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1

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system  

SciTech Connect

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Kieper, Douglas Arthur (Seattle, WA); Majewski, Stanislaw (Morgantown, WV); Welch, Benjamin L. (Hampton, VA)

2012-07-03T23:59:59.000Z

2

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system  

DOE Patents (OSTI)

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Kieper, Douglas Arthur (Newport News, VA); Majewski, Stanislaw (Yorktown, VA); Welch, Benjamin L. (Hampton, VA)

2008-10-28T23:59:59.000Z

3

Nanomaterials for the detection of cancer-associated biomarkers  

E-Print Network (OSTI)

Prostate cancer persists as a major public health issue in the United States and remains the second leading cause of cancer death in men. Early detection and disease monitoring in prostate cancer can significantly improve ...

Mu, Chunyao Jenny

2010-01-01T23:59:59.000Z

4

Neutron Imaging Explored as Complementary Technique for Improving Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutron Imaging Explored as Complementary Technique for Improving Cancer Neutron Imaging Explored as Complementary Technique for Improving Cancer Detection August 05, 2013 Researcher Maria Cekanova analyzes the neutron radiographs of a canine breast tumor (black color in top image of monitor screen) using the software to visualize in color the various intensities of neutron transmissions through the breast tissue. ORNL and University of Tennessee collaboration now analyzing first results from neutron radiographs of cancerous tissue samples Today's range of techniques for detection of breast and other cancers include mammography, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET), and optical imaging. Each technology has advantages and disadvantages, with limitations either

5

Improving Screening Strategies for Prostate Cancer.  

E-Print Network (OSTI)

??Th is thesis describes research on screening for prostate cancer. To improve understanding of the thesis, some background information will be provided in this introduction.… (more)

Wolters, T.

2010-01-01T23:59:59.000Z

6

Modern breast cancer detection: a technological review  

Science Conference Proceedings (OSTI)

Breast cancer is a serious threat worldwide and is the number two killer of women in the United States. The key to successful management is screening and early detection. What follows is a description of the state of the art in screening and detection ...

Adam B. Nover; Shami Jagtap; Waqas Anjum; Hakki Yegingil; Wan Y. Shih; Wei-Heng Shih; Ari D. Brooks

2009-01-01T23:59:59.000Z

7

National Melanoma/Skin Cancer Detection  

E-Print Network (OSTI)

The American Academy of Dermatology (AAD) has designated May as National Melanoma/Skin Cancer Detection and Prevention Month. In 1996, an estimated 1 million cases of skin cancer will be diagnosed, of which approximately 95 % will be squamous cell or basal cell carcinomas (1). Although the incidence of melanoma is lower than those of squamous cell and basal cell carcinomas, the case-fatality rate is highest for persons with melanoma. During 1973–1992, mortality from melanoma increased 34%—the third highest increase of all cancers (2). CDC, in collaboration with the AAD, has initiated the National Skin Cancer Prevention Education Program (NSCPEP) to increase public awareness about skin cancer and to help reduce the occurrence of and deaths associated with skin cancer. Goals of this program are to develop and disseminate educational messages for children, their parents, and other caregivers; develop guidelines for school curricula; evaluate the utility and value of the ultraviolet (UV) index; and develop educational messages for health-care providers. Additional information about this month and the NSCPEP is available from

Among Children; Young Adults

1996-01-01T23:59:59.000Z

8

Automatic Tornado Prediction with an Improved Mesocyclone-Detection Algorithm  

Science Conference Proceedings (OSTI)

A new and improved algorithm for automatic mesocyclone detection is presented and tested on 23 mesocyclonic storms. A small false-alarm rate (4%) and high probability of detection (83%) are achieved for mesocyclone classification. A unique ...

Paul R. Desrochers; Ralph J. Donaldson Jr.

1992-06-01T23:59:59.000Z

9

Reducing emissions to improve nuclear test detection | National...  

National Nuclear Security Administration (NNSA)

Reducing emissions to improve nuclear test detection | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear...

10

Narrow focus ultra-wideband antenna for breast cancer detection  

Science Conference Proceedings (OSTI)

A narrow focus ultra-wideband dielectric-filled antenna has been designed for the purpose of near-field breast cancer detection without the use of coupling media. Instead of immersing the antenna in a lossy liquid coupling medium, direct matching of ... Keywords: antenna feeds, antennas, breast cancer detection, directional, radar-based imaging, ultra-wide band

Daniel M. Hailu; Safieddin Safavi-Naeini

2009-01-01T23:59:59.000Z

11

Markers Combined Inhibin and CA125 Assays in the Detection of Ovarian Cancer  

E-Print Network (OSTI)

Background: The reproductive hormone inhibin has been used as a diagnostic marker of ovarian mucinous and granulosa cell cancers. The aims of this study were to develop a new inhibin immunofluorometric assay (?C IFMA) to replace an inhibin RIA as a diagnostic marker of these ovarian cancers and to assess whether the ?C IFMA in combination with CA125, which detects serous cancers, leads to an improved biochemical diagnosis of all ovarian cancers. Methods: Serum inhibin concentrations were determined in healthy postmenopausal women (n ? 165) and women with ovarian cancers (n ? 154), using an inhibin RIA and an ?C IFMA, which detects inhibin forms containing the ?C subunit as well as the free ?C subunit. Results: The ?C IFMA gave a similar or better discrimination of mucinous (90 % vs 71%) and granulosa cell (100 % vs 100%) cancers compared with the inhibin RIA. Combination of CA125 and ?C IFMA values by canonical variate analysis or by multiROC analysis showed that the percentage of all ovarian cancers detected was significantly increased compared with either CA125 or ?C IFMA alone. Conclusions: The ?C IFMA shows a similar or better specificity compared with the RIA, but with increased sensitivity. In combination with CA125, the ?C IFMA provides an effective dual test for the detection of the majority (90%) of ovarian cancers.

David M. Robertson; Nicholas Cahir; Henry G. Burger; Pamela Mamers; Philip I. Mccloud; Kim Pettersson; Michael Mcguckin

1998-01-01T23:59:59.000Z

12

Former Worker Program - Early Lung Cancer Detection Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Former Worker Program (FWP) Former Worker Program (FWP) Home Covered Sites/Populations › Construction Worker Screening Projects › Production Worker Screening Projects › Supplemental Screening Program › Beryllium Vendor Screening Program Upcoming Events Program Implementation Outreach Medical Screening - Conventional Medical Screening - Early Lung Cancer Detection Communicating Results Protecting Participant Information Sharing De-identified Data Chronic Beryllium Disease Awareness Joint Outreach Task Group (JOTG) Worker Testimonials Contact Us FWP Scientific Publications FWP Documents Related Links Office of Health and Safety Home Page HSS Logo Early Lung Cancer Detection Program Former Worker Medical Screening Program (FWP) Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer. Through the FWP, DOE initiated the Early Lung Cancer Detection (ELCD) program using low-dose helical CT scans to detect lung cancers at an earlier, more treatable stage. Lung cancer results in about 160,000 deaths in the U.S. every year. The most common causes of lung cancer are long-term exposures to tobacco smoke and residential radon emissions, but occupational hazards, such as asbestos and ionizing radiation, also cause or contribute to the disease.

13

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents (OSTI)

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

14

Improved ?-? Coincidence Detector For Radioxenon Detection  

Science Conference Proceedings (OSTI)

The Automated Radio-xenon Analyzer/Sampler (ARSA), built by Pacific Northwest National Laboratory (PNNL), can collect and detect several radioxenon isotopes. ARSA is very sensitive to 133Xe, 131mXe, 133mXe and 135Xe due to the compact high efficiency ?-? coincidence detector it uses. For this reason it is an excellent treaty monitoring and environmental sampling device. Although the system is shown to be both robust and reliable, based on several field tests, it is also complex due to a detailed photomultiplier tube gain matching regime. This complexity is a problem from a maintenance and quality assurance/quality control (QA/QC) standpoint. To reduce these issues a simplified ??? coincident detector has been developed. A comparison of three different well detectors has been completed. In addition, a new plastic scintillator gas cell was constructed. The new simplified detector system has been demonstrated to equal or better performance compared with the original ARSA design in spectral resolution and efficiency and significantly easier to setup and calibrate.

Cooper, Matthew W.; Carman, April J.; Hayes, James C.; Heimbigner, Tom R.; Hubbard, Charles W.; Litke, Kevin E.; McIntyre, Justin I.; Morris, Scott J.; Ripplinger, Michael D.; Suarez, Reynold

2005-08-31T23:59:59.000Z

15

Reducing emissions to improve nuclear test detection | National Nuclear  

NLE Websites -- All DOE Office Websites (Extended Search)

Reducing emissions to improve nuclear test detection | National Nuclear Reducing emissions to improve nuclear test detection | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Reducing emissions to improve nuclear test detection Reducing emissions to improve nuclear test detection Posted By Office of Public Affairs In early November, medical isotope producers met with nuclear explosion

16

Improved Rooftop Detection in Aerial Images with Machine Learning  

Science Conference Proceedings (OSTI)

In this paper, we examine the use of machine learning to improve a rooftop detection process, one step in a vision system that recognizes buildings in overhead imagery. We review the problem of analyzing aerial images and describe an existing system ... Keywords: applications of learning, evaluation of algorithms, learning for computer vision, supervised learning

M. A. Maloof; P. Langley; T. O. Binford; R. Nevatia; S. Sage

2003-10-01T23:59:59.000Z

17

IMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES  

E-Print Network (OSTI)

. Analysis over consumers historical kWh load profile data from Uruguayan Elec- tric Company (UTE) showsIMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES Mat´ias Di Martino, Federico, jmolinelli}@gmail.com Keywords: Electricity theft, Support vector machine, Optimum path forest, Unbalance

18

Improving the Detection of Wind Features In Backscatter LIDAR Scans Using Feature Extraction.  

E-Print Network (OSTI)

??This thesis presents the results of applying image segmentation techniques to incoherent LIDAR data to improve the detection of wind features. Improving the detection and… (more)

Rotthoff, Eric

2012-01-01T23:59:59.000Z

19

Detection of human Papillomavirus 18 in cervical cancer samples using PCR-ELISA (DIAPOPS)  

E-Print Network (OSTI)

Background and Objectives: Human Papillomavirus (HPV) infection is a major risk factor for adenocarcinoma of the cervix. The high-risk types of the virus such as HPV16 and HPV18, which possess the E6 and E7 oncogenes, are responsible for approximately 50 % of all cervical cancers. A rapid, sensitive and specific test has been proposed for detection of HPV to improve cervical cancer screening programs. Objectives: The aim of this study was to develop a fast PCR-ELISA assay designated as DIAPOPS (Detection of Immobilized Amplified Products in a One Phase System)for detection of HPV16 and HPV18 types in SCC samples and Pap smears. The type specific primers and probes were designed for PCR and PCR-ELISA. The amplified products were hybridized with a specific biotin-labeled probe for HPV18 inner amplicons. The hybrids were detected with peroxidase conjugated avidin. The test was performed on the paraffin block and Pap smear samples from the cervical cancer patients, and the results of DIAPOPS were compared with conventional PCR assay. Results: The 70 samples (SCC and Pap smear samples) were collected from Imam Khomeini and Mirzakoochak Khan Hospitals in Tehran. The PCR-based method detected six HPV16 positive, three HPV18 positive and Two HPV33 positive samples. DIAPOPS results were compared with the conventional PCR results and they showed an increase in sensitivity of the DIAPOPS test. Not only all of them were confirmed by PCR-ELISA but also three samples that conventional PCR showed negative for HPV18, were demonstrated positive by the PCR-ELISA method. Conclusion: The results of the study show that modified PCR-ELISA assay is more sensitive to detect HPV types and can be used for diagnostic purposes.

Raji N; Sadeghizadeh M; Tafreshi K N; Jahanzad E

2011-01-01T23:59:59.000Z

20

Improving part based object detection by unsupervised, online boosting  

E-Print Network (OSTI)

Detection of objects of a given class is important for many applications. However it is difficult to learn a general detector with high detection rate as well as low false alarm rate. Especially, the labor needed for manually labeling a huge training sample set is usually not affordable. We propose an unsupervised, incremental learning approach based on online boosting to improve the performance on special applications of a set of general part detectors, which are learned from a small amount of labeled data and have moderate accuracy. Our oracle for unsupervised learning, which has high precision, is based on a combination of a set of shape based part detectors learned by off-line boosting. Our online boosting algorithm, which is designed for cascade structure detector, is able to adapt the simple features, the base classifiers, the cascade decision strategy, and the complexity of the cascade automatically to the special application. We integrate two noise restraining strategies in both the oracle and the online learner. The system is evaluated on two public video corpora. 1.

Bo Wu; Ram Nevatia

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

The improvement of cancer management by the application of the currently available knowledge.  

E-Print Network (OSTI)

??I have been intensively involved in the research on the application of currently available knowledge for the improvement of cancer care. This research covers the… (more)

Barton, Michael

2008-01-01T23:59:59.000Z

22

An MRI compatible manipulator for prostate cancer detection and treatment  

E-Print Network (OSTI)

Prostate cancer is the most frequently diagnosed cancer in men and the second most common cause of cancer related death in men. Prostate specific antigen (PSA) blood tests and digital rectal exams (DRE) are preliminary ...

DeVita, Lauren M

2007-01-01T23:59:59.000Z

23

Design and development of stacked patch antenna for breast cancer detection  

Science Conference Proceedings (OSTI)

Breast cancer affects many women, and early detection aids in fast and effective treatment. Mammography, which is currently the most popular method of breast screening, has some limitations, and microwave imaging offers an attractive alternative. The ... Keywords: breast cancer detection, stacked patch antenna, wide slot antenna

N. Mahalakshmi; N. R. Indira; P. Vasikaran

2011-02-01T23:59:59.000Z

24

Microwave tomography for breast cancer detection on Cell broadband engine processors  

Science Conference Proceedings (OSTI)

Microwave tomography (MT) is a safe screening modality that can be used for breast cancer detection. The technique uses the dielectric property contrasts between different breast tissues at microwave frequencies to determine the existence of abnormalities. ... Keywords: Breast cancer detection, Cell BE processor, Finite-difference time-domain (FDTD), Microwave tomography (MT)

Meilian Xu; Parimala Thulasiraman; Sima Noghanian

2012-09-01T23:59:59.000Z

25

6.21 Improving Neutron Beams for Cancer Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

the most advanced epithermal neutron source in the world for cancer treatment. Social Impact: Preliminary trials of BNCT therapy supported by the Office of Science have shown...

26

Improved Treatment of X-ray Resistant & Inoperable Cancers ...  

If the electron beam can be transported to the internal cancer without exposure to tissue, ... This figure shows a comparison of X-ray radiation ...

27

Improved Lithium-Loaded Liquid Scintillators for Neutron Detection  

A liquid scintillator with a substantially increased lithium weight was developed byORNL researchers. Scintillators are widely used for the detection ...

28

Nanowire-based Sensors Offer Improved Detection of Volatile ...  

Science Conference Proceedings (OSTI)

... Highly selective GaN-nanowire/TiO2-nanocluster hybrid sensors for detection of benzene and related environment pollutants. Nanotechnology. ...

2012-10-18T23:59:59.000Z

29

Increasing coverage to improve detection of network and host anomalies  

E-Print Network (OSTI)

For intrusion detection, the LERAD algorithm learns a succinct set of comprehensible rules for detecting anomalies, which could be novel attacks. LERAD validates the learned rules on a separate held-out validation set and removes rules that cause false alarms. However, removing rules with possible high coverage can lead to missed detections. We propose three techniques for increasing coverage- Weighting, Replacement and Hybrid. Weighting retains previously pruned rules and associate weights to them. Replacement, on the other hand, substitutes pruned rules with other candidate rules to ensure high coverage. We also present a Hybrid approach that selects between the two techniques based on training data coverage. Empirical results from seven data sets indicate that, for LERAD, increasing coverage by Weighting, Replacement and Hybrid detects more attacks than Pruning with minimal computational overhead.

Gaurav Tandon; Philip K. Chan

2007-01-01T23:59:59.000Z

30

Low-Dose Spiral CT Scans for Early Lung Cancer Detection | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-Dose Spiral CT Scans for Early Lung Cancer Detection Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999). A low-dose spiral chest CT differs from a full-dose conventional chest CT scan primarily in the amount of radiation emitted during CT scans. Chest CT, in general, requires less radiation exposure than other CT procedures because the air-filled tissues of the lungs are not as dense as the tissues of other organs (i.e., less x-ray radiation is needed to penetrate the lung). Radiation dose can be further reduced with lung cancer screening due to the

31

Dynamic fluorescence imaging with molecular agents for cancer detection  

E-Print Network (OSTI)

Non-invasive dynamic optical imaging of small animals requires the development of a novel fluorescence imaging modality. Herein, fluorescence imaging is demonstrated with sub-second camera integration times using agents specifically targeted to disease markers, enabling rapid detection of cancerous regions. The continuous-wave fluorescence imaging acquires data with an intensified or an electronmultiplying charge-coupled device. The work presented in this dissertation (i) assessed dose-dependent uptake using dynamic fluorescence imaging and pharmacokinetic (PK) models, (ii) evaluated disease marker availability in two different xenograft tumors, (iii) compared the impact of autofluorescence in fluorescence imaging of near-infrared (NIR) vs. red light excitable fluorescent contrast agents, (iv) demonstrated dual-wavelength fluorescence imaging of angiogenic vessels and lymphatics associated with a xenograft tumor model, and (v) examined dynamic multi-wavelength, whole-body fluorescence imaging with two different fluorescent contrast agents. PK analysis showed that the uptake of Cy5.5-c(KRGDf) in xenograft tumor regions linearly increased with doses of Cy5.5-c(KRGDf) up to 1.5 nmol/mouse. Above 1.5 nmol/mouse, the uptake did not increase with doses, suggesting receptor saturation. Target to background ratio (TBR) and PK analysis for two different tumor cell lines showed that while Kaposi’s sarcoma (KS1767) exhibited early and rapid uptake of Cy5.5-c(KRGDf), human melanoma tumors (M21) had non-significant TBR differences and early uptake rates similar to the contralateral normal tissue regions. The differences may be due to different compartment location of the target. A comparison of fluorescence imaging with NIR vs. red light excitable fluorescent dyes demonstrates that NIR dyes are associated with less background signal, enabling rapid tumor detection. In contrast, animals injected with red light excitable fluorescent dyes showed high autofluorescence. Dual-wavelength fluorescence images were acquired using a targeted 111In- DTPA-K(IRDye800)-c(KRGDf) to selectively detect tumor angiogenesis and an untargeted Cy5.5 to image lymphatics. After acquiring the experimental data, fluorescence image-guided surgery was performed. Dynamic, multi-wavelength fluorescence imaging was accomplished using a liquid crystal tunable filter (LCTF). Excitation light was used for reflectance images with a LCTF transmitting a shorter wavelength than the peak in the excitation light spectrum. Therefore, images can be dynamically acquired alternating frame by frame between emission and excitation light, which should enable image-guided surgery.

Kwon, Sun Kuk

2006-12-01T23:59:59.000Z

32

Method for improving the limit of detection in a data signal  

DOE Patents (OSTI)

A method for improving the limit of detection for a data set in which experimental noise is uncorrelated along a given abscissa and an analytical signal is correlated to the abscissa, the steps comprising collecting the data set, converting the data set into a data signal including an analytical portion and the experimental noise portion, designating and adjusting a baseline of the data signal to center the experimental noise numerically about a zero reference, and integrating the data signal preserving the corresponding information for each point of the data signal. The steps of the method produce an enhanced integrated data signal which improves the limit of detection of the data signal.

Synovec, Robert E. (Ames, IA); Yueng, Edward S. (Ames, IA)

1989-10-17T23:59:59.000Z

33

Detection of Ionizing Radiation by Plasma-Panel Sensors: Cosmic Muons, Ion Beams, and Cancer Therapy  

Science Conference Proceedings (OSTI)

The plasma panel sensor is an ionizing photon and particle radiation detector derived from PDP technology with high gain and nanosecond response. Experimental results in detecting cosmic ray muons and beta particles from radioactive sources are described along with applications including high energy and nuclear physics, homeland security and cancer therapeutics.

Friedman, Dr. Peter S. [Integrated Sensors, LLC; Ferretti, Claudio [University of Michigan; Ball, Robert [University of Michigan; Beene, James R [ORNL; Ben Moshe, M. [Tel Aviv University; Benhammou, Yan [Tel Aviv University; Chapman, J. Wehrley [University of Michigan; Levin, Daniel S. [University of Michigan; Silver, Yiftah [Tel Aviv University; Weaverdyck, Curtis [University of Michigan; Zhou, Bing [University of Michigan; Etzion, E [Tel Aviv University; Moshe, M. [Tel Aviv University; Bentefour, E [Ion Beam Applications

2012-01-01T23:59:59.000Z

34

Occurrence of Breast Cancer After Chest Wall Irradiation for Pediatric Cancer, as Detected by a Multimodal Screening Program  

Science Conference Proceedings (OSTI)

Purpose: To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program. Patients and Methods: We identified 86 patients who had received chest wall radiation therapy for pediatric cancer. Clinical breast examination (CBE), ultrasound (US), and mammography (MX) were performed yearly. Magnetic resonance imaging (MRI) was added as of October 2007. We calculated the risk of developing BC by radiation therapy dose, patient age, and menarche before or after primary treatment. Results: Eleven women developed a BC from July 2002-February 2010. The sensitivity of the screening methods was 36% for CBE, 73% for MX, 55% for US, and 100% for MRI; the specificity was 91%, 99%, 95%, and 80% for CBE, MX, US, and MRI, respectively. The annual BC detection rate was 2.9%. The median age at BC diagnosis was 33 years. Although age had no influence, menarche before as opposed to after radiation therapy correlated significantly with BC (P=.027): the annual BC detection rate in the former subgroup was 5.3%. Conclusions: Mammography proved more sensitive and specific in our cohort of young women than CBE or US. Magnetic resonance imaging proved 100% sensitive (but this preliminary finding needs to be confirmed). Our cohort of patients carries a 10-fold BC risk at an age more than 20 years younger than in the general population.

Terenziani, Monica [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Casalini, Patrizia [Molecular Biology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Molecular Biology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Scaperrotta, Gianfranco; Gandola, Lorenza; Trecate, Giovanna [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Catania, Serena; Cefalo, Graziella [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Conti, Alberto [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Massimino, Maura; Meazza, Cristina; Podda, Marta; Spreafico, Filippo [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Suman, Laura [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Gennaro, Massimiliano, E-mail: gennaromassimiliano@istitutotumori.mi.it [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)] [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)

2013-01-01T23:59:59.000Z

35

Investigation of the principle of flame rectification in order to improve detection of the propane flame in absorption refrigerators.  

E-Print Network (OSTI)

?? Electrical properties of a propane flame was investigated to improve detection of the flame in absorption refrigerators. The principle of flame rectification, which uses… (more)

Möllberg, Andreas

2005-01-01T23:59:59.000Z

36

Method for improving the limit of detection in a data signal  

DOE Patents (OSTI)

Disclosed is a method for improving the limit of detection for a data set in which experimental noise is uncorrelated along a given abscissa and an analytical signal is correlated to the abscissa, the steps comprising collecting the data set, converting the data set into a data signal including an analytical portion and the experimental noise portion, designating and adjusting a baseline of the data signal to center the experimental noise numerically about a zero reference, and integrating the data signal preserving the corresponding information for each point of the data signal. The steps of the method produce an enhanced integrated data signal which improves the limit of detection of the data signal. 8 figs.

Synovec, R.E.; Yueng, E.S.

1989-10-17T23:59:59.000Z

37

Improved visual detection of moving objects in astronomical images using color intensity projections with hue cycling  

E-Print Network (OSTI)

While fully automated methods for detecting faint moving objects in astronomical images - such as Kuiper belt objects (KBOs) - are constantly improving, visual detection still has a role to play especially when the fixed background is cluttered with stars. Color intensity projections (CIPs) using hue cycling - which combines a sequence of greyscale images into a single color image - aids in the visual detection of moving objects by highlighting them using color in an intuitive way. To demonstrate the usefulness of CIPs in detecting faint moving objects a sequence of 16 images from the SuprimeCam camera of the Subaru telescope were combined into a CIPs image. As well has making even faint moving objects easier to visually detect against a cluttered background, CCD artefacts were also more easily recognisable. The new Hyper SuprimeCam for the Subaru telescope - which will allow many short exposure images to be acquired with little dead time between images - should provide ideal data for use with the CIPs algori...

Cover, Keith S

2012-01-01T23:59:59.000Z

38

Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules  

E-Print Network (OSTI)

RESEARCH ARTICLE Open Access Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules Andrew E Teschendorff1,8*, Sergio Gomez2, Alex Arenas2,3,4, Dorraya El-Ashry5, Marcus... that consistency and trends in mRNA expres- sion levels of interacting proteins may be used to infer pathway activity [6-8]. In this work we refer to both the perturbation signatures and molecular interaction mod- els as “model signatures”. These same studies...

Teschendorff, Andrew E; Gomez, Sergio; Arenas, Alex; El-Ashry, Dorraya; Schmidt, Marcus; Gehrmann, Mathias; Caldas, Carlos

2010-11-04T23:59:59.000Z

39

Early Detection of Melanoma and other Cancers in Residents of Nevada  

SciTech Connect

The overall goal of this project was to develop simple and inexpensive tests to screen for the presence of early stage cancer in the residents of Nevada with a particular emphasis on the membership of the Hotel Employee Restaurant Employee International Union (HEREIU) in Las Vegas. Our specific goals were: 1) to develop a clinical database of individuals with cancer and to create a biological specimen Collection and Storage Systems (the NVCI bio-bank); 2) to initiate screening of individuals for proteomic markers indicating susceptibility to or the presence of specific cancers, e.g. breast, ovarian, prostate and bladder. In addition, we proposed the implementation of novel digital imaging technologies to detect melanoma; 3) to genotype blood samples from individuals who consent to participate in IRB approved research studies using a high throughput single nucleotide polymorphisms (SNP) method based on optical thin-film biosensor chip technology; and 4) to conduct biostatistical analysis of clinical, demographic, genetic, proteomic and digital imaging data to stratify the population cohort into relative risk groups for cancers that are prevalent in Nevada.

David Ward, PhD and Nicholas Vogelzang, MD

2006-10-30T23:59:59.000Z

40

The improvement of breast cancer prognosis accuracy from integrated gene expression and clinical data  

Science Conference Proceedings (OSTI)

Predicting the accurate prognosis of breast cancer from high throughput microarray data is often a challenging task. Although many statistical methods and machine learning techniques were applied to diagnose the prognosis outcome of breast cancer, they ... Keywords: Breast cancer prognosis, Cancer classification, Clinical data, Gene expression, Gene selection, Genetic algorithm, Support vector machine

Austin H. Chen; Chenyin Yang

2012-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer  

Science Conference Proceedings (OSTI)

We previously demonstrated the efficacy of BNCT mediated by boronophenylalanine (BPA) to treat tumors in a hamster cheek pouch model of oral cancer with no normal tissue radiotoxicity and moderate, albeit reversible, mucositis in precancerous tissue around treated tumors. It is known that boron targeting of the largest possible proportion of tumor cells contributes to the success of BNCT and that tumor blood vessel normalization improves drug delivery to the tumor. Within this context, the aim of the present study was to evaluate the effect of blood vessel normalization on the therapeutic efficacy and potential radiotoxicity of BNCT in the hamster cheek pouch model of oral cancer.

D. W. Nigg

2012-01-01T23:59:59.000Z

42

Improving the Detection and Tracking of Tropical Cyclones in Atmospheric General Circulation Models  

Science Conference Proceedings (OSTI)

Dynamical seasonal forecasts of tropical storm frequency require robust and efficient algorithms for detection and tracking of tropical storms in atmospheric general circulation models (AGCMs). Tropical storms are generally detected when dynamic ...

Suzana J. Camargo; Stephen E. Zebiak

2002-12-01T23:59:59.000Z

43

An improved MRF-based change detection approach for multitemporal remote sensing imagery  

Science Conference Proceedings (OSTI)

In the task of multitemporal remote sensing image change detection, conventional Markov random field (MRF) based approaches consider contextual information between neighboring pixels to obtain the change map. However, these approaches often get erroneous ... Keywords: Adaptive weight, Change detection, Difference image, Line process, Markov random field (MRF)

Yin Chen; Zhiguo Cao

2013-01-01T23:59:59.000Z

44

Fusing multiple image transformations and a thermal sensor with kinect to improve person detection ability  

Science Conference Proceedings (OSTI)

This paper proposes a novel approach to combine data from multiple low-cost sensors to detect people in a mobile robot. Robust detection of people is a key capability required for robots working in environments with people. Several works have shown the ... Keywords: Computer vision, Data fusion, Image transformations, Machine learning

L. Susperregi, A. Arruti, E. Jauregi, B. Sierra, J. M. MartíNez-Otzeta, E. Lazkano, A. Ansuategui

2013-09-01T23:59:59.000Z

45

Improved  

NLE Websites -- All DOE Office Websites (Extended Search)

Improved Improved cache performance in Monte Carlo transport calculations using energy banding A. Siegel a , K. Smith b , K. Felker c,∗ , P . Romano b , B. Forget b , P . Beckman c a Argonne National Laboratory, Theory and Computing Sciences and Nuclear Engineering Division b Massachusetts Institute of Technology, Department of Nuclear Science and Engineering c Argonne National Laboratory, Theory and Computing Sciences Abstract We present an energy banding algorithm for Monte Carlo (MC) neutral parti- cle transport simulations which depend on large cross section lookup tables. In MC codes, read-only cross section data tables are accessed frequently, ex- hibit poor locality, and are typically much too large to fit in fast memory. Thus, performance is often limited by long latencies to RAM, or by off-node communication latencies when the data footprint is very large and must be decomposed on

46

Improved Detection of Hotspots using the AVHRR 3.7-um Channel  

Science Conference Proceedings (OSTI)

The 3.7-?m channel on-board the National Oceanic and Atmospheric Administration's (NOAA) Advanced Very High Resolution Radiometer (AVHRR) provides the unique capability to detect small, but hot, surface features. We present an image-processing ...

Thomas F. Lee; Paul M. Tag

1990-12-01T23:59:59.000Z

47

IMPLEMENTION AND TESTING OF A FAULT DETECTION SOFTWARE TOOL FOR IMPROVING CONTROL SYSTEM  

E-Print Network (OSTI)

affect the performance of the control scheme and its fault detection sensitivity. 5.2.3 Trend Logging. The process of selecting trend-logging procedures exposed several generic problems faced by building operators

Diamond, Richard

48

Fusion of state space and frequency-domain features for improved microsleep detection  

Science Conference Proceedings (OSTI)

A novel approach for Microsleep Event detection is presented. This is achieved based on multisensor electroencephalogram (EEG) and electrooculogram (EOG) measurements recorded during an overnight driving simulation task. First, using video clips of the ...

David Sommer; Mo Chen; Martin Golz; Udo Trutschel; Danilo Mandic

2005-09-01T23:59:59.000Z

49

Computational methods for analyzing and detecting genomic structural variation : applications to cancer  

E-Print Network (OSTI)

Accurate whole human genome sequencing using reversibleson, S. , 2008: Rapid genome sequencing with short universalalterations in cancer. In Genome Sequencing Technology and

Bashir, Ali

2009-01-01T23:59:59.000Z

50

Approaches for automated detection and classification of masses in mammograms  

Science Conference Proceedings (OSTI)

Breast cancer continues to be a significant public health problem in the world. Early detection is the key for improving breast cancer prognosis. Mammography has been one of the most reliable methods for early detection of breast carcinomas. However, ... Keywords: CAD, Contrast enhancement, Feature selection, Fuzzy logic, Mammogram, Mass, Wavelet

H. D. Cheng; X. J. Shi; R. Min; L. M. Hu; X. P. Cai; H. N. Du

2006-04-01T23:59:59.000Z

51

Improving Cyber-Security of Smart Grid Systems via Anomaly Detection and Linguistic Domain Knowledge  

Science Conference Proceedings (OSTI)

The planned large scale deployment of smart grid network devices will generate a large amount of information exchanged over various types of communication networks. The implementation of these critical systems will require appropriate cyber-security measures. A network anomaly detection solution is considered in this work. In common network architectures multiple communications streams are simultaneously present, making it difficult to build an anomaly detection solution for the entire system. In addition, common anomaly detection algorithms require specification of a sensitivity threshold, which inevitably leads to a tradeoff between false positives and false negatives rates. In order to alleviate these issues, this paper proposes a novel anomaly detection architecture. The designed system applies the previously developed network security cyber-sensor method to individual selected communication streams allowing for learning accurate normal network behavior models. Furthermore, the developed system dynamically adjusts the sensitivity threshold of each anomaly detection algorithm based on domain knowledge about the specific network system. It is proposed to model this domain knowledge using Interval Type-2 Fuzzy Logic rules, which linguistically describe the relationship between various features of the network communication and the possibility of a cyber attack. The proposed method was tested on experimental smart grid system demonstrating enhanced cyber-security.

Ondrej Linda; Todd Vollmer; Milos Manic

2012-08-01T23:59:59.000Z

52

An improved strategy to detect CO2 leakage for verification ofgeologic carbon sequestration  

SciTech Connect

To detect and quantify subtle surface CO2 leakage signals, we present a strategy that combines measurements of CO2 fluxes or concentrations in the near-surface environment with an algorithm that enhances temporally- and spatially-correlated leakage signals while suppressing random background noise. The algorithm consists of a filter that highlights spatial coherence in the leakage signal, and temporal stacking (averaging) that reduces noise from temporally uncorrelated background fluxes/concentrations. We assess the performance of our strategy using synthetic data sets in which the surface leakage signal is either specified directly or calculated using flow and transport simulations of leakage source geometries one might expect to be present at sequestration sites. We estimate the number of measurements required to detect a potential CO2 leakage signal of given magnitude and area. Results show that given a rigorous field-sampling program, subtle CO2 leakage may be detected using the algorithm; however, leakage of very limited spatial extent or exceedingly small magnitude may be difficult to detect with a reasonable set of monitoring resources.

Lewicki, Jennifer L.; Hilley, George E.; Oldenburg, Curtis M.

2006-05-11T23:59:59.000Z

53

A Daytime Complement to the Reverse Absorption Technique for Improved Automated Detection of Volcanic Ash  

Science Conference Proceedings (OSTI)

An automated volcanic cloud detection algorithm that utilizes four spectral channels (0.65, 3.75, 11, and 12 ?m) that are common among several satellite-based instruments is presented. The new algorithm is physically based and globally applicable ...

Michael J. Pavolonis; Wayne F. Feltz; Andrew K. Heidinger; Gregory M. Gallina

2006-11-01T23:59:59.000Z

54

Development of OLED panel defect detection system through improved otsu algorithm  

Science Conference Proceedings (OSTI)

OLED (Organic light-emitting) displays have been called the next generation of display devices for their unique properties: colorful images, large viewing angle, light weight and power efficiency. Complex manufacture processing makes the screen have ... Keywords: OLED panel, Otsu method, defect detection, image segmentation, subtraction operation

Jian Gao; Zhiliang Wang; Yanyun Liu; Chuanxia Jian; Xin Chen

2012-10-01T23:59:59.000Z

55

An Improved Video Mosaic Block Detection Method Considering the Boundary of Macroblock  

Science Conference Proceedings (OSTI)

This passage proposes a new method to detect mosaic not only using the Y (luminance) component in YUV color space of videos, but also using the U (chrominance) and V component. The mosaic effect is measured by the boundary pixel difference from the neighbor ... Keywords: mosaic, video, TV, macroblock

Quanwu Dong; Tong Zhou; Jianguo Xiao

2012-07-01T23:59:59.000Z

56

Evaluation of Breast Cancer Susceptibility Using Improved Genetic Algorithms to Generate Genotype SNP Barcodes  

Science Conference Proceedings (OSTI)

Genetic association is a challenging task for the identification and characterization of genes that increase the susceptibility to common complex multifactorial diseases. To fully execute genetic studies of complex diseases, modern geneticists face the ... Keywords: breast cancer,Single nucleotide polymorphism,SNP-SNP interactions,genetic algorithm

Cheng-Hong Yang; Yu-Da Lin; Li-Yeh Chaung; Hsueh-Wei Chang

2013-03-01T23:59:59.000Z

57

A Novel Technique for Improving Hardware Trojan Detection and Reducing Trojan Activation Time  

E-Print Network (OSTI)

transitions in the circuit would be attributed to state bits and it is expected that activities converge or more transitions inside Trojan circuit so that it improves the effectiveness of transient power of nets with low transition rate, we will eliminate hard-to-activate sites in a design. This would result

Plusquellic, James

58

Method for detecting cancer in a single cell using mitochondrial correlation microscopy  

SciTech Connect

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L. (Albuquerque, NM)

2012-03-06T23:59:59.000Z

59

Method for improved selectivity in photo-activation and detection of molecular diagnostic agents  

DOE Patents (OSTI)

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

Wachter, Eric A. (Oak Ridge, TN); Fisher, Walter G. (Knoxville, TN); Dees, H. Craig (Knoxville, TN)

1998-01-01T23:59:59.000Z

60

Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents  

DOE Patents (OSTI)

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

Wachter, Eric A. (Oak Ridge, TN); Fisher, Walter G. (Knoxville, TN); Dees, H. Craig (Knoxville, TN)

2008-03-18T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Method for improved selectivity in photo-activation and detection of molecular diagnostic agents  

DOE Patents (OSTI)

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.

Wachter, E.A.; Fisher, W.G.; Dees, H.C.

1998-11-10T23:59:59.000Z

62

Effectiveness of a clinical intervention in improving pain control in outpatients with cancer treated by radiation therapy  

SciTech Connect

Purpose: To determine the effectiveness of a multicomponent clinical intervention to reduce pain in outpatients with cancer. Methods and Materials: Sixty-four patients were randomly assigned to receive either a clinical intervention including an information session, the use of a pain diary, and the possibility to contact a physician to adjust the pain medication, or the usual treatment of pain by the staff radiation oncologist. All patients reported their average and worst pain levels at baseline and 2 and 3 weeks after the start of the intervention. Results: The study groups were similar with respect to their baseline characteristics and pain levels at randomization. After 3 weeks, the average and worst pain experienced by patients randomized to the clinical intervention group was significantly inferior to the average pain experienced by patients in the control group (2.9/10 vs. 4.4/10 and 4.2/10 vs. 5.5/10, respectively). Results showed that the experimental group patients decreased their pain levels more than the control group patients did over time. Conclusion: An intervention including patient education, a pain diary, and defining a procedure for therapeutic adjustments can be effective to improve pain relief in outpatients with cancer.

