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  1. GI Ventures | Open Energy Information

    Open Energy Info (EERE)

    Munich, Bavaria, Germany Zip: 80805 Product: Strategic Equity Partner for mid-sized enterprises and entrepreneurs. References: GI Ventures1 This article is a stub. You can help...

  2. GI Power Corporation Limited GIPCL | Open Energy Information

    Open Energy Info (EERE)

    New Delhi, Delhi (NCT), India Zip: 110020 Sector: Wind energy Product: Delhi-based start-up wind project developer. References: GI Power Corporation Limited (GIPCL)1 This...

  3. OR I GI NA L S I GNE D B Y OR I GI NA L S I GNE D B Y

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NA L S I GNE D B Y OR I GI NA L S I GNE D B Y

  4. redMaGiC. Selecting Luminous Red Galaxies from the DES Science Verification Data

    SciTech Connect (OSTI)

    Rozo, E.

    2015-07-20

    We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10-3 (h-1Mpc)-3, and a median photo-z bias (zspec zphoto) and scatter (σz=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

  5. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN E D B Y

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    OR I GI N A L S I GN E D B Y Contract DE-AC27-08RV14800 Modification 068 SF30 Continuation Page, Block 14 Page 2 of 8 Purpose of Modification: The purpose of this modification is to do the following: 1. Definitize the contract Change Order issued in modification 032 to implement the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP), Phase 1. The addition of this new requirement increased the costs of CLIN 1 by $125,855 and increased fee in the amount of $9,439, for a total

  6. Comparison of GiBUU calculations with MiniBooNE pion production data

    SciTech Connect (OSTI)

    Lalakulich, O.; Mosel, U.

    2015-05-15

    Background: Neutrino-induced pion production can give important informationon the axial coupling to nucleon resonances. Furthermore, pion production represents a major background to quasielastic-like events. one pion production data from the MiniBooNE in charged current neutrino scattering in mineral oil appeared higher than expected within conventional theoretical approaches. Purpose: We aim to investigate which model parameters affect the calculated cross section and how they do this. Method: The Giessen Boltzmann–Uehling–Uhlenbeck (GiBUU) model is used for an investigation of neutrino-nucleus reactions. Results: Presented are integrated and differential cross sections for 1π{sup +} and 1π{sup 0} production before and after final state interactions in comparison with the MiniBooNE data. Conclusions: For the MiniBooNE flux all processes (QE, 1π-background, Δ, higher resonance production, DIS) contribute to the observed final state with one pion of a given charge. The uncertainty in elementary pion production cross sections leads to a corresponding uncertainty in the nuclear cross sections. Final state interactions change the shape of the muon-related observables only slightly, but they significantly change the shape of pion distributions.

  7. Dr. J. G. Hwang, President Advanced Technologies and Laboratories...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Focus Group determines a change or interpretation to the HASQAR-D is de minimis (an editorial change or interpretation clarifying but not modifying a requirement - example...

  8. Bob Hwang Director, Transportation Energy Center Sandia National...

    Broader source: Energy.gov (indexed) [DOE]

    ... diagnostics Fuel Air Non-optimal swirl Optimal swirl Fuel ... Over 200,000 pickup trucks sold "In my view, the real power ... and dynamics of flow field in turbulent jet flames. ...

  9. DE-EM-0001971 WIPP M&O G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA Table of Content G.1 TECHNICAL AND ADMINISTRATIVE CORRESPONDENCE/MATTERS .......... 1 G.2 DOE ORGANIZATIONAL PROPERTY MANAGEMENT OFFICER .................... 1 G.3 CONTRACTOR CONTACT ................................................................................. 2 G.4 COST REPORTING PROCEDURES................................................................... 2 DE-EM-0001971 WIPP M&O G-1 PART I - THE SCHEDULE SECTION G

  10. Dr. J. G. Hwang, President Advanced Technologies and Laboratories International, Inc.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dr. Imre Gyuk About Us Dr. Imre Gyuk - Energy Storage Program Manager, Office of Electricity Delivery and Energy Reliability Dr. Imre Gyuk Dr. Imre Gyuk is a Energy Storage Program Manager in the Office of Electricity Delivery and Energy Reliability. Most Recent Energy Department Releases Strategic Plan for Energy Storage Safety December 23 Partnering with Vermont for an Innovative Approach to Resilience November 18 Smoothing the Flow of Renewable Solar Energy in California's Central Valley May

  11. Microsoft Word - gorchakov-gi.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... in Figures 5 and 6 for two ranges of periods. The annual cycle and its second and third harmonic make the basic contribution to the long-period variability of the aerosol content. ...

