.1%, 88.1%, and 78.1%, respectively. In the 45 patients who were treated with curative intent (M0), the OS rates at 1, 3, and 5 years were 91.1%, 88.9%, and 86.7%, respectively; whereas CSS rates were 97.6%, 95.2%, and 90.3%, respectively; and DFS rates were 90.7%, 88.3%, and 88.3%, respectively. We did not find any locoregional failure in patients with M0-status (n=45). Chronic toxicity was rare. KRAS mutations, as detected in 33.3%, showed no correlation with the clinicopathological parameters nor significance for either OS (P=.112), CSS (P=.264), or DFS (P=.565). Conclusions: Taken together, chemoradiation therapy combined with cetuximab is safe, feasible, and offers excellent survival rates. KRAS mutation status was not a predictive factor. Importantly, lack of improvement in pCR rate did not translate to poor survival in our clinical trial.

Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Conradi, Lena [Department of General Surgery, University Medical Center of Göttingen (Germany); Weiss, Christian [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Sprenger, Thilo [Department of General Surgery, University Medical Center of Göttingen (Germany); Middel, Peter [Institute for Pathology, University Medical Center, Göttingen (Germany); Rau, Tillman [Institute of Pathology, University Hospital Erlangen, Erlangen (Germany); Dellas, Kathrin [Department of Radiotherapy, Lübeck University (Germany); Kitz, Julia [Institute for Pathology, University Medical Center, Göttingen (Germany); Rödel, Franz [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Sauer, Rolf [Department of Radiation Oncology, University of Erlangen (Germany); Rüschoff, Josef [Targos Molecular Pathology, Kassel (Germany); Beissbarth, Tim [Department of Medical Statistics, University Medical Center of Göttingen (Germany); Arnold, Dirk [Tumor Biology Center Freiburg, University of Freiburg (Germany); Ghadimi, B. Michael [Department of General Surgery, University Medical Center of Göttingen (Germany); Rödel, Claus [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Liersch, Torsten [Department of General Surgery, University Medical Center of Göttingen (Germany)

2013-12-01T23:59:59.000Z

442

A Protein that Repairs Damage to Cancer Cells | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

An X-ray Vortex on the Horizon? An X-ray Vortex on the Horizon? How Two Drops Become One Scientists Discover How Nanocluster Contaminants Increase Risk of Spreading Mobile RNA is Poised and Ready Glass Does a Double-Take Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Protein that Repairs Damage to Cancer Cells MAY 5, 2008 Bookmark and Share The ABH2-DNA complex. A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells. Because one of the proteins detects and repairs DNA damage that may result from a certain type of cancer therapy, the researchers raised the possibility of designing a molecule that could interfere with the repair process, making cancer

443

AACR Cancer Progress Report 2014  

Science Journals Connector (OSTI)

...research has been central to the personalized cancer medicine revolution. This new knowledge is now beginning to be used to reform how clinical trials are designed and conducted. As we look to the future, we can expect to see greater deployment of genomics...

Carlos L. Arteaga; Peter C. Adamson; Jeffrey A. Engelman; Margaret Foti; Richard B. Gaynor; Susan G. Hilsenbeck; Paul J. Limburg; Scott W. Lowe; Elaine R. Mardis; Scott Ramsey; Timothy R. Rebbeck; Andrea L. Richardson; Eric H. Rubin; George J. Weiner; Shawn M. Sweeney; Karen Honey; Jenna Bachen; Paul Driscoll; Jennifer Hobin; James Ingram; Rasika Kalamegham; Richard Lobb; Jon G. Retzlaff; Mary Lee Watts; Nicolle Rager Fuller

2014-10-01T23:59:59.000Z

444

Do Cell Phones Cause Cancer?  

E-Print Network [OSTI]

Do cell phones, household electrical power wiring or appliance, or high voltage power lines cause cancer? Fuggedaboudit! No way! When pigs fly! When I'm the Pope! Don't text while you're driving, however, or eat your cell phone. All organisms absorb microwave radiation directly as thermal energy. In living organisms, the organisms' thermal control systems, including the blood flow, and various cooling mechanisms, such as sweating in humans, that work to maintain a stable body temperature rapidly transfer the absorbed energy to the environment. Any temperature rise is small or even unobserved. Any proposed mechanism by which cell phone radiation might cause cancer must begin with this fact. But the amount of radiation absorbed from a cell phone is less than that produced by normal metabolic processes, and much less than that produced by, for example, exercise. None of these normal metabolic processes cause cancer. Therefore, the much smaller amounts of energy from cell phones doesn't cause cancer either. All f...

