Sample records for imaging antifungal drug

  1. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  2. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  3. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  4. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  5. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: FermiSliSANANov, 1.Imaging

  6. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  7. Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids

    E-Print Network [OSTI]

    Barron, Annelise E.

    Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids that circumvent fungal drug- resistance mechanisms. In this work we used soft X-ray tomogra- phy to image of an entire, fully functional biological system, i.e., in the milieu of a cell (8, 10). Recently, soft X-ray

  8. PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.

    SciTech Connect (OSTI)

    Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

    2001-01-29T23:59:59.000Z

    There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain. This will be followed by highlights of PET studies of the acute effects of the psychostimulant drugs cocaine and methylphenidate (ritalin) and studies of the chronic effects of cocaine and of tobacco smoke on the human brain. This chapter concludes with the description of a study which uses brain imaging coupled with a specific pharmacological challenge to address the age-old question of why some people who experiment with drugs become addicted while others do not.

  9. Imaging Antifungal Drug Molecules in Action using Soft X-Ray...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a cell. This use of soft x-ray tomography is now generating considerable interest in the pharmaceutical industry as a potential method for reducing the cost and time it takes to...

  10. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  11. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  12. Imaging Antifungal Drug Molecules in Action using Soft X-Ray Tomography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  13. E-Print Network 3.0 - antifungal activity evaluation Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    used. The antifungal... AccessResearch article Candidaemia and antifungal therapy in a French University Hospital: rough trends... the management of at risk patients as well as...

  14. E-Print Network 3.0 - antifungal immune response Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: requirements to produce the antifungal response and can provide a guide for the design of compounds... the antifungal activity. Carotenuto et al. hypothesized...

  15. E-Print Network 3.0 - antifungal compound produced Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    requirements to produce the antifungal response and can provide a guide for the design of compounds... with this biological activity. Antifungal activity of these compounds...

  16. E-Print Network 3.0 - antifungal compounds produced Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    requirements to produce the antifungal response and can provide a guide for the design of compounds... with this biological activity. Antifungal activity of these compounds...

  17. E-Print Network 3.0 - antifungal compounds enzymatic Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    requirements to produce the antifungal response and can provide a guide for the design of compounds... with this biological activity. Antifungal activity of these compounds...

  18. antifungal susceptibility test: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    antifungal susceptibility test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Antifungal Testing and...

  19. E-Print Network 3.0 - antibiotics antifungal Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Foot) Antiparasitic treatments Antiseptics & wound cleansers Anti... Contraceptives Cough, cold & flu Denture pain relief Digestive aids Ear care Eye care Feminine antifungal &...

  20. E-Print Network 3.0 - antifungal polygalacturonase-inhibiting...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Sample search results for: antifungal polygalacturonase-inhibiting protein Page: << < 1 2 3 4 5 > >> 1 Plant Molecular Biology 53: 357369, 2003. 2003 Kluwer Academic...

  1. Imaging

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  2. E-Print Network 3.0 - antifungal surveillance program Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    interest in using the budding yeast... the discovery of new chemical entities with broad-spectrum antifungal activity.15 Prior to the 1970s... there was little or no demand...

  3. E-Print Network 3.0 - antifungal susceptibilities varieties Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page 1 of 9 Summary: AccessResearch article Candidaemia and antifungal therapy in a French University Hospital: rough trends... the management of at risk patients as well as...

  4. E-Print Network 3.0 - anti-fungal drug design Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: Allergy & sinus medicines and products Feminine anti-fungalanti-itch...

  5. Comparison of Fusion Imaging Using a Combined SPECT/CT System and Intra-arterial CT: Assessment of Drug Distribution by an Implantable Port System in Patients Undergoing Hepatic Arterial Infusion Chemotherapy

    SciTech Connect (OSTI)

    Ikeda, Osamu, E-mail: osamu-3643ik@do9.enjoy.ne.jp; Kusunoki, Shinichiroh; Nakaura, Takeshi; Shiraishi, Shinya; Kawanaka, Kouichi; Tomiguchi, Seiji; Yamashita, Yasuyuki [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, Hiroshi; Chikamoto, Akira; Kanemitsu, Keiichiro [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Gastroenterological Surgery (Japan)

    2006-06-15T23:59:59.000Z

    Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinoma of the liver. We compared the perfusion patterns of HAI chemotherapy on intra-arterial port-catheter computed tomography (iapc-CT) and fused images obtained with a combined single-photon emission computed tomography/computed tomography (SPECT/CT) system. We studied 28 patients with primary or metastatic carcinoma of the liver who bore an implantable HAI port system. All underwent abdominal SPECT using Tc-99m-MAA (185 Mbq); the injection rate was 1 mL/min, identical to the chemotherapy infusion rate, and 0.5 mL/sec for iapc-CT. Delivery was through an implantable port. We compared the intrahepatic perfusion (IHP) and extrahepatic perfusion (EHP) patterns of HAI chemotherapy on iapc-CT images and fused images obtained with a combined SPECT/CT system. In 23 of 28 patients (82%), IHP patterns on iapc-CT images and fused images were identical. In 5 of the 28 patients (18%), IHP on fusion images was different from IHP on iapc-CT images. EHP was seen on fused images in 12 of the 28 patients (43%) and on iapc-CT images in 8 patients (29%). In 17 patients (61%), upper gastrointestinal endoscopy revealed gastroduodenal mucosal lesions. EHP was revealed on fused images in 10 of these patients; 9 of them manifested gastroduodenal toxicity at the time of subsequent HAI chemotherapy. Fusion imaging using the combined SPECT/CT system reflects the actual distribution of the infused anticancer agent. This information is valuable not only for monitoring adequate drug distribution but also for avoiding potential extrahepatic complications.

  6. Imaging

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  7. Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  8. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01T23:59:59.000Z

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  9. Assessment of the activity of antifungal proteins against grain mold in sorghum caryopses in the field

    E-Print Network [OSTI]

    Bueso Ucles, Francisco Javier

    1997-01-01T23:59:59.000Z

    and Chandrashekar 1992, Damettyetal 1993, Seetharamanetal 1996). Chitinases Chitinases have been studied more intensely than any other AFP. They hydrolyze polymers of B-1, 4 acetylglucosamine, chitin, which is unknown in higher plants but is a major component... concentrations at 30 DAA. In Halfway (low mold environment) antifungal proteins (AFP) levels did not decrease from 30 to 50 DAA while they did in CS (with moderate to high mold pressure), suggesting AFP accumulation was affected by mold incidence...

  10. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  11. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  12. Tissue Imaging Using Nanospray Desorption Electrospray Ionization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drug discovery, molecular biology, and biochemistry. Citation: Laskin J, BS Heath, PJ Roach, LH Cazares, and OJ Semmes.2012."Tissue Imaging Using Nanospray Desorption...

  13. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  14. Orthopaedic Implant & Imaging Laboratory Our laboratory is dedicated to exploring the

    E-Print Network [OSTI]

    Berdichevsky, Victor

    on tissue biocompatibility Composite of polymetric, metallic and ceramic materials with drug loading coating with nanoceramic matrix for controlled drug release Molecular and Cellular Imaging PET/CT Imaging

  15. Synthetic Studies of Iriomoteolide-1A Total Synthesis of Alotaketal A and an Antifungal O-Hydroxy-P-Quinone Methide Diterpenoid

    E-Print Network [OSTI]

    Huang, Jinhua

    2013-11-07T23:59:59.000Z

    nuclear PKA signaling in living cells. Our synthetic efforts toward the unnamed quinone methide diterpenoid 1.67 led to the first total synthesis of this potent antifungal product (MIC = 0.19 µM). Our total synthesis was highlighted by a Stille coupling...

  16. Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry

    SciTech Connect (OSTI)

    Sagaram, Uma S.; El-Mounadi, Kaoutar; Buchko, Garry W.; Berg, Howard R.; Kaur, Jagdeep; Pandurangi, Raghoottama; Smith, Thomas J.; Shah, Dilip

    2013-12-04T23:59:59.000Z

    A highly conserved plant defensin MtDef4 potently inhibits the growth of a filamentous fungus Fusarium graminearum. MtDef4 is internalized by cells of F. graminearum. To determine its mechanism of fungal cell entry and antifungal action, NMR solution structure of MtDef4 has been determined. The analysis of its structure has revealed a positively charged patch on the surface of the protein consisting of arginine residues in its ?-core signature, a major determinant of the antifungal activity of MtDef4. Here, we report functional analysis of the RGFRRR motif of the ?-core signature of MtDef4. The replacement of RGFRRR to AAAARR or to RGFRAA not only abolishes fungal cell entry but also results in loss of the antifungal activity of MtDef4. MtDef4 binds strongly to phosphatidic acid (PA), a precursor for the biosynthesis of membrane phospholipids and a signaling lipid known to recruit cytosolic proteins to membranes. Mutations of RGFRRR which abolish fungal cell entry of MtDef4 also impair its binding to PA. Our results suggest that RGFRRR motif is a translocation signal for entry of MtDef4 into fungal cells and that this positively charged motif likely mediates interaction of this defensin with PA as part of its antifungal action.

  17. Developing novel polymer architectures for applications In magnetic resonance imaging and self-assembly

    E-Print Network [OSTI]

    McCombs, Jessica R. (Jessica Rose)

    2013-01-01T23:59:59.000Z

    Macromolecular scaffolds for drug delivery, self-assembly, and imaging applications have attracted significant attention over the last several decades. As polymerization techniques become more sophisticated, it becomes ...

  18. Test Images

    E-Print Network [OSTI]

    Test Images. I hope to have a set of test images for the course soon. Some images are available now; some will have to wait until I can find another 100-200

  19. Imaging Chemical Aggregation of Ni/NiO Particles from Reduced NiO-YSZ. |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt:Imaging AntifungalEMSL

  20. Image Analysis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Recognition Image Analysis and Recognition Snapshot1498121slicesqResedison Fibers permeating imaged material (Courtesy: Bale, Loring, Perciano and Ushizima) Imagery coming from...

  1. Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia

    E-Print Network [OSTI]

    Purdon, Patrick Lee

    It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging ...

  2. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  3. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  4. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  5. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  6. People Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    People Images People Images Several hundred of the 1700 U.S. scientists contributing to the LHC accelerator and experiments gathered in June 2008 in CERN's building 40 CE0252 Joel...

  7. Image alignment

    DOE Patents [OSTI]

    Dowell, Larry Jonathan

    2014-04-22T23:59:59.000Z

    Disclosed is a method and device for aligning at least two digital images. An embodiment may use frequency-domain transforms of small tiles created from each image to identify substantially similar, "distinguishing" features within each of the images, and then align the images together based on the location of the distinguishing features. To accomplish this, an embodiment may create equal sized tile sub-images for each image. A "key" for each tile may be created by performing a frequency-domain transform calculation on each tile. A information-distance difference between each possible pair of tiles on each image may be calculated to identify distinguishing features. From analysis of the information-distance differences of the pairs of tiles, a subset of tiles with high discrimination metrics in relation to other tiles may be located for each image. The subset of distinguishing tiles for each image may then be compared to locate tiles with substantially similar keys and/or information-distance metrics to other tiles of other images. Once similar tiles are located for each image, the images may be aligned in relation to the identified similar tiles.

  8. Computing Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computing Images The interior of an automated tape library in Brookhaven's RHIC and ATLAS Computing Facility. Brookhaven engineers in the RHIC and ATLAS Computing Facility....

  9. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  10. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  11. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, Glen A. (Los Alamos, NM)

    1999-01-01T23:59:59.000Z

    Radiation-hard, steady-state imaging bolometer. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas.

  12. Imaging bolometer

    DOE Patents [OSTI]

    Wurden, G.A.

    1999-01-19T23:59:59.000Z

    Radiation-hard, steady-state imaging bolometer is disclosed. A bolometer employing infrared (IR) imaging of a segmented-matrix absorber of plasma radiation in a cooled-pinhole camera geometry is described. The bolometer design parameters are determined by modeling the temperature of the foils from which the absorbing matrix is fabricated by using a two-dimensional time-dependent solution of the heat conduction equation. The resulting design will give a steady-state bolometry capability, with approximately 100 Hz time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data will be measured via an IR camera. The resulting spatial data may be used to tomographically investigate the profile of plasmas. 2 figs.

  13. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

  14. FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS

    E-Print Network [OSTI]

    Flynn, Colleen A.

    2011-12-31T23:59:59.000Z

    Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

  15. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01T23:59:59.000Z

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  16. Nanometric Optical Imaging Frontiers in Chemical Imaging

    E-Print Network [OSTI]

    Nanometric Optical Imaging Frontiers in Chemical Imaging Seminar Series Presented by... Professor growing field which has provided for nanometric optical imaging in the near-field. Even though a variety of techniques are being developed with nanometric optical imaging potential, near-field optics remains the most

  17. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  18. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab— brand name Yervoy—at $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  19. Chemical Innovation in Drug Dr Matthew Fuchter

    E-Print Network [OSTI]

    Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

  20. The World of Youthful Drug Use

    E-Print Network [OSTI]

    Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

    2000-04-01T23:59:59.000Z

    they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

  1. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  2. E-Print Network 3.0 - adverse antiepileptic drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

  3. Controlling drug delivery across the placenta: A commentary

    E-Print Network [OSTI]

    Audus, Kenneth L.

    1999-01-01T23:59:59.000Z

    A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

  4. WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

  5. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  6. Split image optical display

    DOE Patents [OSTI]

    Veligdan, James T. (Manorville, NY)

    2007-05-29T23:59:59.000Z

    A video image is displayed from an optical panel by splitting the image into a plurality of image components, and then projecting the image components through corresponding portions of the panel to collectively form the image. Depth of the display is correspondingly reduced.

  7. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  8. Drugs and oil flow through the Eagle Ford Shale.

    E-Print Network [OSTI]

    Marks, Michael Perry

    2014-01-01T23:59:59.000Z

    ??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region… (more)

  9. E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  10. antiepileptic drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  11. Food and drug reward: overlapping circuits in human obesity and addiction

    SciTech Connect (OSTI)

    Volkow N. D.; Wang G.; Volkow, N.D.; Wang, G.-J.; Fowler, J.S.; Tomasi, D.; Baler, R.

    2012-12-01T23:59:59.000Z

    Both drug addiction and obesity can be defined as disorders in which the saliency value of one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to, and at the expense of others. This model is consistent with the fact that both drugs and food have powerful reinforcing effects - partly mediated by dopamine increases in the limbic system - that, under certain circumstances or in vulnerable individuals, could overwhelm the brain's homeostatic control mechanisms. Such parallels have generated significant interest in understanding the shared vulnerabilities and trajectories between addiction and obesity. Now, brain imaging discoveries have started to uncover common features between these two conditions and to delineate some of the overlapping brain circuits whose dysfunctions may explain stereotypic and related behavioral deficits in human subjects. These results suggest that both obese and drug addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning (memory/learning), impulse control (behavioral inhibition), stress reactivity and interoceptive awareness. Here, we integrate findings predominantly derived from positron emission tomography that investigate the role of dopamine in drug addiction and in obesity and propose an updated working model to help identify treatment strategies that may benefit both of these conditions.

  12. Femtosecond Transient Imaging

    E-Print Network [OSTI]

    Kirmani, Ahmed (Ghulam Ahmed)

    2010-01-01T23:59:59.000Z

    This thesis proposes a novel framework called transient imaging for image formation and scene understanding through impulse illumination and time images. Using time-of-flight cameras and multi-path analysis of global light ...

  13. Intradermal needle-free powdered drug injection

    E-Print Network [OSTI]

    Liu, John (John Hsiao-Yung)

    2012-01-01T23:59:59.000Z

    This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

  14. Alcohol and Other Drugs Education and Prevention

    E-Print Network [OSTI]

    Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

  15. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  16. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  17. Imaging Sciences Workshop Proceedings

    SciTech Connect (OSTI)

    Candy, J.V.

    1996-11-21T23:59:59.000Z

    This report contains the proceedings of the Imaging Sciences Workshop sponsored by C.A.S.LS., the Center for Advanced Signal & Image Sciences. The Center, established primarily to provide a forum where researchers can freely exchange ideas on the signal and image sciences in a comfortable intellectual environment, has grown over the last two years with the opening of a Reference Library (located in Building 272). The Technical Program for the 1996 Workshop include a variety of efforts in the Imaging Sciences including applications in the Microwave Imaging, highlighted by the Micro-Impulse Radar (MIR) system invented at LLNL, as well as other applications in this area. Special sessions organized by various individuals in Speech, Acoustic Ocean Imaging, Radar Ocean Imaging, Ultrasonic Imaging, and Optical Imaging discuss various applica- tions of real world problems. For the more theoretical, sessions on Imaging Algorithms and Computed Tomography were organized as well as for the more pragmatic featuring a session on Imaging Systems.

  18. NMR imaging of materials

    SciTech Connect (OSTI)

    Listerud, J.M.; Sinton, S.W.; Drobny, G.P.

    1989-01-01T23:59:59.000Z

    Interest in the area of NMR imaging has been driven by the widespread success of medical imaging. John M. Listerud of the Pendergrass Diagnostic Research Laboratories, Steven W. Sinton of Lockheed, and Gary P. Drobny of the University of Washington describe the principal image reconstruction methods, factors limiting spatial resolution, and applications of imaging to the study of materials.

  19. Seismic Imaging and Monitoring

    SciTech Connect (OSTI)

    Huang, Lianjie [Los Alamos National Laboratory

    2012-07-09T23:59:59.000Z

    I give an overview of LANL's capability in seismic imaging and monitoring. I present some seismic imaging and monitoring results, including imaging of complex structures, subsalt imaging of Gulf of Mexico, fault/fracture zone imaging for geothermal exploration at the Jemez pueblo, time-lapse imaging of a walkway vertical seismic profiling data for monitoring CO{sub 2} inject at SACROC, and microseismic event locations for monitoring CO{sub 2} injection at Aneth. These examples demonstrate LANL's high-resolution and high-fidelity seismic imaging and monitoring capabilities.

  20. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  1. Rethinking drug policy: an integrity preserving compromise position

    E-Print Network [OSTI]

    Crispino, Azzurra

    2006-10-30T23:59:59.000Z

    Definition of Drug Types?????????????...??.. 4 2 Definition of Drug Scheduling??????????????. 5 1 CHAPTER I INTRODUCTION TO STATUS QUO DRUG POLICY The issue of how to properly regulate the use of illegal.... Legalizers are those who would make legal all currently illegal drugs. The most 3 common middle stance is that of harm reduction, which is ?an alternative approach to drug policy and treatment that focuses on minimizing the adverse effects of both...

  2. Drug Innovation "Bridging Molecules and Diseases"

    E-Print Network [OSTI]

    Utrecht, Universiteit

    in the pharmaceutical industry. This focus area wishes to provide a knowledge and expertise platform, which platforms with the pharmaceutical industry are presently organized at three different levels: - Strategic, that allows high-level concerted drug research efforts in the molecular sciences, pharmaceutical sciences

  3. Drug smuggling safety tests [July 1, 2006

    E-Print Network [OSTI]

    Suslick, Kenneth S.

    enough to be utilized as drug carriers. Suslick adds that the three tests on mammalian cells they carried evidence of nano safety Login | Register Search: Site X-Ray Page 1 of 2X-Ray - Your Guide to All the Key X About Us | Contact Us | Privacy Policy | Terms & Conditions | Advertising | RSS Interested

  4. Imaging in radiotherapy

    SciTech Connect (OSTI)

    Taylor, J.

    1987-01-01T23:59:59.000Z

    The text contains details of recording media, image quality, sensitometry, processing and equipment used in radiotherapy for imaging. It reflects part of the syllabus for the College of Radiographers.

  5. User Science Images

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Image: OBrianImageBig.png | png | 5 MB SlavaFull.png FES: Small Scale Experimental Plasma Research October 21, 2010 | Author(s): Vyacheslav Lukin (NRL) | Category: Fusion Energy |...

