National Library of Energy BETA

Sample records for imaging antifungal drug

  1. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlONImaging Antifungal Drug

  2. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlONImaging Antifungal

  3. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdahoImagingImaging

  4. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlON OFMA!n!NEZ9,036,866Imaging

  5. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdahoImaging PrintIMGImaging

  6. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdahoImaging

  7. 1. (a) Why are DNA-targeted drugs largely used as anticancer agents and not as, say, antibacterial or antifungal agents?

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Homework 4 1. (a) Why are DNA-targeted drugs largely used as anticancer agents and not as, say, antibacterial or antifungal agents? (b) Provide an explanation for how anticancer drugs can-damaging drugs mentioned in Question 1). (b) However, some medicinal chemists believe that these compounds

  8. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Gilliam, Jacob T. (Norwalk, IA); Hunter-Cevera, Jennie (Elliott City, MD); Presnail, James K. (Avondale, PA); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2009-09-15

    The invention relates to antifungal compositions and methods for protecting a plant from a fungal pathogen. Compositions including antifungal polypeptides isolated from a fungal fermentation broth are provided.

  9. Imaging Antifungal Drug Molecules in Action using Soft X-Ray...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop...

  10. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlON OFMA!n!NEZ9,036,866 Site

  11. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlON OFMA!n!NEZ9,036,866

  12. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlON

  13. Image-based multivariate profiling of drug responses from single cells

    E-Print Network [OSTI]

    Cai, Long

    Image-based multivariate profiling of drug responses from single cells Lit-Hsin Loo, Lani F Wu are required for summarizing high- throughput, image-based drug screening data. Here we present a multivariate transform distributions of multi- dimensional, phenotypic measurements from single cells into multivariate

  14. Optimal drug release schedule for in-situ radiosensitization of image guided permanent prostate implants

    E-Print Network [OSTI]

    Sridhar, Srinivas

    of image guided 125 I prostate brachytherapy. Spacers used in permanent implants may be manufactured from such a constraint, is not known. This work determines the optimal elution schedules for 125 I prostate brachytherapy. The interaction between brachytherapy dose distributions and drug distribution around drug eluting spacers

  15. Non-radioactive molecular imaging of cancer drugs The overall goal of the research project performed in a collaboration between the University medical

    E-Print Network [OSTI]

    Twente, Universiteit

    Non-radioactive molecular imaging of cancer drugs The overall goal of the research project of Twente is to develop anti-cancer drugs primarily based on non-radioactive molecular imaging. This research will guide patient-tailored selection of drugs directed at the HER pathway, measure in vivo drug

  16. Isolation and characterization of potent antifungal strains of the Streptomyces violaceusniger clade active against Candida albicans

    E-Print Network [OSTI]

    Kang, Min J.; Strap, Janice L.; Crawford, Donald L.

    2010-01-01

    antifungal Streptomyces biocontrol agents isolated fromproduced by the biocontrol agent Streptomyces violaceusniger

  17. Antiarrhythmic Drugs

    E-Print Network [OSTI]

    Abbott, GW; Levi, R

    2012-01-01

    of beta blockers: from antianginal drugs to ligand-directedmechanisms of gating and drug block of sodium channels.Roden DM. Antiarrhythmic drugs: past, present and future. J

  18. Evotec has teamed up with the Harwell Imaging Partnership (HIP) to maximise the potential of their research into cancer treatment drugs

    E-Print Network [OSTI]

    of their research into cancer treatment drugs using the Science and Technology Facilities Council (STFC)'s Central@stfc.ac.uk Twitter: @STFC_B2B Using lasers to develop fluorescent anti-cancer drugs The challenge Some drug, but the efficiency of these drugs varies greatly. Treatments are often effective for a short while, but the disease

  19. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you notHeat Pumps Heat Pumpsfacility doe logo CH2M-WG logoImaging

  20. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdahoImaging Print The

  1. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdahoImaging Print

  2. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  3. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  4. Imaging Data Science | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHusseinSOLICWfATION/MODIFICATlONImaging AntifungalImaging

  5. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Ellanskaya, legal representative, Natalia (Kyiv, IL); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (Clive, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA); Ellanskaya, deceased, Irina (Kyiv, IL)

    2007-12-11

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  6. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Elleskaya, Irina (Kyiv, UA); Ellanskaya, legal representative; Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2010-08-10

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  7. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Elleskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2011-04-12

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  8. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Granger, IA); Dahlbacka, Glen (Oakland, CA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, TX); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2012-04-03

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  9. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Granger, IA); Crane, Virginia C. (Des Moines, IA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Gilliam, Jacob T. (Norwalk, IA); Hunter-Cevera, Jennie (Elliott City, MD); Presnail, James K. (Avondale, PA); Schepers, Eric J. (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2009-10-06

    The invention relates to compositions including amino acid sequences isolated from fungal fermentation broths and methods for protecting a plant from a pathogen, particularly a fungal pathogen.

  10. Orthopaedic Implant & Imaging Laboratory Our laboratory is dedicated to exploring the

    E-Print Network [OSTI]

    Berdichevsky, Victor

    on tissue biocompatibility Composite of polymetric, metallic and ceramic materials with drug loading coating with nanoceramic matrix for controlled drug release Molecular and Cellular Imaging PET/CT Imaging

  11. Exanthematous allergic drug reactions due to four chemically unrelated drugs

    E-Print Network [OSTI]

    Gupta, Ramji; Gupta, Sameer

    2008-01-01

    16. Lachgar T, Touil Y. The drug hypersensitivity syndromeW, Bircher A, Romano A et al. Drug provocation testing inthe diagnosis of drug hypersensitivity reactions: general

  12. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  13. Orphanet Berichtsreihe Orphan Drugs Datenerhebung

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Orphanet Berichtsreihe Orphan Drugs Datenerhebung Verzeichnis der in Europa zugelassenen Orphan Drugs Mit europäischer Orphan-Drug-Designation und europäischer Marktzulassung* Mit europäischer Marktzulassung* ohne vorherige Orphan-Drug-Designation *Zentrales Zulassungsverfahren der Europäischen

  14. "...powered bodies turn to commodities..." -stereolab Drugs and Drug Abuse

    E-Print Network [OSTI]

    Teissére, Jeremy Alden

    "...powered bodies turn to commodities..." - stereolab BIO 115 Fall, 2008 Drugs and Drug Abuse the current narratives surrounding drug use. In parallel, we will closely examine the putative mechanisms by which drugs act in the central nervous system ­ and also discuss how the action of these drugs has

  15. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Drug delivery Sustained Drug Release from Non-eroding Nanoporous Templates** Evin Gultepe, Dattatri drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug phosphate-buffered saline (PBS), which is commonly employed to simulate in vivo conditions for drug release

  16. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  17. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  18. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  19. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  20. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Fletcher, Robin

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  1. DRUG DISCOVERY AT PURDUE 2013-14

    E-Print Network [OSTI]

    Pittendrigh, Barry

    DRUG DISCOVERY AT PURDUE 2013-14 #12;PURDUE UNIVERSITY DRUG DISCOVERY 2 #12;PURDUE UNIVERSITY DRUG DISCOVERY 3 #12;PURDUE UNIVERSITY DRUG DISCOVERY 4 TABLE OF CONTENTS INTRODUCTION ..................................................................................................p. 8 ALPHABETICAL LIST OF DRUG DISCOVERY RESEARCHERS

  2. Copper(II) complexes with 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid: Syntheses, crystal structures and antifungal activities

    SciTech Connect (OSTI)

    Xiong, Pingping; Li, Jie; Bu, Huaiyu; Wei, Qing; Zhang, Ruolin; Chen, Sanping

    2014-07-01

    Reaction of Cu(II) with an asymmetric semi-rigid organic ligand 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid (HL), yielded five compounds, [Cu{sub 0.5}L]{sub n} (1), [Cu(HL){sub 2}Cl{sub 2}]{sub n} (2), [Cu(HL){sub 2}Cl{sub 2}(H{sub 2}O)] (3), [Cu(L){sub 2}(H{sub 2}O)]{sub n} (4) and [Cu(L)(phen)(HCO{sub 2})]{sub n} (5), which have been fully characterized by infrared spectroscopy, elemental analysis, and single-crystal X-ray diffraction. As for compounds 1, 2 and 5, Cu(II) is bridged through HL, Cl{sup -}, and formic acid, respectively, featuring 1D chain-structure. In compound 3, Cu(II) with hexahedral coordination sphere is assembled through hydrogen-bonding into 3D supramolecular framework. In compound 4, 1D chain units –Cu–O–Cu–O– are ligand-bridged into a 3D network. All compounds were tested on fungi (Fusarium graminearum, Altemaria solani, Macrophoma kawatsukai, Alternaria alternata and Colletotrichum gloeosporioides). Compound 1 exhibits a better antifungal effect compared to other compounds. An effect of structure on the antifungal activity has also been correlated. - Graphical abstract: Copper(II) compounds with 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid, were prepared, structurally characterized and investigated for antifungal activity. - Highlights: • The title compounds formed by thermodynamics and thermokinetics. • The five compounds show higher inhibition percentage than reactants. • The structure effect on the antifungal activity.

  3. Test Images

    E-Print Network [OSTI]

    Test Images. I hope to have a set of test images for the course soon. Some images are available now; some will have to wait until I can find another 100-200

  4. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26

    Stability 0 20 40 60 80 100 25 10 5 1 0.5 size? r 0 (?m) Fr action absor b ed in hum an (% ) Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 Solubility? Cs = 1.0 (?g/ml) Effect of micronization on intestinal absorption of poorly soluble drugs Peff... ?? permeability to human intestine? (cm/sec x 10 -4 ) 8 Effect of Solubility on intestinal absorption of poorly soluble drugs Cs (?g/ml) 0 5 10 15 50 Fr action absor b ed in hum an (% ) 0 20 40 60 80 100 Peff =5.0 Peff =3.0 Peff =1.0 Peff =0.5 Peff =0.1 r 0 = 1...

  5. Systems Theory for Pharmaceutical Drug Discovery

    E-Print Network [OSTI]

    Aswani, Anil Jayanti

    2010-01-01

    model to identify multiple drug targets which can be candidates for the traditional process of drug discovery.

  6. PHCL4003: Anti-infective drugs: Drugs that kill invaders -2015 Spring Course Co-Directors

    E-Print Network [OSTI]

    Marchant, Jonathan

    1 PHCL4003: Anti-infective drugs: Drugs that kill invaders - 2015 Spring Course Co to antimicrobial chemotherapy Jan. 26: 2. Principles of antibacterial drugs I: Drug targets and cytotoxicity Jan. 28: 3. Principles of antibacterial drugs II: Drug resistance Feb. 2: 4. Antibacterial drugs

  7. Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia

    E-Print Network [OSTI]

    Purdon, Patrick Lee

    It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging ...

  8. Image alignment

    DOE Patents [OSTI]

    Dowell, Larry Jonathan

    2014-04-22

    Disclosed is a method and device for aligning at least two digital images. An embodiment may use frequency-domain transforms of small tiles created from each image to identify substantially similar, "distinguishing" features within each of the images, and then align the images together based on the location of the distinguishing features. To accomplish this, an embodiment may create equal sized tile sub-images for each image. A "key" for each tile may be created by performing a frequency-domain transform calculation on each tile. A information-distance difference between each possible pair of tiles on each image may be calculated to identify distinguishing features. From analysis of the information-distance differences of the pairs of tiles, a subset of tiles with high discrimination metrics in relation to other tiles may be located for each image. The subset of distinguishing tiles for each image may then be compared to locate tiles with substantially similar keys and/or information-distance metrics to other tiles of other images. Once similar tiles are located for each image, the images may be aligned in relation to the identified similar tiles.

  9. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  10. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  11. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    pdf. Accessed February 2011. Medco. 2010 Drug Trend Report.www.drugtrend.com/art/drug_trend/pdf/DT_Report_2010.pdf.chronic myeloid leukaemia. Drugs. 2007;67(2): p. 299- April

  12. Prescription Drug List effective January 1, 2015

    E-Print Network [OSTI]

    Arnold, Jonathan

    1 Your 2015 Prescription Drug List effective January 1, 2015 Student Resources Traditional ThreeZIPcode. ·Lookuppossiblelower-costmedicationalternatives. ·Comparemedicationpricingandoptions. #12;2 Your Prescription Drug List This Prescription Drug List (PDL) outlines the most commonly prescribed medications for certain

  13. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  14. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  15. Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences

    E-Print Network [OSTI]

    Rosso, Paolo

    Drug-Drug Interaction Detection: A New Approach Based on Maximal Frequent Sequences Detecci´on de´armacos, extracci´on de relaciones, secuencias frecuentes maximales Abstract: In this paper, a new approach for Drug-Drug that contain Drug-Drug Interactions. Maximal Frequent Sequences define word sequences that are frequent

  16. Advances in lasers, optics, and imaging for the life sciences

    E-Print Network [OSTI]

    Heller, Eric

    Molecular Imaging Congress BioOpto Japan BioOpticsWorld.com "Invisible" molecules glow with new label- free possibilities for biomedical imaging, such as label- free mapping drug distributions and blood vessels on and off at 5 MHz. The spectrally filtered stimulation beam is detected by a large area photodiode

  17. Nanomedicine (Lond) . Author manuscript Cancer optical imaging using fluorescent nanoparticles

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ; medical imaging ; near-infrared ; photoacoustic ; phototherapy Developing imaging technologies in the drug development process very early in the laboratory, during the translation phase from in vitro to the acquisition of molecular information including Positron Emission Tomography (PET), Single photon emission

  18. Cancer optical imaging using fluorescent nanoparticles Developing imaging technologies and molecular probes that allow cancer detection at its

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Cancer optical imaging using fluorescent nanoparticles Developing imaging technologies in the drug development process very early in the laboratory, during the translation phase from in vitro to the acquisition of molecular information including Positron Emission Tomography (PET), Single photon emission

  19. Discovering the Targets of Drugs Via Computational

    E-Print Network [OSTI]

    Discovering the Targets of Drugs Via Computational Systems Biology* Published, JBC Papers in Press is empowering the study of drug action. Studies on biological effects of chemical com- pounds have increased of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy

  20. Drug-Target Interaction Predicates Combining Similarities

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Predicates DataSet Combining Similarities Collective Inference Collective Inference and Multi-Relational Learning for Drug­Target Interaction Prediction Shobeir Fakhraei1, Bert Huang1 and Lise Getoor1,2 Poly-pharmacology Drug Repurposing Drug-Target Interaction Network Studies

  1. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  2. An approach to drug delivery using novel carbohydrates to carry drugs

    E-Print Network [OSTI]

    Davis, Ben G.

    An approach to drug delivery using novel carbohydrates to carry drugs has recently been described of the cancer drug doxorubicin targeted to hepatocytes in a mouse liver tumour model. Known as the LEAPT step involves administering the rhamnose-capped pro-drug; the drug is activated in the target cell once

  3. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  4. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  5. Alcohol and Other Drugs -1 -Approved: 05/09/2014 Alcohol and Other Drugs

    E-Print Network [OSTI]

    Hammack, Richard

    Alcohol and Other Drugs - 1 - Approved: 05/09/2014 Alcohol and Other Drugs Policy Type: Board with the federal Drug Free Workplace Act of 1988, the federal Drug Free Schools and Communities Act of 1989, and the Commonwealth of Virginia's Policy on Alcohol and Other Drugs (AOD), it is the policy of Virginia Commonwealth

  6. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  7. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  8. Multimodality Image Fusion-Guided Procedures: Technique, Accuracy, and Applications

    SciTech Connect (OSTI)

    Abi-Jaoudeh, Nadine, E-mail: naj@mail.nih.gov [National Institutes of Health, Radiology and Imaging Sciences (United States); Kruecker, Jochen, E-mail: jochen.kruecker@philips.com [Philips Research North America (United States); Kadoury, Samuel, E-mail: samuel.kadoury@polymtl.ca [Ecole Polytechnique de Montreal, Department of Computer and Software Engineering, Institute of Biomedical Engineering (Canada); Kobeiter, Hicham, E-mail: hicham.kobeiter@gmail.com [CHU Henri Mondor, UPEC, Departments of Radiology and d'imagrie medicale (France); Venkatesan, Aradhana M., E-mail: VenkatesanA@cc.nih.gov; Levy, Elliot, E-mail: levyeb@cc.nih.gov; Wood, Bradford J., E-mail: bwood@cc.nih.gov [National Institutes of Health, Radiology and Imaging Sciences (United States)

    2012-10-15

    Personalized therapies play an increasingly critical role in cancer care: Image guidance with multimodality image fusion facilitates the targeting of specific tissue for tissue characterization and plays a role in drug discovery and optimization of tailored therapies. Positron-emission tomography (PET), magnetic resonance imaging (MRI), and contrast-enhanced computed tomography (CT) may offer additional information not otherwise available to the operator during minimally invasive image-guided procedures, such as biopsy and ablation. With use of multimodality image fusion for image-guided interventions, navigation with advanced modalities does not require the physical presence of the PET, MRI, or CT imaging system. Several commercially available methods of image-fusion and device navigation are reviewed along with an explanation of common tracking hardware and software. An overview of current clinical applications for multimodality navigation is provided.

  9. Imaging Scatterometry

    E-Print Network [OSTI]

    Madsen, Morten Hannibal

    2015-01-01

    We present an optical metrology system for characterization of topography of micro/nano-structures on a surface or embedded in a semi-transparent material. Based on the principles of scatterometry, where the intensity of scattered light is used as a 'fingerprint' to reconstruct a surface, this new imaging scatterometer can easily find areas of interest on the cm scale and measure multiple segments simultaneously. The imaging scatterometer measures structural features, such as height, width, and sidewall angle of a grating locally on few um2 areas with nm resolution. We demonstrate two imaging scatterometers, one built into an optical microscope and one in a split configuration. The two scatterometers are targeted characterization of mm2 and cm2 areas, respectively, and both setups are validated using nano-textured samples.

  10. Brain science, addiction and drugs

    E-Print Network [OSTI]

    Wiesner, Karoline

    Designing your future Page 7 Theme: Nanoscience and Quantum Information Exchanging keys in the Canaries Page:searchUniversity of Bristol · Research Review · Issue 10 · October 2005 research themes issue #12;Research themes 2005 Establishedresearchthemes Theme: Neuroscience Brain science, addiction and drugs Other established research themes

  11. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  12. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  13. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  14. Drug transport in brain via the cerebrospinal fluid

    E-Print Network [OSTI]

    Pardridge, William M

    2011-01-01

    diffusion. Drug transport into cerebrospinal fluid vs. brainDrug transport from blood to interstitial fluid (ISF) isDrug transport in brain via the cerebrospinal fluid William

  15. Nuclear Imaging | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Jefferson Lab's Radiation Detector and Imaging Group Members of Jefferson Lab's Radiation Detector & Medical Imaging Group design and build unique imaging devices based on...

  16. Predicting new molecular targets for known drugs

    E-Print Network [OSTI]

    Kaski, Samuel

    ARTICLES Predicting new molecular targets for known drugs Michael J. Keiser1,2 *, Vincent Setola3 drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug­target combinations exist, it would be useful to explore possible

  17. CMVO Drug Testing Program Reasonable Suspicion Testing

    E-Print Network [OSTI]

    Sin, Peter

    CMVO Drug Testing Program Reasonable Suspicion Testing CMVO Revised Suspicion Form (Revised 6/08) Guidelines for Reasonable Suspicion Drug and Alcohol Testing: A supervisor, trained in accordance with 49 CFR involved in an incident that requires drug/alcohol testing as set forth in 382.307. Remember: Reasonable

  18. Focus Article Open challenges in magnetic drug

    E-Print Network [OSTI]

    Shapiro, Benjamin

    Focus Article Open challenges in magnetic drug targeting Benjamin Shapiro,1,2 Sandip Kulkarni,1 Aleksander Nacev,3 Silvia Muro,1,4 Pavel Y. Stepanov3 and Irving N. Weinberg3 The principle of magnetic drug is that highlight- ing these challenges will help researchers translate magnetic drug targeting from a novel concept

  19. Drugs and Behavior (Psychology 320 Sec. 001)

    E-Print Network [OSTI]

    Hopfinger, Joseph B.