Vallieres, Isabelle [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-Hotel-Dieu de Quebec, Quebec City (Canada)]. E-mail: isabelle.vallieres@mail.chuq.qc.ca; Aubin, Michele [Department of Family Medicine, Laval Hospital, Quebec City, Quebec (Canada); Blondeau, Lucie [Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec-Hotel-Dieu de Quebec, Quebec City (Canada); Simard, Serge [Research Centre of Laval Hospital, Laval University, Sainte-Foy, Quebec (Canada); Giguere, Anik [Palliative Care Research Team, Laval University, Quebec City, Quebec (Canada)

2006-09-01T23:59:59.000Z

63

Improved Dosimetric and Clinical Outcomes With Intensity-Modulated Radiotherapy for Head-and-Neck Cancer of Unknown Primary Origin  

SciTech Connect

Purpose: To compare differences in dosimetric, clinical, and quality-of-life endpoints among a cohort of patients treated by intensity-modulated radiotherapy (IMRT) and conventional radiotherapy (CRT) for head-and-neck cancer of unknown primary origin. Methods and Materials: The medical records of 51 patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Twenty-four patients (47%) were treated using CRT, and 27 (53%) were treated using IMRT. The proportions of patients receiving concurrent chemotherapy were 54% and 63%, respectively. Results: The 2-year estimates of overall survival, local-regional control, and disease-specific survival for the entire patient population were 86%, 89%, and84%, respectively. There were no significant differences in any of these endpoints with respect to radiation therapy technique (p > 0.05 for all). Dosimetric analysis revealed that the use of IMRT resulted in significant improvements with respect to mean dose and V30 to the contralateral (spared) parotid gland. In addition, mean doses to the ipsilateral inner and middle ear structures were significantly reduced with IMRT (p < 0.05 for all). The incidence of severe xerostomia in the late setting was 58% and 11% among patients treated by CRT and IMRT, respectively (p < 0.001). The percentages of patients who were G-tube dependent at 6 months after treatment were 42% and 11%, respectively (p < 0.001). Conclusions: IMRT results in significant improvements in the therapeutic ratio among patients treated by radiation therapy for head-and-neck cancer of unknown primary origin.

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.ed [Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Li Baoqing [Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Farwell, D. Gregory [Department of Otolaryngology-Head and Neck Surgery, University of California Davis School of Medicine, Sacramento, CA (United States); Marsano, Joseph; Vijayakumar, Srinivasan; Purdy, James A. [Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States)

2011-03-01T23:59:59.000Z

64

Non-invasive detection of oral cancer using reflectance and fluorescence spectroscopy  

E-Print Network (OSTI)

In vivo reflectance and fluorescence spectra were collected from patients with oral lesions, as well as healthy volunteers, in order to evaluate the potential of spectroscopy to serve as a non-invasive tool for the detection ...

McGee, Sasha Alanda

2008-01-01T23:59:59.000Z

65

Using a Reduced Spot Size for Intensity-Modulated Proton Therapy Potentially Improves Salivary Gland-Sparing in Oropharyngeal Cancer  

Science Conference Proceedings (OSTI)

Purpose: To investigate whether intensity-modulated proton therapy with a reduced spot size (rsIMPT) could further reduce the parotid and submandibular gland dose compared with previously calculated IMPT plans with a larger spot size. In addition, it was investigated whether the obtained dose reductions would theoretically translate into a reduction of normal tissue complication probabilities (NTCPs). Methods: Ten patients with N0 oropharyngeal cancer were included in a comparative treatment planning study. Both IMPT plans delivered simultaneously 70 Gy to the boost planning target volume (PTV) and 54 Gy to the elective nodal PTV. IMPT and rsIMPT used identical three-field beam arrangements. In the IMPT plans, the parotid and submandibular salivary glands were spared as much as possible. rsIMPT plans used identical dose-volume objectives for the parotid glands as those used by the IMPT plans, whereas the objectives for the submandibular glands were tightened further. NTCPs were calculated for salivary dysfunction and xerostomia. Results: Target coverage was similar for both IMPT techniques, whereas rsIMPT clearly improved target conformity. The mean doses in the parotid glands and submandibular glands were significantly lower for three-field rsIMPT (14.7 Gy and 46.9 Gy, respectively) than for three-field IMPT (16.8 Gy and 54.6 Gy, respectively). Hence, rsIMPT significantly reduced the NTCP of patient-rated xerostomia and parotid and contralateral submandibular salivary flow dysfunction (27%, 17%, and 43% respectively) compared with IMPT (39%, 20%, and 79%, respectively). In addition, mean dose values in the sublingual glands, the soft palate and oral cavity were also decreased. Obtained dose and NTCP reductions varied per patient. Conclusions: rsIMPT improved sparing of the salivary glands and reduced NTCP for xerostomia and parotid and submandibular salivary dysfunction, while maintaining similar target coverage results. It is expected that rsIMPT improves quality of life during and after radiotherapy treatment.

Water, Tara A. van de, E-mail: t.a.van.de.water@rt.umcg.nl [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Lomax, Antony J. [Centre for Proton Therapy, Paul Scherrer Institute, Villigen-PSI (Switzerland); Bijl, Hendrik P.; Schilstra, Cornelis [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Hug, Eugen B. [Centre for Proton Therapy, Paul Scherrer Institute, Villigen-PSI (Switzerland); Langendijk, Johannes A. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

2012-02-01T23:59:59.000Z

66

A novel cognitive interpretation of breast cancer thermography with complementary learning fuzzy neural memory structure  

Science Conference Proceedings (OSTI)

Early detection of breast cancer is the key to improve survival rate. Thermogram is a promising front-line screening tool as it is able to warn women of breast cancer up to 10 years in advance. However, analysis and interpretation of thermogram are heavily ... Keywords: Breast cancer diagnosis, Complementary learning, FALCON-AART, Fuzzy adaptive learning control network fuzzy neural network, Thermogram

T. Z. Tan; C. Quek; G. S. Ng; E. Y. K. Ng

2007-10-01T23:59:59.000Z

67

Impact of computed tomography and {sup 18}F-deoxyglucose coincidence detection emission tomography image fusion for optimization of conformal radiotherapy in non-small-cell lung cancer  

SciTech Connect

Purpose: To report a retrospective study concerning the impact of fused {sup 18}F-fluoro-deoxy-D-glucose (FDG)-hybrid positron emission tomography (PET) and CT images on three-dimensional conformal radiotherapy planning for patients with non-small-cell lung cancer. Methods and Materials: A total of 101 patients consecutively treated for Stage I-III non-small-cell lung cancer were studied. Each patient underwent CT and FDG-hybrid PET for simulation treatment in the same treatment position. Images were coregistered using five fiducial markers. Target volume delineation was initially performed on the CT images, and the corresponding FDG-PET data were subsequently used as an overlay to the CT data to define the target volume. Results: {sup 18}F-fluoro-deoxy-D-glucose-PET identified previously undetected distant metastatic disease in 8 patients, making them ineligible for curative conformal radiotherapy (1 patient presented with some positive uptake corresponding to concomitant pulmonary tuberculosis). Another patient was ineligible for curative treatment because the fused PET-CT images demonstrated excessively extensive intrathoracic disease. The gross tumor volume (GTV) was decreased by CT-PET image fusion in 21 patients (23%) and was increased in 24 patients (26%). The GTV reduction was {>=}25% in 7 patients because CT-PET image fusion reduced the pulmonary GTV in 6 patients (3 patients with atelectasis) and the mediastinal nodal GTV in 1 patient. The GTV increase was {>=}25% in 14 patients owing to an increase in the pulmonary GTV in 11 patients (4 patients with atelectasis) and detection of occult mediastinal lymph node involvement in 3 patients. Of 81 patients receiving a total dose of {>=}60 Gy at the International Commission on Radiation Units and Measurements point, after CT-PET image fusion, the percentage of total lung volume receiving >20 Gy increased in 15 cases and decreased in 22. The percentage of total heart volume receiving >36 Gy increased in 8 patients and decreased in 14. The spinal cord volume receiving at least 45 Gy (2 patients) decreased. Multivariate analysis showed that tumor with atelectasis was the single independent factor that resulted in a significant effect on the modification of the size of the GTV by FDG-PET: tumor with atelectasis (with vs. without atelectasis, p = 0.0001). Conclusion: The results of our study have confirmed that integrated hybrid PET/CT in the treatment position and coregistered images have an impact on treatment planning and management of non-small-cell lung cancer. However, FDG images using dedicated PET scanners and respiration-gated acquisition protocols could improve the PET-CT image coregistration. Furthermore, the impact on treatment outcome remains to be demonstrated.

Deniaud-Alexandre, Elisabeth [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); Touboul, Emmanuel [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France)]. E-mail: emmanuel.touboul@tnn.aphp.fr; Lerouge, Delphine [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); Grahek, Dany [Department of Nuclear Medicine, Tenon Hospital A.P.-H.P., Paris (France); Foulquier, Jean-Noel [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); Petegnief, Yolande [Department of Nuclear Medicine, Tenon Hospital A.P.-H.P., Paris (France); Gres, Benoit [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); El Balaa, Hanna [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); Keraudy, Katia [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Paris (France); Kerrou, Kaldoun [Department of Nuclear Medicine, Tenon Hospital A.P.-H.P., Paris (France); Montravers, Francoise [Department of Nuclear Medicine, Tenon Hospital A.P.-H.P., Paris (France); Milleron, Bernard [Department of Respiratory Medicine, Tenon Hospital A.P.-H.P., Paris (France); Lebeau, Bernard [Department of Respiratory Medicine, Saint-Antoine Hospital A.P.-H.P., Paris (France) and Cancerest, Paris VI University, Paris (France); Talbot, Jean-Noel [Department of Nuclear Medicine, Tenon Hospital A.P.-H.P., Paris (France)

2005-12-01T23:59:59.000Z

68

Extending the Sensitivity to the Detection of WIMP Dark Matter with an Improved Understanding of the Limiting Neutron Backgrounds  

SciTech Connect

The Cryogenic Dark Matter Search (CDMS) uses position-sensitive Germanium and Silicon crystals in the direct detection of Weakly Interacting Massive Particles (WIMPs) believed to constitute most of the dark matter in the Universe. WIMP interactions with matter being rare, identifying and eliminating known backgrounds is critical for detection. Event-by-event discrimination by the detectors rejects the predominant gamma and beta backgrounds while Monte Carlo simulations help estimate, and subtract, the contribution from the neutrons. This thesis describes the effort to understand neutron backgrounds as seen in the two stages of the CDMS search for WIMPs. The first stage of the experiment was at a shallow site at the Stanford Underground Facility where the limiting background came from high-energy neutrons produced by cosmic-ray muon interactions in the rock surrounding the cavern. Simulations of this background helped inform the analysis of data from an experimental run at this site and served as input for the background reduction techniques necessary to set new exclusion limits on the WIMP-nucleon cross-section, excluding new parameter space for WIMPs of masses 8-20 GeV/c{sup 2}. This thesis considers the simulation methods used as well as how various event populations in the data served as checks on the simulations to allow them to be used in the interpretation of the WIMP-search data. The studies also confirmed the presence of a limiting neutron background at the shallow site, necessitating the move to the 713-meter deep Soudan Underground Facility. Similar computer-based studies helped quantify the neutron background seen at the deeper site and informed the analysis of the data emerging from the first physics run of the experiment at Soudan. In conjunction with the WIMP-search and calibration data, the simulations confirmed that increased depth considerably reduced the neutron backgrounds seen, greatly improving the sensitivity to WIMP detection. The data run set an upper limit of 4 x 10{sup -43} on the WIMP-nucleon cross section for a WIMP mass of 60 GeV/c{sup 2} . Upper limits to the rate of background neutrons have also been determined.

Kamat, Sharmila; /Case Western Reserve U.

2005-01-01T23:59:59.000Z

69

Study on New Methods of Improving the Accuracy of Leak Detection and Location of Natural Gas Pipeline  

Science Conference Proceedings (OSTI)

As negative pressure wave is applied to leak detection and location of natural gas pipeline, the key is how to realize accurate measurement of propagation velocity of pressure wave and time difference. However, there exists problem of lower accuracy ... Keywords: natural gas pipeline, leak detection and location, negative pressure wave, wavelet transform, singularity detection

Shuqing Zhang; Tianye Gao; Hong Xu; Guangpu Hao; Zhongdong Wang

2009-04-01T23:59:59.000Z

70

Ultrafast nanolaser device for detecting cancer in a single live cell.  

Science Conference Proceedings (OSTI)

Emerging BioMicroNanotechnologies have the potential to provide accurate, realtime, high throughput screening of live tumor cells without invasive chemical reagents when coupled with ultrafast laser methods. These optically based methods are critical to advancing early detection, diagnosis, and treatment of disease. The first year goals of this project are to develop a laser-based imaging system integrated with an in- vitro, live-cell, micro-culture to study mammalian cells under controlled conditions. In the second year, the system will be used to elucidate the morphology and distribution of mitochondria in the normal cell respiration state and in the disease state for normal and disease states of the cell. In this work we designed and built an in-vitro, live-cell culture microsystem to study mammalian cells under controlled conditions of pH, temp, CO2, Ox, humidity, on engineered material surfaces. We demonstrated viability of cell culture in the microsystem by showing that cells retain healthy growth rates, exhibit normal morphology, and grow to confluence without blebbing or other adverse influences of the material surfaces. We also demonstrated the feasibility of integrating the culture microsystem with laser-imaging and performed nanolaser flow spectrocytometry to carry out analysis of the cells isolated mitochondria.

Gourley, Paul Lee; McDonald, Anthony Eugene

2007-11-01T23:59:59.000Z

71

A Prospective Randomized Trial to Study the Impact of Pretreatment FDG-PET for Cervical Cancer Patients With MRI-Detected Positive Pelvic but Negative Para-Aortic Lymphadenopathy  

Science Conference Proceedings (OSTI)

Purpose: This prospective randomized study was undertaken to determine the possible impact of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) on extrapelvic metastasis detection, radiation field design, and survival outcome for cervical cancer patients with enlarged pelvic nodes on MRI image. Methods and Materials: Inclusion criteria were patients with newly diagnosed Stage I-IVA cervical cancer and with positive pelvic but negative para-aortic lymph nodes (PALN) as detected by magnetic resonance image and good performance status for concurrent chemoradiotherapy. Eligible patients were randomized to receive either pretreatment FDG-PET (study group) or not (control group). Whole pelvis was the standard irradiation field for the control group and those with no extrapelvic findings on PET. The radiation fields for the rest of the study group were extended to include the PALN region or were modified according to the extrapelvic PET finding. Results: From January 2002 to April 2006, 129 patients were included, and 66 of them were randomized to receive FDG-PET. PET detected seven extrapelvic metastases (11%, 6 PALN and 1 omental node), and four of them remained disease-free after treatment modification. For patients who underwent PET compared with those who did not, there were no differences in the 4-year rates of overall survival (79% vs. 85%, p = 0.65), disease-free survival (75% vs. 77%, p = 0.64), and distant metastasis-free survival (82% vs. 78%, p = 0.83). Conclusions: Pretreatment FDG-PET in conjunction with magnetic resonance imaging can improve the detection of extrapelvic metastasis, mainly PALN, and help select patients for extended-field radiotherapy. However, the addition of FDG-PET may not translate into survival benefit, even though PALN relapses are reduced.

Tsai, C.-S. [Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, School of Medicine, Taoyuan, Taiwan (China); Lai, C.-H.; Chang, T.-C. [Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Yen, T.-C. [Department of Nuclear Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Ng, K.-K. [Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Hsueh Swei [Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Lee, Steve P. [Department of Radiation Oncology, University of California, Los Angeles, CA (United States); Hong, J.-H., E-mail: jihong@adm.cgmh.org.t [Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, School of Medicine, Taoyuan, Taiwan (China)

2010-02-01T23:59:59.000Z

72

Evolutionary algorithms, chaotic excitations, and structural health monitor : on global search methods for improved damage detection via tailored inputs  

E-Print Network (OSTI)

of detecting damage to offshore oil platforms were lessincreases. If an offshore oil platform is modeled as a 1DOFto monitor offshore oil platforms: feature selection,

Olson, Colin C.

2008-01-01T23:59:59.000Z

73

Multimodal spectroscopy : real-time diagnosis of breast cancer during core needle biopsy  

E-Print Network (OSTI)

Early detection of breast cancer is critical for improved survival. Currently, breast abnormalities are diagnosed based on a histopathological evaluation of tissue removed during core needle biopsy. Microcalcifications are ...

Volynskaya, Zoya I

2010-01-01T23:59:59.000Z

74

Biochemical Control With Radiotherapy Improves Overall Survival in Intermediate and High-Risk Prostate Cancer Patients Who Have an Estimated 10-Year Overall Survival of >90%  

SciTech Connect

Purpose: To identify subgroups of patients with carcinoma of the prostate treated with radical radiotherapy that have improved overall survival when disease is biochemically controlled. Methods and Materials: A cohort of 1,060 prostate cancer patients treated with radical radiotherapy was divided into nine subgroups based on National Comprehensive Cancer Network risk category and estimated 10-year overall survival (eOS 10y) derived from the age adjusted Charlson Comorbidity Index. Patients with and without biochemical control were compared with respect to overall survival. Actuarial estimates of overall survival were calculated using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards models were used for analysis of overall survival. Results: Median follow-up was 125 months (range, 51-176 months). Only the subgroups with high or intermediate risk disease and an eOS 10y of >90% had a statistically significantly improved overall survival when prostate cancer was biochemically controlled. In all other groups, biochemical control made no significant difference to overall survival. In the subgroup with high-risk disease and eOS 10y >90%, actuarial overall survival was 86.3% (95% confidence interval [CI] 78.5%-94.1%) and 62.1% (95% CI 52.9%-71.3%) for patients with biochemical control and biochemical relapse respectively (p = 0.002). In the intermediate risk group with eOS >90%, actuarial overall survival was 95.3% (95% CI 89.0%-100%) and 79.8% (95% CI 68.0%-91.6%) for biochemically controlled and biochemically relapsed patients (p = 0.033). On multivariate analysis, National Comprehensive Cancer Network risk group (p = 0.005), biochemical control (p = 0.033) and eOS 10y (p < 0.001) were statistically significant. Conclusion: Biochemical control translates into improved overall survival in patients with high or intermediate risk disease and an estimated 10-year overall survival of >90%.

Herbert, Christopher, E-mail: cherbert@bccancer.bc.ca [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Liu, Mitchell; Tyldesley, Scott; Morris, W. James [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Joffres, Michel [Department of Health Sciences, Simon Fraser University, Surrey, BC (Canada); Khaira, Mandip; Kwan, Winkle [Department of Radiation Oncology, British Columbia Cancer Agency, Fraser Valley Centre, Surrey, BC (Canada); Moiseenko, Vitali [Department of Medical Physics, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada); Pickles, Thomas [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC (Canada)

2012-05-01T23:59:59.000Z

75

Numeric Definition of the Clinical Performance of the Nested Reverse Transcription-PCR for Detection of Hematogenous Epithelial Cells and Correction for Specific mRNA of Non-Target Cell Origin as Evaluated for Prostate Cancer Cells  

E-Print Network (OSTI)

Background: Inappropriate quality management of reverse transcription-PCR (RT-PCR) assays for the detection of blood-borne prostate cancer (PCa) cells hampers clinical conclusions. Improvement of the RT-PCR methodology for prostate-specific antigen (PSA) mRNA should focus on an appropriate numeric definition of the performance of the assay and correction for PSA mRNA that is not associated with PCa cells. Methods and Results: Repeated (RT-)PCR tests for PSA mRNA in single blood specimens from PCa patients and PCa-free controls, performed by four international institutions, showed a large percentage (?50%) of divergent test results. The best estimates of the mean, ? (SD), of the expected Poisson frequency distributions of the number of positive tests among five replicate assays of

Genetics; Denis Schamhart; Johannes Swinnen; Karl-heinz Kurth; Alex Westerhof; Ron Kusters; Holger Borchers; Cora Sternberg; Nl Den

2003-01-01T23:59:59.000Z

76

Towards automatic power line detection for a UAV surveillance system using pulse coupled neural filter and an improved Hough transform  

Science Conference Proceedings (OSTI)

Spatial information captured from optical remote sensors on board unmanned aerial vehicles (UAVs) has great potential in automatic surveillance of electrical infrastructure. For an automatic vision-based power line inspection system, detecting power ... Keywords: Hough transform, Knowledge-based system, Power line inspection system, Pulse coupled neural filter, Unmanned aerial vehicles (UAVs)

Zhengrong Li; Yuee Liu; Rodney Walker; Ross Hayward; Jinglan Zhang

2010-08-01T23:59:59.000Z

77

The prognostic significance of tumor cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients  

E-Print Network (OSTI)

American Association of Cancer Research Annual Meeting 2008cancer patients. Breast Cancer Research 2011 13:R61. SubmitMolloy et al. Breast Cancer Research 2011, 13:R61 http://

2011-01-01T23:59:59.000Z

78

The Effect of Early Detection of Occult Brain Metastases in HER2-Positive Breast Cancer Patients on Survival and Cause of Death  

SciTech Connect

Purpose: The aim of the study is to evaluate disease-free survival, survival from the detection of brain metastases, overall survival, and cause of death in patients with occult brain metastases (Group I) vs. patients with symptomatic brain metastases (Group II). Methods and Materials: In 80 HER2-positive breast cancer patients, treated with trastuzumab and cytostatic agents for metastatic disease, magnetic resonance imaging screening of the brain was performed, and in 29 patients (36%) occult brain metastasis was detected (Group I). Whole-brain radiotherapy was delivered to Group I. This first group was compared with 52 patients who had symptomatic brain metastases (Group II) and was treated the same way, at the same clinic, during the same time period. Results: Median disease-free survival was 17 months in Group I and 19.9 months in Group II (p = 0.58). The median time interval between the dissemination of the disease and the detection of occult or symptomatic brain metastases was 9 and 15 months, respectively (p = 0.11). When the brain metastases were detected, the median survival was 9 and 8.78 months, respectively (p = 0.80). The median overall survival was 53 and 51 months, respectively (p = 0.94). In the group with occult brain metastases (Group I) 16% of patients died because of progression within the brain. In the group with symptomatic brain metastases (Group II) the rate of cerebral death was 48% (p = 0.009). Conclusions: Whole-brain radiotherapy of occult brain metastases in HER2-positive breast cancer patients with visceral dissemination produces a three-fold decrease in cerebral deaths but does not prolong survival.

Niwinska, Anna, E-mail: alphaonetau@poczta.onet.p [Department of Breast Cancer and Reconstructive Surgery, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland); Tacikowska, Malgorzata [Department of Radiology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland); Murawska, Magdalena [Department of Biostatistics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland)

2010-07-15T23:59:59.000Z

79

Handling Class Overlap and Imbalance to Detect Prompt Situations in Smart Homes  

E-Print Network (OSTI)

such as cancerous cell identification [1], oil- spill detection [2], fraud detection [3], keyword extraction [4

Cook, Diane J.

80

B-Spline Filtering for Automatic Detection of Calcification Lesions in Mammograms  

SciTech Connect

Breast cancer continues to be an important health problem between women population. Early detection is the only way to improve breast cancer prognosis and significantly reduce women mortality. It is by using CAD systems that radiologist can improve their ability to detect, and classify lesions in mammograms. In this study the usefulness of using B-spline based on a gradient scheme and compared to wavelet and adaptative filtering has been investigated for calcification lesion detection and as part of CAD systems. The technique has been applied to different density tissues. A qualitative validation shows the success of the method.

Bueno, G. [E.T.S. Ingenieros Industrials. Universidad de Castilla-La Mancha. Ciudad Real (Spain); Ruiz, M. [Servicio de Patologia Mamaria. Fundacion Rioja Salud (Spain); Sanchez, S

2006-10-04T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
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81

Forward Intensity-Modulated Radiotherapy Planning in Breast Cancer to Improve Dose Homogeneity: Feasibility of Class Solutions  

SciTech Connect

Purpose: To explore forward planning methods for breast cancer treatment to obtain homogeneous dose distributions (using International Commission on Radiation Units and Measurements criteria) within normal tissue constraints and to determine the feasibility of class solutions. Methods and Materials: Treatment plans were optimized in a stepwise procedure for 60 patients referred for postlumpectomy irradiation using strict dose constraints: planning target volume (PTV){sub 95%} of >99%; V{sub 107%} of <1.8 cc; heart V{sub 5Gy} of <10% and V{sub 10Gy} of <5%; and mean lung dose of <7 Gy. Treatment planning started with classic tangential beams. Optimization was done by adding a maximum of four segments before adding beams, in a second step. A breath-hold technique was used for heart sparing if necessary. Results: Dose constraints were met for all 60 patients. The classic tangential beam setup was not sufficient for any of the patients; in one-third of patients, additional segments were required (<3), and in two-thirds of patients, additional beams (<2) were required. Logistic regression analyses revealed central breast diameter (CD) and central lung distance as independent predictors for transition from additional segments to additional beams, with a CD cut-off point at 23.6 cm. Conclusions: Treatment plans fulfilling strict dose homogeneity criteria and normal tissue constraints could be obtained for all patients by stepwise dose intensity modification using limited numbers of segments and additional beams. In patients with a CD of >23.6 cm, additional beams were always required.

Peulen, Heike, E-mail: h.peulen@nki.nl [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands); Hanbeukers, Bianca; Boersma, Liesbeth; Baardwijk, Angela van; Ende, Piet van den; Houben, Ruud; Jager, Jos; Murrer, Lars; Borger, Jacques [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands)

2012-01-01T23:59:59.000Z

82

Detection Apparatus  

DOE Patents (OSTI)

This invention concerns a sensitive apparatus for detecting and counting neutrons, particularly neutrons liberated in an alpha, neutron reaction. The apparatus includes an improved ionization chamber structure together with an improved combination alpha-particle source and holder for the material under test.

Anderson, H.L.

1950-07-31T23:59:59.000Z

83

Fourier Transform Near Infrared Microspectroscopy, Infrared Chemical Imaging, High-Resolution Nuclear Magnetic Resonance and Fluorescence Microspectroscopy Detection of Single Cancer Cells and Single Viral Particles  

E-Print Network (OSTI)

Single Cancer Cells from Human tumors are being detected and imaged by Fourier Transform Infrared (FT-IR), Fourier Transform Near Infrared (FT-NIR)Hyperspectral Imaging and Fluorescence Correlation Microspectroscopy. The first FT-NIR chemical, microscopic images of biological systems approaching one micron resolution are here reported. Chemical images obtained by FT-NIR and FT-IR Microspectroscopy are also presented for oil in soybean seeds and somatic embryos under physiological conditions. FT-NIR spectra of oil and proteins were obtained for volumes as small as two cubic microns. Related, HR-NMR analyses of oil contents in somatic embryos as well as 99% accurate calibrations are also presented here with nanoliter precision. Such high-resolution, 400 MHz H-1 NMR analyses allowed the selection of mutagenized embryos with higher oil content (e.g. >~20%) compared to the average levels in non-mutagenized control embryos. Moreover, developmental changes in single soybean seeds and/or somatic embryos may be monito...

Baianu,I C; Hofmann, N E; Korban, S S; Lozano, P; You, T

2004-01-01T23:59:59.000Z

84

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

Science Conference Proceedings (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

85

Cancer in Australia  

E-Print Network (OSTI)

statistics and information agency. The Institute’s mission is better health and wellbeing for Australians through better health and welfare statistics and information. The Australasian Association of Cancer Registries (AACR) is a collaborative body representing state and territory cancer registries in Australia and New Zealand. Most are members of the International Association of Cancer Registries. The AACR was formed in November 1982 to provide a formal mechanism for promoting uniformity of collection, classification and collation of cancer data. The objectives of the AACR are to: • Achieve national agreement on cancer-specific data definitions and coding and to encourage compliance with such agreements. As far as possible, data definitions and coding should be consistent with existing International Association of Cancer Registries (IACR) protocols and conventions. Facilitate the production of Australian, state and territory and national statistical publications on cancer that are comparable with each other and with international statistical publications. Improve the operational efficiency, and data completeness and quality, of the state and territory and New Zealand cancer registries through collaborative sharing of information. Contribute to national cancer control development in Australia and New Zealand through the regular and timely publication of local and national cancer statistics and the provision of data for cancer control research and health promotion. Contribute national data to international publications of the IACR. Contribute to international cancer coding and statistical analysis developments via members ’ involvement with IACR. Facilitate national epidemiological research projects on cancer (given appropriate local and AIHW ethics committee approvals).CANCER SERIES Number 28

unknown authors

2004-01-01T23:59:59.000Z

86

Neoadjuvant Radiation Is Associated With Improved Survival in Patients With Resectable Pancreatic Cancer: An Analysis of Data From the Surveillance, Epidemiology, and End Results (SEER) Registry  

Science Conference Proceedings (OSTI)

Purpose: Cancer of the exocrine pancreas is the fifth leading cause of cancer death in the United States. Neoadjuvant chemoradiation has been investigated in several trials as a strategy for downstaging locally advanced disease to resectability. The aim of the present study is to examine the effect of neoadjuvant radiation therapy (RT) vs. other treatments on long-term survival for patients with resectable pancreatic cancer in a large population-based sample group. Methods and Materials: The Surveillance, Epidemiology, and End Results (SEER) registry database (1994-2003) was queried for cases of surgically resected pancreatic cancer. Retrospective analysis was performed. The endpoint of the study was overall survival. Results: Using Kaplan-Meier analysis we found that the median overall survival of patients receiving neoadjuvant RT was 23 months vs. 12 months with no RT and 17 months with adjuvant RT. Using Cox regression and controlling for independent covariates (age, sex, stage, grade, and year of diagnosis), we found that neoadjuvant RT results in significantly higher rates of survival than other treatments (hazard ratio [HR], 0.55; 95% confidence interval, 0.38-0.79; p = 0.001). Specifically comparing adjuvant with neoadjuvant RT, we found a significantly lower HR for death in patients receiving neoadjuvant RT rather than adjuvant RT (HR, 0.63; 95% confidence interval, 0.45-0.90; p = 0.03). Conclusions: This analysis of SEER data showed a survival benefit for the use of neoadjuvant RT over surgery alone or surgery with adjuvant RT in treating pancreatic cancer. Therapeutic strategies that use neoadjuvant RT should be further explored for patients with resectable pancreatic cancer.

Stessin, Alexander M. [Tri-Institutional M.D.-Ph.D. Program, New York, NY (United States); Weill Medical College of Cornell University, New York, NY (United States); Meyer, Joshua E. [New York Presbyterian Hospital, New York, NY (United States); Sherr, David L. [New York Presbyterian Hospital, New York, NY (United States)], E-mail: dls9003@med.cornell.edu

2008-11-15T23:59:59.000Z

87

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

SciTech Connect

Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

2009-06-18T23:59:59.000Z

88

Detecting Temporal Precursor Words and Phrases Using a ...  

RMost research on mammography focuses on image data, not textual reports. ... ••Early detection of breast cancer and other breast abnormalities

89

A Geographic Information System (GIS) Analysis of Cancer Clinical Trial Locations in the State of Georgia by Major Cancer Type.  

E-Print Network (OSTI)

??Improving cancer care through clinical research is a major public health issue. However, in Georgia, the exact number of cancer clinical trials is unknown, indicating… (more)

Parker, Shaunta Shanell

2008-01-01T23:59:59.000Z

90

Does Image-Guided Radiotherapy Improve Toxicity Profile in Whole Pelvic-Treated High-Risk Prostate Cancer? Comparison Between IG-IMRT and IMRT  

SciTech Connect

Purpose: To evaluate the impact of adding image-guided (IG) technique to intensity-modulated radiotherapy (IMRT) on dosimetric avoidance of organs at risk (OAR) and acute toxicities. Methods and Materials: A total of 25 consecutively treated patients (10 from National University Hospital and 15 from University of California San Francisco) with high-risk prostate cancer formed the study cohort. All received definitive IMRT with prophylactic nodal RT. Similar IMRT contouring and planning techniques were used at both centers. At University of California, San Francisco, intraprostatic fiducial markers were used for daily pretreatment on-line corrections (IG-IMRT). In contrast, at the National University Hospital, no fiducial markers were used (IMRT). At University of California, San Francisco, the planning target volume margins to the prostate were 2-3 mm. At the National University Hospital, they were 1 cm circumferentially, except for 0.5 cm posteriorly. The acute rectal and bladder toxicities and dosimetric endpoints to the planning target volume and organs at risk were compared. Results: The planning target volume dose coverage was not significantly different between IMRT and IG-IMRT for the prostate, seminal vesicles, and lymph nodes. The volume of rectum and bladder receiving {>=}40, {>=}60, and {>=}70 Gy were all significantly less using IG-IMRT (p <0.001). IG-IMRT yielded lower acute Radiation Therapy Oncology Group Grade 2 rectal (80% vs. 13%, p = 0.004) and bladder (60% vs. 13%, p = 0.014) toxicities. Conclusions: IG-IMRT, using daily target localization with fiducial markers, permits the use of smaller margins and correspondingly lower doses to the organs at risk, such as the rectum and bladder. These tangible gains appear to translate into lower clinically significant toxicities.

Chung, Hans T. [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore)], E-mail: hanstchung@gmail.com; Xia Ping; Chan, Linda W. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Park-Somers, Eileen [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Roach, Mack [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States)

2009-01-01T23:59:59.000Z

91

Cancer in atomic bomb survivors  

SciTech Connect

This book presents information on the following topics: sampling of atomic bomb survivors and method of cancer detection in Hiroshima and Nagasaki; atomic bomb dosimetry for epidemiological studies of survivors in Hiroshima and Nagasaki; tumor and tissue registries in Hiroshima and Nagasaki; the cancer registry in Nagasaki, with atomic bomb survivor data, 1973-1977; cancer mortality; methods for study of delayed health effects of a-bomb radiation; experimental radiation carcinogenesis in rodents; leukemia, multiple myeloma, and malignant lymphoma; cancer of the thyroid and salivary glands; malignant tumors in atomic bomb survivors with special reference to the pathology of stomach and lung cancer; colorectal cancer among atomic bomb survivors; breast cancer in atomic bomb survivors; and ovarian neoplasms in atomic bomb survirors.

Shigematsu, I.; Kagan, A.

1986-01-01T23:59:59.000Z

92

Bayesian classifier with simplified learning phase for detecting microcalcifications in digital mammograms  

Science Conference Proceedings (OSTI)

Detection of clustered microcalcifications (MCs) in mammograms represents a significant step towards successful detection of breast cancer since their existence is one of the early signs of cancer. In this paper, a new framework that integrates Bayesian ...

Imad Zyout; Ikhlas Abdel-Qader; Christina Jacobs

2009-01-01T23:59:59.000Z

93

Defining the critical hurdles in cancer immunotherapy  

E-Print Network (OSTI)

representing Europe, Japan, China and North America to discuss collaborations to improve development, reagents, drugs and clinical protocols with potential to significantly improve cancer outcomes. Nowhere, China and North

Paris-Sud XI, Université de

94

Quantitative spectroscopy for detection of cervical dysplasia  

E-Print Network (OSTI)

The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection ...

Mirkovi?, Jelena, Ph. D. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

95

Early Salvage Hormonal Therapy for Biochemical Failure Improved Survival in Prostate Cancer Patients After Neoadjuvant Hormonal Therapy Plus Radiation Therapy-A Secondary Analysis of Irish Clinical Oncology Research Group 97-01  

SciTech Connect

Purpose: To assess the survival benefit of early vs late salvage hormonal therapy (HT), we performed a secondary analysis on patients who developed recurrence from Irish Clinical Oncology Research Group 97-01, a randomized trial comparing 4 vs 8 months neoadjuvant HT plus radiation therapy (RT) in intermediate- and high-risk prostate adenocarcinoma. Methods and Materials: A total of 102 patients from the trial who recurred were analyzed at a median follow-up of 8.5 years. The patients were divided into 3 groups based on the timing of salvage HT: 57 patients had prostate-specific antigen (PSA) {<=}10 ng/mL and absent distant metastases (group 1, early), 21 patients had PSA >10 ng/mL and absent distant metastases (group 2, late), and 24 patients had distant metastases (group 3, late). The endpoint analyzed was overall survival (OS) calculated from 2 different time points: date of enrolment in the trial (OS1) and date of initiation of salvage HT (OS2). Survival was estimated using Kaplan-Meier curves and a Cox regression model. Results: The OS1 differed significantly between groups (P<.0005): OS1 at 10 years was 78% in group 1, 42% in group 2, and 29% in group 3. The OS2 also differed significantly between groups (P<.0005): OS2 at 6 years was 70% in group 1, 47% in group 2, and 22% in group 3. Group 1 had the longest median time from end of RT to biochemical failure compared with groups 2 and 3 (3.3, 0.9, and 1.7 years, respectively; P<.0005). Group 1 also had the longest median PSA doubling time compared with groups 2 and 3 (9.9, 3.6, and 2.4 months, respectively; P<.0005). On multivariate analysis, timing of salvage HT, time from end of RT to biochemical failure, and PSA nadir on salvage HT were significant predictors of survival. Conclusion: Early salvage HT based on PSA {<=}10 ng/mL and absent distant metastases improved survival in patients with prostate cancer after failure of initial treatment with neoadjuvant HT plus RT.

Mydin, Aminudin R., E-mail: aminudinrahman@googlemail.com [Department of Radiotherapy and Oncology, Kuala Lumpur Hospital, Kuala Lumpur (Malaysia); Dunne, Mary T.; Finn, Marie A. [Clinical Trials Resource Unit, St. Luke's Hospital, Dublin (Ireland)] [Clinical Trials Resource Unit, St. Luke's Hospital, Dublin (Ireland); Armstrong, John G. [Department of Radiation Oncology, St. Luke's Hospital, Dublin (Ireland)] [Department of Radiation Oncology, St. Luke's Hospital, Dublin (Ireland)

2013-01-01T23:59:59.000Z

96

Available Technologies: Detecting and Treating Breast Cancer ...  

Mina Bissell and colleagues have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cance ...

97

Using Dashboards to Improve Energy and Comfort in Federal Buildings  

E-Print Network (OSTI)

detection to identify energy waste in a specific building,detect system anomalies or energy waste. Notice gas used forenergy consumption, comfort improvements, retro commissioning, and anomaly detection. • Identify areas of waste and

Marini, Kyle

2011-01-01T23:59:59.000Z

98

A Graph Analytical Approach for Topic Detection  

Science Conference Proceedings (OSTI)

Topic detection with large and noisy data collections such as social media must address both scalability and accuracy challenges. KeyGraph is an efficient method that improves on current solutions by considering keyword cooccurrence. We show that KeyGraph ... Keywords: KeyGraph-based Topic Detection, Topic detection, community detection, network analysis

Hassan Sayyadi, Louiqa Raschid

2013-12-01T23:59:59.000Z

99

Predictive and therapeutic markers in ovarian cancer  

DOE Patents (OSTI)

Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

2013-03-26T23:59:59.000Z

100

Usability of mobile computing technologies to assist cancer patients  

Science Conference Proceedings (OSTI)

Medical researchers are constantly looking for new methods for early detection and treatment of incurable diseases. Cancer can severely hinder the lives of patients if they are not constantly attended to. Cancer patients can be assisted with the aid ... Keywords: MARKS, TinyOS, cancer, chemotherapy, mote, pervasive health care, tmote sky, wellness monitor

Rezwan Islam; Sheikh I. Ahamed; Nilothpal Talukder; Ian Obermiller

2007-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Refractory Improvement  

NLE Websites -- All DOE Office Websites (Extended Search)

Refractory Improvement Refractory Improvement NETL Office of Research and Development Project Number: FWP-2012.03.03 Task 2 Project Description Industry would like gasifier on-line availability of 85-95% for utility applications and 95% for applications such as chemical production. Gasification facilities' are currently unable to meet these requirements, which have created a potential roadblock to widespread acceptance and commercialization of gasification technologies. Refractory liners and syngas coolers are among key components of the gasification process previously identified as negatively impacting gasifier availability. Ash originating from impurities in the gasifier's carbon feedstock is the root cause of many problems impacting gasifier RAM (Reliability Availability Maintainability). At the high temperatures of gasification, ash changes to liquid, gas, and solid phases which wear down refractory materials and can cause fouling, either of which can lead to unplanned shutdowns for system repair, replacement, or cleaning.