  6. Dual Plane Imaging

    E-Print Network [OSTI]

    Parry, Ian

    2015-01-01T23:59:59.000Z

    We outline a technique called Dual Plane Imaging which should significantly improve images which would otherwise be blurred due to atmospheric turbulence. The technique involves capturing all the spatial, directional and temporal information about the arriving photons and processing the data afterwards to produce the sharpened images. The technique has particular relevance for imaging at around 400-1000nm on extremely large telescopes (ELTs).

  7. Consumers' Image of Broilers.

    E-Print Network [OSTI]

    Courtenay, Henry V.; Branson, Robert E.

    1962-01-01T23:59:59.000Z

    which they feel the product possesses. This research was designed to determine consumers' favorable and unfavorable images as to broilers, both in making purchases in stores and in serving them as a meat dish. These images, summarized briefly here... count. The Preparation and Cooking Image: The h0u.l wife's image of broilers focuses on one metliotl- frying. The major deterrent to preparing othci dishes was that these are either too difficult or canno* be prepared satisfactorily...

  8. Imaging with Scattered Neutrons

    E-Print Network [OSTI]

    H. Ballhausen; H. Abele; R. Gaehler; M. Trapp; A. Van Overberghe

    2006-10-30T23:59:59.000Z

    We describe a novel experimental technique for neutron imaging with scattered neutrons. These scattered neutrons are of interest for condensed matter physics, because they permit to reveal the local distribution of incoherent and coherent scattering within a sample. In contrast to standard attenuation based imaging, scattered neutron imaging distinguishes between the scattering cross section and the total attenuation cross section including absorption. First successful low-noise millimeter-resolution images by scattered neutron radiography and tomography are presented.

  9. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V

    2013-06-25T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

  10. Magnetic Imaging Wolfgang Kuch

    E-Print Network [OSTI]

    Kuch, Wolfgang

    Magnetic Imaging Wolfgang Kuch Freie Universit¨at Berlin, Institut f¨ur Experimentalphysik, Arnimallee 14, 14195 Berlin, Germany kuch@physik.fu-berlin.de Abstract. Imaging of magnetic domains has- ern techniques is used nowadays routinely for magnetic imaging of magnetic ma- terials

  11. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

  12. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

  13. Near-electrode imager

    DOE Patents [OSTI]

    Rathke, Jerome W. (Lockport, IL); Klingler, Robert J. (Westmont, IL); Woelk, Klaus (Wachtberg, DE); Gerald, II, Rex E. (Brookfield, IL)

    2000-01-01T23:59:59.000Z

    An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager uses the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

  14. Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Laskin, Julia; Heath, Brandi S.; Roach, Patrick J.; Cazares, Lisa H.; Semmes, O. John

    2012-01-03T23:59:59.000Z

    We present the first results showing the ambient imaging of biological samples in their native environment using nanospray desorption ionization (nanoDESI) mass spectrometry. NanoDESI is an ambient pressure ionization technique that enables precise control of ionization of molecules from substrates. We demonstrate highly sensitive and robust analysis of tissue samples with high spatial resolution (<12 {mu}m) without sample preparation, which will be essential for applications in clinical diagnostics, drug discovery, molecular biology, and biochemistry.

  15. Automation in image cytometry : continuous HCS and kinetic image cytometry

    E-Print Network [OSTI]

    Charlot, David J.

    2012-01-01T23:59:59.000Z

    OF CALIFORNIA, SAN DIEGO Automation in Image Cytometry:xiv Abstract of Dissertation Automation in Image Cytometry:

  16. Alignment strategies for drug product process development and manufacturing

    E-Print Network [OSTI]

    Garvin, Christopher John

    2012-01-01T23:59:59.000Z

    The transfer of information between the drug product development and manufacturing organizations is fundamental to drug product commercialization. This information is used to characterize the product-process interaction ...

  17. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  18. Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs

    E-Print Network [OSTI]

    Stauber, Zachary Jason

    2012-01-01T23:59:59.000Z

    Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

  19. Research paper Drug diffusion and binding in ionizable interpenetrating networks

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

  20. High throughput optical sensor arrays for drug screening

    E-Print Network [OSTI]

    Harjes, Daniel I

    2006-01-01T23:59:59.000Z

    In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

  1. Luminal flow amplifies stent-based drug deposition in arterial

    E-Print Network [OSTI]

    Levine, Evan G.

    Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ...

  2. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01T23:59:59.000Z

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  3. Attitudes toward the integration of smoking cessation treatment into drug abuse clinics.

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Direct Care Workforce in the National Drug Abuse Treatmentdependence treatment into drug abuse care reduces thesecare settings but not yet in independent drug abuse treatment

  4. E-Print Network 3.0 - arv drug patents Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... country Generic name Non proprietary, same...

  5. E-Print Network 3.0 - anticancer drug levels Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chemistry 7 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- Summary: is responsible for metabol- ism of drug B. Such drug...

  6. E-Print Network 3.0 - anticancer drug topotecan Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  7. E-Print Network 3.0 - anticancer drug combretastatin-a2 Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  8. E-Print Network 3.0 - anticancer drug oracin Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  9. E-Print Network 3.0 - anticancer drugs mitoxantrone Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  10. E-Print Network 3.0 - anticancer drug roscovitine Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  11. E-Print Network 3.0 - anticancer drug mitoxantrone Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    significant drug-drug interactions be- tween oral anticancer agents and nonanti-cancer agents... Oxford University Press 2005 1 Category Discovering drug interactions: a...

  12. E-Print Network 3.0 - antiretroviral drugs arvs Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (ARV) drugs except... . Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug... 1 Early loss to program in HIV-infected ......

  13. E-Print Network 3.0 - analyzing drug combination Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    , Saadat Anwar2 , Shanshan Liang2... : Identifying drug-drug interactions is a critical process in drug administration and ... Source: Baral, Chitta - Department of Computer...

  14. E-Print Network 3.0 - antiviral drug resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Opin Emerg Drugs . Author manuscript Emerging drugs for hepatitis B Summary: and to design new trials of combination therapy to delay drug resistance. In the future, antiviral...

  15. Proper Usage of Drugs and Chemicals in Food Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2002-02-15T23:59:59.000Z

    of omission or commission, violative residues in livestock and poultry (by irresponsible and illegal distribution and use of drugs) violates state and federal laws. When FSIS inspectors detect violative drug residues in food products derived from ani- mals... quality ani- mal food products. Extra-label distribution, prescription and use of veterinary drugs in food producing animals are reg- ulated by FDA. The FDA policy requires all extra- label drug usage to be under the control of a licensed veterinarian...

  16. Model-Based Dependability Analysis of Programmable Drug Infusion Pumps

    E-Print Network [OSTI]

    Sankaranarayanan, Sriram

    Model-Based Dependability Analysis of Programmable Drug Infusion Pumps Sriram Sankaranarayanan.lastname@colorado.edu Abstract. Infusion pumps are commonly used in home/hospital care to inject drugs into a patient a case-study involving an infusion pump used to manage pain through the infusion of analgesic drugs

  17. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-07-29T23:59:59.000Z

    The order provides guidance and policy for the administration, application and implementation of the DOE Drug-free Federal Workplace Plan and other regulations that facilitate the maintenance of a drug-free Federal workplace through the establishment of programs to test for the use of illegal drugs. Chg 1, dated 8-21-92

  18. Aerosolized Delivery of Antifungal Agents

    E-Print Network [OSTI]

    Le, Jennifer; Schiller, Daryl S.

    2010-01-01T23:59:59.000Z

    toxicities, such as cough, which is a common adverse effecttension, can greatly influence the occurrence of cough.Induction of cough can occur when the osmolality is less

  19. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  20. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  1. From the Frontlines to the Bottom Line: Medical Marijuana, the War on Drugs, and the Drug Policy Reform Movement

    E-Print Network [OSTI]

    Heddleston, Thomas Reed

    2012-01-01T23:59:59.000Z

    reputation-2009-2). Carter, Jimmy. 1977. “Drug Abuse Messagea presidential candidate in 1976, Jimmy Carter even adopted

  2. Image compression technique

    DOE Patents [OSTI]

    Fu, C.Y.; Petrich, L.I.

    1997-03-25T23:59:59.000Z

    An image is compressed by identifying edge pixels of the image; creating a filled edge array of pixels each of the pixels in the filled edge array which corresponds to an edge pixel having a value equal to the value of a pixel of the image array selected in response to the edge pixel, and each of the pixels in the filled edge array which does not correspond to an edge pixel having a value which is a weighted average of the values of surrounding pixels in the filled edge array which do correspond to edge pixels; and subtracting the filled edge array from the image array to create a difference array. The edge file and the difference array are then separately compressed and transmitted or stored. The original image is later reconstructed by creating a preliminary array in response to the received edge file, and adding the preliminary array to the received difference array. Filling is accomplished by solving Laplace`s equation using a multi-grid technique. Contour and difference file coding techniques also are described. The techniques can be used in a method for processing a plurality of images by selecting a respective compression approach for each image, compressing each of the images according to the compression approach selected, and transmitting each of the images as compressed, in correspondence with an indication of the approach selected for the image. 16 figs.

  3. Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Seto, Jennifer Elizabeth

    2011-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

  4. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Thomas, Mathew; Carson, James P.; Smith, Jordan N.; Timchalk, Charles; Laskin, Julia

    2013-01-15T23:59:59.000Z

    Imaging mass spectrometry offers simultaneous detection of drugs, drug metabolites and endogenous substances in a single experiment. This is important when evaluating effects of a drug on a complex organ system such as the brain, where there is a need to understand how regional drug distribution impacts function. Nicotine is an addictive drug and its action in the brain is of high interest. Here we use nanospray desorption electrospray ionization, nano-DESI, imaging to discover the localization of nicotine in rat brain tissue after in vivo administration of nicotine. Nano-DESI is a new ambient technique that enables spatially-resolved analysis of tissue samples without special sample pretreatment. We demonstrate high sensitivity of nano-DESI imaging that enables detection of only 0.7 fmole nicotine per pixel in the complex brain matrix. Furthermore, by adding deuterated nicotine to the solvent, we examined how matrix effects, ion suppression, and normalization affect the observed nicotine distribution. Finally, we provide preliminary results suggesting that nicotine localizes to the hippocampal substructure called dentate gyrus.

  5. Video Toroid Cavity Imager

    DOE Patents [OSTI]

    Gerald, Rex E. II; Sanchez, Jairo; Rathke, Jerome W.

    2004-08-10T23:59:59.000Z

    A video toroid cavity imager for in situ measurement of electrochemical properties of an electrolytic material sample includes a cylindrical toroid cavity resonator containing the sample and employs NMR and video imaging for providing high-resolution spectral and visual information of molecular characteristics of the sample on a real-time basis. A large magnetic field is applied to the sample under controlled temperature and pressure conditions to simultaneously provide NMR spectroscopy and video imaging capabilities for investigating electrochemical transformations of materials or the evolution of long-range molecular aggregation during cooling of hydrocarbon melts. The video toroid cavity imager includes a miniature commercial video camera with an adjustable lens, a modified compression coin cell imager with a fiat circular principal detector element, and a sample mounted on a transparent circular glass disk, and provides NMR information as well as a video image of a sample, such as a polymer film, with micrometer resolution.

  6. Extension of the Isobolographic Approach to Interactions Studies between More than Two Drugs: Illustration

    E-Print Network [OSTI]

    Gelman, Andrew

    received the drugs separately or in various combinations. Drug infusion was stopped at the onset of maximal

  7. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, David N. (San Antonio, TX); Kiel, Johnathan L. (San Antonio, TX); Batishko, Charles R. (West Richland, WA); Stahl, Kurt A. (Richland, WA)

    1990-01-01T23:59:59.000Z

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.

  8. Quantitative luminescence imaging system

    DOE Patents [OSTI]

    Erwin, D.N.; Kiel, J.L.; Batishko, C.R.; Stahl, K.A.

    1990-08-14T23:59:59.000Z

    The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopic imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber. 22 figs.

  9. Ferroelectric optical image comparator

    DOE Patents [OSTI]

    Butler, M.A.; Land, C.E.; Martin, S.J.; Pfeifer, K.B.

    1993-11-30T23:59:59.000Z

    A ferroelectric optical image comparator has a lead lanthanum zirconate titanate thin-film device which is constructed with a semi-transparent or transparent conductive first electrode on one side of the thin film, a conductive metal second electrode on the other side of the thin film, and the second electrode is in contact with a nonconducting substrate. A photoinduced current in the device represents the dot product between a stored image and an image projected onto the first electrode. One-dimensional autocorrelations are performed by measuring this current while displacing the projected image. 7 figures.

  10. EMSL - image superimposition

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    image-superimposition en Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. http:www.emsl.pnl.govemslwebpublicationsmagnesium-behavior-and-structu...

  11. image superimposition | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superimposition image superimposition Leads No leads are available at this time. Magnesium behavior and structural defects in Mg+ ion implanted silicon carbide. Abstract: As a...

  12. A CMOS contact imager for locating individual Honghao Ji, David Sander, Alfred Haas, Pamela A. Abshire

    E-Print Network [OSTI]

    Maryland at College Park, University of

    to the background illumination. The imager is capable of locating dark objects in a bright background or bright objects in a dark background. The loca- tions of recognized cells are generated as outputs to alleviate of intracel- lular processes, drug development, medical diagnostics, and the development of cell-based sensors

  13. Restoring functional PET Images using Anatomical MR Images

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Restoring functional PET Images using Anatomical MR Images Peter Philipsen, Ulrik Kjems, Peter Toft signal to noise ratio and the low spa­ tial resolution in Positron Emission Tomography (PET) images ? And Positron Emission Tomography (PET) Images? ffl Segmentation of MR Images ­ Extraction of important edges

  14. Compression of Computer Graphics Images with Image-Based Rendering

    E-Print Network [OSTI]

    Shahabi, Cyrus

    Compression of Computer Graphics Images with Image-Based Rendering Ilmi Yoon and Ulrich Neumann information from previously rendered images. Images predicted from prior images are combined with a residual-based rendering tech- nique provides accurate motion prediction and accelerates rendering at the same time

  15. SciTech Connect: Drug Retention Times

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systems controllerAdditiveBetatronAerogelDistances fromUsage SystemDrug

  16. DRUG TESING PANEL & CUTOFF CONCENTRATIONS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganizationElectronic2005-2007 Budget Dear2, 2011DREAM toolDRUG

  17. DOUBLE MAJORS Imaging Science + ...

    E-Print Network [OSTI]

    Zanibbi, Richard

    DOUBLE MAJORS Imaging Science + ... Applied Mathematics Biomedical Sciences Computer Science Undergraduate Research Internships and Cooperative Education (Co-op) (optional) Study Abroad WHY IMAGING SCIENCE Science: BS, MS, PhD Color Science: MS, PhD BS + MS/PhD Combos HUMAN VISION BIO- MEDICAL ASTRO- PHYSICS

  18. Directional Multiresolution Image Representations

    E-Print Network [OSTI]

    Do, Minh N.

    ) are not necessarily best suited for images. Thus, there is a strong motivation to search for more powerful schemes consid´er´ees comme de bonnes repr´esentations des images na- turelles. Le lien entre les courbelettes et

  19. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2012-07-24T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

  20. Heart imaging method

    DOE Patents [OSTI]

    Collins, H. Dale (Richland, WA); Gribble, R. Parks (Richland, WA); Busse, Lawrence J. (Littleton, CO)

    1991-01-01T23:59:59.000Z

    A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.

  1. Fluorescent image tracking velocimeter

    DOE Patents [OSTI]

    Shaffer, Franklin D. (Library, PA)

    1994-01-01T23:59:59.000Z

    A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

  2. Adaptive wiener image restoration kernel

    DOE Patents [OSTI]

    Yuan, Ding (Henderson, NV)

    2007-06-05T23:59:59.000Z

    A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

  3. Time encoded radiation imaging

    DOE Patents [OSTI]

    Marleau, Peter; Brubaker, Erik; Kiff, Scott

    2014-10-21T23:59:59.000Z

    The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

  4. Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem

    E-Print Network [OSTI]

    Wu, Mingshen

    Alcohol, Drugs, and Accident Prevention (RC-371/-571) Course Description The role of alcohol and drugs and their relationship to accident causation will be examined. The problem of alcoholism and drug

  5. Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery

    E-Print Network [OSTI]

    Bagby, Taryn Rochelle

    2011-12-31T23:59:59.000Z

    Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

  6. Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery

    E-Print Network [OSTI]

    Ghosh, Debadyuti

    M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

  7. Polarization transfer NMR imaging

    DOE Patents [OSTI]

    Sillerud, Laurel O. (Los Alamos, NM); van Hulsteyn, David B. (Santa Fe, NM)

    1990-01-01T23:59:59.000Z

    A nuclear magnetic resonance (NMR) image is obtained with spatial information modulated by chemical information. The modulation is obtained through polarization transfer from a first element representing the desired chemical, or functional, information, which is covalently bonded and spin-spin coupled with a second element effective to provide the imaging data. First and second rf pulses are provided at first and second frequencies for exciting the imaging and functional elements, with imaging gradients applied therebetween to spatially separate the nuclei response for imaging. The second rf pulse is applied at a time after the first pulse which is the inverse of the spin coupling constant to select the transfer element nuclei which are spin coupled to the functional element nuclei for imaging. In a particular application, compounds such as glucose, lactate, or lactose, can be labeled with .sup.13 C and metabolic processes involving the compounds can be imaged with the sensitivity of .sup.1 H and the selectivity of .sup.13 C.

  8. antidepressant drug treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    prognosis. ... Scott, Alexander Wesley 2010-01-01 50 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  9. antiretroviral drug exposure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SKILLS AQUIRED THROUGH Auerbach, Scott M. 2 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  10. antiretroviral drug combination: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    carrying various combinations Ahlers, Guenter 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  11. antidepressant drug design: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ylenedioxymethamphetamine (MDMA) also known as Ecstasy is a common recreational drug of abuse and reports of abuse of tricyclic antidepressants are also known. We report two cases...

  12. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01T23:59:59.000Z

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  13. In silico modeling to predict drug-induced phospholipidosis

    SciTech Connect (OSTI)

    Choi, Sydney S.; Kim, Jae S.; Valerio, Luis G., E-mail: luis.valerio@fda.hhs.gov; Sadrieh, Nakissa

    2013-06-01T23:59:59.000Z

    Drug-induced phospholipidosis (DIPL) is a preclinical finding during pharmaceutical drug development that has implications on the course of drug development and regulatory safety review. A principal characteristic of drugs inducing DIPL is known to be a cationic amphiphilic structure. This provides evidence for a structure-based explanation and opportunity to analyze properties and structures of drugs with the histopathologic findings for DIPL. In previous work from the FDA, in silico quantitative structure–activity relationship (QSAR) modeling using machine learning approaches has shown promise with a large dataset of drugs but included unconfirmed data as well. In this study, we report the construction and validation of a battery of complementary in silico QSAR models using the FDA's updated database on phospholipidosis, new algorithms and predictive technologies, and in particular, we address high performance with a high-confidence dataset. The results of our modeling for DIPL include rigorous external validation tests showing 80–81% concordance. Furthermore, the predictive performance characteristics include models with high sensitivity and specificity, in most cases above ? 80% leading to desired high negative and positive predictivity. These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL. - Highlights: • New in silico models for predicting drug-induced phospholipidosis (DIPL) are described. • The training set data in the models is derived from the FDA's phospholipidosis database. • We find excellent predictivity values of the models based on external validation. • The models can support drug screening and regulatory decision-making on DIPL.

  14. Unlocking enzyme synthesis of rare sugars to create drugs with...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    this study is to dramatically improve the performance of enzymes that can be used by the pharmaceutical industry to synthesize drug precursors," said ORNL's Andrey Kovalevsky, the...

  15. antimalarial drug artemisinin: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Isolation of Artemisinin as Antimalarial Drugs from Artemisia annua L. Cultivated in Indonesia CiteSeer Summary: Abstract-- Malaria disease is endemic in developing countries like...

