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Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Wednesday, 24 February 2010 00:00 Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

2

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

3

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

4

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

5

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

6

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography Print Humankind has benefitted from a long and productive relationship with yeast. For example, fermentation by yeast is an essential step in the production of bread, beer, wine, and even biofuels. However, not all yeast are beneficial. One strain of yeast, Candida albicans, grows unnoticed on most peoples' skin and in the intestines. In response to certain environmental conditions, C. albicans can switch to a pathogenic phenotype that causes infection. Yeast infections are commonplace, and in otherwise healthy individuals are usually treatable with over-the-counter medications; however, individuals with weakened immune systems can have very serious systemic consequences from a yeast infection. Treating systemic yeast infections is becoming increasingly difficult due to the growing number of yeast strains that have developed resistance to existing antimicrobial drugs. Consequently, there is a pressing need to develop new types of drugs capable of circumventing yeast drug-resistance mechanisms. To this end Stanford, University of California, San Francisco and LBNL researchers have used soft x-ray tomography to image the 3-D structure of both benign and infectious C. albicans yeast. They then imaged this yeast when treated with peptoids, a class of molecules that mimic the peptides our immune system uses as the first line of defense against microbial attack. Unlike conventional antimicrobials, microbes have yet to develop resistance mechanisms against peptides or peptoids, making them appealing candidates for pharmaceutical development.

7

Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based Assay Demonstrates Antibacterial Activity of Croconazole against Mycobacterium ulcerans  

Science Journals Connector (OSTI)

...Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based...commonly available, but registered agrochemicals have also been broadly examined for...fungicides, commercialized as drugs or agrochemicals. These compounds are cytochrome P450...

Nicole Scherr; Katharina Röltgen; Matthias Witschel; Gerd Pluschke

2012-09-24T23:59:59.000Z

8

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis  

Science Journals Connector (OSTI)

Utilizing a chemical genomics-based screening platform referred to as the Candida albicans fitness test (CaFT), we have identified novel inhibitors of Gwt1 and a second enzyme in the glycosylphosphatidylinositol (GPI) cell wall anchor pathway, Mcd4. ... The response of each heterozygote to the effects of the compound is then appraised by calculating a normalized Z score, with a positive value indicating hypersensitivity and a negative value reflecting resistance (or hyposensitivity) to the tested compound. ... MCD4 heterozygote hypersensitivity to M743 is directly demonstrated by serial dilution spot tests on drug-containing plates (Figure S2) and further corroborated by genetic knockdown of MCD4 expression using a conditional mutant under the control of a tetracycline-regulatable promoter (Figure S4). ...

Paul A. Mann; Catherine A. McLellan; Sandra Koseoglu; Qian Si; Elena Kuzmin; Amy Flattery; Guy Harris; Xinwei Sher; Nicholas Murgolo; Hao Wang; Kristine Devito; Nuria de Pedro; Olga Genilloud; Jennifer Nielsen Kahn; Bo Jiang; Michael Costanzo; Charlie Boone; Charles G. Garlisi; Susan Lindquist; Terry Roemer

2014-12-05T23:59:59.000Z

9

Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids  

E-Print Network [OSTI]

Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids that circumvent fungal drug- resistance mechanisms. In this work we used soft X-ray tomogra- phy to image of an entire, fully functional biological system, i.e., in the milieu of a cell (8, 10). Recently, soft X-ray

Barron, Annelise E.

10

PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.  

SciTech Connect (OSTI)

There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain. This will be followed by highlights of PET studies of the acute effects of the psychostimulant drugs cocaine and methylphenidate (ritalin) and studies of the chronic effects of cocaine and of tobacco smoke on the human brain. This chapter concludes with the description of a study which uses brain imaging coupled with a specific pharmacological challenge to address the age-old question of why some people who experiment with drugs become addicted while others do not.

Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

2001-01-29T23:59:59.000Z

11

Imaging Antifungal Drug Molecules in Action using Soft X-Ray...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a cell. This use of soft x-ray tomography is now generating considerable interest in the pharmaceutical industry as a potential method for reducing the cost and time it takes to...

12

Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.  

E-Print Network [OSTI]

?? The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Tsao, Ning

2013-01-01T23:59:59.000Z

13

Optical imaging for the new grammar of drug discovery  

Science Journals Connector (OSTI)

...enabling optical imaging platform will combine optical...validating highly specific chemical and biological tools...are generated through chemical reactions and therefore...enabling optical imaging platform will combine optical...validating highly specific chemical and biological tools...

2011-01-01T23:59:59.000Z

14

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv Kumar*, Apurva Kulkarni, Dattatri K Nagesha, Srinivas Sridhar  

E-Print Network [OSTI]

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv decade engineered nanoplatforms have seen a momentous progress in developing a multimodal theranostic and application of theranostic phospholipid based polymeric micelles for optical fluorescence imaging

Sridhar, Srinivas

15

Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging  

Science Journals Connector (OSTI)

Abstract Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core–shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic \\{NPs\\} (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mm?1 s?1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic \\{NPs\\} with Gd-conjugation and Dox doping.

Lin-Chen Ho; Chao-Hsiung Hsu; Chung-Mao Ou; Chia-Wei Wang; Tsang-Pai Liu; Lian-Pin Hwang; Yung-Ya Lin; Huan-Tsung Chang

2015-01-01T23:59:59.000Z

16

Novel Polysaccharide Based Polymers and Nanoparticles for Controlled Drug Delivery and Biomedical Imaging.  

E-Print Network [OSTI]

??The use of polysaccharides as building blocks in the development of drugs and contrast agents delivery systems is rapidly growing. This can be attributed to… (more)

Shalviri, Alireza

2013-01-01T23:59:59.000Z

17

Laser postionization secondary neutral mass spectrometry in tissue: a powerful tool for elemental and molecular imaging in the development of targeted drugs  

Science Journals Connector (OSTI)

...32 Chandra S, Lorey DRI, Smith DR. Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered by two combined BNCT drugs: in vitro studies on human glioblastoma...

Andrea Wittig; Heinrich F. Arlinghaus; Christian Kriegeskotte; Raymond L. Moss; Klaas Appelman; Kurt W. Schmid; Wolfgang A.G. Sauerwein

2008-07-01T23:59:59.000Z

18

E-Print Network 3.0 - antifungal compound produced Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

requirements to produce the antifungal response and can provide a guide for the design of compounds... with this biological activity. Antifungal activity of these compounds...

19

E-Print Network 3.0 - antifungal activity evaluation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

used. The antifungal... AccessResearch article Candidaemia and antifungal therapy in a French University Hospital: rough trends... the management of at risk patients as well as...

20

Applications of single molecule and nanoparticle imaging in chemical separation, photocatalysis, and drug delivery.  

E-Print Network [OSTI]

??This dissertation includes five chapters. Chapter 1 introduces single molecule and nanoparticle imaging techniques and their applications. Chapter 2 is a study of electrophoretic migration… (more)

Han, Rui

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells  

Science Journals Connector (OSTI)

...high-throughput studies using the SP technique. On the other hand, recently, automated image analysis aided by high-performance computing has enabled rapid advances in the development of high-throughput image-based assays (19-22). Considering...

Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T.C. Wong

2010-10-01T23:59:59.000Z

22

Multidrug-Resistant Transporter Mdr1p-Mediated Uptake of a Novel Antifungal Compound  

Science Journals Connector (OSTI)

...Unfortunately, the antifungal pipeline has slowed down considerably...supplemental material) in the wax moth Galleria mellonella infection...exacerbated by the shrinking pipeline of antimicrobial agents. Extensive...insight into the antifungal pipeline: selected new molecules and...

Nuo Sun; Dongmei Li; William Fonzi; Xin Li; Lixin Zhang; Richard Calderone

2013-09-16T23:59:59.000Z

23

Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases  

Science Journals Connector (OSTI)

Theranostic nanoparticles with both therapeutic and imaging abilities have the promise to revolutionize diagnosis, therapy, and prognosis. Early and accurate detection along with swift treatment are the most i...

M. Howell; C. Wang; A. Mahmoud; G. Hellermann…

2013-08-01T23:59:59.000Z

24

E-Print Network 3.0 - antibiotics antifungal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(Foot) Antiparasitic treatments Antiseptics & wound cleansers Anti... Contraceptives Cough, cold & flu Denture pain relief Digestive aids Ear care Eye care Feminine antifungal &...

25

E-Print Network 3.0 - antifungal pharmacophore sites Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

antifungal pharmacophore sites Page: << < 1 2 3 4 5 > >> 1 Pharmacophore modeling and 3D-QSAR of novel chalcone derivatives as Plasmodium falciparum growth inhibitors Summary:...

26

E-Print Network 3.0 - antifungal polygalacturonase-inhibiting...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Sample search results for: antifungal polygalacturonase-inhibiting protein Page: << < 1 2 3 4 5 > >> 1 Plant Molecular Biology 53: 357369, 2003. 2003 Kluwer Academic...

27

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Lensless Imaging of Whole Biological Cells with Soft X-Rays Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Wednesday, 26 May 2010 00:00 A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

28

Prescription Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

29

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

30

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

31

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

32

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

33

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

34

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

35

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

36

Lensless Imaging of Whole Biological Cells with Soft X-Rays  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Whole Biological Cells with Soft X-Rays Print Lensless Imaging of Whole Biological Cells with Soft X-Rays Print A team of scientists has used x-ray diffraction microscopy at ALS Beamline 9.0.1 to make images of whole yeast cells, achieving the highest resolution-11 to 13 nanometers (billionths of a meter)-ever obtained with this method for biological specimens. Their success indicates that full 3-D tomography of whole cells at equivalent resolution should soon be possible. The National Center for X-Ray Tomography at ALS Beamline 2.1 images whole, frozen hydrated cells in 3-D (see highlight "Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography"). Large numbers of cells can currently be processed in a short time at resolutions of 40 to 60 nanometers, but the ability to increase resolution to the 10-nanometer range would enhance research capabilities in both biology and materials sciences.

37

Imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Print Imaging Print The wavelengths of soft x-ray photons (1-15 nm) are very well matched to the creation of "nanoscopes" capable of probing the interior structure of biological cells and inorganic mesoscopic systems.Topics addressed by soft x-ray imaging techniques include cell biology, nanomagnetism, environmental science, and polymers. The tunability of synchrotron radiation is absolutely essential for the creation of contrast mechanisms. Cell biology CAT scans are performed in the "water window" (300-500 eV). Nanomagnetism studies require the energy range characteristic of iron, cobalt, and nickel (600-900 eV). Mid- and far-infrared (energies below 1 eV) microprobes using synchrotron radiation are being used to address problems such as chemistry in biological tissues, chemical identification and molecular conformation, environmental biodegradation, mineral phases in geological and astronomical specimens, and electronic properties of novel materials. Infrared synchrotron radiation is focused through, or reflected from, a small spot on the specimen and then analyzed using a spectrometer. Tuning to characteristic vibrational frequencies serves as a sensitive fingerprint for molecular species. Images of the various species are built up by raster scanning the specimen through the small illuminated spot.

38

E-Print Network 3.0 - antifungal surveillance program Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interest in using the budding yeast... the discovery of new chemical entities with broad-spectrum antifungal activity.15 Prior to the 1970s... there was little or no demand...

39

E-Print Network 3.0 - anti-fungal drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: Allergy & sinus medicines and products Feminine anti-fungalanti-itch...

40

Neuroimaging for drug addiction and related behaviors  

SciTech Connect (OSTI)

In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

2011-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Antiretroviral drugs  

Science Journals Connector (OSTI)

In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3?-azido-2?,3?-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The \\{INIs\\} (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.

Erik De Clercq

2010-01-01T23:59:59.000Z

42

A Novel Nuclear Magnetic Resonance (NMR) Imaging Method for Measuring the Water Front Penetration Rate in Hydrophilic Polymer Matrix Capsule Plugs and Its Role in Drug Release  

Science Journals Connector (OSTI)

An NMR imaging method was developed to estimate the rate of water movement in slow-release capsule ... transverse plane of each plug. The water penetration rate was determined by comparison of the cut ... the plu...

Muhammad Ashraf; Virginia L. luorno; David Coffin-Beach…

1994-05-01T23:59:59.000Z

43

In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine  

Science Journals Connector (OSTI)

The recent advances in nanotechnology have a great potential to improve the ... wavelength. Future innovation in cancer imaging by nanotechnology and novel measurement technology will provide great ... in basic m...

Motohiro Takeda; Hiroshi Tada; Hideo Higuchi; Yoshio Kobayashi…

2008-04-01T23:59:59.000Z

44

Commercialization and Late-Stage Development of a Semisynthetic Antifungal API: Anidulafungin/d-Fructose (Eraxis)  

Science Journals Connector (OSTI)

Commercialization and Late-Stage Development of a Semisynthetic Antifungal API: Anidulafungin/d-Fructose (Eraxis) ... In first-generation processes, the reaction medium was initially quenched into acetonitrile to precipitate crude 1. ... Clarification, however, is necessary for this API to render it speck-free from extraneous particulate matter, but armed with the above information the initial dissolution process operation was carried out at the lower end of the allowable process range to facilitate minimal formation of 9 during processing as a practical compromise. ...

Timothy Norris; John VanAlsten; Stephen Hubbs; Marcus Ewing; Weiling Cai; Matthew L. Jorgensen; Jon Bordner; Grace O. Jensen

2008-04-29T23:59:59.000Z

45

Japan Retools Drug Research  

Science Journals Connector (OSTI)

Japan Retools Drug Research ... Like Takeda’s stock price, Japan’s drug R&D engine—flagging in recent years—appears to be recovering. ...

JEAN-FRANÇOIS TREMBLAY

2013-08-05T23:59:59.000Z

46

Biogenic silver nanoparticles synthesised from Zingiber officinale and its antifungal properties  

Science Journals Connector (OSTI)

A silver particle at the nanoscale level behaves as an effective antimicrobial agent and offers numerous applications in biosensing and medicine. The current study unveils the effect of rhizome of Zingiber officinale and its silver nanoparticles against the growth and hydrolytic enzyme of two lethal moulds, Alternaria alternata and Curvularia lunata. The rhizome of Zingiber officinale was extracted under aseptic conditions to get cold distilled water and silver nanoparticle extracts in order to check the effect on inhibition of cell mass formation and protease activity of Curvularia lunata and Alternaria alternata. The formation of silver nanoparticles was confirmed by UV-Vis absorption spectroscopy and scanning electron microscopy. The obtained results showed that the highest tested concentration (2%) of Zingiber officinale in cold distilled water and silver nanoparticle extracts strongly inhibited the cell mass formation as well as protease activity in test organisms. The silver nanoparticle extract showed potent antifungal activity when compared to cold distilled water extract. The study unravels the antifungal property of Zingiber officinale and its biogenically synthesised silver nanoparticles that can be exploited further for therapeutical and other industrial applications.

Malini Soundararajan; Neha Deora; Lynette Lincoln; Purandhi Roopmani; Shikha Gupta; Rajatha Shambu

2014-01-01T23:59:59.000Z

47

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

48

NCI Image-Guided Drug Delivery Summit  

Science Journals Connector (OSTI)

...effects on human health and quality of life. Implications for...statisticians, mathematicians, engineers, and computer scientists...mathematicians, statisticians, and engineers in addition to computer scientists...Sequence verification as quality control step for production...

Pushpa Tandon and Keyvan Farahani

2011-01-15T23:59:59.000Z

49

Light Sources Help Discover New Drug Against Melanoma | Department of  

Broader source: Energy.gov (indexed) [DOE]

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

50

Liposomes in Drug Targeting  

Science Journals Connector (OSTI)

Transport of drugs to target tissues, cells or subcellular organelles by the use of carrier systems is now a recognized useful method of improving drug selectivity. The types of carrier that have been proposed...

G. Gregoriadis

1980-01-01T23:59:59.000Z

51

Orthopaedic Implant & Imaging Laboratory Our laboratory is dedicated to exploring the  

E-Print Network [OSTI]

on tissue biocompatibility Composite of polymetric, metallic and ceramic materials with drug loading coating with nanoceramic matrix for controlled drug release Molecular and Cellular Imaging PET/CT Imaging

Berdichevsky, Victor

52

Drug Conjugates Lure Investment  

Science Journals Connector (OSTI)

Drug Conjugates Lure Investment ... Only two antibody-drug conjugates are on the market— Roche’s Kadcyla for breast cancer and Seattle Genetics’s Adcetris for lymphoma—but developers are stepping up investment in this new drug class. ... The new plant is part of a larger investment by the company in biologics manufacturing (see page 17). ...

ANN THAYER

2013-10-21T23:59:59.000Z

53

Injectable in Situ Cross-Linking Hydrogels for Local Antifungal Therapy  

E-Print Network [OSTI]

Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. ...

Kohane, Daniel S.

54

Evaluation of antibacterial, antifungal and cytotoxic effects of Holothuria scabra from the North Coast of the Persian Gulf  

Science Journals Connector (OSTI)

Summary Bioactive compounds of the gonad, respiration tree, and body wall of the sea cucumber Holothuria scabra collected from the North Coast of the Persian Gulf were extracted using ethyl acetate, methanol and water–methanol mixtures. Extracts were evaluated for their antibacterial and antifungal activities against Aspergillus niger, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The activity was determined using the disc diffusion test. Cytotoxic activities of the extracts were determined by brine shrimp lethality assay. Results showed the existence of an antifungal activity of all extracts against A. niger with MIC ranging from 3 to 9 ?g/mL. The highest antifungal activity was found in respiration tree (methanol) with an inhibition zone of about 50 mm against A. niger at 18 ?g/mL extract concentration. Cytotoxic activity was obtained for methanolic extracts only. Methanol extract of the gonads showed the highest cytotoxic effect (LC50 = 50.5 ?g/mL) continuing with RT methanol extract (LC50 = 70 ?g/mL).

F. Mohammadizadeh; M. Ehsanpor; M. Afkhami; A. Mokhlesi; A. Khazaali; S. Montazeri

2013-01-01T23:59:59.000Z

55

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

56

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

57

Determination of the three-dimensional solution structure of Raphanus sativus Antifungal Protein 1 by 1H NMR  

Science Journals Connector (OSTI)

Raphanus sativus Antifungal Protein 1 (Rs-AFP1) is a 51 amino acid residue plant defensin isolated from radish (Raphanus sativusL.) seeds. The three-dimensional structure in aqueous solution has been determined from two-dimensional 1H NMR data recorded at 500 \\{MHz\\} using the DIANA/REDAC calculation protocols. Experimental constraints consisted of 787 interproton distances extracted from NOE cross-peaks, 89 torsional constraints from 106 vicinal interproton coupling constants and 32 stereospecific assignments of prochiral protons. Further refinement by simulated annealing resulted in a set of 20 structures having pairwise root-mean-square differences of 1.35(±0.35) Å over the backbone heavy atoms and 2.11(±0.46) Å over all heavy atoms. The molecule adopts a compact globular fold comprising an ?-helix from Asn18 till Leu28 and a triple-stranded ?-sheet (?1=Lys2-Arg6, ?2=His33-Tyr38 and ?3=His43-Pro50). The central strand of this ?-sheet is connected by two disulfide bridges (Cys21–Cys45 and Cys25–Cys47) to the ?-helix. The connection between ?-strand 2 and 3 is formed by a type \\{VIa\\} ?-turn. Even the loop (Pro7 to Asn17) between ?-strand 1 and the ?-helix is relatively well defined. The structure of Raphanus sativus Antifungal Protein 1 features all the characteristics of the “cysteine stabilized ?? motif”. A comparison of the complete structure and of the regions important for interaction with the fungal receptor according to a mutational study, is made with the structure of ?-thionin, a plant defensin that has no antifungal activity. It is concluded that this interaction is both electrostatic and specific, and some possible scenarios for the mode of action are given.

Franky Fant; Wim Vranken; Willem Broekaert; Frans Borremans

1998-01-01T23:59:59.000Z

58

Illicit drugs in the environment  

Science Journals Connector (OSTI)

...Nick Voulvoulis Illicit drugs in the environment Ettore Zuccato Sara Castiglioni...but risks for human health and the environment cannot be excluded. Morphine, cocaine...time. illicit drugs|drugs of abuse|environment|sewage treatment plant|wastewater...

2009-01-01T23:59:59.000Z

59

Neutron crystallography aids drug design  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a...

60

drug safety monitoring (DSM)  

Science Journals Connector (OSTI)

Active surveillance for drug safety (in contrast to spontaneous report system); active surveillance systems usually have higher response rates than “passive” systems such as the yellow card programme; ? see also

Dr. med. Dr. phil. Gerhard Nahler

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Career Opportunities in Biotechnology and Drug Developmentand Drug Development  

E-Print Network [OSTI]

Career Opportunities in Biotechnology and Drug Developmentand Drug Development Career Opportunities.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 1 #12-inflammatories www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development

Puglisi, Joseph

62

Macrophage Reporter Cell Assay for Screening Immunopharmacological Activity of Cell Wall-Active Antifungals  

Science Journals Connector (OSTI)

...a modification of methods described by Wheeler and Fink (3) for evaluating macrophage...1726-1733. doi: 10.1086/314495 . 3. Wheeler, RT , and GR Fink. 2006. A drug-sensitive...176-185. doi: 10.1086/589304 . 5. Wheeler, RT , D Kombe, SD Agarwala, and GR...

Russell E. Lewis; Guangling Liao; Katherine Young; Cameron Douglas; Dimitrios P. Kontoyiannis

2014-01-06T23:59:59.000Z

63

Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry  

SciTech Connect (OSTI)

A highly conserved plant defensin MtDef4 potently inhibits the growth of a filamentous fungus Fusarium graminearum. MtDef4 is internalized by cells of F. graminearum. To determine its mechanism of fungal cell entry and antifungal action, NMR solution structure of MtDef4 has been determined. The analysis of its structure has revealed a positively charged patch on the surface of the protein consisting of arginine residues in its ?-core signature, a major determinant of the antifungal activity of MtDef4. Here, we report functional analysis of the RGFRRR motif of the ?-core signature of MtDef4. The replacement of RGFRRR to AAAARR or to RGFRAA not only abolishes fungal cell entry but also results in loss of the antifungal activity of MtDef4. MtDef4 binds strongly to phosphatidic acid (PA), a precursor for the biosynthesis of membrane phospholipids and a signaling lipid known to recruit cytosolic proteins to membranes. Mutations of RGFRRR which abolish fungal cell entry of MtDef4 also impair its binding to PA. Our results suggest that RGFRRR motif is a translocation signal for entry of MtDef4 into fungal cells and that this positively charged motif likely mediates interaction of this defensin with PA as part of its antifungal action.

Sagaram, Uma S.; El-Mounadi, Kaoutar; Buchko, Garry W.; Berg, Howard R.; Kaur, Jagdeep; Pandurangi, Raghoottama; Smith, Thomas J.; Shah, Dilip

2013-12-04T23:59:59.000Z

64

Marketing of New Drugs  

Science Journals Connector (OSTI)

Marketing of New Drugs ... But there was no doubt an excess of expenditure for promotional purposes in recent years and the industry is gradually reducing this because the sales department cannot ask for the marketing of as many new products has it did in the past. ...

PAUL DE HAEN

1964-10-12T23:59:59.000Z

65

Endocytosis-Mediated Vacuolar Accumulation of the Human ApoE Apolipoprotein-Derived ApoEdpL-W Antimicrobial Peptide Contributes to Its Antifungal Activity in Candida albicans  

Science Journals Connector (OSTI)

...of genes related to DNA replication and repair. Finally, the exposure of C. albicans...profiles of Candida albicans cortical actin patch mutants reflect their cellular defects...2010. An insight into the antifungal pipeline: selected new molecules and beyond...

Tristan Rossignol; Bridie Kelly; Curtis Dobson; Christophe d'Enfert

2011-08-01T23:59:59.000Z

66

Candidate Radiation Drugs Inch Forward  

Science Journals Connector (OSTI)

Candidate Radiation Drugs Inch Forward 10.1126/science.331.6024...radiation, workers at the damaged Fukushima nuclear plant wear protective gear...Candidate radiation drugs inch forward. | News | 0 (E)-4-carboxystyryl-4-chlorobenzylsulfone...

Yudhijit Bhattacharjee

2011-03-25T23:59:59.000Z

67

Drug Testing for DOE Positions | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact...

68

Tiny images  

E-Print Network [OSTI]

The human visual system is remarkably tolerant to degradations in image resolution: in a scene recognition task, human performance is similar whether $32 \\times 32$ color images or multi-mega pixel images are used. With ...

Torralba, Antonio

2007-04-23T23:59:59.000Z

69

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease.– Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

70

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

71

Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia  

E-Print Network [OSTI]

It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging ...

Purdon, Patrick Lee

72

People Images  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Images People Images Several hundred of the 1700 U.S. scientists contributing to the LHC accelerator and experiments gathered in June 2008 in CERN's building 40 CE0252 Joel...

73

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle  

Science Journals Connector (OSTI)

...fluorescence imaging system (FIS) with excitation...nm). For the detection of macrophages...for a cellular vehicle in a drug delivery system so as to control...controlled release system using intraperitoneal...as a cellular vehicle. | The lymphoid...

