National Library of Energy BETA

Sample records for identify target audiences

  1. Audience Segmentation and Analysis Strategies for Targeted Marketing...

    Energy Savers [EERE]

    Audience Segmentation and Analysis Strategies for Targeted Marketing (101) Audience Segmentation and Analysis Strategies for Targeted Marketing (101) September 24, 2015 12:30PM to...

  2. FOOD 527G (3 credits) HACCP Food Safety Management System Target Audience

    E-Print Network [OSTI]

    1 FOOD 527G (3 credits) HACCP Food Safety Management System Target Audience The course is designed primarily for the MFS (Master of Food Science) students. However, this course would also be beneficial for other Food Science graduate students (M.Sc. and Ph.D.). Course Description The HACCP (Hazard Analysis

  3. Online Research Guides: Audience, Assessment, and Advice

    E-Print Network [OSTI]

    Giullian, Jon C.

    2013-05-23

    . Questions: How do we customize our research guides (LibGuides) in order to optimize them for each audience? Target audience ?undergraduate: enrolled in Russia/Slavic related courses • Expectations: KU student are expected to do research for short...(1), 53-63. • Reeb, B., & Gibbons, S. (2004). Students, librarians, and subject guides: Improving a poor rate of return. Portal?: Libraries and the Academy, 4(1), 123-130. • Roberts, S., & Hunter, D. (2011). New library, new librarian, new student...

  4. A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses 

    E-Print Network [OSTI]

    Conway, David J; Cavanagh, David R; Tanabe, K; Roper, C; Mikes, Z S; Sakihama, N; Bojang, K A; Oduola, A M J; Kremsner, P G; Arnot, D E; Greenwood, B M; McBride, J S

    New strategies are required to identify the most important targets of protective immunity in complex eukaryotic pathogens. Natural selection maintains allelic variation in some antigens of the malaria parasite Plasmodium ...

  5. Standoff Spectroscopy Using a Conditioned Target Identifies Hazardous Materials at a Distance

    Energy Innovation Portal (Marketing Summaries) [EERE]

    2012-09-26

    A safer method for the standoff (long distance) detection and identification ofmolecules on a surface has been invented by researchers at ORNL and the Universityof Tennessee. This invention avoids the necessity of close and potentially hazardouscontact. It combines tunable infrared (IR) and ultraviolet (UV) spectroscopy techniquesto target identifying properties of surface residues....

  6. Audience Categorization and Behavior Change

    Broader source: Energy.gov [DOE]

    This sheet from the U.S. Department of Energy Better Buildings Neighborhood Program is a tool to use for audience brainstorm and categorization, and assessing desired behavior change.

  7. Audience Design in Word Order 

    E-Print Network [OSTI]

    Melville, Margot

    2013-11-27

    When we speak, we adapt what we say according to our listeners. This ability is established at the levels of concepts and lexical choice, but it is less certain whether audience design is possible in grammatical structure. ...

  8. Omen: identifying potential spear-phishing targets before the email is sent.

    SciTech Connect (OSTI)

    Wendt, Jeremy Daniel

    2013-07-01

    We present the results of a two year project focused on a common social engineering attack method called %22spear phishing%22. In a spear phishing attack, the user receives an email with information specifically focused on the user. This email contains either a malware-laced attachment or a link to download the malware that has been disguised as a useful program. Spear phishing attacks have been one of the most effective avenues for attackers to gain initial entry into a target network. This project focused on a proactive approach to spear phishing. To create an effective, user-specific spear phishing email, the attacker must research the intended recipient. We believe that much of the information used by the attacker is provided by the target organization's own external website. Thus when researching potential targets, the attacker leaves signs of his research in the webserver's logs. We created tools and visualizations to improve cybersecurity analysts' abilities to quickly understand a visitor's visit patterns and interests. Given these suspicious visitors and log-parsing tools, analysts can more quickly identify truly suspicious visitors, search for potential spear-phishing targeted users, and improve security around those users before the spear phishing email is sent.

  9. Geothermal Target Areas in Colorado as Identified by Remote Sensing Techniques

    SciTech Connect (OSTI)

    Hussein, Khalid

    2012-02-01

    Citation Information: Originator: Earth Science &Observation Center (ESOC), CIRES, University of Colorado at Boulder Publication Date: 2012 Title: Target Areas Edition: First Publication Information: Publication Place: Earth Science & Observation Center, Cooperative Institute for Research in Environmental Science, University of Colorado, Boulder, Colorado Publisher: Earth Science &Observation Center (ESOC), CIRES, University of Colorado at Boulder Description: This layer contains the areas identified as targets of potential geothermal activity. The Criteria used to identify the target areas include: hot/warm surface exposures modeled from ASTER/Landsat satellite imagery and geological characteristics, alteration mineral commonly associated with hot springs (clays, Si, and FeOx) modeled from ASTER and Landsat data, Coloradodo Geological Survey (CGS) known thermal hot springs/wells and heat-flow data points, Colorado deep-seated fault zones, weakened basement identified from isostatic gravity data, and Colorado sedimentary and topographic characteristics Spatial Domain: Extent: Top: 4546251.530446 m Left: 151398.567298 m Right: 502919.587395 m Bottom: 4095100.068903 m Contact Information: Contact Organization: Earth Science &Observation Center (ESOC), CIRES, University of Colorado at Boulder Contact Person: Khalid Hussein Address: CIRES, Ekeley Building Earth Science & Observation Center (ESOC) 216 UCB City: Boulder State: CO Postal Code: 80309-0216 Country: USA Contact Telephone: 303-492-6782 Spatial Reference Information: Coordinate System: Universal Transverse Mercator (UTM) WGS’1984 Zone 13N False Easting: 500000.00000000 False Northing: 0.00000000 Central Meridian: -105.00000000 Scale Factor: 0.99960000 Latitude of Origin: 0.00000000 Linear Unit: Meter Datum: World Geodetic System ’1984 (WGS ’1984) Prime Meridian: Greenwich Angular Unit: Degree Digital Form: Format Name: Shape file

  10. Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor

    E-Print Network [OSTI]

    Gerstein, Mark

    Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor targets predicted by sequence-alignment databases and the relative low accuracy of such predictions which with tumor progression in squamous cell carcinoma of the head and neck (HNSCC). We further demonstrate

  11. Intimate Encounters: the Mixed Reality Paradigm and Audience Responses

    E-Print Network [OSTI]

    Cleland, Kathy

    2009-01-01

    and artificial characters. Images that move on a screen (especially in the audience’s peripheral vision)

  12. Audience design: embedded versus word search priming 

    E-Print Network [OSTI]

    Leckie, Tomlin

    2010-06-28

    The present study looks at manipulating audience design using different priming techniques. We were trying to test the effectiveness of different priming techniques (priming words embedded in a story versus priming words embedded in a word search...

  13. Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers

    SciTech Connect (OSTI)

    Cho, Nancy L., E-mail: nlcho@partners.org [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Lin, Chi-Iou [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Du, Jinyan [Broad Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 (United States)] [Broad Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 (United States); Whang, Edward E. [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States); Ito, Hiromichi [Department of Surgery, Michigan State University, Lansing, MI 48912 (United States)] [Department of Surgery, Michigan State University, Lansing, MI 48912 (United States); Moore, Francis D.; Ruan, Daniel T. [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)] [Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115 (United States)

    2012-05-11

    Highlights: Black-Right-Pointing-Pointer Kinome profiling is a novel technique for identifying activated kinases in human cancers. Black-Right-Pointing-Pointer Src activity is increased in invasive thyroid cancers. Black-Right-Pointing-Pointer Inhibition of Src activity decreased proliferation and invasion in vitro. Black-Right-Pointing-Pointer Further investigation of Src targeted therapies in thyroid cancer is warranted. -- Abstract: Background: Novel therapies are needed for the treatment of invasive thyroid cancers. Aberrant activation of tyrosine kinases plays an important role in thyroid oncogenesis. Because current targeted therapies are biased toward a small subset of tyrosine kinases, we conducted a study to reveal novel therapeutic targets for thyroid cancer using a bead-based, high-throughput system. Methods: Thyroid tumors and matched normal tissues were harvested from twenty-six patients in the operating room. Protein lysates were analyzed using the Luminex immunosandwich, a bead-based kinase phosphorylation assay. Data was analyzed using GenePattern 3.0 software and clustered according to histology, demographic factors, and tumor status regarding capsular invasion, size, lymphovascular invasion, and extrathyroidal extension. Survival and invasion assays were performed to determine the effect of Src inhibition in papillary thyroid cancer (PTC) cells. Results: Tyrosine kinome profiling demonstrated upregulation of nine tyrosine kinases in tumors relative to matched normal thyroid tissue: EGFR, PTK6, BTK, HCK, ABL1, TNK1, GRB2, ERK, and SRC. Supervised clustering of well-differentiated tumors by histology, gender, age, or size did not reveal significant differences in tyrosine kinase activity. However, supervised clustering by the presence of invasive disease showed increased Src activity in invasive tumors relative to non-invasive tumors (60% v. 0%, p < 0.05). In vitro, we found that Src inhibition in PTC cells decreased cell invasion and proliferation. Conclusion: Global kinome analysis enables the discovery of novel targets for thyroid cancer therapy. Further investigation of Src targeted therapy for advanced thyroid cancer is warranted.

  14. Comprehensive metabolomic, lipidomic and microscopic profiling of Yarrowia lipolytica during lipid accumulation identifies targets for increased lipogenesis

    SciTech Connect (OSTI)

    Pomraning, Kyle R.; Wei, Siwei; Karagiosis, Sue A.; Kim, Young-Mo; Dohnalkova, Alice; Arey, Bruce W.; Bredeweg, Erin L.; Orr, Galya; Metz, Thomas O.; Baker, Scott E.

    2015-04-23

    Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the key biological processes involved. We applied a combination of metabolomic and lipidomic profiling approaches as well as microscopic techniques to identify and characterize the key pathways involved in de novo lipid accumulation from glucose in batch cultured, wild-type Y. lipolytica. We found that lipids accumulated rapidly and peaked at 48 hours during the five day experiment, concurrent with a shift in amino acid metabolism. We also report that Y. lipolytica secretes disaccharides early in batch culture and reabsorbs them when extracellular glucose is depleted. Exhaustion of extracellular sugars coincided with thickening of the cell wall, suggesting that genes involved in cell wall biogenesis may be a useful target for improving the efficiency of lipid producing yeast strains.

  15. Audience research for fun and profit : rediscovering the value of television audiences

    E-Print Network [OSTI]

    Seles, Sheila Murphy

    2010-01-01

    The American television industry is in a moment of transition because of changes brought about by digital distribution and audience fragmentation. This thesis argues that the television industry can no longer adapt to the ...

  16. Audience Segmentation and Analysis Strategies for Targeted Marketing (301)

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De p u tCorporationIt'sDOE Phasedare listedwill beAdvisory|

  17. Audience Segmentation and Analysis Strategies for Targeted Marketing (301)

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De p u tCorporationIt'sDOE Phasedare listedwill beAdvisory||

  18. Creators, Audiences, and New Media: Creativity in an Interactive Environment

    E-Print Network [OSTI]

    Bell, Isaac William

    2014-08-31

    Composition and media scholars have in the past examined the participants and steps in the creative process as distinct roles and actions, with a separation between creators and audiences, including gatekeeping audiences ...

  19. Prior experience and its effects on audience design 

    E-Print Network [OSTI]

    Wilson, Kerry

    2008-06-27

    PRIOR EXPERIENCE AND ITS EFFECTS ON AUDIENCE DESIGN. Abstract Objective Audience design involves tailoring utterances to suit the needs of your partner. The current experiment was interested in whether a speaker’s ...

  20. Spring Flicks 2008 Winners Audience Award, Winner: THIN WALLS

    E-Print Network [OSTI]

    Hemmers, Oliver

    Spring Flicks 2008 Winners Audience Award, Winner: THIN WALLS Audience Award, First Runner-Up: HIStory Audience Award Second Runner-up: PASSENGER SEAT Jury Award, Best Short Winner: PASSENGER SEAT Jury Award, Best Director, Winner: Jerry and Mike Thompson, PASSENGER SEAT Jury Award, Best Director, First

  1. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired Solar Fuel ProductionRecoverable User Guide Nuclear ScienceTargets

  2. Communicative Implications of the Modern Video Game: An Audience-Centered Approach

    E-Print Network [OSTI]

    Richards, Kyle Dudley

    2010-12-31

    of playing video games, then identifies a lack of focus in the literature on the communicative aspect of audience-centered analysis of these games via gamer-generated blogs and message board interactions. Subsequently, a rhetorical analysis of two independent...

  3. In Search of the Audience - Forty Years of German Public Television and Its Audience Driven Commercialization

    E-Print Network [OSTI]

    Goebel, Baerbel

    2011-04-11

    . It is an honor for me to thank my friends Anja Frey and Sanja Ludwig who have helped me to overcome technical difficulties and have been extraordinary in their efforts to collate data for me. Silvia Prickler deserves a special acknowledgment for making the access...………………………………………………………39 A Love-to-See-Evil Relationship………………………………………………...42 Curtain Call for Reality…………………………………………………………..46 For Crying out Loud – The Democratic Audience………………………………53 The Poison Locker……………………………………………………………….57 Chapter 2: Let the Battle Begin...

  4. Enhancing Graduate Student Communication to General Audiences through Blogging about Nanotechnology and Sustainability

    SciTech Connect (OSTI)

    Bishop, Lee M.; Tillman, Ayesha S.; Geiger, Franz M.; Haynes, Christy L.; Klaper, Rebecca D.; Murphy, Catherine; Orr, Galya; Pedersen, Joel A.; DeStefano, Lizanne; Hamers, Robert J.

    2014-10-14

    We have developed and assessed a multiauthor science blog on the topic of nanotechnology and sustainability as a tool to improve the written communication and public engagement skills of graduate students. Focus group studies revealed that after participation in the blog, student authors felt more confident and capable of communicating technical topics to general audiences. Students' research mentors viewed this as an important component of their students' education, as indicated by survey data. Important design aspects of this effort include participation of an editor as well as having flexible content and target-audience guidelines. We have explicitly outlined aspects of the effort we see as critical in order to enable others to replicate this model in related settings.

  5. Domestic Audiences, Policy Feedback, and Sequential Decisions During Military Interventions 

    E-Print Network [OSTI]

    Kuberski, Douglas Walter

    2011-02-22

    The literature on escalation situations and audience costs suggests that democratic executives tend to increase commitment to a foreign policy in response to negative feedback. However, real-world cases from international ...

  6. Targeting in Advertising Markets: Implications for Offline Versus Online Media

    E-Print Network [OSTI]

    Bergemann, Dirk

    We develop a model with many advertisers (products) and many advertising markets (media). Each advertiser sells to a different segment of consumers, and each medium is targeting a different audience. We characterize the ...

  7. Keeping Up With Your Audience, So They Keep Up with Your Program

    Broader source: Energy.gov [DOE]

    Keeping Up With Your Audience, So They Keep Up with Your Program - BBNP Program Implementation - Snapshot Series Webinar, May 17, 2012

  8. User Guide Submitting a Proposal in RMS 2.0 Target Audience Applicants

    E-Print Network [OSTI]

    Mucina, Ladislav

    .....................................................................11 PART 3 ­ Filling out the proposal form..........................................................12.9 ­ Submitting a proposal to your Research Office .................................20 3.10 ­ Reviving a deleted with different browsers or older versions of Google Chrome and Microsoft Internet Explorer is not guaranteed. RMS

  9. A Feminist Dialogue on Theatre for Young Audiences through Suzan Zeder's Plays.

    E-Print Network [OSTI]

    Klein, Jeanne; Austin, Gayle; Zeder, Suzan; Still, James; Smith, Iris

    1997-01-01

    Klein and Austin share perceptions of Theatre for Young Audiences and discuss three plays by Suzan Zeder using feminist dramatic criticism. Zeder responded from her playwright's perspective. Subsequently, playwright James ...

  10. "I, uh, meant to do that!" - Intentional Disfluency as an Element of Audience Design 

    E-Print Network [OSTI]

    Stephen, Julie Anne

    2010-06-30

    planning (Blackmer & Mitton, 1991; Postma & Kolk, 1993). Codability of items was introduced as a factor to increase rates of overall disfluency. It was also of interest to establish whether disfluency rates would pattern with intentional audience design...

  11. Reciprocity in Language: Evidence for the effect of reciprocal relationships on the use of audience design. 

    E-Print Network [OSTI]

    Wardrope, Jillian A.

    2008-06-27

    described as the ‘chameleon effect’ (Chartrand & Bargh, 1999), or our linguistic behaviour, through a priming effect involving others’ linguistic choices (Branigan, Pickering & Cleland, 2000a). Through a process known as audience design (Bell, 2001), we can...

  12. Investigating the effect of empathy on word order in audience design 

    E-Print Network [OSTI]

    Marcar, Genevieve

    2006-01-01

    Exploration into the field of empathy has indicated its association with helpful behaviour. In doing so it has brought to attention the possibility that empathy may be associated with the practice of audience design (i.e. ...

  13. A Study to investigate whether empathic state affects audience design through word order 

    E-Print Network [OSTI]

    Langley, Caroline

    2006-01-01

    The present study set out to investigate whether an association existed between individuals’ state of empathy and engagement in audience design, whereby speakers tailor their utterances for the benefit of their addressees ...

  14. Semantic Analysis of Web Site Audience Jean-Pierre Norguet

    E-Print Network [OSTI]

    Libre de Bruxelles, Université

    , most reports target Web designers and Web devel- opers [15]. Summary reports like the number With the emergence of the World Wide Web, analyzing and improving Web communication has become essential to adapt Server OLAP Analysis Service and our prototype WASA for a number of case studies. Finally, we validate

  15. 718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history

    E-Print Network [OSTI]

    Fitelson, Branden

    718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history covered, in the level of detail, and in the degree to which rival scholarly interpretations are actively). Of course, every book must treat some things more painstakingly than others. But scholars, at any rate

  16. Semantic Analysis of Web Site Audience by Integrating Web Usage Mining and Web

    E-Print Network [OSTI]

    Libre de Bruxelles, Université

    Semantic Analysis of Web Site Audience by Integrating Web Usage Mining and Web Content Mining Jean://www.jrc.it/langtech Abstract. With the emergence of the World Wide Web, analyzing and improving Web communication has become essential to adapt the Web content to the visitors' expectations. Web communication analysis

  17. Quantifying the Invisible Audience in Social Networks Michael S. Bernstein1,2

    E-Print Network [OSTI]

    Pratt, Vaughan

    to examine how well users' perceptions of their audi- ence match their actual audience on Facebook. We find , Moira Burke2 , Brian Karrer2 Stanford University HCI Group1 Facebook Data Science2 Computer Science content in an online social network, who is listening? Users have scarce information about who actually

  18. Identifying Activity

    E-Print Network [OSTI]

    Lewis, Adrian S

    2009-01-01

    Identification of active constraints in constrained optimization is of interest from both practical and theoretical viewpoints, as it holds the promise of reducing an inequality-constrained problem to an equality-constrained problem, in a neighborhood of a solution. We study this issue in the more general setting of composite nonsmooth minimization, in which the objective is a composition of a smooth vector function c with a lower semicontinuous function h, typically nonsmooth but structured. In this setting, the graph of the generalized gradient of h can often be decomposed into a union (nondisjoint) of simpler subsets. "Identification" amounts to deciding which subsets of the graph are "active" in the criticality conditions at a given solution. We give conditions under which any convergent sequence of approximate critical points finitely identifies the activity. Prominent among these properties is a condition akin to the Mangasarian-Fromovitz constraint qualification, which ensures boundedness of the set of...

  19. Prior Experience and Personality’s Impact on the Practice of Audience Design and its Ability to Transfer to a Novel Task. 

    E-Print Network [OSTI]

    Paterson, Claire

    2008-01-01

    Bell (1991) argued that utterances are designed primarily with their audience in mind. Audience design, tailoring an utterance to accommodate an addressee’s needs, is only successful if the speaker possesses an accurate ...

  20. Audience design in children’s referential descriptions of abstract and concrete stimuli as a function of addressee familiarity: The boundaries of success. 

    E-Print Network [OSTI]

    Peel, Anna

    Audience design facilitates understanding by ensuring utterances are tailored to addressee needs (Clark & Murphy, 1982). The present research studied audience design in the length, hedging and article use of children’s references to abstract...

  1. Audience Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram:Y-12Power, Inc | DepartmentPeer ReviewEfficiencyOct 1, 2011 - Sep 21,

  2. Audience Design in Children: Evidence of listener-specific conceptual reference at 6-7 years old 

    E-Print Network [OSTI]

    Reid Milligan, Simon D.

    Speakers tend to design their utterances specifically for respective audiences (AD). The knowledge that a referential concept is shared with a particular listener allows the speaker to make, otherwise ambiguous, abbreviated and definite reference...

  3. It’s like priming: An Investigation into the Priming and Audience effects for the Discourse Marker like. 

    E-Print Network [OSTI]

    McLeod, Andrew

    2007-01-01

    Research into priming has shown that it is possible to prime both words and syntactic structure in speech. Similarly, investigations into audience design and alignment have shown that language use and speech in general ...

  4. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M. (Brookline, MA); Janse, Daniel M. (Brookline, MA)

    2008-05-13

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  5. Standoff Spectroscopy Using a Conditioned Target Identifies Hazardous

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3 SpecialSponsorJurczynski andMicrowave

  6. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A. (Falls Church, VA)

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  7. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  8. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  9. Target Chamber

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S. Coal StocksSuppliers Tag:TakeSeptember 13,TaraTarget Chamber

  10. ‘But it’s Just a Joke!’: Latino Audiences’ Primed Reactions to Latino Comedians and their Use of Race-Based Humor 

    E-Print Network [OSTI]

    Martinez, Amanda

    2012-02-14

    Racism persists individually and institutionally in the U.S. and race-based comedy prevails in media, accepted by diverse audiences as jokes. Media priming and Social Identity Theory theoretically ground this two-part ...

  11. Category-Based Audience Metrics for Web Site Content Improvement using Ontologies and

    E-Print Network [OSTI]

    Libre de Bruxelles, Université

    target Web designers and Web developers [15]. Summary reports like the number of visitors and the number e-mail: {btshibas,gbonte}@ulb.ac.be Abstract. With the emergence of the World Wide Web, analyzing the versions of the pages using automatic classifiers. 1 Motivations and Related Work With the emergence

  12. Personally Identifiable Information

    Broader source: Energy.gov [DOE]

    Websites and applications that collect data on individuals are gathering personally identifiable information (PII). PII is also often collected for customer surveys or user experience (UX) research.

  13. The Color Lavender: Audience Reception, Adaptation, and Performance of The Color Purple 

    E-Print Network [OSTI]

    Melton, Elizabeth M.

    2010-07-14

    ......................................................................... 18 Cinematic transformation .............................................................. 23 Musical adaptations ....................................................................... 29 IV PERFORMANCE... Celie?s story, but he also identified a, ?sumptuousness throughout that? does 16 bring to mind the enjoyably hokey cinematic ravishments of Steven Spielberg?s 1985 film version.? Jeremy McCarter, too, felt the musical was a predictable, soft...

  14. ThermoMechanical Analysis of ISIS TS2 Spallation Target

    E-Print Network [OSTI]

    McDonald, Kirk

    1 ThermoMechanical Analysis of ISIS TS2 Spallation Target Dan Wilcox High Power Targets Group, Rutherford Appleton Laboratory 5th High Power Targetry Workshop, Fermilab 21/05/2014 #12;ISIS Overview Target at 50Hz #12;Background · Aim: model the operating condition of the current ISIS TS2 target ­ Identify

  15. Metal alloy identifier

    DOE Patents [OSTI]

    Riley, William D. (Avondale, MD); Brown, Jr., Robert D. (Avondale, MD)

    1987-01-01

    To identify the composition of a metal alloy, sparks generated from the alloy are optically observed and spectrographically analyzed. The spectrographic data, in the form of a full-spectrum plot of intensity versus wavelength, provide the "signature" of the metal alloy. This signature can be compared with similar plots for alloys of known composition to establish the unknown composition by a positive match with a known alloy. An alternative method is to form intensity ratios for pairs of predetermined wavelengths within the observed spectrum and to then compare the values of such ratios with similar values for known alloy compositions, thereby to positively identify the unknown alloy composition.

  16. Table Set-up with Materials Target Audience: Parents of elementary school students (grades 3-6) and Middle and High School Students

    E-Print Network [OSTI]

    Linhardt, Robert J.

    students. BOM: LED (Light Emitting Diode), breadboard, resistor, Wires, 9V battery, Potentiometer to manage

  17. Identifying Classified Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-10-03

    To establish the program to identify information classified under the Atomic Energy Act [Restricted Data (RD), Formerly Restricted Data (FRD), and Transclassified Foreign Nuclear Information (TFNI)] or Executive Order (E.O.) 13526 [National Security Information (NSI)], so that it can be protected against unauthorized dissemination. Supersedes DOE O 475.2A.

  18. Identifying Classified Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-06-03

    The Order establishes the program to identify information classified under the Atomic Energy Act [Restricted Data (RD), Formerly Restricted Data (FRD), and Transclassified Foreign Nuclear Information (TFNI)]or Executive Order (E.O.) 13526 [National Security Information (NSI)], so that it can be protected against unauthorized dissemination.

  19. Identifying Classified Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-02-01

    The Order establishes the program to identify information classified under the Atomic Energy Act [Restricted Data (RD), Formerly Restricted Data (FRD), and Transclassified Foreign Nuclear Information (TFNI)] or Executive Order (E.O.) 13526 [National Security Information (NSI)], so that it can be protected against unauthorized dissemination. Cancels DOE O 475.2 and DOE M 475.1-1B.

  20. Identifying Classified Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-08-28

    The Order establishes the program to identify information classified under the Atomic Energy Act [Restricted Data (RD) and Formerly Restricted Data (FRD)] or Executive Order 12958, as amended [National Security Information (NSI)], so that it can be protected against unauthorized dissemination. Canceled by DOE O 475.2

  1. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept V. Graves Target Studies EVO April 11, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 11 Apr 2012 Target Vessel;3 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 11 Apr 2012 Starting Point

  2. Microfluidic in vivo screen identifies compounds enhancing neuronal

    E-Print Network [OSTI]

    Haggarty, Stephen J.

    Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens ...

  3. Audience/Panel Discussion: Sites Lesson Learned about Activity-level Work Planning and Control Using EFCOG Work Planning and Control Guideline

    Broader source: Energy.gov [DOE]

    Slide Presentation by Donna J. Governor, Deputy Dept Mgr for Planning & Integration, Lawrence Livermore National Laboratory. Lawrence Livermore National Laboratory work planning and control lessons learned and audience/panel discussion on site's lessons learned about Activity-level Work Planning and Control using EFCOG Work Planning and Control Guideline Document.

  4. Tracking target objects orbiting earth using satellite-based telescopes

    DOE Patents [OSTI]

    De Vries, Willem H; Olivier, Scot S; Pertica, Alexander J

    2014-10-14

    A system for tracking objects that are in earth orbit via a constellation or network of satellites having imaging devices is provided. An object tracking system includes a ground controller and, for each satellite in the constellation, an onboard controller. The ground controller receives ephemeris information for a target object and directs that ephemeris information be transmitted to the satellites. Each onboard controller receives ephemeris information for a target object, collects images of the target object based on the expected location of the target object at an expected time, identifies actual locations of the target object from the collected images, and identifies a next expected location at a next expected time based on the identified actual locations of the target object. The onboard controller processes the collected image to identify the actual location of the target object and transmits the actual location information to the ground controller.

  5. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept Update V. Graves T. Lessard Target Studies EVO June 26, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 of Energy Target Vessel Update 26 June 2012 Review - Mercury Module Extraction #12;4 Managed by UT

  6. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept Update V. Graves Target Studies EVO June 12, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 12 June 2012 Review ­ IPAC #12;3 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 12 June 2012 Inner

  7. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concepts Updated 4/16/12 V. Graves Target Studies EVO April 11, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 16 Apr 2012 Target Vessel Requirements · Accurate jet placement · Jet/beam dump pool · Double containment of mercury

  8. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    Neutrino Factory Target Vessel Concept V. Graves Target Studies EVO May 1, 2012 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Concept 1 May 2012 Review ­ Two Target Vessel Ideas · Solid-Battelle for the U.S. Department of Energy Target Vessel Concept 1 May 2012 #12;4 Managed by UT-Battelle for the U

  9. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  10. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K. (Livermore, CA); Hunt, Angus L. (Alamo, CA)

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  11. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  12. First SNS Target Replacement

    E-Print Network [OSTI]

    McDonald, Kirk

    ) used to drain the mercury to a shielded storage tank is the only active element. · However, the process · A shielded "Target Service Bay" located downstream of the target-proton beam interaction monolith serves

  13. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  14. Ultra-low field nuclear magnetic resonance and magnetic resonance imaging to discriminate and identify materials

    DOE Patents [OSTI]

    Kraus, Robert H. (Los Alamos, NM); Matlashov, Andrei N. (Los Alamos, NM); Espy, Michelle A. (Los Alamos, NM); Volegov, Petr L. (Los Alamos, NM)

    2010-03-30

    An ultra-low magnetic field NMR system can non-invasively examine containers. Database matching techniques can then identify hazardous materials within the containers. Ultra-low field NMR systems are ideal for this purpose because they do not require large powerful magnets and because they can examine materials enclosed in conductive shells such as lead shells. The NMR examination technique can be combined with ultra-low field NMR imaging, where an NMR image is obtained and analyzed to identify target volumes. Spatial sensitivity encoding can also be used to identify target volumes. After the target volumes are identified the NMR measurement technique can be used to identify their contents.

  15. ESO Imaging Survey: Finding Targets for VLT

    E-Print Network [OSTI]

    L. N. da Costa

    1998-09-16

    Data from the wide-angle, moderately deep ESO Imaging Survey have been used to produce target lists for the first year of the VLT. About 250 candidate clusters of galaxies have been identified from the I-band images covering $\\sim$ 17 square degrees. In addition, using the multicolor data available over an area of 1.3 square degrees over 300 potentially interesting point-sources have been selected. The color-selected targets include low-mass stars/brown dwarfs, white-dwarfs and quasars. Images, object catalogs and derived target lists are available from the world-wide web (http://www.eso.org/eis)

  16. Eigenbehaviors: Identifying Structure in Routine

    E-Print Network [OSTI]

    Pentland, Alex Paul

    Longitudinal behavioral data generally contains a significant amount of structure. In this work, we identify the structure inherent in daily behavior with models that can accurately analyze, predict, and cluster multimodal ...

  17. Manual for Identifying Classified Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-08-28

    The Manual provides detailed requirements to supplement DOE O 475.2, Identifying Classified Information, dated 8/28/07. Cancels DOE M 475.1-1A; canceled by DOE O 475.2A

  18. 100-B/C Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    R.W. Ovink

    2010-03-18

    This report documents the process used to identify source area target analytes in support of the 100-B/C remedial investigation/feasibility study addendum to DOE/RL-2008-46. This report also establishes the analyte exclusion criteria applicable for 100-B/C use and the analytical methods needed to analyze the target analytes.

