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they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system  

DOE Patents [OSTI]

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Kieper, Douglas Arthur (Seattle, WA); Majewski, Stanislaw (Morgantown, WV); Welch, Benjamin L. (Hampton, VA)

2012-07-03T23:59:59.000Z

2

Method to improve cancerous lesion detection sensitivity in a dedicated dual-head scintimammography system  

DOE Patents [OSTI]

An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

Kieper, Douglas Arthur (Newport News, VA); Majewski, Stanislaw (Yorktown, VA); Welch, Benjamin L. (Hampton, VA)

2008-10-28T23:59:59.000Z

3

AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER  

E-Print Network [OSTI]

AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER Marius George LINGURARU, Oxford OX2 7BZ, United Kingdom mglin@robots.ox.ac.uk Abstract: The prevalence of breast cancer must provide effective clinical methods to detect cancer and improve life expectancy. Considerable

Paris-Sud XI, Université de

4

Detecting Discrepancies and Improving Intelligibility  

E-Print Network [OSTI]

Detecting Discrepancies and Improving Intelligibility: Two Preliminary Evaluations of RIPTIDES evaluations of RIPTIDES, a sys- tem that combines information extraction (IE), extraction-based sum unduly sacrificing content relevance. 1 Introduction We report on two preliminary evaluations of RIPTIDES

Wagstaff, Kiri L.

5

Early Lung Cancer Detection Program  

Broader source: Energy.gov [DOE]

Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

6

Improving the detection ...1 Improving the detection of On-line Vertical Port Scan  

E-Print Network [OSTI]

Improving the detection ...1 Improving the detection of On-line Vertical Port Scan Improving the detection of On-line Vertical Port Scan in IP Traffic Yousra Chabchoub , Christine Fricker and Philippe to detect port scan attacks in IP traffic. Only relevant information about destination IP addresses

Paris-Sud XI, Université de

7

Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam  

E-Print Network [OSTI]

Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

Petta, Jason

8

Nanotechnology in Cancer Treatment and Detection Richard Acosta  

E-Print Network [OSTI]

Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation ·Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

Fygenson, Deborah Kuchnir

9

Improved Microseismicity Detection During Newberry EGS Stimulations  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Templeton, Dennise

10

Improved Microseismicity Detection During Newberry EGS Stimulations  

SciTech Connect (OSTI)

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Templeton, Dennise

2013-11-01T23:59:59.000Z

11

Improved Microseismicity Detection During Newberry EGS Stimulations  

SciTech Connect (OSTI)

Effective enhanced geothermal systems (EGS) require optimal fracture networks for efficient heat transfer between hot rock and fluid. Microseismic mapping is a key tool used to infer the subsurface fracture geometry. Traditional earthquake detection and location techniques are often employed to identify microearthquakes in geothermal regions. However, most commonly used algorithms may miss events if the seismic signal of an earthquake is small relative to the background noise level or if a microearthquake occurs within the coda of a larger event. Consequently, we have developed a set of algorithms that provide improved microearthquake detection. Our objective is to investigate the microseismicity at the DOE Newberry EGS site to better image the active regions of the underground fracture network during and immediately after the EGS stimulation. Detection of more microearthquakes during EGS stimulations will allow for better seismic delineation of the active regions of the underground fracture system. This improved knowledge of the reservoir network will improve our understanding of subsurface conditions, and allow improvement of the stimulation strategy that will optimize heat extraction and maximize economic return.

Templeton, Dennise

2013-10-01T23:59:59.000Z

12

Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer  

E-Print Network [OSTI]

Pretargeted radioimmunotherapy (PRIT) of cancer improves upon conventional radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have ...

Zajic, Stefan C

2007-01-01T23:59:59.000Z

13

E-Print Network 3.0 - advanced cancer detection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: advanced cancer detection Page: << < 1 2 3 4 5 > >> 1 The Cancer Risk Clinic Cancer Risk Clinical...

14

Nested methylation-specific polymerase chain reaction cancer detection method  

DOE Patents [OSTI]

A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

2007-05-08T23:59:59.000Z

15

Improving tamper detection for hazardous waste security  

SciTech Connect (OSTI)

After September 11, waste managers are increasingly expected to provide improved levels of security for the hazardous materials in their charge. Many low-level wastes that previously had minimal or no security must now be well protected, while high-level wastes require even greater levels of security than previously employed. This demand for improved security comes, in many cases, without waste managers being provided the necessary additional funding, personnel, or security expertise. Contributing to the problem is the fact that--at least in our experience--waste managers often fail to appreciate certain types of security vulnerabilities. They frequently overlook or underestimate the security risks associated with disgruntled or compromised insiders, or the potential legal and political liabilities associated with nonexistent or ineffective security. Also frequently overlooked are potential threats from waste management critics who could resort to sabotage, vandalism, or civil disobedience for purposes of discrediting a waste management program.

Johnston, R. G. (Roger G.); Garcia, A. R. E. (Anthony R. E.); Pacheco, A. N. (Adam N.); Trujillo, S. J. (Sonia J.); Martinez, R. K. (Ronald K.); Martinez, D. D. (Debbie D.); Lopez, L. N. (Leon N.)

2002-01-01T23:59:59.000Z

16

IMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES  

E-Print Network [OSTI]

that automatically detects suspicious behavior analyzing customers historical consumption curve. Thus, UTE's expertsIMPROVING ELECTRIC FRAUD DETECTION USING CLASS IMBALANCE STRATEGIES Mat´ias Di Martino, Federico, jmolinelli}@gmail.com Keywords: Electricity theft, Support vector machine, Optimum path forest, Unbalance

17

Estimating distribution of the age of onset of detectable asymptomatic cancer  

E-Print Network [OSTI]

Estimating distribution of the age of onset of detectable asymptomatic cancer Giovanni Parmigiani through the Specialized Program of Research Ex­ cellence (SPORE) grant in Breast Cancer at Duke University to estimate the distribution of the age of onset of detectable preclinical cancer, using incidence data

West, Mike

18

The Role of Fucose in Early Cancer Detection  

E-Print Network [OSTI]

t r o s p r a y ionization mass s p e c t r o m e t r y (ESI-MS); samples were ionized with 10 mM ammonium acetate in positive ion mode and detected by the spectrometer. This ionization produced the charge state [M+NH 4 ]+. To ensure accuracy...THE JOURNAL OF UNDERGRADUATE RESEARCH University of Kansas | Fall 2009 63 JEFF HEINZMAN, DAVID MCKENZIE, SCOTT MELROSE, PATRICK SELLEY & JAMIE WENKE are all seniors in Chemistry at the University of Kansas. The Role of Fucose in Early Cancer...

Heinzman, Jeff; McKenzie, David; Melrose, Scott; Selley, Patrick; Wenke, Jamie

2009-10-01T23:59:59.000Z

19

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision  

E-Print Network [OSTI]

Improved Cancer Risk Assessment Using Text Mining Name Mode of Action Precision Aflatoxin B1 for risk assessment purposes Cancer Risk Assessment examines existing scientific evidence to determine the relationship between exposure to a chemical and the likelihood of developing cancer from that exposure. Text

Korhonen, Anna

20

Bonus-- Cameras Designed To Strengthen Nuclear Security Can Also Detect Cancer  

Broader source: Energy.gov [DOE]

Thanks to researchers from Brookhaven National Laboratory, a high-resolution gamma camera exists that can be used to detect prostate cancer.

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Improving Credit Card Fraud Detection using a Meta- Classification Strategy  

E-Print Network [OSTI]

One of the issues facing credit card fraud detection systems is that a significant percentage of transactions labeled as fraudulent are in fact legitimate. These false alarms delay the detection of fraudulent transactions and can cause unnecessary concerns for customers. In this study, over 1 million unique credit card transactions from 11 months of data from a large Canadian bank were analyzed. A meta-classifier model was applied to the transactions after being analyzed by the Banks existing neural network based fraud detection algorithm. This meta-classifier model consists of 3 base classifiers constructed using the decision tree, nave Bayesian, and k-nearest neighbour algorithms. The nave Bayesian algorithm was also used as the meta-level algorithm to combine the base classifier predictions to produce the final classifier. Results from the research show that when a metaclassifier was deployed in series with the Banks existing fraud detection algorithm improvements of up to 28 % to their existing system can be achieved.

Joseph Pun; Yuri Lawryshyn

22

Microwave imaging for ultra-wideband antenna based cancer detection  

E-Print Network [OSTI]

Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

Zhang, Haoyu

2015-06-29T23:59:59.000Z

23

Improvements to Existing Transit Detection Algorithms and Their Comparison  

E-Print Network [OSTI]

In Tingley (2003), all available transit detection algorithms were compared in a simple, rigorous test. However, the implementation of the Box-fitting Least Squares (BLS) approach of Kovacs et al. (2002) used in that paper was not ideal for those purposes. This letter revisits the comparison, using a version of the BLS better suited to the task at hand and made more efficient via the knowledge gained from the previous work. Multiple variations of the BLS and the matched filter are tested. Some of the modifications improve performance to such an extent that the conclusions of the original paper must be revised.

B. Tingley

2003-07-28T23:59:59.000Z

24

Algorithms for Detecting Significantly Mutated Pathways in Cancer  

E-Print Network [OSTI]

breast and colorectal cancers. Science 314(5797), 268­274 (2006) 37. Tsuda, K., Noble, W.S.: Learning.Y., Lee, E., Liu, Y.T., Lee, D., Ideker, T.: Network-based classification of breast cancer metastasis. Mol and colorectal cancers. Genome Res. 17, 1304­1318 (2007) 26. Liu, M., et al.: Network-based analysis of affected

Raphael, Ben J.

25

Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy  

E-Print Network [OSTI]

Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

Smith, Elizabeth Brooks

2009-05-15T23:59:59.000Z

26

Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer  

E-Print Network [OSTI]

Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13...

Chinna Balareddy, Karthik Reddy

2012-10-19T23:59:59.000Z

27

An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration  

E-Print Network [OSTI]

An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration J. L the success of geologic carbon sequestration projects. To detect subtle CO2 leakage signals, we present), An improved strategy to detect CO2 leakage for verification of geologic carbon sequestration, Geophys. Res

Hilley, George

28

A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing  

E-Print Network [OSTI]

The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue ...

Ghosh, Subrata K.

29

Supervised Machine Learning Algorithms for Early Detection of Oral Epithelial Cancer Using Fluorescence Lifetime Imaging Microscopy  

E-Print Network [OSTI]

In this study, the clinical potential of the endogenous multispectral Fluorescence lifetime imaging microscopy (FLIM) was investigated to objectively detect oral cancer. To this end, in vivo FLIM imaging was performed on a hamster cheek pouch model...

Lee, Joohyung

2014-08-06T23:59:59.000Z

30

Low-Dose Spiral CT Scans for Early Lung Cancer Detection  

Broader source: Energy.gov [DOE]

Low-dose spiral computed tomography (CT) scanning is a noninvasive medical imaging test that has been used for the early detection of lung cancer for over 16 years (Sone et al. 1998; Henschke et.al. 1999).

31

Method for detecting the presence of prostate cancer  

DOE Patents [OSTI]

The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

Karin, Michael; Luo, Jun-Li; Tan, Wei

2010-04-13T23:59:59.000Z

32

Improvements to a queue and delay estimation algorithm utilized in video imaging vehicle detection systems  

E-Print Network [OSTI]

Video Imaging Vehicle Detection Systems (VIVDS) are steadily becoming the dominant method for the detection of vehicles at a signalized traffic approach. This research is intended to investigate the improvement of a queue and delay estimation...

Cheek, Marshall Tyler

2007-09-17T23:59:59.000Z

33

Computerized detection of breast cancer on automated breast ultrasound imaging of women with dense breasts  

SciTech Connect (OSTI)

Purpose: Develop a computer-aided detection method and investigate its feasibility for detection of breast cancer in automated 3D ultrasound images of women with dense breasts. Methods: The HIPAA compliant study involved a dataset of volumetric ultrasound image data, views, acquired with an automated U-Systems SomoV{sup } ABUS system for 185 asymptomatic women with dense breasts (BI-RADS Composition/Density 3 or 4). For each patient, three whole-breast views (3D image volumes) per breast were acquired. A total of 52 patients had breast cancer (61 cancers), diagnosed through any follow-up at most 365 days after the original screening mammogram. Thirty-one of these patients (32 cancers) had a screening-mammogram with a clinically assigned BI-RADS Assessment Category 1 or 2, i.e., were mammographically negative. All software used for analysis was developed in-house and involved 3 steps: (1) detection of initial tumor candidates, (2) characterization of candidates, and (3) elimination of false-positive candidates. Performance was assessed by calculating the cancer detection sensitivity as a function of the number of marks (detections) per view. Results: At a single mark per view, i.e., six marks per patient, the median detection sensitivity by cancer was 50.0% (16/32) 6% for patients with a screening mammogram-assigned BI-RADS category 1 or 2similar to radiologists performance sensitivity (49.9%) for this dataset from a prior reader studyand 45.9% (28/61) 4% for all patients. Conclusions: Promising detection sensitivity was obtained for the computer on a 3D ultrasound dataset of women with dense breasts at a rate of false-positive detections that may be acceptable for clinical implementation.

Drukker, Karen, E-mail: kdrukker@uchicago.edu; Sennett, Charlene A.; Giger, Maryellen L. [Department of Radiology, MC2026, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)] [Department of Radiology, MC2026, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)

2014-01-15T23:59:59.000Z

34

An Improved Labelling for the INRIA Person Data Set for Pedestrian Detection  

E-Print Network [OSTI]

An Improved Labelling for the INRIA Person Data Set for Pedestrian Detection Matteo Taiana, Jacinto for comparing detection algorithms, fostering advances in the state of the art. The INRIA person data set, INRIA person data set, labelling 1 Introduction Detecting humans in images is a challenging task

35

Improvement of the New NO Detection Method Using  

E-Print Network [OSTI]

by impurities in the ionization cell by using a TOF mass spectrometer. The obtained sensitivity of this method. Sci. Instrum. 1997, 68, 2891). This method uses a frequency-doubled pulsed-dye laser operating near developed a new detection method for NO by using a pulsed-dye laser operating at near 226 nm to photoionize

Lee, Shan-Hu

36

Improved Lithium-Loaded Liquid Scintillators for Neutron Detection - Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching.348 270 300 219 255 135Detection System -

37

Detection of Ionizing Radiation by Plasma-Panel Sensors: Cosmic Muons, Ion Beams, and Cancer Therapy  

SciTech Connect (OSTI)

The plasma panel sensor is an ionizing photon and particle radiation detector derived from PDP technology with high gain and nanosecond response. Experimental results in detecting cosmic ray muons and beta particles from radioactive sources are described along with applications including high energy and nuclear physics, homeland security and cancer therapeutics.

Friedman, Dr. Peter S. [Integrated Sensors, LLC; Ferretti, Claudio [University of Michigan; Ball, Robert [University of Michigan; Beene, James R [ORNL; Ben Moshe, M. [Tel Aviv University; Benhammou, Yan [Tel Aviv University; Chapman, J. Wehrley [University of Michigan; Levin, Daniel S. [University of Michigan; Silver, Yiftah [Tel Aviv University; Weaverdyck, Curtis [University of Michigan; Zhou, Bing [University of Michigan; Etzion, E [Tel Aviv University; Moshe, M. [Tel Aviv University; Bentefour, E [Ion Beam Applications

2012-01-01T23:59:59.000Z

38

Neutron Imaging Explored as Complementary Technique for Improving...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron Imaging Explored as Complementary Technique for Improving Cancer Detection August 05, 2013 Researcher Maria Cekanova analyzes the neutron radiographs of a canine breast...

39

Detection of aldehydes in lung cancer cell culture by gas chromatography/mass spectrometry and solid-phase microextraction with on-fiber derivatization  

E-Print Network [OSTI]

of lung cancer. 2-4 A high level of aldehydes was found both in breath and blood of lung cancer patients. Acrolein was detected in blood from patients with breast cancer. 5 The formaldehyde level from women with breast cancer was higher than...

Shan, Guangqing

2007-09-17T23:59:59.000Z

40

Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts  

E-Print Network [OSTI]

at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

Kelly, KM; Dean, J; Comulada, WS; Lee, S-J

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Method for improving the limit of detection in a data signal  

DOE Patents [OSTI]

Disclosed is a method for improving the limit of detection for a data set in which experimental noise is uncorrelated along a given abscissa and an analytical signal is correlated to the abscissa, the steps comprising collecting the data set, converting the data set into a data signal including an analytical portion and the experimental noise portion, designating and adjusting a baseline of the data signal to center the experimental noise numerically about a zero reference, and integrating the data signal preserving the corresponding information for each point of the data signal. The steps of the method produce an enhanced integrated data signal which improves the limit of detection of the data signal. 8 figs.

Synovec, R.E.; Yueng, E.S.

1989-10-17T23:59:59.000Z

42

Improved methods for detecting gravitational waves associated with short gamma-ray bursts  

E-Print Network [OSTI]

In the era of second generation ground-based gravitational wave detectors, short gamma-ray bursts (GRBs) will be among the most promising astrophysical events for joint electromagnetic and gravitational wave observation. A targeted search for gravitational wave compact binary merger signals in coincidence with short GRBs was developed and used to analyze data from the first generation LIGO and Virgo instruments. In this paper, we present improvements to this search that enhance our ability to detect gravitational wave counterparts to short GRBs. Specifically, we introduce an improved method for estimating the gravitational wave background to obtain the event significance required to make detections; implement a method of tiling extended sky regions, as required when searching for signals associated to poorly localized GRBs from Fermi Gamma-ray Burst Monitor or the InterPlanetary Network; and incorporate astrophysical knowledge about the beaming of GRB emission to restrict the search parameter space. We descri...

Williamson, A R; Fairhurst, S; Harry, I W; Macdonald, E; Macleod, D; Predoi, V

2014-01-01T23:59:59.000Z

43

Breast Cancer Research Finding Answers. Finding Cures.  

E-Print Network [OSTI]

Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

Kowalczykowski, Stephen C.

44

The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells  

SciTech Connect (OSTI)

Expression of antibody fragments in mammalian cells (intrabodies) is used to probe the target protein or interfere with its biological function. We previously described the in vitro characterisation of a single-chain Fv (scFv) antibody fragment (F5) isolated from an intrabody library that binds to the oncoprotein gankyrin (GK) in solution. Here, we have isolated several other scFvs that interact with GK in the presence of F5 and tested whether they allow, when fused to fluorescent proteins, to detect by FRET endogenous GK in living cells. The binding of pairs of scFvs to GK was analysed by gel filtration and the ability of each scFv to mediate nuclear import/export of GK was determined. Binding between scFv-EGFP and RFP-labelled GK in living cells was detected by fluorescence lifetime imaging microscopy (FLIM). After co-transfection of two scFvs fused to EGFP and RFP, respectively, which form a tri-molecular complex with GK in vitro, FRET signal was measured. This system allowed us to observe that GK is monomeric and distributed throughout the cytoplasm and nucleus of several cancer cell lines. Our results show that pairs of fluorescently labelled intrabodies can be monitored by FLIMFRET microscopy and that this technique allows the detection of lowly expressed endogenous proteins in single living cells. Highlights: ? Endogenous GK in living cells was targeted with pairs of fluorescently-tagged scFvs. ? Tri-molecular complexes containing two scFvs and one molecule GK were formed. ? GK was detected using fluorescence lifetime-based FRET imaging. ? GK is monomeric and homogeneously distributed in several cancer cell lines. ? This technique may have many applications in live-cell imaging of endogenous proteins.

Rinaldi, Anne-Sophie; Freund, Guillaume; Desplancq, Dominique; Sibler, Annie-Paule; Baltzinger, Mireille [Ecole Suprieure de Biotechnologie de Strasbourg, UMR 7242, CNRS/Universit de Strasbourg, boulevard Sbastien Brant, 67412 Illkirch (France); Rochel, Natacha [Institut de Gntique et de Biologie Molculaire et Cellulaire, UMR 7104, CNRS/INSERM/Universit de Strasbourg, rue Laurent Fries, 67404 Illkirch (France); Mly, Yves; Didier, Pascal [Facult de Pharmacie, UMR 7213, CNRS/Universit de Strasbourg, route du Rhin, 67401 Illkirch (France); Weiss, Etienne, E-mail: eweiss@unistra.fr [Ecole Suprieure de Biotechnologie de Strasbourg, UMR 7242, CNRS/Universit de Strasbourg, boulevard Sbastien Brant, 67412 Illkirch (France)

2013-04-01T23:59:59.000Z

45

Improved methods for detecting gravitational waves associated with short gamma-ray bursts  

E-Print Network [OSTI]

In the era of second generation ground-based gravitational wave detectors, short gamma-ray bursts (GRBs) will be among the most promising astrophysical events for joint electromagnetic and gravitational wave observation. A targeted search for gravitational wave compact binary merger signals in coincidence with short GRBs was developed and used to analyze data from the first generation LIGO and Virgo instruments. In this paper, we present improvements to this search that enhance our ability to detect gravitational wave counterparts to short GRBs. Specifically, we introduce an improved method for estimating the gravitational wave background to obtain the event significance required to make detections; implement a method of tiling extended sky regions, as required when searching for signals associated to poorly localized GRBs from Fermi Gamma-ray Burst Monitor or the InterPlanetary Network; and incorporate astrophysical knowledge about the beaming of GRB emission to restrict the search parameter space. We describe the implementation of these enhancements and demonstrate how they improve the ability to observe binary merger gravitational wave signals associated with short GRBs.

A. R. Williamson; C. Biwer; S. Fairhurst; I. W. Harry; E. Macdonald; D. Macleod; V. Predoi

2014-10-22T23:59:59.000Z

46

Nanotechnology Alert. Nanofountain for Treatment of Cancer; Nanocomposites To Improve Computers' Life Span; Lithium Sulfur Batteries Using Nanocarbon  

E-Print Network [OSTI]

' Life Span; Lithium Sulfur Batteries Using Nanocarbon Electrodes This issue profiles a nanofountain, and lithium sulfur batteries that use nanocarbon electrodes. Deliverable Type: Technical Insights Date OF CANCER 3. NANOCOMPOSITES TO IMPROVE COMPUTERS LIFE SPAN 4. LITHIUM SULFUR BATTERIES USING NANOCARBON

Espinosa, Horacio D.

47

Phase-based x-ray scatteringA possible method to detect cancer cells in a very early stage  

SciTech Connect (OSTI)

Purpose: This theoretical work contains a detailed investigation of the potential and sensitivity of phase-based x-ray scattering for cancer detection in biopsies if cancer is in a very early stage of development. Methods: Cancer cells in their early stage of development differ from healthy ones mainly due to their faster growing cell nuclei and the enlargement of their densities. This growth is accompanied by an altered nucleusplasma relation for the benefit of the cell nuclei, that changes the physical properties especially the index of refraction of the cell and the one of the cell nuclei. Interaction of radiation with matter is known to be highly sensitive to small changes of the index of refraction of matter; therefore a detection of such changes of volume and density of cell nuclei by means of high angular resolved phase-based scattering of x rays might provide a technique to distinguish malignant cells from healthy ones ifthe cellcell nucleus system is considered as a coherent phase shifting object. Then one can observe from a thin biopsy which represents a monolayer of cells (no multiple scattering) that phase-based x-ray scattering curves from healthy cells differ from those of cancer cells in their early stage of development. Results: Detailed calculations of x-ray scattering patterns from healthy and cancer cell nuclei yield graphs and numbers with which one can distinguish healthy cells from cancer ones, taking into account that both kinds of cells occur in a tissue within a range of size and density. One important result is the role and the influence of the (lateral) coherence width of the radiation on the scattering curves and the sensitivity of phase-based scattering for cancer detection. A major result is that a larger coherence width yields a larger sensitivity for cancer detection. Further import results are calculated limits for critical sizes and densities of cell nuclei in order to attribute the investigated tissue to be healthy or diseased. Conclusions: With this proposed method it should be in principle possible to detect cancer cells in apparently healthy tissues in biopsies and/or in samples of the far border region of abscised or excised tissues. Thus this method could support established methods in diagnostics of cancer-suspicious samples.

Feye-Treimer, U., E-mail: feye-treimer@helmholtz-berlin.de; Treimer, W. [Department of Mathematics, Physics and Chemistry, University of Applied Sciences, D-13353 Berlin, Germany and Joint Department G-GTOMO, Helmholtz Zentrum fuer Materialien und Energie Berlin, D-14109 Berlin (Germany)] [Department of Mathematics, Physics and Chemistry, University of Applied Sciences, D-13353 Berlin, Germany and Joint Department G-GTOMO, Helmholtz Zentrum fuer Materialien und Energie Berlin, D-14109 Berlin (Germany)

2014-05-15T23:59:59.000Z

48

Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors  

E-Print Network [OSTI]

to investigating feasibility, we analyzed the potential for cardiovascular exercise dosing to have different effects on CVD and breast cancer risk factors including low VO2max and weight gain during an Energy Balance Program. Nineteen female breast cancer survivors...

Burnett, Dave

2013-05-31T23:59:59.000Z

49

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 52, NO. 7, JULY 2005 1237 Ultrawideband Microwave Breast Cancer Detection  

E-Print Network [OSTI]

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 52, NO. 7, JULY 2005 1237 Ultrawideband Microwave:1. Index Terms--Array signal processing, biomedical electromag- netic imaging, breast cancer detection-02-1-0625, the National Science Foundation under Grant BES 0201880, and the Graduate Engineering Research Scholars Program

Sheridan, Jennifer

50

Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)  

SciTech Connect (OSTI)

The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

Larson, S.M.; Finn, R.D.

1990-10-15T23:59:59.000Z

51

Dose critical in-vivo detection of anti-cancer drug levels in blood  

DOE Patents [OSTI]

A method and apparatus are disclosed for the in vivo and in vitro detection and measurement of dose critical levels of DNA-binding anti-cancer drug levels in biological fluids. The apparatus comprises a laser based fiber optic sensor (optrode) which utilizes the secondary interactions between the drug and an intercalating fluorochrome bound to a probe DNA, which in turn is attached to the fiber tip at one end thereof. The other end of the optical fiber is attached to an illumination source, detector and recorder. The fluorescence intensity is measured as a function of the drug concentration and its binding constant to the probe DNA. Anticancer drugs which lend themselves to analysis by the use of the method and the optrode of the present invention include doxorubicin, daunorubicin, carminomycin, aclacinomycin, chlorambucil, cyclophosphamide, methotrexate, 5-uracil, arabinosyl cytosine, mitomycin, cis-platinum 11 diamine dichloride procarbazine, vinblastine vincristine and the like. The present method and device are suitable for the continuous monitoring of the levels of these and other anticancer drugs in biological fluids such as blood, serum, urine and the like. The optrode of the instant invention also enables the measurement of the levels of these drugs from a remote location and from multiple samples.

Miller, Holly H. (Bethel Island, CA); Hirschfeld, deceased, Tomas B. (late of Livermore, CA)

1991-01-01T23:59:59.000Z

52

Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care  

E-Print Network [OSTI]

Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker.e., a cell phone/charge-coupled device (CCD) to quantify an ovarian cancer biomarker, HE4, in urine. Integration of a mobile application with a cell phone enabled immediate processing of microchip ELISA results

Demirci, Utkan

53

Method of detecting cancer in a single cell using mitochondrial correlation microscopy  

DOE Patents [OSTI]

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L

2013-06-25T23:59:59.000Z

54

Method for detecting cancer in a single cell using mitochondrial correlation microscopy  

DOE Patents [OSTI]

A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.

Gourley, Paul L. (Albuquerque, NM)

2012-03-06T23:59:59.000Z

55

Improving the detectability of gravitational wave counterparts of short hard gamma ray bursts .  

E-Print Network [OSTI]

??With multiple observatories and missions being planned for detecting orphaned afterglows associated with gamma-ray bursts (GRBs) we emphasize the importance of developing data analysis strategies (more)

[No author

2013-01-01T23:59:59.000Z

56

Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including early detection of cancers  

DOE Patents [OSTI]

An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of CEA is described including injecting a possible CEA-containing sample into a sensor cell including the assay element, maintaining the sample within the sensor cell for time sufficient for binding to occur between CEA present within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.

Martinez, Jennifer S. (Santa Fe, NM); Swanson, Basil I. (Los Alamos, NM); Shively, John E. (Arcadia, CA); Li, Lin (Monrovia, CA)

2009-06-02T23:59:59.000Z

57

Improving Cyber-Security of Smart Grid Systems via Anomaly Detection and Linguistic Domain Knowledge  

SciTech Connect (OSTI)

The planned large scale deployment of smart grid network devices will generate a large amount of information exchanged over various types of communication networks. The implementation of these critical systems will require appropriate cyber-security measures. A network anomaly detection solution is considered in this work. In common network architectures multiple communications streams are simultaneously present, making it difficult to build an anomaly detection solution for the entire system. In addition, common anomaly detection algorithms require specification of a sensitivity threshold, which inevitably leads to a tradeoff between false positives and false negatives rates. In order to alleviate these issues, this paper proposes a novel anomaly detection architecture. The designed system applies the previously developed network security cyber-sensor method to individual selected communication streams allowing for learning accurate normal network behavior models. Furthermore, the developed system dynamically adjusts the sensitivity threshold of each anomaly detection algorithm based on domain knowledge about the specific network system. It is proposed to model this domain knowledge using Interval Type-2 Fuzzy Logic rules, which linguistically describe the relationship between various features of the network communication and the possibility of a cyber attack. The proposed method was tested on experimental smart grid system demonstrating enhanced cyber-security.

Ondrej Linda; Todd Vollmer; Milos Manic

2012-08-01T23:59:59.000Z

58

Bonus-- Cameras Designed to Strengthen Nuclear Security Can Also Detect Cancer  

Broader source: Energy.gov [DOE]

Technologies that are improving our ability to prevent the spread of nuclear weapons and material are also saving lives on a daily basis.

59

FOCUS www.rsc.org/loc | Lab on a Chip Improving fluorescence detection in lab on  

E-Print Network [OSTI]

) graft on glass. Two cell populations are separately labeled with live cell dyes and are mixed and seeded and sensitivity, due primarily to sub-optimal light collection. More sensi- tive, higher resolution LOC devices for performing high-sensitivity and high-resolution fluo- rescence detection within LOC devices. Fluorescence

Fygenson, Deborah Kuchnir

60

Non-invasive detection of oral cancer using reflectance and fluorescence spectroscopy  

E-Print Network [OSTI]

In vivo reflectance and fluorescence spectra were collected from patients with oral lesions, as well as healthy volunteers, in order to evaluate the potential of spectroscopy to serve as a non-invasive tool for the detection ...

McGee, Sasha Alanda

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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61

Improved backscatter x-ray detection for anti-terrorist applications  

SciTech Connect (OSTI)

Currently the most common method to determine the contents of a package suspected of containing an explosive device is to use transmission radiography. This technique requires that an x-ray source and film be placed on opposite sides of the package. This poses a problem if the package is placed so that only one side is accessible, such as against a wall. There is also a threat to personnel and property since explosive devices may be booby trapped. The authors have developed a method to x-ray a package using backscattered x-rays based on similar work for landmine detection. This procedure eliminates the use of film behind the target. All of the detection is done from the same side as the source. Backscatter experiments at Sandia National Laboratories have been conducted on mock bombs in packages. They are able to readily identify the bomb components. The images that are obtained in this procedure are done in real time and the image is displayed on a computer screen. Preliminary experiments have also imaged objects within or behind a wall. They are currently using a scanning x-ray source and scintillating plastic detectors. It can take several hours to image a briefcase size object. This time could be reduced if better x-ray detection methods could be used. They have looked at using pinhole photography and CCD cameras to reduce this time.

Shope, S.L.; Lockwood, G.J.; Selph, M.M.; Wehlburg, J.C.

1999-12-01T23:59:59.000Z

62

Method for improved selectivity in photo-activation and detection of molecular diagnostic agents  

DOE Patents [OSTI]

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.

Wachter, E.A.; Fisher, W.G.; Dees, H.C.

1998-11-10T23:59:59.000Z

63

Modifications of alpha processing software to improve calculation of limits for qualitative detection  

SciTech Connect (OSTI)

The work described in this report was done for the Bioassay Counting Laboratory (BCL) of the Center of Excellence for Bioassay of the Analytical Services Organization at the Oak Ridge Y-12 Plant. BCL takes urine and fecal samples and tests for alpha radiation. An automated system, supplied by Canberra Industries, counts the activities in the samples and processes the results. The Canberra system includes hardware and software. The managers of BCL want to improve the accuracy of the results they report to their final customers. The desired improvements are of particular interest to the managers of BCL because the levels of alpha-emitting radionuclides in samples measured at BCL are usually so low that a significant fraction of the measured signal is due to background and to the reagent material used to extract the radioactive nuclides from the samples. Also, the background and reagent signals show a significant level of random variation. The customers at BCL requested four major modifications of the software. The requested software changes have been made and tested. The present report is in two parts. The first part describes what the modifications were supposed to accomplish. The second part describes the changes on a line-by-line basis. The second part includes listings of the changed software and discusses possible steps to correct a particular error condition. Last, the second part describes the effect of truncation errors on the standard deviations calculated from samples whose signals are very nearly the same.

Kirkpatrick, J.R.

1997-01-01T23:59:59.000Z

64

Multimodal spectroscopy : real-time diagnosis of breast cancer during core needle biopsy  

E-Print Network [OSTI]

Early detection of breast cancer is critical for improved survival. Currently, breast abnormalities are diagnosed based on a histopathological evaluation of tissue removed during core needle biopsy. Microcalcifications are ...