    1 Drugs and Behavior (Psychology 320 Sec. 001) Syllabus Example Text: Maisto, Galizio and Conners. Drug Use and Abuse. Harcourt Brace College Publishers. 2008, Fifth Edition. Prerequisites: This course of drugs of abuse. An overview of basic pharmacology and behavioral pharmacology will be provided followed

  20. Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse

    E-Print Network [OSTI]

    Henderson, Gideon

    Proctors' Memorandum on Drugs Misuse Guidelines from Proctors' Office on Dealing with Drugs Misuse The use of specified drugs is illegal within the UK, and is inimical to the University's primary objectives of the pursuit of academic study and research. The presence of drugs within the University

  1. Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative Loading Efficiency

    E-Print Network [OSTI]

    Cheng, Jianjun

    Dimeric Drug Polymeric Nanoparticles with Exceptionally High Drug Loading and Quantitative LoadingChampaign, Urbana, Illinois 61801, United States Key Laboratory of Smart Drug Delivery, Ministry of Education-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing

  2. Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug Discussions

    E-Print Network [OSTI]

    Dredze, Mark

    Experimenting with Drugs (and Topic Models): Multi-Dimensional Exploration of Recreational Drug of new recreational drugs and trends re- quires mining current information from non-traditional text components. The resulting model learns factors that correspond to drug type, delivery method (smoking

  3. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  4. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS (5/3/2013) Introduction Drugs have a successful history of use in treating diseases and are responsible for many medical advances over the past century. However, virtually every drug has side effects

  5. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws relating

  6. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, Glen A. (Los Alamos, NM)

    1999-01-01

    Radiation-hard, steady-state imaging bolometer. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas.

  7. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, G.A.

    1999-01-19

    Radiation-hard, steady-state imaging bolometer is disclosed. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas. 2 figs.

  8. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Drugs in Cinema: Separating the Myths from Reality PaulSUMMARY 7 (2000). DRUGS IN CINEMA policy has a significantviolence in film. DRUGS IN CINEMA III. HISTORY OF DRUG USE

  9. Vaginal mesh grafts and the Food and Drug Administration

    E-Print Network [OSTI]

    Ostergard, Donald R.

    2010-01-01

    and the Food and Drug Administration Donald R. Ostergardthe food and drug administration's (FDA) 510(k) process of

  10. Testing Drugs Versus Testing For Drug Use: Private Risk Management in the Shadow of the Criminal Law

    E-Print Network [OSTI]

    MacCoun, Robert J.

    2007-01-01

    Preface: The Varieties of Drug Control at the Dawn of thetbl.1.1. Id. See Peter Reuter, Drug Use Measures: What AreBetween Student Illicit Drug Use and School Drug-Testing

  11. RSNA 2002: Image Fusion Image Fusion

    E-Print Network [OSTI]

    Pelizzari, Charles A.

    RSNA 2002: Image Fusion Image Fusion: Introduction to the Technology Charles A. Pelizzari, Ph.D. Department of Radiation and Cellular Oncology The University of Chicago #12;RSNA 2002: Image Fusion "Fusion and limitations) ·Where do we need to go? (future directions) #12;RSNA 2002: Image Fusion Terminology

  12. Image Gallery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdaho NationalA pIlyaImage

  13. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non

  14. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug .98 in the case that the tested individual uses the drug) and 90% accurate in the case of a non it is known that 10% of the entire population uses this drug. You test someone and the test is positive. What

  15. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  16. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  17. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    drugs related to infertility treatment (for those plans thatloss treatments; infertility treatments; smoking cessationfor the treatment of sexual dysfunction and infertility). In

  18. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  19. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  20. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs

    E-Print Network [OSTI]

    Liu, Mei; Wu, Yonghui; Chen, Yukun; Sun, Jingchun; Zhao, Zhongming; Chen, Xue-wen; Matheny, Michael Edwin; Xu, Hua

    2012-06-19

    Abstract Objective Adverse drug reaction (ADR) is one of the major causes of failure in drug development. Severe ADRs that go undetected until the post-marketing phase of a drug often lead to patient morbidity. Accurate prediction of potential ADRs...

  1. Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM

    E-Print Network [OSTI]

    Drug Testing Notification Form RV 2 May 22, 2013 DRUG TESTING NOTIFICATION FORM Section 1: Employer testing collector. You are required to undergo urine drug testing as a condition of hiring. You must have of Collection: ___________________________ Date and time of Test* * For testing out side of Louisiana testing

  2. Sandia Energy - Advanced Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Imaging Home Transportation Energy Predictive Simulation of Engines Reacting Flow Experiments Advanced Imaging Advanced ImagingAshley Otero2015-10-30T01:47:37+00:00...

  3. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  4. Antiplatelet and Anticoagulant Drugs in Interventional Radiology

    SciTech Connect (OSTI)

    Altenburg, Alexander; Haage, Patrick, E-mail: patrick.haage@helios-kliniken.de [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany)

    2012-02-15

    In treating peripheral arterial disease, a profound knowledge of antiplatelet and anticoagulative drug therapy is helpful to assure a positive clinical outcome and to anticipate and avoid complications. Side effects and drug interactions may have fatal consequences for the patient, so interventionalists should be aware of these risks and able to control them. Aspirin remains the first-line agent for antiplatelet monotherapy, with clopidogrel added where dual antiplatelet therapy is required. In case of suspected antiplatelet drug resistance, the dose of clopidogrel may be doubled; prasugrel or ticagrelor may be used alternatively. Glycoprotein IIb/IIIa inhibitors (abciximab or eptifibatide) may help in cases of hypercoagulability or acute embolic complications. Desmopressin, tranexamic acid, or platelet infusions may be used to decrease antiplatelet drug effects in case of bleeding. Intraprocedurally, anticoagulant therapy treatment with unfractionated heparin (UFH) still is the means of choice, although low molecular-weight heparins (LMWH) are suitable, particularly for postinterventional treatment. Adaption of LMWH dose is often required in renal insufficiency, which is frequently found in elderly patients. Protamine sulphate is an effective antagonist for UFH; however, this effect is less for LMWH. Newer antithrombotic drugs, such as direct thrombin inhibitors or factor X inhibitors, have limited importance in periprocedural treatment, with the exception of treating patients with heparin-induced thrombocytopenia (HIT). Nevertheless, knowing pharmacologic properties of the newer drugs facilitate correct bridging of patients treated with such drugs. This article provides a comprehensive overview of antiplatelet and anticoagulant drugs for use before, during, and after interventional radiological procedures.

  5. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  6. Image Georeferencing Lesson 4: Image Georeferencing

    E-Print Network [OSTI]

    Butler, Christopher J.

    vector digitizing. You should read the section "Coordinate Transformation", in Chapter 4 of the GIS georeferencing, also known as image registration or image transformation. We'll then update a data layers through mapping vegetation, wetlands, and land use change. While many images are provided in digital formats

  7. Fermilab | Press Room | Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermilab constructs pioneering accelerator test facility: photos, videos & graphics Click on links below images for medium and high-resolution jpeg images. When using this...

  8. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea University and Students' Union Table of Contents Page Drugs Policy Statement 2 Drugs Policy 3 1. Introduction 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4

  9. Modeling Multiple Drugs on Lung Cancer and Normal Cells using Regression

    E-Print Network [OSTI]

    Chen, Michelle

    2013-01-01

    Drug Combination . . . . . . . . . . . . . . . .n 27 vii List of Tables Drug Concentration . . . . . . .Factorial Designs in Antiviral Drug Stud- ies. ” Quality and

  10. An implantable device for localized drug delivery and sensing

    E-Print Network [OSTI]

    Daniel, Karen D

    2009-01-01

    There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

  11. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  12. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  13. Drugs in Cinema: Separating the Myths from Reality

    E-Print Network [OSTI]

    Iannicelli, Paul

    2001-01-01

    Introduction: The Evolution of Drug Abuse in Americain HAND- BOOK OF DRUG CONTROL IN THE UNITED STATES (James A.See JOSEPH SPILLANE, MODERN DRUG, MODERN MENANCE 214 (1994).

  14. Optimizing Combination Therapies with Existing and Future CML Drugs

    E-Print Network [OSTI]

    Katouli, Allen A.; Komarova, Natalia L.

    2010-01-01

    kinase inhibitors. Nat Rev Drug Discov 3: 1001–10. 12.screen: high efficacy of drug combinations. Blood 108: 2332–Abl kinase domain mutations, drug resistance, and the road

  15. The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

    E-Print Network [OSTI]

    Shugarts, Sarah; Benet, Leslie Z.

    2009-01-01

    A, Benet LZ. Effects of drug transporters on volume of4. Mizuno N, Sugiyama Y. Drug transporters: their role andand development of new drugs. Drug Metab. Pharmacokinet.

  16. Probabilistic Web Image Gathering

    E-Print Network [OSTI]

    Yanai, Keiji

    1 Probabilistic Web Image Gathering 1. Objective & background 2. Related work 3. Method 4, JAPAN (UEC) (Long-term) Objective of our Web Image Gathering Gather several hundreds of images associated with one concept from the Web without human intervention It's not image search. Non

  17. Resistance proof, folding-inhibitor drugs

    E-Print Network [OSTI]

    R. Broglia; G. Tiana; R. Berera

    2002-10-09

    Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non- conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistence.

  18. Seismic Imaging and Monitoring

    SciTech Connect (OSTI)

    Huang, Lianjie

    2012-07-09

    I give an overview of LANL's capability in seismic imaging and monitoring. I present some seismic imaging and monitoring results, including imaging of complex structures, subsalt imaging of Gulf of Mexico, fault/fracture zone imaging for geothermal exploration at the Jemez pueblo, time-lapse imaging of a walkway vertical seismic profiling data for monitoring CO{sub 2} inject at SACROC, and microseismic event locations for monitoring CO{sub 2} injection at Aneth. These examples demonstrate LANL's high-resolution and high-fidelity seismic imaging and monitoring capabilities.

  19. Food and drug reward: overlapping circuits in human obesity and addiction

    SciTech Connect (OSTI)

    Volkow N. D.; Wang G.; Volkow, N.D.; Wang, G.-J.; Fowler, J.S.; Tomasi, D.; Baler, R.

    2012-12-01

    Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense of others. This model is consistent with the fact that both drugs and food have powerful reinforcing effects - partly mediated by dopamine increases in the limbic system - that, under certain circumstances or in vulnerable individuals, could overwhelm the brain's homeostatic control mechanisms. Such parallels have generated significant interest in understanding the shared vulnerabilities and trajectories between addiction and obesity. Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and related behavioral deficits in human subjects. These results suggest that both obese and drug addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning (memory/learning), impulse control (behavioral inhibition), stress reactivity and interoceptive awareness. Here, we integrate findings predominantly derived from positron emission tomography that investigate the role of dopamine in drug addiction and in obesity and propose an updated working model to help identify treatment strategies that may benefit both of these conditions.

  20. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01

    International Journal of Drug Policy 10: 319-28. Zinberg,Norman E. 1984. Drug, Set, and Setting: The Basis forand Mirrors: The War on Drugs and the Politics of Failure.

  1. Flow cytometry aids basic cell biology research and drug discovery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have...

  2. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  3. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  4. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  5. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  6. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Drugs (ESSPAOD). 2003. The ESPAD Report 2003: Alcohol andModintryckoffset. http://www.espad.org/documents/Espad/ESPAD_reports/The_2003_ESPAD_report.pdf. Fainaru, Steve, and

  7. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01

    Throwing Away the Key or the Taxpayer’s Money? Santa Monica,sell these drugs has cost taxpayers billions of dollars eachdiffusely and the individual taxpayer cannot easily measure

  8. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  9. Image registration method for medical image sequences

    DOE Patents [OSTI]

    Gee, Timothy F.; Goddard, James S.

    2013-03-26

    Image registration of low contrast image sequences is provided. In one aspect, a desired region of an image is automatically segmented and only the desired region is registered. Active contours and adaptive thresholding of intensity or edge information may be used to segment the desired regions. A transform function is defined to register the segmented region, and sub-pixel information may be determined using one or more interpolation methods.

  10. February 2011 1906: Pure Food & Drugs Act regulated

    E-Print Network [OSTI]

    Arslan, Hüseyin

    February 2011 #12; 1906: Pure Food & Drugs Act ­ regulated adultered/misbranded food & drugs 1938: Food, Drugs, & Cosmetics Acts ­ required premarket review for safety 1962: FDCA Amendments ­ the birth for investigations of new drugs, including a requirement for informed consent #12; 21 CFR 312 Subpart A ­ general

  11. Aerosolized Delivery of Antifungal Agents

    E-Print Network [OSTI]

    Le, Jennifer; Schiller, Daryl S.

    2010-01-01

    toxicities, such as cough, which is a common adverse effecttension, can greatly influence the occurrence of cough.Induction of cough can occur when the osmolality is less

  12. Practical image based lighting 

    E-Print Network [OSTI]

    Lee, Jaemin

    2003-01-01

    information is lighting. Image based lighting that is developed to recover illumination information of the real world from photographs has recently been popular in computer graphics. In this thesis we present a practical image based lighting method. Our...

  13. Computational ghost imaging

    E-Print Network [OSTI]

    Shapiro, Jeffrey H.

    A computational ghost-imaging arrangement that uses only a single-pixel detector is described. It affords a new 3D sectioning capability and matches the resolution of pseudothermal ghost imaging.

  14. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  15. Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs

    E-Print Network [OSTI]

    Paré, Paul W.

    Mar. Drugs 2015, 13, 3154-3181; doi:10.3390/md13053154 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates Mohamed Costantino Received: 9 April 2015 / Accepted: 7 May 2015 / Published: 20 May 2015 Abstract: Marine

  16. Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs

    E-Print Network [OSTI]

    Eirin Lopez, Jose Maria

    Mar. Drugs 2013, 11, 4370-4389; doi:10.3390/md11114370 marine drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs Review Bivalve Omics: State of the Art and Potential Applications for the Biomonitoring of Harmful Marine of the marine ecosystem, constitute very valuable commercial resources in aquaculture, and have been widely used

  17. User Science Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research | URL: https:www.fin.ucar.edunetpubserver.np?find&siteimagelibrary&catalogcatalog&templatedetail.np&fielditemid&opmatches&value3438 Download Image:...

  18. Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988,

    E-Print Network [OSTI]

    Nicholson, Bruce J.

    Drug Free Workplace This notice is intended to meet the requirements of the Drug Free Workplace Act of 1988, United States Code Title 41, Chapter 81, and the Drug Free Schools and Communities Act Amendments revision date of September 1, 2016. Notice In accordance with the Drug Free Schools and Communities Act

  19. Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super-Target Clustering1

    E-Print Network [OSTI]

    Chin, Francis Y.L.

    Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super.hku.hk, FYLC: chin@cs.hku.hk * To whom correspondence should be addressed. Abstract--Predicting drug-target interaction using computa- tional approaches is an important step in drug discovery and repositioning

  20. Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by

    E-Print Network [OSTI]

    Salt, Alec N.

    1 Section 21: Drug Discovery/Delivery Pharmacokinetic Considerations of Local Drug Delivery.Plontke@uni-tuebingen.de Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empirically- based. As a result

  1. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  2. Analyzing and improving image quality in reflective ghost imaging

    E-Print Network [OSTI]

    Hardy, Nicholas D. (Nicholas David)

    2011-01-01

    Ghost imaging is a transverse imaging technique that relies on the correlation between a pair of light fields, one that has interacted with the object to be imaged and one that has not. Most ghost imaging experiments have ...

  3. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

  4. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

  5. Image Sensor Application

    E-Print Network [OSTI]

    Stanford University

    ; #12; #12; Image Sensor Lens Metadata Actions Flash ... Application Processor Con gure 1 and Statistics #12; Image Sensor Lens Metadata Actions Flash ... Application Processor Con gure 1 Expose 2 and Statistics #12; Image Sensor Lens Metadata Actions Flash ... Application Processor Con gure 1 Expose 2

  6. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V

    2013-06-25

    A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

  7. Near-electrode imager

    DOE Patents [OSTI]

    Rathke, Jerome W. (Lockport, IL); Klingler, Robert J. (Westmont, IL); Woelk, Klaus (Wachtberg, DE); Gerald, II, Rex E. (Brookfield, IL)

    2000-01-01

    An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager uses the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

  8. Automation in image cytometry : continuous HCS and kinetic image cytometry

    E-Print Network [OSTI]

    Charlot, David J.

    2012-01-01

    OF CALIFORNIA, SAN DIEGO Automation in Image Cytometry:xiv Abstract of Dissertation Automation in Image Cytometry:

  9. Fourier plane imaging microscopy

    SciTech Connect (OSTI)

    Dominguez, Daniel, E-mail: daniel.dominguez@ttu.edu; Peralta, Luis Grave de [Department of Physics, Texas Tech University, Lubbock, Texas 79409 (United States); Nano Tech Center, Texas Tech University, Lubbock, Texas 79409 (United States); Alharbi, Nouf; Alhusain, Mdhaoui [Department of Physics, Texas Tech University, Lubbock, Texas 79409 (United States); Bernussi, Ayrton A. [Nano Tech Center, Texas Tech University, Lubbock, Texas 79409 (United States); Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, Texas 79409 (United States)

    2014-09-14

    We show how the image of an unresolved photonic crystal can be reconstructed using a single Fourier plane (FP) image obtained with a second camera that was added to a traditional compound microscope. We discuss how Fourier plane imaging microscopy is an application of a remarkable property of the obtained FP images: they contain more information about the photonic crystals than the images recorded by the camera commonly placed at the real plane of the microscope. We argue that the experimental results support the hypothesis that surface waves, contributing to enhanced resolution abilities, were optically excited in the studied photonic crystals.

  10. B Academy of Molecular Imaging and Society for Molecular Imaging, 2011 DOI: 10.1007/s11307-011-0473-7

    E-Print Network [OSTI]

    Suslick, Kenneth S.

    Avenue, Urbana 61801, IL, USA 3 Medical Scholars Program, University of Illinois at Urbana-Champaign, 506 with a suspension of iron oxide nanoparticles in oil are demonstrated as multimodal contrast agents in magnetic imaging system. These targeted oil-filled protein microspheres with the capacity for high drug

  11. Alcohol and Other Drugs Education and Prevention

    E-Print Network [OSTI]

    . · The School's commitment to conducting a biennial review of its program. Employees, like students, are coveredAlcohol and Other Drugs Education and Prevention Policy Responsible Administrative Unit: Student.0 BACKGROUND AND PURPOSE The Colorado School of Mines is committed to: · Providing students educational

  12. RELATED ARTICLES Pricey Hepatitis C Drug Draws

    E-Print Network [OSTI]

    Kay, Mark A.

    Listen Tweet 28 RELATED ARTICLES Pricey Hepatitis C Drug Draws Criticism World Hepatitis Day Highlights Global Scourge, Hopes for Treatment News / Health Elimination of Chronic Hepatitis Feasible FILE A nurse vaccinates a child against hepatitis to prevent disease in Constitucion, Chile. Lisa Schlein July

  13. Image compression technique

    DOE Patents [OSTI]

    Fu, C.Y.; Petrich, L.I.

    1997-03-25

    An image is compressed by identifying edge pixels of the image; creating a filled edge array of pixels each of the pixels in the filled edge array which corresponds to an edge pixel having a value equal to the value of a pixel of the image array selected in response to the edge pixel, and each of the pixels in the filled edge array which does not correspond to an edge pixel having a value which is a weighted average of the values of surrounding pixels in the filled edge array which do correspond to edge pixels; and subtracting the filled edge array from the image array to create a difference array. The edge file and the difference array are then separately compressed and transmitted or stored. The original image is later reconstructed by creating a preliminary array in response to the received edge file, and adding the preliminary array to the received difference array. Filling is accomplished by solving Laplace`s equation using a multi-grid technique. Contour and difference file coding techniques also are described. The techniques can be used in a method for processing a plurality of images by selecting a respective compression approach for each image, compressing each of the images according to the compression approach selected, and transmitting each of the images as compressed, in correspondence with an indication of the approach selected for the image. 16 figs.

  14. Image compression technique

    DOE Patents [OSTI]

    Fu, Chi-Yung (San Francisco, CA); Petrich, Loren I. (Livermore, CA)

    1997-01-01

    An image is compressed by identifying edge pixels of the image; creating a filled edge array of pixels each of the pixels in the filled edge array which corresponds to an edge pixel having a value equal to the value of a pixel of the image array selected in response to the edge pixel, and each of the pixels in the filled edge array which does not correspond to an edge pixel having a value which is a weighted average of the values of surrounding pixels in the filled edge array which do correspond to edge pixels; and subtracting the filled edge array from the image array to create a difference array. The edge file and the difference array are then separately compressed and transmitted or stored. The original image is later reconstructed by creating a preliminary array in response to the received edge file, and adding the preliminary array to the received difference array. Filling is accomplished by solving Laplace's equation using a multi-grid technique. Contour and difference file coding techniques also are described. The techniques can be used in a method for processing a plurality of images by selecting a respective compression approach for each image, compressing each of the images according to the compression approach selected, and transmitting each of the images as compressed, in correspondence with an indication of the approach selected for the image.