  19. Accounting for population variation in targeted proteomics

    SciTech Connect (OSTI)

    Fujimoto, Grant M.; Monroe, Matthew E.; Rodriguez, Larissa M.; Wu, Chaochao; MacLean, Brendan; Smith, Richard D.; MacCoss, Michael; Payne, Samuel H.

    2014-01-03

    Individual proteomes typically differ from the reference human proteome at ~10,000 single amino acid variants. When viewed at the population scale, this individual variation results in a wide variety of protein sequences. In targeted proteomics experiments, such variability would confound accurate protein quantification. To facilitate researchers in identifying target peptides with high variability within the human population we have created the Population Variation plug-in for Skyline, which provides easy access to the polymorphisms stored in dbSNP. Given a set of peptides, the tool reports minor allele frequency for common polymorphisms. We highlight the importance of considering genetic variation by applying the tool to public datasets.

  20. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  1. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  2. Environmental management system objectives & targets results summary :

    SciTech Connect (OSTI)

    Vetter, Douglas Walter

    2014-04-01

    Sandia National Laboratories/New Mexicos (SNL/NM) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each Fiscal Year (FY) SNL/NM performs an analysis to identify environmental aspects, and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are established to mitigate potential impacts of SNL/NMs operations on the environment. An annual summary of the results achieved towards meeting established Sandia Corporation and SNL/NM Site-specific objectives and targets provides a connection to, and rational for, annually revised environmental aspects. The purpose of this document is to summarize the results achieved and documented in FY2013.

  3. Solvent recovery targeting

    SciTech Connect (OSTI)

    Ahmad, B.S.; Barton, P.I.

    1999-02-01

    One of the environmental challenges faced by the pharmaceutical and specialty chemical industries is the widespread use of organic solvents. With a solvent-based chemistry, the solvent necessarily has to be separated from the product. Chemical species in waste-solvent streams typically form multicomponent azeotropic mixtures, and this often complicates separation and, hence, recovery of solvents. A design approach is presented whereby process modifications proposed by the engineer to reduce the formation of waste-solvent streams can be evaluated systematically. This approach, called solvent recovery targeting, exploits a recently developed algorithm for elucidating the separation alternatives achievable when applying batch distillation to homogeneous multicomponent mixtures. The approach places the composition of the waste-solvent mixture correctly in the relevant residue curve map and computes the maximum amount of pure material that can be recovered via batch distillation. Solvent recovery targeting is applied to two case studies derived from real industrial processes.

  4. Protecting FWP Participant Personally Identifiable Information...

    Energy Savers [EERE]

    Protecting FWP Participant Personally Identifiable InformationProtected Health Information Protecting FWP Participant Personally Identifiable InformationProtected Health...

  5. Target | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing CapacityVectren)ModelTalbotts Ltd JumpJumpInformationTaosTarget

  6. Apparatus for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L. (Livermore, CA)

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  7. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    Institute of Oncology of Asturias (IUOPA), HUCA, Universidada del Principado de Asturias (IUOPA), HUCA, Universidad de

  8. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

    E-Print Network [OSTI]

    Farhat, Maha R.

    M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely ...

  9. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    PLoS One 2009; 2: e895. Song CX, Szulwach KE, Fu Y, Dai Q,Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, et al. 5-hmC-cells), cerebral cortex (CX, CA1, CA3 and den- tate gyrus)

  10. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease

    E-Print Network [OSTI]

    2013-01-01

    putamen, substantia nigra, hypothalamus, globus pallidus andÀ 0.90 to À 0.95), hypothalamus ( À 0.82), globus pallidus (

  11. Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease

    E-Print Network [OSTI]

    Habib, Lila K.

    2011-01-01

    mixed with 5% potassium ferrocyanide and incubated at roomfor 15 minutes. Potassium ferrocyanide reacts with ferriciron to form ferric ferrocyanide, a blue colloidal complex

  12. Targeting the brain : identifying and inhibiting harmful protein-amyloid interactions in Alzheimer's disease

    E-Print Network [OSTI]

    Habib, Lila K.

    2011-01-01

    for enhanced delivery of quinine dihydrochloride to theand anti- malarial medications (quinine dihydrochloride and

  13. Behavior Wedge Profiles for Cities: A New Tool for Identifying Opportunities and Targeting Behavioral Programs

    E-Print Network [OSTI]

    Ehrhardt-Martinez, Karen

    2013-01-01

    on our list was plug-load management which represented the4 Plug load: Plug Load management 5 Heating & Cooling:Electronics: vampire load management with smart strips, plug

  14. Are domestic load profiles stable over time? An attempt to identify target households for demand

    E-Print Network [OSTI]

    ¨urich, Switzerland Email: beckel@inf.ethz.ch Thorsten Staake Energy Efficient Systems University of Bamberg 96047 Bamberg, Germany Email: thorsten.staake@uni-bamberg.de Abstract--Elaborating demand side management that the whole clustering of the time series, with a few adaptations on the usage of the K-Means algorithm

  15. Identifying Alternative Frames and Values to Increase Public Support for Health Policies that Target Obesity

    E-Print Network [OSTI]

    Ortiz, Selena E.

    2013-01-01

    from consuming genetically modified foods, foods that arelobbying, genetically modified foods, high-fructose cornlobbying, genetically modified foods, high-fructose corn

  16. Behavior Wedge Profiles for Cities: A New Tool for Identifying Opportunities and Targeting Behavioral Programs

    E-Print Network [OSTI]

    Ehrhardt-Martinez, Karen

    2013-01-01

    Defense Council and the Garrison Institute. 2010. “Simplefor the Urban Sustainability Directors Network. Garrison,NY: Garrison Institute. [EIA] Energy Information

  17. Identifying Alternative Frames and Values to Increase Public Support for Health Policies that Target Obesity

    E-Print Network [OSTI]

    Ortiz, Selena E.

    2013-01-01

    51 4.3. Alternative Frame No.2: The Manipulation206 8.2. Alternative Frames and ValuesReframing Obesity through Alternative Frames and Values 4.1.

  18. Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

    E-Print Network [OSTI]

    van den Boomen, D. J. H.; Lehner, P. J.

    2015-07-22

    components such as ERP. The substrate is then ubiquitinated by the ERAD d dislocated into the cytosol with the cytosolic AAA /VCP supplying the energy required for dislocation and extraction. p97 is recruited to the ERAD machinery by components including...

  19. Behavior Wedge Profiles for Cities: A New Tool for Identifying Opportunities and Targeting Behavioral Programs

    E-Print Network [OSTI]

    Ehrhardt-Martinez, Karen

    2013-01-01

    shifts and reductions in food waste, and 16 percent from2 days per week Beh. Reduce food waste by 25% Beh. Take one

  20. 1.Request is identified based on target address as being a VLS access

    E-Print Network [OSTI]

    California at Berkeley, University of

    -to-VLS data streaming via DMA engines BENCHMARKS Hand-tuned versions of several kernels designed to run rewritten. Provides benefits of C, but is lightweight and dynamically reconfigurable. Programmers have power is indexed in the on-chip memory hierarchy. SW-MANAGED LOCAL STORES Expose locality to software, requiring

  1. Behavior Wedge Profiles for Cities: A New Tool for Identifying Opportunities and Targeting Behavioral Programs

    E-Print Network [OSTI]

    Ehrhardt-Martinez, Karen

    2013-01-01

    households that don’t have dishwashers are not eligible toreduced use or changes in dishwasher settings. Similarly,in technology saturation such as dishwashers and central AC.

  2. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL -

  3. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - -

  4. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - -

  5. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServices »First ObservationFast(ER1) TargetRL - - -

  6. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you not find whatGasEnergyfeature photoTheory05 Target 1 Flight Path90L2

  7. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  8. National Renewable Energy Laboratory Report Identifies Research...

    Energy Savers [EERE]

    National Renewable Energy Laboratory Report Identifies Research Needed to Address Power Market Design Challenges National Renewable Energy Laboratory Report Identifies Research...

  9. Collecting Personally Identifiable Information Through the Web...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Requirements Collecting Personally Identifiable Information Through the Web and User Research Collecting Personally Identifiable Information Through the Web and User...

  10. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L. (Albuquerque, NM); Brusseau, Charles A. (Tijeras, NM)

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  11. PDFs for nuclear targets

    E-Print Network [OSTI]

    Karol Kovarik

    2010-06-25

    Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

  12. Identifying Renewable Energy Projects for Federal Agencies |...

    Broader source: Energy.gov (indexed) [DOE]

    projects that can help federal agencies meet their 30% renewable electricity by 2025 target. This research is summarized on this page. Renewable Energy Markets The size of the...

  13. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  14. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  15. Analysis ? Targeting Zero Net Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis - Targeting Zero Net Energy 2014 Building Technologies Office Peer Review Scott Horowitz, scott.horowitz@nrel.gov NREL Project Summary Timeline: Start date: 2010 Planned...

  16. Targeted online advertising : persuasion in an era of massless communication

    E-Print Network [OSTI]

    Baird, Eleanor Coumont

    2008-01-01

    In recent years, the decline of the mass media and the growth of a participatory and fragmented audience online have forced advertisers, agencies, and publishers to revise their thinking about delivering marketing messages ...

  17. Target R & D LBNE Collaboration Meeting

    E-Print Network [OSTI]

    McDonald, Kirk

    are not planning on having an integrated target / horn 1 · Will of course change if appropriate · The R&D effort Hall utilities) David Hickson (Target Hall utilities) Pat Hurh (Target technical components Tariq (Target pile, remote handling) Karl Williams (Target Hall utilities) Tim Wyman (Target Hall

  18. Targeted Specular Photons Michelle Laprade

    E-Print Network [OSTI]

    Montréal, Université de

    Targeted Specular Photons Michelle Laprade Département d'Informatique et de Recherche in the resulting image which are not captured using traditional photon map- ping algorithms. This method uses a separate group of photons ­ targeted specular photons ­ which are shot specifically towards

  19. Identify key design elements of desired function

    E-Print Network [OSTI]

    Nawroth, Janna C.

    DESIGN Identify key design elements of desired function Identify functionally equivalent implementation of key design elements (e.g. structure, physiology, kinematics etc.) Quantify functional and standardize fabrication for repeatability . Test phase: Quantify implementation of key design elements

  20. Identifying and Protecting Official Use Only Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-09

    To establish a program within the Department of Energy (DOE), including the National Nuclear Security Administration (NNSA), to identify certain unclassified controlled information as Official Use Only (OUO) and to identify, mark, and protect documents containing such information.

  1. Energy Assessment Results: Most Commonly Identified Recommendations...

    Office of Environmental Management (EM)

    Energy Assessment Results: Most Commonly Identified Recommendations The Missouri Industrial Assessment Center shares its experience providing energy assessments to local...

  2. Method of identifying plant pathogen tolerance

    DOE Patents [OSTI]

    Ecker, Joseph R. (Erial, NJ); Staskawicz, Brian J. (Castro Valley, CA); Bent, Andrew F. (Piedmont, CA); Innes, Roger W. (Bloomington, IN)

    1997-10-07

    A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a disease tolerant plant, is described. Plants identified by the foregoing process are also described.

  3. Method of identifying plant pathogen tolerance

    DOE Patents [OSTI]

    Ecker, J.R.; Staskawicz, B.J.; Bent, A.F.; Innes, R.W.

    1997-10-07

    A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a disease tolerant plant, is described. Plants identified by the foregoing process are also described. 7 figs.

  4. 100-K Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-K Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  5. 100-F Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-F Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  6. Identifying Fracture Types and Relative Ages Using Fluid Inclusion Stratigraphy

    SciTech Connect (OSTI)

    Dilley, Lorie M.; Norman, David; Owens, Lara

    2008-06-30

    Enhanced Geothermal Systems (EGS) are designed to recover heat from the subsurface by mechanically creating fractures in subsurface rocks. Understanding the life cycle of a fracture in a geothermal system is fundamental to the development of techniques for creating fractures. Recognizing the stage of a fracture, whether it is currently open and transmitting fluids; if it recently has closed; or if it is an ancient fracture would assist in targeting areas for further fracture stimulation. Identifying dense fracture areas as well as large open fractures from small fracture systems will also assist in fracture stimulation selection. Geothermal systems are constantly generating fractures, and fluids and gases passing through rocks in these systems leave small fluid and gas samples trapped in healed microfractures. Fluid inclusions trapped in minerals as the fractures heal are characteristic of the fluids that formed them, and this signature can be seen in fluid inclusion gas analysis. Our hypothesis is that fractures over their life cycle have different chemical signatures that we can see in fluid inclusion gas analysis and by using the new method of fluid inclusion stratigraphy (FIS) the different stages of fractures, along with an estimate of fracture size can be identified during the well drilling process. We have shown with this study that it is possible to identify fracture locations using FIS and that different fractures have different chemical signatures however that signature is somewhat dependent upon rock type. Open, active fractures correlate with increase concentrations of CO2, N2, Ar, and to a lesser extent H2O. These fractures would be targets for further enhancement. The usefulness of this method is that it is low cost alternative to current well logging techniques and can be done as a well is being drilled.

  7. Solid tags for identifying failed reactor components

    DOE Patents [OSTI]

    Bunch, Wilbur L. (Richland, WA); Schenter, Robert E. (Richland, WA)

    1987-01-01

    A solid tag material which generates stable detectable, identifiable, and measurable isotopic gases on exposure to a neutron flux to be placed in a nuclear reactor component, particularly a fuel element, in order to identify the reactor component in event of its failure. Several tag materials consisting of salts which generate a multiplicity of gaseous isotopes in predetermined ratios are used to identify different reactor components.

  8. NREL Research Identifies Increased Potential for Perovskites...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Identifies Increased Potential for Perovskites as a Material for Solar Cells October 30, 2015 Scientists at the Energy Department's National Renewable Energy Laboratory...

  9. High Power Target Design and Operational Considerations

    E-Print Network [OSTI]

    McDonald, Kirk

    of Energy SNS Target Systems and Status Update Target R&D Program Has Addressed Key Design and Operational-Battelle for the U.S. Department of Energy SNS Target Systems and Status Update Mercury target development activities.S. Department of Energy SNS Target Systems and Status Update · Peak energy deposition in Hg for a single pulse

  10. Targets for Multimegawatt Proton Beams %%%%%%%%%%%%%%%&'())0

    E-Print Network [OSTI]

    McDonald, Kirk

    , 2003 http://puhep1.princeton.edu/mumu/target/ Sketches of a 4-MW Target Station Kirk T. Mc and granular targets. · Liquid target studies. · Continuing R&D (including targets for linear colliders). Kirk accelerator neutrino beams, where targetry is a major challenge. Kirk T. McDonald Fermilab Long Range Planning

  11. Selection and optimization of gene targets for the metabolic engineering of E. coli

    E-Print Network [OSTI]

    Fischer, Curt R., Ph. D. Massachusetts Institute of Technology

    2009-01-01

    This thesis is about identifying genetic interventions that improve the performance of targeted pathways in the metabolism of the bacterium Escherichia coli. Three case studies illustrate three disparate approaches to ...

  12. Double spin asymmetries of inclusive hadron electroproduction from a transversely polarized [superscript 3]He target

    E-Print Network [OSTI]

    Zhao, Y. X.

    We report the measurement of beam-target double spin asymmetries (A[subscript LT]) in the inclusive production of identified hadrons, [? over e] + [superscript 3]He[superscript ?] ? h + X, using a longitudinally polarized ...

  13. Autonomous navigation and tracking of dynamic surface targets on-board a computationally impoverished aerial vehicle

    E-Print Network [OSTI]

    Selby, William Clayton

    2011-01-01

    This thesis describes the development of an independent, on-board visual servoing system which allows a computationally impoverished aerial vehicle to autonomously identify and track a dynamic surface target. Image ...

  14. Modulation of Ago-miRNA regulatory networks by cis-sequence elements and target competition

    E-Print Network [OSTI]

    Bosson, Andrew D. (Andrew David)

    2014-01-01

    regulators of gene expression in a wide range of organisms and biological processes. Each miRNA guides Argonaute (Ago) protein complexes to target and repress hundreds of genes in a sequence-dependent manner. To identify ...

  15. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome

    E-Print Network [OSTI]

    Jevtov, Irena

    Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target ...

  16. Proceedings of the Tungsten Workshop for Hard Target Weapons Program

    SciTech Connect (OSTI)

    Mackiewicz-Ludtka, G.; Hayden, H.W.; Davis, R.M.

    1995-06-01

    The purpose of this meeting was to review and exchange information and provide technical input for improving technologies relevant to the Hard Target Weapons Program. This workshop was attended by representatives from 17 organizations, including 4 Department of Defense (DoD) agencies, 8 industrial companies, and 5 laboratories within DOE. Hard targets are defined as reinforced underground structures that house enemy forces, weapon systems, and support equipment. DOE-ORO and Martin Marietta Energy Systems, Inc. (Energy Systems) have been involved in advanced materials research and development (R&D) for several DOE and DoD programs. These programs are conducted in close collaboration with Eglin AFB, Department of the Army`s Picatinny Arsenal, and other DoD agencies. As part of this ongoing collaboration, Eglin AFB and Oak Ridge National Laboratory planned and conducted this workshop to support the Hard Target Weapons Program. The objectives of this workshop were to (1) review and identify the technology base that exists (primarily due to anti-armor applications) and assess the applicability of this technology to the Hard Target Weapons Program requirements; (2) determine future directions to establish the W materials, processing, and manufacturing technologies suitable for use in fixed, hard target penetrators; and (3) identify and prioritize the potential areas for technical collaboration among the participants.

  17. DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery

    E-Print Network [OSTI]

    Brickner, Jason

    ARTICLES DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery are recruited to the nuclear periphery after transcriptional activation. We have identified two gene recruitment sequences (GRS I and II) from the promoter of the INO1 gene that target the gene to the nuclear periphery

  18. Incentive Price Revision-Successive Targets UT-B Contracts Div Page 1 of 3

    E-Print Network [OSTI]

    Incentive Price Revision-Successive Targets UT-B Contracts Div Jan 2006 Page 1 of 3 incent-price-rev-suc-ext-utbx-jan06.doc INCENTIVE PRICE REVISION - SUCCESSIVE TARGETS (Jan 2006) (a) General. The supplies or services identified in the Agreement as item numbers ______ are subject to price revision in accordance

  19. Incentive Price Revision Firm Target UT-B Contracts Div Page 1 of 2

    E-Print Network [OSTI]

    Incentive Price Revision ­ Firm Target UT-B Contracts Div Jan 2006 Page 1 of 2 incent-price-rev-firm-ext-utbx-jan06.doc INCENTIVE PRICE REVISION - FIRM TARGET (Jan 2006) (a) General. The supplies or services identified in the Agreement as item numbers __________ are subject to price revision in accordance

  20. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  1. Identifying and Protecting Official Use Only Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-09

    The order establishes a program within DOE and NNSA to identify certain unclassified controlled information as Official Use Only (OUO) and to identify, mark, and protect documents containing such information. Chg 1 dated 1-12-11, supersedes DOE O 471.3.

  2. Guide to Identifying Official Use Only Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-09

    This Guide supplements information contained in Department of Energy (DOE) O 471.3, Identifying and Protecting Official Use Only Information, dated 4-9-03, and DOE M 471.3-1, Manual for Identifying and Protecting Official Use Only Information, dated 4-9-03.

  3. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

  4. Identifying Best Practices in Hydraulic Fracturing Using

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Identifying Best Practices in Hydraulic Fracturing Using Virtual Intelligence Techniques SPE 72385 Results & Discussion Conclusion #12;SPE 72385 OBJECTIVE To identify Best Practices in Hydraulic Fracturing, are fractured upon completion to provide economic amounts of gas. #12;SPE 72385 BACKGROUND A dataset

  5. Monotonic Target Assignment for Robotic Networks

    E-Print Network [OSTI]

    Smith, Stephen L; Bullo, Francesco

    2009-01-01

    Target assignment for robotic networks: Worst-case andTARGET ASSIGNMENT FOR ROBOTIC NETWORKS [6] H. W. Kuhn, “TheTarget Assignment for Robotic Networks Stephen L. Smith,

  6. Transmission Line MTF: Magnetized Target Fusion

    E-Print Network [OSTI]

    Transmission Line MTF: Magnetized Target Fusion Initial target: preheated & magnetized Subsequent for the FRC. Abstract Block Diagram theta coil transmission line Bias cap. bank maincapacitor inductor PI cap

  7. Enterprise Assessments Targeted Review, Argonne National Laboratory...

    Energy Savers [EERE]

    Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 November 2014 Review of the...

  8. A Prospective Target for Advanced Biofuel Production

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

  9. Method To Identify Specific Inhibiutors Of Imp Dehydrogenase

    DOE Patents [OSTI]

    Collart, Frank R. (Bolingbrook, IL); Huberman, Eliezer (LaGrange, IL)

    2000-11-28

    This invention relates to methods to identify specific inhibitors of the purine nucleotide synthesis enzyme, IMP dehydrogenase (IMPDH). IMPDH is an essential enzyme found in all free-living organisms from humans to bacteria and is an important therapeutic target. The invention allows the identification of specific inhibitors of any IMPDH enzyme which can be expressed in a functional form in a recombinant host cell. A variety of eukaryotic or prokaryotic host systems commonly used for the expression of recombinant proteins are suitable for the practice of the invention. The methods are amenable to high throughput systems for the screening of inhibitors generated by combinatorial chemistry or other methods such as antisense molecule production. Utilization of exogenous guanosine as a control component of the methods allows for the identification of inhibitors specific for IMPDH rather than other causes of decreased cell proliferation.

  10. IDENTIFYING CANDIDATE PROTEIN FOR REMOVAL OF ENVIRONMENTALLY

    E-Print Network [OSTI]

    Uppsala Universitet

    IDENTIFYING CANDIDATE PROTEIN FOR REMOVAL OF ENVIRONMENTALLY HAZARDOUS SUBSTANCES Pharem Biotech products and technologies for removing environmental hazardous substances in our everyday life. The products can be applied in areas from the private customer up to the global corporate perspective

  11. Identifying Opportunities for Industrial Energy Conservation 

    E-Print Network [OSTI]

    Hoffman, A. R.

    1981-01-01

    The Energy Productivity Center of the Mellon Institute is engaged in a 2-year study to identify opportunities for improved U.S. industrial energy productivity. A distinguishing feature is the focus on energy services provided when fuels are consumed...

  12. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S. Coal StocksSuppliers Tag:TakeSeptember 13,Tara

  13. IDENTIFYING COLLISIONAL FAMILIES IN THE KUIPER BELT

    SciTech Connect (OSTI)

    Marcus, Robert A.; Ragozzine, Darin; Murray-Clay, Ruth A.; Holman, Matthew J., E-mail: rmarcus@cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2011-05-20

    The identification and characterization of numerous collisional families-clusters of bodies with a common collisional origin-in the asteroid belt has added greatly to the understanding of asteroid belt formation and evolution. More recent study has also led to an appreciation of physical processes that had previously been neglected (e.g., the Yarkovsky effect). Collisions have certainly played an important role in the evolution of the Kuiper Belt as well, though only one collisional family has been identified in that region to date, around the dwarf planet Haumea. In this paper, we combine insights into collisional families from numerical simulations with the current observational constraints on the dynamical structure of the Kuiper Belt to investigate the ideal sizes and locations for identifying collisional families. We find that larger progenitors (r {approx} 500 km) result in more easily identifiable families, given the difficulty in identifying fragments of smaller progenitors in magnitude-limited surveys, despite their larger spread and less frequent occurrence. However, even these families do not stand out well from the background. Identifying families as statistical overdensities is much easier than characterizing families by distinguishing individual members from interlopers. Such identification seems promising, provided the background population is well known. In either case, families will also be much easier to study where the background population is small, i.e., at high inclinations. Overall, our results indicate that entirely different techniques for identifying families will be needed for the Kuiper Belt, and we provide some suggestions.

  14. Mercury Intense Target (MERIT) Update

    E-Print Network [OSTI]

    McDonald, Kirk

    requirement for the system to deliver a 20 m/s jet - Two hydraulic cylinders drive a Hg cylinder - Stainless with Airline Hydraulics Co. today!) (2) Target Delivery System - Consists of primary and secondary containments, unconstrained jet of Hg in 1-atmosphere of air, into 15 Tesla field (Vacuum Is Under Review) #12;8 OAK RIDGE

  15. Identifying Geographic Clusters: A Network Analytic Approach

    E-Print Network [OSTI]

    Catini, Roberto; Penner, Orion; Riccaboni, Massimo

    2015-01-01

    In recent years there has been a growing interest in the role of networks and clusters in the global economy. Despite being a popular research topic in economics, sociology and urban studies, geographical clustering of human activity has often studied been by means of predetermined geographical units such as administrative divisions and metropolitan areas. This approach is intrinsically time invariant and it does not allow one to differentiate between different activities. Our goal in this paper is to present a new methodology for identifying clusters, that can be applied to different empirical settings. We use a graph approach based on k-shell decomposition to analyze world biomedical research clusters based on PubMed scientific publications. We identify research institutions and locate their activities in geographical clusters. Leading areas of scientific production and their top performing research institutions are consistently identified at different geographic scales.

  16. Scientometric methods for identifying emerging technologies

    DOE Patents [OSTI]

    Abercrombie, Robert K; Schlicher, Bob G; Sheldon, Frederick T

    2015-11-03

    Provided is a method of generating a scientometric model that tracks the emergence of an identified technology from initial discovery (via original scientific and conference literature), through critical discoveries (via original scientific, conference literature and patents), transitioning through Technology Readiness Levels (TRLs) and ultimately on to commercial application. During the period of innovation and technology transfer, the impact of scholarly works, patents and on-line web news sources are identified. As trends develop, currency of citations, collaboration indicators, and on-line news patterns are identified. The combinations of four distinct and separate searchable on-line networked sources (i.e., scholarly publications and citation, worldwide patents, news archives, and on-line mapping networks) are assembled to become one collective network (a dataset for analysis of relations). This established network becomes the basis from which to quickly analyze the temporal flow of activity (searchable events) for the example subject domain.

  17. Identify Institutional Change Roles for Sustainability

    Broader source: Energy.gov [DOE]

    To achieve the sustainability goals you've identified, take into account the network of roles essential to make or maintain the desired changes. As a rule of thumb, it may help to think about what roles are necessary for determining what changes to make, implementing those changes, and supporting or abiding by those changes. One place to start is by identifying leaders in your organization who have the authority, resources, and influence to make change happen. Those leadership roles typically include: Senior management Policy and technology officers Facilities and operations managers.

  18. Identifying Water Savings in Industrial Operations 

    E-Print Network [OSTI]

    Theising, T.

    2015-01-01

    Solutions, L.L.C. Identifying Water Savings in Industrial Operations IETC June 4, 2015 Tom Theising, C.E.M., C.D.S.M. (979) 709-6389 tom.theising@yahoo.com ESL-IE-15-06-23a Proceedings of the Thrity-Seventh Industrial Energy Technology Conference New... Orleans, LA. June 2-4, 2015 SES Sustainable Energy Solutions, L.L.C. Energy Optimization Services: • Energy Efficiency Evaluation • Energy Management Program Development • Energy Maintenance Best Practices Energy Reliability Services: • Identify solutions...

  19. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1984-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  20. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1987-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  1. Identifying the Theory of Dark Matter with Direct Detection

    E-Print Network [OSTI]

    Vera Gluscevic; Moira I. Gresham; Samuel D. McDermott; Annika H. G. Peter; Kathryn M. Zurek

    2015-06-15

    Identifying the true theory of dark matter depends crucially on accurately characterizing interactions of dark matter (DM) with other species. In the context of DM direct detection, we present a study of the prospects for correctly identifying the low-energy effective DM-nucleus scattering operators connected to UV-complete models of DM-quark interactions. We take a census of plausible UV-complete interaction models with different low-energy leading-order DM-nuclear responses. For each model (corresponding to different spin-, momentum-, and velocity-dependent responses), we create a large number of realizations of recoil-energy spectra, and use Bayesian methods to investigate the probability that experiments will be able to select the correct scattering model within a broad set of competing scattering hypotheses. We conclude that agnostic analysis of a strong signal (such as Generation-2 would see if cross sections are just below the current limits) seen on xenon and germanium experiments is likely to correctly identify momentum dependence of the dominant response, ruling out models with either "heavy" or "light" mediators, and enabling downselection of allowed models. However, a unique determination of the correct UV completion will critically depend on the availability of measurements from a wider variety of nuclear targets, including iodine or fluorine. We investigate how model-selection prospects depend on the energy window available for the analysis. In addition, we discuss accuracy of the DM particle mass determination under a wide variety of scattering models, and investigate impact of the specific types of particle-physics uncertainties on prospects for model selection.

  2. Identifying the Host Galaxy of Gravitational Wave Signals

    E-Print Network [OSTI]

    Laura K Nuttall; Patrick J Sutton

    2011-11-29

    One of the goals of the current LIGO-GEO-Virgo science run is to identify transient gravitational wave (GW) signals in near real time to allow follow-up electromagnetic (EM) observations. An EM counterpart could increase the confidence of the GW detection and provide insight into the nature of the source. Current GW-EM campaigns target potential host galaxies based on overlap with the GW sky error box. We propose a new statistic to identify the most likely host galaxy, ranking galaxies based on their position, distance, and luminosity. We test our statistic with Monte Carlo simulations of GWs produced by coalescing binaries of neutron stars (NS) and black holes (BH), one of the most promising sources for ground-based GW detectors. Considering signals accessible to current detectors, we find that when imaging a single galaxy, our statistic correctly identifies the true host ~20% to ~50% of the time, depending on the masses of the binary components. With five narrow-field images the probability of imaging the true host increases to ~50% to ~80%. When collectively imaging groups of galaxies using large field-of-view telescopes, the probability improves to ~30% to ~60% for a single image and to ~70% to ~90% for five images. For the advanced generation of detectors (c. 2015+), and considering binaries within 100 Mpc (the reach of the galaxy catalogue used), the probability is ~40% for one narrow-field image, ~75% for five narrow-field images, ~65% for one wide-field image, and ~95% for five wide-field images, irrespective of binary type.

  3. Identifying Lights with their Switches Jayadev Misra

    E-Print Network [OSTI]

    Misra, Jayadev

    Identifying Lights with their Switches Jayadev Misra 09/07/2012 Problem Description Given are N switches and N lights where each switch controls exactly one light and each light is controlled by exactly one switch. The wiring diagram is unavailable and the wiring itself is hidden. A step consists

  4. Identifying Relevant Databases for Multidatabase Mining

    E-Print Network [OSTI]

    Liu, Huan

    Identifying Relevant Databases for Multidatabase Mining Huan Liu, Hongjun Lu, Jun Yao Department,luhj,yaojung@iscs.nus.edu.sg Abstract. Various tools and systems for knowledge discovery and data mining are developed and available is where we should start mining. In this paper, breaking away from the conventional data mining assumption

  5. Diffraction gratings used as identifying markers

    DOE Patents [OSTI]

    Deason, Vance A. (Idaho Falls, ID); Ward, Michael B. (Idaho Falls, ID)

    1991-01-01

    A finely detailed defraction grating is applied to an object as an identifier or tag which is unambiguous, difficult to duplicate, or remove and transfer to another item, and can be read and compared with prior readings with relative ease. The exact pattern of the defraction grating is mapped by diffraction moire techniques and recorded for comparison with future readings of the same grating.