Leikind, Bernard

2010-01-01T23:59:59.000Z

445

Epidemiology of Male Breast Cancer  

Science Journals Connector (OSTI)

...electricians, telephone linemen, and electric power workers. Similarly...repair, and manufacturing of motor vehicles (65, 92, 95, 105...571-80. 90 Stevens RG. Electric power use and breast cancer...exposure to magnetic fields among electric utility workers in Ontario...

Joli R. Weiss; Kirsten B. Moysich; and Helen Swede

2005-01-01T23:59:59.000Z

446

Erythropoietin and Ovarian Cancer – Response  

Science Journals Connector (OSTI)

...Ovarian Cancer - Response Peter Solar Jan Koval Jaromir Mikes Jan...Harvard Medical School, Boston, Massachusetts We have read with interest...were disclosed. References 1 Solar P , Koval J, Mikes J, et...2 Jeong JY , Feldman L, Solar P, Szenajch J, Sytkowski...

Peter Solár; Ján Koval; Jaromír Mikeš; Ján Kleban; Zuzana Solárová; Ján Lazúr; Ingrid Hodorová; Peter Fedoro?ko; and Arthur J. Sytkowski

2010-04-01T23:59:59.000Z

447

Link between obesity and cancer  

Science Journals Connector (OSTI)

...University of Miami, Florida. “Everyone’s heard...decade. As obesity rates soar around the...understanding of how fat fuels cancer. Sea of Fat Cells At...are more than inert energy stores. Adipocytes...cells grow and use energy, and it makes sense, says Hursting...under stress and add fuel to the fire...

Sarah C. P. Williams

2013-01-01T23:59:59.000Z

448

Abstract B21: Disruption of NF?B/Stat3 interaction as a potential therapeutic avenue for pancreatic cancer management.  

Science Journals Connector (OSTI)

...Clinical and Biological Sciences, University of Torino...Stage Lung Cancer-New Approaches to Evaluation and Treatment...surgery, and basic science were presented from...prognosis, and appropriate management of screen-detected...these models. Promising approaches include gene expression...

Jingjing Gong; Jianping Xie; Izhar Batth; James W. Freeman; Divya Chakravarthy; and Addanki pratap Kumar

2012-07-15T23:59:59.000Z

449

Activation of Proteinase-Activated Receptor 1 Promotes Human Colon Cancer Cell Proliferation Through Epidermal Growth Factor Receptor Transactivation  

Science Journals Connector (OSTI)

...antibody for 1 hour at room temperature before detection using chemiluminescence...ectodomain shedding in mammalian development. Science 1998;282:1281-4...cells and its inhibition by snake venom peptides, trigramin...crucial contributors to the development of human colon cancer. We...

Dalila Darmoul; Valérie Gratio; Hélène Devaud; Franck Peiretti; and Marc Laburthe

2004-09-01T23:59:59.000Z

450

An Improved Tissue Culture System  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Improved Improved Tissue Culture System for Embryogenic Callus Production and Plant Regeneration in Switchgrass (Panicum virgatum L.) Jason N. Burris & David G. J. Mann & Blake L. Joyce & C. Neal Stewart Jr. Published online: 10 October 2009 # Springer Science + Business Media, LLC. 2009 Abstract The increased emphasis on research of dedicated biomass and biofuel crops begs for biotechnology method improvements. For switchgrass (Panicum virgatum L.), one limitation is inefficient tissue culture and transformation systems. The objectives of this study were to investigate the utility of a new medium described here, LP9, for the production and maintenance of switchgrass callus and its regeneration, which also enables genetic transformation. LP9 medium is not based on Murashige and Skoog (MS) medium, the basal medium that all published switchgrass transformation has been

