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Sample records for ide emis sion

  1. Britt Ide | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Britt Ide About Us Britt Ide - President, Ide Law & Strategy, PLLC, C3E Ambassador Most Recent The Top Ten Things I Learned at the Ambassador Retreat September

  2. 2008 EMI SIG Meeting TWG

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mmsmw Welcome to the EMI-SIG Training Working Group ELECT V PERFECT Bob Burger and Charlie Brown 5 May 2008 EMI-SIG Training Working Group Objective Emergency Operations Center ...

  3. Energy Management Inc EMI | Open Energy Information

    Open Energy Info (EERE)

    Inc EMI Jump to: navigation, search Name: Energy Management Inc (EMI) Place: Boston, Massachusetts Zip: 21160 Sector: Wind energy Product: Independent project developer and parent...

  4. CB-EMIS WEB SERVICE SOFTWARE

    Energy Science and Technology Software Center (OSTI)

    2007-01-01

    This software provides CB-EMIS data to remote devices using a secure internet connection. The CB-EMIS Web Service filters and repackages data in a form suitable for resource limited devices such as a cell phone. Data transmission is filtered based on a user's authentical level. The web services acts as intermediary so that no direct connection is possible between the internet and the CB-EMIS server software.

  5. FRm : John A. Deny, DitiSion Of

    Office of Legacy Management (LM)

    to : lieads of Divisions am3 Man DAW.: December 6, 1954 FRm : John A. Deny, DitiSion Of SPNBOL : csm-R:AcB The attached tabulation of active AEC contracts over $l,ooO,Mx) haa been ,xepared as a result of recurring requests fcr infmmatirm cm ow larger contracts. It consists ox- Pa-t I - E+ime contracts and Pert II - Sub- ccdxacts, and lists the contracts alphabetically bq Operations Office to shar; (1) tne of work being prformed by the contractcr; (2) contract rmter; (3).ac&ated dollar

  6. Power converter having improved EMI shielding

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Kehl, Dennis L.; Gettelfinger, Lee A.; Kaishian, Steven C.; Phillips, Mark G.; Radosevich, Lawrence D.

    2006-06-13

    EMI shielding is provided for power electronics circuits and the like via a direct-mount reference plane support and shielding structure. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support forms a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  7. Vehicle drive module having improved EMI shielding

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Kehl, Dennis L.; Gettelfinger, Lee A.; Kaishian, Steven C.; Phillips, Mark G.; Radosevich, Lawrence D.

    2006-11-28

    EMI shielding in an electric vehicle drive is provided for power electronics circuits and the like via a direct-mount reference plane support and shielding structure. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support forms a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  8. CB-EMIS MAINTENANCE MONITORING SYSTEM

    Energy Science and Technology Software Center (OSTI)

    2006-10-01

    This system continuously monitors all components of a CB-EMIS (ANL-02-078)installation such as signals for video cameras, detector, train data, meteorological data, computer and network equipment and reports exceptions to maintenance staff so that corrections can be made as soon as possible. This monitoring system is built within Nagios (www.nagios.org), a free open source host service and network monitoring program.

  9. CB-EMIS CELL PHONE CLIENT

    Energy Science and Technology Software Center (OSTI)

    2007-01-02

    The cell phone software allows any Java enabled cell phone to view sensor and meteorological data via an internet connection using a secure connection to the CB-EMIS Web Service. Users with appropriate privileges can monitor the state of the sensors and perform simple maintenance tasks remotely. All sensitive data is downloaded from the web service, thus protecting sensitive data in the event a cell phone is lost.

  10. RAPID/Roadmap/8-ID-e | Open Energy Information

    Open Energy Info (EERE)

    ID-e < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools...

  11. RAPID/Roadmap/3-ID-e | Open Energy Information

    Open Energy Info (EERE)

    ID-e < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools...

  12. Disruption of Particle Detector Electronics by Beam Generated EMI

    SciTech Connect (OSTI)

    Bower, G.; Sugimoto, Y.; Sinev, N.; Arnold, R.; Woods, M.; /SLAC

    2007-06-27

    The possibility that radio frequency beam generated electromagnetic interference (EMI) could disrupt the operation of particle detector electronics has been of some concern since the inception of short pulse electron colliders more than 30 years ago [1]. Some instances have been reported where this may have occurred but convincing evidence has not been available. This possibility is of concern for the International Linear Collider (ILC). We have conducted test beam studies demonstrating that electronics disruption does occur using the vertex detector electronics (VXD) from the SLD detector which took data at the SLC at SLAC. We present the results of those tests, and we describe the need for EMI standards for beam and detector instrumentation in the IR region at the ILC.

  13. U. S. Attic Grsrgy 'bmiss~o3 U. S. Atomic lb-al-w CamLf3sion December 27, S.957

    Office of Legacy Management (LM)

    a . - 3 U. S. Attic Grsrgy 'bmiss~o3 U. S. Atomic lb-al-w CamLf3sion December 27, S.957

  14. Vehicle Technologies Office Merit Review 2015: High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of EVs

    Broader source: Energy.gov [DOE]

    Presentation given by Hyundai at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high efficiency, low EMI and...

  15. Vehicle Technologies Office Merit Review 2014: High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of EVs

    Broader source: Energy.gov [DOE]

    Presentation given by Hyundai at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high efficiency, low EMI and...

  16. THE WIRED SURVEY. IV. NEW DUST DISKS FROM THE McCOOK and SION WHITE DWARF CATALOG

    SciTech Connect (OSTI)

    Hoard, D. W.; Wachter, Stefanie; Debes, John H.; Leisawitz, David T.; Cohen, Martin

    2013-06-10

    We have compiled photometric data from the Wide-field Infrared Survey Explorer All Sky Survey and other archival sources for the more than 2200 objects in the original McCook and Sion Catalog of Spectroscopically Identified White Dwarfs. We applied color-selection criteria to identify 28 targets whose infrared spectral energy distributions depart from the expectation for the white dwarf (WD) photosphere alone. Seven of these are previously known WDs with circumstellar dust disks, five are known central stars of planetary nebulae, and six were excluded for being known binaries or having possible contamination of their infrared photometry. We fit WD models to the spectral energy distributions of the remaining ten targets, and find seven new candidates with infrared excess suggesting the presence of a circumstellar dust disk. We compare the model dust disk properties for these new candidates with a comprehensive compilation of previously published parameters for known WDs with dust disks. It is possible that the current census of WDs with dust disks that produce an excess detectable at K-band and shorter wavelengths is close to complete for the entire sample of known WDs to the detection limits of existing near-IR all-sky surveys. The WD dust disk candidates now being found using longer wavelength infrared data are drawn from a previously underrepresented region of parameter space, in which the dust disks are overall cooler, narrower in radial extent, and/or contain fewer emitting grains.

  17. Task 4 - EMI/RFI Issues Potentially Impacting Electromagnetic Compatibility of I&C Systems (NRCHQ6014D0015)

    SciTech Connect (OSTI)

    Wood, Richard Thomas; Ewing, Paul D.

    2015-05-01

    The U.S. Nuclear Regulatory Commission’s (NRC’s) regulations in Part 50, “Domestic Licensing of Production and Utilization Facilities,” of Title 10 of the Code of Federal Regulations (10 CFR Part 50) state that structures, systems, and components important to safety in a nuclear power plant are to be designed to accommodate the effects of environmental conditions (i.e., remain functional under all postulated service conditions) and that design control measures such as testing are to be used to check the adequacy of design. Regulatory Guide (RG) 1.180 was developed to provide guidance to licensees and applicants on methods acceptable to the NRC staff for complying with the NRC’s regulations on design, installation, and testing practices for addressing the effects of electromagnetic and radio-frequency interference (EMI/RFI) and power surges on safety-related instrumentation and control (I&C) systems. The first revision of RG 1.180 was issued in January 2000 and a second revision was issued in October 2003*. The second revision differed from the first revision in endorsing Military Standard (MIL-STD)-461E and the International Electrotechnical Commission (IEC) Standard (Std) 61000 series of EMI/RFI test methods, extending the guidance to cover signal line testing, incorporating frequency ranges where portable communications devices are experiencing increasing use, and relaxing the operating envelopes (test levels) when experience and confirmatory research warranted. It also offered exemptions from specific test criteria based on technical considerations such as plant conditions and the intended location of the safety-related I&C equipment. Since the last revision, new requirements have been identified, associated RGs have been created and updated, and additional industry guidance has been developed. Additionally, the operational environment has changed with the increase in wireless communication technology for both personal (smartphone) and industrial

  18. Hydropower Vision Chapter 1: Introducing the Hydropower Vision

    Broader source: Energy.gov (indexed) [DOE]

    ... valuation of system-wide grid reliability and stability services; and recognition and valuation of societal benefits from avoided power-sector air pollution and GHG emis- sions. ...

  19. Categorical ExcluSIon Determination Forn1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    exercises and simulation I8lB 1.3 * Routine maintenance and custodial services DB 1,4 * Air conditioning installation for existing equipment DB 1.5 Cooling water system...

  20. 2-ID-E

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    General Users. For example, in collaboration with G. Woloschak et al, we have looked at TiO2-DNA nanocomposites in mammalian cells 1; B. Twining et al investigate trace elements...

  1. CategorIcal ExcluSIon Determination 1,'orn1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Guidelines OA 14 - Approval of technical exchange arrangements OA 15 - International umbrella agreements for energy R&D Facility Operations DB 1.2 - Training exercises and...

  2. Categ orical ExcluSIon DetermInation Fornl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Guidelines OA 14 - Approval of technical exchange arrangements DAIS - International umbrella agreements for energy R&D Facility Operations DB 1.2 - Training exercises and...

  3. CategorIcal ExcluSIon DetermInation Fornl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Guidelines OA I 4 - Approval of technical exchange arrangements DAIS - International umbrella agreements for energy R&D Facility Operations DB 1.2 - Training exercises and...

  4. Sion Power Corp formerly Moltech Corp | Open Energy Information

    Open Energy Info (EERE)

    Sector: Vehicles Product: Tucson, Arizona-based privately held developer of thin-film lithium-sulfur rechargeable batteries for propelling vehicles and other high energy-density...

  5. Emergency Management Issues Special Interest Group (EMI SIG)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    & Products page. DOE News Information from DOENA-41 FAQs on DOE O 151.1 Emergency Management Updates Emergency Management Guides Emergency Management Accreditation Guide...

  6. Full tape thickness feature conductors for EMI structures

    DOE Patents [OSTI]

    Peterson, Kenneth A.; Knudson, Richard T.; Smith, Frank R.; Barner, Gregory

    2014-06-10

    Generally annular full tape thickness conductors are formed in single or multiple tape layers, and then stacked to produce an annular solid conductive wall for enclosing an electromagnetic isolation cavity. The conductors may be formed using punch and fill operations, or by flowing conductor-containing material onto the tape edge surfaces that define the interior sidewalls of the cavity.

  7. Using EMI for Electrical Energy Disaggregation in the Home

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    5 12% 9.2% 8.4% 6.8% 3.8% Enhanced Billing Web Based Daily Feedback Realtime Feedback ... 5 12% 9.2% 8.4% 6.8% 3.8% Enhanced Billing Web Based Daily Feedback Realtime Feedback ...

  8. https://empcs.nv.doe.gov/emis2/fa/pg/FFACO.Obligations_Commitments...

    National Nuclear Security Administration (NNSA)

    The NDEP will provide comments regarding issues on the CAU 98 CAIP and on the Nye County drilling program. Ongoing: Comments on the CAIP were received in a letter dated April 2,...

  9. High-Density EMI Filter Design for DC-Fed Motor Drives

    SciTech Connect (OSTI)

    Lai, Rixin; Maillet, Yoann; Wang, Shuo; Wang, Fei; Burgos, Rolando; Boroyevich, Dushan

    2010-01-01

    This paper presents strategies to reduce both differential-mode (DM) and common-mode (CM) noise using a passive filter in a dc-fed motor drive. The paper concentrates on the type of grounding and the components to optimize filter size and performance. Grounding schemes, material comparison between ferrite and nanocrystalline cores, and a new integrated filter structure are presented. The integrated structure maximizes the core window area and increases the leakage inductance by integrating both CM and DM inductances onto one core. Small-signal and large-signal experiments validate the structure, showing it to have reduced filter size and good filtering performance when compared with standard filters at both low and high frequencies.

  10. Argonne's Michael Wang talks about the GREET Model for reducing vehicle emi

    ScienceCinema (OSTI)

    Michael Wang

    2013-06-05

    To fully evaluate energy and emission impacts of advanced vehicle technologies and new transportation fuels, the fuel cycle from wells to wheels and the vehicle cycle through material recovery and vehicle disposal need to be considered. Sponsored by the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE), Argonne has developed a full life-cycle model called GREET (Greenhouse gases, Regulated Emissions, and Energy use in Transportation). It allows researchers and analysts to evaluate various vehicle and fuel combinations on a full fuel-cycle/vehicle-cycle basis. The first version of GREET was released in 1996. Since then, Argonne has continued to update and expand the model. The most recent GREET versions are the GREET 1 2012 version for fuel-cycle analysis and GREET 2.7 version for vehicle-cycle analysis.

  11. High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of EVs

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  12. Vehicle Technologies Office Merit Review 2016: High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of EVs

    Broader source: Energy.gov [DOE]

    Presentation given by Hyundai at the 2016 DOE Vehicle Technologies Office and Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting about Vehicle Systems

  13. Browse by Discipline -- E-print Network Subject Pathways: Biotechnolog...

    Office of Scientific and Technical Information (OSTI)

    J K L M N O P Q R S T U V W X Y Z Ide, Kayo (Kayo Ide) - Department of Atmospheric and Oceanic Science, University of Maryland at College Park Ide, Kayo (Kayo Ide) - Department of ...

  14. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Site for the Web Site for the I I ndirect and ndirect and S S emi emi - - D D irect irect A A erosol erosol C C ampaign ampaign (ISDAC) (ISDAC) Jason Tomlinson Pacific Northwest ...

  15. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

    SciTech Connect (OSTI)

    Deprez-Poulain, Rebecca; Hennuyer, Nathalie; Bosc, Damien; Liang, Wenguang G.; Enée, Emmanuelle; Marechal, Xavier; Charton, Julie; Totobenazara, Jane; Berte, Gonzague; Jahklal, Jouda; Verdelet, Tristan; Dumont, Julie; Dassonneville, Sandrine; Woitrain, Eloise; Gauriot, Marion; Paquet, Charlotte; Duplan, Isabelle; Hermant, Paul; Cantrelle, François- Xavier; Sevin, Emmanuel; Culot, Maxime; Landry, Valerie; Herledan, Adrien; Piveteau, Catherine; Lippens, Guy; Leroux, Florence; Tang, Wei-Jen; van Endert, Peter; Staels, Bart; Deprez, Benoit

    2015-09-23

    Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer’s disease and type-2 diabetes. As the major insulin-degrading protease, IDE is a candidate drug target in diabetes. Here we have used kinetic target-guided synthesis to design the first catalytic site inhibitor of IDE suitable for in vivo studies (BDM44768). Crystallographic and small angle X-ray scattering analyses show that it locks IDE in a closed conformation. Among a panel of metalloproteases, BDM44768 selectively inhibits IDE. Acute treatment of mice with BDM44768 increases insulin signalling and surprisingly impairs glucose tolerance in an IDE-dependent manner. These results confirm that IDE is involved in pathways that modulate short-term glucose homeostasis, but casts doubt on the general usefulness of the inhibition of IDE catalytic activity to treat diabetes.

  16. Yiii%sz Rockwell

    Office of Legacy Management (LM)

    these activities we were known as the Atomics International Divi- sion of North American Aviation, Inc. In September 1962 we shipped 409 kilograms of uranium enriched to...

  17. Property:NumberOfLowEmissionDevelopmentStrategiesExamples | Open...

    Open Energy Info (EERE)

    sionDevelopmentStrategiesExamples Property Type Number Retrieved from "http:en.openei.orgwindex.php?titleProperty:NumberOfLowEmissionDevelopmentStrategiesExamples&oldid323715...

  18. Improved DC Gun Insulator Assembly

    SciTech Connect (OSTI)

    Sah, R.; Dudas, A.; Neubauer, M. L.; Poelker, M.; Surles-Law, K. E.L.

    2010-05-23

    Many user fa­cil­i­ties such as syn­chrotron ra­di­a­tion light sources and free elec­tron lasers re­quire ac­cel­er­at­ing struc­tures that sup­port elec­tric fields of 10-100 MV/m, es­pe­cial­ly at the start of the ac­cel­er­a­tor chain where ce­ram­ic in­su­la­tors are used for very high gra­di­ent DC guns. These in­su­la­tors are dif­fi­cult to man­u­fac­ture, re­quire long com­mis­sion­ing times, and often ex­hib­it poor re­li­a­bil­i­ty. Two tech­ni­cal ap­proach­es to solv­ing this prob­lem will be in­ves­ti­gat­ed. First­ly, in­vert­ed ce­ram­ics offer so­lu­tions for re­duced gra­di­ents be­tween the elec­trodes and ground. An in­vert­ed de­sign will be pre­sent­ed for 350 kV, with max­i­mum gra­di­ents in the range of 5-10 MV/m. Sec­ond­ly, novel ce­ram­ic man­u­fac­tur­ing pro­cess­es will be stud­ied, in order to pro­tect triple junc­tion lo­ca­tions from emis­sion, by ap­ply­ing a coat­ing with a bulk re­sis­tiv­i­ty. The pro­cess­es for cre­at­ing this coat­ing will be op­ti­mized to pro­vide pro­tec­tion as well as be used to coat a ce­ram­ic with an ap­pro­pri­ate gra­di­ent in bulk re­sis­tiv­i­ty from the vac­u­um side to the air side of an HV stand­off ce­ram­ic cylin­der. Ex­am­ple in­su­la­tor de­signs are being com­put­er mod­elled, and in­su­la­tor sam­ples are being man­u­fac­tured and test­ed

  19. ORISS Isomer and Isobar Spectrometer and Separator for Study...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    50% * Chemistry independent * Transportable * Cost effective ... use Multi-pass Time of Flight principle 5 EMIS 2007 Multi-pass Time-of-Flight system: concept MTOF...

