Sample records for imaging antifungal drug

  1. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImagerImaging Antifungal

  2. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm)Hydrogen StorageITERITERBuilding EnergyImaging PrintImaging

  3. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm)Hydrogen StorageITERITERBuilding EnergyImagingImaging

  4. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImager Spots andImaging

  5. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImager SpotsImaging

  6. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm)Hydrogen StorageITERITERBuilding EnergyImaging

  7. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImager Spots and

  8. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImager Spots

  9. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |Hot SpringsemployedImager

  10. Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,*

    E-Print Network [OSTI]

    Bulyk, Martha L.

    Suppressive Drug Interactions between Antifungals Marjon G.J. de Vos1 and Tobias Bollenbach1,* 1IST a systematic study of drug interactions be- tween antifungal compounds. Suppressive drug interactions occur. When two drugs are combined, they may interact synergistically or antago- nistically; for synergistic

  11. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Gilliam, Jacob T. (Norwalk, IA); Hunter-Cevera, Jennie (Elliott City, MD); Presnail, James K. (Avondale, PA); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2009-09-15T23:59:59.000Z

    The invention relates to antifungal compositions and methods for protecting a plant from a fungal pathogen. Compositions including antifungal polypeptides isolated from a fungal fermentation broth are provided.

  12. Imaging in Drug Discovery and Development

    E-Print Network [OSTI]

    Zanibbi, Richard

    Imaging in Drug Discovery and Development Raymond Gibson Senior Investigator Merck, Sharp and Dohme aaarrrccchhhiiivvveeesss aaannnddd aaabbbssstttrrraaaccctttsss... #12;Abstract With the desire to develop novel drugs faster and more cost-effectively, drug companies are searching for clear strategies to manage the complex

  13. Advances in Lymphatic Imaging and Drug Delivery

    SciTech Connect (OSTI)

    Nune, Satish K.; Gunda, Padmaja; Majeti, Bharat K.; Thallapally, Praveen K.; Laird, Forrest M.

    2011-09-10T23:59:59.000Z

    Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.

  14. Imaging Antifungal Drug Molecules in Action using Soft X-Ray...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are...

  15. Biological in situ Dose Painting for Image-Guided Radiation Therapy Using Drug-Loaded Implantable Devices

    SciTech Connect (OSTI)

    Cormack, Robert A. [Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (United States); Sridhar, Srinivas [Electronics Materials Research Institute, Northeastern University, and Department of Physics, Northeastern University, Boston, Massachusetts (United States); Suh, W. Warren; D'Amico, Anthony V. [Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (United States); Makrigiorgos, G. Mike, E-mail: mmakrigiorgos@lroc.harvard.ed [Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (United States)

    2010-02-01T23:59:59.000Z

    Purpose: Implantable devices routinely used for increasing spatial accuracy in modern image-guided radiation treatments (IGRT), such as fiducials or brachytherapy spacers, encompass the potential for in situ release of biologically active drugs, providing an opportunity to enhance the therapeutic ratio. We model this new approach for two types of treatment. Methods and Materials: Radiopaque fiducials used in IGRT, or prostate brachytherapy spacers ('eluters'), were assumed to be loaded with radiosensitizer for in situ drug slow release. An analytic function describing the concentration of radiosensitizer versus distance from eluters, depending on diffusion-elimination properties of the drug in tissue, was developed. Tumor coverage by the drug was modeled for tumors typical of lung stereotactic body radiation therapy treatments for various eluter dimensions and drug properties. Six prostate {sup 125}I brachytherapy cases were analyzed by assuming implantation of drug-loaded spacers. Radiosensitizer-induced subvolume boost was simulated from which biologically effective doses for typical radiosensitizers were calculated in one example. Results: Drug distributions from three-dimensional arrangements of drug eluters versus eluter size and drug properties were tabulated. Four radiosensitizer-loaded fiducials provide adequate radiosensitization for {approx}4-cm-diameter lung tumors, thus potentially boosting biologically equivalent doses in centrally located stereotactic body treated lesions. Similarly, multiple drug-loaded spacers provide prostate brachytherapy with flexible shaping of 'biologically equivalent doses' to fit requirements difficult to meet by using radiation alone, e.g., boosting a high-risk region juxtaposed to the urethra while respecting normal tissue tolerance of both the urethra and the rectum. Conclusions: Drug loading of implantable devices routinely used in IGRT provides new opportunities for therapy modulation via biological in situ dose painting.

  16. Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drugdrug interaction induced by liver metabolites

    SciTech Connect (OSTI)

    Nakanishi, Takeo; Ikenaga, Miho; Fukuda, Hajime; Matsunaga, Norikazu; Tamai, Ikumi, E-mail: tamai@p.kanazawa-w.ac.jp

    2012-09-01T23:59:59.000Z

    We previously reported a quantitative time-lapse imaging (QTLI)-based analysis method to assess drugdrug interactions (DDI) at multidrug resistance-associated protein 2 (Mrp2) in rat sandwich-cultured hepatocyte (SCH) system, utilizing the fluorescent Mrp2 substrate, 5-(and 6)-carboxy-2?,7?-dichlorofluorescein (CDF). Here, we aimed to examine the feasibility of using QTLI to evaluate DDI involving drug metabolite(s) generated in hepatocytes. We used estradiol (E2) and bilirubin as model compounds; both are not substrates of MRP2, whereas their hepatic metabolites, estradiol-17?-glucuronide (E17G) or bilirubin glucuronides, are known to be its substrates as well as inhibitors. When rat SCHs were pre-exposed with E2, fluorescence of CDF accumulated in bile canaliculi decreased depending upon both the duration of pre-exposure and the concentration of extracellular E2. The decrease corresponded with the increase in intracellular concentration of E17G in hepatocytes. Furthermore, cytotoxicity of vinblastine, a substrate of MRP2, was enhanced in SCHs treated with E2. Similarly, CDF accumulated in bile canaliculi was significantly reduced in rat SCHs pre-exposed with bilirubin. In conclusion, these results suggest that phase II biotransformation of a competitor is reflected in alteration of MRP2-mediated CDF transport detected in QTLI. The QTLI might provide a convenient platform to evaluate transporter-based DDIs involving hepatic metabolites of drug candidates without the need to identify the metabolites. -- Highlights: ? Mrp2-mediated CDF transport is inhibited by E2, but not E17G in vesicle study. ? Both E2 and E17G do not compromise CDF formation from CDFDA in hepatocytes. ? CDF accumulation in bile canaliculi is inhibited by E2 or E17G in QTLI. ? Increasing exposure to E2 decreases CDF accumulation in bile canaliculi in QTLI. ? QTLI is feasible to assess Mrp2-based DDI involving drug metabolite in hepatocytes.

  17. Evotec has teamed up with the Harwell Imaging Partnership (HIP) to maximise the potential of their research into cancer treatment drugs

    E-Print Network [OSTI]

    Zharkova, Valentina V.

    of their research into cancer treatment drugs using the Science and Technology Facilities Council (STFC)'s Central-based cancer treatments work by inhibiting the signals that cause mutated cancer cells to divide and multiply to the treatment. The ability to conduct single-cell imaging of inhibitor drugs binding their target in cancer

  18. antifungal susceptibility test: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    antifungal susceptibility test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Antifungal Testing and...

  19. drug discovery drug discovery

    E-Print Network [OSTI]

    drug discovery at Purdue #12;drug discovery 2 #12;drug discovery 3 Introduction The drug discovery and innovative drug candidates to treat chronic and acute illnesses. Our researchers also continue to be invested in various approaches to drug discovery, which include understanding of drug targets for future drug

  20. Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism

    SciTech Connect (OSTI)

    Blatherwick, Eleanor Q. [University of Warwick, UK; Van Berkel, Gary J [ORNL; Pickup, Kathryn [AstraZeneca R& D Sweden; Johansson, Maria K. [AstraZeneca R& D Sweden; Beaudoin, Marie-Eve [AstraZeneca, USA; Cole, Roderic [ORNL; Day, Jennifer M. [AstraZeneca R& D, UK; Iverson, Suzanne [AstraZeneca R& D Sweden; Wilson, Ian D. [AstraZeneca R& D, UK; Scrivens, James H. [University of Warwick, UK; Weston, Daniel J. [AstraZeneca R& D, UK

    2011-01-01T23:59:59.000Z

    1. Tissue distribution studies of drug molecules play an essential role in the pharmaceutical industry and are commonly undertaken using quantitative whole body autoradiography (QWBA) methods. 2. The growing need for complementary methods to address some scientific gaps around radiography methods has led to increased use of mass spectrometric imaging (MSI) technology over the last 5 to 10 years. More recently, the development of novel mass spectrometric techniques for ambient surface sampling has redefined what can be regarded as fit-for-purpose for MSI in a drug metabolism and disposition arena. 3. Together with a review of these novel alternatives, this paper details the use of two liquid microjunction (LMJ)- based mass spectrometric surface sampling technologies. These approaches are used to provide qualitative determination of parent drug in rat liver tissue slices using liquid extraction surface analysis (LESA) and to assess the performance of a LMJ surface sampling probe (LMJ-SSP) interface for quantitative assessment of parent drug in brain, liver and muscle tissue slices. 4. An assessment of the utility of these spatially-resolved sampling methods is given, showing interdependence between mass spectrometric and QWBA methods, in particular there emerges a reason to question typical MSI workflows for drug metabolism; suggesting the expedient use of profile or region analysis may be more appropriate, rather than generating time-intensive molecular images of the entire tissue section.

  1. Atmospheric pressure cold plasma as an antifungal therapy

    SciTech Connect (OSTI)

    Sun Peng; Wu Haiyan [College of Engineering, Peking University, Beijing 100871 (China); Sun Yi; Liu Wei; Li Ruoyu [Department of Dermatology and Venereology, Peking Univ. 1st Hospital and Research Center for Medical Mycology, Peking Univ., Beijing 100034 (China); Zhu Weidong; Lopez, Jose L. [Department of Applied Science and Technology and Center for Microplasma Science and Technology, Saint Peter's College, Jersey City, New Jersey 07306 (United States); Zhang Jue; Fang Jing [College of Engineering, Peking University, Beijing 100871 (China); Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China)

    2011-01-10T23:59:59.000Z

    A microhollow cathode based, direct-current, atmospheric pressure, He/O{sub 2} (2%) cold plasma microjet was used to inactive antifungal resistants Candida albicans, Candida krusei, and Candida glabrata in air and in water. Effective inactivation (>90%) was achieved in 10 min in air and 1 min in water. Antifungal susceptibility tests showed drastic reduction of the minimum inhibitory concentration after plasma treatment. The inactivation was attributed to the reactive oxygen species generated in plasma or in water. Hydroxyl and singlet molecular oxygen radicals were detected in plasma-water system by electron spin resonance spectroscopy. This approach proposed a promising clinical dermatology therapy.

  2. In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv Kumar*, Apurva Kulkarni, Dattatri K Nagesha, Srinivas Sridhar

    E-Print Network [OSTI]

    Sridhar, Srinivas

    and controlled drug delivery. CdSe quantum dots (QDs) and anti-cancer drug, doxorubicin (Dox), were co absorbance and fluorescence features of QDs and Dox. TEM and DLS studies yielded a size of

  3. E-Print Network 3.0 - anti-fungal drug design Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: Allergy & sinus medicines and products Feminine anti-fungalanti-itch...

  4. Comparison of Fusion Imaging Using a Combined SPECT/CT System and Intra-arterial CT: Assessment of Drug Distribution by an Implantable Port System in Patients Undergoing Hepatic Arterial Infusion Chemotherapy

    SciTech Connect (OSTI)

    Ikeda, Osamu, E-mail: osamu-3643ik@do9.enjoy.ne.jp; Kusunoki, Shinichiroh; Nakaura, Takeshi; Shiraishi, Shinya; Kawanaka, Kouichi; Tomiguchi, Seiji; Yamashita, Yasuyuki [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, Hiroshi; Chikamoto, Akira; Kanemitsu, Keiichiro [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Gastroenterological Surgery (Japan)

    2006-06-15T23:59:59.000Z

    Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinoma of the liver. We compared the perfusion patterns of HAI chemotherapy on intra-arterial port-catheter computed tomography (iapc-CT) and fused images obtained with a combined single-photon emission computed tomography/computed tomography (SPECT/CT) system. We studied 28 patients with primary or metastatic carcinoma of the liver who bore an implantable HAI port system. All underwent abdominal SPECT using Tc-99m-MAA (185 Mbq); the injection rate was 1 mL/min, identical to the chemotherapy infusion rate, and 0.5 mL/sec for iapc-CT. Delivery was through an implantable port. We compared the intrahepatic perfusion (IHP) and extrahepatic perfusion (EHP) patterns of HAI chemotherapy on iapc-CT images and fused images obtained with a combined SPECT/CT system. In 23 of 28 patients (82%), IHP patterns on iapc-CT images and fused images were identical. In 5 of the 28 patients (18%), IHP on fusion images was different from IHP on iapc-CT images. EHP was seen on fused images in 12 of the 28 patients (43%) and on iapc-CT images in 8 patients (29%). In 17 patients (61%), upper gastrointestinal endoscopy revealed gastroduodenal mucosal lesions. EHP was revealed on fused images in 10 of these patients; 9 of them manifested gastroduodenal toxicity at the time of subsequent HAI chemotherapy. Fusion imaging using the combined SPECT/CT system reflects the actual distribution of the infused anticancer agent. This information is valuable not only for monitoring adequate drug distribution but also for avoiding potential extrahepatic complications.

  5. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNotSeventyTechnologiesfacilityImaging

  6. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm)Hydrogen StorageITERITERBuilding EnergyImaging Print The

  7. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm)Hydrogen StorageITERITERBuilding EnergyImaging Print

  8. Similarity Between Obesity and Drug Addiction as Assessed

    E-Print Network [OSTI]

    Homes, Christopher C.

    Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging: A Concept. Overeating in obese individuals shares similarities with the loss of control and compulsive drug taking]: "Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging: A Concept Review." Wang

  9. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01T23:59:59.000Z

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  10. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    Drug Delivery DOI: 10.1002/anie.200802260 Sustained Release of Drugs Dispersed in Polymer) was observed for up to 40 days with up to 90% drug recovery. In vivo bioluminescence imaging of transgenic mice, represents a new drug delivery approach with great potential, particularly if particles can be targeted

  11. SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG

    E-Print Network [OSTI]

    Tipple, Brett

    SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG DELIVERY SYSTEMS Register on-line: www on Recent Advances in Drug Delivery Systems "Drug Delivery: the penetrating challenges" Pioneering event in the field New drug targeting methods Improved delivery strategies Imaging and treatment combinations

  12. antifungal immune response: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vivo imaging of immune cell dynamics in skin in response to zinc-oxide nanoparticle exposure Boppart, Stephen 138 Transcriptomic Analysis of Host Immune and Cell Death...

  13. Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle

    E-Print Network [OSTI]

    Zhang, Liangfang

    Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery Santosh Aryal, Che-Ming Jack Hu, and Liangfang Zhang* A new approach to loading multiple drugs onto the same drug through hydrolyzable linkers to form drug conjugates, is reported. In contrast to loading individual types

  14. Evaluation of Extrahepatic Perfusion of Anticancer Drugs in the Right Gastric Arterial Region on Fused Images Using Combined CT/SPECT: Is Extrahepatic Perfusion Predictive of Gastric Toxicity?

    SciTech Connect (OSTI)

    Ikeda, Osamu, E-mail: osamu-3643ik@do9.enjoy.ne.jp; Tamura, Yoshitaka; Nakasone, Yutaka; Shiraishi, Shinya; Kawanaka, Kouichi; Tomiguchi, Seiji; Morishita, Shouji [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, Hiroshi; Chikamoto, Akira; Kanemitsu, Keiichirou [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Gastroenterological Surgery (Japan); Yamashita, Yasuyuki [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan)

    2007-06-15T23:59:59.000Z

    Background. Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinomas of the liver. Since hepatic arteries also supply the stomach and duodenum, HAI may result in unwanted infusion into the upper gastrointestinal tract and consequent gastric toxicity. Using fused images obtained with a combined SPECT/CT system, we assessed extrahepatic perfusion (EHP) and its correlation with gastrointestinal toxicity in patients receiving HAI. Methods. We studied 41 patients with primary or metastatic carcinoma of the liver who received HAI chemotherapy consisting of 5-fluorouracil and cisplatin. All underwent abdominal SPECT using a {sup 99m}Tc-MAA (185 MBq) instrument and an injection rate of 0.1 ml/min, identical to the chemotherapy infusion rate. Delivery was through an implantable port. We analyzed the distribution of the anticancer agent on fused images and the relationship between EHP of the right gastric arterial region and gastric toxicity. All patients underwent esophagogastroduodenoscopy (EGDS). Results. Of the 41 patients, 11 (27%) manifested enhancement of the duodenal and gastric pyloric region on fused images. EGDS at the time of reservoir placement detected gastric ulcers in 10 of these patients. Conclusion. Fusion imaging with combined SPECT/CT reflects the actual distribution of the infused anticancer agents. The detection of EHP on fused images is predictive of the direct gastric toxicity from anticancer agents in patients undergoing HAI.

  15. Drug Overdose Deaths, Hospitalizations,

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 #12; Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 20002012

  16. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  17. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  18. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  19. Tissue Imaging Using Nanospray Desorption Electrospray Ionization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drug discovery, molecular biology, and biochemistry. Citation: Laskin J, BS Heath, PJ Roach, LH Cazares, and OJ Semmes.2012."Tissue Imaging Using Nanospray Desorption...

  20. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Granger, IA); Crane, Virginia C. (Des Moines, IA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Gilliam, Jacob T. (Norwalk, IA); Hunter-Cevera, Jennie (Elliott City, MD); Presnail, James K. (Avondale, PA); Schepers, Eric J. (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2009-10-06T23:59:59.000Z

    The invention relates to compositions including amino acid sequences isolated from fungal fermentation broths and methods for protecting a plant from a pathogen, particularly a fungal pathogen.

  1. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Ellanskaya, legal representative, Natalia (Kyiv, IL); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (Clive, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA); Ellanskaya, deceased, Irina (Kyiv, IL)

    2007-12-11T23:59:59.000Z

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  2. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Elleskaya, Irina (Kyiv, UA); Ellanskaya, legal representative; Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2010-08-10T23:59:59.000Z

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  3. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Waukee, IA); Dahlbacka, Glen (Oakland, CA); Elleskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, IA); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2011-04-12T23:59:59.000Z

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  4. Antifungal polypeptides

    DOE Patents [OSTI]

    Altier, Daniel J. (Granger, IA); Dahlbacka, Glen (Oakland, CA); Ellanskaya, Irina (Kyiv, UA); Ellanskaya, legal representative, Natalia (Kyiv, UA); Herrmann, Rafael (Wilmington, DE); Hunter-Cevera, Jennie (Elliott City, MD); McCutchen, Billy F. (College Station, TX); Presnail, James K. (Avondale, PA); Rice, Janet A. (Wilmington, DE); Schepers, Eric (Port Deposit, MD); Simmons, Carl R. (Des Moines, IA); Torok, Tamas (Richmond, CA); Yalpani, Nasser (Johnston, IA)

    2012-04-03T23:59:59.000Z

    Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include novel amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from microbial fermentation broths. Nucleic acid molecules comprising nucleotide sequences that encode the antipathogenic polypeptides of the invention are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention, or variant or fragment thereof, are also disclosed.

  5. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  6. Chemoinformatics in drug development

    E-Print Network [OSTI]

    2012-05-01T23:59:59.000Z

    ORAL PRESENTATION Open Access Chemoinformatics in drug development Colin R Groom From 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany. 6-8 November 2011 It would be unimaginable to prosecute a drug discovery program... to the contributions that can be made as a candidate molecule progresses towards becoming part of a drug substance. This presentation will highlight the opportunities for the application of chemoinformatics techniques to the area of pharmaceutical materials science, a...