  16. act drug policies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcoholic beverages. These standards conform to state and federal laws. The policy described in this brochure pertains to alcohol and other drug use behaviors in...

  17. antithyroid drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  18. antidiabetic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  19. antiretroviral drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  20. antipsychotic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  1. adverse drug events: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  2. adverse drug event: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  3. antiepileptic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  4. antiarrhythmic drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  5. acute drug intoxication: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  6. adhd drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  7. antihypertensive drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  8. Transdermal microconduits by microscission for drug delivery and sample acquisition

    E-Print Network [OSTI]

    Gonzalez, Salvador

    Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

  9. Food and Drug Administration White Oak Campus Environmental Stewardshi...

    Broader source: Energy.gov (indexed) [DOE]

    FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus. espcsswhiteoak.pdf More Documents & Publications Energy...

  10. antimalarial drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 30 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  11. antidepressant drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 39 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  12. avoiding drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the solubility data supporting intended decision-making? 12;Tablet Tipple, Brett 23 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  13. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

    1983-03-11T23:59:59.000Z

    It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

  14. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  15. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  16. Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture

    DOE Patents [OSTI]

    Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S.

    2013-01-08T23:59:59.000Z

    Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates.

  17. Photothermal imaging scanning microscopy

    DOE Patents [OSTI]

    Chinn, Diane (Pleasanton, CA); Stolz, Christopher J. (Lathrop, CA); Wu, Zhouling (Pleasanton, CA); Huber, Robert (Discovery Bay, CA); Weinzapfel, Carolyn (Tracy, CA)

    2006-07-11T23:59:59.000Z

    Photothermal Imaging Scanning Microscopy produces a rapid, thermal-based, non-destructive characterization apparatus. Also, a photothermal characterization method of surface and subsurface features includes micron and nanoscale spatial resolution of meter-sized optical materials.

  18. JOB OPPORTUNITIES Breast imaging

    E-Print Network [OSTI]

    Jiang, Huiqiang

    Genitourinary Radiology Head and Neck Radiology Musculoskeletal Radiology Neuroradiology Pediatric RadiologyJOB OPPORTUNITIES Breast imaging Chest Radiology Emergency Radiology Gastrointestinal Radiology Interventional Radiology Nuclear Radiology Radiation Oncology What Can I Do With a Major in... Radiological

  19. THERMAL NEUTRON BACKSCATTER IMAGING.

    SciTech Connect (OSTI)

    VANIER,P.; FORMAN,L.; HUNTER,S.; HARRIS,E.; SMITH,G.

    2004-10-16T23:59:59.000Z

    Objects of various shapes, with some appreciable hydrogen content, were exposed to fast neutrons from a pulsed D-T generator, resulting in a partially-moderated spectrum of backscattered neutrons. The thermal component of the backscatter was used to form images of the objects by means of a coded aperture thermal neutron imaging system. Timing signals from the neutron generator were used to gate the detection system so as to record only events consistent with thermal neutrons traveling the distance between the target and the detector. It was shown that this time-of-flight method provided a significant improvement in image contrast compared to counting all events detected by the position-sensitive {sup 3}He proportional chamber used in the imager. The technique may have application in the detection and shape-determination of land mines, particularly non-metallic types.

  20. Overview of Image Reconstruction

    SciTech Connect (OSTI)

    Marr, R.B.

    1980-04-01T23:59:59.000Z

    Image reconstruction (or computerized tomography, etc.) is any process whereby a function, f, on Rn is estimated from empirical data pertaining to its integrals, ∫f(x) dx, for some collection of hyperplanes of dimension k < n. The paper begins with background information on how image reconstruction problems have arisen in practice, and describes some of the application areas of past or current interest; these include radioastronomy, optics, radiology and nuclear medicine, electron microscopy, acoustical imaging, geophysical tomography, nondestructive testing, and NMR zeugmatography. Then the various reconstruction algorithms are discussed in five classes: summation, or simple back-projection; convolution, or filtered back-projection; Fourier and other functional transforms; orthogonal function series expansion; and iterative methods. Certain more technical mathematical aspects of image reconstruction are considered from the standpoint of uniqueness, consistency, and stability of solution. The paper concludes by presenting certain open problems. 73 references. (RWR)

  1. Reflective optical imaging system

    DOE Patents [OSTI]

    Shafer, David R. (Fairfield, CT)

    2000-01-01T23:59:59.000Z

    An optical system compatible with short wavelength (extreme ultraviolet) radiation comprising four reflective elements for projecting a mask image onto a substrate. The four optical elements are characterized in order from object to image as convex, concave, convex and concave mirrors. The optical system is particularly suited for step and scan lithography methods. The invention increases the slit dimensions associated with ringfield scanning optics, improves wafer throughput and allows higher semiconductor device density.

  2. Restoring functional PET Images using Anatomical MR Images

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Restoring functional PET Images using Anatomical MR Images Peter Alshede Philipsen, Ulrik Kjems,uk,pto,lkh@imm.dtu.dk Abstract In this paper we present a Bayesian method to enhance functional 3D PET images using apriori as a true PET­MR result, and further more show how to obtain the desired information from the MR images. 1

  3. Drug-Free Federal Workplace Testing Implementation Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-06T23:59:59.000Z

    The subject directive provides requirements and responsibilities for the implementation of a workplace program to test for the use of illegal drugs to facilitate the maintenance of a drug-free Federal workplace. In the course of the revision, the document number will change from DOE O 3792.3 to DOE O 343.1.

  4. ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY

    E-Print Network [OSTI]

    are more related to the kind of cancer than to drug activity patterns. Dependency analysis using Bayesian1 11 ANALYSIS OF GENE EXPRESSION PROFILES AND DRUG ACTIVITY PATTERNS BY CLUSTERING AND BAYESIAN of data produced from up- to-date biological experimental processes needs appropriate data mining

  5. Identifying novel drug indications through automated reasoning Authors and Affiliations

    E-Print Network [OSTI]

    Baral, Chitta

    of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

  6. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  7. Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List

    E-Print Network [OSTI]

    Oklahoma, University of

    Blue MedicareRx (PDP)SM 2012 Comprehensive Drug List PLEASE READ: THIS DOCUMENT CONTAINS DrugList Blue MedicareRx (PDP)SM 2012 Formulary (List of Covered Drugs) DrugList PLEASE READ. Blue MedicareRx (PDP) is a stand-alone prescription drug plan with a Medicare contract offered by HCSC

  8. An alternative approach based on microfluidics to study drug metabolism and toxicity using liver and intestinal tissue.

    E-Print Network [OSTI]

    Midwoud, Paul Marcel van

    2010-01-01T23:59:59.000Z

    ??A new in vitro system has been developed to study drug metabolism, drug-drug interactions and interorgan communication. As the ultimate goal was a system which… (more)

  9. Multispectral imaging probe

    DOE Patents [OSTI]

    Sandison, David R. (Moriarty, NM); Platzbecker, Mark R. (Albuquerque, NM); Descour, Michael R. (Tucson, AZ); Armour, David L. (Albuquerque, NM); Craig, Marcus J. (Albuquerque, NM); Richards-Kortum, Rebecca (Austin, TX)

    1999-01-01T23:59:59.000Z

    A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector.

  10. Multispectral imaging probe

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Descour, M.R.; Armour, D.L.; Craig, M.J.; Richards-Kortum, R.

    1999-07-27T23:59:59.000Z

    A multispectral imaging probe delivers a range of wavelengths of excitation light to a target and collects a range of expressed light wavelengths. The multispectral imaging probe is adapted for mobile use and use in confined spaces, and is sealed against the effects of hostile environments. The multispectral imaging probe comprises a housing that defines a sealed volume that is substantially sealed from the surrounding environment. A beam splitting device mounts within the sealed volume. Excitation light is directed to the beam splitting device, which directs the excitation light to a target. Expressed light from the target reaches the beam splitting device along a path coaxial with the path traveled by the excitation light from the beam splitting device to the target. The beam splitting device directs expressed light to a collection subsystem for delivery to a detector. 8 figs.

  11. Variable waveband infrared imager

    DOE Patents [OSTI]

    Hunter, Scott R.

    2013-06-11T23:59:59.000Z

    A waveband imager includes an imaging pixel that utilizes photon tunneling with a thermally actuated bimorph structure to convert infrared radiation to visible radiation. Infrared radiation passes through a transparent substrate and is absorbed by a bimorph structure formed with a pixel plate. The absorption generates heat which deflects the bimorph structure and pixel plate towards the substrate and into an evanescent electric field generated by light propagating through the substrate. Penetration of the bimorph structure and pixel plate into the evanescent electric field allows a portion of the visible wavelengths propagating through the substrate to tunnel through the substrate, bimorph structure, and/or pixel plate as visible radiation that is proportional to the intensity of the incident infrared radiation. This converted visible radiation may be superimposed over visible wavelengths passed through the imaging pixel.

  12. 3/3/14 9:05 AMLive Feed into Our Bodies, University of California Santa Barbara | National Institute of Biomedical Imaging and Bioengineering Page 1 of 1http://www.nibib.nih.gov/news-events/newsroom/live-feed-our-bodies-university-california-santa-barbara

    E-Print Network [OSTI]

    Bigelow, Stephen

    Institute of Biomedical Imaging and Bioengineering Page 1 of 1http://www.nibib.nih.gov/news-events; Platform Technologies Health Terms: Drug Delivery, Medical Devices Contact nibibpress@mail.nih.gov 301

  13. E-Print Network 3.0 - antiepileptic drug resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ashwin Kumaria & Christos M. Tolias & Summary: have been shown to underlie seizures, and conventional antiepileptic drugs have been shown to attenuate... for antiepileptic drugs....

  14. E-Print Network 3.0 - amplifies stent-based drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    IN STENT-BASED DRUG DELIVERY Giuseppe Pontrelli*, Filippo de Monte** *IAC... . Hwang, D. Wu, E.R. Edelman, Physiological transport forces govern drug...

  15. E-Print Network 3.0 - antipsychotic drug ykp1358 Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Idle, J.R. (1997). Antipsychotic drug-induced movement disorders... Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

  16. E-Print Network 3.0 - active drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Clinic to introduce students to drug delivery, and in a senior-level elective... of the pharmaceutical industry today, with new drug ... Source: Hesketh, Robert - College of...

  17. E-Print Network 3.0 - antimicrobial drug discovery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    skills in drug discovery, drug development, and clinical care to enter a career... in the pharmaceutical industry, in pharmaceutical development extending from ... Source: Abagyan,...

  18. E-Print Network 3.0 - advanced drug design Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to this problem could be from rational drug design using Bioinformatics. The focus of the pharmaceutical industry... design. A successful and reliable drug design process could...

  19. E-Print Network 3.0 - advanced drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nano-biomaterials, pharmaceuticals and drug delivery. They are exploring numerous... the pharmaceutical industry--the PTRC has created a novel inhaled drug delivery method that...

  20. E-Print Network 3.0 - antimalarial drug discovery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    REVIEWS | DRUG DISCOVERY VOLUME 3 | JUNE 2004 | 509 Summary: . Croft , Reto Brun|| and Solomon Nwaka Increased efforts in antimalarial drug discovery are urgently... for...

  1. E-Print Network 3.0 - animal drugs change Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biology and Medicine ; Environmental Sciences and Ecology 3 RESOLUTION ON THE USE OF CHEMICALS AND DRUGS IN AQUACULTURE Summary: Investigational New Animal Drug (INAD) permits and...

  2. E-Print Network 3.0 - anticancer drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized program in drug design and discovery...

  3. E-Print Network 3.0 - anticancer drug analysis Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    products, can have antibiotic, anticancer, anticholesterolemic... , and other activities that make them useful as drugs or drug leads for the treatment ... Source: New...

  4. E-Print Network 3.0 - anticancer drug development Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized program in drug design and discovery...

  5. E-Print Network 3.0 - artery disease drugs Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drug Plan Benefit Guide Revised 101510 Summary: artery disease or congestive heart failure) are eligible for the Value-Based Prescription Drug Plan... (Coronary Artery...

  6. E-Print Network 3.0 - antirheumatic drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    elderly: Pharmacy data as a tool for improvement Summary: Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997... for Drug...

  7. E-Print Network 3.0 - antiparasital drug benznidazole Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  8. E-Print Network 3.0 - acute cutaneous drug Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Dundee Collection: Biology and Medicine 72 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: -inflammatory drugs are often...

  9. E-Print Network 3.0 - alternative drug interaction Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematics 69 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

  10. E-Print Network 3.0 - antithyroid drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science 57 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

  11. E-Print Network 3.0 - anti-rheumatic drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science 91 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

  12. E-Print Network 3.0 - anti-tuberculosis drugs induced Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drugs induced Page: << < 1 2 3 4 5 > >> 1 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

  13. E-Print Network 3.0 - assessing drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematics 28 Summary and future perspectives Numerous publications identify that gout management is often sub-optimal, despite detailed Summary: -morbidities and drug- drug...

  14. E-Print Network 3.0 - arsenic-based antineoplastic drugs Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Occupational Exposures to Antineoplastic and Other Hazardous Drugs in Health Care Settings" (http... Group 1 Carcinogens, Chemotherapy Waste and other Hazardous Drug...

  15. E-Print Network 3.0 - antiparasitic drug nitazoxanide Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  16. E-Print Network 3.0 - antiinflammatory drug chemistry Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drug chemistry Search Powered by Explorit Topic List Advanced Search Sample search results for: antiinflammatory drug chemistry Page: << < 1 2 3 4 5 > >> 1 Novel Anti-Inflammatory...

  17. E-Print Network 3.0 - anticancer drug pump Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

  18. \\NeuroImage" Informatics

    E-Print Network [OSTI]

    Nielsen, Finn Ă?rup

    International Neuroimaging Consortium Introduction Author cocitation analysis describes a scienti#12;c #12;eld on data collected by the Institute of Scien- ti#12;c Information among a limited set of key au- thors within a #12;eld. Here we work on data from a single journal (the journal \\NeuroImage") down- loaded from

  19. EBSD Images Theoretical Background

    E-Print Network [OSTI]

    Candea, George

    Motivation EBSD Images Theoretical Background Defects in the Weld Grain Growth Low Speed Welding High Speed Welding Conclusion Heat-Affected Zone Observations Welding Experiments The low density in the transportation industries. Reproducibility and the low cost make welding a major large scale assembly process

  20. Image Charge Differential

    E-Print Network [OSTI]

    Weston, Ken

    Image Charge Differential Amplifier FT 0 Crude Oil Time (s) 543210 Frequency (kHz) m/z m q B f Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) uses the frequency of cyclotron motion of the ions in a static magnetic field to determine the mass-to-charge ratio, which is then used

  1. Fundamentals of Image Processing

    E-Print Network [OSTI]

    Erdem, Erkut

    Fourier transform Log power spectrum #12;Review - The Convolution Theorem · The Fourier transform components · Fourier (1807): Periodic functions could be represented as a weighted sum of sines and cosines Image courtesy of Technology Review #12;Review - Fourier Transform We want to understand

  2. Time-Encoded Imagers.

    SciTech Connect (OSTI)

    Marleau, Peter; Brubaker, Erik

    2014-11-01T23:59:59.000Z

    This report provides a short overview of the DNN R&D funded project, Time-Encoded Imagers. The project began in FY11 and concluded in FY14. The Project Description below provides the overall motivation and objectives for the project as well as a summary of programmatic direction. It is followed by a short description of each task and the resulting deliverables.

  3. Image Reconstruction for Prostate Specific Nuclear Medicine imagers

    SciTech Connect (OSTI)

    Mark Smith

    2007-01-11T23:59:59.000Z

    There is increasing interest in the design and construction of nuclear medicine detectors for dedicated prostate imaging. These include detectors designed for imaging the biodistribution of radiopharmaceuticals labeled with single gamma as well as positron-emitting radionuclides. New detectors and acquisition geometries present challenges and opportunities for image reconstruction. In this contribution various strategies for image reconstruction for these special purpose imagers are reviewed. Iterative statistical algorithms provide a framework for reconstructing prostate images from a wide variety of detectors and acquisition geometries for PET and SPECT. The key to their success is modeling the physics of photon transport and data acquisition and the Poisson statistics of nuclear decay. Analytic image reconstruction methods can be fast and are useful for favorable acquisition geometries. Future perspectives on algorithm development and data analysis for prostate imaging are presented.

  4. Devices, systems, and methods for imaging

    DOE Patents [OSTI]

    Appleby, David (North Garden, VA); Fraser, Iain (Ruckersville, VA); Watson, Scott (Jemez Springs, NM)

    2008-04-15T23:59:59.000Z

    Certain exemplary embodiments comprise a system, which can comprise an imaging plate. The imaging plate can be exposable by an x-ray source. The imaging plate can be configured to be used in digital radiographic imaging. The imaging plate can comprise a phosphor-based image storage device configured to convert an image stored therein into light.

  5. Essays on prescription drug benefits in Medicare managed care

    E-Print Network [OSTI]

    Hall, Anne Elizabeth, 1971-

    2005-01-01T23:59:59.000Z

    In this thesis, I estimate a structural demand model for prescription drug benefits by Medicare beneficiaries using data from the Medicare HMO program. I then use the utility parameter estimates to explore other questions ...

  6. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01T23:59:59.000Z

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  8. antiretroviral drug fosamprenavir: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (0.08 m... Brouwers, Joachim 2006-10-25 3 Antiretroviral HIV treatment and care for injecting drug users: an evidence-based overview Physics Websites Summary: 1...

  9. antidiabetic drugs present: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    data to perform a number of econometric studies to assess the health and economic impacts of new drug development and use. I hypothesize that people may obtain several kinds...

  10. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01T23:59:59.000Z

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  11. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01T23:59:59.000Z

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  12. Page 1 of 5 Alcohol and Other Drugs

    E-Print Network [OSTI]

    Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

  13. Mechanism Based Anticancer Drugs that Degrade Sp Transcription Factors

    E-Print Network [OSTI]

    Chadalapaka, Gayathri

    2013-03-14T23:59:59.000Z

    Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. We demonstrated that curcumin inhibited 253JB-V and KU7 bladder cancer...

  14. Biosynthetic engineering for the assembly of better drugs

    E-Print Network [OSTI]

    Yadav, Vikramaditya Ganapati

    2013-01-01T23:59:59.000Z

    The declining prospects of innovator pharmaceutical companies have been attributed to their inability to discover leads that bind to novel protein domains. All of the 21,000-odd drug products that have ever been approved ...

  15. Cellular responses against DNA damaged by platinum anticancer drugs

    E-Print Network [OSTI]

    Jung, Yongwon, 1977-

    2005-01-01T23:59:59.000Z

    The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding ...

  16. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  17. Microcapsule drug delivery device for treatment of glioblastoma multiforme

    E-Print Network [OSTI]

    Scott, Alexander Wesley

    2010-01-01T23:59:59.000Z

    Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

  18. Engineered microtissue platforms for modeling human pathophysiology and drug metabolism

    E-Print Network [OSTI]

    Li, Cheri Yingjie

    2013-01-01T23:59:59.000Z

    Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

  19. antiangiogenic drug assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of 18 novel, anti-angiogenic 17- to 20-amino acid peptides Popel, Aleksander S. 10 Assessing malaria drug resistance in US military areas of operation using microarrays. Biology...

  20. Efficient MR image reconstruction for compressed MR imaging Junzhou Huang

    E-Print Network [OSTI]

    Huang, Junzhou

    to be very powerful for the MR image reconstruction. First, we decompose the original problem into L1 and TV.V. All rights reserved. 1. Introduction Magnetic Resonance (MR) imaging has been widely used in medical. Computation became the bottleneck that prevented this good model (1) from being used in practical MR image

  1. Efficient MR Image Reconstruction for Compressed MR Imaging

    E-Print Network [OSTI]

    Huang, Junzhou

    demonstrate the superior performance of the proposed algorithm for com- pressed MR image reconstruction. 1 [1][2] show that it is possi- ble to accurately reconstruct the Magnetic Resonance (MR) images from for real MR images. Computation became the bottleneck that prevented this good model (1) from being used

  2. Image Utility Assessment and a Relationship with Image Quality Assessment

    E-Print Network [OSTI]

    Hemami, Sheila S.