  6. Call Identifier: CIP-IEE-2009

    E-Print Network [OSTI]

    De Cindio, Fiorella

    ://ec.europa.eu/intelligentenergy #12;Intelligent Energy ­ Europe Call for Proposals 2009 2/17 CALL FOR PROPOSALS 2009 FOR ACTIONS UNDER THE PROGRAMME "INTELLIGENT ENERGY ­ EUROPE" Call Identifier: CIP-IEE-2009 TABLE OF CONTENTS 1. THE INTELLIGENT ENERGY ­ EUROPE PROGRAMME 3 2. BUDGET, FUNDING RATES AND ELIGIBILITY OF COSTS 5 3. ELIGIBILITY CRITERIA 5

  7. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  8. Consistent nonlinear dynamics: identifying model inadequacy

    E-Print Network [OSTI]

    Patrick E. McSharry; Leonard A. Smith

    2004-03-09

    Empirical modelling often aims for the simplest model consistent with the data. A new technique is presented which quantifies the consistency of the model dynamics as a function of location in state space. As is well-known, traditional statistics of nonlinear models like root-mean-square (RMS) forecast error can prove misleading. Testing consistency is shown to overcome some of the deficiencies of RMS error, both within the perfect model scenario and when applied to data from several physical systems using previously published models. In particular, testing for consistent nonlinear dynamics provides insight towards (i) identifying when a delay reconstruction fails to be an embedding, (ii) allowing state dependent model selection and (iii) optimising local neighbourhood size. It also provides a more relevant (state dependent) threshold for identifying false nearest neighbours.

  9. Guidelines for identifying suspect/counterfeit material

    SciTech Connect (OSTI)

    NONE

    1995-09-01

    These guidelines are intended to assist users of products in identifying: substandard, misrepresented, or fraudulently marked items. The guidelines provide information about such topics as: precautions, inspection and testing, dispositioning identified items, installed inspection and reporting suspect/counterfeit materials. These guidelines apply to users who are developing procurement documents, product acceptance/verification methods, company procedures, work instructions, etc. The intent of these SM guidelines in relation to the Quality Assurance Program Description (QAPD) and implementing company Management Control Procedures is not to substitute or replace existing requirements, as defined in either the QAPD or company implementing instructions (Management Control Procedures). Instead, the guidelines are intended to provide a consolidated source of information addressing the issue of Suspect/Counterfeit materials. These guidelines provide an extensive suspect component listing and suspect indications listing. Users can quickly check their suspect items against the list of manufacturers products (i.e., type, LD. number, and nameplate information) by consulting either of these listings.

  10. Diffraction gratings used as identifying markers

    DOE Patents [OSTI]

    Deason, V.A.; Ward, M.B.

    1991-03-26

    A finely detailed diffraction grating is applied to an object as an identifier or tag which is unambiguous, difficult to duplicate, or remove and transfer to another item, and can be read and compared with prior readings with relative ease. The exact pattern of the diffraction grating is mapped by diffraction moire techniques and recorded for comparison with future readings of the same grating. 7 figures.

  11. Identify Potential HITs | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingREnergy Tools for Sustainability Identify

  12. Identifying Needs and Goals | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy ServicesContractingManagement »HydrogenINTERACTIVE:Identify

  13. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z.

    2013-11-15

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  14. Small Molecule Target Identification using Drug Affinity Responsive Target Stability (DARTS)

    E-Print Network [OSTI]

    Lomenick, Brett Eugene

    2013-01-01

    FIGURE 2.8: Resveratrol does not inhibitFIGURE 2.9: Resveratrol target analysis withFIGURE 2.10: Resveratrol target analysis with

  15. Review of the Renewable Energy Target

    E-Print Network [OSTI]

    Peters, Richard

    Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

  16. Targets and processes for fabricating same

    SciTech Connect (OSTI)

    Cowna, Thomas; Malekos, Steven; Korgan, Grant; Adams, Jesse; Sentoku, Yasuhiko; LeGalloudec, Nathalie

    2014-06-10

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  17. Nanoparticles for targeting the infarcted heart

    E-Print Network [OSTI]

    Dvir, Tal

    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

  18. Solid Target Studies for NF Rob Edgecock

    E-Print Network [OSTI]

    McDonald, Kirk

    . Proposed lubricant (coating): WS2 Demonstrated to work to ~1300oC in vacuum. #12;Target Change #12;Target Calculations and Optimisation. John 4. Chain Design Optimisation ­ roller chain or alternative. David Consult

  19. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

    2012-07-24

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  20. Enterprise Assessments, Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - November 2013 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Review, West Valley Demonstration Project - December...

  1. A TUTORIAL ON IGNITION AND GAIN FOR SMALL FUSION TARGETS

    SciTech Connect (OSTI)

    Kirkpatrick, R. C. [Los Alamos National Laboratory, Los Alamos, NM 087545 (United States)

    2009-07-26

    Nuclear fusion was discovered experimentally in 1933-34 and other charged particle nuclear reactions were documented shortly thereafter. Work in earnest on the fusion ignition problem began with Edward Teller's group at Los Alamos during the war years. His group quantified all the important basic atomic and nuclear processes and summarized their interactions. A few years later, the success of the early theory developed at Los Alamos led to very successful thermonuclear weapons, but also to decades of unsuccessful attempts to harness fusion as an energy source of the future. The reasons for this history are many, but it seems appropriate to review some of the basics with the objective of identifying what is essential for success and what is not. This tutorial discusses only the conditions required for ignition in small fusion targets and how the target design impacts driver requirements. Generally speaking, the driver must meet the energy, power and power density requirements needed by the fusion target. The most relevant parameters for ignition of the fusion fuel are the minimum temperature and areal density (rhoR), but these parameters set secondary conditions that must be achieved, namely an implosion velocity, target size and pressure, which are interrelated. Despite the apparent simplicity of inertial fusion targets, there is not a single mode of fusion ignition, and the necessary combination of minimum temperature and areal density depends on the mode of ignition. However, by providing a magnetic field of sufficient strength, the conditions needed for fusion ignition can be drastically altered. Magnetized target fusion potentially opens up a vast parameter space between the extremes of magnetic and inertial fusion.

  2. Automatic Target Word Disambiguation Using Syntactic Relationships

    E-Print Network [OSTI]

    Automatic Target Word Disambiguation Using Syntactic Relationships Ebony Domingo1 and Rachel Edita. Multiple target translations are due to several meanings of source words, and various target word equivalents depending on the context of the source word. Thus, an automated approach is presented

  3. Predicting new molecular targets for known drugs

    E-Print Network [OSTI]

    Kaski, Samuel

    ARTICLES Predicting new molecular targets for known drugs Michael J. Keiser1,2 *, Vincent Setola3 drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug­target combinations exist, it would be useful to explore possible

  4. Drug-Target Interaction Predicates Combining Similarities

    E-Print Network [OSTI]

    Daume III, Hal

    Drug-Target Interaction Predicates DataSet Combining Similarities Collective Inference Collective Inference and Multi-Relational Learning for Drug­Target Interaction Prediction Shobeir Fakhraei1, Bert Huang1 and Lise Getoor1,2 Poly-pharmacology Drug Repurposing Drug-Target Interaction Network Studies

  5. Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors

    E-Print Network [OSTI]

    Barrett, Tristan; Patterson, Andrew J.; Koo, Brendan C.; Wadhwa, Karan; Warren, Anne Y.; Doble, Andrew; Gnanapragasam, Vincent J.; Kastner, Christof; Gallagher, Ferdia A.

    2015-01-01

    platform (Medcom, Darmstadt, Germany). Briefly, a transrectal ultrasound probe is inserted and mounted on a brachytherapy gantry with a template grid for transperineal needle placement in the prostate. MR images are co-registered to ultrasound images...

  6. Remyelination failure following white matter stroke: new targets for repair identified by oligodendrocyte progenitor cell transcriptome database.

    E-Print Network [OSTI]

    Sozmen, Elif Guler

    2013-01-01

    CS, Brosnan CF (2002) Multiple sclerosis: re-expression of afailure in chronic multiple sclerosis. Brain 131:1749-1758.extensive in a subset of multiple sclerosis patients. Brain

  7. Optimizing Building Energy Use Objective: Perform a comprehensive energy audit of a targeted New York City building,

    E-Print Network [OSTI]

    Wolberg, George

    Optimizing Building Energy Use Objective: Perform a comprehensive energy audit of a targeted New York City building, identify inefficiencies, recommend modifications to improve energy efficiency, electricity-generation method, and the energy efficiency of buildings. Building energy efficiency determines

  8. Method of identifying defective particle coatings

    DOE Patents [OSTI]

    Cohen, Mark E. (San Diego, CA); Whiting, Carlton D. (San Diego, CA)

    1986-01-01

    A method for identifying coated particles having defective coatings desig to retain therewithin a build-up of gaseous materials including: (a) Pulling a vacuum on the particles; (b) Backfilling the particles at atmospheric pressure with a liquid capable of wetting the exterior surface of the coated particles, said liquid being a compound which includes an element having an atomic number higher than the highest atomic number of any element in the composition which forms the exterior surface of the particle coating; (c) Drying the particles; and (d) Radiographing the particles. By television monitoring, examination of the radiographs is substantially enhanced.

  9. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    BIOLOGY; CENTRAL NERVOUS SYSTEM; DISEASES; DISSOCIATION; NERVES; ORGANS; POTASSIUM; PROTEINS; REGULATIONS; RESIDUES; TARGETS; TYROSINE",,"The parasympathetic branch of the...

  10. PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES

    SciTech Connect (OSTI)

    Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

    2014-01-01

    A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

  11. IDENTIFYING THE RADIO BUBBLE NATURE OF THE MICROWAVE HAZE

    SciTech Connect (OSTI)

    Dobler, Gregory, E-mail: dobler@kitp.ucsb.edu [Kavli Institute for Theoretical Physics, University of California, Santa Barbara Kohn Hall, Santa Barbara, CA 93106 (United States)

    2012-11-20

    Using seven-year data from the Wilkinson Microwave Anisotropy Probe, I identify a sharp 'edge' in the microwave haze at high southern Galactic latitude (-55 Degree-Sign < b < -35 Degree-Sign ) that is spatially coincident with the southern edge of the 'Fermi haze/bubbles'. This finding proves conclusively that the edge in the gamma rays is real (and not a processing artifact), demonstrates explicitly that the microwave haze and the gamma-ray bubbles are indeed the same structure observed at multiple wavelengths, and strongly supports the interpretation of the microwave haze as a separate component of Galactic synchrotron (likely generated by a transient event) as opposed to a simple variation of the spectral index of disk synchrotron. In addition, combining these data sets allows for the first determination of the magnetic field within a radio bubble using microwaves and gamma rays by taking advantage of the fact that the inverse Compton gamma rays are primarily generated by scattering of cosmic microwave background photons at these latitudes, thus minimizing uncertainty in the target radiation field. Assuming uniform volume emissivity, I find that the magnetic field within the southern Galactic microwave/gamma-ray bubble is {approx}5 {mu}G above 6 kpc off of the Galactic plane.

  12. Terahertz-based target typing.

    SciTech Connect (OSTI)

    Lyo, Sungkwun Kenneth; Wanke, Michael Clement; Reno, John Louis; Shaner, Eric Arthur; Grine, Albert D.; Barrick, Todd A.

    2008-09-01

    The purpose of this work was to create a THz component set and understanding to aid in the rapid analysis of transient events. This includes the development of fast, tunable, THz detectors, along with filter components for use with standard detectors and accompanying models to simulate detonation signatures. The signature effort was crucial in order to know the spectral range to target for detection. Our approach for frequency agile detection was to utilize plasmons in the channel of a specially designed field-effect transistor called the grating-gate detector. Grating-gate detectors exhibit narrow-linewidth, broad spectral tunability through application of a gate bias, and no angular dependence in their photoresponse. As such, if suitable sensitivity can be attained, they are viable candidates for Terahertz multi-spectral focal plane arrays.

  13. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  14. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

    1995-01-01

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  15. Target Fabrication: A View from the Users

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Barnes, Cris W.; Batha, Steven H.; Christensen, Cindy R.; Cobble, James A.; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael; Swift, Damian; Workman, Jonathan

    2004-03-15

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  16. TARGET FABRICATION: A VIEW FROM THE USERS.

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Batha, Steven H.; Barnes, Cris W.; Christensen, Cindy; Cobble, James; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael S.; Swift, Damian; Workman, Jonathan

    2003-07-18

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in time to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  17. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  18. Method of identifying features in indexed data

    DOE Patents [OSTI]

    Jarman, Kristin H. (Richland, WA) [Richland, WA; Daly, Don Simone (Richland, WA) [Richland, WA; Anderson, Kevin K. (Richland, WA) [Richland, WA; Wahl, Karen L. (Richland, WA) [Richland, WA

    2001-06-26

    The present invention is a method of identifying features in indexed data, especially useful for distinguishing signal from noise in data provided as a plurality of ordered pairs. Each of the plurality of ordered pairs has an index and a response. The method has the steps of: (a) providing an index window having a first window end located on a first index and extending across a plurality of indices to a second window end; (b) selecting responses corresponding to the plurality of indices within the index window and computing a measure of dispersion of the responses; and (c) comparing the measure of dispersion to a dispersion critical value. Advantages of the present invention include minimizing signal to noise ratio, signal drift, varying baseline signal and combinations thereof.

  19. Identifying the structural discontinuities of human interactions

    E-Print Network [OSTI]

    Grauwin, Sebastian; Sobolevsky, Stanislav; Hövel, Philipp; Simini, Filippo; Vanhoof, Maarten; Smoreda, Zbigniew; Barabasi, Albert-Laszlo; Ratti, Carlo

    2015-01-01

    The idea of a hierarchical spatial organization of society lies at the core of seminal theories in human geography that have strongly influenced our understanding of social organization. In the same line, the recent availability of large-scale human mobility and communication data has offered novel quantitative insights hinting at a strong geographical confinement of human interactions within neighboring regions, extending to local levels within countries. However, models of human interaction largely ignore this effect. Here, we analyze several country-wide networks of telephone calls and uncover a systematic decrease of communication induced by borders which we identify as the missing variable in state-of-the-art models. Using this empirical evidence, we propose an alternative modeling framework that naturally stylize the damping effect of borders. We show that this new notion substantially improves the predictive power of widely used interaction models, thus increasing our ability to predict social activiti...

  20. Vulnerability of critical infrastructures : identifying critical nodes.

    SciTech Connect (OSTI)

    Cox, Roger Gary; Robinson, David Gerald

    2004-06-01

    The objective of this research was the development of tools and techniques for the identification of critical nodes within critical infrastructures. These are nodes that, if disrupted through natural events or terrorist action, would cause the most widespread, immediate damage. This research focuses on one particular element of the national infrastructure: the bulk power system. Through the identification of critical elements and the quantification of the consequences of their failure, site-specific vulnerability analyses can be focused at those locations where additional security measures could be effectively implemented. In particular, with appropriate sizing and placement within the grid, distributed generation in the form of regional power parks may reduce or even prevent the impact of widespread network power outages. Even without additional security measures, increased awareness of sensitive power grid locations can provide a basis for more effective national, state and local emergency planning. A number of methods for identifying critical nodes were investigated: small-world (or network theory), polyhedral dynamics, and an artificial intelligence-based search method - particle swarm optimization. PSO was found to be the only viable approach and was applied to a variety of industry accepted test networks to validate the ability of the approach to identify sets of critical nodes. The approach was coded in a software package called Buzzard and integrated with a traditional power flow code. A number of industry accepted test networks were employed to validate the approach. The techniques (and software) are not unique to power grid network, but could be applied to a variety of complex, interacting infrastructures.

  1. Influence of Translation Initiation on Organellar Protein Targeting in Arabidopsis

    SciTech Connect (OSTI)

    Sally A. Mackenzie

    2011-04-18

    A primary focus of the Mackenzie laboratory is the elucidation of processes and machinery for mitochondrial genome maintenance and transmission in higher plants. We have found that numerous organellar DNA maintenance components in plants appear to be dual targeted to mitochondria and plastids. Of particular interest was the observation that some twin (tandemly arrayed) dual targeting presequences appeared to utilize non-AUG alternative translation initiation, allowing for multiple translation starts at a single gene. Two aspects of this phenomenon were of particular interest: (1) Alternative translation initiation might provide a mechanism to regulate protein targeting temporally and spatially, a possibility that had not been demonstrated previously, and (2) alternative translation initiation might occur in genes involved in nuclear-controlled mitochondrial genome recombination, thought to be exclusively mitochondrial in their function. During the course of this research, we pursued three aims, with an emphasis on two specific genes of interest: POLgamma2, an organellar DNA polymerase, and MSH1, a MutS homolog thought to participate in mitochondrial, but not plastid, genome recombination surveillance. Our aims were to (1) Identify additional genes within Arabidopsis and other genomes that employ non-AUG alternative translation initiation, (2) Locate sequences upstream to the annotated AUG that confer alternative non-AUG translation initiation activity, and (3) Identify cis and trans factors that influence start site selection in genes with non-AUG starts. Toward these ends, we have shown that non-AUG initiation occurs in a number of genes, likely influencing targeting behavior of the protein. We have also shown that start site selection is strongly influenced by Kozak consensus sequence environment, indicating that alternative translation initiation in plants occurs by relaxation of ribosome scanning.

  2. Table I: Technical Targets for Catalyst Coated Membranes (CCMs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Table I: Technical Targets for Catalyst Coated Membranes (CCMs): Automotive Technical targets for fuel cell...

  3. Liquid Hydrogen Target for the COMPASS experiment

    E-Print Network [OSTI]

    Bremer, J; Duday-Chanat, L; Geyer, R; Mallot, G K; Pirotte, O; Vullierme, B

    2014-01-01

    A liquid hydrogen target has been developed for the COMPASS experiment at CERN. The target has a diameter of 40 mm and a length of 2.5 meter, creating an active volume of about 3 liter of liquid hydrogen. The cylindrical part of the target wall is formed by a Kapton® foil strip, wound and glued to a thickness of 0.125 mm. The Kapton® foil is used to minimize the energy loss of the particles, scattered or created within the target volume, crossing the target boundary. The two end-caps enclosing the target volume have been fabricated from Mylar®. The system is cooled with a 30 W at 20 K cryocooler, delivering the cooling capacity for the cool-down as well as for the continuous operation of the system.

  4. THERMAL OSCILLATIONS IN LIQUID HELIUM TARGETS.

    SciTech Connect (OSTI)

    WANG,L.; JIA,L.X.

    2001-07-16

    A liquid helium target for the high-energy physics was built and installed in the proton beam line at the Alternate Gradient Synchrotron of Brookhaven National Laboratory in 2001. The target flask has a liquid volume of 8.25 liters and is made of thin Mylar film. A G-M/J-T cryocooler of five-watts at 4.2K was used to produce liquid helium and refrigerate the target. A thermosyphon circuit for the target was connected to the J-T circuit by a liquid/gas separator. Because of the large heat load to the target and its long transfer lines, thermal oscillations were observed during the system tests. To eliminate the oscillation, a series of tests and analyses were carried out. This paper describes the phenomena and provides the understanding of the thermal oscillations in the target system.

  5. Identifying Wind and Solar Ramping Events: Preprint

    SciTech Connect (OSTI)

    Florita, A.; Hodge, B. M.; Orwig, K.

    2013-01-01

    Wind and solar power are playing an increasing role in the electrical grid, but their inherent power variability can augment uncertainties in power system operations. One solution to help mitigate the impacts and provide more flexibility is enhanced wind and solar power forecasting; however, its relative utility is also uncertain. Within the variability of solar and wind power, repercussions from large ramping events are of primary concern. At the same time, there is no clear definition of what constitutes a ramping event, with various criteria used in different operational areas. Here the Swinging Door Algorithm, originally used for data compression in trend logging, is applied to identify variable generation ramping events from historic operational data. The identification of ramps in a simple and automated fashion is a critical task that feeds into a larger work of 1) defining novel metrics for wind and solar power forecasting that attempt to capture the true impact of forecast errors on system operations and economics, and 2) informing various power system models in a data-driven manner for superior exploratory simulation research. Both allow inference on sensitivities and meaningful correlations, as well as the ability to quantify the value of probabilistic approaches for future use in practice.

  6. Identifying dark matter interactions in monojet searches

    SciTech Connect (OSTI)

    Agrawal, Prateek; Rentala, Vikram

    2014-05-01

    We study the discrimination of quark-initiated jets from gluon-initiated jets in monojet searches for dark matter using the technique of averaged jet energy profiles. We demonstrate our results in the context of effective field theories of dark matter interactions with quarks and gluons, but our methods apply more generally to a wide class of models. Different effective theories of dark matter and the standard model backgrounds each have a characteristic quark/gluon fraction for the leading jet. When used in conjunction with the traditional cut-and-count monojet search, the jet energy profile can be used to set stronger bounds on contact interactions of dark matter. In the event of a discovery of a monojet excess at the 14 TeV LHC, contact interactions between dark matter with quarks or with gluons can be differentiated at the 95% confidence level. For a given rate at the LHC, signal predictions at direct detection experiments for different dark matter interactions can span five orders of magnitude. The ability to identify these interactions allows us to make a tighter connection between LHC searches and direct detection experiments.

  7. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  8. Design Custom Messages for Specific Markets

    Broader source: Energy.gov [DOE]

    Presents tips and steps on how energy efficiency programs can create messages for targeted audiences.

  9. Enterprise Assessments Targeted Review, Sandia National Laboratories...

    Energy Savers [EERE]

    Nuclear Security Administration sites that perform work at nuclear facilities and other high consequence hazards (e.g., chemical and biological). This targeted review area also...

  10. Enterprise Assessments Targeted Review, Lawrence Livermore National...

    Office of Environmental Management (EM)

    National Laboratory - February 2015 February 2015 Targeted Review of the Safety-Class Room Ventilation Systems and Associated Final Filtration Stages, and Review of Federal...

  11. Project Plan Remote Target Fabrication Refurbishment Project

    SciTech Connect (OSTI)

    Bell, Gary L; Taylor, Robin D

    2009-08-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of {sup 252}Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The {sup 252}Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of {sup 252}Cf; the average irradiation period is {approx}10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of {sup 252}Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work was received in July 2009 under the Remote Target Fabrication Refurbishment Task of the Enhanced Utilization of Isotope Facilities project (Project Identification Code 2005230) funded by the American Recovery and Reinvestment Act of 2009. The goal of this project is to recover the capability to produce 4-5 curium targets for the irradiation period starting with HFIR cycle 427, currently scheduled to begin 2/17/10. Assuming success, the equipment would then be used to fabricate 6-7 additional targets to hold for the next irradiation campaign specified by the program. Specific objectives are the return to functionality of the Cubicle 3 Pellet Fabrication Line; Cubicle 2 Target Assembly equipment; and Cubicle 1 Target Inspection and Final Assembly system.

  12. Implications of structural genomics target selection strategies...

    Office of Scientific and Technical Information (OSTI)

    Implications of structural genomics target selection strategies: Pfam5000, whole genome, and random approaches Citation Details In-Document Search Title: Implications of structural...

  13. Setting Energy Savings Targets for Utilities

    SciTech Connect (OSTI)

    none,

    2011-09-01

    Helps policymakers understand how electric and natural gas utilities can achieve greater efficiency by establishing numeric energy savings targets and goals for energy efficiency programs.

  14. Rice University Policy No. 808 PROTECTION OF PERSONALLY IDENTIFIABLE INFORMATION

    E-Print Network [OSTI]

    Richards-Kortum, Rebecca

    Rice University Policy No. 808 PROTECTION OF PERSONALLY IDENTIFIABLE INFORMATION General Policy of confidential or sensitive personally identifiable information in conducting university business. Personally identifiable information is data which is tied to, or otherwise enables identification of, a specific person

  15. Identify Institutional Change Rules, Roles, and Tools Constituting...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Identify Institutional Change Rules, Roles, and Tools Constituting Context for Sustainability Identify Institutional Change Rules, Roles, and Tools Constituting Context for...

  16. A Workshop to Identify Research Needs and Impacts in Predictive...

    Office of Environmental Management (EM)

    to Identify Research Needs and Impacts in Predictive Simulation for Internal Combustion Engines (PreSICE) A Workshop to Identify Research Needs and Impacts in Predictive...

  17. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Its key project, the Genomics Encyclopedia of Fungi, targets fungi related to plant health (symbionts, pathogens, and biocontrol agents) and biorefinery processes (cellulose...

  18. Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets

    Broader source: Energy.gov [DOE]

    Summary of FreedomCAR Targets and Basis for Targets prepared for the Grand Challenge Hydrogen Storage Solicitation.

  19. Design Strategies for Self-Assembly of Discrete Targets

    E-Print Network [OSTI]

    Jim Madge; Mark A. Miller

    2015-08-11

    Both biological and artificial self-assembly processes can take place by a range of different schemes, from the successive addition of identical building blocks, to hierarchical sequences of intermediates, all the way to the fully addressable limit in which each component is unique. In this paper we introduce an idealized model of cubic particles with patterned faces that allows self-assembly strategies to be compared and tested. We consider a simple octameric target, starting with the minimal requirements for successful self-assembly and comparing the benefits and limitations of more sophisticated hierarchical and addressable schemes. Simulations are performed using a hybrid dynamical Monte Carlo protocol that allows self-assembling clusters to rearrange internally while still providing Stokes-Einstein-like diffusion of aggregates of different sizes. Our simulations explicitly capture the thermodynamic, dynamic and steric challenges typically faced by self-assembly processes, including competition between multiple partially-completed structures. Self-assembly pathways are extracted from the simulation trajectories by a fully extendable scheme for identifying structural fragments, which are then assembled into history diagrams for successfully completed target structures. For the simple target, a one-component assembly scheme is most efficient and robust overall, but hierarchical and addressable strategies can have an advantage under some conditions if high yield is a priority.

  20. A method for comparing impacts with real targets to impacts onto the IAEA unyielding target

    SciTech Connect (OSTI)

    Ammerman, D. J.

    1991-01-01

    The severity of the IAEA accident conditions test requirement (IAEA 1990) of an impact onto an essentially unyielding target from a drop height of 9 meters encompasses a large fraction of all real world impacts. This is true, in part, because of the unyielding nature of the impact target. Impacts onto the unyielding target have severities equivalent to higher velocity impacts onto real targets which are not unyielding. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. In demonstrating the severity of the regulatory impact event it is advantageous to be able to relate this impact onto an essentially unyielding target to impacts with yielding targets.

  1. Development of granular target for CADS

    E-Print Network [OSTI]

    McDonald, Kirk

    deposited by proton beam ~ X kW/cm^3 Industrial facility ~50MW=2.0GeV@25mA accelerator Spallation target, spheres, or plates to produce the neutrons, and coolant flowing between the elements for heat removal. · Liquid target options where a flowing liquid metal acts both as the source of neutrons and the heat

  2. TARGETING CANCER STEM CELLS Summary of technology

    E-Print Network [OSTI]

    Mucina, Ladislav

    TARGETING CANCER STEM CELLS Summary of technology Cancerstemcells(CSCs)playasignificantroleinleukemia, glioma, and breast, lung, gastrointestinal, prostate and ovarian cancer etiology, causing therapy of a new adjunct for targeted therapy of cancer involving CSCs, for use in combination with existing cancer

  3. Target Volatility Option Pricing Giuseppe Di Graziano

    E-Print Network [OSTI]

    Macrina, Andrea

    for the pricing of Target Volatility Options (TVOs), a recent market innovation in the eld of volatility are lower than the target volatility, the pay-o of the former is higher than the pay-o of the corresponding experi- enced a steep increase, with a signicant impact on option (long vega) costs. The generalized

  4. Technical Design Report, Second Target Station

    SciTech Connect (OSTI)

    Galambos, John D.; Anderson, David E.; Bechtol, D.; Bethea, Katie L.; Brown, N.; Carden, W. F.; Chae, Steven M.; Clark, A.; Counce, Deborah M.; Craft, K.; Crofford, Mark T.; Collins, Richard M.; Cousineau, Sarah M.; Curry, Douglas E.; Cutler, Roy I.; Dayton, Michael J.; Dean, Robert A.; Deibele, Craig E.; Doleans, Marc; Dye, T.; Eason, Bob H.; Eckroth, James A.; Fincrock, C.; Fritts, S.; Gallmeier, Franz X.; Gawne, Ken R.; Hartman, Steven M.; Herwig, Kenneth W.; Hess, S.; Holmes, Jeffrey A.; Horak, Charlie M.; Howell, Matthew P.; Iverson, Erik B.; Jacobs, Lorelei L.; Jones, Larry C.; Johnson, B.; Johnson, S.; Kasemir, Kay; Kim, Sang-Ho; Laughon, Gregory J.; Lu, W.; Mahoney, Kelly L.; Mammosser, John; McManamy, T.; Michilini, M.; Middendorf, Mark E.; O'Neal, Ed; Nemec, B.; Peters, Roy Cecil; Plum, Michael A.; Reagan, G.; Remec, Igor; Rennich, Mark J.; Riemer, Bernie; Saethre, Robert B.; Schubert, James Phillip; Shishlo, Andrei P.; Smith, C. Craig; Strong, William Herb; Tallant, Kathie M.; Tennant, David Alan; Thibadeau, Barbara M.; Trumble, S.; Trotter, Steven M.; Wang, Z.; Webb, Steven B.; Williams, Derrick C.; White, Karen S.; Zhao, Jinkui

    2015-01-01

    The Second Target Station (STS) is a proposed upgrade for SNS. It includes a doubling of the accelerator power and an additional instrument hall. The new instrument hall will receive a 467 kW 10 Hz beam. The parameters and preliminary design aspects of the STS are presented for the accelerator, target systems, instrument hall, instruments and civil construction aspects.

  5. Benchmarking and Evaluating Recongurable Architectures Targeting

    E-Print Network [OSTI]

    Luk, Wayne

    benchmarking suite that evaluates the power consumption of reconfigurable technology for applications targeting the mobile computing domain. This benchmark suite includes seven designs; one design targets fine-grained FPGA fabrics allowing for quick state- of-the-art evaluation, and six designs are specified at a high

  6. 100-N Area Decision Unit Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-N Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  7. CBEI - Fault Detection and Diagnostics (FDD) for Advanced RTUs...

    Broader source: Energy.gov (indexed) [DOE]

    rate of 10% performance degradation, < 1% false alarms and 3 year payback period Target MarketAudience: Market: small commercial buildings utilizing RTUs Audience: RTU...