  20. ETA-HTP09 - Measurement and Evaluation of Magnetic Fields (EMF...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Measurement and Evaluation of Magnetic Fields (EMF) and Electromagnetic Radiation (EMI) ... 3 6. Magnetic Field and Electromagnetic Radiation 6.1 Magnetic Field Measurement Procedure ...

  1. Microsoft Word - 25A2340 Continued

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Different varieties have applications in batteries, electrochemical capacitors, composites, high-frequency EMI shielding, and heat conduction. Still, the Silicon-coated version for ...

  2. u.s. DEPARTMENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    School of Mines Page lof3 STATE: CO PROJECf TITLE: ... modeling) , doOJment preparation (Including, but not ... alf emiSSions, or solid waste streams; (h) ...

  3. Energy Management and Information Systems, BBA Technical Team

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... offering Whole Building Level EMIS Benchmarking and Monthly Utility Bill Analysis ... 2014 Additional Funding: NA Budget History October 2012, FY2013 (past) FY2014 ...

  4. High Specific Activity Sn-117m by Post Irradiation Isotope Separation

    SciTech Connect (OSTI)

    DAuria, John

    2015-04-16

    ElectroMagnetic Isotope Separation (EMIS) is used in the production of enriched stable isotopes. We demonstrated the feasibility of using EMIS to produce medium Specific Activity 117mSm using high purity 116Sn target material irradiated in a high flux reactor.

  5. Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

    SciTech Connect (OSTI)

    Leissring, Malcolm A.; Malito, Enrico; Hedouin, Sabrine; Reinstatler, Lael; Sahara, Tomoko; Abdul-Hay, Samer O.; Choudhry, Shakeel; Maharvi, Ghulam M.; Fauq, Abdul H.; Huzarska, Malwina; May, Philip S.; Choi, Sungwoon; Logan, Todd P.; Turk, Benjamin E.; Cantley, Lewis C.; Manolopoulou, Marika; Tang, Wei-Jen; Stein, Ross L.; Cuny, Gregory D.; Selkoe, Dennis J.

    2010-09-20

    Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism, which is mediated primarily by insulin-degrading enzyme (IDE), a structurally and evolutionarily distinctive zinc-metalloprotease. Despite interest in pharmacological inhibition of IDE as an attractive anti-diabetic approach dating to the 1950s, potent and selective inhibitors of IDE have not yet emerged. We used a rational design approach based on analysis of combinatorial peptide mixtures and focused compound libraries to develop novel peptide hydroxamic acid inhibitors of IDE. The resulting compounds are {approx} 10{sup 6} times more potent than existing inhibitors, non-toxic, and surprisingly selective for IDE vis-a-vis conventional zinc-metalloproteases. Crystallographic analysis of an IDE-inhibitor complex reveals a novel mode of inhibition based on stabilization of IDE's 'closed,' inactive conformation. We show further that pharmacological inhibition of IDE potentiates insulin signaling by a mechanism involving reduced catabolism of internalized insulin. Conclusions/Significance: The inhibitors we describe are the first to potently and selectively inhibit IDE or indeed any member of this atypical zinc-metalloprotease superfamily. The distinctive structure of IDE's active site, and the mode of action of our inhibitors, suggests that it may be possible to develop inhibitors that cross-react minimally with conventional zinc-metalloproteases. Significantly, our results reveal that insulin signaling is normally regulated by IDE activity not only extracellularly but also within cells, supporting the longstanding view that IDE inhibitors could hold therapeutic value for the treatment of diabetes.

  6. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Deprez-Poulain, Rebecca; Hennuyer, Nathalie; Bosc, Damien; Liang, Wenguang G.; Enée, Emmanuelle; Marechal, Xavier; Charton, Julie; Totobenazara, Jane; Berte, Gonzague; Jahklal, Jouda; et al

    2015-09-23

    Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer’s disease and type-2 diabetes. As the major insulin-degrading protease, IDE is a candidate drug target in diabetes. Here we have used kinetic target-guided synthesis to design the first catalytic site inhibitor of IDE suitable for in vivo studies (BDM44768). Crystallographic and small angle X-ray scattering analyses show that it locks IDE in a closed conformation. Among a panel of metalloproteases, BDM44768 selectively inhibits IDE. Acute treatment of mice with BDM44768 increases insulin signalling and surprisinglymore » impairs glucose tolerance in an IDE-dependent manner. These results confirm that IDE is involved in pathways that modulate short-term glucose homeostasis, but casts doubt on the general usefulness of the inhibition of IDE catalytic activity to treat diabetes.« less

  7. SLA-74.0103 No For(:iqri

    Office of Scientific and Technical Information (OSTI)

    Antia ,craft b1issiJ.e (SIAM). A description of the optical system is included, and models of target radiant intensity, atmospheric transmis- sion, and background radiance...

  8. SECURING HARDWARE, SOFTWARE AND DATA

    Energy Savers [EERE]

    wish to thank Joree O'Neal and Rachel Smith for all their help and support with ... Lab; sion@cs.stonybrook.edu Smith, Sean; Dartmouth College; sws@cs.dartmouth.edu St. ...

  9. untitled

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... to model the effects of fast-neutron pulses on the gain ... sion's Office of New Reactors in performing license ... Tech Area 5 with a Sodium Reactor Fuel Debris ...

  10. LBL--29472 DE91

    Office of Scientific and Technical Information (OSTI)

    This work supported by the Director, Office 11 of Energy Research, Office of High Energy and Nuclear Physics, Nuclear Science Divi- sion, U. S. Department of Energy under con- ...

  11. Use Vapor Recompression to Recover Low-Pressure Waste Steam,...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Conduct a Pinch Analysis Based on the actual application, there may be other options to vapor recompres- sion. The industry best practice is to conduct a pinch analysis on the ...

  12. TRUTeamWorks 08-05-04

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waste Isolation Pilot Plant team Transportation and disposal ... engineer in the U.S. Naval Nuclear Propul- sion Program. ... To everyone else, thank you. John Gran The Safety Awareness ...

  13. X&h

    Office of Legacy Management (LM)

    ... 1945, effective as of the 1st day of Ray 1343, the partics hereto entered into ... JRZPRAS, said contract was tmnsferred to the Vnitcd States Atomic Energy Conn&sion ...

  14. Compliance, HQ GILMAD J&ILL STUDY

    Office of Legacy Management (LM)

    associated with the Ilanhattan Project andor early Atomic Energy Coaik5sion activities. ... Barium x-rays were pronounced in the corresponding x-ray spectra taken with the FIDLER ...

  15. HANFORD ADVISORY BOARD

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... DOE-ORP Barb Wise, MSA Emy Laija, EPA Dale McKenney, CHPRC Susan Hayman, EnviroIssues Marc Jewett, CHPRC Hillary Johnson, EnviroIssues Janice Williams, CHPRC Dale Bignell, WCH

  16. Final Meeting Summary Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Hillary Johnson, EnviroIssues, suggested bringing the topic of advice responses and timely ... Addington, EnviroIssues Emy Laija, EPA Hillary Johnson, EnviroIssues Mark Freshley, PNNL ...

  17. arm_stm_2007_revercomb_poster.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - 2006 RRTM flux (AIRS Ts, emis) CERES comparison RRTM minus CERES Wm 2 Wm 2 Clear Sky TOA Flux from GOES and Aqua CERES Clear Sky TOA Flux GOES minus CERES * Mean: +5.5 Wm...

  18. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Maki ; Takagi, Noriaki, E-mail: n-takagi@k.u-tokyo.ac.jp ; Minamitani, Emi ; Kim, ... unique electronic structure of multi-spins and multi-orbitals when attached to Au(111). ...

  19. CX-009333: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of Electric Vehicles CX(s) Applied: B3.6, B5.23 Date: 09/25/2012 Location(s): California Offices(s): National Energy Technology Laboratory

  20. CX-009334: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of Electric Vehicles CX(s) Applied: B3.6, B5.23 Date: 09/25/2012 Location(s): Michigan Offices(s): National Energy Technology Laboratory

  1. MTV Utility Library

    Energy Science and Technology Software Center (OSTI)

    2008-02-29

    The MSV Java Utility Library contains software developed over many years for many sponsors. (This work is not a derivative of CB-EMIS), but rather support to the CB-EMIS software). Projects that have used and contributed to code in this library: CB-EMIS (PROTECT), BWIC, Fort Future, Teva, Integrated Oceans, ENKIMDU, RCW, JEMS, JWACS, EPA watershed, and many others. This library will continue to be used in other non-CB-EMIS related projects. The components include: Spatial components: Multi-coordinatemore » system spatial objects. 2D spatial indexing system, and polygon griding system. Data translation: Allows import and export of file based data to and from object oriented systems. Multi-platform data streams: Allows platform specific data streams to operate on any support platform. Other items include printing, custom GUI components, support for NIMA Raster Product Format, program logging utilities and others.« less

  2. NFPA hazardous classifications and compliance regarding the electromagnetic induction probe

    SciTech Connect (OSTI)

    Vargo, G.F.; Stokes, T.I., Westinghouse Hanford

    1996-08-13

    This document discusses how the Electromagnetic Induction probe complies with the hazardous locations discussed for the Surface Moisture Measurement System (SMMS). The EMI probe head was designed to interchange with the neutron probe of the SMMS.

  3. CX-013474: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of Electric Vehicles CX(s) Applied: A9Date: 03/13/2015 Location(s): IllinoisOffices(s): National Energy Technology Laboratory

  4. CX-013750: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    High Efficiency, Low EMI and Positioning Tolerant Wireless Charging of EVs CX(s) Applied: A9Date: 03/13/2015 Location(s): IllinoisOffices(s): National Energy Technology Laboratory

  5. Final Meeting Summary Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE- ORPNorth Wind Andrea Prignano, WRPS Dieter Bohrmann, Ecology Rich Marshall, DOE-ORPNorth Wind Rachel Baron, HoANW (phone) Emy Laija, EPA Pedro de la Torrez, student...

  6. Application of pyroelectric crystal and ionic liquid to the production of metal compounds

    SciTech Connect (OSTI)

    Imashuku, Susumu; Imanishi, Akira; Kawai, Jun

    2013-04-19

    Zinc fluoride (ZnF{sub 2}) was deposited on a silicon substrate by changing temperature of a pyroelectric crystal of LiTaO{sub 3} on which ionic liquid (EMI-Tf{sub 2}N) containing zinc ions was dripped at 1 Pa. ZnF{sub 2} was also obtained by bombarding argon ions on EMI-Tf{sub 2}N containing zinc ions. From these results, it is concluded that EMI-Tf{sub 2}N containing zinc ions on the LiTaO{sub 3} crystal was evaporated on the silicon substrate by changing temperature of the LiTaO{sub 3} crystal in vacuum and that the evaporated EMI-Tf{sub 2}N containing metal zinc ions was decomposed to ZnF{sub 2} by the bombardment of electrons accelerated by the electric field between the LiTaO{sub 3} crystal and the silicon substrate.

  7. Final Meeting Summary Page 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... DOE does record searches, radiological surveys, and conducts walk-downs of those areas to ... DOE-RL Emy Laija, EPA Alex Norgard, CTUIR Jim Laity (phone) DOE-HQ Chris Guzzetti, EPA ...

  8. Time-Resolved Research (XSD-TRR) | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at 8-ID-E is focused on correlating the structure of OPV thin films with light-harvesting performance and probing defects in self-assembled block copolymers with applications...

  9. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ), a ceramic-metal material showing a highmore electrical conductivity and ther mal stability, which is known to be most effectively used as anodes for solid ox ide fuel cells. ...

  10. PDSF User Meeting 09-01-15.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 --- Past Outages * 81215 ( 2 d ays): N ERSC s ystem w ide o utage f rom power e vent Planned Outages * None Several PDSF Nodes Moved to CRT * About 3 00 c ores w ork o f c ...

  11. Bonneville Power Administration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    correspondence with the Agenc y about your request. You have renuested the following; Prop ide copies of all A gcmic I)ccision Frameworks related to the Network Open Season 2009...

  12. TRANSIMS Interface Development

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    transims TRANSIMS Interface Development TRACC RESEARCH Computational Fluid Dynamics Computational Structural Mechanics Transportation Systems Modeling TRANSIMS Studio (Figure 1) has been developed by TRACC for the TRANSIMS community as part of the TRANSIMS Open Source project. It provides an integrated development environment (IDE) for TRANSIMS by combining a number of components that work seamlessly with each other. The visible part of the IDE is the graphical user interface (GUI) that allows

  13. Identification of the Allosteric Regulatory Site of Insulysin

    SciTech Connect (OSTI)

    Noinaj, Nicholas; Bhasin, Sonia K.; Song, Eun Suk; Scoggin, Kirsten E.; Juliano, Maria A.; Juliano, Luiz; Hersh, Louis B.; Rodgers, David W.

    2012-05-25

    Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the A{beta} peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer, exhibits allosteric kinetics, being activated by both small substrate peptides and polyphosphates such as ATP. The crystal structure of a catalytically compromised mutant of IDE has electron density for peptide ligands bound at the active site in domain 1 and a distal site in domain 2. Mutating residues in the distal site eliminates allosteric kinetics and activation by a small peptide, as well as greatly reducing activation by ATP, demonstrating that this site plays a key role in allostery. Comparison of the peptide bound IDE structure (using a low activity E111F IDE mutant) with unliganded wild type IDE shows a change in the interface between two halves of the clamshell-like molecule, which may enhance enzyme activity by altering the equilibrium between closed and open conformations. In addition, changes in the dimer interface suggest a basis for communication between subunits. Our findings indicate that a region remote from the active site mediates allosteric activation of insulysin by peptides. Activation may involve a small conformational change that weakens the interface between two halves of the enzyme.

  14. Surface moisture measurement system electromagnetic induction probe calibration technique

    SciTech Connect (OSTI)

    Crowe, R.D., Westinghouse Hanford

    1996-07-08

    The Surface Moisture Measurement System (SMMS) is designed to measure the moisture concentration near the surfaces of the wastes located in the Hanford Site tank farms. This document describes a calibration methodology to demonstrate that the Electromagnetic Induction (EMI) moisture probe meets relevant requirements in the `Design Requirements Document (DRD) for the Surface Moisture Measurement System.` The primary purpose of the experimental tests described in this methodology is to make possible interpretation of EMI in-tank surface probe data to estimate the surface moisture.

  15. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flight Planning for the Flight Planning for the I I ndirect and ndirect and S S emi emi - - D D irect irect A A erosol erosol C C ampaign ampaign (ISDAC) (ISDAC) Jason Tomlinson Pacific Northwest National Laboratory ARM Science Team Meeting March 11 th , 2008 Norfolk, VA * ISDAC will occur from April 1 st to April 30 th * EC/NRC Convair Overview Explanation Examples 1 Overview 1 Overview Explanation Examples * ISDAC will occur from April 1 st to April 30 th * EC/NRC Convair - Full suite of

  16. Membership Finland

    ScienceCinema (OSTI)

    None

    2011-04-25

    Le DG C.Rubbia et la vice présidente du conseil du Cern souhaite la bienvenue à l'adhésion de la Finlande, comme 15me membre du Cern depuis le 1. janvier 1991 en présence du secrétaire generale et de l'ambassadeur

  17. DOE/EIS-0132-F United States Department ...

    Broader source: Energy.gov (indexed) [DOE]

    ... T h e U . S. N u c l ea r R eg u l a to ry C omi s sion ( NR C ) wi l l c o n c u r in t h ... E . 2 . 1 3 ) . The dRAP sumary, however, omi ts hydra u l i c condu c t i v i ty v a l ...

  18. Press conference

    ScienceCinema (OSTI)

    None

    2011-04-25

    Exposés de plusieurs intervenants de la direction et du conseil, comme le Prof.Ramsey, président du conseil sur l'adhésion récente de la Finlande et le "boom" scientifique des pays de l'est.

  19. Title Geographic Distribution. Eumeces gilberti Rubricaudatus...

    National Nuclear Security Administration (NNSA)

    RL 10,0.3 km E ofCo.RoadDD(Sec.33,T52N.R26W).16July 1989. F. E. Blake & D. D. Smith. ... Conserv. Publ., 368 pp.). Submitted by DONALD D. SMITH, Divi- sion of Allergy & ...

  20. C. SIrENET

    Office of Legacy Management (LM)

    m. 61 12!?1/37 C. SIrENET PR jwnlrn RB-JUTA,000LffiBe kw4LV ID TM Ca#lsSION KSII~ ELECTRIC CL@'. VlTiiuFsf MRCS PL#il CMWIE-IELLa CYcLOTml FK

  1. COOLANT STABILIZED WITH KETONE

    DOE Patents [OSTI]

    Burr, J.G.; Strong, J.D.