    Image Utility Assessment and a Relationship with Image Quality Assessment David M. Rouse , Romuald information to humans, and this paper investigates the utility assessment task, where human observers evaluate the usefulness of a natural image as a surrogate for a reference. Current QA algorithms implicitly assess utility

  3. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26T23:59:59.000Z

    directly for destruction by the body’s immune system. There are currently three antibody-drug conjugates and 11 ‘naked’ monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

  4. Comprehensive Study of Image Restoration Algorithms.

    E-Print Network [OSTI]

    Zong, Lize

    2015-01-01T23:59:59.000Z

    ??Abstract Comprehensive Study of Image Restoration Algorithms By Lize Zong Master of Science in Electrical Engineering Image restoration is an important part of digital image-processing.… (more)

  5. Unsupervised Image Ranking Eva Hrster

    E-Print Network [OSTI]

    Weinberger, Kilian

    these are the most interesting and relevant shots. For instance, if there are many images of the Golden Gate Bridge

  6. Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug

    E-Print Network [OSTI]

    Li, Meiyi, S.M. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    Nucleotide excision repair, a DNA repair mechanism, is the major repair pathway responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific ...

  7. 6, 19532001, 2006 Imaging gravity

    E-Print Network [OSTI]

    Boyer, Edmond

    ACPD 6, 1953­2001, 2006 Imaging gravity waves in lower stratospheric AMSU-A radiances S. D under a Creative Commons License. Atmospheric Chemistry and Physics Discussions Imaging gravity waves.eckermann@nrl.navy.mil) 1953 #12;ACPD 6, 1953­2001, 2006 Imaging gravity waves in lower stratospheric AMSU-A radiances S. D

  8. Fourier Analysis of Ghost Imaging

    E-Print Network [OSTI]

    Honglin Liu; Jing Cheng; Yanfeng Bai; Shensheng Han

    2006-09-28T23:59:59.000Z

    Fourier analysis of ghost imaging (FAGI) is proposed in this paper to analyze the properties of ghost imaging with thermal light sources. This new theory is compatible with the general correlation theory of intensity fluctuation and could explain some amazed phenomena. Furthermore we design a series of experiments to verify the new theory and investigate the inherent properties of ghost imaging.

  9. Automated Very Low Magnification Imaging

    E-Print Network [OSTI]

    of the entire available imaging area on the grid. The VLM image can then be used as a reference map of Illinois at Urbana- Champaign, Urbana, IL 61801. A typical TEM specimen grid provides approximately a 2x2 mm area that is available for imaging. In order to identify and locate suitable targets on the grid

  10. Multimode imaging device

    DOE Patents [OSTI]

    Mihailescu, Lucian; Vetter, Kai M

    2013-08-27T23:59:59.000Z

    Apparatus for detecting and locating a source of gamma rays of energies ranging from 10-20 keV to several MeV's includes plural gamma ray detectors arranged in a generally closed extended array so as to provide Compton scattering imaging and coded aperture imaging simultaneously. First detectors are arranged in a spaced manner about a surface defining the closed extended array which may be in the form a circle, a sphere, a square, a pentagon or higher order polygon. Some of the gamma rays are absorbed by the first detectors closest to the gamma source in Compton scattering, while the photons that go unabsorbed by passing through gaps disposed between adjacent first detectors are incident upon second detectors disposed on the side farthest from the gamma ray source, where the first spaced detectors form a coded aperture array for two or three dimensional gamma ray source detection.

  11. Imaging alpha particle detector

    DOE Patents [OSTI]

    Anderson, D.F.

    1980-10-29T23:59:59.000Z

    A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  12. Imaging alpha particle detector

    DOE Patents [OSTI]

    Anderson, David F. (Los Alamos, NM)

    1985-01-01T23:59:59.000Z

    A method and apparatus for detecting and imaging alpha particles sources is described. A conducting coated high voltage electrode (1) and a tungsten wire grid (2) constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source (3) to be quantitatively or qualitatively analyzed. A thin polyester film window (4) allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  13. Acoustic imaging microscope

    DOE Patents [OSTI]

    Deason, Vance A.; Telschow, Kenneth L.

    2006-10-17T23:59:59.000Z

    An imaging system includes: an object wavefront source and an optical microscope objective all positioned to direct an object wavefront onto an area of a vibrating subject surface encompassed by a field of view of the microscope objective, and to direct a modulated object wavefront reflected from the encompassed surface area through a photorefractive material; and a reference wavefront source and at least one phase modulator all positioned to direct a reference wavefront through the phase modulator and to direct a modulated reference wavefront from the phase modulator through the photorefractive material to interfere with the modulated object wavefront. The photorefractive material has a composition and a position such that interference of the modulated object wavefront and modulated reference wavefront occurs within the photorefractive material, providing a full-field, real-time image signal of the encompassed surface area.

  14. Imaging the Antikythera Mechanism

    SciTech Connect (OSTI)

    Malzbender, Tom (Hewlett Packard Laboratories) [Hewlett Packard Laboratories

    2011-01-12T23:59:59.000Z

    In 1900, a party of sponge divers chanced on the wreck of a Roman merchant vessel between Crete and mainland Greece. It was found to contain numerous ancient Greek treasures, among them a mysterious lump of clay that split open to reveal 'mathematical gears' as it dried out. This object is now known as the Antikythera Mechanism, one of the most enlightening artifacts in terms of revealing the advanced nature of ancient Greek science and technology. In 2005 we travelled to the National Archeological Museum in Athens to apply our Reflectance Imaging methods to the mechanism in the hopes of revealing ancient writing on the device. We were successful, and along with the results of Microfocus CT imaging, we are able to decipher 3000 characters compared with the original 800 known. This lead to an understanding that the device was a mechanical, astronomical computer from 150 B.C.E. capable of predicting solar and lunar eclipses along with other celestial events. This talk will overview both the imaging methods as well as what they reveal about the Antikythera Mechanism.

  15. Fiducial marker for correlating images

    DOE Patents [OSTI]

    Miller, Lisa Marie (Rocky Point, NY); Smith, Randy J. (Wading River, NY); Warren, John B. (Port Jefferson, NY); Elliott, Donald (Hampton Bays, NY)

    2011-06-21T23:59:59.000Z

    The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains.

  16. Bistatic SAR: Imagery & Image Products.

    SciTech Connect (OSTI)

    Yocky, David A.; Wahl, Daniel E.; Jakowatz, Charles V,

    2014-10-01T23:59:59.000Z

    While typical SAR imaging employs a co-located (monostatic) RADAR transmitter and receiver, bistatic SAR imaging separates the transmitter and receiver locations. The transmitter and receiver geometry determines if the scattered signal is back scatter, forward scatter, or side scatter. The monostatic SAR image is backscatter. Therefore, depending on the transmitter/receiver collection geometry, the captured imagery may be quite different that that sensed at the monostatic SAR. This document presents imagery and image products formed from captured signals during the validation stage of the bistatic SAR research. Image quality and image characteristics are discussed first. Then image products such as two-color multi-view (2CMV) and coherent change detection (CCD) are presented.

  17. Speckle-free laser imaging

    E-Print Network [OSTI]

    Redding, Brandon; Cao, Hui

    2011-01-01T23:59:59.000Z

    Many imaging applications require increasingly bright illumination sources, motivating the replacement of conventional thermal light sources with light emitting diodes (LEDs), superluminescent diodes (SLDs) and lasers. Despite their brightness, lasers and SLDs are poorly suited for full-field imaging applications because their high spatial coherence leads to coherent artifacts known as speckle that corrupt image formation. We recently demonstrated that random lasers can be engineered to provide low spatial coherence. Here, we exploit the low spatial coherence of specifically-designed random lasers to perform speckle-free full-field imaging in the setting of significant optical scattering. We quantitatively demonstrate that images generated with random laser illumination exhibit higher resolution than images generated with spatially coherent illumination. By providing intense laser illumination without the drawback of coherent artifacts, random lasers are well suited for a host of full-field imaging applicatio...

  18. Biomedical Imaging & Informatics | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biomedical Imaging & Informatics - European Research and Training Initiative Biomedical Imaging & Informatics - European Research and Training Initiative Dr. Marion I. Menzel...

  19. Drug-Free Workplace Program UT-B Contracts Page 1 of 1

    E-Print Network [OSTI]

    Pennycook, Steve

    Drug-Free Workplace Program UT-B Contracts Sep 2012 Page 1 of 1 drug-free-workplace-ext-sep12 DRUG-FREE, the Seller and its subcontractors working on the project site must maintain a drug-free workplace program. (B) If the Seller is an out-of-state entity, the Company may upon request allow a drug-free workplace

  20. Photogrammetry & Machine Vision 1. Image sensors

    E-Print Network [OSTI]

    Giger, Christine

    Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image. Remondino, N. D'Apuzzo Photogrammetry and Machine Vision ­ 1. Measurement in images (b) Camera calibration of Photogrammetry and Machine Vision Fully understand: 1. Image based 3D and 4D measurement 2. Image based 3D

  1. ON THE CONTINUITY OF IMAGES BY TRANSMISSION IMAGING Abstract. Transmission imaging is an important imaging technique which is widely used in

    E-Print Network [OSTI]

    Soatto, Stefano

    ON THE CONTINUITY OF IMAGES BY TRANSMISSION IMAGING CHUNLIN WU Abstract. Transmission imaging imaging principle is quite different from that of reflection imaging used in our everyday life. As well scholars studied the application of TV regularization to processing images generated by transmission

  2. The use of carbon stable isotope ratios in drugs characterization

    SciTech Connect (OSTI)

    Magdas, D. A., E-mail: gabriela.cristea@itim-cj.ro; Cristea, G., E-mail: gabriela.cristea@itim-cj.ro; Bot, A., E-mail: gabriela.cristea@itim-cj.ro; Mirel, V., E-mail: gabriela.cristea@itim-cj.ro [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Str., 400293 Cluj-Napoca (Romania)

    2013-11-13T23:59:59.000Z

    Isotopic Ratio Mass Spectrometry (IRMS) is an effective toll to be used for drug product authentication. The isotopic composition could be used to assist in the differentiation between batches of drugs and assist in the identification of counterfeit materials on the market. Only two factors affect the isotopic ratios in pharmaceutical components: the isotopic composition of the raw materials and the synthetic processes performed upon them. Counterfeiting of pharmaceutical drugs threatens consumer confidence in drug products companies' economical well-being. In this preliminary study, the analyzed samples consist in two types of commercially available analgesics, which were purchases from Romanian pharmacies. Differences in ?{sup 13}C between batches from ?29.7 to ?31.6% were observed, demonstrating that this method can be used to differentiate among individual drug batches and subsequently identify counterfeits on the market. On the other hand, carbon isotopic ratios differences among producers were recorded, the variations being between ?31.3 to ?34.9% for the same type of analgesic, but from different manufactures.

  3. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  4. Device for wavelength-selective imaging

    DOE Patents [OSTI]

    Frangioni, John V. (Wayland, MA)

    2010-09-14T23:59:59.000Z

    An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.

  5. Associated particle imaging (API)

    SciTech Connect (OSTI)

    NONE

    1998-05-01T23:59:59.000Z

    Associated Particle Imaging (API) is an active neutron probe technique that provides a 3-D image with elemental composition of the material under interrogation, and so occupies a unique niche in the interrogation of unknown objects. The highly penetrating nature of neutrons enables API to provide detailed information about targets of interest that are hidden from view. Due to the isotropic nature of the induced reactions, radiation detectors can be set on the same side of the object as the neutron source, so that the object can be interrogated from a single side. At the heat of the system is a small generator that produces a continuous, monoenergetic flux of neutrons. By measuring the trajectory of coincident alpha particles that are produced as part of the process, the trajectory of the neutron can be inferred. Interactions between a neutron and the material in its path often produce a gamma ray whose energy is characteristic of that material. When the gamma ray is detected, its energy is measured and combined with the trajectory information to produce a 3-D image of the composition of the object being interrogated. During the course of API development, a number of improvements have been made. A new, more rugged sealed Tube Neutron Generator (STNG) has been designed and fabricated that is less susceptible to radiation damage and better able to withstand the rigors of fielding than earlier designs. A specialized high-voltage power supply for the STNG has also been designed and built. A complete package of software has been written for the tasks of system calibration, diagnostics and data acquisition and analysis. A portable system has been built and field tested, proving that API can be taken out of the lab and into real-world situations, and that its performance in the field is equal to that in the lab.

  6. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, H.O.; Martin, D.C.; Lampton, M.L.

    1983-07-26T23:59:59.000Z

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally. 15 figs.

  7. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, Hal O. (Berkeley, CA); Martin, Donn C. (Berkeley, CA); Lampton, Michael L. (Berkeley, CA)

    1983-01-01T23:59:59.000Z

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

  8. Superconductive imaging surface magnetometer

    DOE Patents [OSTI]

    Overton, Jr., William C. (Los Alamos, NM); van Hulsteyn, David B. (Santa Fe, NM); Flynn, Edward R. (Los Alamos, NM)

    1991-01-01T23:59:59.000Z

    An improved pick-up coil system for use with Superconducting Quantum Interference Device gradiometers and magnetometers involving the use of superconducting plates near conventional pick-up coil arrangements to provide imaging of nearby dipole sources and to deflect environmental magnetic noise away from the pick-up coils. This allows the practice of gradiometry and magnetometry in magnetically unshielded environments. One embodiment uses a hemispherically shaped superconducting plate with interior pick-up coils, allowing brain wave measurements to be made on human patients. another embodiment using flat superconducting plates could be used in non-destructive evaluation of materials.

  9. Imaging XPS | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLCBasicsScienceRadiation LightsourceImaging XPS

  10. Fourier plane image amplifier

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Hermann, Mark R. (San Ramon, CA); Dane, C. Brent (Livermore, CA); Tiszauer, Detlev H. (Tracy, CA)

    1995-01-01T23:59:59.000Z

    A solid state laser is frequency tripled to 0.3 .mu.m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only .about.1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power.

  11. A matter of collection and detection for intraoperative and noninvasive near-infrared fluorescence molecular imaging: To see or not to see?

    SciTech Connect (OSTI)

    Zhu, Banghe; Rasmussen, John C.; Sevick-Muraca, Eva M., E-mail: Eva.Sevick@uth.tmc.edu [Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas 77030 (United States)

    2014-02-15T23:59:59.000Z

    Purpose: Although fluorescence molecular imaging is rapidly evolving as a new combinational drug/device technology platform for molecularly guided surgery and noninvasive imaging, there remains no performance standards for efficient translation of “first-in-humans” fluorescent imaging agents using these devices. Methods: The authors employed a stable, solid phantom designed to exaggerate the confounding effects of tissue light scattering and to mimic low concentrations (nM–pM) of near-infrared fluorescent dyes expected clinically for molecular imaging in order to evaluate and compare the commonly used charge coupled device (CCD) camera systems employed in preclinical studies and in human investigational studies. Results: The results show that intensified CCD systems offer greater contrast with larger signal-to-noise ratios in comparison to their unintensified CCD systems operated at clinically reasonable, subsecond acquisition times. Conclusions: Camera imaging performance could impact the success of future “first-in-humans” near-infrared fluorescence imaging agent studies.

  12. Application of Parallel Imaging to Murine Magnetic Resonance Imaging

    E-Print Network [OSTI]

    Chang, Chieh-Wei 1980-

    2012-09-21T23:59:59.000Z

    . This dissertation describes foundational level work to enable parallel imaging of mice on a 4.7 Tesla/40 cm bore research scanner. Reducing the size of the hardware setup associated with typical parallel imaging was an integral part of achieving the work, as animal...

  13. Processing Visual Images

    SciTech Connect (OSTI)

    Litke, Alan (UC Santa Cruz) [UC Santa Cruz

    2006-03-27T23:59:59.000Z

    The back of the eye is lined by an extraordinary biological pixel detector, the retina. This neural network is able to extract vital information about the external visual world, and transmit this information in a timely manner to the brain. In this talk, Professor Litke will describe a system that has been implemented to study how the retina processes and encodes dynamic visual images. Based on techniques and expertise acquired in the development of silicon microstrip detectors for high energy physics experiments, this system can simultaneously record the extracellular electrical activity of hundreds of retinal output neurons. After presenting first results obtained with this system, Professor Litke will describe additional applications of this incredible technology.

  14. Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG &

    E-Print Network [OSTI]

    Puglisi, Joseph

    Kelly Scientific Resources Kelly Scientific Resources yy BIOTECHNOLOGY DRUG & PHARMACEUTICAL · What Kelly Scientific Resources or staffing agencies are and how they work?they work? · How to work Role: ­ Northern California Recruiting and Business efforts for Kelly Scientific Resources ­ Promote

  15. Optimization and Simulation in Drug Development -Review and Analysis

    E-Print Network [OSTI]

    in the context of the pharmaceutical industry. 4 #12; 1 Introduction The presen-Eriksen and Jens Clausen Keywords: Pharmaceutical R&D, Drug Discovery and Development, Modelling and sim- ulation, Clinical Trial Simulation Portfolio optimization 1 #12; Contents 1 Introduction 5 2 Pharmaceutical products

  16. Rigor Through the Lens of Drug Discovery and Development

    E-Print Network [OSTI]

    flavors of incentives: economic, social, and moral. · Academic and Industrial cultures/ incentivesRigor Through the Lens of Drug Discovery and Development · The game · Culture and incentives · Our and development? · Resources: Money, time, and access to multiple non-academic skill sets · Incentives/ Culture

  17. Protein Dynamics in Drug Combinations: a Linear Superposition

    E-Print Network [OSTI]

    on cells and organisms. Little is known about how drugs affect protein dynamics that deter- mine or activity) of one of the cells proteins (Figure 1). The goal is to guide the cell from a ``sick state'' to a ``healthy state'' in a rational manner (or, in the case of cancer, from a living cancer cell to a dead

  18. Molecular Fragment Mining for Drug Discovery Christian Borgelt1

    E-Print Network [OSTI]

    Berthold, Michael R.

    Molecular Fragment Mining for Drug Discovery Christian Borgelt1 , Michael R. Berthold2 , and David will be active or inactive, so that future chemical tests can be focused on the most promis- ing candidates that discriminate between active and inactive molecules. In this paper we review this approach as well as two

  19. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    of a model compound, luciferin, from poly(lactic acid) (PLA) particles (approximately 250­350 nm in size nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA with supercritical carbon dioxide (sc-CO2). PLA can also serve as a representative material for our process which can

  20. Nearly all current drugs for osteoporosis act by inhibiting the

    E-Print Network [OSTI]

    for the development of osteoporosis in post-menopausal women. Control mice developed an osteopaenia, whereas mice fedNearly all current drugs for osteoporosis act by inhibiting the resorption of bone, and novel or reverse this disease in rodents. Osteoporosis is characterized by decreased bone density and strength

  1. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  2. (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs

    E-Print Network [OSTI]

    Weber, David J.