Volynskaya, Zoya I

2010-01-01T23:59:59.000Z

65

Detect  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to UserProduct: CrudeOffice ofINLNuclear262AboutDesignerFile SystemDetect

66

Extending the Sensitivity to the Detection of WIMP Dark Matter with an Improved Understanding of the Limiting Neutron Backgrounds  

SciTech Connect (OSTI)

The Cryogenic Dark Matter Search (CDMS) uses position-sensitive Germanium and Silicon crystals in the direct detection of Weakly Interacting Massive Particles (WIMPs) believed to constitute most of the dark matter in the Universe. WIMP interactions with matter being rare, identifying and eliminating known backgrounds is critical for detection. Event-by-event discrimination by the detectors rejects the predominant gamma and beta backgrounds while Monte Carlo simulations help estimate, and subtract, the contribution from the neutrons. This thesis describes the effort to understand neutron backgrounds as seen in the two stages of the CDMS search for WIMPs. The first stage of the experiment was at a shallow site at the Stanford Underground Facility where the limiting background came from high-energy neutrons produced by cosmic-ray muon interactions in the rock surrounding the cavern. Simulations of this background helped inform the analysis of data from an experimental run at this site and served as input for the background reduction techniques necessary to set new exclusion limits on the WIMP-nucleon cross-section, excluding new parameter space for WIMPs of masses 8-20 GeV/c{sup 2}. This thesis considers the simulation methods used as well as how various event populations in the data served as checks on the simulations to allow them to be used in the interpretation of the WIMP-search data. The studies also confirmed the presence of a limiting neutron background at the shallow site, necessitating the move to the 713-meter deep Soudan Underground Facility. Similar computer-based studies helped quantify the neutron background seen at the deeper site and informed the analysis of the data emerging from the first physics run of the experiment at Soudan. In conjunction with the WIMP-search and calibration data, the simulations confirmed that increased depth considerably reduced the neutron backgrounds seen, greatly improving the sensitivity to WIMP detection. The data run set an upper limit of 4 x 10{sup -43} on the WIMP-nucleon cross section for a WIMP mass of 60 GeV/c{sup 2} . Upper limits to the rate of background neutrons have also been determined.

Kamat, Sharmila; /Case Western Reserve U.; ,

2005-01-01T23:59:59.000Z

67

Cloud Detection with MODIS, Part I: Improvements in the MODIS Cloud Mask for Collection 5 *Richard A. Frey, Steven A. Ackerman, Yinghui Liu, Kathleen I. Strabala, Hong Zhang,  

E-Print Network [OSTI]

Cloud Detection with MODIS, Part I: Improvements in the MODIS Cloud Mask for Collection 5 *Richard.frey@ssec.wisc.edu August 2007 #12;ABSTRACT Significant improvements have been made to the MODIS cloud mask (MOD35 and MYD35 to the 3.9-12 m and 11-12 m cloud tests. More non-MODIS ancillary input data has been added. Land and sea

Sheridan, Jennifer

68

Vision 20/20: The role of Raman spectroscopy in early stage cancer detection and feasibility for application in radiation therapy response assessment  

SciTech Connect (OSTI)

Raman spectroscopy is an optical technique capable of identifying chemical constituents of a sample by their unique set of molecular vibrations. Research on the applicability of Raman spectroscopy in the differentiation of cancerous versus normal tissues has been ongoing for many years, and has yielded successful results in the context of prostate, breast, brain, skin, and head and neck cancers as well as pediatric tumors. Recently, much effort has been invested on developing noninvasive Raman probes to provide real-time diagnosis of potentially cancerous tumors. In this regard, it is feasible that the Raman technique might one day be used to provide rapid, minimally invasive real-time diagnosis of tumors in patients. Raman spectroscopy is relatively new to the field of radiation therapy. Recent work involving cell lines has shown that the Raman technique is able to identify proteins and other markers affected by radiation therapy. Although this work is preliminary, one could ask whether or not the Raman technique might be used to identify molecular markers that predict radiation response. This paper provides a brief review of Raman spectroscopic investigations in cancer detection, benefits and limitations of this method, advances in instrument development, and also preliminary studies related to the application of this technology in radiation therapy response assessment.

Devpura, Suneetha, E-mail: sdevpur1@hfhs.org; Barton, Kenneth N.; Brown, Stephen L.; Siddiqui, Farzan; Chetty, Indrin J. [Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202 (United States)] [Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202 (United States); Palyvoda, Olena [College of Engineering, Wayne State University, Detroit, Michigan 48202 (United States)] [College of Engineering, Wayne State University, Detroit, Michigan 48202 (United States); Kalkanis, Steven [Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202 (United States)] [Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202 (United States); Naik, Vaman M. [Department of Natural Sciences, University of Michigan-Dearborn, Dearborn, Michigan 48128 (United States)] [Department of Natural Sciences, University of Michigan-Dearborn, Dearborn, Michigan 48128 (United States); Naik, Ratna [Department of Physics and Astronomy, Wayne State University, Detroit, Michigan 48201 (United States)] [Department of Physics and Astronomy, Wayne State University, Detroit, Michigan 48201 (United States)

2014-05-15T23:59:59.000Z

69

Validation of angle-resolved polarized light scattering spectroscopy as a diagnostic tool for pre-cancer detection  

E-Print Network [OSTI]

Light scattering spectroscopy has emerged as a valuable diagnostic tool for cancer diagnoses in the past ten years. The interaction of light with cellular structures brings out information about morphological changes ...

Kalashnikov, Maxim M

2009-01-01T23:59:59.000Z

70

Bi-plane correlation imaging for improved detection of lung nodules Ehsan Samei1,2,3  

E-Print Network [OSTI]

approach that utilizes angular information from a bi-plane digital acquisition in conjunction with computer. The correlated suspect lesions were registered as positive. Using an optimum ­3o vertical geometry and processing. INTRODUCTION Lung cancer is a leading cause of death in the US, surpassing the mortality associated with breast

71

Intensity-Modulated Radiotherapy is Associated With Improved Global Quality of Life Among Long-term Survivors of Head-and-Neck Cancer  

SciTech Connect (OSTI)

Purpose: To compare the long-term quality of life among patients treated with and without intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Methods and Materials: University of Washington Quality of Life instrument scores were reviewed for 155 patients previously treated with radiation therapy for locally advanced head-and-neck cancer. All patients were disease free and had at least 2 years of follow-up. Eighty-four patients (54%) were treated with IMRT. The remaining 71 patients (46%) were treated with three-dimensional conformal radiotherapy (3D CRT) by use of initial opposed lateral fields matched to a low anterior neck field. Results: The mean global quality of life scores were 67.5 and 80.1 for the IMRT patients at 1 and 2 years, respectively, compared with 55.4 and 57.0 for the 3D CRT patients, respectively (p < 0.001). At 1 year after the completion of radiation therapy, the proportion of patients who rated their global quality of life as 'very good' or 'outstanding' was 51% and 41% among patients treated by IMRT and 3DCRT, respectively (p = 0.11). At 2 years, the corresponding percentages increased to 73% and 49%, respectively (p < 0.001). On multivariate analysis accounting for sex, age, radiation intent (definitive vs. postoperative), radiation dose, T stage, primary site, use of concurrent chemotherapy, and neck dissection, the use of IMRT was the only variable independently associated with improved quality of life (p = 0.01). Conclusion: The early quality of life improvements associated with IMRT not only are maintained but apparently become more magnified over time. These data provide powerful evidence attesting to the long-term benefits of IMRT for head-and-neck cancer.

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Farwell, D. Gregory; Luu, Quang [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Otolaryngology-Head and Neck Surgery, University of California Davis Cancer Center, Sacramento, CA (United States); Vazquez, Esther G. [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Lau, Derick H. [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Medical Oncology, University of California Davis Cancer Center, Sacramento, CA (United States); Purdy, James A. [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)] [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, CA (United States)

2012-09-01T23:59:59.000Z

72

JOURNAL OF INFORMATION SCIENCE AND ENGINEERING 24, 159-174 (2008) Improving the Efficacy of a Termination Detection Algorithm*  

E-Print Network [OSTI]

of a Termination Detection Algorithm* SATHYA PERI AND NEERAJ MITTAL Department of Computer Science The University@utdallas.edu} An important problem in distributed systems is to detect termination of a distributed computation. A distributed computation is said to have terminated when all processes have become passive and all channels

Mittal, Neeraj

2008-01-01T23:59:59.000Z

73

Cancer Imaging Clinical Cancer Research  

E-Print Network [OSTI]

Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. Experimental Design: IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. Time- and concentration-dependent dye uptake and retention in normal and cancer cells and tissues were compared, and subcellular localization of the dyes and mechanisms of the dye uptake and retention in tumor cells were evaluated using organelle-specific tracking dyes and bromosulfophthalein, a competitive inhibitor of organic anion transporting peptides. These dyes were used to detect human cancer metastases in a mouse model and differentiate cancer cells from normal cells in blood. Results: These near-IR hepatamethine cyanine dyes were retained in cancer cells but not normal cells, in tumor xenografts, and in spontaneous tumors in transgenic mice. They can be used to detect cancer metastasis and cancer cells in blood with a high degree of sensitivity. The dyes were found to concentrate in the mitochondria and lysosomes of cancer cells, probably through organic anion transporting peptides,

Near Ir; Heptamethine Cyanine Dyemediated; Xiaojian Yang; Chunmeng Shi; Rong Tong; Weiping Qian; Haiyen E. Zhau; Ruoxiang Wang; Guodong Zhu; Jianjun Cheng; Vincent W. Yang; Tianmin Cheng; Maged Henary; Lucjan Strekowski; W. K. Chung

74

Retrospective Evaluation Reveals That Long-term Androgen Deprivation Therapy Improves Cause-Specific and Overall Survival in the Setting of Dose-Escalated Radiation for High-Risk Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To evaluate the role of androgen deprivation therapy (ADT) and duration for high-risk prostate cancer patients treated with dose-escalated radiation therapy (RT). Methods and Materials: A retrospective analysis of high-risk prostate cancer patients treated with dose-escalated RT (minimum 75 Gy) with or without ADT was performed. The relationship between ADT use and duration with biochemical failure (BF), metastatic failure (MF), prostate cancer-specific mortality (PCSM), non-prostate cancer death (NPCD), and overall survival (OS) was assessed as a function of pretreatment characteristics, comorbid medical illness, and treatment using Fine and Gray's cumulative incidence methodology. Results: The median follow-up time was 64 months. In men with National Comprehensive Cancer Network defined high-risk prostate cancer treated with dose-escalated RT, on univariate analysis, both metastasis (P<.0001; hazard ratio 0.34; 95% confidence interval 0.18-0.67; cumulative incidence at 60 months 13% vs 35%) and PCSM (P=.015; hazard ratio 0.41; 95% confidence interval 0.2-1.0; cumulative incidence at 60 months 6% vs 11%) were improved with the use of ADT. On multivariate analysis for all high-risk patients, Gleason score was the strongest negative prognostic factor, and long-term ADT (LTAD) improved MF (P=.002), PCSM (P=.034), and OS (P=.001). In men with prostate cancer and Gleason scores 8 to 10, on multivariate analysis after adjustment for other risk features, there was a duration-dependent improvement in BF, metastasis, PCSM, and OS, all favoring LTAD in comparison with STAD or RT alone. Conclusion: For men with high-risk prostate cancer treated with dose-escalated EBRT, this retrospective study suggests that the combination of LTAD and RT provided a significant improvement in clinical outcome, which was especially true for those with Gleason scores of 8 to 10.

Feng, Felix Y., E-mail: ffeng@med.umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Department of Radiation Oncology, Veterans Affairs Medical Center, Ann Arbor, Michigan (United States); Blas, Kevin; Olson, Karin; Stenmark, Matthew [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Sandler, Howard [Cedars Sinai Medical Center, Los Angeles, California (United States)] [Cedars Sinai Medical Center, Los Angeles, California (United States); Hamstra, Daniel A. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)

2013-05-01T23:59:59.000Z

75

The Effect of Early Detection of Occult Brain Metastases in HER2-Positive Breast Cancer Patients on Survival and Cause of Death  

SciTech Connect (OSTI)

Purpose: The aim of the study is to evaluate disease-free survival, survival from the detection of brain metastases, overall survival, and cause of death in patients with occult brain metastases (Group I) vs. patients with symptomatic brain metastases (Group II). Methods and Materials: In 80 HER2-positive breast cancer patients, treated with trastuzumab and cytostatic agents for metastatic disease, magnetic resonance imaging screening of the brain was performed, and in 29 patients (36%) occult brain metastasis was detected (Group I). Whole-brain radiotherapy was delivered to Group I. This first group was compared with 52 patients who had symptomatic brain metastases (Group II) and was treated the same way, at the same clinic, during the same time period. Results: Median disease-free survival was 17 months in Group I and 19.9 months in Group II (p = 0.58). The median time interval between the dissemination of the disease and the detection of occult or symptomatic brain metastases was 9 and 15 months, respectively (p = 0.11). When the brain metastases were detected, the median survival was 9 and 8.78 months, respectively (p = 0.80). The median overall survival was 53 and 51 months, respectively (p = 0.94). In the group with occult brain metastases (Group I) 16% of patients died because of progression within the brain. In the group with symptomatic brain metastases (Group II) the rate of cerebral death was 48% (p = 0.009). Conclusions: Whole-brain radiotherapy of occult brain metastases in HER2-positive breast cancer patients with visceral dissemination produces a three-fold decrease in cerebral deaths but does not prolong survival.

Niwinska, Anna, E-mail: alphaonetau@poczta.onet.p [Department of Breast Cancer and Reconstructive Surgery, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland); Tacikowska, Malgorzata [Department of Radiology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland); Murawska, Magdalena [Department of Biostatistics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw (Poland)

2010-07-15T23:59:59.000Z

76

A study of time-based features and regularity of manipulation to improve the detection of eating activity  

E-Print Network [OSTI]

;Abstract This thesis considers the problem of detecting when people eat by tracking their wrist motion have been instrumental in my decision of pursuing my Master's degree. iii #12;Table of Contents Title

Hoover, Adam

77

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer  

E-Print Network [OSTI]

--22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

Paxton, Anthony T.

78

Improved Survival in Patients With Stage III-IV Head and Neck Cancer Treated With Radiotherapy as Primary Local Treatment Modality  

SciTech Connect (OSTI)

Purpose: To evaluate the overall and cause-specific survival in patients with Stage III-IVb head and neck squamous cell carcinoma treated with radiotherapy (RT) as the primary local treatment modality. Methods and Materials: The survival of patients with American Joint Committee on Cancer Stage III-IVb head and neck squamous cell carcinoma treated with primary RT was queried using the Surveillance, Epidemiology and End Results database. The effect of the year of treatment on overall and cause-specific survival was analyzed as a categorical and continuous variable. The patterns of care for these patients were also evaluated. Results: Between 1988 and 2004, 6,759 patients were identified. Survival was significantly improved in patients treated more recently. When analyzed as a continuous variable, each year was associated with a 3% and 4.1% reduction in the relative risk of overall and cause-specific mortality, respectively (p < 0.0001). Patients treated after 1998 had a 7.6% and 6.1% absolute improvement in overall and cause-specific survival, respectively, compared with patients treated before 1998 (overall survival, hazard ratio, 0.81; cause-specific survival, hazard ratio, 0.77; p < 0.0001). This benefit in survival was limited to tumors of the oral cavity, oropharynx, and hypopharynx. The use of RT increased among patients treated more recently. This shift in patterns of care was most pronounced for tumors of the larynx and hypopharynx. Conclusions: The overall and cause-specific survival of patients with Stage III-IVb head and neck squamous cell carcinoma treated with primary RT has improved with time. The improvement is consistent with that observed in a large meta-analysis of randomized patients treated with concurrent chemoradiotherapy.

Rusthoven, Kyle E.; Raben, David [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Chen Changhu [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States)], E-mail: Changhu.Chen@UCHSC.edu

2008-10-01T23:59:59.000Z

79

Received 14 Aug 2013 | Accepted 8 Sep 2014 | Published 13 Oct 2014 Improving battery safety by early detection of  

E-Print Network [OSTI]

Stanford Institute for Materials and Energy Sciences, SLAC National Accelerator Laboratory, 2575 Sand Hill and show great promise for emerging applications in transportation and wind­solar-grid energy storage report a new strategy for improving safety by designing a smart battery that allows internal battery

Cui, Yi

80

Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer  

SciTech Connect (OSTI)

Ultrasound imaging, having the advantages of low-cost and non-invasiveness over MRI and X-ray CT, was reported by several studies as an adequate complement to fluorescence molecular tomography with the perspective of improving localization and quantification of fluorescent molecular targets in vivo. Based on the previous work, an improved dual-modality Fluorescence-Ultrasound imaging system was developed and then validated in imaging study with preclinical tumor model. Ultrasound imaging and a profilometer were used to obtain the anatomical prior information and 3D surface, separately, to precisely extract the tissue boundary on both sides of sample in order to achieve improved fluorescence reconstruction. Furthermore, a pattern-based fluorescence reconstruction on the detection side was incorporated to enable dimensional reduction of the dataset while keeping the useful information for reconstruction. Due to its putative role in the current imaging geometry and the chosen reconstruction technique, we developed an attenuation compensated Born-normalization method to reduce the attenuation effects and cancel off experimental factors when collecting quantitative fluorescence datasets over large area. Results of both simulation and phantom study demonstrated that fluorescent targets could be recovered accurately and quantitatively using this reconstruction mechanism. Finally, in vivo experiment confirms that the imaging system associated with the proposed image reconstruction approach was able to extract both functional and anatomical information, thereby improving quantification and localization of molecular targets.

Li, Baoqiang; Berti, Romain; Abran, Maxime; Lesage, Frdric, E-mail: frederic.lesage@polymtl.ca [Institute of Biomedical Engineering, cole Polytechnique de Montral, Montreal, Quebec H3C 3A7 (Canada) [Institute of Biomedical Engineering, cole Polytechnique de Montral, Montreal, Quebec H3C 3A7 (Canada); Montreal Heart Institute, Montreal, Quebec H1T 1C8 (Canada)

2014-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Early lung cancer detection project: Evaluation of 5, 10, 15, 20 tetrakis (4-carboxyphenyl) porphine (H{sub 2}TCPP). Final report  

SciTech Connect (OSTI)

The author evaluated a synthetic porphyrin, 5, 10, 15, 20 tetrakis (4-carboxyphenyl) porphene (H{sub 2}TCPP) as a marker of carcinogenesis. H{sub 2}TCPP was compared with two other carcinogenesis markers evaluated in the laboratory for their ability to detect exfoliated sputum cells undergoing transformation to lung cancer. In the present project the authors first established optimal conditions for cultured neoplastic and non-neoplastic (sputum) cells to take up H{sub 2}TCPP. This was accomplished using spectrofluorimetry and video-enhanced fluorescent microscopy to maximize H{sub 2}TCPP auto-fluorescence across a matrix of substrate conditions, including; reagent concentration, incubation time, temperature, and pH. The second aim was to validate H{sub 2}TCPP on clinical material obtained from subjects monitored in advance of clinical cancer and link those marker results with subsequent histologic confirmation of disease. This was accomplished by applying H{sub 2}TCPP to sputum specimens archived by the Frost Center at Johns Hopkins which maintains a record of the clinical course and long-term follow-up for the patients from whom the specimens were obtained. The authors have used fluorescent immunostaining and flow cytometry to compare uptake of these cytoplasmic Mabs to that of a potential new marker of carcinogenesis, 5, 10, 15, 20 tetrakis (4 carboxyphenyl) porphene (H{sub 2}TCPP). The nuclear uptake of H{sub 2}TCPP was compared to a standard quantitative fluorescent DNA marker (7-AAD).

Tockman, M.S.

1998-10-01T23:59:59.000Z

82

Forward Intensity-Modulated Radiotherapy Planning in Breast Cancer to Improve Dose Homogeneity: Feasibility of Class Solutions  

SciTech Connect (OSTI)

Purpose: To explore forward planning methods for breast cancer treatment to obtain homogeneous dose distributions (using International Commission on Radiation Units and Measurements criteria) within normal tissue constraints and to determine the feasibility of class solutions. Methods and Materials: Treatment plans were optimized in a stepwise procedure for 60 patients referred for postlumpectomy irradiation using strict dose constraints: planning target volume (PTV){sub 95%} of >99%; V{sub 107%} of <1.8 cc; heart V{sub 5Gy} of <10% and V{sub 10Gy} of <5%; and mean lung dose of <7 Gy. Treatment planning started with classic tangential beams. Optimization was done by adding a maximum of four segments before adding beams, in a second step. A breath-hold technique was used for heart sparing if necessary. Results: Dose constraints were met for all 60 patients. The classic tangential beam setup was not sufficient for any of the patients; in one-third of patients, additional segments were required (<3), and in two-thirds of patients, additional beams (<2) were required. Logistic regression analyses revealed central breast diameter (CD) and central lung distance as independent predictors for transition from additional segments to additional beams, with a CD cut-off point at 23.6 cm. Conclusions: Treatment plans fulfilling strict dose homogeneity criteria and normal tissue constraints could be obtained for all patients by stepwise dose intensity modification using limited numbers of segments and additional beams. In patients with a CD of >23.6 cm, additional beams were always required.

Peulen, Heike, E-mail: h.peulen@nki.nl [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands); Hanbeukers, Bianca; Boersma, Liesbeth; Baardwijk, Angela van; Ende, Piet van den; Houben, Ruud; Jager, Jos; Murrer, Lars; Borger, Jacques [Department of Radiation Oncology, MAASTRO Clinic, Maastricht (Netherlands)

2012-01-01T23:59:59.000Z

83

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung  

DOE Patents [OSTI]

A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.

Cole, D.A.; Moody, D.C. III; Ellinwood, L.E.; Klein, M.G.

1992-11-10T23:59:59.000Z

84

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung  

DOE Patents [OSTI]

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques cna be used to locate the malignant tissue mass.

Cole, Dean A. (60 San Juan St., Los Alamos, NM 87544); Moody, III, David C. (402 Pine Tree La., Boulder, CO 80304); Ellinwood, L. Edward (694 Sperber La., Grand Junction, CO 81506); Klein, M. Gerard (715 Victor Dr., Grand Junction, CO 81506)

1992-01-01T23:59:59.000Z

85

Method to improve reliability of a fuel cell system using low performance cell detection at low power operation  

DOE Patents [OSTI]

A system and method for detecting a low performing cell in a fuel cell stack using measured cell voltages. The method includes determining that the fuel cell stack is running, the stack coolant temperature is above a certain temperature and the stack current density is within a relatively low power range. The method further includes calculating the average cell voltage, and determining whether the difference between the average cell voltage and the minimum cell voltage is greater than a predetermined threshold. If the difference between the average cell voltage and the minimum cell voltage is greater than the predetermined threshold and the minimum cell voltage is less than another predetermined threshold, then the method increments a low performing cell timer. A ratio of the low performing cell timer and a system run timer is calculated to identify a low performing cell.

Choi, Tayoung; Ganapathy, Sriram; Jung, Jaehak; Savage, David R.; Lakshmanan, Balasubramanian; Vecasey, Pamela M.

2013-04-16T23:59:59.000Z

86

Improved detection of rough defects for ultrasonic NDE inspections based on finite element modeling of elastic wave scattering  

SciTech Connect (OSTI)

Defects which posses rough surfaces greatly affect ultrasonic wave scattering behaviour, often reducing the magnitude of reflected signals. Ultrasonic inspections rely upon this response for detecting and sizing flaws. For safety critical components reliable characterisation is crucial. Therefore, providing an accurate means to predict reductions in signal amplitude is essential. An extension of Kirchhoff theory has formed the basis for the UK power industry inspection justifications. However, it is widely recognised that these predictions are pessimistic owing to analytical approximations. A numerical full field modelling approach does not fall victim to such limitations. Here, a Finite Element model is used to aid in setting a non-conservative reporting threshold during the inspection of a large pressure vessel forging that might contain embedded rough defects. The ultrasonic response from multiple rough surfaces defined by the same statistical class is calculated for normal incident compression waves. The approach is validated by comparing coherent scattering with predictions made by Kirchhoff theory. At lower levels of roughness excellent agreement is observed, whilst higher values confirm the pessimism of Kirchhoff theory. Furthermore, the mean amplitude in the specular direction is calculated. This represents the information obtained during an inspection, indicating that reductions due to increasing roughness are significantly less than the coherent component currently being used.

Pettit, J. R. [Rolls-Royce Nuclear, PO BOX 2000, Derby, UK, DE21 7XX and Research Centre for NDE, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom); Walker, A. [Rolls-Royce Nuclear, PO BOX 2000, Derby DE21 7XX (United Kingdom); Lowe, M. J. S. [Research Centre for NDE, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom)

2014-02-18T23:59:59.000Z

87

From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory  

SciTech Connect (OSTI)

In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

Martineau, Rebecca M [Los Alamos National Laboratory

2012-07-26T23:59:59.000Z

88

A filter-based feature selection approach for identifying potential biomarkers for lung cancer  

E-Print Network [OSTI]

Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

2011-03-21T23:59:59.000Z

89

Also in This Issue 2 International Cancer  

E-Print Network [OSTI]

Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

Müller, Jens-Dominik

90

aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c  

E-Print Network [OSTI]

--22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

Paxton, Anthony T.

91

1284 IEEE TRANSACTIONS ON POWER DELIVERY, VOL. 26, NO. 2, APRIL 2011 Improving SVM-Based Nontechnical Loss Detection in Power Utility Using  

E-Print Network [OSTI]

classification. I. INTRODUCTION DISTRIBUTON losses in power utilities originating from electricity theft-Based Nontechnical Loss Detection in Power Utility Using the Fuzzy Inference System Jawad Nagi, Keem Siah Yap, Sieh of fraud and electricity theft in power distribution utilities. Pre- vious work was carried out by using

Ducatelle, Frederick

92

Cancer Cells DOI: 10.1002/anie.201100115  

E-Print Network [OSTI]

Cancer Cells DOI: 10.1002/anie.201100115 Micromachine-Enabled Capture and Isolation of Cancer Cells (CTCs) are the primary entities responsible for spawning cancer metastasis. Detection of CTCs provides an indicator for the clinical diagnosis and prognosis of various types of cancers. Several approaches, based

Zhang, Liangfang

93

Improving Soft-Tissue Contrast in Four-Dimensional Computed Tomography Images of Liver Cancer Patients Using a Deformable Image Registration Method  

SciTech Connect (OSTI)

Purpose: To investigate a deformable image registration method to improve soft-tissue contrast in four-dimensional (4D) computed tomography (CT) images of the liver. Methods and Materials: Ten patients with hepatocellular carcinoma underwent 4D CT scan for radiotherapy treatment planning on a positron emission tomography/CT scanner. Four-dimensional CT images were binned into 10 equispaced phases. The exhale phase served as the reference phase, and images from the other nine phases were coregistered to the reference phase image using an intensity-based, automatic deformable image registration method. Then the coregistered images were combined to create a single, high-quality reconstructed CT image at exhale phase as the new reference for target delineation. The extent of image quality enhancement was quantified relative to the original CT by calculating the signal-to-noise ratio and the contrast-to-noise ratio. Results: The soft tissue image contrast was noticeably better after deformable image registration than in the original scans. Signal-to-noise ratios inside the liver region of interest increased for all patients by a factor of 3.0 (range, 2.3-3.7). The improvement in image quality was not linearly proportionate to the number of images averaged. Using only 6 phases can achieve at least 85% of the contrast enhancement that can be achieved using all 10 phases. We also found that contrast enhancement was inversely proportional to the original image quality (p = 0.006), and the contrast enhancement is attained with little loss of spatial resolution. Conclusions: This deformable image registration method is feasible to improve soft-tissue image quality in 4D CT images.

Wang He [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Krishnan, Sunil [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Wang Xiaochun; Beddar, A. Sam; Briere, Tina M. [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Crane, Christopher H. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Dong Lei [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: ldong@mdanderson.org

2008-09-01T23:59:59.000Z

94

Advancing Explosives Detection Capabilities: Vapor Detection  

ScienceCinema (OSTI)

A new, PNNL-developed method provides direct, real-time detection of trace amounts of explosives such as RDX, PETN and C-4. The method selectively ionizes a sample before passing the sample through a mass spectrometer to detect explosive vapors. The method could be used at airports to improve aviation security.

Atkinson, David

2014-07-24T23:59:59.000Z

95

Computer enhancement of mammograms for assistance in detection of microcalcifications  

E-Print Network [OSTI]

At current rate of incidence, breast cancer will afflict about 9% of women. Regular mammograms have proven to be effective in early detection of breast cancer. In mammograms the presence of microcalcification clusters is an indicator of breast...

Estevez, Leonardo William

1995-01-01T23:59:59.000Z

96

The National Cancer Survivorship Initiative: new and emerging evidence on the ongoing needs of cancer survivors  

E-Print Network [OSTI]

; #12; A key commitment of the Cancer Reform Strategy (Department of Health, 2007) in UK, and endorsed Floor Portland House, Bressenden Place, London SW1E 5RS, UK; 2 Faculty of Health Sciences, University in Improving Outcomes Strategy for Cancer (Department of Health, 2011), was to establish a National Cancer

Quartly, Graham

97

Alpha and recoil track detection in poly(methyl methacrylate) (PMMA)Towards a method for in vitro assessment of radiopharmaceuticals internalized in cancer cells  

SciTech Connect (OSTI)

A method for detection and characterization of single MeV ?-particle and recoil tracks in PMMA photoresist by atomic force microscopy (AFM) analysis has been demonstrated. The energy deposition along the track is shown to lead to a latent pattern in the resist due to contrast reversal. It has been shown that the pattern, consisting of conical spikes, can be developed by conventional processing as a result of the dissolution rate of poly(methyl methacrylate) (PMMA) being greater than that for the modified material in the cylindrical volume of the track core. The spikes can be imaged and counted by routine AFM analysis. Investigations by angular-resolved near-grazing incidence reveal additional tracks that correspond to recoil tracks. The observations have been correlated with modelling, and shown to be in qualitative agreement with prevailing descriptions of collision cascades. The results may be relevant to technologies that are based on detection and characterization of single energetic ions. In particular, the direct visualization of the collision cascade may allow more accurate estimates of the actual interaction volume, which in turn will permit more precise assessment of dose distribution of ?-emitting radionuclides used for targeted radiotherapy. The results could also be relevant to other diagnostic or process technologies based on interaction of energetic ions with matter.

Myhra, S., E-mail: sverre.myhra@materials.ox.ac.uk; Chakalova, R. [Oxford University Begbroke Science Park, University of Oxford, Oxford (United Kingdom)] [Oxford University Begbroke Science Park, University of Oxford, Oxford (United Kingdom); Falzone, N. [MRC/CRUK Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, United Kingdom and Department of Biomedical Science, Tshwane University of Technology, Pretoria (South Africa)] [MRC/CRUK Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, United Kingdom and Department of Biomedical Science, Tshwane University of Technology, Pretoria (South Africa)

2014-03-15T23:59:59.000Z

98

STOMACH CANCER 9. STOMACH CANCER  

E-Print Network [OSTI]

of association and strength of evidence Increases risk Decreases risk Convincing or probable Helicobacter pylori/obesity 9 1 Helicobacter and Cancer Collaborative Group, 2001; 2 International Agency for Research on Cancer

Paxton, Anthony T.

99

Three-Dimensional Thermal Tomography Advances Cancer Treatment...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

100

acid biomarker detection: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Websites Summary: .g., cancer, Alzheimer's disease) by positron emission tomography (PET).3 In a similar vein, we have developedDisease Detection by Ultrasensitive...

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Detection Science  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry for Measurement and Detection Science Chemistry for Measurement and Detection Science Project Description Chemistry used in measurement and detection science plays a...

102

Predictive and therapeutic markers in ovarian cancer  

DOE Patents [OSTI]

Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

2013-03-26T23:59:59.000Z

103

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM  

E-Print Network [OSTI]

CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

Illinois at Chicago, University of

104

[CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief  

E-Print Network [OSTI]

[CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

Jin, Jiashun

105

Improving Tamper Detection for Hazardous Waste Security  

SciTech Connect (OSTI)

Since September 11, waste managers are increasingly expected to provide effective security for their hazardous wastes. Tamper-indicating seals can help. This paper discusses seals, and offers recommendations for how to choose and use them.

Johnston, R. G.; Garcia, A. R. E.; Pacheco, N.; Martinez, R. K.; Martinez, D. D.; Trujillo, S. J.; Lopez, L. N.

2003-02-26T23:59:59.000Z

106

DICTIONARY EXTENSION FOR IMPROVING AUTOMATED SENTIMENT DETECTION  

E-Print Network [OSTI]

algorithms such as Pointwise Mutual Information - Information Retrieval (PMI-IR) and Latent Semantic Analysis Information - Infor- mation Retrieval (PMI-IR). Our evaluation shows that this approach leads to gains how we used LSA and PMI-IR to find similar values and how the prop- agation of the sentiment values

Hammerton, James

107

Quantitative spectroscopy for detection of cervical dysplasia  

E-Print Network [OSTI]

The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection ...

Mirkovi?, Jelena, Ph. D. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

108

Early Detection Saves Lives | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Low-dose image scanner In 2000, the WHPP added low-dose CT scanning for early lung cancer detection to the medical screening on a pilot basis at a limited number of DOE sites,...

109

Real-world Polymorphic Attack Detection Michalis Polychronakis,1  

E-Print Network [OSTI]

proposed network-level emulation, a heuristic detection method that scans network traffic to detect, sophisticated obfuscation schemes. Keywords Polymorphism, intrusion detection, code emulation 1. Introduction them under control for as long as possible. As detection mechanisms improve, attackers employ

Markatos, Evangelos P.