102

Nanoparticles in cancer imaging and therapy  

Science Conference Proceedings (OSTI)

Nanoparticle contrast agents offer the potential to significantly improve existing methods of cancer diagnosis and treatment. Advantages include biocompatibility, selective accumulation in tumor cells, and reduced toxicity. Considerable research is underway ...

Leon Smith; Zdenka Kuncic; Kostya Ostrikov; Shailesh Kumar

2012-01-01T23:59:59.000Z

103

Combination of fluorescence imaging and local spectrophotometry in fluorescence diagnostics of early cancer of larynx and bronchi  

SciTech Connect

The results of comparative studies of autofluorescence and 5-ALA-induced fluorescence of protoporphyrin IX, used in the diagnostics of early cancer of larynx and bronchi, are presented. The autofluorescence and 5-ALA-induced fluorescence images of larynx and bronchial tissues are analysed during the endoscopic study. The method of local spectrophotometry is used to verify findings obtained from fluorescence images. It is shown that such a combined approach can be efficiently used to improve the diagnostics of precancer and early cancer, to detect a primary multiple tumours, as well as for the diagnostics of a residual tumour or an early recurrence after the endoscopic, surgery or X-ray treatment. The developed approach allows one to minimise the number of false-positive results and to reduce the number of biopsies, which are commonly used in the white-light bronchoscopy search for occult cancerous loci. (laser biology and medicine)

Sokolov, Vladimir V; Filonenko, E V; Telegina, L V [P.A. Hertsen Moscow Research Oncological Institute, Moscow (Russian Federation); Boulgakova, N N; Smirnov, V V [A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

2002-11-30T23:59:59.000Z

104

Improved ion detector  

DOE Patents (OSTI)

An improved ion detector device of the ionization detection device chamber type comprises an ionization chamber having a central electrode therein surrounded by a cylindrical electrode member within the chamber with a collar frictionally fitted around at least one of the electrodes. The collar has electrical contact means carried in an annular groove in an inner bore of the collar to contact the outer surface of the electrode to provide electrical contact between an external terminal and the electrode without the need to solder leads to the electrode.

Tullis, A.M.

1986-01-30T23:59:59.000Z

105

A novel tactile sensor for detecting lumps in breast tissue  

Science Conference Proceedings (OSTI)

We developed a compact tactile sensor in order to guide the clinician or the self-user for non-invasive detection of lumps. The new design has an advantage over the existing discrete tactile sensors and detection methods by efficiently sensing force ... Keywords: artificial palpation, breast cancer, haptics, lump detection, optical array sensor, tactile mapping

Mehmet Ayyildiz; Burak Guclu; Mustafa Z. Yildiz; Cagatay Basdogan

2010-07-01T23:59:59.000Z

106

Detection device  

DOE Patents (OSTI)

The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

Smith, J.E.

1981-02-27T23:59:59.000Z

107

Bonus -- Cameras Designed to Strengthen Nuclear Security Can Also Detect  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

to Strengthen Nuclear Security Can Also to Strengthen Nuclear Security Can Also Detect Cancer Bonus -- Cameras Designed to Strengthen Nuclear Security Can Also Detect Cancer November 17, 2010 - 4:02pm Addthis Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs What does this mean for me? The cameras can detect prostate cancer -- as well as cervical, colorectal and breast cancers -- and can be optimized as a surgical probe that guides the removal of cancerous tumors. Brookhaven National Laboratory (BNL) and Hybridyne Imaging Technologies, Inc. recently won the 2010 North American Frost & Sullivan Award for Technology Innovation of the Year. The award is given out each year to a company that finds a new application for a unique technology. With funding from the Energy Department's NNSA's Office of Nonproliferation and

108

Acoustic enhancement for photo detecting devices  

DOE Patents (OSTI)

Provided are improvements to photo detecting devices and methods for enhancing the sensitivity of photo detecting devices. A photo detecting device generates an electronic signal in response to a received light pulse. An electro-mechanical acoustic resonator, electrically coupled to the photo detecting device, damps the electronic signal and increases the signal noise ratio (SNR) of the electronic signal. Increased photo detector standoff distances and sensitivities will result.

Thundat, Thomas G; Senesac, Lawrence R; Van Neste, Charles W

2013-02-19T23:59:59.000Z

109

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells  

E-Print Network (OSTI)

Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ...

Papa, Anne-Laure

110

Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals  

DOE Patents (OSTI)

The invention discloses improved reagents containing antibodies against stage specific embryonic antigen-1 antibodies and improved methods for detection of occult abscess and inflammation using the improved reagents.

Thakur, Madhukar L. (Cherry Hill, NJ)

1990-01-01T23:59:59.000Z

111

Spectroscopic detection  

DOE Patents (OSTI)

In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.

Woskov, Paul P. (Bedford, MA); Hadidi, Kamal (Cambridge, MA)

2003-01-01T23:59:59.000Z

112

A texture analysis method for detection of clustered microcalcifications on digital mammograms  

Science Conference Proceedings (OSTI)

Breast cancer is one of the major causes of death among women. Early detection of breast cancer is possible by the detection of clustered microcalcifications on X-ray mammograms. Texture is an important characteristic used in identifying objects or region ...

M. C. Barretto; D. A. Kulkarni; G. R. Udupi

2012-10-01T23:59:59.000Z

113

Is Adjuvant Chemoradiotherapy Overtreatment in Cervical Cancer Patients With Intermediate Risk Factors?  

Science Conference Proceedings (OSTI)

Purpose: To determine whether adjuvant chemoradiotherapy (CRT) improves the outcome of cervical cancer patients with intermediate risk factors. Methods and Materials: Between January 2000 and June 2006, the medical records of 735 patients who had undergone radical surgery for Stage IB-IIA cervical cancer were reviewed retrospectively. Of the 735 patients, 172 with two or more intermediate risk factors (i.e., lymphovascular space involvement, deep stromal invasion, and tumor size {>=}2 cm) were grouped as follows according to the adjuvant treatment received: 34 patients, no further treatment; 49 patients, RT; and 89 patients, CRT. The significance of the clinical parameters and recurrence-free survival of each group were analyzed. Results: Of the 172 patients with any of the intermediate risk factors, 137 (79.6%) had two or more intermediate risk factors. Of the 172 patients, 12 developed recurrences (6.4%)->(7.0%), with 6 in the pelvis and 6 in distant sites. All 12 recurrences occurred in those who had two or more intermediate risk factors (sensitivity, 100%); however, only six recurrences were detected in patients who met the Gynecologic Oncology Group criteria for the intermediate-risk group (sensitivity, 50%; Z test, p .05). Conclusion: Postoperative adjuvant CRT can improve the outcome of cervical cancer patients with intermediate risk factors, with low increase in toxicity.

Ryu, Sang-Young, E-mail: ryu@kcch.re.k [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Park, Sang-Il [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Nam, Byung-Ho [Center for Clinical Trials, National Cancer Center, Kyongi (Korea, Republic of); Cho, Chul-Koo [Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Kidong; Kim, Beob-Jong; Kim, Moon-Hong; Choi, Seok-Cheol; Lee, Eui-Don; Lee, Kyoung-Hee [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

2011-03-01T23:59:59.000Z

114

Radon detection  

DOE Patents (OSTI)

A detector for atmospheric radon using a long range alpha detector as its sensing element is described. An electrostatic filter removes ions from ambient air, while allowing radon atoms to pass into a decay cavity. Here, radon atoms are allowed to decay, creating air ions. These air ions are drawn by a fan through a second electrostatic filter which can be activated or deactivated, and into the long range alpha detector. With the second electrostatic filter activated, no air ions are allowed to pass, and the signal output from the long range alpha detector consists of only the electronic background. With the second electrostatic filter deactivated, air ions and cosmic rays will be detected. The cosmic ray contribution can be minimized by shielding. 3 figures.

MacArthur, D.W.; Allander, K.S.; Bounds, J.A.

1994-01-25T23:59:59.000Z

115

Radon detection  

DOE Patents (OSTI)

A detector for atmospheric radon using a long range alpha detector as its sensing element. An electrostatic filter removes ions from ambient air, while allowing radon atoms to pass into a decay cavity. Here, radon atoms are allowed to decay, creating air ions. These air ions are drawn by a fan through a second electrostatic filter which can be activated or deactivated, and into the long range alpha detector. With the second electrostatic filter activated, no air ions are allowed to pass, and the signal output from the long range alpha detector consists of only the electronic background. With the second electrostatic filter deactivated, air ions and cosmic rays will be detected. The cosmic ray contribution can be minimized by shielding.

MacArthur, Duncan W. (Los Alamos, NM); Allander, Krag S. (Ojo Caliente, NM); Bounds, John A. (Los Alamos, NM)

1994-01-01T23:59:59.000Z

116

Detecting model refactoring opportunities using heuristic search  

Science Conference Proceedings (OSTI)

Model-driven engineering (MDE) is an approach to software development where the primary focus is on models. To improve their quality, models continually evolve due, for example, to the detection of "bad design practices", called design defects. Presence ...

Adnane Ghannem; Marouane Kessentini; Ghizlane El Boussaidi

2011-11-01T23:59:59.000Z

117

Multiple clues for license plate detection and recognition  

Science Conference Proceedings (OSTI)

This paper addresses a license plate detection and recognition (LPR) task on still images of trucks. The main contribution of our LPR system is the fusion of different segmentation algorithms used to improve the license plate detection. We also compare ...

Pablo Negri; Mariano Tepper; Daniel Acevedo; Julio Jacobo; Marta Mejail

2010-11-01T23:59:59.000Z

118

Fuel washout detection system  

DOE Patents (OSTI)

A system for detecting grossly failed reactor fuel by detection of particulate matter as accumulated on a filter.

Colburn, Richard P. (Pasco, WA)

1985-01-01T23:59:59.000Z

119

Accelerators for Cancer Therapy  

DOE R&D Accomplishments (OSTI)

The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

Lennox, Arlene J.

2000-05-30T23:59:59.000Z

120

Detection of process anomalies using an improved statistical learning framework  

Science Conference Proceedings (OSTI)

Maintenance technologies have been progressed from a time-based to a condition-based manner. The fundamental idea of condition-based maintenance (CBM) is built on the real-time diagnosis of impending failures and/or the prognosis of residual lifetime ... Keywords: Condition-based maintenance, Kernel regression, Process anomalies, Sensor anomalies, Statistical learning

Sang Ha An; Gyunyoung Heo; Soon Heung Chang

2011-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Diamondoids Improve Electron Emitters  

NLE Websites -- All DOE Office Websites (Extended Search)

Diamondoids Improve Electron Emitters Diamondoids Improve Electron Emitters Print Monday, 17 September 2012 12:02 Diamondoids are nanoparticles made of only a handful of carbon...

122

Pulsed helium ionization detection system  

DOE Patents (OSTI)

A helium ionization detection system is provided which produces stable operation of a conventional helium ionization detector while providing improved sensitivity and linearity. Stability is improved by applying pulsed dc supply voltage across the ionization detector, thereby modifying the sampling of the detectors output current. A unique pulse generator is used to supply pulsed dc to the detector which has variable width and interval adjust features that allows up to 500 V to be applied in pulse widths ranging from about 150 nsec to about dc conditions.

Ramsey, R.S.; Todd, R.A.

1985-04-09T23:59:59.000Z

123

The use of polarized light for skin cancer detecton  

E-Print Network (OSTI)

Over 50,000 people per year will be diagnosed with skin cancer in one of its various forms, making it the seventh most common form of cancer in the United States. Currently the only method to diagnose suspicious lesions is visual inspection and subsequent biopsy of suspicious lesions. Many cancerous lesions are missed and many benign lesions are biopsied using these techniques. This process is painful and expensive. The proposed research is driven by the need for a non-invasive skin cancer detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments are performed to simulate changes in tissue, such as increased size of scatterers and increased scattering and absorption coefficients that often accompany tissue changes as it becomes cancerous. The effects of these simulated changes are tested on the Polarimetric imaging system in order to quantify changes in the Mueller matrix caused by the perturbations, and ultimately to relate them to observed changes in the Mueller matrices of cancerous and non-cancerous tissue. Finally, the Polarimetric imaging system is used to determine the Mueller matrix of cancerous and non-cancerous tissue to assess the system's capabilities for skin cancer diagnosis.

DeLaughter, Aimee Hill

2002-01-01T23:59:59.000Z

124

Quantification of differences in the effective atomic numbers of healthy and cancerous tissues: A discussion in the context of diagnostics and dosimetry  

Science Conference Proceedings (OSTI)

Purpose: There are a range of genetic and nongenetic factors influencing the elemental composition of different human tissues. The elemental composition of cancerous tissues frequently differs from healthy tissue of the same organ, particularly in high-Z trace element concentrations. For this reason, one could suggest that this may be exploited in diagnostics and perhaps even influence dosimetry. Methods: In this work, for the first time, effective atomic numbers are computed for common cancerous and healthy tissues using a robust, energy-dependent approach between 10 keV and 100 MeV. These are then quantitatively compared within the context of diagnostics and dosimetry. Results: Differences between effective atomic numbers of healthy and diseased tissues are found to be typically less than 10%. Fibrotic tissues and calcifications of the breast exhibit substantial (tens to hundreds of percent) differences to healthy tissue. Expectedly, differences are most pronounced in the photoelectric regime and consequently most relevant for kV imaging/therapy and radionuclides with prominent low-energy peaks. Cancerous tissue of the testes and stomach have lower effective atomic numbers than corresponding healthy tissues, while diseased tissues of the other organ sites typically have higher values. Conclusions: As dose calculation approaches improve in accuracy, there may be an argument for the explicit inclusion of pathologies. This is more the case for breast, penile, prostate, nasopharyngeal, and stomach cancer, less so for testicular and kidney cancer. The calculated data suggest dual-energy computed tomography could potentially improve lesion identification in the aforementioned organs (with the exception of testicular cancer), with most import in breast imaging. Ultimately, however, the differences are very small. It is likely that the assumption of a generic 'tissue ramp' in planning will be sufficient for the foreseeable future, and that the Z differences do not notably aid lesion detection beyond that already facilitated by differences in mass density.

Taylor, M. L. [School of Applied Sciences and Health Innovation Research Institute, RMIT University, Melbourne 3000 (Australia); Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne 3001 (Australia) and Medical Physics, WBRC, Alfred Hospital, Melbourne 3000 (Australia)

2012-09-15T23:59:59.000Z

125

Bonus -- Cameras Designed To Strengthen Nuclear Security Can Also Detect  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

To Strengthen Nuclear Security Can Also To Strengthen Nuclear Security Can Also Detect Cancer Bonus -- Cameras Designed To Strengthen Nuclear Security Can Also Detect Cancer November 17, 2010 - 4:04pm Addthis Ginny Simmons Ginny Simmons Former Managing Editor for Energy.gov, Office of Public Affairs What does this mean for me? Thanks to researchers from Brookhaven National Laboratory, a high-resolution gamma camera exists that can be used to detect prostate cancer. Brookhaven National Laboratory (BNL) and Hybridyne Imaging Technologies, Inc. recently won the 2010 North American Frost & Sullivan Award for Technology Innovation of the Year. The award is given out each year to a company that finds a new application for a unique technology. With funding from the Department of Energy's NNSA's Office of Nonproliferation and

126

Computer-aided detection for ultra-low-dose CT colonography  

Science Conference Proceedings (OSTI)

To screen large populations for colorectal cancer, it may be necessary to reduce the radiation dose of computed tomographic colonography (CTC) examinations. We compared the accuracy of computer-aided detection (CAD) in standard-dose (SD) CTC with that ... Keywords: computed tomographic colonography, computer-aided detection, diffusion, dose, polyp detection, virtual colonoscopy

Janne J. Näppi; Masanori Imuta; Yasuyuki Yamashita; Hiroyuki Yoshida

2012-10-01T23:59:59.000Z

127

Improving Relocatable Classroom HVAC For Improved IEQ And Energy...  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving Relocatable Classroom HVAC For Improved IEQ And Energy Efficiency Title Improving Relocatable Classroom HVAC For Improved IEQ And Energy Efficiency Publication Type...

128

How to Detect Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

How to Detect Radiation How to Survey Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Detection How...

129

Improved resolution and reduced clutter in ultra-wideband microwave imaging using cross-correlated back projection: experimental and numerical results  

Science Conference Proceedings (OSTI)

Microwave breast cancer detection is based on the dielectric contrast between healthy and malignant tissue. This radar-based imaging method involves illumination of the breast with an ultra-wideband pulse. Detection of tumors within the breast is achieved ...

S. Jacobsen; Y. Birkelund

2010-01-01T23:59:59.000Z

130

Cancer Due to Prolonged Inflammation  

E-Print Network (OSTI)

Development. Molecular Cancer Research 4.221 (2006): 5-261.direction of future cancer research is to better understand

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

131

Questions and Answers About Female Breast Cancer What is Breast Cancer?  

E-Print Network (OSTI)

the radiation from a mammogram? Should I worry about this? Data from the atomic bomb survivors and other groups. The single most effective way a woman can detect early breast cancer is through routine mammography medical history · Physical exam which includes palpation of the breast and nearby lymph nodes · Imaging

132

Biospecimen Reporting for Improved Study Quality  

E-Print Network (OSTI)

Professor in Breast Cancer Research, University of MichiganSymposium: Advancing Cancer Research through BiospecimenH. Lee Moffitt Cancer Center and Research Institute, Tampa,

Moore, Ph.D., Helen M.

2011-01-01T23:59:59.000Z

133

Biospecimen Reporting for Improved Study Quality (BRISQ)  

E-Print Network (OSTI)

Symposium: Advancing Cancer Research through BiospecimenH. Lee Moffitt Cancer Center & Research Institute StellaH. Lee Moffitt Cancer Center & Research Institute Stella

Jewell, Ph.D., Scott D.

2011-01-01T23:59:59.000Z

134

To Improve Lung Cancer Diagnosis, Good Medicine Is a ...  

Science Conference Proceedings (OSTI)

... The team encased the mimics in foam rubber and put them into layered racks of a box akin to one that holds fishing tackle. ...

2010-10-05T23:59:59.000Z

135

Shark cartilage and cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

speculation in the past that there may be some factor in shark's cartilage that prevents cancer, recent research by the National Cancer Institute could not confirm this, and there...

136

Soy and breast cancer  

Science Conference Proceedings (OSTI)

Are soy foods safe for breast cancer patients? Soy is a rich source of isoflavones (primarily genistein, daidzein, and glycitein). The standard oral therapy undertaken after initial treatment (known as “adjuvant therapy”) for estrogen-sensitive cancers is

137

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents (OSTI)

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

138

Portable modular detection system  

Science Conference Proceedings (OSTI)

Disclosed herein are portable and modular detection devices and systems for detecting electromagnetic radiation, such as fluorescence, from an analyte which comprises at least one optical element removably attached to at least one alignment rail. Also disclosed are modular detection devices and systems having an integrated lock-in amplifier and spatial filter and assay methods using the portable and modular detection devices.

Brennan, James S. (Rodeo, CA); Singh, Anup (Danville, CA); Throckmorton, Daniel J. (Tracy, CA); Stamps, James F. (Livermore, CA)

2009-10-13T23:59:59.000Z

139

Radiation Detection Instruments  

Science Conference Proceedings (OSTI)

Directory of Accredited Laboratories. Radiation Detection Instruments. In 2005, the Department of Homeland Security requested ...

2013-09-06T23:59:59.000Z

140

ENVIRONMENTAL CANCER RISK  

E-Print Network (OSTI)

This report is submitted to the President of the United States in fulfillment of the obligations of the President’s Cancer Panel to appraise the National Cancer Program as established in accordance with the National Cancer Act of 1971 (P.L. 92-218), the

Margaret L. Kripke, Ph.D.; Abby B. S, Ph.D.; Suzanne H. Reuben

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Compensated intruder-detection systems  

DOE Patents (OSTI)

The invention is an improvement to an intruder-detection system of the kind where intruder-induced signals are transmitted through a medium whose conductance varies with certain climatic conditions. The improved system includes means coupled to the medium for converting the intruder-induced signals received therefrom to a first electrical signal. Means also are provided for generating a reference signal proportional to the climate-induced changes in the signal-conductance of the medium. Means are provided for generating, from the first electrical signal and the reference signal, an electrical output signal which is unaffected by the changes in signal-conductance. Means are provided to give warning when the output signal exceeds a selected value. In another aspect, the invention is a method for operating an intruder-detection system of the kind wherein an intrusion-generated signal transmitted through a detection medium is converted to a first electrical signal. The first electrical signal contains variations resulting from climate-induced changes in the medium. The method of the invention comprises generating an electrical reference signal proportional to the climate-induced changes in the medium; conditioning the first signal with the reference signal to produce an electrical output signal which is unaffected by the climate-induced changes in the medium; and impressing the resulting output signal across an alarm circuit to actuate the same when the output signal exceeds a selected value.

McNeilly, D.R.; Miller, W.R.

1982-01-20T23:59:59.000Z

142

Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies  

Science Conference Proceedings (OSTI)

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

2012-07-01T23:59:59.000Z

143

Advanced technologies for perimeter intrusion detection sensors  

SciTech Connect

The development of integrated circuit fabrication techniques and the resulting devices have contributed more to the advancement of exterior intrusion detectors and alarm assessment devices than any other technology. The availability of this technology has led to the improvements in and further development of smaller more powerful computers, microprocessors, solid state memories, solid state cameras, thermal imagers, low-power lasers, and shorter pulse width and higher frequency electronic circuitry. This paper presents information on planning a perimeter intrusion detection system, identifies the site characteristics that affect its performance, and describes improvements to perimeter intrusion detection sensors and assessment devices that have been achieved by using integrated circuit technology.

Williams, J.D.

1995-03-01T23:59:59.000Z

144

Improved Perturbation Theory for Improved Lattice Actions  

E-Print Network (OSTI)

We study a systematic improvement of perturbation theory for gauge fields on the lattice; the improvement entails resumming, to all orders in the coupling constant, a dominant subclass of tadpole diagrams. This method, originally proposed for the Wilson gluon action, is extended here to encompass all possible gluon actions made of closed Wilson loops; any fermion action can be employed as well. The effect of resummation is to replace various parameters in the action (coupling constant, Symanzik coefficients, clover coefficient) by ``dressed'' values; the latter are solutions to certain coupled integral equations, which are easy to solve numerically. Some positive features of this method are: a) It is gauge invariant, b) it can be systematically applied to improve (to all orders) results obtained at any given order in perturbation theory, c) it does indeed absorb in the dressed parameters the bulk of tadpole contributions. Two different applications are presented: The additive renormalization of fermion masses, and the multiplicative renormalization Z_V (Z_A) of the vector (axial) current. In many cases where non-perturbative estimates of renormalization functions are also available for comparison, the agreement with improved perturbative results is significantly better as compared to results from bare perturbation theory.

M. Constantinou; H. Panagopoulos; A. Skouroupathis

2006-05-31T23:59:59.000Z

145

Detection of pump degradation  

Science Conference Proceedings (OSTI)

There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous spectral vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition: advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed.

Casada, D.

1994-12-31T23:59:59.000Z

146

Defining the Critical Hurdles in Cancer Immunotherapy  

E-Print Network (OSTI)

Australia. Ovarian Cancer Research Center, University ofal: New models for cancer research: human cancer stem cellAmerican Association for Cancer Research 2010, 16:2861-71.

2011-01-01T23:59:59.000Z

147

High sensitivity leak detection method and apparatus  

DOE Patents (OSTI)

An improved leak detection method is provided that utilizes the cyclic adsorption and desorption of accumulated helium on a non-porous metallic surface. The method provides reliable leak detection at superfluid helium temperatures. The zero drift that is associated with residual gas analyzers in common leak detectors is virtually eliminated by utilizing a time integration technique. The sensitivity of the apparatus of this disclosure is capable of detecting leaks as small as 1 [times] 10[sup [minus]18] atm cc sec[sup [minus]1]. 2 figs.

Myneni, G.R.

1994-09-06T23:59:59.000Z

148

High sensitivity leak detection method and apparatus  

DOE Patents (OSTI)

An improved leak detection method is provided that utilizes the cyclic adsorption and desorption of accumulated helium on a non-porous metallic surface. The method provides reliable leak detection at superfluid helium temperatures. The zero drift that is associated with residual gas analyzers in common leak detectors is virtually eliminated by utilizing a time integration technique. The sensitivity of the apparatus of this disclosure is capable of detecting leaks as small as 1.times.10.sup.-18 atm cc sec.sup.-1.

Myneni, Ganapatic R. (Grafton, VA)

1994-01-01T23:59:59.000Z

149

Agricultural Improvement Loan Program  

Energy.gov (U.S. Department of Energy (DOE))

The Agricultural Improvement Loan Program is administered by the Minnesota Department of Agriculture through the Minnesota Rural Finance Authority (RFA) and provides loans to farmers for...

150

Your Improvement Suggestions Requested  

Science Conference Proceedings (OSTI)

... Once you have joined, click on the Subgroup tab and chose Improvement Day 2010. By E-mail. If you can't create a LinkedIn ...

2010-12-22T23:59:59.000Z

151

Ionization detection system for aerosols  

DOE Patents (OSTI)

This invention relates to an improved smoke-detection system of the ionization-chamber type. In the preferred embodiment, the system utilizes a conventional detector head comprising a measuring ionization chamber, a reference ionization chamber, and a normally non-conductive gas triode for discharging when a threshold concentration of airborne particulates is present in the measuring chamber. The improved system utilizes a measuring ionization chamber which is modified to minimize false alarms and reductions in sensitivity resulting from changes in ambient temperature. In the preferred form of the modification, an annular radiation shield is mounted about the usual radiation source provided to effect ionization in the measuring chamber. The shield is supported by a bimetallic strip which flexes in response to changes in ambient temperature, moving the shield relative to the source so as to vary the radiative area of the source in a manner offsetting temperature-induced variations in the sensitivity of the chamber.

Jacobs, Martin E. (Chillicothe, OH)

1977-01-01T23:59:59.000Z

152

Intrusion Detection: Characterising intrusion detection sensors  

Science Conference Proceedings (OSTI)

An intrusion detection sensor is defined as a device that collects and analyses network traffic for the purpose of identifying suspicious events. Too often the value of a sensor is associated with its data collection and analysis features. Experience ...

Siraj A. Shaikh; Howard Chivers; Philip Nobles; John A. Clark; Hao Chen

2008-09-01T23:59:59.000Z

153

Association between virus, bladder cancers detected using Lawrence...  

NLE Websites -- All DOE Office Websites (Extended Search)

with scientists from the University of Split in Croatia, LLNL and the University of Jordan in Amman is believed to be the first study to demonstrate an association between...

154

Improved plug valve  

DOE Patents (OSTI)

An improved plug valve wherein a novel shape for the valve plug and valve chamber provide mating surfaces for improved wear characteristics is described. The novel shape of the valve plug is a frustum of a body of revolution of a curve known as a tractrix, a solid shape otherwise known as a pseudosphere.

Wordin, J.J.

1986-05-09T23:59:59.000Z

155

Improved wire chamber  

DOE Patents (OSTI)

An improved gas mixture for use with proportional counter devices, such as Geiger-Mueller tubes and drift chambers. The improved gas mixture provides a stable drift velocity while eliminating wire aging caused by prior art gas mixtures. The new gas mixture is comprised of equal parts argon and ethane gas and having approximately 0.25% isopropyl alcohol vapor. 2 figs.

Atac, M.

1987-05-12T23:59:59.000Z

156

Measurement, Analysis, and Improvement  

NLE Websites -- All DOE Office Websites (Extended Search)

6 Measurement, Analysis, and Improvement Process 11_0304 Page 1 of 6 6 Measurement, Analysis, and Improvement Process 11_0304 Page 1 of 6 EOTA - Business Process Document Title: Measurement, Analysis, and Improvement Process Document Number: P-006 Rev 11_0304 Document Owner: Elizabeth Sousa Backup Owner: Melissa Otero Approver(s): Melissa Otero Parent Document: Q-001, Quality Manual Notify of Changes: EOTA Employees Referenced Document(s): P-008 Corrective-Preventive Action Process, P-004 Business System Management Review and REG-003 Records Register P-006 Measurement, Analysis, and Improvement Process 11_0304 Page 2 of 6 Revision History: Rev. Description of Change A Initial Release 08_0416 Changed verbiage in Step 6 to, "CAR/PAR/IO using P-008, Corrective-Preventive Action & Improvement Opportunity"

157

Milestone Plan Process Improvement  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Milestone Plan Process Improvement Milestone Plan Process Improvement Milestone Plan Process Improvement Background In response to our community's concern over the milestone plan (MP) process within the system, the STRIPES Project Office initiated an in-depth evaluation of the required steps and issues surrounding this process. We concluded that the MP process could be improved for most users by tuning the system configuration. With the approval of both the STRIPES Executive Steering Committee and the STRIPES Project Office, we launched the MP Process Improvement Initiative. After many meetings with members of the STRIPES Team and Working Group, we are ready to "go-live" with this initiative. On October 1 st , 2012 the new MP process will be implemented for use by most field offices.

158

Parallelizing data race detection  

Science Conference Proceedings (OSTI)

Detecting data races in multithreaded programs is a crucial part of debugging such programs, but traditional data race detectors are too slow to use routinely. This paper shows how to speed up race detection by spreading the work across multiple cores. ... Keywords: data race detection, uniparallelism

Benjamin Wester; David Devecsery; Peter M. Chen; Jason Flinn; Satish Narayanasamy

2013-04-01T23:59:59.000Z

159

New Improved Equations For Na-K, Na-Li And Sio2 Geothermometers...  

Open Energy Info (EERE)

Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Detection And Rejection Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: New...

160

Discrete Packet Analysis for Improved Atmospheric Rejection on Modulated Laser Signals  

SciTech Connect

This slide-show discusses how the method of discrete packet analysis improves atmospheric compensation for quasi-CW fluorescence detection methods. This is key to improving remote sensing capabilities.

O'Neill, M., McKenna, I., DiBenedetto, J., Capelle, G., Trainham, R.

2012-07-19T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Automated Methods for Multiplexed Pathogen Detection  

Science Conference Proceedings (OSTI)

Detection of pathogenic microorganisms in environmental samples is a difficult process. Concentration of the organisms of interest also co-concentrates inhibitors of many end-point detection methods, notably, nucleic acid methods. In addition, sensitive, highly multiplexed pathogen detection continues to be problematic. The primary function of the BEADS (Biodetection Enabling Analyte Delivery System) platform is the automated concentration and purification of target analytes from interfering substances, often present in these samples, via a renewable surface column. In one version of BEADS, automated immunomagnetic separation (IMS) is used to separate cells from their samples. Captured cells are transferred to a flow-through thermal cycler where PCR, using labeled primers, is performed. PCR products are then detected by hybridization to a DNA suspension array. In another version of BEADS, cell lysis is performed, and community RNA is purified and directly labeled. Multiplexed detection is accomplished by direct hybridization of the RNA to a planar microarray. The integrated IMS/PCR version of BEADS can successfully purify and amplify 10 E. coli O157:H7 cells from river water samples. Multiplexed PCR assays for the simultaneous detection of E. coli O157:H7, Salmonella, and Shigella on bead suspension arrays was demonstrated for the detection of as few as 100 cells for each organism. Results for the RNA version of BEADS are also showing promising results. Automation yields highly purified RNA, suitable for multiplexed detection on microarrays, with microarray detection specificity equivalent to PCR. Both versions of the BEADS platform show great promise for automated pathogen detection from environmental samples. Highly multiplexed pathogen detection using PCR continues to be problematic, but may be required for trace detection in large volume samples. The RNA approach solves the issues of highly multiplexed PCR and provides ''live vs. dead'' capabilities. However, sensitivity of the method will need to be improved for RNA analysis to replace PCR.

Straub, Tim M.; Dockendorff, Brian P.; Quinonez-Diaz, Maria D.; Valdez, Catherine O.; Shutthanandan, Janani I.; Tarasevich, Barbara J.; Grate, Jay W.; Bruckner-Lea, Cindy J.

2005-09-01T23:59:59.000Z

162

Effective Conveyor Belt Inspection for Improved Mining Productivity  

SciTech Connect

This document details progress on the project entitled ''Effective Conveyor Belt Inspection for Improved Mining Productivity'' during the period from November 15, 2004 to May 14, 2004. Highlights include fabrication of an improved LED lightbar, fabrication of a line-scan sensor head for the Smart-Camera based prototype, and development of prototype vulcanized splice detection algorithms.

Chris Fromme

2006-06-01T23:59:59.000Z

163

Effective Conveyor Belt Inspection for Improved Mining Productivity  

SciTech Connect

This document details progress on the project entitled ''Effective Conveyor Belt Inspection for Improved Mining Productivity'' during the period from November 15, 2004 to May 14, 2004. Highlights include fabrication of an improved LED lightbar, fabrication of a line-scan sensor head for the Smart-Camera based prototype, and development of prototype vulcanized splice detection algorithms.

Chris Fromme

2006-06-01T23:59:59.000Z

164

Inhibiting Individual Notch Receptors Improves Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

165

Inhibiting Individual Notch Receptors Improves Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

Inhibiting Individual Notch Inhibiting Individual Notch Receptors Improves Treatment Inhibiting Individual Notch Receptors Improves Treatment Print Wednesday, 27 July 2011 00:00 Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

166

Inhibiting Individual Notch Receptors Improves Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

167

Inhibiting Individual Notch Receptors Improves Treatment  

NLE Websites -- All DOE Office Websites (Extended Search)

Inhibiting Individual Notch Receptors Improves Treatment Print Inhibiting Individual Notch Receptors Improves Treatment Print Notch receptors constitute a family of evolutionarily conserved transmembrane proteins that function as conduits for cell communication, regulating cell fate and growth. Aberrant activation of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team from Bay Area companies Genentech and Exelixis has synthesized highly specialized antibody inhibitors that specifically inhibit only Notch1 or Notch2, acting through a potent and novel mechanism of Notch inhibition. These antibodies, characterized at ALS Beamline 5.0.2, could provide the tools to therapeutically target individual Notch receptors, avoiding the intestinal toxicity ascribed to treatment with more than one, or a pan-Notch, inhibitor.

168

Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals  

DOE Patents (OSTI)

The invention discloses improved reagents containing antibodies against stage specific embryonic antigen-1 antibodies and improved methods for detection of occult abscess and inflammation using the improved reagents. No Drawings

Thakur, M.L.

1990-04-17T23:59:59.000Z

169

Review Genomic approaches to research in lung cancer  

E-Print Network (OSTI)

The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opportunities for improving our understanding of complex diseases such as lung cancer. In particular, we should expect to witness a rapid increase in the rate of discovery of genes involved in lung cancer pathogenesis and we should be able to develop reliable molecular criteria for classifying lung cancers and predicting biological properties of individual tumors. Achieving these goals will require collaboration by scientists with specialized expertise in medicine, molecular biology, and decision-based statistical analysis.

Edward Gabrielson

2000-01-01T23:59:59.000Z

170

Cancer survivorship : understanding the issues faced by cancer survivors.  

E-Print Network (OSTI)

??International research on cancer survivorship has started to identify a range of issues that affect cancer survivors physically, mentally, emotionally and spiritually. These issues can… (more)

Hayward, Penelope Anne

2010-01-01T23:59:59.000Z

171

Cycle Chemistry Improvement Program  

Science Conference Proceedings (OSTI)

The purity of water and steam is central to ensuring fossil plant component availability and reliability. This report, which describes formal cycle chemistry improvement programs at nine utilities, will assist utilities in achieving significant operation and maintenance cost reductions.

1997-04-21T23:59:59.000Z

172

An Improved Humidity Sensor  

Science Conference Proceedings (OSTI)

A common feature of all capacitance humidity sensors is their undesirable hysteresis effect due to the unequal adsorption and desorption of water vapor on the surfaces of their dielectric porous materials. To eliminate this error, an improved ...

Shixuan Pang; Hartmut Graßl; Horst Jäger

1996-10-01T23:59:59.000Z

173

Classified road detection from satellite images based on perceptual organization  

Science Conference Proceedings (OSTI)

Extracting roads from satellite images is an important task in both research and practice. This work presents an improved model for road detection based on the principles of perceptual organization and classification fusion in human vision system (HVS). ...

J. Yang; R. S. Wang

2007-10-01T23:59:59.000Z

174

Research on energy consumption detection system based on OPC technology  

Science Conference Proceedings (OSTI)

For developing of energy consumption detection systems, the system integration becomes more and more difficult. The OPC Object Linking and Embedding OLE for process control technology is used to simplify the problem. The system integration can be improved ...

Changtao Wang; Zhonghua Han; Bin Ma

2013-06-01T23:59:59.000Z

175

An novel vehicle detection method based on wireless magneto-resistive sensor  

Science Conference Proceedings (OSTI)

In recent years, vehicles detection base on the magnetic effect is a major hot spot in the field of vehicles detection. This paper has studied and realized a wireless magneto-resistive sensor based vehicles detection system, and improved the vehicle ... Keywords: optimal threshold value, vehicles detection, wavelet transformation, wireless magneto-resistive sensor

ShangGuan Wei; Wang Jian; Cai Bai-gen; Yin Qin

2009-11-01T23:59:59.000Z

176

Ultrahigh resolution optical coherence tomography for the detection of early stage neoplastic pathologies  

E-Print Network (OSTI)

Identification of changes associated with early stage disease remains a critical objective of clinical detection and treatment. Effective screening and detection is important for improving outcome because advanced disease, ...

Hsiung, Pei-Lin, 1975-

2005-01-01T23:59:59.000Z

177

Improved Conventional Testing of Power Plant Cables  

Science Conference Proceedings (OSTI)

Factors such as mechanical stress, dust and pollution accumulation, moisture, and thermal aging can cause deterioration and ultimately failure of power, control, and instrumentation cables. This report documents physical, chemical, and electrical tests performed on thermally aged power plant cable, with emphasis on improvements in two major electrical diagnostic techniques: low-frequency insulation analysis to probe the bulk condition of cable insulation and partial discharge testing to detect cracks and...