  15. Imaging arrangement and microscope

    DOE Patents [OSTI]

    Pertsinidis, Alexandros; Chu, Steven

    2015-12-15

    An embodiment of the present invention is an imaging arrangement that includes imaging optics, a fiducial light source, and a control system. In operation, the imaging optics separate light into first and second tight by wavelength and project the first and second light onto first and second areas within first and second detector regions, respectively. The imaging optics separate fiducial light from the fiducial light source into first and second fiducial light and project the first and second fiducial light onto third and fourth areas within the first and second detector regions, respectively. The control system adjusts alignment of the imaging optics so that the first and second fiducial light projected onto the first and second detector regions maintain relatively constant positions within the first and second detector regions, respectively. Another embodiment of the present invention is a microscope that includes the imaging arrangement.

  16. Video Toroid Cavity Imager

    DOE Patents [OSTI]

    Gerald, Rex E. II; Sanchez, Jairo; Rathke, Jerome W.

    2004-08-10

    A video toroid cavity imager for in situ measurement of electrochemical properties of an electrolytic material sample includes a cylindrical toroid cavity resonator containing the sample and employs NMR and video imaging for providing high-resolution spectral and visual information of molecular characteristics of the sample on a real-time basis. A large magnetic field is applied to the sample under controlled temperature and pressure conditions to simultaneously provide NMR spectroscopy and video imaging capabilities for investigating electrochemical transformations of materials or the evolution of long-range molecular aggregation during cooling of hydrocarbon melts. The video toroid cavity imager includes a miniature commercial video camera with an adjustable lens, a modified compression coin cell imager with a fiat circular principal detector element, and a sample mounted on a transparent circular glass disk, and provides NMR information as well as a video image of a sample, such as a polymer film, with micrometer resolution.

  17. Ferroelectric optical image comparator

    DOE Patents [OSTI]

    Butler, M.A.; Land, C.E.; Martin, S.J.; Pfeifer, K.B.

    1993-11-30

    A ferroelectric optical image comparator has a lead lanthanum zirconate titanate thin-film device which is constructed with a semi-transparent or transparent conductive first electrode on one side of the thin film, a conductive metal second electrode on the other side of the thin film, and the second electrode is in contact with a nonconducting substrate. A photoinduced current in the device represents the dot product between a stored image and an image projected onto the first electrode. One-dimensional autocorrelations are performed by measuring this current while displacing the projected image. 7 figures.

  18. Graphics and Image Standards

    Broader source: Energy.gov [DOE]

    For EERE websites and applications, follow these requirements and best practices for designing graphics and developing images. This includes making them Section 508-compliant.

  19. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, David N. (San Antonio, TX); Kiel, Johnathan L. (San Antonio, TX); Batishko, Charles R. (West Richland, WA); Stahl, Kurt A. (Richland, WA)

    1990-01-01

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.

  20. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, D.N.; Kiel, J.L.; Batishko, C.R.; Stahl, K.A.

    1990-08-14

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopic imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber. 22 figs.

  1. Fermilab | Press Room | Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When using these images, please credit Fermilab. Return to Press Release Med Res | Hi Res According to the Standard Model of particles and forces, the Higgs mechanism gives...

  2. Fermilab | Press Room | Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    using these images, please credit them as specified. Return to Press Release Med Res | Hi Res The Standard Model describes the interactions of the fundamental particle of the...

  3. Luminal flow amplifies stent-based drug deposition in arterial

    E-Print Network [OSTI]

    Levine, Evan G.

    Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

  4. Regression analysis of oncology drug licensing deal values

    E-Print Network [OSTI]

    Hawkins, Paul Allen

    2006-01-01

    This work is an attempt to explain wide variations in drug licensing deal value by using regression modeling to describe and predict the relationship between oncology drug deal characteristics and their licensing deal ...

  5. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM),...

  6. Optimization of preclinical profiling operations in drug discovery

    E-Print Network [OSTI]

    Heiney, John P. (John Patrick)

    2007-01-01

    In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...

  7. Measuring the effects of drugs on single cancer cell growth

    E-Print Network [OSTI]

    Weng, Yaochung

    2012-01-01

    Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response ...

  8. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  9. Amphiphilic linear-dendritic block copolymers for drug delivery

    E-Print Network [OSTI]

    Nguyen, Phuong, Ph. D. Massachusetts Institute of Technology

    2007-01-01

    Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. ...

  10. Alignment strategies for drug product process development and manufacturing

    E-Print Network [OSTI]

    Garvin, Christopher John

    2012-01-01

    The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

  11. Overcoming Drug Resistance by Co-Targeting Marzieh Ayati1

    E-Print Network [OSTI]

    Wong, Limsoon

    , Statistics and Computer Science, University of Tehran, Tehran, Iran Abstract Removal or suppression of key to the drug. Communica- tion to the resistance machinery---e.g., efflux pumps and drug-modifying enzymes

  12. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  13. Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs

    E-Print Network [OSTI]

    Stauber, Zachary Jason

    2012-01-01

    Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

  14. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16

    Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

  15. Research Articles Combining Drug and Gene Similarity Measures

    E-Print Network [OSTI]

    Sharan, Roded

    of drug-drug and gene-gene similarity measures, combined with a logistic regression component to detection problems due to multiple gene and compound names. Additional attempts were based on reverse

  16. Edge-based correlation image registration for multispectral imaging

    DOE Patents [OSTI]

    Nandy, Prabal (Albuquerque, NM)

    2009-11-17

    Registration information for images of a common target obtained from a plurality of different spectral bands can be obtained by combining edge detection and phase correlation. The images are edge-filtered, and pairs of the edge-filtered images are then phase correlated to produce phase correlation images. The registration information can be determined based on these phase correlation images.

  17. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement.

    E-Print Network [OSTI]

    2009-01-01

    nonsteroidal anti-in? ammatory drugs and risk of colorectalof nonsteroidal antiin? ammatory drugs: a pooled analysis ofsteroidal anti-in? ammatory drugs on colorectal adenomas:

  18. Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells.

    E-Print Network [OSTI]

    Dellinger, Ryan W; Matundan, Harry H; Ahmed, Amelia S; Duong, Priscilla H; Meyskens, Frank L Jr

    2012-01-01

    effect of valproic acid on drug and steroid glucuronidationglucuronosyltrans- ferases. Curr Drug Metab 1: 143–161. 10.aerodigestive tract tissues. Drug Metab Dispos 30: 397–403.

  19. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Thomas, Mathew; Carson, James P.; Smith, Jordan N.; Timchalk, Charles; Laskin, Julia

    2013-01-15

    Imaging mass spectrometry offers simultaneous detection of drugs, drug metabolites and endogenous substances in a single experiment. This is important when evaluating effects of a drug on a complex organ system such as the brain, where there is a need to understand how regional drug distribution impacts function. Nicotine is an addictive drug and its action in the brain is of high interest. Here we use nanospray desorption electrospray ionization, nano-DESI, imaging to discover the localization of nicotine in rat brain tissue after in vivo administration of nicotine. Nano-DESI is a new ambient technique that enables spatially-resolved analysis of tissue samples without special sample pretreatment. We demonstrate high sensitivity of nano-DESI imaging that enables detection of only 0.7 fmole nicotine per pixel in the complex brain matrix. Furthermore, by adding deuterated nicotine to the solvent, we examined how matrix effects, ion suppression, and normalization affect the observed nicotine distribution. Finally, we provide preliminary results suggesting that nicotine localizes to the hippocampal substructure called dentate gyrus.

  20. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-07-29

    The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

  1. Model-Based Dependability Analysis of Programmable Drug Infusion Pumps

    E-Print Network [OSTI]

    Sankaranarayanan, Sriram

    Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

  2. UNIVERSITY OF ABERDEEN POLICY ON DRUGS AND ALCOHOL

    E-Print Network [OSTI]

    Neri, Peter

    UNIVERSITY OF ABERDEEN POLICY ON DRUGS AND ALCOHOL 1 INTRODUCTION 1.1 The University of Aberdeen, and the introduction of a drugs and alcohol policy is intended to form an integral part of that approach. 1 and consistently. The University recognises that alcohol/drug dependency is an illness and will be treated

  3. An Algorithmic Framework for Predicting Side-Effects of Drugs

    E-Print Network [OSTI]

    Sharan, Roded

    An Algorithmic Framework for Predicting Side-Effects of Drugs Nir Atias and Roded Sharan Blavatnik,roded}@post.tau.ac.il Abstract. One of the critical stages in drug development is the iden- tification of potential side effects for promising drug leads. Large scale clinical experiments aimed at discovering such side effects are very

  4. Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

    E-Print Network [OSTI]

    Drug-free Workplace Policy Responsible Administrative Unit: Human Resources Policy Contact, students, and other individuals in our workplace and campus community. Alcohol abuse and drug use can pose.1 There are many risks associated with the use of illicit drugs and the abuse of alcohol, including physical

  5. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  6. Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses

    E-Print Network [OSTI]

    Wood, Michelle

    2011-12-31

    This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research ...

  7. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  8. Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating

    E-Print Network [OSTI]

    Zhu, Xiaoxiang, Ph. D. Massachusetts Institute of Technology

    2014-01-01

    Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant ...

  9. Scandinavian Workshop on Imaging

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Barcode Imaging of Chocolate Milk Quan.fica.on of Microstructures in Freeze.on of Fat Content in Raw Beef Cut Meat Evalua.on by RGB-to-spectrum Imaging.on to Visualizing Meat Products Characteriza.on of Commercial Danish Apple Cul.var Using Novel

  10. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2012-07-24

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

  11. COVER IMAGE Mechanical metamaterials

    E-Print Network [OSTI]

    Loss, Daniel

    COVER IMAGE Mechanical metamaterials are artificial structures whose properties originate from a range of structural deformations. Letter p153; News & Views p95 IMAGE: JAYSON PAULOSE COVER DESIGN in elementary optical excitations of monolayer WSe2 Ajit Srivastava, Meinrad Sidler, Adrien V. Allain, Dominik S

  12. Heart imaging method

    DOE Patents [OSTI]

    Collins, H. Dale (Richland, WA); Gribble, R. Parks (Richland, WA); Busse, Lawrence J. (Littleton, CO)

    1991-01-01

    A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.

  13. Fluorescent image tracking velocimeter

    DOE Patents [OSTI]

    Shaffer, Franklin D. (Library, PA)

    1994-01-01

    A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

  14. Adaptive wiener image restoration kernel

    DOE Patents [OSTI]

    Yuan, Ding (Henderson, NV)

    2007-06-05

    A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

  15. Content-Aware Image enhancement

    E-Print Network [OSTI]

    Schettini, Raimondo

    Content-Aware Image enhancement R. Schettini www.ivl.disco.unimib.it #12;8 Faculties, 61 Degree Recognition Content-based retrieval Quality Assessment #12;Content-Aware Image Enhancement Presentation Image Processing Content aware image enhancement We focus here on image based features. And show how

  16. Image forming apparatus

    DOE Patents [OSTI]

    Satoh, Hisao (Hachioji, JP); Haneda, Satoshi (Hachioji, JP); Ikeda, Tadayoshi (Hachioji, JP); Morita, Shizuo (Hachioji, JP); Fukuchi, Masakazu (Hachioji, JP)

    1996-01-01

    In an image forming apparatus having a detachable process cartridge in which an image carrier on which an electrostatic latent image is formed, and a developing unit which develops the electrostatic latent image so that a toner image can be formed, both integrally formed into one unit. There is provided a developer container including a discharge section which can be inserted into a supply opening of the developing unit, and a container in which a predetermined amount of developer is contained, wherein the developer container is provided to the toner supply opening of the developing unit and the developer is supplied into the developing unit housing when a toner stirring screw of the developing unit is rotated.

  17. Time encoded radiation imaging

    DOE Patents [OSTI]

    Marleau, Peter; Brubaker, Erik; Kiff, Scott

    2014-10-21

    The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

  18. Confocal coded aperture imaging

    DOE Patents [OSTI]

    Tobin, Jr., Kenneth William (Harriman, TN); Thomas, Jr., Clarence E. (Knoxville, TN)

    2001-01-01

    A method for imaging a target volume comprises the steps of: radiating a small bandwidth of energy toward the target volume; focusing the small bandwidth of energy into a beam; moving the target volume through a plurality of positions within the focused beam; collecting a beam of energy scattered from the target volume with a non-diffractive confocal coded aperture; generating a shadow image of said aperture from every point source of radiation in the target volume; and, reconstructing the shadow image into a 3-dimensional image of the every point source by mathematically correlating the shadow image with a digital or analog version of the coded aperture. The method can comprise the step of collecting the beam of energy scattered from the target volume with a Fresnel zone plate.

  19. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery

    SciTech Connect (OSTI)

    Tsai, Yingssu; McPhillips, Scott E.; González, Ana; McPhillips, Timothy M.; Zinn, Daniel; Cohen, Aina E.; Feese, Michael D.; Bushnell, David; Tiefenbrunn, Theresa; Stout, C. David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O.; Soltis, S. Michael

    2013-05-01

    New software has been developed for automating the experimental and data-processing stages of fragment-based drug discovery at a macromolecular crystallography beamline. A new workflow-automation framework orchestrates beamline-control and data-analysis software while organizing results from multiple samples. AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully demonstrated. This workflow was run once on the same 96 samples that the group had examined manually and the workflow cycled successfully through all of the samples, collected data from the same samples that were selected manually and located the same peaks of unmodeled density in the resulting difference Fourier maps.

  20. Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test a positive result with probability .98 in the case that the tested individual uses the drug) and 90% accurate not use the drug). Suppose it is known that 10% of the entire population uses this drug. You test someone

  1. Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Seto, Jennifer Elizabeth

    2011-01-01

    Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

  2. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

    1983-03-11

    It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

  3. Colour Image Segmentation Wladyslaw Skarbek

    E-Print Network [OSTI]

    Koschan, Andreas

    Colour Image Segmentation A Survey Wladyslaw Skarbek Institute of Computer Science Polish Academy . . . . . . . . . . . . . . . . . . . . . . . . 23 4.2.1 Colour image segmentation and labeling through multiediting and condensing

  4. A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions

    E-Print Network [OSTI]

    Baral, Chitta

    A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions Jörg, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reac- tions in individuals whose drug metabolism drastically differs from

  5. A search for interaction among combinations of drugs of abuse and the use of isobolographic analysis

    E-Print Network [OSTI]

    Obradovic, Zoran

    Commentary A search for interaction among combinations of drugs of abuse and the use: abused drugs, drug combinations, isobole, multi-drug abuse, synergy SUMMARY What is known and Objective: Individuals who abuse drugs usually use more than one substance. Toxic consequences of single and multi-drug

  6. Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture

    DOE Patents [OSTI]

    Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S.

    2013-01-08

    Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates.

  7. T? tunable porous silicon iron oxide nanocomposites for magnetic resonance imaging guided drug delivey

    E-Print Network [OSTI]

    Ananda Yogendran, Shalini

    2012-01-01

    > y) & (0 z)) if (sqrt(pwr(x-xpos[sphere],2) + pwr (y-ypos[sphere],2)+pwr( z-zpos[sphere], 2)) <=sphere_radius) { int

  8. Imaging through scattering

    E-Print Network [OSTI]

    Satat, Guy

    2015-01-01

    In this thesis we demonstrate novel methods to overcome optical scattering in order to resolve information about hidden scenes, in particular for biomedical applications. Imaging through scattering media has long been a ...

  9. Photothermal imaging scanning microscopy

    DOE Patents [OSTI]

    Chinn, Diane (Pleasanton, CA); Stolz, Christopher J. (Lathrop, CA); Wu, Zhouling (Pleasanton, CA); Huber, Robert (Discovery Bay, CA); Weinzapfel, Carolyn (Tracy, CA)

    2006-07-11

    Photothermal Imaging Scanning Microscopy produces a rapid, thermal-based, non-destructive characterization apparatus. Also, a photothermal characterization method of surface and subsurface features includes micron and nanoscale spatial resolution of meter-sized optical materials.

  10. Quantum-mimetic imaging

    E-Print Network [OSTI]

    Venkatraman, Dheera

    2015-01-01

    Many recent experiments have explored the use of nonclassical states of light to perform imaging or sensing. Although these experiments require quantum descriptions of light to explain their behavior, the advantages they ...

  11. Building an urban image

    E-Print Network [OSTI]

    Russin, Andrew J

    1992-01-01

    This design project explores the principles of "urban legibility" and "shared space". The readability, or imageability (in Kevin Lynch's term) of a city results from the recognition of larger urban patterns, organizations, ...

  12. Reflective optical imaging system

    DOE Patents [OSTI]

    Shafer, David R. (Fairfield, CT)

    2000-01-01

    An optical system compatible with short wavelength (extreme ultraviolet) radiation comprising four reflective elements for projecting a mask image onto a substrate. The four optical elements are characterized in order from object to image as convex, concave, convex and concave mirrors. The optical system is particularly suited for step and scan lithography methods. The invention increases the slit dimensions associated with ringfield scanning optics, improves wafer throughput and allows higher semiconductor device density.

  13. The SDSS Imaging Pipelines

    E-Print Network [OSTI]

    Robert Lupton; James E. Gunn; Zeljko Ivezic; Gillian R. Knapp; Stephen Kent; Naoki Yasuda

    2001-05-24

    We summarise the properties of the Sloan Digital Sky Survey (SDSS) project, discuss our software infrastructure, and outline the architecture of the SDSS image processing pipelines. We then discuss two of the algorithms used in the SDSS image processing; the KL-transform based modelling of the spatial variation of the PSF, and the use of galaxy models in star/galaxy separation. We conclude with the first author's personal opinions on the challenges that the astronomical community faces with major software projects.

  14. Title: Drug and Alcohol Policies --Drug-Free Workplace Code: 1-300-020

    E-Print Network [OSTI]

    Huang, Jianyu

    -free workplace, and, in the case of grantees who are individuals, by requiring each individual to certify to receiving a contract or grant from a federal agency. All grantees who fail to meet the drug-free workplace of the Act. Grantees are not required to make a certification in order to continue receiving funds under

  15. Fluid Imaging of Enhanced Geothermal Systems

    Broader source: Energy.gov [DOE]

    Project objectives: Attempting to Image EGS Fracture & Fluid Networks; Employing joint Geophysical Imaging Technologies.

  16. Content-Aware Image enhancement

    E-Print Network [OSTI]

    Schettini, Raimondo

    1 Content-Aware Image enhancement R. Schettini www.ivl.disco.unimib.it 8 Faculties, 61 Degree Recognition Content-based retrieval Quality Assessment Content-Aware Image Enhancement Presentation Outline Processing Content aware image enhancement We focus here on image based features. And show how to exploit

  17. BAYESIAN ENSEMBLE LEARNING FOR MEDICAL IMAGE DENOISING

    E-Print Network [OSTI]

    Oh, Hyuntaek

    2012-08-31

    Medical images are often affected by random noise because of both image acquisition from the medical modalities and image transmission from modalities to workspace in the main computer. Medical image denoising removes noise from the CT or MR images...

  18. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Print Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of...

  19. Intratumor heterogeneity alters most effective drugs in designed combinations

    E-Print Network [OSTI]

    Zhao, Boyang

    The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with predictable outcomes. Currently, the implications of tissue ...

  20. Nobel Laureate speaks on antibiotics and drug resistance | ornl...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nobel Laureate speaks on antibiotics and drug resistance Ramakrishnan cited several pioneers of antibiotic research in his talk. Ramakrishnan cited several pioneers of antibiotic...

  1. Cellulose, Chitosan, and Keratin Composite Materials. Controlled Drug Release

    E-Print Network [OSTI]

    Reid, Scott A.

    Cellulose, Chitosan, and Keratin Composite Materials. Controlled Drug Release Chieu D. Tran 53201, United States *S Supporting Information ABSTRACT: A method was developed in which cellulose (CEL

  2. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  3. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Energy Savers [EERE]

    Stewardship and Cost Savings FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus. PDF icon...

  4. In silico modeling to predict drug-induced phospholipidosis

    SciTech Connect (OSTI)

    Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

    2013-06-01

    Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structure–activity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 80–81% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: • New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. • The training set data in the models is derived from the FDA's phospholipidosis database. • We find excellent predictivity values of the models based on external validation. • The models can support drug screening and regulatory decision-making on DIPL.