  7. Nanoparticle drug delivery enhances the cytotoxicity of hydrophobichydrophilic drug conjugates

    E-Print Network [OSTI]

    Zhang, Liangfang

    Nanoparticle drug delivery enhances the cytotoxicity of hydrophobichydrophilic drug conjugates, Accepted 4th October 2011 DOI: 10.1039/c1jm13834k We report a drug conjugation approach to concurrently load both hydrophobic and hydrophilic drugs into the same drug delivery nanocarrier in a precisely

  8. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug, in the case of small molecules such as Dox, enzymes would not interfere with the drug and hence the elution

  9. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01T23:59:59.000Z

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  10. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01T23:59:59.000Z

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  11. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  12. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01T23:59:59.000Z

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilmans The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  13. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  14. Chemical signatures and new drug targets for gametocytocidal drug

    E-Print Network [OSTI]

    Arnold, Jonathan

    Chemical signatures and new drug targets for gametocytocidal drug development Wei Sun1 *, Takeshi Q antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria screening 5,215 known drugs and compounds. All these compounds were active against three strains

  15. Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry

    SciTech Connect (OSTI)

    Sagaram, Uma S.; El-Mounadi, Kaoutar; Buchko, Garry W.; Berg, Howard R.; Kaur, Jagdeep; Pandurangi, Raghoottama; Smith, Thomas J.; Shah, Dilip

    2013-12-04T23:59:59.000Z

    A highly conserved plant defensin MtDef4 potently inhibits the growth of a filamentous fungus Fusarium graminearum. MtDef4 is internalized by cells of F. graminearum. To determine its mechanism of fungal cell entry and antifungal action, NMR solution structure of MtDef4 has been determined. The analysis of its structure has revealed a positively charged patch on the surface of the protein consisting of arginine residues in its ?-core signature, a major determinant of the antifungal activity of MtDef4. Here, we report functional analysis of the RGFRRR motif of the ?-core signature of MtDef4. The replacement of RGFRRR to AAAARR or to RGFRAA not only abolishes fungal cell entry but also results in loss of the antifungal activity of MtDef4. MtDef4 binds strongly to phosphatidic acid (PA), a precursor for the biosynthesis of membrane phospholipids and a signaling lipid known to recruit cytosolic proteins to membranes. Mutations of RGFRRR which abolish fungal cell entry of MtDef4 also impair its binding to PA. Our results suggest that RGFRRR motif is a translocation signal for entry of MtDef4 into fungal cells and that this positively charged motif likely mediates interaction of this defensin with PA as part of its antifungal action.

  16. Essays on Drug Use and Crime

    E-Print Network [OSTI]

    Deza, Monica

    2012-01-01T23:59:59.000Z

    Prinz. A. , 1997, Do European drugs policies mater? Economicruin? Sequences of initiation to drugs and crime in Britain.and P. Grimes, 2001, Adolescent Drug Use and Educational

  17. Developing novel polymer architectures for applications In magnetic resonance imaging and self-assembly

    E-Print Network [OSTI]

    McCombs, Jessica R. (Jessica Rose)

    2013-01-01T23:59:59.000Z

    Macromolecular scaffolds for drug delivery, self-assembly, and imaging applications have attracted significant attention over the last several decades. As polymerization techniques become more sophisticated, it becomes ...

  18. Copper(II) complexes with 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid: Syntheses, crystal structures and antifungal activities

    SciTech Connect (OSTI)

    Xiong, Pingping [Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069 (China); Li, Jie [Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Shaanxi Provincial Key Laboratory of Biotechnology, Xi'an 710069 (China); Bu, Huaiyu, E-mail: 7213792@qq.com [Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Shaanxi Provincial Key Laboratory of Biotechnology, Xi'an 710069 (China); Wei, Qing [Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069 (China); Zhang, Ruolin [Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), Shaanxi Provincial Key Laboratory of Biotechnology, Xi'an 710069 (China); Chen, Sanping, E-mail: sanpingchen@126.com [Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069 (China)

    2014-07-01T23:59:59.000Z

    Reaction of Cu(II) with an asymmetric semi-rigid organic ligand 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid (HL), yielded five compounds, [Cu{sub 0.5}L]{sub n} (1), [Cu(HL){sub 2}Cl{sub 2}]{sub n} (2), [Cu(HL){sub 2}Cl{sub 2}(H{sub 2}O)] (3), [Cu(L){sub 2}(H{sub 2}O)]{sub n} (4) and [Cu(L)(phen)(HCO{sub 2})]{sub n} (5), which have been fully characterized by infrared spectroscopy, elemental analysis, and single-crystal X-ray diffraction. As for compounds 1, 2 and 5, Cu(II) is bridged through HL, Cl{sup -}, and formic acid, respectively, featuring 1D chain-structure. In compound 3, Cu(II) with hexahedral coordination sphere is assembled through hydrogen-bonding into 3D supramolecular framework. In compound 4, 1D chain units CuOCuO are ligand-bridged into a 3D network. All compounds were tested on fungi (Fusarium graminearum, Altemaria solani, Macrophoma kawatsukai, Alternaria alternata and Colletotrichum gloeosporioides). Compound 1 exhibits a better antifungal effect compared to other compounds. An effect of structure on the antifungal activity has also been correlated. - Graphical abstract: Copper(II) compounds with 4-(1H-1, 2, 4-trizol-1-ylmethyl) benzoic acid, were prepared, structurally characterized and investigated for antifungal activity. - Highlights: The title compounds formed by thermodynamics and thermokinetics. The five compounds show higher inhibition percentage than reactants. The structure effect on the antifungal activity.

  19. informedRx Preferred Drug List -Effective July 1, 2012 Preferred Drug List

    E-Print Network [OSTI]

    Scharer, John E.

    informedRx Preferred Drug List - Effective July 1, 2012 Preferred Drug List Brand name drugs are listed in CAPITAL letters and generic drugs are listed in lowercase italics. Generic drugs are preferred, if available. If generic drugs are available and not listed on the formulary, but the brand name drug is

  20. Test Images

    E-Print Network [OSTI]

    Test Images. I hope to have a set of test images for the course soon. Some images are available now; some will have to wait until I can find another 100-200

  1. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01T23:59:59.000Z

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  2. Image Analysis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Recognition Image Analysis and Recognition Snapshot1498121slicesqResedison Fibers permeating imaged material (Courtesy: Bale, Loring, Perciano and Ushizima) Imagery coming from...

  3. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  4. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  5. Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia

    E-Print Network [OSTI]

    Purdon, Patrick Lee

    It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging ...

  6. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  7. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  8. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  9. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  10. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  11. Computer-Aided Drug Target Search

    E-Print Network [OSTI]

    Chen, Yuzong

    Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

  12. Rethinking Americas Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    2006. The Market for Illegal Goods: The Case of Drugs. Informing Americas Policy on Illegal Drugs: What We DontViewpoints. Should Illegal Drugs Be Decriminalized? In

  13. People Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    People Images People Images Several hundred of the 1700 U.S. scientists contributing to the LHC accelerator and experiments gathered in June 2008 in CERN's building 40 CE0252 Joel...

  14. Image alignment

    DOE Patents [OSTI]

    Dowell, Larry Jonathan

    2014-04-22T23:59:59.000Z

    Disclosed is a method and device for aligning at least two digital images. An embodiment may use frequency-domain transforms of small tiles created from each image to identify substantially similar, "distinguishing" features within each of the images, and then align the images together based on the location of the distinguishing features. To accomplish this, an embodiment may create equal sized tile sub-images for each image. A "key" for each tile may be created by performing a frequency-domain transform calculation on each tile. A information-distance difference between each possible pair of tiles on each image may be calculated to identify distinguishing features. From analysis of the information-distance differences of the pairs of tiles, a subset of tiles with high discrimination metrics in relation to other tiles may be located for each image. The subset of distinguishing tiles for each image may then be compared to locate tiles with substantially similar keys and/or information-distance metrics to other tiles of other images. Once similar tiles are located for each image, the images may be aligned in relation to the identified similar tiles.

  15. DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE:_____________________________

    E-Print Network [OSTI]

    Acton, Scott

    DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE and/or efficacy of a drug? A. If yes, is the testing, study, evaluation or research primarily for use in pharmaceutical pre-market clearance applications to the Food and Drug Administration? 2. Is drug administered

  16. SPIE Medical Imaging Medical Imaging

    E-Print Network [OSTI]

    Miga, Michael I.

    CT and SPECT (GE Hawkeye) SPIE Medical Imaging 2006 28 CT/PET System Combined CT and PET (Siemens Medical Imaging 2006 10 Computed Tomography (CT) 3D Tomography from multiple projections #12;6 SPIE: Scintillation Camera SPIE Medical Imaging 2006 26 PET and SPECT PET = Positron Emission Tomography SPECT

  17. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    containers, pickup hazardous drug waste and provide chemo spill kits to appropriate areas. The OfficeHAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS, administration and disposal of drug residues. Drugs are classified as hazardous if studies in animals and

  18. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Getoor, Lise

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  19. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  20. ForPeerReview Drug user dynamics: a compartmental model of drug users

    E-Print Network [OSTI]

    Triolo, Livio

    ForPeerReview Only Drug user dynamics: a compartmental model of drug users for scenario analyses Journal: Drugs: Education, Prevention & Policy Manuscript ID: CDEP-2012-0094.R1 Manuscript Type: Original papers Keywords: Drug use, Epidemics, Compartmental modeling, Scenario analysis, Evaluation, Drug policy

  1. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  2. Advances in lasers, optics, and imaging for the life sciences

    E-Print Network [OSTI]

    Heller, Eric

    Molecular Imaging Congress BioOpto Japan BioOpticsWorld.com "Invisible" molecules glow with new label- free possibilities for biomedical imaging, such as label- free mapping drug distributions and blood vessels on and off at 5 MHz. The spectrally filtered stimulation beam is detected by a large area photodiode

  3. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  4. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01T23:59:59.000Z

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  5. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is the probability that the tested individual uses this illegal drug? What is the probability of a false positive

  6. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01T23:59:59.000Z

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  7. adverse drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  8. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  9. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

  10. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01T23:59:59.000Z

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  11. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed megafund financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  12. Drug delivery Preparation of Monodisperse Biodegradable Polymer

    E-Print Network [OSTI]

    Prentiss, Mara

    Drug delivery Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-Focusing Device for Controlled Drug Delivery Qiaobing Xu, Michinao Hashimoto, Tram T. Dang, Todd microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved

  13. prescription drug program highlights retail pharmacy prescriptions

    E-Print Network [OSTI]

    Scharer, John E.

    prescription drug program highlights SHIP retail pharmacy prescriptions The informedRx retail interactions and duplicate therapies. Brand name and generic drugs are included in your pharmacy benefit, but you will save the most money by selecting generic drug options when available. On myinformedRx.com you

  14. CMVO Drug Testing Program Request for Information

    E-Print Network [OSTI]

    Mazzotti, Frank

    CMVO Drug Testing Program Request for Information TO: RE: Name (First, M.I., Last) Social Security substances testing records. Please complete this form and return it to: University of Florida CMVO Drug or she has tested positive, or refused to test, on any pre-employment drug or alcohol test administered

  15. Investigational Drug/Device Accountability Policy Introduction

    E-Print Network [OSTI]

    Subramanian, Venkat

    2/11/08 Investigational Drug/Device Accountability Policy Introduction: Good clinical research investigational drug or device used in a research trial at Washington University. This is true whether the study-initiated trial using department funds. Our institutional responsibility requires that any investigational drug

  16. A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND

    E-Print Network [OSTI]

    Wang, Yuqing

    A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND ALCOHOL In conformance with the existing law or be under the influence of illegal drugs and/or alcohol as prohibited by state and federal law at University enforcement agencies responsible for enforcing laws related to the use of illegal drugs and alcohol. Students

  17. Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Atorvastatin. Major side

  18. Drug Saf . Author manuscript Discourse on safe drug use: symbolic logics and ethical aspects

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Drug Saf . Author manuscript Page /1 5 Discourse on safe drug use: symbolic logics and ethical.fainzang@orange.fr > Abstract Drug safety is not a matter for healthcare professionals alone. As actors, patients are also concerned, at three different levels: 1) with regard to their behaviour and choices of drugs, with a view

  19. 1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds

    E-Print Network [OSTI]

    Marchiori, Elena

    1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds using a weighted@cs.ru.nl,elenam@cs.ru.nl Abstract In silico discovery of interactions between drug compounds and target proteins is of core importance for improving the efficiency of the laborious and costly experimental determination of drug

  20. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  1. Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Simvastatin. Major side

  2. Detect adverse drug reactions for drug Alendronate Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Alendronate Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Alendronate. Major side

  3. 2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free

    E-Print Network [OSTI]

    Tullos, Desiree

    2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free Schools & Campuses from drugs and alcohol. The University supports programs for the prevention of abuse of alcohol. Biennial Review Process Oregon State University has a long history of engaging in drug and alcohol

  4. Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Pioglitazone. Major side

  5. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws realting

  6. Rethinking Americas Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

  7. Emerging pathogens: Dynamics, mutation and drug resistance

    SciTech Connect (OSTI)

    Perelson, A.S.; Goldstein, B.; Korber, B.T. [and others

    1997-10-01T23:59:59.000Z

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objectives of this project were to develop models of the spread of pathogens, such as HIV-1 and influenza, in humans, and then to use the models to address the possibility of designing appropriate drug therapies that may limit the ability of the pathogen to escape treatment by mutating into a drug resistant form. We have developed a model of drug-resistance to amantidine and rimantadine, the two major antiviral drugs used to treat influenza, and have used the model to suggest treatment strategies during an epidemic.

  8. Analysis of Assembly Bill 310: Prescription Drugs

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    survey found that fourth-tier drug copayments averaged $85 in 2009 (KFF, Differential cost sharing is one utilization management technique plans

  9. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  10. Hyperspectral Imaging or Imaging Spectroscopy

    E-Print Network [OSTI]

    Gilbes, Fernando

    (nm) Cosmic Rays Gamma Rays X Rays Microwaves (Radar) Radio & Television WavesUV 105 106 107 108 109 the image cube by scanning through it. The conventional methods are whiskbroom (a), filter/Fourier transform Optics Scene FOVx X-Dimension Scanning Mechanism Focusing Optics #12;Whiskbroom Sensor Accumulation

  11. New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes

    E-Print Network [OSTI]

    Feigon, Brooke

    New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes double of Type II Diabetes. Prescriptions for the drugs, known as thiazolidinediones, have doubled over the last. The results are published in the August edition of the journal Diabetes Care. Congregation 2007 page 59 Race

  12. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, Glen A. (Los Alamos, NM)

    1999-01-01T23:59:59.000Z

    Radiation-hard, steady-state imaging bolometer. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas.

  13. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, G.A.

    1999-01-19T23:59:59.000Z

    Radiation-hard, steady-state imaging bolometer is disclosed. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas. 2 figs.

  14. POLICY STATEMENT ON DRUG-FREE CAMPUS*

    E-Print Network [OSTI]

    Karsai, Istvan

    11 POLICY STATEMENT ON DRUG-FREE CAMPUS* It is the policy of ETSU that the unlawful manufacture, distribution, possession, use of alcohol and illicit drugs on the ETSU campus, in the workplace (on or off campus), on property owned or controlled by ETSU, or as part of any activity of ETSU is strictly

  15. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  16. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab brand name Yervoyat $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  17. Prescription Drug List --To be used by members

    E-Print Network [OSTI]

    Mullins, Dyche

    Prescription Program Drug List -- To be used by members (both National Accounts and Local Group), who have a tiered drug plan. Anthem Blue Cross prescription drug benefits include medications available on the Anthem Drug List. Our prescription drug benefits can offer potential savings when your

  18. anti-tuberculosis drug ethionamide: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  19. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  20. Chest Swelling and Fever in an Intravenous Drug User

    E-Print Network [OSTI]

    Grijalva, Ray A.; Ritter, Michael; Langdorf, Mark I.

    2008-01-01T23:59:59.000Z

    aeruginosa serotype 011 from drug addicts. J Infect Dis,JA, Pierre JD. Injection drug use in North America. Infectand Fever in an Intravenous Drug User Ray A. Grijalva Jr. ,

  1. RESEARCH Open Access Impact of physical incompatibility on drug mass

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    RESEARCH Open Access Impact of physical incompatibility on drug mass flow rates: example drugs simultaneously but through limited venous accesses. Several intravenous therapies have rates of drugs infused simultaneously to the patient, through an in vitro study. Methods: Furosemide

  2. Drug Discovery and Development from Marine Biology-Based Research

    E-Print Network [OSTI]

    Jawitz, James W.

    Drug Discovery and Development from Marine Biology- Based Research Oceanyx Pharmaceuticals is a novel drug discovery and development company that leverages marine biology-based natural identified two lead candidates, largazole and apratoxin, as potential drug candidates for the treatment

  3. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug manufacturing, drug delivery, and medical diagnostics. By learning how substances behave differently's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  4. Prescription Drug Monitoring Programs: Examining Limitations and Future Approaches

    E-Print Network [OSTI]

    Griggs, Christopher A.; Weiner, Scott G.; Feldman, James A.

    2015-01-01T23:59:59.000Z

    Li G, Brady JE, Lang B, et al. Prescription drug monitoringand drug overdose mortality. Inj Epidemiol. 2014;1:1-9.EM, Desai HA. Prescription drug monitoring programs and

  5. FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX

    E-Print Network [OSTI]

    MacLean, Jenifer Anne

    2010-12-16T23:59:59.000Z

    ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of ...

  6. WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

  7. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  8. Lensless imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9 5 -ofLearningLensless4 Lensless Imaging of

  9. Proper Usage of Drugs and Chemicals in Food Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2002-02-15T23:59:59.000Z

    Federal regulations exist to ensure the proper distribution and usage of veterinary drugs and to prevent adulteration of the food supply with illegal drug residues through drug misuse in food produc- ing animals. The Food and Drug Administration... of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals...

  10. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  11. E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  12. Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment

    E-Print Network [OSTI]

    2007-04-20T23:59:59.000Z

    Smith and Wahl (2005) used an impulsive differential equation to model drug ... In Smith (2006), the dynamics of drug are modeled by impulsive differential...

  13. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  14. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study...

  15. antiepileptic drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  16. Food and drug reward: overlapping circuits in human obesity and addiction

    SciTech Connect (OSTI)

    Volkow N. D.; Wang G.; Volkow, N.D.; Wang, G.-J.; Fowler, J.S.; Tomasi, D.; Baler, R.

    2012-12-01T23:59:59.000Z

    Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense of others. This model is consistent with the fact that both drugs and food have powerful reinforcing effects - partly mediated by dopamine increases in the limbic system - that, under certain circumstances or in vulnerable individuals, could overwhelm the brain's homeostatic control mechanisms. Such parallels have generated significant interest in understanding the shared vulnerabilities and trajectories between addiction and obesity. Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and related behavioral deficits in human subjects. These results suggest that both obese and drug addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning (memory/learning), impulse control (behavioral inhibition), stress reactivity and interoceptive awareness. Here, we integrate findings predominantly derived from positron emission tomography that investigate the role of dopamine in drug addiction and in obesity and propose an updated working model to help identify treatment strategies that may benefit both of these conditions.

  17. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    how drug policy reformers used the ballot initiative processand future directions for reformers. Bocks (2000) work isto analyze how drug policy reformers frame their actions and

  18. Intradermal needle-free powdered drug injection

    E-Print Network [OSTI]

    Liu, John (John Hsiao-Yung)

    2012-01-01T23:59:59.000Z

    This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

  19. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  20. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  1. NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM

    E-Print Network [OSTI]

    Hart, Steven N.

    2011-02-22T23:59:59.000Z

    Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

  2. Femtosecond Transient Imaging

    E-Print Network [OSTI]

    Kirmani, Ahmed (Ghulam Ahmed)

    2010-01-01T23:59:59.000Z

    This thesis proposes a novel framework called transient imaging for image formation and scene understanding through impulse illumination and time images. Using time-of-flight cameras and multi-path analysis of global light ...

  3. biocompatibility, stability, , p-p multi-drug

    E-Print Network [OSTI]

    Hong, Deog Ki

    , biocompatibility, stability, , p-p .2 multi-drug resistance gene co- delivered photothermal , , . , biocompatibility, stability, , p-p .2 multi-drug resistance gene co graphene oxide-para amino benzoic acid nanosheet as effective drug delivery system to treat drug resistant

  4. B. Comp Dissertation SNP Data Integration and Analysis for Drug-

    E-Print Network [OSTI]

    Wong, Limsoon

    B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response Biomarker Discovery 2008/2009 #12;i B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response methods to develop drugs targeted at various diseases. To maximize drug viability and profit, one

  5. Illegal Drugs Policy Swansea University and Students' Union

    E-Print Network [OSTI]

    Martin, Ralph R.

    Illegal Drugs Policy Swansea University and Students' Union #12;Illegal Drugs Policy for Swansea 2. Who is covered by the policy? 3. Aims of the policy 5. What do we mean by illegal drugs? 4 illegal drug use. Take very seriously our legal duty of care to our students, staff and visitors and aim

  6. Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing

    E-Print Network [OSTI]

    Gates, Kent. S.

    CHEM 4170 Drug Research Assignment This assignment asks you choose a drug and learn how it works. This is NOT a writing assignment, this is a literature research project. The data for your drug will be presented below. Do not choose a drug that has been discussed in detail in Silverman's Book or in class. You may

  7. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  8. Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal

    E-Print Network [OSTI]

    Rosso, Paolo

    Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal Frequent-level and character-level have been proven to have a high discrim- inative power for detecting DDI, while pattern% precision and 84% recall. In [3] the authors propose a first approximation for DDI detection based

  9. Imaging Sciences Workshop Proceedings

    SciTech Connect (OSTI)

    Candy, J.V.