1996-03-14T23:59:59.000Z

178

Real-time phase boundary detection for colonoscopy videos using motion vector templates  

Science Conference Proceedings (OSTI)

Colonoscopy is the preferred screening method currently available for detection of colorectal cancer and its precursor lesions, colorectal polyps. However, recent data suggest that there is a significant miss rate for the detection of polyps in the colon ... Keywords: camera motion estimation, colonoscopy, end of insertion, motion vector templates, motion vectors, phase boundary

Ruwan Nawarathna; JungHwan Oh; Jayantha Muthukudage; Wallapak Tavanapong; Johnny Wong; Piet C. de Groen

2012-10-01T23:59:59.000Z

179

Detection of masses in mammogram images using CNN, geostatistic functions and SVM  

Science Conference Proceedings (OSTI)

Breast cancer occurs with high frequency among the world's population and its effects impact the patients' perception of their own sexuality and their very personal image. This work presents a computational methodology that helps specialists detect breast ... Keywords: Cellular neural networks, Computer-aided detection, Geostatistical functions, Mammogram, Support vector machines

Wener Borges Sampaio; Edgar Moraes Diniz; Aristófanes Corrêa Silva; Anselmo Cardoso de Paiva; Marcelo Gattass

2011-08-01T23:59:59.000Z

180

Sulfide chemiluminescence detection  

DOE Green Energy (OSTI)

A method of chemiluminescently determining a sulfide which is either hydrogen sulfide or methyl mercaptan by reacting the sulfide with chlorine dioxide at low pressure and under conditions which allow a longer reaction time in emission of a single photon for every two sulfide containing species, and thereafter, chemiluminescently detecting and determining the sulfide. The invention also relates not only to the detection method, but the novel chemical reaction and a specifically designed chemiluminescence detection cell for the reaction.

Spurlin, Stanford R. (Ames, IA); Yeung, Edward S. (Ames, IA)

1985-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Sulfide chemiluminescence detection  

DOE Patents (OSTI)

A method is described for chemiluminescently determining a sulfide which is either hydrogen sulfide or methyl mercaptan by reacting the sulfide with chlorine dioxide at low pressure and under conditions which allow a longer reaction time in emission of a single photon for every two sulfide containing species, and thereafter, chemiluminescently detecting and determining the sulfide. The invention also relates not only to the detection method, but the novel chemical reaction and a specifically designed chemiluminescence detection cell for the reaction. 4 figs.

Spurlin, S.R.; Yeung, E.S.

1985-11-26T23:59:59.000Z

182

Neutron-detection apparatus  

DOE Patents (OSTI)

An atomic fission counting apparatus used for neutron detection is provided with spirally curved electrode plates uniformly spaced apart in a circular array and coated with fissile material.

Kopp, M.K.; Valentine, K.H.

1981-04-24T23:59:59.000Z

183

Liquid level detection  

Science Conference Proceedings (OSTI)

This paper discusses a method. It is for detecting presence of a liquid level at a first predetermined point along the depth of a borehole.

Fryer, C.D.; Stie, K.E.; Wedel, M.W.; Stamper, K.R.

1990-11-27T23:59:59.000Z

184

Neutron detection apparatus  

DOE Patents (OSTI)

An atomic fission counting apparatus used for neutron detection is provided with spirally curved electrode plates uniformly spaced apart in a circular array and coated with fissile material.

Kopp, Manfred K. (Oak Ridge, TN); Valentine, Kenneth H. (Lenoir City, TN)

1983-01-01T23:59:59.000Z

185

Machine Learning for Host-based Anomaly Detection by  

E-Print Network (OSTI)

Anomaly detection techniques complement signature based methods for intrusion detection. Machine learning approaches are applied to anomaly detection for automated learning and detection. Traditional host-based anomaly detectors model system call sequences to detect novel attacks. This dissertation makes four key contributions to detect host anomalies. First, we present an unsupervised approach to clean training data using novel representations for system call sequences. Second, supervised learning with system call arguments and other attributes is proposed for enriched modeling. Third, techniques to increase model coverage for improved accuracy are presented. Fourth, we propose spatio-temporal modeling to detect suspicious behavior for mobile hosts. Experimental results on various data sets indicate that our techniques are more effective than traditional methods in capturing attack-based host anomalies. Additionally, our supervised methods create succint models and the computational overhead incurred is reasonable for an online anomaly detection system. iii Acknowledgements An ancient saying in Sanskrit: Matri devo bhava (revere your mother), pitri devo

Gaurav Tandon; Gaurav Tandon; Philip K. Chan, Ph.D.; Marius C. Silaghi, Ph.D.; Georgios C. Anagnostopoulos, Ph.D.; Gaurav Tandon; Dissertation Advisor; Philip K. Chan, Ph.D.

2008-01-01T23:59:59.000Z

186

Theorem-based, data-driven, cyber event detection  

Science Conference Proceedings (OSTI)

Nonlinear dynamics and graph theory may provide a theorem-based path to improve design security and aid detection of anomalous events in cyber applications. Using side-channel information such as power taken from underlying computer components and analyzing ... Keywords: cyber anomaly detection, graph theory, nonlinear dynamics, phasespace analysis, power measurement

Lee M. Hively; J. Todd McDonald

2013-01-01T23:59:59.000Z

187

Model generalization and its implications on intrusion detection  

Science Conference Proceedings (OSTI)

To make up for the incompleteness of the known behaviors of a computing resource, model generalization is utilized to infer more behaviors in the behavior model besides the known behaviors. In principle, model generalization can improve the detection ... Keywords: generalization, intrusion, intrusion detection, machine learning, security, security infrastructure

Zhuowei Li; Amitabha Das; Jianying Zhou

2005-06-01T23:59:59.000Z

188

Guard Rail Detection Using Radar and Vision Data Fusion  

E-Print Network (OSTI)

This paper describes a method for detecting guard rails fusing radar and vision data in order to improve and speed-up vehicle detection algorithms. The method is based on the search for uninterrupted oblique lines that cross an interest area. The interest area is dinamically indicated by a radar sensor. A method to manage overlapping areas is also described. The method's efficiency, both in terms of time saving and correct detection rate, is numerically shown.

For Vehicle Detection; Alberto Broggi; Pietro Cerri; Fabio Oleari; Marco Paterlini

2005-01-01T23:59:59.000Z

189

Apparatus and method for detecting flaws in conductive material  

Science Conference Proceedings (OSTI)

The present invention is an improved sensing unit for detecting flaws in conductive material wherein the sensing coil is positioned away from a datum of either the datum point, the datum orientation, or a combination thereof. Position of the sensing coil away from a datum increases sensitivity for detecting flaws having a characteristic volume less than about 1 mm{sup 3}, and further permits detection of subsurface flaws. Use of multiple sensing coils permits quantification of flaw area or volume.

Hockey, R.L.; Riechers, D.M.

1999-11-16T23:59:59.000Z

190

Apparatus and method for detecting flaws in conductive material  

DOE Patents (OSTI)

The present invention is an improved sensing unit for detecting flaws in conductive material wherein the sensing coil is positioned away from a datum of either the datum point, the datum orientation, or a combination thereof. Position of the sensing coil away from a datum increases sensitivity for detecting flaws having a characteristic volume less than about 1 mm.sup.3, and further permits detection of subsurface flaws. Use of multiple sensing coils permits quantification of flaw area or volume.

Hockey, Ronald L. (Richland, WA); Riechers, Douglas M. (Richland, WA)

1999-01-01T23:59:59.000Z

191

Surveillance Guides - Continous Improvement  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

CONTINUOUS IMPROVEMENT CONTINUOUS IMPROVEMENT 1.0 Objective The objective of this surveillance is to verify that contractor personnel are effectively managing environment, safety, and health issues in a manner that fosters continuous improvement. The activities included in this surveillance help the Facility Representative determine whether safety issues identified through internal contractor, and external DOE or Defense Nuclear Facilities Safety Board evaluation programs are resolved consistent with the level of safety importance. 2.0 References 2.1 DOE O 414.1, Quality Assurance 2.2 DOE O 232.1, Occurrence Reporting and Processing of Operations Information 2.3 DOE-STD-1045-93, Guide to Good Practices for Notifications and Investigations of Abnormal Events 2.4 48 CFR 1970.5204, Department of Energy Acquisition

192

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo  

E-Print Network (OSTI)

Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. ...

Dhar, Shanta

193

Improving Targeted Radionuclide Therapy Using Nuclear Nanotechnology  

E-Print Network (OSTI)

The objectives of this thesis are to produce radioactive antibody-conjugated gold nanoparticles to improve the efficacy of targeted radionuclide therapy for the treatment of cancer, and to demonstrate that this product can be produced at Texas A&M University. We have proposed a method for determining the distribution of radioactive nuclei per nanoparticle, which is critical for determining radiotherapeutic efficacy. Using the distribution of radioactive nuclei per nanoparticle, we have produced methods for calculating the radiative dose to tissue using nano-improved targeted radionuclide therapy, but more importantly we propose procedures to experimentally determine the efficacy of targeted radionuclide therapy improved by application of radioactive nanomaterials in combination with immunotherapy, nanomaterial cytotoxicity, and other cancer therapies such as chemotherapy. These methods can also be used to determine the efficacy of combinatory treatments as a function of time. Characterization of the antibody-nanoparticle attachment is critical; we have demonstrated successful antibody-nanoparticle conjugation using atomic force microscopy, dynamic light scattering, and agarose gel electrophoresis, providing more conclusive evidence of successful conjugation compared to flow cytometry. We provide a mathematical derivation from basic electron-transport principles which demonstrates the theoretical dosimetric advantages of applying radioactive nanomaterials to targeted radionuclide therapy. The general formulae can be applied to any tumor size, any radionuclide, and any pharmacokinetic nanoparticle distribution throughout the body, ultimately allowing a quick method of approximating the necessary activation time and treatment dosage parameters for a specific patient without burdensome Monte Carlo computational simulations. We further demonstrated that nano-TRT dosage to tumors should be considered as a function of radial position rather than average, as the dose across the tumor may be noticeably non-uniform causing some portions of the tumor to receive (potentially) significantly less dose than average.

Evans, Jordan Andrew

2013-05-01T23:59:59.000Z

194

An algorithm designed for improving diagnostic efficiency by setting multi-cutoff values of multiple tumor markers  

Science Conference Proceedings (OSTI)

Currently, tumor markers have been effectively applied for colorectal cancer (CRC) diagnosis. In order to decrease the information loss caused by single cutoff value and improve diagnosis efficiency (DE), we explore the integrative application of multiple ... Keywords: Colorectal cancer (CRC), Cutoff values, Diagnostic efficiency (DE), Genetic algorithm (GA), Rough set theory (RST), Tumor markers

Qiang Su; Jinghua Shi; Ping Gu; Gang Huang; Yan Zhu

2012-04-01T23:59:59.000Z

195

Improved energy sealing capability  

DOE Green Energy (OSTI)

In response to the need for tapping national energy resources, an improved high temperature sealing material has been developed through the sponsorship of the Department of Energy. Parker Seal was selected as one of the technology transferees from L'Garde Inc. and has optimized this transferred technology for further improved performance capabilities and acceptable plant processing. This paper summarizes Parker Seal's testing and evaluation efforts on L'Garde's Y267 transferred technology for a new geothermal and stream service material. This new product, Parker's E962-85 is described in this paper.

Barsoumian, Jerry L.

1982-10-08T23:59:59.000Z

196

Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk  

E-Print Network (OSTI)

Family Institute for Breast Cancer Research Ontario CancerInternational Agency for Research on Cancer, 2000. CancerThe Canadian Cancer Registries Epidemiology Research Group,

2009-01-01T23:59:59.000Z

197

Flaw Detection and Evaluation  

Science Conference Proceedings (OSTI)

Table 2   Planar flaw classification and NDE detection methods...Lack of bonding Forging or rolling lap Casting cold shut Heat treatment cracks Grinding cracks Plating cracks Fatigue cracks Stress-corrosion cracks Welding cracks Lack of fusion Incomplete penetration Brazing debond NDE detection methods Visual Replication microscopy Magnetic particle Magnetic...

198

On Detecting Spatial Outliers  

Science Conference Proceedings (OSTI)

The ever-increasing volume of spatial data has greatly challenged our ability to extract useful but implicit knowledge from them. As an important branch of spatial data mining, spatial outlier detection aims to discover the objects whose non-spatial ... Keywords: algorithm, outlier detection, spatial data mining

Dechang Chen; Chang-Tien Lu; Yufeng Kou; Feng Chen

2008-12-01T23:59:59.000Z

199

Lean blowoff detection sensor  

DOE Patents (OSTI)

Apparatus and method for detecting incipient lean blowoff conditions in a lean premixed combustion nozzle of a gas turbine. A sensor near the flame detects the concentration of hydrocarbon ions and/or electrons produced by combustion and the concentration monitored as a function of time are used to indicate incipient lean blowoff conditions.

Thornton, Jimmy (Morgantown, WV); Straub, Douglas L. (Morgantown, WV); Chorpening, Benjamin T. (Morgantown, WV); Huckaby, David (Morgantown, WV)

2007-04-03T23:59:59.000Z

200

Analytes Detected from Crude, Dirty Samples  

Science Conference Proceedings (OSTI)

... Page 5. Kit-Based Platform Explosives detection Fission product detection Nerve agent detection Bioagent detection DNA Extraction? Page 6. ...

2012-12-07T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Improved vortex reactor system  

DOE Patents (OSTI)

An improved vortex reactor system for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor.

Diebold, James P. (Lakewood, CO); Scahill, John W. (Evergreen, CO)

1995-01-01T23:59:59.000Z

202

Radioimmunoguided surgery using iodine 125 B72. 3 in patients with colorectal cancer  

SciTech Connect

Preliminary data using B72.3 murine monoclonal antibody labeled with iodine 125 suggested that both clinically apparent as well as occult sites of colorectal cancer could be identified intraoperatively using a hand-held gamma detecting probe. We report the preliminary data of a multicenter trial of this approach in patients with primary or recurrent colorectal cancer. One hundred four patients with primary, suspected, or known recurrent colorectal cancer received an intravenous infusion of 1 mg of B72.3 monoclonal antibody radiolabeled with 7.4 x 10 Bq of iodine 125. Twenty-six patients with primary colorectal cancer and 72 patients with recurrent colorectal cancer were examined. Using the gamma detecting probe, 78% of the patients had localization of the antibody in their tumor; this included 75% of primary tumor sites and 63% of all recurrent tumor sites; 9.2% of all tumor sites identified represented occult sites detected only with the gamma detecting probe. The overall sensitivity was 77% and a predictive value of a positive detection was 78%. A total of 30 occult sites in 26 patients were identified. In patients with recurrent cancer, the antibody study provided unique data that precluded resection in 10 patients, and in another eight patients it extended the potentially curative procedure.

Cohen, A.M.; Martin, E.W. Jr.; Lavery, I.; Daly, J.; Sardi, A.; Aitken, D.; Bland, K.; Mojzisik, C.; Hinkle, G. (Memorial Sloan-Kettering Cancer Center, New York, NY (USA))

1991-03-01T23:59:59.000Z

203

Excitation optimization for damage detection  

SciTech Connect

A technique is developed to answer the important question: 'Given limited system response measurements and ever-present physical limits on the level of excitation, what excitation should be provided to a system to make damage most detectable?' Specifically, a method is presented for optimizing excitations that maximize the sensitivity of output measurements to perturbations in damage-related parameters estimated with an extended Kalman filter. This optimization is carried out in a computationally efficient manner using adjoint-based optimization and causes the innovations term in the extended Kalman filter to be larger in the presence of estimation errors, which leads to a better estimate of the damage-related parameters in question. The technique is demonstrated numerically on a nonlinear 2 DOF system, where a significant improvement in the damage-related parameter estimation is observed.

Bement, Matthew T [Los Alamos National Laboratory; Bewley, Thomas R [UCSD

2009-01-01T23:59:59.000Z

204

A Targeted Cancer Treatment using Nanomaterials | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

When Roots Follow the Path of Least Resistance When Roots Follow the Path of Least Resistance Perfecting Catalytic Arrays A Stable Open Framework with Wide Open Spaces Pumping Through the Middle Crust Looking for Ways to Improve Vaccines Against the Deadly Rotavirus Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Targeted Cancer Treatment using Nanomaterials AUGUST 27, 2009 Bookmark and Share Optical fluorescent imaging of the TiO2-mAb binding to the single brain cancer cells. The bare titianium dioxide nanoparticle bonds with an antibody and attaches itself to brain cancer cells. When exposed to concentrated white light, the titanium dioxide creates free radicals of oxygen that cause the cancer cells to die. Image courtesy of Argonne

205

NETL: Power Plant Improvement Initiative  

NLE Websites -- All DOE Office Websites (Extended Search)

PPII Major Demonstrations Power Plant Improvement Initiative (PPII) The Power Plant Improvement Initiative (PPII) was established in October 2000 to further the commercial-scale...

206

Improving Floating Point Compression  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving Improving Floating Point Compression through Binary Masks Leonardo A. Bautista Gomez Argonne National Laboratory Franck Cappello Argonne National Laboratory Abstract-Modern scientific technology such as particle accel- erators, telescopes and supercomputers are producing extremely large amounts of data. That scientific data needs to be processed using systems with high computational capabilities such as supercomputers. Given that the scientific data is increasing in size at an exponential rate, storing and accessing the data is becoming expensive in both, time and space. Most of this scientific data is stored using floating point representation. Scientific applications executed in supercomputers spend a large amount of CPU cycles reading and writing floating point values, making data compression techniques an interesting way to increase computing efficiency.

207

Improved collecting apparatus  

DOE Patents (OSTI)

An improved collecting apparatus for small aquatic or airborne organisms such as plankton, larval fish, insects, etc. The improvement constitutes an apertured removal container within which is retained a collecting bag, and which is secured at the apex of a conical collecting net. Such collectors are towed behind a vessel or vehicle with the open end of the conical net facing forward for trapping the aquatic or airborne organisms within the collecting bag, while allowing the water or air to pass through the apertures in the container. The container is readily removable from the collecting net whereby the collecting bag can be quickly removed and replaced for further sample collection. The collecting bag is provided with means for preventing the bag from being pulled into the container by the water or air following therethrough.

Duncan, C.P.

1981-03-05T23:59:59.000Z

208

Operations Improvement Surveys  

E-Print Network (OSTI)

Exxon Chemical Company developed unique site-wide energy optimization technology in the mid1970's. This technology was applied by means of site energy surveys which were carried out at every major Exxon facility throughout the world during the 1976-1981 timeframe. The first 20% of energy savings, versus the 1972 reference, had already been captured or was in progress via conventional energy conservation methods. The site energy surveys identified attractive investments to save a second 20% of energy use. In early 1982, Exxon Corp. started to apply this same technology to its major facilities to define attractive NO INVESTMENT and LOW INVESTMENT operational improvement savings which could be implemented quickly. This presentation covers Exxon's approach to site energy optimization and the Operations Improvement Survey Program. The Program has identified at many sites, an average of 5% reduction in today's energy costs at No/Low investment plus additional savings in the feedstock and energy supply areas.

Guide, J. J.; O'Brien, W. J.

1984-01-01T23:59:59.000Z

209

Improved solar heating systems  

DOE Patents (OSTI)

An improved solar heating system is described in which the incident radiation of the sun is absorbed on collector panels, transferred to a storage unit and then distributed as heat for a building and the like. The improvement is obtained by utilizing a storage unit comprising separate compartments containing an array of materials having different melting points ranging from 75 to 180/sup 0/F. The materials in the storage system are melted in accordance with the amount of heat absorbed from the sun and then transferred to the storage system. An efficient low volume storage system is provided by utilizing the latent heat of fusion of the materials as they change states in storing ad releasing heat for distribution.

Schreyer, J.M.; Dorsey, G.F.

1980-05-16T23:59:59.000Z

210

Improving PPM Using Dictionaries  

E-Print Network (OSTI)

We propose a method to improve traditional character-based PPM text compression algorithms. Consider a text file as a sequence of alternating words and non-words, the basic idea of our algorithm is to encode non-words and prefixes of words using character-based context models and encode suffixes of words using dictionary models. By using dictionary models, the algorithm can encode multiple characters as a whole, and thus enhance the compression efficiency. The advantages of the proposed algorithm are: 1) it does not require any text preprocessing; 2) it does not need any explicit codeword to identify switch between context and dictionary models; 3) it can be applied to any character-based PPM algorithms without incurring much additional computational cost. Test results show that significant improvements can be obtained over character-based PPM, especially in low order cases.

Hu, Yichuan; Zhang,; Khan, Farooq; Li, Ying

2010-01-01T23:59:59.000Z

211

Membranes Improve Insulation Efficiency  

E-Print Network (OSTI)

It has been determined from extensive tests involving test models and home attics that loose fill and fiber batt insulation does not function as expected by the industry. The reason for this deficiency is current test methods do not accurately predict the magnitude of air infiltration into fiber insulation as used in home attics, radiant heat infiltration into the insulation during summer, or radiant heat loss through the insulation during winter conditions. The use of (1) moisture permeable membranes over the insulation, and (2) layered membranes between fiber batts to form closed cells in the insulation both dramatically improve the efficiency of the fiber insulation. The efficiency of this insulation will be improved to an even greater degree if these membranes reflect radiant heat as well as reduce convection air currents. Extensive tests have also been conducted which show that if moisture permeable membranes are used over fiber insulation, the moisture content of the insulation will be reduced.

Bullock, C. A.

1986-01-01T23:59:59.000Z

212

IMPROVEMENTS IN POWER PLANT  

SciTech Connect

A power plant for nuclear reactors is designed for improved cycle efficiency. In addition to the usual heat exchanger for heat transfer from gaseous reactor coolant to water for vaporization, a second heat exchanger is provided between the first heat exchanger and a point betwveen the intermediate- pressure and low-pressure turbine stages. In this way, interstage reheating of the steam is obtained without passage of the steam back to the first heat exchanger. (D.L.C.) Research Reactors

Peters, M.C.

1961-10-11T23:59:59.000Z

213

Improved vortex reactor system  

DOE Patents (OSTI)

An improved vortex reactor system is described for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor. 12 figs.

Diebold, J.P.; Scahill, J.W.

1995-05-09T23:59:59.000Z

214

Detecting Climate Change  

Science Conference Proceedings (OSTI)

The likelihood ratio of the data for a hypothesis of some change, relative to the hypothesis of no change, is a suitable statistical measure for the detection of climate change. Likelihood ratios calculated on the basis of Angell and Korshover's (...

Edward S. Epstein

1982-08-01T23:59:59.000Z

215

Detection of counterfeit currency  

SciTech Connect

A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.

Burns, Donald A. (Los Alamos, NM)

1998-01-01T23:59:59.000Z

216

Improved Neutron Scintillators Based on Nanomaterials  

SciTech Connect

The development work conducted in this SBIR has so far not supported the premise that using nano-particles in LiFZnS:Ag foils improves their transparency to 420 (or other frequency) light. This conclusion is based solely on the light absorption properties of LiFZnS foils fabricated from nano- and from micro-particles. Furthermore, even for the case of the Gd{sub 2}O{sub 3} foils, the transmission of 420 nm light gained by using nano-particles all but disappears as the foil thickness is increased beyond about 0.2 mm, a practical scintillator thickness. This was not immediately apparent from the preliminary study since no foils thicker than about 0.04 mm were produced. Initially it was believed that the failure to see an improvement by using nano-particles for the LiFZnS foils was caused by the clumping of the particles in Toluene due to the polarity of the ZnS particles. However, we found, much to our surprise, that nano-particle ZnS alone in polystyrene, and in Epoxy, had worse light transmission properties than the micro-particle foils for equivalent thickness and density foils. The neutron detection measurements, while disappointing, are attributable to our inability to procure or fabricate Bulk Doped ZnS nanoparticles. The cause for the failure of nano-particles to improve the scintillation light, and hence improved neutron detection efficiency, is a fundamental one of light scattering within the scintillator. A consequence of PartTec's documentation of this is that several concepts for the fabrication of improved {sup 6}LiFZnS scintillators were formulated that will be the subject of a future SBIR submission.

Dennis Friesel, PhD

2008-06-30T23:59:59.000Z

217

Northeast Regional Cancer Institute's Cancer Surveillance and Risk Factor Program  

Science Conference Proceedings (OSTI)

OBJECTIVES The Northeast Regional Cancer Institute is conducting a program of ongoing epidemiologic research to address cancer disparities in northeast Pennsylvania. Of particular concern are disparities in the incidence of, stage at diagnosis, and mortality from colorectal cancer. In northeast Pennsylvania, age-adjusted incidence and mortality rates for colorectal cancer are higher, and a significantly smaller proportion of new colorectal cancer cases are diagnosed with local stage disease than is observed in comparable national data. Further, estimates of the prevalence of colorectal cancer screening in northeast Pennsylvania are lower than the US average. The Northeast Regional Cancer Institute’s research program supports surveillance of common cancers, investigations of cancer risk factors and screening behaviors, and the development of resources to further cancer research in this community. This project has the following specific objectives: I. To conduct cancer surveillance in northeast Pennsylvania. a. To monitor incidence and mortality for all common cancers, and colorectal cancer, in particular, and b. To document changes in the stage at diagnosis of colorectal cancer in this high-risk, underserved community. II. To conduct a population-based study of cancer risk factors and screening behavior in a six county region of northeast Pennsylvania. a. To monitor and document changes in colorectal cancer screening rates, and b. To document the prevalence of cancer risk factors (especially factors that increase the risk of colorectal cancer) and to identify those risk factors that are unusually common in this community. APPROACH Cancer surveillance was conducted using data from the Northeast Regional Cancer Institute’s population-based Regional Cancer Registry, the Pennsylvania Cancer Registry, and NCI’s SEER program. For common cancers, incidence and mortality were examined by county within the region and compared to data for similar populations in the US. For colorectal cancer, the stage at diagnosis of cases diagnosed in northeast Pennsylvania was compared to data from prior years. A population-based interview study of healthy adults was conducted to document the status of cancer screening and to estimate the prevalence of established cancer risk factors in this community. This study is similar in design to that used by the Centers for Disease Control and Prevention’s (CDC) Behavioral Risk Factor Surveillance System (BRFSS). EXPERIMENTAL METHODS AND PROCEDURES: This program includes two distinct but related projects. The first project uses existing data to conduct cancer surveillance in northeast Pennsylvania, and the second is a population-based study of cancer risk factors and cancer screening behaviors in this same population. HUMAN SUBJECTS CONSIDERATIONS This program includes two projects: cancer surveillance and a population-based study of cancer risk factors and screening behavior. The cancer surveillance project involves only the use of existing aggregate data or de-identified data. As such, the surveillance project is exempt from human subjects considerations. The study of cancer risk factors and screening behaviors includes data from a random sample of adult residents of northeast Pennsylvania who are 18 or more years of age. All races, ethnicities and both sexes are included in proportion to their representation in the population. Subjects are interviewed anonymously by telephone; those who are unable to complete an interview in English are ineligible. This project has been reviewed and approved by the Scranton-Temple Residency Program IRB (IRB00001355), which is the IRB for the Northeast Regional Cancer Institute.

Lesko, Samuel M.

2007-07-31T23:59:59.000Z

218

A toolkit for detecting technical surprise.  

SciTech Connect

The detection of a scientific or technological surprise within a secretive country or institute is very difficult. The ability to detect such surprises would allow analysts to identify the capabilities that could be a military or economic threat to national security. Sandia's current approach utilizing ThreatView has been successful in revealing potential technological surprises. However, as data sets become larger, it becomes critical to use algorithms as filters along with the visualization environments. Our two-year LDRD had two primary goals. First, we developed a tool, a Self-Organizing Map (SOM), to extend ThreatView and improve our understanding of the issues involved in working with textual data sets. Second, we developed a toolkit for detecting indicators of technical surprise in textual data sets. Our toolkit has been successfully used to perform technology assessments for the Science & Technology Intelligence (S&TI) program.

Trahan, Michael Wayne; Foehse, Mark C.

2010-10-01T23:59:59.000Z

219

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability  

E-Print Network (OSTI)

Whole-genome sequencing using massively parallel sequencing technologies enables accurate detection of somatic rearrangements in cancer. Pinpointing large numbers of rearrangement breakpoints to base-pair resolution allows ...

Lander, Eric S.

220

KIDS: keyed intrusion detection system  

Science Conference Proceedings (OSTI)

Since most current network attacks happen at the application layer, analysis of packet payload is necessary for their detection. Unfortunately malicious packets may be crafted to mimic normal payload, and so avoid detection if the anomaly detection method ... Keywords: Kerckhoffs' principle, anomaly detection, keyed IDS, network intrusion detection, word model

Sasa Mrdovic; Branislava Drazenovic

2010-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Improved cycling cryopump  

DOE Patents (OSTI)

The present invention is designed to achieve continuous high efficiency cryopumping of a vacuum vessel by improving upon and combining in a novel way the cryopumping in a novel way the cryopumping methods. The invention consists of a continuous operation cryopump, with movable louvres, with a high efficiency pumping apparatus. The pumping apparatus includes three cryogenic tubes. They are constructed of a substance of high thermal conductivity, such as aluminum and their exterior surfaces are cryogenic condensing surfaces. Through their interior liquid or gaseous helium from two reservoirs can be made to flow, alternately promoting extreme cooling or allowing some warming.

Batzer, T.H.; Call, W.R.

1984-12-04T23:59:59.000Z

222

Polymer flood filtration improvement  

Science Conference Proceedings (OSTI)

A process of recovery of hydrocarbons from a subterranean formation (wherein an aqueous liquid is injected into an injection well and hydrocarbons are produced from a production well, wherein at least a portion of the aqueous liquid is thickened with an organic polymer, and wherein an aqueous mixture containing the organic polymer is filtered prior to injection of the polymer) is affected by adding an amount of a surfactant to the aqueous mixture containing the polymer prior to filtration and sufficient to improve filterability. Filterability is further enhanced by addition of an ethoxylated alcohol surfactant and/or an alcohol. 6 claims.

Ferrell, H.H.; Conley, D.; Casad, B.M.; Stokke, O.M.

1980-07-15T23:59:59.000Z

223

Improved ion source  

DOE Patents (OSTI)

A magnetic filter for an ion source reduces the production of undesired ion species and improves the ion beam quality. High-energy ionizing electrons are confined by the magnetic filter to an ion source region, where the high-energy electrons ionize gas molecules. One embodiment of the magnetic filter uses permanent magnets oriented to establish a magnetic field transverse to the direction of travel of ions from the ion source region to the ion extraction region. In another embodiment, low energy 16 eV electrons are injected into the ion source to dissociate gas molecules and undesired ion species into desired ion species,

Leung, K.N.; Ehlers, K.W.

1982-05-04T23:59:59.000Z

224

Temperature differential detection device  

DOE Patents (OSTI)

A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions.

Girling, Peter M. (Allentown, PA)

1986-01-01T23:59:59.000Z

225

Temperature differential detection device  

DOE Patents (OSTI)

A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions. 2 figs.

Girling, P.M.

1986-04-22T23:59:59.000Z

226

Solar system fault detection  

SciTech Connect

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, Robert B. (Wheatridge, CO); Pruett, Jr., James C. (Lakewood, CO)

1986-01-01T23:59:59.000Z

227

Error detection method  

DOE Patents (OSTI)

An apparatus, program product, and method that run an algorithm on a hardware based processor, generate a hardware error as a result of running the algorithm, generate an algorithm output for the algorithm, compare the algorithm output to another output for the algorithm, and detect the hardware error from the comparison. The algorithm is designed to cause the hardware based processor to heat to a degree that increases the likelihood of hardware errors to manifest, and the hardware error is observable in the algorithm output. As such, electronic components may be sufficiently heated and/or sufficiently stressed to create better conditions for generating hardware errors, and the output of the algorithm may be compared at the end of the run to detect a hardware error that occurred anywhere during the run that may otherwise not be detected by traditional methodologies (e.g., due to cooling, insufficient heat and/or stress, etc.).

Olson, Eric J.

2013-06-11T23:59:59.000Z

228

Composition for detecting uranyl  

DOE Patents (OSTI)

The present invention relates to an indicator composition for use in spectrophotometric detection of a substance in a solution, and a method for making the composition. Useful indicators are sensitive to the particular substance being measured, but are unaffected by the fluid and other chemical species that may be present in the fluid. Optical indicators are used to measure the uranium concentration of process solutions in facilities for extracting uranium from ores, production of nuclear fuels, and reprocessing of irradiated fuels. The composition comprises an organohalide covalently bonded to an indicator for the substance, in such a manner that the product is itself an indicator that provides increased spectral resolution for detecting the substance. The indicator is preferably arsenazo III and the organohalide is preferably cyanuric chloride. These form a composition that is ideally suited for detecting uranyl.

Baylor, L.C.; Stephens, S.M.

1994-01-01T23:59:59.000Z

229

Solar system fault detection  

DOE Patents (OSTI)

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, R.B.; Pruett, J.C. Jr.

1984-05-14T23:59:59.000Z

230

NVLAP Radiation Detection Instruments LAP  

Science Conference Proceedings (OSTI)

Radiation Detection Instruments LAP. Leticia Pibida uses a hand-held radiation detection device to check cargo. Photo: Copyright Robert Rathe. ...

2013-07-23T23:59:59.000Z

231

Detection of solar events  

DOE Patents (OSTI)

A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

Fischbach, Ephraim; Jenkins, Jere

2013-08-27T23:59:59.000Z

232

Radiation detection system  

DOE Patents (OSTI)

A radiation detection system which utilizes the generation of Cerenkov light in and the transmission of that light longitudinally through fiber optic wave guides in order to transmit intelligence relating to the radiation to a remote location. The wave guides are aligned with respect to charged particle radiation so that the Cerenkov light, which is generated at an angle to the radiation, is accepted by the fiber for transmission therethrough. The Cerenkov radiation is detected, recorded, and analyzed at the other end of the fiber.

Nelson, Melvin A. (Santa Barbara, CA); Davies, Terence J. (Santa Barbara, CA); Morton, III, John R. (Livermore, CA)

1976-01-01T23:59:59.000Z

233

Proteomics for cancer biomarker discovery  

E-Print Network (OSTI)

Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...

Volchenboum, Samuel Louis

2007-01-01T23:59:59.000Z

234

Towards improved CZT crystals.  

Science Conference Proceedings (OSTI)

Past experimental efforts to improve CZT crystals for gamma spectrometer applications have been focused on reducing micron-scale defects such as tellurium inclusions and precipitates. While these micron-scale defects are important, experiments have shown that the micron-scale variations in transport can be caused by the formation and aggregation of atomic-scale defects such as dislocations and point defect clusters. Moreover, dislocation cells have been found to act as nucleation sites that cause the formation of large precipitates. To better solve the uniformity problem of CZT, atomic-scale defects must be understood and controlled. To this end, we have begun to develop an atomistic model that can be used to reveal the effects of small-scale defects and to guide experiments for reducing both atomic- and micron-scale (tellurium inclusions and precipitates) defects. Our model will be based upon a bond order potential (BOP) to enable large-scale molecular dynamics simulations of material structures at a high-fidelity level that was not possible with alternative methods. To establish how BOP improves over existing approaches, we report here our recent work on the assessment of two representative literature CdTe interatomic potentials that are currently widely used: the Stillinger-Weber (SW) potential and the Tersoff-Rockett (TR) potential. Careful examinations of phases, defects, and surfaces of the CdTe system were performed. We began our study by using both potentials to evaluate the lattice constants and cohesive energies of various Cd, Te, and CdTe phases including dimer, trimer, chain, square, rhomboid, tetrahedron, diamond-cubic (dc), simple-cubic (sc), body-centered-cubic (bcc), face-centered cubic (fcc), hexagonal-close-packed (hcp), graphite-sheet, A8, zinc-blende (zb), wurtzite (wz), NaCl, CsCl, etc. We then compared the results with our calculations using the density functional theory (DFT) quantum mechanical method. We also evaluated the suitability of the two potentials to predict the surface reconstructions and surface energies, various defect configurations and defect energies (interstitials and voids), elastic constants, and melting temperatures of different phases. We found that both potentials predicted incorrect energy trends as compared with those predicted by the DFT method. Most seriously, both potentials predicted incorrect lowest energy phases. These studies clearly showed that the existing potentials are not sufficient for correctly predicting the charge transport properties of CdTe demonstrating the need for a new potential. We anticipate that our BOP method will overcome this problem and will accelerate the discovery of a synthesis approach to produce improved CZT crystals.

Zimmerman, Jonathan A.; Ward, Donald K.; Doty, F. Patrick; Wong, Bryan Matthew; Zhou, Xiao Wang

2010-03-01T23:59:59.000Z

235

A region-based GLRT detection of oil spills in SAR images  

Science Conference Proceedings (OSTI)

In the study, we propose a fast region-based method for the detection of oil spills in SAR images. The proposed method combines the image segmentation technique and conventional detection theory to improve the accuracy of oil spills detection. From the ... Keywords: Constant false alarm ratio (CFAR), Generalizes likelihood ratio test (GLRT), Image segmentation, Oil spills, SAR image

Lena Chang; Z. S. Tang; S. H. Chang; Yang-Lang Chang

2008-10-01T23:59:59.000Z

236

Pulsing solenoid improvement  

Science Conference Proceedings (OSTI)

A control system improvement is disclosed. A high speed air bleed path and a low speed air bleed path respectively bleed air into the high speed and low speed fuel circuits of a carburetor through either fuel circuit at any one time. A solenoid responsive to a control signal opens and closes the air bleed to control the quantity of air bled into the high speed and low speed circuits. The solenoid includes an isolator for isolating the high speed air bleed path from the low speed air bleed path to prevent cross flow of air from one air bleed path to the other. Cross flow of air between the paths adversely affects the degree of control over the delivery of fuel through the high speed and low speed fuel circuits.

Tipton, L.J.

1982-02-09T23:59:59.000Z

237

Electronic ballast improves efficiency  

SciTech Connect

As part of a DOE program, the performance of various electronic ballasts for fluorescent lamps have been evaluated relative to high quality core-coil ballasts under similar ambient conditions. The results of this investigation are reported. Real energy savings can exceed 40% while comfort and quality of illumination are improved. A detailed comparison of two types of ballast is presented. Voltage effects and temperature effects as well as dimming features are discussed. Light levels, power energy consumption, and daylighting are also treated. It is concluded that, with the electronic ballast, an annual payback of $8.20/yr is possible as compared to the core-coil ballasted fluorescent lamp. Further, much greater flexibility in use is possible with the electronic ballast equipped lamp. (MJJ)

Verderber, R.R.

1980-11-01T23:59:59.000Z

238

Animal Models in Cancer Research  

Science Conference Proceedings (OSTI)

Cancer is a disorder that results in inappropriate growth of cells in the wrong place and at the wrong time. Most frequently cancer arises in older individuals and becomes problematic as it grows large enough to interrupt normal organ function, invades adjacent normal tissues disrupting their function, and spreads to other sites in the body, metastatic sites, where it causes further disabilities. Cancer arises in normal cells of our body. The environmental causes of cancer include numerous, disparate fac...