    1961-11-21

    sion). U. S. Patent 3,009.88l. Nov. 2l, l06l. A method is given for inhibiting radiolytic damage to a polyphenyl composition undergoing nuclear irradiation, the polyphenyl composition initially consisting essentially of polyphenyls having 2 to 4 phenyl rings. The method comprises adding approximately 5 mole% anthraquinone to the polyphenyl composition. (AEC)

  2. Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

    SciTech Connect (OSTI)

    Charton, Julie; Dumont, Julie; Liang, Wenguang G.; Leroux, Florence; Deprez, Benoit

    2015-10-30

    Insulin degrading enzyme (IDE) is a zinc metalloprotease that degrades small amyloid peptides such as amyloid-â and insulin. So far the dearth of IDE-specific pharmacological inhibitors impacts the understanding of its role in the physiopathology of Alzheimer's disease, amyloid-â clearance, and its validation as a potential therapeutic target. Hit 1 was previously discovered by high-throughput screening. Here we describe the structure-activity study, that required the synthesis of 48 analogues. We found that while the carboxylic acid, the imidazole and the tertiary amine were critical for activity, the methyl ester was successfully optimized to an amide or a 1,2,4-oxadiazole. Along with improving their activity, compounds were optimized for solubility, lipophilicity and stability in plasma and microsomes. The docking or co-crystallization of some compounds at the exosite or the catalytic site of IDE provided the structural basis for IDE inhibition. The pharmacokinetic properties of best compounds 44 and 46 were measured in vivo. As a result, 44 (BDM43079) and its methyl ester precursor 48 (BDM43124) are useful chemical probes for the exploration of IDE's role.

  3. Chemical Biological Emergency Management Information System

    Energy Science and Technology Software Center (OSTI)

    2004-06-15

    CB-EMIS is designed to provide information and analysis to transit system operators and emergency responders in the event of a chemical attack on a subway system. The software inforporates detector data, video images, train data, meteorological data, and above- and below-ground plume dispersion models, hight of the liquid level.

  4. Commercial Building Energy Baseline Modeling Software: Performance Metrics and Method Testing with Open Source Models and Implications for Proprietary Software Testing

    SciTech Connect (OSTI)

    Price, Phillip N.; Granderson, Jessica; Sohn, Michael; Addy, Nathan; Jump, David

    2013-09-01

    The overarching goal of this work is to advance the capabilities of technology evaluators in evaluating the building-level baseline modeling capabilities of Energy Management and Information System (EMIS) software. Through their customer engagement platforms and products, EMIS software products have the potential to produce whole-building energy savings through multiple strategies: building system operation improvements, equipment efficiency upgrades and replacements, and inducement of behavioral change among the occupants and operations personnel. Some offerings may also automate the quantification of whole-building energy savings, relative to a baseline period, using empirical models that relate energy consumption to key influencing parameters, such as ambient weather conditions and building operation schedule. These automated baseline models can be used to streamline the whole-building measurement and verification (M&V) process, and therefore are of critical importance in the context of multi-measure whole-building focused utility efficiency programs. This report documents the findings of a study that was conducted to begin answering critical questions regarding quantification of savings at the whole-building level, and the use of automated and commercial software tools. To evaluate the modeling capabilities of EMIS software particular to the use case of whole-building savings estimation, four research questions were addressed: 1. What is a general methodology that can be used to evaluate baseline model performance, both in terms of a) overall robustness, and b) relative to other models? 2. How can that general methodology be applied to evaluate proprietary models that are embedded in commercial EMIS tools? How might one handle practical issues associated with data security, intellectual property, appropriate testing ‘blinds’, and large data sets? 3. How can buildings be pre-screened to identify those that are the most model-predictable, and therefore those

  5. The Top Ten Things I Learned at the Ambassador Retreat | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy The Top Ten Things I Learned at the Ambassador Retreat The Top Ten Things I Learned at the Ambassador Retreat September 4, 2014 - 1:36pm Addthis Britt Ide President, Ide Law & Strategy, PLLC, C3E Ambassador Editor's Note: This blog is cross-posted from the Clean Energy, Education, Empowerment (C3E) online network, www.c3enet.org. Learn more about C3E here. I am delighted to be serving as a C3E Ambassador. The retreat in July was my first and I learned a ton and deeply enjoyed

  6. Quantum photonics hybrid integration platform

    SciTech Connect (OSTI)

    Murray, E.; Floether, F. F.; Ellis, D. J. P.; Meany, T.; Bennett, A. J. Shields, A. J.; Lee, J. P.; Griffiths, J. P.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A.

    2015-10-26

    Fundamental to integrated photonic quantum computing is an on-chip method for routing and modulating quantum light emission. We demonstrate a hybrid integration platform consisting of arbitrarily designed waveguide circuits and single-photon sources. InAs quantum dots (QD) embedded in GaAs are bonded to a SiON waveguide chip such that the QD emission is coupled to the waveguide mode. The waveguides are SiON core embedded in a SiO{sub 2} cladding. A tuneable Mach Zehnder interferometer (MZI) modulates the emission between two output ports and can act as a path-encoded qubit preparation device. The single-photon nature of the emission was verified using the on-chip MZI as a beamsplitter in a Hanbury Brown and Twiss measurement.

  7. Using electromagnetic sensors (magnetometers and dielectrometers) to detect corrosion beneath and moisture within paint coatings on aircraft

    SciTech Connect (OSTI)

    Goldfine, N.; Greig, N.A.

    1994-12-31

    Current nondestructive inspection (NDI) techniques, such as visual inspection, ultrasonic testing, and eddy current testing, do not adequately detect the early stages of hidden corrosion under paint in critical structures such as airframes. This paper proposes a sensor system that uses meandering winding magnetometers (MWMs) and interdigital electrode dielectrometers (IDEDs) to detect hidden corrosion under paint and to measure the depth of moisture within barrier paint coatings. The MWM uses magnetic fields and inductive coupling to measure profiles of the properties of conducting media (such as the reduced conductivity near a metal surface caused by an oxygen diffusion layer resulting from early-stage corrosion). The IDED uses electric fields and capacitive coupling to measure the properties of multiple-layered insulating media, such as paint or the metal oxides formed during corrosion. MWM and IDED sensor designs permit Cartesian coordinate modal continuum modeling, which takes advantage of sensor geometries to provide more precise response predictions than are generally possible with conventional eddy current probes. Data are presented to describe the limitations of current NDI techniques, address the need for a new type of corrosion-detection system and discuss the underlying theory and potential of using MWMs and IDEDs to detect corrosion.

  8. CX-011861: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Easts Ide Renovation Project Zone 1-Revision (T-1-11) CX(s) Applied: B2.5, B5.2, B5.4, B5.5 Date: 03/13/2014 Location(s): Wyoming Offices(s): RMOTC

  9. Northeast

    Broader source: Energy.gov (indexed) [DOE]

    The N ortheast c onsists o f a n umber o f l arge a nd d ensely populated u rban a nd i ndustrial a reas, a s w ell a s w ide--- ranging r ural a reas a nd d eciduous f orestland. ...

  10. NERSC_ASCR_Requirements_Review-1.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    15, 2014 LBNL Outline * Goal: i mproved w idely u sed l inear a lgebra (and o ther) l ... t o a Nain n eeded a ccuracy * What H WSW f eatures d o w e n eed t o d o t his? ...

  11. CX-011863: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    Easts Ide Renovation Project Zone 1-Revision (T-1-11) CX(s) Applied: B2.5, B5.2, B5.4, B5.5 Date: 03/13/2014 Location(s): Wyoming Offices(s): RMOTC

  12. NREL Develops ZnSiP2 for Silicon-Based Tandem Solar Cells (Fact Sheet), NREL Highlights in Research & Development, NREL (National Renewable Energy Laboratory)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Combining an Earth-abundant chalcopyrite with a silicon layer could significantly boost conversion efficiency above that of single-junction silicon solar cells. A current technological challenge in photovoltaics (PV) is to implement a lattice-matched, optically efficient material to be used in conjunction with silicon for tandem PV cells. III-V materials currently hold the world-record conver- sion efficiencies for both single- and multijunction cells. Researchers at the National Renewable

  13. OSTIblog Articles in the Bayesian Inference Topic | OSTI, US Dept of Energy

    Office of Scientific and Technical Information (OSTI)

    Office of Scientific and Technical Information Bayesian Inference Topic The Reverend Thomas Bayes by Kathy Chambers 06 Nov, 2013 in Products and Content 13432 bayesPicture.jpg The Reverend Thomas Bayes Read more about 13432 During the 1700's, the Reverend Thomas Bayes was a nonconformist minister at the Mount Sion Chapel in Tunbridge Wells, UK, about 40 miles southeast of central London. Having studied both theology and logic at the University of Edinburgh, he was also a mathematician and

  14. LANSCE Focus

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Focus Nuclear science observations and opportunities at the Los Alamos Neutron Science Center Colleagues, This special Focus issue highlights a set of nuclear physics capabilities at the Los Alamos Neutron Science Center (LANSCE) serving Los Alamos National Laboratory's national security mis- sion and the global scientific user community. With a total of 10 flight paths, LANSCE pro- vides the opportunity to perform experiments with low- to high-energy neutron sources and high-energy proton

  15. A low-power pressure-and temperature-programmed separation system for a micro gas chromatograph.

    SciTech Connect (OSTI)

    Sacks, Richard D. (University of Michigan, Ann Arbor, MI); Robinson, Alex Lockwood (Advanced Sensor Technologies, Albuquerque, NM); Lambertus, Gordon R. (University of Michigan, Ann Arbor, MI); Potkay, Joseph A. (University of Michigan, Ann Arbor, MI); Wise, Kensall D. (University of Michigan, Ann Arbor, MI)

    2006-10-01

    This thesis presents the theory, design, fabrication and testing of the microvalves and columns necessary in a pressure- and temperature-programmed micro gas chromatograph ({micro}GC). Two microcolumn designs are investigated: a bonded Si-glass column having a rectangular cross section and a vapor-deposited silicon oxynitride (Sion) column having a roughly circular cross section. Both microcolumns contain integrated heaters and sensors for rapid, controlled heating. The 3.2 cm x 3.2 cm, 3 m-long silicon-glass column, coated with a non-polar polydimethylsiloxane (PDMS) stationary phase, separates 30 volatile organic compounds (VOCs) in less than 6 min. This is the most efficient micromachined column reported to date, producing greater than 4000 plates/m. The 2.7 mm x 1.4 mm Sion column eliminates the glass sealing plate and silicon substrate using deposited dielectrics and is the lowest power and fastest GC column reported to date; it requires only 11 mW to raise the column temperature by 100 C and has a response time of 11s and natural temperature ramp rate of 580 C/min. A 1 m-long PDMS-coated Sion microcolumn separates 10 VOCs in 52s. A system-based design approach was used for both columns.

  16. The application of wavelet shrinkage denoising to magnetic Barkhausen noise measurements

    SciTech Connect (OSTI)

    Thomas, James

    2014-02-18

    The application of Magnetic Barkhausen Noise (MBN) as a non-destructive method of defect detection has proliferated throughout the manufacturing community. Instrument technology and measurement methodology have matured commensurately as applications have moved from the R and D labs to the fully automated manufacturing environment. These new applications present a new set of challenges including a bevy of error sources. A significant obstacle in many industrial applications is a decrease in signal to noise ratio due to (i) environmental EMI and (II) compromises in sensor design for the purposes of automation. The stochastic nature of MBN presents a challenge to any method of noise reduction. An application of wavelet shrinkage denoising is proposed as a method of decreasing extraneous noise in MBN measurements. The method is tested and yields marked improvement on measurements subject to EMI, grounding noise, and even measurements in ideal conditions.

  17. Stable Isotope Enrichment Capabilities at ORNL

    SciTech Connect (OSTI)

    Egle, Brian; Aaron, W Scott; Hart, Kevin J

    2013-01-01

    The Oak Ridge National Laboratory (ORNL) and the US Department of Energy Nuclear Physics Program have built a high-resolution Electromagnetic Isotope Separator (EMIS) as a prototype for reestablishing a US based enrichment capability for stable isotopes. ORNL has over 60 years of experience providing enriched stable isotopes and related technical services to the international accelerator target community, as well as medical, research, industrial, national security, and other communities. ORNL is investigating the combined use of electromagnetic and gas centrifuge isotope separation technologies to provide research quantities (milligram to several kilograms) of enriched stable isotopes. In preparation for implementing a larger scale production facility, a 10 mA high-resolution EMIS prototype has been built and tested. Initial testing of the device has simultaneously collected greater than 98% enriched samples of all the molybdenum isotopes from natural abundance feedstock.

  18. Power converter connection configuration

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Kehl, Dennis L.; Gettelfinger, Lee A.; Kaishian, Steven C.; Phillips, Mark G.; Radosevich, Lawrence D.

    2008-11-11

    EMI shielding is provided for power electronics circuits and the like via a direct-mount reference plane support and shielding structure. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support forms a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  19. Electromagnetic interference impact of the proposed emitters for the High Frequency Active Auroral Research Program (HAARP). Interim report

    SciTech Connect (OSTI)

    Robertshaw, G.A.; Snyder, A.L.; Weiner, M.M.

    1993-05-14

    The proposed HAARP emitters at the Gakona (Alaska) preferred site and at the Clear AFS (Alaska) alternative site are the Ionospheric Research Instrument (IRI), the Incoherent Scatter Radar (ISR), and the Vertical Incidence Sounder(VIS). The electromagnetic interference (EMI) impact of those emitters on receiving systems in the vicinity of the sites is estimated in this study. The results are intended for use as an input to the Air Force Environmental Impact Statement as part of the Environmental Impact Analysis Process.

  20. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Budget and Contracts Committee Chair 1 : Jerry Peltier 4 , Member Vice Chair 1 : Don Bouchey 4 , Member Committee Members 2 : Don Bouchey Jerry Peltier Gary Garnant Gerry Pollet Mike Korenko Ed Revell Susan Leckband 4 Gene Van Liew Ken Niles Unofficial Committee Members or Other Interested Parties 3 : Earl Fordham Steve Hudson 4 Facilitator: Cathy McCague 4 Agency and Technical Support: Kris Holmes 4 DOE-RL Randy Bradbury 4 Ecology Dieter Bohrmann DOE-ORP Emy Laija 4

  1. Involvement and Communication Committee.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health, Safety, Environmental Protection Chair 1 : Becky Holland 4 , Member Vice Chair 1 : Richard Bloom 4 , Alternate Committee Members 2 : Richard Bloom Becky Holland Antone Brooks Steve Hudson 4 Jan Catrell Bob Legard Sam Dechter Margery Swint Dirk Dunning Unofficial Committee Members or Other Interested Parties 3 : Pam Larsen Susan Leckband 4 Mike Priddy Facilitator: Cathy McCague 4 Agency & Technical Support: Kris Holmes 4 DOE-RL Randy Bradbury 4 Ecology Dieter Bohrmann 4 DOE-ORP Emy

  2. Digital I&C systems in nuclear power plants. Risk-screening of environmental stressors and a comparison of hardware unavailability with an existing analog system

    SciTech Connect (OSTI)

    Hassan, M.; Vesely, W.E.

    1998-01-01

    In this report, we present a screening study to identify environmental stressors for digital instrumentation and control (I&C) systems in a nuclear power plant (NPP) which can be potentially risk-significant, and compare the hardware unavailability of such a system with that of its existing analog counterpart. The stressors evaluated are temperature, humidity, vibration, radiation, electro-magnetic interference (EMI), and smoke. The results of risk-screening for an example plant, subject to some bounding assumptions and based on relative changes in plant risk (core damage frequency impacts of the stressors), indicate that humidity, EMI from lightning, and smoke can be potentially risk-significant. Risk from other sources of EMI could not be evaluated for a lack of data. Risk from temperature appears to be insignificant as that from the assumed levels of vibrations. A comparison of the hardware unavailability of the existing analog Safety Injection Actuation System (SIAS) in the example plant with that of an assumed digital upgrade of the system indicates that system unavailability may be more sensitive to the level of redundancy in elements of the digital system than to the environmental and operational variations involved. The findings of this study can be used to focus activities relating to the regulatory basis for digital I&C upgrades in NPPs, including identification of dominant stressors, data-gathering, equipment qualification, and requirements to limit the effects of environmental stressors. 30 refs., 8 figs., 26 tabs.

  3. Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control

    SciTech Connect (OSTI)

    Radulescu, Razvan T., E-mail: ratura@gmx.net [Molecular Concepts Research (MCR), Muenster (Germany); Duckworth, William C. [Department of Medicine, Phoenix VA Health Care System, Phoenix, AZ (United States)] [Department of Medicine, Phoenix VA Health Care System, Phoenix, AZ (United States); Levy, Jennifer L. [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States)] [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States); Fawcett, Janet, E-mail: janet.fawcett@va.gov [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States)] [Research Service, Phoenix VA Health Care System, Phoenix, AZ (United States)

    2010-04-30

    Previous investigations on proteasomal preparations containing insulin-degrading enzyme (IDE; EC 3.4.24.56) have invariably yielded a co-purifying protein with a molecular weight of about 110 kDa. We have now found both in MCF-7 breast cancer and HepG2 hepatoma cells that this associated molecule is the retinoblastoma tumor suppressor protein (RB). Interestingly, the amount of RB in this protein complex seemed to be lower in HepG2 vs. MCF-7 cells, indicating a higher (cytoplasmic) protein turnover in the former vs. the latter cells. Moreover, immunofluorescence showed increased nuclear localization of RB in HepG2 vs. MCF-7 cells. Beyond these subtle differences between these distinct tumor cell types, our present study more generally suggests an interplay between RB and IDE within the proteasome that may have important growth-regulatory consequences.