    1996-11-21T23:59:59.000Z

    This report contains the proceedings of the Imaging Sciences Workshop sponsored by C.A.S.LS., the Center for Advanced Signal & Image Sciences. The Center, established primarily to provide a forum where researchers can freely exchange ideas on the signal and image sciences in a comfortable intellectual environment, has grown over the last two years with the opening of a Reference Library (located in Building 272). The Technical Program for the 1996 Workshop include a variety of efforts in the Imaging Sciences including applications in the Microwave Imaging, highlighted by the Micro-Impulse Radar (MIR) system invented at LLNL, as well as other applications in this area. Special sessions organized by various individuals in Speech, Acoustic Ocean Imaging, Radar Ocean Imaging, Ultrasonic Imaging, and Optical Imaging discuss various applica- tions of real world problems. For the more theoretical, sessions on Imaging Algorithms and Computed Tomography were organized as well as for the more pragmatic featuring a session on Imaging Systems.

  10. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03T23:59:59.000Z

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drugs efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

  11. Seismic Imaging and Monitoring

    SciTech Connect (OSTI)

    Huang, Lianjie [Los Alamos National Laboratory

    2012-07-09T23:59:59.000Z

    I give an overview of LANL's capability in seismic imaging and monitoring. I present some seismic imaging and monitoring results, including imaging of complex structures, subsalt imaging of Gulf of Mexico, fault/fracture zone imaging for geothermal exploration at the Jemez pueblo, time-lapse imaging of a walkway vertical seismic profiling data for monitoring CO{sub 2} inject at SACROC, and microseismic event locations for monitoring CO{sub 2} injection at Aneth. These examples demonstrate LANL's high-resolution and high-fidelity seismic imaging and monitoring capabilities.

  12. Federal Student Aid Penalties for Drug Convictions Students convicted of a federal or state offense or possessing illegal drugs that occurred while they were

    E-Print Network [OSTI]

    Sadeh, Norman M.

    offense or possessing illegal drugs that occurred while they were receiving federal student aid should convictions for conspiring to sell drugs.) Possession of Sale of illegal Illegal drugs drugs 1st offense 1

  13. Aerosolized Delivery of Antifungal Agents

    E-Print Network [OSTI]

    Le, Jennifer; Schiller, Daryl S.

    2010-01-01T23:59:59.000Z

    toxicities, such as cough, which is a common adverse effecttension, can greatly influence the occurrence of cough.Induction of cough can occur when the osmolality is less

  14. This Is Your Data on Drugs: Lessons Computer Security Can Learn From The Drug War

    E-Print Network [OSTI]

    Sadeh, Norman M.

    policy surrounding computer security. 1. INTRODUCTION The last three years have seen a growing amount in using observed market prices to draw conclu- sions about illicit drugs, such as marijuana, cocaine

  15. Attitudes toward the integration of smoking cessation treatment into drug abuse clinics.

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Direct Care Workforce in the National Drug Abuse Treatmentdependence treatment into drug abuse care reduces thesecare settings but not yet in independent drug abuse treatment

  16. A Juarez drug lord saved my life. Confessions of an accidental narco

    E-Print Network [OSTI]

    Cruz Rosas, Monica

    2013-01-01T23:59:59.000Z

    Cruz Rosas A Juarez drug lord saved my life Confessions ofarrest someone involved in drug trafficking, they make sureviolent years of the Mexican drug war. Five armed soldiers

  17. Research paper Drug diffusion and binding in ionizable interpenetrating networks

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

  18. Optimization of preclinical profiling operations in drug discovery

    E-Print Network [OSTI]

    Heiney, John P. (John Patrick)

    2007-01-01T23:59:59.000Z

    In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...

  19. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  20. Use of Preventative and Therapeutic Drugs in Show Market Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2001-03-12T23:59:59.000Z

    Various medicines are used in show market livestock and poultry, but exhibitors must ensure that the carcasses do not contain illegal residues of drugs, chemicals and feed additives. Only approved substances should be used. Illegal uses of drugs...

  1. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM),...

  2. Luminal flow amplifies stent-based drug deposition in arterial

    E-Print Network [OSTI]

    Levine, Evan G.

    Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

  3. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01T23:59:59.000Z

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  4. Alignment strategies for drug product process development and manufacturing

    E-Print Network [OSTI]

    Garvin, Christopher John

    2012-01-01T23:59:59.000Z

    The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

  5. Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Laskin, Julia; Heath, Brandi S.; Roach, Patrick J.; Cazares, Lisa H.; Semmes, O. John

    2012-01-03T23:59:59.000Z

    We present the first results showing the ambient imaging of biological samples in their native environment using nanospray desorption ionization (nanoDESI) mass spectrometry. NanoDESI is an ambient pressure ionization technique that enables precise control of ionization of molecules from substrates. We demonstrate highly sensitive and robust analysis of tissue samples with high spatial resolution (<12 {mu}m) without sample preparation, which will be essential for applications in clinical diagnostics, drug discovery, molecular biology, and biochemistry.

  6. Model-Based Dependability Analysis of Programmable Drug Infusion Pumps

    E-Print Network [OSTI]

    Sankaranarayanan, Sriram

    Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

  7. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-07-29T23:59:59.000Z

    The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

  8. Meeting the FDA's Initiative for Protecting the US Drug Supply

    E-Print Network [OSTI]

    Brock, David

    Meeting the FDA's Initiative for Protecting the US Drug Supply Tatsuya Inaba Research Affiliate rapidly. Demographic changes, along with a host of new drugs, are causing greater volumes of raw materials. To achieve these goals for the public good, the Food and Drug Administration (FDA) and individual States

  9. 1. Introduction 2. Apicoplast as a drug target

    E-Print Network [OSTI]

    McFadden, Geoff

    1. Introduction 2. Apicoplast as a drug target 3. Conclusion 4. Expert opinion Review Targeting an excellent drug target. Areas covered: This review focuses on the biological role of the apicoplast in the erythrocytic life cycle and what that reveals about existing drug targets. We also discuss the future

  10. DIVISION OF DRUG ABUSE CONTROL A Project Evaluation

    E-Print Network [OSTI]

    Touretzky, David S.

    L,: . -'" -- . : NARCONON 1/1 DIVISION OF DRUG ABUSE CONTROL FA-48-72 74-007 75-009 A Project. In Relation to the Stated Objectives of the Division of Drug Abuse Control's Application .......... II ........... Appendix C - NARCONON - Division of Drug Abuse Control Contract .................... Appendix D - Job

  11. Samples of Drug Testing Language Memorandum for Human Resources File

    E-Print Network [OSTI]

    Almor, Amit

    Samples of Drug Testing Language Memorandum for Human Resources File DATE: TO: Employee FROM: Supervisor RE: Drug Testing As you know, the position that you have been selected for requires that you pass a pre-employment drug and alcohol test. In addition to the pre-employment test, you will also be subject

  12. NARCSim An Agent-Based Illegal Drug Market Daniela Romano

    E-Print Network [OSTI]

    Romano, Daniela

    NARCSim An Agent-Based Illegal Drug Market Simulation Daniela Romano Computer Science University.Richmond@sheffield.ac.uk Abstract-- Combined forces interventions in the UK's illegal drug market can be designed and evaluated using a serious game, where the illegal drug market can be simulated using an Agent- Based Model

  13. User Science Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Image: OBrianImageBig.png | png | 5 MB SlavaFull.png FES: Small Scale Experimental Plasma Research October 21, 2010 | Author(s): Vyacheslav Lukin (NRL) | Category: Fusion Energy |...

  14. Imaging in radiotherapy

    SciTech Connect (OSTI)

    Taylor, J.

    1987-01-01T23:59:59.000Z

    The text contains details of recording media, image quality, sensitometry, processing and equipment used in radiotherapy for imaging. It reflects part of the syllabus for the College of Radiographers.

  15. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  16. Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses

    E-Print Network [OSTI]

    Wood, Michelle

    2011-12-31T23:59:59.000Z

    This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research used quantitative...

  17. Consumers' Image of Broilers.

    E-Print Network [OSTI]

    Courtenay, Henry V.; Branson, Robert E.

    1962-01-01T23:59:59.000Z

    which they feel the product possesses. This research was designed to determine consumers' favorable and unfavorable images as to broilers, both in making purchases in stores and in serving them as a meat dish. These images, summarized briefly here... count. The Preparation and Cooking Image: The h0u.l wife's image of broilers focuses on one metliotl- frying. The major deterrent to preparing othci dishes was that these are either too difficult or canno* be prepared satisfactorily...

  18. Imaging with Scattered Neutrons

    E-Print Network [OSTI]

    H. Ballhausen; H. Abele; R. Gaehler; M. Trapp; A. Van Overberghe

    2006-10-30T23:59:59.000Z

    We describe a novel experimental technique for neutron imaging with scattered neutrons. These scattered neutrons are of interest for condensed matter physics, because they permit to reveal the local distribution of incoherent and coherent scattering within a sample. In contrast to standard attenuation based imaging, scattered neutron imaging distinguishes between the scattering cross section and the total attenuation cross section including absorption. First successful low-noise millimeter-resolution images by scattered neutron radiography and tomography are presented.

  19. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    reputation-2009-2). Carter, Jimmy. 1977. Drug Abuse Messagea presidential candidate in 1976, Jimmy Carter even adopted

  20. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  1. Near-electrode imager

    DOE Patents [OSTI]

    Rathke, Jerome W. (Lockport, IL); Klingler, Robert J. (Westmont, IL); Woelk, Klaus (Wachtberg, DE); Gerald, II, Rex E. (Brookfield, IL)

    2000-01-01T23:59:59.000Z

    An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager uses the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

  2. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 19902009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

  3. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 19902009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: to identify the key landmarks and influences on the human functional brain imaging

  4. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V

    2013-06-25T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

  5. Magnetic Imaging Wolfgang Kuch

    E-Print Network [OSTI]

    Kuch, Wolfgang

    Magnetic Imaging Wolfgang Kuch Freie Universit¨at Berlin, Institut f¨ur Experimentalphysik, Arnimallee 14, 14195 Berlin, Germany kuch@physik.fu-berlin.de Abstract. Imaging of magnetic domains has- ern techniques is used nowadays routinely for magnetic imaging of magnetic ma- terials

  6. Automation in image cytometry : continuous HCS and kinetic image cytometry

    E-Print Network [OSTI]

    Charlot, David J.

    2012-01-01T23:59:59.000Z

    OF CALIFORNIA, SAN DIEGO Automation in Image Cytometry:xiv Abstract of Dissertation Automation in Image Cytometry:

  7. Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration

    E-Print Network [OSTI]

    Gelman, Andrew

    received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

  8. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Thomas, Mathew; Carson, James P.; Smith, Jordan N.; Timchalk, Charles; Laskin, Julia

    2013-01-15T23:59:59.000Z

    Imaging mass spectrometry offers simultaneous detection of drugs, drug metabolites and endogenous substances in a single experiment. This is important when evaluating effects of a drug on a complex organ system such as the brain, where there is a need to understand how regional drug distribution impacts function. Nicotine is an addictive drug and its action in the brain is of high interest. Here we use nanospray desorption electrospray ionization, nano-DESI, imaging to discover the localization of nicotine in rat brain tissue after in vivo administration of nicotine. Nano-DESI is a new ambient technique that enables spatially-resolved analysis of tissue samples without special sample pretreatment. We demonstrate high sensitivity of nano-DESI imaging that enables detection of only 0.7 fmole nicotine per pixel in the complex brain matrix. Furthermore, by adding deuterated nicotine to the solvent, we examined how matrix effects, ion suppression, and normalization affect the observed nicotine distribution. Finally, we provide preliminary results suggesting that nicotine localizes to the hippocampal substructure called dentate gyrus.

  9. Complete information below if not found on receipt #2 National Drug Code

    E-Print Network [OSTI]

    Aalberts, Daniel P.

    Complete information below if not found on receipt #2 National Drug Code Drug Name___________________________Drug Supply 5. National Drug Code (NDC) 6. Name of drug and strength 7. DAW code (if applicable) 8. Amount paid Tape Prescription Receipt #1 Here No Staples DRUG CLAIM FORM 1. Please type or print clearly

  10. Video Toroid Cavity Imager

    DOE Patents [OSTI]

    Gerald, Rex E. II; Sanchez, Jairo; Rathke, Jerome W.

    2004-08-10T23:59:59.000Z

    A video toroid cavity imager for in situ measurement of electrochemical properties of an electrolytic material sample includes a cylindrical toroid cavity resonator containing the sample and employs NMR and video imaging for providing high-resolution spectral and visual information of molecular characteristics of the sample on a real-time basis. A large magnetic field is applied to the sample under controlled temperature and pressure conditions to simultaneously provide NMR spectroscopy and video imaging capabilities for investigating electrochemical transformations of materials or the evolution of long-range molecular aggregation during cooling of hydrocarbon melts. The video toroid cavity imager includes a miniature commercial video camera with an adjustable lens, a modified compression coin cell imager with a fiat circular principal detector element, and a sample mounted on a transparent circular glass disk, and provides NMR information as well as a video image of a sample, such as a polymer film, with micrometer resolution.

  11. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. [University of Alberta, Department of Surgery (Canada)], E-mail: rmoore@cha.ab.ca; Xiao, Zhengwen [University of Alberta, Cross Cancer Institute, Department of Oncology (Canada); Owen, Richard J.; Ashforth, Robert [University of Alberta, Department of Radiology and Diagnostic Imaging (Canada); Dickey, Dwayne [University of Alberta, Department of Electric Engineering (Canada); Helps, Cathy [Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada); Tulip, John [University of Alberta, Department of Electric Engineering (Canada)

    2008-01-15T23:59:59.000Z

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  12. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, D.N.; Kiel, J.L.; Batishko, C.R.; Stahl, K.A.

    1990-08-14T23:59:59.000Z

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopic imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber. 22 figs.

  13. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, David N. (San Antonio, TX); Kiel, Johnathan L. (San Antonio, TX); Batishko, Charles R. (West Richland, WA); Stahl, Kurt A. (Richland, WA)

    1990-01-01T23:59:59.000Z

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.

  14. BNL | ICS Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    due to the phase-contrast effect. This method will be useful for quantitative computed tomography applications of Thomson sources. High-resolution radiographic image of a wasp...

  15. Ferroelectric optical image comparator

    DOE Patents [OSTI]

    Butler, M.A.; Land, C.E.; Martin, S.J.; Pfeifer, K.B.

    1993-11-30T23:59:59.000Z

    A ferroelectric optical image comparator has a lead lanthanum zirconate titanate thin-film device which is constructed with a semi-transparent or transparent conductive first electrode on one side of the thin film, a conductive metal second electrode on the other side of the thin film, and the second electrode is in contact with a nonconducting substrate. A photoinduced current in the device represents the dot product between a stored image and an image projected onto the first electrode. One-dimensional autocorrelations are performed by measuring this current while displacing the projected image. 7 figures.

  16. Sociodemographic and drug use characteristics, sex behaviors, and motivations for drug use among HIV- seronegative, heterosexual, methamphetamine users in San Diego, CA

    E-Print Network [OSTI]

    Cheng, Wei-Woon Susan

    2009-01-01T23:59:59.000Z

    TL A Comparison of Injection Drug Users (IDU) vs. Non-IDU inDISSERTATIO Sociodemographic and Drug Use Characteristics,and Motivations for Drug Use among HIV-Seronegative,

  17. Drug addiction is a common problem in this country, especially for adolescents. The detrimental effects of exposure to addictive drugs during adolescence continue to

    E-Print Network [OSTI]

    Minnesota, University of

    Background Drug addiction is a common problem in this country, especially for adolescents. The detrimental effects of exposure to addictive drugs during adolescence continue to affect individuals throughout their lifetimes (Yucel, Lubman, Solowlj & Brewer, 2007). Understanding the nature of drug

  18. Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem

    E-Print Network [OSTI]

    Wu, Mingshen

    Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem of alcoholism and drug

  19. Title: Drug and Alcohol Policies --Drug-Free Workplace Code: 1-300-020

    E-Print Network [OSTI]

    Huang, Jianyu

    -free workplace, and, in the case of grantees who are individuals, by requiring each individual to certify to receiving a contract or grant from a federal agency. All grantees who fail to meet the drug-free workplace of the Act. Grantees are not required to make a certification in order to continue receiving funds under

  20. Restoring functional PET Images using Anatomical MR Images

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Restoring functional PET Images using Anatomical MR Images Peter Philipsen, Ulrik Kjems, Peter Toft signal to noise ratio and the low spa­ tial resolution in Positron Emission Tomography (PET) images ? And Positron Emission Tomography (PET) Images? ffl Segmentation of MR Images ­ Extraction of important edges

  1. Compression of Computer Graphics Images with Image-Based Rendering

    E-Print Network [OSTI]

    Shahabi, Cyrus

    Compression of Computer Graphics Images with Image-Based Rendering Ilmi Yoon and Ulrich Neumann information from previously rendered images. Images predicted from prior images are combined with a residual-based rendering tech- nique provides accurate motion prediction and accelerates rendering at the same time

  2. Drugs offshore: companies stepping up fight against hidden adversary

    SciTech Connect (OSTI)

    Redden, J.

    1986-01-01T23:59:59.000Z

    Oil companies worldwide are effectively fighting a growing nemesis, drug and alcohol abuse on offshore installations. It is estimated that companies are losing millions of dollars in lost productivity, accidents, and thefts caused by on-the-job use of illegal drugs. Some of the measures being employed to combat the use of such drugs, e.g., tight control, better communications, diversions for employees, and the use of sniffer dogs, are discussed.

  3. antithyroid drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  4. antidiabetic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  5. antiretroviral drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  6. acute cutaneous drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  7. antipsychotic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  8. adverse drug events: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  9. adverse drug event: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  10. antiepileptic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  11. antiarrhythmic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  12. antiinflammatory drugs nsaids: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  13. acute drug intoxication: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  14. adhd drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  15. antihypertensive drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  16. alternative drug interaction: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brenda Fenton 230 The Crystal Structures of Psoralen Cross-linked DNAs: Drug-dependent Formation of Biology and Medicine Websites Summary: 12;The Crystal Structures of Psoralen...

  17. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Office of Environmental Management (EM)

    Stewardship and Cost Savings FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus....

  18. antimalarial drug artemisinin: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Isolation of Artemisinin as Antimalarial Drugs from Artemisia annua L. Cultivated in Indonesia CiteSeer Summary: Abstract-- Malaria disease is endemic in developing countries like...

  19. act drug policies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcoholic beverages. These standards conform to state and federal laws. The policy described in this brochure pertains to alcohol and other drug use behaviors in...

  20. anticancer drug analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    or preclinical development. Preeti Singh Sisodiya 2012-01-01 68 Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Computer Technologies and Information Sciences...

  1. Drug representatives: Giving you lunch or stealing your soul?

    E-Print Network [OSTI]

    Higgins, Steven P

    2007-01-01T23:59:59.000Z

    with pharmaceutical representatives are too useful topharmaceutical sales representatives. JAMA. 1995 Apr 26;273(Drug representatives: Giving you lunch or stealing your

  2. Revealing a Novel Mode of Action for an Osteoporosis Drug

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to APS Science Highlights rss feed Revealing a Novel Mode of Action for an Osteoporosis Drug August 13, 2014 Bookmark and Share Schematic of mechanical testing apparatus...

  3. anticancer drug levels: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Summary.-The effects of hormone and drug treatments on plasma prolactin (PRL) levels and mammary tumour growth were investigated in rats bearing continuously...

  4. antipsychotic drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 45 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  5. antihypertensive drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 28 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  6. anticancer drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 48 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  7. animal drugs change: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to many antibiotics. In an increasing number of cases, vancomycin is the only treatment drug that remains effective. Because E. faecium was untreatable with practically all...

  8. animal drug availability: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to many antibiotics. In an increasing number of cases, vancomycin is the only treatment drug that remains effective. Because E. faecium was untreatable with practically all...

  9. antidepressant drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 50 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  10. antiretroviral drug exposure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SKILLS AQUIRED THROUGH Auerbach, Scott M. 2 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  11. antiretroviral drugs arvs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on (more) Wilson, Kinsley Rose 2009-01-01 4 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  12. antiretroviral drug combination: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    carrying various combinations Ahlers, Guenter 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  13. antidepressant drug design: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ylenedioxymethamphetamine (MDMA) also known as Ecstasy is a common recreational drug of abuse and reports of abuse of tricyclic antidepressants are also known. We report two cases...

  14. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01T23:59:59.000Z

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  15. Intermittent Preventive Treatment (IPT) and the spread of drug ...

    E-Print Network [OSTI]

    2014-12-25T23:59:59.000Z

    drug resistant malaria. Miranda I. Teboh-Ewungkem, Olivia Prosper, Katharine Gurski, Carrie A. Manore, Angela Peace, and. Zhilan Feng. Abstract Intermittent...

  16. In silico modeling to predict drug-induced phospholipidosis

    SciTech Connect (OSTI)

    Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

    2013-06-01T23:59:59.000Z

    Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structureactivity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 8081% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. The training set data in the models is derived from the FDA's phospholipidosis database. We find excellent predictivity values of the models based on external validation. The models can support drug screening and regulatory decision-making on DIPL.