  8. Double Spin Asymmetries of Inclusive Hadron Electroproductions from a Transversely Polarized $^3\\rm{He}$ Target

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhao, Yuxiang; et. al.,

    2015-07-01

    We report the measurement of beam-target double-spin asymmetries ($A_\\text{LT}$) in the inclusive production of identified hadrons, $\\vec{e}~$+$~^3\\text{He}^{\\uparrow}\\rightarrow h+X$, using a longitudinally polarized 5.9 GeV electron beam and a transversely polarized $^3\\rm{He}$ target. Hadrons ($\\pi^{\\pm}$, $K^{\\pm}$ and proton) were detected at 16$^{\\circ}$ with an average momentum $$=2.35 GeV/c and a transverse momentum ($p_{T}$) coverage from 0.60 to 0.68 GeV/c. Asymmetries from the $^3\\text{He}$ target were observed to be non-zero for $\\pi^{\\pm}$ production when the target was polarized transversely in the horizontal plane. The $\\pi^{+}$ and $\\pi^{-}$ asymmetries have opposite signs, analogous to the behavior of $A_\\text{LT}$ in semi-inclusive deep-inelastic scattering.

  9. Double spin asymmetries of inclusive hadron electroproductions from a transversely polarized ³He target

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhao, Yuxiang X.

    2015-07-14

    We report the measurement of beam-target double-spin asymmetries ALT in the inclusive production of identified hadrons, e +³He? ? h + X, using a longitudinally polarized 5.9 GeV electron beam and a transversely polarized ³He target. Hadrons (?±, K± and proton) were detected at 16° with an average momentum h>=2.35 GeV/c and a transverse momentum (pT) coverage from 0.60 to 0.68 GeV/c. Asymmetries from the ³He target were observed to be non-zero for ?± production when the target was polarized transversely in the horizontal plane. The ?? and ?? asymmetries have opposite signs, analogous to the behavior of ALT inmore »semi-inclusive deep-inelastic scattering.« less

  10. The analytic model of a laser-accelerated plasma target and its stability

    SciTech Connect (OSTI)

    Khudik, V. Yi, S. A.; Siemon, C.; Shvets, G.

    2014-01-15

    A self-consistent kinetic theory of a laser-accelerated plasma target with distributed electron/ion densities is developed. The simplified model assumes that after an initial transition period the bulk of cold ions are uniformly accelerated by the self-consistent electric field generated by hot electrons trapped in combined ponderomotive and electrostatic potentials. Several distinct target regions (non-neutral ion tail, non-neutral electron sheath, and neutral plasma bulk) are identified and analytically described. It is shown analytically that such laser-accelerated finite-thickness target is susceptible to Rayleigh-Taylor (RT) instability. Particle-in-cell simulations of the seeded perturbations of the plasma target reveal that, for ultra-relativistic laser intensities, the growth rate of the RT instability is depressed from the analytic estimates.

  11. Double Spin Asymmetries of Inclusive Hadron Electroproductions from a Transversely Polarized $^3\\rm{He}$ Target

    E-Print Network [OSTI]

    The Jefferson Lab Hall A Collaboration; Y. X. Zhao; K. Allada; K. Aniol; J. R. M. Annand; T. Averett; F. Benmokhtar; W. Bertozzi; P. C. Bradshaw; P. Bosted; A. Camsonne; M. Canan; G. D. Cates; C. Chen; J. -P. Chen; W. Chen; K. Chirapatpimol; E. Chudakov; E. Cisbani; J. C. Cornejo; F. Cusanno; M. Dalton; W. Deconinck; C. W. de Jager; R. De Leo; X. Deng; A. Deur; H. Ding; P. A. M. Dolph; C. Dutta; D. Dutta; L. El Fassi; S. Frullani; H. Gao; F. Garibaldi; D. Gaskell; S. Gilad; R. Gilman; O. Glamazdin; S. Golge; L. Guo; D. Hamilton; O. Hansen; D. W. Higinbotham; T. Holmstrom; J. Huang; M. Huang; H. F Ibrahim; M. Iodice; X. Jiang; G. Jin; M. K. Jones; J. Katich; A. Kelleher; W. Kim; A. Kolarkar; W. Korsch; J. J. LeRose; X. Li; Y. Li; R. Lindgren; N. Liyanage; E. Long; H. -J. Lu; D. J. Margaziotis; P. Markowitz; S. Marrone; D. McNulty; Z. -E. Meziani; R. Michaels; B. Moffit; C. Muñoz Camacho; S. Nanda; A. Narayan; V. Nelyubin; B. Norum; Y. Oh; M. Osipenko; D. Parno; J. -C. Peng; S. K. Phillips; M. Posik; A. J. R. Puckett; X. Qian; Y. Qiang; A. Rakhman; R. Ransome; S. Riordan; A. Saha; B. Sawatzky; E. Schulte; A. Shahinyan; M. H. Shabestari; S. Širca; S. Stepanyan; R. Subedi; V. Sulkosky; L. -G. Tang; W. A. Tobias; G. M. Urciuoli; I. Vilardi; K. Wang; B. Wojtsekhowski; Y. Wang; X. Yan; H. Yao; Y. Ye; Z. Ye; L. Yuan; X. Zhan; Y. Zhang; Y. -W. Zhang; B. Zhao; X. Zheng; L. Zhu; X. Zhu; X. Zong

    2015-02-04

    We report the measurement of beam-target double-spin asymmetries ($A_\\text{LT}$) in the inclusive production of identified hadrons, $\\vec{e}~$+$~^3\\text{He}^{\\uparrow}\\rightarrow h+X$, using a longitudinally polarized 5.9 GeV electron beam and a transversely polarized $^3\\rm{He}$ target. Hadrons ($\\pi^{\\pm}$, $K^{\\pm}$ and proton) were detected at 16$^{\\circ}$ with an average momentum $$=2.35 GeV/c and a transverse momentum ($p_{T}$) coverage from 0.60 to 0.68 GeV/c. Asymmetries from the $^3\\text{He}$ target were observed to be non-zero for $\\pi^{\\pm}$ production when the target was polarized transversely in the horizontal plane. The $\\pi^{+}$ and $\\pi^{-}$ asymmetries have opposite signs, analogous to the behavior of $A_\\text{LT}$ in semi-inclusive deep-inelastic scattering.

  12. Micro-fabrication Techniques for Target Components

    SciTech Connect (OSTI)

    Miles, R; Hamilton, J; Crawford, J; Ratti, S; Trevino, J; Graff, T; Stockton, C; Harvey, C

    2008-06-10

    Micro-fabrication techniques, derived from the semi-conductor industry, can be used to make a variety of useful mechanical components for targets. A selection of these components including supporting cooling arms for prototype cryogenic inertial confinement fusion targets, stepped and graded density targets for materials dynamics experiments are described. Micro-fabrication enables cost-effective, simultaneous fabrication of multiple high-precision components with complex geometries. Micro-fabrication techniques such as thin-film deposition, photo-lithographic patterning and etch processes normally used in the semi-conductor manufacture industry, can be exploited to make useful mechanical target components. Micro-fabrication processes have in recent years been used to create a number of micro-electro-mechanical systems (MEMS) components such as pressure sensors, accelerometers, ink jet printer heads, microfluidics platforms and the like. These techniques consist primarily of deposition of thin films of material, photo-lithographic patterning and etching processes performed sequentially to produce three dimensional structures using essentially planar processes. While the planar technology can be limiting in terms of the possible geometries of the final product, advantages of using these techniques include the ability to make multiple complex structures simultaneously and cost-effectively. Target components fabricated using these techniques include the supporting cooling arms for cryogenic prototype fusion ignition targets, stepped targets for equation-of-state experiments, and graded density reservoirs for material strength experiments.

  13. Protein search for multiple targets on DNA

    E-Print Network [OSTI]

    Martin Lange; Maria Kochugaeva; Anatoly B. Kolomeisky

    2015-08-03

    Protein-DNA interactions are crucial for all biological processes. One of the most important fundamental aspects of these interactions is the process of protein searching and recognizing specific binding sites on DNA. A large number of experimental and theoretical investigations have been devoted to uncovering the molecular description of these phenomena, but many aspects of the mechanisms of protein search for the targets on DNA remain not well understood. One of the most intriguing problems is the role of multiple targets in protein search dynamics. Using a recently developed theoretical framework we analyze this question in detail. Our method is based on a discrete-state stochastic approach that takes into account most relevant physical-chemical processes and leads to fully analytical description of all dynamic properties. Specifically, systems with two and three targets have been explicitly investigated. It is found that multiple targets in most cases accelerate the search in comparison with a single target situation. However, the acceleration is not always proportional to the number of targets. Surprisingly, there are even situations when it takes longer to find one of the multiple targets in comparison with the single target. It depends on the spatial position of the targets, distances between them, average scanning lengths of protein molecules on DNA, and the total DNA lengths. Physical-chemical explanations of observed results are presented. Our predictions are compared with experimental observations as well as with results from a continuum theory for the protein search. Extensive Monte Carlo computer simulations fully support our theoretical calculations.

  14. Frequency-dependent processing and interpretation (FDPI) of seismic data for identifying, imaging and monitoring fluid-saturated underground reservoirs

    DOE Patents [OSTI]

    Goloshubin, Gennady M. (Sugar Land, TX); Korneev, Valeri A. (Lafayette, CA)

    2005-09-06

    A method for identifying, imaging and monitoring dry or fluid-saturated underground reservoirs using seismic waves reflected from target porous or fractured layers is set forth. Seismic imaging the porous or fractured layer occurs by low pass filtering of the windowed reflections from the target porous or fractured layers leaving frequencies below low-most corner (or full width at half maximum) of a recorded frequency spectra. Additionally, the ratio of image amplitudes is shown to be approximately proportional to reservoir permeability, viscosity of fluid, and the fluid saturation of the porous or fractured layers.

  15. Frequency-dependent processing and interpretation (FDPI) of seismic data for identifying, imaging and monitoring fluid-saturated underground reservoirs

    DOE Patents [OSTI]

    Goloshubin, Gennady M.; Korneev, Valeri A.

    2006-11-14

    A method for identifying, imaging and monitoring dry or fluid-saturated underground reservoirs using seismic waves reflected from target porous or fractured layers is set forth. Seismic imaging the porous or fractured layer occurs by low pass filtering of the windowed reflections from the target porous or fractured layers leaving frequencies below low-most corner (or full width at half maximum) of a recorded frequency spectra. Additionally, the ratio of image amplitudes is shown to be approximately proportional to reservoir permeability, viscosity of fluid, and the fluid saturation of the porous or fractured layers.

  16. Retention of Conformational Entropy upon Calmodulin Binding to Target Peptides is Driven by Transient Salt Bridges

    SciTech Connect (OSTI)

    Smith, Dayle MA; Straatsma, TP; Squier, Thomas C.

    2012-10-03

    Calmodulin (CaM) is a highly flexible calcium-binding protein that mediates signal transduction through an ability to differentially bind to highly variable binding sequences in target proteins. To identify how binding affects CaM motions, and its relationship to conformational entropy and target peptide sequence, we have employed fully atomistic, explicit solvent molecular dynamics simulations of unbound CaM and CaM bound to five different target peptides. The calculated CaM conformational binding entropies correlate with experimentally derived conformational entropies with a correlation coefficient R2 of 0.95. Selected side-chain interactions with target peptides restrain interhelical loop motions, acting to tune the conformational entropy of the bound complex via widely distributed CaM motions. In the complex with the most conformational entropy retention (CaM in complex with the neuronal nitric oxide synthase binding sequence), Lys-148 at the C-terminus of CaM forms transient salt bridges alternating between Glu side chains in the N-domain, the central linker, and the binding target. Additional analyses of CaM structures, fluctuations, and CaM-target interactions illuminate the interplay between electrostatic, side chain, and backbone properties in the ability of CaM to recognize and discriminate against targets by tuning its conformational entropy, and suggest a need to consider conformational dynamics in optimizing binding affinities.

  17. Targeting engineering synchronization in chaotic systems

    E-Print Network [OSTI]

    Sourav K. Bhowmick; Dibakar Ghosh

    2015-06-14

    A method of targeting engineering synchronization states in two identical and mismatch chaotic systems is explained in details. The method is proposed using linear feedback controller coupling for engineering synchronization such as mixed synchronization, linear and nonlinear generalized synchronization and targeting fixed point. The general form of coupling design to target any desire synchronization state under unidirectional coupling with the help of Lyapunov function stability theory is derived analytically. A scaling factor is introduced in the coupling definition to smooth control without any loss of synchrony. Numerical results are done on two mismatch Lorenz systems and two identical Sprott oscillators.

  18. Diagnostics for High Power Targets and Dumps

    E-Print Network [OSTI]

    Gschwendtner, E

    2012-01-01

    High power targets are generally used for neutrino, antiproton, neutron and secondary beam production whereas dumps are needed in beam waste management. In order to guarantee an optimized and safe use of these targets and dumps, reliable instrumentation is needed; the diagnostics in high power beams around targets and dumps is reviewed. The suite of beam diagnostics devices used in such extreme environments is discussed, including their role in commissioning and operation. The handling and maintenance of the instrumentation components in high radiation areas is also addressed.

  19. Self-assessing target with automatic feedback

    DOE Patents [OSTI]

    Larkin, Stephen W.; Kramer, Robert L.

    2004-03-02

    A self assessing target with four quadrants and a method of use thereof. Each quadrant containing possible causes for why shots are going into that particular quadrant rather than the center mass of the target. Each possible cause is followed by a solution intended to help the marksman correct the problem causing the marksman to shoot in that particular area. In addition, the self assessing target contains possible causes for general shooting errors and solutions to the causes of the general shooting error. The automatic feedback with instant suggestions and corrections enables the shooter to improve their marksmanship.

  20. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  1. Politicians, the media, and domestic audience costs

    E-Print Network [OSTI]

    Slantchev, Branislav L

    2006-01-01

    would get at most V B À boV B , so continuation is notwould get at most V B À boV B , so continuation is not

  2. Property:Audience | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsourceII JumpQuarterly SmartDB-2,Information PromotingProperty Edit

  3. Nanotechnology-mediated targeting of tumor angiogenesis

    E-Print Network [OSTI]

    Banerjee, Deboshri

    Abstract Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology ...

  4. Webinar: Targeted Algal Biofuels and Bioproducts FOA

    Broader source: Energy.gov [DOE]

    The Energy Department’s Bioenergy Technologies Office will present a live informational webcast on the Targeted Algal Biomass and Bioproducts Funding Opportunity (DE-FOA-0001162) on October 8, 2014...

  5. Tagging and Targeting of Energy Efficiency Subsidies

    E-Print Network [OSTI]

    Allcott, Hunt

    A corrective tax or subsidy is "well-targeted" if it primarily affects choices that are more distorted by market failures. Energy efficiency subsidies are designed to correct multiple distortions: externalities, credit ...

  6. Statistical Modeling of Single Target Cell Encapsulation

    E-Print Network [OSTI]

    Moon, SangJun

    High throughput drop-on-demand systems for separation and encapsulation of individual target cells from heterogeneous mixtures of multiple cell types is an emerging method in biotechnology that has broad applications in ...

  7. Improved Gene Targeting through Cell Cycle Synchronization

    E-Print Network [OSTI]

    Tsakraklides, Vasiliki

    Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of ...

  8. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  9. Analysis of Climate Policy Targets under Uncertainty

    E-Print Network [OSTI]

    Jacoby, Henry D.

    Although policymaking in response to the climate change is essentially a challenge of risk management, most studies of the relation of emissions targets to desired climate outcomes are either deterministic or subject to a ...

  10. Improving Targeted Radionuclide Therapy Using Nuclear Nanotechnology 

    E-Print Network [OSTI]

    Evans, Jordan Andrew

    2013-05-03

    The objectives of this thesis are to produce radioactive antibody-conjugated gold nanoparticles to improve the efficacy of targeted radionuclide therapy for the treatment of cancer, and to demonstrate that this product can be produced at Texas A...

  11. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, James T. (Los Alamos, NM); Miller, John R. (Penfield, NY)

    1984-01-01

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers.

  12. Method and apparatus for producing cryogenic targets

    DOE Patents [OSTI]

    Murphy, J.T.; Miller, J.R.

    1984-08-07

    An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers. 6 figs.

  13. Cryostat including heater to heat a target

    DOE Patents [OSTI]

    Pehl, R.H.; Madden, N.W.; Malone, D.F.

    1990-09-11

    A cryostat is provided which comprises a vacuum vessel; a target disposed within the vacuum vessel; a heat sink disposed within the vacuum vessel for absorbing heat from the detector; a cooling mechanism for cooling the heat sink; a cryoabsorption mechanism for cryoabsorbing residual gas within the vacuum vessel; and a heater for maintaining the target above a temperature at which the residual gas is cryoabsorbed in the course of cryoabsorption of the residual gas by the cryoabsorption mechanism. 2 figs.

  14. Current status of the liquid lithium target

    E-Print Network [OSTI]

    McDonald, Kirk

    in target (mm) 252 x 125Maximum beam current (mA) ~1~10~100Beam spot on the target (cm2) >2 (peak)0.52.5Beam Water direction #12;15 Be Trap Heat Exchanger Cross Section Design to remove ~12 kW Lithium tank #12;Oil cycle Flexible tubes Oil pump Heat exchanger Oil chamber Inside the lab Outside the lab #12;Elect

  15. Identifying protein-protein interactions of a cell cycle regulator 

    E-Print Network [OSTI]

    Amos, Joseph Edward

    2013-02-22

    The role of anachronism (ana) protein in stem cell division of Drosophila melanogaster was examined. Synthesis of identifiable ana protein was necessary. The identifying method exploited was that of antibody tagging using ...

  16. Can the investigator identify the Does my stem cell research

    E-Print Network [OSTI]

    Emmons, Scott

    Can the investigator identify the donors? Does my stem cell research require ESCRO review? Are only (previously derived)? YES NO Can the investigator identify the donors? Does my stem cell research require CCI

  17. Identifying Infill Locations and Underperformer Wells in Mature Fields using

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    field. Identify opportunities in mature fields: Sweet spots for infill drilling. Underperformer wellsIdentifying Infill Locations and Underperformer Wells in Mature Fields using Monthly Production wells rather than the entire field. #12;Introduction Objective Methodology Results Conclusion Objective

  18. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Efficient laser-induced 6 - 8 keV x-ray production from iron oxide aerogel and foil-lined cavity targets","Perez, F; Kay, J J; Patterson, R; Kane, J; Villette, B; Girard, F;...

  19. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Research and Development of Non-Spectroscopic MEMS-Based Sensor Arrays for Targeted Gas Detection","Loui, A; McCall, S K","2011-10-24T04:00:00Z",1035279,"10.2172...

  20. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    liquid hydrogen isotopes inside a spherical-shell directly driven inertial confinement fusion target","Kim, K.; Mok, L.S.","1984-05-01T04:00:00Z",6101909,"10.2172...

  1. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Development of aerogel-lined targets for inertial confinement fusion experiments","Braun, T","2013-03-05T05:00:00Z",1077169,"10.21721077169","LLNL-TH-631353","W-7405-ENG-48",,"The...

  2. Fast ignition of inertial confinement fusion targets

    SciTech Connect (OSTI)

    Gus'kov, S. Yu., E-mail: guskov@sci.lebedev.ru [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation)

    2013-01-15

    Results of studies on fast ignition of inertial confinement fusion (ICF) targets are reviewed. The aspects of the fast ignition concept, which consists in the separation of the processes of target ignition and compression due to the synchronized action of different energy drivers, are considered. Criteria for the compression ratio and heating rate of a fast ignition target, the energy balance, and the thermonuclear gain are discussed. The results of experimental and theoretical studies of the heating of a compressed target by various types of igniting drivers, namely, beams of fast electrons and light ions produced under the action of a petawatt laser pulse on the target, a heavy-ion beam generated in the accelerator, an X-ray pulse, and a hydrodynamic flow of laser-accelerated matter, are analyzed. Requirements to the igniting-driver parameters that depend on the fast ignition criteria under the conditions of specific target heating mechanisms, as well as possibilities of practical implementation of these requirements, are discussed. The experimental programs of various laboratories and the prospects of practical implementation of fast ignition of ICF targets are reviewed. To date, fast ignition is the most promising method for decreasing the ignition energy and increasing the thermonuclear gain of an ICF plasma. A large number of publications have been devoted to investigations of this method and adjacent problems of the physics of igniting drivers and their interaction with plasma. This review presents results of only some of these studies that, in the author's opinion, allow one to discuss in detail the main physical aspects of the fast ignition concept and understand the current state and prospects of studies in this direction.

  3. ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines

    SciTech Connect (OSTI)

    Zask, Arie; Verheijen, Jeroen C.; Curran, Kevin; Kaplan, Joshua; Richard, David J.; Nowak, Pawel; Malwitz, David J.; Brooijmans, Natasja; Bard, Joel; Svenson, Kristine; Lucas, Judy; Toral-Barza, Lourdes; Zhang, Wei-Guo; Hollander, Irwin; Gibbons, James J.; Abraham, Robert T.; Ayral-Kaloustian, Semiramis; Mansour, Tarek S.; Yu, Ker

    2009-09-18

    The mammalian target of rapamycin (mTOR), a central regulator of growth, survival, and metabolism, is a validated target for cancer therapy. Rapamycin and its analogues, allosteric inhibitors of mTOR, only partially inhibit one mTOR protein complex. ATP-competitive, global inhibitors of mTOR that have the potential for enhanced anticancer efficacy are described. Structural features leading to potency and selectivity were identified and refined leading to compounds with in vivo efficacy in tumor xenograft models.

  4. Neutronic Characterization of the Megapie Target

    E-Print Network [OSTI]

    Stefano Panebianco; Olivier Bringer; Pavel Bokov; Sebastien Chabod; Frederic Chartier; Emmeric Dupont; Diane Dore; Xavier Ledoux; Alain Letourneau; Ludovic Oriol; Aurelien Prevost; Danas Ridikas; Jean-Christian Toussaint

    2007-10-31

    The MEGAPIE project is one of the key experiments towards the feasibility of Accelerator Driven Systems. On-line operation and post-irradiation analysis will provide the scientific community with unique data on the behavior of a liquid spallation target under realistic irradiation conditions. A good neutronics performance of such a target is of primary importance towards an intense neutron source, where an extended liquid metal loop requires some dedicated verifications related to the delayed neutron activity of the irradiated PbBi. In this paper we report on the experimental characterization of the MEGAPIE neutronics in terms of the prompt neutron (PN) flux inside the target and the delayed neutron (DN) flux on the top of it. For the PN measurements, a complex detector, made of 8 microscopic fission chambers, has been built and installed in the central part of the target to measure the absolute neutron flux and its spatial distribution. Moreover, integral information on the neutron energy distribution as a function of the position along the beam axis could be extracted, providing integral constraints on the neutron production models implemented in transport codes such as MCNPX. For the DN measurement, we used a standard 3He counter and we acquired data during the start-up phase of the target irradiation in order to take sufficient statistics at variable beam power. Experimental results obtained on the PN flux characteristics and their comparison with MCNPX simulations are presented, together with a preliminary analysis of the DN decay time spectrum.

  5. Divertor target for magnetic containment device

    DOE Patents [OSTI]

    Luzzi, Jr., Theodore E. (Garden City, NY)

    1982-01-01

    In a plasma containment device of a type having superconducting field coils for magnetically shaping the plasma into approximately the form of a torus, an improved divertor target for removing impurities from a "scrape off" region of the plasma comprises an array of water cooled swirl tubes onto which the scrape off flux is impinged. Impurities reflected from the divertor target are removed from the target region by a conventional vacuum getter system. The swirl tubes are oriented and spaced apart within the divertor region relative to the incident angle of the scrape off flux to cause only one side of each tube to be exposed to the flux to increase the burnout rating of the target. The divertor target plane is oriented relative to the plane of the path of the scrape off flux such that the maximum heat flux onto a swirl tube is less than the tube design flux. The containment device is used to contain the plasma of a tokamak fusion reactor and is applicable to other long pulse plasma containment systems.

  6. Magnetized target fusion and fusion propulsion.

    SciTech Connect (OSTI)

    Kirkpatrick, R. C. (Ronald C.)

    2001-01-01

    Magnetized target fusion (MTF) is a thermonuclear fusion concept that is intermediate between the two mainline approaches, magnetic confinement and inertial confinement fusion (MCF and ICF). MTF incorporates some aspects of each and offers advantages over each of the mainline approaches. First, it provides a means of reducing the driver power requirements, thereby admitting a wider range of drivers than ICF. Second, the magnetic field is only used for insulation, not confinement, and the plasma is wall confined, so that plasma instabilities are traded in for hydrodynamic instabilities. However, the degree of compression required to reach fusion conditions is lower than for ICF, so that hydrodynamic instabilities are much less threatening. The standoff driver innovation proposes to dynamically form the target plasma and a gaseous shell that compresses and confines the target plasma. Therefore, fusion target fabrication is traded in for a multiplicity of plasma guns, which must work in synchrony. The standoff driver embodiment of MTF leads to a fusion propulsion system concept that is potentially compact and lightweight. We will discuss the underlying physics of MTF and some of the details of the fusion propulsion concept using the standoff driver approach. We discuss here the optimization of an MTF target design for space propulsion.

  7. Targeted Energy Transfer Phenomena in Vibro-Impact Oscillators

    SciTech Connect (OSTI)

    Lee, Young S.; McFarland, D. Michael; Bergman, Lawrence A. [Department of Aerospace Engineering, University of Illinois at Urbana-Champaign Urbana, IL 61801 (United States); Nucera, Francesco [Department of Mechanics and Materials, Mediterranean University of Reggio Calabria 89122 Reggio Calabria (Italy); Vakakis, Alexander F. [School of Applied Mathematical and Physical Sciences, National Technical University of Athens, P.O. Box 64042, GR-15710 Zografos, Athens (Greece); Departments of Mechanical Science and Engineering, and of Aerospace Engineering (adjunct), University of Illinois at Urbana-Champaign, Urbana, IL 61801 (United States)

    2008-07-08

    We study targeted energy transfer (TET) in a coupled oscillator, consisting of a single-degree-of-freedom primary linear oscillator coupled to a vibro-impact nonlinear energy sink (VI NES). For this purpose, we first compute the VI periodic orbits of the underlying hamiltonian VI system, and construct the corresponding frequency-energy plot (FEP). Then, considering inelastic impacts and viscous dissipation, we examine VI damped transitions on the FEP to identify a TET phenomenon by exciting a VI impulsive orbit, which is the most efficient mechanism for TET. Not only can the VI TET involve passive absorption and local dissipation of significant portions of the energy from the primary systems, but it occurs at sufficiently fast time scales. This renders VI NESs suitable for applications, like seismic mitigation, where shock elimination in the early, highly energetic regime of the motion is a critical requirement.

  8. Scaling Up Renewable Energy Generation: Aligning Targets and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UP RENEWABLE ENERGY GENERATION: ALIGNING TARGETS AND INCENTIVES WITH GRID INTEGRATION CONSIDERATIONS GREENING THE GRID CASE STUDY: ITERATIVE TARGET- SETTING AND INTEGRATION STUDIES...

  9. Introducing the target-matrix paradigm for mesh optimization...

    Office of Scientific and Technical Information (OSTI)

    Conference: Introducing the target-matrix paradigm for mesh optimization via node-movement. Citation Details In-Document Search Title: Introducing the target-matrix paradigm for...

  10. Introducing the Target-Matrix Paradigm for Mesh Optimization...

    Office of Scientific and Technical Information (OSTI)

    Introducing the Target-Matrix Paradigm for Mesh Optimization via Node-movement. Citation Details In-Document Search Title: Introducing the Target-Matrix Paradigm for Mesh...

  11. EPA-GHG Inventory Targeted Data Collection Strategies and Software...

    Open Energy Info (EERE)

    EPA-GHG Inventory Targeted Data Collection Strategies and Software Tools (Redirected from US EPA GHG Inventory Targeted Data Collection Strategies and Software Tools) Jump to:...

  12. Mutations and genetic targets for enhanced L-tyrosine production...

    Office of Scientific and Technical Information (OSTI)

    Search Title: Mutations and genetic targets for enhanced L-tyrosine production The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine...

  13. Physics Opportunities of a Fixed-Target Experiment using the...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Physics Opportunities of a Fixed-Target Experiment using the LHC Beams Citation Details In-Document Search Title: Physics Opportunities of a Fixed-Target...

  14. EV Everywhere Consumer/Charging Workshop: Target-Setting Framework...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ConsumerCharging Workshop: Target-Setting Framework and Consumer Behavior EV Everywhere ConsumerCharging Workshop: Target-Setting Framework and Consumer Behavior Presentation...

  15. EV Everywhere Battery Workshop: Preliminary Target-Setting Framework...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Publications EV Everywhere Electric Drive Workshop: Preliminary Target-Setting Framework EV Everywhere ConsumerCharging Workshop: Target-Setting Framework and Consumer Behavior...

  16. Enterprise Assessments Targeted Review of the Safety-Significant...

    Energy Savers [EERE]

    Targeted Review of the Safety-Significant Systems at the Pacific Northwest National Laboratory Radiochemical Processing Laboratory - July 2015 Enterprise Assessments Targeted...

  17. Independent Oversight Targeted Review, Y-12 National Security...

    Energy Savers [EERE]

    Independent Oversight Targeted Review, Y-12 National Security Complex - February 2012 Independent Oversight Targeted Review, Y-12 National Security Complex - February 2012 February...

  18. Enterprise Assessments Targeted Review, Work Planning and Control...

    Energy Savers [EERE]

    and Control at the Hanford Tank Farms - April 2015 Enterprise Assessments Targeted Review, Work Planning and Control at the Hanford Tank Farms - April 2015 April 2015 Targeted...

  19. Combustion Targets for Low Emissions and High Efficiency | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Targets for Low Emissions and High Efficiency Combustion Targets for Low Emissions and High Efficiency 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and...

  20. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Wednesday, 03 December 2014 00:00 Immortality is...

  1. Enterprise Assessments Targeted Review,Y-12 National Security...

    Office of Environmental Management (EM)

    Y-12 National Security Complex - March 2015 Enterprise Assessments Targeted Review,Y-12 National Security Complex - March 2015 March 2015 Targeted Review of Work Planning and...

  2. DOE Hydrogen Storage Technical Performance Targets for Light...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Light-Duty Vehicles DOE Hydrogen Storage Technical Performance Targets for Light-Duty Vehicles This table summarizes technical performance targets for hydrogen storage systems...

  3. DOE Hydrogen Storage Technical Performance Targets for Material...

    Broader source: Energy.gov (indexed) [DOE]

    This table summarizes hydrogen storage technical performance targets for material handling equipment. These targets were developed with input to DOE through extensive...

  4. Target Explanation Document: Onboard Hydrogen Storage for Light...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Target Explanation Document: Onboard Hydrogen Storage for Light-Duty Fuel Cell Vehicles Target Explanation Document: Onboard Hydrogen Storage for Light-Duty Fuel Cell Vehicles This...