    (c) Meade & Roach, LLP 1 Medicare's Impact on Cardiology Drugs and Devices During Clinical Research Ryan Meade, JD Meade & Roach, LLP July 15, 2008 Baltimore, Maryland University of Maryland School of Medicine #12;(c) Meade & Roach, LLP 2 Overview Theme: Understanding Medicare reimbursement helps

  3. Imaging synthetic aperture radar

    DOE Patents [OSTI]

    Burns, Bryan L. (Tijeras, NM); Cordaro, J. Thomas (Albuquerque, NM)

    1997-01-01T23:59:59.000Z

    A linear-FM SAR imaging radar method and apparatus to produce a real-time image by first arranging the returned signals into a plurality of subaperture arrays, the columns of each subaperture array having samples of dechirped baseband pulses, and further including a processing of each subaperture array to obtain coarse-resolution in azimuth, then fine-resolution in range, and lastly, to combine the processed subapertures to obtain the final fine-resolution in azimuth. Greater efficiency is achieved because both the transmitted signal and a local oscillator signal mixed with the returned signal can be varied on a pulse-to-pulse basis as a function of radar motion. Moreover, a novel circuit can adjust the sampling location and the A/D sample rate of the combined dechirped baseband signal which greatly reduces processing time and hardware. The processing steps include implementing a window function, stabilizing either a central reference point and/or all other points of a subaperture with respect to doppler frequency and/or range as a function of radar motion, sorting and compressing the signals using a standard fourier transforms. The stabilization of each processing part is accomplished with vector multiplication using waveforms generated as a function of radar motion wherein these waveforms may be synthesized in integrated circuits. Stabilization of range migration as a function of doppler frequency by simple vector multiplication is a particularly useful feature of the invention; as is stabilization of azimuth migration by correcting for spatially varying phase errors prior to the application of an autofocus process.

  4. Image Mining: Detecting Deforestation Patterns

    E-Print Network [OSTI]

    Camara, Gilberto

    54 Chapter IV Image Mining: Detecting Deforestation Patterns Through Satellites Marcelino Pereira to analyze satellite images and extract knowledge from this kind of data. The Amazonia deforestation problem of change on deforested areas of Amazonia. The purpose of the authors is to present relevant technologies

  5. Spatial Sampling for Image Segmentation

    E-Print Network [OSTI]

    Rivera, Mariano

    AND ALONSO RAMIREZ­MANZANARES3 1 Centro de Investigacion en Matematicas A.C, Guanajuato GTO 36000, Mexico 2 Matematicas, Guanajuato GTO 36000, Mexico Email: mrivera@cimat.mx We present a novel framework for image­ processing in order to obtain a desired solution. On the other hand, the image segmentation is commonly

  6. Image texture analysis of elastograms

    E-Print Network [OSTI]

    Hussain, Fasahat

    1999-01-01T23:59:59.000Z

    generated elastograms to obtain effective texture features. Four image analysis techniques, co-occurrence statistics, wavelet decomposition, fractal analysis and granulomeay are used to extract a number of features from each image. The inclusions...-RESOLUTION FRACTAL ANALYSIS . . . . . . E. GRANULOMETRIC FEATURES . . F. DATA NORMALIZATION . G. SEPARABILITY MEASURE 13 13 . . . . . 14 . . . . . 20 . . . . . 29 33 36 36 IV TEXTURE ANALYSIS OF SIMULATED ELASTOGRAMS. . . . . . . . . . . 38 A. SIMULATION...

  7. Nested Images Qiang Tong#1

    E-Print Network [OSTI]

    Martin, Ralph R.

    Nested Images Qiang Tong#1 , Song-Hai Zhang#2 , Ralph R. Martin*3 , Paul L. Rosin*4 # Tsinghua.Rosin@cs.cardiff.ac.uk Abstract--A nested image is a form of artistic expression in which one or more secondary figures detects the enclosed outer contour of the figure to be nested, and then finds a place in the outer figure

  8. Geosciences 466/566 Digital Image Processing

    E-Print Network [OSTI]

    Wright, Dawn Jeannine

    Geosciences 466/566 Digital Image Processing Winter 2007 Instructor Dr. Anne Nolin Wilkinson 120 This course focuses on the digital image processing of satellite image data. Topics include: data types, image://my.oregonstate.edu Textbook Jensen, J. R., Digital Image Processing: A Remote Sensing Perspective, 3rd Edition, Prentice Hall

  9. Simultaneous acquisition of differing image types

    DOE Patents [OSTI]

    Demos, Stavros G

    2012-10-09T23:59:59.000Z

    A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. A method in one embodiment includes receiving an image from an image forming device; decomposing the image formed by the image forming device into multiple component parts based on type of imaging; receiving the component parts of the image; and outputting image information based on the component parts of the image. Additional systems and methods are presented.

  10. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  11. Assessing the impact of tumor evolution on oncology drug development and commercialization

    E-Print Network [OSTI]

    Sterk, Joseph P. (Sterk, Joseph Phillip)

    2011-01-01T23:59:59.000Z

    This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

  12. E-Print Network 3.0 - anticancer drugs infusion Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drugs infusion Search Powered by Explorit Topic List Advanced Search Sample search results for: anticancer drugs infusion Page: << < 1 2 3 4 5 > >> 1 Friday, April 29, 2011 UNM...

  13. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  14. Medical data mining : improving information accessibility using online patient drug reviews

    E-Print Network [OSTI]

    Li, Yueyang Alice

    2011-01-01T23:59:59.000Z

    We address the problem of information accessibility for patients concerned about, pharmaceutical drug side effects and experiences. We create a new corpus of online patient-provided drug reviews and present our initial ...

  15. Changes in the characteristics of approved New Drug Applications for antihypertensives

    E-Print Network [OSTI]

    MacNeil, John Simon Howe

    2007-01-01T23:59:59.000Z

    In this thesis, the control of hypertension provides the backdrop for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug ...

  16. Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON

    E-Print Network [OSTI]

    Fernandez, Eduardo

    Analysis: Why Drug Porn Isn't Exciting Anymore By TED HESSON Dec. 20, 2012-- The Imagery of pornography: like war porn, torture porn or the standard naked-people porn, drug porn offers up a taste

  17. E-Print Network 3.0 - anticancer drug carriers Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    results for: anticancer drug carriers Page: << < 1 2 3 4 5 > >> 1 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

  18. Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System

    E-Print Network [OSTI]

    Yu, Shi

    A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ...

  19. The dual-piston jet injector and the viability of drug delivery

    E-Print Network [OSTI]

    Cunningham, Daniel (Daniel P.)

    2007-01-01T23:59:59.000Z

    Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

  20. E-Print Network 3.0 - activation inhibits drug-resistant Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    as a function of: (i) the transmissibility (i.e., fitness) of the drug-resistant... that transmission of drug-resistant strains in Botswana could increase to ,15% by 2009 if...

  1. E-Print Network 3.0 - anti-cancer drug design Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Powered by Explorit Topic List Advanced Search Sample search results for: anti-cancer drug design Page: << < 1 2 3 4 5 > >> 1 Biology-based Drug Design Summary: - New...

  2. FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data Taken at ALS FDA Approves Drug for Type 2 Diabetes Invented with Aid of Protein Structure Data...

  3. Computational analysis of biochemical networks for drug target identification and therapeutic intervention design

    E-Print Network [OSTI]

    Paudel, Nirmala

    2014-01-01T23:59:59.000Z

    Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

  4. Improving cancer treatment with cyclotron produced radionuclides. [Multiple Drug Resistance (MDR)

    SciTech Connect (OSTI)

    Larson, S.M.; Finn, R.D.

    1990-10-15T23:59:59.000Z

    The overall objective of this work was to promote nuclear medicine applications in oncology. This is being done by improving the scientific basis of diagnosis, treatment and treatment follow-up with cyclotron-produced tracers. For diagnostic use, positron-emitting isotopes such as Ga-66 and I-124 are being used. Initial studies on the characterization of He-4 particle energies required for Ga-66 production have been completed. Parameters for I-124 radiolabelling of monoclonal antibodies have been determined; the labelled antibodies have been used in animal studies using positron emission tomography (PET) to quantify antibody concentration within tumors in vivo. Imaging physics studies have demonstrated that I-124 can be quantitatively imaged by PET, even in the presence of 100-told greater concentrations of I-131. Measurement of concentrations of label in vivo has been accomplished in nuclei mice bearing neuroblastoma tumors and nude rats bearing human ovarian cancer cells. These studies have major implications for both the quantification of dosimetry and quantification kinetic assessment of anti-tumor antibody localization in vivo. For treatment of tumors, F-18 has been incorporated in 2-fluoro-2-deoxy glucose and 5-fluoro uridine, and O-15 labelled water has been produced. Reagents incorporating C-11 and N-13 are under development. In a related area, C-14 labelled colchicine is being studied as a means of assaying cells for multiple drug resistance (MDR). Cells expressing MDR are shown to retain significantly less C-14 colchiene. This suggest that colchiene retention may be of useful probe in modelling and studying MDR development in human tumors. The precursor required for producing C-11 colchicine has also been synthesized. 11 refs. (MHB)

  5. Digital holographic imaging of aquatic species

    E-Print Network [OSTI]

    Domínguez-Caballero, José Antonio

    2006-01-01T23:59:59.000Z

    The aim of this thesis is to design, develop and implement a digital holographic imaging (DHI) system, capable of capturing three-dimensional (3D) images of aquatic species. The images produced by this system are used in ...

  6. Semantic image representation for visual recognition

    E-Print Network [OSTI]

    Rasiwasia, Nikhil

    2011-01-01T23:59:59.000Z

    Flickr Images (F18) . . . . . . . . . . . . . . . A.1.5A.1.3. Flickr Images (F18) consists of 1, 800 images fromset. A detailed description of F18 is provided in Appendix.

  7. ESPC Success Story- Food and Drug Administration (FDA) White Oak Campus

    Broader source: Energy.gov [DOE]

    FEMP ESPC Success Story on water conservation and green energy at the Food and Drug Administration (FDA) White Oak Campus.

  8. E-Print Network 3.0 - antimalarial drug resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease pathophysiology, drug resistance... and antimalarial resistance, and optimising treatments for pregnant women melioidosis - conducting clinical... treatments,...

  9. E-Print Network 3.0 - antiretroviral drug costs Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment... formulations and simplified ARV regimens optimized...

  10. Reaction product imaging

    SciTech Connect (OSTI)

    Chandler, D.W. [Sandia National Laboratories, Livermore, CA (United States)

    1993-12-01T23:59:59.000Z

    Over the past few years the author has investigated the photochemistry of small molecules using the photofragment imaging technique. Bond energies, spectroscopy of radicals, dissociation dynamics and branching ratios are examples of information obtained by this technique. Along with extending the technique to the study of bimolecular reactions, efforts to make the technique as quantitative as possible have been the focus of the research effort. To this end, the author has measured the bond energy of the C-H bond in acetylene, branching ratios in the dissociation of HI, the energetics of CH{sub 3}Br, CD{sub 3}Br, C{sub 2}H{sub 5}Br and C{sub 2}H{sub 5}OBr dissociation, and the alignment of the CD{sub 3} fragment from CD{sub 3}I photolysis. In an effort to extend the technique to bimolecular reactions the author has studied the reaction of H with HI and the isotopic exchange reaction between H and D{sub 2}.

  11. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W. (East Moriches, NY); Brill, A. Bertrand (Shoreham, NY); Bizais, Yves J. C. (Upton, NY); Rowe, R. Wanda (Upton, NY); Zubal, I. George (Upton, NY)

    1986-01-01T23:59:59.000Z

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  12. Image indexing using color correlograms

    DOE Patents [OSTI]

    Huang, Jing (Ossining, NY); Kumar, Shanmugasundaram Ravi (San Jose, CA); Mitra, Mandar (Calcutta, IN); Zhu, Wei-Jing (Ossining, NY)

    2001-01-01T23:59:59.000Z

    A color correlogram is a three-dimensional table indexed by color and distance between pixels which expresses how the spatial correlation of color changes with distance in a stored image. The color correlogram may be used to distinguish an image from other images in a database. To create a color correlogram, the colors in the image are quantized into m color values, c.sub.i . . . c.sub.m. Also, the distance values k.epsilon.[d] to be used in the correlogram are determined where [d] is the set of distances between pixels in the image, and where dmax is the maximum distance measurement between pixels in the image. Each entry (i, j, k) in the table is the probability of finding a pixel of color c.sub.i at a selected distance k from a pixel of color c.sub.i. A color autocorrelogram, which is a restricted version of the color correlogram that considers color pairs of the form (i,i) only, may also be used to identify an image.

  13. CABM Symposium Applications of NMR to structure-based drug design in structural

    E-Print Network [OSTI]

    Powers, Robert

    CABM Symposium Applications of NMR to structure-based drug design in structural genomics Robert, structure-based drug design, structural genomics Abstract Structural genomics is poised to have a tremendous design in the era of structural genomics. Introduction Structure-based drug design has established itself

  14. ORNL microscopy directly images problematic lithium dendrites...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    865.574.7308 ORNL microscopy directly images problematic lithium dendrites in batteries ORNL electron microscopy captured the first real-time nanoscale images of the nucleation and...

  15. Correlated Biofilm Imaging, Transport and Metabolism Measurements...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biofilm Imaging, Transport and Metabolism Measurements via Combined Nuclear Magnetic Resonance and Confocal Correlated Biofilm Imaging, Transport and Metabolism Measurements via...

  16. Use of Preventative and Therapeutic Drugs in Show Market Animals

    E-Print Network [OSTI]

    Faries Jr., Floron C.

    2001-03-12T23:59:59.000Z

    Various preventive and therapeutic medicines may be used for disease management in show mar- ket livestock and poultry. These include vaccines and bacterins, antibiotics and antibacterials, para- siticides and corticosteroids. Exhibitors of show ani.... These instructions are to be followed precisely. L-2335 2-01 Use of Preventive and Therapeutic Drugs in Show Market Animals F.C. Faries, Jr. Associate Professor and Extension Program Leader for Veterinary Medicine The Texas A&M University System Testing The Food...

  17. The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout

    SciTech Connect (OSTI)

    Prindiville, John S., E-mail: jprin041@uottawa.ca; Mennigen, Jan A.; Zamora, Jake M.; Moon, Thomas W.; Weber, Jean-Michel

    2011-03-15T23:59:59.000Z

    Gemfibrozil (GEM) is a fibrate drug consistently found in effluents from sewage treatment plants. This study characterizes the pharmacological effects of GEM on the plasma lipoproteins of rainbow trout (Oncorhynchus mykiss). Our goals were to quantify the impact of the drug on: 1) lipid constituents of lipoproteins (phospholipids (PL), triacylglycerol (TAG), and cholesterol), 2) lipoprotein classes (high, low and very low density lipoproteins), and 3) fatty acid composition of lipoproteins. Potential mechanisms of GEM action were investigated by measuring lipoprotein lipase activity (LPL) and the hepatic gene expression of LPL and of the peroxisome proliferator-activated receptor (PPAR) {alpha}, {beta}, and {gamma} isoforms. GEM treatment resulted in decreased plasma lipoprotein levels (- 29%) and a reduced size of all lipoprotein classes (lower PL:TAG ratios). However, the increase in HDL-cholesterol elicited by GEM in humans failed to be observed in trout. Therefore, HDL-cholesterol cannot be used to assess the impact of the drug on fish. GEM also modified lipoprotein composition by reducing the abundance of long-chain n-3 fatty acids, thereby potentially reducing the nutritional quality of exposed fish. The relative gene expression of LPL was increased, but the activity of the enzyme was not, and we found no evidence for the activation of PPAR pathways. The depressing effects of GEM on fish lipoproteins demonstrated here may be a concern in view of the widespread presence of fibrates in aquatic environments. Work is needed to test whether exposure to environmental concentrations of these drugs jeopardizes the capacity of fish for reproduction, temperature acclimation or migratory behaviors.

  18. Drug repositioning and indication discovery using description logics

    E-Print Network [OSTI]

    Croset, Samuel

    2014-10-07T23:59:59.000Z

    behind the repurposing. Understanding the logic backing the 21 findings is paramount in order to build successful predictive methods later on. 1.2.1 Sildenafil: repositioning from clinical side-effects The National Health Service (NHS) defines angina as a... breast cancer preventive properties. This drug is an example of smart and continuous development, expanding from one indication to another. The fundamental reasons behind the repositioning are grounded on early-stage experimental evidence and not due to a...

  19. Feeling molecular forces: tactile feedback to enhance drug design

    E-Print Network [OSTI]

    Williams, Jocylin Amber

    2013-02-22T23:59:59.000Z

    Programs 8 Academic Scholarships Texas A8 M University In partial fulfillment of the requirements of the UNIVERSITY UNDERGRADUATE RESEARCH FELLOWS Approved as to style and content by: Edgar F. Meyer' (Fellows-Co-Advisor) Edward A. Funkhouser... (Executive Director) Stanley . Swanson (Fellows o-Advisor) April 2000 Group: Computer Science ABSTRACT FEELING MOLECULAR FORCES: TACTII E FEEDBACK TO ENHANCE DRUG DESIGN. (April 2000) Jocylin Amber Williams Department of Biochemistry and Biophysics...

  20. VAX-based ''IMAGE'' backup

    SciTech Connect (OSTI)

    Harris, D.D.

    1985-10-01T23:59:59.000Z

    Increasing usage of the Applicon IMAGE systems at Bendix Kansas City Division (BKC) conflicts with the need to do daily backup of changed AGS files. This paper describes a VAX-based method for automated, unattended, off-shift backup.

  1. Imaging atoms in 3-D

    SciTech Connect (OSTI)

    Ercius, Peter

    2013-10-31T23:59:59.000Z

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  2. Imaging atoms in 3-D

    ScienceCinema (OSTI)

    Ercius, Peter

    2014-06-27T23:59:59.000Z

    Berkeley Lab's Peter Ercius discusses "Imaging atoms in 3-D" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas

  3. Identifying structural damage from images

    E-Print Network [OSTI]

    Chen, ZhiQiang

    2009-01-01T23:59:59.000Z

    Pattern Recognition, 26 PDC. Paci?c disater center, 2008.which were acquired from the Paci?c Disaster Center (PDC) (PDC, 2008). These images cover Banda Aceh and its

  4. Methods for functional brain imaging

    E-Print Network [OSTI]

    Witzel, Thomas, Ph. D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    Magnetic resonance imaging (MRI) has demonstrated the potential for non-invasive mapping of structure and function (fMRI) in the human brain. In this thesis, we propose a series of methodological developments towards ...

  5. Imaging Liquids Using Microfluidic Cells

    SciTech Connect (OSTI)

    Yu, Xiao-Ying; Liu, Bingwen; Yang, Li

    2013-05-10T23:59:59.000Z

    Chemistry occurring in the liquid and liquid surface is important in many applications. Chemical imaging of liquids using vacuum based analytical techniques is challenging due to the difficulty in working with liquids with high volatility. Recent development in microfluidics enabled and increased our capabilities to study liquid in situ using surface sensitive techniques such as electron microscopy and spectroscopy. Due to its small size, low cost, and flexibility in design, liquid cells based on microfluidics have been increasingly used in studying and imaging complex phenomena involving liquids. This paper presents a review of microfluidic cells that were developed to adapt to electron microscopes and various spectrometers for in situ chemical analysis and imaging of liquids. The following topics will be covered including cell designs, fabrication techniques, unique technical features for vacuum compatible cells, and imaging with electron microscopy and spectroscopy. Challenges are summarized and recommendations for future development priority are proposed.

  6. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, M.A.; Tsang, B.W.

    1994-06-28T23:59:59.000Z

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography. 6 figures.

  7. Radiopharmaceuticals for imaging the heart

    DOE Patents [OSTI]

    Green, Mark A. (West Lafayette, IN); Tsang, Brenda W. (Lafayette, IN)

    1994-01-01T23:59:59.000Z

    Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.