  12. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN E D B Y

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CONTINATION HEETIREFERENCE NO. OF DOCUMENT BEING CONTINUED AEO COTIUTINS IE DE-AC27-08RV14800/071 2AG OF NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (E) (F) Account code: De-obligating TDD funds for Fluidized Bed Steam Reforming Treatability Fund 01250 Appr Year 2010 Ailottee 34 Reporting Entity 421301 Object Ciass 25200 Program 1111412 Project 0004263 WFO 0000000 Local Use 0000000 Amount:

  13. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN E D B Y

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  14. In-Situ observation of wet oxidation kinetics on Si (100) via...

    Office of Scientific and Technical Information (OSTI)

    Authors: Hussain, Zahid ; Rossi, Massimiliano ; Mun, Bongjin S. ; Enta, Yoshiharu ; Fadley, Charles S. ; Lee, Ki-Suk ; Kim, Sang-Koog ; Shin, Hyun-Joon ; Hussain, Zahid ; Ross, ...

  15. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Niina H. ; Hong, Kunlun ; Han, Youngkyu ; Smith, Gregory S. ; Do, Changwoo November 2015 , ... Youngkyu ; Ahn, Suk-kyun ; Zhang, Zhe ; Smith, Gregory S. ; Do, Changwoo We demonstrate ...

  16. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    inflammation (1) inorganic, organic, physical, and analytical chemistry (1) iron (1) lungs (1) manganese (1) Filter by Author Dai, Sheng (2) Koros, William J. (2) Lee, Jong Suk ...

  17. TO: FILE GiR FROM: SUBJECT: I OWNER(S) Past: Current:

    Office of Legacy Management (LM)

    - '-'-k. FECMED INVOLVE%ENr AT SITE --.---....---....+ Control ---% Health Physics Protec G AECMED managed operations q t Little or None ci AECMED respansible far ...

  18. OR I GI N A L S I GN E D B Y CONTINATION HEETIREFERENCE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CONTINATION HEETIREFERENCE NO OF DOCUMENT BEING CONTINUED AEO DE-AC27-08RV14800/064 2AG OF NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (F)(F Obligated Amount for this Modification: $53, 327, 186.59 New Total Obdigated Amount for this Award: $1, 181,248,170.41 incremental Funded Amount changed: from $1, 127, 920, 983.82 to $1,181,248,170.41 Account code: WRPS Fund 01250 Appr Year 2007 Aiottee 34

  19. Direct Imaging of Antiferromagnetic Vortex States

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Recently, a research team from Berkeley, Korea, and China has taken the first direct image ... Young, and A. Scholl (ALS); C. Hwang (Korea Research Institute of Standards and ...

  20. DE-EM-0001971 WIPP M&O G-i PART I - THE SCHEDULE SECTION G

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    approval"). G.2 DOE ORGANIZATIONAL PROPERTY MANAGEMENT OFFICER The Contractor may use the Organizational Property Management Officer as a point of contact for guidance and...

  1. OR I GI N A L S I GN E D B Y COTNAINSETIREFERENCE NO. OF DOCUMENT BEING CONTINUED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    COTNAINSETIREFERENCE NO. OF DOCUMENT BEING CONTINUED ?AGE OF COTNUTONSEE~DE-AC27-08RV14800/063 12 3 NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (E) (F) $1,126,320, 983.82 to $1,127,920, 983.82 ARRA Fund 06049 Appr Year 2009 Ailottee 34 Reporting Entity 421301 Object Class 25400 Program 1111370 Project 2002110 WFO 0000000 Local Use 0000000 TAS Agency Code 89 TAS Account Code 0253 TAS Subaccount

  2. OR I GI N A L S I GN E D B Y I REEECNO OF DOCUMENT BEING CONTINUED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    I REEECNO OF DOCUMENT BEING CONTINUED [AE OF NAME OF OFFEROR OR CONTRACTOR VW.ASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT ()(B) (C) (D) (E) (F) Incremental Funded Amount changed from $18"124",170.41 to $"191251, 7041 Account code: Work Order No. 00083495, !EWO for Idaho Fund 00911 Appr Year 2010 Al1ottee 34 Reporting Entity 421301 Object Class 25400 Program 1721310 Project 0000000 WFO 0425075 Local use 0000000 Ammnt:

  3. Structure of Bottlebrush Polymers: Simulations and Neutron Scattering...

    Office of Scientific and Technical Information (OSTI)

    Authors: Zhang, Zhe 1 ; Ahn, Suk-Kyun 1 ; Carrillo, Jan-Michael Y 1 ; Wu, Bin 1 ; Hong, Kunlun 1 ; Smith, Gregory Scott 1 ; Do, Changwoo 1 + Show Author Affiliations ...

  4. Tunable Encapsulation Structure of Block Copolymer Coated Single...

    Office of Scientific and Technical Information (OSTI)

    Authors: Han, Youngkyu 1 ; Ahn, Suk-Kyun 1 ; Zhang, Zhe 2 ; Smith, Gregory Scott 1 ; Do, Changwoo 1 + Show Author Affiliations Oak Ridge National Lab. (ORNL), Oak Ridge, ...