  5. DOE Hydrogen Storage Technical Performance Targets for Portable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Portable Power Applications DOE Hydrogen Storage Technical Performance Targets for Portable Power Applications These tables summarize hydrogen storage technical performance targets...

  6. Bio-Derived Liquids to Hydrogen Distributed Reforming Targets...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Targets (Presentation) Bio-Derived Liquids to Hydrogen Distributed Reforming Targets (Presentation) Presented at the 2007 Bio-Derived Liquids to Hydrogen Distributed Reforming...

  7. Environmental Management System (EMS) objectives & targets : annual results summary %3CU%2B2013%3E FY10.

    SciTech Connect (OSTI)

    Waffelaert, Pascale S.; Vetter, Douglas Walter

    2011-05-01

    Sandia National Laboratory/New Mexico's (SNL/NM) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each fiscal year (FY) significant environmental aspects are identified and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are designed to mitigate the impact of SNL/NM's operations on the environment. An annual summary of the results achieved towards meeting established objectives and targets provides a connection to and rational for annually revised significant aspects. The purpose of this document is to summarize the results achieved and documented in FY2010.

  8. Neutron single target spin asymmetries in SIDIS

    SciTech Connect (OSTI)

    Evaristo Cisbani

    2010-04-01

    The experiment E06-010 in Hall A at Jefferson Lab took data between November 2008 and February 2009 to directly measure, for the first time, the pion (and kaon) single "neutron" target-spin asymmetry (SSA) in semi-inclusive DIS from a polarized 3He target. Collins, Sivers (and Pretzelosity) neutron asymmetries are going to be extracted from the measured SSA. Details of the experiment are described together with the preliminary results of the ongoing analysis. Near future Hall A experiments on transverse nucleon spin structure are shorty reviewed.

  9. Prototyping of the ILC Baseline Positron Target

    SciTech Connect (OSTI)

    Gronberg, J; Brooksby, C; Piggott, T; Abbott, R; Javedani, J; Cook, E

    2012-02-29

    The ILC positron system uses novel helical undulators to create a powerful photon beam from the main electron beam. This beam is passed through a titanium target to convert it into electron-positron pairs. The target is constructed as a 1 m diameter wheel spinning at 2000 RPM to smear the 1 ms ILC pulse train over 10 cm. A pulsed flux concentrating magnet is used to increase the positron capture efficiency. It is cooled to liquid nitrogen temperatures to maximize the flatness of the magnetic field over the 1 ms ILC pulse train. We report on prototyping effort on this system.

  10. Prototyping of the ILC Baseline Positron Target

    E-Print Network [OSTI]

    Gronberg, Jeff; Piggott, Tom; Abbott, Ryan; Javedani, Jay; Cook, Ed

    2012-01-01

    The ILC positron system uses novel helical undulators to create a powerful photon beam from the main electron beam. This beam is passed through a titanium target to convert it into electron-positron pairs. The target is constructed as a 1 m diameter wheel spinning at 2000 RPM to smear the 1 ms ILC pulse train over 10 cm. A pulsed flux concentrating magnet is used to increase the positron capture efficiency. It is cooled to liquid nitrogen temperatures to maximize the flatness of the magnetic field over the 1 ms ILC pulse train. We report on prototyping effort on this system.

  11. Linear and angular retroreflecting interferometric alignment target

    DOE Patents [OSTI]

    Maxey, L. Curtis (Powell, TN)

    2001-01-01

    The present invention provides a method and apparatus for measuring both the linear displacement and angular displacement of an object using a linear interferometer system and an optical target comprising a lens, a reflective surface and a retroreflector. The lens, reflecting surface and retroreflector are specifically aligned and fixed in optical connection with one another, creating a single optical target which moves as a unit that provides multi-axis displacement information for the object with which it is associated. This displacement information is useful in many applications including machine tool control systems and laser tracker systems, among others.

  12. ALT-3 Target & CMU Version 4

    SciTech Connect (OSTI)

    Griego, Jeffrey R; Atchison, Walter L.; Holtkamp, David; Oro, David M.; Reinovsky, Robert E.; Rousculp, Christopher L.; Tabaka, Leonard J.

    2012-06-11

    The third Advance Liner Technology (ALT-3) experiment is the next in a long tradition of collaborations between LANL and RFNC/VNIIEF in high-explosive pulsed-power. Here a VNIIEF provided Disk Explosive Magnetic Generator (DEMG) will drive a LANL provided experimental load and diagnostic package. The objective of the experiment is to explore the use of a cylindrical liner-ontarget in tera-Pascal equation of state measurement. This presentation will discuss version 4 of the experimental target and central measuring unit (CMU) along with R & D already performed in fabrication of the target.

  13. Insights from Smart Meters: Identifying Specific Actions, Behaviors...

    Energy Savers [EERE]

    and Characteristics That Drive Savings in Behavior-Based Programs Insights from Smart Meters: Identifying Specific Actions, Behaviors, and Characteristics That Drive...

  14. Identify Institutional Change Rules, Roles, and Tools Constituting...

    Broader source: Energy.gov (indexed) [DOE]

    goals are to be achieved. Start by identifying the organizational rules, roles, and tools that shape the current context and may influence success in achieving these goals....

  15. Low Bias Electron Scattering in Structure-Identified Single Wall...

    Office of Scientific and Technical Information (OSTI)

    Date: 2011-09-01 OSTI Identifier: 1100843 Type: Publisher's Accepted Manuscript Journal Name: Physical Review Letters Additional Journal Information: Journal Volume: 107;...

  16. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    throughput diffusion chamber cultivation approach to isolation of novel environmental bacteria relevant to DOE missions. 2. To use the optimized method to identify and cultivate...

  17. Mapping Soil Carbon from Cradle to Grave: Identifying the Microbial...

    Office of Scientific and Technical Information (OSTI)

    Conference: Mapping Soil Carbon from Cradle to Grave: Identifying the Microbial Blueprint for Root-carbon Transformations in Soil Citation Details In-Document Search Title: Mapping...

  18. Mapping Soil Carbon from Cradle to Grave: Identifying the Microbial...

    Office of Scientific and Technical Information (OSTI)

    In-Document Search Title: Mapping Soil Carbon from Cradle to Grave: Identifying the Microbial Blueprint for Root-carbon Transformations in Soil Erin Nuccio, Lawrence...

  19. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    developing rapid screening methods to assess surfactant performance for IOR (Improved Oil Recovery) from fractured carbonate reservoirs. The desired outcome is to identify...

  20. ALCF supercomputer helps identify materials to improve fuel production...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF supercomputer helps identify materials to improve fuel production Author: Jim Collins . April 24, 2015 Printer-friendly version With access to supercomputing resources at the...

  1. Briefing, DOE Order 475.2B, Identifying Classified Information...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    regarding the changes to the DOE Order on Identifying Classified Information. Subjects include DC responsibilities regarding classification challenges and the process for...

  2. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    level movements with quasi-periodicity of 430,000 years are identified in the marine sedimentary units of the Eastern Gulf Coastal Plain of Mississippi, Alabama and...

  3. Radiokrypton Dating Identifies Ancient Antarctic Ice | U.S. DOE...

    Office of Science (SC) Website

    Radiokrypton Dating Identifies Ancient Antarctic Ice Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Funding Opportunities Nuclear Science...

  4. Isoform discovery by targeted cloning,`deep-

    E-Print Network [OSTI]

    Roth, Frederick

    Isoform discovery by targeted cloning,`deep- well' pooling and parallel sequencing Kourosh Salehi transcriptase (RT)- PCR recombinational cloning,`deep-well' pooling and a next- generation sequencing platform and demonstrate the ORFeome primer pairs ORFeome minipool arrays Single colony isolates `Deep wells' of pooled

  5. Autonomous Airborne Geomagnetic Surveying and Target Identification

    E-Print Network [OSTI]

    Washington at Seattle, University of

    Positioning System (GPS) technology, and sensors (video and infrared cameras, magnetometers) coupled and identification of magnetic anomalies are evaluated. A combination of a particle filter and a neural network Airspeed w Weight on particle x State of agent with respect to target z Sensor measurement Subscript t Time

  6. Autonomous Airborne Geomagnetic Surveying and Target Identification

    E-Print Network [OSTI]

    Lum, Christopher

    in miniaturized electronics, Global Positioning System (GPS) technology, and sensors (video and infrared cameras and identification of magnetic anomalies are evaluated. A combination of a particle filter and a neural network Airspeed w Weight on particle x State of agent with respect to target z Sensor measurement Subscript t Time

  7. Automated Testing with Targeted Event Sequence Generation

    E-Print Network [OSTI]

    Møller, Anders

    Engineering]: Testing and Debugging General Terms Languages, Verification Keywords Symbolic execution; test heavy but may have complex user interaction patterns. One popular technique is black-box random testingAutomated Testing with Targeted Event Sequence Generation Casper S. Jensen , Aarhus University

  8. Target Improves Efficiency in New Construction

    SciTech Connect (OSTI)

    2013-03-01

    Target Corporation partnered with the U.S. Department of Energy (DOE) to develop and implement solutions to reduce annual energy consumption in new stores by at least 50% versus requirements set by ASHRAE/ANSI/IESNA Standard 90.1-20041 as part of DOE’s Commercial Building Partnership (CBP) program.

  9. Actinide Targets for Neutron Cross Section Measurements

    SciTech Connect (OSTI)

    John D. Baker; Christopher A. McGrath

    2006-10-01

    The Advanced Fuel Cycle Initiative (AFCI) and the Generation IV Reactor Initiative have demonstrated a lack of detailed neutron cross-sections for certain "minor" actinides, those other than the most common (235U, 238U, and 239Pu). For some closed-fuel-cycle reactor designs more than 50% of reactivity will, at some point, be derived from "minor" actinides that currently have poorly known or in some cases not measured (n,?) and (n,f) cross sections. A program of measurements under AFCI has begun to correct this. One of the initial hurdles has been to produce well-characterized, highly isotopically enriched, and chemically pure actinide targets on thin backings. Using a combination of resurrected techniques and new developments, we have made a series of targets including highly enriched 239Pu, 240Pu, and 242Pu. Thus far, we have electrodeposited these actinide targets. In the future, we plan to study reductive distillation to achieve homogeneous, adherent targets on thin metal foils and polymer backings. As we move forward, separated isotopes become scarcer, and safety concerns become greater. The chemical purification and electodeposition techniques will be described.

  10. Liquid targets for isotope production Jerry Nolen

    E-Print Network [OSTI]

    McDonald, Kirk

    W E-beam-on-Target Test at ANL MCNPX : for RIA, 200-kW uranium beam on Li peak energy deposition = 2 MW/cm3 1MeV, 20 mA, 1mm e-beam on Li deposited in the first 4 mm Test Objectives: Using

  11. Investigating Visual Feedforward for Target Expansion Techniques

    E-Print Network [OSTI]

    . Three design axes characterize the concept of atomic feedforward mechanism, an elementary unit that can expansion technique. Focusing on feedforward mechanisms, we introduce a design space that allows us the concept of atomic feedforward mechanism along three design axes. We then describe a target expansion

  12. Beam Pulse Structure and Targets Roger Bennett

    E-Print Network [OSTI]

    McDonald, Kirk

    Beam Pulse Structure and Targets Roger Bennett Rutherford Appleton Laboratory, Chilton, Didcot jets Thermal shock is not a problem - provided the pulse is short enough. #12;Shock, Pulse Length that there is permanent distortion or failure - shock. Short high intensity beam pulses will give rise to shock

  13. IFE Target Fabrication, Delivery, and Cost Estimates

    E-Print Network [OSTI]

    Foam Shell Generation Seal Coat Formation CO2 Drying High-Z Sputter CoatingDT Filling DT Layering" for IFE - Large effort for NIC fosters efficiency (e.g., foam shells) 2. The recent IFE target technology (ZFE) · Foam capsule with overcoat HIF Distributed Radiator SNL Dynamic Hohlraum · Advanced

  14. Manufacturing complex silica aerogel target components

    SciTech Connect (OSTI)

    Defriend Obrey, Kimberly Ann [Los Alamos National Laboratory; Day, Robert D [Los Alamos National Laboratory; Espinoza, Brent F [Los Alamos National Laboratory; Hatch, Doug [Los Alamos National Laboratory; Patterson, Brian M [Los Alamos National Laboratory; Feng, Shihai [Los Alamos National Laboratory

    2008-01-01

    Aerogel is a material used in numerous components in High Energy Density Physics targets. In the past these components were molded into the proper shapes. Artifacts left in the parts from the molding process, such as contour irregularities from shrinkage and density gradients caused by the skin, have caused LANL to pursue machining as a way to make the components.

  15. Discovering the Targets of Drugs Via Computational

    E-Print Network [OSTI]

    Discovering the Targets of Drugs Via Computational Systems Biology* Published, JBC Papers in Press is empowering the study of drug action. Studies on biological effects of chemical com- pounds have increased of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy

  16. Adnostic: Privacy Preserving Targeted Advertising Vincent Toubiana

    E-Print Network [OSTI]

    Nissenbaum, Helen

    across web sites in order to infer user interests and preferences. These interests and preferences that OBA and privacy are inherently in conflict. In this paper we propose a practical architectureSense service will begin targeting ads based on the user's browsing behavior [4]. In the next section we survey

  17. Influence of lateral target size on hot electron production and electromagnetic pulse emission from laser-irradiated metallic targets

    SciTech Connect (OSTI)

    Chen Ziyu; Li Jianfeng; Yu Yong; Li Xiaoya; Peng Qixian; Zhu Wenjun [National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900 (China); Wang Jiaxiang [State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062 (China)

    2012-11-15

    The influences of lateral target size on hot electron production and electromagnetic pulse emission from laser interaction with metallic targets have been investigated. Particle-in-cell simulations at high laser intensities show that the yield of hot electrons tends to increase with lateral target size, because the larger surface area reduces the electrostatic field on the target, owing to its expansion along the target surface. At lower laser intensities and longer time scales, experimental data characterizing electromagnetic pulse emission as a function of lateral target size also show target-size effects. Charge separation and a larger target tending to have a lower target potential have both been observed. The increase in radiation strength and downshift in radiation frequency with increasing lateral target size can be interpreted using a simple model of the electrical capacity of the target.

  18. Environmental Management System (EMS) objectives and targets : annual results summary - FY2011.

    SciTech Connect (OSTI)

    Vetter, Douglas Walter

    2012-02-01

    Sandia National Laboratories/New Mexico's (SNL/NM) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each Fiscal Year (FY) SNL/NM performs an analysis to identify environmental aspects, and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are established to mitigate potential impacts of SNL/NM's operations on the environment. An annual summary of the results achieved towards meeting established objectives and targets provides a connection to, and rational for, annually revised environmental aspects. The purpose of this document is to summarize the results achieved and documented in FY2011.

  19. Environmental Management System (EMS) objectives&targets annual results summary : FY2012.

    SciTech Connect (OSTI)

    Vetter, Douglas Walter

    2013-02-01

    Sandia National Laboratories/New Mexico's (SNL/NM) Environmental Management System is the integrated approach for members of the workforce to identify and manage environmental risks. Each Fiscal Year (FY) SNL/NM performs an analysis to identify environmental aspects, and the environmental programs associated with them are charged with the task of routinely monitoring and measuring the objectives and targets that are established to mitigate potential impacts of SNL/NM's operations on the environment. An annual summary of the results achieved towards meeting established objectives and targets provides a connection to, and rational for, annually revised environmental aspects. The purpose of this document is to summarize the results achieved and documented in FY2012.

  20. Example Performance Targets and Efficiency Packages Greensburg, Kansas (Presentation)

    SciTech Connect (OSTI)

    Anderson, R.

    2008-01-01

    This presentation shows the energy performance targets and efficiency packages for residential buildings in Greensburg, Kansas.

  1. Energy-Efficient Target Coverage in Wireless Sensor Networks

    E-Print Network [OSTI]

    Cardei, Mihaela

    successively. Only the sensors from the current active set are responsible for monitoring all targets

  2. LIQUID METAL JET TARGETS FOR INTENSE HIGH ENERGY BEAMS

    E-Print Network [OSTI]

    McDonald, Kirk

    LIQUID METAL JET TARGETS FOR INTENSE HIGH ENERGY BEAMS G. I. Silvestrov, Budker Institute for Nuclear Physics Novosibirsk, August 1998. #12;1 LIQUID METAL JET TARGETS FOR INTENSE HIGH ENERGY BEAMS target of liquid metal. The technical solution is producing the target in the form of flat jet flowing

  3. NEWLY IDENTIFIED EXTENDED GREEN OBJECTS (EGOs) FROM THE SPITZER GLIMPSE II SURVEY. II. MOLECULAR CLOUD ENVIRONMENTS

    SciTech Connect (OSTI)

    Chen Xi; Gan Conggui; Shen Zhiqiang [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030 (China); Ellingsen, Simon P.; Titmarsh, Anita [School of Mathematics and Physics, University of Tasmania, Hobart, Tasmania (Australia); He Jinhua, E-mail: chenxi@shao.ac.cn [Key Laboratory for the Structure and Evolution of Celestial Objects, Yunnan Astronomical Observatory/National Astronomical Observatory, Chinese Academy of Sciences, P.O. Box 110, Kunming 650011, Yunnan Province (China)

    2013-06-01

    We have undertaken a survey of molecular lines in the 3 mm band toward 57 young stellar objects using the Australia Telescope National Facility Mopra 22 m radio telescope. The target sources were young stellar objects with active outflows (extended green objects (EGOs)) newly identified from the GLIMPSE II survey. We observe a high detection rate (50%) of broad line wing emission in the HNC and CS thermal lines, which combined with the high detection rate of class I methanol masers toward these sources (reported in Paper I) further demonstrates that the GLIMPSE II EGOs are associated with outflows. The physical and kinematic characteristics derived from the 3 mm molecular lines for these newly identified EGOs are consistent with these sources being massive young stellar objects with ongoing outflow activity and rapid accretion. These findings support our previous investigations of the mid-infrared properties of these sources and their association with other star formation tracers (e.g., infrared dark clouds, methanol masers and millimeter dust sources) presented in Paper I. The high detection rate (64%) of the hot core tracer CH{sub 3}CN reveals that the majority of these new EGOs have evolved to the hot molecular core stage. Comparison of the observed molecular column densities with predictions from hot core chemistry models reveals that the newly identified EGOs from the GLIMPSE II survey are members of the youngest hot core population, with an evolutionary time scale of the order of 10{sup 3} yr.

  4. Identifying Vulnerabilities and Critical Requirements Using Criminal Court Proceeding

    E-Print Network [OSTI]

    Breaux, Travis D.

    , as applied to criminal court records to identify mitigating requirements that improve privacy protectionsIdentifying Vulnerabilities and Critical Requirements Using Criminal Court Proceeding Travis D,jdlewis,pnotto,anton}@ncsu.edu ABSTRACT Information systems governed by laws and regulations are subject to civil and criminal violations

  5. Identifying Vulnerabilities and Critical Requirements Using Criminal Court Proceedings

    E-Print Network [OSTI]

    Young, R. Michael

    and goal models, as applied to criminal court records to identify mitigating requirements. In a sustainableIdentifying Vulnerabilities and Critical Requirements Using Criminal Court Proceedings Travis D,jdlewis,pnotto,anton}@ncsu.edu Abstract Information systems governed by laws and regulations are subject to both civil and criminal

  6. Use of Strontium Isotopes to Identify Buried Water Main Leakage

    E-Print Network [OSTI]

    Jiao, Jiu Jimmy

    Use of Strontium Isotopes to Identify Buried Water Main Leakage Into Groundwater in a Highly water mains. The identification of leakage locations was done by conventional water quality parameters to identify leakage locations especially where the leakage is from drinking water mains because the chemical

  7. A taxonomy for identifying requirement interactions in software systems

    E-Print Network [OSTI]

    Eberlein, Armin

    A taxonomy for identifying requirement interactions in software systems Mohamed Shehata a taxonomy for classifying and identifying requirement interactions in software systems. The proposed taxonomy is in the form of a four-layered pyramid that defines 6 Main Interaction Categories in the first

  8. Method for identifying type I diabetes mellitus in humans

    DOE Patents [OSTI]

    Metz, Thomas O [Kennewick, WA; Qian, Weijun [Richland, WA; Jacobs, Jon M [Pasco, WA

    2011-04-12

    A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.

  9. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Research and Development of Non-Spectroscopic MEMS-Based Sensor Arrays for Targeted Gas Detection","Loui, A; McCall, S K; Zumstein, J M","2012-11-21T05:00:00Z",1059450,"10.2172...

  10. Tracking moving radar targets with parallel, velocity-tuned filters

    DOE Patents [OSTI]

    Bickel, Douglas L.; Harmony, David W.; Bielek, Timothy P.; Hollowell, Jeff A.; Murray, Margaret S.; Martinez, Ana

    2013-04-30

    Radar data associated with radar illumination of a movable target is processed to monitor motion of the target. A plurality of filter operations are performed in parallel on the radar data so that each filter operation produces target image information. The filter operations are defined to have respectively corresponding velocity ranges that differ from one another. The target image information produced by one of the filter operations represents the target more accurately than the target image information produced by the remainder of the filter operations when a current velocity of the target is within the velocity range associated with the one filter operation. In response to the current velocity of the target being within the velocity range associated with the one filter operation, motion of the target is tracked based on the target image information produced by the one filter operation.

  11. Can autistic traits present in the normal population determine social communication abilities? An investigation into correlations between AQ score and performance in communication tasks testing audience design and lexical alignment. 

    E-Print Network [OSTI]

    Baring, Rosalind M B

    2009-07-03

    This study explored the concept of the Autistic Spectrum (Wing (1988)), and the theory that autistic traits of varying severity can be identified and measured in the general population using Baron-Cohen, Wheelwright, ...

  12. Hazard Labeling Elements 1. Product identifier: how the hazardous chemical is identified. This can be (but is not

    E-Print Network [OSTI]

    Chapman, Michael S.

    Hazard Labeling Elements 1. Product identifier: how the hazardous chemical is identified. This can of severity of hazard and alert the reader to a potential hazard on the label. There are only two signal words, "Danger" and "Warning." Within a specific hazard class, "Danger" is used for the more severe hazards

  13. Fabrication of a 238Pu target

    SciTech Connect (OSTI)

    Wu, C Y; Chyzh, A; Kwan, E; Henderson, R; Gostic, J; Carter, D

    2010-11-16

    Precision neutron-induced reaction data are important for modeling the network of isotope production and destruction within a given diagnostic chain. This network modeling has many applications such as the design of advanced fuel cycle for reactors and the interpretation of radiochemical data related to the stockpile stewardship and nuclear forensics projects. Our current funded effort is to improve the neutron-induced reaction data on the short-lived actinides and the specific goal is to improve the neutron capture data on {sup 238}Pu with a half-life of 87.7 years. In this report, the fabrication of a {sup 238}Pu target for the proposed measurement using the DANCE array at LANL is described. The {sup 238}Pu target was fabricated from a sample enriched to 99.35%, acquired from ORNL. A total of 395 {micro}g was electroplated onto both sides of a 3 {micro}m thick Ti foil using a custom-made plating cell, shown in Fig 1. The target-material loaded Ti foil is sandwiched between two double-side aluminized mylar foils with a thickness of 1.4 {micro}m. The mylar foil is glued to a polyimide ring. This arrangement is shown partially in Fig. 2. The assembled target is then inserted into an aluminum container with a wall thickness of 0.76 mm, shown in Fig. 3. A derlin ring is used to keep the target assembly in place. The ends of this cylindrical container are vacuum-sealed by two covers with thin Kapton foils as windows for the beam entrance and exit. Shown in Fig. 4 is details of the arrangement. This target is used for phase I of the proposed measurement on {sup 238}Pu scheduled for Nov 2010 together with the DANCE array to address the safety issues raised by LANL. Shown in Fig. 5 is the preliminary results on the yield spectrum as a function of neutron incident energy with a gate on the total {gamma}-ray energy of equivalent Q value. Since no fission PPAC is employed, the distinction between the capture and fission events cannot be made, which is important for the higher neutron incident energy. However, it indicates that a cross section of less than one barn can be measured. The second phase of this experiment will be carried out in 2011 by assembling a PPAC with the {sup 238}Pu target to extend the measurement to higher neutron incident energies by distinguishing the capture from fission events. The fission cross section becomes dominant for neutron incident energies above 30 keV. This PPAC was developed in FY2010 under the NA22 funding and performed very well for the {sup 239}Pu and {sup 241}Pu measurements. A new {sup 238}Pu target will be fabricated for the phase II measurement using the same electroplating technique.

  14. Fixed target experiments at the Fermilab Tevatron

    SciTech Connect (OSTI)

    Gutierrez, Gaston; Reyes, Marco A.

    2014-09-29

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of ?s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include ????, K?s K?s, K?s K±??, ?? and D. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D.

  15. STARS MDT-II targets mission

    SciTech Connect (OSTI)

    Sims, B.A.; White, J.E.

    1997-08-01

    The Strategic Target System (STARS) was launched successfully on August 31, 1996 from the Kauai Test Facility (KTF) at the Pacific Missile Range Facility (PMRF). The STARS II booster delivered a payload complement of 26 vehicles atop a post boost vehicle. These targets were designed and the mission planning was achieved to provide for a dedicated mission for view by the Midcourse Space Experiment (MSX) Satellite Sensor Suite. Along with the MSX Satellite, other corollary sensors were involved. Included in these were the Airborne Surveillance Test Bed (AST) aircraft, the Cobra Judy sea based radar platform, Kwajalein Missile Range (KMR), and the Kiernan Reentry Measurements Site (KREMS). The launch was a huge success from all aspects. The STARS Booster flew a perfect mission from hardware, software and mission planning respects. The payload complement achieved its desired goals. All sensors (space, air, ship, and ground) attained excellent coverage and data recording.

  16. Magnetized Target Fusion Collaboration. Final report

    SciTech Connect (OSTI)

    John Slough

    2012-04-18

    Nuclear fusion has the potential to satisfy the prodigious power that the world will demand in the future, but it has yet to be harnessed as a practical energy source. The entry of fusion as a viable, competitive source of power has been stymied by the challenge of finding an economical way to provide for the confinement and heating of the plasma fuel. It is the contention here that a simpler path to fusion can be achieved by creating fusion conditions in a different regime at small scale (~ a few cm). One such program now under study, referred to as Magnetized Target Fusion (MTF), is directed at obtaining fusion in this high energy density regime by rapidly compressing a compact toroidal plasmoid commonly referred to as a Field Reversed Configuration (FRC). To make fusion practical at this smaller scale, an efficient method for compressing the FRC to fusion gain conditions is required. In one variant of MTF a conducting metal shell is imploded electrically. This radially compresses and heats the FRC plasmoid to fusion conditions. The closed magnetic field in the target plasmoid suppresses the thermal transport to the confining shell, thus lowering the imploding power needed to compress the target. The undertaking described in this report was to provide a suitable target FRC, as well as a simple and robust method for inserting and stopping the FRC within the imploding liner. The FRC must also survive during the time it takes for the metal liner to compress the FRC target. The initial work at the UW was focused on developing adequate preionization and flux trapping that were found to be essential in past experiments for obtaining the density, flux and most critically, FRC lifetime required for MTF. The timescale for testing and development of such a source can be rapidly accelerated by taking advantage of a new facility funded by the Department of Energy. At this facility, two inductive plasma accelerators (IPA) were constructed and tested. Recent experiments with these IPAs have demonstrated the ability to rapidly form, accelerate and merge two hypervelocity FRCs into a compression chamber. The resultant FRC that was formed was hot (T{sub ion} ~ 400 eV), stationary, and stable with a configuration lifetime several times that necessary for the MTF liner experiments. The accelerator length was less than 1 meter, and the time from the initiation of formation to the establishment of the final equilibrium was less than 10 microseconds. With some modification, each accelerator can be made capable of producing FRCs suitable for the production of the target plasma for the MTF liner experiment. Based on the initial FRC merging/compression results, the design and methodology for an experimental realization of the target plasma for the MTF liner experiment can now be defined. The construction and testing of the key components for the formation of the target plasma at the Air Force Research Laboratory (AFRL) will be performed on the IPA experiment, now at MSNW. A high density FRC plasmoid will be formed and accelerated out of each IPA into a merging/compression chamber similar to the imploding liner at AFRL. The properties of the resultant FRC plasma (size, temperature, density, flux, lifetime) will be obtained. The process will be optimized, and a final design for implementation at AFRL will be carried out. When implemented at AFRL it is anticipated that the colliding/merging FRCs will then be compressed by the liner. In this manner it is hoped that ultimately a plasma with ion temperatures reaching the 10 keV range and fusion gain near unity can be obtained.

  17. Target Diagnostics Supports NIF's Path to Ignition

    SciTech Connect (OSTI)

    Shelton, R

    2011-12-07

    The physics requirements derived from the National Ignition Facility (NIF) experimental campaigns are leading to a wide variety of target diagnostics. Software development for the control and analysis of these diagnostics is included in the NIF Integrated Computer Control System, Diagnostic Control System and Data Visualization. These projects implement the configuration, controls, data analysis and visual representation of most of these diagnostics. To date, over 40 target diagnostics have been developed to support NIF experiments. In 2011 diagnostics were developed or enhanced to measure Ignition performance in a high neutron yield environment. Performance is optimized around four key variables: Adiabat (a) which is the strength and timing of four shocks delivered to the target, Velocity (V) of the imploding target, Mix (M) is the uniformity of the burn, and the Shape (S) of the imploding Deuterium Tritium (DT) hot spot. The diagnostics used to measure each of these parameters is shown in figure 1. Adiabat is measured using the Velocity Interferometer System for Any Reflector (VISAR) diagnostic consisting of three streak cameras. To provide for more accurate adiabat measurements the VISAR streak cameras were enhanced in FY11 with a ten comb fiducial signal controller to allow for post shot correction of the streak camera sweep non-linearity. Mix is measured by the Neutron Time of Flight (NTOF) and Radiochemical Analysis of Gaseous Samples (RAGS) diagnostics. To accommodate high neutron yield shots, NTOF diagnostic controls are being modified to use Mach Zehnder interferometer signals to allow the digitizers to be moved from near the target chamber to the neutron shielded diagnostic mezzanine. In December 2011 the first phase of RAGS diagnostic commissioning will be completed. This diagnostic will analyze the tracers that are added to NIF target capsules that undergo nuclear reactions during the shot. These gases are collected and purified for nuclear counting by the RAGS system. Three new instrument controllers were developed and commissioned to support this diagnostic. A residual-gas analyzer (RGA) instrument measures the gas content at various points in the system. The Digital Gamma Spectrometer instrument measures the radiological spectrum of the decaying gas isotopes. A final instrument controller was developed to interface to a PLC based Gas collection system. In order to support the implosion velocity measurements an additional Gated X-ray Detector (GXD) diagnostic was tested and commissioned. This third GXD views the target through a slit contained in its snout and allows the other GXD diagnostics to be used for measuring the shape on the same shot. In order to measure the implosion shape in a high neutron environment, Actide Readout In A Neutron Environment (ARIANE) and Neutron Imaging (NI) diagnostics were commissioned. The controls for ARIANE, a fixed port gated x-ray imager, contain a neutron shielded camera and micro channel plate pulser with its neutron sensitive electronics located in the diagnostic mezzanine. The NI diagnostic is composed of two Spectral Instruments SI-1000 cameras located 20M from the target and provides neutron images of the DT hot spot for high yield shots. The development and commissioning of these new or enhanced diagnostics in FY11 have provided meaningful insight that facilitates the optimization of the four key Ignition variables. In FY12 they will be adding three new diagnostics and enhancing four existing diagnostics in support of the continuing optimization series of campaigns.