  8. Soviet image pattern recognition research

    SciTech Connect (OSTI)

    McKenney, B.L.; McGrain, M. (eds.) (Science Applications International Corp., McLean, VA (USA). Foreign Applied Sciences Assessment Center); Klinger, A. (California Univ., Los Angeles, CA (USA). Dept. of Computer Science); Aggarwal, J.K. (Texas Univ., Austin, TX (USA)); George, N.J. (Rochester Univ., NY (USA). Inst. of Optics); Haralick, R.M. (Washington Univ., Seattle, WA (USA). Dept. of Electric

    1989-12-01T23:59:59.000Z

    This report is an assessment of the published Soviet image pattern recognition (IPR) research and was written by a panel of six US academic experts in that research field. Image pattern recognition is a set of technological research topics involving automatic or interactive computer processing of pictorial information, utilizing optical, electronic, and computer technologies. This report focuses on IPR system configuration (optical, hybrid, digital), and current research. The topical chapter headings are Image Processing Hardware and Software Preprocessing, Statistical Pattern Recognition, Computer Vision, and Optical Techniques and Systems. Soviet research in all areas of IPR is strong in theory, but limited by poor availability of equipment for generating and handling digital images, and digital computer hardware and software. Nevertheless, some Soviet IPR achievements compare favorably with those of the West. There is strong Soviet research in statistical pattern recognition, where fundamental relationships related to the factors determining error rates in classification of images are being developed. There has been good Soviet work in enhancement and restoration of images (visible and radar) of the surface of Venus. There is a strong Soviet development program in optics and optical processing related to IPR. Nevertheless, the state of Soviet research in computer vision is ten to fifteen years behind the West, because of the lack of adequate hardware and software. The Soviet scientists in the area appear competent and knowledgeable of Western work, so that any improvement in their research output would be derived from access to more capable equipment. 402 refs., 4 figs., 4 tabs.

  9. High speed imager test station

    DOE Patents [OSTI]

    Yates, G.J.; Albright, K.L.; Turko, B.T.

    1995-11-14T23:59:59.000Z

    A test station enables the performance of a solid state imager (herein called a focal plane array or FPA) to be determined at high image frame rates. A programmable waveform generator is adapted to generate clock pulses at determinable rates for clock light-induced charges from a FPA. The FPA is mounted on an imager header board for placing the imager in operable proximity to level shifters for receiving the clock pulses and outputting pulses effective to clock charge from the pixels forming the FPA. Each of the clock level shifters is driven by leading and trailing edge portions of the clock pulses to reduce power dissipation in the FPA. Analog circuits receive output charge pulses clocked from the FPA pixels. The analog circuits condition the charge pulses to cancel noise in the pulses and to determine and hold a peak value of the charge for digitizing. A high speed digitizer receives the peak signal value and outputs a digital representation of each one of the charge pulses. A video system then displays an image associated with the digital representation of the output charge pulses clocked from the FPA. In one embodiment, the FPA image is formatted to a standard video format for display on conventional video equipment. 12 figs.

  10. Image description. Cover Image End of image description. NATIONAL CENTER FOR EDUCATION STATISTICS

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    a context for examining the data they submitted to IPEDS. Our goal is to produce a report that is useful University 2 #12;Image description. Bar chart with 10 groups with 2 items per group.Y scale titled Percent

  11. Image Based Gisting in CLIR Mark Sanderson

    E-Print Network [OSTI]

    Sanderson, Mark

    from the Rosch [1] paper. These search terms were entered into the Google Image search engine in order the ability of subjects to derive the search term that might have been used to return a set of images from on subjects' abilities in this respect. Search terms were defined and images found using an online image

  12. Automatic Eyeglasses Removal from Face Images

    E-Print Network [OSTI]

    Narasayya, Vivek

    Automatic Eyeglasses Removal from Face Images Chenyu Wu, Ce Liu, Heung-Yueng Shum, Member, IEEE an intelligent image editing and face synthesis system that automatically removes eyeglasses from an input frontal face image. Although conventional image editing tools can be used to remove eyeglasses by pixel

  13. BLIND DECONVOLUTION AND DEBLURRING IN IMAGE ANALYSIS

    E-Print Network [OSTI]

    Qiu, Peihua

    BLIND DECONVOLUTION AND DEBLURRING IN IMAGE ANALYSIS Peter Hall 1 and Peihua Qiu 1.2 ABSTRACT. Blind deconvolution problems arise in image analysis when both the extent of image blur, and the true from image data. This is a blind deconvolution problem and is, of course, significantly more

  14. Forensic Imaging and Art Herbert Buckley

    E-Print Network [OSTI]

    Zanibbi, Richard

    Forensic Imaging and Art Herbert Buckley Director, Forensic Imaging, New York State Police 4pm, Wed by the Forensic Imaging Office of the New York State Police are physiognomical (facial) reconstruction of skeletal of Forensic Imaging. Mr. Buckley has been a guest lecturer before the annual conclave of the New York State

  15. Image processing applications in NDE

    SciTech Connect (OSTI)

    Morris, R.A.

    1980-01-01T23:59:59.000Z

    Nondestructive examination (NDE) can be defined as a technique or collection of techniques that permits one to determine some property of a material or object without damaging the object. There are a large number of such techniques and most of them use visual imaging in one form or another. They vary from holographic interferometry where displacements under stress are measured to the visual inspection of an objects surface to detect cracks after penetrant has been applied. The use of image processing techniques on the images produced by NDE is relatively new and can be divided into three general categories: classical image enhancement; mensuration techniques; and quantitative sensitometry. An example is discussed of how image processing techniques are used to nondestructively and destructively test the product throughout its life cycle. The product that will be followed is the microballoon target used in the laser fusion program. The laser target is a small (50 to 100 ..mu..m - dia) glass sphere with typical wall thickness of 0.5 to 6 ..mu..m. The sphere may be used as is or may be given a number of coatings of any number of materials. The beads are mass produced by the millions and the first nondestructive test is to separate the obviously bad beads (broken or incomplete) from the good ones. After this has been done, the good beads must be inspected for spherocity and wall thickness uniformity. The microradiography of the glass, uncoated bead is performed on a specially designed low-energy x-ray machine. The beads are mounted in a special jig and placed on a Kodak high resolution plate in a vacuum chamber that contains the x-ray source. The x-ray image is made with an energy less that 2 keV and the resulting images are then inspected at a magnification of 500 to 1000X. Some typical results are presented.

  16. Understanding User Intentions in Vertical Image Search

    E-Print Network [OSTI]

    Chen, Yuxin

    proposed for solving the image matching problem and object location problem in crowded scenes. Such method was further developed in [Stricker and Orengo, 1995] with improved indexing techniques to color information in dig- ital images. In [Huang et al...-tree, R-tree and its variant R+-tree and R?-tree, are usually not scalable to dimensions higher than 20 [White and Jain, 1996]. 2.2 Image annotation Image annotation or image tagging is an area closely related to image retrieval. Image anno- tation...

  17. Microscopy image segmentation tool: Robust image data analysis

    SciTech Connect (OSTI)

    Valmianski, Ilya, E-mail: ivalmian@ucsd.edu; Monton, Carlos; Schuller, Ivan K. [Department of Physics and Center for Advanced Nanoscience, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States)] [Department of Physics and Center for Advanced Nanoscience, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States)

    2014-03-15T23:59:59.000Z

    We present a software package called Microscopy Image Segmentation Tool (MIST). MIST is designed for analysis of microscopy images which contain large collections of small regions of interest (ROIs). Originally developed for analysis of porous anodic alumina scanning electron images, MIST capabilities have been expanded to allow use in a large variety of problems including analysis of biological tissue, inorganic and organic film grain structure, as well as nano- and meso-scopic structures. MIST provides a robust segmentation algorithm for the ROIs, includes many useful analysis capabilities, and is highly flexible allowing incorporation of specialized user developed analysis. We describe the unique advantages MIST has over existing analysis software. In addition, we present a number of diverse applications to scanning electron microscopy, atomic force microscopy, magnetic force microscopy, scanning tunneling microscopy, and fluorescent confocal laser scanning microscopy.

  18. Image Forensic of Glare Feature for Improving Image Retrieval Using Benford's Law

    E-Print Network [OSTI]

    Doran, Simon J.

    Image Forensic of Glare Feature for Improving Image Retrieval Using Benford's Law Ghulam Qadir proposed technique is novel and has a potential to be an image forensic tool for quick image analysis. I. INTRODUCTION The field of digital image forensics is striving hard to restore the lost trust in digital content

  19. STAR Images: Image gallery from the Solenoidal Tracker at RHIC

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The primary physics task of STAR is to study the formation and characteristics of the quark-gluon plasma (QGP), a state of matter believed to exist at sufficiently high energy densities. STAR consists of several types of detectors, each specializing in detecting certain types of particles or characterizing their motion. These detectors allow final statements to be made about the collision. The gallery of STAR images makes available a small collection of event-generated images from Gold-Beam experiments, a simulation of TCP Drift, and a library of STAR instrument and construction photos. [See also DDE00093

  20. Drug Testing for DOE Positions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in Review: TopEnergy DOEDealingVehicle1 Closing the Circle: TheDraftfor $1.14 PerDrug

  1. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, Jr., David N. (Knoxville, TN); Simpson, Marc L. (Knoxville, TN)

    1997-01-01T23:59:59.000Z

    A miniature lens system that corrects for imaging and chromatic aberrations, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components.

  2. Miniature hybrid optical imaging lens

    DOE Patents [OSTI]

    Sitter, D.N. Jr.; Simpson, M.L.

    1997-10-21T23:59:59.000Z

    A miniature lens system that corrects for imaging and chromatic aberrations is disclosed, the lens system being fabricated from primarily commercially-available components. A first element at the input to a lens housing is an aperture stop. A second optical element is a refractive element with a diffractive element closely coupled to, or formed a part of, the rear surface of the refractive element. Spaced closely to the diffractive element is a baffle to limit the area of the image, and this is closely followed by a second refractive lens element to provide the final correction. The image, corrected for aberrations exits the last lens element to impinge upon a detector plane were is positioned any desired detector array. The diffractive element is fabricated according to an equation that includes, as variables, the design wavelength, the index of refraction and the radius from an optical axis of the lens system components. 2 figs.

  3. Electronic imaging system and technique

    DOE Patents [OSTI]

    Bolstad, J.O.

    1984-06-12T23:59:59.000Z

    A method and system for viewing objects obscurred by intense plasmas or flames (such as a welding arc) includes a pulsed light source to illuminate the object, the peak brightness of the light reflected from the object being greater than the brightness of the intense plasma or flame; an electronic image sensor for detecting a pulsed image of the illuminated object, the sensor being operated as a high-speed shutter; and electronic means for synchronizing the shutter operation with the pulsed light source.

  4. Tunable Imaging Filters in Astronomy

    E-Print Network [OSTI]

    J. Bland-Hawthorn

    2000-06-05T23:59:59.000Z

    While tunable filters are a recent development in night time astronomy, they have long been used in other physical sciences, e.g. solar physics, remote sensing and underwater communications. With their ability to tune precisely to a given wavelength using a bandpass optimized for the experiment, tunable filters are already producing some of the deepest narrowband images to date of astrophysical sources. Furthermore, some classes of tunable filters can be used in fast telescope beams and therefore allow for narrowband imaging over angular fields of more than a degree over the sky.

  5. Multispectral imaging method and apparatus

    DOE Patents [OSTI]

    Sandison, D.R.; Platzbecker, M.R.; Vargo, T.D.; Lockhart, R.R.; Descour, M.R.; Richards-Kortum, R.

    1999-07-06T23:59:59.000Z

    A multispectral imaging method and apparatus are described which are adapted for use in determining material properties, especially properties characteristic of abnormal non-dermal cells. A target is illuminated with a narrow band light beam. The target expresses light in response to the excitation. The expressed light is collected and the target's response at specific response wavelengths to specific excitation wavelengths is measured. From the measured multispectral response the target's properties can be determined. A sealed, remote probe and robust components can be used for cervical imaging. 5 figs.

  6. Gamma-ray Imaging Methods

    SciTech Connect (OSTI)

    Vetter, K; Mihailescu, L; Nelson, K; Valentine, J; Wright, D

    2006-10-05T23:59:59.000Z

    In this document we discuss specific implementations for gamma-ray imaging instruments including the principle of operation and describe systems which have been built and demonstrated as well as systems currently under development. There are several fundamentally different technologies each with specific operational requirements and performance trade offs. We provide an overview of the different gamma-ray imaging techniques and briefly discuss challenges and limitations associated with each modality (in the appendix we give detailed descriptions of specific implementations for many of these technologies). In Section 3 we summarize the performance and operational aspects in tabular form as an aid for comparing technologies and mapping technologies to potential applications.

  7. Chapter 20. Magnetic Resonance Imaging Magnetic Resonance Imaging

    E-Print Network [OSTI]

    , and software training from Siemens Medical Solutions; research funding through the Siemens-MIT Alliance and Technology (HST). 2 Siemens Medical Solutions, Erlangen, Germany. #12;Chapter 20. Magnetic Resonance Imaging, Siemens Medical Solutions, Siemens-MIT Alliance, HST Martinos Catalyst Fund. Project Staff: Audrey P. Fan

  8. Multi-channel medical imaging system

    DOE Patents [OSTI]

    Frangioni, John V

    2013-12-31T23:59:59.000Z

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in the subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.

  9. Interaction networks: From protein functions to drug discovery. A review

    E-Print Network [OSTI]

    Thierry-Mieg, Nicolas

    -IMAG Laboratory, TIMB Team, faculté de médecine, 38706 La Tronche cedex, France Received 22 September 2008 on protein functions, signalling and metabolic pathways, and physiological processes, unraveled the molecular (interactome, transcriptome, phenome, localization) to switch from static to dynamic interaction networks

  10. Upright cone beam CT imaging using the onboard imager

    SciTech Connect (OSTI)

    Fave, Xenia, E-mail: xjfave@mdanderson.org; Martin, Rachael [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)] [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Yang, Jinzhong; Balter, Peter; Court, Laurence [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Carvalho, Luis [Varian Medical Systems, Zug 6303 (Switzerland)] [Varian Medical Systems, Zug 6303 (Switzerland); Pan, Tinsu [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2014-06-15T23:59:59.000Z

    Purpose: Many patients could benefit from being treated in an upright position. The objectives of this study were to determine whether cone beam computed tomography (CBCT) could be used to acquire upright images for treatment planning and to demonstrate whether reconstruction of upright images maintained accurate geometry and Hounsfield units (HUs). Methods: A TrueBeam linac was programmed in developer mode to take upright CBCT images. The gantry head was positioned at 0°, and the couch was rotated to 270°. The x-ray source and detector arms were extended to their lateral positions. The x-ray source and gantry remained stationary as fluoroscopic projections were taken and the couch was rotated from 270° to 90°. The x-ray tube current was normalized to deposit the same dose (measured using a calibrated Farmer ion chamber) as that received during a clinical helical CT scan to the center of a cylindrical, polyethylene phantom. To extend the field of view, two couch rotation scans were taken with the detector offset 15 cm superiorly and then 15 cm inferiorly. The images from these two scans were stitched together before reconstruction. Upright reconstructions were compared to reconstructions from simulation CT scans of the same phantoms. Two methods were investigated for correcting the HUs, including direct calibration and mapping the values from a simulation CT. Results: Overall geometry, spatial linearity, and high contrast resolution were maintained in upright reconstructions. Some artifacts were created and HU accuracy was compromised; however, these limitations could be removed by mapping the HUs from a simulation CT to the upright reconstruction for treatment planning. Conclusions: The feasibility of using the TrueBeam linac to take upright CBCT images was demonstrated. This technique is straightforward to implement and could be of enormous benefit to patients with thoracic tumors or those who find a supine position difficult to endure.

  11. A client management system for criminal justice referrals to drug abuse treatment

    E-Print Network [OSTI]

    Pate, Wayland Gordon

    2012-06-07T23:59:59.000Z

    . These modalities included methadone maintenance (MM), outpatient drug-free (DF), therapeutic community (TC), and short-term detoxification (DT). In a review of findings in 1979, Sel ls described each of the four modalities. Methadone maintenance programs... over the years of research. Therapeutic communities are typically residential, drug-free programs offering 24-hour care and they concentrate on rehabilitation through resocialization of the addict toward more adaptive and productive pursuits. Drug...

  12. Imaging Robot Jonathan Dyssel Stets

    E-Print Network [OSTI]

    with a Command File, a file that contains the coordinates and directions of the robot arm. One of the interfaces and an attached camera. The other interface, programmed in Matlab, controls the calculations of the robot armImaging Robot Jonathan Dyssel Stets Kongens Lyngby 2010 IMM-B.Sc-2010-42 #12;Technical University

  13. Hadamard multimode optical imaging transceiver

    DOE Patents [OSTI]

    Cooke, Bradly J; Guenther, David C; Tiee, Joe J; Kellum, Mervyn J; Olivas, Nicholas L; Weisse-Bernstein, Nina R; Judd, Stephen L; Braun, Thomas R

    2012-10-30T23:59:59.000Z

    Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture.

  14. Quantum Computing, Metrology, and Imaging

    E-Print Network [OSTI]

    Hwang Lee; Pavel Lougovski; Jonathan P. Dowling

    2005-06-17T23:59:59.000Z

    Information science is entering into a new era in which certain subtleties of quantum mechanics enables large enhancements in computational efficiency and communication security. Naturally, precise control of quantum systems required for the implementation of quantum information processing protocols implies potential breakthoughs in other sciences and technologies. We discuss recent developments in quantum control in optical systems and their applications in metrology and imaging.

  15. Imaging Genetics --Towards Discovery Neuroscience

    E-Print Network [OSTI]

    Feng, Jianfeng

    variants that influence measures derived from anatomical or functional brain im- ages, which are in turn related to brain-related illnesses or fundamental cognitive, emotional and behavioral processes a tremendous growth in brain imaging as well as an enor- mous explosion of interest and success in genomics

  16. Dissertation Imaging as Characterization Techniques

    E-Print Network [OSTI]

    Sites, James R.

    Telluride Photovoltaics The goal of increasing the efficiency of solar cell devices is a universal oneDissertation Imaging as Characterization Techniques for Thin-Film Cadmium Telluride Photovoltaics. Increased photovoltaic (PV) performance means an increase in competition with other energy tech- nologies

  17. Image Processing Apr. 16, 2012

    E-Print Network [OSTI]

    Erdem, Erkut

    - The Discrete Fourier transform Log power spectrum #12;Review - The Convolution Theorem · The Fourier frequency components · Fourier (1807): Periodic functions could be represented as a weighted sum of sines and cosines Image courtesy of Technology Review #12;Review - Fourier Transform We want

  18. Covered Product Category: Imaging Equipment

    Broader source: Energy.gov [DOE]

    FEMP provides acquisition guidance and Federal efficiency requirements across a variety of product categories, including imaging equipment, which is covered by the ENERGY STAR® program. Federal laws and requirements mandate that agencies meet these efficiency requirements in all procurement and acquisition actions that are not specifically exempted by law.

  19. E-Print Network 3.0 - anti-inflammatory drug naproxen Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    lists available at ScienceDirect Summary: ; Dextromethorphan, a drug commonly used as cough suppressant; Naproxen and Flurbiprofen, two widespread anti... of Naproxen. This makes...

  20. E-Print Network 3.0 - antipsychotic drug treatment Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Medicine 38 PHARMACOGENETICS OF PARKINSONISM, RIGIDITY, Summary: Fleischhacker, W.W., Meise, U., Gunther, V., and Kurz, M. (1994). Compliance with antipsychotic drug...

  1. E-Print Network 3.0 - antimicrobial drug resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

  2. E-Print Network 3.0 - antimicrobial drug resistanceestudio Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

  3. E-Print Network 3.0 - aetiology antimicrobial drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Collection: Environmental Sciences and Ecology 3 Biological, temporal and spatial data on human EID events were Summary: Methods: Data Analysis A map of drug...

  4. E-Print Network 3.0 - anticancer drug cisplatin Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on mitochondrial oxygen consumption Abdul-Kader Souida... June 2003 Abstract The evolving role of mitochondria as a target for many anticancer drugs (e... DNA platination by...

  5. E-Print Network 3.0 - acetaminophen drug particles Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3945 Contents lists available at ScienceDirect Summary: ; Lee, 2007; Mullier et al., 1991). Measurements of the friction between drug and excipient particles... the conveying,...

  6. E-Print Network 3.0 - anti-malarial drug precursor Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

  7. E-Print Network 3.0 - anti-malarial drug quality Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

  8. E-Print Network 3.0 - anti-malarial drug sensitivity Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JAMES RENNIE BEQUEST REPORT ON EXPEDITIONPROJECTCONFERENCE Summary: torch and hiking boots. 110 - Insurance. 80 - Vaccinations, anti-malarial drugs and medical supplies...