  5. Microbial Cell Imaging

    SciTech Connect (OSTI)

    Doktycz, Mitchel John; Sullivan, Claretta; Mortensen, Ninell P; Allison, David P

    2011-01-01

    Atomic force microscopy (AFM) is finding increasing application in a variety of fields including microbiology. Until the emergence of AFM, techniques for ivnestigating processes in single microbes were limited. From a biologist's perspective, the fact that AFM can be used to generate high-resolution images in buffers or media is its most appealing feature as live-cell imaging can be pursued. Imaging living cells by AFM allows dynamic biological events to be studied, at the nanoscale, in real time. Few areas of biological research have as much to gain as microbiology from the application of AFM. Whereas the scale of microbes places them near the limit of resolution for light microscopy. AFM is well suited for the study of structures on the order of a micron or less. Although electron microscopy techniques have been the standard for high-resolution imaging of microbes, AFM is quickly gaining favor for several reasons. First, fixatives that impair biological activity are not required. Second, AFM is capable of detecting forces in the pN range, and precise control of the force applied to the cantilever can be maintained. This combination facilitates the evaluation of physical characteristics of microbes. Third, rather than yielding the composite, statistical average of cell populations, as is the case with many biochemical assays, the behavior of single cells can be monitored. Despite the potential of AFM in microbiology, there are several limitations that must be considered. For example, the time required to record an image allows for the study of gross events such as cell division or membrane degradation from an antibiotic but precludes the evaluation of biological reactions and events that happen in just fractions of a second. Additionally, the AFM is a topographical tool and is restricted to imaging surfaces. Therefore, it cannot be used to look inside cells as with opticla and transmission electron microscopes. other practical considerations are the limitation on the maximum scan size (roughly 100 x 100 {mu}m) and the restricted movement of the cantilever in the Z (or height) direction. In most commercial AFMs, the Z range is restricted to roughly 10 {mu}m such that the height of cells to be imaged must be seriously considered. Nevertheless, AFM can provide structural-functional information at nanometer resolution and do so in physiologically relevant environments. Further, instrumentation for scanning probe microscopy continues to advance. Systems for high-speed imaging are becoming available, and techniques for looking inside the cells are being demonstrated. The ability to combine AFM with other imaging modalities is likely to have an even greater impact on microbiological studies. AFM studies of intact microbial cells started to appear in the literature in the 1990s. For example, AFM studies of Saccharomyces cerevisiae examined buddings cars after cell division and detailed changes related to cell growth processes. Also, the first AFM studies of bacterial biofilms appeared. In the late 1990s, AFM studies of intact fungal spores described clear changes in spore surfaces upon germination, and studies of individual bacterial cells were also described. These early bacterial imaging studies examined changes in bacterial morphology due to antimicrobial peptides exposure and bacterial adhesion properties. The majority of these early studies were carried out on dried samples and took advantage of the resolving power of AFM. The lack of cell mounting procedures presented an impediment for cell imaging studies. Subsequently, several approaches to mounting microbial cells have been developed, and these techniques are described later. Also highlighted are general considerations for microbial imaging and a description of some of the various applications of AFM to microbiology.

  6. Multispectral imaging probe

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Descour, M.R.; Armour, D.L.; Craig, M.J.; Richards-Kortum, R.

    1999-07-27

    A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector. 8 figs.

  7. Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs

    SciTech Connect (OSTI)

    Rosenfeldt, Hans; Kropp, Timothy; Benson, Kimberly; Ricci, M. Stacey; McGuinn, W. David; Verbois, S. Leigh

    2010-03-01

    The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements.

  8. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  9. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  10. Revealing the paradox of drug reward in human evolution

    E-Print Network [OSTI]

    ; Nestler 2005). Most commonly used psychoactive drugs are plant secondary metabolites (e.g. alkaloids secondary metabolites, including alkaloids such as nicotine, morphine and cocaine, are potent neurotoxins. However, the most commonly used drugs are plant neurotoxins that evolved to punish, not reward

  11. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-06

    The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

  12. Experimental Models of Anxiety for Drug Discovery and Brain Research

    E-Print Network [OSTI]

    Kalueff, Allan V.

    Chapter 18 Experimental Models of Anxiety for Drug Discovery and Brain Research Peter C. Hart and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds+Business Media, LLC 2010 299 #12;300 Hart et al. It is important to understand, however, that any animal exper

  13. Alternative Breaks Alcohol and Drug Policy 2014-2015

    E-Print Network [OSTI]

    Tipple, Brett

    Alternative Breaks Alcohol and Drug Policy 2014-2015 In order to promote personal development order and stability on Alternative Break trips, the following standards concerning drug and alcohol use have been set and will be enforced on all Alternative Break trips: 1. Use, possession or distribution

  14. Imaging agents for in vivo magnetic resonance and scintigraphic imaging

    DOE Patents [OSTI]

    Engelstad, B.L.; Raymond, K.N.; Huberty, J.P.; White, D.L.

    1991-04-23

    Methods are provided for in vivo magnetic resonance imaging and/or scintigraphic imaging of a subject using chelated transition metal and lanthanide metal complexes. Novel ligands for these complexes are provided. No Drawings

  15. Image Charge Differential

    E-Print Network [OSTI]

    Weston, Ken

    Image Charge Differential Amplifier FT 0 Crude Oil Time (s) 543210 Frequency (kHz) m/z m q B f organic molecules such as heavy crude oils. Heavy crudes are some of the most complex organic mixtures found in nature. As the crude oil industry grows in size and demand for crude oil increases, techniques

  16. Time-Encoded Imagers.

    SciTech Connect (OSTI)

    Marleau, Peter; Brubaker, Erik

    2014-11-01

    This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

  17. Department of Botany, 3359 Mississauga Road

    E-Print Network [OSTI]

    Anderson, James B.

    as resistance to antibacterial agents in bacteria1 , one long-term concern is that the number of fundamentally EVOLUTION OF ANTIFUNGAL DRUG RESISTANCE: MECHANISMS AND PATHOGEN FITNESS James B. Anderson Abstract | Like by antifungal drugs, drug-sensitive fungal pathogens frequently evolve resistance. Although the molecular

  18. Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List

    E-Print Network [OSTI]

    Oklahoma, University of

    Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List PLEASE READ: THIS DOCUMENT CONTAINS DrugList Blue MedicareRx (PDP)SM 2012 Formulary (List of Covered Drugs) DrugList PLEASE READ. Blue MedicareRx (PDP) is a stand-alone prescription drug plan with a Medicare contract offered by HCSC

  19. Drug Resistance Updates 15 (2012) 9097 Contents lists available at SciVerse ScienceDirect

    E-Print Network [OSTI]

    Levy, Doron

    2012-01-01

    Drug Resistance Updates 15 (2012) 90­97 Contents lists available at SciVerse ScienceDirect Drug Resistance Updates journal homepage: www.elsevier.com/locate/drup The dynamics of drug resistance Park, MD, USA a r t i c l e i n f o Keywords: Drug-dependent/independent resistance Drug scheduling

  20. Drug-Free Workplace Program UT-B Contracts Page 1 of 1

    E-Print Network [OSTI]

    Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

  1. Image Utility Assessment and a Relationship with Image Quality Assessment

    E-Print Network [OSTI]

    Hemami, Sheila S.

    Image Utility Assessment and a Relationship with Image Quality Assessment David M. Rouse , Romuald information to humans, and this paper investigates the utility assessment task, where human observers evaluate the usefulness of a natural image as a surrogate for a reference. Current QA algorithms implicitly assess utility

  2. Efficient MR Image Reconstruction for Compressed MR Imaging

    E-Print Network [OSTI]

    Huang, Junzhou

    demonstrate the superior performance of the proposed algorithm for com- pressed MR image reconstruction. 1 [1][2] show that it is possi- ble to accurately reconstruct the Magnetic Resonance (MR) images from for real MR images. Computation became the bottleneck that prevented this good model (1) from being used

  3. Array combination for parallel imaging in Magnetic Resonance Imaging 

    E-Print Network [OSTI]

    Spence, Dan Kenrick

    2007-09-17

    In Magnetic Resonance Imaging, the time required to generate an image is proportional to the number of steps used to encode the spatial information. In rapid imaging, an array of coil elements and receivers are used to reduce the number of encoding...

  4. Instruments High-resolution imaging of

    E-Print Network [OSTI]

    Boppart, Stephen

    Instruments & Methods High-resolution imaging of gynecologic neoplasms using optical coherence and Gynecologists.) Diagnostic imaging methods available to gynecologists include magnetic resonance imaging (MRI

  5. Call for Papers for 3rd Annual Diabetes Care Symposium "New Drug Therapies, Innovative Management Strategies, and Novel Drug Targets"

    E-Print Network [OSTI]

    Kaski, Samuel

    Call for Papers for 3rd Annual Diabetes Care Symposium "New Drug Therapies, Innovative Management submissions for the 3rd Annual Diabetes Care Symposium, titled "New Drug Therapies, Innovative Management, at http://mc.manuscriptcentral.com/diabetescare. When submitting your manuscript, please mention the 3rd

  6. Image texture analysis of elastograms 

    E-Print Network [OSTI]

    Hussain, Fasahat

    1999-01-01

    and developed to make it a commercial product. 'This research applies image texture analysis to computer generated elastograms to obtain effective texture features. Four image analysis techniques, no-occurrence statistics, wavelet decomposition, frontal analysis...

  7. Topics in genomic image processing 

    E-Print Network [OSTI]

    Hua, Jianping

    2006-04-12

    The image processing methodologies that have been actively studied and developed now play a very significant role in the flourishing biotechnology research. This work studies, develops and implements several image processing techniques for M...

  8. Digital holographic imaging of microorganisms

    E-Print Network [OSTI]

    Wolf, Michael Trevor

    2006-01-01

    Imaging aquatic microorganisms in 3D space is of interest to biologists and ocean scientists seeking to understand the behavior of these organisms in their natural environments. In this research, digital holographic imaging ...

  9. Name______________________________________Drug-like Properties all answers must fit in space provided Imagine that a drug discovery program generated the two lead compounds shown below. The

    E-Print Network [OSTI]

    Gates, Kent. S.

    Name______________________________________Drug-like Properties all answers must fit in space provided 1 Imagine that a drug discovery program generated the two lead compounds shown below designed to facilitate drug discovery. We'll be using a free, web-based application that calculates drug

  10. One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting

    E-Print Network [OSTI]

    Metlushko, Vitali

    One of the main issues with drug delivery is that drugs tend to disperse throughout the entire body, instead of targeting the specific site (or area) that it is intended to reach. Therefore, drugs candidates for more focused drug delivery systems is magnetic manipulation of nanoparticles

  11. Fourier Analysis of Ghost Imaging

    E-Print Network [OSTI]

    Honglin Liu; Jing Cheng; Yanfeng Bai; Shensheng Han

    2006-09-28

    Fourier analysis of ghost imaging (FAGI) is proposed in this paper to analyze the properties of ghost imaging with thermal light sources. This new theory is compatible with the general correlation theory of intensity fluctuation and could explain some amazed phenomena. Furthermore we design a series of experiments to verify the new theory and investigate the inherent properties of ghost imaging.

  12. Chester F. Carlson Imaging Science?

    E-Print Network [OSTI]

    Salvaggio, Carl

    GRADUATE STUDIES Chester F. Carlson CENTERfor IMAGING SCIENCE GORITHM 60 (b) #12;What is Imaging Science? Imaging Scientists work with science and technology that is focused on the creation. Research areas include: Remote Sensing Vision and Perception Astronomy and Space Science Computational

  13. Biomechanics Volumetric imaging of fish

    E-Print Network [OSTI]

    Lauder, George V.

    Biomechanics Volumetric imaging of fish locomotion Brooke E. Flammang1,*, George V. Lauder1, Daniel stability in a complex fluid environ- ment. We used a new approach, a volumetric velocimetry imaging system into the caudal fin vortex wake. These results show that volumetric imaging of biologi- cally generated flow

  14. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China

    E-Print Network [OSTI]

    2013-01-01

    Hsiang et al. : Mass drug administration for the control andL, Greenwood BM: Mass administrations of antimalarial drugs.Skarbinski J: Mass drug administration for malaria. Cochrane

  15. Regulatory approval of cancer risk-reducing (chemopreventive) drugs: moving what we have learned into the clinic.

    E-Print Network [OSTI]

    2011-01-01

    Risk-Reducing (Chemopreventive) Drugs: Moving What We Haverisk reduction) drugs and discusses possible improvements toof Cancer Risk- Reducing Drugs approach along with primary

  16. Multimode imaging device

    DOE Patents [OSTI]

    Mihailescu, Lucian; Vetter, Kai M

    2013-08-27

    Apparatus for detecting and locating a source of gamma rays of energies ranging from 10-20 keV to several MeV's includes plural gamma ray detectors arranged in a generally closed extended array so as to provide Compton scattering imaging and coded aperture imaging simultaneously. First detectors are arranged in a spaced manner about a surface defining the closed extended array which may be in the form a circle, a sphere, a square, a pentagon or higher order polygon. Some of the gamma rays are absorbed by the first detectors closest to the gamma source in Compton scattering, while the photons that go unabsorbed by passing through gaps disposed between adjacent first detectors are incident upon second detectors disposed on the side farthest from the gamma ray source, where the first spaced detectors form a coded aperture array for two or three dimensional gamma ray source detection.

  17. Prenatal Exposure to Nitrates, Nitrites, and Nitrosatable Drugs and Preterm Births 

    E-Print Network [OSTI]

    Vuong, Ann Minh

    2013-10-28

    , we examined the relation between preterm births and: 1) prenatal nitrosatable drug usage; 2) dietary intake of nitrates/nitrites; 3) joint exposures to nitrosatable drugs and nitrate/nitrite intake; and 4) nitrosatable drugs and vitamin C intake among...

  18. Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications

    E-Print Network [OSTI]

    Edward, Jonathan M. (Jonathan Mark)

    2008-01-01

    Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

  19. HIV-related sexual behaviors, drugs, and violence among high risk populations in Baja California, Mexico

    E-Print Network [OSTI]

    Volkmann, Tyson Alexander

    2012-01-01

    USDOJ, Alcohol, tobacco and other drug use by youth in ruralmale and female injection drug users in Tijuana, Mexico.International Journal of Drug Policy, 2003. 14(1): p. 45-62.

  20. Sexuality Under the Influence: The Queer Pleasures of Illicit Drugs in Transatlantic Gay and Lesbian Culture

    E-Print Network [OSTI]

    Randolph, Patrick

    2011-01-01

    Susan. Inventing the Addict: Drugs, Race, and Sexuality inPrint. ---. “Queering the Drug Diary: Go Ask Alice and ItsDavid T. Forces of Habit: Drugs and the Making of the Modern

  1. A Healthy Business: The evolution of the U.S. market for prescription drugs

    E-Print Network [OSTI]

    Younkin, Peter Allen

    2010-01-01

    1903. "Cheating in the Drug Trade." in New York Times.New York. 1904. "Dishonest Drugs." in New York Times. New1960. "Senators Scored on Drug Inquiry." in New York Times.

  2. Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity

    E-Print Network [OSTI]

    2012-01-01

    blood pressure lowering drugs: analysis of 354 randomisedKSHV) with combinatory drugs. Integr Biol (Camb). 2009;1(1):matrix metalloproteinases as drug targets and anti-targets

  3. Fast Algorithms for Image Reconstruction with Application to Partially Parallel MR Imaging

    E-Print Network [OSTI]

    Yin, Wotao

    Fast Algorithms for Image Reconstruction with Application to Partially Parallel MR Imaging Yunmei. Key words. Image reconstruction, Variable splitting, TV denoising, Nonlinear optimization 1 from an emerging magnetic resonance (MR) medical imaging technique known as partially parallel imaging

  4. Bistatic SAR: Imagery & Image Products.

    SciTech Connect (OSTI)

    Yocky, David A.; Wahl, Daniel E.; Jakowatz, Charles V,

    2014-10-01

    While typical SAR imaging employs a co-located (monostatic) RADAR transmitter and receiver, bistatic SAR imaging separates the transmitter and receiver locations. The transmitter and receiver geometry determines if the scattered signal is back scatter, forward scatter, or side scatter. The monostatic SAR image is backscatter. Therefore, depending on the transmitter/receiver collection geometry, the captured imagery may be quite different that that sensed at the monostatic SAR. This document presents imagery and image products formed from captured signals during the validation stage of the bistatic SAR research. Image quality and image characteristics are discussed first. Then image products such as two-color multi-view (2CMV) and coherent change detection (CCD) are presented.

  5. Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

    E-Print Network [OSTI]

    Perez-Lopez, Aron R; Turei, Denes; Modos, Dezso; Lenti, Katalin; Korcsmaros, Tamas; Csermely, Peter

    2015-01-01

    Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no reported side effects. Our results showed that in general, drug targets were better spreaders of perturbations than non-target proteins, and in particular, targets of drugs with side effects were also better spreaders of perturbations than targets of drugs having no reported side effects in human protein-protein interaction networks. Colorectal cancer-related proteins were good spreaders and had a high centrality, while type 2 diabetes-related proteins showed an average spreading efficiency and had an average centrality in the human interactome. Moreover, the interactome-distance between drug targets and disease-related proteins was higher in diabetes than in colorectal cancer. Our results may help a better understan...

  6. What are the public health effects of direct-to-consumer drug advertising?

    E-Print Network [OSTI]

    Almasi, Elizabeth A; Stafford, Randall S; Kravitz, Richard L; Mansfield, Peter R

    2006-01-01

    to-consumer prescription drug Advertising. Health Commun 16:2004) Direct-to-consumer advertising of prescription drugs:2003) Direct-to-consumer advertising: Physicians’ views on

  7. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release

    E-Print Network [OSTI]

    Hoare, Todd

    Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on?off drug release upon application (and removal) ...

  8. Drug Court Effectiveness: A Review of California Evaluation Reports, 1995-1999

    E-Print Network [OSTI]

    Guydish, Joseph R PhD; Wolfe, Ellen; Tajima, Barbara; Woods, William J

    2006-01-01

    Evaluation qfthe Oakland Drug Court Afur ?ue Ycan. Onklsnd.39; Journal ¢JP:ydIurclive Drugs 378 - -. ~z. ~. ;- Sa;;n"IDrug Courl::

  9. Photogrammetry & Machine Vision 1. Image sensors

    E-Print Network [OSTI]

    Giger, Christine

    Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image. Remondino, N. D'Apuzzo Photogrammetry and Machine Vision ­ 1. Measurement in images (b) Camera calibration of Photogrammetry and Machine Vision Fully understand: 1. Image based 3D and 4D measurement 2. Image based 3D

  10. Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

    E-Print Network [OSTI]

    Singh, Neetu

    Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we ...

  11. Near-infrared-actuated devices for remotely controlled drug delivery

    E-Print Network [OSTI]

    Timko, Brian P.

    A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage ...

  12. Engineered microtissue platforms for modeling human pathophysiology and drug metabolism

    E-Print Network [OSTI]

    Li, Cheri Yingjie

    2013-01-01

    Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

  13. Drugs CSA Schedules Medical Uses Physical Usual Method Possible Effects

    E-Print Network [OSTI]

    Subramanian, Venkat

    Drugs CSA Schedules Medical Uses Physical Psycho- logical Toleranc e Duration (Hours) Usual Method Hashish and Hashish Oil Substance I Hash, Hash oil None Unknown Moderate Yes 2-4 Smoked, oral Anabolic

  14. Biosynthetic engineering for the assembly of better drugs

    E-Print Network [OSTI]

    Yadav, Vikramaditya Ganapati

    2013-01-01

    The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

  15. Use of physical enhancers for gastrointestinal and transdermal drug delivery

    E-Print Network [OSTI]

    Schoelihammer, Carl M. (Carl Magnus)

    2015-01-01

    The research presented in this thesis represents a significant advance in the field of transdermal- and gastrointestinal (GI)-based drug delivery. With regards to the former, previous work has led to a thorough mechanistic ...

  16. Cellular responses against DNA damaged by platinum anticancer drugs

    E-Print Network [OSTI]

    Jung, Yongwon, 1977-

    2005-01-01

    The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...

  17. Biocompatibility of an implantable ophthalmic drug delivery device

    E-Print Network [OSTI]

    Cohen, Sarah J. (Sarah Jennifer)

    2007-01-01

    Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

  18. Streamlining data management in drug product commercialization and manufacturing

    E-Print Network [OSTI]

    Anderson, Spencer C. (Spencer Clark)

    2014-01-01

    Effective execution and alignment of data management across development and manufacturing teams is essential for Amgen's Drug Product Technology group to realize its main goals of shortening the development timeline and ...

  19. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  20. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  1. A research-inspired laboratory sequence investigating acquired drug resistance

    E-Print Network [OSTI]

    Taylor, Elizabeth Vogel

    Here, we present a six-session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug ...