  5. HEI Report 133 Characterization of Metals Emitted from Motor...

    National Nuclear Security Administration (NNSA)

    ... the help of Min-Suk Bae. Dr Robert Smith and students at the University of ... Atmos Environ 37:1163-1173. Aust AE, Ball JC, Hu AA, Lighty JS, Smith KR, Straccia AM, ...

  6. ALSNews Vol. 324

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dr. Jeong-Sun Kim's group turned to the ALS for a little help. From left to right: Jane Tanamachi, Jeong-Sun Kim, Hye-Mi Park, George Meigs, Suk-Youl Park, Jeong-Hoh Park,...

  7. Multi-channel polarized thermal emitter (Patent) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    by changing the mutual angle between the orientations of the two gratings. Authors: Lee, Jae-Hwang ; Ho, Kai-Ming ; Constant, Kristen P Publication Date: 2013-07-16 OSTI...

  8. UNIRIB Publications: 2007 Bibliography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    J.H. Hamilton, J.K. Hwang, S. Ilyushkin, A. Korgul, W. Krolas, K. Li, R.D. Page, D. Simpson and J.A. Winger, Phys. Rev. Lett. 98, 212501 (2007) ConferencesMeetings Development...

  9. T U.S. Department of Energy P.O. Box 450, MSIN H6-60

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    U.S. Department of Energy P.O. Box 450, MSIN H6-60 Richland, Washington 99352 AES OCT 1 12012 12-CPM-0 144 Dr. J. G. Hwang, Project Manager Advanced Technologies and Laboratories ...

  10. Direct Imaging of Antiferromagnetic Vortex States

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Arenholz, A. Doran, A.T. Young, A. Scholl, C. Hwang, H.W. Zhao, J. Bokor, and Z.Q. Qiu, "Direct observation of imprinted antiferromagnetic vortex states in CoOFeAg(001) discs,"...

  11. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Grbel, Gerhard (1) Guo, Hongyu (1) Hernndez, Rebeca (1) Hernndez, Rebeca, E-mail: rhernandez@ictp.csic.es, E-mail: aurora.nogales@csic.es (1) Hwang, Ho-Ling (1) Ishikawa, ...

  12. Search for: All records | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    American Physical Society Structural Comparison of n-Type and p-Type LaAlO3SrTiO3 Interfaces Yamamoto, Ryosuke ; Bell, Christopher ; Hikita, Yasuyuki ; Hwang, Harold Y. ;...

  13. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... Van Allen Probes observation and modeling of chorus excitation and propagation during weak ... The global context of the 14 November 2012 storm event Hwang, K. -J. ; Sibeck, D. G. ; ...

  14. Search for: All records | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    ... Van Allen Probes observation and modeling of chorus excitation and propagation during weak ... The global context of the 14 November 2012 storm event Hwang, K. -J. ; Sibeck, D. G. ; ...

  15. The Small Business Conference Small Businesses Don't Want to Miss |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy The Small Business Conference Small Businesses Don't Want to Miss The Small Business Conference Small Businesses Don't Want to Miss December 14, 2010 - 3:53pm Addthis Bill Valdez Bill Valdez Director of Workforce Management Alice Hwang has a lot on her plate. As the CEO and CFO of Advanced Technologies and Laboratories International, Inc. (ATL), a 150 employee technical and management consulting firm located in Germantown, Maryland, Ms. Hwang oversees her company's

  16. UNIRIB Publications: 2006 Bibliography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    C.R. Bingham, I.G. Draby, G. Drafta, C. Goodin, C.J. Gross, J.H. Hamilton, A.A. Hecht, J.K. Hwang, D.T. Joss, A. Krogul, W. Krolas, K. Lagergran, K. Li, M.N. Tantawy, J....

  17. UNIRIB Publications: 2009 Bibliography

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    C.R. Bingham, C.J. Gross, J.H. Hamilton, J.K. Hwang, S. Ilyushkin, A. Korgul, W. Krolas, ... Thomas, D.J. Vieira, J.B. Wilhelmy, G.L. Wilson, CAARI 2008, AIP Conf.Proc. 1090, 724 ...