110

Application Of LIF Technique In The Diagnosis Of Some Human Cancer Types  

SciTech Connect (OSTI)

Fluorescence spectroscopy is an evolving technology that can rapidly differentiate between benign and malignant tissues. These differences are thought to be due to endogenous fluorophores, including nicotinamide adenine dinucleotide, flavin adenine dinucleotide, and tryptophan, and absorbers such as {beta}-carotene and hemoglobin. This is a non-invasive diagnostic tool that can identify diseased tissue sites in situ and in real time could have a major impact on the detection and treatment of cancer. This study evaluates the utility of autofluorescence and spectroscopy to distinguish tissue transformation associated with the malignant change in two types of human cancer - colorectal and breast cancer - Fluorescence spectra were obtained using a high-sensitivity fiber optic spectrometer and using two types of excitation sources, Argon laser with an emission at wavelength 488 nm and Xenon lamp. The results showed that the fluorescence intensity changes from normal to malignant tissue samples may be explained in terms of simple collagen, oxidized riboflavins and NAD(P)H intensity changes. In the future, improving our understanding of the biological changes that can be assessed using spectroscopy will not only improve optical techniques but also provide new tools to better understand cancer biology.

El-Hussein, A.; Kasem, A. K.; Harith, M. A. [National Institute of Laser Enhanced Science, Cairo University (Egypt); Ismail, H. [National Cancer Institute, Cairo University (Egypt)

2009-09-27T23:59:59.000Z

111

Friend to Friend Cancer Early Detection  

E-Print Network [OSTI]

, Brooks, Burnet, Cameron, Carson, Cass, Castro, Cherokee, Childress, Clay, Colorado, Cooke, Cochran

112

Cancer, Palliative and End of Life Care ResearchProjects2012  

E-Print Network [OSTI]

Cancer, Palliative and End of Life Care ResearchProjects2012 #12;2 5 4 Cancer, Palliative and End and students working together to transform care and improve outcomes for individuals affected by cancer, other the right questions to generate theory, influence policy and change practice. Cancer survivorship

Anderson, Jim

113

Reduce Building Energy Consumption by Improving the Supply Air Temperature Schedule and Recommissioning the Terminal Boxes, Submitted to the Energy Management and Operations Division at the M.D. Anderson Cancer Center  

E-Print Network [OSTI]

At the request of the Energy Management and Operations Department at M.D. Anderson Cancer Center, the Energy Systems Laboratory of Texas A&M University performed a study of optimizing the HVAC operation at its Basic Research Building. The Basic...

Liu, M.; Athar, A.; Zhu, Y.; Claridge, D. E.

1995-01-01T23:59:59.000Z

114

Josephine Ford Cancer Center Cancer Research Programs  

E-Print Network [OSTI]

Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

Berdichevsky, Victor

115

Compositions and methods for cancer treatment using targeted carbon nanotubes  

DOE Patents [OSTI]

The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

Harrison, Jr., Roger G; Resasco, Daniel E; Neves, Luis Filipe Ferreira

2013-08-27T23:59:59.000Z

116

1 888 939 3333 | cancer.ca Cancer Statistics  

E-Print Network [OSTI]

1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

Habib, Ayman

117

Relating to ion detection  

DOE Patents [OSTI]

The apparatus and method provide a technique for improving detection of alpha and/or beta emitting sources on items or in locations using indirect means. The emission forms generate ions in a medium surrounding the item or location and the medium is then moved to a detecting location where the ions are discharged to give a measure of the emission levels. To increase the level of ions generated and render the system particularly applicable for narrow pipes and other forms of conduits, the medium pressure is increased above atmospheric pressure. STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Orr, Christopher Henry (Calderbridge, GB); Luff, Craig Janson (Calderbridge, GB); Dockray, Thomas (Calderbridge, GB); Macarthur, Duncan Whittemore (Los Alamos, NM)

2001-01-01T23:59:59.000Z

118

Corps Improvement  

E-Print Network [OSTI]

to mitigate environmental impacts of the proj- ect. The Corps? Fort Worth District and the City of Dallas are using an innovative approach to return floodplain value to the Trinity River, while improving flood damage reduction. Big Fossil Creek Watershed... The Big Fossil Watershed Study will address flood damage reduction, while identifying associated water quality, ecosystem restoration and recreational opportunities within the basin. The watershed is located in northern Tarrant County, encompasses 73...

Wythe, Kathy

2007-01-01T23:59:59.000Z

119

Antibody-independent Targeted Quantification of TMPRSS2-ERG Fusion Protein Products in Prostate Cancer  

SciTech Connect (OSTI)

Fusions between the transmembrane protease serine 2 (TMPRSS2) and ETS related gene (ERG) represent one of the most specific biomarkers that define a distinct molecular subtype of prostate cancer. The studies on TMPRSS2-ERG gene fusions have seldom been performed at the protein level, primarily due to the lack of high-quality antibodies or an antibody-independent method that is sufficiently sensitive for detecting the truncated ERG protein products resulting from TMPRSS2-ERG gene fusions and alternative splicing. Herein, we applied a recently developed PRISM (high-pressure high-resolution separations with intelligent selection and multiplexing)-SRM (selected reaction monitoring) strategy for quantifying ERG protein in prostate cancer cell lines and tumors. The highly sensitive PRISM-SRM assays led to confident detection of 6 unique ERG peptides in either the TMPRSS2-ERG positive cell lines or tissues but not in the negative controls, indicating that ERG protein expression is highly correlated with TMPRSS2-ERG gene rearrangements. Significantly, our results demonstrated for the first time that at least two groups of ERG protein isoforms were simultaneously expressed at variable levels in TMPRSS2-ERG positive samples as evidenced by concomitant detection of two mutually exclusive peptides. Three peptides shared across almost all fusion protein products were determined to be the most abundant peptides, and hence can be used as signature peptides for detecting ERG overexpression resulting from TMPRSS2-ERG gene fusion. These PRISM-SRM assays provide valuable tools for studying TMPRSS2-ERG gene fusion protein products, thus improving our understanding of the role of TMPRSS2-ERG gene fusion in the biology of prostate cancer.

He, Jintang; Sun, Xuefei; Shi, Tujin; Schepmoes, Athena A.; Fillmore, Thomas L.; Petyuk, Vladislav A.; Xie, Fang; Zhao, Rui; Gritsenko, Marina A.; Yang, Feng; Kitabayashi, Naoki; Chae, Sung Suk; Rubin, Mark; Siddiqui, Javed; Wei, John; Chinnaiyan, Arul M.; Qian, Weijun; Smith, Richard D.; Kagan, Jacob; Srivastava, Sudhir; Rodland, Karin D.; Liu, Tao; Camp, David G.

2014-10-01T23:59:59.000Z

120

The National Cancer Institute,  

E-Print Network [OSTI]

The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

CANCER BIOLOGY Infectioustumourcells  

E-Print Network [OSTI]

CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

Nowak, Martin A.

122

Improved aethalometer  

DOE Patents [OSTI]

An improved aethalometer having a single light source and a single light detector and two light paths from the light source to the light detector. A quartz fiber filter is inserted in the device, the filter having a collection area in one light path and a reference area in the other light path. A gas flow path through the aethalometer housing allows ambient air to flow through the collection area of the filter so that aerosol particles can be collected on the filter. A rotating disk with an opening therethrough allows light for the light source to pass alternately through the two light paths. The voltage output of the detector is applied to a VCO and the VCO pulses for light transmission separately through the two light paths, are counted and compared to determine the absorption coefficient of the collected aerosol particles. 5 figs.

Hansen, A.D.

1988-01-25T23:59:59.000Z

123

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER  

E-Print Network [OSTI]

CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

Sherman, S. Murray

124

Acoustic enhancement for photo detecting devices  

DOE Patents [OSTI]

Provided are improvements to photo detecting devices and methods for enhancing the sensitivity of photo detecting devices. A photo detecting device generates an electronic signal in response to a received light pulse. An electro-mechanical acoustic resonator, electrically coupled to the photo detecting device, damps the electronic signal and increases the signal noise ratio (SNR) of the electronic signal. Increased photo detector standoff distances and sensitivities will result.

Thundat, Thomas G; Senesac, Lawrence R; Van Neste, Charles W

2013-02-19T23:59:59.000Z

125

Fingerprint detection  

DOE Patents [OSTI]

A method for detection and visualization of latent fingerprints is provided and includes contacting a substrate containing a latent print thereon with a colloidal metal composition for time sufficient to allow reaction of said colloidal metal composition with said latent print, and preserving or recording the observable print. Further, the method for detection and visualization of latent fingerprints can include contacting the metal composition-latent print reaction product with a secondary metal-containing solution for time sufficient to allow precipitation of said secondary metal thereby enhancing the visibility of the latent print, and preserving or recording the observable print.

Saunders, George C. (Rt. 1, Box 428B, Espanola, NM 87532)

1992-01-01T23:59:59.000Z

126

Detection device  

DOE Patents [OSTI]

The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

Smith, J.E.

1981-02-27T23:59:59.000Z

127

Paul Workman Cancer Research UK Cancer Therapeutics Unit  

E-Print Network [OSTI]

Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

128

Improving School Governance | 1 Improving School Governance  

E-Print Network [OSTI]

Improving School Governance | 1 Improving School Governance A Recommended Code of Governance for Schools: A flexible framework for strategic planning October 2012 Pilot version 1 #12;Improving School Governance | 2 #12;Improving School Governance | 3 This pilot version of the Recommended Code of Governance

Rambaut, Andrew

129

Cancer Research Beckman Institute  

E-Print Network [OSTI]

Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

Illinois at Urbana-Champaign, University of

130

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2011-10-04T23:59:59.000Z

131

Id-1 and Id-2 genes and products as markers of epithelial cancer  

DOE Patents [OSTI]

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Desprez, Pierre-Yves (El Cerrito, CA); Campisi, Judith (Berkeley, CA)

2008-09-30T23:59:59.000Z

132

Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies  

SciTech Connect (OSTI)

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

2012-07-01T23:59:59.000Z

133

Detection Science  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phasesData FilesShape, Density, andagingaboutDrizzle inDetecting

134

Radon detection  

DOE Patents [OSTI]

A detector for atmospheric radon using a long range alpha detector as its sensing element is described. An electrostatic filter removes ions from ambient air, while allowing radon atoms to pass into a decay cavity. Here, radon atoms are allowed to decay, creating air ions. These air ions are drawn by a fan through a second electrostatic filter which can be activated or deactivated, and into the long range alpha detector. With the second electrostatic filter activated, no air ions are allowed to pass, and the signal output from the long range alpha detector consists of only the electronic background. With the second electrostatic filter deactivated, air ions and cosmic rays will be detected. The cosmic ray contribution can be minimized by shielding. 3 figures.

MacArthur, D.W.; Allander, K.S.; Bounds, J.A.

1994-01-25T23:59:59.000Z

135

Using Passive Cavitation Detection to Observe Postexcitation Response of Ultrasound Contrast  

E-Print Network [OSTI]

Using Passive Cavitation Detection to Observe Postexcitation Response of Ultrasound Contrast Agents, FR Email: daking3@illinois.edu Abstract-- Passive cavitation detection was used to improve. Keywords - microbubbles; postexcitation; passive cavitation detection; inertial cavitation; flow rate I

Illinois at Urbana-Champaign, University of

136

Detecting persons concealed in a vehicle  

DOE Patents [OSTI]

An improved method for detecting the presence of humans or animals concealed within in a vehicle uses a combination of the continuous wavelet transform and a ratio-based energy calculation to determine whether the motion detected using seismic sensors placed on the vehicle is due to the presence of a heartbeat within the vehicle or is the result of motion caused by external factors such as the wind. The method performs well in the presence of light to moderate ambient wind levels, producing far fewer false alarm indications. The new method significantly improves the range of ambient environmental conditions under which human presence detection systems can reliably operate.

Tucker Jr., Raymond W.

2005-03-29T23:59:59.000Z

137

Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from  

E-Print Network [OSTI]

Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

Paris-Sud XI, Université de

138

Cancer Due to Prolonged Inflammation  

E-Print Network [OSTI]

Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

Lingampalli, Nithya

2013-01-01T23:59:59.000Z

139

Fuel washout detection system  

DOE Patents [OSTI]

A system for detecting grossly failed reactor fuel by detection of particulate matter as accumulated on a filter.

Colburn, Richard P. (Pasco, WA)

1985-01-01T23:59:59.000Z

140

Bismuth 213 Cancer Treatment  

ScienceCinema (OSTI)

See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

None

2013-05-28T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Milestone Plan Process Improvement  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Milestone Plan Process Improvement Milestone Plan Process Improvement Background In response to our community's concern over the milestone plan (MP) process within the system, the...

142

Neutron Imaging Explored as Complementary Technique for Improving Cancer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the Contributions andDataNational Library of1, 2007Transmission toBeamN u

143

New nanotech invention improves effectiveness of the 'penicillin of cancer'  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the Contributions andDataNational Libraryornl.govNew imaging tool directlyNational|

144

6.21 Improving Neutron Beams for Cancer Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICS H.CarbonMarchTHEMaterials and16638

145

Role of hypoxia and hypoxia induced factors in the development of breast cancer brain metastasis  

E-Print Network [OSTI]

Here we studied the role of hypoxia and hypoxia-induced factors in the development of breast cancer brain metastasis by using ENU1564, a carcinogen-induced mammary adenocarcinoma cell line. We detected hypoxia noninvasively by using a novel...

Lungu, Gina Florentina

2009-05-15T23:59:59.000Z

146

Thyroid cancer around Chernobyl  

SciTech Connect (OSTI)

The author`s presentation on thyroid cancer around Chernobyl will focus on four different things. First will be the time trends, or the pattern of thyroid cancer occurrence before and after the accident. It is now very well known that the increase in thyroid cancer in children in several areas has been unprecedented. Second, the author discusses thyroid cancer in general and patterns of thyroid cancer around the world before the Chernobyl accident, including differences by age and pathology. Third, the author presents relatively crude analyses of risk according to dose to the thyroid gland. And last, the author attempts to contrast the findings for thyroid cancer in relation to the internal radioiodine dose in Chernobyl studies with analyses of the effects of external dose on thyroid cancer incidence. The bottom line to be developed is similar to that presented by Elaine Ron with regard to effects of external dose on thyroid cancer. The similarities between the childhood finding from Chernobyl studies and external radiation studies appear more remarkable than the differences.

Beral, V. [Univ. of Oxford (United Kingdom)

1997-03-01T23:59:59.000Z

147

Autoclaving nitrocellulose membranes to improve detection of ubiquitin immunoreactivity.  

E-Print Network [OSTI]

autoclave. Carefully disassemble blot after it has cooled. Use forceps and be careful not to tear the blot;Some additional tips... - I have observed that milk (and pure casein) is not the very best blocking-inactived bovine calf serum gave a four-fold higher signal than blocking with milk in otherwise identical

Hampton, Randy

148

Reducing emissions to improve nuclear test detection | National Nuclear  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST 800-53 National Renewable EnergyReducing

149

Building on Clues: Improving Methods to Detect and  

E-Print Network [OSTI]

;Project Overview · Problem: Limited guidance on how to collect, analyze and share counterterrorism, 1999-2009 Anti-Abortion Animal Rights Anti-Muslim Right Left Ideology/Motivation Excecuted Similar

McShea, Daniel W.

150

Unanticipated potential cancer risk near metal recycling facilities  

SciTech Connect (OSTI)

Metal recycling is an important growing industry. Prior to this study, area sources consisting of metal recycling facilities fell in a category of limited regulatory scrutiny because of assumed low levels of annual emissions. Initiating with community complaints of nuisance from smoke, dust and odor, the Houston Department of Health and Human Services (HDHHS) began a monitoring program outside metal recycler facilities and found metal particulates in outdoor ambient air at levels which could pose a carcinogenic human health risk. In a study of five similar metal recycler facilities which used a torch cutting process, air downwind and outside the facility was sampled for eight hours between 6 and 10 times each over 18 months using a mobile laboratory. Ten background locations were also sampled. Iron, manganese, copper, chromium, nickel, lead, cobalt, cadmium and mercury were detected downwind of the metal recyclers at frequencies ranging from 100% of the time for iron to 2% of the time for mercury. Of these metals, chromium, nickel, lead, cobalt, cadmium and mercury were not detected in any sample in the background. Two pairs of samples were analyzed for total chromium and hexavalent chromium to establish a ratio of the fraction of hexavalent chromium in total chromium. This fraction was used to estimate hexavalent chromium at all locations. The carcinogenic risk posed to a residential receptor from metal particulate matter concentrations in the ambient air attributed to the metal recyclers was estimated from each of the five facilities in an effort to rank the importance of this source and inform the need for further investigation. The total risk from these area sources ranged from an increased cancer risk of 1 in 1,000,000 to 6 in 10,000 using the 95th upper confidence limit of the mean of the carcinogenic metal particulate matter concentration, assuming the point of the exposure is the sample location for a residential receptor after accounting for wind direction and the number of shifts that could operate a year. Further study is warranted to better understand the metal air pollution levels in the community and if necessary, to evaluate the feasibility of emission controls and identify operational improvements and best management practices for this industry. This research adds two new aspects to the literature: identification of types and magnitude of metal particulate matter air pollutants associated with a previously unrecognized area source, metal recyclers and their potential risk to health. -- Highlights: Air monitoring study in response to community complaints found metal contamination. Metal recyclers found to potentially pose cancer from metal particulates Chromium, nickel, cobalt and cadmium samples were detected in five metal recyclers. These metals were not detected in background air samples. Estimated increased cancer risk ranges from 1 in 1,000,000 to 8 in 10,000.

Raun, Loren, E-mail: raun@rice.edu [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States)] [Department of Statistics, MS 138, Rice University, P.O. Box 1892, Houston, TX 77251-1892 (United States); Pepple, Karl, E-mail: pepple.karl@epa.gov [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States)] [State and Local Programs Group, Air Quality Policy Division, Office of Air Quality Planning and Standards, Policy, Analysis, and Communications Staff, Mail Drop C404-03, U.S. EPA, Research Triangle Park, NC 27711 (United States); Hoyt, Daniel, E-mail: hoyt.daniel@epa.gov [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States)] [Air Surveillance Section, US EPA, Region 6, 6EN-AS, 1445 Ross Avenue, Dallas, TX 75202-2733 (United States); Richner, Donald, E-mail: Donald.Richner@houstontx.gov [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Houston Department of Health and Human Services, Bureau of Pollution Control and Prevention, 7411 Park Place Blvd., Houston, TX 77087 (United States); Blanco, Arturo, E-mail: arturo.blanco@houstontx.gov [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States)] [Pollution Control and Prevention, Environmental Health Division, Houston Department of Health and Human Services, 7411 Park Place Blvd., Houston, TX 77087 (United States); Li, Jiao, E-mail: jiao.li@rice.edu [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)] [Wiess School of Natural Science, Rice University, 6100 Main St., Houston, TX 77005 (United States)

2013-07-15T23:59:59.000Z

151

Anti-HER-3 MAbs Inhibit HER-3-Mediated Signaling in Breast Cancer Cell Lines Resistant to Anti-HER-2 Antibodies  

E-Print Network [OSTI]

the biologic effects of an antibody against HER3 (a-HER3ECD ) in the invasive breast cancer cell lines MCF-7ADRAnti-HER-3 MAbs Inhibit HER-3-Mediated Signaling in Breast Cancer Cell Lines Resistant to Anti can be designed based on genomic data, to improve the selectivity for cancer cells and reduce toxicity

Ullrich, Axel

152

QUESTIONS & ANSWERS ABOUT LUNG CANCER  

E-Print Network [OSTI]

QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

153

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer  

E-Print Network [OSTI]

Despite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, ...

Cron, Kyle R.

154

Economic Improvement Districts (Indiana)  

Broader source: Energy.gov [DOE]

A legislative body may adopt an ordinance establishing an economic improvement district and an Economic Improvement Board to manage development in a respective district. The Board can choose to...

155

Evidence That New Hypnotics Cause Cancer  

E-Print Network [OSTI]

medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

Kripke, Daniel F.

2008-01-01T23:59:59.000Z

156

secondary ion detection | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ion detection secondary ion detection Leads No leads are available at this time. Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. Abstract: As a...

157

E-Print Network 3.0 - ar-negative prostate cancers Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer Summary: --22000000 58 Prostate cancer Prostate cancer...

158

Detecting and molecular profiling cancer cells in patients  

E-Print Network [OSTI]

Although tumor cells obtained from human patients by surgical biopsy, image-guided intervention, blood draws or fluid drainage (paracentesis, thoracentesis) are a valuable source for analyzing tumor cells, conventional ...

Peterson, Vanessa M. (Vanessa Marie)

2013-01-01T23:59:59.000Z

159

Spectroscopic Detection of Cervical Pre-Cancer through Radial Basis  

E-Print Network [OSTI]

, fail to achieve a concurrently high sensitivity and speci city. In vivo uorescence spectroscopy., 1994). In a Pap test, a large number of cells obtained by scraping the cervical epithelium are smeared to achieve a concurrently high sensitivity1 and high speci city2 due to both sampling and reading errors

Ghosh, Joydeep

160

Dynamic fluorescence imaging with molecular agents for cancer detection  

E-Print Network [OSTI]

emission computed tomography SUV standard uptake values SLN sentinel lymph node TK tyrosine kinase TBR target to background ratio Symbols ? pharmacokinetic parameter ? pharmacokinetic parameter )(tC BOUND concentration of dye... bound to integrin receptor either in the vascular or extravascular compartments )(tC LAREXTRAVASCU concentration of dye in extravascular space )(tC VASCULAR concentration of dye in vascular space 0 I background fluorescence intensity c k...

Kwon, Sun Kuk

2009-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Software speeds detection of diseases and cancer-treatment targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

work using conventional methods." New technology puts bioinformatics within easy reach of health-care professionals, researchers and others LOS ALAMOS, N.M., Dec. 1, 2014-Los...

162

Cough Detection and Forecasting for Radiation Treatment of Lung Cancer.  

E-Print Network [OSTI]

??In radiation therapy, a treatment plan is designed to make the delivery of radiation to a target more accurate, effective, and less damaging to surrounding (more)

Qiu, Zigang Jimmy

2010-01-01T23:59:59.000Z

163

Software speeds detection of diseases and cancer-treatment targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBiSite CulturalDepartment ofat HomeAssurance: DOE NSoftware speeds

164

Software speeds detection of diseases and cancer-treatment targets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatus Tom Fletcher,Future | Department of HowSoftware speeds

165

Aneuploidy: Cancer's Fatal Flaw?  

E-Print Network [OSTI]

Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

Williams, Bret R.

166

Advanced technologies for perimeter intrusion detection sensors  

SciTech Connect (OSTI)

The development of integrated circuit fabrication techniques and the resulting devices have contributed more to the advancement of exterior intrusion detectors and alarm assessment devices than any other technology. The availability of this technology has led to the improvements in and further development of smaller more powerful computers, microprocessors, solid state memories, solid state cameras, thermal imagers, low-power lasers, and shorter pulse width and higher frequency electronic circuitry. This paper presents information on planning a perimeter intrusion detection system, identifies the site characteristics that affect its performance, and describes improvements to perimeter intrusion detection sensors and assessment devices that have been achieved by using integrated circuit technology.

Williams, J.D.

1995-03-01T23:59:59.000Z

167

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer  

E-Print Network [OSTI]

Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

Weber, David J.

168

Discrete Packet Analysis for Improved Atmospheric Rejection on Modulated Laser Signals  

SciTech Connect (OSTI)

This slide-show discusses how the method of discrete packet analysis improves atmospheric compensation for quasi-CW fluorescence detection methods. This is key to improving remote sensing capabilities.

O'Neill, M., McKenna, I., DiBenedetto, J., Capelle, G., Trainham, R.

2012-07-19T23:59:59.000Z

169

Colorectal cancer and diet in Scotland  

E-Print Network [OSTI]

Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

Theodoratou, Evropi

2008-01-01T23:59:59.000Z

170

Improving Lives. Improving Texas. Agency Strategic Plan  

E-Print Network [OSTI]

. Williams Administration Building 7101 TAMU September 2009 College Station, TX 77843-7101 Phone: 979. In the context of this broad mission, the priorities for Extension education are: Ensure a sustainable and management. Build local capacity for economic development in Texas communities. Improve the health

171

Evolutionary Modeling of Combination Treatment Strategies To Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer  

E-Print Network [OSTI]

of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, Palo Alto, California populations. Our mathematical model predicts the population dynamics of mixtures of sensitive and resistant

172

Effective Conveyor Belt Inspection for Improved Mining Productivity  

SciTech Connect (OSTI)

This document details progress on the project entitled ''Effective Conveyor Belt Inspection for Improved Mining Productivity'' during the period from November 15, 2004 to May 14, 2004. Highlights include fabrication of an improved LED lightbar, fabrication of a line-scan sensor head for the Smart-Camera based prototype, and development of prototype vulcanized splice detection algorithms.

Chris Fromme

2006-06-01T23:59:59.000Z

173

Open problem: Dynamic Relational Models for Improved Hazardous Weather Prediction  

E-Print Network [OSTI]

. Current weather radar detection and prediction sys- tems primarily rely on numerical models. We proposeOpen problem: Dynamic Relational Models for Improved Hazardous Weather Prediction Amy McGovern1, #12;Dynamic Relational Models for Improved Hazardous Weather Prediction Radar velocity Radar

McGovern, Amy

174

Cell Senescence: Aging and Cancer  

ScienceCinema (OSTI)

Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

Campisi, Judith

2013-05-29T23:59:59.000Z

175

Revolution in Detection Affairs  

SciTech Connect (OSTI)

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

Stern W.

2013-11-02T23:59:59.000Z

176

Object Detection Combining Recognition and Segmentation  

E-Print Network [OSTI]

segmentation. There are two main steps in this method: a hypothesis generation step and a verification step. In the top-down hy- pothesis generation step, we design an improved Shape Context feature, which is more. We develop an object detection method combining top-down recog- nition with bottom-up image

Plotkin, Joshua B.

177

Improved solid aerosol generator  

DOE Patents [OSTI]

An improved solid aerosol generator used to produce a gas borne stream of dry, solid particles of predetermined size and concentration. The improved solid aerosol generator nebulizes a feed solution of known concentration with a flow of preheated gas and dries the resultant wet heated aerosol in a grounded, conical heating chamber, achieving high recovery and flow rates. 2 figs.

Prescott, D.S.; Schober, R.K.; Beller, J.

1988-07-19T23:59:59.000Z

178

Hindawi Publishing Corporation Prostate Cancer  

E-Print Network [OSTI]

Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

Ahn, Hongshik

179

Interior intrusion detection systems  

SciTech Connect (OSTI)

The purpose of this NUREG is to present technical information that should be useful to NRC licensees in designing interior intrusion detection systems. Interior intrusion sensors are discussed according to their primary application: boundary-penetration detection, volumetric detection, and point protection. Information necessary for implementation of an effective interior intrusion detection system is presented, including principles of operation, performance characteristics and guidelines for design, procurement, installation, testing, and maintenance. A glossary of sensor data terms is included. 36 figs., 6 tabs.

Rodriguez, J.R.; Matter, J.C. (Sandia National Labs., Albuquerque, NM (United States)); Dry, B. (BE, Inc., Barnwell, SC (United States))

1991-10-01T23:59:59.000Z

180

Recent Improvements in DDT  

E-Print Network [OSTI]

This paper will report new developments and recent improvements to DDT. "Window DDT" now will remember undefined symbols and define them on a later command. Using sequence breaks, it can change the contents of memory while ...

Edwards, D.J.

1963-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer  

E-Print Network [OSTI]

Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

2006-01-01T23:59:59.000Z

182

Estimating radiogenic cancer risks  

SciTech Connect (OSTI)

This document presents a revised methodology for EPA`s estimation of cancer risks due to low-LET radiation exposures in light of information that has become available since the publication of BIER III, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model is one in which the age-specific relative risk coefficients are obtained by taking the geometric mean of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks from Japan to the U.S. (multiplicative and NIH projection methods). Using 1980 U.S. vital statistics, the risk models are applied to estimate organ-specific risks, per unit dose, for a stationary population.

NONE

1994-06-01T23:59:59.000Z

183

Improving steam turbine efficiency  

SciTech Connect (OSTI)

This paper describes the condition of a significant number of fossil steam turbines operating in the United States and the maintenance practices used to improve their performance. Through the use of steam path audits conducted by the authors` company and by several utilities, a large data base of information on turbine heat rate, casing efficiency, and maintenance practices is available to help the power generation industry understand how different maintenance practices and steam path damage impact turbine performance. The data base reveals that turbine cycle heat rate is typically 5.23% poorer than design just prior to major outages. The degraded condition of steam turbines presents an opportunity for utilities to improve heat rate and reduce emissions without increasing fuel costs. The paper describes what losses typically contribute to the 5.23% heat rate degradation and how utilities can recover steam turbine performance through maintenance actions aimed at improving steam path efficiency.

Cioffi, D.H.; Mitchell, D.R.; Whitecar, S.C. [Encotech, Inc., Schenectady, NY (United States)

1995-06-01T23:59:59.000Z

184

EMSL - secondary ion detection  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

secondary-ion-detection en Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. http:www.emsl.pnl.govemslwebpublicationsmagnesium-behavior-and-struc...

185

Think Detection. Think Prevention.  

E-Print Network [OSTI]

Think Detection. Think Prevention. Think Activity. Office Ergonomics: #12;The Case of Mr. Z Mr. Z..........................................................................................7 Think Prevention. Ergonomics .............................................................11 What is office ergonomics?................................................................11 Making Your

Calgary, University of

186

ACCELERATED IMPROVEMENT A CONCENTRATED APPROACH  

E-Print Network [OSTI]

ACCELERATED IMPROVEMENT A CONCENTRATED APPROACH FOR CONTINUOUS IMPROVEMENT #12;Accelerated.quality.wisc.edu O F F I C E O F Q U A L I T Y I M P R O V E M E N T Accelerated Improvement This guide to improving resources. You will find helpful information needed to conduct an Accelerated Improvement project

Shapiro, Vadim

187

Childhood Cancer Tracking Initiative in Massachusetts  

E-Print Network [OSTI]

Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

188

Cancer Therapies: A Bane and a Boon  

E-Print Network [OSTI]

on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

Neogi, Sushrita

2012-01-01T23:59:59.000Z

189

Diet, MicroRNAs and Prostate Cancer  

E-Print Network [OSTI]

deregulation in human cancer. Cell Cycle. 2008;7:26436. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

2010-01-01T23:59:59.000Z

190

Improved vortex reactor system  

DOE Patents [OSTI]

An improved vortex reactor system for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor.

Diebold, James P. (Lakewood, CO); Scahill, John W. (Evergreen, CO)

1995-01-01T23:59:59.000Z

191

CAMPUS IMPROVEMENT PROGRAM 201420  

E-Print Network [OSTI]

(CIP) 2014­20? The Campus Improvement Program (CIP) is a concept proposal for the delivery of new-Darlington campus to 2020 through land uses and building envelopes. The CIP is not a proposal for the detailed design and construction of new buildings. See point 9. 2. What are the objectives of the CIP? The CIP

Viglas, Anastasios

192

Planetary Nebulae Detection  

E-Print Network [OSTI]

layers develop deep convective zone, surface expands, mass loss due to stellar wind · Star moves from tip1 Planetary Nebulae · Detection · Distribution in the Galaxy · Central Stars · Evolution · Bipolar to dust) · Difficult to detect in radio (fainter than H II regions) · Projected number based on surveys

Crenshaw, Michael

193

Array for detecting microbes  

DOE Patents [OSTI]

The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.

Andersen, Gary L.; DeSantis, Todd D.

2014-07-08T23:59:59.000Z

194

Lean blowoff detection sensor  

SciTech Connect (OSTI)

Apparatus and method for detecting incipient lean blowoff conditions in a lean premixed combustion nozzle of a gas turbine. A sensor near the flame detects the concentration of hydrocarbon ions and/or electrons produced by combustion and the concentration monitored as a function of time are used to indicate incipient lean blowoff conditions.

Thornton, Jimmy (Morgantown, WV); Straub, Douglas L. (Morgantown, WV); Chorpening, Benjamin T. (Morgantown, WV); Huckaby, David (Morgantown, WV)

2007-04-03T23:59:59.000Z

195

Mathematical Toolkit Unlocks Some Cancer Secrets  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

196

Improved gaseous leak detector  

DOE Patents [OSTI]

In a short path length mass-spectrometer type of helium leak detector wherein the helium trace gas is ionized, accelerated and deflected onto a particle counter, an arrangement is provided for converting the detector to neon leak detection. The magnetic field of the deflection system is lowered so as to bring the nonlinear fringe area of the magnetic field across the ion path, thereby increasing the amount of deflection of the heavier neon ions.

Juravic, F.E. Jr.

1983-10-06T23:59:59.000Z

197

Improved solar heating systems  

DOE Patents [OSTI]

An improved solar heating system is described in which the incident radiation of the sun is absorbed on collector panels, transferred to a storage unit and then distributed as heat for a building and the like. The improvement is obtained by utilizing a storage unit comprising separate compartments containing an array of materials having different melting points ranging from 75 to 180/sup 0/F. The materials in the storage system are melted in accordance with the amount of heat absorbed from the sun and then transferred to the storage system. An efficient low volume storage system is provided by utilizing the latent heat of fusion of the materials as they change states in storing ad releasing heat for distribution.

Schreyer, J.M.; Dorsey, G.F.

1980-05-16T23:59:59.000Z

198

Improved vortex reactor system  

DOE Patents [OSTI]

An improved vortex reactor system is described for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor. 12 figs.