Yuzuru Ikehara; Toru Niwa; Le Biao; Sanae Kabata Ikehara; Norifumi Ohashi; Takeshi Kobayashi; Yoshitaka Shimizu; Naoya Kojima; and Hayao Nakanishi

2006-09-01T23:59:59.000Z

74

Clinton plan to speed cancer drug approval  

Science Journals Connector (OSTI)

Clinton plan to speed cancer drug approval ... Accelerated approval and three other proposals "will affect at least 100 drugs now being studied," he notes, cutting FDA review time for some of these drugs from 12 months to six months. ...

1996-04-08T23:59:59.000Z

75

Report on AOAC, Narcotic and Dangerous Drugs  

Science Journals Connector (OSTI)

......Report on AOAC, narcotic and dangerous drugs. | Journal Article...Report on AOAC, Narcotic and Dangerous Drugs by Anthony Romano...Bureau of Narcotics and Dangerous Drugs, Miami, Florida 33132...substances affect- ing public health." The AOAC itself maintains......

Anthony Romano; Jr.

1972-05-01T23:59:59.000Z

76

Clinical Manifestations of Allergic Diseases: Drug Hypersensitivity  

Science Journals Connector (OSTI)

Drug allergies are those adverse drug reactions that are mediated by the specific immune system. Primary sensitization may involve T-cells alone or both T and B-cells with consecutive production of drug specif...

Benno Schnyder; Werner J. Pichler

2009-01-01T23:59:59.000Z

77

Optical imaging for the new grammar of drug discovery  

Science Journals Connector (OSTI)

...the tumour region was observed only for the probes with the warhead acyloxymethyl ketone (AOMK) group. By contrast, control...reactive functional group. The ability to label caspase-3 in intact cells was successfully tested upon apoptosis induction of Jurkat...

Thomas Krucker; Britto S. Sandanaraj

2011-01-01T23:59:59.000Z

78

THUMBS DOWN ON DRUG WAR WEAPON  

Science Journals Connector (OSTI)

THUMBS DOWN ON DRUG WAR WEAPON ... Mycoherbicides have been viewed as a potentially potent weapon in the worldwide war on illicit drugs. ...

CHERYL HOGUE

2011-12-05T23:59:59.000Z

79

Plan to speed up drug review approved  

Science Journals Connector (OSTI)

Plan to speed up drug review approved ... Proposed changes in the New Drug Application procedure will shorten review times, reduce paperwork, and save money ...

DAVID HANSON

1982-07-12T23:59:59.000Z

80

Image Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mosaic of earth and sky images Mosaic of earth and sky images Image Resources Free image resources covering energy, environment, and general science. Here are some links to energy- and environment-related photographic databases. Berkeley Lab Photo Archive Berkeley Lab's online digital image collection. National Science Digital Library (NSDL) NSDL is the Nation's online library for education and research in science, technology, engineering, and mathematics. The World Bank Group Photo Library A distinctive collection of over 11,000 images that illustrate development through topics such as Agriculture, Education, Environment, Health, Trade and more. Calisphere Compiles the digital collections of libraries, museums, and cultural heritage organizations across California, and organizes them by theme, such

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

EMSL - Imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

imaging en Diffusional Motion of Redox Centers in Carbonate Electrolytes . http:www.emsl.pnl.govemslwebpublicationsdiffusional-motion-redox-centers-carbonate-electrolytes

82

The overdose of drugs in Japan  

Science Journals Connector (OSTI)

... spenders on prescription drugs. Among the top-selling drugs are anti-cancer agents peculiar to Japan that are of questionable efficacy and yet have sales of hundreds of millions of dollars ... -cancer drugs in other developed nations. Moreover, several of the drugs sold only in Japan have serious side effects. Justification of these contentions is to be found in Tables ...

Masanori Fukushima

1989-12-28T23:59:59.000Z

83

Data Image  

Science Journals Connector (OSTI)

Data image refers to the sum of all information 74/100,000 available in all datasets linked to a specific name; to all those who have access to databases that name is actually the data image of the real person...

2008-01-01T23:59:59.000Z

84

Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance  

E-Print Network [OSTI]

as: Wu: Drug metabolizing enzyme activities versus geneticRoles for Old Molecules: Enzymes in Personalized Medicine,Access Drug metabolizing enzyme activities versus genetic

Wu, Alan HB

2011-01-01T23:59:59.000Z

85

A Key Target for Diabetes Drugs | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

86

Adulteration of Drugs-of-Abuse Specimens  

Science Journals Connector (OSTI)

Persons abusing drugs attempt to adulterate urine specimens in ... fluid and various detoxifying agents available through the Internet is a common practice. Household chemicals such ... mask drug testing if the c...

Amitava Dasgupta

2005-01-01T23:59:59.000Z

87

Vetting Threats To Safe Drug Supplies  

Science Journals Connector (OSTI)

Vetting Threats To Safe Drug Supplies ... Representatives from government, drug companies, and national and international law enforcement agencies struggled to characterize what all agree is a large, growing, and frustratingly nebulous threat to public health and safety. ...

RICK MULLIN

2012-04-01T23:59:59.000Z

88

Prostate drug Proscar cleared for marketing  

Science Journals Connector (OSTI)

Prostate drug Proscar cleared for marketing ... The Food & Drug Administration has approved marketing of a pill developed by Merck & Co., Rahway, N.J., as an alternative to surgery for treating enlargement of the prostate gland. ...

STEPHEN STINSON

1992-06-29T23:59:59.000Z

89

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-Based Nanomedicine Platforms for Drug Delivery. Protein-Based Nanomedicine Platforms for Drug Delivery. Abstract: Drug delivery systems have been developed for many years,...

90

The pipeline and future of drug development in schizophrenia  

E-Print Network [OSTI]

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

91

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

92

Drugs: A tangled web of targets  

Science Journals Connector (OSTI)

... was a good year. The US Food and Drug Administration (FDA) had just approved memantine, the first in a class of drugs that reduces abnormal brain activity. Scientists had ... based on each, and the field seemed to be moving in the right direction. Memantine is one of several drugs on the market in Europe and the United States that ...

Lauren Gravitz

2011-07-13T23:59:59.000Z

93

Iontophoretic drug delivery system: A review  

Science Journals Connector (OSTI)

Among the recent developments in the field of transdermal drug delivery, iontophoresis has emerged as a very promising tool for this purpose. Various studies have been performed on drug delivery through the skin using electric current. Iontophoresis ... Keywords: Iontophoresis, iontophoretic systems, transdermal drug delivery

Ajay Semalty; Mona Semalty; Ranjit Singh; Shailendra K. Saraf; Shubhini Saraf

2007-09-01T23:59:59.000Z

94

Designing Drugs on Supercomputers | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Designing Drugs on Supercomputers Designing Drugs on Supercomputers Advanced Scientific Computing Research (ASCR) ASCR Home About Research Facilities Science Highlights Benefits of ASCR Funding Opportunities Advanced Scientific Computing Advisory Committee (ASCAC) News & Resources Contact Information Advanced Scientific Computing Research U.S. Department of Energy SC-21/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-7486 F: (301) 903-4846 E: sc.ascr@science.doe.gov More Information » October 2012 Designing Drugs on Supercomputers Researchers use Oak Ridge Leadership Computing Facility to accelerate drug discovery. Print Text Size: A A A Subscribe FeedbackShare Page Click to enlarge photo. Enlarge Photo Image courtesy of University of Tennessee-ORNL Center for Molecular

95

History Images  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

History Images History Images Los Alamos History in Images Los Alamos has a proud history and heritage of almost 70 years of science and innovation. The people of the Laboratory work on advanced technologies to provide the best scientific and engineering solutions to many of the nation's most crucial security challenges. Click thumbnails to enlarge. Photos arranged by most recent first, horizontal formats before vertical. See Flickr for more sizes and details. Back in the day Back in the day LA bridge in Los Alamos LA bridge in Los Alamos 1945 Army-Navy "E" Award 1945 Army-Navy "E" Award Louis Rosen Louis Rosen Bob Van Ness Robert Kuckuck and Michael Anastasio Bob Van Ness Robert Kuckuck and Michael Anastasio TA-18 TA-18 Elmer Island TU-4 assembly area Elmer Island TU-4 assembly area

96

Membrane protein kit may lead to better targeted drugs | Argonne National  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne scientists received an R&D100 Award for using Rhodobacter to develop a new system for growing membrane proteins used in drug discovery research. Image by Sheng-Wen Chui, University of Oxford. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne

97

Imaging bolometer  

DOE Patents [OSTI]

Radiation-hard, steady-state imaging bolometer. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas.

Wurden, Glen A. (Los Alamos, NM)

1999-01-01T23:59:59.000Z

98

Imaging bolometer  

DOE Patents [OSTI]

Radiation-hard, steady-state imaging bolometer is disclosed. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas. 2 figs.

Wurden, G.A.

1999-01-19T23:59:59.000Z

99

GERMAN REFORMS AFFECT DRUG R&D  

Science Journals Connector (OSTI)

Under the national health care system, insurers pay for consumers' prescription drugs and get a 6% rebate from manufacturers to help contain costs; the remainder ... ...

PATRICIA SHORT

2003-09-01T23:59:59.000Z

100

Was Sherlock Holmes a Drug Addict?  

Science Journals Connector (OSTI)

... AN occasional correspondent contributes an amusing article to The Lancet of December 26 entitled “Was Sherlock Holmes a Drug Addict?”, as his friend Dr. Watson ...

1937-01-02T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS  

E-Print Network [OSTI]

Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

Flynn, Colleen A.

2011-12-31T23:59:59.000Z

102

Mexico’s “ley de narcomenudeo” drug policy reform and the international drug control regime  

Science Journals Connector (OSTI)

It has been over half a century since the landmark Single Convention on Narcotic Drugs was adopted, for the first time unifying international drug policy under a single treaty aimed at limiting use, manufacture, ...

Tim K Mackey; Daniel Werb; Leo Beletsky; Gudelia Rangel…

2014-11-01T23:59:59.000Z

103

RSNA 2002: Image Fusion Image Fusion  

E-Print Network [OSTI]

of anatomical feature #12;RSNA 2002: Image Fusion Types of Data to be Registered Anatomic CT, MRI, US DigitizedRSNA 2002: Image Fusion Image Fusion: Introduction to the Technology Charles A. Pelizzari, Ph.D. Department of Radiation and Cellular Oncology The University of Chicago #12;RSNA 2002: Image Fusion "Fusion

Pelizzari, Charles A.

104

Nanometric Optical Imaging Frontiers in Chemical Imaging  

E-Print Network [OSTI]

Nanometric Optical Imaging Frontiers in Chemical Imaging Seminar Series Presented by... Professor growing field which has provided for nanometric optical imaging in the near-field. Even though a variety of techniques are being developed with nanometric optical imaging potential, near-field optics remains the most

105

Network predicting drug's anatomical therapeutic chemical code  

Science Journals Connector (OSTI)

......validated on four drug datasets with various target...couple receptors and nuclear receptors. We found...well-collected drug datasets, the ATC-code assignments...For example, the dataset in Yamanishi et al...receptors (GPCRs) and nuclear receptors (NRs......

Yong-Cui Wang; Shi-Long Chen; Nai-Yang Deng; Yong Wang

2013-05-15T23:59:59.000Z

106

The World of Youthful Drug Use  

E-Print Network [OSTI]

they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

2000-04-01T23:59:59.000Z

107

MR imaging techniques for nano-pathophysiology and theranostics  

Science Journals Connector (OSTI)

Abstract The advent of nanoparticle \\{DDSs\\} (drug delivery systems, nano-DDSs) is opening new pathways to understanding physiology and pathophysiology at the nanometer scale. A nano-DDS can be used to deliver higher local concentrations of drugs to a target region and magnify therapeutic effects. However, interstitial cells or fibrosis in intractable tumors, as occurs in pancreatic or scirrhous stomach cancer, tend to impede nanoparticle delivery. Thus, it is critical to optimize the type and size of nanoparticles to reach the target. High-resolution 3D imaging provides a means of “seeing” the nanoparticle distribution and therapeutic effects. We introduce the concept of “nano-pathophysiological imaging” as a strategy for theranostics. The strategy consists of selecting an appropriate nano-DDS and rapidly evaluating drug effects in vivo to guide the next round of therapy. In this article we classify nano-DDSs by component carrier materials and present an overview of the significance of nano-pathophysiological MRI.

Kevin M. Bennett; Jun-ichiro Jo; Horacio Cabral; Rumiana Bakalova; Ichio Aoki

2014-01-01T23:59:59.000Z

108

Split image optical display  

DOE Patents [OSTI]

A video image is displayed from an optical panel by splitting the image into a plurality of image components, and then projecting the image components through corresponding portions of the panel to collectively form the image. Depth of the display is correspondingly reduced.

Veligdan, James T. (Manorville, NY)

2007-05-29T23:59:59.000Z

109

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

110

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

111

Nano compartments may aid drug delivery, catalyst design > Archived...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nano compartments may aid drug delivery, catalyst design April 18th, 2013 By Bill Steele Spongelike nanoparticles whose pores can be filled with drugs offer the promise of drug...

112

E-Print Network 3.0 - adverse antiepileptic drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

113

Shedding Light on Protein Drug Interactions | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science Highlights Archives: 2013 | 2012 | 2011 | 2010 Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Shedding Light on Protein Drug Interactions JANUARY 23, 2008 Bookmark and Share In this e-coli cell, the proteins (shown in blue) crowd around ribosomes (purple). These regions have a high concentration of protein, typically greater than 30 percent, which limits the ensemble of states into which the proteins can bend themselves. Download hi-res image.) Proteins, the biological molecules that are involved in virtually every action of every organism, may themselves move in surprising ways, according to a recent study carried out at the Biophysics Collaborative Access Team x-ray beamline 18-ID at the Advanced Photon Source, a national user

114

millionImaging research infrastructure  

E-Print Network [OSTI]

Centre for Imaging Technology Commercialization, led by Aaron Fenster $34 million Hybrid imaging infrastructureimaging #12;IMAGING Investment $100 millionImaging research infrastructure Formation

Denham, Graham

115

Optical measurement of drug concentrations in tissue  

SciTech Connect (OSTI)

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The aim of this project was to develop noninvasive fiber-optic methods for measuring drug concentrations in tissue. Such a system would make possible the study of chemotherapy drug kinetics at specific, targeted locations in the body after the drug is administered. The major result of this project is the development of techniques for measuring changes in absorption of a medium with unknown scattering properties. The developed method was verified by testing on several media with scattering properties in the range typically found for tissue.

Mourant, J.R.; Bigio, I.J.; Jack, D.A.; Johnson, T.M.; Miller, H.D. [Los Alamos National Lab., NM (United States). Chemical Sciences and Technology Div.

1997-10-01T23:59:59.000Z

116

Book Review of Handbook of Drug Metabolism. Second Edition  

Science Journals Connector (OSTI)

Book Review of Handbook of Drug Metabolism. ... This book is divided into four sections: Fundamentals, Factors Affecting Drug Metabolism, Technologies, and Applications. ...

Jeffrey P. Jones

2009-06-22T23:59:59.000Z

117

Apoferritin-based nanomedicine platform for drug delivery: equilibrium...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

118

Drugs and oil flow through the Eagle Ford Shale.  

E-Print Network [OSTI]

??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region… (more)

Marks, Michael Perry

2014-01-01T23:59:59.000Z

119

Implementation Guidance, Drug Testing - December 3, 2007 | Department...  

Broader source: Energy.gov (indexed) [DOE]

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and...

120

Secretary Bodman's Memorandum Regarding Drug Testing at DOE ...  

Office of Environmental Management (EM)

Secretary Bodman's Memorandum Regarding Drug Testing at DOE Secretary Bodman's Memorandum Regarding Drug Testing at DOE September 14, 2007 In consideration of the report on the...

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Alignment strategies for drug product process development and manufacturing .  

E-Print Network [OSTI]

??The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the… (more)

Garvin, Christopher John

2012-01-01T23:59:59.000Z

122

Memorandum, Drug Testing at DOE - September 14, 2007 | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

on the Consequences of a Positive Drug Test Secretary Bodman's Memorandum Regarding Drug Testing at DOE Environment Worker Health & Safety Nuclear Safety Facility Safety Security...

123

E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

124

Mathematical Modeling of HIV-1 Infection and Drug Therapy  

E-Print Network [OSTI]

also discuss how drug treatment affects the emergence of drug resistance during treatment, and how a low level of virus and latently infected cells can persist in.

2008-12-16T23:59:59.000Z

125

Nuclear magnetic resonance imaging  

Science Journals Connector (OSTI)

Nuclear magnetic resonance imaging (NMRI) is a powerful imaging modality having a range of important applications to medicine and industry. The basic principles of NMRI are reviewed in...

Rothwell, William P

1985-01-01T23:59:59.000Z

126

Quantum-secured imaging  

E-Print Network [OSTI]

We have built an imaging system that uses a photon's position or time-of-flight information to image an object, while using the photon's polarization for security. This ability allows us to obtain an image which is secure against an attack in which the object being imaged intercepts and resends the imaging photons with modified information. Popularly known as "jamming," this type of attack is commonly directed at active imaging systems such as radar. In order to jam our imaging system, the object must disturb the delicate quantum state of the imaging photons, thus introducing statistical errors that reveal its activity.

Mehul Malik; Omar S. Magaña-Loaiza; Robert W. Boyd

2012-12-11T23:59:59.000Z

127

Drug Shows Promise for Advanced Disease  

Science Journals Connector (OSTI)

...session of the congress that the drug memantine significantly slowed the progression...transmit their signals. In contrast, memantine turns down the activity of the so-called...damage in Alzheimer's. In Germany, memantine has been approved for treating dementias...

Jean Marx

2000-07-21T23:59:59.000Z

128

NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM  

E-Print Network [OSTI]

Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ...

Hart, Steven N.

2011-02-22T23:59:59.000Z

129

Conflict of interest over Harvard drug  

Science Journals Connector (OSTI)

... an unusually candid statement released last week by Harvard Medical School, Dean Daniel C. Tosteson acknowledged that a "significant conflict of interest occurred" in a drug study undertaken by ...

Seth Shulman

1988-10-27T23:59:59.000Z

130

Pollution from drug manufacturing: review and perspectives  

Science Journals Connector (OSTI)

...19] and Europe [9,14] as pollution sources, with concentrations of...the picture of pharmaceutical pollution from manufacturing is still highly...for some drugs, possibly even air pollution. 2. Effect studies A number of...

2014-01-01T23:59:59.000Z

131

The Changing Face of Teenage Drug Abuse — The Trend toward Prescription Drugs  

Science Journals Connector (OSTI)

...friends, or on the Internet." They can also get them all too easily from physicians, according to recent data from the National Center on Addiction and Substance Abuse at Columbia University. A 2004 survey of physicians found that 43 percent did not ask about prescription-drug abuse when taking a patient's... Dr. Richard Friedman describes an emerging pattern in drug use by teenagers: illicit street drugs such as “ecstasy” and cocaine are decreasing in popularity, whereas the nonmedical use of certain prescription drugs is on the rise.

Friedman R.A.

2006-04-06T23:59:59.000Z

132

NMR imaging of materials  

SciTech Connect (OSTI)

Interest in the area of NMR imaging has been driven by the widespread success of medical imaging. John M. Listerud of the Pendergrass Diagnostic Research Laboratories, Steven W. Sinton of Lockheed, and Gary P. Drobny of the University of Washington describe the principal image reconstruction methods, factors limiting spatial resolution, and applications of imaging to the study of materials.

Listerud, J.M.; Sinton, S.W.; Drobny, G.P.

1989-01-01T23:59:59.000Z

133

Seismic Imaging and Monitoring  

SciTech Connect (OSTI)

I give an overview of LANL's capability in seismic imaging and monitoring. I present some seismic imaging and monitoring results, including imaging of complex structures, subsalt imaging of Gulf of Mexico, fault/fracture zone imaging for geothermal exploration at the Jemez pueblo, time-lapse imaging of a walkway vertical seismic profiling data for monitoring CO{sub 2} inject at SACROC, and microseismic event locations for monitoring CO{sub 2} injection at Aneth. These examples demonstrate LANL's high-resolution and high-fidelity seismic imaging and monitoring capabilities.

Huang, Lianjie [Los Alamos National Laboratory

2012-07-09T23:59:59.000Z

134

FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX  

E-Print Network [OSTI]

ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of the drug with Neusilin were...

MacLean, Jenifer Anne

2010-12-16T23:59:59.000Z

135

Manhattan Project: Trinity Images  

Office of Scientific and Technical Information (OSTI)

IMAGES IMAGES Trinity Test Site (July 16, 1945) Resources > Photo Gallery The first 0.11 seconds of the Nuclear Age These seven photographs of the Trinity test were taken by time-lapse cameras. The last is 109 milliseconds, or 0.109 seconds, after detonation. Scroll down to view each individual image. The photographs are courtesy the Los Alamos National Laboratory, via the Federation of American Scientists web site. The animation is original to the Office of History and Heritage Resources. The dawn of the Nuclear Age (Trinity image #1) The dawn of the Nuclear Age Trinity image #2 Trinity image #3 Trinity image #4 Trinity image #5 Trinity, 0.09 seconds after detonation (Trinity image #6) Trinity, 0.09 seconds after detonation Trinity, 0.11 seconds after detonation (Trinity image #7)

136

Using a drug-word Stroop task to differentiate recreational from dependent drug use  

E-Print Network [OSTI]

, Garavan H. A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task. Drug Alcohol Depend. 2006;81(3):251–257. 38. Franken IHA, Kroon LY, Wiers RW, Jansen A. Selective...

Smith, Dana G.; Ersche, Karen D.

2014-03-14T23:59:59.000Z

137

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

138

Image registration method for medical image sequences  

DOE Patents [OSTI]

Image registration of low contrast image sequences is provided. In one aspect, a desired region of an image is automatically segmented and only the desired region is registered. Active contours and adaptive thresholding of intensity or edge information may be used to segment the desired regions. A transform function is defined to register the segmented region, and sub-pixel information may be determined using one or more interpolation methods.

Gee, Timothy F.; Goddard, James S.

2013-03-26T23:59:59.000Z

139

Drug Testing for New Clearance Holders  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

140

Drug Testing for New Clearance Holders  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Testing Prerequisite for DOE Security Clearance Applicants Drug Testing Prerequisite for DOE Security Clearance Applicants The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Current Status Clearance Action Test Required? Uncleared - Applicant Grant (Q/L, T/S/C) Yes Previously Cleared DOE-now uncleared DOE Reinstate (Q/L, T/S/C) Yes* Coming from another Federal agency, regardless of clearance status Grant (Q/L, T/S/C) Yes**

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Protein-Based Nanomedicine Platforms for Drug Delivery  

SciTech Connect (OSTI)

Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

2009-08-03T23:59:59.000Z

142

Web Sites with Misinformation about Illicit Drugs  

Science Journals Connector (OSTI)

To the Editor: As part of our research on the relation between the Internet and substance abuse, we have identified several Web sites that promulgate information about illicit drugs. These "partisan" Web sites are easily identified by common search engines if one uses the names of illicit substances... To the Editor: As part of our research on the relation between the Internet and substance abuse, we have identified several Web sites that promulgate information about illicit drugs. These “partisan” Web sites are easily identified by common search ...

2001-08-09T23:59:59.000Z

143

Prescription drug abuse: Problem, policies, and implications  

Science Journals Connector (OSTI)

This article provides an overview on prescription drug abuse and highlights a number of related legislative bills introduced during the 112th Congress in response to this growing epidemic. Prescription drug abuse has emerged as the nation’s fastest growing drug problem. Although prescription drugs have been used effectively and appropriately for decades, deaths from prescription pain medicine in particular have reached epidemic proportions. Bills related to prescription drug abuse introduced during the 112th Congress focus on strengthening provider and consumer education, tracking and monitoring prescription drug abuse, improving data collection on drug overdose fatalities, combating fraud and abuse in Medicare and Medicaid programs, reclassifying drugs to make them more difficult to prescribe and obtain, and enforcing stricter penalties for individuals who operate scam pain clinics and sell pain pills illegitimately. This article underscores the importance of a multifaceted approach to combating prescription drug abuse and concludes with implications for nursing.

Janice Phillips

2013-01-01T23:59:59.000Z

144

Image Segmentation and Uncertainty  

Science Journals Connector (OSTI)

From the Publisher:Presents the first unified theory of image segmentation, written by the winners of the 1985 Pattern Recognition Society medal. Until now, image processing algorithms have always been beset by uncertainties, no one method proving completely ...

Roland 1949- Wilson; Michael Spann

1988-02-01T23:59:59.000Z

145

Estimation theoretical image restoration  

E-Print Network [OSTI]

In this thesis, we have developed an extensive study to evaluate image restoration from a single image, colored or monochromatic. Using a mixture of Gaussian and Poisson noise process, we derived an objective function to ...

Dolne, Jean J

2008-01-01T23:59:59.000Z

146

Drug Innovation "Bridging Molecules and Diseases"  

E-Print Network [OSTI]

in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

Utrecht, Universiteit

147

2012 Women's Contraceptive Drugs and Devices List  

E-Print Network [OSTI]

as the health care reform law, will comply with requirements for Women's Preventive Health Services. This means2012 Women's Contraceptive Drugs and Devices List Aetna Student Health PlansSM Quality health plans plans effective or renewing after August 1, 2012 and subject to the Affordable Care Act, also known

Buehrer, R. Michael

148

Drug smuggling safety tests [July 1, 2006  

E-Print Network [OSTI]

enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

Suslick, Kenneth S.