  17. Transdermal microconduits by microscission for drug delivery and sample acquisition

    E-Print Network [OSTI]

    Gonzalez, Salvador

    Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

  18. Detection of illegal drugs using passive infrared sensing

    SciTech Connect (OSTI)

    Bennett, C.L.; Carter, M.R.; Fields, D.J.

    1996-04-12T23:59:59.000Z

    This report summarizes results on experiments testing the feasibility of detecting illegal drugs using passive infrared spectroscopy in the 8-13 micrometer spectral band.

  19. antimalarial drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 30 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  20. antidepressant drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 39 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  1. avoiding drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 23 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  2. Adaptive wiener image restoration kernel

    DOE Patents [OSTI]

    Yuan, Ding (Henderson, NV)

    2007-06-05T23:59:59.000Z

    A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

  3. Scandinavian Workshop on Imaging

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Barcode Imaging of Chocolate Milk Quan.fica.on of Microstructures in Freeze.on of Fat Content in Raw Beef Cut Meat Evalua.on by RGB-to-spectrum Imaging.on to Visualizing Meat Products Characteriza.on of Commercial Danish Apple Cul.var Using Novel

  4. Heart imaging method

    DOE Patents [OSTI]

    Collins, H. Dale (Richland, WA); Gribble, R. Parks (Richland, WA); Busse, Lawrence J. (Littleton, CO)

    1991-01-01T23:59:59.000Z

    A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.

  5. DOUBLE MAJORS Imaging Science + ...

    E-Print Network [OSTI]

    Zanibbi, Richard

    DOUBLE MAJORS Imaging Science + ... Applied Mathematics Biomedical Sciences Computer Science Undergraduate Research Internships and Cooperative Education (Co-op) (optional) Study Abroad WHY IMAGING SCIENCE Science: BS, MS, PhD Color Science: MS, PhD BS + MS/PhD Combos HUMAN VISION BIO- MEDICAL ASTRO- PHYSICS

  6. Fluorescent image tracking velocimeter

    DOE Patents [OSTI]

    Shaffer, Franklin D. (Library, PA)

    1994-01-01T23:59:59.000Z

    A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

  7. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2012-07-24T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

  8. Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery

    E-Print Network [OSTI]

    Bagby, Taryn Rochelle

    2011-12-31T23:59:59.000Z

    Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

  9. T? tunable porous silicon iron oxide nanocomposites for magnetic resonance imaging guided drug delivey

    E-Print Network [OSTI]

    Ananda Yogendran, Shalini

    2012-01-01T23:59:59.000Z

    > y) & (0 z)) if (sqrt(pwr(x-xpos[sphere],2) + pwr (y-ypos[sphere],2)+pwr( z-zpos[sphere], 2)) <=sphere_radius) { int

  10. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  11. Time encoded radiation imaging

    DOE Patents [OSTI]

    Marleau, Peter; Brubaker, Erik; Kiff, Scott

    2014-10-21T23:59:59.000Z

    The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

  12. Confocal coded aperture imaging

    DOE Patents [OSTI]

    Tobin, Jr., Kenneth William (Harriman, TN); Thomas, Jr., Clarence E. (Knoxville, TN)

    2001-01-01T23:59:59.000Z

    A method for imaging a target volume comprises the steps of: radiating a small bandwidth of energy toward the target volume; focusing the small bandwidth of energy into a beam; moving the target volume through a plurality of positions within the focused beam; collecting a beam of energy scattered from the target volume with a non-diffractive confocal coded aperture; generating a shadow image of said aperture from every point source of radiation in the target volume; and, reconstructing the shadow image into a 3-dimensional image of the every point source by mathematically correlating the shadow image with a digital or analog version of the coded aperture. The method can comprise the step of collecting the beam of energy scattered from the target volume with a Fresnel zone plate.

  13. Drug interactions evaluation: An integrated part of risk assessment of therapeutics

    SciTech Connect (OSTI)

    Zhang, Lei; Reynolds, Kellie S.; Zhao, Ping [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States); Huang, Shiew-Mei, E-mail: shiewmei.huang@fda.hhs.go [Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (United States)

    2010-03-01T23:59:59.000Z

    Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance ( (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf)) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a 'Drug Development and Drug Interactions' website to provide up-to-date information regarding evaluation of drug interactions ( (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm080499.htm)). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process.

  14. Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs

    SciTech Connect (OSTI)

    Rosenfeldt, Hans, E-mail: hans.rosenfeldt@fda.hhs.go [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); Kropp, Timothy; Benson, Kimberly [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); Ricci, M. Stacey [Division of Biologic Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States); McGuinn, W. David; Verbois, S. Leigh [Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993 (United States)

    2010-03-01T23:59:59.000Z

    The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements.

  15. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    Policy Reform: How an Illegal Safer Injection Room Led toof African-Americans became illegal, the rise of punitiveby wealthy whites, such as illegal prescription drug use by

  16. Sandia National Laboratories: CSP Images & Videos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Images & Videos CSP Images & Videos Image Gallery Videos Concentrating Solar Power Image Gallery A picture says a thousand words, especially on the World Wide Web. Both Sandia...

  17. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  18. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  19. Ghost Imaging with Blackbody Radiation

    E-Print Network [OSTI]

    Yangjian Cai; Shiyao Zhu

    2004-07-29T23:59:59.000Z

    We present a theoretical study of ghost imaging by using blackbody radiation source. A Gaussian thin lens equation for the ghost imaging, which depends on both paths, is derived. The dependences of the visibility and quality of the image on the transverse size and temperature of the blackbody are studied. The main differences between the ghost imaging by using the blackbody radiation and by using the entangled photon pairs are image-forming equation, and the visibility and quality of the image

  20. Combined Illumination Cylindrical Millimeter-Wave Imaging Technique for Concealed Weapon Detection

    SciTech Connect (OSTI)

    Sheen, David M.; McMakin, Douglas L.; Hall, Thomas E.

    2000-04-01T23:59:59.000Z

    A novel millimeter-wave imaging technique has been developed for personnel surveillance applications, including the detection of concealed weapons, explosives, drugs, and other contraband material. Millimeter-waves are high-frequency radio waves in the frequency band of 30-300 GHz, and pose no health threat to humans at moderate power levels. These waves readily penetrate common clothing materials, and are reflected by the human body and by concealed items. The combined illumination cylindrical imaging concept consists of a vertical, high-resolution, millimeter-wave array of antennas which is scanned in a cylindrical manner about the person under surveillance. Using a computer, the data from this scan is mathematically reconstructed into a series of focused 3-D images of the person. After reconstruction, the images are combined into a single high-resolution three-dimensional image of the person under surveillance. This combined image is then rendered using 3-D computer graphics techniques. The combined cylindrical illumination is critical as it allows the display of information from all angles. This is necessary because millimeter-waves do not penetrate the body. Ultimately, the images displayed to the operator will be icon-based to protect the privacy of the person being screened. Novel aspects of this technique include the cylindrical scanning concept and the image reconstruction algorithm, which was developed specifically for this imaging system. An engineering prototype based on this cylindrical imaging technique has been fabricated and tested. This work has been sponsored by the Federal Aviation Administration (FAA).

  1. (WPI-iCeMS) Pure Nano Drugs*

    E-Print Network [OSTI]

    Takada, Shoji

    (WPI-iCeMS) SN-38 50 nm * Pure Nano Drugs* SN-38 10 HepG2* JST (-STEP Permeation and Retention (EPR)* EPR 20100 nm SN-38 SN-38 * SN-38 * SN-38 20 SN-38 Pure Nano Drugs

  2. Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery By Ji nanoparticles and drug molecules can be co- encapsulated in liposomes to simultaneously perform multiple and luminescent porous silicon nanoparticles to overcome such problems,[5,6] although these more complicated

  3. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-06T23:59:59.000Z

    The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

  4. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  5. Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List

    E-Print Network [OSTI]

    Oklahoma, University of

    Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List PLEASE READ: THIS DOCUMENT CONTAINS DrugList Blue MedicareRx (PDP)SM 2012 Formulary (List of Covered Drugs) DrugList PLEASE READ. Blue MedicareRx (PDP) is a stand-alone prescription drug plan with a Medicare contract offered by HCSC

  6. Drug-Free Workplace Program UT-B Contracts Page 1 of 1

    E-Print Network [OSTI]

    Pennycook, Steve

    Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

  7. Drug Resistance Updates 15 (2012) 9097 Contents lists available at SciVerse ScienceDirect

    E-Print Network [OSTI]

    Levy, Doron

    2012-01-01T23:59:59.000Z

    Drug Resistance Updates 15 (2012) 9097 Contents lists available at SciVerse ScienceDirect Drug Resistance Updates journal homepage: www.elsevier.com/locate/drup The dynamics of drug resistance Park, MD, USA a r t i c l e i n f o Keywords: Drug-dependent/independent resistance Drug scheduling

  8. Scanning computed confocal imager

    DOE Patents [OSTI]

    George, John S. (Los Alamos, NM)

    2000-03-14T23:59:59.000Z

    There is provided a confocal imager comprising a light source emitting a light, with a light modulator in optical communication with the light source for varying the spatial and temporal pattern of the light. A beam splitter receives the scanned light and direct the scanned light onto a target and pass light reflected from the target to a video capturing device for receiving the reflected light and transferring a digital image of the reflected light to a computer for creating a virtual aperture and outputting the digital image. In a transmissive mode of operation the invention omits the beam splitter means and captures light passed through the target.

  9. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

    1983-03-11T23:59:59.000Z

    It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

  10. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    SciTech Connect (OSTI)

    Li, Dongdong, E-mail: lidongchem@sina.cn [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Zhu, Yuntao; Liang, Zhiqiang [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)

    2013-06-01T23:59:59.000Z

    Highlights: ? The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ? The materials have high surface area and amino group. ? The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup ?}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  11. Statistical Agent Based Modelization of the Phenomenon of Drug Abuse

    E-Print Network [OSTI]

    Di Clemente, Riccardo; 10.1038/srep00532

    2012-01-01T23:59:59.000Z

    We introduce a statistical agent based model to describe the phenomenon of drug abuse and its dynamical evolution at the individual and global level. The agents are heterogeneous with respect to their intrinsic inclination to drugs, to their budget attitude and social environment. The various levels of drug use were inspired by the professional description of the phenomenon and this permits a direct comparison with all available data. We show that certain elements have a great importance to start the use of drugs, for example the rare events in the personal experiences which permit to overcame the barrier of drug use occasionally. The analysis of how the system reacts to perturbations is very important to understand its key elements and it provides strategies for effective policy making. The present model represents the first step of a realistic description of this phenomenon and can be easily generalized in various directions.

  12. NRC drug-free workplace plan. Revision 1

    SciTech Connect (OSTI)

    NONE

    1997-11-01T23:59:59.000Z

    On September 15, 1986, President Reagan signed Executive Order 12564, establishing the goal of a Drug-Free Federal Workplace. The Order made it a condition of employment that all Federal employees refrain from using illegal drugs on or off duty. On July 11, 1987, Congress passed legislation affecting implementation of the Executive Order under Section 503 of the Supplemental Appropriations Act of 1987, Public Law 100-71 (the Act). The Nuclear Regulatory Commission first issued the NRC Drug Testing Plan to set forth objectives, policies, procedures, and implementation guidelines to achieve a drug-free Federal workplace, consistent with the Executive Order and Section 503 of the Act. Revision 1, titled, ``NRC Drug-Free Workplace Plan,`` supersedes the previous version and its supplements and incorporates changes to reflect current guidance from the Department of Justice, the Department of Health and Human Services, as well as other guidance.

  13. Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture

    DOE Patents [OSTI]

    Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S.

    2013-01-08T23:59:59.000Z

    Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates.

  14. Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue 2.February 2010 155-159

    E-Print Network [OSTI]

    Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue of bioadhesivepolymersforlocalandsystemicdrugdeliveryformulations (1, 2). This is because these polymers can prolong the release of drug from dosage forms of the mucosa adhesive bond strength is essential for the successful application of bioadhesive drug delivery

  15. RIKEN Program for Drug Discovery and Medical Technology PlatformsRIKEN Program for Drug Discovery and Medical Technology Platforms Toshio Goto Program Director (D.Agr.)

    E-Print Network [OSTI]

    Fukai, Tomoki

    RIKEN Program for Drug Discovery and Medical Technology PlatformsRIKEN Program for Drug Discovery-2007, Associate Senior VP, Drug Discovery Research, Astellas. 2007-2009, Adviser, PGXIS. 2009-2010, Special Adviser, RIKEN, and 2010-present, Director, RIKEN Program for Drug Discovery and Medical Technology

  16. Image Content Engine (ICE)

    SciTech Connect (OSTI)

    Brase, J M

    2007-03-26T23:59:59.000Z

    The Image Content Engine (ICE) is being developed to provide cueing assistance to human image analysts faced with increasingly large and intractable amounts of image data. The ICE architecture includes user configurable feature extraction pipelines which produce intermediate feature vector and match surface files which can then be accessed by interactive relational queries. Application of the feature extraction algorithms to large collections of images may be extremely time consuming and is launched as a batch job on a Linux cluster. The query interface accesses only the intermediate files and returns candidate hits nearly instantaneously. Queries may be posed for individual objects or collections. The query interface prompts the user for feedback, and applies relevance feedback algorithms to revise the feature vector weighting and focus on relevant search results. Examples of feature extraction and both model-based and search-by-example queries are presented.

  17. Overview of Image Reconstruction

    SciTech Connect (OSTI)

    Marr, R.B.

    1980-04-01T23:59:59.000Z

    Image reconstruction (or computerized tomography, etc.) is any process whereby a function, f, on Rn is estimated from empirical data pertaining to its integrals, ∫f(x) dx, for some collection of hyperplanes of dimension k < n. The paper begins with background information on how image reconstruction problems have arisen in practice, and describes some of the application areas of past or current interest; these include radioastronomy, optics, radiology and nuclear medicine, electron microscopy, acoustical imaging, geophysical tomography, nondestructive testing, and NMR zeugmatography. Then the various reconstruction algorithms are discussed in five classes: summation, or simple back-projection; convolution, or filtered back-projection; Fourier and other functional transforms; orthogonal function series expansion; and iterative methods. Certain more technical mathematical aspects of image reconstruction are considered from the standpoint of uniqueness, consistency, and stability of solution. The paper concludes by presenting certain open problems. 73 references. (RWR)

  18. Photothermal imaging scanning microscopy

    DOE Patents [OSTI]

    Chinn, Diane (Pleasanton, CA); Stolz, Christopher J. (Lathrop, CA); Wu, Zhouling (Pleasanton, CA); Huber, Robert (Discovery Bay, CA); Weinzapfel, Carolyn (Tracy, CA)

    2006-07-11T23:59:59.000Z

    Photothermal Imaging Scanning Microscopy produces a rapid, thermal-based, non-destructive characterization apparatus. Also, a photothermal characterization method of surface and subsurface features includes micron and nanoscale spatial resolution of meter-sized optical materials.

  19. And Justice for All? Racial and Ethnic Disparities in Federal Drug Courts in California and the US

    E-Print Network [OSTI]

    Chen, Elsa; Nomura, Kevin

    2015-01-01T23:59:59.000Z

    Guideline Range of Sentence Drug Of- fense Cat- egorieswith regard to federal drug crime sentences in California.2003 Coef. e (SE) senting drug type, with crack, heroin,

  20. Restoring functional PET Images using Anatomical MR Images

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Restoring functional PET Images using Anatomical MR Images Peter Alshede Philipsen, Ulrik Kjems,uk,pto,lkh@imm.dtu.dk Abstract In this paper we present a Bayesian method to enhance functional 3D PET images using apriori as a true PET­MR result, and further more show how to obtain the desired information from the MR images. 1

  1. Reflective optical imaging system

    DOE Patents [OSTI]

    Shafer, David R. (Fairfield, CT)

    2000-01-01T23:59:59.000Z

    An optical system compatible with short wavelength (extreme ultraviolet) radiation comprising four reflective elements for projecting a mask image onto a substrate. The four optical elements are characterized in order from object to image as convex, concave, convex and concave mirrors. The optical system is particularly suited for step and scan lithography methods. The invention increases the slit dimensions associated with ringfield scanning optics, improves wafer throughput and allows higher semiconductor device density.

  2. Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications

    E-Print Network [OSTI]

    Edward, Jonathan M. (Jonathan Mark)

    2008-01-01T23:59:59.000Z

    Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

  3. Structure-based drug mechanism study and inhibitor design targeting tuberculosis

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    The increase of multi-drug resistant and extensively drug resistant tuberculosis (TB) cases makes it urgent to develop a new generation of TB drugs to counter resistance and shorten treatment. Structural biology, which ...

  4. The Drug Evaluation and Classification Program in the state of Texas: a validation study

    E-Print Network [OSTI]

    Walden, Troy Duane

    2005-08-29T23:59:59.000Z

    to determine if the procedures are reliable and whether a drug recognition expert (DRE) can properly apply the DECP procedures to consistently identify the drug category and have that opinion supported by toxicology. A total of 324 enforcement drug influence...

  5. Recovery from drug dependence : experiences of service users in a Christian faith-based agency

    E-Print Network [OSTI]

    Jinadu, Comfort Ablavi

    2012-11-28T23:59:59.000Z

    Research in the field of drug dependence and recovery emphasises the need for more understanding of the concept of recovery from dependent drug use. This study explored the ways in which dependent drug users recover from ...

  6. Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug

    E-Print Network [OSTI]

    Bey, Tareg; Patel, Anar

    2007-01-01T23:59:59.000Z

    Management of Poisoning and Drug Overdose. Philadelphia,patterns seen in street drug analysis. Clin Toxicol 1976; 9:Poklis A, Maginn D, Barr JL. Drug findings in Driving Under

  7. Access to drug abuse treatment under Treatment on Demand policy in San Francisco

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Wenger, L.D. ; Rosenbaum, M. Drug treatment on demandnot.J. Psychoactive Drugs 19. Yancovitz, S.R. ; Des Jarlais,332. 21. Office of National Drug Control Policy. National

  8. In Vivo and Functional Imaging in Developmental

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    of physiological performance, disrupt the system, for example with microinjec- tion of drugs or laser ablation

  9. BAYESIAN ENSEMBLE LEARNING FOR MEDICAL IMAGE DENOISING

    E-Print Network [OSTI]

    Oh, Hyuntaek

    2012-08-31T23:59:59.000Z

    Medical images are often affected by random noise because of both image acquisition from the medical modalities and image transmission from modalities to workspace in the main computer. Medical image denoising removes noise from the CT or MR images...

  10. E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

  11. E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  12. Drug Court Effectiveness: A Review of California Evaluation Reports, 1995-1999

    E-Print Network [OSTI]

    Guydish, Joseph R PhD; Wolfe, Ellen; Tajima, Barbara; Woods, William J

    2006-01-01T23:59:59.000Z

    Evaluation qfthe Oakland Drug Court Afur ?ue Ycan. Onklsnd.39; Journal JP:ydIurclive Drugs 378 - -. ~z. ~. ;- Sa;;n"IDrug Courl::

  13. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release

    E-Print Network [OSTI]

    Hoare, Todd

    Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on?off drug release upon application (and removal) ...

  14. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  15. Cellular responses against DNA damaged by platinum anticancer drugs

    E-Print Network [OSTI]

    Jung, Yongwon, 1977-

    2005-01-01T23:59:59.000Z

    The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...

  16. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01T23:59:59.000Z

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  17. Streamlining data management in drug product commercialization and manufacturing

    E-Print Network [OSTI]

    Anderson, Spencer C. (Spencer Clark)

    2014-01-01T23:59:59.000Z

    Effective execution and alignment of data management across development and manufacturing teams is essential for Amgen's Drug Product Technology group to realize its main goals of shortening the development timeline and ...

  18. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01T23:59:59.000Z

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  19. Near-infrared-actuated devices for remotely controlled drug delivery

    E-Print Network [OSTI]

    Timko, Brian P.

    A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage ...

  20. Rethinking drug policy: an integrity preserving compromise position

    E-Print Network [OSTI]

    Crispino, Azzurra

    2006-10-30T23:59:59.000Z

    The "War on Drugs" has been raging for twenty years without resolution. This work attempts to provide a compromise position between the prohibitionists and the legalizers that preserves the integrity of both positions. This compromise position...

  1. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  2. antidiabetic drugs present: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data to perform a number of econometric studies to assess the health and economic impacts of new drug development and use. I hypothesize that people may obtain several kinds...

  3. Alcohol, Tobacco, and Other Drug Use in Illinois: Prevalence

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    Assessment Program. Rod R. Blagojevich, Governor #12;#12;Alcohol, Tobacco, and Other Drug Use in Illinois by the federal Office of Management and Budget. Theodora Binion-Taylor, Associate Director 100 West Randolph

  4. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01T23:59:59.000Z

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  5. adherence drug concentrations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    abuse.Medication Adherence in HIV seropositive adults was associated with current drug abuseabuse, length of HIV illness, or number of years on HIV medications. 2007-01-01 11...