2009-12-17T23:59:59.000Z

239

Genetically engineered multivalent single chain antibody constructs for cancer therapy  

SciTech Connect

Current therapeutic approaches against the advanced stages of human solid tumors are palliative rather than curative. Many modalities, including, surgery, radiation, and chemotherapy, either alone or in combination have met with only modest success for advanced metastatic cancers. Radioimmunotherapy (RIT) combines the specificity of monoclonal antibodies with cytotxic effects of radioisotopes. It is the ?smart? way of delivering radiation to the known and occult metastatic cancer cells and is independent of drug toxicity and/or hormone resistance. The tumor associated glycoprotein-72 (TAG-72) containing the unique disaccharide sialyl-Tn, is highly expressed in majority of adenocarcinomas, including carcinomas of the prostate, breast, ovaries, pancreas and colon (80-90%) compared to undetectable expression in normal tissues. Monoclonal antibody CC49, reactive with TAG-72, after conjugation to potent gamma- and beta-emitting radionuclides, has been useful in selective systemic radiolocalization of disease and therapy of primary and metastatic tumor sites. However, limited therapeutic responses were observed in patients. Limited success of antibody based delivery of radioisotopes can be attributed to several factors including undesirable pharmacokinetics, poor tumor uptake and high immunogenicity of intact antibodies (IgGs). The primary factors contributing towards the failure of RIT include: 1) longer serum half-lives of the intact IgG molecules resulting in the radiotoxicity, 2) generation of human antibodies against murine antibodies (HAMA) that limits the frequency of dose administration, 3) poor diffusion rates of intact IgG due to the large size and 4) high interstitial fluid pressures (IFP) encountered in solid tumors. The major goal of our multidisciplinary project was to develop specific novel radiopharmaceuticals, with desired pharmacokinetics, for the diagnosis and therapy of solid tumors. To overcome the low uptake of radioactivity by tumors and to increase its tumor: normal tissue ratio for improved therapeutic index, we engineered a variety antibody constructs. These constructs were evaluated using novel approaches like special radionuclides, pretargeting and optimization. Due to the smaller size, the engineered antibody molecules should penetrate better throughout a tumor mass, with less dose heterogeneity, than is the case with intact IgG. Multivalent scFvs with an appropriate radionuclide, therefore, hold promising prospects for cancer therapy and clinical imaging in MAb-based radiopharmaceuticals. In addition, the human anti-mouse antibodies (HAMA) responses in patients against antibody-based therapy are usually directed against the immunoglobulin constant regions; however, anti-idiotypic responses can also be detected. The HAMA responses reduce the efficacy of treatment by removing the circulating antibody molecules, fragments, and possibly scFvs by altering the pharmacokinetic properties of the antibody. HAMA responses against divalent IgG, divalent Ig fragments, and possibly multimeric scFvs could cause immune complex formation with hypersensitivity or allergic reactions that could be harmful to patients. The use of small molecules, such as scFvs (monomeric as well as multimeric), with their shorter biological half-lives and the lack of the constant regions and humanized variable (binding regions) performed in our studies should reduce the development of HAMA. The generation of humanized and fully human scFvs should further reduce the development of HAMA. Specific accomplishments on the project are the production of large amounts of recombinant antibodies as they are required in large amounts for cancer diagnosis and therapy. A variety of single-chain Fv (scFv) constructs were engineered for the desired pharmacokinetic properties. Tetrameric and dimeric scFvs showed a two-fold advantage: (1) there was a considerable gain in avidity as compared to smaller fragments, and (2) the biological half-life was more compatible with RIT and RIS requirements. For RIT, delivery for sc(Fv)2 and [sc(Fv)2]2 in a fr

Surinder Batra, Ph.D.

2006-02-27T23:59:59.000Z

240

Improved steamflood analytical model  

E-Print Network (OSTI)

The Jeff Jones steamflood model incorporates oil displacement by steam as described by Myhill and Stegemeier, and a three-component capture factor based on empirical correlations. The main drawback of the model however is the unsatisfactory prediction of the oil production peak: usually significantly lower than the actual. Our study focuses on improving this aspect of the Jeff Jones model. In our study, we simulated the production performance of a 5-spot steamflood pattern unit and compared the results against those based on the Jeff Jones model. Three reservoir types were simulated using 3-D Cartesian black oil models: Hamaca (9�°API), San Ardo (12�°API) and that based on the SPE fourth comparative solution project (14�°API). In the first two field cases, a 45x23x8 model was used that represented 1/8 of a 10-acre 5-spot pattern unit, using typical rock and reservoir fluid properties. In the SPE project case, three models were used: 23x12x12 (2.5 ac), 31x16x12 (5 ac) and 45x23x8 (10 ac), that represented 1/8 of a 5-spot pattern unit. To obtain a satisfactory match between simulation and Jeff Jones analytical model results of the start and height of the production peak, the following refinements to the Jeff Jones model were necessary. First, the dimensionless steam zone size AcD was modified to account for decrease in oil viscosity during steamflood and its dependence on the steam injection rate. Second, the dimensionless volume of displaced oil produced VoD was modified from its square-root format to an exponential form. The modified model gave very satisfactory results for production performance up to 20 years of simulated steamflood, compared to the original Jeff Jones model. Engineers will find the modified model an improved and useful tool for prediction of steamflood production performance.

Chandra, Suandy

2005-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Maintenance Work Management Improvement: Improving Culture and Work Process  

Science Conference Proceedings (OSTI)

EPRI's Plant Maintenance Optimization (PMO) mission is to develop and demonstrate products and services for improved use of power plant maintenance resources and increased profitability. Based on a series of work management improvement projects, EPRI plans to develop a best practices guideline. As part of this effort, this document details how to improve fossil power plant work culture and work processes.

1998-06-16T23:59:59.000Z

242

Detection of counterfeit currency  

DOE Patents (OSTI)

A method is disclosed of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1,250 nanometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency. 18 figs.

Burns, D.A.

1998-05-26T23:59:59.000Z

243

DETECTION OR WARNING SYSTEM  

DOE Patents (OSTI)

This patent application describes a sensitive detection or protective system capable of giving an alarm or warning upon the entrance or intrusion of any body into a defined area or zone protected by a radiation field of suitable direction or extent.

Tillman, J.E.

1951-06-30T23:59:59.000Z

244

Toward gravitational wave detection  

E-Print Network (OSTI)

An overview of some tools and techniques being developed for data conditioning (regression of instrumental and environmental artifacts from the data channel), detector design evaluation (modeling the science ``reach'' of alternative detector designs and configurations), noise simulations for mock data challenges and analysis system validation, and analyses for the detection of gravitational radiation from gamma-ray burst sources.

L. S. Finn; G. Gonzalez; J. Hough; M. F. Huq; S. Mohanty; J. Romano; S. Rowan; P. R. Saulson; K. A. Strain

1999-11-02T23:59:59.000Z

245

Wikipedia vandalism detection  

Science Conference Proceedings (OSTI)

Wikipedia is an online encyclopedia that anyone can access and edit. It has become one of the most important sources of knowledge online and many third party projects rely on it for a wide-range of purposes. The open model of Wikipedia allows pranksters, ... Keywords: Wikipedia vandalism detection, machine learning, natural language processing, reputation

Santiago M. Mola-Velasco

2011-03-01T23:59:59.000Z

246

Radiation Detection from Fission  

SciTech Connect

This report briefly describes the neutrons and gamma rays emitted in fission, briefly discusses measurement methods, briefly discusses sources and detectors relevant to detection of shielded HEU in sealand containers, and lists the measurement possibilities for the various sources. The brief descriptions are supplemented by reference.

Mihalczo, J.

2004-11-17T23:59:59.000Z

247

Radiation detection system  

SciTech Connect

A radiation detection system including a radiation-to-light converter and fiber optic wave guides to transmit the light to a remote location for processing. The system utilizes fluors particularly developed for use with optical fibers emitting at wavelengths greater than about 500 nm and having decay times less than about 10 ns.

Franks, Larry A. (Santa Barbara, CA); Lutz, Stephen S. (Santa Barbara, CA); Lyons, Peter B. (Los Alamos, NM)

1981-01-01T23:59:59.000Z

248

Initiative for Explosives Detection  

E-Print Network (OSTI)

capabilities. Staff at PNNL are developing effective integrated systems for explosives detection, addressing, fundamental science and health. Battelle, based in Columbus, Ohio, has operated PNNL since 1965. PNNL's long. PNNL is located in Richland, Washington. Additional web resources are at: http

249

The ACGT Master Ontology and its applications - Towards an ontology-driven cancer research and management system  

Science Conference Proceedings (OSTI)

Objective: This paper introduces the objectives, methods and results of ontology development in the EU co-funded project Advancing Clinico-genomic Trials on Cancer - Open Grid Services for Improving Medical Knowledge Discovery (ACGT). While the available ... Keywords: Cancer research, Clinical trial administration, Ontological engineering, Ontology, Translational medicine

Mathias Brochhausen; Andrew D. Spear; Cristian Cocos; Gabriele Weiler; Luis Martín; Alberto Anguita; Holger Stenzhorn; Evangelia Daskalaki; Fatima Schera; Ulf Schwarz; Stelios Sfakianakis; Stephan Kiefer; Martin Dörr; Norbert Graf; Manolis Tsiknakis

2011-02-01T23:59:59.000Z

250

Roadway Improvement Project Cost Allocation  

E-Print Network (OSTI)

Roadway Improvement Project Cost Allocation CTS 21st Annual Transportation Research Conference costs #12;Potential Applications · Roadway Project Feasibility Studies ­ Identified potential roadway infrastructure improvement ­ Documentation of estimated project costs ­ Determine property assessments

Minnesota, University of

251

Refines Efficiency Improvement  

Science Conference Proceedings (OSTI)

Refinery processes that convert heavy oils to lighter distillate fuels require heating for distillation, hydrogen addition or carbon rejection (coking). Efficiency is limited by the formation of insoluble carbon-rich coke deposits. Heat exchangers and other refinery units must be shut down for mechanical coke removal, resulting in a significant loss of output and revenue. When a residuum is heated above the temperature at which pyrolysis occurs (340 C, 650 F), there is typically an induction period before coke formation begins (Magaril and Aksenova 1968, Wiehe 1993). To avoid fouling, refiners often stop heating a residuum before coke formation begins, using arbitrary criteria. In many cases, this heating is stopped sooner than need be, resulting in less than maximum product yield. Western Research Institute (WRI) has developed innovative Coking Index concepts (patent pending) which can be used for process control by refiners to heat residua to the threshold, but not beyond the point at which coke formation begins when petroleum residua materials are heated at pyrolysis temperatures (Schabron et al. 2001). The development of this universal predictor solves a long standing problem in petroleum refining. These Coking Indexes have great potential value in improving the efficiency of distillation processes. The Coking Indexes were found to apply to residua in a universal manner, and the theoretical basis for the indexes has been established (Schabron et al. 2001a, 2001b, 2001c). For the first time, a few simple measurements indicates how close undesired coke formation is on the coke formation induction time line. The Coking Indexes can lead to new process controls that can improve refinery distillation efficiency by several percentage points. Petroleum residua consist of an ordered continuum of solvated polar materials usually referred to as asphaltenes dispersed in a lower polarity solvent phase held together by intermediate polarity materials usually referred to as resins. The Coking Indexes focus on the amount of these intermediate polarity species since coke formation begins when these are depleted. Currently the Coking Indexes are determined by either titration or solubility measurements which must be performed in a laboratory. In the current work, various spectral, microscopic, and thermal techniques possibly leading to on-line analysis were explored for measuring the Coking Indexes.

WRI

2002-05-15T23:59:59.000Z

252

NETL: Power Plant Improvement Initiative  

NLE Websites -- All DOE Office Websites (Extended Search)

Project Performance Summaries Power Plant Improvement Initiative (PPII) Project Performance Summaries Project Performance Summaries are written after project completion. These...

253

Market Incentives to Improve Cybersecurity  

Science Conference Proceedings (OSTI)

Page 1. Market Incentives to Improve Cybersecurity Herb Lin ... threaten critical societal functions. • Regulation that imposes best practices on system ...

2011-07-20T23:59:59.000Z

254

Lake Improvement District Law and County Lake Improvement Program  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Lake Improvement District Law and County Lake Improvement Program Lake Improvement District Law and County Lake Improvement Program (Minnesota) Lake Improvement District Law and County Lake Improvement Program (Minnesota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Minnesota Program Type Siting and Permitting Lake Improvement Districts may be established by county boards in order to

255

Managing Energy Efficiency Improvement  

E-Print Network (OSTI)

In 1991, the World Business Council for Sustainable Development (WBCSD) introduced “Eco- Efficiency” as a management strategy to link financial and environmental performance to create more value with less ecological impact. Based on this strategy, CETAC-WEST (Canadian Environmental Technology Advancement Corporation - West), in mid-2000, introduced a practical approach to eco-efficiency to Western Canada's upstream oil and gas sector. The CETAC-WEST Eco-Efficiency Program, focused primarily on sour gas processing facilities, has developed methods and programs to identify opportunities for energy conservation and GHG reductions. The program outlined in this paper consists of four interrelated phases that are used to identify and track efficiency opportunities as well as promote the use of energy efficient methodologies and technologies. If, as program results suggest, 15% to 20% of the gas that is now consumed at by plant operations can be saved through efficiencies, it would save $500 to $700 million worth of gas for sale on the market. Although this small Pilot Program in the gas processing sector has surfaced major opportunities, there are significantly greater opportunities in other sectors with high GHG emissions intensity, such as sweet gas processing, conventional oil, heavy oil and oil sands. Capturing these opportunities will require a carefully considered strategy. This strategy should include, in addition to commitments for expanding the scope of the current Program, sustained leadership by industry champions and by governments - all aimed at changing the operating mode and improving the culture in the oil and gas industry.

Almaguer, J.

2006-01-01T23:59:59.000Z

256

IMPROVED BONDING METHOD  

DOE Patents (OSTI)

An improved process of bonding aluminum to aluminum without fusion by ultrasonic vibrations plus pressure is described. The surfaces to be bonded are coated with an aqueous solution of alkali metal stearate prior to assembling for bonding. (AEC) O H19504 Present information is reviewed on steady state proliferation, differentiation, and maturation of blood cells in mammals. Data are cited from metabolic tracer studies, autoradiographic studies, cytologic studies, studies of hematopoietic response to radiation injuries, and computer analyses of blood cell production. A 3-step model for erythropoiesis and a model for granulocyte kinetics are presented. New approaches to the study of lymphocytopoiesis described include extracorporeal blood irradiation to deplete lymphocytic tissue without direct injury to the formative tissues as a means to study the stressed system, function control, and rates of proliferation. It is pointed out that present knowledge indicates that lymphocytes comprise a mixed family, with diverse life spans, functions, and migration patterns with apparent aimless recycling from modes to lymph to blood to nodes that has not yet been quantitated. Areas of future research are postulated. (70 references.) (C.H.)

Padgett, E.V. Jr.; Warf, D.H.

1964-04-28T23:59:59.000Z

257

Protein detection system  

DOE Patents (OSTI)

The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.

Fruetel, Julie A. (Livermore, CA); Fiechtner, Gregory J. (Bethesda, MD); Kliner, Dahv A. V. (San Ramon, CA); McIlroy, Andrew (Livermore, CA)

2009-05-05T23:59:59.000Z

258

Solar neutrino detection  

SciTech Connect

More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

Miramonti, Lino [Physics department of Milano University and INFN (Italy)

2009-04-30T23:59:59.000Z

259

Cell Phone Detection Techniques  

Science Conference Proceedings (OSTI)

A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phone’s electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

2007-10-01T23:59:59.000Z

260

Solar neutrino detection  

E-Print Network (OSTI)

More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

Lino Miramonti

2009-01-22T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Detection of pump degradation  

SciTech Connect

This Phase II Nuclear Plant Aging Research study examines the methods of detecting pump degradation that are currently employed in domestic and overseas nuclear facilities. This report evaluates the criteria mandated by required pump testing at U.S. nuclear power plants and compares them to those features characteristic of state-of-the-art diagnostic programs and practices currently implemented by other major industries. Since the working condition of the pump driver is crucial to pump operability, a brief review of new applications of motor diagnostics is provided that highlights recent developments in this technology. The routine collection and analysis of spectral data is superior to all other technologies in its ability to accurately detect numerous types and causes of pump degradation. Existing ASME Code testing criteria do not require the evaluation of pump vibration spectra but instead overall vibration amplitude. The mechanical information discernible from vibration amplitude analysis is limited, and several cases of pump failure were not detected in their early stages by vibration monitoring. Since spectral analysis can provide a wealth of pertinent information concerning the mechanical condition of rotating machinery, its incorporation into ASME testing criteria could merit a relaxation in the monthly-to-quarterly testing schedules that seek to verify and assure pump operability. Pump drivers are not included in the current battery of testing. Operational problems thought to be caused by pump degradation were found to be the result of motor degradation. Recent advances in nonintrusive monitoring techniques have made motor diagnostics a viable technology for assessing motor operability. Motor current/power analysis can detect rotor bar degradation and ascertain ranges of hydraulically unstable operation for a particular pump and motor set. The concept of using motor current or power fluctuations as an indicator of pump hydraulic load stability is presented.

Greene, R.H.; Casada, D.A.; Ayers, C.W. [and others

1995-08-01T23:59:59.000Z

262

Chromosome-specific staining to detect genetic rearrangements  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W.; Pinkel, Daniel; Tkachuk, Douglas; Westbrook, Carol

2013-04-09T23:59:59.000Z

263

Method of detecting genetic deletions identified with chromosomal abnormalities  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acids probes are typically of a complexity greater tha 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particlularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar ut genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W; Pinkel, Daniel; Tkachuk, Douglas

2013-11-26T23:59:59.000Z

264

Method of detecting genetic translocations identified with chromosomal abnormalities  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Tkachuk, Douglas (Livermore, CA)

2001-01-01T23:59:59.000Z

265

Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery and Radiotherapy for Early Breast Cancer: Results From a Large Series With Long-Term Follow-Up  

SciTech Connect

Purpose: To investigate conventional prognostic factors for ipsilateral breast tumor recurrence (IBTR), distant metastasis (DM), and survival after breast-conserving therapy (BCT) in screen-detected and symptomatic cases on surveillance up to 25 years. Patients and Methods: A total of 1812 consecutive patients in three cohorts (1981-1989, 1990-1992, and 1993-1998) with T12N01M0 invasive breast cancer were treated with BCT (median follow-up, 14 years). Tumor type and grade were reviewed by a single pathologist. Hormone receptor status was measured by immunohistochemistry on tissue microarrays. A Cox proportional hazards model was used to assess independent prognostic variables for relapse and survival. Results: A total of 205 IBTR occurred, with 5-, 10-, 15-, and 20-year actuarial relapse rates of 4.5% (95% confidence interval [CI] 3.35-5.5%), 8.4% (95% CI 7.1-9.8%), 14.1% (95% CI 12.0-16%), and 17.4% (95% CI 14.5-20.2%). Number of nodes, young age, pathologic tumor size, and multifocality were significant factors for IBTR. Three hundred seventy-eight patients developed DM. The actuarial metastatic rate was 12% at 5 years and 17.9% at 10 years. Young age, number of positive nodes, pathologic tumor size, and tumor grade were significant factors for DM relapse. When conventional prognostic indices were taken into account screen-detected cancers showed no improvement in overall relapse or survival rate compared with symptomatic cases but did show a reduced risk of DM after IBTR. After 10 years IBTR relapse continued at a constant rate of 0.87% per annum. Conclusions: The Edinburgh BCT series has shown that screen-detected invasive breast cancers do not have significantly different clinical outcomes compared with symptomatic cases when pathologic risk factors are taken into account. This suggests that these patients be managed in a similar way.

Kunkler, Ian H., E-mail: I.Kunkler@ed.ac.uk [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Kerr, Gillian R. [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Thomas, Jeremy S. [Department of Pathology, Western General Hospital, Edinburgh (United Kingdom); Jack, Wilma J.L. [Edinburgh Breast Unit, Western General Hospital, Edinburgh (United Kingdom); Bartlett, John M.S. [Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh (United Kingdom); Pedersen, Hans C. [DAKO (Denmark); Cameron, David A. [Edinburgh Cancer Centre, Western General Hospital, Edinburgh (United Kingdom); Dixon, J. Michael; Chetty, Udi [Edinburgh Breast Unit, Western General Hospital, Edinburgh (United Kingdom)

2012-07-01T23:59:59.000Z

266

Remote detection of fissile material : Cherenkov counters for gamma detection  

E-Print Network (OSTI)

The need for large-size detectors for long-range active interrogation (Al) detection has generated interest in water-based detector technologies. AI is done using external radiation sources to induce fission and to detect, ...

Erickson, Anna S

2011-01-01T23:59:59.000Z

267

Monte Carlo Simulations for Mine Detection  

DOE Green Energy (OSTI)

During January, 1998, collaboration between LLNL, UCI and Exdet, Ltd. arranged for the testing and evaluation of a Russian developed antitank mine detection system at the Buried Objects Detection Facility (BODF) located at the Nevada Test Site. BODF is a secured 30-acre facility with approximately 300 live antitank mines that were buried in 1993 and 1994. The burial depths range from a few cm to 15 cm and the various metal- and plastic-case antitank mines each contain 6-12 kg of high explosive. Contractors who have tested their mine detection equipment at BODF include: SAIC, SRI, ERIM, MIT/Lincoln Laboratory and Loral Defense Systems. In addition LLNL researchers have used BODF to test antitank mine detection systems based on: dual-band infrared imaging, hyper-spectral imaging, synthetic aperture impulse radar and micro-impulse radar. In a blind test the Russian operated system obtained the highest score of any technology tested to date at BODF. The system is based on combining information from two separate sensors; one to detect anomalous concentrations of hydrogen and the other to detect if such anomalies also have the correct nitrogen to carbon ratio for high explosives. The detection sensitivity is set by the geometry and type of neutron moderator and filters surrounding the neutron source and detectors. Detection of hydrogen anomalies is a rapid process based on neutron scattering. The handheld instrument on the end of a wand could scan a large area at a rate of 4-5 square meters per minute. Once the hydrogen anomalies were located a second sensor was used to measure the thermal neutron excited gamma-ray spectrum at each hydrogen anomaly to determine whether that location in addition contained high concentrations of nitrogen. The second process was slower, taking up to 5 minutes for each location. The information from both sensors were then examined by the operator and a declaration was made as to whether or not the anomaly was a buried antitank mine. Although the system worked extremely well on all classes of anti-tank mines, the Russian hardware components were inferior to those that are commercially available in the United States, i.e. the NaI(Tl) crystals had significantly higher background levels and poorer resolution than their U.S. counterparts, the electronics appeared to be decades old and the photomultiplier tubes were noisy and lacked gain stabilization circuitry. During the evaluation of this technology, the question that came to mind was: could state-of-the-art sensors and electronics and improved software algorithms lead to a neutron based system that could reliably detect much smaller buried mines; namely antipersonnel mines containing 30-40 grams of high explosive? Our goal in this study was to conduct Monte Carlo simulations to gain better understanding of both phases of the mine detection system and to develop an understanding for the system's overall capabilities and limitations. In addition, we examined possible extensions of this technology to see whether or not state-of-the-art improvements could lead to a reliable anti-personnel mine detection system.

Toor, A.; Marchetti, A.A.

2000-03-14T23:59:59.000Z

268

Nucleic acid detection compositions  

DOE Patents (OSTI)

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Madison, WI); Lyamichev, Victor I. (Madison, WI); Brow, Mary Ann (Madison, WI); Dahlberg, James L. (Madison, WI)

2008-08-05T23:59:59.000Z

269

HRT LEAK DETECTION SYSTEM  

SciTech Connect

All HRT process piping and equipment is contained in a large tank and flanged connections with stainless steel ring gaskets are used where needed to permit the removal of values and items of equipment. Underwater remote maintenance is to be employed and special provisions are required for indicating and locating leaks at all mechanical joints in the process system. Each joint is monitored and a signal is given when a leak occurs. The valve operator stems are sealed with stainless steel bellows and a means of detecting a leak in the bellows has been included. (auth)

Kuster, J.E.

1956-04-20T23:59:59.000Z

270

Flaw detection and evaluation  

DOE Patents (OSTI)

The invention provides a method of and apparatus for optically inspecting nuclear fuel pellets for surface flaws. The inspection system includes a prism and lens arrangement for scanning the surface of each pellet as the same is rotated. The resulting scan produces data indicative of the extent and shape of each flaw which is employed to generate a flaw quality index for each detected flaw. The flaw quality indexes from all flaws are summed and compared with an acceptable surface quality index. The result of the comparison is utilized to control the acceptance or rejection of the pellet.

Wilks, Robert S. (Plum, PA); Sturges, Jr., Robert H. (Plum, PA)

1983-01-01T23:59:59.000Z

271

Outlier Detection Rules for Fault Detection in Solar Photovoltaic Arrays  

E-Print Network (OSTI)

fault detection. Furthermore, the proposed models become more reliable as the number of PV measurements analysis specifically for PV installation. Several fault detection models and monitoring systems have been studied for PV systems [8]­[14]. PV monitoring and fault detection models based on energy yield and power

Lehman, Brad

272

Development, Implementation, and Testing of Fault Detection Strategies on the National Wind Technology Center's Controls Advanced Research Turbines  

Science Conference Proceedings (OSTI)

The National Renewable Energy Laboratory's National Wind Technology Center dedicates two 600 kW turbines for advanced control systems research. A fault detection system for both turbines has been developed, analyzed, and improved across years of experiments to protect the turbines as each new controller is tested. Analysis of field data and ongoing fault detection strategy improvements have resulted in a system of sensors, fault definitions, and detection strategies that have thus far been effective at protecting the turbines. In this paper, we document this fault detection system and provide field data illustrating its operation while detecting a range of failures. In some cases, we discuss the refinement process over time as fault detection strategies were improved. The purpose of this article is to share field experience obtained during the development and field testing of the existing fault detection system, and to offer a possible baseline for comparison with more advanced turbine fault detection controllers.

Johnson, K. E.; Fleming, P. A.

2011-06-01T23:59:59.000Z

273

Nanolubricants to Improve Chiller Performance  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Nanolubricants to Improve Chiller Nanolubricants to Improve Chiller Performance Mark Kedzierski NIST MAK@NIST.GOV 301 975 5282 April 3, 2013 2 | Building Technologies Office eere.energy.gov Purpose & Objectives Problem Statement: Enabling technology for improving the efficiency of chillers that cool large buildings with nanolubricants. (Nanolubricants are not currently used in chillers.) Develop fundamental understanding of how nanolubricants enhance refrigerant/nanolubricant. What nanoparticle size,

274

Technology Deployment Matrix Improvements - Updates  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory September 15, 2011 2 | Interagency Technology Deployment Working Group eere.energy.gov Technology Deployment Matrix Improvement Efforts 1. Develop criteria for...

275

Improve energy performance | ENERGY STAR  

NLE Websites -- All DOE Office Websites (Extended Search)

track, and benchmark Improve energy performance ENERGY STAR industrial partnership Energy guides Energy efficiency and air regulation Plant energy auditing Industrial...

276

Improved MK42 Melting Model  

Science Conference Proceedings (OSTI)

An improved Mark 42 melting model has been defined for establishing confinement protection limits (CPLs). This report describes the new melting model and its application in computing CPLs.

Tudor, A.A.

2001-09-19T23:59:59.000Z

277

NETL: Turbine Projects - Efficiency Improvement  

NLE Websites -- All DOE Office Websites (Extended Search)

Efficiency Improvemenet Turbine Projects Efficiency Improvemenet Advanced Hot Section Materials and Coatings Test Rig DataFact Sheets System Study for Improved Gas Turbine...

278

Collision detection and proximity queries  

Science Conference Proceedings (OSTI)

This course will primarily cover widely accepted and proved methodologies in collision detection. In addition more advanced or recent topics such as continuous collision detection, ADFs, and using graphics hardware will be introduced. When appropriate ...

Sunil Hadap; Dave Eberle; Pascal Volino; Ming C. Lin; Stephane Redon; Christer Ericson

2004-08-01T23:59:59.000Z

279

Microburst Detection Using Agent Networks  

Science Conference Proceedings (OSTI)

Automatic detection of microbursts with Doppler radar data is an interesting challenge. Traditionally, manual detection is performed by trained meteorologists who scan through the volumetric radar data for appropriate signatures, bringing to bear ...

Sandy Dance; Rodney Potts

2002-05-01T23:59:59.000Z

280

Detecting alien life forms  

NLE Websites -- All DOE Office Websites (Extended Search)

Detecting alien life forms Detecting alien life forms Name: Brian S Foster Status: N/A Age: N/A Location: N/A Country: N/A Date: N/A Question: What would you do to find out if there is any life form on other planets? Replies: If you mean intelligent life, probably the best way would be to listen for radio messages, since you could do this from very far away. Earth emits as much radio energy as a small star --- very noticeable. If you mean just any kind of life it gets harder and you would have to send a robot or human in a spacecraft to visit. You could then look for the absorption of reflected light by oxygen molecules in the atmosphere. Oxygen is such a reactive molecule that it can only stay in the atmosphere if it is continually replenished by something, such as plants photosynthesizing. We cannot of course know that other life will build itself as does life on Earth, out of carbon-containing molecules which are formed by cracking apart carbon dioxide molecules with light energy (releasing oxygen). So the only sure way would probably be to land on the planet and look around. And even then you might well miss something

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Dynamic Fault Detection Chassis  

Science Conference Proceedings (OSTI)

Abstract The high frequency switching megawatt-class High Voltage Converter Modulator (HVCM) developed by Los Alamos National Laboratory for the Oak Ridge National Laboratory's Spallation Neutron Source (SNS) is now in operation. One of the major problems with the modulator systems is shoot-thru conditions that can occur in a IGBTs H-bridge topology resulting in large fault currents and device failure in a few microseconds. The Dynamic Fault Detection Chassis (DFDC) is a fault monitoring system; it monitors transformer flux saturation using a window comparator and dV/dt events on the cathode voltage caused by any abnormality such as capacitor breakdown, transformer primary turns shorts, or dielectric breakdown between the transformer primary and secondary. If faults are detected, the DFDC will inhibit the IGBT gate drives and shut the system down, significantly reducing the possibility of a shoot-thru condition or other equipment damaging events. In this paper, we will present system integration considerations, performance characteristics of the DFDC, and discuss its ability to significantly reduce costly down time for the entire facility.

Mize, Jeffery J [ORNL

2007-01-01T23:59:59.000Z

282

Radiation Detection with Plastic Scintillators  

Environmental information. ... As well as help in detecting neutrons in major scientific projects. ... for the Department of Energy's National Nuclear ...

283

Ultrahigh Energy Cosmic Rays Detection  

Science Conference Proceedings (OSTI)

The paper describes methods used for the detection of cosmic rays with energies above 1018 eV (UHECR

Carla Aramo

2005-01-01T23:59:59.000Z

284

UNICORN: misuse detection for UNICOS  

Science Conference Proceedings (OSTI)

An effective method for detecting computer misuse is the automatic auditing and analysis of on-line user activity. This activity is reflected in the system audit record, by changes in the vulnerability posture of the system configuration, and in other ... Keywords: anomaly detection, computer misuse, auditing, UNICOS, computer security, hacking, intrusion detection, security logs

Gary G. Christoph; Kathleen A. Jackson; Michael C. Neuman; Christine L. B. Siciliano; Dennis D. Simmonds; Cathy A. Stallings; Joseph L. Thompson

1995-12-01T23:59:59.000Z

285

An Intrusion-Detection Model  

Science Conference Proceedings (OSTI)

A model of a real-time intrusion-detection expert system capable of detecting break-ins, penetrations, and other forms of computer abuse is described. The model is based on the hypothesis that security violations can be detected by monitoring a system's ... Keywords: statistical measures, Abnormal behavior, auditing, intrusions, monitoring, profiles, security

Dorothy E. Denning

1987-02-01T23:59:59.000Z

286

Monitoring smartphones for anomaly detection  

Science Conference Proceedings (OSTI)

In this paper we demonstrate how to monitor a smartphone running Symbian operating system and Windows Mobile in order to extract features for anomaly detection. These features are sent to a remote server because running a complex intrusion detection ... Keywords: anomaly detection, monitoring, smartphones

Aubrey-Derrick Schmidt; Frank Peters; Florian Lamour; Christian Scheel; Seyit Ahmet Çamtepe; Sahin Albayrak

2009-02-01T23:59:59.000Z

287

Sensitivity enhancement of SPR biosensor by improving surface quality of glass slides  

Science Conference Proceedings (OSTI)

Surface plasmon resonance (SPR) is one of the most sensitive label-free detection methods and has been applied in a wide range of chemical and biological sensing. Sensitivity enhancement of metal coated sensor chips is necessary for improving the detection ... Keywords: Sensitivity, Surface plasmon resonance, Surface roughness

X. Chen; M. Pan; K. Jiang

2010-05-01T23:59:59.000Z

288

Improving the accuracy of the optimum-path forest supervised classifier for large datasets  

Science Conference Proceedings (OSTI)

In this work, a new approach for supervised pattern recognition is presented which improves the learning algorithm of the Optimum-Path Forest classifier (OPF), centered on detection and elimination of outliers in the training set. Identification of outliers ... Keywords: learning algorithm, optimum-path forest classifier, outlier detection, supervised classification

César Castelo-Fernández; Pedro J. De Rezende; Alexandre X. Falcão; João Paulo Papa

2010-11-01T23:59:59.000Z

289

Automatic Detection of Unsafe Component Loadings  

E-Print Network (OSTI)

Dynamic loading of software components (e.g., libraries or modules) is a widely used mechanism for improved system modularity and flexibility. Correct component resolution is critical for reliable and secure software execution, however, programming mistakes may lead to unintended or even malicious components to be resolved and loaded. In particular, dynamic loading can be hijacked by placing an arbitrary file with the specified name in a directory searched before resolving the target component. Although this issue has been known for quite some time, it was not considered serious because exploiting it requires access to the local file system on the vulnerable host. Recently such vulnerabilities started to receive considerable attention as their remote exploitation became realistic; it is now important to detect and fix these vulnerabilities. In this paper, we present the first automated technique to detect vulnerable and unsafe dynamic component loadings. Our analysis has two phases: 1) apply dynamic binary instrumentation to collect runtime information on component loading (online phase); and 2) analyze the collected information to detect vulnerable component loadings (offline phase). For evaluation, we implemented our technique to detect vulnerable and unsafe DLL loadings in popular Microsoft Windows software. Our results show that unsafe DLL loading is prevalent and can lead to serious security threats. Our tool detected more than 1,700 unsafe DLL loadings in 28 widely used software and discovered serious attack vectors for remote code execution. Microsoft has opened a Microsoft Security Response Center (MSRC) case on our reported issues and is working with us and other affected software vendors to develop necessary patches.

Taeho Kwon; Zhendong Su

2010-01-01T23:59:59.000Z

290

Arc fault detection system  

DOE Patents (OSTI)

An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard.

Jha, Kamal N. (Bethel Park, PA)

1999-01-01T23:59:59.000Z

291

RADIATION WAVE DETECTION  

DOE Patents (OSTI)

Radiation waves can be detected by simultaneously measuring radiation- wave intensities at a plurality of space-distributed points and producing therefrom a plot of the wave intensity as a function of time. To this end. a detector system is provided which includes a plurality of nuclear radiation intensity detectors spaced at equal radial increments of distance from a source of nuclear radiation. Means are provided to simultaneously sensitize the detectors at the instant a wave of radiation traverses their positions. the detectors producing electrical pulses indicative of wave intensity. The system further includes means for delaying the pulses from the detectors by amounts proportional to the distance of the detectors from the source to provide an indication of radiation-wave intensity as a function of time.

Wouters, L.F.

1960-08-30T23:59:59.000Z

292

Arc fault detection system  

DOE Patents (OSTI)

An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard. 1 fig.

Jha, K.N.

1999-05-18T23:59:59.000Z

293

Detection of gas leakage  

DOE Patents (OSTI)

A method of detecting leaks and measuring volumes as well as an apparatus, the Power-free Pump Module (PPM), that is a self-contained leak test and volume measurement apparatus that requires no external sources of electrical power during leak testing or volume measurement, where the invention is a portable, pneumatically-controlled instrument capable of generating a vacuum, calibrating volumes, and performing quantitative leak tests on a closed test system or device, all without the use of alternating current (AC) power. Capabilities include the ability is to provide a modest vacuum (less than 10 Torr), perform a pressure rise leak test, measure the gas's absolute pressure, and perform volume measurements. All operations are performed through a simple rotary control valve which controls pneumatically-operated manifold valves.

Thornberg, Steven (Peralta, NM); Brown, Jason (Albuquerque, NM)

2012-06-19T23:59:59.000Z

294

Weld failure detection  

DOE Patents (OSTI)

Method and apparatus for detecting failure in a welded connection, particrly applicable to not readily accessible welds such as those joining components within the reactor vessel of a nuclear reactor system. A preselected tag gas is sealed within a chamber which extends through selected portions of the base metal and weld deposit. In the event of a failure, such as development of a crack extending from the chamber to an outer surface, the tag gas is released. The environment about the welded area is directed to an analyzer which, in the event of presence of the tag gas, evidences the failure. A trigger gas can be included with the tag gas to actuate the analyzer.

Pennell, William E. (Unity Township, Westmoreland County, PA); Sutton, Jr., Harry G. (Mt. Lebanon, PA)

1981-01-01T23:59:59.000Z

295

New Light on Improving Engine Efficiencies | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

The Crystal Structure of a Meta-stable Intermediate Particle in Virus The Crystal Structure of a Meta-stable Intermediate Particle in Virus Assembly Increasing Magnetic Response of Ferromagnetic Semiconductors under High Pressure Better Switching Through Chemistry in Thin Ferroelectrics First Molecular-Level Enzyme Images Could Improve Breast-Cancer Therapy Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed New Light on Improving Engine Efficiencies MARCH 3, 2009 Bookmark and Share The DOE, as part of its Clean Coal & Natural Gas Power Systems initiative, has a "Turbines of Tomorrow" program with the Program Performance Goal to: "By 2010, develop turbine technology that is capable of efficiently

296

Detection of Undocumented Changepoints Using Multiple Test Statistics and Composite Reference Series  

Science Conference Proceedings (OSTI)

An evaluation of three hypothesis test statistics that are commonly used in the detection of undocumented changepoints is described. The goal of the evaluation was to determine whether the use of multiple tests could improve undocumented, ...

Matthew J. Menne; Claude N. Williams Jr.

2005-10-01T23:59:59.000Z

297

Energy-constrained collaborative processing for target detection, tracking, and geolocation  

Science Conference Proceedings (OSTI)

While unattended ground sensors have traditionally relied upon acoustic, seismic, magnetic and non-imaging IR sensing modalities to perform detection, tracking, and recognition, imagery has the potential to greatly improve performance by introducing ...

Peter W. Boettcher; Gary A. Shaw

2003-04-01T23:59:59.000Z

298

A soft computing method for detecting lifetime building thermal insulation failures  

Science Conference Proceedings (OSTI)

The detection of thermal insulation failures in buildings in operation responds to the challenge of improving building energy efficiency. This multidisciplinary study presents a novel four-step soft computing knowledge identification model called IKBIS ...