149

Human Cytomegalovirus Resistance to Antiviral Drugs  

Science Journals Connector (OSTI)

American Society for Microbiology MINIREVIEW MINIREVIEW Human...Resistance to Antiviral Drugs C. Gilbert 1 G. Boivin 1 Corresponding...523-528. 20 Boivin, G., C. Gilbert, A. Gaudreau, I. Greenfield...G., N. Goyette, C. Gilbert, N. Roberts, K. Macey...

C. Gilbert; G. Boivin

2005-03-01T23:59:59.000Z

150

Genomics-based drug discovery venture  

Science Journals Connector (OSTI)

Genomics-based drug discovery venture ... The Cambridge, Mass.-based company calls its DiscoverEase program "functional genomics"—designed to isolate and rapidly determine not only genes but also the related functions of critical proteins. ... Other genomics programs sequence vast amounts of human genetic information. ...

ANN THAYER

1996-10-07T23:59:59.000Z

151

Genomics Rises To Drug Discovery Challenge  

Science Journals Connector (OSTI)

Genomics Rises To Drug Discovery Challenge ... Functional genomics and functional proteomics provide a set of powerful tools to help identify novel cellular targets ... With pharmaceutical companies and biotechnology firms always looking for ways to discover new medicines more quickly and more efficiently, they are increasingly turning to new genomics and proteomics technologies to speed things along. ...

STU BORMAN

1999-04-19T23:59:59.000Z

152

Video image position determination  

DOE Patents [OSTI]

An optical beam position controller in which a video camera captures an image of the beam in its video frames, and conveys those images to a processing board which calculates the centroid coordinates for the image. The image coordinates are used by motor controllers and stepper motors to position the beam in a predetermined alignment. In one embodiment, system noise, used in conjunction with Bernoulli trials, yields higher resolution centroid coordinates.

Christensen, Wynn (Los Alamos, NM); Anderson, Forrest L. (Bernalillo, NM); Kortegaard, Birchard L. (Los Alamos, NM)

1991-01-01T23:59:59.000Z

153

Dual Plane Imaging  

E-Print Network [OSTI]

We outline a technique called Dual Plane Imaging which should significantly improve images which would otherwise be blurred due to atmospheric turbulence. The technique involves capturing all the spatial, directional and temporal information about the arriving photons and processing the data afterwards to produce the sharpened images. The technique has particular relevance for imaging at around 400-1000nm on extremely large telescopes (ELTs).

Parry, Ian

2015-01-01T23:59:59.000Z

154

Aerosolized Delivery of Antifungal Agents  

E-Print Network [OSTI]

toxicities, such as cough, which is a common adverse effecttension, can greatly influence the occurrence of cough.Induction of cough can occur when the osmolality is less

Le, Jennifer; Schiller, Daryl S.

2010-01-01T23:59:59.000Z

155

Magnetic Imaging Wolfgang Kuch  

E-Print Network [OSTI]

Magnetic Imaging Wolfgang Kuch Freie Universit¨at Berlin, Institut f¨ur Experimentalphysik, Arnimallee 14, 14195 Berlin, Germany kuch@physik.fu-berlin.de Abstract. Imaging of magnetic domains has- ern techniques is used nowadays routinely for magnetic imaging of magnetic ma- terials

Kuch, Wolfgang

156

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

157

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

158

Near-electrode imager  

DOE Patents [OSTI]

An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager uses the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

Rathke, Jerome W. (Lockport, IL); Klingler, Robert J. (Westmont, IL); Woelk, Klaus (Wachtberg, DE); Gerald, II, Rex E. (Brookfield, IL)

2000-01-01T23:59:59.000Z

159

Medical imaging systems  

DOE Patents [OSTI]

A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

Frangioni, John V

2013-06-25T23:59:59.000Z

160

Nanotechnology for Molecular Imaging and Image-Guided Surgery  

Science Journals Connector (OSTI)

Recent development in bioconjugated nanoparticles opens new opportunities for in-vivo molecular imaging and image-guided cancer surgery.

Nie, Shuming

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Automation in image cytometry : continuous HCS and kinetic image cytometry  

E-Print Network [OSTI]

OF CALIFORNIA, SAN DIEGO Automation in Image Cytometry:xiv Abstract of Dissertation Automation in Image Cytometry:

Charlot, David J.

2012-01-01T23:59:59.000Z

162

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing  

Science Journals Connector (OSTI)

...mellonella insect model of infection (33). Larvae of the wax moth G. mellonella are extremely sensitive to P. aeruginosa...2006. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious...

Francesco Imperi; Francesco Massai; Cejoice Ramachandran Pillai; Francesca Longo; Elisabetta Zennaro; Giordano Rampioni; Paolo Visca; Livia Leoni

2012-12-17T23:59:59.000Z

163

SNAP Image Gallery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Images Images Cutaway image of SNAP A cutaway illustration of SNAP showing some of the interior optics. Cutaway image of SNAP A computer generated cutaway illustration of SNAP Cutaway image of SNAP's primary mirror A computer generated cutaway illustration of SNAP's primary mirror image of SNAP spacecraft A computer generated illustration of the SNAP spacecraft computer generated image of SNAP A computer generated illustration of SNAP Before-and-after pictures (and Hubble Space Telescope picture) of a high-redshift supernovae discovered by the Supernova Cosmology Project in March, 1998. Before-and-after pictures (and Hubble Space Telescope picture) of a high-redshift supernovae discovered in March, 1998. This observaton showed that the expansion of the universe was accelerarting. Credit: High Redshift Supernova Search Supernova Cosmology Project

164

Deaths Involving MDMA and the Concomitant Use of Pharmaceutical Drugs  

Science Journals Connector (OSTI)

......are associated with chronic abuse resulting in chronic heart disease...maceutical drug, usually young males concurrently using ec...Micromedex Healthcare Series [Internet database]. 19742010. 20...Postmortem toxicology of drugs of abuse. Forensic Sci. Int. 142......

J.L. Pilgrim; D. Gerostamoulos; Olaf H. Drummer

2011-05-01T23:59:59.000Z

165

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

Yu, Xiao

2012-07-16T23:59:59.000Z

166

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

167

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...May 2014 review-article Minireview Energy Metabolism and Drug Efflux in Mycobacterium...availability of ATP. This suggests that energy metabolism and ATP production through...We also highlight the importance of energy metabolism in mediating drug tolerance...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

168

E-Print Network 3.0 - analyzing drug combination Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, Saadat Anwar2 , Shanshan Liang2... : Identifying drug-drug interactions is a critical process in drug administration and ... Source: Baral, Chitta - Department of Computer...

169

E-Print Network 3.0 - antiviral drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Opin Emerg Drugs . Author manuscript Emerging drugs for hepatitis B Summary: and to design new trials of combination therapy to delay drug resistance. In the future, antiviral...

170

E-Print Network 3.0 - anticancer drug levels Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chemistry 7 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- Summary: is responsible for metabol- ism of drug B. Such drug...

171

E-Print Network 3.0 - anticancer drug topotecan Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

172

E-Print Network 3.0 - anticancer drugs mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

173

E-Print Network 3.0 - anticancer drug roscovitine Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

174

E-Print Network 3.0 - anticancer drug mitoxantrone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

175

Sexuality Under the Influence: The Queer Pleasures of Illicit Drugs in Transatlantic Gay and Lesbian Culture  

E-Print Network [OSTI]

of Illicit Drugs in Transatlantic Gay and Lesbian Culture Aof Illicit Drugs in Transatlantic Gay and Lesbian Culture byof Illicit Drugs in Transatlantic Gay and Lesbian Culture

Randolph, Patrick

2011-01-01T23:59:59.000Z

176

Drug-Free Federal Workplace Testing Implementation Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

1988-07-29T23:59:59.000Z

177

Division of Human Resources Alcohol & Drug Testing (CDL)  

E-Print Network [OSTI]

Division of Human Resources Alcohol & Drug Testing (CDL) Definitions of Terms Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 The definitions listed below are for common words/phrases used in the alcohol and drug testing procedures. Accident - An occurrence associated

Meyers, Steven D.

178

The University of Mississippi Drug and Alcohol Testing  

E-Print Network [OSTI]

The University of Mississippi Drug and Alcohol Testing Summary/Purpose: In furtherance of the University's interest to maintain a drug-free workplace, the University reserves the right to test any of the University's interest to maintain a drug-free workplace, the University reserves the right to test any

Tchumper, Gregory S.

179

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps  

E-Print Network [OSTI]

Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

Sankaranarayanan, Sriram

180

Media's Positive and Negative Frames in Reporting Celebrity Deaths From Illegal Drug Overdoses Versus Prescription Drug Overdoses  

E-Print Network [OSTI]

This study compared the celebrity illegal drug overdose deaths of River Phoenix, Chris Farley, and Brad Renfro to the prescription drug overdose deaths of Anna Nicole Smith, Heath Ledger, and Brittany Murphy. This research used quantitative...

Wood, Michelle

2011-12-31T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

182

ARM - Measurement - Hydrometeor image  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

image image ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send Measurement : Hydrometeor image Images of hydrometeors from which one can derive characteristics such as size and shape. Categories Cloud Properties Instruments The above measurement is considered scientifically relevant for the following instruments. Refer to the datastream (netcdf) file headers of each instrument for a list of all available measurements, including those recorded for diagnostic or quality assurance purposes. Field Campaign Instruments LEARJET : Lear Jet PARTIMG : Particle imager UAV-PROTEUS-MICRO : Proteus Cloud Microphysics Instruments SPEC-CPI : Stratton Park Engineering Company - Cloud particle imager UAV-PROTEUS : UAV Proteus

183

Video Toroid Cavity Imager  

DOE Patents [OSTI]

A video toroid cavity imager for in situ measurement of electrochemical properties of an electrolytic material sample includes a cylindrical toroid cavity resonator containing the sample and employs NMR and video imaging for providing high-resolution spectral and visual information of molecular characteristics of the sample on a real-time basis. A large magnetic field is applied to the sample under controlled temperature and pressure conditions to simultaneously provide NMR spectroscopy and video imaging capabilities for investigating electrochemical transformations of materials or the evolution of long-range molecular aggregation during cooling of hydrocarbon melts. The video toroid cavity imager includes a miniature commercial video camera with an adjustable lens, a modified compression coin cell imager with a fiat circular principal detector element, and a sample mounted on a transparent circular glass disk, and provides NMR information as well as a video image of a sample, such as a polymer film, with micrometer resolution.

Gerald, Rex E. II; Sanchez, Jairo; Rathke, Jerome W.

2004-08-10T23:59:59.000Z

184

High-Cost Generic Drugs — Implications for Patients and Policymakers  

Science Journals Connector (OSTI)

It is well known that new brand-name drugs are often expensive, but U.S. health care is also witnessing a lesser-known but growing and seemingly paradoxical phenomenon: certain older drugs, many of which are generic and not protected by patents or market exclusivity, are now also extremely expensive... Some older generic drugs have become very expensive, owing to factors including drug shortages, supply disruptions, and consolidations in the generic-drug industry. But generics manufacturers that legally obtain a market monopoly can also unilaterally raise prices.

Alpern J.D.Stauffer W.M.Kesselheim A.S.

2014-11-13T23:59:59.000Z

185

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

186

Manhattan Project: Places Images  

Office of Scientific and Technical Information (OSTI)

PLACES IMAGES PLACES IMAGES Resources > Photo Gallery Scroll down to see each of these images individually. The images are: 1. Remains of a Shinto Shrine, Nagasaki, October 1945 (courtesy the United States Marine Corps, Lieutenant R. J. Battersby, photographer, via the National Archives); 2. University of California, Berkeley, 1940 (courtesy the Lawrence Berkeley National Laboratory); 3. Aerial photograph of the Trinity Site after the test (courtesy the Federation of American Scientists); 4. Aerial photograph of Hiroshima before the bombing; 5. Columbia University, 1903 (courtesy the Library of Congress; this photograph originated from the Detroit Publishing Company; it was a 1949 gift to the Library of Congress from the State Historical Society of Colorado).

187

Quantitative luminescence imaging system  

DOE Patents [OSTI]

The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.

Erwin, David N. (San Antonio, TX); Kiel, Johnathan L. (San Antonio, TX); Batishko, Charles R. (West Richland, WA); Stahl, Kurt A. (Richland, WA)

1990-01-01T23:59:59.000Z

188

Quantitative luminescence imaging system  

DOE Patents [OSTI]

The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopic imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber. 22 figs.

Erwin, D.N.; Kiel, J.L.; Batishko, C.R.; Stahl, K.A.

1990-08-14T23:59:59.000Z

189

EMSL - image superimposition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

image-superimposition en Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. http:www.emsl.pnl.govemslwebpublicationsmagnesium-behavior-and-structu...

190

image superimposition | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

superimposition image superimposition Leads No leads are available at this time. Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. Abstract: As a...

191

Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration  

E-Print Network [OSTI]

received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

Gelman, Andrew

192

Edge-based correlation image registration for multispectral imaging  

DOE Patents [OSTI]

Registration information for images of a common target obtained from a plurality of different spectral bands can be obtained by combining edge detection and phase correlation. The images are edge-filtered, and pairs of the edge-filtered images are then phase correlated to produce phase correlation images. The registration information can be determined based on these phase correlation images.

Nandy, Prabal (Albuquerque, NM)

2009-11-17T23:59:59.000Z

193

Visual Speech Recognition Using Image Moments and Multiresolution Wavelet Images  

Science Journals Connector (OSTI)

This paper describes a new technique for recognizing speech using visual speech information. The video data of the speaker's mouth is represented using grayscale images named as motion history image (MHI). MHI is generated by applying accumulative image ... Keywords: visual speech recognition, motion history image, image moments, discrete stationary wavelet transform

Wai C. Yau; Dinesh K. Kumar; Sridhar P. Arjunan; Sanjay Kumar

2006-07-01T23:59:59.000Z

194

A CMOS contact imager for locating individual Honghao Ji, David Sander, Alfred Haas, Pamela A. Abshire  

E-Print Network [OSTI]

to the background illumination. The imager is capable of locating dark objects in a bright background or bright objects in a dark background. The loca- tions of recognized cells are generated as outputs to alleviate of intracel- lular processes, drug development, medical diagnostics, and the development of cell-based sensors

Maryland at College Park, University of

195

Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy  

E-Print Network [OSTI]

Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy.

Charles Sanson; Odile Diou; Julie Thevenot; Emmanuel Ibarboure; Alain Soum; Annie Brûlet; Sylvain Miraux; Eric Thiaudière; Sisareuth Tan; Alain Brisson; Vincent Dupuis; Olivier Sandre; Sébastien Lecommandoux

2012-09-23T23:59:59.000Z

196

A review of age-old antimalarial drug to combat malaria: efficacy up-gradation by nanotechnology based drug delivery  

Science Journals Connector (OSTI)

Abstract Malaria is uncontrolled burden in the world till now. Despite of different efforts to develop antimalarial drug for decades, any anti-malarial drug can able to eradicate completely till now. Many anti-malarial substances are practically ineffectual because of their physicochemical limitations, cytotoxicity, chemical instability and degradation, and limited activities against intracellular parasites. Taking into consideration, the amount of research is going to conduct in the field of nanoparticle based drug delivery systems, lead to new ways of improving the treatment of infectious diseases. The study has focused on the progress and advancement of research on nanotechnology based drug delivery to eradicate the malaria. We like to focus the efficacy of nanotechnology based drug application for the opening out of novel chemotherapeutics in laboratory research, which may show the way to better use with age-old antimalarial drug and may draw the attention of pharmaceutical industries for the improvement and designing of effective anti-malarial drugs in future.

Satyajit Tripathy; Somenath Roy

2014-01-01T23:59:59.000Z

197

Molecular mechanism of an adverse drug–drug interaction of allopurinol and furosemide in gout treatment  

Science Journals Connector (OSTI)

Abstract Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of gout patients is based on two further complementary mechanisms, the direct inhibition of XO activity by the allopurinol metabolite oxypurinol and a down-regulation of XO protein expression. The latter is compromised by addition of furosemide and might explain why patients receiving furosemide therapy require higher allopurinol doses. miR-448 was identified as a potential drug-dependent XO regulator. Finally, down-regulation of AMPK protein expression in HRCE cells by administration of oxypurinol/furosemide reveals a possible new mechanism of renal drug-induced hyperuricemia.

Claudia Knake; Lisa Stamp; Andrew Bahn

2014-01-01T23:59:59.000Z

198

Directional Multiresolution Image Representations  

E-Print Network [OSTI]

) are not necessarily best suited for images. Thus, there is a strong motivation to search for more powerful schemes consid´er´ees comme de bonnes repr´esentations des images na- turelles. Le lien entre les courbelettes et

Do, Minh N.

199

Medical imaging systems  

DOE Patents [OSTI]

A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

Frangioni, John V. (Wayland, MA)

2012-07-24T23:59:59.000Z

200

DOUBLE MAJORS Imaging Science + ...  

E-Print Network [OSTI]

DOUBLE MAJORS Imaging Science + ... Applied Mathematics Biomedical Sciences Computer Science Undergraduate Research Internships and Cooperative Education (Co-op) (optional) Study Abroad WHY IMAGING SCIENCE Science: BS, MS, PhD Color Science: MS, PhD BS + MS/PhD Combos HUMAN VISION BIO- MEDICAL ASTRO- PHYSICS

Zanibbi, Richard

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Heart imaging method  

DOE Patents [OSTI]

A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.

Collins, H. Dale (Richland, WA); Gribble, R. Parks (Richland, WA); Busse, Lawrence J. (Littleton, CO)

1991-01-01T23:59:59.000Z

202

Seismic image waves  

Science Journals Connector (OSTI)

......involved in the seismic imaging process, for example the migration...revisited, 60th Ann. Int. Mtg., Soc. Expl. Geophys...involved in the seismic imaging process, for example the migration...revisited, 60th Ann. Int. Mtg., SOC. Expl. Geophys......

Peter Hubral; Martin Tygel; Jörg Schleicher

1996-05-01T23:59:59.000Z

203

Adaptive wiener image restoration kernel  

DOE Patents [OSTI]

A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

Yuan, Ding (Henderson, NV)

2007-06-05T23:59:59.000Z

204

User Science Images  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

User Science Images User Science Images User Science Images Sort by: Default | Name | Date (low-high) | Date (high-low) | Category NIMROD-1.png FES: NIMROD Simulation February 18, 2010 | Author(s): Dr. Charlson C. Kim (University of Washington) | Category: Fusion Energy | URL: https://nimrodteam.org/ Download Image: NIMROD-1.png | png | 1.5 MB Trajectory of an energetic ion in a Field Reverse Configuration (FRC) magnetic field. Magnetic separatrix denoted by green surface. Spheres are colored by azimuthal velocity. Image courtesy of Charlson Kim, University of Washington; NERSC repos m487, mp21, m1552 Scheibe.png BER: Pore-Scale Fluid Flow for Subsurface Reactive Transport January 1, 2008 | Author(s): Timothy D. Scheibe, PNNL | Category: Environmental Science | URL: http://http://subsurface.pnl.gov/

205

Manhattan Project: Image Retouching`  

Office of Scientific and Technical Information (OSTI)

Image Retouching Image Retouching Resources > Photo Gallery Smyth Report (original) Smyth Report (retouched) Images on this web site have sometimes been "retouched." In every case, however, the intention has been only to restore the image as much as possible to its original condition. Above is a rather extreme example-"before and after" versions of the cover of the Smyth Report (Henry DeWolf Smyth, Atomic Energy for Military Purposes: The Official Report on the Development of the Atomic Bomb under the Auspices of the United States Government, 1940-1945 (Princeton, NJ: Princeton University Press, 1945)). The Smyth Report was commissioned by Leslie Groves and originally issued by the Manhattan Engineer District. Princeton University Press reprinted it in book form as a "public service" with "reproduction in whole or in part authorized and permitted.") Larger versions of the same images are below.

206

GTL Image Gallery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Genome Project Information • Genomic Science • Microbial Genome Program • sitemap • home Human Genome Project Information • Genomic Science • Microbial Genome Program • sitemap • home Announcing the New Image Gallery Visit the new Image Gallery for an expanded suite of images Biofuels Browse the 2010 "Bioenergy Research Centers: An Overview of the Science" Brochure Gallery. Browse the 2006 "Breaking the Biological Barriers to Cellulosic Ethanol: A Joint Research Agenda" Report Gallery. Browse more biofuels images (includes the June 2006 "Understanding Biomass" Primer Gallery). Systems Biology Browse the August 2005 "Genomics:GTL Roadmap: Systems Biology for Energy and Environment" Gallery. Basic Genomics Browse the Human Chromosome Gallery. Browse more Basic Genomics images. Carbon Cycling

207

Time encoded radiation imaging  

DOE Patents [OSTI]

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21T23:59:59.000Z

208

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors  

Science Journals Connector (OSTI)

...mum of tissue, using a 543 excitation laser and LP 560 emission filter. A plane approximately...to local tumors can be thought of as the fusion of 2 traditional approaches to drug delivery...Ther 2010;9:1798-808. 11. Dvorak HF , Nagy JA, Dvorak JT Dvorak AM.Identification...

Ashley A. Manzoor; Lars H. Lindner; Chelsea D. Landon; Ji-Young Park; Andrew J. Simnick; Matthew R. Dreher; Shiva Das; Gabi Hanna; Won Park; Ashutosh Chilkoti; Gerben A. Koning; Timo L.M. ten Hagen; David Needham; and Mark W. Dewhirst

2012-11-01T23:59:59.000Z

209

1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds  

E-Print Network [OSTI]

proteins including enzymes, ion channels, GPCRs and nuclear receptors. However, current drug and nuclear receptors [5]. Publicly available databases have been built and maintained, such as KEGG BRITE [6 using chemical and interaction information about known compounds in the dataset. The WNN method can

Marchiori, Elena

210

Quantitative Selected Ion Monitoring (QSIM) of Drugs and/or Drug Metabolites in Biological Matrices  

Science Journals Connector (OSTI)

......continued. Substance Thiothixene Haloperidol Lithium Trazodone Hormones Testosterone 5n...Table I were chosen based on ease of synthesis. The one exception was amitriptyline-d6...deactivated by injecting aliquots of an ethyl acetate extract of a drug-free matrix. Aliquots......

W.A. Garland; M.L. Powell

1981-08-01T23:59:59.000Z

211

Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery  

E-Print Network [OSTI]

Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

Bagby, Taryn Rochelle

2011-12-31T23:59:59.000Z

212

Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells  

Science Journals Connector (OSTI)

...ICR's basic science and have invested heavily in high-throughput screening robotics, crystallography, and high-performance computing for integrative genomics and chemobiology. Crucially, we're all under one roof, co-located with the...

Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T.C. Wong

2010-10-01T23:59:59.000Z

213

Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery  

E-Print Network [OSTI]

M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

Ghosh, Debadyuti

214

Radiotracer Chemistry and Instrumentation for Biological Imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Addiction Research at Brookhaven Addiction Research at Brookhaven History: In 1987, Brookhaven National Laboratory became the first research institution to use positron emission tomography (PET) and other medical imaging techniques to investigate the brain mechanisms underlying drug addiction. Addiction Research Press Releases brain volume Drinking Alcohol Shrinks Critical Brain Regions in Genetically Vulnerable Mice - 2/15/2012 Brain scans of two strains of mice imbibing significant quantities of alcohol reveal serious shrinkage in some brain regions - but only in mice lacking a particular type of receptor for dopamine, the brain's "reward" chemical. brain scan Gray Matter in Brain's Control Center Linked to Ability to Process Reward - 11/29/2011 Study is first to show link between structure and function in healthy people, and the impairment of both structure and function in people addicted to cocaine.

215

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 |  

Broader source: Energy.gov (indexed) [DOE]

Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 Matrix, Drug Testing for DOE Security Clearance - September 1, 2011 September 1, 2011 The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance. A current test is one taken within 60 calendar days of the individual's SF-86/SF-86C signature date. For those cases where no such form is collected (e.g. reciprocity) the test must have been taken within 60 calendar days of the date of the request for security clearance. Matrix, Drug Testing for DOE security clearance - September 1, 2011

216

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Broader source: Energy.gov (indexed) [DOE]

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

217

DOE Laboratories Help Develop Promising New Cancer Fighting Drug,  

Broader source: Energy.gov (indexed) [DOE]

Laboratories Help Develop Promising New Cancer Fighting Drug, Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm Addthis Powerful X-Rays Enable Development of Successful Treatment for Melanoma and Other Life-Threatening Diseases WASHINGTON, DC - Powerful X-ray technology developed at the U.S. Department of Energy's (DOE's) national laboratories is revealing new insights into diseases ranging from Alzheimer's to the swine flu, and, most recently, enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), received Food and Drug Administration (FDA) approval on Wednesday. In showing the structures of diseased and

218

Polarization transfer NMR imaging  

DOE Patents [OSTI]

A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.

Sillerud, Laurel O. (Los Alamos, NM); van Hulsteyn, David B. (Santa Fe, NM)

1990-01-01T23:59:59.000Z

219

Quantum ghost imaging through turbulence  

SciTech Connect (OSTI)

We investigate the effect of turbulence on quantum ghost imaging. We use entangled photons and demonstrate that for a specific experimental configuration the effect of turbulence can be greatly diminished. By decoupling the entangled photon source from the ghost-imaging central image plane, we are able to dramatically increase the ghost-image quality. When imaging a test pattern through turbulence, this method increases the imaged pattern visibility from V=0.15{+-}0.04 to 0.42{+-}0.04.