  6. antiretroviral drug fosamprenavir: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (0.08 m... Brouwers, Joachim 2006-10-25 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  7. Biosynthetic engineering for the assembly of better drugs

    E-Print Network [OSTI]

    Yadav, Vikramaditya Ganapati

    2013-01-01T23:59:59.000Z

    The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

  8. Stimuli Responsive Polymers for Enhanced Drug Release Applications

    E-Print Network [OSTI]

    Tam, Michael K. C.

    This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide- ...

  9. Annual Report 2010 Department of Drug and Natural Product Synthesis

    E-Print Network [OSTI]

    Compounds University PET-Diagnostics Pharmacy SSAO- Drug University of Inhibitors Research Teaching Appl.730; Category Chemistry; Inorganic&Nuclear: Rank 16/40] B. Datterl, N. Trstner, D. Kucharski, W. Holzer (2010

  10. Pulsatile Drug Delivery System Based on Electrohydrodynamic Method

    E-Print Network [OSTI]

    Zheng, Yi; Hu, Junqiang; Gao, Wenle

    2012-01-01T23:59:59.000Z

    Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsatile drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used to generate a single drug droplet as small as 2.83 nL in 8.5 ms with a total device of 2\\times2\\times3 mm^3, and an external supplied voltage of 1500 V. Theoretically, we derive the expressions for the size and the formation time of a droplet generated by EHD method, while taking into account the drug supply rate, properties of liquid, gap between two electrodes, nozzle size, and charged droplet neutralization. This work proves a repeatable, stable and controllable droplet generation and delivery system based on EHD method experimentally as well as theoretically.

  11. Microcapsule drug delivery device for treatment of glioblastoma multiforme

    E-Print Network [OSTI]

    Scott, Alexander Wesley

    2010-01-01T23:59:59.000Z

    Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

  12. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor,...

  13. Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

    E-Print Network [OSTI]

    Singh, Neetu

    Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we ...

  14. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

    E-Print Network [OSTI]

    Tong, Rong

    We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...

  15. Biocompatibility of an implantable ophthalmic drug delivery device

    E-Print Network [OSTI]

    Cohen, Sarah J. (Sarah Jennifer)

    2007-01-01T23:59:59.000Z

    Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

  16. antiangiogenic drug assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of 18 novel, anti-angiogenic 17- to 20-amino acid peptides Popel, Aleksander S. 10 Assessing malaria drug resistance in US military areas of operation using microarrays. Biology...

  17. Multispectral imaging probe

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Descour, M.R.; Armour, D.L.; Craig, M.J.; Richards-Kortum, R.

    1999-07-27T23:59:59.000Z

    A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector. 8 figs.

  18. Variable waveband infrared imager

    DOE Patents [OSTI]

    Hunter, Scott R.

    2013-06-11T23:59:59.000Z

    A waveband imager includes an imaging pixel that utilizes photon tunneling with a thermally actuated bimorph structure to convert infrared radiation to visible radiation. Infrared radiation passes through a transparent substrate and is absorbed by a bimorph structure formed with a pixel plate. The absorption generates heat which deflects the bimorph structure and pixel plate towards the substrate and into an evanescent electric field generated by light propagating through the substrate. Penetration of the bimorph structure and pixel plate into the evanescent electric field allows a portion of the visible wavelengths propagating through the substrate to tunnel through the substrate, bimorph structure, and/or pixel plate as visible radiation that is proportional to the intensity of the incident infrared radiation. This converted visible radiation may be superimposed over visible wavelengths passed through the imaging pixel.

  19. Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug

    E-Print Network [OSTI]

    Li, Meiyi, S.M. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    Nucleotide excision repair, a DNA repair mechanism, is the major repair pathway responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific ...

  20. Imaging agents for in vivo magnetic resonance and scintigraphic imaging

    DOE Patents [OSTI]

    Engelstad, B.L.; Raymond, K.N.; Huberty, J.P.; White, D.L.

    1991-04-23T23:59:59.000Z

    Methods are provided for in vivo magnetic resonance imaging and/or scintigraphic imaging of a subject using chelated transition metal and lanthanide metal complexes. Novel ligands for these complexes are provided. No Drawings

  1. Time-Encoded Imagers.

    SciTech Connect (OSTI)

    Marleau, Peter; Brubaker, Erik

    2014-11-01T23:59:59.000Z

    This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

  2. Wavelets in medical imaging

    SciTech Connect (OSTI)

    Zahra, Noor e; Sevindir, Huliya A.; Aslan, Zafar; Siddiqi, A. H. [Sharda University, SET, Department of Electronics and Communication, Knowledge Park 3rd, Gr. Noida (India); University of Kocaeli, Department of Mathematics, 41380 Kocaeli (Turkey); Istanbul Aydin University, Department of Computer Engineering, 34295 Istanbul (Turkey); Sharda University, SET, Department of Mathematics, 32-34 Knowledge Park 3rd, Greater Noida (India)

    2012-07-17T23:59:59.000Z

    The aim of this study is to provide emerging applications of wavelet methods to medical signals and images, such as electrocardiogram, electroencephalogram, functional magnetic resonance imaging, computer tomography, X-ray and mammography. Interpretation of these signals and images are quite important. Nowadays wavelet methods have a significant impact on the science of medical imaging and the diagnosis of disease and screening protocols. Based on our initial investigations, future directions include neurosurgical planning and improved assessment of risk for individual patients, improved assessment and strategies for the treatment of chronic pain, improved seizure localization, and improved understanding of the physiology of neurological disorders. We look ahead to these and other emerging applications as the benefits of this technology become incorporated into current and future patient care. In this chapter by applying Fourier transform and wavelet transform, analysis and denoising of one of the important biomedical signals like EEG is carried out. The presence of rhythm, template matching, and correlation is discussed by various method. Energy of EEG signal is used to detect seizure in an epileptic patient. We have also performed denoising of EEG signals by SWT.

  3. Fundamentals of Image Processing

    E-Print Network [OSTI]

    Erdem, Erkut

    Fourier transform Log power spectrum #12;Review - The Convolution Theorem The Fourier transform components Fourier (1807): Periodic functions could be represented as a weighted sum of sines and cosines Image courtesy of Technology Review #12;Review - Fourier Transform We want to understand

  4. \\NeuroImage" Informatics

    E-Print Network [OSTI]

    Nielsen, Finn ?rup

    International Neuroimaging Consortium Introduction Author cocitation analysis describes a scienti#12;c #12;eld on data collected by the Institute of Scien- ti#12;c Information among a limited set of key au- thors within a #12;eld. Here we work on data from a single journal (the journal \\NeuroImage") down- loaded from

  5. Drug testing Example for Conditional Probability and Bayes Theorem Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    for an illegal drug is such that it is 98% accurate in the case of a user of that drug (e.g. it produces and the test is positive. What is the probability that the tested individual uses this illegal drug? What

  6. Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

    E-Print Network [OSTI]

    De Micheli, Giovanni

    in the case of some pharmacological treatments based on drug regimens, such as anti-cancer drug therapies [2]. Etoposide is a widely used anti-cancer drug, administered for the treatment of many kinds of tumours [3, 4Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection S. Sara Ghoreishizadeh, Camilla Baj

  7. Ronald: A Domain-Specific Language to study the interactions between malaria infections and drug

    E-Print Network [OSTI]

    McBurney, Peter

    Ronald: A Domain-Specific Language to study the interactions between malaria infections and drug kills more than 1 million peo- ple a year, mostly children in sub-Saharan Africa. Antimalarial drug-Specific Language to model the fundamental forces driving antimalarial drug resistance including drug

  8. Employee Drug and Alcohol Abuse Policy #CofC.HR.DA.03 Revised 12/2001

    E-Print Network [OSTI]

    Kasman, Alex

    Policy Employee Drug and Alcohol Abuse Policy #CofC.HR.DA.03 Revised 12/2001 The Drug-Free Schools and Communities Act The Drug-Free School and Communities Act, Public Law 101-226, requires that as a condition, or distribution of illicit drugs and alcohol by students and employees. The College of Charleston has

  9. Topoisomerase II-Drug Interaction Domains: Identification of Substituents on Etoposide That Interact with the Enzyme

    E-Print Network [OSTI]

    Berkowitz, David

    Topoisomerase II-Drug Interaction Domains: Identification of Substituents on Etoposide chemotherapeutic agents used for the treatment of human cancers. The drug kills cells by inhibiting the ability, and a pendent ring (E-ring) at the C1 position. Although drug-enzyme contacts, as opposed to drug

  10. 276 Drug-FreePolicy University of Kentucky 2008-2009 Undergraduate Bulletin

    E-Print Network [OSTI]

    MacAdam, Keith

    276 Drug-FreePolicy University of Kentucky 2008-2009 Undergraduate Bulletin Drug-Free Policy Policy Statement as a Drug-Free Institution The University of Kentucky is committed to providing a healthy and safe to the unlawful possession, use, dispensa- tion, distribution or manufacture of alcohol or illicit drugs. Conduct

  11. Drug-evoked synaptic plasticity and addictive behavior, a causal relationship?

    E-Print Network [OSTI]

    Fukai, Tomoki

    Drug-evoked synaptic plasticity and addictive behavior, a causal relationship? Christian Luescher principal interest is on drug reward and how exposure to addictive substances can change behavior in rodent models of addiction. "Drug-evoked synaptic plasticity" has emerged as a mechanism underlying drug

  12. Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes

    E-Print Network [OSTI]

    Mather, Patrick T.

    Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes Qiongyu Guo a 2009 Keywords: POSS Biodegradable polymer Drug delivery Drug-eluting stents Highly adjustable and precisely controllable drug release from a biodegradable stent coating was achieved using a unique family

  13. Updated 2011-12 HEALTH AND BEHAVIORAL RISKS OF ALCOHOL AND DRUG USE

    E-Print Network [OSTI]

    Marsh, David

    Updated 2011-12 HEALTH AND BEHAVIORAL RISKS OF ALCOHOL AND DRUG USE The negative physical and mental effects of the use of alcohol and other drugs are well documented. Use of these drugs may cause including depression, psychosis, and severe anxiety. Risks associated with specific drugs are described

  14. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  15. Efficient MR image reconstruction for compressed MR imaging Junzhou Huang

    E-Print Network [OSTI]

    Huang, Junzhou

    to be very powerful for the MR image reconstruction. First, we decompose the original problem into L1 and TV.V. All rights reserved. 1. Introduction Magnetic Resonance (MR) imaging has been widely used in medical. Computation became the bottleneck that prevented this good model (1) from being used in practical MR image

  16. Efficient MR Image Reconstruction for Compressed MR Imaging

    E-Print Network [OSTI]

    Huang, Junzhou

    demonstrate the superior performance of the proposed algorithm for com- pressed MR image reconstruction. 1 [1][2] show that it is possi- ble to accurately reconstruct the Magnetic Resonance (MR) images from for real MR images. Computation became the bottleneck that prevented this good model (1) from being used

  17. Fluid Imaging of Enhanced Geothermal Systems

    Broader source: Energy.gov (indexed) [DOE]

    for Fluids & Fractures - time lapse MTCSEM for fluid imaging - joint CSEM-MTseismic imaging ??? - use MEQ focal information with EM Imaging ScientificTechnical Approach...

  18. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

    E-Print Network [OSTI]

    Xu, Jinghai J.

    Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration ...

  19. Fourier Analysis of Ghost Imaging

    E-Print Network [OSTI]

    Honglin Liu; Jing Cheng; Yanfeng Bai; Shensheng Han

    2006-09-28T23:59:59.000Z

    Fourier analysis of ghost imaging (FAGI) is proposed in this paper to analyze the properties of ghost imaging with thermal light sources. This new theory is compatible with the general correlation theory of intensity fluctuation and could explain some amazed phenomena. Furthermore we design a series of experiments to verify the new theory and investigate the inherent properties of ghost imaging.

  20. Automated Very Low Magnification Imaging

    E-Print Network [OSTI]

    of the entire available imaging area on the grid. The VLM image can then be used as a reference map of Illinois at Urbana- Champaign, Urbana, IL 61801. A typical TEM specimen grid provides approximately a 2x2 mm area that is available for imaging. In order to identify and locate suitable targets on the grid

  1. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  2. The use of carbon stable isotope ratios in drugs characterization

    SciTech Connect (OSTI)

    Magdas, D. A., E-mail: gabriela.cristea@itim-cj.ro; Cristea, G., E-mail: gabriela.cristea@itim-cj.ro; Bot, A., E-mail: gabriela.cristea@itim-cj.ro; Mirel, V., E-mail: gabriela.cristea@itim-cj.ro [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Str., 400293 Cluj-Napoca (Romania)

    2013-11-13T23:59:59.000Z

    Isotopic Ratio Mass Spectrometry (IRMS) is an effective toll to be used for drug product authentication. The isotopic composition could be used to assist in the differentiation between batches of drugs and assist in the identification of counterfeit materials on the market. Only two factors affect the isotopic ratios in pharmaceutical components: the isotopic composition of the raw materials and the synthetic processes performed upon them. Counterfeiting of pharmaceutical drugs threatens consumer confidence in drug products companies' economical well-being. In this preliminary study, the analyzed samples consist in two types of commercially available analgesics, which were purchases from Romanian pharmacies. Differences in ?{sup 13}C between batches from ?29.7 to ?31.6% were observed, demonstrating that this method can be used to differentiate among individual drug batches and subsequently identify counterfeits on the market. On the other hand, carbon isotopic ratios differences among producers were recorded, the variations being between ?31.3 to ?34.9% for the same type of analgesic, but from different manufactures.

  3. Alcohol and Drug Abuse Education Programs The University has developed a program to prevent the illicit use of drugs and the abuse of

    E-Print Network [OSTI]

    Escher, Christine

    Alcohol and Drug Abuse Education Programs The University has developed a program to prevent the illicit use of drugs and the abuse of alcohol by students and employees. The program provides services related to drug use and abuse including dissemination of informational materials, educational programs

  4. Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to

    E-Print Network [OSTI]

    Minnesota, University of

    Why is the drug praziquantel effective in the treatment of parasitic flatworms? Praziquantel (PZQ) is the drug most commonly used in humans and livestock to fight the disease schistosomiasis, an infection.S., et al, 1983; Ismail M. et al, 1999). There is evidence that the mechanism of the drug has to do

  5. 2013-2014 Annual Notification of Alcohol and Other Drug Information Page 1 2013-2014 Annual Notification of Alcohol and Other Drug Information

    E-Print Network [OSTI]

    Tullos, Desiree

    2013-2014 Annual Notification of Alcohol and Other Drug Information Page 1 2013-2014 Annual Notification of Alcohol and Other Drug Information OSU is required by law to notify annually all students, staff, and faculty of alcohol and other drug policies, sanctions, and risks associated with use

  6. Acoustic imaging microscope

    DOE Patents [OSTI]

    Deason, Vance A.; Telschow, Kenneth L.

    2006-10-17T23:59:59.000Z

    An imaging system includes: an object wavefront source and an optical microscope objective all positioned to direct an object wavefront onto an area of a vibrating subject surface encompassed by a field of view of the microscope objective, and to direct a modulated object wavefront reflected from the encompassed surface area through a photorefractive material; and a reference wavefront source and at least one phase modulator all positioned to direct a reference wavefront through the phase modulator and to direct a modulated reference wavefront from the phase modulator through the photorefractive material to interfere with the modulated object wavefront. The photorefractive material has a composition and a position such that interference of the modulated object wavefront and modulated reference wavefront occurs within the photorefractive material, providing a full-field, real-time image signal of the encompassed surface area.

  7. Multimode imaging device

    DOE Patents [OSTI]

    Mihailescu, Lucian; Vetter, Kai M

    2013-08-27T23:59:59.000Z

    Apparatus for detecting and locating a source of gamma rays of energies ranging from 10-20 keV to several MeV's includes plural gamma ray detectors arranged in a generally closed extended array so as to provide Compton scattering imaging and coded aperture imaging simultaneously. First detectors are arranged in a spaced manner about a surface defining the closed extended array which may be in the form a circle, a sphere, a square, a pentagon or higher order polygon. Some of the gamma rays are absorbed by the first detectors closest to the gamma source in Compton scattering, while the photons that go unabsorbed by passing through gaps disposed between adjacent first detectors are incident upon second detectors disposed on the side farthest from the gamma ray source, where the first spaced detectors form a coded aperture array for two or three dimensional gamma ray source detection.

  8. Imaging the Antikythera Mechanism

    SciTech Connect (OSTI)

    Malzbender, Tom (Hewlett Packard Laboratories) [Hewlett Packard Laboratories

    2011-01-12T23:59:59.000Z

    In 1900, a party of sponge divers chanced on the wreck of a Roman merchant vessel between Crete and mainland Greece. It was found to contain numerous ancient Greek treasures, among them a mysterious lump of clay that split open to reveal 'mathematical gears' as it dried out. This object is now known as the Antikythera Mechanism, one of the most enlightening artifacts in terms of revealing the advanced nature of ancient Greek science and technology. In 2005 we travelled to the National Archeological Museum in Athens to apply our Reflectance Imaging methods to the mechanism in the hopes of revealing ancient writing on the device. We were successful, and along with the results of Microfocus CT imaging, we are able to decipher 3000 characters compared with the original 800 known. This lead to an understanding that the device was a mechanical, astronomical computer from 150 B.C.E. capable of predicting solar and lunar eclipses along with other celestial events. This talk will overview both the imaging methods as well as what they reveal about the Antikythera Mechanism.

  9. X-ray Spectroscopy for Quality Control of Chemotherapy Drugs

    SciTech Connect (OSTI)

    Greaves, E. D.; Barros, H.; Bermudez, J.; Sajo-Bohus, L. [Universidad Simon Bolivar, Apartado 89000, Caracas 1080A (Venezuela); Angeli-Greaves, M. [Universidad Central de Venezuela, Apartado 90373 Caracas 1083A (Venezuela)

    2007-10-26T23:59:59.000Z

    We develop a method, employing Compton peak standardization and the use of matrix-matched spiked samples with Total Reflection X-ray Fluorescence (TXRF), for the determination of platinum plasma concentrations of patients undergoing chemotherapy with Pt-bearing drugs. Direct blood plasma analysis attains Pt detection limits of 70 ng/ml. Measurement results of prescribed drug doses are compared to achieved blood Pt concentrations indicating a lack of expected correlations. Direct analysis of Pt-containing infused drugs from a variety of suppliers indicates cases of abnormal concentrations which raises quality control issues. We demonstrate the potential usefulness of the method for pharmacokinetic studies or for routine optimization and quality control of Pt chemotherapy treatments.

  10. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  11. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  12. Fiducial marker for correlating images

    DOE Patents [OSTI]

    Miller, Lisa Marie (Rocky Point, NY); Smith, Randy J. (Wading River, NY); Warren, John B. (Port Jefferson, NY); Elliott, Donald (Hampton Bays, NY)

    2011-06-21T23:59:59.000Z

    The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains.

  13. Speckle-free laser imaging

    E-Print Network [OSTI]

    Redding, Brandon; Cao, Hui

    2011-01-01T23:59:59.000Z

    Many imaging applications require increasingly bright illumination sources, motivating the replacement of conventional thermal light sources with light emitting diodes (LEDs), superluminescent diodes (SLDs) and lasers. Despite their brightness, lasers and SLDs are poorly suited for full-field imaging applications because their high spatial coherence leads to coherent artifacts known as speckle that corrupt image formation. We recently demonstrated that random lasers can be engineered to provide low spatial coherence. Here, we exploit the low spatial coherence of specifically-designed random lasers to perform speckle-free full-field imaging in the setting of significant optical scattering. We quantitatively demonstrate that images generated with random laser illumination exhibit higher resolution than images generated with spatially coherent illumination. By providing intense laser illumination without the drawback of coherent artifacts, random lasers are well suited for a host of full-field imaging applicatio...

  14. Bistatic SAR: Imagery & Image Products.

    SciTech Connect (OSTI)

    Yocky, David A.; Wahl, Daniel E.; Jakowatz, Charles V,

    2014-10-01T23:59:59.000Z

    While typical SAR imaging employs a co-located (monostatic) RADAR transmitter and receiver, bistatic SAR imaging separates the transmitter and receiver locations. The transmitter and receiver geometry determines if the scattered signal is back scatter, forward scatter, or side scatter. The monostatic SAR image is backscatter. Therefore, depending on the transmitter/receiver collection geometry, the captured imagery may be quite different that that sensed at the monostatic SAR. This document presents imagery and image products formed from captured signals during the validation stage of the bistatic SAR research. Image quality and image characteristics are discussed first. Then image products such as two-color multi-view (2CMV) and coherent change detection (CCD) are presented.

  15. Staring 2-D hadamard transform spectral imager

    DOE Patents [OSTI]

    Gentry, Stephen M. (Albuquerque, NM); Wehlburg, Christine M. (Albuquerque, NM); Wehlburg, Joseph C. (Albuquerque, NM); Smith, Mark W. (Albuquerque, NM); Smith, Jody L. (Albuquerque, NM)

    2006-02-07T23:59:59.000Z

    A staring imaging system inputs a 2D spatial image containing multi-frequency spectral information. This image is encoded in one dimension of the image with a cyclic Hadamarid S-matrix. The resulting image is detecting with a spatial 2D detector; and a computer applies a Hadamard transform to recover the encoded image.