  9. E-Print Network 3.0 - adverse drug interactions Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences and Ecology 12 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: ; Early labels decorative Drug...

  10. E-Print Network 3.0 - antibacterial drug resistances Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Exposing plasmids as the Achilles' heel of drug-resistant bacteria Summary: in the pharmaceutical industry away from the development of novel antibacterials 4,5. New...

  11. E-Print Network 3.0 - anti-infective drugs advisory Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    drug classes of anti-infectives and their mechanisms of action... advisory role or in the pharmaceutical industry. An interest in antibiotic prescribing practice... changes to...

  12. E-Print Network 3.0 - anticholinergic antiparkinson drugs Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 5 > >> 1 Arch Intern Med . Author manuscript Drugs with anticholinergic properties, cognitive decline, and dementia in Summary: Arch Intern Med . Author manuscript Page 1 14...

  13. E-Print Network 3.0 - antiviral drug acyclovir Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Medicine 3 European consensus on viral encephalitis Herpes simplex encephalitis (HSE) is one of the Summary: management, HSE does respond to specific antiviral drugs, and...

  14. E-Print Network 3.0 - anticancer drug delivery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

  15. E-Print Network 3.0 - anticancer drug targets Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

  16. E-Print Network 3.0 - antiepileptic drugs compelling Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    compelling Search Powered by Explorit Topic List Advanced Search Sample search results for: antiepileptic drugs compelling Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth...

  17. E-Print Network 3.0 - antiepileptic drugs increase Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    increase Search Powered by Explorit Topic List Advanced Search Sample search results for: antiepileptic drugs increase Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth...

  18. E-Print Network 3.0 - anti-hiv drug regimens Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    body's natural anti-HIV immune... , there are no therapeutic HIV vaccines approved by the Food and DrugAdministration (FDA). However, therapeutic HIV vaccines... response, people...

  19. E-Print Network 3.0 - animal drug availability Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: of various origins (e.g. viral hepatitis; chronic intoxication by alcohol, chemicals or drugs; Wilson... architecture and hepatic organ function. Up till now, no...

  20. E-Print Network 3.0 - anticancer drug ellipticine Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute, University of Toronto Collection: Biology and Medicine 15 Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang Summary: in drug discovery...

  1. E-Print Network 3.0 - anticancer drug discovery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 From the University of Mississippi Medical Center Division of Public Affairs ANTI-CANCER DRUG DISCOVERY PARTNERSHIP FORMED BETWEEN UMMC CANCER INSTITUTE AND Summary: From the...

  2. E-Print Network 3.0 - adrs adverse drug Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences and Ecology 29 List of publications related to pharmavovigilance Summary: , Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin...

  3. E-Print Network 3.0 - antihypertensive drug treatment Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the medical treatment of vascular risk factors. Cardiovasc Drugs Ther 2005 Dec... , Stricker BHC, Leufkens HGM, de Boer A. Methods to assess intended effects of ... Source:...

  4. E-Print Network 3.0 - antimalaria drug mefloquine Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EP van, Heeringa M. Bijwerkingen van mefloquine. Onrust ondermijnt objectieve... , Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin...

  5. antiparkinsonian drug-induced sleepiness: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lpez-ortega; M Carmen Lpez-vega; M Isabel Lucena; Clinical Pharmacology Service; Virgen De La 35 Drug-induced pruritic micropapular eruption: anastrozole, a commonly used...

  6. E-Print Network 3.0 - atovaquone drug resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    spontaneously arising muta- tions that confer resistance to the drug 39. In principle... the molecular basis of atovaquone resistance in parasites and ... Source: Trumpower,...

  7. Direct encapsulation of water-soluble drug into silica microcapsules for sustained release applications

    SciTech Connect (OSTI)

    Wang Jiexin; Wang Zhihui [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Chen Jianfeng [Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029 (China); Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: chenjf@mail.buct.edu.cn; Yun, Jimmy [Nanomaterials Technology Pte. Ltd., 28 Ayer Rajah Crescent 03-03, Singapore 139959 (Singapore)

    2008-12-01T23:59:59.000Z

    Direct encapsulation of water-soluble drug into silica microcapsules was facilely achieved by a sol-gel process of tetraethoxysilane (TEOS) in W/O emulsion with hydrochloric acid (HCl) aqueous solution containing Tween 80 and drug as well as cyclohexane solution containing Span 80. Two water-soluble drugs of gentamicin sulphate (GS) and salbutamol sulphate (SS) were chosen as model drugs. The characterization of drug encapsulated silica microcapsules by scanning electronic microscopy (SEM), FTIR, thermogravimetry (TG) and N{sub 2} adsorption-desorption analyses indicated that drug was successfully entrapped into silica microcapsules. The as-prepared silica microcapsules were uniform spherical particles with hollow structure, good dispersion and a size of 5-10 {mu}m, and had a specific surface area of about 306 m{sup 2}/g. UV-vis and thermogravimetry (TG) analyses were performed to determine the amount of drug encapsulated in the microcapsules. The BJH pore size distribution (PSD) of silica microcapsules before and after removing drug was examined. In vitro release behavior of drug in simulated body fluid (SBF) revealed that such system exhibited excellent sustained release properties.

  8. E-Print Network 3.0 - antithyroid drugs Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Perchlorate Drugs like tamoxifen, nafoxidine Persistent organic pollutants such as dioxins... water sup- plies have measurable levels of residues from various prescription...

  9. anti-hiv drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  10. anti-parkinsonian drug therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EVIDENCE BASED DRUG THERAPY RESOURCE CiteSeer Summary: Management of acute and chronic gout is challenging in the setting of chronic kidney disease (CKD). Common gout treatments...

  11. E-Print Network 3.0 - anti-tuberculosis drug resistance Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    University Collection: Biology and Medicine 10 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

  12. E-Print Network 3.0 - anti-inflammatory drug-induced ulcer Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    << < 1 2 3 4 5 > >> Page: << < 1 2 3 4 5 > >> 61 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: episodic arthritis, which...

  13. E-Print Network 3.0 - anti-inflammatory drug etoricoxib Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vanderbilt University Collection: Biology and Medicine ; Chemistry 4 Management of gout Chapter 2.1 Summary: - inflammatory drugs (glucocorticosteroids, colchicine, and...

  14. E-Print Network 3.0 - anti-tuberculosis drug ethionamide Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Harvard University Collection: Biology and Medicine 5 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: was undergoing a course of...

  15. E-Print Network 3.0 - antituberculosis drug resistance Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    British Columbia Collection: Biology and Medicine 12 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

  16. E-Print Network 3.0 - antituberculosis drugs carriers Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Harvard University Collection: Biology and Medicine 3 Practice research in the field of gout Clinical pharmacology of antihyperuricemic drugs Summary: Practice research in the...

  17. TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

    E-Print Network [OSTI]

    Chen, Yu-Chian

    Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional ...

  18. E-Print Network 3.0 - antiepileptic drugs carbamazepine Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for: antiepileptic drugs carbamazepine Page: << < 1 2 3 4 5 > >> 1 Folic acid sensitive birth defects in association with intrauterine exposure to folic acid Summary: to...

  19. Reporting Prescription Drugs, Over-the-Counter Medications, and Dietary Supplements

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2008-02-01T23:59:59.000Z

    Overview of types of prescription drugs and over-the-counter medications that must be reported in DOE's Human Reliability Program.

  20. E-Print Network 3.0 - alphavirus antiviral drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that depends on the PARP domain may guide future strategies for therapeutic drug design to treat alphavirus... -finger antiviral protein inhibits alphavirus ... Source:...

  1. E-Print Network 3.0 - antiplatelet drugs resistance Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to microscopy development, bioengineering to drug design use Jennifer's talk as a guide to illustrate uses... thinners taken by mouth may be prescribed later to prevent clots...

  2. E-Print Network 3.0 - antiviral drug design Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Pharmacology and Pharmaceutical Sciences. his research interests include drug design and discovery, database mining of small- Summary: an internationally recognized...

  3. Adverse Drug Reaction Monitoring In Psychiatric OPD Adverse Drug Reaction Monitoring In Psychiatric Outpatient Department Of A Tertiary Care Hospital

    E-Print Network [OSTI]

    Hiren K. Prajapati; Nisarg D. Joshi; Hiren R. Trivedi; Manubhai C. Parmar; Shilpa P. Jadav; Dinesh M. Parmar; Jalpan G. Kareliya

    Abstracts Background:Pharmacovigilance in psychiatry units can play vital role in detecting adverse drug reactions (ADRs) and alerting physician to such events, thereby protecting the user population from avoidable harm. Objective: To assess the suspected ADRs profile of psychotropic drugs in psychiatry OPD of a tertiary care hospital and its comparison with available literature data as well as to create awareness among the consultant psychiatrists to these ADRs profile. Materials and Methods: A prospective study was conducted in the psychiatry OPD. Thirty five consecutive patients per day were screened irrespective of their psychiatric diagnosis for suspected ADRs on 3 fixed days in a week from January 2011 to December 2011. CDSCO form was used to record the ADRs. Causality was assessed by WHO causality assessment scale while severity was assessed using Hartwig and Siegel scale. Results: Out of 4410 patients were screened, 383 patients were suspected of having at least one ADR. Thus, 8.68 % of our study population reported ADRs. Of 407 events recorded, 369(90.60%) were “probable ” and rest “possible ” according to WHO-UMC causality assessment

  4. angiographic image segmentation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Image segmentation is very essential and critical to image processing and pattern recognition. This survey provides a summary of color image segmentation techniques...

  5. Search Log Analysis of the ARTstor Cultural Heritage Image Database

    E-Print Network [OSTI]

    Lowe, Heather Ann

    2013-01-01T23:59:59.000Z

    Patterns in a Digital Image Database. Information RetrievalCultural Heritage Image Database A thesis submitted inCultural Heritage Image Database by Heather Ann Lowe Master

  6. MAUI: Modeling, Analysis, and Ultrafast Imaging | Argonne National...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Data Science Modeling and Simulation Multimodal Imaging MAUI: Modeling, Analysis, and Ultrafast Imaging MAUI: Modeling, Analysis, and Ultrafast Imaging Project Goals...

  7. Non-Destructive Neutron Imaging to Analyze Particulate Filters...

    Broader source: Energy.gov (indexed) [DOE]

    Non-Destructive Neutron Imaging to Analyze Particulate Filters Non-Destructive Neutron Imaging to Analyze Particulate Filters Non-destructive, non-invasive imaging is being...

  8. Image fusion for a nighttime driving display

    E-Print Network [OSTI]

    Herrington, William Frederick

    2005-01-01T23:59:59.000Z

    An investigation into image fusion for a nighttime driving display application was performed. Most of the image fusion techniques being investigated in this application were developed for other purposes. When comparing the ...

  9. Iterative synthetic aperture radar imaging algorithms 

    E-Print Network [OSTI]

    Kelly, Shaun Innes

    2014-06-30T23:59:59.000Z

    Synthetic aperture radar is an important tool in a wide range of civilian and military imaging applications. This is primarily due to its ability to image in all weather conditions, during both the day and the night, ...

  10. Image sense disambiguation : a multimodal approach

    E-Print Network [OSTI]

    Saenko, Ekaterina, 1976-

    2009-01-01T23:59:59.000Z

    If a picture is worth a thousand words, can a thousand words be worth a training image? Most successful object recognition algorithms require manually annotated images of objects to be collected for training. The amount ...

  11. Predicting gene function from images of cells

    E-Print Network [OSTI]

    Jones, Thouis Raymond, 1971-

    2007-01-01T23:59:59.000Z

    This dissertation shows that biologically meaningful predictions can be made by analyzing images of cells. In particular, groups of related genes and their biological functions can be predicted using images from large ...

  12. Foreword,xiii SECTION 1:BASIC IMAGING

    E-Print Network [OSTI]

    Guide: Imaging Synaptogenesis by Measuring Accumulation of Synaptic Proteins, 225 C. Dean and F! Scheiffele A Practical Guide: Imaging Retinotectal Synaptic Connectivity,229 S. Cohen-Corey A Practical Guide

  13. Lensless X-Ray Imaging in Reflection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    X-Ray Imaging in Reflection Print The advent of x-ray free-electron laser (XFEL) light sources has led to an outburst of research activities in the field of lensless imaging. XFELs...

  14. Imaging the High Energy Cosmic Ray Sky

    E-Print Network [OSTI]

    Haviland, David

    Imaging the High Energy Cosmic Ray Sky PETTER HOFVERBERG Licentiate Thesis Stockholm, Sweden 2006 #12;#12;Licentiate Thesis Imaging the High Energy Cosmic Ray Sky Petter Hofverberg Particle

  15. Automatic caption generation for news images 

    E-Print Network [OSTI]

    Feng, Yansong

    2011-06-30T23:59:59.000Z

    This thesis is concerned with the task of automatically generating captions for images, which is important for many image-related applications. Automatic description generation for video frames would help security ...

  16. Lensless X-Ray Imaging in Reflection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lensless X-Ray Imaging in Reflection Lensless X-Ray Imaging in Reflection Print Wednesday, 26 October 2011 00:00 The advent of x-ray free-electron laser (XFEL) light sources has...

  17. BIOMEDICAL MATHEMATICS: Promising Directions in Imaging,

    E-Print Network [OSTI]

    Censor, Yair

    BIOMEDICAL MATHEMATICS: Promising Directions in Imaging, Therapy Planning, and Inverse Problems #12;BIOMEDICAL MATHEMATICS: Promising Directions in Imaging, Therapy Planning, and Inverse Problems Yair Censor, Ming Jiang, Ge Wang Editors The Huangguoshu International Interdisciplinary Conference on Biomedical

  18. Image upload with broken thumbnail image | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Power BasicsGermany:Information IDSDloomis's picture Submitted byImage

  19. Automated Microarray Image Analysis Toolbox for MATLAB

    SciTech Connect (OSTI)

    White, Amanda M.; Daly, Don S.; Willse, Alan R.; Protic, Miroslava; Chandler, Darrell P.

    2005-09-01T23:59:59.000Z

    The Automated Microarray Image Analysis (AMIA) Toolbox for MATLAB is a flexible, open-source microarray image analysis tool that allows the user to customize analysis of sets of microarray images. This tool provides several methods of identifying and quantify spot statistics, as well as extensive diagnostic statistics and images to identify poor data quality or processing. The open nature of this software allows researchers to understand the algorithms used to provide intensity estimates and to modify them easily if desired.

  20. Method for imaging a concealed object

    DOE Patents [OSTI]

    Davidson, James R [Idaho Falls, ID; Partin, Judy K [Idaho Falls, ID; Sawyers, Robert J [Idaho Falls, ID

    2007-07-03T23:59:59.000Z

    A method for imaging a concealed object is described and which includes a step of providing a heat radiating body, and wherein an object to be detected is concealed on the heat radiating body; imaging the heat radiating body to provide a visibly discernible infrared image of the heat radiating body; and determining if the visibly discernible infrared image of the heat radiating body is masked by the presence of the concealed object.

  1. SEISMIC IMAGING WITH THE GENERALIZED RADON ...

    E-Print Network [OSTI]

    2008-07-29T23:59:59.000Z

    SEISMIC IMAGING WITH THE GENERALIZED RADON. TRANSFORM AND DOUBLE BEAMFORMING: A CURVELET. TRANSFORM PERSPECTIVE. M V DE ...

  2. Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery

    E-Print Network [OSTI]

    Vukmirovic, Neda

    2007-01-01T23:59:59.000Z

    Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

  3. Fast neutron imaging device and method

    DOE Patents [OSTI]

    Popov, Vladimir; Degtiarenko, Pavel; Musatov, Igor V.

    2014-02-11T23:59:59.000Z

    A fast neutron imaging apparatus and method of constructing fast neutron radiography images, the apparatus including a neutron source and a detector that provides event-by-event acquisition of position and energy deposition, and optionally timing and pulse shape for each individual neutron event detected by the detector. The method for constructing fast neutron radiography images utilizes the apparatus of the invention.

  4. Photogrammetry & Machine Vision 1. Image sensors

    E-Print Network [OSTI]

    Giger, Christine

    Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image'Apuzzo Photogrammetry and Machine Vision - 3 Point cloud processing, surface generation, texturing (b) Camera, noise) 2N. D'Apuzzo Photogrammetry and Machine Vision - 3 Point cloud processing, surface generation

  5. Photogrammetry & Machine Vision 1. Image sensors

    E-Print Network [OSTI]

    Giger, Christine

    Photogrammetry & Machine Vision 1. Image sensors (a) Fundamentals of image sensors (b) CCD image. Remondino, N. D'Apuzzo Photogrammetry and Machine Vision ­ 2. Camera calibration and orientation (b) Camera and Machine Vision ­ 2. Camera calibration and orientation (b) Calibration methods (reference object, point

  6. Composite ultrasound imaging apparatus and method

    DOE Patents [OSTI]

    Morimoto, A.K.; Bow, W.J. Jr.; Strong, D.S.; Dickey, F.M.

    1998-09-15T23:59:59.000Z

    An imaging apparatus and method for use in presenting composite two dimensional and three dimensional images from individual ultrasonic frames. A cross-sectional reconstruction is applied by using digital ultrasound frames, transducer orientation and a known center. Motion compensation, rank value filtering, noise suppression and tissue classification are utilized to optimize the composite image. 37 figs.

  7. Composite ultrasound imaging apparatus and method

    DOE Patents [OSTI]

    Morimoto, Alan K. (Albuquerque, NM); Bow, Jr., Wallace J. (Albuquerque, NM); Strong, David Scott (Albuquerque, NM); Dickey, Fred M. (Albuquerque, NM)

    1998-01-01T23:59:59.000Z

    An imaging apparatus and method for use in presenting composite two dimensional and three dimensional images from individual ultrasonic frames. A cross-sectional reconstruction is applied by using digital ultrasound frames, transducer orientation and a known center. Motion compensation, rank value filtering, noise suppression and tissue classification are utilized to optimize the composite image.