Dixon, P. Ben; Howland, Gregory A.; Howell, John C. [Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627 (United States); Chan, Kam Wai Clifford [Rochester Optical Manufacturing Company, Rochester, New York 14606 (United States); O'Sullivan-Hale, Colin; Rodenburg, Brandon [Institute of Optics, University of Rochester, Rochester, New York 14627 (United States); Hardy, Nicholas D.; Shapiro, Jeffrey H. [Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Simon, D. S.; Sergienko, A. V. [Department of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215 (United States); Boyd, R. W. [Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627 (United States); Institute of Optics, University of Rochester, Rochester, New York 14627 (United States)

2011-05-15T23:59:59.000Z

220

Scanning computed confocal imager  

DOE Patents [OSTI]

There is provided a confocal imager comprising a light source emitting a light, with a light modulator in optical communication with the light source for varying the spatial and temporal pattern of the light. A beam splitter receives the scanned light and direct the scanned light onto a target and pass light reflected from the target to a video capturing device for receiving the reflected light and transferring a digital image of the reflected light to a computer for creating a virtual aperture and outputting the digital image. In a transmissive mode of operation the invention omits the beam splitter means and captures light passed through the target.

George, John S. (Los Alamos, NM)

2000-03-14T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Metamaterial microwave holographic imaging system  

Science Journals Connector (OSTI)

We demonstrate a microwave imaging system that combines advances in metamaterial aperture design with emerging computational imaging techniques. The flexibility inherent to...

Hunt, John; Gollub, Jonah; Driscoll, Tom; Lipworth, Guy; Mrozack, Alex; Reynolds, Matthew S; Brady, David J; Smith, David R

2014-01-01T23:59:59.000Z

222

Matrix, Drug Testing for DOE Security Clearance- September 1, 2011  

Broader source: Energy.gov [DOE]

The following matrix identifies those individuals required to have a current negative drug test as a prerequisite for being processed for a security clearance

223

Unlocking enzyme synthesis of rare sugars to create drugs with...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

this study is to dramatically improve the performance of enzymes that can be used by the pharmaceutical industry to synthesize drug precursors," said ORNL's Andrey Kovalevsky, the...

224

In silico modeling to predict drug-induced phospholipidosis  

SciTech Connect (OSTI)

Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structure–activity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 80–81% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: • New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. • The training set data in the models is derived from the FDA's phospholipidosis database. • We find excellent predictivity values of the models based on external validation. • The models can support drug screening and regulatory decision-making on DIPL.

Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

2013-06-01T23:59:59.000Z

225

Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment  

E-Print Network [OSTI]

Bulletin of Mathematical Biology (2007). DOI 10.1007/s11538-007-9203-3. ORIGINAL ARTICLE. Emergence of HIV-1 Drug Resistance During Antiretroviral.

2007-08-22T23:59:59.000Z

226

Emergence of drug resistance - Department of Mathematics, Purdue ...  

E-Print Network [OSTI]

Emergence of drug resistance: implications for antiviral control of pandemic influenza. Murray E. Alexander. 1. , Christopher S. Bowman. 1. , Zhilan Feng. 2.

2007-08-22T23:59:59.000Z

227

Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs  

Science Journals Connector (OSTI)

Abstract Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers.

M. Howell; J. Mallela; C. Wang; S. Ravi; S. Dixit; U. Garapati; S. Mohapatra

2013-01-01T23:59:59.000Z

228

Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture  

DOE Patents [OSTI]

Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates.

Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S.

2013-01-08T23:59:59.000Z

229

Manhattan Project: People Images  

Office of Scientific and Technical Information (OSTI)

PEOPLE IMAGES PEOPLE IMAGES Resources > Photo Gallery Scroll down to see each of these images individually. The images are: 1. J. Robert Oppenheimer, Enrico Fermi, and Ernest Lawrence (courtesy the Lawrence Berkeley National Laboratory); 2. Hanford, Washington, workers sending money home (reproduced from the photo insert in F. G. Gosling, The Manhattan Project: Making the Atomic Bomb (Washington: History Division, Department of Energy, October 2001)); 3. Oppenheimer and Leslie Groves at the Trinity Site, September 1945 (reproduced from the cover of the Office of History and Heritage Resources publication: The Signature Facilities of the Manhattan Project (Washington: History Division, Department of Energy, 2001)); 4. A WAC detachment marching at Oak Ridge, Tennessee, June 1945 (courtesy the Army Corps of Engineers; it is reprinted in Rachel Fermi and Esther Samra, Picturing the Bomb: Photographs from the Secret World of the Manhattan Project (New York: Harry N. Abrams, Inc., Publishers, 1995), 40);

230

Manhattan Project: Science Images  

Office of Scientific and Technical Information (OSTI)

SCIENCE IMAGES SCIENCE IMAGES Resources > Photo Gallery Scroll down to see each of these images individually. The images are: 1. Fission (this graphic is adapted from a graphic originally produced by the Washington State Department of Health; the modifications are original to the History Division, now Office of History and Heritage Resources, 2003); 2. Fat Man (plutonium bomb), August 1945 (courtesy the U.S. Army Corps of Engineers (via theNational Archives)); 3. F Reactor Plutonium Production Complex Hanford, Washington, 1945; 4. A Cockroft-Walton machine at Los Alamos, New Mexico (courtesy the Los Alamos National Laboratory; it is reprinted in John F. Hogerton, ed., "Cockroft-Walton Machine," The Atomic Energy Deskbook (New York: Reinhold Publishing Corporation, 1963, prepared under the auspices of the Division of Technical Information, U.S. Atomic Energy Commission), 102);

231

Practical image based lighting  

E-Print Network [OSTI]

In this thesis, we present a user-friendly and practical method for seamless integration of computer-generated images (CG) with real photographs and video. In general such seamless integration is extremely hard and requires recovery of real world...

Lee, Jaemin

2012-06-07T23:59:59.000Z

232

Photothermal imaging scanning microscopy  

DOE Patents [OSTI]

Photothermal Imaging Scanning Microscopy produces a rapid, thermal-based, non-destructive characterization apparatus. Also, a photothermal characterization method of surface and subsurface features includes micron and nanoscale spatial resolution of meter-sized optical materials.

Chinn, Diane (Pleasanton, CA); Stolz, Christopher J. (Lathrop, CA); Wu, Zhouling (Pleasanton, CA); Huber, Robert (Discovery Bay, CA); Weinzapfel, Carolyn (Tracy, CA)

2006-07-11T23:59:59.000Z

233

Overview of Image Reconstruction  

SciTech Connect (OSTI)

Image reconstruction (or computerized tomography, etc.) is any process whereby a function, f, on Rn is estimated from empirical data pertaining to its integrals, ∫f(x) dx, for some collection of hyperplanes of dimension k < n. The paper begins with background information on how image reconstruction problems have arisen in practice, and describes some of the application areas of past or current interest; these include radioastronomy, optics, radiology and nuclear medicine, electron microscopy, acoustical imaging, geophysical tomography, nondestructive testing, and NMR zeugmatography. Then the various reconstruction algorithms are discussed in five classes: summation, or simple back-projection; convolution, or filtered back-projection; Fourier and other functional transforms; orthogonal function series expansion; and iterative methods. Certain more technical mathematical aspects of image reconstruction are considered from the standpoint of uniqueness, consistency, and stability of solution. The paper concludes by presenting certain open problems. 73 references. (RWR)

Marr, R.B.

1980-04-01T23:59:59.000Z

234

Image Content Engine (ICE)  

SciTech Connect (OSTI)

The Image Content Engine (ICE) is being developed to provide cueing assistance to human image analysts faced with increasingly large and intractable amounts of image data. The ICE architecture includes user configurable feature extraction pipelines which produce intermediate feature vector and match surface files which can then be accessed by interactive relational queries. Application of the feature extraction algorithms to large collections of images may be extremely time consuming and is launched as a batch job on a Linux cluster. The query interface accesses only the intermediate files and returns candidate hits nearly instantaneously. Queries may be posed for individual objects or collections. The query interface prompts the user for feedback, and applies relevance feedback algorithms to revise the feature vector weighting and focus on relevant search results. Examples of feature extraction and both model-based and search-by-example queries are presented.

Brase, J M

2007-03-26T23:59:59.000Z

235

JOB OPPORTUNITIES Breast imaging  

E-Print Network [OSTI]

Genitourinary Radiology Head and Neck Radiology Musculoskeletal Radiology Neuroradiology Pediatric RadiologyJOB OPPORTUNITIES Breast imaging Chest Radiology Emergency Radiology Gastrointestinal Radiology Interventional Radiology Nuclear Radiology Radiation Oncology What Can I Do With a Major in... Radiological

Jiang, Huiqiang

236

THERMAL NEUTRON BACKSCATTER IMAGING.  

SciTech Connect (OSTI)

Objects of various shapes, with some appreciable hydrogen content, were exposed to fast neutrons from a pulsed D-T generator, resulting in a partially-moderated spectrum of backscattered neutrons. The thermal component of the backscatter was used to form images of the objects by means of a coded aperture thermal neutron imaging system. Timing signals from the neutron generator were used to gate the detection system so as to record only events consistent with thermal neutrons traveling the distance between the target and the detector. It was shown that this time-of-flight method provided a significant improvement in image contrast compared to counting all events detected by the position-sensitive {sup 3}He proportional chamber used in the imager. The technique may have application in the detection and shape-determination of land mines, particularly non-metallic types.

VANIER,P.; FORMAN,L.; HUNTER,S.; HARRIS,E.; SMITH,G.

2004-10-16T23:59:59.000Z

237

Combined Illumination Cylindrical Millimeter-Wave Imaging Technique for Concealed Weapon Detection  

SciTech Connect (OSTI)

A novel millimeter-wave imaging technique has been developed for personnel surveillance applications, including the detection of concealed weapons, explosives, drugs, and other contraband material. Millimeter-waves are high-frequency radio waves in the frequency band of 30-300 GHz, and pose no health threat to humans at moderate power levels. These waves readily penetrate common clothing materials, and are reflected by the human body and by concealed items. The combined illumination cylindrical imaging concept consists of a vertical, high-resolution, millimeter-wave array of antennas which is scanned in a cylindrical manner about the person under surveillance. Using a computer, the data from this scan is mathematically reconstructed into a series of focused 3-D images of the person. After reconstruction, the images are combined into a single high-resolution three-dimensional image of the person under surveillance. This combined image is then rendered using 3-D computer graphics techniques. The combined cylindrical illumination is critical as it allows the display of information from all angles. This is necessary because millimeter-waves do not penetrate the body. Ultimately, the images displayed to the operator will be icon-based to protect the privacy of the person being screened. Novel aspects of this technique include the cylindrical scanning concept and the image reconstruction algorithm, which was developed specifically for this imaging system. An engineering prototype based on this cylindrical imaging technique has been fabricated and tested. This work has been sponsored by the Federal Aviation Administration (FAA).

Sheen, David M.; McMakin, Douglas L.; Hall, Thomas E.

2000-04-01T23:59:59.000Z

238

Ethics and Drug-Free Certification Form  

Broader source: Energy.gov (indexed) [DOE]

NEW EMPLOYEE ORIENTATION NEW EMPLOYEE ORIENTATION ETHICS BRIEFING CERTIFICATION OF ______________________________ (Print Name) I hereby certify that I have reviewed the New Employee Orientation information on the Standards of Ethical Conduct for Employees in the Executive Branch, 5 C.F. R. Part 2635, and the DOE 3792.3 Drug-Free Federal Workplace Testing Program. Further, I certify that I understand that all Department of Energy employees, other than Special Government Employees, must obtain prior written approval from their immediate supervisor and an ethics counselor prior to engaging in outside activities, regardless of whether those activities are compensated. I understand that this requirement includes approval of any activities in which I am engaged upon entering Federal

239

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance  

E-Print Network [OSTI]

Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

Hanson, Floyd B.

240

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine  

Science Journals Connector (OSTI)

......dismantled to extract the drug for abuse, propylhexedrine became the...the decedent's computer and internet usage history indicated he had...Online , and CEDIA for drugs of abuse. A full-scan (m/z 42550...propylhexedrine (Benzedrex ) abuse and sudden death. Am. J......

Justin M. Holler; Shawn P. Vorce; Pamela C. McDonough-Bender; Joseph Magluilo; Jr.; Carol J. Solomon; Barry Levine

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Polysaccharide-based aerogel microspheres for oral drug delivery  

Science Journals Connector (OSTI)

Abstract Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10?3 and 1.7 × 10?3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher-Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min?1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.

C.A. García-González; M. Jin; J. Gerth; C. Alvarez-Lorenzo; I. Smirnova

2014-01-01T23:59:59.000Z

242

Division of Human Resources Alcohol & Drug Testing (CDL)  

E-Print Network [OSTI]

Division of Human Resources Alcohol & Drug Testing (CDL) Summary of Program Responsibilities Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 · Report for duty for eight hours following an accident or until undergoing a post-accident test. · Report for duty or remain

Meyers, Steven D.

243

Division of Human Resources Alcohol & Drug Testing for  

E-Print Network [OSTI]

Division of Human Resources Alcohol & Drug Testing for Jobs Requiring CDL Employee Relations/Alcohol & Drug Testing (CDL) Questions: (813) 974-2970 Rev. 12/2008 · Report for duty or remain on duty requiring-accident testing is required, or until he/she undergoes a post-accident alcohol test, whichever occurs first

Meyers, Steven D.

244

Identification of new drug classification terms in textual resources  

Science Journals Connector (OSTI)

......F-score by 14% on the standard DrugBank corpus compared...obtained on the DrugBank standard (89% F-score) and on the Medline standard corpus (83% F-score...classifications. We plan to provide these...One very detailed review especially pinpointed...Evaluation of text mining in biology. In......

Corinna Kolárik; Martin Hofmann-Apitius; Marc Zimmermann; Juliane Fluck

2007-07-01T23:59:59.000Z

245

Drug-Free Federal Workplace Testing Implementation Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

2012-12-06T23:59:59.000Z

246

ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY  

E-Print Network [OSTI]

are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

247

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network [OSTI]

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

248

(WPI-iCeMS) Pure Nano Drugs*  

E-Print Network [OSTI]

(WPI-iCeMS) SN-38 50 nm * Pure Nano Drugs* SN-38 10 HepG2* JST (-STEP Permeation and Retention (EPR)* EPR 20100 nm SN-38 SN-38 * SN-38 * SN-38 20 SN-38 Pure Nano Drugs

Takada, Shoji

249

Quantum Imaging Technologies  

E-Print Network [OSTI]

Over the past three decades, quantum mechanics has allowed the development of technologies that provide unconditionally secure communication. In parallel, the quantum nature of the transverse electromagnetic field has spawned the field of quantum imaging that encompasses technologies such as quantum ghost imaging and high-dimensional quantum key distribution (QKD). The emergence of such quantum technologies also highlights the need for the development of methods for characterizing the elusive quantum state itself. In this document, we describe new technologies that use the quantum properties of light for security. The first is a technique that extends the principles behind QKD to the field of imaging. By applying the polarization-based BB84 protocol to individual photons in an active imaging system, we obtained images that are secure against intercept-resend jamming attacks. The second technology presented in this article is based on an extension of quantum ghost imaging. We used a holographic filtering technique to build a quantum ghost image identification system that uses a few pairs of photons to identify an object from a set of known objects. The third technology addressed in this document is a high-dimensional QKD system that uses orbital-angular-momentum (OAM) modes of light for encoding. Moving to a high-dimensional state space in QKD allows one to impress more information on each photon, as well as introduce higher levels of security. We discuss the development of two OAM-QKD protocols based on the BB84 and Ekert QKD protocols. The fourth and final technology presented in this article is a relatively new technique called direct measurement that uses sequential weak and strong measurements to characterize a quantum state. We use this technique to characterize the quantum state of a photon with a dimensionality of d=27, and measure its rotation in the natural basis of OAM.

Mehul Malik; Robert W. Boyd

2014-06-06T23:59:59.000Z

250

Manhattan Project: Events Images  

Office of Scientific and Technical Information (OSTI)

Resources Resources About this Site How to Navigate this Site Library Maps Note on Sources Nuclear Energy and the Public's Right to Know Photo Gallery Site Map Sources and Notes Suggested Readings EVENTS IMAGES Resources > Photo Gallery Page Content Here Scroll down to see each of these images individually. The images are: 1. Albert Einstein and Leo Szilard (courtesy the Federation of American Scientists); 2. Painting of CP-1 going critical (courtesy the National Archives); 3. An Alpha Racetrack inside the Y-12 Electromagnetic Plant, Clinton Engineer Works, Oak Ridge, Tennessee; 4. Eric Jette, Charles Critchfield, and J. Robert Oppenheimer, Los Alamos, New Mexico (this photograph is reprinted from Los Alamos Scientific Laboratory, Los Alamos: Beginning of an Era, 1943-1945 (Los Alamos: Public Relations Office, Los Alamos Scientific Laboratory, ca. 1967-1971), 20);

251

Multispectral imaging probe  

DOE Patents [OSTI]

A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector. 8 figs.

Sandison, D.R.; Platzbecker, M.R.; Descour, M.R.; Armour, D.L.; Craig, M.J.; Richards-Kortum, R.

1999-07-27T23:59:59.000Z

252

Multispectral imaging probe  

DOE Patents [OSTI]

A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector.

Sandison, David R. (Moriarty, NM); Platzbecker, Mark R. (Albuquerque, NM); Descour, Michael R. (Tucson, AZ); Armour, David L. (Albuquerque, NM); Craig, Marcus J. (Albuquerque, NM); Richards-Kortum, Rebecca (Austin, TX)

1999-01-01T23:59:59.000Z

253

Variable waveband infrared imager  

DOE Patents [OSTI]

A waveband imager includes an imaging pixel that utilizes photon tunneling with a thermally actuated bimorph structure to convert infrared radiation to visible radiation. Infrared radiation passes through a transparent substrate and is absorbed by a bimorph structure formed with a pixel plate. The absorption generates heat which deflects the bimorph structure and pixel plate towards the substrate and into an evanescent electric field generated by light propagating through the substrate. Penetration of the bimorph structure and pixel plate into the evanescent electric field allows a portion of the visible wavelengths propagating through the substrate to tunnel through the substrate, bimorph structure, and/or pixel plate as visible radiation that is proportional to the intensity of the incident infrared radiation. This converted visible radiation may be superimposed over visible wavelengths passed through the imaging pixel.

Hunter, Scott R.

2013-06-11T23:59:59.000Z

254

Modern Imaging Technology: Recent Advances  

SciTech Connect (OSTI)

This 2-day conference is designed to bring scientist working in nuclear medicine, as well as nuclear medicine practitioners together to discuss the advances in four selected areas of imaging: Biochemical Parameters using Small Animal Imaging, Developments in Small Animal PET Imaging, Cell Labeling, and Imaging Angiogenesis Using Multiple Modality. The presentations will be on molecular imaging applications at the forefront of research, up to date on the status of molecular imaging in nuclear medicine as well as in related imaging areas. Experts will discuss the basic science of imaging techniques, and scheduled participants will engage in an exciting program that emphasizes the current status of molecular imaging as well as the role of DOE funded research in this area.

Welch, Michael J.; Eckelman, William C.

2004-06-18T23:59:59.000Z

255

Fact Sheet on the Consequences of a Positive Drug Test | Department...  

Office of Environmental Management (EM)

Fact Sheet on the Consequences of a Positive Drug Test Fact Sheet on the Consequences of a Positive Drug Test FACT SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary...

256

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...EXPERIMENTAL THERAPEUTICS Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs...India We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs...histopathology, suggesting that the nanoparticle drug delivery system has potential...

Christine M. Johnson; Rajesh Pandey; Sadhna Sharma; G. K. Khuller; Randall J. Basaraba; Ian M. Orme; Anne J. Lenaerts

2005-10-01T23:59:59.000Z

257

Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine.  

Science Journals Connector (OSTI)

...that of placebo. Recovery of drug-resistant...for Microbiology Recovery of Drug-Resistant...Oklahoma 731063; and National Institute for Medical...documented the recovery of drug- resistant...respective institutional review boards ofthe participating...

F G Hayden; S J Sperber; R B Belshe; R D Clover; A J Hay; S Pyke

1991-09-01T23:59:59.000Z

258

An emerging platform for drug delivery: Aerogel based systems  

Science Journals Connector (OSTI)

Abstract Over the past few decades, advances in “aerogel science” have provoked an increasing interest for these materials in pharmaceutical sciences for drug delivery applications. Because of their high surface areas, high porosities and open pore structures which can be tuned and controlled by manipulation of synthesis conditions, nanostructured aerogels represent a promising class of materials for delivery of various drugs as well as enzymes and proteins. Along with biocompatible inorganic aerogels and biodegradable organic aerogels, more complex systems such as surface functionalized aerogels, composite aerogels and layered aerogels have also been under development and possess huge potential. Emphasis is given to the details of the aerogel synthesis and drug loading methods as well as the influence of synthesis parameters and loading methods on the adsorption and release of the drugs. Owing to their ability to increase the bioavailability of low solubility drugs, to improve both their stability and their release kinetics, there are an increasing number of research articles concerning aerogels in different drug delivery applications. This review presents an up to date overview of the advances in all kinds of aerogel based drug delivery systems which are currently under investigation.

Zeynep Ulker; Can Erkey

2014-01-01T23:59:59.000Z

259

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis  

SciTech Connect (OSTI)

Isoniazid (INH) is a frontline antitubercular drug that inhibits the enoyl acyl carrier protein reductase InhA. Novel inhibitors of InhA that are not cross-resistant to INH represent a significant goal in antitubercular chemotherapy. The design, synthesis, and biological activity of a series of triclosan-based inhibitors is reported, including their promising efficacy against INH-resistant strains of M. tuberculosis. Triclosan has been previously shown to inhibit InhA, an essential enoyl acyl carrier protein reductase involved in mycolic acid biosynthesis, the inhibition of which leads to the lysis of Mycobacterium tuberculosis. Using a structure-based drug design approach, a series of 5-substituted triclosan derivatives was developed. Two groups of derivatives with alkyl and aryl substituents, respectively, were identified with dramatically enhanced potency against purified InhA. The most efficacious inhibitor displayed an IC{sub 50} value of 21 nM, which was 50-fold more potent than triclosan. X-ray crystal structures of InhA in complex with four triclosan derivatives revealed the structural basis for the inhibitory activity. Six selected triclosan derivatives were tested against isoniazid-sensitive and resistant strains of M. tuberculosis. Among those, the best inhibitor had an MIC value of 4.7 {mu}g mL{sup -1} (13 {mu}M), which represents a tenfold improvement over the bacteriocidal activity of triclosan. A subset of these triclosan analogues was more potent than isoniazid against two isoniazid-resistant M. tuberculosis strains, demonstrating the significant potential for structure-based design in the development of next generation antitubercular drugs.

Freundlich, Joel S.; Wang, Feng; Vilchèze, Catherine; Gulten, Gulcin; Langley, Robert; Schiehser, Guy A.; Jacobus, David P.; Jacobs, Jr., William R.; Sacchettini, James C.; (Einstein); (TAM); (Jacobus)

2009-06-30T23:59:59.000Z

260

Our Current Approach to Drug Abuse -- Progress, Problems, Proposals  

Science Journals Connector (OSTI)

...treatment settings as appropriate. The intensity of a treatment is often independent of its setting. In addition, systematic research on outcomes is essential to improve the cost effectiveness of treatment and determine what works for whom and why. Such a system would be affordable, could be integrated... Most drug-abuse experts and historians agree that we are in the declining phase of a drug epidemic that began about 30 years ago. Still, drug abuse remains one of the nation's critical domestic problems, linked to crime, neglect of children, family ...

Kleber H.D.

1994-02-03T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Dangerous Deception — Hiding the Evidence of Adverse Drug Effects  

Science Journals Connector (OSTI)

...to address these issues, and payers spend huge sums on the drug, despite the dearth of evidence that it is better than older, cheaper agents. The health care system has a hard time performing drug-safety analyses, in large part because it relies on the pharmaceutical industry to conduct most research... On September 30, the New York Times reported that the FDA had issued a warning that the antifibrinolytic drug aprotinin could cause renal failure, congestive heart failure, stroke, and death. Dr. Jerry Avorn writes that many aspects of the aprotinin saga ...

Avorn J.

2006-11-23T23:59:59.000Z

262

Sources of Regional Variation in Medicare Part D Drug Spending  

Science Journals Connector (OSTI)

...covariates demographic factors (age, sex, and race or ethnic group [black, white, Hispanic, or other]) and socioeconomic characteristics (individual-level Part D LIS status and ZIP Code–level measures of median household income [by quintile] and proportion of the population living in poverty). An indicator... This analysis of 2008 Medicare data shows that regional variation in drug spending is driven primarily by the use of more expensive drugs (i.e., brand-name rather than generic drugs) in the highest-spending geographic areas.

Donohue J.M.; Morden N.E.; Gellad W.F.