451

HVAC Improvements for Existing Houses  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HVAC Improvements for Existing Houses HVAC Improvements for Existing Houses Speaker(s): Chryséis Bovagnet Date: September 5, 2002 - 12:00pm Location: Bldg. 90 Many older houses in the US are either not well designed from a thermal point of view or have HVAC (Heating Ventilation and Air Conditioning) systems in need of repairs or improvements. The building envelopes tend to have poor insulation and lots of leakage, and the HVAC systems are inefficient. The cooling/heating equipment is often located outside of the conditioned space (e.g. in attics or crawlspaces) with ducts that leak and have poor insulation, which cause energy loss and bad occupant comfort on peak days or in extreme climates. We developed a series of retrofits that will allow us to reduce the energy consumption of residential HVAC

452

Improving Process Cooling Tower Eddiciency  

E-Print Network [OSTI]

of the Thrity-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 7 Improving Cooling Tower Efficiency ? Two Improvements in Capacity/Performance 1. Filtration for water quality control Side stream filtration Make up water quality...-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 2 Types of Cooling Towers Forced Draft Towers ESL-IE-13-05-08 Proceedings of the Thrity-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 3 Types...

Turpish, W.

2013-01-01T23:59:59.000Z

453

Incipient fire detection system  

DOE Patents [OSTI]

A method and apparatus for an incipient fire detection system that receives gaseous samples and measures the light absorption spectrum of the mixture of gases evolving from heated combustibles includes a detector for receiving gaseous samples and subjecting the samples to spectroscopy and determining wavelengths of absorption of the gaseous samples. The wavelengths of absorption of the gaseous samples are compared to predetermined absorption wavelengths. A warning signal is generated whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. The method includes receiving gaseous samples, subjecting the samples to light spectroscopy, determining wavelengths of absorption of the gaseous samples, comparing the wavelengths of absorption of the gaseous samples to predetermined absorption wavelengths and generating a warning signal whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. In an alternate embodiment, the apparatus includes a series of channels fluidically connected to a plurality of remote locations. A pump is connected to the channels for drawing gaseous samples into the channels. A detector is connected to the channels for receiving the drawn gaseous samples and subjecting the samples to spectroscopy. The wavelengths of absorption are determined and compared to predetermined absorption wavelengths is provided. A warning signal is generated whenever the wavelengths correspond.

Brooks, Jr., William K. (Newport News, VA)

1999-01-01T23:59:59.000Z

454

Fraud detection using data mining .  

E-Print Network [OSTI]

??Fraud is a major problem in South Africa and the world and organisations lose millions each year to fraud not being detected. Organisations can deal… (more)

Pienaar, Abel Jacobus

2014-01-01T23:59:59.000Z

455

Heat Kernel Based Community Detection  

E-Print Network [OSTI]

Heat Kernel Based. Community Detection. Kyle Kloster. Purdue University. Joint with. David F. Gleich,. (Purdue), supported by. NSF CAREER. 1149756-CCF ...

2014-09-16T23:59:59.000Z

456

Role of Adjuvant Chemoradiotherapy for Ampulla of Vater Cancer  

SciTech Connect (OSTI)

Purpose: To evaluate the role of adjuvant chemoradiotherapy for ampulla of Vater cancer. Methods and Materials: Between January 1991 and December 2002, 118 patients with ampulla of Vater cancer underwent en bloc resection. Forty-one patients received adjuvant chemoradiotherapy [RT(+) group], and 77 did not [RT(-) group]. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes, for a total dose of up to 40 Gy delivered in 2-Gy fractions, with a planned 2-week rest period halfway through the treatment period. Intravenous 5-fluorouracil (500 mg/m{sup 2}/day) was given on Days 1 to 3 of each split course. The median follow-up was 65 months. Results: The 5-year overall survival rate in the RT(-) and RT(+) groups was 66.9% and 52.8%, respectively (p = 0.2225). The 5-year locoregional relapse-free survival rate in the RT(-) and RT(+) groups was 79.9% and 80.2%, respectively (p = 0.9582). When age, type of operation, T stage, N stage, histologic differentiation, and the use of adjuvant chemoradiotherapy were incorporated into the Cox proportional hazard model, there was an improvement in the locoregional relapse-free survival rate (p = 0.0050) and a trend toward a longer overall survival (p = 0.0762) associated with the use of adjuvant chemoradiotherapy. Improved overall survival (p = 0.0235) and locoregional relapse-free survival (p = 0.0095) were also evident in patients with nodal metastasis. In contrast, enhanced locoregional control (p = 0.0319) did not result in longer survival in patients with locally advanced disease (p = 0.4544). Conclusions: Adjuvant chemoradiotherapy may enhance locoregional control and overall survival in patients with ampulla of Vater cancer after curative resection, especially in those with nodal involvement.