  8. THE ROLE OF IMAGE REGISTRATION BRAIN MAPPING

    E-Print Network [OSTI]

    Thompson, Paul

    1 THE ROLE OF IMAGE REGISTRATION IN BRAIN MAPPING Arthur W. Toga and Paul Thompson Laboratory of Neuro Imaging, Dept. of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, CA-5518 E-mail: thompson@loni.ucla.edu #12;2 THE ROLE OF IMAGE REGISTRATION IN BRAIN MAPPING Arthur W. Toga

  9. Improved Image Fusion Using Balanced Multiwavelets

    E-Print Network [OSTI]

    Ghouti, Lahouari

    Improved Image Fusion Using Balanced Multiwavelets Lahouari Ghouti, Ahmed Bouridane and Mohammad K. Ibrahim Abstract-- This paper presents the use of balanced multi- wavelets for image fusion. The proposed image fusion scheme incorporates the use of balanced multiwavelets transform, which uses multiple

  10. Chemical Imaging Initiative Delivering New Capabilities for

    E-Print Network [OSTI]

    Chemical Imaging Initiative Delivering New Capabilities for In Situ, Molecular-Scale Imaging A complete, precise and realistic view of chemical, materials and biochemical processes and an understanding sources and mathematical models. At Pacific Northwest National Laboratory, the Chemical Imaging Initiative

  11. 3D Imaging Of Wet Granular Matter

    E-Print Network [OSTI]

    Anlage, Steven

    3D Imaging Of Wet Granular Matter Leonard Goff Advisor: Dr. Wolfgang Losert With Application to Penetrometer Insertion #12;3D Imaging Of Wet Granular Matter Leonard Goff, Advisor: Dr. Wolfgang Losert CoffeeSand Gravel Oops! #12;3D Imaging Of Wet Granular Matter Leonard Goff, Advisor: Dr. Wolfgang Losert

  12. Reconstruction and Restoration of PET Images.

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Reconstruction and Restoration of PET Images. Ph.D. Thesis Peter Alshede Philipsen LYNGBY 1998 IMM with reconstruction and restoration of Positron Emission Tomography (PET) images carried out at the Section of Digital contains a short introduction to PET imaging. The second part, chapters 2 to 4, describe the PET scanner

  13. HDR CFA IMAGE RENDERING David Alleysson,1

    E-Print Network [OSTI]

    Alleysson, David

    HDR CFA IMAGE RENDERING David Alleysson,1 Laurence Meylan,2 and Sabine S¨usstrunk2 1Laboratory of the already demosaiced image. This render- ing is closer to retinal processing where an image is acquired framework, demosaicing is the final step of the rendering. Our method, inspired by retinal sampling

  14. COMPUTATIONAL IMAGING Berthold K.P. Horn

    E-Print Network [OSTI]

    Treuille, Adrien

    Ziock, and Lorenzo Fabris. #12;Coded Aperture Imaging · Can't refract or reflect gamma rays · Pinhole Principle #12;Decoding Method Rationale #12;Coded Aperture Imaging · Can't refract or reflect gamma rays Squares Match in FT #12;Polystyrene Micro Beads (1µm) #12;#12;(2) CODED APERTURE IMAGING · Can't refract

  15. Nuclide Imaging: Planar Scintigraphy, SPECT, PET

    E-Print Network [OSTI]

    Suel, Torsten

    : energy of each photon 2 4 r AE I = #12;EL5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 9 by Prince. Figures are from the textbook except otherwise noted. #12;EL5823 Nuclear Imaging Yao Wang5823 Nuclear Imaging Yao Wang, Polytechnic U., Brooklyn 3 What is Nuclear Medicine · Also known

  16. Supplemental Material for "Efficient MR Image Reconstruction for Compressed MR Imaging"

    E-Print Network [OSTI]

    Huang, Junzhou

    D MR images: cardiac, brain, chest and artery respectively. Figure 1, 2, 3 and 4 shows the visual complexity. (a) (b) (c) (d) (e) (f) Fig. 1. Cardiac MR image reconstruction from 20% sampling (a) OriginalSupplemental Material for "Efficient MR Image Reconstruction for Compressed MR Imaging" Paper ID

  17. High-contrast imaging testbed

    SciTech Connect (OSTI)

    Baker, K; Silva, D; Poyneer, L; Macintosh, B; Bauman, B; Palmer, D; Remington, T; Delgadillo-Lariz, M

    2008-01-23T23:59:59.000Z

    Several high-contrast imaging systems are currently under construction to enable the detection of extra-solar planets. In order for these systems to achieve their objectives, however, there is considerable developmental work and testing which must take place. Given the need to perform these tests, a spatially-filtered Shack-Hartmann adaptive optics system has been assembled to evaluate new algorithms and hardware configurations which will be implemented in these future high-contrast imaging systems. In this article, construction and phase measurements of a membrane 'woofer' mirror are presented. In addition, results from closed-loop operation of the assembled testbed with static phase plates are presented. The testbed is currently being upgraded to enable operation at speeds approaching 500 hz and to enable studies of the interactions between the woofer and tweeter deformable mirrors.

  18. Dynamic imaging with electron microscopy

    SciTech Connect (OSTI)

    Campbell, Geoffrey; McKeown, Joe; Santala, Melissa

    2014-02-20T23:59:59.000Z

    Livermore researchers have perfected an electron microscope to study fast-evolving material processes and chemical reactions. By applying engineering, microscopy, and laser expertise to the decades-old technology of electron microscopy, the dynamic transmission electron microscope (DTEM) team has developed a technique that can capture images of phenomena that are both very small and very fast. DTEM uses a precisely timed laser pulse to achieve a short but intense electron beam for imaging. When synchronized with a dynamic event in the microscope's field of view, DTEM allows scientists to record and measure material changes in action. A new movie-mode capability, which earned a 2013 R&D 100 Award from R&D Magazine, uses up to nine laser pulses to sequentially capture fast, irreversible, even one-of-a-kind material changes at the nanometer scale. DTEM projects are advancing basic and applied materials research, including such areas as nanostructure growth, phase transformations, and chemical reactions.

  19. Interpreting atomic resolution spectroscopic images

    SciTech Connect (OSTI)

    Oxley, Mark P [ORNL; Varela del Arco, Maria [ORNL; Pennycook, Timothy J [ORNL; van Benthem, Klaus [ORNL; Findlay, Scott D. [University of Melbourne, Australia; Allen, L. J. [University of Melbourne, Australia; Pennycook, Stephen J [ORNL

    2007-01-01T23:59:59.000Z

    Core-loss electron energy loss spectroscopy is a powerful experimental tool providing information about electronic structure essential for understanding the properties of new and emerging materials. Here we show that the shape and width of spectroscopic images do not show a simple variation with binding energy, as commonly assumed. Rather they exhibit a complex dependence on the effective nonlocal scattering potential, and also on the dynamical channeling and absorption of the incident probe through the specimen. Consequently, in LaMnO$_3$, the low lying La N$_{4,5}$ edge at 99 eV can produce images of similar width to higher lying edges such as the O $K$ edge at 532 eV.

  20. Dynamic imaging with electron microscopy

    ScienceCinema (OSTI)

    Campbell, Geoffrey; McKeown, Joe; Santala, Melissa

    2014-05-30T23:59:59.000Z

    Livermore researchers have perfected an electron microscope to study fast-evolving material processes and chemical reactions. By applying engineering, microscopy, and laser expertise to the decades-old technology of electron microscopy, the dynamic transmission electron microscope (DTEM) team has developed a technique that can capture images of phenomena that are both very small and very fast. DTEM uses a precisely timed laser pulse to achieve a short but intense electron beam for imaging. When synchronized with a dynamic event in the microscope's field of view, DTEM allows scientists to record and measure material changes in action. A new movie-mode capability, which earned a 2013 R&D 100 Award from R&D Magazine, uses up to nine laser pulses to sequentially capture fast, irreversible, even one-of-a-kind material changes at the nanometer scale. DTEM projects are advancing basic and applied materials research, including such areas as nanostructure growth, phase transformations, and chemical reactions.

  1. Medical imaging with coded apertures

    SciTech Connect (OSTI)

    Keto, E.; Libby, S.

    1995-06-16T23:59:59.000Z

    Now algorithms were investigated for image reconstruction in emission tomography which could incorporate complex instrumental effects such as might be obtained with a coded aperture system. The investigation focused on possible uses of the wavelet transform to handle non-stationary instrumental effects and analytic continuation of the Radon transform to handle self-absorption. Neither investigation was completed during the funding period and whether such algorithms will be useful remains an open question.

  2. Document Imaging | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehicles » AlternativeUp HomeHorseDOECybersecurityDocument Imaging Document

  3. Hyperspectral Imaging | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Power BasicsGermany: EnergyPowerInformationHomerHydrogen CompaniesImaging

  4. Image compression/decompression based on mathematical transform, reduction/expansion, and image sharpening

    DOE Patents [OSTI]

    Fu, C.Y.; Petrich, L.I.

    1997-12-30T23:59:59.000Z

    An image represented in a first image array of pixels is first decimated in two dimensions before being compressed by a predefined compression algorithm such as JPEG. Another possible predefined compression algorithm can involve a wavelet technique. The compressed, reduced image is then transmitted over the limited bandwidth transmission medium, and the transmitted image is decompressed using an algorithm which is an inverse of the predefined compression algorithm (such as reverse JPEG). The decompressed, reduced image is then interpolated back to its original array size. Edges (contours) in the image are then sharpened to enhance the perceptual quality of the reconstructed image. Specific sharpening techniques are described. 22 figs.

  5. Radiation-tolerant imaging device

    DOE Patents [OSTI]

    Colella, N.J.; Kimbrough, J.R.

    1996-11-19T23:59:59.000Z

    A barrier at a uniform depth for an entire wafer is used to produce imaging devices less susceptible to noise pulses produced by the passage of ionizing radiation. The barrier prevents charge created in the bulk silicon of a CCD detector or a semiconductor logic or memory device from entering the collection volume of each pixel in the imaging device. The charge barrier is a physical barrier, a potential barrier, or a combination of both. The physical barrier is formed by an SiO{sub 2} insulator. The potential barrier is formed by increasing the concentration of majority carriers (holes) to combine with the electron`s generated by the ionizing radiation. A manufacturer of CCD imaging devices can produce radiation-tolerant devices by merely changing the wafer type fed into his process stream from a standard wafer to one possessing a barrier beneath its surface, thus introducing a very small added cost to his production cost. An effective barrier type is an SiO{sub 2} layer. 7 figs.

  6. VLBI Imaging of Seyfert Galaxies

    E-Print Network [OSTI]

    James S. Ulvestad

    2003-01-05T23:59:59.000Z

    The advent of the Very Long Baseline Array and its phase-referencing capability have enabled milliarcsecond-scale imaging of radio sources at sub-millijansky sensitivity, opening the door to high-resolution imaging of Seyfert galaxies. Over the last few years, this has led to a number of interesting new results that shed light on the characteristics of the inner cores of Seyfert galaxies. These include the following: (1) classical Seyfert galaxies with steep radio spectra have a strong tendency to exhibit radio jets at milliarcsecond scales, sometimes with considerable curvature in the jets; (2) apparent speeds of jets imaged at multiple epochs generally are considerably less than c, often in the vicinity of 0.1c or less, although there sometimes are faster motions seen after strong outbursts; and (3) lower luminosity Seyfert galaxies have a much stronger tendency to show flat or somewhat inverted radio spectra, usually are unresolved on milliarcsecond scales, and probably are dominated by a combination of low-radiative-efficiency accretion flows and very compact radio jets. This paper discusses some examples that illustrate these properties, and summarizes some of what we have learned about weak active galaxies on milliarcsecond scales.

  7. Data Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song

    E-Print Network [OSTI]

    Song, Il-Yeol

    an analysis of the principal activities involved in drug discovery in the pharmaceutical industry, and a setData Warehouse Design for Pharmaceutical Drug Discovery Research Melinda G. Axel and Il-Yeol Song: axel@superlink.net, songiy@post.drexel.edu Abstract Pharmaceutical companies spend billions of dollars

  8. Blood Brain Barrier group Multi drug resistance and P-glycoprotein efflux transporter: physiological roles and

    E-Print Network [OSTI]

    Applebaum, David

    1 Blood Brain Barrier group Multi drug resistance and P-glycoprotein efflux transporter-binding cassette) transporter family expressed in many tissue barriers (e.g. gut, lung, blood-brain barrier of many drugs to the brain and has been the subject of intensive research in the last 10 years

  9. Optimal periodic control of a drug delivery system Subbarao Varigonda 1

    E-Print Network [OSTI]

    Georgiou, Tryphon T.

    drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

  10. Techniques to Improve the Characterization of Protein Particles in Biologic Drug Products

    E-Print Network [OSTI]

    Toler, Maria

    2012-08-31T23:59:59.000Z

    are the characterization of these particles using material sparing approaches and the effect of the presence of silicone oil particles on protein solutions. With the focus on high concentration drug products (ˇÝ50 mg/mL), and the drive toward conserving drug product...

  11. Endovascular Treatment of a Vertebral Artery Pseudoaneurysm in a Drug User

    SciTech Connect (OSTI)

    Mourikis, Dimitrios; Chatziioannou, Achilleas; Doriforou, Ortansia; Skiadas, Vasilios, E-mail: bill_skiadas@yahoo.gr; Koutoulidis, Vasilios [Areteion Hospital, University of Athens, Department of Radiology (Greece); Katsenis, Konstantinos [Areteion Hospital, University of Athens, Department of Vascular Surgery (Greece); Vlahos, Lampros [Areteion Hospital, University of Athens, Department of Radiology (Greece)

    2006-08-15T23:59:59.000Z

    A 26-year-old drug abuser who presented with sepsis was found to have a pseudoaneurysm in the left vertebral artery. This aneurysm was presumed to be post-traumatic, since the patient reported multiple attempts to inject drugs in the left jugular vein 15 days prior to admission. The pseudoaneurysm was treated effectively with stent-graft placement.

  12. Image Resolution in Scanning Transmission Electron Microscopy

    SciTech Connect (OSTI)

    Pennycook, S. J.; Lupini, A.R.

    2008-06-26T23:59:59.000Z

    Digital images captured with electron microscopes are corrupted by two fundamental effects: shot noise resulting from electron counting statistics and blur resulting from the nonzero width of the focused electron beam. The generic problem of computationally undoing these effects is called image reconstruction and for decades has proved to be one of the most challenging and important problems in imaging science. This proposal concerned the application of the Pixon method, the highest-performance image-reconstruction algorithm yet devised, to the enhancement of images obtained from the highest-resolution electron microscopes in the world, now in operation at Oak Ridge National Laboratory.

  13. Collaborative Initiative in Biomedical Imaging to Study Complex Diseases

    SciTech Connect (OSTI)

    Lin, Weili [The University of North Carolina at Chapel Hill; Fiddy, Michael A. [The University of North Carolina at Charlotte

    2012-03-31T23:59:59.000Z

    The work reported addressed these topics: Fluorescence imaging; Optical coherence tomography; X-ray interferometer/phase imaging system; Quantitative imaging from scattered fields, Terahertz imaging and spectroscopy; and Multiphoton and Raman microscopy.

  14. Image display device in digital TV

    DOE Patents [OSTI]

    Choi, Seung Jong (Seoul, KR)

    2006-07-18T23:59:59.000Z

    Disclosed is an image display device in a digital TV that is capable of carrying out the conversion into various kinds of resolution by using single bit map data in the digital TV. The image display device includes: a data processing part for executing bit map conversion, compression, restoration and format-conversion for text data; a memory for storing the bit map data obtained according to the bit map conversion and compression in the data processing part and image data inputted from an arbitrary receiving part, the receiving part receiving one of digital image data and analog image data; an image outputting part for reading the image data from the memory; and a display processing part for mixing the image data read from the image outputting part and the bit map data converted in format from the a data processing part. Therefore, the image display device according to the present invention can convert text data in such a manner as to correspond with various resolution, carry out the compression for bit map data, thereby reducing the memory space, and support text data of an HTML format, thereby providing the image with the text data of various shapes.

  15. Image

    Broader source: Energy.gov (indexed) [DOE]

    Domestic Source Recovery- FY 2013 Program or Field Office: Los Alamos Site Office (DOENNSA) Locationls) ICityCountyState): Los Alamos, NM Proposed Action Description: Submit by...

  16. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LEFT BLANK B-3 DOCUMENTS REVIEWED * BJCPAD-427 R7, Hazard Analysis for the C-746-Q Hazardous and Low-Level Waste Storage Facility Paducah Gaseous Diffusion Plant, Paducah,...

  17. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... 17 L-4e Statistical Analysis of Laboratory Analytical Data ... 17 L-4e(1) Temporal and Spatial...

  18. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    are based on South's (1977) Method and Theory in Historical Archeology, but include an expanded list of categories. It should be noted that technical guidance from OHPO staff...

  19. Image

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNationalRestart of the Review of theOFFICEACMEFUTURE MOBILITY INPROCEEDINGS,Los

  20. Image

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNationalRestart of the Review of theOFFICEACMEFUTURE MOBILITY INPROCEEDINGS,Los

  1. Image

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNationalRestart of the Review of theOFFICEACMEFUTURE MOBILITY INPROCEEDINGS,Los

  2. Image

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana.ProgramJulietipDepartment of Energy MediaRequirements ofPaulThe

  3. Image

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou$0.C. 20545*. . : '*I_ - I _ _ _ _ --~ ._----. -

  4. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLCBasicsScience atIanIgorIlya Prigogine, Chaos,

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    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

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    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

  7. Image

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

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    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

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    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

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    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel CellandVehicles &StandardsEnergy1 U.S.

  11. Image

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartmentNational NuclearhasAdministration77Nuclear SecurityFAPAC-NMNRC 741No. M202I.ITEM

  12. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi

  13. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D CODE

  14. Image

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  15. Image

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  16. Image

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  17. Image

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  18. Image

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  19. Image

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  20. Image

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  1. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  2. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!D

  3. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!DMA RTINEZ

  4. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!DMA RTINEZJOH

  5. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi CONTRACT!DMA

  6. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: Fermi

  7. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: FermiSliSANA MARTINEZ

  8. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: FermiSliSANA

  9. Image

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. |Endecaheme c-Type|Iltt: FermiSliSANANov, 1. 2011 1:

  10. Image

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to: navigation,Ohio:GreerHiCalifornia:ISI SolarIdanha,Information Illinois.Illumitex

  11. Search Log Analysis of the ARTstor Cultural Heritage Image Database

    E-Print Network [OSTI]

    Lowe, Heather Ann

    2013-01-01T23:59:59.000Z

    Image downloaded Advanced search Records when an image ispages Records when an advanced search function is used The

  12. Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres

    E-Print Network [OSTI]

    Berchane, Nader Samir

    2009-05-15T23:59:59.000Z

    The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

  13. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans

    SciTech Connect (OSTI)

    NONE

    2011-02-15T23:59:59.000Z

    Purpose: The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography (CT) scans. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI) completed such a database, establishing a publicly available reference for the medical imaging research community. Initiated by the National Cancer Institute (NCI), further advanced by the Foundation for the National Institutes of Health (FNIH), and accompanied by the Food and Drug Administration (FDA) through active participation, this public-private partnership demonstrates the success of a consortium founded on a consensus-based process. Methods: Seven academic centers and eight medical imaging companies collaborated to identify, address, and resolve challenging organizational, technical, and clinical issues to provide a solid foundation for a robust database. The LIDC/IDRI Database contains 1018 cases, each of which includes images from a clinical thoracic CT scan and an associated XML file that records the results of a two-phase image annotation process performed by four experienced thoracic radiologists. In the initial blinded-read phase, each radiologist independently reviewed each CT scan and marked lesions belonging to one of three categories (''nodule{>=}3 mm,''''nodule<3 mm,'' and ''non-nodule{>=}3 mm''). In the subsequent unblinded-read phase, each radiologist independently reviewed their own marks along with the anonymized marks of the three other radiologists to render a final opinion. The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus. Results: The Database contains 7371 lesions marked ''nodule'' by at least one radiologist. 2669 of these lesions were marked ''nodule{>=}3 mm'' by at least one radiologist, of which 928 (34.7%) received such marks from all four radiologists. These 2669 lesions include nodule outlines and subjective nodule characteristic ratings. Conclusions: The LIDC/IDRI Database is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.

  14. Relativistic approach to electromagnetic imaging

    E-Print Network [OSTI]

    Budko, N

    2004-01-01T23:59:59.000Z

    A novel imaging principle based on the interaction of electromagnetic waves with a beam of relativistic electrons is proposed. Wave-particle interaction is assumed to take place in a small spatial domain, so that each electron is only briefly accelerated by the incident field. In the one-dimensional case the spatial distribution of the source density can be directly observed in the temporal spectrum of the scattered field. Whereas, in the two-dimensional case the relation between the source and the spectrum is shown to be approximately the Radon transform.

  15. Relativistic approach to electromagnetic imaging

    E-Print Network [OSTI]

    Neil Budko

    2004-03-11T23:59:59.000Z

    A novel imaging principle based on the interaction of electromagnetic waves with a beam of relativistic electrons is proposed. Wave-particle interaction is assumed to take place in a small spatial domain, so that each electron is only briefly accelerated by the incident field. In the one-dimensional case the spatial distribution of the source density can be directly observed in the temporal spectrum of the scattered field. Whereas, in the two-dimensional case the relation between the source and the spectrum is shown to be approximately the Radon transform.

  16. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LawrenceE C H N ILensless Imaging of Magnetic

  17. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LawrenceE C H N ILensless Imaging of

  18. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LawrenceE C H N ILensless Imaging ofLensless

  19. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LawrenceE C H N ILensless Imaging

  20. Lensless Imaging of Magnetic Nanostructures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and Interfaces Sample6, 2011 LawrenceE C H N ILensless ImagingLensless