  2. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

    E-Print Network [OSTI]

    Tong, Rong

    We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  4. Titanium MEMS Technology Development for Drug Delivery and Microfluidic Applications

    E-Print Network [OSTI]

    Khandan, Omid

    2015-01-01

    Etching of Bulk Titanium for MEMS Applications. ” Journal ofMeng. 2012. “An Implantable MEMS Micropump System for Drugand Ellis Meng. 2009. “A Passive MEMS Drug Delivery Pump for

  5. Alcohol, Tobacco, and Other Drug Use in Illinois: Prevalence

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    Assessment Program. Rod R. Blagojevich, Governor #12;#12;Alcohol, Tobacco, and Other Drug Use in Illinois by the federal Office of Management and Budget. Theodora Binion-Taylor, Associate Director 100 West Randolph

  6. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  7. Feeling molecular forces: tactile feedback to enhance drug design 

    E-Print Network [OSTI]

    Williams, Jocylin Amber

    2013-02-22

    Molecular modeling is a vital component for structure-based drug design. Currently implemented technology combines data and graphics to give the user visual capabilities to assist in discovering possible binding arrangements. ...

  8. Stimuli Responsive Polymers for Enhanced Drug Release Applications

    E-Print Network [OSTI]

    Tam, Michael K. C.

    This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide- ...

  9. Device for wavelength-selective imaging

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2010-09-14

    An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.

  10. Predicting Crystallisation of Amorphous Drugs With Terahertz Spectroscopy

    E-Print Network [OSTI]

    Sibik, Juraj; Lobmann, Korbinian; Rades, Thomas; Zeitler, J. Axel

    2015-06-19

    solubility and dissolution rate.1,4 This can be exploited for applications such as in the pharmaceutical field to increase bioavailability of poorly soluble drugs when administered orally in the form of tablets or capsules. However, from a thermodynamic point... of amorphous systems, such as amorphous drugs, in order to prevent their crystallisation over the shelf life of a final product. Materials and Methods Materials. Paracetamol, indomethacin and flufenamic acid were obtained from Sigma- Aldrich (St. Louis, MA, USA...

  11. MULTISPECTRAL THERMAL IMAGER - OVERVIEW

    SciTech Connect (OSTI)

    P. WEBER

    2001-03-01

    The Multispectral Thermal Imager satellite fills a new and important role in advancing the state of the art in remote sensing sciences. Initial results with the full calibration system operating indicate that the system was already close to achieving the very ambitious goals which we laid out in 1993, and we are confident of reaching all of these goals as we continue our research and improve our analyses. In addition to the DOE interests, the satellite is tasked about one-third of the time with requests from other users supporting research ranging from volcanology to atmospheric sciences.

  12. Multiprocessor computing for images

    SciTech Connect (OSTI)

    Cantoni, V. ); Levialdi, S. )

    1988-08-01

    A review of image processing systems developed until now is given, highlighting the weak points of such systems and the trends that have dictated their evolution through the years producing different generations of machines. Each generation may be characterized by the hardware architecture, the programmability features and the relative application areas. The need for multiprocessing hierarchical systems is discussed focusing on pyramidal architectures. Their computational paradigms, their virtual and physical implementation, their programming and software requirements, and capabilities by means of suitable languages, are discussed.

  13. Superconductive imaging surface magnetometer

    DOE Patents [OSTI]

    Overton, Jr., William C. (Los Alamos, NM); van Hulsteyn, David B. (Santa Fe, NM); Flynn, Edward R. (Los Alamos, NM)

    1991-01-01

    An improved pick-up coil system for use with Superconducting Quantum Interference Device gradiometers and magnetometers involving the use of superconducting plates near conventional pick-up coil arrangements to provide imaging of nearby dipole sources and to deflect environmental magnetic noise away from the pick-up coils. This allows the practice of gradiometry and magnetometry in magnetically unshielded environments. One embodiment uses a hemispherically shaped superconducting plate with interior pick-up coils, allowing brain wave measurements to be made on human patients. another embodiment using flat superconducting plates could be used in non-destructive evaluation of materials.

  14. The Cosmic Background Imager

    E-Print Network [OSTI]

    S. Padin; M. C. Shepherd; J. K. Cartwright; R. G. Keeney; B. S. Mason; T. J. Pearson; A. C. S. Readhead; W. L. Schaal; J. Sievers; P. S. Udomprasert; J. K. Yamasaki; W. L. Holzapfel; J. E. Carlstrom; M. Joy; S. T. Myers; A. Otarola

    2001-10-05

    Design and performance details are given for the Cosmic Background Imager (CBI), an interferometer array that is measuring the power spectrum of fluctuations in the cosmic microwave background radiation (CMBR) for multipoles in the range 400 switching scheme is used to reject cross-talk and low-frequency pick-up in the signal processing system. The CBI has a 3-axis mount which allows the tracking platform to be rotated about the optical axis, providing improved (u,v) coverage and a powerful discriminant against false signals generated in the receiving electronics. Rotating the tracking platform also permits polarization measurements when some of the antennas are configured for the orthogonal polarization.

  15. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, H.O.; Martin, D.C.; Lampton, M.L.

    1983-07-26

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally. 15 figs.

  16. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, Hal O. (Berkeley, CA); Martin, Donn C. (Berkeley, CA); Lampton, Michael L. (Berkeley, CA)

    1983-01-01

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

  17. User Defined Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDidDevelopmentat LENA|Upcoming Purchasing andUser Defined Images User

  18. ImageJ

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation CurrentHenry Bellamy, Ph.D.FoodHydropower,PrincipalIdaho NationalAImageJ ImageJ

  19. TYPE OF DRUG DRUG NAMES STREET NAMES METHOD OF USE SYMPTOMS OF USE HAZARDS OF USE HASHISH OIL

    E-Print Network [OSTI]

    Johnson, Eric E.

    , disorientation, possible paranoia depending on strength of THC content Impaired memory, perception; interference, phenobarbital, pentobarbital, etc. Benzodiazepines: Valium, Xanax, Librium, Ativan, Dalmane, Serax, Restoril, convulsions, anxiety with withdrawal NARCOTICS & ANALOGS (related drugs produced in labs) Heroin, Morphine

  20. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01

    Politics: Emotion and Act Up’s Fight Against AIDS. Chicago,Henry K. 2006. “Bitter Fight Over Sweet Pot Treats: Drugto give the appearance that the fight against drugs wasn’t

  1. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01

    1993. “Cannabis: Legal Reform, Medicinal Use and HarmBruce 2004. "Drug Policy Reform and Its Detractors: TheRobins. 2003. Cannabis Law Reform in Canada: Is the “Saga of

  2. Fourier plane image amplifier

    DOE Patents [OSTI]

    Hackel, L.A.; Hermann, M.R.; Dane, C.B.; Tiszauer, D.H.

    1995-12-12

    A solid state laser is frequency tripled to 0.3 {micro}m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only about 1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power. 1 fig.

  3. Fourier plane image amplifier

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Hermann, Mark R. (San Ramon, CA); Dane, C. Brent (Livermore, CA); Tiszauer, Detlev H. (Tracy, CA)

    1995-01-01

    A solid state laser is frequency tripled to 0.3 .mu.m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only .about.1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power.

  4. Image-based occupancy sensor

    DOE Patents [OSTI]

    Polese, Luigi Gentile; Brackney, Larry

    2015-05-19

    An image-based occupancy sensor includes a motion detection module that receives and processes an image signal to generate a motion detection signal, a people detection module that receives the image signal and processes the image signal to generate a people detection signal, a face detection module that receives the image signal and processes the image signal to generate a face detection signal, and a sensor integration module that receives the motion detection signal from the motion detection module, receives the people detection signal from the people detection module, receives the face detection signal from the face detection module, and generates an occupancy signal using the motion detection signal, the people detection signal, and the face detection signal, with the occupancy signal indicating vacancy or occupancy, with an occupancy indication specifying that one or more people are detected within the monitored volume.

  5. Development of XFCT imaging strategy for monitoring the spatial distribution of platinum-based chemodrugs: Instrumentation and phantom validation

    SciTech Connect (OSTI)

    Kuang Yu [Department of Radiation Oncology and Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, California 94305-5847 and Medical Physics Program, University of Nevada, Las Vegas, Nevada 89154-3037 (United States); Pratx, Guillem; Bazalova, Magdalena; Qian Jianguo; Meng Bowen; Xing Lei [Department of Radiation Oncology and Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, California 94305-5847 (United States)

    2013-03-15

    Purpose: Developing an imaging method to directly monitor the spatial distribution of platinum-based (Pt) drugs at the tumor region is of critical importance for early assessment of treatment efficacy and personalized treatment. In this study, the authors investigated the feasibility of imaging platinum (Pt)-based drug distribution using x-ray fluorescence (XRF, a.k.a. characteristic x ray) CT (XFCT). Methods: A 5-mm-diameter pencil beam produced by a polychromatic x-ray source equipped with a tungsten anode was used to stimulate emission of XRF photons from Pt drug embedded within a water phantom. The phantom was translated and rotated relative to the stationary pencil beam in a first-generation CT geometry. The x-ray energy spectrum was collected for 18 s at each position using a cadmium telluride detector. The spectra were then used for the K-shell XRF peak isolation and sinogram generation for Pt. The distribution and concentration of Pt were reconstructed with an iterative maximum likelihood expectation maximization algorithm. The capability of XFCT to multiplexed imaging of Pt, gadolinium (Gd), and iodine (I) within a water phantom was also investigated. Results: Measured XRF spectrum showed a sharp peak characteristic of Pt with a narrow full-width at half-maximum (FWHM) (FWHM{sub K{alpha}1}= 1.138 keV, FWHM{sub K{alpha}2}= 1.052 keV). The distribution of Pt drug in the water phantom was clearly identifiable on the reconstructed XRF images. Our results showed a linear relationship between the XRF intensity of Pt and its concentrations (R{sup 2}= 0.995), suggesting that XFCT is capable of quantitative imaging. A transmission CT image was also obtained to show the potential of the approach for providing attenuation correction and morphological information. Finally, the distribution of Pt, Gd, and I in the water phantom was clearly identifiable in the reconstructed images from XFCT multiplexed imaging. Conclusions: XFCT is a promising modality for monitoring the spatial distribution of Pt drugs. The technique may be useful in tailoring tumor treatment regimen in the future.

  6. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Print Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying...

  7. Hybrid tomography for conductivity imaging

    E-Print Network [OSTI]

    T. Widlak; O. Scherzer

    2012-03-20

    Hybrid imaging techniques utilize couplings of physical modalities -- they are called hybrid, because, typically, the excitation and measurement quantities belong to different modalities. Recently there has been an enormous research interest in this area because these methods promise very high resolution. In this paper we give a review on hybrid tomography methods for \\emph{electrical conductivity} imaging. The reviewed imaging methods utilize couplings between electric, magnetic and ultrasound modalities. By this it is possible to perform high-resolution electrical impedance imaging and to overcome the low-resolution problem of electric impedance tomography.

  8. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    this technique has been especially popular in imaging such complex structures as aerogels and yeast cells. When applying the CDI technique to a magnetic system, the same...

  9. Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation

    E-Print Network [OSTI]

    Rabinowitz, Joshua D.

    Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation JOSHUA D. RABINOWITZ. A promising means of accelerating drug action is through rapid systemic drug administration via deep lung inhalation. The speed of pulmonary drug absorption depends on the site of aerosol deposition within the lung

  10. Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration

    E-Print Network [OSTI]

    Gelman, Andrew

    Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal seizures, and cerebrospinal fluid samples were collected for determination of drug concentration by high

  11. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  12. Drug-evoked synaptic plasticity and addictive behavior, a causal relationship?

    E-Print Network [OSTI]

    Fukai, Tomoki

    Drug-evoked synaptic plasticity and addictive behavior, a causal relationship? Christian Luescher principal interest is on drug reward and how exposure to addictive substances can change behavior in rodent models of addiction. "Drug-evoked synaptic plasticity" has emerged as a mechanism underlying drug

  13. Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring Sandro Carrara accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments monitoring of the patient's drug metabolism is essential as the metabolic pathways efficacy is highly

  14. DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT

    E-Print Network [OSTI]

    Pontrelli, Giuseppe

    DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT G. Pontrelli1 , F. de Monte2 , M. Prosi3 1. ABSTRACT The drug diffusion process through an arterial eluting stent is studied and a quantitative description for drug transport to evaluate feasibility of new drug delivery strategies

  15. Strategies to Target Pancreatic Cancer Stem Cells using Natural Killer Cells and Chemotherapeutic Drugs

    E-Print Network [OSTI]

    Lanzon, Caitlin Jean

    2015-01-01

    pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management

  16. Toponome Imaging System (TIS): imaging the proteome with functional resolution

    E-Print Network [OSTI]

    Cai, Long

    established as an automated imaging technology capable of high- performance, high-content applications at continuous intensity levels for the first time.TIS directly addresses protein-network architecture. A breakthrough in fluorescence imaging has been reported using multi-epitope-ligand cartography (MELC) technology

  17. MANSFIELD ET AL.: TRANSFORMING IMAGE COMPLETION 1 Transforming Image Completion

    E-Print Network [OSTI]

    Kohli, Pushmeet

    .K. Abstract Image completion is an important photo-editing task which involves synthetically filling a hole-of-the-art techniques. 1 Introduction Image completion is an important photo-editing task which involves synthetically the pixel traversal order critical. A number of user-driven [12] and intelligent [3] heuristics have been

  18. Application of Parallel Imaging to Murine Magnetic Resonance Imaging 

    E-Print Network [OSTI]

    Chang, Chieh-Wei 1980-

    2012-09-21

    . This dissertation describes foundational level work to enable parallel imaging of mice on a 4.7 Tesla/40 cm bore research scanner. Reducing the size of the hardware setup associated with typical parallel imaging was an integral part of achieving the work, as animal...

  19. Nonlinear digital imaging

    E-Print Network [OSTI]

    Lu, Jen-Tang; Fleischer, Jason W

    2015-01-01

    Nonlinear imaging systems can surpass the limits of linear optics, but to date they have all relied on physical media (e.g. crystals) to work. These materials are all constrained by their physical properties, such as frequency selectivity, environmental sensitivity, time behavior, and fixed nonlinear response. Here, we show that electro-optic spatial light modulators (SLMs) can take the place of traditional nonlinear media, provided that there is a feedback between the shape of the object and the pattern on the modulator. This feedback creates a designer illumination that generalizes the field of adaptive optics to include object-dependent patterns. Unlike physical media, the SLM response can provide arbitrary mathematical functions, operate over broad bandwidths at high speeds, and work equally well at high power and single-photon levels. We demonstrate the method experimentally for both coherent and incoherent light.

  20. Processing Visual Images

    SciTech Connect (OSTI)

    Litke, Alan (UC Santa Cruz) [UC Santa Cruz

    2006-03-27

    The back of the eye is lined by an extraordinary biological pixel detector, the retina. This neural network is able to extract vital information about the external visual world, and transmit this information in a timely manner to the brain. In this talk, Professor Litke will describe a system that has been implemented to study how the retina processes and encodes dynamic visual images. Based on techniques and expertise acquired in the development of silicon microstrip detectors for high energy physics experiments, this system can simultaneously record the extracellular electrical activity of hundreds of retinal output neurons. After presenting first results obtained with this system, Professor Litke will describe additional applications of this incredible technology.

  1. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

    E-Print Network [OSTI]

    Xu, Jinghai J.

    Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration ...

  2. Imaging synthetic aperture radar

    DOE Patents [OSTI]

    Burns, Bryan L. (Tijeras, NM); Cordaro, J. Thomas (Albuquerque, NM)

    1997-01-01

    A linear-FM SAR imaging radar method and apparatus to produce a real-time image by first arranging the returned signals into a plurality of subaperture arrays, the columns of each subaperture array having samples of dechirped baseband pulses, and further including a processing of each subaperture array to obtain coarse-resolution in azimuth, then fine-resolution in range, and lastly, to combine the processed subapertures to obtain the final fine-resolution in azimuth. Greater efficiency is achieved because both the transmitted signal and a local oscillator signal mixed with the returned signal can be varied on a pulse-to-pulse basis as a function of radar motion. Moreover, a novel circuit can adjust the sampling location and the A/D sample rate of the combined dechirped baseband signal which greatly reduces processing time and hardware. The processing steps include implementing a window function, stabilizing either a central reference point and/or all other points of a subaperture with respect to doppler frequency and/or range as a function of radar motion, sorting and compressing the signals using a standard fourier transforms. The stabilization of each processing part is accomplished with vector multiplication using waveforms generated as a function of radar motion wherein these waveforms may be synthesized in integrated circuits. Stabilization of range migration as a function of doppler frequency by simple vector multiplication is a particularly useful feature of the invention; as is stabilization of azimuth migration by correcting for spatially varying phase errors prior to the application of an autofocus process.

  3. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  4. The use of carbon stable isotope ratios in drugs characterization

    SciTech Connect (OSTI)

    Magdas, D. A., E-mail: gabriela.cristea@itim-cj.ro; Cristea, G., E-mail: gabriela.cristea@itim-cj.ro; Bot, A., E-mail: gabriela.cristea@itim-cj.ro; Mirel, V., E-mail: gabriela.cristea@itim-cj.ro [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Str., 400293 Cluj-Napoca (Romania)

    2013-11-13

    Isotopic Ratio Mass Spectrometry (IRMS) is an effective toll to be used for drug product authentication. The isotopic composition could be used to assist in the differentiation between batches of drugs and assist in the identification of counterfeit materials on the market. Only two factors affect the isotopic ratios in pharmaceutical components: the isotopic composition of the raw materials and the synthetic processes performed upon them. Counterfeiting of pharmaceutical drugs threatens consumer confidence in drug products companies' economical well-being. In this preliminary study, the analyzed samples consist in two types of commercially available analgesics, which were purchases from Romanian pharmacies. Differences in ?{sup 13}C between batches from ?29.7 to ?31.6% were observed, demonstrating that this method can be used to differentiate among individual drug batches and subsequently identify counterfeits on the market. On the other hand, carbon isotopic ratios differences among producers were recorded, the variations being between ?31.3 to ?34.9% for the same type of analgesic, but from different manufactures.

  5. Image Processing Feb. 26, 2013

    E-Print Network [OSTI]

    Erdem, Erkut

    : Partial Differential Equations and the Calculus ofVariations, G. Aubert and P. Kornprobst, 2nd Edition later #12;About BIL717 · This course provides a comprehensive overview of fundamental topics in image ForVision And Image Processing, Edited by A. Blake, P. Kohli and C. Rother, MIT Press, 2011 #12

  6. Astronomical Image and Signal Processing

    E-Print Network [OSTI]

    Starck, Jean-Luc

    of the amount of information in the image. Shannon [38], in the framework of communication theory, suggested and where, and the statistical one, which gives a quantity rela- tive to the amount of information. Another to measure the informa- tion in an astronomical image, in both a statistical and a deterministic way

  7. Video surveillance with speckle imaging

    DOE Patents [OSTI]

    Carrano, Carmen J. (Livermore, CA); Brase, James M. (Pleasanton, CA)

    2007-07-17

    A surveillance system looks through the atmosphere along a horizontal or slant path. Turbulence along the path causes blurring. The blurring is corrected by speckle processing short exposure images recorded with a camera. The exposures are short enough to effectively freeze the atmospheric turbulence. Speckle processing is used to recover a better quality image of the scene.

  8. Simultaneous acquisition of differing image types

    DOE Patents [OSTI]

    Demos, Stavros G

    2012-10-09

    A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. A method in one embodiment includes receiving an image from an image forming device; decomposing the image formed by the image forming device into multiple component parts based on type of imaging; receiving the component parts of the image; and outputting image information based on the component parts of the image. Additional systems and methods are presented.

  9. In Vitro Evolutionary Dynamics of C. albicans during Adaptation to Fluocnazole 

    E-Print Network [OSTI]

    Huang, Mian

    2012-10-19

    Page 1 Targets of Antifungal Agents and Drug-Resistant Mechanims in Candida albicans ................................................................ 17 2 Steps in the Mating of Candida albicans..., 112). FIG. 1. Targets of Antifungal Agents (a) and Drug-Resistant Mechanims (b) in Candida albicans. Grey lettering indicates mutated proteins and bold lettering indicates protein overexpression. 5-FU, 5- fluorouracil; 5-FUMP, 5...

  10. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  11. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  12. Dynamic instability of microtubules: effect of catastrophe-suppressing drugs

    E-Print Network [OSTI]

    Pankaj Kumar Mishra; Ambarish Kunwar; Sutapa Mukherji; Debashish Chowdhury

    2007-02-21

    Microtubules are stiff filamentary proteins that constitute an important component of the cytoskeleton of cells. These are known to exhibit a dynamic instability. A steadily growing microtubule can suddenly start depolymerizing very rapidly; this phenomenon is known as ``catastrophe''. However, often a shrinking microtubule is ``rescued'' and starts polymerizing again. Here we develope a model for the polymerization-depolymerization dynamics of microtubules in the presence of {\\it catastrophe-suppressing drugs}. Solving the dynamical equations in the steady-state, we derive exact analytical expressions for the length distributions of the microtubules tipped with drug-bound tubulin subunits as well as those of the microtubules, in the growing and shrinking phases, tipped with drug-free pure tubulin subunits. We also examine the stability of the steady-state solutions.