Kim, Kyubo [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Chie, Eui Kyu [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of)], E-mail: ekchie93@snu.ac.kr; Jang, Jin-Young; Kim, Sun Whe [Department of Surgery, Seoul National University College of Medicine, Seoul (Korea, Republic of); Oh, Do-Youn; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue [Department of Internal Medicine, Seoul National University College of Medicine, Seoul (Korea, Republic of); Ha, Sung W. [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)

2009-10-01T23:59:59.000Z

457

Improved outcome of nasopharyngeal carcinoma treated with conventional radiotherapy  

SciTech Connect (OSTI)

Purpose: To describe the outcome of patients with nonmetastatic nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy at a single institution. Methods and materials: From 1990 to 1999, 171 consecutive patients with NPC were treated with conventional (two-dimensional) radiotherapy. Tumor histology was undifferentiated in 82% of cases. Tumor-node-metastasis Stage (American Joint Committee on Cancer/International Union Against Cancer 1997 system) was I in 6%, II in 36%, III in 22%, and IV in 36% of patients. Mean total radiation dose was 68.4 Gy. Chemotherapy was given to 62% of the patients. The median follow-up for surviving patients was 6.3 years (range, 3.1-13.1 years). Results: The 5-year overall survival, disease-specific survival, and disease-free survival rates were 72%, 74%, and 62%, respectively. The 5-year local, regional, and distant control rates were 84%, 80%, and 83% respectively. Late effects of radiotherapy were prospectively recorded in 100 patients surviving without relapse; 44% of these patients had Grade 3 xerostomia, 33% had Grade 3 dental damage, and 11% had Grade 3 hearing loss. Conclusions: This analysis shows an improved outcome for patients treated from 1990 to 1999 compared with earlier retrospective series, despite the use of two-dimensional radiotherapy. Late toxicity, however, was substantial with conventional radiotherapy.

Palazzi, Mauro [Department of Radiotherapy, Istituto Nazionale Tumori, Milan (Italy)]. E-mail: mauro.palazzi@istitutotumori.mi.it; Guzzo, Marco [Department of Head and Neck Surgery, Istituto Nazionale Tumori, Milan (Italy); Tomatis, Stefano Ph.D. [Unit of Medical Physics, Istituto Nazionale Tumori, Milan (Italy); Cerrotta, Annamaria [Department of Radiotherapy, Istituto Nazionale Tumori, Milan (Italy); Potepan, Paolo [Department of Radiology, Istituto Nazionale Tumori, Milan (Italy); Quattrone, Pasquale [Department of Pathology, Istituto Nazionale Tumori, Milan (Italy); Cantu, Giulio [Department of Head and Neck Surgery, Istituto Nazionale Tumori, Milan (Italy)

2004-12-01T23:59:59.000Z

458

Measuring and Improving Cell Capability  

E-Print Network [OSTI]

Measuring and Improving Cell Capability by Tom Bering Rate Parts / Hour Parts / Car Good Parts 1000 ppm defects/part 1 ppm defects/part 0.1 ppm defects/part 0.001 ppm defects/part 3600 Good Parts / Hour Defect Every 20 Min. Defect Every 2 Weeks Defect Every 20 Weeks Defect Every 40 Years 5000 Good Parts = 1

Bone, Gary

459

Managing Critical Management Improvement Initiatives  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Provides requirements and responsibilities for planning, executing and assessing critical management improvement initiatives within DOE. DOE N 251.59, dated 9/27/2004, extends this Notice until 10/01/2005. Archived 11-8-10. Does not cancel other directives.

2003-10-01T23:59:59.000Z

460

Sustaining Performance Improvements in Energy Intensive Industries  

E-Print Network [OSTI]

Experience has shown that significant opportunity for performance improvements exists in energy intensive operations. Often, efforts to improve efficiency focus on vendor-led initiatives to improve operations of particular equipment. This approach...

Moore, D. A.