2012-02-09T23:59:59.000Z

263

Image Charge Differential  

E-Print Network [OSTI]

Image Charge Differential Amplifier FT 0 Crude Oil Time (s) 543210 Frequency (kHz) m/z m q B f Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) uses the frequency of cyclotron motion of the ions in a static magnetic field to determine the mass-to-charge ratio, which is then used

Weston, Ken

264

EBSD Images Theoretical Background  

E-Print Network [OSTI]

Motivation EBSD Images Theoretical Background Defects in the Weld Grain Growth Low Speed Welding High Speed Welding Conclusion Heat-Affected Zone Observations Welding Experiments The low density in the transportation industries. Reproducibility and the low cost make welding a major large scale assembly process

Candea, George

265

Time-Encoded Imagers.  

SciTech Connect (OSTI)

This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

Marleau, Peter; Brubaker, Erik

2014-11-01T23:59:59.000Z

266

Image Reconstruction for Prostate Specific Nuclear Medicine imagers  

SciTech Connect (OSTI)

There is increasing interest in the design and construction of nuclear medicine detectors for dedicated prostate imaging. These include detectors designed for imaging the biodistribution of radiopharmaceuticals labeled with single gamma as well as positron-emitting radionuclides. New detectors and acquisition geometries present challenges and opportunities for image reconstruction. In this contribution various strategies for image reconstruction for these special purpose imagers are reviewed. Iterative statistical algorithms provide a framework for reconstructing prostate images from a wide variety of detectors and acquisition geometries for PET and SPECT. The key to their success is modeling the physics of photon transport and data acquisition and the Poisson statistics of nuclear decay. Analytic image reconstruction methods can be fast and are useful for favorable acquisition geometries. Future perspectives on algorithm development and data analysis for prostate imaging are presented.

Mark Smith

2007-01-11T23:59:59.000Z

267

Devices, systems, and methods for imaging  

DOE Patents [OSTI]

Certain exemplary embodiments comprise a system, which can comprise an imaging plate. The imaging plate can be exposable by an x-ray source. The imaging plate can be configured to be used in digital radiographic imaging. The imaging plate can comprise a phosphor-based image storage device configured to convert an image stored therein into light.

Appleby, David (North Garden, VA); Fraser, Iain (Ruckersville, VA); Watson, Scott (Jemez Springs, NM)

2008-04-15T23:59:59.000Z

268

E-Print Network 3.0 - age-related drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as improving symptom control... , London NW1 2BE. HIGHLIGHT Zebrafish as a drug screening platform ENABLING TECHNOLOGIES, PRODUCTS... of zebrafish to facilitate drug discovery....

269

E-Print Network 3.0 - antimalarial drug artemisinin Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug... artemisinin as the lead drug, using Partial Least Squares (PLS) regression. Methodology: All biological data... LQTA-QSAR ANALYSIS OF A SET OF ANTIMALARIAL COMPOUNDS...

270

E-Print Network 3.0 - antithyroid drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science 57 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

271

E-Print Network 3.0 - acute cutaneous drug Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Dundee Collection: Biology and Medicine 72 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: -inflammatory drugs are often...

272

E-Print Network 3.0 - alternative drug interaction Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mathematics 69 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

273

E-Print Network 3.0 - assessing drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mathematics 28 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

274

E-Print Network 3.0 - avoiding drug development Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

diseases. To maximize drug viability and profit, one... development for use in the pharmaceutical industry in helping to determine viability of drugs... on the field of...

275

E-Print Network 3.0 - advanced drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to this problem could be from rational drug design using Bioinformatics. The focus of the pharmaceutical industry... design. A successful and reliable drug design process could...

276

E-Print Network 3.0 - antipsychotic drug ykp1358 Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Idle, J.R. (1997). Antipsychotic drug-induced movement disorders... Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

277

E-Print Network 3.0 - active drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Delivery, Bionanotechnology and Molecular Recognition, Departments... 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

278

E-Print Network 3.0 - anticancer drug analysis Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

products, can have antibiotic, anticancer, anticholesterolemic... , and other activities that make them useful as drugs or drug leads for the treatment ... Source: New...

279

E-Print Network 3.0 - artery disease drugs Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Plan Benefit Guide Revised 101510 Summary: artery disease or congestive heart failure) are eligible for the Value-Based Prescription Drug Plan... (Coronary Artery...

280

E-Print Network 3.0 - antirheumatic drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

elderly: Pharmacy data as a tool for improvement Summary: Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997... for Drug...

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

E-Print Network 3.0 - amplifies stent-based drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

282

E-Print Network 3.0 - antimalarial drug discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

283

E-Print Network 3.0 - antimicrobial drug discovery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

assessment for antiparasitic drug discovery Julie A. Frearson, Paul... G. Wyatt, Ian H. Gilbert and Alan H. Fairlamb Drug Discovery Unit, College of Life Sciences... , University...

284

E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

285

E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

286

E-Print Network 3.0 - antiinflammatory drug chemistry Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug chemistry Search Powered by Explorit Topic List Advanced Search Sample search results for: antiinflammatory drug chemistry Page: << < 1 2 3 4 5 > >> 1 Novel Anti-Inflammatory...

287

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

288

Modeling within-host HIV-1 dynamics and the evolution of drug ...  

E-Print Network [OSTI]

Apr 19, 2007 ... of drug resistance: Trade-offs between viral enzyme function and drug susceptibility. Libin Ronga, Michael A. Gilchristb, Zhilan Fenga, Alan S.

2007-08-22T23:59:59.000Z

289

E-Print Network 3.0 - acquired drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug resistance, especially if the focus of the analysis... 2010 pp. 905-918 AN ELEMENTARY APPROACH TO MODELING DRUG RESISTANCE IN CANCER Cristian Tomasetti... the problem of...

290

E-Print Network 3.0 - antiretroviral drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

291

E-Print Network 3.0 - antiretroviral drug failure Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

292

E-Print Network 3.0 - antiretroviral drug exposure Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... , antiretroviral therapies, drug resistance, mathematical model,...

293

Image Utility Assessment and a Relationship with Image Quality Assessment  

E-Print Network [OSTI]

Image Utility Assessment and a Relationship with Image Quality Assessment David M. Rouse , Romuald information to humans, and this paper investigates the utility assessment task, where human observers evaluate the usefulness of a natural image as a surrogate for a reference. Current QA algorithms implicitly assess utility

Hemami, Sheila S.

294

Comprehensive Study of Image Restoration Algorithms.  

E-Print Network [OSTI]

??Abstract Comprehensive Study of Image Restoration Algorithms By Lize Zong Master of Science in Electrical Engineering Image restoration is an important part of digital image-processing.… (more)

Zong, Lize

2015-01-01T23:59:59.000Z

295

Fundamentals of Medical Image Processing  

Science Journals Connector (OSTI)

After some remarks to the background and terminology used, Sect. 62.3 deals with low-level image processing as far as necessary to understand the following chapters. Subsequently, the core steps of image analy...

Thomas M. Deserno

2011-01-01T23:59:59.000Z

296

Image-based building modeling.  

E-Print Network [OSTI]

??Image-based modeling is the process of converting 2D images of the real world into digital 3D models in computer. Among myriad kinds of objects in… (more)

Xiao, Jianxiong

2009-01-01T23:59:59.000Z

297

Total Sky Imager (TSI) Handbook  

SciTech Connect (OSTI)

The total sky imager (TSI) provides time series of hemispheric sky images during daylight hours and retrievals of fractional sky cover for periods when the solar elevation is greater than 10 degrees.

Morris, VR

2005-06-01T23:59:59.000Z

298

Ultrasonic Maximum Aperture Saft Imaging  

Science Journals Connector (OSTI)

The focused transducer combined with C-scan imaging is currently the workhorse of ultrasonic nondestructive evaluation (NDE) [1]. Its strength lies in its simplicity and high quality images. There is room for imp...

P. J. Howard; R. Y. Chiao

1995-01-01T23:59:59.000Z

299

Automating Shallow Seismic Imaging  

SciTech Connect (OSTI)

This seven-year, shallow-seismic reflection research project had the aim of improving geophysical imaging of possible contaminant flow paths. Thousands of chemically contaminated sites exist in the United States, including at least 3,700 at Department of Energy (DOE) facilities. Imaging technologies such as shallow seismic reflection (SSR) and ground-penetrating radar (GPR) sometimes are capable of identifying geologic conditions that might indicate preferential contaminant-flow paths. Historically, SSR has been used very little at depths shallower than 30 m, and even more rarely at depths of 10 m or less. Conversely, GPR is rarely useful at depths greater than 10 m, especially in areas where clay or other electrically conductive materials are present near the surface. Efforts to image the cone of depression around a pumping well using seismic methods were only partially successful (for complete references of all research results, see the full Final Technical Report, DOE/ER/14826-F), but peripheral results included development of SSR methods for depths shallower than one meter, a depth range that had not been achieved before. Imaging at such shallow depths, however, requires geophone intervals of the order of 10 cm or less, which makes such surveys very expensive in terms of human time and effort. We also showed that SSR and GPR could be used in a complementary fashion to image the same volume of earth at very shallow depths. The primary research focus of the second three-year period of funding was to develop and demonstrate an automated method of conducting two-dimensional (2D) shallow-seismic surveys with the goal of saving time, effort, and money. Tests involving the second generation of the hydraulic geophone-planting device dubbed the ''Autojuggie'' showed that large numbers of geophones can be placed quickly and automatically and can acquire high-quality data, although not under rough topographic conditions. In some easy-access environments, this device could make SSR surveying considerably more efficient and less expensive, particularly when geophone intervals of 25 cm or less are required. The most recent research analyzed the difference in seismic response of the geophones with variable geophone spike length and geophones attached to various steel media. Experiments investigated the azimuthal dependence of the quality of data relative to the orientation of the rigidly attached geophones. Other experiments designed to test the hypothesis that the data are being amplified in much the same way that an organ pipe amplifies sound have so far proved inconclusive. Taken together, the positive results show that SSR imaging within a few meters of the earth's surface is possible if the geology is suitable, that SSR imaging can complement GPR imaging, and that SSR imaging could be made significantly more cost effective, at least in areas where the topography and the geology are favorable. Increased knowledge of the Earth's shallow subsurface through non-intrusive techniques is of potential benefit to management of DOE facilities. Among the most significant problems facing hydrologists today is the delineation of preferential permeability paths in sufficient detail to make a quantitative analysis possible. Aquifer systems dominated by fracture flow have a reputation of being particularly difficult to characterize and model. At chemically contaminated sites, including U.S. Department of Energy (DOE) facilities and others at Department of Defense (DOD) installations worldwide, establishing the spatial extent of the contamination, along with the fate of the contaminants and their transport-flow directions, is essential to the development of effective cleanup strategies. Detailed characterization of the shallow subsurface is important not only in environmental, groundwater, and geotechnical engineering applications, but also in neotectonics, mining geology, and the analysis of petroleum reservoir analogs. Near-surface seismology is in the vanguard of non-intrusive approaches to increase knowledge of the shallow subsurface; our

Steeples, Don W.

2004-12-09T23:59:59.000Z

300

FACT SHEET ON THE CONSEQUENCES OF A FAILED DRUG TEST  

Broader source: Energy.gov (indexed) [DOE]

SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST SHEET ON THE CONSEQUENCES OF A POSITIVE DRUG TEST The Secretary has determined that applicants for, and holders of, a DOE "Q" or "L" access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for federal employees, and Title 10 Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly, individuals who are either in, or are selected for, a TDP are subject to applicant, random, and "for cause" testing. The information below summarizes the consequences of a positive test for drugs for each category of

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Implementation Guidance, Drug Testing - December 3, 2007 | Department of  

Broader source: Energy.gov (indexed) [DOE]

Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 Implementation Guidance, Drug Testing - December 3, 2007 December 3, 2007 Implementation guidance for applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) selected for Testing Designated Positions (TDP) As established in his memorandum dated September 14, 2007, the Secretary has determined that applicants for, and holders of, a Department of Energy (DOE) Q or L access authorization (security clearance) will be in Testing Designated Positions (TDP) as specified in DOE Order 3792.3, Drug-Free Federal Workplace Testing Implementation Program, for Federal employees, and Title 10, Code of Federal Regulations, Part 707, Workplace Substance Abuse Programs at DOE Sites, for contractor employees. Accordingly,

302

Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors  

E-Print Network [OSTI]

Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. We demonstrated that curcumin inhibited 253JB-V and KU7 bladder cancer...

Chadalapaka, Gayathri

2013-03-14T23:59:59.000Z

303

Needle-free drug delivery using shock wave techniques  

E-Print Network [OSTI]

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

304

Essays on prescription drug benefits in Medicare managed care  

E-Print Network [OSTI]

In this thesis, I estimate a structural demand model for prescription drug benefits by Medicare beneficiaries using data from the Medicare HMO program. I then use the utility parameter estimates to explore other questions ...

Hall, Anne Elizabeth, 1971-

2005-01-01T23:59:59.000Z

305

Abstract 4036: Drug repurposing to treat melanoma brain metastases  

Science Journals Connector (OSTI)

...4036: Drug repurposing to treat melanoma brain metastases Terje Sundstrom 1 Jobin K...of patients with metastatic melanoma, brain metastases remain an intractable problem...target single genes or pathways critical to brain metastasis formation. In this work we...

Terje Sundstrøm; Jobin K. Varughese; Francisco Azuaje; Kjell Petersen; Clifford G. Tepper; Elizabeth Ingham; Lisa Even; Sarah Tam; Kai Ove Skaftnesmo; Morten Lund-Johansen; Rolf Bjerkvig; Katherine W. Ferrara; Frits A. Thorsen

2014-10-01T23:59:59.000Z

306

Revealing a Novel Mode of Action for an Osteoporosis Drug  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is a U.S. Food and Drug Administration (FDA)-approved treatment for decreasing fracture risk in osteoporosis. While raloxifene is as effective at reducing fracture risk as...

307

Support for new US bill to safeguard country's drug supply  

Science Journals Connector (OSTI)

The proposed 'Drug Safety and Accountability Act' would establish quality standards for the FDA, pharmaceutical firms and their contractors, who are increasingly based overseas where safeguards may be lower than ...

2010-08-01T23:59:59.000Z

308

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

309

Pharmacokinetic and Pharmacodynamic Drug Interactions with Ethanol (Alcohol)  

Science Journals Connector (OSTI)

Ethanol (alcohol) is one of the most widely used legal drugs in the world. Ethanol is metabolized by alcohol dehydrogenase (ADH) ... lead to a clinically significant pharmacokinetic interaction with ethanol, whic...

Lingtak-Neander Chan; Gail D. Anderson

2014-12-01T23:59:59.000Z

310

Engineered microtissue platforms for modeling human pathophysiology and drug metabolism  

E-Print Network [OSTI]

Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

Li, Cheri Yingjie

2013-01-01T23:59:59.000Z

311

Unsupervised Image Ranking Eva Hrster  

E-Print Network [OSTI]

these are the most interesting and relevant shots. For instance, if there are many images of the Golden Gate Bridge

Weinberger, Kilian

312

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network [OSTI]

directly for destruction by the body’s immune system. There are currently three antibody-drug conjugates and 11 ‘naked’ monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

313

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

314

Medical Image on the Go!  

Science Journals Connector (OSTI)

The idea for softcopy viewing of medical image outside the radiology reading room spread among the scientists in various fields for several years. An image could be read on workstation of all types, from desktop across movable to handheld. ... Keywords: DICOM, Imaging informatics, JPEG2000, Pervasive healthcare, Ubiquitous healthcare

Dragan Ivetic; Dinu Dragan

2011-08-01T23:59:59.000Z

315

User Science Images  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

PorousMedia3medres.png PorousMedia3medres.png ASCR: Carbon Dioxide Sequestration September 14, 2009 | Author(s): G. S. H. Pau, J. B. Bell, K. Pruess, A. S. Almgren, M. J. Lijewski, and K. Zhang | Category: Environmental Science | URL: http://esd.lbl.gov/research/projects/tough/documentation/proceedings/ Download Image: PorousMedia3medres.png | png | 159 KB Simulation of density-driven flow for CO2 storage in saline aquifers. Shown is a snapshot of the CO2 concentration after onset of convection overlayed on the AMR grid. Image courtesy of George Pau and John Bell (LBNL). Repo mp111 marcdayhydrogenflame.jpg ASCR: Lab-scale Flame Simulation September 1, 2009 | Author(s): M.S.Day, J.B. Bell, R.K. Cheng, S. Tachibana, V.E. Beckner and M.J. Lijewski (LBNL) | Category: Combustion | URL: https://apdec.org/APDEC_Progress_Fall09.shtml

316

Imaging alpha particle detector  

DOE Patents [OSTI]

A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

Anderson, D.F.

1980-10-29T23:59:59.000Z

317

Imaging alpha particle detector  

DOE Patents [OSTI]

A method and apparatus for detecting and imaging alpha particles sources is described. A conducting coated high voltage electrode (1) and a tungsten wire grid (2) constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source (3) to be quantitatively or qualitatively analyzed. A thin polyester film window (4) allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

Anderson, David F. (Los Alamos, NM)

1985-01-01T23:59:59.000Z

318

The Cosmic Background Imager  

E-Print Network [OSTI]

The Cosmic Background Imager (CBI) is an instrument designed to make images of the cosmic microwave background radiation and to measure its statistical properties on angular scales from about 3 arc minutes to one degree (spherical harmonic scales from l ~ 4250 down to l ~ 400). The CBI is a 13-element interferometer mounted on a 6 meter platform operating in ten 1-GHz frequency bands from 26 GHz to 36 GHz. The instantaneous field of view of the instrument is 45 arcmin (FWHM) and its resolution ranges from 3 to 10 arcmin; larger fields can be imaged by mosaicing. At this frequency and resolution, the primary foreground is due to discrete extragalactic sources, which are monitored at the Owens Valley Radio Observatory and subtracted from the CBI visibility measurements. The instrument has been making observations since late 1999 of both primordial CMB fluctuations and the Sunyaev-Zeldovich effect in clusters of galaxies from its site at an altitude of 5080 meters near San Pedro de Atacama, in northern Chile. Observations will continue until August 2001 or later. We present preliminary results from the first few months of observations.

T. J. Pearson; B. S. Mason; S. Padin; A. C. S. Readhead; M. C. Shepherd; J. Sievers; P. S. Udomprasert; J. K. Cartwright

2000-12-11T23:59:59.000Z

319

Fiducial marker for correlating images  

DOE Patents [OSTI]

The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains.

Miller, Lisa Marie (Rocky Point, NY); Smith, Randy J. (Wading River, NY); Warren, John B. (Port Jefferson, NY); Elliott, Donald (Hampton Bays, NY)

2011-06-21T23:59:59.000Z

320

Backscatter absorption gas imaging system  

DOE Patents [OSTI]

A video imaging system for detecting hazardous gas leaks. Visual displays of invisible gas clouds are produced by radiation augmentation of the field of view of an imaging device by radiation corresponding to an absorption line of the gas to be detected. The field of view of an imager is irradiated by a laser. The imager receives both backscattered laser light and background radiation. When a detectable gas is present, the backscattered laser light is highly attenuated, producing a region of contrast or shadow on the image. A flying spot imaging system is utilized to synchronously irradiate and scan the area to lower laser power requirements. The imager signal is processed to produce a video display.

McRae, Jr., Thomas G. (Livermore, CA)

1985-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Bistatic SAR: Imagery & Image Products.  

SciTech Connect (OSTI)

While typical SAR imaging employs a co-located (monostatic) RADAR transmitter and receiver, bistatic SAR imaging separates the transmitter and receiver locations. The transmitter and receiver geometry determines if the scattered signal is back scatter, forward scatter, or side scatter. The monostatic SAR image is backscatter. Therefore, depending on the transmitter/receiver collection geometry, the captured imagery may be quite different that that sensed at the monostatic SAR. This document presents imagery and image products formed from captured signals during the validation stage of the bistatic SAR research. Image quality and image characteristics are discussed first. Then image products such as two-color multi-view (2CMV) and coherent change detection (CCD) are presented.

Yocky, David A.; Wahl, Daniel E.; Jakowatz, Charles V,

2014-10-01T23:59:59.000Z

322

Image upload with broken thumbnail image | OpenEI Community  

Open Energy Info (EERE)

Image upload with broken thumbnail image Image upload with broken thumbnail image Home > Groups > Developer Rmckeel's picture Submitted by Rmckeel(297) Contributor 20 July, 2012 - 07:55 bug images wiki OpenEI users can upload images to the wiki by typing a new file name http://en.openei.org/wiki/File:My_new_file.jpg However, due to a caching timing issue, right after upload, the 120px-wide thumbnail has not yet been created by the time the fetier cache goes after it. Thus, the thumbnail appears broken. Is anyone up for debugging? For users uploading images, this can be fixed by forcing a reload of the page: Windows: ctrl + F5 Mac/Apple: Apple + R or command + R Linux: F5 Thanks! DIAGNOSTIC INFORMATION: BROKEN THUMBNAIL IMAGE HEADERS (RIGHT IMAGE, BUT CACHED BEFORE THUMBNAIL CREATED): Request URL:http://prod-http-80-800498448.us-east-1.elb.amazonaws.com/w/images/thumb/4/44/Powered_by_OpenEI_196x49_sc.png/120px-Powered_by_OpenEI_196x49_sc.png

323

Brave new interactions: performance-enhancing drugs for human-computer interaction  

Science Journals Connector (OSTI)

In sports, some athletes resort to performance enhancing drugs to gain an advantage. Similarly, people use pharmaceutical drugs to aid learning, dexterity, or concentration. We look at how such drugs could potentially be used to enhance interactions. ... Keywords: augmentation, boosting performance, enhanced interaction, performance-enhancing drugs

Henning Pohl

2014-04-01T23:59:59.000Z

324

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products  

Science Journals Connector (OSTI)

Gillman, P. K. ( 2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated Br. ... Gillman, P. K. ...

Anne Mai Wassermann; Eugen Lounkine; Laszlo Urban; Steven Whitebread; Shanni Chen; Kevin Hughes; Hongqiu Guo; Elena Kutlina; Alexander Fekete; Martin Klumpp; Meir Glick

2014-05-06T23:59:59.000Z

325

Trade Associations - The Chemical Alliance; Dyestuff Convention; American Drug Manufacturers Association.  

Science Journals Connector (OSTI)

Trade Associations - The Chemical Alliance; Dyestuff Convention; American Drug Manufacturers Association. ...

1918-01-01T23:59:59.000Z

326

Towards indexing representative images on the web  

Science Journals Connector (OSTI)

Even after 20 years of research on real-world image retrieval, there is still a big gap between what search engines can provide and what users expect to see. To bridge this gap, we present an image knowledge base, ImageKB, a graph representation of structured ... Keywords: image understanding, large-scale text to image translation, image knowledge base

Xin-Jing Wang; Zheng Xu; Lei Zhang; Ce Liu; Yong Rui

2012-10-01T23:59:59.000Z

327

Medical image classification with multiple kernel learning  

Science Journals Connector (OSTI)

Nowadays, medical images are generated by hospitals and medical centers rapidly. The large volume of medical image data produces a strong need to effective medical image retrieval. The visual characteristic of medical image, such as modality, anatomical ... Keywords: feature fusion, image classification, medical imaging, multiple kernel learning

Hong Wu; Hao Zhang; Chao Li

2010-12-01T23:59:59.000Z

328

Photogrammetry & Machine Vision 1. Image sensors  

E-Print Network [OSTI]

Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image. Remondino, N. D'Apuzzo Photogrammetry and Machine Vision ­ 1. Measurement in images (b) Camera calibration of Photogrammetry and Machine Vision Fully understand: 1. Image based 3D and 4D measurement 2. Image based 3D

Giger, Christine

329

ON THE CONTINUITY OF IMAGES BY TRANSMISSION IMAGING Abstract. Transmission imaging is an important imaging technique which is widely used in  

E-Print Network [OSTI]

ON THE CONTINUITY OF IMAGES BY TRANSMISSION IMAGING CHUNLIN WU Abstract. Transmission imaging imaging principle is quite different from that of reflection imaging used in our everyday life. As well scholars studied the application of TV regularization to processing images generated by transmission

Soatto, Stefano

330

Staring 2-D hadamard transform spectral imager  

DOE Patents [OSTI]

A staring imaging system inputs a 2D spatial image containing multi-frequency spectral information. This image is encoded in one dimension of the image with a cyclic Hadamarid S-matrix. The resulting image is detecting with a spatial 2D detector; and a computer applies a Hadamard transform to recover the encoded image.

Gentry, Stephen M. (Albuquerque, NM); Wehlburg, Christine M. (Albuquerque, NM); Wehlburg, Joseph C. (Albuquerque, NM); Smith, Mark W. (Albuquerque, NM); Smith, Jody L. (Albuquerque, NM)

2006-02-07T23:59:59.000Z

331

Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...both first-line and second-line anti-TB drugs...reduction in the transmission of TB. Supplemental material for...acetyltransferase eis confers kanamycin...20004-20009. Supplemental material Supplemental...and second-line drug resistance...