  13. X-ray Spectroscopy for Quality Control of Chemotherapy Drugs

    SciTech Connect (OSTI)

    Greaves, E. D.; Barros, H.; Bermudez, J.; Sajo-Bohus, L.; Angeli-Greaves, M.

    2007-10-26

    We develop a method, employing Compton peak standardization and the use of matrix-matched spiked samples with Total Reflection X-ray Fluorescence (TXRF), for the determination of platinum plasma concentrations of patients undergoing chemotherapy with Pt-bearing drugs. Direct blood plasma analysis attains Pt detection limits of 70 ng/ml. Measurement results of prescribed drug doses are compared to achieved blood Pt concentrations indicating a lack of expected correlations. Direct analysis of Pt-containing infused drugs from a variety of suppliers indicates cases of abnormal concentrations which raises quality control issues. We demonstrate the potential usefulness of the method for pharmacokinetic studies or for routine optimization and quality control of Pt chemotherapy treatments.

  14. Controlling drug delivery across the placenta: A commentary

    E-Print Network [OSTI]

    Audus, Kenneth L.

    1999-01-01

    Audus, K.L. (1999) Controlling drug delivery across the placenta: A commentary. Eur. J. Pharm. Sci. 8, 161-165. PMID: 10379038. Publisher’s official version: http://dx.doi.org/10.1016/S0928-0987(99)00031-7. Open Access version: http... document contains the author’s accepted manuscript. For the publisher’s version, see the link in the header of this document.] Paper citation: Audus, K.L. (1999) Controlling drug delivery across the placenta: A commentary. Eur. J. Pharm. Sci. 8...

  15. Pixel-level Image Fusion Algorithms for Multi-camera Imaging System

    E-Print Network [OSTI]

    Abidi, Mongi A.

    Pixel-level Image Fusion Algorithms for Multi-camera Imaging System A Thesis Presented of image fusion technologies in the multi sensor image fusion system and applications. With specific focus on pixel level image fusion, the process after the image registration is processed, we develop graphic user

  16. Reaction product imaging

    SciTech Connect (OSTI)

    Chandler, D.W. [Sandia National Laboratories, Livermore, CA (United States)

    1993-12-01

    Over the past few years the author has investigated the photochemistry of small molecules using the photofragment imaging technique. Bond energies, spectroscopy of radicals, dissociation dynamics and branching ratios are examples of information obtained by this technique. Along with extending the technique to the study of bimolecular reactions, efforts to make the technique as quantitative as possible have been the focus of the research effort. To this end, the author has measured the bond energy of the C-H bond in acetylene, branching ratios in the dissociation of HI, the energetics of CH{sub 3}Br, CD{sub 3}Br, C{sub 2}H{sub 5}Br and C{sub 2}H{sub 5}OBr dissociation, and the alignment of the CD{sub 3} fragment from CD{sub 3}I photolysis. In an effort to extend the technique to bimolecular reactions the author has studied the reaction of H with HI and the isotopic exchange reaction between H and D{sub 2}.

  17. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W. (East Moriches, NY); Brill, A. Bertrand (Shoreham, NY); Bizais, Yves J. C. (Upton, NY); Rowe, R. Wanda (Upton, NY); Zubal, I. George (Upton, NY)

    1986-01-01

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  18. Image indexing using color correlograms

    DOE Patents [OSTI]

    Huang, Jing (Ossining, NY); Kumar, Shanmugasundaram Ravi (San Jose, CA); Mitra, Mandar (Calcutta, IN); Zhu, Wei-Jing (Ossining, NY)

    2001-01-01

    A color correlogram is a three-dimensional table indexed by color and distance between pixels which expresses how the spatial correlation of color changes with distance in a stored image. The color correlogram may be used to distinguish an image from other images in a database. To create a color correlogram, the colors in the image are quantized into m color values, c.sub.i . . . c.sub.m. Also, the distance values k.epsilon.[d] to be used in the correlogram are determined where [d] is the set of distances between pixels in the image, and where dmax is the maximum distance measurement between pixels in the image. Each entry (i, j, k) in the table is the probability of finding a pixel of color c.sub.i at a selected distance k from a pixel of color c.sub.i. A color autocorrelogram, which is a restricted version of the color correlogram that considers color pairs of the form (i,i) only, may also be used to identify an image.

  19. Imaging algorithms in radio interferometry

    E-Print Network [OSTI]

    R. J. Sault; T. A. Oosterloo

    2007-01-08

    The paper reviews progress in imaging in radio interferometry for the period 1993-1996. Unlike an optical telescope, the basic measurements of a radio interferometer (correlations between antennas) are indirectly related to a sky brightness image. In a real sense, algorithms and computers are the lenses of a radio interferometer. In the last 20 years, whereas interferometer hardware advances have resulted in improvements of a factor of a few, algorithm and computer advances have resulted in orders of magnitude improvement in image quality. Developing these algorithms has been a fruitful and comparatively inexpensive method of improving the performance of existing telescopes, and has made some newer telescopes possible. In this paper, we review recent developments in the algorithms used in the imaging part of the reduction process. What constitutes an `imaging algorithm'? Whereas once there was a steady `forward' progression in the reduction process of editing, calibrating, transforming and, finally, deconvolving, this is no longer true. The introduction of techniques such as self-calibration, and algorithms that go directly from visibilities to final images, have made the dividing lines less clear. Although we briefly consider self-calibration, for the purposes of this paper calibration issues are generally excluded. Most attention will be directed to the steps which form final images from the calibrated visibilities.

  20. Structured representation of images for language generation and image retrieval 

    E-Print Network [OSTI]

    Elliott, Desmond

    2015-06-29

    A photograph typically depicts an aspect of the real world, such as an outdoor landscape, a portrait, or an event. The task of creating abstract digital representations of images has received a great deal of attention ...

  1. Image Storage in Hot Vapors

    E-Print Network [OSTI]

    L. Zhao; T. Wang; Y. Xiao; S. F. Yelin

    2007-10-22

    We theoretically investigate image propagation and storage in hot atomic vapor. A $4f$ system is adopted for imaging and an atomic vapor cell is placed over the transform plane. The Fraunhofer diffraction pattern of an object in the object plane can thus be transformed into atomic Raman coherence according to the idea of ``light storage''. We investigate how the stored diffraction pattern evolves under diffusion. Our result indicates, under appropriate conditions, that an image can be reconstructed with high fidelity. The main reason for this procedure to work is the fact that diffusion of opposite-phase components of the diffraction pattern interfere destructively.

  2. Imaging Lithium Air Electrodes | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutron Imaging Reveals Lithium Distribution in Lithium-Air Electrodes Agatha Bardoel - January 01, 2013 Image produced by neutron-computed tomography. The next step in...

  3. Nanoscale Chemical Imaging of a Working Catalyst

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoscale Chemical Imaging of a Working Catalyst Nanoscale Chemical Imaging of a Working Catalyst Print Wednesday, 28 January 2009 00:00 The heterogeneous catalysts used in most...

  4. Optimal Learning for Drug Discovery in Ewing's Sarcoma Diana Negoescu

    E-Print Network [OSTI]

    Powell, Warren B.

    (molecules) to dramatically reduce the number of molecular tests required, but has heavy computational the sequence of molecular compounds to test in drug discovery. Beginning with a base compound, we consider. The problem of choosing the molecules to test to maximize the expected quality of the best compound discovered

  5. Metabolic Regulation and Anticancer Drug Resistance in the Yeast

    E-Print Network [OSTI]

    Metabolic Regulation and Anticancer Drug Resistance in the Yeast Saccharomyces cerevisiae Mattias-91-576-8059-4 © 2014 Mattias Carlsson, Uppsala Print: SLU Service/Repro, Uppsala 2014 #12;Metabolic Regulation regulation by the yeast Rph1p protein, a zinc finger transcription factor which also contains a jmjC domain

  6. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  7. University of Alberta Sexual Assault Centre Alcohol & Drug-Facilitated

    E-Print Network [OSTI]

    Machel, Hans

    University of Alberta Sexual Assault Centre Alcohol & Drug-Facilitated Sexual Assault In a survey conducted at the University of Alberta, it was found that over half of the sexual assaults experienced process involves remembering and working through the memories, #12;University of Alberta Sexual Assault

  8. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    ,[2] which were genetically engineered to universally express luciferase, provides a rapid readout of the body by using a modified b-actin promoter.[4] As the majority of luciferin is cleared from the body nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA

  9. Higher Prices from Entry: Pricing of Brand-Name Drugs

    E-Print Network [OSTI]

    Perloff, Jeffrey M.

    Higher Prices from Entry: Pricing of Brand-Name Drugs Jeffrey M. Perloff* Valerie Y. Suslow** Paul and starts selling a spatially-differentiated product, the prices of existing products may rise due to a better match between consumers and products. Entry may have three unusual effects. First, the new price

  10. Higher Prices from Entry: Pricing of Brand-Name Drugs

    E-Print Network [OSTI]

    Perloff, Jeffrey M.

    Higher Prices from Entry: Pricing of Brand-Name Drugs Jeffrey M. Perloffa Valerie Y. Suslowb,* Paul product, the prices of existing and new products may be higher than the incumbent's original price due to a better match between consumers and products. In other words, the average price in the market can rise

  11. Research Commentary An ``Omics'' View of Drug Development

    E-Print Network [OSTI]

    Rubin, Daniel L.

    Informatics, Stanford University Stanford, California Strategy, Management and Health Policy Enabling Postmarketing Phase IV ABSTRACT The pharmaceutical industry cannot be blamed for having a love/hate relationship, pharmaceutical developers and regulators have been careful in creating strategies for using genetics in drug

  12. Image credit: Dreamstime Technology for

    E-Print Network [OSTI]

    through development of superconducting magnet technology. Without that research today's high- resolutionImage credit: Dreamstime Technology for research saves lives Technology developed to advance STFC in particle physics technology not only supported important experiments at CERN but pioneered early

  13. Quantum ghost imaging through turbulence

    E-Print Network [OSTI]

    Dixon, P. Ben

    We investigate the effect of turbulence on quantum ghost imaging. We use entangled photons and demonstrate that for a specific experimental configuration the effect of turbulence can be greatly diminished. By decoupling ...

  14. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    28 March 2012 00:00 Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying...

  15. Motion Estimation from Disparity Images

    E-Print Network [OSTI]

    Demirdjian, D.

    2001-05-07

    A new method for 3D rigid motion estimation from stereo is proposed in this paper. The appealing feature of this method is that it directly uses the disparity images obtained from stereo matching. We assume that the stereo ...

  16. Methods for functional brain imaging

    E-Print Network [OSTI]

    Witzel, Thomas, Ph. D. Massachusetts Institute of Technology

    2011-01-01

    Magnetic resonance imaging (MRI) has demonstrated the potential for non-invasive mapping of structure and function (fMRI) in the human brain. In this thesis, we propose a series of methodological developments towards ...

  17. High speed imaging television system

    DOE Patents [OSTI]

    Wilkinson, William O. (Silver Spring, MD); Rabenhorst, David W. (Silver Spring, MD)

    1984-01-01

    A television system for observing an event which provides a composite video output comprising the serially interlaced images the system is greater than the time resolution of any of the individual cameras.

  18. Imaging Liquids Using Microfluidic Cells

    SciTech Connect (OSTI)

    Yu, Xiao-Ying; Liu, Bingwen; Yang, Li

    2013-05-10

    Chemistry occurring in the liquid and liquid surface is important in many applications. Chemical imaging of liquids using vacuum based analytical techniques is challenging due to the difficulty in working with liquids with high volatility. Recent development in microfluidics enabled and increased our capabilities to study liquid in situ using surface sensitive techniques such as electron microscopy and spectroscopy. Due to its small size, low cost, and flexibility in design, liquid cells based on microfluidics have been increasingly used in studying and imaging complex phenomena involving liquids. This paper presents a review of microfluidic cells that were developed to adapt to electron microscopes and various spectrometers for in situ chemical analysis and imaging of liquids. The following topics will be covered including cell designs, fabrication techniques, unique technical features for vacuum compatible cells, and imaging with electron microscopy and spectroscopy. Challenges are summarized and recommendations for future development priority are proposed.

  19. Imaging atoms in 3-D

    ScienceCinema (OSTI)

    Ercius, Peter

    2014-06-27

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  20. Imaging atoms in 3-D

    SciTech Connect (OSTI)

    Ercius, Peter

    2013-10-31

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  1. Thomas Jefferson: image and ideology 

    E-Print Network [OSTI]

    Wilson, Gaye N. S. B.

    2012-11-30

    This thesis explores the public image of Thomas Jefferson as recorded in his major life portraits. It consults the traditions that surrounded eighteenth-century portraiture and the history of the portrait as a means of ...

  2. Computational time-resolved imaging

    E-Print Network [OSTI]

    Kirmani, Ghulam A. (Ghulam Ahmed)

    2015-01-01

    Classical photography uses steady-state illumination and light sensing with focusing optics to capture scene reflectivity as images; temporal variations of the light field are not exploited. This thesis explores the use ...

  3. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, M.A.; Tsang, B.W.

    1994-06-28

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

  4. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, Mark A. (West Lafayette, IN); Tsang, Brenda W. (Lafayette, IN)

    1994-01-01

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.

  5. Range determination for scannerless imaging

    DOE Patents [OSTI]

    Muguira, Maritza Rosa (Albuquerque, NM); Sackos, John Theodore (Albuquerque, NM); Bradley, Bart Davis (Albuquerque, NM); Nellums, Robert (Albuquerque, NM)

    2000-01-01

    A new method of operating a scannerless range imaging system (e.g., a scannerless laser radar) has been developed. This method is designed to compensate for nonlinear effects which appear in many real-world components. The system operates by determining the phase shift of the laser modulation, which is a physical quantity related physically to the path length between the laser source and the detector, for each pixel of an image.

  6. Noise Reduction in CMOS Image Sensors for High Quality Imaging: The Autocorrelation Function Filter on Burst Image Sequences

    E-Print Network [OSTI]

    Nielsen, Frank

    Noise Reduction in CMOS Image Sensors for High Quality Imaging: The Autocorrelation Function Filter-hiro@waseda.jp Abstract We propose a new method for image noise detection and reduction in complementary metal oxide semi- conductor (CMOS) image sensors inspired from audio noise cancelling techniques. Our algorithm is based

  7. High speed imager test station

    DOE Patents [OSTI]

    Yates, G.J.; Albright, K.L.; Turko, B.T.

    1995-11-14

    A test station enables the performance of a solid state imager (herein called a focal plane array or FPA) to be determined at high image frame rates. A programmable waveform generator is adapted to generate clock pulses at determinable rates for clock light-induced charges from a FPA. The FPA is mounted on an imager header board for placing the imager in operable proximity to level shifters for receiving the clock pulses and outputting pulses effective to clock charge from the pixels forming the FPA. Each of the clock level shifters is driven by leading and trailing edge portions of the clock pulses to reduce power dissipation in the FPA. Analog circuits receive output charge pulses clocked from the FPA pixels. The analog circuits condition the charge pulses to cancel noise in the pulses and to determine and hold a peak value of the charge for digitizing. A high speed digitizer receives the peak signal value and outputs a digital representation of each one of the charge pulses. A video system then displays an image associated with the digital representation of the output charge pulses clocked from the FPA. In one embodiment, the FPA image is formatted to a standard video format for display on conventional video equipment. 12 figs.

  8. High speed imager test station

    DOE Patents [OSTI]

    Yates, George J. (Santa Fe, NM); Albright, Kevin L. (Los Alamos, NM); Turko, Bojan T. (Moraga, CA)

    1995-01-01

    A test station enables the performance of a solid state imager (herein called a focal plane array or FPA) to be determined at high image frame rates. A programmable waveform generator is adapted to generate clock pulses at determinable rates for clock light-induced charges from a FPA. The FPA is mounted on an imager header board for placing the imager in operable proximity to level shifters for receiving the clock pulses and outputting pulses effective to clock charge from the pixels forming the FPA. Each of the clock level shifters is driven by leading and trailing edge portions of the clock pulses to reduce power dissipation in the FPA. Analog circuits receive output charge pulses clocked from the FPA pixels. The analog circuits condition the charge pulses to cancel noise in the pulses and to determine and hold a peak value of the charge for digitizing. A high speed digitizer receives the peak signal value and outputs a digital representation of each one of the charge pulses. A video system then displays an image associated with the digital representation of the output charge pulses clocked from the FPA. In one embodiment, the FPA image is formatted to a standard video format for display on conventional video equipment.

  9. THERMOACOUSTIC TOMOGRAPHY ARISING IN BRAIN IMAGING ...

    E-Print Network [OSTI]

    2011-02-21

    THERMOACOUSTIC TOMOGRAPHY ARISING IN BRAIN IMAGING. PLAMEN STEFANOV AND GUNTHER UHLMANN. ABSTRACT. We study the mathematical ...

  10. Image Based Gisting in CLIR Mark Sanderson

    E-Print Network [OSTI]

    Sanderson, Mark

    from the Rosch [1] paper. These search terms were entered into the Google Image search engine in order the ability of subjects to derive the search term that might have been used to return a set of images from on subjects' abilities in this respect. Search terms were defined and images found using an online image

  11. The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

    E-Print Network [OSTI]

    Day, Troy

    milieu where in-host competition can radically alter the fitness costs and benefits of re- sistance, there is near-universal agreement that combination drug therapy, the coadministration of drugs with unrelated

  12. Impact of flow pulsatility on arterial drug distribution in stent-based therapy

    E-Print Network [OSTI]

    O'Brien, Caroline C.

    Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors ...

  13. Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery

    E-Print Network [OSTI]

    Tzafriri, A. R.

    Background:? Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies ...

  14. Medical data mining : improving information accessibility using online patient drug reviews

    E-Print Network [OSTI]

    Li, Yueyang Alice

    2011-01-01

    We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

  15. The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies

    E-Print Network [OSTI]

    DeMonaco, Harold J.

    2005-09-23

    Objective: To determine, through a review of the medical literature and author contact, the role of clinicians in the discovery of off label use of Food and Drug Administration approved prescription drugs.

  16. FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

  17. DEVELOPMENTAL REGULATION OF THE DRUG-PROCESSING GENOME IN MOUSE LIVER

    E-Print Network [OSTI]

    Cui, Yue

    2010-07-29

    Despite the recent progress in understanding the expression patterns and regulatory mechanisms of drug-processing genes, namely phase-I and -II drug metabolizing enzymes and transporters in adults, very little is known of ...

  18. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil 

    E-Print Network [OSTI]

    Fonseca, Elize Massard da

    2011-12-09

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was introduced in 1999. This policy...

  19. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil 

    E-Print Network [OSTI]

    Fonseca, Elize Massard

    2012-06-29

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was ...

  20. The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery 

    E-Print Network [OSTI]

    Neerman, Michael Frederick

    2005-08-29

    Often associated with chemotherapy are the dangerous and sometimes lifethreatening side effects towards non-cancerous tissue that can occur while on such drug regimens. The design and utilization of macromolecular drug delivery vehicles is gaining...

  1. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  2. Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON

    E-Print Network [OSTI]

    Fernandez, Eduardo

    Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

  3. Survival of multi-drug resistant enteropathogenic Escherichia coli and Salmonella paratyphi in Vembanadu

    E-Print Network [OSTI]

    Mazumder, Asit

    Survival of multi-drug resistant enteropathogenic Escherichia coli and Salmonella paratyphi the survival response of multi-drug resistant enteropathogenic Escherichia coli and Salmonella paratyphi- otypes of Escherichia coli, Salmonella enterica typhi and paratyphi are highly endemic to India

  4. Changes in the characteristics of approved New Drug Applications for antihypertensives

    E-Print Network [OSTI]

    MacNeil, John Simon Howe

    2007-01-01

    In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

  5. Interpretation of HRTEM images by image simulation: An introduction to theory and practice

    SciTech Connect (OSTI)

    O`Keefe, M.A.

    1994-08-01

    This tutorial describes the use of image simulation as an aid to interpretation of high-resolution transmission electron microscope images. Topics include some image processing as well as image simulation. Image processing is the manipulation of experimental images in order to extract some desired information. Image simulation is the generation of a computed or simulated image from a model structure. It requires a detailed knowledge of the process of image formation in the high-resolution transmission electron microscope. This tutorial concentrates on image simulation, with examples of image processing appearing only as required as illustrations. Because this is an introduction, the theory of image simulation is described, but not explored in depth. The practice of image simulation is covered in sufficient detail to enable the student to understand the functions of the various steps in the computations, and the parameters necessary for their evaluation.