Diebold, J.P.; Scahill, J.W.

1995-05-09T23:59:59.000Z

199

Improving haul truck productivity  

SciTech Connect (OSTI)

The paper reviews developments in payload management and cycle times. These were discussed at a roundtable held at the Haulage and Loading 2007 conference held in May in Phoenix, AZ, USA. Several original equipment manufacturers (OEMs) explaind what their companies were doing to improve cycle times for trucks, shovels and excavators used in surface coal mining. Quotations are given from Dion Domaschenz of Liebherr and Steve Plott of Cat Global Mining. 4 figs.

Fiscor, S.

2007-06-15T23:59:59.000Z

200

Improving biofuel production | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for planning experimental workImproving Reusebiofuel

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Improving catalysts | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for planning experimental workImproving

202

Infrastructure Improvements - SRSCRO  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for planningtoAInfrastructure Improvements As the

203

Breakthrough: Fighting Cancer with Nanoparticles  

SciTech Connect (OSTI)

Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

Rozhkova, Elena

2012-01-01T23:59:59.000Z

204

Breakthrough: Fighting Cancer with Nanoparticles  

ScienceCinema (OSTI)

Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

Rozhkova, Elena

2013-04-19T23:59:59.000Z

205

A toolkit for detecting technical surprise.  

SciTech Connect (OSTI)

The detection of a scientific or technological surprise within a secretive country or institute is very difficult. The ability to detect such surprises would allow analysts to identify the capabilities that could be a military or economic threat to national security. Sandia's current approach utilizing ThreatView has been successful in revealing potential technological surprises. However, as data sets become larger, it becomes critical to use algorithms as filters along with the visualization environments. Our two-year LDRD had two primary goals. First, we developed a tool, a Self-Organizing Map (SOM), to extend ThreatView and improve our understanding of the issues involved in working with textual data sets. Second, we developed a toolkit for detecting indicators of technical surprise in textual data sets. Our toolkit has been successfully used to perform technology assessments for the Science & Technology Intelligence (S&TI) program.

Trahan, Michael Wayne; Foehse, Mark C.

2010-10-01T23:59:59.000Z

206

Track 10: Feedback and Improvement  

Broader source: Energy.gov [DOE]

ISM Workshop Presentations Knoxville Convention Center, Knoxville, TN August 2009 Track 10: Feedback and Improvement

207

Explosive Detection Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To standardize and accelerate implementation of the Department of Energy (DOE) explosive detection program. DOE N 251.40, dated 5/3/01, extends this directive until 12/31/01.

2000-10-26T23:59:59.000Z

208

Detection of counterfeit currency  

DOE Patents [OSTI]

A method of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1250 namometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency.

Burns, Donald A. (Los Alamos, NM)

1998-01-01T23:59:59.000Z

209

Idaho Explosive Detection System  

ScienceCinema (OSTI)

Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

Klinger, Jeff

2013-05-28T23:59:59.000Z

210

Bolt failure detection  

DOE Patents [OSTI]

Bolts of a liquid metal fast breeder reactor, each bolt provided with an internal chamber filled with a specific, unique radioactive tag gas. Detection of the tag gas is indicative of a crack in an identifiable bolt.

Sutton, Jr., Harry G. (Pittsburgh, PA)

1984-01-01T23:59:59.000Z

211

Termination Detection of Local Computations  

E-Print Network [OSTI]

Termination Detection of Local Computations Emmanuel Godard1 , Yves Metivier2 and Gerard Tel3 1 is glob- ally finished. This paper investigates the problem of the detection of the termination of local computations. We define four types of termination detection: no detection, detection of the local termination

Paris-Sud XI, Universit de

212

Skin cancer is the most com-mon form of cancer in the United  

E-Print Network [OSTI]

Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

213

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer  

E-Print Network [OSTI]

Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

Salzman, Daniel

214

Cancer Immunol Immunother . Author manuscript Anti-HER2 vaccines: new prospects for breast cancer therapy  

E-Print Network [OSTI]

Cancer Immunol Immunother . Author manuscript Page /1 18 Anti-HER2 vaccines: new prospects for breast cancer therapy Maha Zohra Ladjemi 1 , William Jacot 2 , Thierry Chard sè 1 , Andr P legriné è 1 cancer accounts for more than 400.000 new cancer cases and more than 130.000 cancer deaths in Europe

Paris-Sud XI, Université de

215

miRNA-205 affects infiltration and metastasis of breast cancer  

SciTech Connect (OSTI)

Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

Wang, Zhouquan [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China) [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China); Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 (China); Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China)] [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China); Ren, Hong, E-mail: renhongs2000@yahoo.com.cn [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China)] [Department of Chest Surgery, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710061 (China)

2013-11-08T23:59:59.000Z

216

Improved cycling cryopump  

DOE Patents [OSTI]

The present invention is designed to achieve continuous high efficiency cryopumping of a vacuum vessel by improving upon and combining in a novel way the cryopumping in a novel way the cryopumping methods. The invention consists of a continuous operation cryopump, with movable louvres, with a high efficiency pumping apparatus. The pumping apparatus includes three cryogenic tubes. They are constructed of a substance of high thermal conductivity, such as aluminum and their exterior surfaces are cryogenic condensing surfaces. Through their interior liquid or gaseous helium from two reservoirs can be made to flow, alternately promoting extreme cooling or allowing some warming.

Batzer, T.H.; Call, W.R.

1984-12-04T23:59:59.000Z

217

ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION  

E-Print Network [OSTI]

, (-)-epigallocatechin-3-gallate (EGCG) from Green tea, Irresa and resveratrol have been shown to exhibit cancer

218

CANCER RISKS AM I AT RISK?  

E-Print Network [OSTI]

CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

Hardy, Christopher R.

219

BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY  

E-Print Network [OSTI]

BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

Spence, Harlan Ernest

220

Making a difference... A National Cancer  

E-Print Network [OSTI]

Making a difference... A National Cancer Research Institute (NCRI) Accredited Trials Unit Contacts Cancer Research UK Clinical Trials Unit School of Cancer Sciences University of Birmingham Edgbaston. Funding The CRCTU receives core funding from Cancer Research UK and has successfully obtained project

Birmingham, University of

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Contact Details Journeying Beyond Breast Cancer  

E-Print Network [OSTI]

Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

Espinosa, Horacio D.

222

Nanoscale mapping and organization analysis of target proteins on cancer cells from B-cell lymphoma patients  

SciTech Connect (OSTI)

CD20, a membrane protein highly expressed on most B-cell lymphomas, is an effective target demonstrated in clinical practice for treating B-cell non-Hodgkin's lymphoma (NHL). Rituximab is a monoclonal antibody against CD20. In this work, we applied atomic force microscopy (AFM) to map the nanoscale distribution of CD20 molecules on the surface of cancer cells from clinical B-cell NHL patients under the assistance of ROR1 fluorescence recognition (ROR1 is a specific cell surface marker exclusively expressed on cancer cells). First, the ROR1 fluorescence labeling experiments showed that ROR1 was expressed on cancer cells from B-cell lymphoma patients, but not on normal cells from healthy volunteers. Next, under the guidance of ROR1 fluorescence, the rituximab-conjugated AFM tips were moved to cancer cells to image the cellular morphologies and detect the CD20-rituximab interactions on the cell surfaces. The distribution maps of CD20 on cancer cells were constructed by obtaining arrays of (1616) force curves in local areas (500500 nm{sup 2}) on the cell surfaces. The experimental results provide a new approach to directly investigate the nanoscale distribution of target protein on single clinical cancer cells. - Highlights: Cancer cells were recognized from healthy cells by ROR1 fluorescence labeling. The nanoscale distribution of CD20 on cancer cells was characterized. The distribution of CD20 was non-uniform on the surface of cancer cells.

Li, Mi [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Xiao, Xiubin [Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing 100071 (China); Liu, Lianqing, E-mail: lqliu@sia.cn [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); Xi, Ning, E-mail: xin@egr.msu.edu [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong (China); Wang, Yuechao; Dong, Zaili [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); Zhang, Weijing, E-mail: zhangwj3072@163.com [Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing 100071 (China)

2013-11-01T23:59:59.000Z

223

Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)  

ScienceCinema (OSTI)

In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

2011-10-04T23:59:59.000Z

224

OSTEOBLAST ADHESION OF BREAST CANCER CELLS WITH SCANNING ACOUSTIC MICROSCOPY  

SciTech Connect (OSTI)

Breast cancer frequently metastasizes to the bone. Upon colonizing bone tissue, the cancer cells stimulate osteoclasts (cells that break bone down), resulting in large lesions in the bone. The breast cancer cells also affect osteoblasts (cells that build new bone). Conditioned medium was collected from a bone-metastatic breast cancer cell line, MDA-MB-231, and cultured with an immature osteoblast cell line, MC3T3-E1. Under these conditions the osteoblasts acquired a changed morphology and appeared to adherer in a different way to the substrate and to each other. To characterize cell adhesion, MC3T3-E1 osteoblasts were cultured with or without MDA-MB-231 conditioned medium for two days, and then assayed with a mechanical scanning acoustic reflection microscope (SAM). The SAM indicated that in normal medium the MC3T3-E1 osteoblasts were firmly attached to their plastic substrate. However, MC3T3-E1 cells cultured with MDA-MB-231 conditioned medium displayed both an abnormal shape and poor adhesion at the substrate interface. The cells were fixed and stained to visualize cytoskeletal components using optical microscopic techniques. We were not able to observe these differences until the cells were quite confluent after 7 days of culture. However, using the SAM, we were able to detect these changes within 2 days of culture with MDA-MB-231 conditioned medium

Chiaki Miyasaka; Robyn R. Mercer; Andrea M. Mastro; Ken L. Telschow

2005-03-01T23:59:59.000Z

225

Surface-engineered substrates for improved human pluripotent stem cell culture under  

E-Print Network [OSTI]

modification of typical cell culture plastics to define a favorable surface environment for human pluripotentSurface-engineered substrates for improved human pluripotent stem cell culture under fully defined of Chemical Engineering, d David H. Koch Institute for Integrative Cancer Research, and e Harvard

Saha, Krishanu

226

Lake Improvement District Law and County Lake Improvement Program (Minnesota)  

Broader source: Energy.gov [DOE]

Lake Improvement Districts may be established by county boards in order to improve the quality of water in lakes; provide for reasonable assurance of water quantity in lakes, where feasible and...

227

The Cancer Genome Atlas Pan-Cancer analysis project  

E-Print Network [OSTI]

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

Lander, Eric S.

228

Temperature differential detection device  

DOE Patents [OSTI]

A temperature differential detection device for detecting the temperature differential between predetermined portions of a container wall is disclosed as comprising a Wheatstone bridge circuit for detecting resistance imbalance with a first circuit branch having a first elongated wire element mounted in thermal contact with a predetermined portion of the container wall, a second circuit branch having a second elongated wire element mounted in thermal contact with a second predetermined portion of a container wall with the wire elements having a predetermined temperature-resistant coefficient, an indicator interconnected between the first and second branches remote from the container wall for detecting and indicating resistance imbalance between the first and second wire elements, and connector leads for electrically connecting the wire elements to the remote indicator in order to maintain the respective resistance value relationship between the first and second wire elements. The indicator is calibrated to indicate the detected resistance imbalance in terms of a temperature differential between the first and second wall portions. 2 figs.

Girling, P.M.

1986-04-22T23:59:59.000Z

229

Volumetric modulated arc radiotherapy for esophageal cancer  

SciTech Connect (OSTI)

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

Vivekanandan, Nagarajan, E-mail: viveknaren@hotmail.com [Department of Medical Physics, Cancer Institute, Chennai (India); Sriram, Padmanaban; Syam Kumar, S.A.; Bhuvaneswari, Narayanan; Saranya, Kamalakannan [Department of Medical Physics, Cancer Institute, Chennai (India)

2012-04-01T23:59:59.000Z

230

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer  

E-Print Network [OSTI]

2007;318:11081113. 8. CancerGenomeAtlasNetwork. somaticmutationinhumancancergenomes. Nature2007;446:153158. 11. KatohM. Cancergenomicsandgeneticsof

Spellman, Paul T.

2011-01-01T23:59:59.000Z

231

Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.  

E-Print Network [OSTI]

Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

2012-01-01T23:59:59.000Z

232

School Response to Families with Children with Cancer  

E-Print Network [OSTI]

Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

Nielsen, Shelley Lynn

2010-01-01T23:59:59.000Z

233

Stromal Modulation of Radiation Carcinogenesis in Breast Cancer  

E-Print Network [OSTI]

receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

Nguyen, David Hiendat Hua

2011-01-01T23:59:59.000Z

234

Technology "Relay Race" Against Cancer | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

GE Scientists in Technology "Relay Race" Against Cancer GE Scientists in Technology "Relay Race" Against Cancer GE technologies being developed to impact every stage of cancer...

235

Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk  

E-Print Network [OSTI]

cigarette smoking, and the risk of breast cancer. Cancerand breast cancer risk. JAMA Ambrosone, C.B. , Kropp, S. ,genotypes, and breast cancer risk: pooled analysis and meta-

2009-01-01T23:59:59.000Z

236

Composition for detecting uranyl  

DOE Patents [OSTI]

The present invention relates to an indicator composition for use in spectrophotometric detection of a substance in a solution, and a method for making the composition. Useful indicators are sensitive to the particular substance being measured, but are unaffected by the fluid and other chemical species that may be present in the fluid. Optical indicators are used to measure the uranium concentration of process solutions in facilities for extracting uranium from ores, production of nuclear fuels, and reprocessing of irradiated fuels. The composition comprises an organohalide covalently bonded to an indicator for the substance, in such a manner that the product is itself an indicator that provides increased spectral resolution for detecting the substance. The indicator is preferably arsenazo III and the organohalide is preferably cyanuric chloride. These form a composition that is ideally suited for detecting uranyl.

Baylor, L.C.; Stephens, S.M.

1994-01-01T23:59:59.000Z

237

Error detection method  

DOE Patents [OSTI]

An apparatus, program product, and method that run an algorithm on a hardware based processor, generate a hardware error as a result of running the algorithm, generate an algorithm output for the algorithm, compare the algorithm output to another output for the algorithm, and detect the hardware error from the comparison. The algorithm is designed to cause the hardware based processor to heat to a degree that increases the likelihood of hardware errors to manifest, and the hardware error is observable in the algorithm output. As such, electronic components may be sufficiently heated and/or sufficiently stressed to create better conditions for generating hardware errors, and the output of the algorithm may be compared at the end of the run to detect a hardware error that occurred anywhere during the run that may otherwise not be detected by traditional methodologies (e.g., due to cooling, insufficient heat and/or stress, etc.).

Olson, Eric J.

2013-06-11T23:59:59.000Z

238

Solar system fault detection  

DOE Patents [OSTI]

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, R.B.; Pruett, J.C. Jr.

1984-05-14T23:59:59.000Z

239

Solar system fault detection  

DOE Patents [OSTI]

A fault detecting apparatus and method are provided for use with an active solar system. The apparatus provides an indication as to whether one or more predetermined faults have occurred in the solar system. The apparatus includes a plurality of sensors, each sensor being used in determining whether a predetermined condition is present. The outputs of the sensors are combined in a pre-established manner in accordance with the kind of predetermined faults to be detected. Indicators communicate with the outputs generated by combining the sensor outputs to give the user of the solar system and the apparatus an indication as to whether a predetermined fault has occurred. Upon detection and indication of any predetermined fault, the user can take appropriate corrective action so that the overall reliability and efficiency of the active solar system are increased.

Farrington, Robert B. (Wheatridge, CO); Pruett, Jr., James C. (Lakewood, CO)

1986-01-01T23:59:59.000Z

240

Improved Lattice Radial Quantization  

E-Print Network [OSTI]

Lattice radial quantization was proposed in a recent paper by Brower, Fleming and Neuberger[1] as a nonperturbative method especially suited to numerically solve Euclidean conformal field theories. The lessons learned from the lattice radial quantization of the 3D Ising model on a longitudinal cylinder with 2D Icosahedral cross-section suggested the need for an improved discretization. We consider here the use of the Finite Element Methods(FEM) to descretize the universally-equivalent $\\phi^4$ Lagrangian on $\\mathbb R \\times \\mathbb S^2$. It is argued that this lattice regularization will approach the exact conformal theory at the Wilson-Fisher fixed point in the continuum. Numerical tests are underway to support this conjecture.

Richard C. Brower; Michael Cheng; George T. Fleming

2014-07-28T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Method of detecting genetic deletions identified with chromosomal abnormalities  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acids probes are typically of a complexity greater tha 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particlularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar ut genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W; Pinkel, Daniel; Tkachuk, Douglas

2013-11-26T23:59:59.000Z

242

Chromosome-specific staining to detect genetic rearrangements  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W.; Pinkel, Daniel; Tkachuk, Douglas; Westbrook, Carol

2013-04-09T23:59:59.000Z

243

Method of detecting genetic translocations identified with chromosomal abnormalities  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Tkachuk, Douglas (Livermore, CA)

2001-01-01T23:59:59.000Z

244

Differential expression of intronless carcinoma-associated antigen GA733-1 in two distinct classes of human breast cancer cell lines  

SciTech Connect (OSTI)

Using differential hybridization, we have isolated a 0.8-kb GA733-1 cDNA clone which was selectively expressed in the MCF-7 and Au565 breast cancer cell lines but not in MB231 cells. Subsequent studies with 10 additional breast cancer cell lines have allowed us to identify two classes of breast cancer cell lines that display distinct expression of the GA733-1 antigen as well as other cellular parameters. The six GA733-1{sup +} cell lines (MCF-7, ZR75-1, MB468, Au565, BJ015, and MB453) exhibit a spherical or cuboidal shape. These cells tend to grow in clusters and display extensive cell-cell connections. In contrast, all GA733-1{sup -} cells (MB435s, MB231, MB436, MB157, BT549, and Hs578T) assume a more elongated, fibroblast-like morphology and grow in a discrete, uniform pattern. These results are consistent with previous findings suggesting the GA733 gene products function as cell-cell adhesion molecules. Generally, the GA733-1{sup -} cells actively produce lipid vesicles, whereas the GA733-1{sup +} cells are virtually inactive in lipid production. In addition, all six GA733-1{sup +} cell lines express keratin 19, which is only weakly expressed or not detectable in the GA733-1{sup -} cells. Comparative analysis of our results with previous studies has shown that GA733-1 expression is inversely related to vimentin expression and that the GA733-1{sup -}/VIM{sup +} cells display a much higher invasive propensity than the GA733-1{sup +}/VIM{sup -} lines in both in vitro and in vivo assays. However, there seems no obvious correlation of GA733-1 expression with that of estrogen receptor (ER) except that no GA733-1{sup -} cell lines express the receptor. The combination of these four parameters (ER, GA733-1, vimentin, and keratin 19), should contribute to the reliability of the histological grading of breast cancer and may provide a basis for improved treatment of breast cancer.

Xie, Bei; Horio, Murao; Collart, F.R. [and others

1995-07-28T23:59:59.000Z

245

Regulatory Streamlining and Improvement  

SciTech Connect (OSTI)

The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and Development: This area of interest relates directly to helping maximize production of domestic oil and natural gas resources, including areas that are under explored or have not been adequately defined.

Mark A. Carl

2006-07-11T23:59:59.000Z

246

Fiber Optic Micro-endoscopy for Detection of Bacteria in Early Stages of Infection  

E-Print Network [OSTI]

. have built a wide field Light Emitting Diode (LED) illumination based, 1 mm diameter fiber bundle micro-endoscope capable of sub-cellular resolution imaging (4 ?m resolution with 750 ?m field of view) for pre-cancer detection in the oral mucosa [16...

Mufti, Nooman Sadat

2012-02-14T23:59:59.000Z

247

Singlet Oxygen Singlet oxygen generation and detection are growing fields with applications in such areas as  

E-Print Network [OSTI]

Singlet Oxygen Singlet oxygen generation and detection are growing fields with applications in such areas as cancer treatment, photosensitized oxidations, and biomolecular degradation. Ground state oxygen state of an oxygen molecule is a singlet state, which can readily react with other singlet molecules

Wells, Mathew G. - Department of Physical and Environmental Sciences, University of Toronto

248

Bursts detected and NOT detected by EGRET imaging spark chambers  

SciTech Connect (OSTI)

EGRET has detected the highest energy emission from gamma-ray bursts. Only a few bursts have been detected either coincident or just following the BATSE detected emission. These bursts are among the brightest bursts detected by BATSE. The EGRET fluxes, including upper limits, are consistent with extrapolations for all the burst spectra measured with Comptel.

Dingus, Brenda L. [University of Utah, Salt Lake City, Utah 84112 (United States); Catelli, Jennifer R. [University of Maryland, College Park, Maryland 20742 (United States); NASA/GSFC, Greenbelt, Maryland 20771 (United States); Schneid, E. J. [Northrop-Grummann, MS A01-26, Bethpage, New York 11714 (United States)

1998-05-16T23:59:59.000Z

249

Occupancy Based Fault Detection on Building Level - a Feasibility Study  

E-Print Network [OSTI]

-going commissioning and fault detection and diagnostics (FDD) has been performed to improve the current situation of building problems by comparing measured building performance with design predictions [Portland 2003]. For fault detection, different methods... conference on building commissioning, Portland Energy Conservation. Portland. 2003. Methods for automated and continuous commissioning of building systems. US department of commerce, Portland energy conservation inc. Schijndel, A.W.M. van, 2008...

Tuip, B.; Houten, M.; Trcka, M.; Hensen, M.

2010-01-01T23:59:59.000Z

250

Roadway Improvement Project Cost Allocation  

E-Print Network [OSTI]

Roadway Improvement Project Cost Allocation CTS 21st Annual Transportation Research Conference costs #12;Potential Applications · Roadway Project Feasibility Studies ­ Identified potential roadway infrastructure improvement ­ Documentation of estimated project costs ­ Determine property assessments

Minnesota, University of

251

Detection of neutrinos  

DOE Patents [OSTI]

A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

Fischbach, Ephraim; Jenkins, Jere

2014-02-04T23:59:59.000Z

252

Detection of solar events  

DOE Patents [OSTI]

A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

Fischbach, Ephraim; Jenkins, Jere

2013-08-27T23:59:59.000Z

253

STANFORD CANCER CENTER Patient Treatment  

E-Print Network [OSTI]

PRESCRIBED: Printed on 100% post-consumer recycled paper, with vegetable-based inks. #12;STANFORD CANCER any animal feces (i.e., cat litter) of any kind. OK to pet your animal, just wash your hands, keep

Ford, James

254

Antibody engineering for cancer therapy  

E-Print Network [OSTI]

Antibodies targeting various tumor-associated antigens have been developed successfully to treat cancer. In this Thesis, novel antibodies and antibody-conjugate against two tumor antigens, AF-20 antigen and human aspartyl ...

Yeung, Yik Andy

2005-01-01T23:59:59.000Z

255

3D-FFT for Signature Detection in LWIR Images  

SciTech Connect (OSTI)

Improvements in analysis detection exploitation are possible by applying whitened matched filtering within the Fourier domain to hyperspectral data cubes. We describe an implementation of a Three Dimensional Fast Fourier Transform Whitened Matched Filter (3DFFTMF) approach and, using several example sets of Long Wave Infra Red (LWIR) data cubes, compare the results with those from standard Whitened Matched Filter (WMF) techniques. Since the variability in shape of gaseous plumes precludes the use of spatial conformation in the matched filtering, the 3DFFTMF results were similar to those of two other WMF methods. Including a spatial low-pass filter within the Fourier space can improve signal to noise ratios and therefore improve detection limit by facilitating the mitigation of high frequency clutter. The improvement only occurs if the low-pass filter diameter is smaller than the plume diameter.

Medvick, Patricia A.; Lind, Michael A.; Mackey, Patrick S.; Nuffer, Lisa L.; Foote, Harlan P.

2007-11-20T23:59:59.000Z

256

Portable raman explosives detection  

SciTech Connect (OSTI)

Recent advances in portable Raman instruments have dramatically increased their application to emergency response and forensics, as well as homeland defense. This paper reviews the relevant attributes and disadvantages of portable Raman spectroscopy, both essentially and instrumentally, to the task of explosives detection in the field.

Moore, David Steven [Los Alamos National Laboratory; Scharff, Robert J [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

257

Nitrogen dioxide detection  

DOE Patents [OSTI]

Method and apparatus for detecting the presence of gaseous nitrogen dioxide and determining the amount of gas which is present. Though polystyrene is normally an insulator, it becomes electrically conductive in the presence of nitrogen dioxide. Conductance or resistance of a polystyrene sensing element is related to the concentration of nitrogen dioxide at the sensing element.

Sinha, Dipen N. (Los Alamos, NM); Agnew, Stephen F. (Los Alamos, NM); Christensen, William H. (Buena Park, CA)

1993-01-01T23:59:59.000Z

258

Liquid detection circuit  

DOE Patents [OSTI]

Herein is a circuit which is capable of detecting the presence of liquids, especially cryogenic liquids, and whose sensor will not overheat in a vacuum. The circuit parameters, however, can be adjusted to work with any liquid over a wide range of temperatures.

Regan, Thomas O. (North Aurora, IL)

1987-01-01T23:59:59.000Z

259

Detection of counterfeit currency  

DOE Patents [OSTI]

A method is disclosed of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1,250 nanometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency. 18 figs.

Burns, D.A.

1998-05-26T23:59:59.000Z

260

Refines Efficiency Improvement  

SciTech Connect (OSTI)

Refinery processes that convert heavy oils to lighter distillate fuels require heating for distillation, hydrogen addition or carbon rejection (coking). Efficiency is limited by the formation of insoluble carbon-rich coke deposits. Heat exchangers and other refinery units must be shut down for mechanical coke removal, resulting in a significant loss of output and revenue. When a residuum is heated above the temperature at which pyrolysis occurs (340 C, 650 F), there is typically an induction period before coke formation begins (Magaril and Aksenova 1968, Wiehe 1993). To avoid fouling, refiners often stop heating a residuum before coke formation begins, using arbitrary criteria. In many cases, this heating is stopped sooner than need be, resulting in less than maximum product yield. Western Research Institute (WRI) has developed innovative Coking Index concepts (patent pending) which can be used for process control by refiners to heat residua to the threshold, but not beyond the point at which coke formation begins when petroleum residua materials are heated at pyrolysis temperatures (Schabron et al. 2001). The development of this universal predictor solves a long standing problem in petroleum refining. These Coking Indexes have great potential value in improving the efficiency of distillation processes. The Coking Indexes were found to apply to residua in a universal manner, and the theoretical basis for the indexes has been established (Schabron et al. 2001a, 2001b, 2001c). For the first time, a few simple measurements indicates how close undesired coke formation is on the coke formation induction time line. The Coking Indexes can lead to new process controls that can improve refinery distillation efficiency by several percentage points. Petroleum residua consist of an ordered continuum of solvated polar materials usually referred to as asphaltenes dispersed in a lower polarity solvent phase held together by intermediate polarity materials usually referred to as resins. The Coking Indexes focus on the amount of these intermediate polarity species since coke formation begins when these are depleted. Currently the Coking Indexes are determined by either titration or solubility measurements which must be performed in a laboratory. In the current work, various spectral, microscopic, and thermal techniques possibly leading to on-line analysis were explored for measuring the Coking Indexes.

WRI

2002-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This report describes work performed during the third and final year of the project, ''Conformance Improvement Using Gels.'' Corefloods revealed throughput dependencies of permeability reduction by polymers and gels that were much more prolonged during oil flow than water flow. This behavior was explained using simple mobility ratio arguments. A model was developed that quantitatively fits the results and predicts ''clean up'' times for oil productivity when production wells are returned to service after application of a polymer or gel treatment. X-ray computed microtomography studies of gels in strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene suggested that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than gel-ripping or gel-displacement mechanisms. In contrast, analysis of data from the University of Kansas suggests that the gel-ripping or displacement mechanisms are more important in more permeable, strongly water-wet sandpacks. These findings help to explain why aqueous gels can reduce permeability to water more than to oil under different conditions. Since cement is the most commonly used material for water shutoff, we considered when gels are preferred over cements. Our analysis and experimental results indicated that cement cannot be expected to completely fill (top to bottom) a vertical fracture of any width, except near the wellbore. For vertical fractures with apertures less than 4 mm, the cement slurry will simply not penetrate very far into the fracture. For vertical fractures with apertures greater than 4 mm, the slurry may penetrate a substantial distance into the bottom part of the fracture. However, except near the wellbore, the upper part of the fracture will remain open due to gravity segregation. We compared various approaches to plugging fractures using gels, including (1) varying polymer content, (2) varying placement (extrusion) rate, (3) using partially formed gels, (4) using combinations of high and low molecular weight (Mw) polymers, (5) using secondary crosslinking reactions, (6) injecting un-hydrated polymer particles, and (7) incorporating particulates. All of these methods showed promise in some aspects, but required performance improvements in other aspects. All materials investigated to date showed significant performance variations with fracture width. High pressure gradients and limited distance of penetration are common problems in tight fractures. Gravity segregation and low resistance to breaching are common problems in wide fractures. These will be key issues to address in future work. Although gels can exhibit disproportionate permeability reduction in fractures, the levels of permeability reduction for oil flow are too high to allow practical exploitation in most circumstances. In contrast, disproportionate permeability reduction provided by gels that form in porous rock (adjacent to the fractures) has considerable potential in fractured systems.

Randall S. Seright

2004-09-30T23:59:59.000Z

262

Differential expression of nanog1 and nanogp8 in colon cancer cells  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Nanog is expressed in a majority of colon cancer cell lines examined. Black-Right-Pointing-Pointer Both nanog1 and nanogp8 are expressed in colon cancer cells with varying ratios. Black-Right-Pointing-Pointer Nanog mediates cell proliferation of colon cancer cells. Black-Right-Pointing-Pointer Nanog predominantly localizes in cytoplasm of colon cancer cells. -- Abstract: Nanog, a homeodomain transcription factor, is an essential regulator for promotion of self-renewal of embryonic stem cells and inhibition of their differentiation. It has been demonstrated that nanog1 as well as nanogp8, a retrogene of nanog1, is preferentially expressed in advanced stages of several types of cancer, suggesting their involvement during cancer progression. Here, we investigated the expression of Nanog in well-characterized colon cancer cell lines. Expression of Nanog was detectable in 5 (HCT116, HT29, RKO, SW48, SW620) out of seven cell lines examined. RNA expression analyses of nanog1 and nanogp8 indicated that, while nanog1 was a major form in SW620 as well as in teratoma cells Tera-2, nanogp8 was preferentially expressed in HT29 and HCT116. In accordance with this, shRNA-mediated knockdown of nanog1 caused the reduction of Nanog in SW620 but not in HT29. Inhibition of Nanog in SW620 cells negatively affected cell proliferation and tumor formation in mouse xenograft. Biochemical subcellular fractionation and immunostaining analyses revealed predominant localization of Nanog in cytoplasm in SW620 and HT29, while it was mainly localized in nucleus in Tera-2. Our data indicate that nanog1 and nanogp8 are differentially expressed in colon cancer cells, and suggest that their expression contributes to proliferation of colon cancer cells.

Ishiguro, Tatsuya; Sato, Ai; Ohata, Hirokazu; Sakai, Hiroaki [Division of Cancer Differentiation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Cancer Differentiation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Nakagama, Hitoshi, E-mail: hnakagam@ncc.go.jp [Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Okamoto, Koji, E-mail: kojokamo@ncc.go.jo [Division of Cancer Differentiation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Cancer Differentiation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)

2012-02-10T23:59:59.000Z

263

Targeted cancer therapies can modu-late host immune responses, which  

E-Print Network [OSTI]

-incubation of ERBB2-expressing breast cancer cell lines and purified human NK cells with trastuzumab upregulated CD-1BB) in NK cells could improve trastuzumab efficacy. In vitro studies showed that co137 on the NK cells. These activated NK cells were able to kill trastuzumab-coated ERBB2-expressing

Cai, Long

264

USHER: Improving Data Quality with Dynamic Forms  

E-Print Network [OSTI]

Abstract Data quality is a critical problem in modern databases. Data entry forms present the first and arguably best opportunity for detecting and mitigating errors, but there has been little research into automatic methods for improving data quality at entry time. In this paper, we propose USHER, an endto-end system for form design, entry, and data quality assurance. Using previous form submissions, USHER learns a probabilistic model over the questions of the form. USHER then applies this model at every step of the data entry process to improve data quality. Before entry, it induces a form layout that captures the most important data values of a form instance as quickly as possible. During entry, it dynamically adapts the form to the values being entered, and enables real-time feedback to guide the data enterer toward their intended values. After entry, it re-asks questions that it deems likely to have been entered incorrectly. We evaluate all three components of USHER using two real-world data sets. Our results demonstrate that each component has the potential to improve data quality considerably, at a reduced cost when compared to current practice. I.

Kuang Chen; Harr Chen; Neil Conway; Joseph M. Hellerstein; Tapan S. Parikh

265

An analytics approach to designing clinical trials for cancer  

E-Print Network [OSTI]

Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer ...