Patricia J. Campbell; Glenn P. Morlock; R. David Sikes; Tracy L. Dalton; Beverly Metchock; Angela M. Starks; Delaina P. Hooks; Lauren S. Cowan; Bonnie B. Plikaytis; James E. Posey

2011-02-07T23:59:59.000Z

332

Fluorescent microthermographic imaging  

SciTech Connect (OSTI)

In the early days of microelectronics, design rules and feature sizes were large enough that sub-micron spatial resolution was not needed. Infrared or IR thermal techniques were available that calculated the object`s temperature from infrared emission. There is a fundamental spatial resolution limitation dependent on the wavelengths of light being used in the image formation process. As the integrated circuit feature sizes began to shrink toward the one micron level, the limitations imposed on IR thermal systems became more pronounced. Something else was needed to overcome this limitation. Liquid crystals have been used with great success, but they lack the temperature measurement capabilities of other techniques. The fluorescent microthermographic imaging technique (FMI) was developed to meet this need. This technique offers better than 0.01{degrees}C temperature resolution and is diffraction limited to 0.3 {mu}m spatial resolution. While the temperature resolution is comparable to that available on IR systems, the spatial resolution is much better. The FMI technique provides better spatial resolution by using a temperature dependent fluorescent film that emits light at 612 nm instead of the 1.5 {mu}m to 12 {mu}m range used by IR techniques. This tutorial starts with a review of blackbody radiation physics, the process by which all heated objects emit radiation to their surroundings, in order to understand the sources of information that are available to characterize an object`s surface temperature. The processes used in infrared thermal imaging are then detailed to point out the limitations of the technique but also to contrast it with the FMI process. The FMI technique is then described in detail, starting with the fluorescent film physics and ending with a series of examples of past applications of FMI.

Barton, D.L.

1993-09-01T23:59:59.000Z

333

Radiation imaging apparatus  

DOE Patents [OSTI]

A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally. 15 figs.

Anger, H.O.; Martin, D.C.; Lampton, M.L.

1983-07-26T23:59:59.000Z

334

Radiation imaging apparatus  

DOE Patents [OSTI]

A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

Anger, Hal O. (Berkeley, CA); Martin, Donn C. (Berkeley, CA); Lampton, Michael L. (Berkeley, CA)

1983-01-01T23:59:59.000Z

335

Drug-Free Workplace Program UT-B Contracts Page 1 of 1  

E-Print Network [OSTI]

Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG-FREE, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

Pennycook, Steve

336

Neutron imaging with bent perfect crystals. I. Imaging conditions  

Science Journals Connector (OSTI)

Neutron imaging with bent crystals is considered in the linear approximation of neutron optics. A matrix formalism analogous to that of conventional lens optics is developed.

Stoica, A.D.

2001-05-22T23:59:59.000Z

337

Drug-SNPing: an integrated drug-based, protein interaction-based tagSNP-based pharmacogenomics platform for SNP genotyping  

Science Journals Connector (OSTI)

......Representative query results in the pipeline of Drug-SNPing. (A) Drug...results in the Drug-SNPing pipeline For the example of AHF (synonym...alignment and SNP identification pipeline. Bioinformatics (2009) 25...Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3......

Cheng-Hong Yang; Yu-Huei Cheng; Li-Yeh Chuang; Hsueh-Wei Chang

2013-03-15T23:59:59.000Z

338

User Science Images  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

KChenCastroHiRes2013.png KChenCastroHiRes2013.png HEP: CASTRO (Eulerian Radiation Hydrodynamics) Simulation February 6, 2013 | Author(s): Ke-Jung Chen | Category: Astrophysics | URL: http://www.nature.com/nature/journal/v494/n7435/full/494046a.html Download Image: KChenCastroHiRes2013.png | png | 3.6 MB Collision between two shells of matter ejected by a massive star in two pair-instability supernova eruptions, only years apart, just before the star dies, showing a slice through a corner of the event. Shell radius (red knots) is about 500 times the Earth-Sun distance. Colors represent gas density (red is highest, dark blue is lowest). Image courtesy of Ke-Jung Chen, School of Physics and Astronomy, Univ. Minnesota. Repo m1400 Otts271115snap.png NP: Core-Collapse Supernova October 24, 2012 | Author(s): C. D. OTT1 , E. ABDIKAMALOV , P. MÖSTA1 , R.

339

X-ray Imaging Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging and Spectro-microscopy: Imaging and Spectro-microscopy: the Present and the Future Stanford Synchrotron Radiation Laboratory October 8-9, 2002 Organizers: John Miao & Keith Hodgson A workshop on "X-ray Imaging and Spectro-microscopy: the Present and the Future" was held on October 8-9, 2002. This workshop, organized by John Miao (SSRL) and Keith Hodgson (SSRL) provided a forum to discuss the scientific applications of a variety of imaging and spectro-microscopic techniques, including photoemission electron microscopy (PEEM), angle resolved photoemission spectroscopy (ARPES), coherent diffraction imaging, x-ray microscopy, micro-tomography, holographic imaging, and x-ray micro-probe. Twelve invited speakers discussed the important scientific applications of these techniques, and also predicted the future scientific directions with the advance of instrumentation and x-ray sources. The workshop was well attended with over fifty registered attendees.

340

Reflective ghost imaging through turbulence  

SciTech Connect (OSTI)

Recent work has indicated that ghost imaging may have applications in standoff sensing. However, most theoretical work has addressed transmission-based ghost imaging. To be a viable remote-sensing system, the ghost imager needs to image rough-surfaced targets in reflection through long, turbulent optical paths. We develop, within a Gaussian-state framework, expressions for the spatial resolution, image contrast, and signal-to-noise ratio of such a system. We consider rough-surfaced targets that create fully developed speckle in their returns and Kolmogorov-spectrum turbulence that is uniformly distributed along all propagation paths. We address both classical and nonclassical optical sources, as well as a computational ghost imager.

Hardy, Nicholas D.; Shapiro, Jeffrey H. [Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

2011-12-15T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Flow cytometry aids basic cell biology research and drug discovery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Flow cytometry aids basic cell biology research and drug discovery Life Technologies Corporation and LANL have released the Attune® Acoustic Focusing Cytometer, featuring a reduced footprint, reduced consumables, and an affordable price. April 3, 2012 Attune® Acoustic Focusing Cytometer The Attune® Acoustic Focusing Cytometer achieves sample throughput at rates over 10 times faster than other cytometers-up to 1,000 μL per minute. In December 2009, Life Technologies Corporation announced the release of the Attune® Acoustic Focusing Cytometer, a first-of-its-kind cytometer system based on technology developed at Los Alamos National Laboratory (LANL). Examining cells has never been clearer with LANL's use of acoustic waves

342

Drugs affecting autonomic functions or the extrapyramidal system  

Science Journals Connector (OSTI)

Publisher Summary This chapter discusses the drugs that stimulate ?- and ?-adrenoceptors. These drugs include Adrenaline (epinephrine), ephedrine, and pseudoephrine. The effects of ephedrine and pseudoephedrine on the cardiovascular system are presented. Ephedrine and pseudoephedrine also have the potential for neuropsychiatric adverse events. The chapter discusses the adverse effects of levodopa, a drug that acts on dopamine receptors, on the nervous- and psychiatric-system. The adverse effects of dopamine receptor agonists are discussed on cardiovascular-, respiratory-, and nervous system. Most of the dopamine receptor agonists in current use are ergot derivatives, and these are known to cause serosal fibroinflammatory syndromes. The ergot alkaloids and related agents are discussed in the chapter. Despite the advent of the triptans, ergotamine is still used in the treatment of migraine, sometimes with predictable adverse effects.

Michael Schachter

2001-01-01T23:59:59.000Z

343

EMSL - atomic-resolution imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

atomic-resolution-imaging en Molecular Hydrogen Formation from Proximal Glycol Pairs on TiO2(110). http:www.emsl.pnl.govemslwebpublicationsmolecular-hydrogen-formation-proxima...

344

A matter of collection and detection for intraoperative and noninvasive near-infrared fluorescence molecular imaging: To see or not to see?  

SciTech Connect (OSTI)

Purpose: Although fluorescence molecular imaging is rapidly evolving as a new combinational drug/device technology platform for molecularly guided surgery and noninvasive imaging, there remains no performance standards for efficient translation of “first-in-humans” fluorescent imaging agents using these devices. Methods: The authors employed a stable, solid phantom designed to exaggerate the confounding effects of tissue light scattering and to mimic low concentrations (nM–pM) of near-infrared fluorescent dyes expected clinically for molecular imaging in order to evaluate and compare the commonly used charge coupled device (CCD) camera systems employed in preclinical studies and in human investigational studies. Results: The results show that intensified CCD systems offer greater contrast with larger signal-to-noise ratios in comparison to their unintensified CCD systems operated at clinically reasonable, subsecond acquisition times. Conclusions: Camera imaging performance could impact the success of future “first-in-humans” near-infrared fluorescence imaging agent studies.

Zhu, Banghe; Rasmussen, John C.; Sevick-Muraca, Eva M., E-mail: Eva.Sevick@uth.tmc.edu [Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas 77030 (United States)

2014-02-15T23:59:59.000Z

345

Image retrieval using Markov Random Fields and global image features  

Science Journals Connector (OSTI)

In this paper, we propose a direct image retrieval framework based on Markov Random Fields (MRFs) that exploits the semantic context dependencies of the image. The novelty of our approach lies in the use of different kernels in our non-parametric density ... Keywords: Markov processes, nonparametric statistics

Ainhoa Llorente; R. Manmatha; Stefan Rüger

2010-07-01T23:59:59.000Z

346

Descriptive image feature for object detection in medical images  

Science Journals Connector (OSTI)

Algorithms based on the local description of interest regions are well adapted to the task of detecting and matching equivalent points between two images. Classical descriptors such as SIFT or SURF are efficient when applied to regular images with rich ... Keywords: SURF, detection, feature, keypoint, vertebra

Fabian Lecron; Mohammed Benjelloun; Saïd Mahmoudi

2012-06-01T23:59:59.000Z

347

Processing Visual Images  

SciTech Connect (OSTI)

The back of the eye is lined by an extraordinary biological pixel detector, the retina. This neural network is able to extract vital information about the external visual world, and transmit this information in a timely manner to the brain. In this talk, Professor Litke will describe a system that has been implemented to study how the retina processes and encodes dynamic visual images. Based on techniques and expertise acquired in the development of silicon microstrip detectors for high energy physics experiments, this system can simultaneously record the extracellular electrical activity of hundreds of retinal output neurons. After presenting first results obtained with this system, Professor Litke will describe additional applications of this incredible technology.

Litke, Alan (UC Santa Cruz) [UC Santa Cruz

2006-03-27T23:59:59.000Z

348

Stress, Risk Taking, Alcohol/Drugs, and Parents as Partners  

E-Print Network [OSTI]

college � Particular Interests Alcohol and other drug abuse Prescription stimulant abuse Marijuana, bronchitis, Strep throat 9.0% Internet use/computer games 17.3% Finances 8.9% Depression 16.3% Alcohol use 8 other students are doing #12;Parents Still Matter! � In adolescents and young adults, shift

Stowell, Michael

349

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine  

Science Journals Connector (OSTI)

......toxicity urine Substance Abuse Detection methods Substance-Related...Tandem Mass Spectrometry Young Adult A death involving abuse of propylhexedrine and...decedent's computer and internet usage history indicated...and CEDIA for drugs of abuse. A full-scan (m......

Justin M. Holler; Shawn P. Vorce; Pamela C. McDonough-Bender; Joseph Magluilo; Jr.; Carol J. Solomon; Barry Levine

2011-01-01T23:59:59.000Z

350

Pharmacokinetics of tobramycin and gentamicin in abusers of intravenous drugs.  

Science Journals Connector (OSTI)

...Median duration (days) of 7 (1-100) 5 (1-100) 26 (5-60) symptoms before admis- sion (range) Reported drug usec Heroin 9 (50) 4 (33) 5 (83) Pentazocine-pyribenzamine 8 (44) 5 (42) 3 (50) ("T's and blues") Meperidine 5...

C H King; R J Creger; J J Ellner

1985-03-01T23:59:59.000Z

351

Optimization and Simulation in Drug Development -Review and Analysis  

E-Print Network [OSTI]

in the context of the pharmaceutical industry. 4 #12; 1 Introduction The presen-Eriksen and Jens Clausen Keywords: Pharmaceutical R&D, Drug Discovery and Development, Modelling and sim- ulation, Clinical Trial Simulation Portfolio optimization 1 #12; Contents 1 Introduction 5 2 Pharmaceutical products

352

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...review-article Minireview Energy Metabolism and Drug Efflux...of ATP. This suggests that energy metabolism and ATP production...treatment of XDR-TB patients in Argentina and is currently being used...bacterial targets involved in energy metabolism. These combinations...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

353

Cryogenic Chiral Chromatography for Rapid Resolution of Drug Candidates  

Science Journals Connector (OSTI)

Cryogenic Chiral Chromatography for Rapid Resolution of Drug Candidates ... The chromatographic resolution of three racemates is presented at temperature areas extending to the cryogenic area, down to ?25 °C. ... Although none of the studied compounds could be completely separated at room temperature, a baseline separation was achieved at cryogenic temperatures. ...

Martti Alkio; Olli Aaltonen; Harri Setälä

2005-09-13T23:59:59.000Z

354

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG &  

E-Print Network [OSTI]

Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG & PHARMACEUTICAL · What Kelly Scientific Resources or staffing agencies are and how they work?they work? · How to work Role: ­ Northern California Recruiting and Business efforts for Kelly Scientific Resources ­ Promote

Puglisi, Joseph

355

Protein Dynamics in Drug Combinations: a Linear Superposition  

E-Print Network [OSTI]

on cells and organisms. Little is known about how drugs affect protein dynamics that deter- mine or activity) of one of the cells proteins (Figure 1). The goal is to guide the cell from a ``sick state'' to a ``healthy state'' in a rational manner (or, in the case of cancer, from a living cancer cell to a dead

356

Molecular Fragment Mining for Drug Discovery Christian Borgelt1  

E-Print Network [OSTI]

Molecular Fragment Mining for Drug Discovery Christian Borgelt1 , Michael R. Berthold2 , and David will be active or inactive, so that future chemical tests can be focused on the most promis- ing candidates that discriminate between active and inactive molecules. In this paper we review this approach as well as two

Berthold, Michael R.

357

A PARYLENE BELLOWS ELECTROCHEMICAL ACTUATOR FOR INTRAOCULAR DRUG DELIVERY  

E-Print Network [OSTI]

Implant INTRODUCTION Water electrolysis using coplanar microelectrodes offers a promising pumping with the contents of the drug reservoir. Electrolysis-induced gas generation (phase change of water into hydrogen) water and then joined together (Figure 2). Electrolysis pumping is selected over other actuation methods

Meng, Ellis

358

Application of Ion Chromatography in Pharmaceutical and Drug Analysis  

Science Journals Connector (OSTI)

......provided. Citrate, acetate Bio-Rad HPX-87H...conductivity Measured this drug synthesis 52 (150 4.1 mm...sulfate. Including lithium, sodium, ammonium...hydrogen carbonate mixture synthesis byproduct. Method validation...9 to 100.3% or acetate. Pooled data, 99 exclusion......

Dennis Jenke

2011-08-01T23:59:59.000Z

359

Canadian study fuels move to limit rise in drug prices  

Science Journals Connector (OSTI)

... body charged with holding down the cost of patented drugs is proposing amendments to its pricing guidelines at the same time a study shows that Canadian ... guidelines at the same time a study shows that Canadian prices are often higher than the international median. The Canadian parliament recently extended patent protection ...

David Spurgeon

1993-04-29T23:59:59.000Z

360

Video surveillance with speckle imaging  

DOE Patents [OSTI]

A surveillance system looks through the atmosphere along a horizontal or slant path. Turbulence along the path causes blurring. The blurring is corrected by speckle processing short exposure images recorded with a camera. The exposures are short enough to effectively freeze the atmospheric turbulence. Speckle processing is used to recover a better quality image of the scene.

Carrano, Carmen J. (Livermore, CA); Brase, James M. (Pleasanton, CA)

2007-07-17T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Medical Image Segmentation Xiaolei Huang  

E-Print Network [OSTI]

(CAT), Magnetic Resonance Imaging (MRI), Ultrasound, and X-Ray, in standard DICOM formats are often for searching and mining in medical image archives. A chal- lenging problem is to segment regions with boundary-based classification approaches. We first review these two categories of methods and discuss the potential

Huang, Xiaolei

362

Image texture analysis of elastograms  

E-Print Network [OSTI]

generated elastograms to obtain effective texture features. Four image analysis techniques, co-occurrence statistics, wavelet decomposition, fractal analysis and granulomeay are used to extract a number of features from each image. The inclusions...-RESOLUTION FRACTAL ANALYSIS . . . . . . E. GRANULOMETRIC FEATURES . . F. DATA NORMALIZATION . G. SEPARABILITY MEASURE 13 13 . . . . . 14 . . . . . 20 . . . . . 29 33 36 36 IV TEXTURE ANALYSIS OF SIMULATED ELASTOGRAMS. . . . . . . . . . . 38 A. SIMULATION...

Hussain, Fasahat

2012-06-07T23:59:59.000Z

363

Spatial Sampling for Image Segmentation  

E-Print Network [OSTI]

AND ALONSO RAMIREZ­MANZANARES3 1 Centro de Investigacion en Matematicas A.C, Guanajuato GTO 36000, Mexico 2 Matematicas, Guanajuato GTO 36000, Mexico Email: mrivera@cimat.mx We present a novel framework for image­ processing in order to obtain a desired solution. On the other hand, the image segmentation is commonly

Rivera, Mariano

364

Dynamic Spectral Imaging: Improving Colposcopy  

Science Journals Connector (OSTI)

...image pixel of the cervix. The optical head provides uniform illumination with a focused and collimated white light-emitting diode, and imaging with magnification optics coupled to a 1,024 768, 8-bit/channel digital color CCD camera...

William P. Soutter; Emmanuel Diakomanolis; Deirdre Lyons; Sadaf Ghaem-Maghami; Tosin Ajala; Dimitrios Haidopoulos; Dimitrios Doumplis; Costas Kalpaktsoglou; Gerasimos Sakellaropoulos; Suzan Soliman; Karen Perryman; Vicky Hird; C. Hilary Buckley; Kitty Pavlakis; Sofia Markaki; Roberto Dina; Vourneen Healy; Costas Balas

2009-03-01T23:59:59.000Z

365

Nested Images Qiang Tong#1  

E-Print Network [OSTI]

Nested Images Qiang Tong#1 , Song-Hai Zhang#2 , Ralph R. Martin*3 , Paul L. Rosin*4 # Tsinghua.Rosin@cs.cardiff.ac.uk Abstract--A nested image is a form of artistic expression in which one or more secondary figures detects the enclosed outer contour of the figure to be nested, and then finds a place in the outer figure

Martin, Ralph R.

366

Contemporary Mathematics Wavelet Image Compression  

E-Print Network [OSTI]

fundamental problems in science and engineering, such as audio de-noising, signal compression, object in a way to fit the engineering model of image compression. 1. Introduction Wavelets are functions which and engineering. This thesis focuses on the processing of color images with the use of custom designed wavelet

Song, Myung-Sin

367

Image capture system colors transforms  

Science Journals Connector (OSTI)

The goal of this paper is to simulate the colors transforms of the reflected light from an illuminated object that passes trough an image capture system. We are interested to see the colors differences at the output of each component from which the light ... Keywords: CIE standards, human eye response, lenses and filters transmittance, spectral images

Toadere Florin

2010-02-01T23:59:59.000Z

368

Simultaneous acquisition of differing image types  

DOE Patents [OSTI]

A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. A method in one embodiment includes receiving an image from an image forming device; decomposing the image formed by the image forming device into multiple component parts based on type of imaging; receiving the component parts of the image; and outputting image information based on the component parts of the image. Additional systems and methods are presented.

Demos, Stavros G

2012-10-09T23:59:59.000Z

369

Potentially Inappropriate Drug Prescribing and Associated Factors in Nursing Homes  

Science Journals Connector (OSTI)

AbstractImportance Polymedication is frequent in nursing home (NH) residents. This increases the risk of potentially inappropriate drug prescribing (PIDP), which can lead to adverse drug events, such as falls and hospitalization. Objective To identify PIDP in NH residents and to investigate subject-related and NH structural and organizational factors associated with PIDP. Design Cross-sectional study. Setting A total of 175 \\{NHs\\} in Midi-Pyrénées region, South-Western France. Participants A total of 974 subjects randomly selected from the 6275 NH residents participating in the IQUARE study. Exposure Patients with PIDP. Main Outcomes and Measures PIDP was the main outcome measure. It was defined using a specific indicator, based on the Summary of Product Characteristics, on the Laroche list, and on residents' clinical data. PIDP was defined as the presence of at least 1 of the following criteria: (1) drug with an unfavorable benefit-to-risk ratio; (2) drug with questionable efficacy according to the Laroche list; (3) absolute contraindication; (4) significant drug-drug interaction. Associated factors were identified by using multivariable logistic regression models. Results Among the 974 residents included, 71% had PIDP. PIDP was more frequent in patients without dementia, with several comorbidities and taking multiple medications. In the multivariable analysis, age (odds ratio [OR] 1.02; 95% confidence interval [CI] 1.01–1.03) and Charlson Comorbidity Index (CCI; P = .003, CCI = 1 versus 0: OR1/0 1.22; 95% CI 0.85–1.74, CCI ? 2 versus 0: OR2/0 1.72; 95% CI 1.23–2.41) were associated with an increased likelihood of PIDP. By contrast, dementia was associated with a lower likelihood of PIDP (OR 0.70; 95% CI 0.53–0.94). Among NH structural and organizational characteristics, the access to psychiatric advice and/or to hospitalization in a psychiatric unit (OR 1.36; 95% CI 1.02–1.82) and the presence of a reevaluation of drug prescriptions (OR 1.45; 95% CI 1.07–1.96) were associated with an increased likelihood of PIDP. Conclusions and Relevance Our work suggests that some NH characteristics are associated with an increased likelihood of PIDP. Gaining a better understanding of the factors influencing PIDP, especially structural and organizational NH factors, can help to determine the interventions that should be implemented.

Charlène Cool; Philippe Cestac; Charlotte Laborde; Cécile Lebaudy; Laure Rouch; Benoit Lepage; Bruno Vellas; Philipe de Souto Barreto; Yves Rolland; Maryse Lapeyre-Mestre

2014-01-01T23:59:59.000Z

370

Validation of LC–TOF-MS Screening for Drugs, Metabolites, and Collateral Compounds in Forensic Toxicology Specimens  

Science Journals Connector (OSTI)

......quantitation of multiclass drugs of abuse and pharmaceuticals in hair...pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS...toxicology of emerging drugs of abuse. Therapeutic Drug Monitoring...police investigation of a Danish Internet company. Drug Testing and Analysis......

Fessessework Guale; Shahriar Shahreza; Jeffrey P. Walterscheid; Hsin-Hung Chen; Crystal Arndt; Anna T. Kelly; Ashraf Mozayani

2013-01-01T23:59:59.000Z

371

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.  

Science Journals Connector (OSTI)

...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...nanogels: a versatile platform for drug delivery to...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...

Bissan Al-Lazikani; Mishal Patel; Krishna Bulusu; and Mark Halling-Brown

2011-11-01T23:59:59.000Z

372

Fluid Imaging of Enhanced Geothermal Systems | Department of...  

Broader source: Energy.gov (indexed) [DOE]

Imaging of Enhanced Geothermal Systems Project objectives: Attempting to Image EGS Fracture & Fluid Networks; Employing joint Geophysical Imaging Technologies....

373

Current and Emerging Azole Antifungal Agents  

Science Journals Connector (OSTI)

...data are valid only if the methodology in M27-A is followed. The current standard may be obtained from NCCLS, 940 West Valley Road, Suite 1400, Wayne, PA 19087. Shown are the breakpoints for Candida species against the indicated agents...

Daniel J. Sheehan; Christopher A. Hitchcock; Carol M. Sibley

1999-01-01T23:59:59.000Z

374

TH?D?201C?08: Multi?Modal MRI SPECT and CT Imaging of Theranostic Nanoplatforms  

Science Journals Connector (OSTI)

Purpose: The development of non?invasive imaging techniques for the assessment of cancer treatment is rapidly becoming highly important. Magnetic Cationic Liposomes (MCL) that carry a cargo of anti?cancer drugs and magnetic nanoparticles that will selectively target primary and metastatic cancertumorsdeliver drugs to them and visualize their effects through magnetic resonance imaging(MRI)single photon emission computed tomography(SPECT) and fluorescence spectroscopy. The aim of the present study is to evaluate MCL as a versatile theranostic nanoplatform for enhanced drug deliveryimaging and monitoring of cancer treatment. Materials and Method: Poly?ethyleneglycol (PEG) coated cationic liposomes are loaded with superparamagnetic iron oxide nanoparticles (SPIONS) and tagged with the radioisotope Indium?111. MCL was administered to SCID mouse with metastatic (B16?F10) melanoma grown in the right flank. Pre?injection and post?injection MR and SPECT/CT images were used to assess response to magnetic targeting effects and tumor and organ distribution. Results:Tumor signal intensities in T2 weighted images decreased an average of 20±5% and T2* values decreased and average of 14±7ms in the absence of magnetic targeting. This compares to an average signal decrease of 57±12% and a decrease in T2* relaxation times of 27±8ms with the aid of external magnet showing up to 2?fold greater accumulation by magnetic targeting. SPECT/CT images showed the localization and distribution of MCL in the tumor.Conclusion: MR SPECT/CT and biodistribution analyses clearly show the efficacy of MCL as MRI contrast agents prove the use of magnetic guidance and demonstrate the potential of MCL as agents for imaging guidance and therapeutic delivery.