  4. Applications for ACTS Workshop Due June 24

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for ACTS Workshop Due June 24 Applications for ACTS Workshop Due June 24 June 1, 2012 by Francesca Verdier The 13th Workshop on the DOE Advanced Computational Software (ACTS) Collection, Scalable and Robust Computational Libraries and Tools for High-End Computing, will be held in Berkeley, CA, on August 14-17, 2012.ide range of applications and fields in computational sciences. The four-day workshop will include tutorials on the tools currently available in the collection, discussion sessions to

  5. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

    SciTech Connect (OSTI)

    Ren, Min; Guo, Qing; Guo, Liang; Lenz, Martin; Qian, Feng; Koenen, Rory R.; Xu, Hua; Schilling, Alexander B.; Weber, Christian; Ye, Richard D.; Dinner, Aaron R.; Tang, Wei-Jen

    2010-12-07

    Macrophage inflammatory protein-1 (MIP-1), MIP-1{alpha} (CCL3) and MIP-1{beta} (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1{alpha} and MIP-1{beta} form high-molecular-weight aggregates. Our crystal structures reveal that MIP-1 aggregation is a polymerization process and human MIP-1{alpha} and MIP-1{beta} form rod-shaped, double-helical polymers. Biophysical analyses and mathematical modelling show that MIP-1 reversibly forms a polydisperse distribution of rod-shaped polymers in solution. Polymerization buries receptor-binding sites of MIP-1{alpha}, thus depolymerization mutations enhance MIP-1{alpha} to arrest monocytes onto activated human endothelium. However, same depolymerization mutations render MIP-1{alpha} ineffective in mouse peritoneal cell recruitment. Mathematical modelling reveals that, for a long-range chemotaxis of MIP-1, polymerization could protect MIP-1 from proteases that selectively degrade monomeric MIP-1. Insulin-degrading enzyme (IDE) is identified as such a protease and decreased expression of IDE leads to elevated MIP-1 levels in microglial cells. Our structural and proteomic studies offer a molecular basis for selective degradation of MIP-1. The regulated MIP-1 polymerization and selective inactivation of MIP-1 monomers by IDE could aid in controlling the MIP-1 chemotactic gradient for immune surveillance.

  6. Document

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    29 CFR Ch. XIV (7-1-04 Edition) § 1614.101 1614.402 Time for appeals to the Commis- sion. 1614.403 How to appeal. 1614.404 Appellate procedure. 1614.405 Decisions on appeals. 1614.406 Time limits. [Reserved] 1614.407 Civil action: Title VII, Age Dis- crimination in Employment Act and Re- habilitation Act. 1614.408 Civil action: Equal Pay Act. 1614.409 Effect of filing a civil action. Subpart E-Remedies and Enforcement 1614.501 Remedies and relief. 1614.502 Compliance with final Commission

  7. Document

    National Nuclear Security Administration (NNSA)

    66 29 CFR Ch. XIV (7-1-04 Edition) § 1614.101 1614.402 Time for appeals to the Commis- sion. 1614.403 How to appeal. 1614.404 Appellate procedure. 1614.405 Decisions on appeals. 1614.406 Time limits. [Reserved] 1614.407 Civil action: Title VII, Age Dis- crimination in Employment Act and Re- habilitation Act. 1614.408 Civil action: Equal Pay Act. 1614.409 Effect of filing a civil action. Subpart E-Remedies and Enforcement 1614.501 Remedies and relief. 1614.502 Compliance with final Commission

  8. Fusion Science to Prepare

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DIII-D Explorations of Fusion Science to Prepare for ITER and FNSF Dr. Richard Buttery General Atomics Tuesday, Dec 10, 2013 - 11:00AM MBG AUDITORIUM Refreshments at 10:45AM The PrinceTon Plasma Physics laboraTory is a U.s. DeParTmenT of energy faciliTy Recent DIII-D research has provided significant new in- formation for the physics basis of key scientific issues for successful operation of ITER and future steady state fu- sion tokamaks, including control of edge localized modes (ELMs), plasma

  9. S A V A N N A H R I V E R S I T E

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Excerpts from "Strengthening Energy Security through Federal Partnerships" 67 ENE RGY The Military Engineer * No. 676 The need to shrink depen dence on fos- sil fuels is not a new conce pt in the na- tion's energy discus sion, nor is the need to invest in clean, renew able energy . But the challe nge of how to deliver solar, bioma ss, wind, wave, geothe rmal and other power genera tion techno logies in a cost effecti ve, large-s cale mann er-an d meet the chang - ing energy deman ds of

  10. OSTIblog Articles in the Thomas Bayes Topic | OSTI, US Dept of Energy

    Office of Scientific and Technical Information (OSTI)

    Office of Scientific and Technical Information Bayes Topic The Reverend Thomas Bayes by Kathy Chambers 06 Nov, 2013 in Products and Content 13432 bayesPicture.jpg The Reverend Thomas Bayes Read more about 13432 During the 1700's, the Reverend Thomas Bayes was a nonconformist minister at the Mount Sion Chapel in Tunbridge Wells, UK, about 40 miles southeast of central London. Having studied both theology and logic at the University of Edinburgh, he was also a mathematician and developed a

  11. OSTI, US Dept of Energy Office of Scientific and Technical Information |

    Office of Scientific and Technical Information (OSTI)

    Speeding access to science information from DOE and Beyond The Reverend Thomas Bayes by Kathy Chambers on Wed, November 06, 2013 13432 bayesPicture.jpg The Reverend Thomas Bayes Read more about 13432 During the 1700's, the Reverend Thomas Bayes was a nonconformist minister at the Mount Sion Chapel in Tunbridge Wells, UK, about 40 miles southeast of central London. Having studied both theology and logic at the University of Edinburgh, he was also a mathematician and developed a strong

  12. untitled

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UNIVERSITY OF CALIFORNIA ileRL 919 cy 2 TWO-WEEK LOAN COpy This is a Library Circulating Copy which may be borrowed for two weeks. For a personal retention copy, call Tech. Info. Diu/sion, Ext. 5545 BERKELEY, CALIFORNIA '~ .:. .. -\ * UCRL-9l9 Unclassified Distribution UNIVERSITY OF CALIFORNIA Radiation Laboratory Contract No. W-7405-eng-48 A Thick Target for Synchrotrons and Betatrons E. M. McMillan September 19, 1950 Berkeley, California Unclassified Distribution ~2- USAF, USAF, USAF, USAF s

  13. L I NATIONAL' LEAD COMPANY OF OHIO

    Office of Legacy Management (LM)

    L I NATIONAL' LEAD COMPANY OF OHIO tJw HEALTH AND SAFETY DI"ISION - ANALITICIL DEPT. ANALYTICAL DATA SHEET _I . . NATIONAL LEAD COMPANY O F OHIO HEALTH AND SAFETY DIY1SION - ANALYTICAL DEPT. ANALYTICAL DATA SHEET NATIONA-i LEn' D COMPANY OF OHIO HEALTH AND SAFETY Dl"lSlDN - m4ALITICAL DEPT. ANALYTICAL DATA SHEET NO. I DlSTRlBUTlON OF COPIES I I A,w,lytlc.al Loboratorr (RBCORD COPI) 2 Induswlol Hvalen. B Rodhtlon Dept. 3 1 Water Trsotmmt Plant c=.z w&w hnp,., Only, - . _. NATIONAL

  14. Quality Assurance for Critical Decision Reviews RM

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Quality Assurance for Critical Decision Reviews Module March 2010 CD-0 O 0 OFFICE OF Q C CD-1 F ENVIRO Standard R Quality A Rev Critical Decis CD-2 M ONMENTAL Review Plan Assuranc view Module sion (CD) Ap CD March 2010 L MANAGE n (SRP) e (QA) e pplicability D-3 EMENT CD-4 Post Ope eration Standard Review Plan, 2 nd Edition, March 2010 i FOREWORD The Standard Review Plan (SRP) 1 provides a consistent, predictable corporate review framework to ensure that issues and risks that could challenge the

  15. Modular power converter having fluid cooled support

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Meyer, Andreas A.; Gollhardt, Neil; Kannenberg, Daniel G.

    2005-12-06

    A support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support, in conjunction with other packaging features may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  16. Electrical power converter method and system employing multiple output converters

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Meyer, Andreas A.; Gollhardt, Neil; Kannenberg, Daniel G.

    2007-05-01

    A support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support, in conjunction with other packaging features may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  17. Electrical power converter method and system employing multiple-output converters

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Meyer, Andreas A.; Gollhardt, Neil; Kannenberg, Daniel G.

    2006-03-21

    A support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support, in conjunction with other packaging features may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  18. Modular power converter having fluid cooled support

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Meyer, Andreas A.; Gollhardt, Neil; Kannenberg, Daniel G.

    2005-09-06

    A support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support, in conjunction with other packaging features may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  19. Compact fluid cooled power converter supporting multiple circuit boards

    DOE Patents [OSTI]

    Radosevich, Lawrence D.; Meyer, Andreas A.; Beihoff, Bruce C.; Kannenberg, Daniel G.

    2005-03-08

    A support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support, in conjunction with other packaging features may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  20. Radar imagery from the 1994 Lock Linnhe ship wake experiment

    SciTech Connect (OSTI)

    Mullenhoff, C.J.; Lehman, S.K.; Jones, H.

    1994-11-15

    The 1994 Loch Linnhe radar ocean imaging trials were held from September 4 through September 17. Two ships were used: the R.V. Colonel Templer, and the RMAS Collie. Thorn EMI, Inc., fielded a dual band, dual polarization radar on a hillside overlooking the loch. A primary purpose of the experiment was to obtain highly visible images of ship generated internal waves. Presented here is imagery for a few of the good ship runs, as well as a study of the environment of the visibility of ship generated internal waves.

  1. Natural Gas Basics (Brochure), U.S. Department of Energy (DOE), Energy Efficiency & Renewable Energy (EERE)

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Gas Basics Natural gas powers about 150,000 vehicles in the United States and roughly 22 million vehicles worldwide. 1 Natural gas vehicles (NGVs) are a good choice for high-mileage fleets- such as buses, taxis, and refuse vehicles-that are centrally fueled or operate within a lim- ited area or along a route with natural gas fueling stations. The advantages of natural gas as an alternative fuel include its domestic availability, estab- lished distribution network, relatively low cost, and emis-

  2. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making

    DOE Patents [OSTI]

    Gakh, Andrei A.; Vovk, Mykhaylo V.; Mel'nychenko, Nina V.; Sukach, Volodymyr A.

    2012-08-14

    The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds. EMI-C00001" he="48.09mm" wi="59.94mm" file="US08242284-20120814-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/>

  3. Lithium-Sulfur Batteries: Development of High Energy Lithium-Sulfur Cells for Electric Vehicle Applications

    SciTech Connect (OSTI)

    2010-10-01

    BEEST Project: Sion Power is developing a lithium-sulfur (Li-S) battery, a potentially cost-effective alternative to the Li-Ion battery that could store 400% more energy per pound. All batteries have 3 key partsa positive and negative electrode and an electrolytethat exchange ions to store and release electricity. Using different materials for these components changes a batterys chemistry and its ability to power a vehicle. Traditional Li-S batteries experience adverse reactions between the electrolyte and lithium-based negative electrode that ultimately limit the battery to less than 50 charge cycles. Sion Power will sandwich the lithium- and sulfur-based electrode films around a separator that protects the negative electrode and increases the number of charges the battery can complete in its lifetime. The design could eventually allow for a battery with 400% greater storage capacity per pound than Li-Ion batteries and the ability to complete more than 500 recharge cycles.

  4. Commissioning Measurements and Experience Obtained from the Installation of a Fissile Mass Flow monitor in the URAL Electrochemical Integrated Plant (UEIP) in Novouralsk

    SciTech Connect (OSTI)

    March-Leuba, J.; Mastal, E.; Powell, D.; Sumner, J.; Uckan, T.; Vines, V.

    1999-07-25

    The Blend Down Monitoring System (BDMS) equipment sent earlier to the Ural Electrochemical Integrated Plant (UEIP) at Novouralsk, Russia, was installed and implemented successfully on February 2, 1999. The BDMS installation supports the highly enriched uranium (HEU) Transparency Implementation Program for material subject to monitoring under the HEU purchase agreement between the United States of America (USA) and the Russian Federation (RF). The BDMS consists of the Oak Ridge National Laboratory (ORNL) Fissile (uranium-235) Mass Flow Monitor (FMFM) and the Los Alamos National Laboratory (LANL) Enrichment Monitor (EM). Two BDMS?s for monitoring the Main and Reserve HEU blending process lines were installed at UEIP. Independent operation of the FMFM Main and FMFM Reserve was successfully demonstrated for monitoring the fissile mass flow as well as the traceability of HEU to the product low enriched uranium. The FMFM systems failed when both systems were activated during the calibration phase due to a synchronization problem between the systems. This operational failure was caused by the presence of strong electromagnetic interference (EMI) in the blend point. The source-modulator shutter motion of the two FMFM systems was not being properly synchronized because of EMI producing a spurious signal on the synchronization cable connecting the two FMFM cabinets. The signature of this failure was successfully reproduced at ORNL after the visit. This unexpected problem was eliminated by a hardware modification and software improvements during a recent visit (June 9-11, 1999) to UEIP, and both systems are now operating as expected.

  5. Constant-current charging supplies for the Advanced Photon Source (APS) linear accelerator modulators

    SciTech Connect (OSTI)

    Fuja, R.; Grelick, A.E.; Meyer, D.

    1997-06-01

    The APS linac beam energy must be stable to within {+-}1% to match the energy acceptance of the positron accumulator ring. The klystron pulse modulators must therefore provide a pulse-to-pulse repeatability of 0.1% in order for the beam to have the required energy stability. The modulators have had difficulty achieving the necessary repeatability since the pulse forming network (PFN) charging scheme does not include a deQing circuit. Several of the major charging circuit components are also less reliable than desired. In order to increase operating reliability and to improve pulse-to-pulse stability, it is planned to replace the high voltage power supplies in all modulators with constant-current power supplies. A new modulator charging supply that contains two EMI series 303 constant-current power supplies was constructed. Each of these EMI supplies delivers 1.5 A at up to 40 kV. One supply is sufficient for linac operation at up to 45 Hz, and two supplies in parallel enable linac operation at the nominal rf repetition rate of 60 Hz. This paper discusses test results from the new modulator, and also describes the existing modulators and their performance limitations.

  6. Renewable Energy, Photovoltaic Systems Near Airfields. Electromagnetic Interference

    SciTech Connect (OSTI)

    Deline, Chris; Dann, Geoff

    2015-04-01

    Recent increases in photovoltaic (PV) systems on Department of the Navy (DON) land and potential siting near airfields prompted Commander, Naval Installations Command to fund the Naval Facilities Engineering Command to evaluate the impact of electromagnetic interference (EMI) from PV systems on airfield electronic equipment. Naval Facilities Engineering and Expeditionary Warfare Center tasked Department of Energy National Renewable Energy laboratory (NREL) to conduct the assessment. PV systems often include high-speed switching semiconductor circuits to convert the voltage produced by the PV arrays to the voltage needed by the end user. Switching circuits inherently produce electromagnetic radiation at harmonics of the switching frequency. In this report, existing literature is summarized and tests to measure emissions and mitigation methods are discussed. The literature shows that the emissions from typical PV systems are low strength and unlikely to cause interference to most airfield electronic systems. With diligent procurement and siting of PV systems, including specifications for FCC Part 15 Class A compliant equipment and a 250-foot setback from communication equipment, NREL anticipates little to no EMI impact on nearby communications or telemetry equipment.

  7. Donald Frederick, LLNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Donald Frederick, LLNL - Presented at Supercomputing 11 Lawrence Livermore National Laboratory, P. O. Box 808, Livermore, CA 94551! Case Study: Beyond Homogeneous Decomposition with Qbox Scaling Long-Range Forces on Massively Parallel Systems LLNL---PRES---508651 Case S tudy: O utline * Problem D escripBon * ComputaBonal A pproach * Changes f or S caling LLNL---PRES---508651 Computer s imulaBons o f m aterials Computer s imulaBons a re w idely used t o p redict t he p roperBes o f new m aterials

  8. Douglas Jacobsen! NERSC User Services Group

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Services Group Using Modules at NERSC --- 1 --- September 10, 2013 NERSC Supported Software * NERSC p rovides a w ide r ange o f s cien=fic a nd c omputer programming s o@ware t o u sers - Scien)fic A pplica)ons: V ASP, A mber, N AMD, ABySS, ... - Compilers: p gi, i ntel, g cc, c ray - Scrip)ng L anguages: perl, p ython, R * and p ackages f or e ach! - SoIware L ibraries: b las/lapack ( MKL), b oost, h df5, n etcdf, ... - U)li)es: gnuplot, g it, m ercurial, 7 zip, c make, . .. - Debuggers &

  9. Communication: X-ray coherent diffractive imaging by immersion in nanodroplets

    SciTech Connect (OSTI)

    Tanyag, Rico Mayro P.; Bernando, Charles; Jones, Curtis F.; Bacellar, Camila; Ferguson, Ken R.; Anielski, Denis; Boll, Rebecca; Carron, Sebastian; Cryan, James P.; Englert, Lars; Epp, Sascha W.; Erk, Benjamin; Foucar, Lutz; Gomez, Luis F.; Hartmann, Robert; Neumark, Daniel M.; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Siefermann, Katrin R.; Ullrich, Joachim; Weise, Fabian; Bostedt, Christoph; Gessner, Oliver; Vilesov, Andrey F.

    2015-10-14

    Lensless x-ray microscopy requires the recovery of the phase of the radiation scattered from a specimen. Here, we demonstrate a <i>de novo phase retrieval technique by encapsulating an object in a superfluid helium nanodroplet, which provides both a physical support and an approximate scattering phase for the iterative image reconstruction. The technique is robust, fast-converging, and yields the complex density of the immersed object. As a result, images of xenon clusters embedded in superfluid helium droplets reveal transient configurations of quantum vortices in this fragile system.