  18. Recovery of niobium from irradiated targets

    DOE Patents [OSTI]

    Phillips, Dennis R. (Los Alamos, NM); Jamriska, Sr., David J. (Los Alamos, NM); Hamilton, Virginia T. (Los Alamos, NM)

    1994-01-01

    A process for selective separation of niobium from proton irradiated molybdenum targets is provided and includes dissolving the molybdenum target in a hydrogen peroxide solution to form a first ion-containing solution, contacting the first ion-containing solution with a cationic resin whereby ions selected form the group consisting of molybdenum, biobium, technetium, selenium, vanadium, arsenic, germanium, zirconium and rubidium remain in a second ion-containing solution while ions selected from the group consisting of rubidium, zinc, beryllium, cobalt, iron, manganese, chromium, strontium, yttrium and zirconium are selectively adsorbed by the cationic resin; adjusting the pH of the second ion-containing solution to within a range of from about 5.0 to about 6.0; contacting the pH adjusting second ion-containing solution with a dextran-based material for a time to selectively separate niobium from the solution and recovering the niobium from the dextran-based material.

  19. Fixed Target Experiments at the Fermilab Tevatron

    SciTech Connect (OSTI)

    Gutierrez, Gaston; Reyes, Marco A.

    2014-11-10

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of ?s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include ?+?-, K0s K0s, K0s K±??, ?? and D. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D.

  20. Targeting Illegal Immigration: Local Ordinate Action 

    E-Print Network [OSTI]

    Gunn, Emily; Moffitt, Jessica; Montemayor, Victoria; Riedel, Sarah; Smith, Bart; Weizel, Daniel

    2008-01-01

    to prevent unauthorized immigration. However, from 1990 to 2005, estimates of the unauthorized alien population in the United States have risen from 3.5 million to 11.5 million people, a 325 percent increase. A small number of localities have taken action... to unauthorized aliens, while others passed legislation targeting day labor centers, loitering, and government services. Consistent with findings made in other studies,1 at the time of our study we found that only approximately 100 localities have...

  1. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  2. Independent Oversight Targeted Review, Sandia National Laboratories -

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof EnergyApril 2014 | Department of Energy Targeted Review, Sandia

  3. Water Use Reduction in Buildings Objective: Thoroughly analyze the water use in a targeted New York City building,

    E-Print Network [OSTI]

    Wolberg, George

    Water Use Reduction in Buildings Objective: Thoroughly analyze the water use in a targeted New York City building, identify causes of over-use, recommend modifications that will improve water use it will exceed the capacities of the City's drinking water and waste water infrastructure. Thus

  4. Designing high power targets with computational fluid dynamics (CFD)

    SciTech Connect (OSTI)

    Covrig, S. D.

    2013-11-07

    High power liquid hydrogen (LH2) targets, up to 850 W, have been widely used at Jefferson Lab for the 6 GeV physics program. The typical luminosity loss of a 20 cm long LH2 target was 20% for a beam current of 100 ?A rastered on a square of side 2 mm on the target. The 35 cm long, 2500 W LH2 target for the Qweak experiment had a luminosity loss of 0.8% at 180 ?A beam rastered on a square of side 4 mm at the target. The Qweak target was the highest power liquid hydrogen target in the world and with the lowest noise figure. The Qweak target was the first one designed with CFD at Jefferson Lab. A CFD facility is being established at Jefferson Lab to design, build and test a new generation of low noise high power targets.

  5. Identified Patent Waiver W(I)2012-003

    Broader source: Energy.gov [DOE]

    This is a request by UCHICAGO ARGONNE, LLC for a DOE Identified patent waiver of domestic and foreign patent rights under agreement DE-AC02-06CH11357.

  6. Identified Patent Waiver W(I)2012-005

    Broader source: Energy.gov [DOE]

    This is a request by UCHICAGO ARGONNE, LLC for a DOE Identified patent waiver of domestic and foreign patent rights under agreement DE-AC02-06CH11357.

  7. Identified Patent Waiver W(I)2012-004

    Broader source: Energy.gov [DOE]

    This is a request by UCHICAGO ARGONNE, LLC for a DOE Identified patent waiver of domestic and foreign patent rights under agreement DE-AC02-06CH11357.

  8. Identifying and removing sources of imprecision in polynomial regression

    E-Print Network [OSTI]

    Brauner, Neima

    Identifying and removing sources of imprecision in polynomial regression Neima Braunera and removal of imprecision in polynomial regression, originating from random errors (noise) in the independent.V. Keywords: Regression; Polynomial; Precision; Noise; Collinearity 1. Introduction Mathematical modeling

  9. Identifying Callous-Unemotional Subtypes among Justice-Involved Youth 

    E-Print Network [OSTI]

    Magyar, Melissa Sue

    2014-08-06

    Considerable evidence suggests that the presence of a callous and unemotional interpersonal style identifies an important subgroup of antisocial and aggressive youth. Relative to other children with conduct problems, youth high on callous...

  10. Automatically Identifying Candidate Treatments from Existing Medical Literature

    E-Print Network [OSTI]

    Pratt, Wanda

    fish oil to treat Raynaud's disease (Swanson and Smalheiser 1997). Medical scientists are nowAutomatically Identifying Candidate Treatments from Existing Medical Literature Catherine Blake to transform the titles to known medical concepts, and the other applied additional semantic constraints

  11. Identified Patent Waiver W(I)2012-012

    Broader source: Energy.gov [DOE]

    This is a request by DR. F. JEFFREY MARTIN for a DOE Identified patent waiver of domestic and foreign patent rights under agreement DE-AC52-06NA25396.

  12. Manual for Identifying and Protecting Official Use Only Information

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-09

    This Department of Energy (DOE) Manual provides detailed requirements to supplement DOE O 471.3, Identifying and Protecting Official Use Only Information, dated 4-9-03. Admin Chg dated 1-13-11.

  13. Ab initio thermodynamic approach to identify mixed solid sorbents...

    Office of Scientific and Technical Information (OSTI)

    Identifier: 1223713 Report Number(s): NETL-PUB-20049 Journal ID: ISSN 2296-665X Resource Type: Journal Article Resource Relation: Journal Name: Frontiers in Environmental Science;...

  14. Identifying and Developing New, Carbon Dioxide Consuming Processes , Sudheer Indalaa

    E-Print Network [OSTI]

    Pike, Ralph W.

    acceptable, catalytic processes have been identified that can use excess high purity carbon dioxide as a raw in the ethylbenzene-to-styrene reaction, and it can be used in dehydrogenation and reforming reactions. The criteria

  15. Identified Patent Waiver W(I)2012-002

    Office of Energy Efficiency and Renewable Energy (EERE)

    This is a request by BATTELLE MEMORIAL INSTITUTE for a DOE Identified patent waiver of domestic and foreign patent rights under agreement DE-AC07-05ID14517.

  16. Using patient­identifiable data for observational research and audit 

    E-Print Network [OSTI]

    Al-Shahi, Rustam; Warlow, Charles P

    2000-01-01

    Across the world rapid changes in the law, technology, and society are reshaping the way identifiable information about patients is handled. In Britain, doctors' longstanding common law duty of confidentiality to their ...

  17. LEAN ENERGY ANALYSIS: IDENTIFYING, DISCOVERING AND TRACKING ENERGY SAVINGS POTENTIAL

    E-Print Network [OSTI]

    Kissock, Kelly

    LEAN ENERGY ANALYSIS: IDENTIFYING, DISCOVERING AND TRACKING ENERGY SAVINGS POTENTIAL KELLY KISSOCK DEPARTMENT OF MECHANICAL AND AEROSPACE ENGINEERING UNIVERSITY OF DAYTON DAYTON, OHIO JOHN SERYAK ENERGY AND RESOURCE SOLUTIONS HAVERHILL, MASSECHUTSETTS ABSTRACT Energy in manufacturing facilities is used for direct

  18. Coupling Groundwater Modeling with Biology to Identify Strategic Water Resources

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Coupling Groundwater Modeling with Biology to Identify Strategic Water Resources Didier Graillot 1 ABSTRACT The identification of hydraulic interactions between rivers and groundwater is part and parcel hinders groundwater modeling everywhere and simulating water management scenarios in every place

  19. Decommissioning and PIE of the MEGAPIE spallation target

    SciTech Connect (OSTI)

    Latge, C.; Henry, J.; Wohlmuther, M.; Dai, Y.; Gavillet, D.; Hammer, B.; Heinitz, S.; Neuhausen, J.; Schumann, D.; Thomsen, K.; Tuerler, A.; Wagner, W.; Gessi, A.; Guertin, A.; Konstantinovic, M.; Lindau, R.; Maloy, S.; Saito, S.

    2013-07-01

    A key experiment in the Accelerated Driven Systems roadmap, the MEGAwatt PIlot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute. The target has been designed, manufactured, and tested during integral tests, before irradiation carried out end of 2006. During irradiation, neutron and thermo hydraulic measurements were performed allowing deep interpretation of the experiment and validation of the models used during design phase. The decommissioning, Post Irradiation Examinations and waste management phases were defined properly. The phases dedicated to cutting, sampling, cleaning, waste management, samples preparation and shipping to various laboratories were performed by PSI teams: all these phases constitute a huge work, which allows now to perform post-irradiation examination (PIE) of structural material, irradiated in relevant conditions. Preliminary results are presented in the paper, they concern chemical characterization. The following radio-nuclides have been identified by ?-spectrometry: {sup 60}Co, {sup 101}Rh, {sup 102}Rh, {sup 108m}Ag, {sup 110m}Ag, {sup 133}Ba, {sup 172}Hf/Lu, {sup 173}Lu, {sup 194}Hg/Au, {sup 195}Au, {sup 207}Bi. For some of these nuclides the activities can be easily evaluated from ?-spectrometry results ({sup 207}Bi, {sup 194}Hg/Au), while other nuclides can only be determined after chemical separations ({sup 108m}Ag, {sup 110m}Ag, {sup 195}Au, {sup 129}I, {sup 36}Cl and ?-emitting {sup 208-210}Po). The concentration of {sup 129}I is lower than expected. The chemical analysis already performed on spallation and corrosion products in the lead-bismuth eutectic (LBE) are very relevant for further applications of LBE as a spallation media and more generally as a coolant.

  20. A comparison of regulatory impacts to real target impacts

    SciTech Connect (OSTI)

    Ammerman, D.J.

    1998-05-01

    The purpose of this paper is to discuss the relative severity of regulatory impacts onto an essentially rigid target to impacts at higher velocities onto real targets. For impacts onto the essentially rigid target all of the kinetic energy of the package is absorbed by deformation of the package. For impacts onto real targets the kinetic energy is absorbed by deformation of the target as well as by deformation of the package. The amount of kinetic energy absorbed by the target does not increase the severity of the impact.

  1. Fuel Target Implosion in Ion beam Inertial Confinement Fusion

    E-Print Network [OSTI]

    Kawata, Shigeo

    2015-01-01

    The numerical results for the fuel target implosion are presented in order to clarify the target physics in ion beam inertial fusion. The numerical analyses are performed for a direct-driven ion beam target. In the paper the following issues are studied: the beam obliquely incidence on the target surface, the plasma effect on the beam-stopping power, the beam particle energy, the beam time duration, the target radius, the beam input energy and the non-uniformity effect on the fuel target performance. In this paper the beam ions are protons.

  2. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    SciTech Connect (OSTI)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  3. Target GmbH | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing CapacityVectren)ModelTalbotts Ltd JumpJumpInformationTaosTarget GmbH

  4. OMEGA Targets - Laboratory for Laser Energetics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you notHeatMaRIEdioxideUser WorkEP Power Conditioning -PowerTargets -

  5. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDid you not find whatGasEnergyfeature photoTheory05 Target 1 Flight

  6. A method for relating impacts with yielding and unyielding targets

    SciTech Connect (OSTI)

    Ammerman, D.J.

    1991-01-01

    The public has questioned the severity of the regulatory 9 meter drop onto an unyielding target required for Type B radioactive material shipping packages since this drop height results in an impact velocity of only 13.3 m/s (30 MPH). It is the unyielding nature of the regulatory target which makes the 9 meter drop so severe. In this paper a method for relating higher velocity impacts with yielding targets to impacts onto an unyielding target is developed. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. There have been previous attempts to correlate impacts with yielding targets to lower velocity impacts onto an unyielding target, and this work is an expansion of those efforts.

  7. A method for relating impacts with yielding and unyielding targets

    SciTech Connect (OSTI)

    Ammerman, D.J.

    1991-12-31

    The public has questioned the severity of the regulatory 9 meter drop onto an unyielding target required for Type B radioactive material shipping packages since this drop height results in an impact velocity of only 13.3 m/s (30 MPH). It is the unyielding nature of the regulatory target which makes the 9 meter drop so severe. In this paper a method for relating higher velocity impacts with yielding targets to impacts onto an unyielding target is developed. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. There have been previous attempts to correlate impacts with yielding targets to lower velocity impacts onto an unyielding target, and this work is an expansion of those efforts.

  8. Targeting the Poor: Evidence from a Field Experiment in Indonesia

    E-Print Network [OSTI]

    Alatas, Vivi

    This paper reports an experiment in 640 Indonesian villages on three approaches to target the poor: proxy means tests (PMT), where assets are used to predict consumption; community targeting, where villagers rank everyone ...

  9. Investigating Festival's target cost function using perceptual experiments 

    E-Print Network [OSTI]

    Strom, Volker; King, Simon

    2008-01-01

    We describe an investigation of the target cost used in the Festival unit selection speech synthesis system. Our ultimate goal is to automatically learn a perceptually optimal target cost function. In this study, we ...

  10. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  11. Laser Radar Point-Target Localization at High Photon Efficiency

    E-Print Network [OSTI]

    Shapiro, Jeffrey H.

    2013-01-01

    Minimum error-probability laser radar point-target localization is analyzed, including the effects of dark counts, background counts, and target speckle. Results from preliminary table-top experiments are reported.

  12. A Study of Scientometric Methods to Identify Emerging Technologies

    SciTech Connect (OSTI)

    Abercrombie, Robert K [ORNL] [ORNL; Udoeyop, Akaninyene W [ORNL] [ORNL

    2011-01-01

    This work examines a scientometric model that tracks the emergence of an identified technology from initial discovery (via original scientific and conference literature), through critical discoveries (via original scientific, conference literature and patents), transitioning through Technology Readiness Levels (TRLs) and ultimately on to commercial application. During the period of innovation and technology transfer, the impact of scholarly works, patents and on-line web news sources are identified. As trends develop, currency of citations, collaboration indicators, and on-line news patterns are identified. The combinations of four distinct and separate searchable on-line networked sources (i.e., scholarly publications and citation, worldwide patents, news archives, and on-line mapping networks) are assembled to become one collective network (a dataset for analysis of relations). This established network becomes the basis from which to quickly analyze the temporal flow of activity (searchable events) for the example subject domain we investigated.

  13. Target molecules detection by waveguiding in a photonic silicon membrane

    DOE Patents [OSTI]

    Letant, Sonia E. (Livermore, CA); Van Buuren, Anthony (Livermore, CA); Terminello, Louis (Danville, CA); Hart, Bradley R. (Brentwood, CA)

    2006-12-26

    Disclosed herein is a porous silicon filter capable of binding and detecting biological and chemical target molecules in liquid or gas samples. A photonic waveguiding silicon filter with chemical and/or biological anchors covalently attached to the pore walls bind target molecules. The system uses transmission curve engineering principles to allow measurements to be made in situ and in real time to detect the presence of various target molecules and calculate the concentration of bound target.

  14. Optimization Studies for ISOL Type High-Powered Targets

    SciTech Connect (OSTI)

    Remec, Igor; Ronningen, Reginald Martin

    2013-09-24

    The research studied one-step and two-step Isotope Separation on Line (ISOL) targets for future radioactive beam facilities with high driver-beam power through advanced computer simulations. As a target material uranium carbide in the form of foils was used because of increasing demand for actinide targets in rare-isotope beam facilities and because such material was under development in ISAC at TRIUMF when this project started. Simulations of effusion were performed for one-step and two step targets and the effects of target dimensions and foil matrix were studied. Diffusion simulations were limited by availability of diffusion parameters for UCx material at reduced density; however, the viability of the combined diffusion?effusion simulation methodology was demonstrated and could be used to extract physical parameters such as diffusion coefficients and effusion delay times from experimental isotope release curves. Dissipation of the heat from the isotope-producing targets is the limiting factor for high-power beam operation both for the direct and two-step targets. Detailed target models were used to simulate proton beam interactions with the targets to obtain the fission rates and power deposition distributions, which were then applied in the heat transfer calculations to study the performance of the targets. Results indicate that a direct target, with specification matching ISAC TRIUMF target, could operate in 500-MeV proton beam at beam powers up to ~40 kW, producing ~8 1013 fission/s with maximum temperature in UCx below 2200 C. Targets with larger radius allow higher beam powers and fission rates. For the target radius in the range 9-mm to 30-mm the achievable fission rate increases almost linearly with target radius, however, the effusion delay time also increases linearly with target radius.

  15. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A.

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  16. Die-target for dynamic powder consolidation

    DOE Patents [OSTI]

    Flinn, J.E.; Korth, G.E.

    1985-06-27

    A die/target is disclosed for consolidation of a powder, especially an atomized rapidly solidified metal powder, to produce monoliths by the dynamic action of a shock wave, especially a shock wave produced by the detonation of an explosive charge. The die/target comprises a rectangular metal block having a square primary surface with four rectangular mold cavities formed therein to receive the powder. The cavities are located away from the geometrical center of the primary surface and are distributed around such center while also being located away from the geometrical diagonals of the primary surface to reduce the action of reflected waves so as to avoid tensile cracking of the monoliths. The primary surface is covered by a powder retention plate which is engaged by a flyer plate to transmit the shock wave to the primary surface and the powder. Spawl plates are adhesively mounted on other surfaces of the block to act as momentum traps so as to reduce reflected waves in the block. 4 figs.

  17. Recovery of germanium-68 from irradiated targets

    DOE Patents [OSTI]

    Phillips, Dennis R. (Los Alamos, NM); Jamriska, Sr., David J. (Los Alamos, NM); Hamilton, Virginia T. (Los Alamos, NM)

    1993-01-01

    A process for selective separation of germanium-68 from proton irradiated molybdenum targets is provided and includes dissolving the molybdenum target in a hydrogen peroxide solution to form a first ion-containing solution, contacting the first ion-containing solution with a cationic resin whereby ions selected from the group consisting of molybdenum, niobium, technetium, selenium, vanadium, arsenic, germanium, zirconium and rubidium remain in a second ion-containing solution while ions selected from the group consisting of rubidium, zinc, beryllium, cobalt, iron, manganese, chromium, strontium, yttrium and zirconium are selectively adsorbed by the first resin, adjusting the pH of the second ion-containing solution to within a range of from about 0.7 to about 3.0, adjusting the soluble metal halide concentration in the second ion-containing solution to a level adapted for subsequent separation of germanium, contacting the pH-adjusted, soluble metal halide-containing second ion-containing solution with a dextran-based material whereby germanium ions are separated by the dextran-based material, and recovering the germanium from the dextran-based material, preferably by distillation.

  18. Electron Scattering with Polarized Targets at TESLA

    E-Print Network [OSTI]

    The TESLA-N Study Group; :; M. Anselmino; E. C. Aschenauer; S. Belostotski; W. Bialowons; J. Bluemlein; V. Braun; R. Brinkmann; M. Dueren; F. Ellinghaus; K. Goeke; St. Goertz; A. Gute; J. Harmsen; D. v. Harrach; R. Jakob; E. M. Kabuss; R. Kaiser; V. Korotkov; P. Kroll; E. Leader; B. Lehmann-Dronke; L. Mankiewicz; A. Meier; W. Meyer; N. Meyners; D. Mueller; P. J. Mulders; W. -D. Nowak; L. Niedermeier; K. Oganessyan; P. V. Pobilitsa; M. V. Polyakov; G. Reicherz; K. Rith; D. Ryckbosch; A. Schaefer; K. Sinram; G. v. d. Steenhoven; E. Steffens; J. Steijger; C. Weiss

    2000-11-24

    Measurements of polarized electron-nucleon scattering can be realized at the TESLA linear collider facility with projected luminosities that are about two orders of magnitude higher than those expected of other experiments at comparable energies. Longitudinally polarized electrons, accelerated as a small fraction of the total current in the e+ arm of TESLA, can be directed onto a solid state target that may be either longitudinally or transversely polarized. A large variety of polarized parton distribution and fragmentation functions can be determined with unprecedented accuracy, many of them for the first time. A main goal of the experiment is the precise measurement of the x- and Q^2-dependence of the experimentally totally unknown quark transversity distributions that will complete the information on the nucleon's quark spin structure as relevant for high energy processes. Comparing their Q^2-evolution to that of the corresponding helicity distributions constitutes an important precision test of the predictive power of QCD in the spin sector. Measuring transversity distributions and tensor charges allows access to the hitherto unmeasured chirally odd operators in QCD which are of great importance to understand the role of chiral symmetry. The possibilities of using unpolarized targets and of experiments with a real photon beam turn TESLA-N into a versatile next-generation facility at the intersection of particle and nuclear physics.

  19. UAV PATH FOLLOWING FOR TARGET OBSERVATION IN WIND

    E-Print Network [OSTI]

    UAV PATH FOLLOWING FOR TARGET OBSERVATION IN WIND Rolf Rysdyk, University of Washington, Seattle guidance and syn- chronous camera angles to observe a target from an unmanned-aerial-vehicle (UAV).1 Semi- autonomous operation of UAVs for target sensing have shown that operator situational awareness can be easily

  20. LA-UR-98-5674 Magnetized Target Fusion

    E-Print Network [OSTI]

    LA-UR-98-5674 Magnetized Target Fusion: A burning FRC plasma in an imploded metal can G. A. Wurden Reversed Configuration (FRC) target plasma for Magnetized Target Fusion (MTF) experiments, using theta using the MOQUI FRC code shows that the required plasma can be formed using conical theta pinch coils

  1. Methods for targetted mutagenesis in gram-positive bacteria

    SciTech Connect (OSTI)

    Yang, Yunfeng

    2014-05-27

    The present invention provides a method of targeted mutagenesis in Gram-positive bacteria. In particular, the present invention provides a method that effectively integrates a suicide integrative vector into a target gene in the chromosome of a Gram-positive bacterium, resulting in inactivation of the target gene.

  2. Method of making segmented pyrolytic graphite sputtering targets

    DOE Patents [OSTI]

    McKernan, M.A.; Alford, C.S.; Makowiecki, D.M.; Chen, C.W.

    1994-02-08

    Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface. 2 figures.

  3. Neutrinos from Stored Muons STORM Target Station Conceptualg p

    E-Print Network [OSTI]

    McDonald, Kirk

    beamline chase with adequate shielding · Active beamline elements include: - Production target Focusing Supply Lines OOuter Conductor Water Scavenge Tank #12;STORM Target Station Conceptual Design Approach techniques T h hi ldi l ld b l i· Target chase shielding steel would be mostly comprise of relatively

  4. Method of making segmented pyrolytic graphite sputtering targets

    DOE Patents [OSTI]

    McKernan, Mark A. (Livermore, CA); Alford, Craig S. (Tracy, CA); Makowiecki, Daniel M. (Livermore, CA); Chen, Chih-Wen (Livermore, CA)

    1994-01-01

    Anisotropic pyrolytic graphite wafers are oriented and bonded together such that the graphite's high thermal conductivity planes are maximized along the back surface of the segmented pyrolytic graphite target to allow for optimum heat conduction away from the sputter target's sputtering surface and to allow for maximum energy transmission from the target's sputtering surface.

  5. Neutron producing target for accelerator based neutron source for

    E-Print Network [OSTI]

    Taskaev, Sergey Yur'evich

    247 Neutron producing target for accelerator based neutron source for NCT V. Belov1 , S. Fadeev1, Russia Summary Neutron producing targets for novel accelerator based neutron source [1, 2] are presented Neutron producing target is one of the main elements of proposed accelerator based facility for neutron

  6. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  7. Identifying Biomarkers and Mechanisms of Toxic Metal Stress with Global Proteomics

    SciTech Connect (OSTI)

    Miller, Susan M.

    2012-04-16

    Hg is a wide-spread contaminant in the environment and is toxic in all of its various forms. Data suggest that RHg+ and Hg2+ are toxic in two ways. At low levels, Hg species appear to disrupt membrane-bound respiration causing a burst of reactive oxygen species (ROS) that further damage the cell. At higher Hg concentrations, RHg+ and Hg2+ may form adducts with cysteine- and selenocysteine-containing proteins in all cellular compartments resulting in their inactivation. Although these mechansims for toxicity are generally accepted, the most sensitive targets associated with these mechanisms are not well understood. In this collaborative project involving three laboratories at three institutions, the overall goal was to develop of a mass spectrometry-based global proteomics methodology that could be used to identify Hg-adducted (and ideally, ROS-damaged) proteins in order to address these types of questions. The two objectives of this overall collaborative project were (1) to identify, quantify, and compare ROS- and Hg-damaged proteins in cells treated with various Hg species and concentrations to test this model for two mechanisms of Hg toxicity, and (2) to define the cellular roles of the ubiquitous bacterial mercury resistance (mer) locus with regards to how the proteins of this pathway interact to protect other cell proteins from Hg damage. The specific objectives and accomplishments of the Miller lab in this project included: (1) Development of algorithms for analysis of the Hg-proteomic mass spectrometry data to identify mercury adducted peptides and other trends in the data. (2) Investigation of the role of mer operon proteins in scavenging Hg(II) from other mer pathway proteins as a means of protecting cellular proteins from damage.

  8. Identifying Pollutant Sources in Tidally Mixed Systems: Case Study

    E-Print Network [OSTI]

    Winant, Clinton D.

    sitessas a primary source of fecal indicator bacteria in the water column and subtidal sediments and magnitude of pollutant sources potentially responsible for the impairment. While this information mayIdentifying Pollutant Sources in Tidally Mixed Systems: Case Study of Fecal Indicator Bacteria from

  9. Identifying Sources of Nitrogen to Hanalei Bay, Kauai, Utilizing the

    E-Print Network [OSTI]

    Paytan, Adina

    Identifying Sources of Nitrogen to Hanalei Bay, Kauai, Utilizing the Nitrogen Isotope Signature, Menlo Park, California 94025, and P.O. Box 681, Kilauea, Hawaii 96754 Sewage effluent, storm runoff of land derived nutrients into Hanalei Bay, Kauai. We determined the nitrogen isotopic signatures (15N

  10. AN ANALYSIS PROCESS FOR IDENTIFYING AND FORMALIZING LMS INSTRUCTIONAL LANGUAGE

    E-Print Network [OSTI]

    Laforcade, Pierre

    AN ANALYSIS PROCESS FOR IDENTIFYING AND FORMALIZING LMS INSTRUCTIONAL LANGUAGE Aymen Abedmouleh. Abstract: Today, the LMS systems require some reengineering works or some additional design approaches designing their learning scenarios. In this paper, we propose an LMS centered instructional design approach

  11. Identifying Proxy Nodes in a Tor Anonymization Circuit Sambuddho Chakravarty

    E-Print Network [OSTI]

    Keromytis, Angelos D.

    Identifying Proxy Nodes in a Tor Anonymization Circuit Sambuddho Chakravarty Columbia University, and effective mechanism that exposes the identity of Tor relays participating in a given circuit. Such an attack), we create observable fluctuations that propagate through the Tor network and the Internet to the end

  12. Engineering Identifying the source of an atmospheric pollutant

    E-Print Network [OSTI]

    associated with increased mortality and lung disease) whose sources in models used to develop air pollutionChemical Engineering Abstract Identifying the source of an atmospheric pollutant or phenomena challenge currently facing the US EPA in developing secondary standards for the control of this pollutant

  13. Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene

    E-Print Network [OSTI]

    that activation of the ERK and phos- phatidylinositol 3-kinase (PI3K) signaling path- ways cooperate to transform T (LT) and small t (ST) oncoproteins, and an activated allele of H-RAS (H-RASV12 ) render a wide range exhibited by human epi- thelial cancers complicates efforts to identify mutations critical for malignant

  14. A Chemical Stain for Identifying Arsenic-Treated Wood

    E-Print Network [OSTI]

    Florida, University of

    A Chemical Stain for Identifying Arsenic-Treated Wood (FINAL) Submitted June 23, 2006 Amy Omae-TREATED WOOD II.1 Applying Phosphate Stains to Arsenate Stains 7 II.2 A Potential Arsenic-Test Kit 14 II.3 Whole Wood Application of the Modified Stannous Chloride Stain 19 II.4 Other Attempted Stain

  15. Classifying Web Search Queries to Identify High Revenue Generating Customers

    E-Print Network [OSTI]

    Jansen, James

    searching, the set of terms for which a user searches is called the query. If a user enters a query and then clicks on a result, these query terms are embedded within the URL that is passed from the search engineClassifying Web Search Queries to Identify High Revenue Generating Customers Adan Ortiz-Cordova 329

  16. A SIMPLE ALGORITHM FOR IDENTIFYING ABBREVIATION DEFINITIONS IN BIOMEDICAL TEXT

    E-Print Network [OSTI]

    Hearst, Marti

    A SIMPLE ALGORITHM FOR IDENTIFYING ABBREVIATION DEFINITIONS IN BIOMEDICAL TEXT ARIEL S. SCHWARTZ of biomedical text is growing at a fast rate, creating challenges for humans and computer systems alike. One of these challenges arises from the frequent use of novel abbreviations in these texts, thus requiring that biomedical

  17. Identifying Differences in Cultural Behavior in Online Groups

    SciTech Connect (OSTI)

    Gregory, Michelle L.; Engel, David W.; Bell, Eric B.; Mcgrath, Liam R.