F Reynoso; E Gultepe; A Jhaveri; P Kulkarni; B Gershman; C Ferris; R Campbell; M Harisinghani; S Sridhar

2010-01-01T23:59:59.000Z

375

Digital holographic imaging of aquatic species  

E-Print Network [OSTI]

The aim of this thesis is to design, develop and implement a digital holographic imaging (DHI) system, capable of capturing three-dimensional (3D) images of aquatic species. The images produced by this system are used in ...

Domínguez-Caballero, José Antonio

2006-01-01T23:59:59.000Z

376

Imaging Oxygen Molecules Up Close | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Imaging Oxygen Molecules Up Close Imaging Oxygen Molecules Up Close ARRA-enabled upgrades enhance research capabilities STM images of the same TiO2(110) area upon O2 chemisorption...

377

SMB, X-Ray Spectroscopy & Imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Home X-Ray Spectroscopy & Imaging X-Ray Spectroscopy & Imaging SSRL has five hard X-ray Spectroscopy beamlines and three Microfocus Imaging beamlines dedicated to Biological and...

378

SMB, X-ray Fluorescence Imaging  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fluorescence Imaging X-ray Fluorescence Imaging X-ray fluorescence imaging utilizes the high brightness of SPEAR3 and focused beam generated by the uses of K-B optics, capillaries...

379

Semantic image representation for visual recognition  

E-Print Network [OSTI]

Flickr Images (F18) . . . . . . . . . . . . . . . A.1.5A.1.3. Flickr Images (F18) consists of 1, 800 images fromset. A detailed description of F18 is provided in Appendix.

Rasiwasia, Nikhil

2011-01-01T23:59:59.000Z

380

The Cosmic Background Imager  

E-Print Network [OSTI]

Design and performance details are given for the Cosmic Background Imager (CBI), an interferometer array that is measuring the power spectrum of fluctuations in the cosmic microwave background radiation (CMBR) for multipoles in the range 400 < l < 3500. The CBI is located at an altitude of 5000 m in the Atacama Desert in northern Chile. It is a planar synthesis array with 13 0.9-m diameter antennas on a 6-m diameter tracking platform. Each antenna has a cooled, low-noise receiver operating in the 26-36 GHz band. Signals are cross-correlated in an analog filterbank correlator with ten 1 GHz bands. This allows spectral index measurements which can be used to distinguish CMBR signals from diffuse galactic foregrounds. A 1.2 kHz 180-deg phase switching scheme is used to reject cross-talk and low-frequency pick-up in the signal processing system. The CBI has a 3-axis mount which allows the tracking platform to be rotated about the optical axis, providing improved (u,v) coverage and a powerful discriminant against false signals generated in the receiving electronics. Rotating the tracking platform also permits polarization measurements when some of the antennas are configured for the orthogonal polarization.

S. Padin; M. C. Shepherd; J. K. Cartwright; R. G. Keeney; B. S. Mason; T. J. Pearson; A. C. S. Readhead; W. L. Schaal; J. Sievers; P. S. Udomprasert; J. K. Yamasaki; W. L. Holzapfel; J. E. Carlstrom; M. Joy; S. T. Myers; A. Otarola

2001-10-05T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Reaction product imaging  

SciTech Connect (OSTI)

Over the past few years the author has investigated the photochemistry of small molecules using the photofragment imaging technique. Bond energies, spectroscopy of radicals, dissociation dynamics and branching ratios are examples of information obtained by this technique. Along with extending the technique to the study of bimolecular reactions, efforts to make the technique as quantitative as possible have been the focus of the research effort. To this end, the author has measured the bond energy of the C-H bond in acetylene, branching ratios in the dissociation of HI, the energetics of CH{sub 3}Br, CD{sub 3}Br, C{sub 2}H{sub 5}Br and C{sub 2}H{sub 5}OBr dissociation, and the alignment of the CD{sub 3} fragment from CD{sub 3}I photolysis. In an effort to extend the technique to bimolecular reactions the author has studied the reaction of H with HI and the isotopic exchange reaction between H and D{sub 2}.

Chandler, D.W. [Sandia National Laboratories, Livermore, CA (United States)

1993-12-01T23:59:59.000Z

382

E-Print Network 3.0 - anti-cancer drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer drug design Page: << < 1 2 3 4 5 > >> 1 Biology-based Drug Design Summary: - New...

383

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

384

Plasma Drug Activity in Patients on Treatment for Multidrug-Resistant Tuberculosis  

Science Journals Connector (OSTI)

...research-article Clinical Therapeutics Plasma Drug Activity in Patients on Treatment...Florida, USA Little is known about plasma drug concentrations relative to quantitative...the ratio of the time to detection of plasma-cocultured Mycobacterium tuberculosis...

Stellah G. Mpagama; Norah Ndusilo; Suzanne Stroup; Happiness Kumburu; Charles A. Peloquin; Jean Gratz; Eric R. Houpt; Gibson S. Kibiki; Scott K. Heysell

2013-11-18T23:59:59.000Z

385

Development of lymphatic drug delivery platforms for the treatment of carcinomas  

E-Print Network [OSTI]

, and evaluated in preclinical rodent models. The route of drug administration along with the controlled release of the drug from the platforms, both play an important role in improving the biopharmaceutical properties of these conjugates. This is demonstrated...

Cai, Shuang

2011-05-31T23:59:59.000Z

386

Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)  

Science Journals Connector (OSTI)

......poisoning Substance Abuse Detection Tandem Mass Spectrometry Young Adult We report two...available through the internet. Even though gov...substances have hit the internet drug market as a...medications and drugs of abuse were performed in......

Maria Wikström; Gunilla Thelander; Ingrid Nyström; Robert Kronstrand

2010-01-01T23:59:59.000Z

387

An Evaluation of Rapid Point-of-Collection Oral Fluid Drug-Testing Devices  

Science Journals Connector (OSTI)

......Street Drugs analysis Substance Abuse Detection instrumentation methods...ofincreasedtesting fordrugs of abuse intheworkplace,in treatment...matrix for detecting drugs of abuse (2-6). Mixed saliva,or...literature, researched the Internet, and contacteda variety of......

J. Michael Walsh; Ron Flegel; Dennis J. Crouch; Leo Cangianelli; Jakub Baudys

2003-10-01T23:59:59.000Z

388

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network [OSTI]

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

389

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network [OSTI]

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

390

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network [OSTI]

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

391

The Drug Evaluation and Classification Program in the state of Texas: a validation study  

E-Print Network [OSTI]

drug categories were most frequently called by DREs who evaluated subjects: depressants, 182; cannabis, 142; narcotic analgesics, 83; stimulants, 62; PCP, 18; inhalants, 4; and hallucinogens, 1. To determine which drug categories were most frequently...

Walden, Troy Duane

2005-08-29T23:59:59.000Z

392

E-Print Network 3.0 - antihistaminic drugs modify Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

amount of drug in GI tract y(t) amount of drug... 0.1386 per hour and A 1. Use Matlab to graph x and y. Estimate the highest level of antihistamine... for k1 0.06931,...

393

E-Print Network 3.0 - anticancer drug oracin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

results for: anticancer drug oracin Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

394

E-Print Network 3.0 - anticancer drug combretastatin-a2 Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: anticancer drug combretastatin-a2 Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

395

E-Print Network 3.0 - anticancer drug development Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: anticancer drug development Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

396

E-Print Network 3.0 - anticancer drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

results for: anticancer drug treatment Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

397

E-Print Network 3.0 - albumin impaired drug-binding Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acid concentrations and variants on Summary: such as quinidine to ORM1 S and* 5 * ORM1 F1 ( , ). drug-binding studies are warranted to determine the possible... . Drug Metab...

398

Changes in the characteristics of approved New Drug Applications for antihypertensives  

E-Print Network [OSTI]

In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

MacNeil, John Simon Howe

2007-01-01T23:59:59.000Z

399

The dual-piston jet injector and the viability of drug delivery  

E-Print Network [OSTI]

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

400

Medical data mining : improving information accessibility using online patient drug reviews  

E-Print Network [OSTI]

We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

Li, Yueyang Alice

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

E-Print Network 3.0 - anticancer drugs infusion Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drugs infusion Search Powered by Explorit Topic List Advanced Search Sample search results for: anticancer drugs infusion Page: << < 1 2 3 4 5 > >> 1 Friday, April 29, 2011 UNM...

402

E-Print Network 3.0 - activation inhibits drug-resistant Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as a function of: (i) the transmissibility (i.e., fitness) of the drug-resistant... that transmission of drug-resistant strains in Botswana could increase to ,15% by 2009 if...

403

Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)  

SciTech Connect (OSTI)

The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

Larson, S.M.; Finn, R.D.

1990-10-15T23:59:59.000Z

404

Image Logs | Open Energy Information  

Open Energy Info (EERE)

Image Logs Image Logs Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Technique: Image Logs Details Activities (2) Areas (1) Regions (0) NEPA(0) Exploration Technique Information Exploration Group: Downhole Techniques Exploration Sub Group: Well Log Techniques Parent Exploration Technique: Well Log Techniques Information Provided by Technique Lithology: Identify different lithological layers, rock composition, grain size, mineral, and clay content Stratigraphic/Structural: -Fault and fracture identification -Rock texture, porosity, and stress analysis -determine dip, thickness, and geometry of rock strata in vicinity of borehole -Detection of permeable pathways, fracture zones, faults Hydrological: Locate zones of aquifer inflow/outflow Thermal:

405

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring  

Science Journals Connector (OSTI)

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring ... Lipid-Based Nanomedicines for Cancer ...

Yoshihisa Namiki; Teruaki Fuchigami; Norio Tada; Ryo Kawamura; Satoshi Matsunuma; Yoshitaka Kitamoto; Masaru Nakagawa

2011-07-26T23:59:59.000Z

406

ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus  

Broader source: Energy.gov [DOE]

FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

407

E-Print Network 3.0 - antimalarial drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

disease pathophysiology, drug resistance... and antimalarial resistance, and optimising treatments for pregnant women melioidosis - conducting clinical... treatments,...

408

E-Print Network 3.0 - antiretroviral drug costs Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

409

Category:Hyperspectral Imaging | Open Energy Information  

Open Energy Info (EERE)

following page. H Hyperspectral Imaging Retrieved from "http:en.openei.orgwindex.php?titleCategory:HyperspectralImaging&oldid794160" Categories: Geothermal Passive Sensors...

410

Geothermal Ultrasonic Fracture Imager | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Geothermal Ultrasonic Fracture Imager Geothermal Ultrasonic Fracture Imager Development of a downhole wireline tool to characterize fractures in EGS wells in temperatures up to...

411

Nanometer Resolution Imaging by SIngle Molecule Switching. |...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nanometer Resolution Imaging by SIngle Molecule Switching. Nanometer Resolution Imaging by SIngle Molecule Switching. Abstract: The fluorescence intensity of single molecules can...

412

Promises and Challenges of Ghost Imaging  

Science Journals Connector (OSTI)

In this contribution we review research on the imaging protocol known as ghost (or coincidence) imaging. We also describe some current research directions within this topical area.

Boyd, Robert

413

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics  

Science Journals Connector (OSTI)

...transport of molecular drugs in cancer theranostics 10.1073/pnas.1220817110 Guizhi...drug transport platform for cancer theranostics. Although chemotherapeutic drugs are widely used in...promising TDT platform for targeted cancer theranostics. Results and Discussion Construction...

Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan

2013-01-01T23:59:59.000Z

414

Multiple-Drug Toxicity Caused by the Coadministration of 4-Methylmethcathinone (Mephedrone) and Heroin  

Science Journals Connector (OSTI)

......of Results Substance Abuse Detection Young Adult An accidental death...found for sale on the internet as a re- search chemical...be discovered through internet drug user forums. Multiple-DrugToxicity...considered a rare drug of abuse. However, in July 2009......

Amber J. Dickson; Shawn P. Vorce; Barry Levine; Marilyn R. Past

2010-04-01T23:59:59.000Z

415

Multiple Fatalities Involving a New Designer Drug: Para-Methyl-4-Methylaminorex  

Science Journals Connector (OSTI)

......so-called head shops or over the internet and are often described as not...submitted in a number of drug abuse deaths; some of which were...Aks S.E. Emerging drugs of abuse. Emergency Medicine Clinics...Future synthetic drugs of abuse. (1988) Castonguay, R......

S. Cosbey; S. Kirk; M. McNaul; L. Peters; B. Prentice; A. Quinn; S.P. Elliott; S.D. Brandt; R.P. Archer

2014-01-01T23:59:59.000Z

416

Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)  

Science Journals Connector (OSTI)

......chemistry poisoning Substance Abuse Detection Tandem Mass...available through the internet. Even though gov- ernments...substances have hit the internet drug market as a "safe...medications and drugs of abuse were performed in femoral...screened for drugs of abuse using an liquid chromatography......

Maria Wikström; Gunilla Thelander; Ingrid Nyström; Robert Kronstrand

2010-01-01T23:59:59.000Z

417

Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures  

E-Print Network [OSTI]

an enhanced survival rate in multicell spheroids compared to monolayer cultures, consistent with experimental observations, and indicate that the key factor determining this is drug penetration. An analysis of the large penetration of effective quantities of drugs deep into the tumour, due to drug transport being mainly

418

CABM Symposium Applications of NMR to structure-based drug design in structural  

E-Print Network [OSTI]

CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

Powers, Robert

419

Computer modeling reveals how surprisingly potent hepatitis C drug works  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

420

Fluid Imaging | Open Energy Information  

Open Energy Info (EERE)

Page Page Edit History Facebook icon Twitter icon » Fluid Imaging Jump to: navigation, search Contents 1 Geothermal Lab Call Projects for Fluid Imaging 2 Geothermal ARRA Funded Projects for Fluid Imaging Geothermal Lab Call Projects for Fluid Imaging Loading map... {"format":"googlemaps3","type":"ROADMAP","types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"limit":200,"offset":0,"link":"all","sort":[""],"order":[],"headers":"show","mainlabel":"","intro":"","outro":"","searchlabel":"\u2026 further results","default":"","geoservice":"google","zoom":14,"width":"600px","height":"350px","centre":false,"layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","icon":"","visitedicon":"","forceshow":true,"showtitle":true,"hidenamespace":false,"template":false,"title":"","label":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"locations":[{"text":"

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Molecular Imaging Applications in Nanomedicine  

Science Journals Connector (OSTI)

The purpose of this article is to explore how molecular imaging techniques can be used as useful adjunts in the development of “nanomedicine” and in personalizing treatment of patients....

King C.P. Li; Sunil D. Pandit; Samira Guccione…

2004-06-01T23:59:59.000Z

422

Spinning disk for compressive imaging  

Science Journals Connector (OSTI)

We report the first, to the best of our knowledge, experimental implementation of a spinning-disk configuration for high-speed compressive image acquisition. A single rotating mask...

Shen, H; Gan, L; Newman, N; Dong, Y; Li, C; Huang, Y; Shen, Y C

2012-01-01T23:59:59.000Z

423

High speed imaging television system  

DOE Patents [OSTI]

A television system for observing an event which provides a composite video output comprising the serially interlaced images the system is greater than the time resolution of any of the individual cameras.

Wilkinson, William O. (Silver Spring, MD); Rabenhorst, David W. (Silver Spring, MD)

1984-01-01T23:59:59.000Z

424

Imaging atoms in 3-D  

ScienceCinema (OSTI)

Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

Ercius, Peter

2014-06-27T23:59:59.000Z

425

Methods for functional brain imaging  

E-Print Network [OSTI]

Magnetic resonance imaging (MRI) has demonstrated the potential for non-invasive mapping of structure and function (fMRI) in the human brain. In this thesis, we propose a series of methodological developments towards ...

Witzel, Thomas, Ph. D. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

426

Imaging sunspots using helioseismic methods  

Science Journals Connector (OSTI)

...poorly understood areas in solar physics. Imaging local anomalous...sunspots and the surrounding solar active regions. By highlighting...Interpretation, Computer-Assisted methods Oscillometry methods Rheology methods Solar Activity Solar System Vibration

2005-01-01T23:59:59.000Z

427

Fast Progressive Lossless Image Compression  

E-Print Network [OSTI]

We present a method for progressive lossless compression of still grayscale images that combines the speed of our earlier FELICS method with the progressivity of our earlier MLP method We use MLP s pyramid based pixel ...

Howard, Paul G.; Vitter, Jeffrey Scott

1994-02-01T23:59:59.000Z

428

SMB 2014 - Imaging Summer School  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

users' guide to planning and conducting microXAS imaging experiments at SSRL beam lines. Students will participate in hands-on sessions at the beam lines, including on the...

429

Learning from local image regions  

E-Print Network [OSTI]

of-plane rotation of a teapot (data from [77], sub-sampledof-plane rotation of a teapot (data from [23], sub-sampledsampled from of physical a teapot the ground truth images;

Dollár, Piotr

2007-01-01T23:59:59.000Z

430

Electronic imaging fundamentals: Basic theory  

Science Journals Connector (OSTI)

Introduction of the computer into the field of medical imaging, as typified by the extensive use of digital subtraction angiography (DSA), created an important need for a basic understanding of the principles ...

Kalman N. Vizy P.E.

1983-11-01T23:59:59.000Z

431

Use of Preventative and Therapeutic Drugs in Show Market Animals  

E-Print Network [OSTI]

Various preventive and therapeutic medicines may be used for disease management in show mar- ket livestock and poultry. These include vaccines and bacterins, antibiotics and antibacterials, para- siticides and corticosteroids. Exhibitors of show ani.... These instructions are to be followed precisely. L-2335 2-01 Use of Preventive and Therapeutic Drugs in Show Market Animals F.C. Faries, Jr. Associate Professor and Extension Program Leader for Veterinary Medicine The Texas A&M University System Testing The Food...

Faries Jr., Floron C.

2001-03-12T23:59:59.000Z

432

The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout  

SciTech Connect (OSTI)

Gemfibrozil (GEM) is a fibrate drug consistently found in effluents from sewage treatment plants. This study characterizes the pharmacological effects of GEM on the plasma lipoproteins of rainbow trout (Oncorhynchus mykiss). Our goals were to quantify the impact of the drug on: 1) lipid constituents of lipoproteins (phospholipids (PL), triacylglycerol (TAG), and cholesterol), 2) lipoprotein classes (high, low and very low density lipoproteins), and 3) fatty acid composition of lipoproteins. Potential mechanisms of GEM action were investigated by measuring lipoprotein lipase activity (LPL) and the hepatic gene expression of LPL and of the peroxisome proliferator-activated receptor (PPAR) {alpha}, {beta}, and {gamma} isoforms. GEM treatment resulted in decreased plasma lipoprotein levels (- 29%) and a reduced size of all lipoprotein classes (lower PL:TAG ratios). However, the increase in HDL-cholesterol elicited by GEM in humans failed to be observed in trout. Therefore, HDL-cholesterol cannot be used to assess the impact of the drug on fish. GEM also modified lipoprotein composition by reducing the abundance of long-chain n-3 fatty acids, thereby potentially reducing the nutritional quality of exposed fish. The relative gene expression of LPL was increased, but the activity of the enzyme was not, and we found no evidence for the activation of PPAR pathways. The depressing effects of GEM on fish lipoproteins demonstrated here may be a concern in view of the widespread presence of fibrates in aquatic environments. Work is needed to test whether exposure to environmental concentrations of these drugs jeopardizes the capacity of fish for reproduction, temperature acclimation or migratory behaviors.

Prindiville, John S., E-mail: jprin041@uottawa.ca; Mennigen, Jan A.; Zamora, Jake M.; Moon, Thomas W.; Weber, Jean-Michel

2011-03-15T23:59:59.000Z

433

Radiopharmaceuticals for imaging the heart  

DOE Patents [OSTI]

Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

Green, M.A.; Tsang, B.W.

1994-06-28T23:59:59.000Z

434

Radiopharmaceuticals for imaging the heart  

DOE Patents [OSTI]

Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.

Green, Mark A. (West Lafayette, IN); Tsang, Brenda W. (Lafayette, IN)

1994-01-01T23:59:59.000Z

435

Soviet image pattern recognition research  

SciTech Connect (OSTI)

This report is an assessment of the published Soviet image pattern recognition (IPR) research and was written by a panel of six US academic experts in that research field. Image pattern recognition is a set of technological research topics involving automatic or interactive computer processing of pictorial information, utilizing optical, electronic, and computer technologies. This report focuses on IPR system configuration (optical, hybrid, digital), and current research. The topical chapter headings are Image Processing Hardware and Software Preprocessing, Statistical Pattern Recognition, Computer Vision, and Optical Techniques and Systems. Soviet research in all areas of IPR is strong in theory, but limited by poor availability of equipment for generating and handling digital images, and digital computer hardware and software. Nevertheless, some Soviet IPR achievements compare favorably with those of the West. There is strong Soviet research in statistical pattern recognition, where fundamental relationships related to the factors determining error rates in classification of images are being developed. There has been good Soviet work in enhancement and restoration of images (visible and radar) of the surface of Venus. There is a strong Soviet development program in optics and optical processing related to IPR. Nevertheless, the state of Soviet research in computer vision is ten to fifteen years behind the West, because of the lack of adequate hardware and software. The Soviet scientists in the area appear competent and knowledgeable of Western work, so that any improvement in their research output would be derived from access to more capable equipment. 402 refs., 4 figs., 4 tabs.

McKenney, B.L.; McGrain, M. (eds.) (Science Applications International Corp., McLean, VA (USA). Foreign Applied Sciences Assessment Center); Klinger, A. (California Univ., Los Angeles, CA (USA). Dept. of Computer Science); Aggarwal, J.K. (Texas Univ., Austin, TX (USA)); George, N.J. (Rochester Univ., NY (USA). Inst. of Optics); Haralick, R.M. (Washington Univ., Seattle, WA (USA). Dept. of Electric

1989-12-01T23:59:59.000Z

436

High speed imager test station  

DOE Patents [OSTI]

A test station enables the performance of a solid state imager (herein called a focal plane array or FPA) to be determined at high image frame rates. A programmable waveform generator is adapted to generate clock pulses at determinable rates for clock light-induced charges from a FPA. The FPA is mounted on an imager header board for placing the imager in operable proximity to level shifters for receiving the clock pulses and outputting pulses effective to clock charge from the pixels forming the FPA. Each of the clock level shifters is driven by leading and trailing edge portions of the clock pulses to reduce power dissipation in the FPA. Analog circuits receive output charge pulses clocked from the FPA pixels. The analog circuits condition the charge pulses to cancel noise in the pulses and to determine and hold a peak value of the charge for digitizing. A high speed digitizer receives the peak signal value and outputs a digital representation of each one of the charge pulses. A video system then displays an image associated with the digital representation of the output charge pulses clocked from the FPA. In one embodiment, the FPA image is formatted to a standard video format for display on conventional video equipment. 12 figs.

Yates, G.J.; Albright, K.L.; Turko, B.T.

1995-11-14T23:59:59.000Z

437

High speed imager test station  

DOE Patents [OSTI]

A test station enables the performance of a solid state imager (herein called a focal plane array or FPA) to be determined at high image frame rates. A programmable waveform generator is adapted to generate clock pulses at determinable rates for clock light-induced charges from a FPA. The FPA is mounted on an imager header board for placing the imager in operable proximity to level shifters for receiving the clock pulses and outputting pulses effective to clock charge from the pixels forming the FPA. Each of the clock level shifters is driven by leading and trailing edge portions of the clock pulses to reduce power dissipation in the FPA. Analog circuits receive output charge pulses clocked from the FPA pixels. The analog circuits condition the charge pulses to cancel noise in the pulses and to determine and hold a peak value of the charge for digitizing. A high speed digitizer receives the peak signal value and outputs a digital representation of each one of the charge pulses. A video system then displays an image associated with the digital representation of the output charge pulses clocked from the FPA. In one embodiment, the FPA image is formatted to a standard video format for display on conventional video equipment.

Yates, George J. (Santa Fe, NM); Albright, Kevin L. (Los Alamos, NM); Turko, Bojan T. (Moraga, CA)

1995-01-01T23:59:59.000Z

438

Image Based Gisting in CLIR Mark Sanderson  

E-Print Network [OSTI]

from the Rosch [1] paper. These search terms were entered into the Google Image search engine in order the ability of subjects to derive the search term that might have been used to return a set of images from on subjects' abilities in this respect. Search terms were defined and images found using an online image

Sanderson, Mark

439

Nuclear Imaging Probes: from Bench to Bedside  

Science Journals Connector (OSTI)

...specific imaging probes is the nuclear fuel for molecular imaging by positron emission...cancer. Cancer Res 2001;61:110-7. 24 Price DT, Coleman RE, Liao RP, Robertson CN...specific imaging probes is the nuclear fuel for molecular imaging by positron emission...