  10. Search for liquids electrospraying the smallest possible nanodrops in vacuo

    SciTech Connect (OSTI)

    Alonso-Matilla, R.; Fernndez-Garca, J.; Congdon, H.; Fernndez de la Mora, J.

    2014-12-14

    Prior work with electrosprays in vacuum of mixtures of ionic liquids (ILs) and the moderately high boiling point (T{sub b}) solvents formamide (FM) and propylene carbonate (PC) (T{sub b} of 210 and 241?C) has shown that the charged drops produced have reasonably narrow charge/mass distributions, controllable over a wide mass/charge range. This enables their use as propellants in electrical propulsion with specific impulse I{sub sp} varying from a few hundred to a few thousand seconds (10?kV beam energy) and with excellent propulsion efficiency. However, some limitations are imposed by the finite room temperature volatility of FM and PC. Here, we seek improved performance from propellants based on the polar but viscous solvent Sulfolane (SF; ??=?43.2, ??=?10.3 cP) and the low viscosity but less polar solvent tributyl phosphate (TBP; ??=?8.9, ??=?3.4 cP), both with T{sub b}?>?280?C. Neither TBP nor its low viscosity mixtures with SF achieve the electrical conductivities needed to yield high I{sub sp}. Most ILs used in SF/IL mixtures tested were based on the 1-ethyl-3-methylimidazolium (EMI) or 1,3-dimethylimidazolium (DMI) cations, including EMI-BF{sub 4}, EMI-N(CN){sub 2}, and DMI-N(CN){sub 2}. These combinations reach high conductivities, some approaching 3?S/m, but have limited propulsive performance because evaporation of ions directly from the electrified meniscus produces undesirable mixed beams of drops and ions. Exceptional characteristics are found in mixtures of SF with ethylammonium nitrate (EAN), where the small EA{sup +} cation is strongly bound to the solvent, greatly delaying ion evaporation from the meniscus. Evidence on the formation of nano-jets with diameters as small as 1?nm is seen. Although unprecedented, this finding agrees with what would be expected if ion evaporation were suppressed. SF/EAN mixtures thus provide the best available sources to produce the smallest possible nanodrops, minimally polluted by ions.

  11. Sandwiched Rnyi divergence satisfies data processing inequality

    SciTech Connect (OSTI)

    Beigi, Salman [School of Mathematics, Institute for Research in Fundamental Sciences (IPM), P.O. Box 19395-5746, Tehran (Iran, Islamic Republic of)] [School of Mathematics, Institute for Research in Fundamental Sciences (IPM), P.O. Box 19395-5746, Tehran (Iran, Islamic Republic of)

    2013-12-15

    Sandwiched (quantum) ?-Rnyi divergence has been recently defined in the independent works of Wilde et al. [Strong converse for the classical capacity of entanglement-breaking channels, preprint http://arxiv.org/abs/arXiv:1306.1586 (2013)] and Mller-Lennert et al. [On quantum Rnyi entropies: a new definition, some properties and several conjectures, preprint http://arxiv.org/abs/arXiv:1306.3142v1 (2013)]. This new quantum divergence has already found applications in quantum information theory. Here we further investigate properties of this new quantum divergence. In particular, we show that sandwiched ?-Rnyi divergence satisfies the data processing inequality for all values of ? > 1. Moreover we prove that ?-Holevo information, a variant of Holevo information defined in terms of sandwiched ?-Rnyi divergence, is super-additive. Our results are based on Hlder's inequality, the Riesz-Thorin theorem and ideas from the theory of complex interpolation. We also employ Sion's minimax theorem.

  12. Utilizing Semantic Big Data for realizing a National-scale Infrastructure Vulnerability Analysis System

    SciTech Connect (OSTI)

    Chinthavali, Supriya; Shankar, Mallikarjun

    2016-01-01

    Critical Infrastructure systems(CIs) such as energy, water, transportation and communication are highly interconnected and mutually dependent in complex ways. Robust modeling of CIs interconnections is crucial to identify vulnerabilities in the CIs. We present here a national-scale Infrastructure Vulnerability Analysis System (IVAS) vision leveraging Se- mantic Big Data (SBD) tools, Big Data, and Geographical Information Systems (GIS) tools. We survey existing ap- proaches on vulnerability analysis of critical infrastructures and discuss relevant systems and tools aligned with our vi- sion. Next, we present a generic system architecture and discuss challenges including: (1) Constructing and manag- ing a CI network-of-networks graph, (2) Performing analytic operations at scale, and (3) Interactive visualization of ana- lytic output to generate meaningful insights. We argue that this architecture acts as a baseline to realize a national-scale network based vulnerability analysis system.

  13. FIlea

    Office of Legacy Management (LM)

    FIlea THRU: R. L. Kirk and 3. N. ?%l.mxe Hr. Brandgun of Health CC Safety ?M.sion and the wrfte~! tisited -de onJamwy 8,19% to lnvastl@ethe aause of tbs fire In aSJlvenio sarap nhipmnttoHWat St. Lauis. The per&x13 ccmtactod vere I-I. Grleb, W. J. Danahue, and A. A. cannon of Sylv@a. On DeoemSar 23, 1953, Sylvnnla, S-de, supped 809 &i. of uranium acrap,wtich vas identlfled on SF 1Ol Fona 110. 4 - SYL tg MX 83 urcminmbar and&de scrap. I On Saturday, hxnh~r 26, 1953, MIX vaa notified tv

  14. Vadose Zone Transport Field Study: Status Report

    SciTech Connect (OSTI)

    Gee, Glendon W.; Ward, Anderson L.

    2001-11-30

    Studies were initiated at the Hanford Site to evaluate the process controlling the transport of fluids in the vadose zone and to develop a reliable database upon which vadose-zone transport models can be calibrated. These models are needed to evaluate contaminant migration through the vadose zone to underlying groundwaters at Hanford. A study site that had previously been extensively characterized using geophysical monitoring techniques was selected in the 200 E Area. Techniques used previously included neutron probe for water content, spectral gamma logging for radionuclide tracers, and gamma scattering for wet bulk density. Building on the characterization efforts of the past 20 years, the site was instrumented to facilitate the comparison of nine vadose-zone characterization methods: advanced tensiometers, neutron probe, electrical resistance tomography (ERT), high-resolution resistivity (HRR), electromagnetic induction imaging (EMI), cross-borehole radar (XBR), and cross-borehole seismic (XBS). Soil coring was used to obtain soil samples for analyzing ionic and isotopic tracers.

  15. Compact vehicle drive module having improved thermal control

    DOE Patents [OSTI]

    Meyer, Andreas A.; Radosevich, Lawrence D.; Beihoff, Bruce C.; Kehl, Dennis L.; Kannenberg, Daniel G.

    2006-01-03

    An electric vehicle drive includes a thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support, which may be controlled in a closed-loop manner. Interfacing between circuits, circuit mounting structure, and the support provide for greatly enhanced cooling. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  16. Power converter having improved fluid cooling

    DOE Patents [OSTI]

    Meyer, Andreas A.; Radosevich, Lawrence D.; Beihoff, Bruce C.; Kehl, Dennis L.; Kannenberg, Daniel G.

    2007-03-06

    A thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support, which may be controlled in a closed-loop manner. Interfacing between circuits, circuit mounting structure, and the support provide for greatly enhanced cooling. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  17. Vehicle drive module having improved cooling configuration

    DOE Patents [OSTI]

    Radosevich, Lawrence D.; Meyer, Andreas A.; Kannenberg, Daniel G.; Kaishian, Steven C.; Beihoff, Bruce C.

    2007-02-13

    An electric vehicle drive includes a thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. Power electronic circuits are thermally matched, such as between component layers and between the circuits and the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  18. Prefire identification for pulse-power systems

    DOE Patents [OSTI]

    Longmire, J.L.; Thuot, M.E.; Warren, D.S.

    1982-08-23

    Prefires in a high-power, high-frequency, multi-stage pulse generator are detected by a system having an EMI shielded pulse timing transmitter associated with and tailored to each stage of the pulse generator. Each pulse timing transmitter upon detection of a pulse triggers a laser diode to send an optical signal through a high frequency fiber optic cable to a pulse timing receiver which converts the optical signal to an electrical pulse. The electrical pulses from all pulse timing receivers are fed through an OR circuit to start a time interval measuring device and each electrical pulse is used to stop an individual channel in the measuring device thereby recording the firing sequence of the multi-stage pulse generator.

  19. Prefire identification for pulse power systems

    DOE Patents [OSTI]

    Longmire, Jerry L.; Thuot, Michael E.; Warren, David S.

    1985-01-01

    Prefires in a high-power, high-frequency, multi-stage pulse generator are detected by a system having an EMI shielded pulse timing transmitter associated with and tailored to each stage of the pulse generator. Each pulse timing transmitter upon detection of a pulse triggers a laser diode to send an optical signal through a high frequency fiber optic cable to a pulse timing receiver which converts the optical signal to an electrical pulse. The electrical pulses from all pulse timing receivers are fed through an OR circuit to start a time interval measuring device and each electrical pulse is used to stop an individual channel in the measuring device thereby recording the firing sequence of the multi-stage pulse generator.

  20. Cooled electrical terminal assembly and device incorporating same

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Phillips, Mark G.; Kehl, Dennis L.; Kaishian, Steven C.; Kannenberg, Daniel G.

    2005-05-24

    A terminal structure provides interfacing with power electronics circuitry and external circuitry. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the terminal structure and the circuits through fluid circulating through the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  1. Cooled electrical terminal assembly and device incorporating same

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Phillips, Mark G.; Kehl, Dennis L.; Kaishian, Steven C.; Kannenberg, Daniel G.

    2006-08-22

    A terminal structure provides interfacing with power electronics circuitry and external circuitry. The thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the terminal structure and the circuits through fluid circulating through the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  2. Thermally matched fluid cooled power converter

    DOE Patents [OSTI]

    Radosevich, Lawrence D.; Kannenberg, Daniel G.; Kaishian, Steven C.; Beihoff, Bruce C.

    2005-06-21

    A thermal support may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. Power electronic circuits are thermally matched, such as between component layers and between the circuits and the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as improved terminal configurations. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  3. Nano-scaled graphene platelets with a high length-to-width aspect ratio

    DOE Patents [OSTI]

    Zhamu, Aruna; Guo, Jiusheng; Jang, Bor Z.

    2010-09-07

    This invention provides a nano-scaled graphene platelet (NGP) having a thickness no greater than 100 nm and a length-to-width ratio no less than 3 (preferably greater than 10). The NGP with a high length-to-width ratio can be prepared by using a method comprising (a) intercalating a carbon fiber or graphite fiber with an intercalate to form an intercalated fiber; (b) exfoliating the intercalated fiber to obtain an exfoliated fiber comprising graphene sheets or flakes; and (c) separating the graphene sheets or flakes to obtain nano-scaled graphene platelets. The invention also provides a nanocomposite material comprising an NGP with a high length-to-width ratio. Such a nanocomposite can become electrically conductive with a small weight fraction of NGPs. Conductive composites are particularly useful for shielding of sensitive electronic equipment against electromagnetic interference (EMI) or radio frequency interference (RFI), and for electrostatic charge dissipation.

  4. Electromagnetic Isolation Solutions in Low Temperature Cofired Ceramic (LTCC)

    SciTech Connect (OSTI)

    Krueger, Daniel; Peterson, Ken; Euler, Laurie

    2011-10-09

    Low Temperature Cofired Ceramic (LTCC) is a commercial ceramic-glass multilayer technology with compelling advantages for microelectronics, microsystems and sensors. High frequency applications require good electrical properties such as low dielectric loss and newer applications require extreme isolation from electromagnetic interference (EMI) that is even difficult to measure (-150db). Approaches to providing this isolation, once provided by via fences, have included sidewall coating and full tape thickness features (FTTF) that have been introduced by the filling of slots with via-fill compositions. Several techniques for creating these structures have been modeled for stress and temperature effects in the face of other necessary attachments, such as metallic seal frames. The relative effects of attachment media, FTTF geometry, and alternative measures will be reported. Approaches for thick film and thin film implementations are described.

  5. High rate capacitive performance of single-walled carbon nanotube aerogels

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Van Aken, Katherine L.; Pérez, Carlos R.; Oh, Youngseok; Beidaghi, Majid; Joo Jeong, Yeon; Islam, Mohammad F.; Gogotsi, Yury

    2015-05-30

    Single-walled carbon nanotube (SWCNT) aerogels produced by critical-point-drying of wet-gel precursors exhibit unique properties, such as high surface-area-to-volume and strength-to-weight ratios. They are free-standing, are binder-free, and can be scaled to thicknesses of more than 1 mm. In this paper, we examine the electric double layer capacitive behavior of these materials using a common room temperature ionic liquid electrolyte, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI-TFSI). Electrochemical performance is assessed through galvanostatic cycling, cyclic voltammetry and impedance spectroscopy. Results indicate stable capacitive performance over 10,000 cycles as well as an impressive performance at high charge and discharge rates, due to accessible pore networks andmore » enhanced electronic and ionic conductivities of SWCNT aerogels. Finally, these materials can find applications in mechanically compressible and flexible supercapacitor devices with high power requirements.« less

  6. Subsea fiber-optic communications

    SciTech Connect (OSTI)

    High, G.; Wright, P.J.

    1997-05-01

    High-cost and hazardous nature of recovering hydrocarbons offshore have led to the trend towards growth in subsea production control. The extended step-out distances of subsea completions is increasing the volume and complexity of subsea data communications beyond the capacity of conventional systems. Improved reservoir management using intelligent sensors, metering, and process equipment, requiring real-time monitoring and control, dictates the use of wideband communication. Fiber optics offers the necessary volume of data transmission, with the high-noise immunity needed for data integrity and safe operation, under the severe Electro-Magnetic Interference (EMI) environments created where high power motors and power cables are used subsea. The marinizing of optical, opto-electronic communication components for production control, data acquisition of subsea completions for the offshore oil industry are described.

  7. Vehicle drive module having improved terminal design

    DOE Patents [OSTI]

    Beihoff, Bruce C.; Radosevich, Lawrence D.; Phillips, Mark G.; Kehl, Dennis L.; Kaishian, Steven C.; Kannenberg, Daniel G.

    2006-04-25

    A terminal structure for vehicle drive power electronics circuits reduces the need for a DC bus and thereby the incidence of parasitic inductance. The structure is secured to a support that may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as by direct contact between the terminal assembly and AC and DC circuit components. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  8. Power converter having improved terminal structure

    DOE Patents [OSTI]

    Radosevich, Lawrence D.; Kannenberg, Daniel G.; Phillips, Mark G.; Kaishian, Steven C.

    2007-03-06

    A terminal structure for power electronics circuits reduces the need for a DC bus and thereby the incidence of parasitic inductance. The structure is secured to a support that may receive one or more power electronic circuits. The support may aid in removing heat from the circuits through fluid circulating through the support. The support may form a shield from both external EMI/RFI and from interference generated by operation of the power electronic circuits. Features may be provided to permit and enhance connection of the circuitry to external circuitry, such as by direct contact between the terminal assembly and AC and DC circuit components. Modular units may be assembled that may be coupled to electronic circuitry via plug-in arrangements or through interface with a backplane or similar mounting and interconnecting structures.

  9. The propagation characteristics of electromagnetic waves through plasma in the near-field region of low-frequency loop antenna

    SciTech Connect (OSTI)

    Liu, DongLin Li, XiaoPing; Xie, Kai; Liu, ZhiWei

    2015-10-15

    A high-speed vehicle flying through the atmosphere between 100 and 20 km may suffer from a “communication blackout.” In this paper, a low frequency system with an on-board loop antenna to receive signals is presented as a potential blackout mitigation method. Because the plasma sheath is in the near-field region of the loop antenna, the traditional scattering matrix method that is developed for the far-field region may overestimate the electromagnetic (EM) wave's attenuation. To estimate the EM wave's attenuation in the near-field region, EM interference (EMI) shielding theory is introduced. Experiments are conducted, and the results verify the EMI shielding theory's effectiveness. Simulations are also conducted with different plasma parameters, and the results obtained show that the EM wave's attenuation in the near-field region is far below than that in the far-field region. The EM wave's attenuation increases with the increase in electron density and decreases with the increase in collision frequency. The higher the frequency, the larger is the EM wave's attenuation. During the entire re-entry phase of a RAM-C module, the EM wave's attenuations are below 10 dB for EM waves with a frequency of 1 MHz and below 1 dB for EM waves with a frequency of 100 kHz. Therefore, the low frequency systems (e.g., Loran-C) may provide a way to transmit some key information to high-speed vehicles even during the communication “blackout” period.

  10. An electromagnetic induction method for underground target detection and characterization

    SciTech Connect (OSTI)

    Bartel, L.C.; Cress, D.H.

    1997-01-01

    An improved capability for subsurface structure detection is needed to support military and nonproliferation requirements for inspection and for surveillance of activities of threatening nations. As part of the DOE/NN-20 program to apply geophysical methods to detect and characterize underground facilities, Sandia National Laboratories (SNL) initiated an electromagnetic induction (EMI) project to evaluate low frequency electromagnetic (EM) techniques for subsurface structure detection. Low frequency, in this case, extended from kilohertz to hundreds of kilohertz. An EMI survey procedure had already been developed for borehole imaging of coal seams and had successfully been applied in a surface mode to detect a drug smuggling tunnel. The SNL project has focused on building upon the success of that procedure and applying it to surface and low altitude airborne platforms. Part of SNL`s work has focused on improving that technology through improved hardware and data processing. The improved hardware development has been performed utilizing Laboratory Directed Research and Development (LDRD) funding. In addition, SNL`s effort focused on: (1) improvements in modeling of the basic geophysics of the illuminating electromagnetic field and its coupling to the underground target (partially funded using LDRD funds) and (2) development of techniques for phase-based and multi-frequency processing and spatial processing to support subsurface target detection and characterization. The products of this project are: (1) an evaluation of an improved EM gradiometer, (2) an improved gradiometer concept for possible future development, (3) an improved modeling capability, (4) demonstration of an EM wave migration method for target recognition, and a demonstration that the technology is capable of detecting targets to depths exceeding 25 meters.