  16. Device for wavelength-selective imaging

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2010-09-14T23:59:59.000Z

    An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.

  17. A numerical study of the phase behaviors of drug particle/star triblock copolymer mixtures in dilute solutions for drug carrier application

    SciTech Connect (OSTI)

    Wang, Shanhui; Tong, Chaohui; Zhu, Yuejin, E-mail: zhuyuejin@nbu.edu.cn [Department of Physics, Ningbo University, Ningbo 315211 (China)] [Department of Physics, Ningbo University, Ningbo 315211 (China)

    2014-04-14T23:59:59.000Z

    The complex microstructures of drug particle/ABA star triblock copolymer in dilute solutions have been investigated by a theoretical approach which combines the self-consistent field theory and the hybrid particle-field theory. Simulation results reveal that, when the volume fraction of drug particles is smaller than the saturation concentration, the drug particle encapsulation efficiency is 100%, and micelle loading capacity increases with increasing particle volume fraction. When the volume fraction of drug particles is equal to the saturation concentration, the micelles attain the biggest size, and micelle loading capacity reaches a maximum value which is independent of the copolymer volume fraction. When the volume fraction of drug particles is more than the saturation concentration, drug particle encapsulation efficiency decreases with increasing volume fraction of drug particles. Furthermore, it is found that the saturation concentration scales linearly with the copolymer volume fraction. The above simulation results are in good agreement with experimental results.

  18. 304 IEEE TRANSACTIONS ON NANOBIOSCIENCE, VOL. 12, NO. 4, DECEMBER 2013 In Vitro and In Vivo Imaging of Peptide-Encapsulated

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    developed as a vehicle for the targeted delivery of the cancer drug doxorubicin (DOX) to treat breast malignancy. Cathepsin D, a breast cancer cell secretion enzyme, triggered the release of DOX by digesting models was obtained using in vivo ultrasound imaging. The fluorescent profile of DOX was used as a means

  19. A matter of collection and detection for intraoperative and noninvasive near-infrared fluorescence molecular imaging: To see or not to see?

    SciTech Connect (OSTI)

    Zhu, Banghe; Rasmussen, John C.; Sevick-Muraca, Eva M., E-mail: Eva.Sevick@uth.tmc.edu [Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas 77030 (United States)

    2014-02-15T23:59:59.000Z

    Purpose: Although fluorescence molecular imaging is rapidly evolving as a new combinational drug/device technology platform for molecularly guided surgery and noninvasive imaging, there remains no performance standards for efficient translation of first-in-humans fluorescent imaging agents using these devices. Methods: The authors employed a stable, solid phantom designed to exaggerate the confounding effects of tissue light scattering and to mimic low concentrations (nMpM) of near-infrared fluorescent dyes expected clinically for molecular imaging in order to evaluate and compare the commonly used charge coupled device (CCD) camera systems employed in preclinical studies and in human investigational studies. Results: The results show that intensified CCD systems offer greater contrast with larger signal-to-noise ratios in comparison to their unintensified CCD systems operated at clinically reasonable, subsecond acquisition times. Conclusions: Camera imaging performance could impact the success of future first-in-humans near-infrared fluorescence imaging agent studies.

  20. Associated particle imaging (API)

    SciTech Connect (OSTI)

    NONE

    1998-05-01T23:59:59.000Z

    Associated Particle Imaging (API) is an active neutron probe technique that provides a 3-D image with elemental composition of the material under interrogation, and so occupies a unique niche in the interrogation of unknown objects. The highly penetrating nature of neutrons enables API to provide detailed information about targets of interest that are hidden from view. Due to the isotropic nature of the induced reactions, radiation detectors can be set on the same side of the object as the neutron source, so that the object can be interrogated from a single side. At the heat of the system is a small generator that produces a continuous, monoenergetic flux of neutrons. By measuring the trajectory of coincident alpha particles that are produced as part of the process, the trajectory of the neutron can be inferred. Interactions between a neutron and the material in its path often produce a gamma ray whose energy is characteristic of that material. When the gamma ray is detected, its energy is measured and combined with the trajectory information to produce a 3-D image of the composition of the object being interrogated. During the course of API development, a number of improvements have been made. A new, more rugged sealed Tube Neutron Generator (STNG) has been designed and fabricated that is less susceptible to radiation damage and better able to withstand the rigors of fielding than earlier designs. A specialized high-voltage power supply for the STNG has also been designed and built. A complete package of software has been written for the tasks of system calibration, diagnostics and data acquisition and analysis. A portable system has been built and field tested, proving that API can be taken out of the lab and into real-world situations, and that its performance in the field is equal to that in the lab.

  1. Superconductive imaging surface magnetometer

    DOE Patents [OSTI]

    Overton, Jr., William C. (Los Alamos, NM); van Hulsteyn, David B. (Santa Fe, NM); Flynn, Edward R. (Los Alamos, NM)

    1991-01-01T23:59:59.000Z

    An improved pick-up coil system for use with Superconducting Quantum Interference Device gradiometers and magnetometers involving the use of superconducting plates near conventional pick-up coil arrangements to provide imaging of nearby dipole sources and to deflect environmental magnetic noise away from the pick-up coils. This allows the practice of gradiometry and magnetometry in magnetically unshielded environments. One embodiment uses a hemispherically shaped superconducting plate with interior pick-up coils, allowing brain wave measurements to be made on human patients. another embodiment using flat superconducting plates could be used in non-destructive evaluation of materials.

  2. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, Hal O. (Berkeley, CA); Martin, Donn C. (Berkeley, CA); Lampton, Michael L. (Berkeley, CA)

    1983-01-01T23:59:59.000Z

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

  3. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, H.O.; Martin, D.C.; Lampton, M.L.

    1983-07-26T23:59:59.000Z

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally. 15 figs.

  4. Drug addiction encompasses a relapsing cycle of intoxi-cation, bingeing, withdrawal and craving that results in

    E-Print Network [OSTI]

    Homes, Christopher C.

    Drug addiction encompasses a relapsing cycle of intoxi- cation, bingeing, withdrawal and craving that results in excessive drug use despite adverse consequences (FIG. 1). Drugs that are abused by humans) -- a syndrome that is char- acterized by attributing excessive salience to the drug and drug-related cues

  5. Optimisation of cancer drug treatments using cell population dynamics

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Optimisation of cancer drug treatments using cell population dynamics Frederique Billy1 , Jean. The constraints at stake, met everyday in the clinic of cancers, are related mainly to resistance to treatment models used in cancer treatment in the last decades, together with the biological phenomena that can

  6. Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug

    E-Print Network [OSTI]

    Zhang, Liangfang

    Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery Santosh Aryal, Che be further es- terified with carboxyl or acid anhydride groups to provide different functionality. Ang et al the synthesis of novel acid-responsive therapeutic nanoparticles (NPs) with sub-100 nm size consisting

  7. Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy

    E-Print Network [OSTI]

    Pfeifer, Holger

    Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy Chemotherapy is still the backbone of today's cancer treatment. This is exemplified by acute myeloid leukemia (AML generation anti-leukemia treatments. The results have been published in the Journal of Advanced Healthcare

  8. anticancer drugs infusion: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    anticancer drugs infusion First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Pharmacokinetic Scaling of...

  9. Nearly all current drugs for osteoporosis act by inhibiting the

    E-Print Network [OSTI]

    for the development of osteoporosis in post-menopausal women. Control mice developed an osteopaenia, whereas mice fedNearly all current drugs for osteoporosis act by inhibiting the resorption of bone, and novel or reverse this disease in rodents. Osteoporosis is characterized by decreased bone density and strength

  10. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  11. Metabolic Regulation and Anticancer Drug Resistance in the Yeast

    E-Print Network [OSTI]

    Metabolic Regulation and Anticancer Drug Resistance in the Yeast Saccharomyces cerevisiae Mattias-91-576-8059-4 2014 Mattias Carlsson, Uppsala Print: SLU Service/Repro, Uppsala 2014 #12;Metabolic Regulation regulation by the yeast Rph1p protein, a zinc finger transcription factor which also contains a jmjC domain

  12. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  13. Rigor Through the Lens of Drug Discovery and Development

    E-Print Network [OSTI]

    flavors of incentives: economic, social, and moral. Academic and Industrial cultures/ incentivesRigor Through the Lens of Drug Discovery and Development The game Culture and incentives Our and development? Resources: Money, time, and access to multiple non-academic skill sets Incentives/ Culture

  14. (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs

    E-Print Network [OSTI]

    Weber, David J.

    (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs and Devices During Clinical Research Ryan Meade, JD Meade & Roach, LLP July 15, 2008 Baltimore, Maryland University of Maryland School of Medicine #12;(c) Meade & Roach, LLP 2 Overview Theme: Understanding Medicare reimbursement helps

  15. Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

    E-Print Network [OSTI]

    .0 BACKGROUND AND PURPOSE Mines is committed to protecting the health, safety and well-being of all employees significant health, safety and well-being concerns within the Mines working and learning environment. 1 Institutional Alcohol Policy. #12;Drug-free Workplace Policy Responsible Administrative Unit: Human Resources

  16. Stress, Risk Taking, Alcohol/Drugs, and Parents as Partners

    E-Print Network [OSTI]

    Stowell, Michael

    college Particular Interests Alcohol and other drug abuse Prescription stimulant abuse Marijuana) developmental stage Need to take risks in order to grow Frontal part of brain not fully developed Thinking is inevitable and represents a great learning opportunity Hard to truly grow without setbacks

  17. Drug release from hydrazone-containing peptide amphiphiles

    SciTech Connect (OSTI)

    Matson, John B.; Stupp, Samuel I. (NWU)

    2012-03-15T23:59:59.000Z

    Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine E-amine allowed for precise placement of a hydrazide in a peptide sequence.

  18. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  19. Integrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu

    E-Print Network [OSTI]

    Babu, M. Madan

    .com Bioinformatics Bioinformatics, a term coined for the applications of computer science in biology is now emerging., Bioinformatics plays an important role for the integration of broad disciplines of Biology to understandIntegrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu Centre

  20. Fourier plane image amplifier

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Hermann, Mark R. (San Ramon, CA); Dane, C. Brent (Livermore, CA); Tiszauer, Detlev H. (Tracy, CA)

    1995-01-01T23:59:59.000Z

    A solid state laser is frequency tripled to 0.3 .mu.m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only .about.1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power.

  1. Fourier plane image amplifier

    DOE Patents [OSTI]

    Hackel, L.A.; Hermann, M.R.; Dane, C.B.; Tiszauer, D.H.

    1995-12-12T23:59:59.000Z

    A solid state laser is frequency tripled to 0.3 {micro}m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only about 1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power. 1 fig.

  2. Topics in genomic image processing

    E-Print Network [OSTI]

    Hua, Jianping

    2006-04-12T23:59:59.000Z

    : : : : : : : : : : : : : : : : : 10 A. Wavelet-based Medical Image Coding Schemes and M- FISH Image Compression . . . . . . . . . . . . . . . . . . . 10 B. Embedded M-FISH Image Coding (EMIC) . . . . . . . . . 12 1. Segmentation and Shape Coding . . . . . . . . . . . . 13 2. Integer... Wavelet Transform . . . . . . . . . . . . . . . 14 a. 2-D Shape-adaptive Integer Wavelet Transform . 14 b. 3-D Integer Wavelet Transform Structure . . . . . 15 3. Fractional Bit-plane Coding . . . . . . . . . . . . . . . 16 a. Object-based Coding...

  3. Document Imaging | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Imaging Converting Paper Documents into Electronic Files Converting paper documents into electronic files helps us manage, store, access and archive the organizational information...

  4. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    this technique has been especially popular in imaging such complex structures as aerogels and yeast cells. When applying the CDI technique to a magnetic system, the same...

  5. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  6. Application of Parallel Imaging to Murine Magnetic Resonance Imaging

    E-Print Network [OSTI]

    Chang, Chieh-Wei 1980-

    2012-09-21T23:59:59.000Z

    . This dissertation describes foundational level work to enable parallel imaging of mice on a 4.7 Tesla/40 cm bore research scanner. Reducing the size of the hardware setup associated with typical parallel imaging was an integral part of achieving the work, as animal...

  7. Exploring Interaction Between Images and Texts for Web Image Categorization

    E-Print Network [OSTI]

    Li, Tao

    , Jingxuan Li1 , Tao Li1 1 School of Computing and Information Sciences Florida International University on a manually collected image dataset (consist- ing of images related to the events after disasters) demon users in mul- timedia databases is becoming more and more difficult and challenging. Particulary, web

  8. Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.; Jacobs, Damon T.; Forrest, M. Laird; Krise, Jeffrey P.

    2010-09-09T23:59:59.000Z

    previously described a concept for a novel drug delivery platform that relies on the propensity of drugs with optimal physicochemical properties to distribute differently in normal versus cancer cells due to differences in intracellular pH gradients...

  9. Medical data mining : improving information accessibility using online patient drug reviews

    E-Print Network [OSTI]

    Li, Yueyang Alice

    2011-01-01T23:59:59.000Z

    We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

  10. Changes in the characteristics of approved New Drug Applications for antihypertensives

    E-Print Network [OSTI]

    MacNeil, John Simon Howe

    2007-01-01T23:59:59.000Z

    In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

  11. Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON

    E-Print Network [OSTI]

    Fernandez, Eduardo

    Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

  12. DEVELOPMENTAL REGULATION OF THE DRUG-PROCESSING GENOME IN MOUSE LIVER

    E-Print Network [OSTI]

    Cui, Yue

    2010-07-29T23:59:59.000Z

    Despite the recent progress in understanding the expression patterns and regulatory mechanisms of drug-processing genes, namely phase-I and -II drug metabolizing enzymes and transporters in adults, very little is known of ...

  13. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil

    E-Print Network [OSTI]

    Fonseca, Elize Massard da

    2011-12-09T23:59:59.000Z

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was introduced in 1999. This policy...

  14. Reforming pharmaceutical regulation: a case study of generic drugs in Brazil

    E-Print Network [OSTI]

    Fonseca, Elize Massard

    2012-06-29T23:59:59.000Z

    Brazil is renowned worldwide for its remarkable reforms in pharmaceutical regulation, which have enhanced access to essential medicines while lowering drug costs. As part of these reforms, the Generic Drug Act was ...

  15. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  16. FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

  17. Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer

    E-Print Network [OSTI]

    Pathi, Satya

    2012-10-19T23:59:59.000Z

    Non-steroidal anti-inflammatory drugs (NSAIDs) and their NO derivatives (NO-NSAIDs), and synthetic analogs are highly effective as anticancer agents that exhibit relatively low toxicity compared to most clinically used drugs. However, the mechanisms...

  18. The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies

    E-Print Network [OSTI]

    DeMonaco, Harold J.

    2005-09-23T23:59:59.000Z

    Objective: To determine, through a review of the medical literature and author contact, the role of clinicians in the discovery of off label use of Food and Drug Administration approved prescription drugs.

  19. Access to Sterile Syringes through San Francisco Pharmacies and the Association with HIV Risk Behavior among Injection Drug Users

    E-Print Network [OSTI]

    Riley, Elise D.; Kral, Alex H.; Stopka, Thomas J.; Garfein, Richard S.; Reuckhaus, Paul; Bluthenthal, Ricky N.

    2010-01-01T23:59:59.000Z

    packets to increase injection drug users access to sterileBehavior among Injection Drug Users Elise D. Riley, Alex H.syringes among injection drug users (IDUs) and estimated

  20. Expert Opin Drug Metab Toxicol . Author manuscript The influence of pharmacogenetics and cofactors on clinical outcomes in

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Expert Opin Drug Metab Toxicol . Author manuscript Page /1 12 The influence of pharmacogenetics Abstract Introduction Immunosuppressive drugs have a narrow therapeutic range ; Cytochrome P-450 CYP3A ; genetics ; Dose-Response Relationship, Drug ; Enzyme Inhibitors ; pharmacokinetics

  1. A Juarez drug lord saved my life. Confessions of an accidental narco

    E-Print Network [OSTI]

    Cruz Rosas, Monica

    2013-01-01T23:59:59.000Z

    Organizations: Sinaloa Cartel West Texas High Intensity Drugarchive/ndic/dmas/West_Texas_DMA-2011(U).pdf Drug

  2. E-Print Network 3.0 - antiretroviral drug costs Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

  3. ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus

    Broader source: Energy.gov [DOE]

    FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

  4. Optical instrument for measurement of vaginal coating thickness by drug delivery formulations

    SciTech Connect (OSTI)

    Henderson, Marcus H.; Peters, Jennifer J.; Walmer, David K.; Couchman, Grace M.; Katz, David F. [Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 (United States); Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina 27710 (United States); Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 and Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina 27710 (United States)

    2005-03-01T23:59:59.000Z

    An optical device has been developed for imaging the human vaginal epithelial surfaces, and quantitatively measuring distributions of coating thickness of drug delivery formulations - such as gels - applied for prophylaxis, contraception or therapy. The device consists of a rigid endoscope contained within a 27-mm-diam hollow, polished-transparent polycarbonate tube (150 mm long) with a hemispherical cap. Illumination is from a xenon arc. The device is inserted into, and remains stationary within the vagina. A custom gearing mechanism moves the endoscope relative to the tube, so that it views epithelial surfaces immediately apposing its outer surface (i.e., 150 mm long by 360 deg. azimuthal angle). Thus, with the tube fixed relative to the vagina, the endoscope sites local regions at distinct and measurable locations that span the vaginal epithelium. The returning light path is split between a video camera and photomultiplier. Excitation and emission filters in the light path enable measurement of fluorescence of the sited region. Thus, the instrument captures video images simultaneously with photometric measurement of fluorescence of each video field [{approx}10 mm diameter; formulations are labeled with 0.1% w/w United States Pharmacoepia (USP) injectable sodium fluorescein]. Position, time and fluorescence measurements are continuously displayed (on video) and recorded (to a computer database). The photomultiplier output is digitized to quantify fluorescence of the endoscope field of view. Quantification of the thickness of formulation coating of a surface sited by the device is achieved due to the linear relationship between thickness and fluorescence intensity for biologically relevant thin layers (of the order of 0.5 mm). Summary measures of coating have been developed, focusing upon extent, location and uniformity. The device has begun to be applied in human studies of model formulations for prophylaxis against infection with HIV and other sexually transmitted pathogens.

  5. Processing Visual Images

    SciTech Connect (OSTI)

    Litke, Alan (UC Santa Cruz) [UC Santa Cruz

    2006-03-27T23:59:59.000Z

    The back of the eye is lined by an extraordinary biological pixel detector, the retina. This neural network is able to extract vital information about the external visual world, and transmit this information in a timely manner to the brain. In this talk, Professor Litke will describe a system that has been implemented to study how the retina processes and encodes dynamic visual images. Based on techniques and expertise acquired in the development of silicon microstrip detectors for high energy physics experiments, this system can simultaneously record the extracellular electrical activity of hundreds of retinal output neurons. After presenting first results obtained with this system, Professor Litke will describe additional applications of this incredible technology.

  6. Imaging synthetic aperture radar

    DOE Patents [OSTI]

    Burns, Bryan L. (Tijeras, NM); Cordaro, J. Thomas (Albuquerque, NM)

    1997-01-01T23:59:59.000Z

    A linear-FM SAR imaging radar method and apparatus to produce a real-time image by first arranging the returned signals into a plurality of subaperture arrays, the columns of each subaperture array having samples of dechirped baseband pulses, and further including a processing of each subaperture array to obtain coarse-resolution in azimuth, then fine-resolution in range, and lastly, to combine the processed subapertures to obtain the final fine-resolution in azimuth. Greater efficiency is achieved because both the transmitted signal and a local oscillator signal mixed with the returned signal can be varied on a pulse-to-pulse basis as a function of radar motion. Moreover, a novel circuit can adjust the sampling location and the A/D sample rate of the combined dechirped baseband signal which greatly reduces processing time and hardware. The processing steps include implementing a window function, stabilizing either a central reference point and/or all other points of a subaperture with respect to doppler frequency and/or range as a function of radar motion, sorting and compressing the signals using a standard fourier transforms. The stabilization of each processing part is accomplished with vector multiplication using waveforms generated as a function of radar motion wherein these waveforms may be synthesized in integrated circuits. Stabilization of range migration as a function of doppler frequency by simple vector multiplication is a particularly useful feature of the invention; as is stabilization of azimuth migration by correcting for spatially varying phase errors prior to the application of an autofocus process.

  7. Geosciences 466/566 Digital Image Processing

    E-Print Network [OSTI]

    Wright, Dawn Jeannine

    Geosciences 466/566 Digital Image Processing Winter 2007 Instructor Dr. Anne Nolin Wilkinson 120 This course focuses on the digital image processing of satellite image data. Topics include: data types, image://my.oregonstate.edu Textbook Jensen, J. R., Digital Image Processing: A Remote Sensing Perspective, 3rd Edition, Prentice Hall

  8. Simultaneous acquisition of differing image types

    DOE Patents [OSTI]

    Demos, Stavros G

    2012-10-09T23:59:59.000Z

    A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. A method in one embodiment includes receiving an image from an image forming device; decomposing the image formed by the image forming device into multiple component parts based on type of imaging; receiving the component parts of the image; and outputting image information based on the component parts of the image. Additional systems and methods are presented.