Hans-Jürgen Wester

2007-06-15T23:59:59.000Z

440

Forensic Imaging and Art Herbert Buckley  

E-Print Network [OSTI]

Forensic Imaging and Art Herbert Buckley Director, Forensic Imaging, New York State Police 4pm, Wed by the Forensic Imaging Office of the New York State Police are physiognomical (facial) reconstruction of skeletal of Forensic Imaging. Mr. Buckley has been a guest lecturer before the annual conclave of the New York State

Zanibbi, Richard

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Understanding User Intentions in Vertical Image Search  

E-Print Network [OSTI]

proposed for solving the image matching problem and object location problem in crowded scenes. Such method was further developed in [Stricker and Orengo, 1995] with improved indexing techniques to color information in dig- ital images. In [Huang et al...-tree, R-tree and its variant R+-tree and R?-tree, are usually not scalable to dimensions higher than 20 [White and Jain, 1996]. 2.2 Image annotation Image annotation or image tagging is an area closely related to image retrieval. Image anno- tation...

Chen, Yuxin

442

Temperature rise and safety considerations for radiation force ultrasound imaging  

Science Journals Connector (OSTI)

Current models for estimating temperature increase during ultrasound exposure calculate the steady?state rise using time?averaged acoustic output as the worst case for safety consideration. While valid for the typically very short (microsecond) pulses used by conventional diagnostic techniques this analysis does not necessarily correspond to a worst case scenario for the longer pulses or pulse bursts used by a new method radiation force imaging. Radiation force imaging employing ultrasound pulse durations up to hundreds of milliseconds produces and detects motion in solid tissue or acoustic streaming in fluids via a high intensity beam. Models that calculate the transient temperature rise from these pulses are developed for both the bone at focus and soft tissue cases. Based on accepted time–temperature dose criteria it is shown that for pulse lengths and intensities utilized by this technique temperature may increase to levels that raise safety concerns for bone at the focus of the ultrasound beam. Also the impact on this modality of the current U.S. Food and Drug Administration output limits for diagnostic ultrasound devices is discussed.

Bruce A. Herman; Gerald R. Harris

2002-01-01T23:59:59.000Z

443

Lensless Imaging of Magnetic Nanostructures  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Magnetic Lensless Imaging of Magnetic Nanostructures Lensless Imaging of Magnetic Nanostructures Print Wednesday, 28 March 2012 00:00 Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying the basics of magnetism, scientists aim to better understand the fundamental physical principles that govern magnetic systems, perhaps leading to important new technologies. The high brightness and coherence of the ALS's soft x-rays have enabled scientists to apply lensless x-ray imaging for the first time to nanometer-scale magnetic structures in an alloy. Many Ways To See You open your eyes and detect the light rays streaming through your bedroom window (transmission), illuminating your socks on the floor (scattering). You put on your glasses (refraction) to detect the state of your image in the mirror (reflection). If you are an ALS scientist, perhaps you go to work and shine some x-ray light on a crystal to detect the arrangement of the atoms in the crystal (diffraction). Now, thanks to Turner et al., you can also shine some x-ray light on a magnetic sample to detect the arrangement of its electron spins through a method known as lensless imaging. This last example is an equally valid way to "see," but instead of using windows, lenses, or mirrors to manipulate light and construct an image, mathematical formulas are used to describe the effects that particles and fields in the sample have on the light. These formulas have always contained terms that relate to the electron spin of magnetic atoms, but they were previously ignored. Using the full formula allows for the determination of not only crystal structure, but magnetic spin distribution and orientation as well, with a spatial resolution limited only by the wavelength of x-rays used. This promising method can be used at any coherent light source, including modern x-ray free-electron lasers, where ultrashort pulses would freeze-frame magnetic changes, offering the potential for imaging in unprecedented detail the structure and motion of boundaries between regions with different magnetic orientation.

444

Reduced-Reference Image Quality Assessment Using A Wavelet-Domain Natural Image Statistic Model  

E-Print Network [OSTI]

Reduced-Reference Image Quality Assessment Using A Wavelet-Domain Natural Image Statistic Model information about the reference images. In this paper, we propose an RR image quality assessment method based on a natural image statistic model in the wavelet transform domain. We use the Kullback-Leibler distance

Wang, Zhou

445

Image Forensic of Glare Feature for Improving Image Retrieval Using Benford's Law  

E-Print Network [OSTI]

Image Forensic of Glare Feature for Improving Image Retrieval Using Benford's Law Ghulam Qadir proposed technique is novel and has a potential to be an image forensic tool for quick image analysis. I. INTRODUCTION The field of digital image forensics is striving hard to restore the lost trust in digital content

Doran, Simon J.

446

STAR Images: Image gallery from the Solenoidal Tracker at RHIC  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The primary physics task of STAR is to study the formation and characteristics of the quark-gluon plasma (QGP), a state of matter believed to exist at sufficiently high energy densities. STAR consists of several types of detectors, each specializing in detecting certain types of particles or characterizing their motion. These detectors allow final statements to be made about the collision. The gallery of STAR images makes available a small collection of event-generated images from Gold-Beam experiments, a simulation of TCP Drift, and a library of STAR instrument and construction photos. [See also DDE00093

447

TU?D?303A?03: Inorganic Nanoparticles for Molecular Imaging  

Science Journals Connector (OSTI)

Nanotechnology an interdisciplinary research field involving chemistry engineering biology medicine and more has great potential for early detection accurate diagnosis and personalized treatment of diseases. Molecular imaging refers to the characterization and measurement of biological processes at the cellular and/or molecular level. It can give whole?body readout in an intact system dramatically decrease the workload and reduce the cost of biomedical research and drug development provide more statistically relevant results since longitudinal studies can be performed in the same animals aid in early lesion detection in patients and patient stratification and help in individualized treatment monitoring and dose optimization.

X Chen

2009-01-01T23:59:59.000Z

448

Multispectral Imaging | Open Energy Information  

Open Energy Info (EERE)

Multispectral Imaging Multispectral Imaging Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Technique: Multispectral Imaging Details Activities (35) Areas (22) Regions (1) NEPA(0) Exploration Technique Information Exploration Group: Remote Sensing Techniques Exploration Sub Group: Passive Sensors Parent Exploration Technique: Passive Sensors Information Provided by Technique Lithology: relative mineral maps Stratigraphic/Structural: aerial photographs can show structures Hydrological: delineate locations of surface water features Thermal: vegetation maps can show plants stressed due to nearby thermal activity Cost Information Low-End Estimate (USD): 10.001,000 centUSD 0.01 kUSD 1.0e-5 MUSD 1.0e-8 TUSD / sq. mile Median Estimate (USD): 370.2337,023 centUSD

449

HAWC Observatory captures first image  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

April » April » HAWC Observatory captures first image HAWC Observatory captures first image The facility is designed to detect cosmic rays and the highest energy gamma rays ever observed from astrophysical sources. April 30, 2013 The High-Altitude Water Cherenkov (HAWC) Observatory is under construction. The High-Altitude Water Cherenkov (HAWC) Observatory is under construction. HAWC is under construction inside the Parque Nacional Pico de Orizaba, a Mexican national park. An international team of researchers, including scientists from Los Alamos, has taken the first image of the High-Altitude Water Cherenkov Observatory, or HAWC. The facility is designed to detect cosmic rays and the highest energy gamma rays ever observed from astrophysical sources. HAWC is under

450

70 Images for 70 Years  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

70 Images for 70 Years 70 Images for 70 Years 70 Images for 70 Years Los Alamos has a proud history and heritage of almost 70 years of science and innovation. The people of the Laboratory work on advanced technologies to provide the best scientific and engineering solutions to many of the nation's most crucial security challenges. Click thumbnails to enlarge. Photos arranged by most recent first, horizontal formats before vertical. See Flickr for more sizes and details. 1938 Hahn and Meitner Fission 1938 Hahn and Meitner Fission 1939 Einstein-Szilard 1939 Einstein-Szilard 1940s Main Guard Gate (671938) 1940s Main Guard Gate (671938) 1940s Security check 1940s Security check 1940 Boys Ranch School hockey on Ashley Pond 1940 Boys Ranch School hockey on Ashley Pond 1942 Fuller Lodge 1942 Fuller Lodge

451

Hyperspectral Imaging | Open Energy Information  

Open Energy Info (EERE)

Hyperspectral Imaging Hyperspectral Imaging Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Technique: Hyperspectral Imaging Details Activities (4) Areas (4) Regions (1) NEPA(1) Exploration Technique Information Exploration Group: Remote Sensing Techniques Exploration Sub Group: Passive Sensors Parent Exploration Technique: Passive Sensors Information Provided by Technique Lithology: mineral maps can be used to show the presence of hydrothermal minerals and mineral assemblages Stratigraphic/Structural: aerial photographs can show structures Hydrological: delineate locations of surface water features Thermal: vegetation maps can show plants stressed due to nearby thermal activity Cost Information Low-End Estimate (USD): 8.63863 centUSD 0.00863 kUSD 8.63e-6 MUSD

452

Lensless Imaging of Magnetic Nanostructures  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Magnetic Nanostructures Print Lensless Imaging of Magnetic Nanostructures Print Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying the basics of magnetism, scientists aim to better understand the fundamental physical principles that govern magnetic systems, perhaps leading to important new technologies. The high brightness and coherence of the ALS's soft x-rays have enabled scientists to apply lensless x-ray imaging for the first time to nanometer-scale magnetic structures in an alloy. Many Ways To See You open your eyes and detect the light rays streaming through your bedroom window (transmission), illuminating your socks on the floor (scattering). You put on your glasses (refraction) to detect the state of your image in the mirror (reflection). If you are an ALS scientist, perhaps you go to work and shine some x-ray light on a crystal to detect the arrangement of the atoms in the crystal (diffraction). Now, thanks to Turner et al., you can also shine some x-ray light on a magnetic sample to detect the arrangement of its electron spins through a method known as lensless imaging. This last example is an equally valid way to "see," but instead of using windows, lenses, or mirrors to manipulate light and construct an image, mathematical formulas are used to describe the effects that particles and fields in the sample have on the light. These formulas have always contained terms that relate to the electron spin of magnetic atoms, but they were previously ignored. Using the full formula allows for the determination of not only crystal structure, but magnetic spin distribution and orientation as well, with a spatial resolution limited only by the wavelength of x-rays used. This promising method can be used at any coherent light source, including modern x-ray free-electron lasers, where ultrashort pulses would freeze-frame magnetic changes, offering the potential for imaging in unprecedented detail the structure and motion of boundaries between regions with different magnetic orientation.

453

Lensless Imaging of Magnetic Nanostructures  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Magnetic Nanostructures Print Lensless Imaging of Magnetic Nanostructures Print Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying the basics of magnetism, scientists aim to better understand the fundamental physical principles that govern magnetic systems, perhaps leading to important new technologies. The high brightness and coherence of the ALS's soft x-rays have enabled scientists to apply lensless x-ray imaging for the first time to nanometer-scale magnetic structures in an alloy. Many Ways To See You open your eyes and detect the light rays streaming through your bedroom window (transmission), illuminating your socks on the floor (scattering). You put on your glasses (refraction) to detect the state of your image in the mirror (reflection). If you are an ALS scientist, perhaps you go to work and shine some x-ray light on a crystal to detect the arrangement of the atoms in the crystal (diffraction). Now, thanks to Turner et al., you can also shine some x-ray light on a magnetic sample to detect the arrangement of its electron spins through a method known as lensless imaging. This last example is an equally valid way to "see," but instead of using windows, lenses, or mirrors to manipulate light and construct an image, mathematical formulas are used to describe the effects that particles and fields in the sample have on the light. These formulas have always contained terms that relate to the electron spin of magnetic atoms, but they were previously ignored. Using the full formula allows for the determination of not only crystal structure, but magnetic spin distribution and orientation as well, with a spatial resolution limited only by the wavelength of x-rays used. This promising method can be used at any coherent light source, including modern x-ray free-electron lasers, where ultrashort pulses would freeze-frame magnetic changes, offering the potential for imaging in unprecedented detail the structure and motion of boundaries between regions with different magnetic orientation.

454

Lensless Imaging of Magnetic Nanostructures  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Magnetic Nanostructures Print Lensless Imaging of Magnetic Nanostructures Print Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying the basics of magnetism, scientists aim to better understand the fundamental physical principles that govern magnetic systems, perhaps leading to important new technologies. The high brightness and coherence of the ALS's soft x-rays have enabled scientists to apply lensless x-ray imaging for the first time to nanometer-scale magnetic structures in an alloy. Many Ways To See You open your eyes and detect the light rays streaming through your bedroom window (transmission), illuminating your socks on the floor (scattering). You put on your glasses (refraction) to detect the state of your image in the mirror (reflection). If you are an ALS scientist, perhaps you go to work and shine some x-ray light on a crystal to detect the arrangement of the atoms in the crystal (diffraction). Now, thanks to Turner et al., you can also shine some x-ray light on a magnetic sample to detect the arrangement of its electron spins through a method known as lensless imaging. This last example is an equally valid way to "see," but instead of using windows, lenses, or mirrors to manipulate light and construct an image, mathematical formulas are used to describe the effects that particles and fields in the sample have on the light. These formulas have always contained terms that relate to the electron spin of magnetic atoms, but they were previously ignored. Using the full formula allows for the determination of not only crystal structure, but magnetic spin distribution and orientation as well, with a spatial resolution limited only by the wavelength of x-rays used. This promising method can be used at any coherent light source, including modern x-ray free-electron lasers, where ultrashort pulses would freeze-frame magnetic changes, offering the potential for imaging in unprecedented detail the structure and motion of boundaries between regions with different magnetic orientation.

455

Lensless Imaging of Magnetic Nanostructures  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lensless Imaging of Magnetic Nanostructures Print Lensless Imaging of Magnetic Nanostructures Print Magnetism is useful for many devices and techniques, from electric motors and computer hard drives to magnetic resonance imaging used in medicine. By studying the basics of magnetism, scientists aim to better understand the fundamental physical principles that govern magnetic systems, perhaps leading to important new technologies. The high brightness and coherence of the ALS's soft x-rays have enabled scientists to apply lensless x-ray imaging for the first time to nanometer-scale magnetic structures in an alloy. Many Ways To See You open your eyes and detect the light rays streaming through your bedroom window (transmission), illuminating your socks on the floor (scattering). You put on your glasses (refraction) to detect the state of your image in the mirror (reflection). If you are an ALS scientist, perhaps you go to work and shine some x-ray light on a crystal to detect the arrangement of the atoms in the crystal (diffraction). Now, thanks to Turner et al., you can also shine some x-ray light on a magnetic sample to detect the arrangement of its electron spins through a method known as lensless imaging. This last example is an equally valid way to "see," but instead of using windows, lenses, or mirrors to manipulate light and construct an image, mathematical formulas are used to describe the effects that particles and fields in the sample have on the light. These formulas have always contained terms that relate to the electron spin of magnetic atoms, but they were previously ignored. Using the full formula allows for the determination of not only crystal structure, but magnetic spin distribution and orientation as well, with a spatial resolution limited only by the wavelength of x-rays used. This promising method can be used at any coherent light source, including modern x-ray free-electron lasers, where ultrashort pulses would freeze-frame magnetic changes, offering the potential for imaging in unprecedented detail the structure and motion of boundaries between regions with different magnetic orientation.

456

Imaging with the invisible light  

E-Print Network [OSTI]

We describe a UV photo-detector with single photon(electron) counting and imaging capability. It is based on a CsI photocathode, a GEM charge multiplier and a self triggering CMOS analog pixel chip with 105k pixels at 50 micron pitch. The single photoelectron produced by the absorption of a UV photon is drifted to and multiplied inside a single GEM hole. The coordinates of the GEM avalanche are reconstructed with high accuracy (4 micron rms) by the pixel chip. As a result the map of the GEM holes, arranged on a triangular pattern at 50micron pitch, is finely imaged.

R. Bellazzini; G. Spandre; A. Brez; M. Minuti; L. Baldini; L. Latronico; M. M. Massai; N. Omodei; M. Pesce-Rollins; C Sgró; M. Razzano; M. Pinchera; J. Bregeon; M. Kuss; A. Braem

2007-03-19T23:59:59.000Z

457

Gamma-ray Imaging Methods  

SciTech Connect (OSTI)

In this document we discuss specific implementations for gamma-ray imaging instruments including the principle of operation and describe systems which have been built and demonstrated as well as systems currently under development. There are several fundamentally different technologies each with specific operational requirements and performance trade offs. We provide an overview of the different gamma-ray imaging techniques and briefly discuss challenges and limitations associated with each modality (in the appendix we give detailed descriptions of specific implementations for many of these technologies). In Section 3 we summarize the performance and operational aspects in tabular form as an aid for comparing technologies and mapping technologies to potential applications.

Vetter, K; Mihailescu, L; Nelson, K; Valentine, J; Wright, D

2006-10-05T23:59:59.000Z

458

Electronic imaging system and technique  

DOE Patents [OSTI]

A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

Bolstad, Jon O. (Idaho Falls, ID)

1987-01-01T23:59:59.000Z

459

Functional magnetic resonance imaging: imaging techniques and contrast mechanisms  

Science Journals Connector (OSTI)

...Furthermore, in a study of motor recovery, fMRI activation...focal lesion. The future should also see further...able to harness this quantum physics phenomenon...Functional imaging of the motor system. Curr. Opin...assessment with a graded motor activation procedure...past, present, and future. Proc. Natl Acad...

1999-01-01T23:59:59.000Z

460

Definition: Hyperspectral Imaging | Open Energy Information  

Open Energy Info (EERE)

Imaging Imaging Jump to: navigation, search Dictionary.png Hyperspectral Imaging Hyperspectral sensors collect data across a wide range of the spectrum (VNIR-LWIR, plus TIR) at small spectral resolution (5-15 nm) and high spatial resolution (1-5 m). This allows detailed spectral signatures to be identified for different imaged materials - for example hyperspectral imaging can be used to identify specific clay minerals; multispectral imaging can identify only the presence of clay minerals in general. View on Wikipedia Wikipedia Definition Hyperspectral imaging, like other spectral imaging, collects and processes information from across the electromagnetic spectrum. Much as the human eye sees visible light in three bands (red, green, and blue), spectral imaging divides the spectrum into many more bands. This technique

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Interaction networks: From protein functions to drug discovery. A review  

E-Print Network [OSTI]

-IMAG Laboratory, TIMB Team, faculté de médecine, 38706 La Tronche cedex, France Received 22 September 2008 on protein functions, signalling and metabolic pathways, and physiological processes, unraveled the molecular (interactome, transcriptome, phenome, localization) to switch from static to dynamic interaction networks

Thierry-Mieg, Nicolas

462

Local drug delivery for enhancing fracture healing in osteoporotic bone  

Science Journals Connector (OSTI)

Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllönen; Matteo D’Este; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

463

Method for the efficient incoherent analysis of particle image velocimetry images  

SciTech Connect (OSTI)

A method for the efficient analysis of PIV images is discussed that leads torapid image processing with the maximum extraction of data.

Grant, I.; Liu, A.

1989-05-15T23:59:59.000Z

464

Hadamard multimode optical imaging transceiver  

DOE Patents [OSTI]

Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture.

Cooke, Bradly J; Guenther, David C; Tiee, Joe J; Kellum, Mervyn J; Olivas, Nicholas L; Weisse-Bernstein, Nina R; Judd, Stephen L; Braun, Thomas R

2012-10-30T23:59:59.000Z

465

Low field magnetic resonance imaging  

DOE Patents [OSTI]

A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.

Pines, Alexander (Berkeley, CA); Sakellariou, Dimitrios (Billancourt, FR); Meriles, Carlos A. (Fort Lee, NJ); Trabesinger, Andreas H. (London, GB)

2010-07-13T23:59:59.000Z

466

Imaging Robot Jonathan Dyssel Stets  

E-Print Network [OSTI]

with a Command File, a file that contains the coordinates and directions of the robot arm. One of the interfaces and an attached camera. The other interface, programmed in Matlab, controls the calculations of the robot armImaging Robot Jonathan Dyssel Stets Kongens Lyngby 2010 IMM-B.Sc-2010-42 #12;Technical University

467

Imaging Genetics --Towards Discovery Neuroscience  

E-Print Network [OSTI]

variants that influence measures derived from anatomical or functional brain im- ages, which are in turn related to brain-related illnesses or fundamental cognitive, emotional and behavioral processes a tremendous growth in brain imaging as well as an enor- mous explosion of interest and success in genomics

Feng, Jianfeng

468

Covered Product Category: Imaging Equipment  

Broader source: Energy.gov [DOE]

FEMP provides acquisition guidance and Federal efficiency requirements across a variety of product categories, including imaging equipment, which is covered by the ENERGY STAR® program. Federal laws and requirements mandate that agencies meet these efficiency requirements in all procurement and acquisition actions that are not specifically exempted by law.

469

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

Science Journals Connector (OSTI)

Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

470

A client management system for criminal justice referrals to drug abuse treatment  

E-Print Network [OSTI]

. These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

Pate, Wayland Gordon

2012-06-07T23:59:59.000Z

471

ORISE Research Participation Programs at the U.S. Food and Drug...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Research Participation Programs at the U.S. Food and Drug Administration (FDA) Home About FDA About ORISE Current Research Opportunities Site Map Contact ORISE Facebook Twitter...

472

E-Print Network 3.0 - antiepileptic drugs carbamazepine Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: antiepileptic drugs carbamazepine Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth defects in association with intrauterine exposure to folic acid Summary: to...

473

E-Print Network 3.0 - antiarrhythmic drug therapy Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Biology and Medicine 13 TEXAS A&M UNIVERSITY LIBRARIES CITING THE INTERNET USING CSE STYLE Summary: Institute on Drug Abuse (US); 1994 revised 2000 Jul; cited...

474

E-Print Network 3.0 - act drug policies Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Immunology, Stanford University Collection: Biology and Medicine 14 BRIGHAM YOUNG UNIVERSITY Report of Institutional Compliance with the Drug-Free Schools and...

475

E-Print Network 3.0 - antiviral drug design Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Pharmacology and Pharmaceutical Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized...

476

Drug trafficking and gun carrying: a co-occurring phenomenon among urban male youth.  

E-Print Network [OSTI]

??This study examines an often-observed, but rarely studied, phenomenon of drug trafficking and gun carrying behaviors among urban male youth, as much of social science… (more)

Allen, Andrea Nicole

2009-01-01T23:59:59.000Z

477

E-Print Network 3.0 - anti-tuberculosis drug resistance Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University Collection: Biology and Medicine 10 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

478

E-Print Network 3.0 - anti-inflammatory drug naproxen Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Biology and Medicine ; Environmental Sciences and Ecology 47 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

479

E-Print Network 3.0 - anti-inflammatory drug-induced ulcer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

<< < 1 2 3 4 5 > >> Page: << < 1 2 3 4 5 > >> 61 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: episodic arthritis, which...

480

E-Print Network 3.0 - anti-inflammatory drug etoricoxib Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Vanderbilt University Collection: Biology and Medicine ; Chemistry 4 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

Note: This page contains sample records for the topic "imaging antifungal drug" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

E-Print Network 3.0 - antituberculosis drug-induced hepatotoxicity...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Biology and Medicine ; Mathematics 14 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

482

E-Print Network 3.0 - anti-tuberculosis drug ethionamide Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Harvard University Collection: Biology and Medicine 5 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

483

E-Print Network 3.0 - antituberculosis drugs carriers Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Harvard University Collection: Biology and Medicine 3 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

484

E-Print Network 3.0 - antituberculosis drug resistance Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

British Columbia Collection: Biology and Medicine 12 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

485

E-Print Network 3.0 - adrs adverse drug Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine ; Environmental Sciences and Ecology 60 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

486

E-Print Network 3.0 - adverse drug interactions Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 12 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: ; Early labels decorative Drug...

487

E-Print Network 3.0 - antibacterial drug resistances Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Exposing plasmids as the Achilles' heel of drug-resistant bacteria Summary: in the pharmaceutical industry away from the development of novel antibacterials 4,5. New...

488

E-Print Network 3.0 - anti-infective drugs advisory Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug classes of anti-infectives and their mechanisms of action... advisory role or in the pharmaceutical industry. An interest in antibiotic prescribing practice... changes to...

489

E-Print Network 3.0 - anticholinergic antiparkinson drugs Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

4 5 > >> 1 Arch Intern Med . Author manuscript Drugs with anticholinergic properties, cognitive decline, and dementia in Summary: Arch Intern Med . Author manuscript Page 1 14...

490

E-Print Network 3.0 - aerosolized drugs encapsulated Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of California at San Diego Collection: Materials Science 11 Boosting medicine with nanotechnology strengthens drug cocktail many times over http:...

491

E-Print Network 3.0 - antipsychotic drug treatment Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 38 PHARMACOGENETICS OF PARKINSONISM, RIGIDITY, Summary: Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

492

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

493

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

494

Mold-Templated Inorganic–Organic Hybrid Supraparticles for Codelivery of Drugs  

Science Journals Connector (OSTI)

Mold-Templated Inorganic–Organic Hybrid Supraparticles for Codelivery of Drugs ... The Bionics Institute acknowledges funding from the Victorian Government's Operational Infrastructure Support Program. ...

James W. Maina; Jiwei Cui; Mattias Björnmalm; Andrew K. Wise; Robert K. Shepherd; Frank Caruso

2014-10-16T23:59:59.000Z

495

E-Print Network 3.0 - antimicrobial drug resistance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

496

E-Print Network 3.0 - antimicrobial drug resistanceestudio Sample...  

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Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

497

E-Print Network 3.0 - aetiology antimicrobial drug Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

498

E-Print Network 3.0 - anti-malarial drug precursor Sample Search...  

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JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

499

E-Print Network 3.0 - anti-malarial drug quality Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

500

E-Print Network 3.0 - anti-malarial drug sensitivity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...