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Cancer in Ireland 1994-2004: A comprehensive report  

E-Print Network [OSTI]

Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

Müller, Jens-Dominik

462

PrincetonUniversity In-Vitro Studies of Cancer  

E-Print Network [OSTI]

PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

Petta, Jason

463

Real-time system for imaging and object detection with a multistatic GPR array  

DOE Patents [OSTI]

A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

Paglieroni, David W; Beer, N Reginald; Bond, Steven W; Top, Philip L; Chambers, David H; Mast, Jeffrey E; Donetti, John G; Mason, Blake C; Jones, Steven M

2014-10-07T23:59:59.000Z

464

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer  

SciTech Connect (OSTI)

Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

Zeng Hui [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Yuan Zhu [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Zhu Hong [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Lei; Shi Huashan [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Xiao Jianghong [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Zhiping, E-mail: lizhiping620312@yahoo.com.cn [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)

2012-11-15T23:59:59.000Z

465

Smart Grid Investments Improve Grid Reliability, Resilience,...  

Energy Savers [EERE]

Investments Improve Grid Reliability, Resilience, and Storm Responses (November 2014) Smart Grid Investments Improve Grid Reliability, Resilience, and Storm Responses (November...

466

Industrial Energy Efficiency Projects Improve Competitiveness...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Industrial Energy Efficiency Projects Improve Competitiveness and Protect Jobs Industrial Energy Efficiency Projects Improve Competitiveness and Protect Jobs U.S. Department of...

467

Funding Opportunity Webinar - Advancing Solutions To Improve...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Funding Opportunity Webinar - Advancing Solutions To Improve the Energy Efficiency of US Commercial Buildings Funding Opportunity Webinar - Advancing Solutions To Improve the...

468

Advanced Manufacturing Initiative Improves Turbine Blade Productivity...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Advanced Manufacturing Initiative Improves Turbine Blade Productivity Advanced Manufacturing Initiative Improves Turbine Blade Productivity May 20, 2011 - 2:56pm Addthis This is an...

469

2012 Quality Assurance Improvement Project Plan | Department...  

Office of Environmental Management (EM)

2 Quality Assurance Improvement Project Plan 2012 Quality Assurance Improvement Project Plan This Project Plan is jointly developed by the Department of Energy (DOE) Office of...

470

Water Efficiency Improvements at Various Environmental Protection...  

Broader source: Energy.gov (indexed) [DOE]

Water Efficiency Improvements at Various Environmental Protection Agency Sites: Best Management Practices Case Study 12-LaboratoryMedical Equipment Water Efficiency Improvements...

471

Abuse Tolerance Improvements | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Improvements Abuse Tolerance Improvements 2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting...

472

Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer  

Science Journals Connector (OSTI)

...aacrjournals.org/). This study is the first to define a long noncoding RNA that regulates...and in situ hybridization (ISH) analyses to identify aberrantly expressed lncRNA in...of recurrence and metastasis (1, 2 ). To improve gastric cancer early diagnosis and...

Ye Hu; Jilin Wang; Jin Qian; Xuan Kong; Jieting Tang; Yingchao Wang; Haoyan Chen; Jie Hong; Weiping Zou; Yingxuan Chen; Jie Xu; Jing-Yuan Fang

2014-12-01T23:59:59.000Z

473

2005LANDESBIOSCIENCE.DONOTDISTRIBUTE. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; 2005 Landes Bioscience  

E-Print Network [OSTI]

not improved long-term survival after resection. -lapachone is a naturally occurring compound presentRadiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa City, Iowa USA 6Departments of Radiation

Gao, Jinming

474

Supernova Neutrinos Detection On Earth  

E-Print Network [OSTI]

In this paper, we first discuss the detection of supernova neutrino on Earth. Then we propose a possible method to acquire information about $\\theta_{13}$ smaller than $1.5^\\circ$ by detecting the ratio of the event numbers of different flavor supernova neutrinos. Such an sensitivity cannot yet be achieved by the Daya Bay reactor neutrino experiment.