  11. Short time proton dynamics in bulk ice and in porous anode solid oxide fuel cell materials

    SciTech Connect (OSTI)

    Basoli, Francesco; Senesi, Roberto; Kolesnikov, Alexander I; Licoccia, Silvia

    2014-01-01

    Oxygen reduction and incorporation into solid electrolytes and the reverse reaction of oxygen evolution play a cru-cial role in Solid Oxide Fuel Cell (SOFC) applications. However a detailed un derstanding of the kinetics of the cor-responding reactions, i.e. on reaction mechanisms, rate limiting steps, reaction paths, electrocatalytic role of materials, is still missing. These include a thorough characterization of the binding potentials experienced by protons in the lattice. We report results of Inelastic Neutron Scattering (INS) measurements of the vibrational state of the protons in Ni- YSZ highly porous composites (75% to 90% ), a ceramic-metal material showing a high electrical conductivity and ther mal stability, which is known to be most effectively used as anodes for solid ox ide fuel cells. The results are compared with INS and Deep Inelastic Neutron Scattering (DINS) experiments on the proton binding states in bulk ice.

  12. NERSC Schedule.xlsx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    :00---9:30 Registration a nd l aptop s et---up 9:30---9:45 Introductions 9:45---10:45 Chapter 1 . W hy o bject---oriented p rogramming ( OOP)? 10:45---11:00 Break 11:00---11:30 Example: F ireworks s imulation v ia p rocedural p rogramming 11:30---12:00 Section 2 .1 N omenclature, S ection 2 .2 O bject---Oriented A nalysis a nd D esign 12:00---1:00 Lunch B reak 1:00---1:30 Section 2 .3 E ncapsulation a nd I nformation H iding , S ection 2 .4 W rapping L egacy S oftware 1:30---2:00 Section 2 .5 C

  13. Hyperspectral image reconstruction for x-ray fluorescence tomography

    SciTech Connect (OSTI)

    Grsoy, Do?a; Bier, Tekin; Lanzirotti, Antonio; Newville, Matthew G.; De Carlo, Francesco

    2015-01-01

    A penalized maximum-likelihood estimation is proposed to perform hyperspectral (spatio-spectral) image reconstruction for X-ray fluorescence tomography. The approach minimizes a Poisson-based negative log-likelihood of the observed photon counts, and uses a penalty term that has the effect of encouraging local continuity of model parameter estimates in both spatial and spectral dimensions simultaneously. The performance of the reconstruction method is demonstrated with experimental data acquired from a seed of arabidopsis thaliana collected at the 13-ID-E microprobe beamline at the Advanced Photon Source. The resulting element distribution estimates with the proposed approach show significantly better reconstruction quality than the conventional analytical inversion approaches, and allows for a high data compression factor which can reduce data acquisition times remarkably. In particular, this technique provides the capability to tomographically reconstruct full energy dispersive spectra without compromising reconstruction artifacts that impact the interpretation of results.

  14. WIPP Update 3_29_14

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9, 2 014 Seven a ctivities t o r ecovery a nd r e---entry NWP h as d eveloped a nd i mplemented a r ecovery p lan t hat i ncorporates s even a ctivities n ecessary t o keep the p ublic, e nvironment, a nd employees s afe, m itigate t he r adiation s ource, a nd r estore operations. T he s even a ctivities i nclude: * Activity 1 - I solate v entilation f low---through: T wo 1 0---foot w ide b ypass d ampers, t hat c ould a llow limited a irflow t o b ypass H EPA f ilters, w ere s ealed w ith h

  15. Hyperspectral image reconstruction for x-ray fluorescence tomography

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Grsoy, Do?a; Bier, Tekin; Lanzirotti, Antonio; Newville, Matthew G.; De Carlo, Francesco

    2015-01-01

    A penalized maximum-likelihood estimation is proposed to perform hyperspectral (spatio-spectral) image reconstruction for X-ray fluorescence tomography. The approach minimizes a Poisson-based negative log-likelihood of the observed photon counts, and uses a penalty term that has the effect of encouraging local continuity of model parameter estimates in both spatial and spectral dimensions simultaneously. The performance of the reconstruction method is demonstrated with experimental data acquired from a seed of arabidopsis thaliana collected at the 13-ID-E microprobe beamline at the Advanced Photon Source. The resulting element distribution estimates with the proposed approach show significantly better reconstruction quality than the conventional analytical inversionmoreapproaches, and allows for a high data compression factor which can reduce data acquisition times remarkably. In particular, this technique provides the capability to tomographically reconstruct full energy dispersive spectra without compromising reconstruction artifacts that impact the interpretation of results.less

  16. FY2011 Progress Report: Agreement 8697 - NOx Sensor Development

    SciTech Connect (OSTI)

    Woo, L Y; Glass, R S

    2011-11-01

    different concentration regimes obtained from bench-level laboratory evaluation were used to adjust the sensor signal in dynamometer testing. Both NO{sub x} and O{sub 2} exhibited non-linear responses over the concentration regimes examined (0-100 ppm for NO{sub x} and 4-7% for O{sub 2}). Adjusted sensor signals had better agreement with both a commercial NO{sub x} sensor and FTIR measurements. However, the lack of complete agreement indicated that it was not possible to completely account for the nonlinear sensor behavior in certain concentration regimes. The agreement at lower NO{sub x} levels (less than 20 ppm) was better than at higher levels (50-100 ppm). Other progress in FY2011 included dynamometer testing of sensors with imbedded heaters and protective housings that were mounted directly into the exhaust manifold. Advanced testing protocols were used to evaluate the sensors. These experiments confirmed the potential for sensor robustness and durability. Advanced material processing methods appropriate for mass manufacturing, such as sputtering, are also being evaluated. A major milestone for this past year was the licensing of the LLNL NO{sub x} sensor technology to EmiSense Technologies, LLC. EmiSense has extensive experience and resources for the development of emission control sensors. A CRADA is in development that will allow LLNL to work in partnership with EmiSense to bring the LLNL NO{sub x} sensor technology to commercialization. Ford Motor Company is also a partner in this effort.

  17. Elimination of GeO(2) And Ge(3)N(4) Interfacial Transition Regions And Defects at N-Type Ge Interfaces: a Pathway for Formation of N-MOS Devices on Ge Substrates

    SciTech Connect (OSTI)

    Lucovsky, G.; Lee, S.; Long, J.P.; Seo, H.; Luning, J.

    2009-05-19

    The contribution from relatively low-K SiON interfacial transition regions (ITRs) between Si and transition metal (TM) gate dielectrics places a significant limitation on equivalent oxide thickness (EOT) scaling for Si complementary metal-oxide-semiconductor (CMOS) devices. This limitation is equally significant and limiting for Ge CMOS devices. Low-K Ge-based ITRs in Ge devices have also been shown to limit performance and reliability, particular for n-MOS field effect transistors. This article identifies the source of significant electron trapping at interfaces between n-Ge or inverted p-Ge, and Ge oxide, nitride and oxynitride ITRs. This is shown to be an interfacial band alignment issue in which native Ge ITRs have conduction band offset energies smaller than those of TM dielectrics, and trap electrons for negative Ge substrate bias. This article also describes a novel remote plasma processing approach for effectively eliminating any significant native Ge ITRs and using a plasma-processing/annealing process sequence for bonding TM gate dielectrics directly to the Ge substrate surface.

  18. Porphyrin Based neuton capture agents for cancer therapy

    DOE Patents [OSTI]

    Vicente, Maria Da; Shetty, Shankar Jayaram; Jaquinod, Laurent; Smith, Kevin M.

    2006-06-27

    The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containing 5,10,15,20-tetraphenylporphyrins bearing 2544% boron by weight. In certain embodiments, a phenyl porphyrin compound has a carboranyl group attached to the phenyl group by a carbon-carbon linkage, wherein the phenyl group corresponds to the following formula EMI-C00001" he="24.21mm" wi="24.38mm" file="US07067653-20060627-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/>
    where R7 through R11 are hydrogen, a carboranyl group, or are selected from the group consisting of hydroxyl, NMe3+, PMePh2+, PO(OH)2, SO3H, COOH, and NH2. In this embodiment, the carboranyl group is attached to the phenyl group by a carbon-carbon linkage, either one or two of R7 through R11 are other than hydrogen; and the phenyl porphyrin compound contains at least one phenyl group having at least one of said carboranyl groups.

  19. Nonwoven fabrics made from nickel and stainless steel fibers

    SciTech Connect (OSTI)

    Stepro, J.A.

    1996-11-01

    Nonwoven fabrics made from metal fiber have uses in a variety of applications due to their alloy composition, heat resistivity, conductivity and durability. Applications include: filtration media, battery current collectors, EMI/RFI shielding, insulation and conductive fillers. The ability to form metal fibers into fabrics of non-directionalized fiber webs has led to improved materials in a variety of applications. The non-orientation of the fibers provides a three dimensional structure that is filled with materials such as nickel hydroxide, cadmium oxide and MH alloy used for battery applications or to act as a contaminate trap for filtration. Fibers made from nickel, stainless steel, iron, cobalt, monel and copper are all possibilities for use in nonwoven fabrics. The density, porosity and thickness are all controllable during the web formation process. Fiber diameter is also a critical consideration when specific pore sizes are targeted. Fiber diameters are controlled during the fiber formation process. Diameters as low as 6 microns in stainless steel and 9 microns in other alloys are possible.

  20. WARP: A modular wind power system for distributed electric utility application

    SciTech Connect (OSTI)

    Weisbrich, A.L.; Ostrow, S.L.; Padalino, J.P.

    1996-07-01

    Steady development of wind turbine technology, and the accumulation of wind farm operating experience, have resulted in the emergence of wind power as a potentially attractive source of electricity for utilities. Since wind turbines are inherently modular, with medium-sized units typically in the range of a few hundred kilowatts each, they lend themselves well to distributed generation service. A patented wind power technology, the Toroidal Accelerator Rotor Platform (TARP) Windframe, forms the basis for a proposed network-distributed, wind power plant combining electric generation and transmission. While heavily building on proven wind turbine technology, this system is projected to surpass traditional configuration windmills through a unique distribution/transmission combination, superior performance, user-friendly operation and maintenance, and high availability and reliability. Furthermore, its environmental benefits include little new land requirements, relatively attractive appearance, lower noise and EMI/TV interference, and reduced avian (bird) mortality potential. Its cost of energy is projected to be very competitive, in the range of from approximately 2{cents}/kWh to 5{cents}/kWh, depending on the wind resource.

  1. COE projection for the modular WARP{trademark} wind power system for wind farms and electric utility power transmission

    SciTech Connect (OSTI)

    Weisbrich, A.L.; Ostrow, S.L.; Padalino, J.

    1995-09-01

    Wind power has emerged as an attractive alternative source of electricity for utilities. Turbine operating experience from wind farms has provided corroborating data of wind power potential for electric utility application. Now, a patented modular wind power technology, the Toroidal Accelerator Rotor Platform (TARP{trademark}) Windframe{trademark}, forms the basis for next generation megawatt scale wind farm and/or distributed wind power plants. When arranged in tall vertically clustered TARP{trademark} module stacks, such power plant units are designated Wind Amplified Rotor Platform (WARP{trademark}) Systems. While heavily building on proven technology, these systems are projected to surpass current technology windmills in terms of performance, user-friendly operation and ease of maintenance. In its unique generation and transmission configuration, the WARP{trademark}-GT System combines both electricity generation through wind energy conversion and electric power transmission. Furthermore, environmental benefits include dramatically less land requirement, architectural appearance, lower noise and EMI/TV interference, and virtual elimination of bird mortality potential. Cost-of-energy (COE) is projected to be from under $0.02/kWh to less than $0.05/kWh in good to moderate wind resource sites.

  2. WARP{trademark}: A modular wind power system for distributed electric utility application

    SciTech Connect (OSTI)

    Weisbrich, A.L.; Ostrow, S.L.; Padalino, J.

    1995-12-31

    Steady development of wind turbine technology, and the accumulation of wind farm operating experience, have resulted in the emergence of wind power as a potentially attractive source of electricity for utilities. Since wind turbines are inherently modular, with medium-sized units typically in the range of a few hundred kW each, they lend themselves well to distributed generation service. A patented wind power technology, the Toroidal Accelerator Rotor Platform (TARP{trademark}) Windframe{trademark}, forms the basis for a proposed network-distributed, wind power plant combining electric generation and transmission. While heavily building on proven wind turbine technology, this system is projected to surpass traditional configuration windmills through a unique distribution/transmission combination, superior performance, user friendly operation and maintenance, and high availability and reliability. Furthermore, its environmental benefits include little new land requirements, relatively attractive appearance, lower noise and EMI/TV interference, and reduced avian (bird) mortality potential. Its cost of energy is projected to be very competitive, in the range of from approximately 2{cents}/kWh to 5{cents}/ kWh, depending on the wind resource.

  3. Porphyrin Based neuton capture agents for cancer therapy

    DOE Patents [OSTI]

    Vicente, Maria Da; Shetty, Shankar Jayaram; Jaquinod, Laurent; Smith, Kevin M.

    2006-06-27

    The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containing 5,10,15,20-tetraphenylporphyrins bearing 25–44% boron by weight. In certain embodiments, a phenyl porphyrin compound has a carboranyl group attached to the phenyl group by a carbon-carbon linkage, wherein the phenyl group corresponds to the following formula EMI-C00001" he="24.21mm" wi="24.38mm" file="US07067653-20060627-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/>
    where R7 through R11 are hydrogen, a carboranyl group, or are selected from the group consisting of hydroxyl, NMe3+, PMePh2+, PO(OH)2, SO3H, COOH, and NH2. In this embodiment, the carboranyl group is attached to the phenyl group by a carbon-carbon linkage, either one or two of R7 through R11 are other than hydrogen; and the phenyl porphyrin compound contains at least one phenyl group having at least one of said carboranyl groups.

  4. Task 2 - Limits for High-Frequency Conducted Susceptibility Testing - CS114 (NRC-HQ-60-14-D-0015)

    SciTech Connect (OSTI)

    Wood, Richard Thomas; Ewing, Paul D.; Moses, Rebecca J.

    2015-09-01

    A principal focus of Task 2 under this project was for ORNL to evaluate the basis for susceptibility testing against high-frequency conducted interference and to establish recommendations to resolve concerns about the severity of test limits for the conducted susceptibility (CS) test, CS114, from MIL-STD-461. The primary concern about the test limit has been characterized by the EPRI EMI Working Group in the following terms: Demonstrating compliance with the CS114 test limits recommended in TR-102323 has proven to be problematic, even for components that have been tested to commercial standards and demonstrated proper operation in industrial applications [6]. Specifically, EPRI notes that the CS114 limits approved in regulatory documents are significantly higher than those invoked by the US military and similar commercial standards in the frequency range below 200 kHz. For this task, ORNL evaluated the original approach to establishing the test limit, EPRI technical findings from a review of the limit, and the regulatory basis through which the currently approved limits were accepted. Based on this analysis, strategies have been developed regarding changes to the CS114 limit that can resolve the technical concerns raised by the industry. Guided by the principles that reasonable assurance of safety must not be compromised but excessive conservatism should be reduced, recommendations on a suitable basis for a revised limit have been developed and can be incorporated into the planned Revision 2 of RG 1.180.

  5. Application of water jet assisted drag bit and pick cutter for the cutting of coal measure rocks. Final technical report. [Tests of combination in different rocks

    SciTech Connect (OSTI)

    Ropchan, D.; Wang, F.D.; Wolgamott, J.

    1980-04-01

    A laboratory investigation was made of the effects of high pressure water jets on the cutting forces of drag bit cutters in sedimentary rocks. A hard and soft sandstone, shale and limestone were tested with commercially obtainable conical and plow type drag bits on the EMI linear cutting machine. About 1200 cuts were made at different bit penetration, jet orientation, and water pressure to determine the reduction of cutting forces on the bit from the use of the water jet. Both independent and interactive cutting was used. The greatest reduction in cutting forces were with both of the sandstones; the drag forces were reduced about 30 percent and the normal forces about 60 percent at 5000 psi water pressure with the nozzle behind the bit. The method was less effective in the shale, except at 10,000 psi water pressure the reduction in drag force was about 55 percent. Of the rocks tested, the limestone was least affected by the water jet. The cutting forces for the plow bit showed continuous change with wear so a machined conical bit was used for most of the testing. Tests with the plow bit did show a large reduction in cutting forces by using the water jet with worn bits. An economic analysis of equipping a drag bit tunnel boring machine indicated that the water jet system could reduce costs per foot in sandstone by up to 40 percent.

  6. High power connection system

    DOE Patents [OSTI]

    Schaefer, Christopher E.; Beer, Robert C.; McCall, Mark D.

    2000-01-01

    A high power connection system adapted for automotive environments which provides environmental and EMI shielding includes a female connector, a male connector, and a panel mount. The female connector includes a female connector base and a snap fitted female connector cover. The male connector includes a male connector base and a snap fitted male connector cover. The female connector base has at least one female power terminal cavity for seatably receiving a respective female power terminal. The male connector base has at least one male power terminal cavity for seatably receiving a respective male power terminal. The female connector is covered by a cover seal and a conductive shroud. A pair of lock arms protrude outward from the front end of the male connector base, pass through the panel mount and interface with a lever of a lever rotatably connected to the shroud to thereby mechanically assist mating of the male and female connectors. Safety terminals in the male and female connectors provide a last-to-connect-first-to-break connection with an HVIL circuit.