Relyea, Stephen L. (Stephen Lawrence)

2013-01-01T23:59:59.000Z

266

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network [OSTI]

and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

267

The effect of gender on Helicobacter pylori and gastric cancer  

E-Print Network [OSTI]

Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

Sheh, Alexander

2011-01-01T23:59:59.000Z

268

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This report describes work performed during the second year of the project, ''Conformance Improvement Using Gels.'' The project has two objectives. The first objective is to identify gel compositions and conditions that substantially reduce flow through fractures that allow direct channeling between wells, while leaving secondary fractures open so that high fluid injection and production rates can be maintained. The second objective is to optimize treatments in fractured production wells, where the gel must reduce permeability to water much more than that to oil. Pore-level images from X-ray computed microtomography were re-examined for Berea sandstone and porous polyethylene. This analysis suggests that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than a gel-ripping mechanism. This finding helps to explain why aqueous gels can reduce permeability to water more than to oil. We analyzed a Cr(III)-acetate-HPAM gel treatment in a production well in the Arbuckle formation. The availability of accurate pressure data before, during, and after the treatment was critical for the analysis. After the gel treatment, water productivity was fairly constant at about 20% of the pre-treatment value. However, oil productivity was stimulated by a factor of 18 immediately after the treatment. During the six months after the treatment, oil productivity gradually decreased to approach the pre-treatment value. To explain this behavior, we proposed that the fracture area open to oil flow was increased substantially by the gel treatment, followed by a gradual closing of the fractures during subsequent production. For a conventional Cr(III)-acetate-HPAM gel, the delay between gelant preparation and injection into a fracture impacts the placement, leakoff, and permeability reduction behavior. Formulations placed as partially formed gels showed relatively low pressure gradients during placement, and yet substantially reduced the flow capacity of fractures (with widths from 1 to 4 mm) during brine and oil flow after placement. Regardless of gel age before placement, very little gel washed out from the fractures during brine or oil flow. However, increased brine or oil flow rate and cyclic injection of oil and water significantly decreased the level of permeability reduction. A particular need exists for gels that can plug large apertures (e.g., wide fractures and vugs). Improved mechanical strength and stability were demonstrated (in 1- to 4-mm-wide fractures) for a gel that contained a combination of high- and low-molecular weight polymers. This gel reduced the flow capacity of 2- and 4-mm-wide fractures by 260,000. In a 1-mm-wide fracture, it withstood 26 psi/ft without allowing any brine flow through the fracture. Cr(III)-acetate-HPAM gels exhibited disproportionate permeability reduction in fractures. The effect was most pronounced when the gel was placed as gelant or partially formed gels. The effect occurred to a modest extent with concentrated gels and with gels that were ''fully formed'' when placed. The effect was not evident in tubes. We explored swelling polymers for plugging fractures. Polymer suspensions were quickly prepared and injected. In concept, the partially dissolved polymer would lodge and swell to plug the fracture. For three types of swelling polymers, behavior was promising. However, additional development is needed before their performance will be superior to that of conventional gels.

Randall S. Seright

2003-09-01T23:59:59.000Z

269

Molecular Markers of Lung Cancer in MAYAK Workers  

SciTech Connect (OSTI)

The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC from workers and controls to identify genes targeted for inactivation by plutonium in this other common histologic form of lung cancer. We will examine methylation of the p16, O{sup 6}-methylguanine-DNA methyl-transferase (MGMT), and death associated protein kinase genes ([DAP-K], evaluated previously in adenocarcinomas) as well as the new genes being assessed in the adenocarcinomas. The second hypothesis will be tested in a cross-sectional study of cancer-free workers exposed to plutonium and an unexposed population. A cohort of 700 cancer-free workers and 700 unexposed persons is being assembled, exposures are being defined, and induced sputum collected at initial entry into the study and approximately 1-year later. Exposed and unexposed persons will be matched by 5-year age intervals and smoking status (current and former). The frequency for methylation of four genes that show the greatest difference in prevalence in tumors from workers and controls will be determined in exfoliated cells within sputum. These studies will extend those in primary tumors to determine whether difference in prevalence for individual or multiple genes are detected in sputum samples from high-risk subjects exposed to plutonium. Follow-up of this cohort offers the opportunity to validate these endpoints and future biomarkers as true markers for lung cancer risk.

Steven A. Belinsky, PhD

2007-02-15T23:59:59.000Z

270

Gamma Knife Radiosurgery for Brain Metastases From Primary Breast Cancer  

SciTech Connect (OSTI)

Purpose: The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from breast cancer remain undefined. In this study, we reviewed our experience with these patients. Materials and Methods: We retrospectively reviewed all patients treated between 1991 and 2005 with Gamma Knife SRS for brain metastases from breast cancer. The actuarial survival and freedom from progression endpoints were calculated using the Kaplan-Meier method. Results: Between 1991 and 2005, 176 patients underwent SRS for brain metastases from breast cancer. The median survival time was 16.0 months for 95 newly diagnosed patients and 11.7 months for 81 patients with recurrent brain metastases. In the newly diagnosed patients, omission of upfront WBRT did not significantly affect the MST (p = .20), brain freedom from progression (p = .75), or freedom from new brain metastases (p = .83). Longer survival was associated with age <50 years, Karnofsky performance score >=70, primary tumor control, estrogen receptor positivity, and Her2/neu overexpression. No association was found between the number of treated brain metastases and the survival time. Conclusion: We have described prognostic factors for breast cancer patients treated with SRS for newly diagnosed or recurrent brain metastases. Most patient subsets had a median survival time of >=11 months. Unexpectedly, upfront WBRT did not appear to improve brain freedom from progression, and a larger number of brain metastases was not associated with a shorter survival time. Breast cancer might be distinct from other primary sites in terms of prognostic factors and the roles of WBRT and SRS for brain metastases.

Kased, Norbert, E-mail: Norbert.Kased@ucsf.ed [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Binder, Devin K. [Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); McDermott, Michael W. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Nakamura, Jean L.; Huang, Kim [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Berger, Mitchel S. [Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Wara, William M.; Sneed, Penny K. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States)

2009-11-15T23:59:59.000Z

271

Solar neutrino detection  

E-Print Network [OSTI]

More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

Lino Miramonti

2009-01-22T23:59:59.000Z

272

Cell Phone Detection Techniques  

SciTech Connect (OSTI)

A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phones electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.

2007-10-01T23:59:59.000Z

273

Protein detection system  

DOE Patents [OSTI]

The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.

Fruetel, Julie A. (Livermore, CA); Fiechtner, Gregory J. (Bethesda, MD); Kliner, Dahv A. V. (San Ramon, CA); McIlroy, Andrew (Livermore, CA)

2009-05-05T23:59:59.000Z

274

Noninvasive identification of bladder cancer with sub-surface backscattered light  

SciTech Connect (OSTI)

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorption bands in the tissue also add useful complexity to the spectral data collected. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering as well as absorption. The data acquisition and storage/display time with the OBS instrument is {approximately}1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g., as in skin cancer or cervical cancer). We report here specifically on its potential application in the detection of bladder cancer.

Bigio, I.J.; Mourant, J.R.; Boyer, J.; Johnson, T.; Shimada, T. [Los Alamos National Lab., NM (United States); Conn, R.L. [Lovelace Medical Center, Albuquerque, NM (United States). Dept. of Urology

1994-02-01T23:59:59.000Z

275

Aspects of leak detection  

SciTech Connect (OSTI)

A requirement of a Leak before Break safety case is that the leakage from the through wall crack be detected prior to any growth leading to unacceptable failure. This paper sets out to review some recent developments in this field. It does not set out to be a comprehensive guide to all of the methods available. The discussion concentrates on acoustic emission and how the techniques can be qualified and deployed on operational plant.

Chivers, T.C. [Berkeley Technology Centre, Glos (United Kingdom)

1997-04-01T23:59:59.000Z

276

Detection of pump degradation  

SciTech Connect (OSTI)

This Phase II Nuclear Plant Aging Research study examines the methods of detecting pump degradation that are currently employed in domestic and overseas nuclear facilities. This report evaluates the criteria mandated by required pump testing at U.S. nuclear power plants and compares them to those features characteristic of state-of-the-art diagnostic programs and practices currently implemented by other major industries. Since the working condition of the pump driver is crucial to pump operability, a brief review of new applications of motor diagnostics is provided that highlights recent developments in this technology. The routine collection and analysis of spectral data is superior to all other technologies in its ability to accurately detect numerous types and causes of pump degradation. Existing ASME Code testing criteria do not require the evaluation of pump vibration spectra but instead overall vibration amplitude. The mechanical information discernible from vibration amplitude analysis is limited, and several cases of pump failure were not detected in their early stages by vibration monitoring. Since spectral analysis can provide a wealth of pertinent information concerning the mechanical condition of rotating machinery, its incorporation into ASME testing criteria could merit a relaxation in the monthly-to-quarterly testing schedules that seek to verify and assure pump operability. Pump drivers are not included in the current battery of testing. Operational problems thought to be caused by pump degradation were found to be the result of motor degradation. Recent advances in nonintrusive monitoring techniques have made motor diagnostics a viable technology for assessing motor operability. Motor current/power analysis can detect rotor bar degradation and ascertain ranges of hydraulically unstable operation for a particular pump and motor set. The concept of using motor current or power fluctuations as an indicator of pump hydraulic load stability is presented.

Greene, R.H.; Casada, D.A.; Ayers, C.W. [and others

1995-08-01T23:59:59.000Z

277

Method for detecting biomolecules  

DOE Patents [OSTI]

A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode

Huo, Qisheng (Albuquerque, NM); Liu, Jun (Albuquerque, NM)

2008-08-12T23:59:59.000Z

278

Biomolecular detection device  

DOE Patents [OSTI]

A device for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode.

Huo, Qisheng (Albuquerque, NM); Liu, Jun (Albuquerque, NM)

2008-10-21T23:59:59.000Z

279

Clinical Cancer Care Full screening services and diagnostics  

E-Print Network [OSTI]

Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

Myers, Lawrence C.

280

CONFORMANCE IMPROVEMENT USING GELS  

SciTech Connect (OSTI)

This technical progress report describes work performed from September 1, 2003, through February 29, 2004, for the project, ''Conformance Improvement Using Gels.'' We examined the properties of several ''partially formed'' gels that were formulated with a combination of high and low molecular weight HPAM polymers. After placement in 4-mm-wide fractures, these gels required about 25 psi/ft for brine to breach the gel (the best performance to date in fractures this wide). After this breach, stabilized residual resistance factors decreased significantly with increased flow rate. Also, residual resistance factors were up to 9 times greater for water than for oil. Nevertheless, permeability reduction factors were substantial for both water and oil flow. Gel with 2.5% chopped fiberglass effectively plugged 4-mm-wide fractures if a 0.5-mm-wide constriction was present. The ability to screen-out at a constriction appears crucial for particulate incorporation to be useful in plugging fractures. In addition to fiberglass, we examined incorporation of polypropylene fibers into gels. Once dispersed in brine or gelant, the polypropylene fibers exhibited the least gravity segregation of any particulate that we have tested to date. In fractures with widths of at least 2 mm, 24-hr-old gels (0.5% high molecular weight HPAM) with 0.5% fiber did not exhibit progressive plugging during placement and showed extrusion pressure gradients similar to those of gels without the fiber. The presence of the fiber roughly doubled the gel's resistance to first breach by brine flow. The breaching pressure gradients were not as large as for gels made with high and low molecular weight polymers (mentioned above). However, their material requirements and costs (i.e., polymer and/or particulate concentrations) were substantially lower than for those gels. A partially formed gel made with 0.5% HPAM did not enter a 0.052-mm-wide fracture when applying a pressure gradient of 65 psi/ft. This result suggests a lower limit of fracture width for entry of formed or partially formed gels (when reasonable pressure gradients are applied). In unfractured porous rock, we investigated the time dependence of oil and water permeabilities during various cycles of oil and water injection after placement of a Cr(III)-acetate-HPAM gel. Permeability to water stabilized rapidly (within 1 pore volume, PV), while permeability to oil stabilized gradually over the course of 100 PV. The behavior was surprisingly insensitive to core material (strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene), core permeability (740 to 10,000 md), and applied pressure gradient (10 to 100 psi/ft).

Randall S. Seright

2004-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Seminars in Cancer Biology 15 (2005) 484493 Dynamics of colorectal cancer  

E-Print Network [OSTI]

Seminars in Cancer Biology 15 (2005) 484­493 Review Dynamics of colorectal cancer Franziska Michora Abstract Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main

Nowak, Martin A.

282

Do cancer cells undergo phenotypic switching? The case for imperfect cancer  

E-Print Network [OSTI]

Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers Celoria 26, 20133 Milano, Italy. The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations

De Cindio, Fiorella

283

Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer  

E-Print Network [OSTI]

Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

Greenaway, Alan

284

Cancer Epidemiol Biomarkers Prev. Author manuscript Diet, cancer, and the lipidome  

E-Print Network [OSTI]

Cancer Epidemiol Biomarkers Prev. Author manuscript Page /1 8 Diet, cancer, and the lipidome Bougnoux Philippe 1 * , Giraudeau Bruno 2 , Couet Charles 1 Nutrition, Croissance et Cancer1 INSERM : E211 with the development of breast cancer by delaying its occurrence makes identification of defined molecules a mandatory

Paris-Sud XI, Université de

285

NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 HCIP class.  

E-Print Network [OSTI]

NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 by March 1st. Apply online! See website for further details. http://hcip.nci.nih.gov The National Cancer (NIH), is the Federal Government's principal agency for cancer research and training. The NCI

Cinabro, David

286

Mabs against Pancreatic cancer Therapeutic antibodies for the treatment of pancreatic cancer  

E-Print Network [OSTI]

Mabs against Pancreatic cancer 1 Therapeutic antibodies for the treatment of pancreatic cancer pancreatic cancer inserm-00497886,version1-6Jul2010 Author manuscript, published in "TheScientificWorldJournal (electronic resource) 2010;10:1107-20" DOI : 10.1100/tsw.2010.103 #12;Mabs against Pancreatic cancer 2

Paris-Sud XI, Université de

287

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens  

E-Print Network [OSTI]

Finding links to cancer Masonic Cancer Center researchers work to identify carcinogens in the world around us--as well as ways to avoid them When scientists talk about "environmental" causes of cancer are linked to as many as two out of every three cancers diagnosed. DeAnn Lazovich, Ph.D., M.P.H., is one

Minnesota, University of

288

Automated assessment of bilateral breast volume asymmetry as a breast cancer biomarker during mammographic screening  

SciTech Connect (OSTI)

The biological concept of bilateral symmetry as a marker of developmental stability and good health is well established. Although most individuals deviate slightly from perfect symmetry, humans are essentially considered bilaterally symmetrical. Consequently, increased fluctuating asymmetry of paired structures could be an indicator of disease. There are several published studies linking bilateral breast size asymmetry with increased breast cancer risk. These studies were based on radiologists manual measurements of breast size from mammographic images. We aim to develop a computerized technique to assess fluctuating breast volume asymmetry in screening mammograms and investigate whether it correlates with the presence of breast cancer. Using a large database of screening mammograms with known ground truth we applied automated breast region segmentation and automated breast size measurements in CC and MLO views using three well established methods. All three methods confirmed that indeed patients with breast cancer have statistically significantly higher fluctuating asymmetry of their breast volumes. However, statistically significant difference between patients with cancer and benign lesions was observed only for the MLO views. The study suggests that automated assessment of global bilateral asymmetry could serve as a breast cancer risk biomarker for women undergoing mammographic screening. Such biomarker could be used to alert radiologists or computer-assisted detection (CAD) systems to exercise increased vigilance if higher than normal cancer risk is suspected.

Williams, Alex C [ORNL; Hitt, Austin N [ORNL; Voisin, Sophie [ORNL; Tourassi, Georgia [ORNL

2013-01-01T23:59:59.000Z

289

Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study  

SciTech Connect (OSTI)

Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

Boukheris, Houda [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel S. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stratton, Kayla L. [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States)] [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States); Smith, Susan A.; Weathers, Rita [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hammond, Sue [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States)] [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States); Mertens, Ann C. [Department of Pediatrics, Emory University, Atlanta, Georgia (United States)] [Department of Pediatrics, Emory University, Atlanta, Georgia (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)] [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States); Armstrong, Gregory T.; Robison, Leslie L. [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States)] [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Neglia, Joseph P. [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States)] [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Inskip, Peter D., E-mail: inskippe@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-03-01T23:59:59.000Z

290

STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH{sup +}/CD133{sup +} stem cell-like human colon cancer cells  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer The phosphorylated or activated form of STAT3 was expressed in colon cancer stem-like cells. Black-Right-Pointing-Pointer STAT3 inhibitor, FLLL32 inhibits P-STAT3 and STAT3 target genes in colon cancer stem-like cells. Black-Right-Pointing-Pointer Inhibition of STAT3 resulted in decreased cell viability and reduced numbers of tumorspheres. Black-Right-Pointing-Pointer STAT3 is required for survival and tumorsphere forming capacity in colon cancer stem-like cells. Black-Right-Pointing-Pointer Targeting STAT3 in cancer stem-like cells may offer a novel treatment approach for colon cancer. -- Abstract: Persistent activation of Signal Transducers and Activators of Transcription 3 (STAT3) is frequently detected in colon cancer. Increasing evidence suggests the existence of a small population of colon cancer stem or cancer-initiating cells may be responsible for tumor initiation, metastasis, and resistance to chemotherapy and radiation. Whether STAT3 plays a role in colon cancer-initiating cells and the effect of STAT3 inhibition is still unknown. Flow cytometry was used to isolate colon cancer stem-like cells from three independent human colon cancer cell lines characterized by both aldehyde dehydrogenase (ALDH)-positive and CD133-positive subpopulation (ALDH{sup +}/CD133{sup +}). The effects of STAT3 inhibition in colon cancer stem-like cells were examined. The phosphorylated or activated form of STAT3 was expressed in colon cancer stem-like cells and was reduced by a STAT3-selective small molecular inhibitor, FLLL32. FLLL32 also inhibited the expression of potential STAT3 downstream target genes in colon cancer stem-like cells including survivin, Bcl-XL, as well as Notch-1, -3, and -4, which may be involved in stem cell function. Furthermore, FLLL32 inhibited cell viability and tumorsphere formation as well as induced cleaved caspase-3 in colon cancer stem-like cells. FLLL32 is more potent than curcumin as evidenced with lower IC50 in colon cancer stem-like cells. In summary, our results indicate that STAT3 is a novel therapeutic target in colon cancer stem-like cells and inhibition of STAT3 in cancer stem-like cells may offer a potential treatment for colorectal cancer.

Lin, Li, E-mail: lin.796@osu.edu [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States) [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States); Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 (China); Fuchs, James; Li, Chenglong [Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States)] [Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States); Olson, Veronica [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States)] [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States); Bekaii-Saab, Tanios [Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210 (United States)] [Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210 (United States); Lin, Jiayuh, E-mail: lin.674@osu.edu [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States)] [Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205 (United States)

2011-12-16T23:59:59.000Z

291

Cancer Vulnerabilities Unveiled by Genomic Loss  

E-Print Network [OSTI]

Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...

Nijhawan, Deepak

292

Targeting cancer metabolism: a therapeutic window opens  

E-Print Network [OSTI]

Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

Vander Heiden, Matthew G.

293

Remote detection of fissile material : Cherenkov counters for gamma detection  

E-Print Network [OSTI]

The need for large-size detectors for long-range active interrogation (Al) detection has generated interest in water-based detector technologies. AI is done using external radiation sources to induce fission and to detect, ...

Erickson, Anna S

2011-01-01T23:59:59.000Z

294

Revolution in nuclear detection affairs  

SciTech Connect (OSTI)

The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

Stern, Warren M. [Nonproliferation and National Security Department, Brookhaven National Laboratory, Upton, New York (United States)

2014-05-09T23:59:59.000Z

295

THESIS FOR THE DEGREE OF LICENTIATE OF PHILOSOPHY Improving methods for  

E-Print Network [OSTI]

THESIS FOR THE DEGREE OF LICENTIATE OF PHILOSOPHY Improving methods for Genome Wide Analysis are involved, the power of detecting new genetic risk variants can be improved by considering several genes, the distribution of other genetic risk variants will depend on if they have the necessary variant or not. In Paper

Patriksson, Michael

296

Improve Your Boiler's Combustion Efficiency  

SciTech Connect (OSTI)

This revised ITP tip sheet on boiler combustion efficiency provides how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

Not Available

2006-01-01T23:59:59.000Z

297

Improving Design with Agents, Improving Agents by Design  

E-Print Network [OSTI]

DCB 1 WPI Improving Design with Agents, or, Improving Agents by Design David C. Brown AI in Design ASSUMPTION ? Assume that the design environment is built using agents. i.e., situated, autonomous, flexible ?'s future design and synthesis environment will be built as a real multi-agent system. In what follows, we

Brown, David C.

298

Cancer Epidemiology Population Health Sciences 750  

E-Print Network [OSTI]

-01/5/11-1 Cancer Epidemiology Population Health Sciences 750 3 credits When: Spring 2011 (1 Audience: This course is intended for students in health-related disciplines interested in cancer etiology. the unequal burden of cancer among populations and variations across time and geography, 2. the distinctive

Sheridan, Jennifer

299

Identifying Risk Groups Associated with Colorectal Cancer  

E-Print Network [OSTI]

Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

Jin, Huidong "Warren"

300

Eligibility: Cancer Survivor ages 35-75  

E-Print Network [OSTI]

Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

Walter, Peter

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Blood vessel detection in retinal images and its application in diabetic retinopathy screening  

E-Print Network [OSTI]

transform (RCT) algorithm, which converts the intensity information in spatial domain to a high dimensional radial contrast domain. Different feature descriptors are designed to improve the speed, sensitivity, and expandability of the vessel detection system...

Zhang, Ming

2009-05-15T23:59:59.000Z

302

Using Friends as Sensors to Detect Global-Scale Contagious Outbreaks  

E-Print Network [OSTI]

Recent research has focused on the monitoring of globalscale online data for improved detection of epidemics, mood patterns, movements in the stock market political revolutions, box-office revenues, consumer behaviour and ...

Garcia-Herranz, Manuel

303

The Highest Energy Emission Detected by EGRET from Blazars  

E-Print Network [OSTI]

Published EGRET spectra from blazars extend only to 10 GeV, yet EGRET has detected approximately 2000 gamma-rays above 10 GeV of which about half are at high Galactic latitude. We report a search of these high-energy gamma-rays for associations with the EGRET and TeV detected blazars. Because the point spread function of EGRET improves with energy, only ~2 gamma-rays are expected to be positionally coincident with the 80 blazars searched, yet 23 gamma-rays were observed. This collection of > 10 GeV sources should be of particular interest due to the improved sensitivity and lower energy thresholds of ground-based TeV observatories. One of the blazars, RGB0509+056, has the highest energy gamma-rays detected by EGRET from any blazar with 2 > 40 GeV, and is a BL Lac type blazar with unknown redshift.

Dingus, B L; Dingus, Brenda L.; Bertsch, David L.

2001-01-01T23:59:59.000Z

304

The Highest Energy Emission Detected by EGRET from Blazars  

E-Print Network [OSTI]

Published EGRET spectra from blazars extend only to 10 GeV, yet EGRET has detected approximately 2000 gamma-rays above 10 GeV of which about half are at high Galactic latitude. We report a search of these high-energy gamma-rays for associations with the EGRET and TeV detected blazars. Because the point spread function of EGRET improves with energy, only ~2 gamma-rays are expected to be positionally coincident with the 80 blazars searched, yet 23 gamma-rays were observed. This collection of > 10 GeV sources should be of particular interest due to the improved sensitivity and lower energy thresholds of ground-based TeV observatories. One of the blazars, RGB0509+056, has the highest energy gamma-rays detected by EGRET from any blazar with 2 > 40 GeV, and is a BL Lac type blazar with unknown redshift.

Brenda L. Dingus; David L. Bertsch

2001-07-03T23:59:59.000Z

305

Nucleic acid detection compositions  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Madison, WI); Lyamichev, Victor I. (Madison, WI); Brow, Mary Ann (Madison, WI); Dahlberg, James L. (Madison, WI)

2008-08-05T23:59:59.000Z

306

Opaque cloud detection  

DOE Patents [OSTI]

A method of detecting clouds in a digital image comprising, for an area of the digital image, determining a reflectance value in at least three discrete electromagnetic spectrum bands, computing a first ratio of one reflectance value minus another reflectance value and the same two values added together, computing a second ratio of one reflectance value and another reflectance value, choosing one of the reflectance values, and concluding that an opaque cloud exists in the area if the results of each of the two computing steps and the choosing step fall within three corresponding predetermined ranges.

Roskovensky, John K. (Albuquerque, NM)

2009-01-20T23:59:59.000Z

307

Electrical leakage detection circuit  

DOE Patents [OSTI]

A method is provided for detecting electrical leakage between a power supply and a frame of a vehicle or machine. The disclosed method includes coupling a first capacitor between a frame and a first terminal of a power supply for a predetermined period of time. The current flowing between the frame and the first capacitor is limited to a predetermined current limit. It is determined whether the voltage across the first capacitor exceeds a threshold voltage. A first output signal is provided when the voltage across the capacitor exceeds the threshold voltage.

Wild, Arthur

2006-09-05T23:59:59.000Z

308

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version  

E-Print Network [OSTI]

European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

Boyer, Edmond

309

Improved Radiation Dosimetry/Risk Estimates to Facilitate Environmental Management of Plutonium-Contaminated Sites  

SciTech Connect (OSTI)

This report summarizes 4 years of research achievements in this Office of Science (BER), U.S. Department of Energy (DOE) project. The research described was conducted by scientists and supporting staff at Lovelace Respiratory Research Institute (LRRI)/Lovelace Biomedical and Environmental Research Institute (LBERI) and the Southern Urals Biophysics Institute (SUBI). All project objectives and goals were achieved. A major focus was on obtaining improved cancer risk estimates for exposure via inhalation to plutonium (Pu) isotopes in the workplace (DOE radiation workers) and environment (public exposures to Pu-contaminated soil). A major finding was that low doses and dose rates of gamma rays can significantly suppress cancer induction by alpha radiation from inhaled Pu isotopes. The suppression relates to stimulation of the body's natural defenses, including immunity against cancer cells and selective apoptosis which removes precancerous and other aberrant cells.

Scott, Bobby R.; Tokarskaya, Zoya B.; Zhuntova, Galina V.; Osovets, Sergey V.; Syrchikov, Victor A., Belyaeva, Zinaida D.

2007-12-14T23:59:59.000Z

310

SYN T H E S I STHE magazinE OF UC DAVIS CANCER CENTER VOL 14 nO 1 SPRing/SUmmER 2011 making their mark against  

E-Print Network [OSTI]

data in the country. Our story on this collaboration describes some of the efforts already under way to use this data to better understand cancer and improve care and outcomes for patients. Finally disparities among American Indians, two cancer powerhouses team up, and more S Y N T H E S I S THE magazin

Leistikow, Bruce N.

311

Design of proximity detecting codes  

E-Print Network [OSTI]

class of codes called Proximity Detecting Codes can be used to overcome this problem associated with asynchronous channels. A t-proximity detecting (t-PD) code can detect when a received word is within distance t from the transmitted codeword, when using...

Perisetty, Srinivas

1997-01-01T23:59:59.000Z

312

DCA for Bot Detection  

E-Print Network [OSTI]

Ensuring the security of computers is a non-trivial task, with many techniques used by malicious users to compromise these systems. In recent years a new threat has emerged in the form of networks of hijacked zombie machines used to perform complex distributed attacks such as denial of service and to obtain sensitive data such as password information. These zombie machines are said to be infected with a 'bot' - a malicious piece of software which is installed on a host machine and is controlled by a remote attacker, termed the 'botmaster of a botnet'. In this work, we use the biologically inspired Dendritic Cell Algorithm (DCA) to detect the existence of a single bot on a compromised host machine. The DCA is an immune-inspired algorithm based on an abstract model of the behaviour of the dendritic cells of the human body. The basis of anomaly detection performed by the DCA is facilitated using the correlation of behavioural attributes such as keylogging and packet flooding behaviour. The results of the applica...

Al-Hammadi, Yousof; Greensmith, Julie

2010-01-01T23:59:59.000Z

313

MULTIMOMENT RADIO TRANSIENT DETECTION  

SciTech Connect (OSTI)

We present a multimoment technique for signal classification and apply it to the detection of fast radio transients in incoherently dedispersed data. Specifically, we define a spectral modulation index in terms of the fractional variation in intensity across a spectrum. A signal whose intensity is distributed evenly across the entire band has a lower modulation index than a spectrum whose intensity is localized in a single channel. We are interested in broadband pulses and use the modulation index to excise narrowband radio frequency interference by applying a modulation index threshold above which candidate events are removed. The technique is tested both with simulations and using data from known sources of radio pulses (RRAT J1928+15 and giant pulses from the Crab pulsar). The method is generalized to coherent dedispersion, image cubes, and astrophysical narrowband signals that are steady in time. We suggest that the modulation index, along with other statistics using higher order moments, should be incorporated into signal detection pipelines to characterize and classify signals.

Spitler, L. G.; Cordes, J. M.; Chatterjee, S. [Astronomy Department and NAIC, Cornell University, Ithaca, NY 14853 (United States); Stone, J., E-mail: lspitler@astro.cornell.edu [Department of Physics and Astronomy, Barnard College, New York, NY 10027 (United States)

2012-04-01T23:59:59.000Z

314

Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial  

E-Print Network [OSTI]

cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

2010-01-01T23:59:59.000Z

315

Digital Tomosynthesis: Advanced Breast Cancer  

E-Print Network [OSTI]

creating an image. · A newer process, called full field digital mammography uses digital receptors. #12Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital Bremsstrahlung, a process in which electrons are accelerated against an anode, causing photons to be fired off

Fygenson, Deborah Kuchnir

316

Do Cell Phones Cause Cancer?  

E-Print Network [OSTI]

Do cell phones, household electrical power wiring or appliance, or high voltage power lines cause cancer? Fuggedaboudit! No way! When pigs fly! When I'm the Pope! Don't text while you're driving, however, or eat your cell phone. All organisms absorb microwave radiation directly as thermal energy. In living organisms, the organisms' thermal control systems, including the blood flow, and various cooling mechanisms, such as sweating in humans, that work to maintain a stable body temperature rapidly transfer the absorbed energy to the environment. Any temperature rise is small or even unobserved. Any proposed mechanism by which cell phone radiation might cause cancer must begin with this fact. But the amount of radiation absorbed from a cell phone is less than that produced by normal metabolic processes, and much less than that produced by, for example, exercise. None of these normal metabolic processes cause cancer. Therefore, the much smaller amounts of energy from cell phones doesn't cause cancer either. All f...

Leikind, Bernard

2010-01-01T23:59:59.000Z

317

Water Efficiency Improvements at Various Environmental Protection...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Water Efficiency Improvements at Various Environmental Protection Agency Sites Water Efficiency Improvements at Various Environmental Protection Agency Sites Water Efficiency...

318

Improving alternative fuel utilization: detailed kinetic combustion...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Improving alternative fuel utilization: detailed kinetic combustion modeling & experimental testing Improving alternative fuel utilization: detailed kinetic combustion modeling &...

319

A Mobility and Energy-aware Hierarchical Intrusion Detection System for Mobile ad hoc Networks  

E-Print Network [OSTI]

A Mobility and Energy-aware Hierarchical Intrusion Detection System for Mobile ad hoc Networks consumption. The proposed architecture adopts and enhances the Mobility and Energy Aware Clustering Algorithm and energy of nodes in the cluster formation in order to improve detection accuracy and re- duce energy

Stavrakakis, Ioannis

320

Remote NMR/MRI detection of laser polarized gases  

DOE Patents [OSTI]

An apparatus and method for remote NMR/MRI spectroscopy having an encoding coil with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps. This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb--Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.

Pines, Alexander; Saxena, Sunil; Moule, Adam; Spence, Megan; Seeley, Juliette A.; Pierce, Kimberly L.; Han, Song-I; Granwehr, Josef

2006-06-13T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study  

SciTech Connect (OSTI)

Purpose: We have previously shown that the addition of cetuximab to chemoradiation therapy failed to improve complete response rates (pCR) in rectal cancer. Here we report the long-term results of the cetuximab added to preoperative radiation therapy with capecitabine and oxaliplatin (CET-CAPOX-RT) phase 1/2 study that evaluated preoperative chemoradiation with cetuximab, capecitabine, and oxaliplatin in patients with rectal cancer. Methods and Materials: The median follow-up was 63 months (range, 5-73 months). Sixty patients were enrolled; 3 patients were excluded due to protocol violation, and 4 died before surgery. Total mesorectal excision was performed in 53 patients, in 85% (n=45) with curative intention (M0-status). Secondary end points including overall survival (OS) disease-free survival (DFS) and cancer-specific survival (CSS) were calculated. The prognostic value of KRAS mutation status was also assessed. Results: Histopathological examination confirmed ypUICC stages 0 (n=4; pCR), I (n=17), II (n=10), III (n=14), and IV (n=8). For patients who underwent surgery (n=53), OS at 1, 3, and 5 years was 88.7%, 83%, and 75.5%, respectively, whereas CSS rates were 94.1%, 88.1%, and 78.1%, respectively. In the 45 patients who were treated with curative intent (M0), the OS rates at 1, 3, and 5 years were 91.1%, 88.9%, and 86.7%, respectively; whereas CSS rates were 97.6%, 95.2%, and 90.3%, respectively; and DFS rates were 90.7%, 88.3%, and 88.3%, respectively. We did not find any locoregional failure in patients with M0-status (n=45). Chronic toxicity was rare. KRAS mutations, as detected in 33.3%, showed no correlation with the clinicopathological parameters nor significance for either OS (P=.112), CSS (P=.264), or DFS (P=.565). Conclusions: Taken together, chemoradiation therapy combined with cetuximab is safe, feasible, and offers excellent survival rates. KRAS mutation status was not a predictive factor. Importantly, lack of improvement in pCR rate did not translate to poor survival in our clinical trial.

Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Conradi, Lena [Department of General Surgery, University Medical Center of Gttingen (Germany); Weiss, Christian [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Sprenger, Thilo [Department of General Surgery, University Medical Center of Gttingen (Germany); Middel, Peter [Institute for Pathology, University Medical Center, Gttingen (Germany); Rau, Tillman [Institute of Pathology, University Hospital Erlangen, Erlangen (Germany); Dellas, Kathrin [Department of Radiotherapy, Lbeck University (Germany); Kitz, Julia [Institute for Pathology, University Medical Center, Gttingen (Germany); Rdel, Franz [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Sauer, Rolf [Department of Radiation Oncology, University of Erlangen (Germany); Rschoff, Josef [Targos Molecular Pathology, Kassel (Germany); Beissbarth, Tim [Department of Medical Statistics, University Medical Center of Gttingen (Germany); Arnold, Dirk [Tumor Biology Center Freiburg, University of Freiburg (Germany); Ghadimi, B. Michael [Department of General Surgery, University Medical Center of Gttingen (Germany); Rdel, Claus [Department of Radiation Therapy and Oncology, University of Frankfurt (Germany); Liersch, Torsten [Department of General Surgery, University Medical Center of Gttingen (Germany)

2013-12-01T23:59:59.000Z

322

Detection of gas leakage  

DOE Patents [OSTI]

A method of detecting leaks and measuring volumes as well as an apparatus, the Power-free Pump Module (PPM), that is a self-contained leak test and volume measurement apparatus that requires no external sources of electrical power during leak testing or volume measurement, where the invention is a portable, pneumatically-controlled instrument capable of generating a vacuum, calibrating volumes, and performing quantitative leak tests on a closed test system or device, all without the use of alternating current (AC) power. Capabilities include the ability is to provide a modest vacuum (less than 10 Torr), perform a pressure rise leak test, measure the gas's absolute pressure, and perform volume measurements. All operations are performed through a simple rotary control valve which controls pneumatically-operated manifold valves.

Thornberg, Steven (Peralta, NM); Brown, Jason (Albuquerque, NM)

2012-06-19T23:59:59.000Z

323

Arc fault detection system  

DOE Patents [OSTI]

An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard.

Jha, Kamal N. (Bethel Park, PA)

1999-01-01T23:59:59.000Z

324

Arc fault detection system  

DOE Patents [OSTI]

An arc fault detection system for use on ungrounded or high-resistance-grounded power distribution systems is provided which can be retrofitted outside electrical switchboard circuits having limited space constraints. The system includes a differential current relay that senses a current differential between current flowing from secondary windings located in a current transformer coupled to a power supply side of a switchboard, and a total current induced in secondary windings coupled to a load side of the switchboard. When such a current differential is experienced, a current travels through a operating coil of the differential current relay, which in turn opens an upstream circuit breaker located between the switchboard and a power supply to remove the supply of power to the switchboard. 1 fig.

Jha, K.N.

1999-05-18T23:59:59.000Z

325

Hamilton County- Home Improvement Program  

Broader source: Energy.gov [DOE]

The Hamilton County, Ohio, Home Improvement Program (HIP) was originally initiated in 2002, and then reinstated in May 2008. The HIP loan allows homeowners in Hamilton County communities to borrow...

326

Understanding and Improving Software Productivity  

E-Print Network [OSTI]

Understanding and Improving Software Productivity Walt Scacchi Institute for Software Research;2 Introduction What affects software productivity? Software productivity has been one of the most studied aspects of software engineering Goal: review sample of empirical studies of software productivity

Scacchi, Walt

327

Applications of a single-molecule detection in early disease diagnosis and enzymatic reaction study  

SciTech Connect (OSTI)

Various single-molecule techniques were utilized for ultra-sensitive early diagnosis of viral DNA and antigen and basic mechanism study of enzymatic reactions. DNA of human papilloma virus (HPV) served as the screening target in a flow system. Alexa Fluor 532 (AF532) labeled single-stranded DNA probes were hybridized to the target HPV-16 DNA in solution. The individual hybridized molecules were imaged with an intensified charge-coupled device (ICCD) in two ways. In the single-color mode, target molecules were detected via fluorescence from hybridized probes only. This system could detect HPV-16 DNA in the presence of human genomic DNA down to 0.7 copy/cell and had a linear dynamic range of over 6 orders of magnitude. In the dual-color mode, fluorescence resonance energy transfer (FRET) was employed to achieve zero false-positive count. We also showed that DNA extracts from Pap test specimens did not interfere with the system. A surface-based method was used to improve the throughput of the flow system. HPV-16 DNA was hybridized to probes on a glass surface and detected with a total internal reflection fluorescence (TIRF) microscope. In the single-probe mode, the whole genome and target DNA were fluorescently labeled before hybridization, and the detection limit is similar to the flow system. In the dual-probe mode, a second probe was introduced. The linear dynamic range covers 1.44-7000 copies/cell, which is typical of early infection to near-cancer stages. The dual-probe method was tested with a crudely prepared sample. Even with reduced hybridization efficiency caused by the interference of cellular materials, we were still able to differentiate infected cells from healthy cells. Detection and quantification of viral antigen with a novel single-molecule immunosorbent assay (SMISA) was achieved. Antigen from human immunodeficiency virus type 1(HIV-1) was chosen to be the target in this study. The target was sandwiched between a monoclonal capture antibody and a polyclonal detector antibody. The capture antibody was covalently immobilized on modified glass slides. The detector antibody was conjugated with AF532 labeled secondary antibody prior to being used as probe for the antigen. Imaging was performed with a TIRF system. This technique is demonstrated for detecting HIV-1 p24 antigen down to 0.1 pg/mL with a dynamic range of over 4 orders of magnitude. A Langmuir isotherm fit the molecule count dependence on the target concentration. The results also showed that neither sensitivity nor dynamic range was affected by the biological matrix. SMISA is therefore a promising approach for the early diagnosis of virus-induced diseases. Single-molecule enzymatic kinetics and enantioselectivity were monitored in real time by using TIRF microscopy. AF532 labeled poly-L-lysine (PLL) or poly-D-lysine (PDL) was covalently immobilized on a dithiobis (succinimidyl undecanoate) self-assembled monolayer (DSU SAM). Chain shortening due to enzymatic hydrolysis resulted in the reduction of the individual fluorescence intensities. A broad distribution was obtained when 100 single-molecule half-lives were analyzed. However, the detailed hydrolysis process involved also a long-lived component and an induction period that varied significantly among molecules. Charge and steric heterogeneity at the surface are responsible for these features.

Li, Jiangwei

2008-10-15T23:59:59.000Z

328

Insights Into the Effect of Trigonelline in the P53 Pathway  

E-Print Network [OSTI]

Colon cancer is the second leading cause of cancer-related deaths in the United States. Early screening has improved detection of precancerous polyps, however, colon cancer still claims over fifty thousand lives per year. Statistics have shown a...

Justice, Jessica

2013-09-26T23:59:59.000Z

329

Improving energy storage devices | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for planning experimental workImprovingImproving

330

Double-strand DNA-templated formation of copper nanoparticles as fluorescent probe for label free nuclease enzyme detection  

E-Print Network [OSTI]

cleavage activity. Thus, a label-free strategy for sensitive detection of nuclease has been developed B.V. All rights reserved. 1. Introduction As promising substitutes for organic dyes and quantum dots epithelial cervical cancer cells (HeLa cells) using fluorescent gold nanoparticles which emitted a stable

Tan, Weihong

331

Cancer in Ireland 1994-2004: A comprehensive report  

E-Print Network [OSTI]

Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

Müller, Jens-Dominik

332

PrincetonUniversity In-Vitro Studies of Cancer  

E-Print Network [OSTI]

PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

Petta, Jason

333

Laser-ultrasound spectroscopy apparatus and method with detection of shear resonances for measuring anisotropy, thickness, and other properties  

DOE Patents [OSTI]

Apparatus and method for detecting shear resonances includes structure and steps for applying a radiation pulse from a pulsed source of radiation to an object to generate elastic waves therein, optically detecting the elastic waves generated in the object, and analyzing the elastic waves optically detected in the object. These shear resonances, alone or in combination with other information, may be used in the present invention to improve thickness measurement accuracy and to determine geometrical, microstructural, and physical properties of the object. At least one shear resonance in the object is detected with the elastic waves optically detected in the object. Preferably, laser-ultrasound spectroscopy is utilized to detect the shear resonances.

Levesque, Daniel (Terrebonne, CA); Moreau, Andre (St-Bruno-de-Montarville, CA); Dubois, Marc (Montreal, CA); Monchalin, Jean-Pierre (Montreal, CA); Bussiere, Jean (St-Bruno, CA); Lord, Martin (Beloeil, CA); Padioleau, Christian (Montreal, CA)

2000-01-01T23:59:59.000Z

334

Genome Wide Proteomics of ERBB2 and EGFR and Other Oncogenic Pathways in Inflammatory Breast Cancer  

E-Print Network [OSTI]

three breast cancer cell lines (SKBR3, SUM149 and SUM190) with different onco- gene expression levels million mapped reads (RPKM) values for ERBB2 (14.4, 400, and 300 for SUM149, SUM190, and SKBR3, respectively) and for EGFR (60.1, not detected, and 1.4 for the same 3 cell lines). We then used RNA-Seq data

335

Incipient fire detection system  

DOE Patents [OSTI]

A method and apparatus for an incipient fire detection system that receives gaseous samples and measures the light absorption spectrum of the mixture of gases evolving from heated combustibles includes a detector for receiving gaseous samples and subjecting the samples to spectroscopy and determining wavelengths of absorption of the gaseous samples. The wavelengths of absorption of the gaseous samples are compared to predetermined absorption wavelengths. A warning signal is generated whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. The method includes receiving gaseous samples, subjecting the samples to light spectroscopy, determining wavelengths of absorption of the gaseous samples, comparing the wavelengths of absorption of the gaseous samples to predetermined absorption wavelengths and generating a warning signal whenever the wavelengths of absorption of the gaseous samples correspond to the predetermined absorption wavelengths. In an alternate embodiment, the apparatus includes a series of channels fluidically connected to a plurality of remote locations. A pump is connected to the channels for drawing gaseous samples into the channels. A detector is connected to the channels for receiving the drawn gaseous samples and subjecting the samples to spectroscopy. The wavelengths of absorption are determined and compared to predetermined absorption wavelengths is provided. A warning signal is generated whenever the wavelengths correspond.

Brooks, Jr., William K. (Newport News, VA)

1999-01-01T23:59:59.000Z

336

Method for detecting an element  

DOE Patents [OSTI]

A method for detecting an element is disclosed and which includes the steps of providing a gamma-ray spectrum which depicts, at least in part, a test region having boundaries, and which has a small amount of the element to be detected; providing a calculation which detects the small amount of the element to be detected; and providing a moving window and performing the calculation within the moving window, and over a range of possible window boundaries within the test region to determine the location of the optimal test region within the gamma-ray spectrum.

Blackwood, Larry G.; Reber, Edward L.; Rohde, Kenneth W.

2007-02-06T23:59:59.000Z

337

Global modeling of cancer gene expression signa-Cancer leads to permanent changes in cell's physiological state and various  

E-Print Network [OSTI]

Global modeling of cancer gene expression signa- tures Cancer leads to permanent changes in cell cancer types. Less is known about the underlying biological processes, or relationships between different cancer types with respect to these changes. While each specific cancer type has a set of unique

Kaski, Samuel

338

Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1  

E-Print Network [OSTI]

Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Cancer Research UK electronic Grants Management System (e://egms.cancerresearchuk.org #12;Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 2

339

Bayesian methods for discontinuity detection in climate model predictions.  

SciTech Connect (OSTI)

Discontinuity detection is an important component in many fields: Image recognition, Digital signal processing, and Climate change research. Current methods shortcomings are: Restricted to one- or two-dimensional setting, Require uniformly spaced and/or dense input data, and Give deterministic answers without quantifying the uncertainty. Spectral methods for Uncertainty Quantification with global, smooth bases are challenged by discontinuities in model simulation results. Domain decomposition reduces the impact of nonlinearities and discontinuities. However, while gaining more smoothness in each subdomain, the current domain refinement methods require prohibitively many simulations. Therefore, detecting discontinuities up front and refining accordingly provides huge improvement to the current methodologies.

Safta, Cosmin; Debusschere, Bert J.; Najm, Habib N.; Sargsyan, Khachik

2010-06-01T23:59:59.000Z

340

DIESEL et CANCER Dominique Lafon  

E-Print Network [OSTI]

1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicité des émissions des moteurs diesel. C'est un sujet qui a beaucoup préoccupé les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicité des émissions du diesel, un rappel de leur composition est

Boyer, Edmond

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

2005LANDESBIOSCIENCE.DONOTDISTRIBUTE. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; 2005 Landes Bioscience  

E-Print Network [OSTI]

not improved long-term survival after resection. -lapachone is a naturally occurring compound presentRadiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa City, Iowa USA 6Departments of Radiation

Gao, Jinming

342

Genome Science and Personalized Cancer Treatment  

ScienceCinema (OSTI)

August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

Joe Gray

2010-01-08T23:59:59.000Z

343

Cancer evolution: mathematical models and computational inference  

E-Print Network [OSTI]

and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland; E-mail: niko.beerenwinkel@bsse.ethz.ch. Abstract. Cancer is a somatic evolutionary process characterized by the accumulation of mutations, which contribute to tumor growth, clinical... Version dated: October 7, 2014 Cancer evolution Cancer evolution: mathematical models and computational inference Niko Beerenwinkel1,2, Roland F Schwarz3, Moritz Gerstung4, Florian Markowetz5 1Department of Biosystems Science and Engineering, ETH...

Beerenwinkel, Niko; Schwarz, Roland F.; Gerstung, Moritz; Markowetz, Florian

2014-10-07T23:59:59.000Z

344

Improved saturation determination with EPT  

SciTech Connect (OSTI)

The accuracy of formation fluid saturations determined by analysis of well logging results has improved steadily over the years. However, the problem of what values to use for the exponents ''m'' and ''n'' in the saturation equation remains. Laboratory measurements on core samples show that these exponents can vary significantly over short intervals, but assumed average values must be used in actual calculations. These average values may or may not be representative, depending on the formation homogeneity. The EPT (Electromagnetic Propagation Tool) measurement allows the calculation of saturations near the borehole without a knowledge of ''m'' or ''n''. Using the EPT saturation, a method is developed to calculate ''m'' and ''n'' from continuous record logs. These calculated values provide an improved water saturation calculation from the regular resistivity and porosity logs. Several examples are shown to demonstrate the application of the new method. Core analyses, core descriptions, and drill stem test results are included which support these improvements.

Freeman, D.W.; Henry, K.C.

1983-03-01T23:59:59.000Z

345

Radium-223: From Radiochemical Development to Clinical Applications in Targeted Cancer Therapy  

SciTech Connect (OSTI)

The radiochemical properties of radium-223 (223Ra, T1/2 = 11.4 d) render this alpha-emitting radionuclide promising for targeted cancer therapy. Together with its short-lived daughters, each 223Ra decay produces four alpha-particle emissionswhich enhance therapy effectiveness at the cellular level. In this paper, we review the recently published data reported for pre-clinical and clinical use of 223Ra in cancer treatment. We have evaluated two distinct chemical forms of 223Ra in vivo: 1) cationic 223Ra as dissolved RaCl2, and 2) liposome-encapsulated 223Ra. Cationic 223Ra seeks metabolically active osteoblastic bone and tumor lesions with high uptake and strong binding affinity based on its similarities to calcium. Based on these properties, we have advanced the clinical use of 223Ra for treating bone metastases from late-stage breast and prostate cancer. The results show impressive anti-tumor activity and improved overall survival in hormone-refractory prostate cancer patients with bone metastases. In other studies, we have evaluated the biodistribution and tumor uptake of liposomally encapsulated 223Ra in mice with human osteosarcoma xenografts, and in dogs with spontaneous osteosarcoma and associated soft tissue metastases. Results indicate excellent biodistributions in both species. In dogs, we found considerable uptake of liposomal 223Ra in cancer metastases in multiple organs, resulting in favorable tumor-to-normal soft tissue ratios. Collectively, these findings show an outstanding potential for 223Ra as a therapeutic agent.

Bruland, Oyvind S.; Jonasdottir, Thora J.; Fisher, Darrell R.; Larsen, Roy H.

2008-09-15T23:59:59.000Z

346

Real-time system for imaging and object detection with a multistatic GPR array  

DOE Patents [OSTI]

A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

Paglieroni, David W; Beer, N Reginald; Bond, Steven W; Top, Philip L; Chambers, David H; Mast, Jeffrey E; Donetti, John G; Mason, Blake C; Jones, Steven M

2014-10-07T23:59:59.000Z

347

J. Clairambault Theorems to treat cancer? Can theorems help treat cancer?  

E-Print Network [OSTI]

J. Clairambault Theorems to treat cancer? Can theorems help treat cancer? Jean Clairambault 1 INRIA who treat patients with can- cer? Can mathematics have an impact on cancer biology? Is mathematics more than just a tool in the hands of [a few open-minded] physicians willing to understand and treat

Paris-Sud XI, Université de

348

Eur J Cancer Prev. Author manuscript Determinants of non-compliance to recommendations on breast cancer  

E-Print Network [OSTI]

Eur J Cancer Prev. Author manuscript Page /1 11 Determinants of non-compliance to recommendations on breast cancer screening among women participating in the French E3N cohort study Flamant Camille , Gauthier Estelle , Clavel-Chapelon Fran oiseç * E3N, Nutrition, hormones et cancer: pid miologie et pr

Paris-Sud XI, Université de

349

Perspectives on the mesenchymal origin of metastatic cancer  

E-Print Network [OSTI]

of metastasis. Nature Reviews Cancer, 9(4), 239252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

Huysentruyt, Leanne C.; Seyfried, Thomas N.

2010-01-01T23:59:59.000Z

350

Targeting Tyrosine Kinases and Autophagy in Prostate Cancer  

E-Print Network [OSTI]

kinases and cellular signaling in prostate cancer. In: ChungW, Simons J (eds) Prostate cancer: biology, genetics and theexpres- sion in prostate cancer cells. Endocrinology 142:21

Kung, Hsing-Jien

2011-01-01T23:59:59.000Z

351

The genomic complexity of primary human prostate cancer  

E-Print Network [OSTI]

Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

Carter, Scott Lambert

352

Improving Process Cooling Tower Eddiciency  

E-Print Network [OSTI]

of the Thrity-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 7 Improving Cooling Tower Efficiency ? Two Improvements in Capacity/Performance 1. Filtration for water quality control Side stream filtration Make up water quality...-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 2 Types of Cooling Towers Forced Draft Towers ESL-IE-13-05-08 Proceedings of the Thrity-Fifth Industrial Energy Technology Conference New Orleans, LA. May 21-24, 2013 3 Types...

Turpish, W.

2013-01-01T23:59:59.000Z

353

Improving Solar-Cell Efficiency  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching.348 270 300 219Improvements toProjectsImprovingHow to

354

Supernova Neutrinos Detection On Earth  

E-Print Network [OSTI]

In this paper, we first discuss the detection of supernova neutrino on Earth. Then we propose a possible method to acquire information about $\\theta_{13}$ smaller than $1.5^\\circ$ by detecting the ratio of the event numbers of different flavor supernova neutrinos. Such an sensitivity cannot yet be achieved by the Daya Bay reactor neutrino experiment.

Xin-Heng Guo; Ming-Yang Huang; Bing-Lin Young

2009-05-12T23:59:59.000Z

355

COMPACT CdZnTe-BASED GAMMA CAMERA FOR PROSTATE CANCER IMAGING  

SciTech Connect (OSTI)

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.

CUI, Y.; LALL, T.; TSUI, B.; YU, J.; MAHLER, G.; BOLOTNIKOV, A.; VASKA, P.; DeGERONIMO, G.; O'CONNOR, P.; MEINKEN, G.; JOYAL, J.; BARRETT, J.; CAMARDA, G.; HOSSAIN, A.; KIM, K.H.; YANG, G.; POMPER, M.; CHO, S.; WEISMAN, K.; SEO, Y.; BABICH, J.; LaFRANCE, N.; AND JAMES, R.B.

2011-10-23T23:59:59.000Z

356

Particle detection systems and methods  

DOE Patents [OSTI]

Techniques, apparatus and systems for detecting particles such as muons and neutrons. In one implementation, a particle detection system employs a plurality of drift cells, which can be for example sealed gas-filled drift tubes, arranged on sides of a volume to be scanned to track incoming and outgoing charged particles, such as cosmic ray-produced muons. The drift cells can include a neutron sensitive medium to enable concurrent counting of neutrons. The system can selectively detect devices or materials, such as iron, lead, gold, uranium, plutonium, and/or tungsten, occupying the volume from multiple scattering of the charged particles passing through the volume and can concurrently detect any unshielded neutron sources occupying the volume from neutrons emitted therefrom. If necessary, the drift cells can be used to also detect gamma rays. The system can be employed to inspect occupied vehicles at border crossings for nuclear threat objects.

Morris, Christopher L.; Makela, Mark F.

2010-05-11T23:59:59.000Z

357

Rapid deployment intrusion detection system  

SciTech Connect (OSTI)

A rapidly deployable security system is one that provides intrusion detection, assessment, communications, and annunciation capabilities; is easy to install and configure; can be rapidly deployed, and is reusable. A rapidly deployable intrusion detection system (RADIDS) has many potential applications within the DOE Complex: back-up protection for failed zones in a perimeter intrusion detection and assessment system, intrusion detection and assessment capabilities in temporary locations, protection of assets during Complex reconfiguration, and protection in hazardous locations, protection of assets during Complex reconfiguration, and protection in hazardous locations. Many DOE user-need documents have indicated an interest in a rapidly deployable intrusion detection system. The purpose of the RADIDS project is to design, develop, and implement such a system. 2 figs.

Graham, R.H.

1997-08-01T23:59:59.000Z

358

Detecting Eccentric Globular Cluster Binaries with LISA  

E-Print Network [OSTI]

The energy carried in the gravitational wave signal from an eccentric binary is spread across several harmonics of the orbital frequency. The inclusion of the harmonics in the analysis of the gravitational wave signal increases the signal-to-noise ratio of the detected signal for binaries whose fundamental frequency is below the galactic confusion-limited noise cut-off. This can allow for an improved angular resolution for sources whose orbital period is greater than 2000 s. Globular cluster sources include possible binary black holes and neutron stars which may have high eccentricities. Cluster dynamics may also enhance the eccentricities of double white dwarf binaries and white dwarf-neutron star binaries over the galactic sources. Preliminary results of the expected signal-to-noise ratio for selected globular cluster binaries are presented.

M. Benacquista

2001-06-05T23:59:59.000Z

359

R&D proliferation detection  

National Nuclear Security Administration (NNSA)

Security program collaborates with partners world-wide to improve the security of proliferation-sensitive materials, particularly weapons-usable nuclear material in both civilian...

360

Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group  

E-Print Network [OSTI]

quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):26173. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ .[.nudeic.]. .Iadd.nucleic .Iaddend.acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2009-10-06T23:59:59.000Z

362

Chromosome-Specific Staining To Detect Genetic Rearrangements Associated With Chromosome 3 And/Or Chromosone 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray; Joe W. (Livermore, CA); Pinkel; Daniel (Walnut Creek, CA); Kallioniemi; Olli-Pekka (Tampere, FI); Kallioniemi; Anne (Tampere, FI); Sakamoto; Masaru (Tokyo, JP)

2002-02-05T23:59:59.000Z

363

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2008-09-09T23:59:59.000Z

364

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nudeic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Kallioniemi, Olli-Pekka (Tampere, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2002-01-01T23:59:59.000Z

365

Sustaining Performance Improvements in Energy Intensive Industries  

E-Print Network [OSTI]

Experience has shown that significant opportunity for performance improvements exists in energy intensive operations. Often, efforts to improve efficiency focus on vendor-led initiatives to improve operations of particular equipment. This approach...

Moore, D. A.

2005-01-01T23:59:59.000Z

366

Proteogenomic characterization of human colon and rectal cancer...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

characterization of human colon and rectal cancer. Proteogenomic characterization of human colon and rectal cancer. Abstract: We analyzed proteomes of colon and rectal tumors...

367

Biocompatible core-shell magnetic nanoparticles for cancer treatment...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biocompatible core-shell magnetic nanoparticles for cancer treatment. Biocompatible core-shell magnetic nanoparticles for cancer treatment. Abstract: Non-toxic magnetic...

368

Isotope production facility produces cancer-fighting actinium  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

369

Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Immunosensor for Cancer Biomarker Based on Dual Signal Amplification Strategy of Graphene Sheets and Multi-Enzyme Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

370

Integrated genomics in prostate cancer: defining the lethal phenotype .  

E-Print Network [OSTI]

??Prostate cancer is the second leading cause of cancer death in Australian men. However, it has a wide spectrum of biological aggressiveness from those that (more)

Hong, Matthew Kok-Hao

2014-01-01T23:59:59.000Z

371

Managing Critical Management Improvement Initiatives  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Provides requirements and responsibilities for planning, executing and assessing critical management improvement initiatives within DOE. DOE N 251.59, dated 9/27/2004, extends this Notice until 10/01/2005. Archived 11-8-10. Does not cancel other directives.

2003-10-01T23:59:59.000Z

372

Zymomonas with improved xylose utilization  

DOE Patents [OSTI]

Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.

Viitanen, Paul V. (West Chester, PA); Tao, Luan (Havertown, PA); Zhang, Yuying (New Hope, PA); Caimi, Perry G. (Kennett Square, PA); McCutchen, Carol M. (Wilmington, DE); McCole, Laura (East Fallowfield, PA); Zhang, Min (Lakewood, CO); Chou, Yat-Chen (Lakewood, CO); Franden, Mary Ann (Centennial, CO)

2011-08-16T23:59:59.000Z

373

What are Improvement Partnerships? "VCHIPisaperfectexampleofhowstategroupscancometogetheraroundacommongoaland  

E-Print Network [OSTI]

and knowledge, IPs increase the strength and quality of health care reform efforts for the nation as a whole the will and knowledge for sustainable change across the health care delivery system. Other states have expressed measurement- based efforts and a systems approach to improve the quality of children's health care. IPs draw

Hayden, Nancy J.

374

Improved photovoltaic cells and electrodes  

DOE Patents [OSTI]

Improved photovoltaic cells and electrodes for use therein, particularly electrodes employing amorphous silicon or polyacetylene coating are produced by a process which includes filling pinholes or porous openings in the coatings by electrochemical oxidation of selected monomers to deposit insulating polymer in the openings.

Skotheim, T.A.

1983-06-29T23:59:59.000Z

375

Improving Inventory Control Using Forecasting  

E-Print Network [OSTI]

EMGT 835 FIELD PROJECT: Improving Inventory Control Using Forecasting By Juan Mario Balandran jmbg@hotmail.com Master of Science The University of Kansas Fall Semester, 2005 An EMGT Field Project report submitted...............................................................................................................................................10 Current Inventory Forecast Process ...........................................................................................10 Development of Alternative Forecast Process...

Balandran, Juan

2005-12-16T23:59:59.000Z

376

Improvement February 28 & 29, 2012  

E-Print Network [OSTI]

HR Process Improvement Forums February 28 & 29, 2012 #12;Agenda Updates ­ New initiatives Resources Education Verification Request ­ Found in Employment Forms on the HR Web Page Researching other avenues ­ Diploma Translations ­ NM Department of Education for verification of High School diploma #12

New Mexico, University of

377

UNCONVENTIONAL METHODS FOR YIELD IMPROVEMENT  

E-Print Network [OSTI]

methods (active heating and cooling, directional solidifi- cation) Novel yield improvement techniques through a vari- ety of active heating and cooling schemes. It is envisioned that the techniques will allow techniques for decreasing the size and number of risers re- quired to produce quality castings

Beckermann, Christoph

378

Magnetic force microscopy method and apparatus to detect and image currents in integrated circuits  

DOE Patents [OSTI]

A magnetic force microscopy method and improved magnetic tip for detecting and quantifying internal magnetic fields resulting from current of integrated circuits. Detection of the current is used for failure analysis, design verification, and model validation. The interaction of the current on the integrated chip with a magnetic field can be detected using a cantilevered magnetic tip. Enhanced sensitivity for both ac and dc current and voltage detection is achieved with voltage by an ac coupling or a heterodyne technique. The techniques can be used to extract information from analog circuits.

Campbell, Ann. N. (13170-B Central SE #188, Albuquerque, NM 87123); Anderson, Richard E. (2800 Tennessee NE, Albuquerque, NM 87110); Cole, Jr., Edward I. (2116 White Cloud NE, Albuquerque, NM 87112)

1995-01-01T23:59:59.000Z

379

Magnetic force microscopy method and apparatus to detect and image currents in integrated circuits  

DOE Patents [OSTI]

A magnetic force microscopy method and improved magnetic tip for detecting and quantifying internal magnetic fields resulting from current of integrated circuits are disclosed. Detection of the current is used for failure analysis, design verification, and model validation. The interaction of the current on the integrated chip with a magnetic field can be detected using a cantilevered magnetic tip. Enhanced sensitivity for both ac and dc current and voltage detection is achieved with voltage by an ac coupling or a heterodyne technique. The techniques can be used to extract information from analog circuits. 17 figs.

Campbell, A.N.; Anderson, R.E.; Cole, E.I. Jr.

1995-11-07T23:59:59.000Z

380

Leak detection, monitoring, and mitigation technology trade study update  

SciTech Connect (OSTI)

This document is a revision and update to the initial report that describes various leak detection, monitoring, and mitigation (LDMM) technologies that can be used to support the retrieval of waste from the single-shell tanks (SST) at the Hanford Site. This revision focuses on the improvements in the technical performance of previously identified and useful technologies, and it introduces new technologies that might prove to be useful.

HERTZEL, J.S.

1998-11-10T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Hybrid Detection of UHECR with the Pierre Auger Observatory  

E-Print Network [OSTI]

The Pierre Auger Observatory detects ultra-high energy cosmic rays by implementing two complementary air-shower techniques. The combination of a large ground array and fluorescence detectors, known as the "hybrid" concept, means that a rich variety of measurements can be made on a single shower, providing much improved information over what is possible with either detector alone. In this paper the hybrid reconstruction approach and its performance are described.

Miguel Mostafa; for the Pierre Auger Collaboration

2006-07-31T23:59:59.000Z

382

Targeting Organic Anion Transporting Polypeptides in Cancer to Improve Diagnostics and Therapy  

E-Print Network [OSTI]

Organic Anion Transporting Polypeptides (OATPs) are multispecific transport proteins that mediate the uptake of numerous endogenous and exogenous compounds into cells. Recently, OATPs have been shown to have altered ...

Hays, Amanda Lynne

2012-08-12T23:59:59.000Z

383

Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification  

E-Print Network [OSTI]

The extracellular matrix (ECM) has been shown to be a significant source of hindrance to the transport of macromolecules in solid tumors. This thesis shows that by limiting their interstitial transport, the tumor ECM can ...

Mok, Wilson

2008-01-01T23:59:59.000Z

384

Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer  

E-Print Network [OSTI]

company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

2013-01-01T23:59:59.000Z

385

Smart Grid Investments Improve Grid Reliability, Resilience,...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Investments Improve Grid Reliability, Resilience, and Storm Responses (November 2014) Smart Grid Investments Improve Grid Reliability, Resilience, and Storm Responses (November...

386

RELIABILITY IMPROVEMENT OF BART TRAIN CONTROL  

E-Print Network [OSTI]

it was a response to the reliability problems introduced by~atelyowned rights. RELIABILITY IMPROVEMENT OF BART VEHICLEtask group to improve the reliability of the Bay Area Rapid

Turner, D.B.

2011-01-01T23:59:59.000Z

387

Funding Opportunity Webinar - Advancing Solutions To Improve...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Funding Opportunity Webinar - Advancing Solutions To Improve the Energy Efficiency of US Commercial Buildings Funding Opportunity Webinar - Advancing Solutions To Improve the...

388

Advanced Manufacturing Initiative Improves Turbine Blade Productivity...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Advanced Manufacturing Initiative Improves Turbine Blade Productivity Advanced Manufacturing Initiative Improves Turbine Blade Productivity May 20, 2011 - 2:56pm Addthis This is an...

389

Industrial Energy Efficiency Projects Improve Competitiveness...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Industrial Energy Efficiency Projects Improve Competitiveness and Protect Jobs Industrial Energy Efficiency Projects Improve Competitiveness and Protect Jobs U.S. Department of...

390

Water Efficiency Improvements at Various Environmental Protection...  

Broader source: Energy.gov (indexed) [DOE]

Water Efficiency Improvements at Various Environmental Protection Agency Sites: Best Management Practices Case Study 12-LaboratoryMedical Equipment Water Efficiency Improvements...

391

Inhibiting Individual Notch Receptors Improves Treatment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of any of the four human Notch receptors has been linked to diseases, particularly cancer, making the Notch pathway a compelling target for new drug studies. A research team...

392

Improved monoclonal antibodies to halodeoxyuridine  

DOE Patents [OSTI]

The development, method of production, characterization and methods of use of two hybridomas, CIdU-1 (ATCC Accession No. HB-8321) and CIdU-2 (ATCC Accession No. HB-8320), are described. These secrete IgG/sub 1/(K) immunoglobulins that react with halodeoxyuridine (HdU or halodU) such as bromo, chloro, fluoro and iodo deoxyuridine (BrdU, CldU, FdU and IdU), whether these are free in solution or incorporated into single stranded DNA in whole cells. The antibodies do not react with naturally occurring free nucleic acids or with deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) polymers. These antibodies are suitable for use in enzyme immunoassays for free CldU, FdU, IdU and BrdU and for detecting cells with these nucleotides incorporated into them. The monoclonal antibodies are useful in the detection of the sensitivity of tumor cells to specific chemotherapeutic agents, in the measurement of the rate of cellular DNA synthesis, in the measurement of the rate of proliferation of normal and malignant cells and in the detection of HPRT deficiency in cells. 1 tab.