  6. A NOVEL DNA-BASED MICROFLUORIMETRIC METHOD TO EVALUATE ANTIMALARIAL DRUG ACTIVITY

    E-Print Network [OSTI]

    Coley, Phyllis

    -plasmodial drugs, including quinine and artemisinin,7,8 many of which are derived from biodiversity-rich developing

  7. Method for removing RFI from SAR images

    DOE Patents [OSTI]

    Doerry, Armin W.

    2003-08-19

    A method of removing RFI from a SAR by comparing two SAR images on a pixel by pixel basis and selecting the pixel with the lower magnitude to form a composite image. One SAR image is the conventional image produced by the SAR. The other image is created from phase-history data which has been filtered to have the frequency bands containing the RFI removed.

  8. A Model of Image Representation and Indexing in Image Database Systems \\Lambda

    E-Print Network [OSTI]

    Krovi, Venkat

    A Model of Image Representation and Indexing in Image Database Systems \\Lambda G. Sheikholeslami Buffalo, NY 14260 Abstract Image database systems need to be built to support effective and efficient­oriented image decomposition structures to be used as a fundamental data model for representing image content

  9. Interpretation of electron holographic phase images and defocused bright-field images of nanocarbon field emitters

    E-Print Network [OSTI]

    Dunin-Borkowski, Rafal E.

    a corresponding out-of-focus image recorded from a similar wire [2]. These images cannot be interpreted usingInterpretation of electron holographic phase images and defocused bright-field images of nanocarbon field, image simulation Electron holography is well suited to the investigation of electric and magnetic

  10. The encapsulation of hydrophobic drugs in Pluronic F127 micelles: the effects of drug hydrophobicity, solution temperature and pH

    E-Print Network [OSTI]

    Rajib Basak; Ranjini Bandyopadhyay

    2014-06-27

    Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo- Scanning Electron Microscopy and Dynamic Light Scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution. The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules. The hydration of the micellar core at lower temperatures is verified using fluorescence measurements. Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.

  11. A HYBRID INTELLIGENT SYSTEM FOR FORMULATION OF BCS CLASS II DRUGS IN HARD GELATIN CAPSULES

    E-Print Network [OSTI]

    Peng, Yun

    A HYBRID INTELLIGENT SYSTEM FOR FORMULATION OF BCS CLASS II DRUGS IN HARD GELATIN CAPSULES Gunjan in hard gelatin cap- sules. Several significant challenges are involved in drug- formulation: the active of drug formulations for hard gelatin capsules can present significant challenges [4]. Some

  12. CABM Symposium Applications of NMR to structure-based drug design in structural

    E-Print Network [OSTI]

    Powers, Robert

    CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need

  13. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to evaluate ligand binding with an obvious utility in structure-based drug discovery and design.7-10 The "SAR to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug

  14. Efficient algorithms for a scheduling problem and its applications to illicit drug market crackdowns

    E-Print Network [OSTI]

    Krovi, Venkat

    scheduling problem. By duality we transform a special case of the drug market crackdown scheduling problemEfficient algorithms for a scheduling problem and its applications to illicit drug market for the general case of the drug market crackdown scheduling problem with monomial cost functions. key words: job

  15. Drugs: education, prevention and policy, June 2013; 20(3): 184194 Copyright 2013 Informa UK Ltd.

    E-Print Network [OSTI]

    Triolo, Livio

    2013 Drugs: education, prevention and policy, June 2013; 20(3): 184­194 Copyright ß 2013 Informa UK Ltd. ISSN: 0968-7637 print/1465-3370 online DOI: 10.3109/09687637.2012.750274 Drug user dynamics: A compartmental model of drug users for scenario analyses Mario Santoro1 , Livio Triolo1 , & Carla Rossi2 1

  16. DETERMINATION OF BOVINE SERUM ALBUMIN CONJUGATED DRUGS BY IMMOBILIZATION AS MICROARRAYS AND

    E-Print Network [OSTI]

    Zhu, Xiangdong

    DETERMINATION OF BOVINE SERUM ALBUMIN CONJUGATED DRUGS BY IMMOBILIZATION AS MICROARRAYS AND OBLIQUE, California, USA & Human serum is a mixture of various proteins which may interact with drugs. Therefore. The experimental results show that the binding affinities between most of the drugs and their antibodies were

  17. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  18. Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance

    E-Print Network [OSTI]

    Schnaufer, Achim

    Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance between two of the major classes of drug used in the treat- ment of African as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs. African

  19. Encapsulation of Hydrophobic Drugs in a Copolymer: Glass Transition Behavior and Miscibility Evaluation

    E-Print Network [OSTI]

    North Texas, University of

    Encapsulation of Hydrophobic Drugs in a Copolymer: Glass Transition Behavior and Miscibility, Greece The knowledge of glass transition temperatures Tg in drug + polymer systems is indispensable for drug encapsulation. Tg values as a function of composition make possible the determination whether

  20. Drug delivery systems based on sugar-macromolecule conjugates Benjamin G Davis* & Mark A Robinson

    E-Print Network [OSTI]

    Davis, Ben G.

    Drug delivery systems based on sugar-macromolecule conjugates Benjamin G Davis* & Mark A Robinson in Drug Discovery & Development 2002 5(2): 279-288 PharmaPress Ltd ISSN 1367-6733 The specificity-tuning of active drug delivery through their great ability to undergo site- specific modification

  1. Journal of Chromatography A, 1116 (2006) 193203 Determination of acidic drugs and caffeine in municipal

    E-Print Network [OSTI]

    Mazumder, Asit

    2006-01-01

    Journal of Chromatography A, 1116 (2006) 193­203 Determination of acidic drugs and caffeine of both sample preparation and instrumental techniques for analysis of such acidic drugs and Oasis HLB SPE cartridges were used to pre-concentrate samples for acidic drugs and caffeine

  2. DRUGS OF ABUSE IN URBANDRUGS OF ABUSE IN URBAN GROUNDWATER. A CASE STUDY

    E-Print Network [OSTI]

    Politècnica de Catalunya, Universitat

    DRUGS OF ABUSE IN URBANDRUGS OF ABUSE IN URBAN GROUNDWATER. A CASE STUDY: BARCELONA. Anna Jurado J, J., Tubau, I.,Pujades, E., Postigo, C., Lopez de Alda, M., Barceló, D. (2012). "Drugs of abuse Are not efficiently removed in WWTP's. Some of them are endocrine disrupters. Pharmaceuticals Hormones Drugs of abuse

  3. Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs

    E-Print Network [OSTI]

    Ma, Lena

    Raspberry derived mesoporous carbon-tubules and fixed-bed adsorption of pharmaceutical drugs Shashi Department, University of Florida, Gainesville, FL 32611-0290, USA 1. Introduction Pharmaceutical drugs (PD­water partition coefficient Pharmaceutical drugs A B S T R A C T Novel mesoporous carbon-tubules were prepared

  4. University Policy Statement for Students concerning Drugs Page 1 of 3

    E-Print Network [OSTI]

    Banaji,. Murad

    University Policy Statement for Students concerning Drugs Page 1 of 3 THE UNIVERSITY OF KENT University Policy Statement for Students concerning Drugs (Substance Misuse) 1. Purpose (i) The University responsibility to promote good health by raising awareness of the risks of drug misuse. (iii) The University

  5. This ICBG program links the discovery of drugs and genes for agriculture with biodiversity conservation.

    E-Print Network [OSTI]

    Coley, Phyllis

    ABSTRACT This ICBG program links the discovery of drugs and genes for agriculture with biodiversity of Panama's scientific infrastructure for drug and gene discovery, the training of Panamanian scientists in the short- and long-term. INTRODUCTION Over 50% of the most common prescription drugs orig- inate from

  6. STAR Images: Image gallery from the Solenoidal Tracker at RHIC

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The primary physics task of STAR is to study the formation and characteristics of the quark-gluon plasma (QGP), a state of matter believed to exist at sufficiently high energy densities. STAR consists of several types of detectors, each specializing in detecting certain types of particles or characterizing their motion. These detectors allow final statements to be made about the collision. The gallery of STAR images makes available a small collection of event-generated images from Gold-Beam experiments, a simulation of TCP Drift, and a library of STAR instrument and construction photos.

  7. Predicting drug metabolism: experiment and/or computation?

    E-Print Network [OSTI]

    Kirchmair, Johannes; Göller, Andreas H.; Lang, Dieter; Kunze, Jens; Testa, Bernard; Wilson, Ian D.; Glen, Robert C.; Schneider, Gisbert

    2015-04-24

    metabolites. These xenobiotics also include synthetic drugs, in addition to naturally occurring substances (e.g. bacterial, fungal and herbal toxins), often produced as part of a specific defence mechanism. Recent studies have highlighted the often... Metabolic enzymes and effectors involved in their regulation are known for remarkable ligand promiscuity. The plasticity and size of their binding sites (some of them have two or more) is a direct result of their function, which in the case of xenobiotic...

  8. Extreme luminosity imaging conical spectrograph

    SciTech Connect (OSTI)

    Pikuz, S. A.; Shelkovenko, T. A.; Mitchell, M. D.; Chandler, K. M.; Douglass, J. D.; McBride, R. D.; Jackson, D. P.; Hammer, D. A.

    2006-10-15

    A new configuration for a two-dimensional (2D) imaging x-ray spectrograph based on a conically bent crystal is introduced: extreme luminosity imaging conical spectrograph (ELICS). The ELICS configuration has important advantages over spectrographs that are based on cylindrically and spherically bent crystals. The main advantages are that a wide variety of large-aperture crystals can be used, and any desired magnification in the spatial direction (the direction orthogonal to spectral dispersion) can be achieved by the use of different experimental arrangements. The ELICS can be set up so that the detector plane is almost perpendicular to the incident rays, a good configuration for time-resolved spectroscopy. ELICSs with mica crystals of 45x90 mm{sup 2} aperture have been successfully used for imaging on the XP and COBRA pulsed power generators, yielding spectra with spatial resolution in 2D of Z pinches and X pinches.

  9. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, D.N. Jr.; Simpson, M.L.

    1997-10-21

    A miniature lens system that corrects for imaging and chromatic aberrations is disclosed, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components. 2 figs.

  10. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, Jr., David N. (Knoxville, TN); Simpson, Marc L. (Knoxville, TN)

    1997-01-01

    A miniature lens system that corrects for imaging and chromatic aberrations, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components.

  11. Electronic imaging system and technique

    DOE Patents [OSTI]

    Bolstad, J.O.

    1984-06-12

    A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

  12. Electronic imaging system and technique

    DOE Patents [OSTI]

    Bolstad, Jon O. (Idaho Falls, ID)

    1987-01-01

    A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

  13. NEUTRON IMAGING, RADIOGRAPHY AND TOMOGRAPHY.

    SciTech Connect (OSTI)

    SMITH,G.C.

    2002-03-01

    Neutrons are an invaluable probe in a wide range of scientific, medical and commercial endeavors. Many of these applications require the recording of an image of the neutron signal, either in one-dimension or in two-dimensions. We summarize the reactions of neutrons with the most important elements that are used for their detection. A description is then given of the major techniques used in neutron imaging, with emphasis on the detection media and position readout principle. Important characteristics such as position resolution, linearity, counting rate capability and sensitivity to gamma-background are discussed. Finally, the application of a subset of these instruments in radiology and tomography is described.

  14. Multispectral imaging method and apparatus

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Vargo, T.D.; Lockhart, R.R.; Descour, M.R.; Richards-Kortum, R.

    1999-07-06

    A multispectral imaging method and apparatus are described which are adapted for use in determining material properties, especially properties characteristic of abnormal non-dermal cells. A target is illuminated with a narrow band light beam. The target expresses light in response to the excitation. The expressed light is collected and the target's response at specific response wavelengths to specific excitation wavelengths is measured. From the measured multispectral response the target's properties can be determined. A sealed, remote probe and robust components can be used for cervical imaging. 5 figs.

  15. Gamma-ray Imaging Methods

    SciTech Connect (OSTI)

    Vetter, K; Mihailescu, L; Nelson, K; Valentine, J; Wright, D

    2006-10-05

    In this document we discuss specific implementations for gamma-ray imaging instruments including the principle of operation and describe systems which have been built and demonstrated as well as systems currently under development. There are several fundamentally different technologies each with specific operational requirements and performance trade offs. We provide an overview of the different gamma-ray imaging techniques and briefly discuss challenges and limitations associated with each modality (in the appendix we give detailed descriptions of specific implementations for many of these technologies). In Section 3 we summarize the performance and operational aspects in tabular form as an aid for comparing technologies and mapping technologies to potential applications.

  16. X-ray Imaging Workshop

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorkingLos Alamos verifies largest single goldWindX-Ray ImagingInImaging and

  17. Image change detection systems, methods, and articles of manufacture

    DOE Patents [OSTI]

    Jones, James L. (Idaho Falls, ID); Lassahn, Gordon D. (Idaho Falls, ID); Lancaster, Gregory D. (Idaho Falls, ID)

    2010-01-05

    Aspects of the invention relate to image change detection systems, methods, and articles of manufacture. According to one aspect, a method of identifying differences between a plurality of images is described. The method includes loading a source image and a target image into memory of a computer, constructing source and target edge images from the source and target images to enable processing of multiband images, displaying the source and target images on a display device of the computer, aligning the source and target edge images, switching displaying of the source image and the target image on the display device, to enable identification of differences between the source image and the target image.

  18. Multi-channel medical imaging system

    DOE Patents [OSTI]

    Frangioni, John V

    2013-12-31

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  19. Buried object detection in GPR images

    DOE Patents [OSTI]

    Paglieroni, David W; Chambers, David H; Bond, Steven W; Beer, W. Reginald

    2014-04-29

    A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

  20. The ethics of ‘smart drugs’: Moral judgments about healthy people’s use of cognitive-enhancing drugs

    E-Print Network [OSTI]

    Scheske, Christel; Schnall, Simone

    2012-01-01

    daily basis, presumably at least in part to become more cognitively alert, that coffee is the second most commonly traded commodity in the world, surpassed only by crude oil (Trade Commodities, 2011). Thus, mild cognitive enhancement derived from... state that a behavior is wrong in the absence of any supporting evidence. In particular, concerns about the naturalness of CE drugs may follow a moral intuition rather than defensible reasons. A widespread belief is that natural products...

  1. The ethics of ‘smart drugs’: Moral judgments about healthy people’s use of cognitive-enhancing drugs

    E-Print Network [OSTI]

    Scheske, Christel; Schnall, Simone

    2012-01-01

    to become more cognitively alert, that coffee is the second most commonly traded commodity in the world, sur- passed only by crude oil (Trade Commodities, 2011). Thus, mild cognitive enhancement derived from plant sources is very much part of daily life... . In particular, concerns about the naturalness of CE drugs may follow a moral intuition rather than defens- ible reasons. A widespread belief is that natural products are healthier than artificial ones (Britten, 1994; Britten, Ukoumunne, & Boulton, 2002; Giveon...

  2. Upright cone beam CT imaging using the onboard imager

    SciTech Connect (OSTI)

    Fave, Xenia Martin, Rachael; Yang, Jinzhong; Balter, Peter; Court, Laurence; Carvalho, Luis; Pan, Tinsu

    2014-06-15

    Purpose: Many patients could benefit from being treated in an upright position. The objectives of this study were to determine whether cone beam computed tomography (CBCT) could be used to acquire upright images for treatment planning and to demonstrate whether reconstruction of upright images maintained accurate geometry and Hounsfield units (HUs). Methods: A TrueBeam linac was programmed in developer mode to take upright CBCT images. The gantry head was positioned at 0°, and the couch was rotated to 270°. The x-ray source and detector arms were extended to their lateral positions. The x-ray source and gantry remained stationary as fluoroscopic projections were taken and the couch was rotated from 270° to 90°. The x-ray tube current was normalized to deposit the same dose (measured using a calibrated Farmer ion chamber) as that received during a clinical helical CT scan to the center of a cylindrical, polyethylene phantom. To extend the field of view, two couch rotation scans were taken with the detector offset 15 cm superiorly and then 15 cm inferiorly. The images from these two scans were stitched together before reconstruction. Upright reconstructions were compared to reconstructions from simulation CT scans of the same phantoms. Two methods were investigated for correcting the HUs, including direct calibration and mapping the values from a simulation CT. Results: Overall geometry, spatial linearity, and high contrast resolution were maintained in upright reconstructions. Some artifacts were created and HU accuracy was compromised; however, these limitations could be removed by mapping the HUs from a simulation CT to the upright reconstruction for treatment planning. Conclusions: The feasibility of using the TrueBeam linac to take upright CBCT images was demonstrated. This technique is straightforward to implement and could be of enormous benefit to patients with thoracic tumors or those who find a supine position difficult to endure.

  3. Hadamard multimode optical imaging transceiver

    DOE Patents [OSTI]

    Cooke, Bradly J; Guenther, David C; Tiee, Joe J; Kellum, Mervyn J; Olivas, Nicholas L; Weisse-Bernstein, Nina R; Judd, Stephen L; Braun, Thomas R

    2012-10-30

    Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture.

  4. Image Compression by Back Propagation

    E-Print Network [OSTI]

    Cottrell, Garrison W.

    CHAPTER 9 Image Compression by Back Propagation: An Example of Extensional Programming* GARRISON W the case with the computatiolls associated with basic cognitive pro- cesses such as vision and audition techniques. The technique we employ is known as back propagation. developed by l1umelhart, Hinton

  5. Aspherical lens design and imaging

    E-Print Network [OSTI]

    Cristian E. Gutierrez; Ahmad Sabra

    2015-07-29

    We design freeform lenses refracting an arbitrarily given incident field into a given fixed direction. In the near field case, we study the existence of lenses refracting a given bright object into a predefined image. We also analyze the existence of systems of mirrors that solve the near field and the far field problems for reflection.

  6. Thermo Tracer Infrared Thermal Imager

    E-Print Network [OSTI]

    Walker, D. Greg

    -range area G Environment monitoring Volcano, ecology, vegetation, global warming, pollution G R&D Evaluation is a fixed installation type infrared thermal imaging camera to monitor important facilities Production line monitoring Quality anomalies in production processes G Facility monitoring Anomalies

  7. Imaging Science Israel J. Vaughn

    E-Print Network [OSTI]

    Lega, Joceline

    Imaging Science Israel J. Vaughn Advanced Sensing Laboratory College of Optical Sciences University.D. in Optical Sciences Vaughn,Tyo (ASL ­ OSC ­ UA) August 6, 2013 2 / 9 #12;Some personal info B.S. in Math M.S. in Math Ph.D. in Optical Sciences Vaughn,Tyo (ASL ­ OSC ­ UA) August 6, 2013 2 / 9 #12;Some personal info

  8. Medical Image Segmentation Xiaolei Huang

    E-Print Network [OSTI]

    Huang, Xiaolei

    . The National Electrical Manufacturers Association (NEMA) holds the copyright to the DICOM standard. Medical (CAT), Magnetic Resonance Imaging (MRI), Ultrasound, and X-Ray, in standard DICOM formats are often and Communications in Medicine (DICOM) standard is created as a cooperative international standard for communication

  9. UNCORRECTEDPROOF Please cite this article in press as: Chen, H. et al., Nanonization strategies for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009

    E-Print Network [OSTI]

    Gao, Jinming

    2010-01-01

    , Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China Poor water solubility for poorly water-soluble drugs, Drug Discov Today (2010), doi:10.1016/j.drudis.2010.02.009 Drug Discovery Today Volume 00, Number 00 March 2010 REVIEWS Nanonization strategies for poorly water-soluble drugs

  10. Deep Sky Astronomical Image Database Project at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deep Sky Astronomical Image Database Deep Sky Astronomical Image Database Key Challenges: Develop, store, analyze, and make available an astronomical image database of...

  11. Magic of Numbers in Networks of Wireless Image Sensors

    E-Print Network [OSTI]

    Rahimi, Mohammed; Ahmadian, Shaun; Zats, David; Laufer, Rafael; Estrin, D

    2006-01-01

    are solved on the battery- operated image sensor nodes andwith wireless battery-operated image sensors, we havedepicts a network of battery- operated image sensors placed

  12. Search Log Analysis of the ARTstor Cultural Heritage Image Database

    E-Print Network [OSTI]

    Lowe, Heather Ann

    2013-01-01

    Patterns in a Digital Image Database. Information RetrievalCultural Heritage Image Database A thesis submitted inCultural Heritage Image Database by Heather Ann Lowe Master

  13. Automatic Microaneurysm Detection and Characterization Through Digital Color Fundus Images

    E-Print Network [OSTI]

    Martins, Charles

    2010-01-01

    retinal images. International Conference on Image Processing,retinal angiograms of diabetic patients. In International Conference on Image Analysis and Processing (

  14. SIP : a smart digital image processing library

    E-Print Network [OSTI]

    Zhou, Mengyao

    2005-01-01

    The Smart Image Processing (SIP) library was developed to provide automated real-time digital image processing functions on camera phones with integer microprocessors. Many of the functions are not available on commercial ...