  7. Subsea fiber optic communications for production control and data acquisition

    SciTech Connect (OSTI)

    High, G.; Wright, P.J.

    1996-12-31

    The trend to reduce topside facilities and the frequent use of subsea completions over extended step-out distances has increased the volume and complexity of subsea data communications beyond the capacity of conventional systems. Improved reservoir management using intelligent sensors, metering and process equipment, requiring real-time monitoring and control, dictates the use of wideband communication. Fiber optics offers the necessary volume of data transmission, with the high noise immunity needed for data integrity and safety, for the severe EMI environments created where motors and power cables are used. The system uses conventional optical fiber conductors with 1,550 nm laser generated optical pulses as the information carrier. Data rates of 2.0 Mb/s are achievable, unrepeated, over distances in excess of 100 Km, with extremely low error rates,. Equipment and installation costs will be comparable with current hard-wired technology, demonstrating that single mode optical communication is a technically and commercially feasible, and reliable, alternative to existing electrical systems.

  8. Application and testing of a fiber optic communication system at Grand Coulee

    SciTech Connect (OSTI)

    Osburn, G.D.; Arnold, R.G.

    1988-03-01

    The U.S. Bureau of Reclamation (USBR) operates the world's largest, fully operational hydroelectric facility at Grand Coulee Dam located on the Columbia River in eastern Washington state. Data transmitted for control, protection, and communication between this facility's Third Powerplant and 500-kv switchyard are essential for the safe and efficient operation of the Bureau's equipment and the integrity of the connected power systems. To accomplish the reliable, high speed transmission of such data over the relatively long distance between these two locations having unequal ground potential rise (GPR) a fiber optic communication system was installed, tested, and placed into service. The paper discusses the rationale for applying fiber optic technology in this application with emphasis on the related design considerations important in control and protection of this large hydroelectric facility. Brief summaries of hardware used and installation considerations are given. Fundamentals and principles of fiber optic system design are not intended or covered. Discussion of factory and unique field testing, including electromagnetic interference (EMI) induced transient influence and timing tests, is included. Operating experience and projected future use are summarized.

  9. 2013 R&D 100 Award: Movie-mode electron microscope captures nanoscale

    ScienceCinema (OSTI)

    Lagrange, Thomas; Reed, Bryan

    2014-07-21

    A new instrument developed by LLNL scientists and engineers, the Movie Mode Dynamic Transmission Electron Microscope (MM-DTEM), captures billionth-of-a-meter-scale images with frame rates more than 100,000 times faster than those of conventional techniques. The work was done in collaboration with a Pleasanton-based company, Integrated Dynamic Electron Solutions (IDES) Inc. Using this revolutionary imaging technique, a range of fundamental and technologically important material and biological processes can be captured in action, in complete billionth-of-a-meter detail, for the first time. The primary application of MM-DTEM is the direct observation of fast processes, including microstructural changes, phase transformations and chemical reactions, that shape real-world performance of nanostructured materials and potentially biological entities. The instrument could prove especially valuable in the direct observation of macromolecular interactions, such as protein-protein binding and host-pathogen interactions. While an earlier version of the technology, Single Shot-DTEM, could capture a single snapshot of a rapid process, MM-DTEM captures a multiframe movie that reveals complex sequences of events in detail. It is the only existing technology that can capture multiple electron microscopy images in the span of a single microsecond.

  10. Aquatic Ecosystem Enhancement at Mountaintop Mining Sites Symposium

    SciTech Connect (OSTI)

    Black, D. Courtney; Lawson, Peter; Morgan, John; Maggard, Randy; Schor, Horst; Powell, Rocky; Kirk, Ed. J.

    2000-01-12

    Welcome to this symposium which is part of the ongoing effort to prepare an Environmental Impact Statement (EIS) regarding mountaintop mining and valley fills. The EIS is being prepared by the U.S. Environmental Protection Agency, U.S. Army Corps of Engineers, U.S. Office of Surface Mining, and U.S. Fish and Wildlife Service, in cooperation with the State of West Virginia. Aquatic Ecosystem Enhancement (AEE) at mountaintop mining sites is one of fourteen technical areas identified for study by the EIS Interagency Steering Committee. Three goals were identified in the AEE Work Plan: 1. Assess mining and reclamation practices to show how mining operations might be carried out in a way that minimizes adverse impacts to streams and other environmental resources and to local communities. Clarify economic and technical constraints and benefits. 2. Help citizens clarify choices by showing whether there are affordable ways to enhance existing mining, reclamation, mitigation processes and/or procedures. 3. Ide identify data needed to improve environmental evaluation and design of mining projects to protect the environment. Today’s symposium was proposed in the AEE Team Work Plans but coordinated planning for the event began September 15, 1999 when representatives from coal industry, environmental groups and government regulators met in Morgantown. The meeting participants worked with a facilitator from the Canaan Valley Institute to outline plans for the symposium. Several teams were formed to carry out the plans we outlined in the meeting.

  11. Rational design and adaptive management of combination therapies for Hepatitis C virus infection

    SciTech Connect (OSTI)

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.; Kouyos, Roger Dimitri

    2015-06-30

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for <i>de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.

  12. FTIR (Fourier transform infrared) spectrophotometry for thin film monitors: Computer and equipment integration for enhanced capabilities

    SciTech Connect (OSTI)

    Cox, J.N.; Sedayao, J.; Shergill, G.; Villasol, R. ); Haaland, D.M. )

    1990-01-01

    Fourier transform infrared spectrophotometry (FTIR) is a valuable technique for monitoring thin films used in semiconductor device manufacture. Determinations of the constituent contents in borophosphosilicate (BPSG), phosphosilicate (PSG), silicon oxynitride (SiON:H,OH), and spin-on-glass (SOG) thin films are a few applications. Due to the nature of the technique, FTIR instrumentation is one of the most extensively computer-dependent pieces of equipment that is likely to be found in a microelectronics plant. In the role of fab monitor or reactor characterization tool, FTIR instruments can rapidly generate large amounts of data. By linking a local FTIR data station to a remote minicomputer its capabilities are greatly improved. We discuss three caused of enhancement. First, the FTIR in the fab area communicates and interacts in real time with the minicomputer: transferring data segments to it, instructing it to perform sophisticated processing, and returning the result to the operator in the fab. Characterizations of PSG thin films by this approach are discussed. Second, the spectra of large numbers of samples are processed locally. The large database is then transmitted to the minicomputer for study by statistical/graphics software. Results of CVD-reactor spatial profiling experiments for plasma SiON are presented. Third, processing of calibration spectra is performed on the minicomputer to optimize the accuracy and precision of a Partial Least Squares'' analysis mode. This model is then transferred to the data station in the fab. The analysis of BPSG thin films is discussed in this regard. The prospects for fully automated at-line monitoring and for real-time, in-situ monitoring will be discussed. 10 refs., 4 figs.

  13. Enabling Graph Mining in RDF Triplestores using SPARQL for Holistic In-situ Graph Analysis

    SciTech Connect (OSTI)

    Lee, Sangkeun; Sukumar, Sreenivas R; Hong, Seokyong; Lim, Seung-Hwan

    2016-01-01

    The graph analysis is now considered as a promising technique to discover useful knowledge in data with a new perspective. We envi- sion that there are two dimensions of graph analysis: OnLine Graph Analytic Processing (OLGAP) and Graph Mining (GM) where each respectively focuses on subgraph pattern matching and automatic knowledge discovery in graph. Moreover, as these two dimensions aim to complementarily solve complex problems, holistic in-situ graph analysis which covers both OLGAP and GM in a single system is critical for minimizing the burdens of operating multiple graph systems and transferring intermediate result-sets between those systems. Nevertheless, most existing graph analysis systems are only capable of one dimension of graph analysis. In this work, we take an approach to enabling GM capabilities (e.g., PageRank, connected-component analysis, node eccentricity, etc.) in RDF triplestores, which are originally developed to store RDF datasets and provide OLGAP capability. More specifically, to achieve our goal, we implemented six representative graph mining algorithms using SPARQL. The approach allows a wide range of available RDF data sets directly applicable for holistic graph analysis within a system. For validation of our approach, we evaluate performance of our implementations with nine real-world datasets and three different computing environments - a laptop computer, an Amazon EC2 instance, and a shared-memory Cray XMT2 URIKA-GD graph-processing appliance. The experimen- tal results show that our implementation can provide promising and scalable performance for real world graph analysis in all tested environments. The developed software is publicly available in an open-source project that we initiated.

  14. Enabling Graph Mining in RDF Triplestores using SPARQL for Holistic In-situ Graph Analysis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lee, Sangkeun; Sukumar, Sreenivas R; Hong, Seokyong; Lim, Seung-Hwan

    2016-01-01

    The graph analysis is now considered as a promising technique to discover useful knowledge in data with a new perspective. We envi- sion that there are two dimensions of graph analysis: OnLine Graph Analytic Processing (OLGAP) and Graph Mining (GM) where each respectively focuses on subgraph pattern matching and automatic knowledge discovery in graph. Moreover, as these two dimensions aim to complementarily solve complex problems, holistic in-situ graph analysis which covers both OLGAP and GM in a single system is critical for minimizing the burdens of operating multiple graph systems and transferring intermediate result-sets between those systems. Nevertheless, most existingmore » graph analysis systems are only capable of one dimension of graph analysis. In this work, we take an approach to enabling GM capabilities (e.g., PageRank, connected-component analysis, node eccentricity, etc.) in RDF triplestores, which are originally developed to store RDF datasets and provide OLGAP capability. More specifically, to achieve our goal, we implemented six representative graph mining algorithms using SPARQL. The approach allows a wide range of available RDF data sets directly applicable for holistic graph analysis within a system. For validation of our approach, we evaluate performance of our implementations with nine real-world datasets and three different computing environments - a laptop computer, an Amazon EC2 instance, and a shared-memory Cray XMT2 URIKA-GD graph-processing appliance. The experimen- tal results show that our implementation can provide promising and scalable performance for real world graph analysis in all tested environments. The developed software is publicly available in an open-source project that we initiated.« less

  15. New LANL Group M-7 two-stage gun: Double-diaphragm and wrap-around gas breech

    SciTech Connect (OSTI)

    Sheffield, S.A.; Martinez, A.R.

    1992-01-01

    A new two-stage gun is being installed in a high explosive testing facility at Los Alamos National Laboratory for the purpose of subjecting insensitive high explosives to controlled projectile impacts so that shock-to-detonation transition can be studied in detail. This gun has been patterned after guns designed by Alois Stilp at Ernst Mach Institut (EMI) in Freiburg and Wintersweiler, Germany. Several changes were made to adapt the design to our needs. The gun has a 100-mm diameter pump tube and 33-mm and 50-mm diameter launch tubes; both pump and launch tubes are 7.6 m long. We plan to use only helium as the reservoir gas. Large hydraulic clamps hold the gun together in three places during a shot; these are located on both sides of the transition section and at the breech. These clamps make gun conversions to different setups relatively simple, i.e., the two-stage gun can be converted into a single-stage gun. A gas breech has been designed which can be operated in either wrap-around or double-diaphragm mode with a maximum operating pressure of 15,000 psi. Two-stage gun calculations indicate that in the gas breech configuration, projectile velocities up to 4 km/s can be obtained using helium in both the breech and the reservoir. The gun has been fabricated and is being installed at the present time. Testing is expected to begin in early 1993 if the startup difficulties do not become excessive.

  16. New LANL Group M-7 two-stage gun: Double-diaphragm and wrap-around gas breech

    SciTech Connect (OSTI)

    Sheffield, S.A.; Martinez, A.R.

    1992-10-01

    A new two-stage gun is being installed in a high explosive testing facility at Los Alamos National Laboratory for the purpose of subjecting insensitive high explosives to controlled projectile impacts so that shock-to-detonation transition can be studied in detail. This gun has been patterned after guns designed by Alois Stilp at Ernst Mach Institut (EMI) in Freiburg and Wintersweiler, Germany. Several changes were made to adapt the design to our needs. The gun has a 100-mm diameter pump tube and 33-mm and 50-mm diameter launch tubes; both pump and launch tubes are 7.6 m long. We plan to use only helium as the reservoir gas. Large hydraulic clamps hold the gun together in three places during a shot; these are located on both sides of the transition section and at the breech. These clamps make gun conversions to different setups relatively simple, i.e., the two-stage gun can be converted into a single-stage gun. A gas breech has been designed which can be operated in either wrap-around or double-diaphragm mode with a maximum operating pressure of 15,000 psi. Two-stage gun calculations indicate that in the gas breech configuration, projectile velocities up to 4 km/s can be obtained using helium in both the breech and the reservoir. The gun has been fabricated and is being installed at the present time. Testing is expected to begin in early 1993 if the startup difficulties do not become excessive.

  17. Resolution of critical environmental issues with WARP{trademark} wind power systems

    SciTech Connect (OSTI)

    Weisbrich, A.L.; Rainey, D.L.; Burns, R.E.

    1996-11-01

    A modular patented wind power technology, the TARP{trademark} Windframe{trademark}, forms the basis for environmentally complying electric energy generation and power plants. A TARP Windframe provides two highly amplified wind flow fields to a set of two tailored conventional, low risk, small diameter wind turbines. It also serves as a support for the wind turbines, yaw assembly and protective housing for a core tower and other internal sub-systems. Wind Amplified Rotor Platforms (WARP{trademark}) Systems are tall TARP module arrays about a core tower. These intelligent towers can be flexibly and incrementally deployed into multi-megawatt size wind power plants. While heavily building on proven windmill technology, WARP systems may be shown to surpass current technology windmills in all aspects of system characteristics. WARPs have improved features as a result of amplified gearless and shrouded turbine performance, user friendly operation and maintenance, and high reliability and operation and maintenance, and high reliability and low risk due to small, simple and robust dynamic components. Environmental benefits include an order of magnitude less land requirement, absence of bird kill potential, attractive appearance, lower far field noise and EMI/TV interference, and improved rotor safety through containment means. Operation under extreme icing is also afforded due to both rotor shielding and inherent self-sustaining tower anti-icing shielding and inherent self-sustaining tower anti-icing capability. This avoids the large rotor imbalance and ice shedding predicaments of conventional windmills. System components are suited for low cost volume production, ease of transportation, erection and servicing.

  18. Elctronic current transducer for ehv circuits. Final report

    SciTech Connect (OSTI)

    Berkebile, L.E.

    1980-11-01

    As ehv and uhv grow a need arises for better current measuring methods. Conventional live tank current transformers become much larger and more costly as voltage withstand requirements become higher. Better accuracy is desirable as larger power flow occurs on interties between power systems. Improved high frequency response is required for advanced high speed relaying techniques and for current limiter operation. Previous current transducers have fulfilled some, but not all, of these requirements. The objective of this project is to provide an electronic current transducer that meets present and projected requirements. The specific objective of this project was to develop an electric current transducer with (1) amplitude error less than 0.3%; (2) dynamic range of twenty times rated current; (3) 10 kHz frequency response; (4) less than 100 ..mu..s turn on time; (5) digital output; and (6) utilizing fiber optic data transmission for EMI free operation. The project objectives have been met except that turn-on-time is 200 ..mu..s. The transducer developed utilizes a conventional current transformer and shunt to provide a reference signal to the electronic encoding system. The encoder power supply is obtained from a current transformer on the transmission line. No auxiliary power supply is required. The encoded data signal is transmitted serially over a single conductor optical fiber cable to the station control room, a distance of up to 300 m. The signal is decoded and converted to parallel digital output and an analog output signal is reconstructed too. This analog signal provides +-10V output to represent full scale peak line current.

  19. M & V Shootout: Setting the Stage For Testing the Performance of New Energy Baseline

    SciTech Connect (OSTI)

    Touzani, Samir; Custodio, Claudine; Sohn, Michael; Fernandes, Samuel; Granderson, Jessica; Jump, David; Taylor, Cody

    2015-07-01

    Trustworthy savings calculations are critical to convincing investors in energy efficiency projects of the benefit and cost-effectiveness of such investments and their ability to replace or defer supply-side capital investments. However, today’s methods for measurement and verification (M&V) of energy savings constitute a significant portion of the total costs of efficiency projects. They also require time-consuming data acquisition and often do not deliver results until years after the program period has ended. A spectrum of savings calculation approaches are used, with some relying more heavily on measured data and others relying more heavily on estimated or modeled data, or stipulated information. The rising availability of “smart” meters, combined with new analytical approaches to quantifying savings, has opened the door to conducting M&V more quickly and at lower cost, with comparable or improved accuracy. Energy management and information systems (EMIS) technologies, not only enable significant site energy savings, but are also beginning to offer M&V capabilities. This paper expands recent analyses of public-domain, whole-building M&V methods, focusing on more novel baseline modeling approaches that leverage interval meter data. We detail a testing procedure and metrics to assess the performance of these new approaches using a large test dataset. We also provide conclusions regarding the accuracy, cost, and time trade-offs between more traditional M&V and these emerging streamlined methods. Finally, we discuss the potential evolution of M&V to better support the energy efficiency industry through low-cost approaches, and the long-term agenda for validation of building energy analytics.