Javier Sedano; Leticia Curiel; Emilio Corchado; Enrique de la Cal; José R. Villar

2010-04-01T23:59:59.000Z

299

Detection of radiocarbon in the cyclotrino  

Science Conference Proceedings (OSTI)

A small low energy cyclotron (the cyclotrino''), which was proposed for direct detection of radiocarbon in 1980, has now detected radiocarbon at natural abundance. This device combines the suppression of background through the use of negative ions with the high intrinsic mass resolution of a cyclotron. A high current cesium sputter negative ion source generates a beam of carbon ions which is pre-separated with Wien filter and is transported to the cyclotron via a series of electrostatic lenses. Beam is injected radially into the cyclotron using electrostatic deflectors and an electrostatic mirror. Axial focusing is entirely electrostatic. A microchannel plate detector is used with a phase-gated output. Data is presented showing resolution of radiocarbon at natural abundance. In its present form the system is capable of improving the sensitivity of detecting {sup 14}C in some biomedical experiments by a factor of 10{sup 4}. Modifications are discussed which could bring about an additional factor of 100 in sensitivity, which is important for archaeological and geological applications. Possibilities for measurements of other isotopes are discussed. 16 refs., 7 figs.

Bertsche, K.J.; Karadi, C.A.; Muller, R.A.; Paulson, G.C.

1990-04-01T23:59:59.000Z

300

Gravitational-Wave Detection using Multivariate Analysis  

E-Print Network (OSTI)

Searches for gravitational-wave bursts (transient signals, typically of unknown waveform) require identification of weak signals in background detector noise. The sensitivity of such searches is often critically limited by non-Gaussian noise fluctuations which are difficult to distinguish from real signals, posing a key problem for transient gravitational-wave astronomy. Current noise rejection tests are based on the analysis of a relatively small number of measured properties of the candidate signal, typically correlations between detectors. Multivariate analysis (MVA) techniques probe the full space of measured properties of events in an attempt to maximise the power to accurately classify events as signal or background. This is done by taking samples of known background events and (simulated) signal events to train the MVA classifier, which can then be applied to classify events of unknown type. We apply the boosted decision tree (BDT) MVA technique to the problem of detecting gravitational-wave bursts associated with gamma-ray bursts. We find that BDTs are able to increase the sensitive distance reach of the search by as much as 50%, corresponding to a factor of ~3 increase in sensitive volume. This improvement is robust against trigger sky position, large sky localisation error, poor data quality, and the simulated signal waveforms that are used. Critically, we find that the BDT analysis is able to detect signals that have different morphologies to those used in the classifier training and that this improvement extends to false alarm probabilities beyond the 3{\\sigma} significance level. These findings indicate that MVA techniques may be used for the robust detection of gravitational-wave bursts with a priori unknown waveform.

Thomas S. Adams; Duncan Meacher; James Clark; Patrick J. Sutton; Gareth Jones; Ariana Minot

2013-05-24T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Fracture detection and mapping  

DOE Green Energy (OSTI)

Because the costs of drilling, completing, and testing a well can be extremely high, it is important to develop better tools and methods for locating high permeability zones prior to drilling, and to develop better tools and methods for identifying and characterizing major fracture zones during the drilling and well testing stages. At the recommendation of the LBL Industry Review Panel on Geothermal Reservoir Technology, we organized and convened a one-day workshop this past July to discuss various aspects of DOE's current and planned activities in fracture detection, to review the geothermal industry's near-term and long-term research needs, to determine the priority of those needs, to disseminate to industry the status of research in progress, and to discuss the possibility of future joint research between industry and DOE. In this paper we present a brief overview of the workshop from the perspective of those who participated in it and provided us with written comments to a questionnaire that was distributed.

Goldstein, N.E.; Iovenitti, J.L.

1986-03-01T23:59:59.000Z

302

improve | OpenEI Community  

Open Energy Info (EERE)

improve improve Home Dc's picture Submitted by Dc(15) Member 17 September, 2013 - 12:39 Are you willing to reply to a text message once a day with information about your comfort level at your indoor location? building comfort design improve incentive indoor message sms text Yes 60% (3 votes) No 0% (0 votes) Maybe if I had an incentive 20% (1 vote) Maybe if my reply is confidential and anonymous 0% (0 votes) Maybe if the data will be used to improve building design 20% (1 vote) Total votes: 5 Buildings account for roughly 40% of all U.S. energy use (70% of all electricity): residential buildings account for 22% of all U.S. energy use and commercial buildings account for 18% of all U.S. energy use[i]. There is an unanswered need for information about buildings in use and how building design affects building occupant comfort, productivity, and, by

303

Heat Rate Improvement Reference Manual  

Science Conference Proceedings (OSTI)

Performance optimization of fossil power plants is a high priority within the electric utilities in the new competitive environment. This manual can help utility engineers establish a heat rate improvement program.

1998-07-27T23:59:59.000Z

304

An Improved Raindrop Chemistry Spectrometer  

Science Conference Proceedings (OSTI)

A spectrometer allowing size-fractional chemical analysis of raindrops has been described previously by the authors. Modifications to this raindrop chemistry spectrometer now allow improved performance in windy conditions. Instrument ...

Stuart G. Bradley; Stephen J. Adams; C. David Stow; Stephen J. de Mora

1991-08-01T23:59:59.000Z

305

Butler Rural Electric Cooperative - Energy Efficiency Improvement...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Efficiency Improvement Loan Program Butler Rural Electric Cooperative - Energy Efficiency Improvement Loan Program Eligibility Residential Savings For Home Weatherization...

306

Efficiency Improvement Opportunities for Personal Computer Monitors...  

NLE Websites -- All DOE Office Websites (Extended Search)

Efficiency Improvement Opportunities for Personal Computer Monitors: Implications for Market Transformation Programs Title Efficiency Improvement Opportunities for Personal...

307

2011 Heat Rate Improvement Conference  

Science Conference Proceedings (OSTI)

With the rising cost of fuel and the strong possibility of CO2 emissions regulations and limitations in the near future, utilities and power generation companies are focusing on power plant heat rate and performance. The Electric Power Research Institute (EPRI) 17th Heat Rate Improvement Conference is the latest in a series of meetings designed to assist attendees in addressing problems with power plant performance and in identifying cost-effective solutions for achieving and sustaining heat rate improve...

2011-03-28T23:59:59.000Z

308

Improved electrolytes for fuel cells  

DOE Green Energy (OSTI)

Present day fuel cells based upon hydrogen and oxygen have limited performance due to the use of phosphoric acid as an electrolyte. Improved performance is desirable in electrolyte conductivity, electrolyte management, oxygen solubility, and the kinetics of the reduction of oxygen. Attention has turned to fluorosulfonic acids as additives or substitute electrolytes to improve fuel cell performance. The purpose of this project is to synthesize and electrochemically evaluate new fluorosulfonic acids as superior alternatives to phosphoric acid in fuel cells. (VC)

Gard, G.L.; Roe, D.K.

1991-06-01T23:59:59.000Z

309

New Facility Focuses on Improved Radiation Standards  

Science Conference Proceedings (OSTI)

... The MIRF contains a high-energy electron beam ... used in ionizing radiation treatments for cancer ... such as polymer curing and wastewater treatment. ...

310

Method for Detecting an Element  

Using gamma ray spectrum analysis, this patented invention detects a desired element from a very small sample and by compares it to a small sample of ...

311

New Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier  

Open Energy Info (EERE)

Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Detection And Rejection Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: New Improved Equations For Na-K, Na-Li And Sio2 Geothermometers By Outlier Detection And Rejection Details Activities (1) Areas (1) Regions (0) Abstract: We present new improved equations for three still widely used Na/K, Na/Li and SiO2 geothermometers (obtained by statistical treatment of the data and application of outlier detection and rejection as well as theory of error propagation) and compare them with those by Fournier and others. New equations are also developed for estimating errors associated with the use of these new geothermometric equations and comparing them with the performance of the original equations. The errors in the use of the new

312

Techniques and Technologies for Field Detection of Asbestos Containing Materials  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE-Environmental Management DOE-Complex Wide Techniques and Technologies for Field Detection of Asbestos Containing Materials Challenge Asbestos has been used in numerous applications at DOE sites including sprayed-on fireproofing, asphalt and vinyl floor tile, and asbestos-cement (transite) siding. Inhalation of asbestos can result in non-malignant asbestosis, lung cancer and mesothelioma in workers. Currently, 40 CFR 763, Subpart E requires a certain number of bulk samples of suspected asbestos-containing material (ACM) to be collected within each designated homogeneous area (HA). If real time (or near-real), in-situ detection techniques/technologies of ï‚£ 5, and preferably ï‚£ 3 weight percent asbestos, were available, sample numbers

313

Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers  

E-Print Network (OSTI)

and Cancer Interface. Cancer Research 2007, Geigl JB, LangerBreast Cancer Research This Provisional PDF corresponds tobreast cancers Breast Cancer Research 2007, 9:R59 doi:

2007-01-01T23:59:59.000Z

314

Improving Ranking Using Quantum Probability  

E-Print Network (OSTI)

The paper shows that ranking information units by quantum probability differs from ranking them by classical probability provided the same data used for parameter estimation. As probability of detection (also known as recall or power) and probability of false alarm (also known as fallout or size) measure the quality of ranking, we point out and show that ranking by quantum probability yields higher probability of detection than ranking by classical probability provided a given probability of false alarm and the same parameter estimation data. As quantum probability provided more effective detectors than classical probability within other domains that data management, we conjecture that, the system that can implement subspace-based detectors shall be more effective than a system which implements a set-based detectors, the effectiveness being calculated as expected recall estimated over the probability of detection and expected fallout estimated over the probability of false alarm.

Melucci, Massimo

2011-01-01T23:59:59.000Z

315

Fusion of hypothesis testing for nonlinearity detection in small time series  

Science Conference Proceedings (OSTI)

The performances of parametric or non-parametric Hypothesis Testing (HT) for nonlinearity detection are fairly weak for small time series (typically between 128 and 512 samples). A natural idea to improve the results is to merge several HT to make a ... Keywords: Decision fusion, HOS methods, Hypothesis testing fusion, Mutual information, Nonlinearity detection, Signal modelling

Jean-Marc Le Caillec; Julien Montagner

2013-05-01T23:59:59.000Z

316

Volumetric modulated arc radiotherapy for esophageal cancer  

SciTech Connect

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

2012-04-01T23:59:59.000Z

317

Nuclear Detonation Detection | National Nuclear Security Administratio...  

National Nuclear Security Administration (NNSA)

Nuclear Nonproliferation Program Offices > Office of Nonproliferation Research & Development > Nuclear Detonation Detection Nuclear Detonation Detection Develop, Demonstrate, and...

318

KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials  

Science Conference Proceedings (OSTI)

Purpose: Cetuximab-containing chemotherapy is known to be effective for KRAS wild-type metastatic colorectal cancer; however, it is not clear whether cetuximab-based preoperative chemoradiation confers an additional benefit compared with chemoradiation without cetuximab in patients with locally advanced rectal cancer. Methods and Materials: We analyzed EGFR, KRAS, BRAF, and PIK3CA mutation status with direct sequencing and epidermal growth factor receptor (EGFR) and Phosphatase and tensin homolog (PTEN) expression status with immunohistochemistry in tumor samples of 82 patients with locally advanced rectal cancer who were enrolled in the IRIX trial (preoperative chemoradiation with irinotecan and capecitabine; n=44) or the ERBIRIX trial (preoperative chemoradiation with irinotecan and capecitabine plus cetuximab; n=38). Both trials were similarly designed except for the administration of cetuximab; radiation therapy was administered at a dose of 50.4 Gy/28 fractions and irinotecan and capecitabine were given at doses of 40 mg/m{sup 2} weekly and 1650 mg/m{sup 2}/day, respectively, for 5 days per week. In the ERBIRIX trial, cetuximab was additionally given with a loading dose of 400 mg/m{sup 2} on 1 week before radiation, and 250 mg/m{sup 2} weekly thereafter. Results: Baseline characteristics before chemoradiation were similar between the 2 trial cohorts. A KRAS mutation in codon 12, 13, and 61 was noted in 15 (34%) patients in the IRIX cohort and 5 (13%) in the ERBIRIX cohort (P=.028). Among 62 KRAS wild-type cancer patients, major pathologic response rate, disease-free survival and pathologic stage did not differ significantly between the 2 cohorts. No mutations were detected in BRAF exon 11 and 15, PIK3CA exon 9 and 20, or EGFR exon 18-24 in any of the 82 patients, and PTEN and EGFR expression were not predictive of clinical outcome. Conclusions: In patients with KRAS wild-type locally advanced rectal cancer, the addition of cetuximab to the chemoradiation with irinotecan plus capecitabine regimen was not associated with improved clinical outcome compared with chemoradiation without cetuximab.

Kim, Sun Young; Shim, Eun Kyung [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)] [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Yeo, Hyun Yang [Division of Translational and Clinical Research I, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)] [Division of Translational and Clinical Research I, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Baek, Ji Yeon [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)] [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Hong, Yong Sang [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)] [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Dae Yong [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of) [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Division of Translational and Clinical Research I, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Kim, Tae Won [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)] [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Jee Hyun [Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam (Korea, Republic of)] [Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam (Korea, Republic of); Im, Seock-Ah [Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of)] [Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of); Jung, Kyung Hae [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)] [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Chang, Hee Jin, E-mail: heejincmd@yahoo.com [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Division of Translational and Clinical Research I, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)

2013-01-01T23:59:59.000Z

319

Cascade-based community detection  

Science Conference Proceedings (OSTI)

Given a directed social graph and a set of past informa- tion cascades observed over the graph, we study the novel problem of detecting modules of the graph (communities of nodes), that also explain the cascades. Our key observation is that both information ... Keywords: community detection, information cascades, social networks

Nicola Barbieri; Francesco Bonchi; Giuseppe Manco

2013-02-01T23:59:59.000Z

320

An Improved Tissue Culture System  

NLE Websites -- All DOE Office Websites (Extended Search)

Improved Improved Tissue Culture System for Embryogenic Callus Production and Plant Regeneration in Switchgrass (Panicum virgatum L.) Jason N. Burris & David G. J. Mann & Blake L. Joyce & C. Neal Stewart Jr. Published online: 10 October 2009 # Springer Science + Business Media, LLC. 2009 Abstract The increased emphasis on research of dedicated biomass and biofuel crops begs for biotechnology method improvements. For switchgrass (Panicum virgatum L.), one limitation is inefficient tissue culture and transformation systems. The objectives of this study were to investigate the utility of a new medium described here, LP9, for the production and maintenance of switchgrass callus and its regeneration, which also enables genetic transformation. LP9 medium is not based on Murashige and Skoog (MS) medium, the basal medium that all published switchgrass transformation has been

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

HVAC Improvements for Existing Houses  

NLE Websites -- All DOE Office Websites (Extended Search)

HVAC Improvements for Existing Houses HVAC Improvements for Existing Houses Speaker(s): Chryséis Bovagnet Date: September 5, 2002 - 12:00pm Location: Bldg. 90 Many older houses in the US are either not well designed from a thermal point of view or have HVAC (Heating Ventilation and Air Conditioning) systems in need of repairs or improvements. The building envelopes tend to have poor insulation and lots of leakage, and the HVAC systems are inefficient. The cooling/heating equipment is often located outside of the conditioned space (e.g. in attics or crawlspaces) with ducts that leak and have poor insulation, which cause energy loss and bad occupant comfort on peak days or in extreme climates. We developed a series of retrofits that will allow us to reduce the energy consumption of residential HVAC

322

Waste Management Process Improvement Project  

SciTech Connect

The Bechtel Hanford-led Environmental Restoration Contractor team's Waste Management Process Improvement Project is working diligently with the U.S. Department of Energy's (DOE) Richland Operations Office to improve the waste management process to meet DOE's need for an efficient, cost-effective program for the management of dangerous, low-level and mixed-low-level waste. Additionally the program must meet all applicable regulatory requirements. The need for improvement was highlighted when a change in the Groundwater/Vadose Zone Integration Project's waste management practices resulted in a larger amount of waste being generated than the waste management organization had been set up to handle.

Atwood, J.; Borden, G.; Rangel, G. R.

2002-02-25T23:59:59.000Z

323

Improved Radiation Dosimetry/Risk Estimates to Facilitate Environmental Management of Plutonium-Contaminated Sites  

SciTech Connect

This report summarizes 4 years of research achievements in this Office of Science (BER), U.S. Department of Energy (DOE) project. The research described was conducted by scientists and supporting staff at Lovelace Respiratory Research Institute (LRRI)/Lovelace Biomedical and Environmental Research Institute (LBERI) and the Southern Urals Biophysics Institute (SUBI). All project objectives and goals were achieved. A major focus was on obtaining improved cancer risk estimates for exposure via inhalation to plutonium (Pu) isotopes in the workplace (DOE radiation workers) and environment (public exposures to Pu-contaminated soil). A major finding was that low doses and dose rates of gamma rays can significantly suppress cancer induction by alpha radiation from inhaled Pu isotopes. The suppression relates to stimulation of the body's natural defenses, including immunity against cancer cells and selective apoptosis which removes precancerous and other aberrant cells.

Scott, Bobby R.; Tokarskaya, Zoya B.; Zhuntova, Galina V.; Osovets, Sergey V.; Syrchikov, Victor A., Belyaeva, Zinaida D.

2007-12-14T23:59:59.000Z

324

Photovoltaic Cz Silicon Module Improvements  

DOE Green Energy (OSTI)

Work focused on reducing the cost per watt of Cz silicon photovoltaic modules under Phase II of Siemens Solar Industries' DOE/NREL PVMaT 4A subcontract is described in this report. New module designs were deployed in this phase of the contract, improvements in yield of over 10% were realized, and further implementation of Statistical Process Control was achieved during this phase. Module configurations representing a 12% cost reduction per watt were implemented in small scale production under Phase II of this contract. Yield improvements are described in detail, yield sensitivity to wafer thickness is quantified, and the deployment of SPC in critical process steps is reported here.

Jester, T. L.

1998-09-01T23:59:59.000Z

325

Bayesian methods for discontinuity detection in climate model predictions.  

Science Conference Proceedings (OSTI)

Discontinuity detection is an important component in many fields: Image recognition, Digital signal processing, and Climate change research. Current methods shortcomings are: Restricted to one- or two-dimensional setting, Require uniformly spaced and/or dense input data, and Give deterministic answers without quantifying the uncertainty. Spectral methods for Uncertainty Quantification with global, smooth bases are challenged by discontinuities in model simulation results. Domain decomposition reduces the impact of nonlinearities and discontinuities. However, while gaining more smoothness in each subdomain, the current domain refinement methods require prohibitively many simulations. Therefore, detecting discontinuities up front and refining accordingly provides huge improvement to the current methodologies.

Safta, Cosmin; Debusschere, Bert J.; Najm, Habib N.; Sargsyan, Khachik

2010-06-01T23:59:59.000Z

326

Fertility, pregnancy, and breastfeeding among younger breast cancer survivors  

E-Print Network (OSTI)

the California Breast Cancer Research Program, who awardedthe California Breast Cancer Research Program, dissertationquality of life. Breast cancer Research and Treatment. 1996;

Gorman, Jessica Lynn Rickard

2009-01-01T23:59:59.000Z

327

Physics and Cancer Student Homepage  

NLE Websites -- All DOE Office Websites (Extended Search)

tests. He had an MRI that showed a growth in the area of swelling around his salivary gland and, after a biopsy, was diagnosed with salivary gland cancer and has been recommended...

328

Steps to Preventing Colon Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

watch out for belly fat. One of the key findings from the CUP report is that excess body fat is linked to increased risk of colorectal cancer. The report also concludes that...

329

EPS Global International Cancer Conference  

NLE Websites -- All DOE Office Websites (Extended Search)

Sept.10-12th, 2010 Suzhou, China Welcome Message Dear Colleagues and Friends, It is my pleasure to announce that EPS Global International Cancer Conference will be held on...

330

DOE Mobile Detection Assessment Response System (MDARS)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Helps Pioneer "Robot" Patrol Technology: Deployment of the Helps Pioneer "Robot" Patrol Technology: Deployment of the DOE Mobile Detection Assessment Response System (MDARS) The use of patrol robots to cost effectively improve security while reducing health and safety risks at DOE and NNSA nuclear facilities is an HSS advanced technology deployment "first". Over the past 2 years, the HSS Office of Technology has played a key role in working with the Army, the National Nuclear Security Administration (NNSA), the Nevada National Security Site (NNSS) and General Dynamics Robotics Systems to purchase, prototype, test and deploy the first of three MDARS patrol robots at NNSS. In addition to the initial purchase, HSS successfully negotiated a mutually acceptable

331

An improved slicer for Java  

Science Conference Proceedings (OSTI)

We present an improved slicing algorithm for Java. The best algorithm known so far, first presented in [11], is not always precise if nested objects are used as actual parameters. The new algorithm presented in this paper always generates correct and ... Keywords: Java, object trees, static program slicing

Christian Hammer; Gregor Snelting

2004-06-01T23:59:59.000Z

332

Zymomonas with improved xylose utilization  

DOE Patents (OSTI)

Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.

Viitanen, Paul V. (West Chester, PA); Tao, Luan (Havertown, PA); Zhang, Yuying (New Hope, PA); Caimi, Perry G. (Kennett Square, PA); McCutchen, Carol M. (Wilmington, DE); McCole, Laura (East Fallowfield, PA); Zhang, Min (Lakewood, CO); Chou, Yat-Chen (Lakewood, CO); Franden, Mary Ann (Centennial, CO)

2011-08-16T23:59:59.000Z

333

Improved photovoltaic cells and electrodes  

DOE Patents (OSTI)

Improved photovoltaic cells and electrodes for use therein, particularly electrodes employing amorphous silicon or polyacetylene coating are produced by a process which includes filling pinholes or porous openings in the coatings by electrochemical oxidation of selected monomers to deposit insulating polymer in the openings.

Skotheim, T.A.

1983-06-29T23:59:59.000Z

334

Identifying and Understanding the Functional Significance of Cancer Stem Cells in Prostate and Pancreatic Cancer Initiation and Chemoresistance  

E-Print Network (OSTI)

prostate tumorigenesis. Cancer Research, 71: 3459-3470. Kongprogenitor cells. Cancer Research, 72: 1878-89. Murtaughin human brain tumors. Cancer Research, 63: 5821-5828. Steer

Hindoyan, Antreas Agop

2013-01-01T23:59:59.000Z

335

Study of familial breast cancer: identifying additional breast cancer susceptibility loci;.  

E-Print Network (OSTI)

??Breast cancer is a serious public health concern and despite intensive research, the etiology of breast cancer is poorly understood. Known risk factors explain only… (more)

Allen-Brady, Kristina Lisa

2006-01-01T23:59:59.000Z

336

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

E-Print Network (OSTI)

11.  Katoh M.  Cancer genomics and genetics of FGFR2 [Chapter 27  Breast Cancer Genomics  Paul T.  Spellman, 

Spellman, Paul T.

2011-01-01T23:59:59.000Z

337

An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration  

E-Print Network (OSTI)

of geologic carbon sequestration. Geophys Res Lett 2005;from geologic carbon sequestration sites: Unsaturated zoneverification of geologic carbon sequestration Jennifer L.

Lewicki, Jennifer L.; Hilley, George E.; Oldenburg, Curtis M.

2006-01-01T23:59:59.000Z

338

Technique for Improving Detection of WSR-88D Mesocyclone Signatures by Increasing Angular Sampling  

Science Conference Proceedings (OSTI)

The Doppler velocity signature of a thunderstorm mesocyclone becomes increasingly degraded as distance from the radar increases. Degradation is due to the broadening of the radar beam with range relative to the size of the mesocyclone. Using a ...

Vincent T. Wood; Rodger A. Brown; Dale Sirmans

2001-02-01T23:59:59.000Z

339

Critical infrastructure protection: Resource efficient sampling to improve detection of less frequent patterns in network traffic  

Science Conference Proceedings (OSTI)

Networked critical infrastructures are of national importance. However, such infrastructures are running 24/7. The supervisory control and data acquisition system (SCADA) of the critical infrastructure will generate enormous network traffic continuously. ... Keywords: Critical infrastructure, Sampling, Traffic analysis

Abdun Naser Mahmood; Jiankun Hu; Zahir Tari; Christopher Leckie

2010-07-01T23:59:59.000Z

340

Supplemental Material Improved Sensitivity Mass Spectrometric Detection of Eicosanoids by Charge  

E-Print Network (OSTI)

CN followed by centrifugation to remove precipitated protein (no solid phase extraction). 3) Elution Source Temp (o C) 130 130 Desolvation Temp (o C) 500 500 Desolvation Gas (L/Hr) 1100 1100 Cone Gas (L Gas (L/Hr) 900 900 Cone Gas (L/Hr) 0 0 Collision Cell Entrance (V) -5 -5 Collision Cell Exit (V) 0 0

Gelb, Michael

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization  

E-Print Network (OSTI)

‡, Tomas Fitzgerald‡, Richard Redon‡, Heike Fiegler‡, T Daniel Andrews‡, Barbara E Stranger‡, Andrew G Lynch†, Emmanouil T Dermitzakis‡, Nigel P Carter‡, Simon Tavaré*† and Matthew E Hurles‡ Addresses: *Computational Biology Group, Department of Applied... identifying CNVs enables more biological information to be extracted from aCGH experiments designed to investigate copy number variation in normal individuals. Published: 25 October 2007 Genome Biology 2007, 8:R228 (doi:10.1186/gb-2007-8-10-r228) Received: 3...

Marioni, John C; Thorne, Natalie P; Valsesia, Armand; Fitzgerald, Tomas; Redon, Richard; Fiegler, Heike; Andrews, T Daniel; Stranger, Barbara E; Lynch, Andrew G; Dermitzakis, Emmanouil T; Carter, Nigel P; Tavare, Simon; Hurles, Matthew E

2007-10-25T23:59:59.000Z

342

Improved monoclonal antibodies to halodeoxyuridine  

DOE Patents (OSTI)

The development, method of production, characterization and methods of use of two hybridomas, CIdU-1 (ATCC Accession No. HB-8321) and CIdU-2 (ATCC Accession No. HB-8320), are described. These secrete IgG/sub 1/(K) immunoglobulins that react with halodeoxyuridine (HdU or halodU) such as bromo, chloro, fluoro and iodo deoxyuridine (BrdU, CldU, FdU and IdU), whether these are free in solution or incorporated into single stranded DNA in whole cells. The antibodies do not react with naturally occurring free nucleic acids or with deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) polymers. These antibodies are suitable for use in enzyme immunoassays for free CldU, FdU, IdU and BrdU and for detecting cells with these nucleotides incorporated into them. The monoclonal antibodies are useful in the detection of the sensitivity of tumor cells to specific chemotherapeutic agents, in the measurement of the rate of cellular DNA synthesis, in the measurement of the rate of proliferation of normal and malignant cells and in the detection of HPRT deficiency in cells. 1 tab.

Vanderlaan, M.; Dolbeare, F.A.; Gray, J.W.; Thomas, C.B.

1983-10-18T23:59:59.000Z

343

Towards Scalable Optimal Sequence Homology Detection  

Science Conference Proceedings (OSTI)

Abstract—The field of bioinformatics and computational biol- ogy is experiencing a data revolution — experimental techniques to procure data have increased in throughput, improved in accuracy and reduced in costs. This has spurred an array of high profile sequencing and data generation projects. While the data repositories represent untapped reservoirs of rich information critical for scientific breakthroughs, the analytical software tools that are needed to analyze large volumes of such sequence data have significantly lagged behind in their capacity to scale. In this paper, we address homology detection, which is a funda- mental problem in large-scale sequence analysis with numerous applications. We present a scalable framework to conduct large- scale optimal homology detection on massively parallel super- computing platforms. Our approach employs distributed memory work stealing to effectively parallelize optimal pairwise alignment computation tasks. Results on 120,000 cores of the Hopper Cray XE6 supercomputer demonstrate strong scaling and up to 2.42 × 107 optimal pairwise sequence alignments computed per second (PSAPS), the highest reported in the literature.

Daily, Jeffrey A.; Krishnamoorthy, Sriram; Kalyanaraman, Anantharaman

2012-12-26T23:59:59.000Z

344

Physical approaches to DNA sequencing and detection  

E-Print Network (OSTI)

With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, we need a revolutionary sequencing method for the cost-effective and rapid interrogation of individual genomes. This capability is likely to be provided by a physical approach to probing DNA at the single nucleotide level. This is in sharp contrast to current techniques and instruments which probe, through chemical elongation, electrophoresis, and optical detection, length differences and terminating bases of strands of DNA. In this Colloquium we review several physical approaches to DNA detection that have the potential to deliver fast and low-cost sequencing. Center-fold to these approaches is the concept of nanochannels or nanopores which allow for the spatial confinement of DNA molecules. In addition to their possible impact in medicine and biology, the methods offer ideal test beds to study open scientific issues and challenges in the relatively unexplored area at the interface between solids, liquids, and biomolecules at the nanometer length scale. We emphasize the physics behind these methods and ideas, critically describe their advantages and drawbacks, and discuss future research opportunities in this field.

Michael Zwolak; Massimiliano Di Ventra

2007-08-20T23:59:59.000Z

345

Optimal detection of losses by thermal probes  

E-Print Network (OSTI)

We consider the discrimination of lossy bosonic channels and focus to the case when one of the values for the loss parameter is zero, i.e., we address the detection of a possible loss against the alternative hypothesis of an ideal lossless channel. This discrimination is performed by inputting one-mode or two-mode squeezed thermal states with fixed total energy. By optimizing over this class of states, we find that the optimal inputs are pure, thus corresponding to single- and two-mode squeezed vacuum states. In particular, we show that for any value of the damping rate smaller than a critical value there is a threshold on the energy that makes the two-mode squeezed vacuum state more convenient than the corresponding single-mode state, whereas for damping larger than this critical value two-mode squeezed vacua are always better. We then consider the discrimination in realistic conditions, where it is unlikely to have pure squeezing. Thus by fixing both input energy and squeezing, we show that two-mode squeezed thermal states are always better than their single- mode counterpart when all the thermal photons are directed into the dissipative channel. Besides, this result also holds approximately for unbalanced distribution of the thermal photons. Finally, we also investigate the role of correlations in the improvement of detection. For fixed input squeezing (single-mode or two-mode), we find that the reduction of the quantum Chernoff bound is a monotone function of the two-mode entanglement as well as the quantum mutual information and the quantum discord. We thus verify that employing squeezing in the form of correlations (quantum or classical) is always a resource for loss detection whenever squeezed thermal states are taken as input.

Carmen Invernizzi; Matteo G. A. Paris; Stefano Pirandola

2010-11-11T23:59:59.000Z

346

Laser Detection Of Material Thickness  

NLE Websites -- All DOE Office Websites (Extended Search)

Detection Of Material Thickness Detection Of Material Thickness Laser Detection Of Material Thickness There is provided a method for measuring material thickness. Available for thumbnail of Feynman Center (505) 665-9090 Email Laser Detection Of Material Thickness There is provided a method for measuring material thickness comprising: (a) contacting a surface of a material to be measured with a high intensity short duration laser pulse at a light wavelength which heats the area of contact with the material, thereby creating an acoustical pulse within the material: (b) timing the intervals between deflections in the contacted surface caused by the reverberation of acoustical pulses between the contacted surface and the opposite surface of the material: and (c) determining the thickness of the material by calculating the proportion of

347

Mercury Detection with Gold Nanoparticles  

E-Print Network (OSTI)

R. J. Warmack, “Detection of mercury vapor using resonatingA surface acoustic wave mercury vapor sensor,” Ieee Trans.N. E. Selin, “Integrating mercury science and policy in the

Crosby, Jeffrey

2013-01-01T23:59:59.000Z

348

Anomaly Detection at Multiple Scales  

Science Conference Proceedings (OSTI)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Anomaly Detection at Multiple Scales, or ADAMS, is a $35 million DARPA project designed to identify patterns and anomalies ...

Alain Sren Mikhayhu

2012-06-01T23:59:59.000Z

349

Event detection using trigger chain  

Science Conference Proceedings (OSTI)

This paper describes a new architecture for event detection from text documents. The proposed system correctly identifies the sentences that describe an event of interest, using trigger chain to extract its participants. It exploits supervised method ...

S. Sangeetha; R. S. Thakur; Michael Arock

2012-01-01T23:59:59.000Z

350

Validation of Polarimetric Hail Detection  

Science Conference Proceedings (OSTI)

This study describes, illustrates, and validates hail detection by a simplified version of the National Severe Storms Laboratory’s fuzzy logic polarimetric hydrometeor classification algorithm (HCA). The HCA uses four radar variables: ...

Pamela L. Heinselman; Alexander V. Ryzhkov

2006-10-01T23:59:59.000Z

351

A statistical and learning based oncogene detection and classification scheme using human cDNA expressions for ovarian carcinoma  

Science Conference Proceedings (OSTI)

In this paper, a human ovarian cDNA expression database is analyzed for detecting oncogenes and then selected oncogenes are used to identify pathological stages of ovarian carcinoma. This human ovarian cDNA expression database collects 41 patient samples ... Keywords: Artificial neural network (ANN), Gene expression analysis, Microarray database, Oncogenes, Ovarian cancer, cDNA, t-Test

Meng-Hsiun Tsai; Ching-Hao Lai; Shyr-Shen Yu

2011-08-01T23:59:59.000Z

352

Detection device for hazardous material  

DOE Patents (OSTI)

This invention is comprised of a detection device that is activated by the interaction of a hazardous chemical with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

Partin, J.K.; Grey, A.E.

1990-12-31T23:59:59.000Z

353

Detection and evaluation methods for in-situ gas hydrates  

Science Conference Proceedings (OSTI)

With the increased interest in naturally occuring hydrates, the need for improved detection and evaluation methods has also increased. In this paper, logging of hydrates is discussed and selected logs from four arctic wells are examined. A new procedure based on temperature log analysis is described. The concept of a downhole heater for use with drill stem testing is also described for testing and evaluation of hydrate intervals. 12 refs.

Goodman, M.A.; Guissani, A.P.; Alger, R.P.

1982-01-01T23:59:59.000Z

354

Microchip Technology for High-Throughput Cancer Pathology  

E-Print Network (OSTI)

Sequencing in Cancer Research . . . . 80 Appendix A: High-the Warburg Effect. Cancer Research, 2006. 66(18): p. 8927-Breast Cancer Risk. Cancer Research, 2007. 67(10): p. 4687-

Duberow, Jr, David Paul

2009-01-01T23:59:59.000Z

355

Improving the Performance of Lithium Manganese Phosphate  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving the Performance of Lithium Manganese Phosphate Title Improving the Performance of Lithium Manganese Phosphate Publication Type Journal Article Year of Publication 2009...

356

Research highlights potential for improved solar cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Potential for improved solar cells Research highlights potential for improved solar cells Research has shown that carrier multiplication is a real phenomenon in tiny semiconductor...

357

Improving Ventilation and Saving Energy: Relocatable Classroom...  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving Ventilation and Saving Energy: Relocatable Classroom Field Study Interim Report Title Improving Ventilation and Saving Energy: Relocatable Classroom Field Study Interim...

358

Improving Forecasting: A plea for historical retrospectives  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving Forecasting: A plea for historical retrospectives Title Improving Forecasting: A plea for historical retrospectives Publication Type Journal Article Year of Publication...

359

Emerging Grid Reliability Improvement Technologies  

Science Conference Proceedings (OSTI)

The initial phase of a planned comprehensive Eastern Interconnection (EI) segmentation study is complete. As part of the preparations for completion of the EI study, and to carry out a similar effort for the Western Interconnection (WI), it was necessary to first investigate the potential of other technologies to compete with segmentation. This report discusses emerging grid reliability improvement technologies, providing a perspective on the pros and cons of segmentation, the grid shock absorber concept...

2007-10-29T23:59:59.000Z

360

Improvements in solid desiccant cooling  

Science Conference Proceedings (OSTI)

The DINC (Direct-Indirect Evaporative Cooling) cycle was proposed in 1986 by Texas A and M researchers. The idea was to combine the benefits of direct and indirect evaporative cooling with desiccant dehumidifying using a rotating solid silica-gel dehumidifier. Recent parametric studies completed for the Texas Energy Research in Applications Program have developed a computer design for a nominal 3-ton system that would minimize the energy consumption (both thermal and electric) while maintaining a sensible heat ratio of 75% or less. That optimum design for the original 1986 DINC cycle was modified to improve its energy efficiency. The modifications described in this paper were: (1) staging the desiccant regeneration air and (2) recirculation of the primary air to the secondary side of the indirect evaporative cooling. Computer simulations were run to study the effect of the modifications on the performance of the system. American Refrigeration Institute (AIR) standard conditions (Ambient air at 35C, 40% R.H. and Room air at 26.7C, 50% R.H.) were used for all the modifications. Results were also compared to the familiar Pennington (ventilation) cycle. The study indicated that recirculating the indirect evaporative cooler air only degenerated the performance. However, staging a portion of the regeneration air could improve the thermal coefficient of Performance by 25% over the non-staged DINC cycle. Compared to a similar staged-regeneration Pennington cycle it is a 16% improvement in thermal COP and the sensible heat ratio was 70%.

Waugaman, D.; Kini, A.; Kettleborough, C.F. (Texas A and M Univ., College Station (United States))

1993-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Magnetic force microscopy method and apparatus to detect and image currents in integrated circuits  

DOE Patents (OSTI)

A magnetic force microscopy method and improved magnetic tip for detecting and quantifying internal magnetic fields resulting from current of integrated circuits. Detection of the current is used for failure analysis, design verification, and model validation. The interaction of the current on the integrated chip with a magnetic field can be detected using a cantilevered magnetic tip. Enhanced sensitivity for both ac and dc current and voltage detection is achieved with voltage by an ac coupling or a heterodyne technique. The techniques can be used to extract information from analog circuits.

Campbell, Ann. N. (13170-B Central SE #188, Albuquerque, NM 87123); Anderson, Richard E. (2800 Tennessee NE, Albuquerque, NM 87110); Cole, Jr., Edward I. (2116 White Cloud NE, Albuquerque, NM 87112)

1995-01-01T23:59:59.000Z

362

Ultrafast laser based coherent control methods for explosives detection  

SciTech Connect

The detection of explosives is a notoriously difficult problem, especially at stand-off, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring Optimal Dynamic Detection of Explosives (ODD-Ex), which exploits the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity to explosives signatures while dramatically improving specificity, particularly against matrix materials and background interferences. These goals are being addressed by operating in an optimal non-linear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe subpulses. Recent results will be presented.

Moore, David Steven [Los Alamos National Laboratory

2010-12-06T23:59:59.000Z

363

Direct Detection of Sub-GeV Dark Matter  

SciTech Connect

Direct detection strategies are proposed for dark matter particles with MeV to GeV mass. In this largely unexplored mass range, dark matter scattering with electrons can cause single-electron ionization signals, which are detectable with current technology. Ultraviolet photons, individual ions, and heat are interesting alternative signals. Focusing on ionization, we calculate the expected dark matter scattering rates and estimate the sensitivity of possible experiments. Backgrounds that may be relevant are discussed. Theoretically interesting models can be probed with existing technologies, and may even be within reach using ongoing direct detection experiments. Significant improvements in sensitivity should be possible with dedicated experiments, opening up a window to new regions in dark matter parameter space.