Xin-Heng Guo; Ming-Yang Huang; Bing-Lin Young

2009-05-12T23:59:59.000Z

475

"Dancing Icons" Detection Itamar Friedman  

E-Print Network [OSTI]

"Dancing Icons" Detection Itamar Friedman Technion Haifa, Israel ItamarF@tx.technion.ac.il Lihi these particular applications could be by taking a photo of their corresponding icons as displayed on our friend's screen. We then need to develop methods for au- tomatic detection and recognition of the icons

Zelnik-Manor, Lihi - Zelnik-Manor, Lihi

476

Global modeling of cancer gene expression signa-Cancer leads to permanent changes in cell's physiological state and various  

E-Print Network [OSTI]

Global modeling of cancer gene expression signa- tures Cancer leads to permanent changes in cell cancer types. Less is known about the underlying biological processes, or relationships between different cancer types with respect to these changes. While each specific cancer type has a set of unique

Kaski, Samuel

477

Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1  

E-Print Network [OSTI]

Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Cancer Research UK electronic Grants Management System (e://egms.cancerresearchuk.org #12;Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 2

478

Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: The Population Architecture using Genomics and Epidemiology Study  

Science Journals Connector (OSTI)

...Chicago, IL Abstract 5087: UCSC Cancer Genomics Browser 2.0 Jingchun Zhu 1 Brian Craft...and analyze that data. The UCSC Cancer Genomics Browser (https://genome-cancer...enhances the interpretability of the cancer genomics information. UCSC Cancer Genomics Browser...

S. Lani Park; Christian P. Caberto; Yi Lin; Robert J. Goodloe; Logan Dumitrescu; Shelly-Ann Love; Tara C. Matise; Lucia A. Hindorff; Jay H. Fowke; Fredrick R. Schumacher; Jennifer Beebe-Dimmer; Chu Chen; Lifang Hou; Fridtjof Thomas; Ewa Deelman; Ying Han; Ulrike Peters; Kari E. North; Gerardo Heiss; Dana C. Crawford; Christopher A. Haiman; Lynne R. Wilkens; William S. Bush; Charles Kooperberg; Iona Cheng; Loïc Le Marchand

2014-11-01T23:59:59.000Z

479

DOE Mobile Detection Assessment Response System (MDARS)  

Broader source: Energy.gov (indexed) [DOE]

Helps Pioneer "Robot" Patrol Technology: Deployment of the Helps Pioneer "Robot" Patrol Technology: Deployment of the DOE Mobile Detection Assessment Response System (MDARS) The use of patrol robots to cost effectively improve security while reducing health and safety risks at DOE and NNSA nuclear facilities is an HSS advanced technology deployment "first". Over the past 2 years, the HSS Office of Technology has played a key role in working with the Army, the National Nuclear Security Administration (NNSA), the Nevada National Security Site (NNSS) and General Dynamics Robotics Systems to purchase, prototype, test and deploy the first of three MDARS patrol robots at NNSS. In addition to the initial purchase, HSS successfully negotiated a mutually acceptable

480

Rapid deployment intrusion detection system  

SciTech Connect (OSTI)

A rapidly deployable security system is one that provides intrusion detection, assessment, communications, and annunciation capabilities; is easy to install and configure; can be rapidly deployed, and is reusable. A rapidly deployable intrusion detection system (RADIDS) has many potential applications within the DOE Complex: back-up protection for failed zones in a perimeter intrusion detection and assessment system, intrusion detection and assessment capabilities in temporary locations, protection of assets during Complex reconfiguration, and protection in hazardous locations, protection of assets during Complex reconfiguration, and protection in hazardous locations. Many DOE user-need documents have indicated an interest in a rapidly deployable intrusion detection system. The purpose of the RADIDS project is to design, develop, and implement such a system. 2 figs.

Graham, R.H.

1997-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Better postdiagnosis diet quality is associated with less cancer-related fatigue in breast cancer survivors  

Science Journals Connector (OSTI)

A comprehensive understanding of the role of modifiable health behaviors in effective management of cancer-related fatigue is needed. Among breast cancer survivors, we examined how postdiagnosis diet quality, ...

Stephanie M. George; Catherine M. Alfano…

2014-12-01T23:59:59.000Z

482

Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition  

Science Journals Connector (OSTI)

...Care, University Medical Center Utrecht, Utrecht, the Netherlands; 21 Cancer Epidemiology...esophageal cancer. Methods: We applied multivariable adjusted Cox proportional...spouses), and the cohorts in Utrecht (the Netherlands) and Florence...