  9. CABM Symposium Applications of NMR to structure-based drug design in structural

    E-Print Network [OSTI]

    Powers, Robert

    CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

  10. Modulation of Drug Transport Properties by Multicomponent Diffusion in Surfactant Aqueous Solutions

    E-Print Network [OSTI]

    Annunziata, Onofrio

    Modulation of Drug Transport Properties by Multicomponent Diffusion in Surfactant Aqueous Solutions ReceiVed July 1, 2008 Diffusion coefficients of drug compounds are crucial parameters used for modeling diffusion. A multicomponent diffusion study on drug-surfactant-water ternary mixtures is reported here

  11. Prescription Drug Reimbursement Form See the back for instructions. Complete all information.

    E-Print Network [OSTI]

    Subramanian, Venkat

    Prescription Drug Reimbursement Form See the back for instructions. Complete all information, and that I (or the patient, if not myself) am eligible for prescription drug benefits. I also certify receipts on the back. Member/Subscriber Information See your prescription drug ID card. C1001 9-12 #12;*C

  12. Annu. Rev. Med. 2002. 53:595614 RATIONAL APPROACH TO AIDS DRUG DESIGN

    E-Print Network [OSTI]

    Annu. Rev. Med. 2002. 53:595614 RATIONAL APPROACH TO AIDS DRUG DESIGN THROUGH STRUCTURAL BIOLOGY than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse

  13. A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users

    E-Print Network [OSTI]

    A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users Vahid (CSMG), The IRMACS Centre Simon Fraser University Background Intravenous drug users (IDU) sharing needles for injecting illicit drugs are highly vulnerable to HIV infection because transmission

  14. CECM Day 2009 IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users

    E-Print Network [OSTI]

    CECM Day 2009 IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users showed, using a risk behaviour-driven, individual-based (cellular automaton) model of injection drug is likely to be unrealistic for many drug treatment programs, where support is provided that may reduce risk

  15. Drug-FreePolicy University of Kentucky 2012-2013 Undergraduate Bulletin 304

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug-FreePolicy University of Kentucky 2012-2013 Undergraduate Bulletin 304 Policy Statement as a Drug-Free Institution TheUniversityofKentuckyiscommittedtoprovidingahealthyandsafe environment for its, dispensation, distribu- tion or manufacture of alcohol or illicit drugs. Conduct which is violative

  16. Evolution of Drug-resistant Viral Populations during Interruption of Antiretroviral Therapy

    E-Print Network [OSTI]

    Ahlers, Guenter

    1 Evolution of Drug-resistant Viral Populations during Interruption of Antiretroviral Therapy Running title: Evolution and fitness of drug-resistant viruses Dongning Wang1 , Charles B. Hicks2 , Neela antiretroviral treatment (ART) interruption allows determination of the evolution of3 drug-resistant viruses

  17. Drug-FreePolicy University of Kentucky 2013-2014 Undergraduate Bulletin 318

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug-FreePolicy University of Kentucky 2013-2014 Undergraduate Bulletin 318 Policy Statement as a Drug-Free Institution TheUniversityofKentuckyiscommittedtoprovidingahealthyandsafe environment for its, dispensation, distribu- tion or manufacture of alcohol or illicit drugs. Conduct which is violative

  18. USC Drug-Free Prevention, education and counseling services along with university

    E-Print Network [OSTI]

    Southern California, University of

    USC Drug-Free Prevention, education and counseling services along with university policies and procedures for preserving a drug-free workplace and study environment A message from President C. L. Max, and other drugs. Academic life can be stressful at times. Students often feel the weight of the goal

  19. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug for drug discovery is the utilization of a biological assay to screen a large library of compounds (>100

  20. A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer and Giovanni De Micheli

    E-Print Network [OSTI]

    De Micheli, Giovanni

    A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer, Switzerland. Email: nicolas.widmer@chuv.ch Abstract--Drug delivery is one of the most common clinical routines-invasive and accurate way. This paper proposes a Drug Administration Decision Support System (DADSS) to help clinicians

  1. Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic context.

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    1 Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic.drugalcdep.2011.09.002 #12;2 Tobacco, alcohol, cannabis and other illegal drug use among young adults (CAST), other illegal drug use. Socioeconomic position was defined by educational attainment

  2. RESEARCH ARTICLE Open Access Treatment for illegal drug use disorders: the role

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    RESEARCH ARTICLE Open Access Treatment for illegal drug use disorders: the role of comorbid mood for illegal drug use disorders. Methods: Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 20012002 and 20042005, n = 34,653). Lifetime DSM-IV illegal drug use

  3. The encapsulation of hydrophobic drugs in Pluronic F127 micelles: the effects of drug hydrophobicity, solution temperature and pH

    E-Print Network [OSTI]

    Rajib Basak; Ranjini Bandyopadhyay

    2014-06-27T23:59:59.000Z

    Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo- Scanning Electron Microscopy and Dynamic Light Scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution. The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules. The hydration of the micellar core at lower temperatures is verified using fluorescence measurements. Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.

  4. Image texture analysis of elastograms

    E-Print Network [OSTI]

    Hussain, Fasahat

    1999-01-01T23:59:59.000Z

    generated elastograms to obtain effective texture features. Four image analysis techniques, co-occurrence statistics, wavelet decomposition, fractal analysis and granulomeay are used to extract a number of features from each image. The inclusions...-RESOLUTION FRACTAL ANALYSIS . . . . . . E. GRANULOMETRIC FEATURES . . F. DATA NORMALIZATION . G. SEPARABILITY MEASURE 13 13 . . . . . 14 . . . . . 20 . . . . . 29 33 36 36 IV TEXTURE ANALYSIS OF SIMULATED ELASTOGRAMS. . . . . . . . . . . 38 A. SIMULATION...

  5. Video surveillance with speckle imaging

    DOE Patents [OSTI]

    Carrano, Carmen J. (Livermore, CA); Brase, James M. (Pleasanton, CA)

    2007-07-17T23:59:59.000Z

    A surveillance system looks through the atmosphere along a horizontal or slant path. Turbulence along the path causes blurring. The blurring is corrected by speckle processing short exposure images recorded with a camera. The exposures are short enough to effectively freeze the atmospheric turbulence. Speckle processing is used to recover a better quality image of the scene.

  6. Image Mining: Detecting Deforestation Patterns

    E-Print Network [OSTI]

    Camara, Gilberto

    54 Chapter IV Image Mining: Detecting Deforestation Patterns Through Satellites Marcelino Pereira to analyze satellite images and extract knowledge from this kind of data. The Amazonia deforestation problem of change on deforested areas of Amazonia. The purpose of the authors is to present relevant technologies

  7. Drug repositioning and indication discovery using description logics

    E-Print Network [OSTI]

    Croset, Samuel

    2014-10-07T23:59:59.000Z

    behind the repurposing. Understanding the logic backing the 21 findings is paramount in order to build successful predictive methods later on. 1.2.1 Sildenafil: repositioning from clinical side-effects The National Health Service (NHS) defines angina as a... breast cancer preventive properties. This drug is an example of smart and continuous development, expanding from one indication to another. The fundamental reasons behind the repositioning are grounded on early-stage experimental evidence and not due to a...

  8. Feeling molecular forces: tactile feedback to enhance drug design

    E-Print Network [OSTI]

    Williams, Jocylin Amber

    2013-02-22T23:59:59.000Z

    Programs 8 Academic Scholarships Texas A8 M University In partial fulfillment of the requirements of the UNIVERSITY UNDERGRADUATE RESEARCH FELLOWS Approved as to style and content by: Edgar F. Meyer' (Fellows-Co-Advisor) Edward A. Funkhouser... Texas A&M University Fellows Advisor: Dr. Edgar F. Meyer Department of Biochemistry and Biophysics Molecular modeling is a vital component for structure-based drug design. Currently implemented technology combines data and graphics to give the user...

  9. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26T23:59:59.000Z

    in optical thickness of the sensor tip. Cortisol was immobilised on the biosensor tip surface by forming an adduct of hydrocortisone 21-hemisuccinate and a pentylamine-biotin linker through an amide bond, then allowing the biotin moiety on this cortisol... adduct to bind to the streptavidin-conjugated biosensor tip. The cortisol- Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents PLOS ONE | DOI:10.1371/journal.pone.0113402 November 26, 2014 4 / 21 conjugated sensors were immersed...

  10. 1Energy Metabolism Laboratory Intelligent Design of the Exercise Drug

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    underlies risk for metabolic disease (e.g. Type-2 Diabetes). #12;5Energy Metabolism Laboratory H H OH OH CH21Energy Metabolism Laboratory H H OH OH CH2OH H OH OH H Intelligent Design of the Exercise Drug;2Energy Metabolism Laboratory H H OH OH CH2OH H OH OH H Lab Mission Statement To understand how physical

  11. Instrumentation for parallel magnetic resonance imaging

    E-Print Network [OSTI]

    Brown, David Gerald

    2007-04-25T23:59:59.000Z

    Parallel magnetic resonance (MR) imaging may be used to increase either the throughput or the speed of the MR imaging experiment. As such, parallel imaging may be accomplished either through a "parallelization" of the MR experiment, or by the use...

  12. Digital holographic imaging of aquatic species

    E-Print Network [OSTI]

    Domnguez-Caballero, Jos Antonio

    2006-01-01T23:59:59.000Z

    The aim of this thesis is to design, develop and implement a digital holographic imaging (DHI) system, capable of capturing three-dimensional (3D) images of aquatic species. The images produced by this system are used in ...

  13. Imaging Oxygen Molecules Up Close | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Imaging Oxygen Molecules Up Close Imaging Oxygen Molecules Up Close Released: March 20, 2011 ARRA-enabled upgrades enhance research capabilities STM images of the same TiO2(110)...

  14. Neutron Imaging of Advanced Engine Technologies

    Broader source: Energy.gov (indexed) [DOE]

    Highly sensitive to water and hydrocarbonsfuel * Can image carbon soot layer due to absorption of water and HC - Image is based on absence of neutrons * X-ray imaging relies upon...

  15. Medical Image Registration: A Quick Win

    E-Print Network [OSTI]

    Ansorge, Richard

    2008-11-11T23:59:59.000Z

    Medical Image Registration A Quick Win Richard Ansorge The problem CT, MRI, PET and Ultrasound produce 3D volume images Typically 256 x 256 x 256 = 16,777,216 image voxels. Combining modalities (inter modality) gives extra information. Repeated... imaging over time same modality, e.g. MRI, (intra modality) equally important. Have to spatially register the images. Example brain lesion CT MRI PET PET-MR Fusion The PET image shows...

  16. Image indexing using color correlograms

    DOE Patents [OSTI]

    Huang, Jing (Ossining, NY); Kumar, Shanmugasundaram Ravi (San Jose, CA); Mitra, Mandar (Calcutta, IN); Zhu, Wei-Jing (Ossining, NY)

    2001-01-01T23:59:59.000Z

    A color correlogram is a three-dimensional table indexed by color and distance between pixels which expresses how the spatial correlation of color changes with distance in a stored image. The color correlogram may be used to distinguish an image from other images in a database. To create a color correlogram, the colors in the image are quantized into m color values, c.sub.i . . . c.sub.m. Also, the distance values k.epsilon.[d] to be used in the correlogram are determined where [d] is the set of distances between pixels in the image, and where dmax is the maximum distance measurement between pixels in the image. Each entry (i, j, k) in the table is the probability of finding a pixel of color c.sub.i at a selected distance k from a pixel of color c.sub.i. A color autocorrelogram, which is a restricted version of the color correlogram that considers color pairs of the form (i,i) only, may also be used to identify an image.

  17. Reaction product imaging

    SciTech Connect (OSTI)

    Chandler, D.W. [Sandia National Laboratories, Livermore, CA (United States)

    1993-12-01T23:59:59.000Z

    Over the past few years the author has investigated the photochemistry of small molecules using the photofragment imaging technique. Bond energies, spectroscopy of radicals, dissociation dynamics and branching ratios are examples of information obtained by this technique. Along with extending the technique to the study of bimolecular reactions, efforts to make the technique as quantitative as possible have been the focus of the research effort. To this end, the author has measured the bond energy of the C-H bond in acetylene, branching ratios in the dissociation of HI, the energetics of CH{sub 3}Br, CD{sub 3}Br, C{sub 2}H{sub 5}Br and C{sub 2}H{sub 5}OBr dissociation, and the alignment of the CD{sub 3} fragment from CD{sub 3}I photolysis. In an effort to extend the technique to bimolecular reactions the author has studied the reaction of H with HI and the isotopic exchange reaction between H and D{sub 2}.

  18. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W. (East Moriches, NY); Brill, A. Bertrand (Shoreham, NY); Bizais, Yves J. C. (Upton, NY); Rowe, R. Wanda (Upton, NY); Zubal, I. George (Upton, NY)

    1986-01-01T23:59:59.000Z

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  19. The ethics of smart drugs: Moral judgments about healthy peoples use of cognitive-enhancing drugs

    E-Print Network [OSTI]

    Scheske, Christel; Schnall, Simone

    2012-01-01T23:59:59.000Z

    of the natural. In A. Eaglesham, S. G. Pueppke, & R. W. Hardy (Eds.), NABC Report 13: Genetically modified food and the consumer (pp. 127140). Ithaca, NY: National Agricultural Biotechnology Council. Sahakian, B., & Morein-Zamir, S. (2007). Professors little... ). Cognition-enhancing drugs. The Milbank Quarterly, 82, 483506. Nuffield Council on Bioethics. (1999). Genetically modified crops: The ethical and social issues. London, England: Author. Petroczi, A., & Aidman, E. (2008). Psychological drivers in doping...

  20. The ethics of smart drugs: Moral judgments about healthy peoples use of cognitive-enhancing drugs

    E-Print Network [OSTI]

    Scheske, Christel; Schnall, Simone

    2012-01-01T23:59:59.000Z

    York: Guilford. Sagoff, M. (2001). Genetic engineering and the concept of the natural. In A. Eaglesham, S. G. Pueppke, & R. W. Hardy (Eds.) NABC Report 13: Genetically Modified Food and the Consumer (pp. 127-140). Ithaca, NY: National Agricultural... survey. Addiction, 99, 96- 106. Mehlman, M. J. (2004). Cognition-enhancing drugs. The Milbank Quarterly, 82, 483-506. Nuffield Council on Bioethics (1999). Genetically modified crops: The ethical and social issues. London: Nuffield Council...

  1. Correlated Biofilm Imaging, Transport and Metabolism Measurements...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biofilm Imaging, Transport and Metabolism Measurements via Combined Nuclear Magnetic Resonance and Confocal Correlated Biofilm Imaging, Transport and Metabolism Measurements via...

  2. Flow Imaging Using MRI: Quantification and Analysis

    E-Print Network [OSTI]

    Jiraraksopakun, Yuttapong

    2010-07-14T23:59:59.000Z

    dynamics (CFD) and the conventional optimal flow imaging based on particle image velocimetry (PIV). The results demonstrated the improvement from the quantification using solely the conventional HARP method....

  3. Nanometer Resolution Imaging by SIngle Molecule Switching. |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanometer Resolution Imaging by SIngle Molecule Switching. Nanometer Resolution Imaging by SIngle Molecule Switching. Abstract: The fluorescence intensity of single molecules can...

  4. ORNL microscopy directly images problematic lithium dendrites...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    865.574.7308 ORNL microscopy directly images problematic lithium dendrites in batteries ORNL electron microscopy captured the first real-time nanoscale images of the nucleation and...

  5. Formation of drug-bearing vesicles in mixed colloids of bile salts and phosphatidylcholine

    SciTech Connect (OSTI)

    Hjelm, R.P.; Mang, J. [Los Alamos National Lab., NM (United States); Hofmann, A.F.; Schteingart, C. [Univ. of California, San Diego, CA (United States); Alkan-Onyuksel, H.; Ayd, S. [Univ. of Illinois, Urbana, IL (United States)

    1997-11-01T23:59:59.000Z

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors used small-angle neutron scattering to study drug interactions with mixed colloids of bile salt and phosphatidylcholine. Because the mixed colloids form liposomes spontaneously, this system is a model for drug-bile interactions that are important in understanding the efficacy of oral drug formulations and in advanced applications for liposome drug delivery systems. The authors studied particle formation in incorporation of enzymatic products formed in the gut and the effects of cholesteric drugs and taxol on vesicle formation. The studies show that particle morphology is not affected by inclusion of most cholesteric drugs and taxol, and is not affected by incorporation of the products of enzymatic action. The findings suggest that particle form is important for the physiological function of bile and they are beginning to show which drugs affect liposome formation.

  6. Image Storage in Hot Vapors

    E-Print Network [OSTI]

    L. Zhao; T. Wang; Y. Xiao; S. F. Yelin

    2007-10-22T23:59:59.000Z

    We theoretically investigate image propagation and storage in hot atomic vapor. A $4f$ system is adopted for imaging and an atomic vapor cell is placed over the transform plane. The Fraunhofer diffraction pattern of an object in the object plane can thus be transformed into atomic Raman coherence according to the idea of ``light storage''. We investigate how the stored diffraction pattern evolves under diffusion. Our result indicates, under appropriate conditions, that an image can be reconstructed with high fidelity. The main reason for this procedure to work is the fact that diffusion of opposite-phase components of the diffraction pattern interfere destructively.

  7. Quantum ghost imaging through turbulence

    E-Print Network [OSTI]

    Dixon, P. Ben

    We investigate the effect of turbulence on quantum ghost imaging. We use entangled photons and demonstrate that for a specific experimental configuration the effect of turbulence can be greatly diminished. By decoupling ...

  8. Scanning strategies for imaging arrays

    E-Print Network [OSTI]

    A. Kovacs

    2008-06-30T23:59:59.000Z

    Large-format (sub)millimeter wavelength imaging arrays are best operated in scanning observing modes rather than traditional position-switched (chopped) modes. The choice of observing mode is critical for isolating source signals from various types of noise interference, especially for ground-based instrumentation operating under a bright atmosphere. Ideal observing strategies can combat 1/f noise, resist instrumental defects, sensitively recover emission on large scales, and provide an even field coverage -- all under feasible requirements of telescope movement. This work aims to guide the design of observing patterns that maximize scientific returns. It also compares some of the popular choices of observing modes for (sub)millimeter imaging, such as random, Lissajous, billiard, spiral, On-The-Fly (OTF), DREAM, chopped and stare patterns. Many of the conclusions are also applicable other imaging applications and imaging in one dimension (e.g. spectroscopic observations).

  9. Imaging atoms in 3-D

    ScienceCinema (OSTI)

    Ercius, Peter

    2014-06-27T23:59:59.000Z

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  10. Motion Estimation from Disparity Images

    E-Print Network [OSTI]

    Demirdjian, D.

    2001-05-07T23:59:59.000Z

    A new method for 3D rigid motion estimation from stereo is proposed in this paper. The appealing feature of this method is that it directly uses the disparity images obtained from stereo matching. We assume that the stereo ...

  11. VAX-based ''IMAGE'' backup

    SciTech Connect (OSTI)

    Harris, D.D.

    1985-10-01T23:59:59.000Z

    Increasing usage of the Applicon IMAGE systems at Bendix Kansas City Division (BKC) conflicts with the need to do daily backup of changed AGS files. This paper describes a VAX-based method for automated, unattended, off-shift backup.

  12. Imaging atoms in 3-D

    SciTech Connect (OSTI)

    Ercius, Peter

    2013-10-31T23:59:59.000Z

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  13. Imaging Liquids Using Microfluidic Cells

    SciTech Connect (OSTI)

    Yu, Xiao-Ying; Liu, Bingwen; Yang, Li

    2013-05-10T23:59:59.000Z

    Chemistry occurring in the liquid and liquid surface is important in many applications. Chemical imaging of liquids using vacuum based analytical techniques is challenging due to the difficulty in working with liquids with high volatility. Recent development in microfluidics enabled and increased our capabilities to study liquid in situ using surface sensitive techniques such as electron microscopy and spectroscopy. Due to its small size, low cost, and flexibility in design, liquid cells based on microfluidics have been increasingly used in studying and imaging complex phenomena involving liquids. This paper presents a review of microfluidic cells that were developed to adapt to electron microscopes and various spectrometers for in situ chemical analysis and imaging of liquids. The following topics will be covered including cell designs, fabrication techniques, unique technical features for vacuum compatible cells, and imaging with electron microscopy and spectroscopy. Challenges are summarized and recommendations for future development priority are proposed.

  14. Thomas Jefferson: image and ideology

    E-Print Network [OSTI]

    Wilson, Gaye N. S. B.

    2012-11-30T23:59:59.000Z

    This thesis explores the public image of Thomas Jefferson as recorded in his major life portraits. It consults the traditions that surrounded eighteenth-century portraiture and the history of the portrait as a means of ...