  20. Real-time condition assessment of RAPTOR telescope systems

    SciTech Connect (OSTI)

    Stull, Chris; Taylor, Stuart; Wren, James; Farrar, Charles; Park, Gyuhae

    2010-11-30

    The RAPid Telescopes for Optical Response (RAPTOR) observatory network consists of several robotic astronomical telescopes primarily designed to search for astrophysical transients called a gamma-ray bursts (GRBs). Although intrinsically bright, GRBs are difficult to detect because of their short duration. Typically, they are first observed by satellites that then relay the coordinates of the GRB to a ground station which, in turn, distributes the coordinates over the internet so that ground based observers can perform follow-up observations. Typically the ground based observations begin after the GRB has ended and only residual emiSSion (the 'afterglow') is left. However, if the satellite relays the GRB coordinates quickly enough, a 'fast' robotic telescope on the ground may be able to catch the GRB in progress. The RAPTOR telescope system is one of only a few in the world to have accomplished this feat. In order to achieve these results, the RAPTOR telescopes must operate autonomously at a high duty-cycle and in peak operating condition. Currently the telescopes are maintained in an ad hoc manner, often in a run-to-failure mode. The RAPTOR project could benefit greatly from a structural health monitoring (SHM) system, especially as more complex units are added to the suite of telescopes. This paper will summarize preliminary results from an SHM study performed on one of the RAPTOR telescopes. Damage scenarios that are of concern and that have been previously observed are first summarized. Then a specific study of damage to the telescope drive mechanism is presented where the data acquisition system is first described. Next, damage detection algorithms are developed with LANL's new publically available software SHMTools and the results of this process are discussed in detail. The paper will conclude with a summary of future planned refinemenls of the RAPTOR SHM system.

  1. Ecophysiology of an uncultivated lineage of Aigarchaeota from an oxic, hot spring filamentous ‘streamer’ community

    SciTech Connect (OSTI)

    Beam, Jacob P.; Jay, Zackary J.; Schmid, Markus C.; Rusch, Douglas B.; Romine, Margaret F.; Jennings, Ryan de M.; Kozubal, Mark A.; Tringe, Susannah G.; Wagner, Michael; Inskeep, William P.

    2015-07-03

    In this study, the candidate archaeal phylum ‘Aigarchaeota’ contains microorganisms from terrestrial and subsurface geothermal ecosystems. The phylogeny and metabolic potential of Aigarchaeota has been deduced from several recent single-cell amplified genomes; however, a detailed description of their metabolic potential and in situ transcriptional activity is absent. Here, we report a comprehensive metatranscriptome-based reconstruction of the in situ metabolism of Aigarchaeota in an oxic, hot spring filamentous ‘streamer’ community. Fluorescence in situ hybridization showed that these newly discovered Aigarchaeota are filamentous, which is consistent with the presence and transcription of an actin-encoding gene. Aigarchaeota filaments are intricately associated with other community members, which include both bacteria (for example, filamentous Thermocrinis spp.) and archaea. Metabolic reconstruction of genomic and metatranscriptomic data suggests that this aigarchaeon is an aerobic, chemoorganoheterotroph with autotrophic potential. A heme copper oxidase complex was identified in the environmental genome assembly and highly transcribed in situ. Potential electron donors include acetate, fatty acids, amino acids, sugars and aromatic compounds, which may originate from extracellular polymeric substances produced by other microorganisms shown to exist in close proximity and/or autochthonous dissolved organic carbon (OC). Transcripts related to genes specific to each of these potential electron donors were identified, indicating that this aigarchaeon likely utilizes several OC substrates. Characterized members of this lineage cannot synthesize heme, and other cofactors and vitamins <i>de novo, which suggests auxotrophy. We propose the name Candidatus ‘Calditenuis aerorheumensis’ for this aigarchaeon, which describes its filamentous morphology and its primary electron acceptor, oxygen.

  2. Canted Undulator Upgrade for GeoSoilEnviroCARS Sector 13 at the Advanced Photon Source

    SciTech Connect (OSTI)

    Sutton, Stephen

    2013-02-02

    Support for the beamline component of the canted undulator upgrade of Sector 13 (GeoSoilEnviroCARS; managed and operated by the University of Chicago) at the Advanced Photon Source (APS; Argonne National Laboratory) was received from three agencies (equally divided): NASA-SRLIDAP (now LARS), NSF-EAR-IF (ARRA) and DOE-Single Investigator Small Group (SISGR). The associated accelerator components (undulators, canted front end) were provided by the APS using DOE-ARRA funding. The intellectual merit of the research enabled by the upgrade lies in advancing our knowledge of the composition, structure and properties of earth materials; the processes they control; and the processes that produce them. The upgrade will facilitate scientific advances in the following areas: high pressure mineral physics and chemistry, non-crystalline and nano-crystalline materials at high pressure, chemistry of hydrothermal fluids, reactions at mineral-water interfaces, biogeochemistry, oxidation states of magmas, flow dynamics of fluids and solids, and cosmochemistry. The upgrade, allowing the microprobe to operate 100% of the time and the high pressure and surface scattering and spectroscopy instruments to receive beam time increases, will facilitate much more efficient use of the substantial investment in these instruments. The broad scientific community will benefit by the increase in the number of scientists who conduct cutting-edge research at GSECARS. The user program in stations 13ID-C (interface scattering) and 13ID-D (laser heated diamond anvil cell and large volume press) recommenced in June 2012. The operation of the 13ID-E microprobe station began in the Fall 2012 cycle (Oct.-Dec 2012). The upgraded canted beamlines double the amount of undulator beam time at Sector 13 and provide new capabilities including extended operations of the X-ray microprobe down to the sulfur K edge and enhanced brightness at high energy. The availability of the upgraded beamlines will advance the

  3. Rapid evaluation and quality control of next generation sequencing data with FaQCs

    SciTech Connect (OSTI)

    Lo, Chien -Chi; Chain, Patrick S. G.

    2014-12-01

    Background: Next generation sequencing (NGS) technologies that parallelize the sequencing process and produce thousands to millions, or even hundreds of millions of sequences in a single sequencing run, have revolutionized genomic and genetic research. Because of the vagaries of any platform's sequencing chemistry, the experimental processing, machine failure, and so on, the quality of sequencing reads is never perfect, and often declines as the read is extended. These errors invariably affect downstream analysis/application and should therefore be identified early on to mitigate any unforeseen effects. Results: Here we present a novel FastQ Quality Control Software (FaQCs) that can rapidly process large volumes of data, and which improves upon previous solutions to monitor the quality and remove poor quality data from sequencing runs. Both the speed of processing and the memory footprint of storing all required information have been optimized via algorithmic and parallel processing solutions. The trimmed output compared side-by-side with the original data is part of the automated PDF output. We show how this tool can help data analysis by providing a few examples, including an increased percentage of reads recruited to references, improved single nucleotide polymorphism identification as well as <i>de novo sequence assembly metrics. Conclusion: FaQCs combines several features of currently available applications into a single, user-friendly process, and includes additional unique capabilities such as filtering the PhiX control sequences, conversion of FASTQ formats, and multi-threading. The original data and trimmed summaries are reported within a variety of graphics and reports, providing a simple way to do data quality control and assurance.

  4. A Universal Model for Nanoporous Carbon Supercapacitors Applicable to Diverse Pore Regimes, Carbons, and Electrolyte

    SciTech Connect (OSTI)

    Sumpter, Bobby G; Huang, Jingsong; Meunier, Vincent

    2008-01-01

    Supercapacitors, commonly called electric double-layer capacitors (EDLCs), are emerging as a novel type of energy storage device with the potential to substitute batteries in applications requiring high power densities. In response to the latest experimental breakthrough in nanoporous carbon supercapacitors, we propose a heuristic theoretical model that takes pore curvature into account as a replacement for the EDLC model which is based on a traditional parallel-plate capacitor. When the pore size is in the mesopore regime (2-50 nm), counterions enter mesoporous carbons and approach the pore wall to form an electric double-cylinder capacitor (EDCC); in the micropore regime (< 2 nm), solvated/desolvated counterions line up along the pore axis to form an electric wire-in-cylinder capacitor (EWCC). In the macropore regime (> 50 nm) where pores are large enough so that the pore curvature is no longer significant, the EDCC model can be reduced naturally to the EDLC model. We present density functional theory calculations and detailed analyses of available experimental data in various pore regimes, showing the significant effects of pore curvature on the supercapacitor properties of nanoporous carbons. It is shown that the EDCC/EWCC model is universal to carbon supercapacitors with diverse carbon materials including activated carbons, template carbons, and novel carbide-derived carbons, and with diverse electrolytes including organic electrolytes such as tetraethylammonium tetrafluoroborate (TEABF4), tetraethylammonium methyl-sulfonate (TEAMS) in acetonitrile, aqueous H2SO4 and KOH electrolytes, and even ionic liquid electrolyte such as 1-ethyl-3-methylimmidazolium bis(trifluromethane-sulfonyl)imide (EMI-TFSI). The EDCC/EWCC model allows the supercapacitor properties to be correlated with pore size, specific surface area, Debye length, electrolyte concentration and dielectric constant, and solute ion size, and may lend a support for the systematic optimization of the

  5. Transuranic (Tru) waste volume reduction operations at a plutonium facility

    SciTech Connect (OSTI)

    Cournoyer, Michael E; Nixon, Archie E; Dodge, Robert L; Fife, Keith W; Sandoval, Arnold M; Garcia, Vincent E

    2010-01-01

    Programmatic operations at the Los Alamos National Laboratory Plutonium Facility (TA 55) involve working with various amounts of plutonium and other highly toxic, alpha-emitting materials. The spread of radiological contamination on surfaces, airborne contamination, and excursions of contaminants into the operator's breathing zone are prevented through use of a variety of gloveboxes (the glovebox, coupled with an adequate negative pressure gradient, provides primary confinement). Size-reduction operations on glovebox equipment are a common activity when a process has been discontinued and the room is being modified to support a new customer. The Actin ide Processing Group at TA-55 uses one-meter-long glass columns to process plutonium. Disposal of used columns is a challenge, since they must be size-reduced to get them out of the glovebox. The task is a high-risk operation because the glass shards that are generated can puncture the bag-out bags, leather protectors, glovebox gloves, and the worker's skin when completing the task. One of the Lessons Learned from these operations is that Laboratory management should critically evaluate each hazard and provide more effective measures to prevent personnel injury. A bag made of puncture-resistant material was one of these enhanced controls. We have investigated the effectiveness of these bags and have found that they safely and effectively permit glass objects to be reduced to small pieces with a plastic or rubber mallet; the waste can then be easily poured into a container for removal from the glove box as non-compactable transuranic (TRU) waste. This size-reduction operation reduces solid TRU waste generation by almost 2% times. Replacing one-time-use bag-out bags with multiple-use glass crushing bags also contributes to reducing generated waste. In addition, significant costs from contamination, cleanup, and preparation of incident documentation are avoided. This effort contributes to the Los Alamos National

  6. Novel apo E-derived ABCA1 agonist peptide (CS-6253) promotes reverse cholesterol transport and induces formation of preβ-1 HDL in vitro

    SciTech Connect (OSTI)

    Hafiane, Anouar; Bielicki, John K.; Johansson, Jan O.; Genest, Jacques; Zhu, Xuewei

    2015-07-24

    Apolipoprotein (apo) mimetic peptides replicate some aspects of HDL function. We have previously reported the effects of compound ATI-5261 on its ability to replicate many functions of native apo A-I in the process of HDL biogenesis. ATI-5261 induced muscle toxicity in wild type C57Bl/6 mice, increased CPK, ALT and AST and increase in triglyceride (Tg) levels. Aromatic phenylalanine residues on the non-polar face of ATI-5261, together with positively charged arginine residues at the lipid-water interface were responsible for these effects. This information was used to create a novel analog (CS-6253) that was non-toxic. We evaluated this peptide designed from the carboxyl terminus of apo E, in its ability to mimic apo A-I functionality. Our data shows that the lipidated particles generated by incubating cells overexpressing ABCA1 with lipid free CS-6253 enhances the rate of ABCA1 lipid efflux with high affinity interactions with native ABCA1 oligomeric forms and plasma membrane micro-domains. Interaction between ABCA1 and lipid free CS-6253 resulted in formation of nascent HDL-CS-6253 particles that are actively remodeled in plasma. Mature HDL-CS-6253 particles deliver cholesterol to liver cells via SR-BI in-vitro. CS-6253 significantly increases cholesterol efflux in murine macrophages and in human THP-1 macrophage-derived foam cells expressing ABCA1. Addition of CS-6253 to plasma dose-dependently displaced apo A-I from α-HDL particles and led to <i>de novo formation of preβ-1 HDL that stimulates ABCA1 dependent cholesterol efflux efficiently. When incubated with human plasma CS-6253 was also found to bind with HDL and LDL and promoted the transfer of cholesterol from HDL to LDL predominantly. Our data shows that CS-6253 mimics apo A-I in its ability to promote ABCA1-mediated formation of nascent HDL particles, and enhances formation of preβ-1 HDL with increase in the cycling of apo A-I between the preβ and α-HDL particles in-vitro. These

  7. Distributed Sensor Coordination for Advanced Energy Systems

    SciTech Connect (OSTI)

    Tumer, Kagan

    2013-07-31

    The ability to collect key system level information is critical to the safe, efficient and reli- able operation of advanced energy systems. With recent advances in sensor development, it is now possible to push some level of decision making directly to computationally sophisticated sensors, rather than wait for data to arrive to a massive centralized location before a decision is made. This type of approach relies on networked sensors (called agents from here on) to actively collect and process data, and provide key control deci- sions to significantly improve both the quality/relevance of the collected data and the as- sociating decision making. The technological bottlenecks for such sensor networks stem from a lack of mathematics and algorithms to manage the systems, rather than difficulties associated with building and deploying them. Indeed, traditional sensor coordination strategies do not provide adequate solutions for this problem. Passive data collection methods (e.g., large sensor webs) can scale to large systems, but are generally not suited to highly dynamic environments, such as ad- vanced energy systems, where crucial decisions may need to be reached quickly and lo- cally. Approaches based on local decisions on the other hand cannot guarantee that each agent performing its task (maximize an agent objective) will lead to good network wide solution (maximize a network objective) without invoking cumbersome coordination rou- tines. There is currently a lack of algorithms that will enable self-organization and blend the efficiency of local decision making with the system level guarantees of global decision making, particularly when the systems operate in dynamic and stochastic environments. In this work we addressed this critical gap and provided a comprehensive solution to the problem of sensor coordination to ensure the safe, reliable, and robust operation of advanced energy systems. The differentiating aspect of the proposed work is in shift- ing the

  8. JBlulce Data Acquisition Software for Macromolecular Crystallography

    Energy Science and Technology Software Center (OSTI)

    2010-06-01

    JBlulce (Java Beam Line Universal Integrated Configuration Environment is a data acquisition software for macromolecular crystallography conforming user interface of the SSRL Blulce that has become a de-factor standard in the field. Besides this interface conformity, JBlulce is a unique system in terms of architecture, speec, capability and osftware implementation. It features only two software layers, the JBlulce clients and the EPICS servers, as compared to three layers present in Blulc and most of similarmore » systems. This layers reduction provides a faster communication with hardware and an easier access to advanced hardware capabilities like on-the-fly scanning. Then JBlulc clients are designed to operate in parallel with the other beamline controls which streamlines the tasks performed by staff such as beamline preparation, maitenance, audting and user assistance. Another distinction is the deployment of multiple plugins that can be written in any programming languag thus involving more staff into the development. further on, JBlulce makes use of unified motion controls allowing for easy scanning and optimizing of any beamline component. Finally, the graphic interface is implemented in Java making full use of rich Java libraries and Jave IDE for debugging. to compare, Blulce user interface is implemented with aging Tcl/tk language providing very restricted capabilities. JBlulce makes full use of the industrial power and wide drivers selection of EPICS in controlling hardware; all hardware commuication is routed via multiple EPICS servers residing on local area network. JBlulce also includes several EPICS State Notation servers aimed at making hardware communication more robust. Besides using EPICS for controlling hardware, JBlulce extensively uses EPICS databases for efficien communications between multiple instances of JBlulce clients and JBlulce pplugins that can run in parallel on different computers. All of the above makes JBlulce one of the biggest

  9. Phase 1 Final Technical Report - MgB2 Synthesis for High Field Performance

    SciTech Connect (OSTI)

    Mohit Bhatia; Peter McIntyre

    2009-11-02

    Accelerator Technology Corp. (ATC) has successfully completed its Phase 1 effort to devel-op rf plasma torch synthesis of MgB2 superconducting powder. The overall objective is to de-velop a way to introduce homogeneous alloying of C and SiC impurities into phase-pure MgB2. Several groups have attained remarkable benefits from such alloying in raising the upper critical field Hc2 from ~14 T to ~30 T (bulk) and ~50 T (thin films). But no one has succeeded in pro-ducing that benefit homogeneously, so that current transport in a practical powder-in-tube (PIT) conductor is largely the same as without the alloying. ATC has conceived the possibility of attaining such homogeneity by passing aerosol suspen-sions of reactant powders through an rf plasma torch, with each reactant transported on a stream-line that heats it to an optimum temperature for the synthesis reaction. This procedure would uniquely access non-equilibrium kinetics for the synthesis reaction, and would provide the possi-bility to separately control the temperature and stoichiometry of each reactant as it enters the mixing region where synthesis occurs. It also facilitates the introduction of seed particles (e.g. nanoscale SiC) to dramatically enhance the rate of the synthesis reaction compared to gas-phase synthesis in rf plasma reported by Canfield and others. During the Phase 1 effort ATC commissioned its 60 kW 5 MHz rf source for a manufactur-ing-scale rf plasma torch. This effort required repair of numerous elements, integration of cooling and input circuits, and tuning of the load characteristics. The effort was successful, and the source has now been tested to ~full power. Also in the Phase 1 effort we encountered a subsidiary but very important problem: the world is running out of the only present supply of phase-pure amorphous boron. The starting boron powder must be in the amorphous phase in order for the synthesis reaction to produce phase-pure MgB2. Even small contamination with crystalline