Annika Steffen; Matthias B. Schulze; Tobias Pischon; Thomas Dietrich; Esther Molina; Maria-Dolores Chirlaque; Aurelio Barricarte; Pilar Amiano; J. Ramón Quirós; Rosario Tumino; Amalia Mattiello; Domenico Palli; Paolo Vineis; Claudia Agnoli; Gesthimani Misirli; Paolo Boffetta; Rudolf Kaaks; Sabine Rohrmann; H. Bas Bueno-de-Mesquita; Petra H.M. Peeters; Anne M. May; Elizabeth A. Spencer; Naomi E. Allen; Sheila Bingham; Anne Tjønneland; Jytte Halkjær; Kim Overvad; Jakob Stegger; Jonas Manjer; Björn Lindkvist; Göran Hallmanns; Roger Stenling; Eiliv Lund; Elio Riboli; Carlos A. Gonzalez; and Heiner Boeing

2009-07-01T23:59:59.000Z

483

Cancer Prevention for Global Health: A Report from the ASPO International Cancer Prevention Interest Group  

Science Journals Connector (OSTI)

...Africa. Data from International Atomic Energy Agency indicate that there is insufficient...protected time limits the ability to create sustainable research. In addition, research, education...to make the cancer research enterprise sustainable. Summary In conclusion, cancer is an...

Dejana Braithwaite; Paolo Boffetta; Timothy R. Rebbeck; and Frank Meyskens

2012-09-01T23:59:59.000Z

484

Oral complications in cancer patients  

SciTech Connect (OSTI)

Ionizing radiation used in treating the head and neck area produces oral side effects such as mucositis, salivary changes, trismus and radiation caries. Sequelae of cancer chemotherapy often include oral stomatitis, myelosuppression and immunosuppression. Infections of dental origin in compromised patients are potentially lethal. Specific programs to eliminate dental pathology before radiation and chemotherapy, and to maintain oral hygiene during and after therapy, will minimize these complications.

Carl, W.

1983-02-01T23:59:59.000Z

485

Magnetic force microscopy method and apparatus to detect and image currents in integrated circuits  

DOE Patents [OSTI]

A magnetic force microscopy method and improved magnetic tip for detecting and quantifying internal magnetic fields resulting from current of integrated circuits. Detection of the current is used for failure analysis, design verification, and model validation. The interaction of the current on the integrated chip with a magnetic field can be detected using a cantilevered magnetic tip. Enhanced sensitivity for both ac and dc current and voltage detection is achieved with voltage by an ac coupling or a heterodyne technique. The techniques can be used to extract information from analog circuits.

Campbell, Ann. N. (13170-B Central SE #188, Albuquerque, NM 87123); Anderson, Richard E. (2800 Tennessee NE, Albuquerque, NM 87110); Cole, Jr., Edward I. (2116 White Cloud NE, Albuquerque, NM 87112)

1995-01-01T23:59:59.000Z

486

Magnetic force microscopy method and apparatus to detect and image currents in integrated circuits  

DOE Patents [OSTI]

A magnetic force microscopy method and improved magnetic tip for detecting and quantifying internal magnetic fields resulting from current of integrated circuits are disclosed. Detection of the current is used for failure analysis, design verification, and model validation. The interaction of the current on the integrated chip with a magnetic field can be detected using a cantilevered magnetic tip. Enhanced sensitivity for both ac and dc current and voltage detection is achieved with voltage by an ac coupling or a heterodyne technique. The techniques can be used to extract information from analog circuits. 17 figs.

Campbell, A.N.; Anderson, R.E.; Cole, E.I. Jr.

1995-11-07T23:59:59.000Z

487

Steam Cracker Furnace Energy Improvements  

E-Print Network [OSTI]

Channel, ~ 25 mi. east of Houston ? Includes 4 manufacturing sites, 2 technology/engineering offices ?Significant community involvement Baytown Refinery Page 4 Steam Cracking to Olefins ? Process 60+ years old; ExxonMobil one of pioneers... Steam Cracker Furnace Energy Improvements Tim Gandler Energy Coordinator Baytown Olefins Plant, Baytown Tx 2010 Industrial Energy Technology Conference May, 2010 Page 2 ? Baytown Complex ? Steam Cracking to Olefins ? Furnace overview...

Gandler, T.