Essig, Rouven; Mardon, Jeremy; Volansky, Tomer

2012-03-20T23:59:59.000Z

364

Method for detecting an image of an object  

DOE Patents (OSTI)

A method for detecting an absorption, refraction and scatter image of an object by independently analyzing, detecting, digitizing, and combining images acquired on a high and a low angle side of a rocking curve of a crystal analyzer. An x-ray beam which is generated by any suitable conventional apparatus can be irradiated upon either a Bragg type crystal analyzer or a Laue type crystal analyzer. Images of the absorption, refraction and scattering effects are detected, such as on an image plate, and then digitized. The digitized images are simultaneously solved, preferably on a pixel-by-pixel basis, to derive a combined visual image which has dramatically improved contrast and spatial resolution over an image acquired through conventional radiology methods.

Chapman, Leroy Dean (4 Vermont Cir., Bolingbrook, IL 60440); Thomlinson, William C. (32 E. Masem, East Patchogue, NY 11772); Zhong, Zhong (Apt. I 1131 Chaping 700 E. Loop Rd., Stonybrook, NY 11790)

1999-11-16T23:59:59.000Z

365

Analysis of Senate Bill 1245: Cervical Cancer Screening Test  

E-Print Network (OSTI)

cervical cancer mortality by race/ethnicity Other researchCancer: Recommendations and Rationale. Rockville, MD: Agency for Healthcare Research

California Health Benefits Review Program (CHBRP)

2006-01-01T23:59:59.000Z

366

Long-Range Neutron Detection  

Science Conference Proceedings (OSTI)

A neutron detector designed for detecting neutron sources at distances of 50 to 100 m has been constructed and tested. This detector has a large surface area (1 m{sup 2}) to enhance detection efficiency, and it contains a collimator and shielding to achieve direction sensitivity and reduce background. An unusual feature of the detector is that it contains no added moderator, such as polyethylene, to moderate fast neutrons before they reach the {sup 3}He detector. As a result, the detector is sensitive mainly to thermal neutrons. The moderator-free design reduces the weight of the detector, making it more portable, and it also aids in achieving directional sensitivity and background reduction. Test results show that moderated fission-neutron sources of strength about 3 x 10{sup 5} n/s can be detected at a distance out to 70 m in a counting time of 1000 s. The best angular resolution of the detector is obtained at distances of 30 m or less. As the separation .distance between the source and detector increases, the contribution of scattered neutrons to the measured signal increases with a resultant decrease in the ability to detect the direction to a distant source. Applications for which the long-range detector appears to be suitable include detecting remote neutron sources (including sources in moving vehicles) and monitoring neutron storage vaults for the intrusion of humans and the effects they make on the detected neutron signal. Also, the detector can be used to measure waste for the presence of transuranic material in the presence of high gamma-ray background. A test with a neutron source (3 x 10{sup 5} n/s) in a vehicle showed that the detector could readily measure an increase in count rate at a distance of 10 m for vehicle speeds up to 35 mph (the highest speed tested). These results. indicate that the source should be detectable at this distance at speeds up to 55 mph.

AJ Peurrung; DC Stromswold; RR Hansen; PL Reeder; DS Barnett

1999-11-24T23:59:59.000Z

367

doi:10.1155/2010/953537 Review Article Nanotargeted Radionuclides for Cancer Nuclear Imaging and  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Current progress in nanomedicine has exploited the possibility of designing tumor-targeted nanocarriers being able to deliver radionuclide payloads in a site or molecular selective manner to improve the efficacy and safety of cancer imaging and therapy. Radionuclides of auger electron-, ?-, ?-, and ?-radiation emitters have been surface-bioconjugated or after-loaded in nanoparticles to improve the efficacy and reduce the toxicity of cancer imaging and therapy in preclinical and clinical studies. This article provides a brief overview of current status of applications, advantages, problems, up-to-date research and development, and future prospects of nanotargeted radionuclides in cancer nuclear imaging and radiotherapy. Passive and active nanotargeting delivery of radionuclides with illustrating examples for tumor imaging and therapy are reviewed and summarized. Research on combing different modes of selective delivery of radionuclides through nanocarriers targeted delivery for tumor imaging and therapy offers the new possibility of large increases in cancer diagnostic efficacy and therapeutic index. However, further efforts and challenges in preclinical and clinical efficacy and toxicity studies are required to translate those advanced technologies to the clinical applications for cancer patients. 1.

Internal Radiotherapy; Gann Ting; Chih-hsien Chang; Hsin-ell Wang; Te-wei Lee

2010-01-01T23:59:59.000Z

368

Genetics and molecular biology of breast cancer  

SciTech Connect

This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

1992-12-31T23:59:59.000Z

369

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network (OSTI)

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

370

NIST 'Hybrid Metrology' Method Could Improve Computer ...  

Science Conference Proceedings (OSTI)

NIST 'Hybrid Metrology' Method Could Improve Computer Chips. From NIST Tech Beat: September 5, 2012. ...

2012-09-06T23:59:59.000Z

371

Commissioning Building Systems for Improved Energy ...  

Science Conference Proceedings (OSTI)

Commissioning Building Systems for Improved Energy Performance Project. Summary: NIST will advance commercial building ...

2012-12-17T23:59:59.000Z

372

Edge Detection Algorithm for SST Images  

Science Conference Proceedings (OSTI)

An algorithm to detect fronts in satellite-derived sea surface temperature fields is presented. Although edge detection is the main focus, the problem of cloud detection is also addressed since unidentified clouds can lead to erroneous edge ...

Jean-François Cayula; Peter Cornillon

1992-02-01T23:59:59.000Z

373

Detecting Climate Signals: Some Bayesian Aspects  

Science Conference Proceedings (OSTI)

A Bayesian approach to detecting forced climate signals in a dataset is presented. First, the detection algorithm derived is shown to be capable of uniquely identifying several signals optimally. Other detection techniques are shown to be ...

Stephen S. Leroy

1998-04-01T23:59:59.000Z

374

Automate feeders to improve reliability  

SciTech Connect

Pacific Gas and Electric Co. (PG and E) improved system reliability and saved money with an alarm and control system for substation distribution switches using remote control by standard telephone-communication links. The method is especially well suited for urban and suburban areas with independent telephone and power systems. The automated systems can also add capability to areas now limited by the emergency capability. The primary distribution alarm and control system has both a substation and a field switch element. Photographs accompanying the description help to explain how the controls work. 7 figures. (DCK)

1981-01-01T23:59:59.000Z

375

Improving Energy Efficiency of Auxiliaries  

DOE Green Energy (OSTI)

The summaries of this report are: Economics Ultimately Dictates Direction; Electric Auxiliaries Provide Solid Benefits. The Impact on Vehicle Architecture Will be Important; Integrated Generators With Combined With Turbo Generators Can Meet the Electrical Demands of Electric Auxiliaries; Implementation Will Follow Automotive 42V Transition; Availability of Low Cost Hardware Will Slow Implementation; Industry Leadership and Cooperation Needed; Standards and Safety Protocols Will be Important. Government Can Play an Important Role in Expediting: Funding Technical Development; Incentives for Improving Fuel Economy; Developing Standards, Allowing Economy of Scale; and Providing Safety Guidelines.

Carl T. Vuk

2001-12-12T23:59:59.000Z

376

Directions for improved fusion reactors  

SciTech Connect

Conceptual fusion reactor studies over the past 10 to 15 years have projected systems that may be too large, complex, and costly to be of commercial interest. One main direction for improved fusion reactors points towards smaller, higher-power-density approaches. First-order economic issues (i.e., unit direct cost and cost of electricity) are used to support the need for more compact fusion reactors. A generic fusion physics/engineering/costing model is used to provide a quantiative basis for these arguments for specific fusion concepts.

Krakowski, R.A.; Miller, R.L.; Delene, J.G.

1986-01-01T23:59:59.000Z

377

APDS: Autonomous Pathogen Detection System  

SciTech Connect

An early warning system to counter bioterrorism, the Autonomous Pathogen Detection System (APDS) continuously monitors the environment for the presence of biological pathogens (e.g., anthrax) and once detected, it sounds an alarm much like a smoke detector warns of a fire. Long before September 11, 2001, this system was being developed to protect domestic venues and events including performing arts centers, mass transit systems, major sporting and entertainment events, and other high profile situations in which the public is at risk of becoming a target of bioterrorist attacks. Customizing off-the-shelf components and developing new components, a multidisciplinary team developed APDS, a stand-alone system for rapid, continuous monitoring of multiple airborne biological threat agents in the environment. The completely automated APDS samples the air, prepares fluid samples in-line, and performs two orthogonal tests: immunoassay and nucleic acid detection. When compared to competing technologies, APDS is unprecedented in terms of flexibility and system performance.

Langlois, R G; Brown, S; Burris, L; Colston, B; Jones, L; Makarewicz, T; Mariella, R; Masquelier, D; McBride, M; Milanovich, F; Masarabadi, S; Venkateswaran, K; Marshall, G; Olson, D; Wolcott, D

2002-02-14T23:59:59.000Z

378

Discriminating ultrasonic proximity detection system  

DOE Patents (OSTI)

This invention uses an ultrasonic transmitter and receiver and a microprocessor to detect the presence of an object. In the reset mode the invention uses a plurality of echoes from each ultrasonic burst to create a reference table of the echo-burst-signature of the empty monitored environment. The invention then processes the reference table so that it only uses the most reliable data. In the detection mode the invention compares the echo-burst-signature of the present environment with the reference table, detecting an object if there is a consistent difference between the echo-burst-signature of the empty monitored environment recorded in the reference table and the echo-burst-signature of the present environment.

Annala, Wayne C. (Durango, CO)

1989-01-01T23:59:59.000Z

379

Discriminating ultrasonic proximity detection system  

DOE Patents (OSTI)

This invention uses an ultrasonic transmitter and receiver and a microprocessor to detect the presence of an object. In the reset mode the invention uses a plurality of echoes from each ultrasonic burst to create a reference table of the echo-burst-signature of the empty monitored environment. The invention then processes the reference table so that it only uses the most reliable data. In the detection mode the invention compares the echo-burst-signature of the present environment with the reference table, detecting an object if there is a consistent difference between the echo-burst-signature of the empty monitored environment recorded in the reference table and the echo-burst-signature of the present environment.

Annala, W.C.

1986-12-04T23:59:59.000Z

380

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2008-09-09T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ .[.nudeic.]. .Iadd.nucleic .Iaddend.acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2009-10-06T23:59:59.000Z

382

Chromosome-Specific Staining To Detect Genetic Rearrangements Associated With Chromosome 3 And/Or Chromosone 17  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray; Joe W. (Livermore, CA); Pinkel; Daniel (Walnut Creek, CA); Kallioniemi; Olli-Pekka (Tampere, FI); Kallioniemi; Anne (Tampere, FI); Sakamoto; Masaru (Tokyo, JP)

2002-02-05T23:59:59.000Z

383

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents (OSTI)

Methods and compositions for staining based upon nucleic acid sequence that employ nudeic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Kallioniemi, Olli-Pekka (Tampere, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2002-01-01T23:59:59.000Z

384

Standoff Detection of Chemicals Using Rydberg Fingerprint ...  

applied for non-intrusive detection of combustion intermediates. The technique can be applied to detection of chemical vapors as well as residues on ...

385

Chemistry for Measurement and Detection Science  

NLE Websites -- All DOE Office Websites (Extended Search)

and Detection Science Chemistry for Measurement and Detection Science Research into alternative forms of energy, especially energy security, is one of the major national...

386

For Radiation Detection Systems – Specific Methods  

Science Conference Proceedings (OSTI)

... The test procedures outlined within this TTOP will cover radiation detection instruments used for gamma-ray and neutron detection as well as ...

2013-01-10T23:59:59.000Z

387

Nuclear Detonation Detection | National Nuclear Security Administratio...  

National Nuclear Security Administration (NNSA)

Research and Development > Nuclear Detonation Detection Nuclear Detonation Detection NNSA builds the nation's operational sensors that monitor the entire planet from space to...

388

Vehicle Detection by Sensor Network Nodes  

E-Print Network (OSTI)

frequency. Table 4.2: ? and ? Ground truth (# of vehicles)truth (# of vehicles) Detection result (# of vehicles) Tabletruth ( of vehicles) Detection result ( of vehicles) Table

Ding, Jiagen; Cheung, Sing-Yiu; Tan, Chin-woo; Varaiya, Pravin

2004-01-01T23:59:59.000Z

389

Improved intake air filtration systems  

SciTech Connect

This report comprises the results of a project sponsored by the Pipeline Research Committee of the American Gas Association (Improved Intake Air Filtration Systems). The quality of the inlet air consumed by pipeline gas turbines plays a significant role in the performance, maintenance, and economy of turbine operations. The airborne contaminants may cause degradation of compressor blades and hot gas path components, primarily by erosion, corrosion, and fouling. Machines in the pipeline fleet have a typical average loss of 3.5% in output, chiefly caused by fouling of the gas turbine compressor. It also showed that: Air contamination could be significantly reduced by the use of more efficient air filtration systems, especially through the reduction of the quantity of smaller particles ingested.'' Filters which incorporated electrostatically charged fibers (achieved through the use of triboelectric [TE] effects) offered the most promising means for developing an improvement over paper media. The purpose of this program was to validate the use of new technology for self-cleaning air inlet filtration on gas turbine pumping applications. An approach utilizing triboelectrification of fabric filters was examined by testing to determine the penetration (efficiency), cleanability, pressure drop vs flow, and dust-holding capacity of seven pairs of filter cartridges: six fabric and one paper.

Lawson, C.C. (Lawson (Calvin C.), North Wildwood, NJ (United States))

1991-09-01T23:59:59.000Z

390

DETECTION OF DRUGSTORE BEETLES IN 9975 PACKAGES USING ACOUSTIC EMISSIONS  

SciTech Connect

This report documents the initial feasibility tests performed using a commercial acoustic emission instrument for the purpose of detecting beetles in Department of Energy 9975 shipping packages. The device selected for this testing was a commercial handheld instrument and probe developed for the detection of termites, weevils, beetles and other insect infestations in wooden structures, trees, plants and soil. The results of two rounds of testing are presented. The first tests were performed by the vendor using only the hand-held instrument’s indications and real-time operator analysis of the audio signal content. The second tests included hands-free positioning of the instrument probe and post-collection analysis of the recorded audio signal content including audio background comparisons. The test results indicate that the system is promising for detecting the presence of drugstore beetles, however, additional work would be needed to improve the ease of detection and to automate the signal processing to eliminate the need for human interpretation. Mechanisms for hands-free positioning of the probe and audio background discrimination are also necessary for reliable detection and to reduce potential operator dose in radiation environments.

Shull, D.

2013-03-04T23:59:59.000Z

391

ULTRASONIC DETECTION OF SURFACE-BREAKING RAILHEAD DEFECTS  

Science Conference Proceedings (OSTI)

We recently presented measurements of defects on the railhead, using a novel pitch-catch ultrasonic system comprising of two electro-magnetic acoustic transducers (EMATs) generating and detecting Rayleigh waves. Current systems used on the UK rail network for detecting surface breaking defects are limited in speed (5 mm). The non-contact EMAT system has the potential to operate at higher line speed, improving network inspection coverage. The current system detects signals and performs an FFT in less than 1 ms, and changes in the detected signal amplitude and frequency content are used to characterise defects. A new set of simulated defects on sections of rail have been produced, including half-face slots machined normal to the railhead surface, clusters of angled slots, and pocket defects more typical of real defects. The smallest pocket defects are difficult to detect, with changes in signal amplitude and cut-off falling close to the noise level. However, at chosen higher frequencies a drop in FFT magnitude indicates the presence of a defect, and this indicator can be logically combined with amplitude and cut-off measurements to provide a more reliable result. Preparation for testing on a rotating rail rig at high speeds is ongoing.

Edwards, R. S.; Fan, Y.; Dixon, S. [University of Warwick, Department of Physics, Coventry CV4 7AL (United Kingdom); Papaelias, M.; Davis, C. L.; Roberts, C. [University of Birmingham, School of Engineering, Birmingham (United Kingdom)

2008-02-28T23:59:59.000Z

392

ANOLE Portable Radiation Detection System Field Test and Evaluation Campaign  

SciTech Connect

Handheld, backpack, and mobile sensors are elements of the Global Nuclear Detection System for the interdiction and control of illicit radiological and nuclear materials. They are used by the U.S. Department of Homeland Security (DHS) and other government agencies and organizations in various roles for border protection, law enforcement, and nonproliferation monitoring. In order to systematically document the operational performance of the common commercial off-the-shelf portable radiation detection systems, the DHS Domestic Nuclear Detection Office conducted a test and evaluation campaign conducted at the Nevada Test Site from January 18 to February 27, 2006. Named “Anole,” it was the first test of its kind in terms of technical design and test complexities. The Anole test results offer users information for selecting appropriate mission-specific portable radiation detection systems. The campaign also offered manufacturers the opportunity to submit their equipment for independent operationally relevant testing to subsequently improve their detector performance. This paper will present the design, execution, and methodologies of the DHS Anole portable radiation detection system test campaign.

Chris A. Hodge

2007-07-12T23:59:59.000Z

393

Real-time method for establishing a detection map for a network of sensors  

DOE Patents (OSTI)

A method for establishing a detection map of a dynamically configurable sensor network. This method determines an appropriate set of locations for a plurality of sensor units of a sensor network and establishes a detection map for the network of sensors while the network is being set up; the detection map includes the effects of the local terrain and individual sensor performance. Sensor performance is characterized during the placement of the sensor units, which enables dynamic adjustment or reconfiguration of the placement of individual elements of the sensor network during network set-up to accommodate variations in local terrain and individual sensor performance. The reconfiguration of the network during initial set-up to accommodate deviations from idealized individual sensor detection zones improves the effectiveness of the sensor network in detecting activities at a detection perimeter and can provide the desired sensor coverage of an area while minimizing unintentional gaps in coverage.

Nguyen, Hung D; Koch, Mark W; Giron, Casey; Rondeau, Daniel M; Russell, John L

2012-09-11T23:59:59.000Z

394

First Molecular-Level Enzyme Images Could Improve Breast-Cancer...  

NLE Websites -- All DOE Office Websites (Extended Search)

aromatase. After homing in on the placental approach, the team had to develop a battery of new techniques for enzyme capture and purification. Securing the purified...

395

Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification  

E-Print Network (OSTI)

The extracellular matrix (ECM) has been shown to be a significant source of hindrance to the transport of macromolecules in solid tumors. This thesis shows that by limiting their interstitial transport, the tumor ECM can ...

Mok, Wilson

2008-01-01T23:59:59.000Z

396

Outlier detection by logic programming  

Science Conference Proceedings (OSTI)

The development of effective knowledge discovery techniques has become a very active research area in recent years due to the important impact it has had in several relevant application domains. One interesting task therein is that of singling out anomalous ... Keywords: Outlier detection, computational complexity, logic programming, nonmonotonic reasoning

Fabrizio Angiulli; Gianluigi Greco; Luigi Palopoli

2007-12-01T23:59:59.000Z

397

Recognition driven page orientation detection  

Science Conference Proceedings (OSTI)

In document image recognition, orientation detection of the scanned page is necessary for the following procedures to work correctly as they assume that the text is well oriented. Several methods have been proposed, but most of them rely on heuristics ... Keywords: document image processing, image orientation analysis, optical character recognition

Yves Rangoni; Faisal Shafait; Joost Van Beusekom; Thomas M. Breuel

2009-11-01T23:59:59.000Z

398

Anomalous change detection in imagery  

DOE Patents (OSTI)

A distribution-based anomaly detection platform is described that identifies a non-flat background that is specified in terms of the distribution of the data. A resampling approach is also disclosed employing scrambled resampling of the original data with one class specified by the data and the other by the explicit distribution, and solving using binary classification.

Theiler, James P. (Los Alamos, NM); Perkins, Simon J. (Santa Fe, NM)

2011-05-31T23:59:59.000Z

399

Heart Disease Detection Using Wavelets  

Science Conference Proceedings (OSTI)

We develop a wavelet based method to obtain standardized gray?scale chart of both healthy hearts and of hearts suffering left ventricular hypertrophy. The hypothesis that early bad functioning of heart can be detected must be tested by comparing the wavelet analysis of the corresponding ECD with the limit cases. Several important parameters shall be taken into account such as age

A. González S.; J. L. Acosta P.; M. Sandoval M.

2004-01-01T23:59:59.000Z

400

Role of Adjuvant Chemoradiotherapy for Resected Extrahepatic Biliary Tract Cancer  

SciTech Connect

Purpose: To evaluate the effect of adjuvant chemoradiotherapy (CRT) on locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) for patients with extrahepatic biliary tract cancer treated with curative resection. Methods and Materials: The study involved 168 patients with extrahepatic biliary tract cancer undergoing curative resection between August 2001 and April 2009. Of the 168 patients, 115 received adjuvant CRT (CRT group) and 53 did not (no-CRT group). Gender, age, tumor size, histologic differentiation, pre- and postoperative carbohydrate antigen 19-9 level, resection margin, vascular invasion, perineural invasion, T stage, N stage, overall stage, and the use of adjuvant CRT were analyzed to identify the prognostic factors associated with LRC, DFS, and OS. Results: For all patients, the 5-year LRC, DFS, and OS rate was 54.8%, 30.6%, and 33.9%, respectively. On univariate analysis, the 5-year LRC, DFS, and OS rates in the CRT group were significantly better than those in the no-CRT group (58.5% vs. 44.4%, p = .007; 32.1% vs. 26.1%, p = .041; 36.5% vs. 28.2%, p = .049, respectively). Multivariate analysis revealed that adjuvant CRT was a significant independent prognostic factor for LRC, DFS, and OS (p < .05). Conclusion: Our results have suggested that adjuvant CRT helps achieve LRC and, consequently, improves DFS and OS in patients with extrahepatic biliary tract cancer.

Kim, Tae Hyun; Han, Sung-Sik; Park, Sang-Jae, E-mail: k2onco@ncc.re.kr; Lee, Woo Jin; Woo, Sang Myung; Moon, Sung Ho; Yoo, Tae; Kim, Sang Soo; Kim, Seong Hoon; Hong, Eun Kyung; Kim, Dae Yong; Park, Joong-Won

2011-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

An Improved Simple Chilled Water Cooling Coil Model  

NLE Websites -- All DOE Office Websites (Extended Search)

An Improved Simple Chilled Water Cooling Coil Model An Improved Simple Chilled Water Cooling Coil Model Title An Improved Simple Chilled Water Cooling Coil Model Publication Type Conference Paper LBNL Report Number LBNL-6031E Year of Publication 2012 Authors Wang, Liping, Philip Haves, and Walter F. Buhl Conference Name SimBuild 2012 IBPSA Conference Date Published 08/2012 Abstract The accurate prediction of cooling and dehumidification coil performance is important in model-based fault detection and in the prediction of HVAC system energy consumption for support of both design and operations. It is frequently desirable to use a simple cooling coil model that does not require detailed specification of coil geometry and material properties. The approach adopted is to match the overall UA of the coil to the rating conditions and to estimate the air-side and water-side components of the UA using correlations developed by Holmes (1982). This approach requires some geometrical information about the coil and the paper investigates the sensitivity of the overall performance prediction to uncertainties in this information, including assuming a fixed ratio of air-side to water-side UA at the rating condition. Finally, simulation results from different coil models are compared, and experimental data are used to validate the improved cooling coil model.

402

A Protein that Repairs Damage to Cancer Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

An X-ray Vortex on the Horizon? An X-ray Vortex on the Horizon? How Two Drops Become One Scientists Discover How Nanocluster Contaminants Increase Risk of Spreading Mobile RNA is Poised and Ready Glass Does a Double-Take Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Protein that Repairs Damage to Cancer Cells MAY 5, 2008 Bookmark and Share The ABH2-DNA complex. A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells. Because one of the proteins detects and repairs DNA damage that may result from a certain type of cancer therapy, the researchers raised the possibility of designing a molecule that could interfere with the repair process, making cancer

403

Green Cooling: Improving Chiller Efficiency  

NLE Websites -- All DOE Office Websites (Extended Search)

1 1 Green Cooling: Improving Chiller Efficiency This new chiller simulation module being developed by Building Performance Assurance Project members will help building managers compare optimal and actual chiller efficiency. Chillers are the single largest energy consumers in commercial buildings. These machines create peaks in electric power consumption, typically during summer afternoons. In fact, 23% of electricity generation is associated with powering chillers that use CFCs and HCFCs, ozone-depleting refrigerants. Satisfying the peak demand caused by chillers forces utilities to build new power plants. However, because chiller plants run the most when the weather is hot and very little at other times, their load factors - and hence the utilities' load factors (the percentage of time the

404

IMPROVE and Other National Programs  

E-Print Network (OSTI)

Atmospheric deposition is the result of air pollution gases and aerosols leaving the atmosphere as “dry ” or “wet ” deposition. Little is known about just how much pollution is deposited onto soils, lakes and streams. To determine the extent and trends of forest exposure to air pollution, various types of monitoring have been conducted. In this study, we evaluate data from different rural air monitoring programs to determine whether or not they may have wider applications in resource monitoring and protection. This report analyzes location-specific data collected by three national programs: The CASTNET (NDDN) Network supported by the Environmental Protection Agency, the IMPROVE (Interagency Monitoring of Protected Visual Environments) network supported by federal land managers, and the NADP/NTN program supported by many agencies.

United States; Forest Service; Karl Zeller; Debra Youngblood Harrington; Richard Fisher; Evgeny Donev Abstract; Karl Harrington; Debra Youngblood Fisher; Richard Donev; Evgeny Determining

2000-01-01T23:59:59.000Z

405

Improvements of biomass deconstruction enzymes  

DOE Green Energy (OSTI)

Sandia National Laboratories and DSM Innovation, Inc. collaborated on the investigation of the structure and function of cellulases from thermophilic fungi. Sandia's role was to use its expertise in protein structure determination and X-ray crystallography to solve the structure of these enzymes in their native state and in their substrate and product bound states. Sandia was also tasked to work with DSM to use the newly solved structure to, using computational approaches, analyze enzyme interactions with both bound substrate and bound product; the goal being to develop approaches for rationally designing improved cellulases for biomass deconstruction. We solved the structures of five cellulases from thermophilic fungi. Several of these were also solved with bound substrate/product, which allowed us to predict mutations that might enhance activity and stability.

Sale, K. L.

2012-03-01T23:59:59.000Z

406

Hadronic Screening in Improved Taste  

E-Print Network (OSTI)

We present our results on meson and nucleon screening masses in finite temperature two flavour QCD using smeared staggered valence quarks and staggered thin-link sea quarks with different lattice spacings and quark masses. We investigate optimization of smearing by observing its effects on the infrared (IR) and ultraviolet (UV) components of gluon and quark fields. The application of smearing to screening at finite temperature also provides a transparent window into the mechanism of the interplay of smearing and chiral symmetry. The improved hadronic operators show that above the finite temperature cross over, T_c, screening masses are consistent with weak-coupling predictions. There is also evidence for a rapid opening up of a spectral gap of the Dirac operator immediately above T_c.

Sourendu Gupta; Nikhil Karthik

2013-02-20T23:59:59.000Z

407

Catalysts for improved fuel processing  

DOE Green Energy (OSTI)

This report covers our technical progress on fuel processing catalyst characterization for the specific purpose of hydrogen production for proton-exchange-membrane (PEM) fuel cells. These development efforts support DOE activities in the development of compact, transient capable reformers for on-board hydrogen generation starting from candidate fuels. The long-term objective includes increased durability and lifetime, in addition to smaller volume, improved performance, and other specifications required meeting fuel processor goals. The technical barriers of compact fuel processor size, transient capability, and compact, efficient thermal management all are functions of catalyst performance. Significantly, work at LANL now tests large-scale fuel processors for performance and durability, as influenced by fuels and fuel constituents, and complements that testing with micro-scale catalyst evaluation which is accomplished under well controlled conditions.

Borup, R.L.; Inbody, M.A. [and others

2000-09-01T23:59:59.000Z

408

Differential expression of anterior gradient gene AGR2 in prostate cancer  

E-Print Network (OSTI)

circulating tumor cells. Cancer research 2005, 48. Kovalev2 in prostate cancer. Cancer research 2010, 19. Zhang Y,cellular transformation. Cancer research 2008, 68(2):492-

2010-01-01T23:59:59.000Z

409

Improved correlations for retrograde gases  

E-Print Network (OSTI)

Three correlations for retrograde gases have been developed. First, a correlation was developed that relates the composition of a retrograde gas-condensate mixture at any depletion stage to the composition at its dew point pressure. This correlation is as accurate as previous correlations, and in addition, to the composition, it includes the trends for molecular weight of heptanes plus fraction (A4WC7+), specific gravity of heptanes plus fraction (SGC7+), gas produced (GP) and fraction of liquid (FL). Second, a correlation to describe the molar distribution Of C7+ of a gas-condensate mixture as a function of carbon number (CN), the C6 mole fraction and the properties Of C7+ has been developed. For comparison, the Ahmed, et aL, and Whitson methods were evaluated using a data base of 52 extended (from C]5+ and up) retrograde gascondensate samples. The evaluation of the Ahmed, et al. and Whitson methods showed that both methods are better than the new method. The Ahmed, et aL method does a better overall job than the Vvlhitson method. Comparing the relative error, Ahmed, et al. method had an error of 20.6 percent, and Whitson's method had an error of 25.1 percent. Third, a new and improved retrograde dew point pressure correlation has been developed. The new dew point correlation is an improvement of the Kennedy-Nemeth dew point correlation. Contrary to the Kennedy-Nemeth correlation, temperature is not included in the new correlation. The new dew point correlation is based on composition and the C7+ properties, molecular weight and specific gravity of the heptanes plus fraction.

Crogh, Arne

1996-01-01T23:59:59.000Z

410

Layered security architecture for masquerade attack detection  

Science Conference Proceedings (OSTI)

Masquerade attack refers to an attack that uses a fake identity, to gain unauthorized access to personal computer information through legitimate access identification. Automatic discovery of masqueraders is sometimes undertaken by detecting significant ... Keywords: anomaly detection, intrusion detection system, masquerade detection, user profiling

Hamed Saljooghinejad; Wilson Naik Bhukya

2012-07-01T23:59:59.000Z

411

Metal Detectives: New Book Details Titanic Investigation  

Science Conference Proceedings (OSTI)

Metal Detectives: New Book Details Titanic Investigation. For Immediate Release: April 15, 2008. ...

2012-10-02T23:59:59.000Z

412

Fake iris detection by using purkinje image  

Science Conference Proceedings (OSTI)

Fake iris detection is to detect and defeat a fake (forgery) iris image input. To solve the problems of previous researches on fake iris detection, we propose the new method of detecting fake iris attack based on the Purkinje image. Especially, we calculated ...

Eui Chul Lee; Kang Ryoung Park; Jaihie Kim

2006-01-01T23:59:59.000Z

413

Acoustic Inspection Devices: Detecting the Undetectable  

Acoustic Inspection Devices: Detecting the Undetectable Emerging homeland security threats and increasingly sophisticated adversaries have heightened ...

414

On-line early fault detection and diagnosis of municipal solid waste incinerators  

Science Conference Proceedings (OSTI)

A fault detection and diagnosis framework is proposed in this paper for early fault detection and diagnosis (FDD) of municipal solid waste incinerators (MSWIs) in order to improve the safety and continuity of production. In this framework, principal component analysis (PCA), one of the multivariate statistical technologies, is used for detecting abnormal events, while rule-based reasoning performs the fault diagnosis and consequence prediction, and also generates recommendations for fault mitigation once an abnormal event is detected. A software package, SWIFT, is developed based on the proposed framework, and has been applied in an actual industrial MSWI. The application shows that automated real-time abnormal situation management (ASM) of the MSWI can be achieved by using SWIFT, resulting in an industrially acceptable low rate of wrong diagnosis, which has resulted in improved process continuity and environmental performance of the MSWI.

Zhao Jinsong [College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: jinsongzhao@mail.tsinghua.edu.cn; Huang Jianchao [College of Information Science and Technology, Beijing Institute of Technology, Beijing 10086 (China); Sun Wei [College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China)

2008-11-15T23:59:59.000Z

415

Integrated Technology for Distribution Systems Applications: Survey and Testing of Voltage Detecting/Indicating Devices for AC Power Lines  

Science Conference Proceedings (OSTI)

This report summarizes product reviews and testing commercially available voltage-sensing devices used to detect energized electric distribution lines, with particular focus on minimum detection and indication performance. To adequately detect line energization across the entire spectrum of possible voltage levels on a power line (from 40 Vac to full line voltage), multiple devices are currently necessary. The ideal improvement to address current gaps in voltage sensing would be the development of a ...

2013-12-17T23:59:59.000Z

416

Adjuvant Brachytherapy Removes Survival Disadvantage of Local Disease Extension in Stage IIIC Endometrial Cancer: A SEER Registry Analysis  

SciTech Connect

Purpose: To assess the role of radiotherapy (RT) in women with Stage IIIC endometrial cancer. Methods and Materials: The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with lymph node-positive non-Stage IV epithelial endometrial cancer diagnosed and treated between 1988 and 1998. Two subgroups were identified: those with organ-confined Stage IIIC endometrial cancer and those with Stage IIIC endometrial cancer with direct extension of the primary tumor. RT was coded as external beam RT (EBRT) or brachytherapy (BT). Observed survival (OS) was reported with a minimum of 5 years of follow-up; the survival curves were compared using the log-rank test. Results: The therapy data revealed 611 women with Stage IIIC endometrial cancer during this period. Of these women, 51% were treated with adjuvant EBRT, 21% with EBRT and BT, and 28% with no additional RT (NAT). Of the 611 patients, 293 had organ-confined Stage IIIC endometrial cancer and 318 patients had Stage IIIC endometrial cancer with direct extension of the primary tumor. The 5-year OS rate for all patients was 40% with NAT, 56% after EBRT, and 64% after EBRT/BT. Adjuvant RT improved survival compared with NAT (p <0.001). In patients with organ-confined Stage IIIC endometrial cancer, the 5-year OS rate was 50% for NAT, 64% for EBRT, and 67% for EBRT/BT. Again, adjuvant RT contributed to improved survival compared with NAT (p = 0.02). In patients with Stage IIIC endometrial cancer and direct tumor extension, the 5-year OS rate was 34% for NAT, 47% for EBRT, and 63% for EBRT/BT. RT improved OS compared with NAT (p <0.001). Also, in this high-risk subgroup, adding BT to EBRT was superior to EBRT alone (p = 0.002). Conclusion: Women with Stage IIIC endometrial cancer receiving adjuvant EBRT and EBRT/BT had improved OS compared with patients receiving NAT. When direct extension of the primary tumor was present, the addition of BT to EBRT was even more beneficial.

Rossi, Peter J. [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States)], E-mail: rossi@radonc.emory.org; Jani, Ashesh B. [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States); Horowitz, Ira R. [Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA (United States); Johnstone, Peter A.S. [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States)

2008-01-01T23:59:59.000Z

417

Neutron Detection Efficiency of the  

E-Print Network (OSTI)

on improving the physical model used for neutron scattering in the resonance region. In many cases, the physical model for neutron scattering must take into account the motion of the target nuclei [2International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009

Gilfoyle, Jerry

418

Using Dashboards to Improve Energy and Comfort in Federal Buildings  

NLE Websites -- All DOE Office Websites (Extended Search)

Using Dashboards to Improve Energy and Comfort in Federal Buildings Using Dashboards to Improve Energy and Comfort in Federal Buildings Title Using Dashboards to Improve Energy and Comfort in Federal Buildings Publication Type Report LBNL Report Number LBNL-4283E Year of Publication 2011 Authors Marini, Kyle, Girish Ghatikar, and Richard C. Diamond Call Number LBNL-4283E Keywords commercial buildings, dashboards, energy, feedback, monitoring Abstract Federal agencies are taking many steps to improve the sustainability of their operations, including improving the energy efficiency of their buildings, promoting recycling and reuse of materials, encouraging carpooling and alternative transit schemes, and installing low flow water fixture units are just a few of the common examples. However, an often overlooked means of energy savings is to provide feedback to building users about their energy use through information dashboards connected to a building's energy information system.An Energy Information System (EIS), broadly defined, is a package of performance monitoring software, data acquisition hardware, and communication systems that is used to collect, store, analyze, and display energy information. At a minimum, the EIS provides the whole-building energy-use information (Granderson 2009a). We define a "dashboard" as a display and visualization tool that utilizes the EIS data and technology to provide critical information to users. This information can lead to actions resulting in energy savings, comfort improvements, efficient operations, and more. The tools to report analyzed information have existed in the information technology as business intelligence (Few 2006). The dashboard is distinguished from the EIS as a whole, which includes additional hardware and software components to collect and storage data, and analysis for resources and energy management (Granderson 2009b). EIS can be used for a variety of uses, including benchmarking, base-lining, anomaly detection, off-hours energy use evaluation, load shape optimization, energy rate analysis, retrofit and retro-commissioning savings (Granderson 2009a). The use of these EIS features depends on the specific users. For example, federal and other building managers may use anomaly detection to identify energy waste in a specific building, or to benchmark energy use in similar buildings to identify energy saving potential and reduce operational cost. There are several vendors of EIS technology that provide information on energy and other environmental variables in buildings.

419

Methods to improve and measure texture of sorghum cookies  

E-Print Network (OSTI)

The effect of wheat flour substitution with sorghum flour (SF) on the quality of cookies was evaluated. The three point bending test and sensory panels were used to evaluate changes in cookie texture and acceptability. The formulations used were a Mexican style, standard AACC recipe, and a chocolate chip type. The Mexican style cookie was optimum to evaluate changes in SF on cookie quality. Mexican style cookies made with 100% SF were very gritty, dry and fragile. The chocolate chip cookies had improved palatability, although they remained fragile. Intensive milling methods increased the amount of damaged starch, reduced particle size and moisture in the flour in hopes of improving cookie quality. Milling detoxicated sorghum with a Udy cyclone mill was the best alternative. Flours with higher damaged starch (1x and 2x Udy milled, 11 and 16% DS) produced better cookies than flour with low damaged starch (Sr. milled, 7% DS). Substitution with native corn or sorghum starch did not improve cookie texture. Substituting 5% of SF with pregelatinized waxy corn starch (PCS) or with 10% vital wheat gluten improved the Mexican style cookie quality, making them less gritty and more resistant to breakage during handling, having bending force values close to wheat flour control. Enzymes (?-amylase, xylanase, pentosanase, and protease) and two reducing agents (L-cysteine and sodium metabisulfite) at different concentrations did not have detectable effects on Mexican style cookies made with 100% SF. Environmental SEM analysis was helpful in detecting the continuous starch/lipid phase in the chocolate chip formulation that coated the sharp edges of SF particles in the cookie. The Mexican style cookie crumb improved when 5% PCS was added; more air tunnels developed within the crumb with thicker walls and a starchy continuous matrix that functioned like gluten did in the wheat flour cookie. Sensory evaluation confirmed the improvement in cookie texture for sorghum flours with higher damaged starch levels and when 5% PCS-95% SF ratios were used. Sorghum flour can be used in various cookie formulations to levels as high as 95% in combination with 5% PCS and up to 50% in combination with 50% wheat flour.