  15. Gradient characterization in magnetic resonance imaging

    E-Print Network [OSTI]

    Cheng, Joseph Yitan

    2007-01-01

    Special magnetic resonance (MR) scans, such as spiral imaging and echo-planar imaging, require speed and gradient accuracy while putting high demands on the MR gradient system that may cause gradient distortion. Additionally, ...

  16. Thermal ghost imaging with averaged speckle patterns

    E-Print Network [OSTI]

    Shapiro, Jeffrey H.

    We present theoretical and experimental results showing that a thermal ghost imaging system can produce images of high quality even when it uses detectors so slow that they respond only to intensity-averaged (that is, ...

  17. A Visual Category Filter Google Images , Zisserman

    E-Print Network [OSTI]

    Zisserman, Andrew

    image returned Google's image search a number object categories including bottles, camels, cars, horses a contaminated training a minimal amount supervi­ sion. therefore method Fergus [10], extending it allow

  18. Integrated computational system for portable retinal imaging

    E-Print Network [OSTI]

    Boggess, Jason (Jason Robert)

    2012-01-01

    This thesis introduces a system to improve image quality obtained from a low-light CMOS camera-specifically designed to image the surface of the retina. The retinal tissue, as well as having various diseases of its own, ...

  19. Image sense disambiguation : a multimodal approach

    E-Print Network [OSTI]

    Saenko, Ekaterina, 1976-

    2009-01-01

    If a picture is worth a thousand words, can a thousand words be worth a training image? Most successful object recognition algorithms require manually annotated images of objects to be collected for training. The amount ...

  20. Data visualization of biological microscopy image analyses

    E-Print Network [OSTI]

    Scelfo, Tony (Tony W.)

    2006-01-01

    The Open Microscopy Environment (OME) provides biologists with a framework to store, analyze and manipulate large sets of image data. Current microscopes are capable of generating large numbers of images and when coupled ...

  1. Perceptually inspired image estimation and enhancement

    E-Print Network [OSTI]

    Li, Yuanzhen, Ph. D. Massachusetts Institute of Technology

    2009-01-01

    In this thesis, we present three image estimation and enhancement algorithms inspired by human vision. In the first part of the thesis, we propose an algorithm for mapping one image to another based on the statistics of a ...

  2. Information efficiency in hyperspectral imaging systems

    E-Print Network [OSTI]

    Reichenbach, Stephen E.

    Information efficiency in hyperspectral imaging systems Stephen E. Reichenbach University develop a method for assessing the in- formation density and efficiency of hyperspectral imaging systems width can efficiently gather information about a scene by allocating bandwidth among the bands according

  3. BIOMEDICAL MATHEMATICS: Promising Directions in Imaging,

    E-Print Network [OSTI]

    Censor, Yair

    BIOMEDICAL MATHEMATICS: Promising Directions in Imaging, Therapy Planning, and Inverse Problems #12;BIOMEDICAL MATHEMATICS: Promising Directions in Imaging, Therapy Planning, and Inverse Problems Yair Censor, Ming Jiang, Ge Wang Editors The Huangguoshu International Interdisciplinary Conference on Biomedical

  4. Automatic caption generation for news images 

    E-Print Network [OSTI]

    Feng, Yansong

    2011-06-30

    This thesis is concerned with the task of automatically generating captions for images, which is important for many image-related applications. Automatic description generation for video frames would help security ...

  5. Robust phase sensitive inversion recovery imaging 

    E-Print Network [OSTI]

    Garach, Ravindra Mahendrakumar

    2005-11-01

    Imaging. (August 2005) Garach, Ravindra Mahendrakumar, B.E., Gujarat University Chair of Advisory Committee: Dr. Jim Ji Inversion Recovery (IR) is a powerful tool for contrast manipulation in Mag- netic Resonance Imaging (MRI). IR can provide strong...

  6. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26

    (2014) Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents. PLoS ONE 9(11): e113402. doi:10.1371/journal.pone. 0113402 Editor: Ashley M. Buckle, Monash University, Australia Received: June 10, 2014 Accepted: October 24, 2014 Published... stock solution was prepared by dissolving lyophilised cortisol (Sigma Aldrich) in 80% ethanol to make a 500 mM solution, which was then diluted with water to make solutions of 20, 40 and 80 mM, with water being used as a negative control. Aliquots...

  7. Photogrammetry & Machine Vision 1. Image sensors

    E-Print Network [OSTI]

    Giger, Christine

    Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image'Apuzzo Photogrammetry and Machine Vision - 3 Point cloud processing, surface generation, texturing (b) Camera, noise) 2N. D'Apuzzo Photogrammetry and Machine Vision - 3 Point cloud processing, surface generation

  8. Low Light Image Enhancement via Sparse Representations

    E-Print Network [OSTI]

    Tsakalides, Panagiotis

    Low Light Image Enhancement via Sparse Representations Konstantina Fotiadou , Grigorios,greg,tsakalid}@ics.forth.gr Abstract. Enhancing the quality of low light images is a critical pro- cessing function both from images captured under low illumination conditions based on the mathematical framework of Sparse

  9. Frontiers in Chemical Imaging Seminar Series

    E-Print Network [OSTI]

    Frontiers in Chemical Imaging Seminar Series Advancing Methods for Labeling, Staining, Imaging of Neurosciences University of California, San Diego Abstract A grand goal in neuroscience research will highlight development and application of new contrasting methods and imaging tools that have allowed us

  10. Chemical Imaging Initiative Delivering New Capabilities for

    E-Print Network [OSTI]

    or with light-source capabilities to image materials of importance to the nation's energy and environmentalChemical Imaging Initiative Delivering New Capabilities for In Situ, Molecular-Scale Imaging A complete, precise and realistic view of chemical, materials and biochemical processes and an understanding

  11. Imaging passive seismic data Brad Artman

    E-Print Network [OSTI]

    Imaging passive seismic data Brad Artman brad@sep.stanford.edu Submitted to Geophysics March 2005, CA 94305-2215 ABSTRACT Passive seismic imaging is the process of synthesizing the wealth to produce a subsurface image. For passively acquired data, migration is even more important than for active

  12. Fundamentals of 3D Laplacian Image pyramids

    E-Print Network [OSTI]

    Nielsen, Frank

    is efficient for sampling as it removes high-frequency components. (sample at fewer positions.) Gaussian kernel: Application to blending Multiband blending. Blending two overlapping images using their pyramids Compute) with the rightmost half of L (I2). Reconstruct blended images from the Laplacian pyramid L r. #12;Laplacian image

  13. McCausland Center For Brain Imaging

    E-Print Network [OSTI]

    Almor, Amit

    .mricro.com). he Siemens 3-Tesla Magnetic Resonance Imag- ing system at the McCausland Center for Brain Imaging the Palmetto Richland Memorial Hospi- tal. The Siemens 3-Tesla magnetic resonance imag- ing system is fitted brain remains one of the great scientific challenges of our generation. With approximately 100 billion

  14. Image Analysis Model-Based Methods

    E-Print Network [OSTI]

    Wolfe, Patrick J.

    Model-Based Methods Comparing and Evaluating Models Summary Further Reading Data Collection ScientificImage Analysis Model-Based Methods Comparing and Evaluating Models Summary Further Reading Fully Low-Count Image Analysis #12;Image Analysis Model-Based Methods Comparing and Evaluating Models

  15. Institute for Functional Imaging of Materials

    E-Print Network [OSTI]

    Weston, Ken

    Institute for Functional Imaging of Materials (IFIM) Guiding the design of materials tailored Kalman filters New methods Bigdata Imaging Electronic Structure Molecular Dynamics Multiscale Ab Initio dynamics electrons to materials and architectures #12;3 Imaging: The big picture ORNL has unique strengths

  16. Fast neutron imaging device and method

    DOE Patents [OSTI]

    Popov, Vladimir; Degtiarenko, Pavel; Musatov, Igor V.

    2014-02-11

    A fast neutron imaging apparatus and method of constructing fast neutron radiography images, the apparatus including a neutron source and a detector that provides event-by-event acquisition of position and energy deposition, and optionally timing and pulse shape for each individual neutron event detected by the detector. The method for constructing fast neutron radiography images utilizes the apparatus of the invention.

  17. Locating Secret Messages in Images Ian Davidson

    E-Print Network [OSTI]

    Davidson, Ian

    Locating Secret Messages in Images Ian Davidson Computer Science, SUNY Albany 1400 Washington in innocuous media such as images, while steganalysis is the field of detecting these secret messages contributing the most to the energy calculations of an image are deemed outliers. Typically, of the top third

  18. Automatic Detection and Classification of Sunspot Images

    E-Print Network [OSTI]

    Wolfe, Patrick J.

    Automatic Detection and Classification of Sunspot Images Thomas C. M. Lee tlee with Alex Young and the SaFeDe Solar Imaging Group JSM 2007 ­ p. 1/2 #12;Outline Title: Automatic Detection and Classification of Sunspot Images JSM 2007 ­ p. 2/2 #12;Outline Title: Automatic Detection and Classification

  19. POSTDOCTORAL POSITION Biomedical Image Computing Group

    E-Print Network [OSTI]

    Salvaggio, Carl

    POSTDOCTORAL POSITION Biomedical Image Computing Group University of Washington, Seattle, WA. Departments of Pediatrics, Bioengineering and Radiology www.depts.washington.edu/bicg The Biomedical Image to acquire, process and analyze biomedical imaging data of the developing brain. The postdoctoral researcher

  20. Photographing paintings by image fusion Gloria Haro

    E-Print Network [OSTI]

    Photographing paintings by image fusion Gloria Haro Dept. of Information and Communications a quality photograph of a painting by multi-image fusion methods. The problem is particularly challenging in most photographs of paintings. A fully automatic image processing chain is described that, starting

  1. Errors in Quantitative Image Analysis due to

    E-Print Network [OSTI]

    Rubin, Daniel L.

    ; Massachusetts General Hospital, Boston, MA Abstract PURPOSE: To evaluate the ability of various software (SW different SW tools to measure compartment-specific region-of-interest intensity. RESULTS: Images generated for by the majority of tested quantitative image analysis SW tools. Incorrect image scaling leads to intensity

  2. Image-Guided Fracture David Mould

    E-Print Network [OSTI]

    Mould, David

    Image-Guided Fracture David Mould Department of Computer Science University of Saskatchewan Abstract We present an image filter that transforms an input line drawing into an image of a fractured of an uncracked texture. Key words: Non-photorealistic rendering, fracture, tex- ture synthesis 1 Introduction Non

  3. Digital image library development in academic environment

    E-Print Network [OSTI]

    Corran, Ruth

    1 Digital image library development in academic environment: designing and testing usability@aup.fr Keywords: Digital image library, usability, student projects, participatory design Abstract Case study Purpose By reporting the experience gained in the development of a digital image library in academic

  4. NATURAL IMAGE UTILITY ASSESSMENT USING IMAGE CONTOURS David M. Rouse and Sheila S. Hemami

    E-Print Network [OSTI]

    Hemami, Sheila S.

    NATURAL IMAGE UTILITY ASSESSMENT USING IMAGE CONTOURS David M. Rouse and Sheila S. Hemami Visual to a reference. For the utility assessment task, observers evaluate the usefulness of a natural image cannot generally predict the perceived utility of a natural image. This paper examines variations

  5. Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy

    E-Print Network [OSTI]

    Boas, David

    Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution States Available online 11 September 2004 Near-infrared spectroscopy (NIRS) and diffuse optical imaging currently being made and issues to consider for improving optical image quality. These include the optimal

  6. Bayesian fusion of multi-band image fusion Bayesian fusion of multi-band image fusion

    E-Print Network [OSTI]

    Tourneret, Jean-Yves

    Bayesian fusion of multi-band image fusion Bayesian fusion of multi-band image fusion Beyond for Latent Variables", Feb. 2-4 2015 1 / 64 #12;Bayesian fusion of multi-band image fusion Context Multi School "Search for Latent Variables", Feb. 2-4 2015 2 / 64 #12;Bayesian fusion of multi-band image fusion

  7. Supplemental Material for "Efficient MR Image Reconstruction for Compressed MR Imaging"

    E-Print Network [OSTI]

    Huang, Junzhou

    D MR images: cardiac, brain, chest and artery respectively. Figure 1, 2, 3 and 4 shows the visual complexity. (a) (b) (c) (d) (e) (f) Fig. 1. Cardiac MR image reconstruction from 20% sampling (a) OriginalSupplemental Material for "Efficient MR Image Reconstruction for Compressed MR Imaging" Paper ID

  8. Abstract Title: Image Informatics Tools for the Analysis of Retinal Images

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    Barbara, Santa Barbara, CA. Keywords: 682 retinal detachment, 541 image processing, 543 imagingAbstract Title: Image Informatics Tools for the Analysis of Retinal Images Presentation Start/End Time: Wednesday, May 03, 2006, 11:15 AM - 1:00 PM Location: Hall B/C Reviewing Code: 289 retinal

  9. Dynamic imaging with electron microscopy

    ScienceCinema (OSTI)

    Campbell, Geoffrey; McKeown, Joe; Santala, Melissa

    2014-05-30

    Livermore researchers have perfected an electron microscope to study fast-evolving material processes and chemical reactions. By applying engineering, microscopy, and laser expertise to the decades-old technology of electron microscopy, the dynamic transmission electron microscope (DTEM) team has developed a technique that can capture images of phenomena that are both very small and very fast. DTEM uses a precisely timed laser pulse to achieve a short but intense electron beam for imaging. When synchronized with a dynamic event in the microscope's field of view, DTEM allows scientists to record and measure material changes in action. A new movie-mode capability, which earned a 2013 R&D 100 Award from R&D Magazine, uses up to nine laser pulses to sequentially capture fast, irreversible, even one-of-a-kind material changes at the nanometer scale. DTEM projects are advancing basic and applied materials research, including such areas as nanostructure growth, phase transformations, and chemical reactions.

  10. Image compression/decompression based on mathematical transform, reduction/expansion, and image sharpening

    DOE Patents [OSTI]

    Fu, C.Y.; Petrich, L.I.

    1997-12-30

    An image represented in a first image array of pixels is first decimated in two dimensions before being compressed by a predefined compression algorithm such as JPEG. Another possible predefined compression algorithm can involve a wavelet technique. The compressed, reduced image is then transmitted over the limited bandwidth transmission medium, and the transmitted image is decompressed using an algorithm which is an inverse of the predefined compression algorithm (such as reverse JPEG). The decompressed, reduced image is then interpolated back to its original array size. Edges (contours) in the image are then sharpened to enhance the perceptual quality of the reconstructed image. Specific sharpening techniques are described. 22 figs.

  11. Radiation-tolerant imaging device

    DOE Patents [OSTI]

    Colella, N.J.; Kimbrough, J.R.

    1996-11-19

    A barrier at a uniform depth for an entire wafer is used to produce imaging devices less susceptible to noise pulses produced by the passage of ionizing radiation. The barrier prevents charge created in the bulk silicon of a CCD detector or a semiconductor logic or memory device from entering the collection volume of each pixel in the imaging device. The charge barrier is a physical barrier, a potential barrier, or a combination of both. The physical barrier is formed by an SiO{sub 2} insulator. The potential barrier is formed by increasing the concentration of majority carriers (holes) to combine with the electron`s generated by the ionizing radiation. A manufacturer of CCD imaging devices can produce radiation-tolerant devices by merely changing the wafer type fed into his process stream from a standard wafer to one possessing a barrier beneath its surface, thus introducing a very small added cost to his production cost. An effective barrier type is an SiO{sub 2} layer. 7 figs.

  12. Radiation-tolerant imaging device

    DOE Patents [OSTI]

    Colella, Nicholas J. (Livermore, CA); Kimbrough, Joseph R. (Pleasanton, CA)

    1996-01-01

    A barrier at a uniform depth for an entire wafer is used to produce imaging devices less susceptible to noise pulses produced by the passage of ionizing radiation. The barrier prevents charge created in the bulk silicon of a CCD detector or a semiconductor logic or memory device from entering the collection volume of each pixel in the imaging device. The charge barrier is a physical barrier, a potential barrier, or a combination of both. The physical barrier is formed by an SiO.sub.2 insulator. The potential barrier is formed by increasing the concentration of majority carriers (holes) to combine with the electron's generated by the ionizing radiation. A manufacturer of CCD imaging devices can produce radiation-tolerant devices by merely changing the wafer type fed into his process stream from a standard wafer to one possessing a barrier beneath its surface, thus introducing a very small added cost to his production cost. An effective barrier type is an SiO.sub.2 layer.

  13. Collaborative Initiative in Biomedical Imaging to Study Complex Diseases

    SciTech Connect (OSTI)

    Lin, Weili; Fiddy, Michael A.

    2012-03-31

    The work reported addressed these topics: Fluorescence imaging; Optical coherence tomography; X-ray interferometer/phase imaging system; Quantitative imaging from scattered fields, Terahertz imaging and spectroscopy; and Multiphoton and Raman microscopy.

  14. Image display device in digital TV

    DOE Patents [OSTI]

    Choi, Seung Jong (Seoul, KR)

    2006-07-18

    Disclosed is an image display device in a digital TV that is capable of carrying out the conversion into various kinds of resolution by using single bit map data in the digital TV. The image display device includes: a data processing part for executing bit map conversion, compression, restoration and format-conversion for text data; a memory for storing the bit map data obtained according to the bit map conversion and compression in the data processing part and image data inputted from an arbitrary receiving part, the receiving part receiving one of digital image data and analog image data; an image outputting part for reading the image data from the memory; and a display processing part for mixing the image data read from the image outputting part and the bit map data converted in format from the a data processing part. Therefore, the image display device according to the present invention can convert text data in such a manner as to correspond with various resolution, carry out the compression for bit map data, thereby reducing the memory space, and support text data of an HTML format, thereby providing the image with the text data of various shapes.

  15. Image Registration for Stability Testing of MEMS

    E-Print Network [OSTI]

    Memarsadeghi, Nargess; Blake, Peter N; Morey, Peter A; Landsman, Wayne B; Chambers, Victor J; Moseley, Samuel H; 10.1117/12.872076

    2013-01-01

    Image registration, or alignment of two or more images covering the same scenes or objects, is of great interest in many disciplines such as remote sensing, medical imaging, astronomy, and computer vision. In this paper, we introduce a new application of image registration algorithms. We demonstrate how through a wavelet based image registration algorithm, engineers can evaluate stability of Micro-Electro-Mechanical Systems (MEMS). In particular, we applied image registration algorithms to assess alignment stability of the MicroShutters Subsystem (MSS) of the Near Infrared Spectrograph (NIRSpec) instrument of the James Webb Space Telescope (JWST). This work introduces a new methodology for evaluating stability of MEMS devices to engineers as well as a new application of image registration algorithms to computer scientists.

  16. Heartbeat of a Nest: Using Imagers as Biological Sensors

    E-Print Network [OSTI]

    2007-01-01

    servers send periodic battery reading, image con- ?gurationcon?guration, image acquisition and reading of the battery

  17. L.J. van Vliet, F.R. Boddeke, D. Sudar, and I.T. Young, Image Detectors for Digital Image Microscopy, in: M.H.F. Wilkinson, F. Schut (eds.), Digital Image Analysis of Microbes; Imaging, Morphometry,

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    Microscopy, in: M.H.F. Wilkinson, F. Schut (eds.), Digital Image Analysis of Microbes; Imaging, Morphometry

  18. Image

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    RTINEZ Governor JOHN A. SANCHEZ Lieutenant Governor NEW MEXICO ENVIRONMENT DEPARTMENT Hazardous Waste Bureau 2905 Rodeo Park Drive East, Building 1 Santa Fe, New Mexico 87505-6303...

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    LLC P.O. Box 2078 Carlsbad, New Mexico 88221-5608 RE: CLASS 1 MODIFICATION, AUGUST 29, 2013 WIPP HAZARDOUS WASTE FACILITY PERMIT EPA I.D. NUMBER NM4890139088 Dear Messrs....

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    Work 11 * 04300 - Unit Masonry System. 12 1.3 Reference Documents 13 "Reference Stratigraphy and Rock Properties for the Waste Isolation Pilot Plant (WIPP) Project" 14 by R.D....

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    Governor July 29, 2013 Jose Franco, Manager Carlsbad Field Office Department of Energy P.O. Box 3090 NEW MEXICO ENVIRONMENT DEPARTMENT Hazardous Waste Bureau 2905 Rodeo...

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministration Medal01 Sandia4) AugustA. -71- Particulate: Columns 59 and RLos Alamos

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    National Nuclear Security Administration (NNSA)

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