  15. Identifying structural damage from images

    E-Print Network [OSTI]

    Chen, ZhiQiang

    2009-01-01T23:59:59.000Z

    Pattern Recognition, 26 PDC. Paci?c disater center, 2008.which were acquired from the Paci?c Disaster Center (PDC) (PDC, 2008). These images cover Banda Aceh and its

  16. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, M.A.; Tsang, B.W.

    1994-06-28T23:59:59.000Z

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

  17. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, Mark A. (West Lafayette, IN); Tsang, Brenda W. (Lafayette, IN)

    1994-01-01T23:59:59.000Z

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.

  18. DOI: 10.1002/adfm.200800406 In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated

    E-Print Network [OSTI]

    Papautsky, Ian

    of Pharmacy University of Cincinnati Cincinnati, OH 45221 (USA) Prof. J. Lian Department of Mechanical, Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy, NY 12180 (USA) Prof. L. Wang, Prof. R. C. Ewing Departments of Geological Sciences, Nuclear Engineering & Radiological Sciences

  19. PET imaging predicts future body weight and cocaine preference

    SciTech Connect (OSTI)

    Michaelides M.; Wang G.; Michaelides M.; Thanos P.K. Kim R.; Cho J.; Ananth M.; Wang G.-J.; Volkow N.D.

    2011-08-28T23:59:59.000Z

    Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventral and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans.

  20. Predicting drug metabolism: experiment and/or computation?

    E-Print Network [OSTI]

    Kirchmair, Johannes; Gller, Andreas H.; Lang, Dieter; Kunze, Jens; Testa, Bernard; Wilson, Ian D.; Glen, Robert C.; Schneider, Gisbert

    2015-04-24T23:59:59.000Z

    such as hepatic microsomes will continue to provide a solid bedrock for metabolite generation the development of so-called 3D bioreactor (organ on a chip) technology is a rapidly developing field. These systems provide a much more organ-like environment... for cells, which can be maintained for long periods whilst being exposed to drugs in order to assess metabolism and toxicity100-102. If, as seems likely, such bioreactors (which are not limited to hepatocytes) can be made into a robust and easily deployed...

  1. Drug-resistant TB Nature-inspired Polymers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField Campaign:INEA : Papers69ChristopherDrug-resistant TB Nature-inspired

  2. Image description. Cover Image End of image description. NATIONAL CENTER FOR EDUCATION STATISTICS

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    a context for examining the data they submitted to IPEDS. Our goal is to produce a report that is useful University 2 #12;Image description. Bar chart with 10 groups with 2 items per group.Y scale titled Percent

  3. BLIND DECONVOLUTION AND DEBLURRING IN IMAGE ANALYSIS

    E-Print Network [OSTI]

    Qiu, Peihua

    BLIND DECONVOLUTION AND DEBLURRING IN IMAGE ANALYSIS Peter Hall 1 and Peihua Qiu 1.2 ABSTRACT. Blind deconvolution problems arise in image analysis when both the extent of image blur, and the true from image data. This is a blind deconvolution problem and is, of course, significantly more

  4. Image Based Gisting in CLIR Mark Sanderson

    E-Print Network [OSTI]

    Sanderson, Mark

    from the Rosch [1] paper. These search terms were entered into the Google Image search engine in order the ability of subjects to derive the search term that might have been used to return a set of images from on subjects' abilities in this respect. Search terms were defined and images found using an online image

  5. Image Fusion: Principles, Methods, and Applications

    E-Print Network [OSTI]

    Sroubek, Filip

    different sensors (visible and infrared, CT and NMR, or panchromatic and multispectral satellite images fusion is used to achieve high spatial and spectral resolutions by combining images from two sensors, one applications have appeared in medical imaging like simultaneous evaluation of CT, MRI, and/or PET images

  6. Automatic Eyeglasses Removal from Face Images

    E-Print Network [OSTI]

    Narasayya, Vivek

    Automatic Eyeglasses Removal from Face Images Chenyu Wu, Ce Liu, Heung-Yueng Shum, Member, IEEE an intelligent image editing and face synthesis system that automatically removes eyeglasses from an input frontal face image. Although conventional image editing tools can be used to remove eyeglasses by pixel

  7. Image processing applications in NDE

    SciTech Connect (OSTI)

    Morris, R.A.

    1980-01-01T23:59:59.000Z

    Nondestructive examination (NDE) can be defined as a technique or collection of techniques that permits one to determine some property of a material or object without damaging the object. There are a large number of such techniques and most of them use visual imaging in one form or another. They vary from holographic interferometry where displacements under stress are measured to the visual inspection of an objects surface to detect cracks after penetrant has been applied. The use of image processing techniques on the images produced by NDE is relatively new and can be divided into three general categories: classical image enhancement; mensuration techniques; and quantitative sensitometry. An example is discussed of how image processing techniques are used to nondestructively and destructively test the product throughout its life cycle. The product that will be followed is the microballoon target used in the laser fusion program. The laser target is a small (50 to 100 ..mu..m - dia) glass sphere with typical wall thickness of 0.5 to 6 ..mu..m. The sphere may be used as is or may be given a number of coatings of any number of materials. The beads are mass produced by the millions and the first nondestructive test is to separate the obviously bad beads (broken or incomplete) from the good ones. After this has been done, the good beads must be inspected for spherocity and wall thickness uniformity. The microradiography of the glass, uncoated bead is performed on a specially designed low-energy x-ray machine. The beads are mounted in a special jig and placed on a Kodak high resolution plate in a vacuum chamber that contains the x-ray source. The x-ray image is made with an energy less that 2 keV and the resulting images are then inspected at a magnification of 500 to 1000X. Some typical results are presented.

  8. Microscopy image segmentation tool: Robust image data analysis

    SciTech Connect (OSTI)

    Valmianski, Ilya, E-mail: ivalmian@ucsd.edu; Monton, Carlos; Schuller, Ivan K. [Department of Physics and Center for Advanced Nanoscience, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States)] [Department of Physics and Center for Advanced Nanoscience, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States)

    2014-03-15T23:59:59.000Z

    We present a software package called Microscopy Image Segmentation Tool (MIST). MIST is designed for analysis of microscopy images which contain large collections of small regions of interest (ROIs). Originally developed for analysis of porous anodic alumina scanning electron images, MIST capabilities have been expanded to allow use in a large variety of problems including analysis of biological tissue, inorganic and organic film grain structure, as well as nano- and meso-scopic structures. MIST provides a robust segmentation algorithm for the ROIs, includes many useful analysis capabilities, and is highly flexible allowing incorporation of specialized user developed analysis. We describe the unique advantages MIST has over existing analysis software. In addition, we present a number of diverse applications to scanning electron microscopy, atomic force microscopy, magnetic force microscopy, scanning tunneling microscopy, and fluorescent confocal laser scanning microscopy.

  9. STAR Images: Image gallery from the Solenoidal Tracker at RHIC

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The primary physics task of STAR is to study the formation and characteristics of the quark-gluon plasma (QGP), a state of matter believed to exist at sufficiently high energy densities. STAR consists of several types of detectors, each specializing in detecting certain types of particles or characterizing their motion. These detectors allow final statements to be made about the collision. The gallery of STAR images makes available a small collection of event-generated images from Gold-Beam experiments, a simulation of TCP Drift, and a library of STAR instrument and construction photos.

  10. Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery

    E-Print Network [OSTI]

    Stavropoulos, Kathy

    2011-08-31T23:59:59.000Z

    within the lipid monolayer to form a polyethylene glycol (PEG) corona [27]. The polymeric core affects drug encapsulation and release. Drug release from the nanoparticles begins with diffusion processes, followed by erosion, then swelling of the matrix... for preventing water-soluble drugs from leaking out of the core [29]. The corona affects biodistribution and circulation half-life. The PEG corona provides electrostatic and steric stabilization as well as a protective layer from adsorptive recognition proteins...

  11. A client management system for criminal justice referrals to drug abuse treatment

    E-Print Network [OSTI]

    Pate, Wayland Gordon

    1986-01-01T23:59:59.000Z

    over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...A CLIENT MANAGEMENT SYSTEM FOR CRIMINAL JUSTICE REFERRALS TO DRUG ABUSE TREATMENT A Thesis by WAYLAND GORDON PATE Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirements for the degree of MASTER...

  12. anti-hiv drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  13. anti-parkinsonian drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  14. antiparkinsonian drug-induced sleepiness: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lpez-ortega; M Carmen Lpez-vega; M Isabel Lucena; Clinical Pharmacology Service; Virgen De La 35 Drug-induced pruritic micropapular eruption: anastrozole, a commonly used...

  15. Reporting Prescription Drugs, Over-the-Counter Medications, and Dietary Supplements

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2008-02-01T23:59:59.000Z

    Overview of types of prescription drugs and over-the-counter medications that must be reported in DOE's Human Reliability Program.

  16. TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

    E-Print Network [OSTI]

    Chen, Yu-Chian

    Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional ...

  17. Direct encapsulation of water-soluble drug into silica microcapsules for sustained release applications

    SciTech Connect (OSTI)

    Wang Jiexin; Wang Zhihui [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Chen Jianfeng [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: chenjf@mail.buct.edu.cn; Yun, Jimmy [Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent 03-03, Singapore 139959 (Singapore)

    2008-12-01T23:59:59.000Z

    Direct encapsulation of water-soluble drug into silica microcapsules was facilely achieved by a sol-gel process of tetraethoxysilane (TEOS) in W/O emulsion with hydrochloric acid (HCl) aqueous solution containing Tween 80 and drug as well as cyclohexane solution containing Span 80. Two water-soluble drugs of gentamicin sulphate (GS) and salbutamol sulphate (SS) were chosen as model drugs. The characterization of drug encapsulated silica microcapsules by scanning electronic microscopy (SEM), FTIR, thermogravimetry (TG) and N{sub 2} adsorption-desorption analyses indicated that drug was successfully entrapped into silica microcapsules. The as-prepared silica microcapsules were uniform spherical particles with hollow structure, good dispersion and a size of 5-10 {mu}m, and had a specific surface area of about 306 m{sup 2}/g. UV-vis and thermogravimetry (TG) analyses were performed to determine the amount of drug encapsulated in the microcapsules. The BJH pore size distribution (PSD) of silica microcapsules before and after removing drug was examined. In vitro release behavior of drug in simulated body fluid (SBF) revealed that such system exhibited excellent sustained release properties.

  18. Modeling Multiple Drugs on Lung Cancer and Normal Cells using Regression

    E-Print Network [OSTI]

    Chen, Michelle

    2013-01-01T23:59:59.000Z

    of drug combi- nations and factorial design when building awith a 27-run factorial design performs remarkably well forwith a specific factorial design which improves resolution

  19. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, Jr., David N. (Knoxville, TN); Simpson, Marc L. (Knoxville, TN)

    1997-01-01T23:59:59.000Z

    A miniature lens system that corrects for imaging and chromatic aberrations, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components.

  20. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, D.N. Jr.; Simpson, M.L.

    1997-10-21T23:59:59.000Z

    A miniature lens system that corrects for imaging and chromatic aberrations is disclosed, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components. 2 figs.

  1. Adverse Drug Reaction Monitoring In Psychiatric OPD Adverse Drug Reaction Monitoring In Psychiatric Outpatient Department Of A Tertiary Care Hospital

    E-Print Network [OSTI]

    Hiren K. Prajapati; Nisarg D. Joshi; Hiren R. Trivedi; Manubhai C. Parmar; Shilpa P. Jadav; Dinesh M. Parmar; Jalpan G. Kareliya

    Abstracts Background:Pharmacovigilance in psychiatry units can play vital role in detecting adverse drug reactions (ADRs) and alerting physician to such events, thereby protecting the user population from avoidable harm. Objective: To assess the suspected ADRs profile of psychotropic drugs in psychiatry OPD of a tertiary care hospital and its comparison with available literature data as well as to create awareness among the consultant psychiatrists to these ADRs profile. Materials and Methods: A prospective study was conducted in the psychiatry OPD. Thirty five consecutive patients per day were screened irrespective of their psychiatric diagnosis for suspected ADRs on 3 fixed days in a week from January 2011 to December 2011. CDSCO form was used to record the ADRs. Causality was assessed by WHO causality assessment scale while severity was assessed using Hartwig and Siegel scale. Results: Out of 4410 patients were screened, 383 patients were suspected of having at least one ADR. Thus, 8.68 % of our study population reported ADRs. Of 407 events recorded, 369(90.60%) were probable and rest possible according to WHO-UMC causality assessment

  2. Tunable Imaging Filters in Astronomy

    E-Print Network [OSTI]

    J. Bland-Hawthorn

    2000-06-05T23:59:59.000Z

    While tunable filters are a recent development in night time astronomy, they have long been used in other physical sciences, e.g. solar physics, remote sensing and underwater communications. With their ability to tune precisely to a given wavelength using a bandpass optimized for the experiment, tunable filters are already producing some of the deepest narrowband images to date of astrophysical sources. Furthermore, some classes of tunable filters can be used in fast telescope beams and therefore allow for narrowband imaging over angular fields of more than a degree over the sky.

  3. Electronic imaging system and technique

    DOE Patents [OSTI]

    Bolstad, J.O.

    1984-06-12T23:59:59.000Z

    A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

  4. Multispectral imaging method and apparatus

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Vargo, T.D.; Lockhart, R.R.; Descour, M.R.; Richards-Kortum, R.

    1999-07-06T23:59:59.000Z

    A multispectral imaging method and apparatus are described which are adapted for use in determining material properties, especially properties characteristic of abnormal non-dermal cells. A target is illuminated with a narrow band light beam. The target expresses light in response to the excitation. The expressed light is collected and the target's response at specific response wavelengths to specific excitation wavelengths is measured. From the measured multispectral response the target's properties can be determined. A sealed, remote probe and robust components can be used for cervical imaging. 5 figs.

  5. Buried object detection in GPR images

    DOE Patents [OSTI]

    Paglieroni, David W; Chambers, David H; Bond, Steven W; Beer, W. Reginald

    2014-04-29T23:59:59.000Z

    A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

  6. Multi-channel medical imaging system

    DOE Patents [OSTI]

    Frangioni, John V

    2013-12-31T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  7. Chapter 20. Magnetic Resonance Imaging Magnetic Resonance Imaging

    E-Print Network [OSTI]

    , and software training from Siemens Medical Solutions; research funding through the Siemens-MIT Alliance and Technology (HST). 2 Siemens Medical Solutions, Erlangen, Germany. #12;Chapter 20. Magnetic Resonance Imaging, Siemens Medical Solutions, Siemens-MIT Alliance, HST Martinos Catalyst Fund. Project Staff: Audrey P. Fan

  8. Upright cone beam CT imaging using the onboard imager

    SciTech Connect (OSTI)

    Fave, Xenia, E-mail: xjfave@mdanderson.org; Martin, Rachael [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)] [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Yang, Jinzhong; Balter, Peter; Court, Laurence [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Carvalho, Luis [Varian Medical Systems, Zug 6303 (Switzerland)] [Varian Medical Systems, Zug 6303 (Switzerland); Pan, Tinsu [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2014-06-15T23:59:59.000Z

    Purpose: Many patients could benefit from being treated in an upright position. The objectives of this study were to determine whether cone beam computed tomography (CBCT) could be used to acquire upright images for treatment planning and to demonstrate whether reconstruction of upright images maintained accurate geometry and Hounsfield units (HUs). Methods: A TrueBeam linac was programmed in developer mode to take upright CBCT images. The gantry head was positioned at 0, and the couch was rotated to 270. The x-ray source and detector arms were extended to their lateral positions. The x-ray source and gantry remained stationary as fluoroscopic projections were taken and the couch was rotated from 270 to 90. The x-ray tube current was normalized to deposit the same dose (measured using a calibrated Farmer ion chamber) as that received during a clinical helical CT scan to the center of a cylindrical, polyethylene phantom. To extend the field of view, two couch rotation scans were taken with the detector offset 15 cm superiorly and then 15 cm inferiorly. The images from these two scans were stitched together before reconstruction. Upright reconstructions were compared to reconstructions from simulation CT scans of the same phantoms. Two methods were investigated for correcting the HUs, including direct calibration and mapping the values from a simulation CT. Results: Overall geometry, spatial linearity, and high contrast resolution were maintained in upright reconstructions. Some artifacts were created and HU accuracy was compromised; however, these limitations could be removed by mapping the HUs from a simulation CT to the upright reconstruction for treatment planning. Conclusions: The feasibility of using the TrueBeam linac to take upright CBCT images was demonstrated. This technique is straightforward to implement and could be of enormous benefit to patients with thoracic tumors or those who find a supine position difficult to endure.

  9. Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery

    E-Print Network [OSTI]

    Vukmirovic, Neda

    2007-01-01T23:59:59.000Z

    Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

  10. Hadamard multimode optical imaging transceiver

    DOE Patents [OSTI]

    Cooke, Bradly J; Guenther, David C; Tiee, Joe J; Kellum, Mervyn J; Olivas, Nicholas L; Weisse-Bernstein, Nina R; Judd, Stephen L; Braun, Thomas R

    2012-10-30T23:59:59.000Z

    Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture.

  11. Quantum Computing, Metrology, and Imaging

    E-Print Network [OSTI]

    Hwang Lee; Pavel Lougovski; Jonathan P. Dowling

    2005-06-17T23:59:59.000Z

    Information science is entering into a new era in which certain subtleties of quantum mechanics enables large enhancements in computational efficiency and communication security. Naturally, precise control of quantum systems required for the implementation of quantum information processing protocols implies potential breakthoughs in other sciences and technologies. We discuss recent developments in quantum control in optical systems and their applications in metrology and imaging.

  12. Covered Product Category: Imaging Equipment

    Broader source: Energy.gov [DOE]

    FEMP provides acquisition guidance and Federal efficiency requirements across a variety of product categories, including imaging equipment, which is covered by the ENERGY STAR program. Federal laws and requirements mandate that agencies meet these efficiency requirements in all procurement and acquisition actions that are not specifically exempted by law.

  13. Image Compression by Back Propagation

    E-Print Network [OSTI]

    Cottrell, Garrison W.

    CHAPTER 9 Image Compression by Back Propagation: An Example of Extensional Programming* GARRISON W the case with the computatiolls associated with basic cognitive pro- cesses such as vision and audition techniques. The technique we employ is known as back propagation. developed by l1umelhart, Hinton

  14. Image Processing Apr. 16, 2012

    E-Print Network [OSTI]

    Erdem, Erkut

    - The Discrete Fourier transform Log power spectrum #12;Review - The Convolution Theorem The Fourier frequency components Fourier (1807): Periodic functions could be represented as a weighted sum of sines and cosines Image courtesy of Technology Review #12;Review - Fourier Transform We want

  15. Enlarge Image Peer pressure. Magnetic

    E-Print Network [OSTI]

    Thywissen, Joseph

    to stick it to your refrigerator, but an ultra-cold gas magnetizes itself just as do metals such as ironEnlarge Image Peer pressure. Magnetic domains in steel (vertical bans) arise when neighboring electrons point their magnetic poles in the same direction. CREDIT: ZUREKS, CHRIS VARDON

  16. Enlarge Image Peer pressure. Magnetic

    E-Print Network [OSTI]

    Enlarge Image Peer pressure. Magnetic domains in steel (vertical bans) arise when neighboring electrons point their magnetic poles in the same direction. CREDIT: ZUREKS, CHRIS VARDON/WIKIMEDIA By Adrian Cho ScienceNOW Daily News 18 September 2009 It would be tough to stick it to your refrigerator

  17. Medical Imaging Computed Tomography (CT)

    E-Print Network [OSTI]

    Massey, Thomas N.

    Module 10 Medical Imaging X-rays Computed Tomography (CT) Positron Emission Tomography (PET Sources PET-TOF #12;Four Sources PET #12;Four Sources PET-TOF #12;PET Scan MRI CT scan #12;Endocrine Gland,000 pixels! #12;Modern Example of CT Scan with the addition of Surface Shading Standard CT With Surface

  18. Dissertation Imaging as Characterization Techniques

    E-Print Network [OSTI]

    Sites, James R.

    Telluride Photovoltaics The goal of increasing the efficiency of solar cell devices is a universal oneDissertation Imaging as Characterization Techniques for Thin-Film Cadmium Telluride Photovoltaics. Increased photovoltaic (PV) performance means an increase in competition with other energy tech- nologies

  19. Low field magnetic resonance imaging

    DOE Patents [OSTI]

    Pines, Alexander (Berkeley, CA); Sakellariou, Dimitrios (Billancourt, FR); Meriles, Carlos A. (Fort Lee, NJ); Trabesinger, Andreas H. (London, GB)

    2010-07-13T23:59:59.000Z

    A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.

  20. Non-Destructive Neutron Imaging to Analyze Particulate Filters...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Neutron Imaging to Analyze Particulate Filters Non-Destructive Neutron Imaging to Analyze Particulate Filters Non-destructive, non-invasive imaging is being employed in the...