    2012-07-23

    We have developed methods to identify online communities, or groups, using a combination of structural information variables and content information variables from weblog posts and their comments to build a characteristic footprint for groups. We have worked with both explicitly connected groups and 'abstract' groups, in which the connection between individuals is in interest (as determined by content based features) and behavior (metadata based features) as opposed to explicit links. We find that these variables do a good job at identifying groups, placing members within a group, and helping determine the appropriate granularity for group boundaries. The group footprint can then be used to identify differences between the online groups. In the work described here we are interested in determining how an individual's online behavior is influenced by their membership in more than one group. For example, individuals belong to a certain culture; they may belong as well to a demographic group, and other 'chosen' groups such as churches or clubs. There is a plethora of evidence surrounding the culturally sensitive adoption, use, and behavior on the Internet. In this work we begin to investigate how culturally defined internet behaviors may influence behaviors of subgroups. We do this through a series of experiments in which we analyze the interaction between culturally defined behaviors and the behaviors of the subgroups. Our goal is to (a) identify if our features can capture cultural distinctions in internet use, and (b) determine what kinds of interaction there are between levels and types of groups.

  18. Identifying Cross-Cutting Concerns Using Software Repository Mining

    E-Print Network [OSTI]

    Zaidman, Andy

    Identifying Cross-Cutting Concerns Using Software Repository Mining Frank Mulder Software and/or a fee. IWPSE-EVOL'10 September 20-21, 2010 Antwerp, Belgium Copyright 2010 ACM 978 Framework #12;3.2 Tool-chain Structure 3.3 Data Acquisition 3.4 Frequent Itemset Mining 3.4.1 Definition #12

  19. ORIGINAL ARTICLE Marine flooding event in continental Triassic facies identified

    E-Print Network [OSTI]

    Benton, Michael

    representing a high-energy event and records exceptional marine flooding in a distal fluvial environmentORIGINAL ARTICLE Marine flooding event in continental Triassic facies identified by a nothosaur Springer-Verlag Berlin Heidelberg 2013 Abstract Sudden marine flooding within otherwise con- tinental

  20. Sequencing and comparison of yeast species to identify genes

    E-Print Network [OSTI]

    Kellis, Manolis

    *, Nick Patterson*, Matthew Endrizzi*, Bruce Birren* & Eric S. Lander* * Whitehead/MIT Center for Genome ........................................................................................................................................................................................................................... Identifying the functional elements encoded in a genome is one of the principal challenges in modern biology. Comparative genomics should offer a powerful, general approach. Here, we present a comparative analysis

  1. All-codon scanning identifies p53 cancer rescue mutations

    E-Print Network [OSTI]

    Lathrop, Richard H.

    . We have used ACS to produce single amino-acid changes in small and large regions of the human tumor suppressor protein p53 to identify single amino-acid substitutions that can restore activity to inactive p53 in a single codon, typically do not achieve saturation, may introduce multiple amino acid changes per product

  2. Encounter dynamics of a small target by a polymer diffusing in a confined domain

    E-Print Network [OSTI]

    A. Amitai; Carlo Amoruso; Avi Ziskind; D. Holcman

    2013-01-17

    We study the first passage time for a polymer, that we call the narrow encounter time (NETP), to reach a small target located on the surface of a microdomain. The polymer is modeled as a Freely Joint Chain (beads connected by springs with a resting non zero length) and we use Brownian simulations to study two cases: when (i) any of the monomer or (ii) only one can be absorbed at the target window. Interestingly, we find that {in the first case} the NETP is an increasing function of the polymer length until a critical length, after which it decreases. Moreover, in the long polymer regime, we identified an exponential scaling law for the NETP as a function of the polymer length. {In the second case, the position of the absorbed monomer along the polymer chain strongly influences the NETP}. Our analysis can be applied to estimate the mean first time of a DNA fragment to a small target in the chromatin structure or for mRNA to find a small target.

  3. Target Discrimination in Synthetic Aperture Radar (SAR) using Artificial Neural Networks 1 TargetDiscriminationinSyntheticApertureRadar(SAR)

    E-Print Network [OSTI]

    Slatton, Clint

    Target Discrimination in Synthetic Aperture Radar (SAR) using Artificial Neural Networks 1 Target principe@cnel.ufl.edu Abstract: This paper addresses target discrimination in synthetic aperture radar (SAR classification but here the goal is discrimination. We will show that the two applications require different cost

  4. DEVELOPMENT AND ON-LINE TESTS OF DIFFERENT TARGET-ION SOURCE UNITS FOR PRODUCTION OF NUCLIDES FAR FROM STABILITY

    E-Print Network [OSTI]

    Titov, Anatoly

    288 DEVELOPMENT AND ON-LINE TESTS OF DIFFERENT TARGET-ION SOURCE UNITS FOR PRODUCTION OF NUCLIDES of an effective, high-temperature target unit for the on-line production of short-lived rare nuclides and Lu, and of many other nuclides with boiling points higher than 3000°C. The use of tungsten container

  5. Measurement of Particle Production from the MICE Target

    SciTech Connect (OSTI)

    Soler, F. J. P.; Walaron, K.; Booth, C.; Carson, M.; Hodgson, P.; Howlett, L.; Smith, P.; Adams, D.; Edgecock, R.; Murray, W.; Tilley, K.; Cobb, J.; Rayner, M.; Roberts, T.

    2008-02-21

    This article describes the prototype target and the requirements for the target mechanism needed to provide a beam of muons to the Muon Ionization Cooling Experiment (MICE) from the ISIS accelerator at RAL. The mechanism has achieved the required 85g acceleration to be able to insert the target into the ISIS beam during the last 2 ms of the accelerating period. A prototype target test was used to integrate the target into ISIS and to measure the ISIS beam envelope, particle yields and beam loss, showing good agreement between data and simulations.

  6. Technologies for Mass Producing IFE Targets and Determining Their Survival in an IFE Target Chamber

    E-Print Network [OSTI]

    ) Microencapsulation: oil­water­oil double emulsion (ii) Wall-thickness control (iii)Solvent removal--CO2 critical;OMEGA-scale DT-wetted foam targets have demonstrated acceptable capsule and ice specifications E19652. Thickness uniformity of the foam wall DT ice layer in the foam capsule ­1-nm-rms roughness Foam capsule:

  7. Cryogenic target formation using cold gas jets

    DOE Patents [OSTI]

    Hendricks, Charles D. [Livermore, CA

    1980-02-26

    A method and apparatus using cold gas jets for producing a substantially uniform layer of cryogenic materials on the inner surface of hollow spherical members having one or more layers, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on an inner surface of the spherical member. Basically the method involves directing cold gas jets onto a spherical member having one or more layers or shells and containing the cryogenic material, such as a deuterium-tritium (DT) mixture, to freeze the contained material, momentarily heating the spherical member so as to vaporize the contained material, and quickly refreezing the thus vaporized material forming a uniform layer of cryogenic material on an inner surface of the spherical member.

  8. Cryogenic target formation using cold gas jets

    DOE Patents [OSTI]

    Hendricks, C.D.

    1980-02-26

    A method and apparatus using cold gas jets for producing a substantially uniform layer of cryogenic materials on the inner surface of hollow spherical members having one or more layers, such as inertially imploded targets are disclosed. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on an inner surface of the spherical member. Basically the method involves directing cold gas jets onto a spherical member having one or more layers or shells and containing the cryogenic material, such as a deuterium-tritium (DT) mixture, to freeze the contained material, momentarily heating the spherical member so as to vaporize the contained material, and quickly refreezing the thus vaporized material forming a uniform layer of cryogenic material on an inner surface of the spherical member. 4 figs.

  9. Tenth target fabrication specialists` meeting: Proceedings

    SciTech Connect (OSTI)

    Foreman, L.R.; Stark, J.C.

    1995-11-01

    This tenth meeting of specialists in target fabrication for inertial confinement is unique in that it is the first meeting that was completely unclassified. As a result of the new classification, we were able to invite more foreign participation. In addition to participants from the US, UK, and Canada, representatives from France, Japan, and two Russian laboratories attended, about 115 in all. This booklet presents full papers and poster sessions. Indirect and direct drive laser implosions are considered. Typical topics include: polymer or aluminium or resorcinol/formaldehyde shells, laser technology, photon tunneling microscopy as a characterization tool, foams, coatings, hohlraums, and beryllium capsules. Hydrogen, deuterium, tritium, and beryllium are all considered as fuels.

  10. Cryogenic target formation using cold gas jets

    DOE Patents [OSTI]

    Hendricks, Charles D. (Livermore, CA)

    1981-01-01

    A method and apparatus using cold gas jets for producing a substantially uniform layer of cryogenic materials on the inner surface of hollow spherical members having one or more layers, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on an inner surface of the spherical member. Basically the method involves directing cold gas jets onto a spherical member having one or more layers or shells and containing the cryogenic material, such as a deuterium-tritium (DT) mixture, to freeze the contained material, momentarily heating the spherical member so as to vaporize the contained material, and quickly refreezing the thus vaporized material forming a uniform layer of cryogenic material on an inner surface of the spherical member.

  11. Laser-fusion targets for reactors

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA)

    1987-01-01

    A laser target comprising a thermonuclear fuel capsule composed of a centrally located quantity of fuel surrounded by at least one or more layers or shells of material for forming an atmosphere around the capsule by a low energy laser prepulse. The fuel may be formed as a solid core or hollow shell, and, under certain applications, a pusher-layer or shell is located intermediate the fuel and the atmosphere forming material. The fuel is ignited by symmetrical implosion via energy produced by a laser, or other energy sources such as an electron beam machine or ion beam machine, whereby thermonuclear burn of the fuel capsule creates energy for applications such as generation of electricity via a laser fusion reactor.

  12. CALIFORNIA ENERGY COMMISSION Administered ARRA Funded Programs (2/17/10) State Energy Program $226 million

    E-Print Network [OSTI]

    and water efficiency, renewable energy, smart grid and clean transportation fields. ARRA Funding: $20. ARRA Funding: $25 million Target Audience: City and county governments Leveraged Funding million Target Audience: Community colleges, training & employment partnerships, cities & counties

  13. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  14. The aligned nuclear targets for investigation of time reversal invariance violation: thermal heating and optimization of target dimension

    E-Print Network [OSTI]

    A. G. Beda; A. S. Gerasimov

    2007-06-18

    The thermal heating of aligned nuclear targets of HIO_3, LiIO_3 ans Sb target materials under neutron irradiation at JSNS is considered. It is shown that presently the targets of large volumes (several tens of cm^3) can be used in experiment. The optimal target dimensions are recommended for investigation with resonance neutrons. The use of proposed aligned targets at the new neutron spallation source JSNS (Japan) will make p[ossible to discover TRIV or decrease the present limit on the intensity of parity conserving time violating interaction by two-three order of magnitude.

  15. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target

    E-Print Network [OSTI]

    Watanabe, Hideo

    The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To study the transcriptional impact of NKX2-1 amplification, we generated an ...

  16. Numerical Simulation and Laboratory Testing of Time-Frequency MUSIC Beamforming for Identifying Continuous and Impulsive Ground Targets from a Mobile Aerial Platform 

    E-Print Network [OSTI]

    Silva, Ramon Alejandro

    2013-04-25

    , this method can be adapted for a real-time processing. Consider xm(t) to represent sound pressure data measured by the m th microphone of an array and sampled at frequency fs, where t denotes time. From Fig. 2.2, a cluster of 12 N data points, x m(tn....2. Extraction of N data points centered at time step tn. Fig. 2.3 shows a Hanning window, w1 with length D, applied to x m(tn), starting from ?1 = tn ? (N/2)?(1/fs), where D must be smaller than N. A Hanning window is applied in attempts to mitigate...

  17. A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL

    E-Print Network [OSTI]

    Torella, Rubben; Li, Jinghua; Kinrade, Eddie; Cerda-Moya, Gustavo; Contreras, Ashley N.; Foy, Robert; Stojnic, Robert; Glen, Robert C.; Kovall, Rhett A.; Adryan, Boris; Bray, Sarah J.

    2014-08-11

    protocol MD simulations were performed with the AMBER11 package (http://ambermd.org/) (27), using the AMBER FF99SB force field (28). All calculations were made with the CUDA enabled version of PMEMD (29), using TESLA GPUs at the High Performance Computing...

  18. Fragmentation cross sections of Fe^{26+}, Si^{14+} and C^{6+} ions of 0.3-10 A GeV on polyethylene, CR39 and aluminum targets

    E-Print Network [OSTI]

    S. Cecchini; T. Chiarusi; G. Giacomelli; M. Giorgini; A. Kumar; G. Mandrioli; S. Manzoor; A. R. Margiotta; E. Medinaceli; L. Patrizii; V. Popa; I. E. Qureshi; G. Sirri; M. Spurio; V. Togo

    2008-01-21

    We present new measurements of the total and partial fragmentation cross sections in the energy range 0.3-10 A GeV of 56Fe, 28Si and 12C beams on polyethylene, CR39 and aluminum targets. The exposures were made at BNL, USA and HIMAC, Japan. The CR39 nuclear track detectors were used to identify the incident and survived beams and their fragments. The total fragmentation cross sections for all targets are almost energy independent while they depend on the target mass. The measured partial fragmentation cross sections are also discussed.

  19. Fragmentation cross sections of Fe^{26+}, Si^{14+} and C^{6+} ions of 0.3-10 A GeV on CR39, polyethylene and aluminum targets

    E-Print Network [OSTI]

    Miriam Giorgini

    2008-12-01

    New measurements of the total and partial fragmentation cross sections in the energy range 0.3-10 A GeV of Fe^{26+}, Si^{14+} and C^{6+} beams on polyethylene, CR39 and aluminum targets are presented. The exposures were made at Brookhaven National Laboratory (BNL), USA, and Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. The CR39 nuclear track detectors were used to identify the incident and survived beams and their fragments. The total fragmentation cross sections for all targets are almost energy independent while they depend on the target mass. The measured partial fragmentation cross sections are also discussed.

  20. Methods for identifying an essential gene in a prokaryotic microorganism

    DOE Patents [OSTI]

    Shizuya, Hiroaki

    2006-01-31

    Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombination. This system offers an enhanced means of identifying essential function genes in diploid pathogens, such as gram-negative and gram-positive bacteria.

  1. Identifying, Implementing and Complying with Environment, Safety and Health Requirements

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-05-15

    This Policy sets forth the framework for identifying, implementing and complying with environment, safety and health (ES&H) requirements so that work is performed in the DOE complex in a manner that ensures adequate protection of workers, the public and the environment. Ownership of this policy is shared between GC and HS. Cancels DOE P 450.2. Canceled by DOE P 450.4A.

  2. Methods for characterizing, classifying, and identifying unknowns in samples

    DOE Patents [OSTI]

    Grate, Jay W.; Wise, Barry M.

    2003-08-12

    Disclosed is a method for taking the data generated from an array of responses from a multichannel instrument, and determining the characteristics of a chemical in the sample without the necessity of calibrating or training the instrument with known samples containing the same chemical. The characteristics determined by the method are then used to classify and identify the chemical in the sample. The method can also be used to quantify the concentration of the chemical in the sample.

  3. Methods for characterizing, classifying, and identifying unknowns in samples

    DOE Patents [OSTI]

    Grate, Jay W [West Richland, WA; Wise, Barry M [Manson, WA

    2002-01-01

    Disclosed is a method for taking the data generated from an array of responses from a multichannel instrument, and determining the characteristics of a chemical in the sample without the necessity of calibrating or training the instrument with known samples containing the same chemical. The characteristics determined by the method are then used to classify and identify the chemical in the sample. The method can also be used to quantify the concentration of the chemical in the sample.

  4. Method for processing seismic data to identify anomalous absorption zones

    DOE Patents [OSTI]

    Taner, M. Turhan

    2006-01-03

    A method is disclosed for identifying zones anomalously absorptive of seismic energy. The method includes jointly time-frequency decomposing seismic traces, low frequency bandpass filtering the decomposed traces to determine a general trend of mean frequency and bandwidth of the seismic traces, and high frequency bandpass filtering the decomposed traces to determine local variations in the mean frequency and bandwidth of the seismic traces. Anomalous zones are determined where there is difference between the general trend and the local variations.

  5. Identify Institutional Change Tools for Sustainability | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingREnergy Tools for Sustainability Identify Institutional

  6. Identify and Protect Your Vital Records | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy ServicesContractingManagement »HydrogenINTERACTIVE:Identify and

  7. Identifying, studying and making good use of macromolecular crystals

    SciTech Connect (OSTI)

    Calero, Guillermo; Cohen, Aina E.; Luft, Joseph R.; Newman, Janet; Snell, Edward H.

    2014-07-25

    As technology advances, the crystal volume that can be used to collect useful X-ray diffraction data decreases. The technologies available to detect and study growing crystals beyond the optical resolution limit and methods to successfully place the crystal into the X-ray beam are discussed. Structural biology has contributed tremendous knowledge to the understanding of life on the molecular scale. The Protein Data Bank, a depository of this structural knowledge, currently contains over 100 000 protein structures, with the majority stemming from X-ray crystallography. As the name might suggest, crystallography requires crystals. As detectors become more sensitive and X-ray sources more intense, the notion of a crystal is gradually changing from one large enough to embellish expensive jewellery to objects that have external dimensions of the order of the wavelength of visible light. Identifying these crystals is a prerequisite to their study. This paper discusses developments in identifying these crystals during crystallization screening and distinguishing them from other potential outcomes. The practical aspects of ensuring that once a crystal is identified it can then be positioned in the X-ray beam for data collection are also addressed.

  8. Construction of an unyielding target for large horizontal impacts.

    SciTech Connect (OSTI)

    Ammerman, Douglas James; Davie, Neil Thomas; Kalan, Robert J.

    2010-10-01

    Sandia National Laboratories has constructed an unyielding target at the end of its 2000-foot rocket sled track. This target is made up of approximately 5 million pounds of concrete, an embedded steel load spreading structure, and a steel armor plate face that varies from 10 inches thick at the center to 4 inches thick at the left and right edges. The target/track combination will allow horizontal impacts at regulatory speeds of very large objects, such as a full-scale rail cask, or high-speed impacts of smaller packages. The load-spreading mechanism in the target is based upon the proven design that has been in use for over 20 years at Sandia's aerial cable facility. That target, with a weight of 2 million pounds, has successfully withstood impact forces of up to 25 million pounds. It is expected that the new target will be capable of withstanding impact forces of more than 70 million pounds. During construction various instrumentation was placed in the target so that the response of the target during severe impacts can be monitored. This paper will discuss the construction of the target and provide insights on the testing capabilities at the sled track with this new target.

  9. Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4

    E-Print Network [OSTI]

    Ren, Yin

    The comprehensive characterization of a large number of cancer genomes will eventually lead to a compendium of genetic alterations in specific cancers. Unfortunately, the number and complexity of identified alterations ...

  10. Performance limits for exo-clutter Ground Moving Target Indicator (GMTI) radar.

    SciTech Connect (OSTI)

    Doerry, Armin Walter

    2010-09-01

    The performance of a Ground Moving Target Indicator (GMTI) radar system depends on a variety of factors, many which are interdependent in some manner. It is often difficult to 'get your arms around' the problem of ascertaining achievable performance limits, and yet those limits exist and are dictated by physics. This report identifies and explores those limits, and how they depend on hardware system parameters and environmental conditions. Ultimately, this leads to a characterization of parameters that offer optimum performance for the overall GMTI radar system. While the information herein is not new to the literature, its collection into a single report hopes to offer some value in reducing the 'seek time'.

  11. Method of detecting luminescent target ions with modified magnetic microspheres

    DOE Patents [OSTI]

    Shkrob, Ilya A; Kaminski, Michael D

    2014-05-13

    This invention provides methods of using modified magnetic microspheres to extract target ions from a sample in order to detect their presence in a microfluidic environment. In one or more embodiments, the microspheres are modified with molecules on the surface that allow the target ions in the sample to form complexes with specific ligand molecules on the microsphere surface. In one or more embodiments, the microspheres are modified with molecules that sequester the target ions from the sample, but specific ligand molecules in solution subsequently re-extract the target ions from the microspheres into the solution, where the complexes form independent of the microsphere surface. Once the complexes form, they are exposed to an excitation wavelength light source suitable for exciting the target ion to emit a luminescent signal pattern. Detection of the luminescent signal pattern allows for determination of the presence of the target ions in the sample.

  12. Support Facility for a Mercury Target Neutrino Factory

    SciTech Connect (OSTI)

    Spampinato, P.T.

    2001-12-06

    A conceptual design for a neutrino-producing facility is presented, including the mercury-jet target system, beam absorber, and facility for the target/capture region. The mercury system is a closed loop that includes a containment structure in the high-magnetic field region, a mercury pool beam absorber, conventional equipment such as magnetic-coupled pumps, valves, a heat exchanger, and a special nozzle insert. The superconducting solenoids in the target region are protected from nuclear heating and radiation damage with water-cooled tungsten-carbide shielding; the decay channel solenoids are protected with water-cooled steel shielding. The target region and decay channel have high-neutron fluxes resulting in components that are highly activated. Therefore, the facility configuration is based on remotely maintaining the target system and the magnets, as well as providing sufficient shielding for personnel. Summaries of cost estimates for the target system, magnet shielding, maintenance equipment, and the facility are also presented.

  13. Preliminary safety assessment for an IFE target fabrication facility

    SciTech Connect (OSTI)

    Latkowski, J F; Reyes, S; Besenbruch, G E; Goodin, D T

    2000-10-13

    We estimate possible ranges of tritium inventories for an inertial fusion energy (IFE) target fabrication facility producing various types of targets and using various production technologies. Target fill is the key subtask in determining the overall tritium inventory for the plant. By segmenting the inventory into multiple, parallel production lines--each with its own fill canister--and including an expansion tank to limit releases, we are able to ensure that a target fabrication facility would meet the accident dose goals of 10 mSv (1 rem) set forth in the Department of Energy's Fusion Safety Standards. For indirect-drive targets, we calculate release fractions for elements from lithium to bismuth and show that nearly all elements meet the dose goal. Our work suggests directions for future R&D that will help reduce total tritium inventories and increase the flexibility of target fabrication facilities.

  14. B-Target Room Tunnel Redesigned

    SciTech Connect (OSTI)

    Esfandiari, Reza; /San Jose State U. /SLAC

    2010-08-25

    Several groups at SLAC National Accelerator Laboratory are currently working on a RF Modulator prototype for a future linear collider known as the International Linear Collider (ILC). The ILC runs using about a 1000 Klystrons which create high power carrier waves for the particle acceleration. Klystrons receive their electrical input power from modulators. In order to move beyond the prototype phase, the laboratory might expand its ground base further down a tunnel located at the End Station B (ESB) in order to house four new Klystron Modulator Test Stations. This area is known as the B-Target Room Tunnel, and the task was to redesign the tunnel layout for the upcoming changes. The project first began by collecting substantial amount of information about the prototyped project, the tunnel and the researchers feedback of what they would like to see in the upcoming design. Subsequent to numerous planning and presentations, one particular design was. Calculations for this design were then performed for the most complex aspects of the project. Based on the results of the calculations, specific sample beams, welds, bolts and materials were chosen for the possible future construction.

  15. Automatic target recognition apparatus and method

    DOE Patents [OSTI]

    Baumgart, Chris W. (Santa Fe, NM); Ciarcia, Christopher A. (Los Alamos, NM)

    2000-01-01

    An automatic target recognition apparatus (10) is provided, having a video camera/digitizer (12) for producing a digitized image signal (20) representing an image containing therein objects which objects are to be recognized if they meet predefined criteria. The digitized image signal (20) is processed within a video analysis subroutine (22) residing in a computer (14) in a plurality of parallel analysis chains such that the objects are presumed to be lighter in shading than the background in the image in three of the chains and further such that the objects are presumed to be darker than the background in the other three chains. In two of the chains the objects are defined by surface texture analysis using texture filter operations. In another two of the chains the objects are defined by background subtraction operations. In yet another two of the chains the objects are defined by edge enhancement processes. In each of the analysis chains a calculation operation independently determines an error factor relating to the probability that the objects are of the type which should be recognized, and a probability calculation operation combines the results of the analysis chains.

  16. Superstring Compactification and Target Space Duality

    E-Print Network [OSTI]

    John H. Schwarz

    1991-08-26

    This review talk focusses on some of the interesting developments in the area of superstring compactification that have occurred in the last couple of years. These include the discovery that ``mirror symmetric" pairs of Calabi--Yau spaces, with completely distinct geometries and topologies, correspond to a single (2,2) conformal field theory. Also, the concept of target-space duality, originally discovered for toroidal compactification, is being extended to Calabi--Yau spaces. It also associates sets of geometrically distinct manifolds to a single conformal field theory. A couple of other topics are presented very briefly. One concerns conceptual challenges in reconciling gravity and quantum mechanics. It is suggested that certain ``distasteful allegations" associated with quantum gravity such as loss of quantum coherence, unpredictability of fundamental parameters of particle physics, and paradoxical features of black holes are likely to be circumvented by string theory. Finally there is a brief discussion of the importance of supersymmetry at the TeV scale, both from a practical point of view and as a potentially significant prediction of string theory.

  17. Repetitive output laser system and method using target reflectivity

    DOE Patents [OSTI]

    Johnson, Roy R. (Ann Arbor, MI)

    1978-01-01

    An improved laser system and method for implosion of a thermonuclear fuel pellet in which that portion of a laser pulse reflected by the target pellet is utilized in the laser system to initiate a succeeding target implosion, and in which the energy stored in the laser system to amplify the initial laser pulse, but not completely absorbed thereby, is used to amplify succeeding laser pulses initiated by target reflection.

  18. Polarized nuclear target based on parahydrogen induced polarization

    SciTech Connect (OSTI)

    D. Budker, M.P. Ledbetter, S. Appelt, L.S. Bouchard, B. Wojtsekhowski

    2012-12-01

    We discuss a novel concept of a polarized nuclear target for accelerator fixed-target scattering experiments, which is based on parahydrogen induced polarization (PHIP). One may be able to reach a 33% free-proton polarization in the ethane molecule. The potential advantages of such a target include operation at zero magnetic field, fast ({approx}100 HZ) polarization oscillation (akin to polarization reversal), and operation with large intensity of an electron beam.

  19. The target laboratory of the Pelletron Accelerator's facilities

    SciTech Connect (OSTI)

    Ueta, Nobuko; Pereira Engel, Wanda Gabriel [Nuclear Physics Department - University of Sao Paulo (Brazil)

    2013-05-06

    A short report on the activities developed in the Target Laboratory, since 1970, will be presented. Basic target laboratory facilities were provided to produce the necessary nuclear targets as well as the ion beam stripper foils. Vacuum evaporation units, a roller, a press and an analytical balance were installed in the Oscar Sala building. A brief historical report will be presented in commemoration of the 40{sup th} year of the Pelletron Accelerator.

  20. Potential hazards to embryo implantation: A human endometrial in vitro model to identify unwanted antigestagenic actions of chemicals

    SciTech Connect (OSTI)

    Fischer, L.; Deppert, W.R. [Department of Obstetrics and Gynecology, University Hospital Freiburg (Germany)] [Department of Obstetrics and Gynecology, University Hospital Freiburg (Germany); Pfeifer, D. [Department of Hematology and Oncology, University Hospital Freiburg (Germany)] [Department of Hematology and Oncology, University Hospital Freiburg (Germany); Stanzel, S.; Weimer, M. [Department of Biostatistics, German Cancer Research Center, Heidelberg (Germany)] [Department of Biostatistics, German Cancer Research Center, Heidelberg (Germany); Hanjalic-Beck, A.; Stein, A.; Straßer, M.; Zahradnik, H.P. [Department of Obstetrics and Gynecology, University Hospital Freiburg (Germany)] [Department of Obstetrics and Gynecology, University Hospital Freiburg (Germany); Schaefer, W.R., E-mail: wolfgang.schaefer@uniklinik-freiburg.de [Department of Obstetrics and Gynecology, University Hospital Freiburg (Germany)

    2012-05-01

    Embryo implantation is a crucial step in human reproduction and depends on the timely development of a receptive endometrium. The human endometrium is unique among adult tissues due to its dynamic alterations during each menstrual cycle. It hosts the implantation process which is governed by progesterone, whereas 17?-estradiol regulates the preceding proliferation of the endometrium. The receptors for both steroids are targets for drugs and endocrine disrupting chemicals. Chemicals with unwanted antigestagenic actions are potentially hazardous to embryo implantation since many pharmaceutical antiprogestins adversely affect endometrial receptivity. This risk can be addressed by human tissue-specific in vitro assays. As working basis we compiled data on chemicals interacting with the PR. In our experimental work, we developed a flexible in vitro model based on human endometrial Ishikawa cells. Effects of antiprogestin compounds on pre-selected target genes were characterized by sigmoidal concentration–response curves obtained by RT-qPCR. The estrogen sulfotransferase (SULT1E1) was identified as the most responsive target gene by microarray analysis. The agonistic effect of progesterone on SULT1E1 mRNA was concentration-dependently antagonized by RU486 (mifepristone) and ZK137316 and, with lower potency, by 4-nonylphenol, bisphenol A and apigenin. The negative control methyl acetoacetate showed no effect. The effects of progesterone and RU486 were confirmed on the protein level by Western blotting. We demonstrated proof of principle that our Ishikawa model is suitable to study quantitatively effects of antiprogestin-like chemicals on endometrial target genes in comparison to pharmaceutical reference compounds. This test is useful for hazard identification and may contribute to reduce animal studies. -- Highlights: ? We compare progesterone receptor-mediated endometrial effects of chemicals and drugs. ? 4-Nonylphenol, bisphenol A and apigenin exert weak antigestagenic activity. ? SULT1E1 is a significant marker for endometrial antiprogestin effects. ? Ishikawa cells are a tissue-specific approach for characterization of SPRMs. ? Chemicals acting as progesterone receptor antagonists may exert antifertility effects.

  1. Apparatus for controlling system state based on unique identifiers

    DOE Patents [OSTI]

    Drotning, William D. (Albuquerque, NM)

    2002-01-01

    An apparatus allows workers to assert and release control over the energization of a system. The apparatus does not require the workers to carry any additional paraphernalia, and is not be easily defeated by other workers. Users asserting and releasing control present tokens uniquely identifying each user to a reader, and the apparatus prevents transition of the system to an undesired state until an appropriate number of users are currently asserting control. For example, a dangerous manufacturing robot can be prevented from energizing until all the users that have asserted control when entering the robot's controlled space have subsequently released control when leaving the robot's controlled space.

  2. Portable data collection device with self identifying probe

    DOE Patents [OSTI]

    French, Patrick D. (Aurora, CO)

    1998-01-01

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of time. The sensor may also store a unique sensor identifier.

  3. Portable data collection device with self identifying probe

    DOE Patents [OSTI]

    French, P.D.

    1998-11-17

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of time. The sensor may also store a unique sensor identifier. 13 figs.

  4. Research identifies designs for lowering subsea production cost

    SciTech Connect (OSTI)

    Rothberg, R.H.; Hall, J.E. ); Douglas, L.D. ); Manuel, W.S. ); Kirkland, K.G.

    1993-03-08

    To reduce costs and simplify installation operations for subsea hardware, Amoco Production Co. in 1986 began the development of a diverless subsea production system (DSPS). At present, Amoco has completed the testing phase for selected prototype components and has completed a deepwater system design that incorporates many of these ideas. This program has yielded several configurations suitable for full-field development; however, the emphasis of the research and development program has been to identify, design, and test components of key subsystems. This first of a three-part series describes the design considerations, equipment configuration, and subsea trees.