Leon-Chapa, Martha Cecilia

1999-01-01T23:59:59.000Z

420

East-West Symposium on nasopharyngeal cancer  

Science Conference Proceedings (OSTI)

Background: To achieve greater understanding of the epidemiology, pathogenesis, molecular oncology, diagnostic, and therapeutic aspects of nasopharyngeal cancer (NPC), an international meeting was held in June 2005, Toronto, Canada. Results: Further insights were obtained into the role of EBV in NPC development, with its diverse effects ranging from proliferative signals via NF-kB, to immunesuppression, to angiogenic gene regulation. Subsequently, multiple pathways are dysregulated in NPC as revealed by expression array analyses, including apoptosis, integrin, and B-catenin cascades. Advances have been made in the diagnosis and monitoring of NPC, using transoral brushings and plasma levels of EBV transcripts, which may not directly correlate with the number of circulating tumor cells, but is nevertheless informative in predicting and tracking disease response. Many novel therapies have promising results, particularly in the areas of immunotherapies, and the exploration of molecularly targeted approaches such as cetuximab or histone deacetylase inhibitors. Conclusions: The results from large randomized trials and meta-analyses have consistently demonstrated the benefit of concurrent chemotherapy with curative radiation therapy, but at a cost of greater acute and late-tissue toxicities. Further advances are required to achieve an improved understanding on the inter-relationship between environmental and genetic determinants in NPC development, to reduce the global burden of this disease. At the same time, novel therapeutic approaches are necessary to increase curability of NPC, but with reduced long-term toxicities.

Liu, F.-F. [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada) and Department of Radiation Oncology, University of Toronto, Toronto (Canada) and Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada) and Department of Medical Biophysics, University of Toronto, Toronto (Canada)]. E-mail: Fei-Fei.Liu@rmp.uhn.on.ca; Frappier, Lori [Department of Microbiology, University of Toronto, Toronto (Canada); Kim, John [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Radiation Oncology, University of Toronto, Toronto (Canada); O'Sullivan, Brian [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Radiation Oncology, University of Toronto, Toronto (Canada); Hui, Angela [Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada); Bastianutto, Carlo [Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada)

2007-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

SLAC National Accelerator Laboratory - Designer Glue Improves...  

NLE Websites -- All DOE Office Websites (Extended Search)

Designer Glue Improves Lithium-ion Battery Life By Mike Ross August 19, 2013 When it comes to improving the performance of lithium-ion batteries, no part should be overlooked - not...

422

Nontoxic quantum dot research improves solar cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Nontoxic quantum dot research improves solar cells Nontoxic quantum dot research improves solar cells Solar cells made with low-cost, nontoxic copper-based quantum dots can achieve...

423

Change What? Identifying Quality Improvement Targets by ...  

Science Conference Proceedings (OSTI)

Feb 24, 2010 ... quality improvement recommendations based on existing data to improve the effectiveness of ... Adm Policy Ment Health (2010) 37:15–26 ..... include higher doses of procedures that are common among. EB practices (Mueller ...

424

Method for detecting toxic gases  

DOE Patents (OSTI)

A method capable of detecting low concentrations of a pollutant or other component in air or other gas, utilizing a combination of a heating filament having a catalytic surface of a noble metal for exposure to the gas and producing a derivative chemical product from the component, and an electrochemical sensor responsive to the derivative chemical product for providing a signal indicative of the product. At concentrations in the order of about 1-100 ppm of tetrachloroethylene, neither the heating filament nor the electrochemical sensor is individually capable of sensing the pollutant. In the combination, the heating filament converts the benzyl chloride to one or more derivative chemical products which may be detected by the electrochemical sensor.

Stetter, Joseph R. (Naperville, IL); Zaromb, Solomon (Hinsdale, IL); Findlay, Jr., Melvin W. (Bolingbrook, IL)

1991-01-01T23:59:59.000Z

425

Acquisition and Project Management Continuous Improvement Presentation...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Continuous Improvement presentation More Documents & Publications 2012 Congressional Nuclear Cleanup Caucus Briefings Energy Storage & Power Electronics 2008 Peer Review -...

426

Improved Energy Management during Anode Setting Activity  

Science Conference Proceedings (OSTI)

About this Abstract. Meeting, 2012 TMS Annual Meeting & Exhibition. Symposium , Aluminum Reduction Technology. Presentation Title, Improved Energy ...

427

Operational Efficiency Improvements Resulting from Monitoring and ...  

Science Conference Proceedings (OSTI)

In heat treatment facilities, the customer would find potential efficiency improvements on generators, radiant tubes, furnaces, ovens, heaters, and boilers

428

Improving the design of solar cells  

Science Conference Proceedings (OSTI)

Improving the design of solar cells. Photovoltaic (PV) systems convert the sun's light directly to electrical power by absorption ...

2012-10-02T23:59:59.000Z

429

Improved Modular CSSX Unit (MCU) Operations  

• Change Distributed Control System software to reflect new flowsheet • Develop on-line solvent analysis technology – DSSHT – SEHT. Improved MCU ...

430

Improved Organic Photovoltaics - Energy Innovation Portal  

Solar Photovoltaic Improved Organic Photovoltaics B4 Materials For Organic Semiconductor Applications, Including Molecular Electronics And Organic Photovoltaics

431

Resources and Training for Continuous Program Improvement ...  

Science Conference Proceedings (OSTI)

About this Abstract. Meeting, Materials Science & Technology 2013. Symposium, Continuous Improvement of Academic Programs (and Satisfying ABET Along ...

432

Energy Savings by Cell Design Improvements  

Science Conference Proceedings (OSTI)

Mar 3, 2011 ... Aluminum Reduction Technology: Energy Savings by Cell Design Improvements Sponsored by: The Minerals, Metals and Materials Society, ...

433

Improving the discovery potential of charged Higgs bosons at the Tevatron and Large Hadron Collider  

E-Print Network (OSTI)

We outline several improvements to the experimental analyses carried out at Tevatron (Run 2) or simulated in view of the Large Hadron Collider (LHC) that could increase the scope of CDF/D0 and ATLAS/CMS in detecting charged Higgs bosons

S. Moretti

2002-05-10T23:59:59.000Z

434

Detection of a concealed object  

SciTech Connect

Disclosed are systems, methods, devices, and apparatus to determine if a clothed individual is carrying a suspicious, concealed object. This determination includes establishing data corresponding to an image of the individual through interrogation with electromagnetic radiation in the 200 MHz to 1 THz range. In one form, image data corresponding to intensity of reflected radiation and differential depth of the reflecting surface is received and processed to detect the suspicious, concealed object.

Keller, Paul E. (Richland, WA); Hall, Thomas E. (Kennewick, WA); McMakin, Douglas L. (Richland, WA)

2008-04-29T23:59:59.000Z

435

Detection of malicious computer executables  

SciTech Connect

A method of detecting malicious binary executable files is accomplished by inputting a binary executable file; converting the binary executable file to byte hexadecimal text strings; calculating the frequency of each byte pattern in the byte hexadecimal text strings; selecting characteristic byte pattern frequencies as discriminating features; classifying the discriminating features as malicious or benign; labeling the binary executable file as malicious or benign; and outputting the labeled malicious or benign binary executable file.

Cai, Dongming M. (Los Alamos, NM); Gokhale, Maya (Los Alamos, NM)

2009-04-14T23:59:59.000Z

436

Multiplex detection of agricultural pathogens  

DOE Patents (OSTI)

Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample.

Siezak, Thomas R.; Gardner, Shea; Torres, Clinton; Vitalis, Elizabeth; Lenhoff, Raymond J.

2013-01-15T23:59:59.000Z

437

Multiplex detection of agricultural pathogens  

DOE Patents (OSTI)

Described are kits and methods useful for detection of seven agricultural pathogens (BPSV; BHV; BVD; FMDV; BTV; SVD; and VESV) in a sample. Genomic sequence information from 7 agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample.

McBride, Mary Teresa (Brentwood, CA); Slezak, Thomas Richard (Livermore, CA); Messenger, Sharon Lee (Kensington, CA)

2010-09-14T23:59:59.000Z

438

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer  

SciTech Connect

Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

Zeng Hui [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Yuan Zhu [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Zhu Hong [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Lei; Shi Huashan [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Xiao Jianghong [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)] [State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China); Li Zhiping, E-mail: lizhiping620312@yahoo.com.cn [Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province (China)

2012-11-15T23:59:59.000Z

439

Compensated intruder-detection systems  

DOE Patents (OSTI)

Intruder-detection systems in which intruder-induced signals are transmitted through a medium also receive spurious signals induced by changes in a climatic condition affecting the medium. To combat this, signals received from the detection medium are converted to a first signal. The system also provides a reference signal proportional to climate-induced changes in the medium. The first signal and the reference signal are combined for generating therefrom an output signal which is insensitive to the climatic changes in the medium. An alarm is energized if the output signal exceeds a preselected value. In one embodiment, an acoustic cable is coupled to a fence to generate a first electrical signal proportional to movements thereof. False alarms resulting from wind-induced movements of the fence (detection medium) are eliminated by providing an anemometer-driven voltage generator to provide a reference voltage proportional to the velocity of wind incident on the fence. An analog divider receives the first electrical signal and the reference signal as its numerator and denominator inputs, respectively, and generates therefrom an output signal which is insensitive to the wind-induced movements in the fence.

McNeilly, David R. (Maryville, TN); Miller, William R. (Andersonville, TN)

1984-01-01T23:59:59.000Z

440

An approach for exploring code improving transformations  

Science Conference Proceedings (OSTI)

Although code transformations are routinely applied to improve the performance of programs for both scalar and parallel machines, the properties of code-improving transformations are not well understood. In this article we present a framework that enables ... Keywords: automatic generation of optimizers, code-improving transformations, enabling and disabling of optimizations, parallelizing transformations, specification of program optimizations

Deborah L. Whitfield; Mary Lou Soffa

1997-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Photovoltaic concentrator module improvements study  

DOE Green Energy (OSTI)

This report presents results of a project to design and fabricate an improved photovoltaic concentrator module. Using previous work as a baseline, this study conducted analyses and testing to select major module components and design features. The lens parquet and concentrator solar cell were selected from the highest performing, available components. A single 185X point-focus module was fabricated by the project team and tested at Sandia. Major module characteristics include a 6 by 4 compression-molded acrylic lens parquet (0.737 m{sup 2} area), twenty-four 0.2 ohms-cm, FZ, p-Si solar cells (1.56 cm{sup 2} area) soldered to ceramic substrates and copper heat spreaders, and an aluminized steel housing with corrugated bottom. This project marked the first attempt to use prismatic covers on solar cells in a high-concentration, point-focus application. Cells with 15 percent metallization were obtained, but problems with the fabrication and placement of prismatic covers on these cells lead to the decision not to use covers in the prototype module. Cell assembly fabrication, module fabrication, and module optical design activities are presented here. Test results are also presented for bare cells, cell assemblies, and module. At operating conditions of 981 watts/m{sup 2} DNI and an estimated cell temperature of 65{degrees}C, the module demonstrated an efficiency of 13.9 percent prior to stressed environmental exposure. 12 refs., 56 figs., 7 tabs.

Levy, S.L.; Kerschen, K.A. (Black and Veatch, Kansas City, MO (United States)); Hutchison, G. (Solar Kinetics, Inc., Dallas, TX (United States)); Nowlan, M.J. (Spire Corp., Bedford, MA (United States))

1991-08-01T23:59:59.000Z

442

Gasification Product Improvement Facility status  

SciTech Connect

The objective of the Gasification Product Improvement Facility (GPIF) project is to provide a test site to support early commercialization of the Integrated Gasification Combined Cycle (IGCC) technology. The design of this facility will by based on PyGas{trademark}, a patented air blown fixed bed gasification process. The GPIF will be capable of processing run-of-mine high swelling coals that comprise 87% of all Eastern US coals. The GPIF project is expected to deliver a gasifier design that will satisfy the criteria for good process performance and cost effectiveness. The PyGas{trademark} process was conceived to handle high swelling coals, crack tars, and reduce ammonia and trace metal emissions. The GPIF program will generate useful scale up data. Initially, the PyGas{trademark}-IGCC systems will be offered as modular units for the repowering markets which will reduce the financial burden on utilities in comparison to large plants. In addition, modular designs will also reduce the plant construction schedules.

Carson, R.D.; Sadowski, R.S.; Skinner, W.H. [CRS Sirrine Engineers, Inc., Greenville, SC (United States); Dixit, V.B.; Lisauskas, R.A. [Riley Stoker Corp., Worcester, MA (United States); Johnson, S.A. [PSI Technology Co., Andover, MA (United States). PowerServe Div.

1994-10-01T23:59:59.000Z

443

OPSAID improvements and capabilities report.  

SciTech Connect

Process Control System (PCS) and Industrial Control System (ICS) security is critical to our national security. But there are a number of technological, economic, and educational impediments to PCS owners implementing effective security on their systems. Sandia National Laboratories has performed the research and development of the OPSAID (Open PCS Security Architecture for Interoperable Design), a project sponsored by the US Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE), to address this issue. OPSAID is an open-source architecture for PCS/ICS security that provides a design basis for vendors to build add-on security devices for legacy systems, while providing a path forward for the development of inherently-secure PCS elements in the future. Using standardized hardware, a proof-of-concept prototype system was also developed. This report describes the improvements and capabilities that have been added to OPSAID since an initial report was released. Testing and validation of this architecture has been conducted in another project, Lemnos Interoperable Security Project, sponsored by DOE/OE and managed by the National Energy Technology Laboratory (NETL).

Halbgewachs, Ronald D.; Chavez, Adrian R.

2011-08-01T23:59:59.000Z

444

An Improved Cluster Richness Estimator  

Science Conference Proceedings (OSTI)

Minimizing the scatter between cluster mass and accessible observables is an important goal for cluster cosmology. In this work, we introduce a new matched filter richness estimator, and test its performance using the maxBCG cluster catalog. Our new estimator significantly reduces the variance in the L{sub X}-richness relation, from {sigma}{sub lnL{sub X}}{sup 2} = (0.86 {+-} 0.02){sup 2} to {sigma}{sub lnL{sub X}}{sup 2} = (0.69 {+-} 0.02){sup 2}. Relative to the maxBCG richness estimate, it also removes the strong redshift dependence of the richness scaling relations, and is significantly more robust to photometric and redshift errors. These improvements are largely due to our more sophisticated treatment of galaxy color data. We also demonstrate the scatter in the L{sub X}-richness relation depends on the aperture used to estimate cluster richness, and introduce a novel approach for optimizing said aperture which can be easily generalized to other mass tracers.

Rozo, Eduardo; /Ohio State U.; Rykoff, Eli S.; /UC, Santa Barbara; Koester, Benjamin P.; /Chicago U. /KICP, Chicago; McKay, Timothy; /Michigan U.; Hao, Jiangang; /Michigan U.; Evrard, August; /Michigan U.; Wechsler, Risa H.; /SLAC; Hansen, Sarah; /Chicago U. /KICP, Chicago; Sheldon, Erin; /New York U.; Johnston, David; /Houston U.; Becker, Matthew R.; /Chicago U. /KICP, Chicago; Annis, James T.; /Fermilab; Bleem, Lindsey; /Chicago U.; Scranton, Ryan; /Pittsburgh U.

2009-08-03T23:59:59.000Z

445

Method to improve superconductor cable  

DOE Patents (OSTI)

A method is disclosed of making a stranded superconductor cable having improved flexing and bending characteristics. In such method, a plurality of superconductor strands are helically wound around a cylindrical portion of a mandrel which tapers along a transitional portion to a flat end portion. The helically wound strands form a multistrand hollow cable which is partially flattened by pressure rollers as the cable travels along the transitional portion. The partially flattened cable is impacted with repeated hammer blows as the hollow cable travels along the flat end portion. The hammer blows flatten both the internal and the external surfaces of the strands. The cable is fully flattened and compacted by two sets of pressure rollers which engage the flat sides and the edges of the cable after it has traveled away from the flat end portion of the mandrel. The flattened internal surfaces slide easily over one another when the cable is flexed or bent so that there is very little possibility that the cable will be damaged by the necessary flexing and bending required to wind the cable into magnet coils.

Borden, A.R.

1984-03-08T23:59:59.000Z

446

Evaluation of National Seismograph Network detection capabilities. Annual report, July 1994--July 1995: Volume 1  

Science Conference Proceedings (OSTI)

This first annual report presents detection thresholds and probabilities, and location error ellipse projects for the United States National Seismic Network (USNSN) with and without cooperative stations in the eastern US. Network simulation methods are used with spectral noise levels at stations to simulate the processes of excitation, propagation, detection, and processing of seismic phases. USNSN alone should be capable of detecting 4 or more P waves for shallow crustal earthquakes in nearly all the eastern and central US at magnitude 3.8 level. When cooperative stations are added, the network should be able to detect 4 or more P waves from events 0.2 to 0.3 magnitude units lower. Planned expansion of USNSN and cooperative stations should improve detection levels by an additional 0.2-0.3 magnitudes units in many areas. Location uncertainties for USNSN can be improved by adding real-time cooperative stations. Median error ellipses for magnitude 4.5 earthquakes depend strongly on location, but uncertainties should be less than 100 km{sup 2} in the central US and degrade to 200 km{sup 2} or more offshore and sosuth and north of the international boundaries. Close cooperation with the Canadian National Network should substantially improve detection thresholds and location uncertainties along the Canadian border.

McLaughlin, K.L.; Bennett, T.J. [S-Cubed, La Jolla, CA (United States)

1996-03-01T23:59:59.000Z

447

Potential improvements in materials accounting for an internationally safeguarded fuels reprocessing plant  

Science Conference Proceedings (OSTI)

The effectiveness of improved materials accounting was evaluated using computer modeling, simulation, and analysis techniques for two model reprocessing plants. One plant, sized to 210 MTHM/yr, represents the small plants currently under international safeguards and the other, sized to 1500 MTHM/yr, represents the large plants expected in the future. The study indicates that conventional accounting may meet IAEA goal quantities and detection times for low-enriched uranium in these facilities. Dynamic materials accounting can meet the IAEA goal for detecting abrupt (1 to 3 wk) diversion of 8 kg of plutonium. Current materials accounting techniques probably cannot meet the protracted diversion goal of detecting 8 kg for plutonium in 1 yr. Facility design features that can improve the effectiveness of materials accounting in future plants are discussed.

Hakkila, E.A.; Dayem, H.A.; Cobb, D.D.; Dietz, R.J.; Shipley, J.P.

1980-01-01T23:59:59.000Z

448

Economic Improvement Districts (Indiana) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Improvement Districts (Indiana) Improvement Districts (Indiana) Economic Improvement Districts (Indiana) < Back Eligibility Agricultural Commercial Construction Fuel Distributor Industrial Installer/Contractor Investor-Owned Utility Local Government Municipal/Public Utility Retail Supplier Rural Electric Cooperative State/Provincial Govt Systems Integrator Transportation Tribal Government Utility Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Indiana Program Type Bond Program Industry Recruitment/Support Provider Indiana Economic Development Corporation A legislative body may adopt an ordinance establishing an economic improvement district and an Economic Improvement Board to manage development in a respective district. The Board can choose to issue revenue

449

Cancer in atomic bomb survivors  

SciTech Connect

Radiation carcinogenesis was first noted in studies of individuals with occupational or therapeutic exposure to radiation. Data from long-term follow-up studies of atomic bomb survivors in Hiroshima and Nagasaki have greatly enhanced our knowledge of radiation carcinogenesis. This book presents current results obtained from epidemiological studies and pathological studies on cancer among atomic bomb survivors. It includes a description of the dosimetry system which is currently being revised. Although many of the details about radiation carcinogenesis remain unknown or uncertain, it is clear that the incidence of radiation-induced cancer among atomic bomb survivors continues unabated 40 years after exposure. Recent increases in occupational and environmental exposure to radiation together with the need for a thorough review of radiation protection standards have led to increased recognition of the importance of research on radiation carcinogenesis and risk assessment.

Shigematsu, I.; Kagan, A.

1986-01-01T23:59:59.000Z

450

Air pollution and lung cancer  

SciTech Connect

Epidemiological evidence proves conclusively that lung cancer correlates with air pollution. However, data on lung cancer death rates and smoking show that mankind accepts the risk of long-term and low-level exposure to carcinogens. As a rule, immediate benefits are sought and remote hazards ignored. Fear of atmospheric contamination by radioactive fallout seems to be the main factor for awareness of air pollution. Experimental works help us to understand physics of particle deposition in the lungs (inertial impactation, sedimentation, Brownian movement), shed light on carcinogenesis (eg, bay region theory in case of polycyclic aromatic hydrocarbons and surface charge changes regarding asbestos), show that atmospheric particulates accepted as harmless may act as co-carcinogens (eg, iron and benzo(a)pyrene) and stress the importance of in vitro research (bacterial mutation tests, organ cultures, sister chromatid exchange system) to screen pollutants for their malignant potential and study their pathogenesis.

Boehm, G.M.

1982-01-01T23:59:59.000Z

451

The possibility of detecting planets in the Andromeda Galaxy  

E-Print Network (OSTI)

The Angstrom Project is using a global network of 2m-class telescopes to conduct a high cadence pixel microlensing survey of the bulge of the Andromeda Galaxy (M31), with the primary aim of constraining its underlying bulge mass distribution and stellar mass function. Here we investigate the feasibility of using such a survey to detect planets in M31. We estimate the efficiency of detecting signals for events induced by planetary systems as a function of planet/star mass ratio and separation, source type and background M31 surface brightness. We find that for planets of a Jupiter-mass or above that are within the lensing zone (~1 -3 AU) detection is possible above 3 $\\sigma$, with detection efficiencies ~3% for events associated with giant stars, which are the typical source stars of pixel-lensing surveys. A dramatic improvement in the efficiency of ~40 -- 60% is expected if follow-up observations on an 8m telescope are made possible by a real-time alert system.

Chung, S J; Darnley, M J; Duke, J P; Gould, A; Han, C; Jeon, Y B; Kerins, E; Newsam, A; Park, B G

2005-01-01T23:59:59.000Z

452

Detecting Chiral Edge States in the Hofstadter Optical Lattice  

E-Print Network (OSTI)

We propose a realistic scheme to detect topological edge states in an optical lattice subjected to a synthetic magnetic field, based on a generalization of Bragg spectroscopy sensitive to angular momentum. We demonstrate that using a well-designed laser probe, the Bragg spectra provide an unambiguous signature of the topological edge states that establishes their chiral nature. This signature is present for a variety of boundaries, from a hard wall to a smooth harmonic potential added on top of the optical lattice. Experimentally, the Bragg signal should be very weak. To make it detectable, we introduce a "shelving method", based on Raman transitions, which transfers angular momentum and changes the internal atomic state simultaneously. This scheme allows to detect the weak signal from the selected edge states on a dark background, and drastically improves the detectivity. It also leads to the possibility to directly visualize the topological edge states, using in situ imaging, offering a unique and instructive view on topological insulating phases.

Nathan Goldman; Jerome Beugnon; Fabrice Gerbier

2012-03-06T23:59:59.000Z

453

Radiation detection and situation management by distributed sensor networks  

Science Conference Proceedings (OSTI)

Detection of radioactive materials in an urban environment usually requires large, portal-monitor-style radiation detectors. However, this may not be a practical solution in many transport scenarios. Alternatively, a distributed sensor network (DSN) could complement portal-style detection of radiological materials through the implementation of arrays of low cost, small heterogeneous sensors with the ability to detect the presence of radioactive materials in a moving vehicle over a specific region. In this paper, we report on the use of a heterogeneous, wireless, distributed sensor network for traffic monitoring in a field demonstration. Through wireless communications, the energy spectra from different radiation detectors are combined to improve the detection confidence. In addition, the DSN exploits other sensor technologies and algorithms to provide additional information about the vehicle, such as its speed, location, class (e.g. car, truck), and license plate number. The sensors are in-situ and data is processed in real-time at each node. Relevant information from each node is sent to a base station computer which is used to assess the movement of radioactive materials.

Jan, Frigo [Los Alamos National Laboratory; Mielke, Angela [Los Alamos National Laboratory; Cai, D Michael [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

454

Receiver Operating Characteristic Analysis for Detecting Explosives-related Threats  

SciTech Connect

The Department of Homeland Security (DHS) and the Transportation Security Administration (TSA) are interested in developing a standardized testing procedure for determining the performance of candidate detection systems. This document outlines a potential method for judging detection system performance as well as determining if combining the information from a legacy system with a new system can signi��������cantly improve performance. In this document, performance corresponds to the Neyman-Pearson criterion applied to the Receiver Operating Characteristic (ROC) curves of the detection systems in question. A simulation was developed to investigate how the amount of data provided by the vendor in the form of the ROC curve e�������¤ects the performance of the combined detection system. Furthermore, the simulation also takes into account the potential e�������¤ects of correlation and how this information can also impact the performance of the combined system.

Mark E. Oxley; Alexander M. Venzin

2012-11-14T23:59:59.000Z

455

Web Improvement Strategy | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Web Improvement Strategy Web Improvement Strategy Web Improvement Strategy Objective: Improve Digital Communications While Eliminating Wasteful Spending In June 2011, the Obama Administration launched the Campaign to Cut Waste, an effort to root out wasteful spending at every agency and department in the Federal government, and highlighted Federal Web Reform as a key part of the initiative. Since the Energy Department owns hundreds of websites -- about 87 domains and hundreds of subdomains -- we're answering the Administration's call, seizing the opportunity to streamline web operations, reduce duplicative spending and improve overall web communications. EnergyDepartmentWebImprovementStrategy.pdf 10_13_2011WebImprovementStrategy_0.docx More Documents & Publications Department of Energy Customer Service Plan

456

Key Findings and Recommendations for Improvement NIST ...  

Science Conference Proceedings (OSTI)

... heat detection/fire alarm system was installed in the ... b) increasing the capacity of the ... eliminating trade-offs between sprinkler installation and factors ...

2011-08-15T23:59:59.000Z

457

Using Dashboards to Improve Energy and Comfort in Federal Buildings  

SciTech Connect

Federal agencies are taking many steps to improve the sustainability of their operations, including improving the energy efficiency of their buildings, promoting recycling and reuse of materials, encouraging carpooling and alternative transit schemes, and installing low flow water fixture units are just a few of the common examples. However, an often overlooked means of energy savings is to provide feedback to building users about their energy use through information dashboards connected to a building?s energy information system. An Energy Information System (EIS), broadly defined, is a package of performance monitoring software, data acquisition hardware, and communication systems that is used to collect, store, analyze, and display energy information. At a minimum, the EIS provides the whole-building energy-use information (Granderson 2009a). We define a ?dashboard? as a display and visualization tool that utilizes the EIS data and technology to provide critical information to users. This information can lead to actions resulting in energy savings, comfort improvements, efficient operations, and more. The tools to report analyzed information have existed in the information technology as business intelligence (Few 2006). The dashboard is distinguished from the EIS as a whole, which includes additional hardware and software components to collect and storage data, and analysis for resources and energy management (Granderson 2009b). EIS can be used for a variety of uses, including benchmarking, base-lining, anomaly detection, off-hours energy use evaluation, load shape optimization, energy rate analysis, retrofit and retro-commissioning savings (Granderson 2009a). The use of these EIS features depends on the specific users. For example, federal and other building managers may use anomaly detection to identify energy waste in a specific building, or to benchmark energy use in similar buildings to identify energy saving potential and reduce operational cost. There are several vendors of EIS technology that provide information on energy and other environmental variables in buildings.

Lawrence Berkeley National Laboratory; Marini, Kyle; Ghatikar, Girish; Diamond, Richard

2011-02-01T23:59:59.000Z

458

Detection of CO sub 2 -induced climatic change  

SciTech Connect

In spite of the strong circumstantial evidence that the greenhouse effect has contributed significantly to the observed global warming, we are still unable to state unequivocally that the effect has been detected. Either we must eliminate all other possibilities, or we must identify one or more multivariate characteristics of the observed changes in climate that are unique signature of the greenhouse effect. We propose to continue earlier work in five areas: Updating, improvement and analysis of our global (land and marine) temperature data set, The development and use of multivariate techniques for the detection of greenhouse-gas-induced climatic change, The further development and use of simple transient-response climate models in order to elucidate the responses of the climate system to external and internal forcing, Validation of General Circulation Models using a variety of test statistics, and The use of regression methods to produce sub-grid-scale information from GCM output. 63 refs., 2 figs., 1 tab.

Wigley, T.M.L.

1990-07-15T23:59:59.000Z

459

Detection of greenhouse-gas-induced climatic change  

SciTech Connect

The aims of the US Department of Energy's Carbon Dioxide Research Program are to improve assessments of greenhouse-gas-induced climatic change and to define and reduce uncertainties through selected research. This project will address: The regional and seasonal details of the expected climatic changes; how rapidly will these changes occur; how and when will the climatic effects of CO[sub 2] and other greenhouse gases be first detected; and the relationships between greenhouse-gas-induced climatic change and changes caused by other external and internal factors. The present project addresses all of these questions. Many of the diverse facets of greenhouse-gas-related climate research can be grouped under three interlinked subject areas: modeling, first detection and supporting data. This project will include the analysis of climate forcing factors, the development and refinement of transient response climate models, and the use of instrumental data in validating General Circulation Models (GCMs).

Wigley, T.M.L.; Jones, P.D.

1992-07-15T23:59:59.000Z

460

Detection of Tool Flute Breakage in End Milling Using Feed-Motor Current Signatures  

E-Print Network (OSTI)

In this paper, an effective algorithm based on improved time-domain averaging is proposed to detect tool flute breakage during end milling using feed-motor current signatures. The algorithm proposed is demonstrated to be effective in detecting tool flute breakage in real time through a series of milling experiments, and is also demonstrated to be insensitive to the effects for transients, such as cutter runout, entry/exit cuts, and noise in the feed-motor current signals. Results indicated that the approach showed excellent potential for practical, on-line application for tool flute breakage detection during end milling.

Xiao Li

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Ultra-low field MRI of prostate cancer using SQUID detection  

E-Print Network (OSTI)

current couples a flux ? s into the SQUID, which is directly related to the applied fieldFlux transformers pulsed magnetic fields. This current-fields, like those used in an NMR experiment, that could potentially trap flux in the SQUID causing a lower critical current and

Busch, Sarah Elizabeth

2011-01-01T23:59:59.000Z

462

Autofluorescence detection and imaging of bladder cancer realized through a cystoscope  

DOE Patents (OSTI)

Near infrared imaging using elastic light scattering and tissue autofluorescence and utilizing interior examination techniques and equipment are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and/or tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

Demos, Stavros G. (Livermore, CA); deVere White, Ralph W. (Sacramento, CA)

2007-08-14T23:59:59.000Z

463

Computational methods for analyzing and detecting genomic structural variation : applications to cancer  

E-Print Network (OSTI)

of integrating CGH and ESP data into a ?ow problem. . . . .integrating arrayCGH and ESP. Personal Communi- cation. [End-Sequence Pro?ling (ESP) and Paired-end Mapping (PEM)

Bashir, Ali

2009-01-01T23:59:59.000Z

464

Anatomy-Based Algorithms for Detecting Oral Cancer Using Reflectance and Fluorescence Spectroscopy  

E-Print Network (OSTI)

OBJECTIVES: We used reflectance and fluorescence spectroscopy to noninvasively and quantitatively distinguish benign from dysplastic/malignant oral lesions. We designed diagnostic algorithms to account for differences in ...

McGee, Sasha

465

Detection and characterization of translational research in cancer and cardiovascular medicine  

E-Print Network (OSTI)

Background: Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions ...

Cambrosio, Alberto

466

Ultra-low field MRI of prostate cancer using SQUID detection  

E-Print Network (OSTI)

path is interrupted by a weak link (known as a Josephson? 2 is allowed across the weak link [13]. The dc Josephson

Busch, Sarah Elizabeth

2011-01-01T23:59:59.000Z

467

Radiation Detection Computational Benchmark Scenarios  

SciTech Connect

Modeling forms an important component of radiation detection development, allowing for testing of new detector designs, evaluation of existing equipment against a wide variety of potential threat sources, and assessing operation performance of radiation detection systems. This can, however, result in large and complex scenarios which are time consuming to model. A variety of approaches to radiation transport modeling exist with complementary strengths and weaknesses for different problems. This variety of approaches, and the development of promising new tools (such as ORNL’s ADVANTG) which combine benefits of multiple approaches, illustrates the need for a means of evaluating or comparing different techniques for radiation detection problems. This report presents a set of 9 benchmark problems for comparing different types of radiation transport calculations, identifying appropriate tools for classes of problems, and testing and guiding the development of new methods. The benchmarks were drawn primarily from existing or previous calculations with a preference for scenarios which include experimental data, or otherwise have results with a high level of confidence, are non-sensitive, and represent problem sets of interest to NA-22. From a technical perspective, the benchmarks were chosen to span a range of difficulty and to include gamma transport, neutron transport, or both and represent different important physical processes and a range of sensitivity to angular or energy fidelity. Following benchmark identification, existing information about geometry, measurements, and previous calculations were assembled. Monte Carlo results (MCNP decks) were reviewed or created and re-run in order to attain accurate computational times and to verify agreement with experimental data, when present. Benchmark information was then conveyed to ORNL in order to guide testing and development of hybrid calculations. The results of those ADVANTG calculations were then sent to PNNL for compilation. This is a report describing the details of the selected Benchmarks and results from various transport codes.

Shaver, Mark W.; Casella, Andrew M.; Wittman, Richard S.; McDonald, Ben S.

2013-09-24T23:59:59.000Z

468

automated improvement of radiation therapy treatment plans by ...  

E-Print Network (OSTI)

The research was supported by the Swedish Research Council ... dimensional conformal radiotherapy and IMRT for adjuvant chemoradiation for gastric cancer.

469

COMPACT CdZnTe-BASED GAMMA CAMERA FOR PROSTATE CANCER IMAGING  

SciTech Connect

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.

CUI, Y.; LALL, T.; TSUI, B.; YU, J.; MAHLER, G.; BOLOTNIKOV, A.; VASKA, P.; DeGERONIMO, G.; O' CONNOR, P.; MEINKEN, G.; JOYAL, J.; BARRETT, J.; CAMARDA, G.; HOSSAIN, A.; KIM, K.H.; YANG, G.; POMPER, M.; CHO, S.; WEISMAN, K.; SEO, Y.; BABICH, J.; LaFRANCE, N.; AND JAMES, R.B.

2011-10-23T23:59:59.000Z

470

Fire suppression and detection equipment  

SciTech Connect

Inspection and testing guidelines go beyond the 'Code of Federal Regulation'. Title 30 of the US Code of Federal Regulations (30 CFR) contains requirements and references to national standards for inspection, testing and maintenance of fire suppression and detection equipment for mine operators. However, federal requirements have not kept pace with national standards and best practices. The article lists National Fire Protection (NFPA) standards that are referenced by the US Mine Safety and Health Administration (MSHA) in 30 CFR. It then discusses other NFPA Standards excluded from 30 CFR and explains the NFPA standard development process. 2 refs., 3 tabs., 5 photos.

E.E. Bates [HSB Professional Loss Control, Lexington, KY (United States)

2006-01-15T23:59:59.000Z

471

Multiplex detection of respiratory pathogens  

SciTech Connect

Described are kits and methods useful for detection of respiratory pathogens (influenza A (including subtyping capability for H1, H3, H5 and H7 subtypes) influenza B, parainfluenza (type 2), respiratory syncytial virus, and adenovirus) in a sample. Genomic sequence information from the respiratory pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample.

McBride, Mary (Brentwood, CA); Slezak, Thomas (Livermore, CA); Birch, James M. (Albany, CA)

2012-07-31T23:59:59.000Z

472

OpenEI:Projects/Datasets Improvements | Open Energy Information  

Open Energy Info (EERE)

Improvements Improvements Jump to: navigation, search Contents 1 Purpose 2 Discussions on Feb 22, 2011 2.1 Longer-term Changes 2.2 Near-term Modifications to Metadata 3 Suggestions from Jan 13, 2011 3.1 Specific Changes to Metadata Fields (part of 'upload data' experience) 3.1.1 Fields as Links (rather than strings) 3.1.2 Multiple Fields 3.1.3 Data Upload Links 3.1.4 Remove 'Order' for Multiple Fields 3.2 Specific Recommendations for Improving/Expanding Metadata Fields 3.2.1 Flexible Properties/Metadata Fields 3.2.2 Wizard Flows for Common File Types 3.3 New Aspects of Datasets 3.3.1 Duplication/Relationship Detection 3.3.2 Wiki-Style Metadata 3.3.3 New Dataset 'Type': Translation (?) 3.3.4 Relationships/Similarities 4 Errors/Issues (uploading datasets) Purpose Evaluate current user-experience (for uploading, browsing, and

473

Clean Diesel Component Improvement Program  

DOE Green Energy (OSTI)

The research conducted in this program significantly increased the knowledge and understanding in the fields of plasma physics and chemistry in diesel exhaust, the performance and characteristics of multifunctional catalysts in diesel exhaust, and the complexities of controlling a combination of such systems to remove NOx. Initially this program was designed to use an in-line plasma system (know as a plasma assisted catalyst system or PAC) to convert NO {yields} NO{sub 2}, a more catalytically active form of nitrogen oxides, and to crack hydrocarbons (diesel fuel in particular) into active species. The NO{sub 2} and the cracked hydrocarbons were then flowed over an in-line ceramic NOx catalyst that removed NO{sub 2} from the diesel exhaust. Even though the PAC system performed well technically and was able to remove over 95% of NOx from diesel exhaust the plasma component proved not to be practical or commercially feasible. The lack of practical and commercial viability was due to high unit costs and lack of robustness. The plasma system and its function was replaced in the NOx removal process by a cracking reforming catalyst that converted diesel fuel to a highly active reductant for NOx over a downstream ceramic NOx catalyst. This system was designated the ceramic catalyst system (CCS). It was also determined that NO conversion to NO{sub 2} was not required to achieve high levels of NOx reduction over ceramic NOx catalyst if that catalyst was properly formulated and the cracking reforming produced a reductant optimized for that NOx catalyst formulation. This system has demonstrated 92% NOx reduction in a diesel exhaust slipstream and 65% NOx reduction from the full exhaust of a 165 hp diesel engine using the FTP cycle. Although this system needs additional development to be commercial, it is simple, cost effective (does not use precious metals), sulfur tolerant, operates at high space velocities, does not require a second fluid be supplied as a reductant, has low parasitic loss of 2-3% and achieves high levels of NOx reduction. This project benefits the public by providing a simple low-cost technology to remove NOx pollutants from the exhaust of almost any combustion source. The reduction of NOx emissions emitted into the troposphere provides well documented improvement in health for the majority of United States citizens. The emissions reduction produced by this technology helps remove the environmental constraints to economic growth.

None

2005-06-30T23:59:59.000Z

474

Energy Efficiency Improvement in the Petroleum Refining Industry  

E-Print Network (OSTI)

boiler improvements, steam distribution, heat exchangers,pinch analys