Vanderlaan, M.; Dolbeare, F.A.; Gray, J.W.; Thomas, C.B.

1983-10-18T23:59:59.000Z

393

Impact of Concomitant Chemotherapy on Outcomes of Radiation Therapy for Head-and-Neck Cancer: A Population-Based Study  

SciTech Connect (OSTI)

Purpose: Clinical trials have shown that the addition of chemotherapy to radiation therapy (RT) improves survival in advanced head-and-neck cancer. The objective of this study was to describe the effectiveness of concomitant chemoradiation therapy (C-CRT) in routine practice. Methods and Materials: This was a population-based cohort study. Electronic records of treatment from all provincial cancer centers were linked to a population--based cancer registry to describe the adoption of C-CRT for head-and-neck cancer patients in Ontario, Canada. The study population was then divided into pre- and postadoption cohorts, and their outcomes were compared. Results: Between 1992 and 2008, 18,867 patients had diagnoses of head-and-neck cancer in Ontario, of whom 7866 (41.7%) were treated with primary RT. The proportion of primary RT cases that received C-CRT increased from 2.2% in the preadoption cohort (1992-1998) to 39.3% in the postadoption cohort (2003-2008). Five-year survival among all primary RT cases increased from 43.6% in the preadoption cohort to 51.8% in the postadoption cohort (P<.001). Over the same period, treatment-related hospital admissions increased significantly, but there was no significant increase in treatment-related deaths. Conclusions: C-CRT was widely adopted in Ontario after 2003, and its adoption was temporally associated with an improvement in survival.

Gupta, Shlok; Kong, Weidong [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Booth, Christopher M. [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Department of Community Health and Epidemiology, Queens University, Kingston, Ontario (Canada)

2014-01-01T23:59:59.000Z

394

Method for detecting an image of an object  

DOE Patents [OSTI]

A method for detecting an absorption, refraction and scatter image of an object by independently analyzing, detecting, digitizing, and combining images acquired on a high and a low angle side of a rocking curve of a crystal analyzer. An x-ray beam which is generated by any suitable conventional apparatus can be irradiated upon either a Bragg type crystal analyzer or a Laue type crystal analyzer. Images of the absorption, refraction and scattering effects are detected, such as on an image plate, and then digitized. The digitized images are simultaneously solved, preferably on a pixel-by-pixel basis, to derive a combined visual image which has dramatically improved contrast and spatial resolution over an image acquired through conventional radiology methods.

Chapman, Leroy Dean (4 Vermont Cir., Bolingbrook, IL 60440); Thomlinson, William C. (32 E. Masem, East Patchogue, NY 11772); Zhong, Zhong (Apt. I 1131 Chaping 700 E. Loop Rd., Stonybrook, NY 11790)

1999-11-16T23:59:59.000Z

395

Ultrafast laser based coherent control methods for explosives detection  

SciTech Connect (OSTI)

The detection of explosives is a notoriously difficult problem, especially at stand-off, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring Optimal Dynamic Detection of Explosives (ODD-Ex), which exploits the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity to explosives signatures while dramatically improving specificity, particularly against matrix materials and background interferences. These goals are being addressed by operating in an optimal non-linear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe subpulses. Recent results will be presented.

Moore, David Steven [Los Alamos National Laboratory

2010-12-06T23:59:59.000Z

396

The Purdue University Center for Cancer Research is continually exploring new methods of treating cancer, techniques to detect cancer and preventative  

E-Print Network [OSTI]

. Brown Mr. Donald L. Dunaway Mrs. Joyce Pahl Foley and Mr. Roger Neil Foley Mrs. Sharron S. Hillabrand. Davisson Mr. Ken C. Decker and Mrs. Kitty Decker Mr. James S. DeHaven and Mrs. Ann DeHaven Ms. Marcia L. Flynn Mrs. Sally M. Friend and Mr. James R. Friend Mrs. Bernice Heath Geiselman and Dr. Doyle Geiselman

Wei, Alexander

397

EDITORIAL Open Access Toward integrative cancer immunotherapy  

E-Print Network [OSTI]

alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells themselves. There is now widespread appreciation that the progressive growth and metastatic spread of cancer cells requires the cooperation of normal host cells (endothelial cells

Paris-Sud XI, Université de

398

Restoration of normal phenotype in cancer cells  

DOE Patents [OSTI]

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

Bissell, M.J.; Weaver, V.M.

1998-12-08T23:59:59.000Z

399

Restoration of normal phenotype in cancer cells  

DOE Patents [OSTI]

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

1998-01-01T23:59:59.000Z

400

Diet and Cancer Are Cooked Meats Involved  

ScienceCinema (OSTI)

Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

LLNL - University of California Television

2009-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Detectability of Inflationary Gravitational Waves with Microwave Background Polarization  

E-Print Network [OSTI]

Inflation predicts specific relations between the amplitudes and spectral indices of the primordial spectrum of density (scalar metric) perturbations and gravitational waves (tensor metric perturbations). Detection of a stochastic gravitational-wave background is essential for identifying this unmistakable signature. Polarization of the cosmic microwave background can isolate these tensor modes in a model-independent way and thereby circumvent the cosmic-variance limit to detecting a small tensor signal with only a temperature map. Here we assess the detectability of a gravity-wave background with a temperature and polarization map. For detector sensitivities better than $10-20 \\mu K \\sqrt{sec}$, the sensitivity to a tensor signal is always dominated by the polarization map. With a detector sensitivity of order $1 \\mu K \\sqrt{sec}$, polarization could improve on a temperature-map sensitivity to tensor modes by two to three orders of magnitude. Even a small amount of reionization substantially enhances tensor-mode detectability. We also argue that the sensitivity of the Planck Surveyor to tensor modes is significantly improved with polarization, even taking into account the resulting degradation of the intensity determination in the high-frequency channels.

Marc Kamionkowski; Arthur Kosowsky

1997-05-28T23:59:59.000Z

402

Novel Pattern Recognition Techniques for Improved Target Detection in Hyperspectral Imagery  

E-Print Network [OSTI]

first-order Markovbased scheme to exploit correlation between bands. Using these models, we present two techniques for meeting these challenges-the kernel-based support vector data description (SVDD) and spectral fringe-adjusted joint transform...

Sakla, Wesam Adel

2011-02-22T23:59:59.000Z

403

Thermo-optical modulation for improved ultrasonic fatigue crack detection in Ti6Al4V  

E-Print Network [OSTI]

scatterers, such as surface grooves, corrosion pits, coarse grains, etc. that might hide the fatigue crack to grow at unexpectedly high growth rates well below the large-crack threshold in aluminum, aluminumlithium) and secondary irregulari- ties (e.g. uneven machining, mechanical wear, corrosion, etc.). Second

Nagy, Peter B.

404

Design and optimization of polymeric silole and boronate photoluminescent probes for improved explosives detection applications  

E-Print Network [OSTI]

through thermal and UV degradation of the peroxide basedonset of photo- degradation at 1 min UV light. atmospheric

Sanchez, Jason C.

2008-01-01T23:59:59.000Z

405

An improved approach for robust road marking detection and tracking applied to multi-lane estimation.  

E-Print Network [OSTI]

provided a great number of devices on many types of automatic vehicle guidance and security systems of an environment surrounding an ego-vehicle. Indeed, this information provides relative vehicle location evident the automation of the driving task is probably a solution in the reduction of the road injuries

Paris-Sud XI, Université de

406

Improving dielectric performance in anodic aluminum oxide via detection and passivation of defect states  

SciTech Connect (OSTI)

The electronic and ionic transports in 3256?nm thick anodic aluminum oxide films are investigated before and after a 1-h anneal at 200400?C in argon. Results are correlated to their defect density as measured by the Mott-Schottky technique. Solid state measurements show that electronic conduction upon annealing is hindered by an increase in the Schottky emission barrier, induced by a reduction in dopant density. Using an electrochemical contact, the films fail rapidly under cathodic polarization, unless defect density is decreased down to 10{sup 17}?cm{sup ?3}, resulting in a three order of magnitude reduction in current and no visible gas evolution. Under anodic polarization, the decrease in defect density delays the onset of ionic conduction as well as further oxide growth and failure.

Mibus, M.; Zangari, G. [Department of Materials Science and Engineering, University of Virginia, Charlottesville, Virginia 22904 (United States); Jensen, C. [Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 (United States); Hu, X.; Reed, M. L. [Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904 (United States); Knospe, C. [Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, Virginia 22904 (United States)

2014-06-16T23:59:59.000Z

407

Improved geomembrane damage/leak detection through co-extrusion technology  

SciTech Connect (OSTI)

There has been a considerable advancement in technology available for providing a barrier system in the containment and storage of waste materials. Natural soil liners several feet in thickness have been augmented by factory-produced, synthetic materials that have permeability coefficients several orders of magnitude lower than any natural soil system. To carry the systems approach one step farther, engineers use multiple layers of synthetics separated at times by layers of clay offering a redundant composite barrier to protect the groundwater. Each geosynthetic material offers its own unique contribution to the system based upon its physical characteristics. Co-extrusion -- the process of combining two or more materials into a single product, through a single process -- is now revolutionizing the liner industry.

Messmer, D.P.; Cadwallader, M. (Gundle Lining Systems, Inc., Houston, TX (United States))

1994-04-01T23:59:59.000Z

408

Reducing risk in basin scale sequestration: A Bayesian model selection framework for improving detection  

E-Print Network [OSTI]

Geological CO[subscript 2] sequestration is a key technology for mitigating atmospheric greenhouse gas concentrations while providing low carbon energy. Deployment of sequestration at scales necessary for a material ...

Seto, C.J.

409

Building on Clues: Improving Methods to Help Detect and Characterize Terrorist Activity  

E-Print Network [OSTI]

Security Solutions www.ihssnc.org #12;Project Overview · Problem: Limited guidance on how to collect" Responsible for Plots Within the US, 1999-2009 Anti-Abortion Animal Rights Anti-Muslim Right Left Ideology

McShea, Daniel W.

410

The development of an improved methodology for the detection of Arcobacter spp. in foods  

E-Print Network [OSTI]

negative rods were examined for their effect on growth of these organisms. Components were evaluated for their ability to recover Arcobacter on a solid medium when incubated aerobically at 30OC for up to 7z11rs. After initial evaluations, five formulas...

Johnson, Lee Graydon

1998-01-01T23:59:59.000Z

411

Trace Explosive Detection Using Nanosensors  

SciTech Connect (OSTI)

Selective and sensitive detection of explosives is very important in countering terrorist threats. Detecting trace explosives has become a very complex and expensive endeavor because of a number of factors, such as the wide variety of materials that can be used as explosives, the lack of easily detectable signatures, the vast number of avenues by which these weapons can be deployed, and the lack of inexpensive sensors with high sensitivity and selectivity. High sensitivity and selectivity, combined with the ability to lower the deployment cost of sensors using mass production, is essential in winning the war on explosives-based terrorism. Nanosensors have the potential to satisfy all the requirements for an effective platform for the trace detection of explosives.

Senesac, Larry R [ORNL; Thundat, Thomas George [ORNL

2008-01-01T23:59:59.000Z

412

Intrusion detection sensor testing tools  

SciTech Connect (OSTI)

Intrusion detection sensors must be frequently tested to verify that they are operational, and they must be periodically tested to verify that they are functioning at required performance levels. Concerns involving this testing can include: The significant amount of manpower required, inconsistent results due to variability in methods and personnel, exposure of personnel to hazardous environments, and difficulty in obtaining access to the areas containing some of the intrusion sensors. To address these concerns, the Department of Energy directed Sandia National Labs. to develop intrusion detection sensor testing tools. Over the past two years Sandia has developed several sensor testing tool prototypes. This paper describes the evolution of an exterior intrusion detection sensor tester and automatic data logger, and also describes various interior intrusion detection sensor test fixtures that can be remotely activated to simulate an intruder.

Hayward, D.R.

1994-08-01T23:59:59.000Z

413

Mercury Detection with Gold Nanoparticles  

E-Print Network [OSTI]

R. J. Warmack, Detection of mercury vapor using resonatingA surface acoustic wave mercury vapor sensor, Ieee Trans.N. E. Selin, Integrating mercury science and policy in the

Crosby, Jeffrey

2013-01-01T23:59:59.000Z

414

Improved Fission Neutron Data Base for Active Interrogation of Actinides  

SciTech Connect (OSTI)

This project will develop an innovative neutron detection system for active interrogation measurements. Many active interrogation methods to detect fissionable material are based on the detection of neutrons from fission induced by fast neutrons or high-energy gamma rays. The energy spectrum of the fission neutrons provides data to identify the fissionable isotopes and materials such as shielding between the fissionable material and the detector. The proposed path for the project is as follows. First, the team will develop new neutron detection systems and algorithms by Monte Carlo simulations and bench-top experiments. Next, They will characterize and calibrate detection systems both with monoenergetic and white neutron sources. Finally, high-fidelity measurements of neutron emission from fissions induced by fast neutrons will be performed. Several existing fission chambers containing U-235, Pu-239, U-238, or Th-232 will be used to measure the neutron-induced fission neutron emission spectra. The challenge for making confident measurements is the detection of neutrons in the energy ranges of 0.01 1 MeV and above 8 MeV, regions where the basic data on the neutron energy spectrum emitted from fission is least well known. In addition, improvements in the specificity of neutron detectors are required throughout the complete energy range: they must be able to clearly distinguish neutrons from other radiations, in particular gamma rays and cosmic rays. The team believes that all of these challenges can be addressed successfully with emerging technologies under development by this collaboration. In particular, the collaboration will address the area of fission neutron emission spectra for isotopes of interest in the advanced fuel cycle initiative (AFCI).

Pozzi, Sara; Czirr, J. Bart; Haight, Robert; Kovash, Michael; Tsvetkov, Pavel

2013-11-06T23:59:59.000Z

415

Steam Cracker Furnace Energy Improvements  

E-Print Network [OSTI]

Channel, ~ 25 mi. east of Houston ? Includes 4 manufacturing sites, 2 technology/engineering offices ?Significant community involvement Baytown Refinery Page 4 Steam Cracking to Olefins ? Process 60+ years old; ExxonMobil one of pioneers... Steam Cracker Furnace Energy Improvements Tim Gandler Energy Coordinator Baytown Olefins Plant, Baytown Tx 2010 Industrial Energy Technology Conference May, 2010 Page 2 ? Baytown Complex ? Steam Cracking to Olefins ? Furnace overview...

Gandler, T.

416

Process Improvement at Army Installations  

E-Print Network [OSTI]

recommendations are for the Fill and Press line where most of the Level I focused LESSONS LEARNED On completion of the project, the researchers assessed the results and some of the 198 ESL-IE-97-04-31 Proceedings from the Nineteenth Industrial Energy.... Finally, the energy issues included initiate an energy team; install energy efficient lighting; and decommission unused steam lines. After the first cost, savings, and simple payback time was calculated for all of the proposed improvements, a...

Northrup, J.; Smith, E. D.; Lin, M.; Baird, J.

417

LOS ANGELES, CA, DISTRICT IMPROVEMENTS  

E-Print Network [OSTI]

33-1 LOS ANGELES, CA, DISTRICT IMPROVEMENTS Navigation Page 1. Channel Islands Harbor, CA 33-2 2. Imperial Beach, Silver Strand Shoreline, CA 33-2 3. LA-LB Harbors (LA Harbor), CA 33-2 4. Los Angeles Harbor Main Channel Deepen, CA 33-2 5. Marina Del Rey, CA 33-3 6. Morro Bay Harbor, CA 33-3 7. Newport

US Army Corps of Engineers

418

Improving and Observing Lithiation Reactions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for planning experimental workImproving Reuse

419

Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Noscapine inhibited cell viability of colon cancer in a time- and dose- dependent manner. Black-Right-Pointing-Pointer G{sub 2}/M phase arrest and chromatin condensation and nuclear fragmentation were induced. Black-Right-Pointing-Pointer Noscapine promoted apoptosis via mitochondrial pathways. Black-Right-Pointing-Pointer Tumorigenicity was inhibited by noscapine. -- Abstract: Noscapine, a phthalide isoquinoline alkaloid derived from opium, has been widely used as a cough suppressant for decades. Noscapine has recently been shown to potentiate the anti-cancer effects of several therapies by inducing apoptosis in various malignant cells without any detectable toxicity in cells or tissues. However, the mechanism by which noscapine induces apoptosis in colon cancer cells remains unclear. The signaling pathways by which noscapine induces apoptosis were investigated in colon cancer cell lines treated with various noscapine concentrations for 72 h, and a dose-dependent inhibition of cell viability was observed. Noscapine effectively inhibited the proliferation of LoVo cells in vitro (IC{sub 50} = 75 {mu}M). This cytotoxicity was reflected by cell cycle arrest at G{sub 2}/M and subsequent apoptosis, as indicated by increased chromatin condensation and fragmentation, the upregulation of Bax and cytochrome c (Cyt-c), the downregulation of survivin and Bcl-2, and the activation of caspase-3 and caspase-9. Moreover, in a xenograft tumor model in mice, noscapine injection clearly inhibited tumor growth via the induction of apoptosis, which was demonstrated using a TUNEL assay. These results suggest that noscapine induces apoptosis in colon cancer cells via mitochondrial pathways. Noscapine may be a safe and effective chemotherapeutic agent for the treatment of human colon cancer.

Yang, Zi-Rong; Liu, Meng; Peng, Xiu-Lan; Lei, Xiao-Fei; Zhang, Ji-Xiang [Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province (China)] [Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province (China); Dong, Wei-Guo, E-mail: dongwg1966@yahoo.com.cn [Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province (China)] [Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province (China)

2012-05-11T23:59:59.000Z

420

JOB DESCRIPTION Title: Continuous Improvement Specialist  

E-Print Network [OSTI]

or Six Sigma-based continuous improvement methods. Certification: Six Sigma Black Belt or Green Belt

Heller, Barbara

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Forty-Four Pass Fibre Optic Loop for Improving the Sensitivity of Surface Plasmon Resonance Sensors  

E-Print Network [OSTI]

A forty-four pass fibre optic surface plasmon resonance sensor that enhances detection sensitivity according to the number of passes is demonstrated for the first time. The technique employs a fibre optic recirculation loop that passes the detection spot forty- four times, thus enhancing sensitivity by a factor of forty-four. Presently, the total number of passes is limited by the onset of lasing action of the recirculation loop. This technique offers a significant sensitivity improvement for various types of plasmon resonance sensors that may be used in chemical and biomolecule detections.

Chin B Su; Jun Kameoka

2007-09-21T23:59:59.000Z

422

Real-time method for establishing a detection map for a network of sensors  

DOE Patents [OSTI]

A method for establishing a detection map of a dynamically configurable sensor network. This method determines an appropriate set of locations for a plurality of sensor units of a sensor network and establishes a detection map for the network of sensors while the network is being set up; the detection map includes the effects of the local terrain and individual sensor performance. Sensor performance is characterized during the placement of the sensor units, which enables dynamic adjustment or reconfiguration of the placement of individual elements of the sensor network during network set-up to accommodate variations in local terrain and individual sensor performance. The reconfiguration of the network during initial set-up to accommodate deviations from idealized individual sensor detection zones improves the effectiveness of the sensor network in detecting activities at a detection perimeter and can provide the desired sensor coverage of an area while minimizing unintentional gaps in coverage.

Nguyen, Hung D; Koch, Mark W; Giron, Casey; Rondeau, Daniel M; Russell, John L

2012-09-11T23:59:59.000Z

423

IN A CUREUF HEALTH CANCER CENTER NEWS SPRING 2014  

E-Print Network [OSTI]

care and research for the Southeast's most comprehensive academic health center. In each issue, weIN A CUREUF HEALTH CANCER CENTER NEWS Believe SPRING 2014 PAGE6 #12;www.cancer.ufl.eduBelieve in a Cure//Spring 20142 Believe in a Cure is the newsletter for the UF Health Cancer Center, home to cancer

Roy, Subrata

424

lung cancer smoke-free 6 One man's  

E-Print Network [OSTI]

Fighting lung cancer Living smoke-free 6 One man's mission85 #12;Cure is the newsletter for the University of Florida Shands Cancer Center, home to cancer care and research for the Southeast's most? For more information about care and services offered at the UF Shands Cancer Center, call 352

Roy, Subrata

425

Metabolism and proliferation share common regulatory pathways in cancer  

E-Print Network [OSTI]

Metabolism and proliferation share common regulatory pathways in cancer cells. Vanessa Fritz, proliferation, and cancer inserm-00491405,version1-11Jun2010 Author manuscript, published in "Oncogene 2010;29(31):4369-77" DOI : 10.1038/onc.2010.182 #12;Metabolism, proliferation and cancer Fritz and Fajas 2 Abstract Cancer

Boyer, Edmond

426

Cancer Cells DOI: 10.1002/anie.201103189  

E-Print Network [OSTI]

Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer · micromachines · nanorobots · nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

Zhang, Liangfang

427

Cancer is a genetic disease1 . Although environmental  

E-Print Network [OSTI]

Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

Nowak, Martin A.

428

"Skin Cancer-What to Look For" Rochester Recreation  

E-Print Network [OSTI]

"Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

Goldman, Steven A.

429

Laser-induced differential normalized fluorescence method for cancer diagnosis  

DOE Patents [OSTI]

An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample. 5 figs.

Vo-Dinh, T.; Panjehpour, M.; Overholt, B.F.

1996-12-03T23:59:59.000Z

430

Laser-induced differential normalized fluorescence method for cancer diagnosis  

DOE Patents [OSTI]

An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample.

Vo-Dinh, Tuan (Knoxville, TN); Panjehpour, Masoud (Knoxville, TN); Overholt, Bergein F. (Knoxville, TN)

1996-01-01T23:59:59.000Z

431

Improved Biomass Cooking Stoves and Improved Stove Emission Equipment  

SciTech Connect (OSTI)

In developing countries, there is an urgent need for access to safe, efficient, and more affordable cooking technologies. Nearly 2.5 billion people currently use an open fire or traditional cookstove to prepare their meals, and recent models predict that use of biomass for cooking will continue to be the dominant energy use in rural, resource-poor households through 2030. For these families, cooking poses serious risks to health, safety, and income. An alarming 4 million people, primarily women and children, die prematurely each year from indoor and outdoor exposure to the harmful emissions released by solid fuel combustion. Use of traditional stoves can also have a significant impact on deforestation and climate change. This dire situation creates a critical need for cookstoves that significantly and verifiably reduce fuel use and emissions in order to reach protective levels for human health and the environment. Additionally, advances in the scientific equipment needed to measure and monitor stove fuel use and emissions have not kept pace with the significant need within the industry. While several testing centers in the developed world may have hundred thousand-dollar emissions testing systems, organizations in the field have had little more than a thermometer, a scale, and subjective observations to quantify the performance of stove designs. There is an urgent need for easy-to-use, inexpensive, accurate, and robust stove testing equipment for use by laboratory and field researchers around the world. ASAT and their research partner, Aprovecho Research Center (ARC), have over thirty years of experience addressing these two needs, improved cookstoves and emissions monitoring equipment, with expertise spanning the full spectrum of development from conceptual design to product manufacturing and dissemination. This includes: 1) research, design, and verification of clean biomass cookstove technology and emissions monitoring equipment; 2) mass production of quality-controlled stove and emissions equipment at levels scalable to meet global demand; and 3) global distribution through a variety of channels and partners. ARC has been instrumental in designing and improving more than 100 stove designs over the past thirty years. In the last four years, ASAT and ARC have played a key role in the production and sales of over 200,000 improved stoves in the developed and developing world. The ARC-designed emissions equipment is currently used by researchers in laboratories and field studies on five continents. During Phase I of the DOE STTR grant, ASAT and ARC worked together to apply their wealth of product development experience towards creating the next generation of improved cookstoves and emissions monitoring equipment. Highlights of Phase I for the biomass cookstove project include 1) the development of several new stove technologies that reached the DOE 50/90 benchmark; 2) fabrication of new stove prototypes by ASATs manufacturing partner, Shengzhou Stove Manufacturing (SSM); 3) field testing of prototype stoves with consumers in Puerto Rico and the US; and 4) the selection of three stove prototypes for further development and commercialization during Phase II. Highlights of Phase I for the emissions monitoring equipment project include: 1) creation of a new emissions monitoring equipment product, the Laboratory Emissions Monitoring System (LEMS 2) the addition of gravimetric PM measurements to the stove testing systems to meet International Standards Organization criteria; 3) the addition of a CO{sub 2} sensor and wireless 3G capability to the IAP Meter; and 4) and the improvement of sensors and signal quality on all systems. Twelve Regional Testing and Knowledge Centers purchased this equipment during the Phase I project period.

HATFIELD, MICHAEL; Still, Dean

2013-04-15T23:59:59.000Z

432

Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins  

SciTech Connect (OSTI)

Highlights: Overexpression of Ran in pancreatic cancer was correlated with histological grade. Downregulation of Ran could induce cell apoptosis and inhibit cell proliferation. The effects were mediated by cell cycle proteins, Survivin and cleaved Caspase-3. -- Abstract: Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3.

Deng, Lin [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China) [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China); Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xian, Shaanxi 710038 (China); Lu, Yuanyuan; Zhao, Xiaodi; Sun, Yi; Shi, Yongquan; Fan, Hongwei; Liu, Changhao; Zhou, Jinfeng; Nie, Yongzhan; Wu, Kaichun [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China); Fan, Daiming, E-mail: daimingfan@fmmu.edu.cn [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China); Guo, Xuegang, E-mail: xuegangguo@126.com [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China)] [State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi 710032 (China)

2013-10-18T23:59:59.000Z

433

Sandia technology & entrepreneurs improve Lasik  

SciTech Connect (OSTI)

Former Sandian Dan Neal started his company, WaveFront Sciences, based on wavefront sensing metrology technologies licensed from Sandia National Laboratories and by taking advantage of its Entrepreneurial Separation to Transfer Technology (ESTT) program. Abbott Medical Optics since acquired WaveFront and estimates that one million patients have improved the quality of their vision thanks to its products. ESTT is a valuable tool which allows Sandia to transfer technology to the private sector and Sandia employees to leave the Labs in order to start up new technology companies or help expand existing companies.

Neal, Dan; Turner, Tim

2013-11-21T23:59:59.000Z

434

Sandia technology & entrepreneurs improve Lasik  

ScienceCinema (OSTI)

Former Sandian Dan Neal started his company, WaveFront Sciences, based on wavefront sensing metrology technologies licensed from Sandia National Laboratories and by taking advantage of its Entrepreneurial Separation to Transfer Technology (ESTT) program. Abbott Medical Optics since acquired WaveFront and estimates that one million patients have improved the quality of their vision thanks to its products. ESTT is a valuable tool which allows Sandia to transfer technology to the private sector and Sandia employees to leave the Labs in order to start up new technology companies or help expand existing companies.

Neal, Dan; Turner, Tim

2014-02-26T23:59:59.000Z

435

Improving Energy Efficiency of Auxiliaries  

SciTech Connect (OSTI)

The summaries of this report are: Economics Ultimately Dictates Direction; Electric Auxiliaries Provide Solid Benefits. The Impact on Vehicle Architecture Will be Important; Integrated Generators With Combined With Turbo Generators Can Meet the Electrical Demands of Electric Auxiliaries; Implementation Will Follow Automotive 42V Transition; Availability of Low Cost Hardware Will Slow Implementation; Industry Leadership and Cooperation Needed; Standards and Safety Protocols Will be Important. Government Can Play an Important Role in Expediting: Funding Technical Development; Incentives for Improving Fuel Economy; Developing Standards, Allowing Economy of Scale; and Providing Safety Guidelines.

Carl T. Vuk

2001-12-12T23:59:59.000Z

436

Superalloy material with improved weldability  

DOE Patents [OSTI]

A fusion weldable superalloy containing 0.005-0.5 wt. % scandium. In one embodiment, the superalloy may have a composition similar to IN-939 alloy, but having added scandium and having only 0.005-0.040 wt. % zirconium. A gas turbine component may be formed by an investment casting of such a scandium-containing superalloy, and may include a fusion weld repaired area. A scandium-containing nickel-based superalloy coated with an MCrAlY bond coat will have improved cyclic oxidation resistance due to the sulfur-gettering effect of the scandium.

Allen, David B.; Wagner, Gregg P.; Seth, Brij B.

2004-02-24T23:59:59.000Z

437

Radio frequency detection assembly and method for detecting radio frequencies  

DOE Patents [OSTI]

A radio frequency detection assembly is described and which includes a radio frequency detector which detects a radio frequency emission produced by a radio frequency emitter from a given location which is remote relative to the radio frequency detector; a location assembly electrically coupled with the radio frequency detector and which is operable to estimate the location of the radio frequency emitter from the radio frequency emission which has been received; and a radio frequency transmitter electrically coupled with the radio frequency detector and the location assembly, and which transmits a radio frequency signal which reports the presence of the radio frequency emitter.

Cown, Steven H. (Rigby, ID); Derr, Kurt Warren (Idaho Falls, ID)

2010-03-16T23:59:59.000Z

438

Complementarity between collider, direct detection, and indirect detection experiments  

E-Print Network [OSTI]

We examine the capabilities of planned direct detection, indirect detection, and collider experiments in exploring the 19-parameter p(henomenological)MSSM, focusing on the complementarity between the different search techniques. In particular, we consider dark matter searches at the 7, 8 (and eventually 14) TeV LHC, \\Fermi, CTA, IceCube/DeepCore, and LZ. We see that the search sensitivities depend strongly on the WIMP mass and annihilation mechanism, with the result that different search techniques explore orthogonal territory. We also show that advances in each technique are necessary to fully explore the space of Supersymmetric WIMPs.

Matthew Cahill-Rowley

2014-11-12T23:59:59.000Z

439

[CANCER RESEARCH 64, 53905397, August 1, 2004] Effective Gene-Viral Therapy for Telomerase-Positive Cancers by Selective  

E-Print Network [OSTI]

-Positive Cancers by Selective Replicative-Competent Adenovirus Combining with Endostatin Gene Qi Zhang,1 Mingming

Tian, Weidong

440

doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER  

E-Print Network [OSTI]

doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

Brenner, David Jonathan

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one  

E-Print Network [OSTI]

Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17?-estradiol. An established cancer model was used

442

Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells  

E-Print Network [OSTI]

Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

Wahl, Geoffrey M.

443

Enzyme-free Detection of Hydrogen Peroxide from Cerium Oxide Nanoparticles Immobilized on Poly(4-vinylpyridine) Self-Assembled Monolayers  

SciTech Connect (OSTI)

A single layer of oxygen-deficient cerium oxide nanoparticles (CNPs) are immobilized on microscopic glass slide using poly(4-vinylpyridine) (PVP) self-assembled monolayers (SAMs). A specific colorimetric property of CNPs when reacted with hydrogen peroxide allows for the direct, single-step peroxide detection which can be used in medical diagnosis and explosives detection. Multiple PVP-CNP immobilized layers improve sensitivity of detection and the sensor can be regenerated for reuse.

Gaynor, James D.; Karakoti, Ajay S.; Inerbaev, Talgat; Sanghavi, Shail P.; Nachimuthu, Ponnusamy; Shutthanandan, V.; Seal, Sudipta; Thevuthasan, Suntharampillai

2013-05-02T23:59:59.000Z

444

Unexpected, Stable Form of Uranium Detected | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Unexpected, Stable Form of Uranium Detected Unexpected, Stable Form of Uranium Detected Insights on underappreciated reaction could shed light on environmental cleanup options...

445

Detection of the internal corrosion in pipeline  

E-Print Network [OSTI]

Detection of the internal corrosion in pipeline. Hyeonbae Kang. In this talk I will explain our new methods to detect internal corrosions in pipelines.

2006-10-17T23:59:59.000Z

446

Chemistry for Measurement and Detection Science  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry for Measurement and Detection Science Chemistry for Measurement and Detection Science Research into alternative forms of energy, especially energy security, is one of the...

447

Accounting for Incomplete Species Detection in Fish Community Monitoring  

SciTech Connect (OSTI)

Riverine fish assemblages are heterogeneous and very difficult to characterize with a one-size-fits-all approach to sampling. Furthermore, detecting changes in fish assemblages over time requires accounting for variation in sampling designs. We present a modeling approach that permits heterogeneous sampling by accounting for site and sampling covariates (including method) in a model-based framework for estimation (versus a sampling-based framework). We snorkeled during three surveys and electrofished during a single survey in suite of delineated habitats stratified by reach types. We developed single-species occupancy models to determine covariates influencing patch occupancy and species detection probabilities whereas community occupancy models estimated species richness in light of incomplete detections. For most species, information-theoretic criteria showed higher support for models that included patch size and reach as covariates of occupancy. In addition, models including patch size and sampling method as covariates of detection probabilities also had higher support. Detection probability estimates for snorkeling surveys were higher for larger non-benthic species whereas electrofishing was more effective at detecting smaller benthic species. The number of sites and sampling occasions required to accurately estimate occupancy varied among fish species. For rare benthic species, our results suggested that higher number of occasions, and especially the addition of electrofishing, may be required to improve detection probabilities and obtain accurate occupancy estimates. Community models suggested that richness was 41% higher than the number of species actually observed and the addition of an electrofishing survey increased estimated richness by 13%. These results can be useful to future fish assemblage monitoring efforts by informing sampling designs, such as site selection (e.g. stratifying based on patch size) and determining effort required (e.g. number of sites versus occasions).