  5. Identifying Critical Pathways to High-Performance PV: Preprint

    SciTech Connect (OSTI)

    Symko-Davies, M.; Noufi, R.; Kurtz, S.

    2002-05-01

    This conference paper describes the High-Performance Photovoltaic (HiPerf PV)Project was initiated by the U.S. Department of Energy to substantially increase the viability of photovoltaics (PV) for cost-competitive applications so that PV can contribute significantly to our energy supply and our environment in the 21st century. To accomplish this, the NCPV directs in-house and subcontracted research in high-performance polycrystalline thin-film and multijunction concentrator devices. Details of the subcontractor and in-house progress will be described toward identifying critical pathways of 25% polycrystalline thin-film tandem cells and developing multijunction concentrator modules to 33%.

  6. Two-Factor Identify Proofing Process | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative FuelsofProgram: Report1538-1950 Timeline ofTurkey Near-Zero Zone TurkeyofofIdentify

  7. Microsoft Word - 2013 IWD #3155 Trident Target Area Operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for radiation exposure monitoring. Attenuate particle beams appropriately to minimize the activation of target chamber and associated components. Radiation Protection P-121...

  8. Enterprise Assessments Targeted Review, Management of the Safety...

    Energy Savers [EERE]

    Volt Diesel Bus Battery-Backed Power System of the Idaho National Laboratory Advanced Test Reactor -October 2015 Enterprise Assessments Targeted Review, Management of the...

  9. Laser Integration Line target diagnostics first results (invited...

    Office of Scientific and Technical Information (OSTI)

    and high resolution spectrometers have been fabricated in the frame of a unique industrial contract. Optical pointers are used to align the diagnostics to the target. The...

  10. Mutations and genetic targets for enhanced L-tyrosine production

    SciTech Connect (OSTI)

    Santos, Christine; Stephanopoulos, Gregory

    2014-05-27

    The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production.

  11. Office of Enterprise Assessments Lessons Learned From Targeted...

    Broader source: Energy.gov (indexed) [DOE]

    Lessons Learned From Targeted Reviews of Radiological Controls Activity-Level Implementation May 2011 September 2014 January 2015 Office of Nuclear Safety and Environmental...

  12. Geobotanical Remote Sensing Applied To Targeting New Geothermal...

    Open Energy Info (EERE)

    "http:en.openei.orgwindex.php?titleGeobotanicalRemoteSensingAppliedToTargetingNewGeothermalResourceLocationsInTheUsBasinAndRangeWithAFocusOnDixieMeadows,...

  13. Effectiveness of Shallow Temperatures Surveys to Target a Geothermal...

    Open Energy Info (EERE)

    Effectiveness of Shallow Temperatures Surveys to Target a Geothermal Reservoir at Previously Explored Site at Mcgee Mountain, Nevada Jump to: navigation, search OpenEI Reference...

  14. Application of Target Value Design to Energy Efficiency Investments

    E-Print Network [OSTI]

    Lee, Hyun Woo

    2012-01-01

    the Conceptualization, Criteria Design, and Detailed Designand Expected Benefits Criteria Design to Targets Set-baseddesign based on the design criteria, and proceeds to design

  15. Calif. Utilities play catchup with Ever-Rising RPS targets

    SciTech Connect (OSTI)

    2008-08-15

    The current status of attempts by California's three major utilities to meet mandated targets for producing power from renewable energy sources are sketched.

  16. Protein engineering for targeted delivery of radionuclides to tumors

    E-Print Network [OSTI]

    Orcutt, Kelly Davis

    2010-01-01

    Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ...

  17. Overcomplete Radon Bases for Target Property Management in Sensor Networks

    E-Print Network [OSTI]

    Guibas, Leonidas J.

    Overcomplete Radon Bases for Target Property Management in Sensor Networks Xiaoye Jiang Stanford, exploiting an overcomplete Radon basis dictionary to model property uncertainty in such cir- cumstances

  18. Enterprise Assessments Targeted Review of the Fire Protection...

    Energy Savers [EERE]

    Targeted Review of the Fire Protection Program at the Oak Ridge National Laboratory Irradiated Fuels Examination Laboratory, Building 3525 - September 2015 Enterprise Assessments...

  19. Operational Experience of Target Systems for Neutrino Facilities

    E-Print Network [OSTI]

    McDonald, Kirk

    helium) Pros · Simple ­ no containment · Access to target/horn possible ·Simple ­ no containment · Clean, shielding, fluids, etc... ­ Intervention on equipment `impossible' · Remote handling by overhead crane

  20. Biotin compounds for targeting tumors and sites of infection

    DOE Patents [OSTI]

    Elmaleh, D.R.; Fischman, A.J.; Shoup, T.M.; Babich, J.W.

    1998-02-10

    Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.

  1. Development of aerogel-lined targets for inertial confinement...

    Office of Scientific and Technical Information (OSTI)

    ThesisDissertation: Development of aerogel-lined targets for inertial confinement fusion experiments Citation Details In-Document Search Title: Development of aerogel-lined...

  2. Development of aerogel-lined targets for inertial confinement...

    Office of Scientific and Technical Information (OSTI)

    aerogel-lined targets for inertial confinement fusion experiments Braun, T 36 MATERIALS SCIENCE Abstract not provided Lawrence Livermore National Laboratory (LLNL), Livermore, CA...

  3. Enterprise Assessments Targeted Review of the Paducah Depleted...

    Broader source: Energy.gov (indexed) [DOE]

    Targeted Review of the Fire Protection Program at the Paducah Depleted Uranium Hexafluoride Conversion Facility The U.S. Department of Energy (DOE) Office of Enterprise Assessments...

  4. Cyclotrons to Make Neutrons & Radioactive Targets for SBSS at...

    Office of Science (SC) Website

    Cyclotrons to Make Neutrons & Radioactive Targets for SBSS at LBNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear...

  5. Sigma-models having supermanifolds as target spaces

    E-Print Network [OSTI]

    Albert Schwarz

    1995-06-10

    We study a topological sigma-model ($A$-model) in the case when the target space is an ($m_0|m_1$)-dimensional supermanifold. We prove under certain conditions that such a model is equivalent to an $A$-model having an ($m_0-m_1$)-dimensional manifold as a target space. We use this result to prove that in the case when the target space of $A$-model is a complete intersection in a toric manifold, this $A$-model is equivalent to an $A$-model having a toric supermanifold as a target space.

  6. Recent Advances in Indirect Drive ICF Target Physics

    SciTech Connect (OSTI)

    Hammel, B; Lindl, J; Amendt, P A; Bernat, G W; Collins, G W; Glenzer, S H; Koch, S H; Haan, S; Landen, O L; Suter, L J

    2002-10-08

    In preparation for ignition on the National Ignition Facility, the Lawrence Livermore National Laboratory's Inertial Confinement Fusion Program, working in collaboration with Los Alamos National Laboratory, Commissariat a lEnergie Atomique (CEA), and Laboratory for Laser Energetics at the University of Rochester, has performed a broad range of experiments on the Nova and Omega lasers to test the fundamentals of the NIF target designs. These studies have refined our understanding of the important target physics, and have led to many of the specifications for the NIF laser and the cryogenic ignition targets. Our recent work has been focused in the areas of hohlraum energetics, symmetry, shock physics, and target design optimization & fabrication.

  7. Signal transduction in the chronic leukemias: implications for targeted therapies.

    E-Print Network [OSTI]

    Ahmed, Wesam; Van Etten, Richard A

    2013-01-01

    G, Fenouille N, et al. Resveratrol promotes autophagic cellmodulation of AMPK by resveratrol, a naturally occurring34]. Another target of resveratrol in CML is SIRT1, a novel

  8. Identifying Requirements for Effective Human-Automation Teamwork

    SciTech Connect (OSTI)

    Jeffrey C. Joe; John O'Hara; Heather D. Medema; Johanna H. Oxstrand

    2014-06-01

    Previous studies have shown that poorly designed human-automation collaboration, such as poorly designed communication protocols, often leads to problems for the human operators, such as: lack of vigilance, complacency, and loss of skills. These problems often lead to suboptimal system performance. To address this situation, a considerable amount of research has been conducted to improve human-automation collaboration and to make automation function better as a “team player.” Much of this research is based on an understanding of what it means to be a good team player from the perspective of a human team. However, the research is often based on a simplified view of human teams and teamwork. In this study, we sought to better understand the capabilities and limitations of automation from the standpoint of human teams. We first examined human teams to identify the principles for effective teamwork. We next reviewed the research on integrating automation agents and human agents into mixed agent teams to identify the limitations of automation agents to conform to teamwork principles. This research resulted in insights that can lead to more effective human-automation collaboration by enabling a more realistic set of requirements to be developed based on the strengths and limitations of all agents.

  9. Multivariate Techniques for Identifying Diffractive Interactions at the LHC

    E-Print Network [OSTI]

    Mikael Kuusela; Jerry W. Lamsa; Eric Malmi; Petteri Mehtala; Risto Orava

    2009-09-16

    Close to one half of the LHC events are expected to be due to elastic or inelastic diffractive scattering. Still, predictions based on extrapolations of experimental data at lower energies differ by large factors in estimating the relative rate of diffractive event categories at the LHC energies. By identifying diffractive events, detailed studies on proton structure can be carried out. The combined forward physics objects: rapidity gaps, forward multiplicity and transverse energy flows can be used to efficiently classify proton-proton collisions. Data samples recorded by the forward detectors, with a simple extension, will allow first estimates of the single diffractive (SD), double diffractive (DD), central diffractive (CD), and non-diffractive (ND) cross sections. The approach, which uses the measurement of inelastic activity in forward and central detector systems, is complementary to the detection and measurement of leading beam-like protons. In this investigation, three different multivariate analysis approaches are assessed in classifying forward physics processes at the LHC. It is shown that with gene expression programming, neural networks and support vector machines, diffraction can be efficiently identified within a large sample of simulated proton-proton scattering events. The event characteristics are visualized by using the self-organizing map algorithm.

  10. On the origin of super-hot electrons from intense laser interactions with solid targets having moderate scale length preformed plasmas

    SciTech Connect (OSTI)

    Krygier, A. G.; Schumacher, D. W.; Freeman, R. R.

    2014-02-15

    We use particle-in-cell modeling to identify the acceleration mechanism responsible for the observed generation of super-hot electrons in ultra-intense laser-plasma interactions with solid targets with pre-formed plasma. We identify several features of direct laser acceleration that drive the generation of super-hot electrons. We find that, in this regime, electrons that become super-hot are primarily injected by a looping mechanism that we call loop-injected direct acceleration.

  11. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  12. Effect of inactive impurities on the burning of ICF targets

    SciTech Connect (OSTI)

    Gus'kov, S. Yu. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Il'in, D. V.; Sherman, V. E. [St. Petersburg State Engineering Institute (Russian Federation)

    2011-12-15

    The efficiency of thermonuclear burning of the spherical deuterium-tritium (DT) plasma of inertial confinement fusion (ICF) targets in the presence of low-Z impurities (such as lithium, carbon, or beryllium) with arbitrary concentrations is investigated. The effect of impurities produced due to the mixing of the thermonuclear fuel with the material of the structural elements of the target during its compression on the process of target burning is studied, and the possibility of using solid noncryogenic thermonuclear fuels in ICF targets is analyzed. Analytical dependences of the ignition energy and target thermonuclear gain on the impurity concentration are obtained. The models are constructed for homogeneous and inhomogeneous plasmas for the case in which the burning is initiated in the central heated region of the target and then propagates into the surrounding relatively cold fuel. Two possible configurations of an inhomogeneous plasma, namely, an isobaric configuration formed in the case of spark ignition of the target and an isochoric configuration formed in the case of fast ignition, are considered. The results of numerical simulations of the burning of the DT plasma of ICF targets in a wide range of impurity concentrations are presented. The simulations were performed using the TEPA one-dimensional code, in which the thermonuclear burning kinetics is calculated by the Monte Carlo method. It is shown that the strongest negative effect related to the presence of impurities is an increase in the energy of target ignition. It is substantiated that the most promising solid noncryogenic fuel is DT hydride of beryllium (BeDT). The requirements to the plasma parameters at which BeDT can be used as a fuel in noncryogenic ICF targets are determined. Variants of using noncryogenic targets with a solid thermonuclear fuel are proposed.

  13. 70 DA WHITE DWARFS IDENTIFIED IN LAMOST PILOT SURVEY

    SciTech Connect (OSTI)

    Zhao, J. K.; Luo, A. L.; Zhao, G. [Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Oswalt, T. D., E-mail: zjk@bao.ac.cn, E-mail: gzhao@bao.ac.cn, E-mail: lal@bao.ac.cn, E-mail: toswalt@fit.edu [Physics and Space Science Department, Florida Institute of Technology, Melbourne, FL 32901 (United States)

    2013-06-01

    We present a spectroscopically identified catalog of 70 DA white dwarfs (WDs) from the LAMOST pilot survey. Thirty-five are found to be new identifications after cross-correlation with the Eisenstein et al. and Villanova catalogs. The effective temperature and gravity of these WDs are estimated by Balmer lines fitting. Most of them are hot WDs. The cooling times and masses of these WDs are estimated by interpolation in theoretical evolution tracks. The peak of the mass distribution is found to be {approx}0.6 M {sub Sun }, which is consistent with prior work in the literature. The distances of these WDs are estimated using the method of synthetic spectral distances. All of these WDs are found to be in the Galactic disk from our analysis of space motions. Our sample supports the expectation that WDs with high mass are concentrated near the plane of the Galactic disk.

  14. Interstellar HI Shells Identified in the SETHI Survey

    E-Print Network [OSTI]

    Sallmen, Shauna M; Bellehumeur, Brooke; Tennyson, Elizabeth M; Grunwald, Kurt; Lo, Cheuk Man

    2015-01-01

    Galactic HI (neutral hydrogen) shells are central to our understanding of the interstellar medium (ISM), which plays a key role in the development and evolution of galaxies, including our own. Several models involving supernovae and stellar winds have contributed to our broad understanding, but a complete, detailed picture remains elusive. To extend existing Galactic shell catalogs, we visually examined the SETHI (Search for Extraterrestrial HI) database to identify shell-like structures. This high-sensitivity 21-cm radio survey covering the Arecibo sky uniquely provides high-resolution data on shells at a wide range of Galactic latitudes. We present basic information (location, radial velocity, angular size, shape) for 74 previously unidentified HI shells. Due to limitations of coverage and data quality, and the biases inherent in search techniques, our catalog is not a complete sample of Galactic shells. We discuss the catalog completeness, and comment on the new shells' relationship with known interstellar...

  15. Identifying Calcium Channels and Porters in Plant Membranes

    SciTech Connect (OSTI)

    Sze, Heven

    1998-04-01

    The overall objectives of the proposal submitted in 6/90 was to understand how Ca was transported across plant membranes, and how these transport pathways were regulated. Ca participates in many cellular processes, including the transduction of hormonal and environmental signals, secretion, and protein folding. These processes depend on the coordination of passive Ca fluxes via channels and active Ca pumps; however these transport pathways are poorly understood in plants. We had, therefore, proposed to identify and characterize Ca transport proteins, such as the inositol-1 ,4,5-trisphosphate (IP3)-sensitive Ca channels and Ca pumps. We have had difficulties characterizing and cloning the IP3-sensitive Ca channel, but have made considerable progress on the biochemical characterization, and partial purification of a 120 kD Ca-pumping ATPase. We have begun to determine the structure of Ca pumps by molecular cloning and have already obtained a partial cDNA with features characteristic of Ca pumps.

  16. Summary of Mercury Compatibility Issues for the Spallation Neutron Source Target Containment and Ancillary Equipment

    SciTech Connect (OSTI)

    Pawel, SJ

    2003-04-08

    The purpose of this document is to summarize the primary results of the Hg compatibility research in support of the SNS target. In the absence of possible synergisms resulting from beam/irradiation effects, wetting of 316L/316LN stainless steel under SNS conditions by the Hg target is expected to be very limited. As a result, significant interactions such as dissolution, mass transfer, and embrittlement affecting general compatibility are not anticipated. A wide range of experiments on 316L/316LN stainless steel, including thermal convection and pumped loops, confirmed low corrosion/penetration rates in Hg up to 305 C and little or no wetting or mass transfer below about 250 C. A variety of standard mechanical tests comparing behavior of 316L in air and Hg revealed limited wetting and no degradation of mechanical properties such as reduced elongation or development of brittle fracture features. Preliminary fatigue tests indicated a negative effect (reduced cycles to failure and intergranular cracking) at very high loads for 316LN, but little or no effect at more modest loading. Annealed 316LN was found to be somewhat susceptible to cavitation-erosion damage, but significant improvement was realized with a kolsterizing surface treatment or coldworking the material. Within the scope of these test conditions, no compatibility-limited operations were identified for type 316L/316LN stainless steel (and variations thereof) as the Hg target containment material. More limited compatibility data on other materials are also reported.

  17. Adaptive Mobile Sensor Positioning for Multi-Static Target Tracking

    E-Print Network [OSTI]

    Swindlehurst, A. Lee

    improvements in battery, micro-controller, and sensor technologies have resulted in the development1 Adaptive Mobile Sensor Positioning for Multi-Static Target Tracking Pengcheng Zhan, David W UAV agents in a target tracking application where performance is improved by exploiting each agent

  18. UAV Coordination for Autonomous Target Tracking Richard A. Wise

    E-Print Network [OSTI]

    UAV Coordination for Autonomous Target Tracking Richard A. Wise and Rolf T. Rysdyk Autonomous different methodologies for tracking a moving target with multiple Unmanned Aerial Vehicles (UAVs). Relative position coordination of UAVs is en- forced. The comparison considers minimization of heuristics

  19. International Nuclear Target Development Society workshop 1983: proceedings

    SciTech Connect (OSTI)

    Thomas, G.

    1983-01-01

    Separate abstracts were prepared for 11 of the 19 papers presented. Eight papers were previously included in the data base. Discussion group session papers on carbon stripper foils, problems in producing heavy-ion targets, and problems in producing general type targets are included. (WHK)

  20. MERCURY HANDLING FOR THE TARGET SYSTEM FOR A MUON COLLIDER

    E-Print Network [OSTI]

    McDonald, Kirk

    angle to the magnetic axis, so as later to be collected in a mercury pool/beam dump. The replaceable target module includes the interaction region and mercury pool inside a primary containment vessel flow loop: The interaction region inside the target module: Cross section of the mercury pool: Services

  1. Analytical Target Cascading in Aircraft Design James Allison(1)

    E-Print Network [OSTI]

    Papalambros, Panos

    preliminary design. Top level system targets are cascaded through all elements in the hierarchy element design specifications have been obtained, the individual design tasks may be completedAnalytical Target Cascading in Aircraft Design James Allison(1) , David Walsh(2) , Michael

  2. Consumer Targeting in Residential Demand Response James C. Holyhead

    E-Print Network [OSTI]

    Molinari, Marc

    Consumer Targeting in Residential Demand Response Programmes James C. Holyhead Agents, Interaction and Computer Science University of Southampton, UK acr@ecs.soton.ac.uk ABSTRACT Demand response refers. In this paper we propose a novel approach to residential demand response, in which incentives are targeted

  3. Magneto-Inertial Fusion (Magnetized Target Fusion)( g g )

    E-Print Network [OSTI]

    LA-UR-11-01898 #12;Magneto-inertial fusion: A hybrid approach to fusion....ICF with a twistMagneto-Inertial Fusion (Magnetized Target Fusion)( g g ) or "why should we bother with another ICF boost performance (LLE, Omega) ·Magnetized Target Fusion (MTF) demonstration, FRCHX at AFRL

  4. High flux heat transfer in a target environment

    E-Print Network [OSTI]

    McDonald, Kirk

    Valid for: Consider turbulent heat transfer in a 1.5mm diameter pipe ­ Dittus Boelter correlationHigh flux heat transfer in a target environment T. Davenne High Power Targets Group Rutherford · Radiation Cooling · Forced Convection · Nucleate Boiling · Critical Heat Flux · Other ideas · Summary #12

  5. Lead-Bismuth Spallation Target Design Yousry Gohar

    E-Print Network [OSTI]

    McDonald, Kirk

    Driven System (100 MWt , 5 MW Beam, 600MeV Protons) #12;Target and Core Configuration of Accelerator Driven System #12;Lead-Bismuth Spallation Target Design A study was carried out to analyze and design Laboratory 9700 S. Cass Avenue, Argonne, IL 60439, USA Applications of High Intensity Proton Accelerators

  6. Models for Offender Target Location Selection with Explicit Dependency Structures

    E-Print Network [OSTI]

    O'Leary, Michael

    Models for Offender Target Location Selection with Explicit Dependency Structures Mike O'Leary April 30 - May 1, 2012 O'Leary & Tucker (Towson University) Target Location Selection QMDNS 2012 1 / 54 in this study We thank Phil Canter from the Baltimore County Police Department for his assistance. O'Leary

  7. Target selection and current status of structural genomics for the

    E-Print Network [OSTI]

    Babu, M. Madan

    33 Target selection and current status of structural genomics for the completed microbial genomes 3.2 Structural status of completed microbial genomes in the PDB................ 3.3 Metabolic pathways as targets for structural genomics.......................... 3.3.1 Glycolytic pathway

  8. Communication-Aware Navigation Functions for Cooperative Target Tracking

    E-Print Network [OSTI]

    Mostofi, Yasamin

    Communication-Aware Navigation Functions for Cooperative Target Tracking Alireza Ghaffarkhah of cooperative target tracking. We propose communication-aware navigation functions that allow the nodes in this area, however, assumes ideal or over- simplified communication links. For instance, it is common

  9. Accelerator Driven System Target Requirements and R&D

    E-Print Network [OSTI]

    McDonald, Kirk

    Accelerator Driven System Target Requirements and R&D Stuart Henderson Fermilab January 13, 2012 #12;Accelerator Driven Systems High-power, highly reliable proton accelerator · ~1 GeV beam energy and target technology for Accelerator-Driven Systems (ADS) · The White Paper was intended to make a hard

  10. Target Feasibility Achievement in Enterprise-Driven Hierarchical Multidisciplinary Design

    E-Print Network [OSTI]

    Chen, Wei

    problem where decisions on product design and market strategies are made simultaneously. In practicalTarget Feasibility Achievement in Enterprise-Driven Hierarchical Multidisciplinary Design Harrison is used to set the right targets for the engineering design process that maximize utility

  11. High power target design and operation considerations for kaon production

    E-Print Network [OSTI]

    McDonald, Kirk

    High power target design and operation considerations for kaon production Philip Pile Collider · LESBIII kaon production target/issues 24/19/2013 #12;PROTON BEAM FY96 FY97 FY98/99 FY2000 FY2001 FY2002 1012 per second during spill · Production Angle: 0 degrees · Particle Flux (per 1013, 22 Ge

  12. Optimizing Tree Reconfiguration for Mobile Target Tracking in Sensor Networks

    E-Print Network [OSTI]

    Zhang, Wensheng

    to facilitate sensor nodes collaborating in detecting and tracking a mobile target. As the target moves, many Advances in micro-electro-mechanics and wireless commu- nication have enabled the deployment of large scale locally waiting for queries from other nodes [4], or can be forwarded to multiple data centers (the sinks

  13. Distributed Mobility Management for Target Tracking in Mobile Sensor Networks

    E-Print Network [OSTI]

    Chakrabarty, Krishnendu

    --Wireless mobile sensor networks, mobility management, target tracking, Bayesian, distributed system. Ç 1 of scarce resources, such as energy and network bandwidth. Furthermore, the mobility management schemeDistributed Mobility Management for Target Tracking in Mobile Sensor Networks Yi Zou, Member, IEEE

  14. Design, maintenance and operational aspects of the CNGS target

    E-Print Network [OSTI]

    McDonald, Kirk

    Design, maintenance and operational aspects of the CNGS target M. Calviani (CERN-EN/STI) on behalfth May 2011MC - Design, maintenance and operational aspects of the CNGS target - 4th HPTW 2 #12;General layout of the CNGS installation 2nd-6th May 2011MC - Design, maintenance and operational aspects

  15. Mechanism of genotoxicity induced by targeted cytoplasmic irradiation

    E-Print Network [OSTI]

    Mechanism of genotoxicity induced by targeted cytoplasmic irradiation M Hong1,2 , A Xu1,3 , H Zhou1 irradiation should not be ignored in radiation risk estimation. Although targeted cytoplasmic irradiation has precision was used to study mechanisms involved in mediating the genotoxic effects in irradiated human

  16. Computational and experimental investigation of magnetized target fusion

    SciTech Connect (OSTI)

    Sheehey, P.T.; Guzik, J.A.; Kirkpatrick, R.C.; Lindemuth, I.R.; Scudder, D.W.; Shlachter, J.S.; Wysocki, F.J. [Los Alamos National Lab., NM (United States)

    1996-12-31

    In Magnetized Target Fusion (MTF), a preheated and magnetized target plasma is hydrodynamically compressed to fusion conditions. Because the magnetic field suppresses losses by electron thermal conduction in the fuel during the target implosion heating process, the compression may be over a much longer time scale than in traditional inertial confinement fusion (ICF). Bigger targets and much lower initial target densities than in ICF can be used, reducing radiative energy losses. Therefore, `liner-on-plasma` compressions, driven by relatively inexpensive electrical pulsed power, may be practical. Potential MTF target plasmas must meet minimum temperature, density, and magnetic field starting conditions, and must remain relatively free of high-Z radiation-cooling-enhancing contaminants. At Los Alamos National Laboratory, computational and experimental research is being pursued into MTF target plasmas, such as deuterium-fiber-initiated Z-pinches, and the Russian-originated `MAGO` plasma. In addition, liner-on-plasma compressions of such target plasmas to fusion conditions are being computationally modeled, and experimental investigation of such heavy liner implosions has begun. The status of the research will be presented. 9 refs., 4 figs.

  17. 6. Specular Planar Target Surface Recovery via Coded

    E-Print Network [OSTI]

    Jenkin, Michael R. M.

    6. Specular Planar Target Surface Recovery via Coded Target Stereopsis Arlene Ripsman, Piotr is designed to be highly specular in order to avoid unwanted heat- ing due to the absorption of sunlight specular nature of the surface poses a challenge to existing vision-based surface recovery algorithms

  18. Performance Analysis: Work Control Events Identified January - August 2010

    SciTech Connect (OSTI)

    De Grange, C E; Freeman, J W; Kerr, C E; Holman, G; Marsh, K; Beach, R

    2011-01-14

    This performance analysis evaluated 24 events that occurred at LLNL from January through August 2010. The analysis identified areas of potential work control process and/or implementation weaknesses and several common underlying causes. Human performance improvement and safety culture factors were part of the causal analysis of each event and were analyzed. The collective significance of all events in 2010, as measured by the occurrence reporting significance category and by the proportion of events that have been reported to the DOE ORPS under the ''management concerns'' reporting criteria, does not appear to have increased in 2010. The frequency of reporting in each of the significance categories has not changed in 2010 compared to the previous four years. There is no change indicating a trend in the significance category and there has been no increase in the proportion of occurrences reported in the higher significance category. Also, the frequency of events, 42 events reported through August 2010, is not greater than in previous years and is below the average of 63 occurrences per year at LLNL since 2006. Over the previous four years, an average of 43% of the LLNL's reported occurrences have been reported as either ''management concerns'' or ''near misses.'' In 2010, 29% of the occurrences have been reported as ''management concerns'' or ''near misses.'' This rate indicates that LLNL is now reporting fewer ''management concern'' and ''near miss'' occurrences compared to the previous four years. From 2008 to the present, LLNL senior management has undertaken a series of initiatives to strengthen the work planning and control system with the primary objective to improve worker safety. In 2008, the LLNL Deputy Director established the Work Control Integrated Project Team to develop the core requirements and graded elements of an institutional work planning and control system. By the end of that year this system was documented and implementation had begun. In 2009, training of the workforce began and as of the time of this report more than 50% of authorized Integration Work Sheets (IWS) use the activity-based planning process. In 2010, LSO independently reviewed the work planning and control process and confirmed to the Laboratory that the Integrated Safety Management (ISM) System was implemented. LLNL conducted a cross-directorate management self-assessment of work planning and control and is developing actions to respond to the issues identified. Ongoing efforts to strengthen the work planning and control process and to improve the quality of LLNL work packages are in progress: completion of remaining actions in response to the 2009 DOE Office of Health, Safety, and Security (HSS) evaluation of LLNL's ISM System; scheduling more than 14 work planning and control self-assessments in FY11; continuing to align subcontractor work control with the Institutional work planning and control system; and continuing to maintain the electronic IWS application. The 24 events included in this analysis were caused by errors in the first four of the five ISMS functions. The most frequent cause was errors in analyzing the hazards (Function 2). The second most frequent cause was errors occurring when defining the work (Function 1), followed by errors during the performance of work (Function 4). Interestingly, very few errors in developing controls (Function 3) resulted in events. This leads one to conclude that if improvements are made to defining the scope of work and analyzing the potential hazards, LLNL may reduce the frequency or severity of events. Analysis of the 24 events resulted in the identification of ten common causes. Some events had multiple causes, resulting in the mention of 39 causes being identified for the 24 events. The most frequent cause was workers, supervisors, or experts believing they understood the work and the hazards but their understanding was incomplete. The second most frequent cause was unclear, incomplete or confusing documents directing the work. Together, these two causes were mentioned 17 times and co

  19. Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super-Target Clustering1

    E-Print Network [OSTI]

    Chin, Francis Y.L.

    Predicting Drug-Target Interaction for New Drugs Using Enhanced Similarity Measures and Super.hku.hk, FYLC: chin@cs.hku.hk * To whom correspondence should be addressed. Abstract--Predicting drug-target interaction using computa- tional approaches is an important step in drug discovery and repositioning

  20. Identifying failure in a tree network of a parallel computer

    DOE Patents [OSTI]

    Archer, Charles J. (Rochester, MN); Pinnow, Kurt W. (Rochester, MN); Wallenfelt, Brian P. (Eden Prairie, MN)

    2010-08-24

    Methods, parallel computers, and products are provided for identifying failure in a tree network of a parallel computer. The parallel computer includes one or more processing sets including an I/O node and a plurality of compute nodes. For each processing set embodiments include selecting a set of test compute nodes, the test compute nodes being a subset of the compute nodes of the processing set; measuring the performance of the I/O node of the processing set; measuring the performance of the selected set of test compute nodes; calculating a current test value in dependence upon the measured performance of the I/O node of the processing set, the measured performance of the set of test compute nodes, and a predetermined value for I/O node performance; and comparing the current test value with a predetermined tree performance threshold. If the current test value is below the predetermined tree performance threshold, embodiments include selecting another set of test compute nodes. If the current test value is not below the predetermined tree performance threshold, embodiments include selecting from the test compute nodes one or more potential problem nodes and testing individually potential problem nodes and links to potential problem nodes.