488

LOS ANGELES, CA, DISTRICT IMPROVEMENTS  

E-Print Network [OSTI]

33-1 LOS ANGELES, CA, DISTRICT IMPROVEMENTS Navigation Page 1. Channel Islands Harbor, CA 33-2 2. Imperial Beach, Silver Strand Shoreline, CA 33-2 3. LA-LB Harbors (LA Harbor), CA 33-2 4. Los Angeles Harbor Main Channel Deepen, CA 33-2 5. Marina Del Rey, CA 33-3 6. Morro Bay Harbor, CA 33-3 7. Newport

US Army Corps of Engineers

489

Chromosome-Specific Staining To Detect Genetic Rearrangements Associated With Chromosome 3 And/Or Chromosone 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray; Joe W. (Livermore, CA); Pinkel; Daniel (Walnut Creek, CA); Kallioniemi; Olli-Pekka (Tampere, FI); Kallioniemi; Anne (Tampere, FI); Sakamoto; Masaru (Tokyo, JP)

2002-02-05T23:59:59.000Z

490

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2008-09-09T23:59:59.000Z

491

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nudeic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Kallioniemi, Olli-Pekka (Tampere, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2002-01-01T23:59:59.000Z

492

Genome Science and Personalized Cancer Treatment  

ScienceCinema (OSTI)

August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

Joe Gray

2010-01-08T23:59:59.000Z

493

Genome Science and Personalized Cancer Treatment  

SciTech Connect (OSTI)

August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

Joe Gray

2009-08-07T23:59:59.000Z

494

Genome Science and Personalized Cancer Treatment  

SciTech Connect (OSTI)

Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

Gray, Joe

2009-08-04T23:59:59.000Z

495

Cancer evolution: mathematical models and computational inference  

E-Print Network [OSTI]

and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland; E-mail: niko.beerenwinkel@bsse.ethz.ch. Abstract.— Cancer is a somatic evolutionary process characterized by the accumulation of mutations, which contribute to tumor growth, clinical... Version dated: October 7, 2014 Cancer evolution Cancer evolution: mathematical models and computational inference Niko Beerenwinkel1,2, Roland F Schwarz3, Moritz Gerstung4, Florian Markowetz5 1Department of Biosystems Science and Engineering, ETH...

Beerenwinkel, Niko; Schwarz, Roland F.; Gerstung, Moritz; Markowetz, Florian

2014-10-07T23:59:59.000Z

496

Hybrid Detection of UHECR with the Pierre Auger Observatory  

E-Print Network [OSTI]

The Pierre Auger Observatory detects ultra-high energy cosmic rays by implementing two complementary air-shower techniques. The combination of a large ground array and fluorescence detectors, known as the "hybrid" concept, means that a rich variety of measurements can be made on a single shower, providing much improved information over what is possible with either detector alone. In this paper the hybrid reconstruction approach and its performance are described.

Miguel Mostafa; for the Pierre Auger Collaboration

2006-07-31T23:59:59.000Z

497

Detection and evaluation methods for in-situ gas hydrates  

SciTech Connect (OSTI)

With the increased interest in naturally occuring hydrates, the need for improved detection and evaluation methods has also increased. In this paper, logging of hydrates is discussed and selected logs from four arctic wells are examined. A new procedure based on temperature log analysis is described. The concept of a downhole heater for use with drill stem testing is also described for testing and evaluation of hydrate intervals. 12 refs.

Goodman, M.A.; Guissani, A.P.; Alger, R.P.

1982-01-01T23:59:59.000Z

498

Perspectives on the mesenchymal origin of metastatic cancer  

E-Print Network [OSTI]

of metastasis. Nature Reviews Cancer, 9(4), 239–252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

Huysentruyt, Leanne C.; Seyfried, Thomas N.

2010-01-01T23:59:59.000Z

499

Targeting Tyrosine Kinases and Autophagy in Prostate Cancer  

E-Print Network [OSTI]

kinases and cellular signaling in prostate cancer. In: ChungW, Simons J (eds) Prostate cancer: biology, genetics and theexpres- sion in prostate cancer cells. Endocrinology 142:21–

Kung, Hsing-Jien

2011-01-01T23:59:59.000Z

500

The genomic complexity of primary human prostate cancer  

E-Print Network [OSTI]

Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

Carter, Scott Lambert