McManamay, Ryan A [ORNL] [ORNL; Orth, Dr. Donald J [Virginia Polytechnic Institute and State University] [Virginia Polytechnic Institute and State University; Jager, Yetta [ORNL] [ORNL

2013-01-01T23:59:59.000Z

448

GMTI radar minimum detectable velocity.  

SciTech Connect (OSTI)

Minimum detectable velocity (MDV) is a fundamental consideration for the design, implementation, and exploitation of ground moving-target indication (GMTI) radar imaging modes. All single-phase-center air-to-ground radars are characterized by an MDV, or a minimum radial velocity below which motion of a discrete nonstationary target is indistinguishable from the relative motion between the platform and the ground. Targets with radial velocities less than MDV are typically overwhelmed by endoclutter ground returns, and are thus not generally detectable. Targets with radial velocities greater than MDV typically produce distinct returns falling outside of the endoclutter ground returns, and are thus generally discernible using straightforward detection algorithms. This document provides a straightforward derivation of MDV for an air-to-ground single-phase-center GMTI radar operating in an arbitrary geometry.

Richards, John Alfred

2011-04-01T23:59:59.000Z

449

Detecting Density Variations and Nanovoids  

SciTech Connect (OSTI)

A combination of simulated and experimental data has been used to investigate the size range of nanovoids that can be detected in atom probe tomography data. Simulated atom probe tomography data have revealed that nanovoids as small as 1 nm in diameter can be detected in atom probe tomography data with the use of iso-density surfaces. Iso-density surfaces may be used to quantify the size, morphology and number density of nanovoids and other variations in density in atom probe tomography data. Experimental data from an aluminum-yttrium-iron metallic glass ribbon have revealed the effectiveness of this approach. Combining iso-density surfaces with atom maps also permits the segregation of solute to the nanovoids to be investigated. Field ion microscopy and thin section atom maps have also been used to detect pores and larger voids.

Miller, Michael K [ORNL; Longstreth-Spoor, L. [Washington University, St. Louis; Kelton, K. F. [Washington University, St. Louis

2011-01-01T23:59:59.000Z

450

NON-INVASIVE OPTICAL DETECTION OF EPITHELIAL CANCER USING OBLIQUE INCIDENCE DIFFUSE REFLECTANCE SPECTROSCOPY  

E-Print Network [OSTI]

-pigmented lesions...................... 50 25 Results of the testing dataset for the non-pigmented lesions ..................... 51 26 Absorption coefficient spectra of common nevi, dysplastic nevi and melanoma... of abnormal cells that can only be seen by 5 histologic analysis and not through the endoscope. The current recommendation for patients who have a stable diagnosis of negative for dysplasia, confirmed by two endoscopic biopsy surveillance procedures...

Garcia-Uribe, Alejandro

2010-01-16T23:59:59.000Z

451

Ultra-low field MRI of prostate cancer using SQUID detection  

E-Print Network [OSTI]

amounts of deionized (DI) water mixed with heavy water.Heavy water is water made with the hydrogen isotopeDI water in each vial. Heavy water makes up the balance. C:

Busch, Sarah Elizabeth

2011-01-01T23:59:59.000Z

452

Autofluorescence detection and imaging of bladder cancer realized through a cystoscope  

DOE Patents [OSTI]

Near infrared imaging using elastic light scattering and tissue autofluorescence and utilizing interior examination techniques and equipment are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and/or tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

Demos, Stavros G. (Livermore, CA); deVere White, Ralph W. (Sacramento, CA)

2007-08-14T23:59:59.000Z

453

QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells  

E-Print Network [OSTI]

diode laser absorption spectroscopy (TDLAS) using a continuous wave, thermoelectrically cooled quantum cascade laser (QCL) and a 100-m astigmatic Herriot cell. A 2f-wave- length modulation spectroscopy

454

Investigation of infrared Fourier-Transform spectroscopy for oral cancer detection  

E-Print Network [OSTI]

tissue. Multiplicative signal correction (MSC), used during preprocessing, together with principal component analysis (PCA) showed a 90% sensitivity, 87% specificity and a false negative rate of . 1 0 between malignant and healthy/benign tissue types...

Cooney, Kevin Michael

1998-01-01T23:59:59.000Z

455

Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis  

E-Print Network [OSTI]

1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

Gerry, Arianna Aldridge

2011-01-01T23:59:59.000Z

456

E-Print Network 3.0 - approach sensitizes cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

sensitizes cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: approach sensitizes cancer Page: << < 1 2 3 4 5 > >> 1 Prostate cancer is the...

457

E-Print Network 3.0 - aggressive breast cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

breast cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: aggressive breast cancer Page: << < 1 2 3 4 5 > >> 1 Radiogenic Breast Cancer by...

458

E-Print Network 3.0 - algebraic cancer equation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer equation Search Powered by Explorit Topic List Advanced Search Sample search results for: algebraic cancer equation Page: << < 1 2 3 4 5 > >> 1 Cancer Treatment Using...

459

E-Print Network 3.0 - aggressive ovarian cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ovarian cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: aggressive ovarian cancer Page: << < 1 2 3 4 5 > >> 1 Biomarker for Ovarian Cancer...

460

E-Print Network 3.0 - aneuploid prostate cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

prostate cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: aneuploid prostate cancer Page: << < 1 2 3 4 5 > >> 1 Advanced Search Cancer...

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

E-Print Network 3.0 - advanced hypopharyngeal cancer Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: advanced hypopharyngeal cancer Page: << < 1 2 3 4 5 > >> 1 Eur J Cancer. Author manuscript...

462

An approach for improving Fault-Tolerance in Automotive Modular Embedded Software*  

E-Print Network [OSTI]

An approach for improving Fault-Tolerance in Automotive Modular Embedded Software* * This work has transportation research programme PREDIT) focused on robustness of executive software in critical automotive.killijian}@laas.fr Abstract Error detection and error recovery mechanism must be carefully selected in automotive embedded

Paris-Sud XI, Université de

463

Improving Life through Science and Technology Texas AgriLife Research  

E-Print Network [OSTI]

into water Improve agricultural and urban water use efficiency Address Storm Water issues · Investments and Quantity ($4M) Detect and model water contaminants Develop management practices to reduce loadings 0.5M acre-feet/year of water from Edwards Aquifer Developed preventative measures for golden algae

464

Ultrahigh Energy Cosmic Rays Detection  

E-Print Network [OSTI]

The paper describes methods used for the detection of cosmic rays with energies above 10^18 eV (UHECR, UltraHigh Energy Cosmic Rays). It had been anticipated there would be a cutoff in the energy spectrum of primary cosmic rays around 3 10^19 eV induced by their interaction with the 2.7 K primordial photons. This has become known as the GZK cutoff. However, several showers have been detected with estimated primary energy exceeding this limit.

Carla Aramo

2005-09-06T23:59:59.000Z

465

Detecting Botnets Through Log Correlation  

E-Print Network [OSTI]

Botnets, which consist of thousands of compromised machines, can cause significant threats to other systems by launching Distributed Denial of Service (SSoS) attacks, keylogging, and backdoors. In response to these threats, new effective techniques are needed to detect the presence of botnets. In this paper, we have used an interception technique to monitor Windows Application Programming Interface (API) functions calls made by communication applications and store these calls with their arguments in log files. Our algorithm detects botnets based on monitoring abnormal activity by correlating the changes in log file sizes from different hosts.

Al-Hammadi, Yousof

2010-01-01T23:59:59.000Z

466

Breast Density and Cancer | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

467

Investigation into taxane resistant breast cancer  

E-Print Network [OSTI]

One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

Kenicer, Juliet Elisabeth Margaret

2011-11-25T23:59:59.000Z

468

Micro and nanotechnology for cancer treatment  

E-Print Network [OSTI]

Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

Ullal, Adeeti (Adeeti Vedantham)

2013-01-01T23:59:59.000Z

469

Regulatory roles of endothelial cells in cancer  

E-Print Network [OSTI]

This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

Franses, Joseph W. (Joseph Wang)

2011-01-01T23:59:59.000Z

470

Evaluation of National Seismograph Network detection capabilities. Annual report, July 1994--July 1995: Volume 1  

SciTech Connect (OSTI)

This first annual report presents detection thresholds and probabilities, and location error ellipse projects for the United States National Seismic Network (USNSN) with and without cooperative stations in the eastern US. Network simulation methods are used with spectral noise levels at stations to simulate the processes of excitation, propagation, detection, and processing of seismic phases. USNSN alone should be capable of detecting 4 or more P waves for shallow crustal earthquakes in nearly all the eastern and central US at magnitude 3.8 level. When cooperative stations are added, the network should be able to detect 4 or more P waves from events 0.2 to 0.3 magnitude units lower. Planned expansion of USNSN and cooperative stations should improve detection levels by an additional 0.2-0.3 magnitudes units in many areas. Location uncertainties for USNSN can be improved by adding real-time cooperative stations. Median error ellipses for magnitude 4.5 earthquakes depend strongly on location, but uncertainties should be less than 100 km{sup 2} in the central US and degrade to 200 km{sup 2} or more offshore and sosuth and north of the international boundaries. Close cooperation with the Canadian National Network should substantially improve detection thresholds and location uncertainties along the Canadian border.

McLaughlin, K.L.; Bennett, T.J. [S-Cubed, La Jolla, CA (United States)

1996-03-01T23:59:59.000Z

471

The Role of Spectroscopy Versus Detection for Border Security  

SciTech Connect (OSTI)

Countries around the world are deploying radiation portal monitor (RPM) systems and other radiation detection instrumentation to interdict the illegal shipment of radioactive material crossing international borders. These efforts include deployments in the U.S. and in a number of other countries by governments and international organizations. Because of their high efficiency for gamma-ray detection, most deployed RPM systems are based on plastic scintillators. Such systems, however, are largely non-spectroscopic in capability. Fully capable spectroscopic portal monitor systems are undergoing engineering development for deployment in the future. The ability to identify the detected radionuclides may allow improved operational handling of radiation alarms, particularly those arising from the normal cargo stream of naturally occurring radioactive material, commercial radioactive sources, and individuals treated with medical radiopharmaceuticals. The goal for improved RPM systems is to increase the sensitivity to threats while reducing the impact that nuisance alarms have on operations. This paper considers the roles for spectroscopic and non-spectroscopic systems for safeguards and border security.

Kouzes, Richard T.; Ely, James H.

2008-06-15T23:59:59.000Z

472

Efficiency improved turboprop. Technical memo  

SciTech Connect (OSTI)

Renewed attention has been focused on the efficiency of aircraft propulsion as the cost of fuel has risen. Studies conducted by NASA (1) to obtain fuel efficient aircraft have considered relatively highly-loaded turbo-prop systems. The disc loadings of these propellers are as much as four times higher than those on present turboprop aircraft. The higher disc loadings result in greater slipstream swirl and higher energy losses. Of primary importance is the radial distribution of the energy losses across the slipstream due to the tangential and axial velocities. This study presents the results of analysis defining the various sources of energy loss resulting from a swirling slipstream downstream of a propeller. Experimental data are presented demonstrating the presence of such losses and a propeller configuration discussed which offers improved propulsive performance when relatively highly-loaded propellers are employed.

Gearhart, W.S.

1982-06-10T23:59:59.000Z

473

Recent performance improvements on FXR  

SciTech Connect (OSTI)

The FXR machine is a nominal 4-kA, 20-MeV, linear-induction, electron accelerator for flash radiography at LLNL. The machine met its baseline requirements in March 1982. Since then, the performance has been greatly improved. We have achieved stable and repeatable beam acceleration and transport, with over 80% transmission to the tungsten bremsstrahlung target located some 35 m downstream. For best stability, external-beam steering has been eliminated almost entirely. We regularly produce over 500 Roentgen at 1 m from the target (TLD measurement), with a radiographic spot size of 3 to 5 mm. Present efforts are directed towards the development of a 4-kA tune, working interactively with particle-field and beam transport code models. A remaining uncertainty is the possible onset of RF instabilities at the higher current levels.

Kulke, B.; Kihara, R.

1983-01-01T23:59:59.000Z

474

Data quality improvements for FAA  

SciTech Connect (OSTI)

Effective communication among air safety professionals is only as good as the information being communicated. Data sharing cannot be effective unless the data are relevant to aviation safety problems, and decisions based on faulty data are likely to be invalid. The validity of aviation safety data depends on satisfying two primary characteristics. Data must accurately represent or conform to the real world (conformance), and it must be relevant or useful to addressing the problems at hand (utility). The FAA, in efforts to implement the Safety Performance Analysis System (SPAS), identified significant problems in the quality of the data which SPAS and FAA air safety professionals would use in defining the state of aviation safety in the US. These finding were reinforced by Department of Transportation Inspector General and General Accounting Office investigations into FAA surveillance of air transport operations. Many recent efforts to improve data quality have been centered on technological solutions to the problems. They concentrate on reducing errors in the data (conformance), but they cannot adequately address the relationship of data to need (utility). Sandia National Laboratories, working with the FAA`s Airport and Aircraft Safety Research and Development Division and the Flight Standards Service, has been involved in four programs to assist FAA in addressing their data quality problems. The Sandia approach has been data-driven rather than technology-driven. In other words, the focus has been on first establishing the data requirements by analyzing the FAA`s surveillance and decision-making processes. This process analysis looked at both the data requirements and the methods used to gather the data in order to address both the conformance and utility problems inherent in existing FAA data systems. This paper discusses Sandia`s data quality programs and their potential improvements to the safety analysis processes and surveillance programs of the FAA.

Perry, R.; Marlman, K.; Olson, D.; Werner, P.

1997-09-01T23:59:59.000Z

475

detection  

National Nuclear Security Administration (NNSA)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNationalRestart of the Review of theOFFICE OF CIVILAMENDMENT20/%2A en Design

476

Ionizing Radiation Promotes Migration and Invasion of Cancer Cells Through Transforming Growth Factor-Beta-Mediated Epithelial-Mesenchymal Transition  

SciTech Connect (OSTI)

Purpose: To examine whether ionizing radiation enhances the migratory and invasive abilities of cancer cells through transforming growth factor (TGF-{beta})-mediated epithelial-mesenchymal transition (EMT). Methods and Materials: Six cancer cell lines originating from different human organs were irradiated by {sup 60}Co {gamma}-ray at a total dose of 2 Gy, and the changes associated with EMT, including morphology, EMT markers, migration and invasion, were observed by microscope, Western blot, immunofluorescence, scratch assay, and transwell chamber assay, respectively. Then the protein levels of TGF-{beta} in these cancer cells were detected by enzyme-linked immunosorbent assay, and the role of TGF-{beta} signaling pathway in the effect of ionizing radiation on EMT was investigate by using the specific inhibitor SB431542. Results: After irradiation with {gamma}-ray at a total dose of 2 Gy, cancer cells presented the mesenchymal phenotype, and compared with the sham-irradiation group the expression of epithelial markers was decreased and of mesenchymal markers was increased, the migratory and invasive capabilities were strengthened, and the protein levels of TGF-{beta} were enhanced. Furthermore, events associated with EMT induced by IR in A549 could be reversed through inhibition of TGF-{beta} signaling. Conclusions: These results suggest that EMT mediated by TGF-{beta} plays a critical role in IR-induced enhancing of migratory and invasive capabilities in cancer cells.

Zhou Yongchun [Department of Radiation Oncology, Xijing Hospital Fourth Military Medical University, Xi'an (China); Department of Radiation Medicine, College of Preventive Medicine, Xijing Hospital Fourth Military Medical University, Xi'an (China); Liu Junye; Li Jing; Zhang Jie [Department of Radiation Medicine, College of Preventive Medicine, Xijing Hospital Fourth Military Medical University, Xi'an (China); Xu Yuqiao [Department of Pathology, Xijing Hospital Fourth Military Medical University, Xi'an (China); Zhang Huawei; Qiu Lianbo; Ding Guirong [Department of Radiation Medicine, College of Preventive Medicine, Xijing Hospital Fourth Military Medical University, Xi'an (China); Su Xiaoming [Department of Radiation Oncology, 306th Hospital of PLA, Beijing (China); Mei Shi [Department of Radiation Oncology, Xijing Hospital Fourth Military Medical University, Xi'an (China); Guo Guozhen, E-mail: guozhenguo@hotmail.com [Department of Radiation Medicine, College of Preventive Medicine, Xijing Hospital Fourth Military Medical University, Xi'an (China)

2011-12-01T23:59:59.000Z

477

Anomalous change detection in imagery  

DOE Patents [OSTI]

A distribution-based anomaly detection platform is described that identifies a non-flat background that is specified in terms of the distribution of the data. A resampling approach is also disclosed employing scrambled resampling of the original data with one class specified by the data and the other by the explicit distribution, and solving using binary classification.

Theiler, James P. (Los Alamos, NM); Perkins, Simon J. (Santa Fe, NM)

2011-05-31T23:59:59.000Z

478

Image Mining: Detecting Deforestation Patterns  

E-Print Network [OSTI]

54 Chapter IV Image Mining: Detecting Deforestation Patterns Through Satellites Marcelino Pereira to analyze satellite images and extract knowledge from this kind of data. The Amazonia deforestation problem of change on deforested areas of Amazonia. The purpose of the authors is to present relevant technologies

Camara, Gilberto

479

Detection of explosives in soils  

DOE Patents [OSTI]

An apparatus and method for detecting explosive-indicating compounds in subsurface soil. The apparatus has a probe with an adsorbent material on some portion of its surface that can be placed into soil beneath the ground surface, where the adsorbent material can adsorb at least one explosive-indicating compound. The apparatus additional has the capability to desorb the explosive-indicating compound through heating or solvent extraction. A diagnostic instrument attached to the probe detects the desorbed explosive-indicating compound. In the method for detecting explosive-indicating compounds in soil, the sampling probe with an adsorbent material on at least some portion of a surface of the sampling probe is inserted into the soil to contact the adsorbent material with the soil. The explosive-indicating compounds are then desorbed and transferred as either a liquid or gas sample to a diagnostic tool for analysis. The resulting gas or liquid sample is analyzed using at least one diagnostic tool selected from the group consisting of an ion-mobility spectrometer, a gas chromatograph, a high performance liquid chromatograph, a capillary electrophoresis chromatograph, a mass spectrometer, a Fourier-transform infrared spectrometer and a Raman spectrometer to detect the presence of explosive-indicating compounds.

Chambers, William B. (Edgewood, NM); Rodacy, Philip J. (Albuquerque, NM); Phelan, James M. (Bosque Farms, NM); Woodfin, Ronald L. (Sandia Park, NM)

2002-01-01T23:59:59.000Z

480

Costeffective Outbreak Detection in Networks  

E-Print Network [OSTI]

on how contaminants spread in the network Problem posed by US Environmental Protection Agency S On which nodes should we place sensors to efficiently detect the all possible contaminations? S #12 Given a graph G(V,E) and a budget B for sensors and data on how contaminations spread over the network

Yang, Qiang

Note: This page contains sample records for the topic "improving cancer detection" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Observational Study Designs for Comparative Effectiveness Research: An Alternative Approach to Close Evidence Gaps in Head-and-Neck Cancer  

SciTech Connect (OSTI)

Comparative effectiveness research (CER) has emerged as an approach to improve quality of care and patient outcomes while reducing healthcare costs by providing evidence to guide healthcare decisions. Randomized controlled trials (RCTs) have represented the ideal study design to support treatment decisions in head-and-neck (H and N) cancers. In RCTs, formal chance (randomization) determines treatment allocation, which prevents selection bias from distorting the measure of treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in H and N RCTs, which limits the validity of their results to the broader H and N cancer patient population seen in clinical practice. Randomized controlled trials often do not address other knowledge gaps in the management of H and N cancer, including treatment comparisons for rare types of H and N cancers, monitoring of rare or late toxicity events (eg, osteoradionecrosis), or in some instances an RCT is simply not feasible. Observational studies, or studies in which treatment allocation occurs independently of investigators' choice or randomization, may address several of these gaps in knowledge, thereby complementing the role of RCTs. This critical review discusses how observational CER studies complement RCTs in generating the evidence to inform healthcare decisions and improve the quality of care and outcomes of H and N cancer patients. Review topics include a balanced discussion about the strengths and limitations of both RCT and observational CER study designs; a brief description of design and analytic techniques to handle selection bias in observational studies; examples of observational studies that inform current clinical practices and management of H and N cancers; and suggestions for relevant CER questions that could be addressed by an observational study design.

Goulart, Bernardo H.L., E-mail: bhg@uw.edu [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Ramsey, Scott D. [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Parvathaneni, Upendra [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); University of Washington, Seattle, Washington (United States)

2014-01-01T23:59:59.000Z

482

Advanced fenestration systems for improved daylight performance  

E-Print Network [OSTI]

Systems for Improved Daylight Performance S. Selkowitz, E.S.Systems for Improved Daylight Performance S. Selkowitz, E.S.Introduction The use of daylight to replace or supplement

Selkowitz, S.; Lee, E.S.

1998-01-01T23:59:59.000Z

483

Nontoxic quantum dot research improves solar cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nontoxic quantum dot research improves solar cells Nontoxic quantum dot research improves solar cells Solar cells made with low-cost, nontoxic copper-based quantum dots can achieve...

484

Productivity Improvement of a Manual Assembly Line  

E-Print Network [OSTI]

The current project addresses the productivity improvement of a manual assembly line by making use of operations analysis in the framework of Lean production. A methodology is proposed that helps to improve the productivity of any production process...

Yerasi, Pranavi

2012-10-19T23:59:59.000Z

485

Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer  

SciTech Connect (OSTI)

Purpose: To assess the doseresponse relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched casecontrol study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation doseresponse relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear doseresponse relationship for risk of stomach cancer in long-term survivors of cervical cancer.

Kleinerman, Ruth A., E-mail: kleinerr@mail.nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Holowaty, Eric [Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario (Canada); Hall, Per [Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm (Sweden); Pukkala, Eero [Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki (Finland); Vaalavirta, Leila [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Stovall, Marilyn; Weathers, Rita [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kaijser, Magnus [Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm (Sweden); Andersson, Michael [Department of Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Storm, Hans [Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (Denmark); Joensuu, Heikki [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, Iowa (United States); and others

2013-08-01T23:59:59.000Z

486

ATLAS & Particle Detection The ATLAS Experiment  

E-Print Network [OSTI]

SCIPP ATLAS & Particle Detection The ATLAS Experiment and Particle Detection A.A. Grillo SCIPP - UCSC 1 #12;SCIPP ATLAS & Particle Detection A.A. Grillo What's Happening in this Bucolic Place? 2 Arial View of CERN and the Geneva Countryside #12;SCIPP ATLAS & Particle Detection A

California at Santa Cruz, University of

487

Noise canceling in-situ detection  

DOE Patents [OSTI]

Technologies applicable to noise canceling in-situ NMR detection and imaging are disclosed. An example noise canceling in-situ NMR detection apparatus may comprise one or more of a static magnetic field generator, an alternating magnetic field generator, an in-situ NMR detection device, an auxiliary noise detection device, and a computer.

Walsh, David O.

2014-08-26T23:59:59.000Z

488

Vehicle Fuel Economy Improvement through Thermoelectric Waste...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Recovery Vehicle Fuel Economy Improvement through Thermoelectric Waste Heat Recovery 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and Posters...

489

Secretary Richardson Accepts Recommendations for Improving Security...  

National Nuclear Security Administration (NNSA)

Secretary Richardson Accepts Recommendations for Improving Security at Nuclear Weapons Laboratories | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS...

490

Refractory Lining Material Improves Gasifer Performance  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

water GASIFICATION CHAMBER the ENERGY lab NATIONAL ENERGY TECHNOLOGY LABORATORY Technology Transfer Refractory Lining Material Improves Gasifier Performance Award Winning...

491

cDNA Microarray Analysis of Serially Sampled Cervical Cancer Specimens From Patients Treated With Thermochemoradiotherapy  

SciTech Connect (OSTI)

Purpose: To elucidate changes in gene expression after treatment with regional thermochemoradiotherapy in locally advanced squamous cell cervical cancer. Methods and Materials: Tru-Cut biopsy specimens were serially collected from 16 patients. Microarray gene expression levels before and 24 h after the first and second trimodality treatment sessions were compared. Pathway and network analyses were conducted by use of Ingenuity Pathways Analysis (IPA; Ingenuity Systems, Redwood City, CA). Single gene expressions were analyzed by quantitative real-time reverse transcription-polymerase chain reaction. Results: We detected 53 annotated genes that were differentially expressed after trimodality treatment. Central in the three top networks detected by IPA were interferon alfa, interferon beta, and interferon gamma receptor; nuclear factor kappaB; and tumor necrosis factor, respectively. These genes encode proteins that are important in regulation cell signaling, proliferation, gene expression, and immune stimulation. Biological processes over-represented among the 53 genes were fibrosis, tumorigenesis, and immune response. Conclusions: Microarrays showed minor changes in gene expression after thermochemoradiotherapy in locally advanced cervical cancer. We detected 53 differentially expressed genes, mainly involved in fibrosis, tumorigenesis, and immune response. A limitation with the use of serial biopsy specimens was low quality of ribonucleic acid from tumors that respond to highly effective therapy. Another 'key limitation' is timing of the post-treatment biopsy, because 24 h may be too late to adequately assess the impact of hyperthermia on gene expression.

Borkamo, Erling Dahl, E-mail: borkamo@gmail.co [Section of Oncology, Institute of Medicine, University of Bergen, Bergen (Norway); Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen (Norway); Schem, Baard-Christian [Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen (Norway); Fluge, Oystein; Bruland, Ove [Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen (Norway); Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen (Norway); Dahl, Olav; Mella, Olav [Section of Oncology, Institute of Medicine, University of Bergen, Bergen (Norway); Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen (Norway)

2009-12-01T23:59:59.000Z

492

Ris Energy Report 4 Efficiency improvements Introduction  

E-Print Network [OSTI]

END ULTIMATE MEANS END-USE TRADE LINE Figure 9: The energy chain with the three levels of potential, to South Africa where the coal is mined. The further up the chain that efficiency is improved, the greaterRisø Energy Report 4 Efficiency improvements 6 Introduction Energy efficiency can be improved

493

Morbidity of ischemic heart disease in early breast cancer 15-20 years after adjuvant radiotherapy  

SciTech Connect (OSTI)

The purpose of this study was to assess the cardiac side effects, primarily the occurrence of ischemic heart disease, in symptom-free patients with early breast cancer treated with radiotherapy. Thirty-seven survivors of a former randomized study of early breast cancer were examined. Twenty patients irradiated pre- or postoperatively for left sided disease (study group patients) were compared with 17 controls who were either treated for right sided disease, or were nonirradiated patients. Radiotherapy was randomized in the original study; either tangential field [sup 60]Co, or electron-therapy was delivered. Echocardiography and bicycle ergometry stress test with [sup 99m]Tc SestaMIBI myocardial perfusion scintigraphy were carried out and the patients' major risk factors for ischemic heart disease were also listed. Our results showed a significant difference between the scintigraphic findings of the two groups. Five of the 20 study group patients (25%), while none of the 17 controls exhibited some kind of significant defects on scintigraphy, indicating ischemic heart disease (p < 0.05). No deterioration in left ventricular systolic and/or diastolic function could be detected by echocardiography. Radiotherapy for left sided breast cancer with the mentioned treatment technique may present as an independent risk factor in the long-term development of ischemic heart disease, while left ventricular dysfunction could not be related to the previous irradiation. The authors emphasize the need to optimize adjuvant radiotherapy for early breast cancer by considering the dose both to the heart as well as the cancer. 39 refs., 4 tabs.

Gyenes, G.; Rutqvist, L.E. (Karolinksa Hospital, Stockholm (Sweden)); Fornander, T.; Carlens, P.

1994-03-30T23:59:59.000Z

494

Differences in serum concentrations of organochlorine compounds by occupational social class in pancreatic cancer  

SciTech Connect (OSTI)

Background: The relationships between social factors and body concentrations of environmental chemical agents are unknown in many human populations. Some chemical compounds may play an etiopathogenic role in pancreatic cancer. Objective: To analyze the relationships between occupational social class and serum concentrations of seven selected organochlorine compounds (OCs) in exocrine pancreatic cancer: dichlorodiphenyltrichloroethane (p,p'-DDT), dichlorodiphenyldichloroethene (p,p'-DDE), 3 polychlorinated biphenyls (PCBs), hexachlorobenzene, and {beta}-hexachlorocyclohexane. Methods: Incident cases of exocrine pancreatic cancer were prospectively identified, and interviewed face-to-face during hospital admission (n=135). Serum concentrations of OCs were analyzed by high-resolution gas chromatography with electron-capture detection. Social class was classified according to occupation. Results: Multivariate-adjusted concentrations of all seven compounds were higher in occupational social classes IV-V (the less affluent) than in classes I-II; they were higher as well in class III than in classes I-II for four compounds. Concentrations of six OCs were higher in manual workers than in non-manual workers (p<0.05 for PCBs). Social class explained statistically between 3.7% and 5.7% of the variability in concentrations of PCBs, and 2% or less variability in the other OCs. Conclusions: Concentrations of most OCs were higher in the less affluent occupational social classes. In pancreatic cancer the putative causal role of these persistent organic pollutants may not be independent of social class. There is a need to integrate evidence on the contribution of different social processes and environmental chemical exposures to the etiology of pancreatic and other cancers.

Porta, Miquel [Institut Municipal d'Investigacio Medica, Barcelona (Spain); Facultat de Medicina, Universitat Autonoma de Barcelona (Spain); CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain)], E-mail: mporta@imim.es; Bosch de Basea, Magda [Institut Municipal d'Investigacio Medica, Barcelona (Spain); CIBER en Epidemiologia y Salud Publica CIBERESP (Spain); Universitat Pompeu Fabra, Barcelona (Spain); Benavides, Fernando G. [CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain); Universitat Pompeu Fabra, Barcelona (Spain); Lopez, Tomas [Institut Municipal d'Investigacio Medica, Barcelona (Spain); CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain); Fernandez, Esteve [Universitat Pompeu Fabra, Barcelona (Spain); Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Barcelona (Spain); Marco, Esther [Department of Environmental Chemistry, Institute of Chemical and Environmental Research (IIQAB-CSIC), Barcelona (Spain); Alguacil, Juan [CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain); Universidad de Huelva (Spain); Grimalt, Joan O. [CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain); Department of Environmental Chemistry, Institute of Chemical and Environmental Research (IIQAB-CSIC), Barcelona (Spain); Puigdomenech, Elisa [Institut Municipal d'Investigacio Medica, Barcelona (Spain); Facultat de Medicina, Universitat Autonoma de Barcelona (Spain); CIBER en Epidemiologia y Salud Publica (CIBERESP) (Spain)

2008-11-15T23:59:59.000Z

495

Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition  

E-Print Network [OSTI]

model adjusted for age, sex, energy (nonfat and fat sources), height, weight, work-related physical. Affiliations of authors: From the Nutrition and Hormones Group, International Agency for Research on Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark (AO, A. Tjønneland); Institut National de la Santé et

Paris-Sud XI, Université de

496

Dana-Farber Cancer Institute About Dana-Farber Cancer Institute  

E-Print Network [OSTI]

;About the Jimmy Fund The Jimmy Fund raises vital funds to support adult and pediatric cancer care and research at Dana-Farber exclusively. Since 1948, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: · raised more than $948

Liu, Xiaole Shirley

497

Using Dashboards to Improve Energy and Comfort in Federal Buildings  

SciTech Connect (OSTI)

Federal agencies are taking many steps to improve the sustainability of their operations, including improving the energy efficiency of their buildings, promoting recycling and reuse of materials, encouraging carpooling and alternative transit schemes, and installing low flow water fixture units are just a few of the common examples. However, an often overlooked means of energy savings is to provide feedback to building users about their energy use through information dashboards connected to a building?s energy information system. An Energy Information System (EIS), broadly defined, is a package of performance monitoring software, data acquisition hardware, and communication systems that is used to collect, store, analyze, and display energy information. At a minimum, the EIS provides the whole-building energy-use information (Granderson 2009a). We define a ?dashboard? as a display and visualization tool that utilizes the EIS data and technology to provide critical information to users. This information can lead to actions resulting in energy savings, comfort improvements, efficient operations, and more. The tools to report analyzed information have existed in the information technology as business intelligence (Few 2006). The dashboard is distinguished from the EIS as a whole, which includes additional hardware and software components to collect and storage data, and analysis for resources and energy management (Granderson 2009b). EIS can be used for a variety of uses, including benchmarking, base-lining, anomaly detection, off-hours energy use evaluation, load shape optimization, energy rate analysis, retrofit and retro-commissioning savings (Granderson 2009a). The use of these EIS features depends on the specific users. For example, federal and other building managers may use anomaly detection to identify energy waste in a specific building, or to benchmark energy use in similar buildings to identify energy saving potential and reduce operational cost. There are several vendors of EIS technology that provide information on energy and other environmental variables in buildings.

Lawrence Berkeley National Laboratory; Marini, Kyle; Ghatikar, Girish; Diamond, Richard

2011-02-01T23:59:59.000Z

498

Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki  

E-Print Network [OSTI]

Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute & Finnish Institute, Helsinki, Finland Summary Metastatic cancer remains difficult to treat effectively and treatments

Hemminki, Akseli

499

E-Print Network 3.0 - advanced colon cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: advanced colon cancer Page: << < 1 2 3 4 5 > >> 1 The Cancer Risk Clinic Cancer Risk...

500

E-Print Network 3.0 - anal canal cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: anal canal cancer Page: << < 1 2 3 4 5 > >> 1 Cancer et infection VIH Cancer and HIV...