  18. SSRL HEADLINES - December 2011

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 - December 2011 __________________________________________________________________________ Contents of this Issue: From the Director - Outreach and Support Efforts Science Highlight - Manganese-II Oxidation: A Biotic and Abiotic Process Science Highlight - Characterization of Iron Diazene Complexes in Two Oxidation States Biological SAXS Symposium - A Tribute to Dr. Hiro Tsuruta Awards - Prof. Harold Hwang Named American Physical Society Fellow Announcements - Shipping, Lightsources.org

  19. TECHNOLOGY TRANSFER COORDINATORS

    Office of Energy Efficiency and Renewable Energy (EERE)

    Mark Hartney, Director of the Office of Strategic Planning, SLAC, discussed technology transfer at SLAC. Bob Hwang, Director, Transportation Energy Center, Combustion Research Facility, SNL presented on technology transfer at SNL. Elsie Quaite-Randall, Chief Technology Transfer Officer, Innovation and Partnerships Office, LBNL, presented on technology transfer at LBNL. Richard A. Rankin, Director, Industrial Partnerships Office and Economic Development Office (Interim), LLNL, presented on technology transfer at LLNL.

  20. Super Cool Appliance Design Wins Student Competition | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Super Cool Appliance Design Wins Student Competition Super Cool Appliance Design Wins Student Competition August 23, 2012 - 2:44pm Addthis The winners of the Max Tech and Beyond competition -- a team of University of Maryland students -- designed and built a prototype for a wall unit air conditioner that showed more than 30 percent energy savings when tested in a lab. | Photo courtesy of Yunho Hwang, University of Maryland. The winners of the Max Tech and Beyond competition -- a team of

  1. SASW Measurements at Hanford

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    H - Spectral Analysis of Surface Waves Hanford Site-Wide Probabilistic Seismic Hazard Analysis (PSHA): Seismic Shear Wave Velocity Profiling at Hanford, WA SASW Testing and Analysis Procedures, V s Profiles, Sensitivity Studies and Responses to Technical Integration Team Questions for Pacific Northwest National Laboratory Richland, WA by Kenneth H. Stokoe, II Yin-Cheng Lin Sungmoon Hwang, and Julia Roberts May 7, 2014 Geotechnical Engineering Report GR14-1 Geotechnical Engineering Center Civil

  2. Response of High-Tc Superconductor Metamaterials to High Intensity THz

    Office of Scientific and Technical Information (OSTI)

    Radiation (Conference) | SciTech Connect Response of High-Tc Superconductor Metamaterials to High Intensity THz Radiation Citation Details In-Document Search Title: Response of High-Tc Superconductor Metamaterials to High Intensity THz Radiation Authors: Grady, Nathaniel [1] ; Perkins Jr., Bradford G. [2] ; Hwang, Harold Y. [2] ; Brandt, Nate [2] ; Torchinsky, Darius [2] ; Singh, Ranjan [1] ; Yan, Li [3] ; Jia, Quanxi [1] ; Trugman, Stuart A. [1] ; Taylor, Antoinette J. [1] ; Nelson, Keith

  3. PROJECT PROFILE: Amtech Systems, Inc. (Incubator 10) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Amtech Systems, Inc. (Incubator 10) PROJECT PROFILE: Amtech Systems, Inc. (Incubator 10) Project Title: Efficiency Enhancement in c-Si Solar cells by Introducing Fixed-charge into SiNx Passivation Film Using a Novel Low-cost Plasma Charging Method Funding Opportunity: SunShot Technology to Market (Incubator 10) SunShot Subprogram: Technology to Market Location: Tempe, Arizona Amount Awarded: $930,664 Awardee Cost Share: $236,000 Project Investigator: Jeong-Mo (James) Hwang Amtech is developing a

  4. DE-AC27-I1ORVI15051 Modification A009

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    I1ORVI15051 Modification A009 Page 2 of 6 A. The purpose of this modification is to make an equitable adjustment to contract cost relevant to transition cost and the stop work order dated November 27, 2009, and modify the period of performance as detailed below: Reference: 1. ATL Letter dated May 24, 2010, from J.G. Hwang, ATL, to D.A. Gallegos, ORP, "CLIN 1 TRANSITION COST OVERRUN PROPOSAL (Contract Number DE-AC27-1I0RV 1505 1) Background: The contract was awarded on November 20, 2009, and

  5. DOE Announces Webinars on Hiring Veterans for Solar Energy Jobs...

    Broader source: Energy.gov (indexed) [DOE]

    vets, how the post-911 GI Bill can aid in the hiring ... Practices, National Residential Efficiency Measures ... and Anticipated Fuel Cell Electric Vehicles, Net Metering ...

  6. ARM - Publications: Science Team Meeting Documents: Seasonal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the seasonal variation of land cover which is dominated by the agricultural land use, primarily winter wheat production. http:gi.ssec.wisc.eduairsknutesonindex.html...

  7. Volatilization of selected organic compounds from a creosote-waste land-treatment facility. Master's thesis

    SciTech Connect (OSTI)

    Scott, E.J.

    1989-01-01

    The purpose of this research was to evaluate the emissions of volatile and semi-volatile compounds which are constituents of a complex creosote waste from laboratory simulations of a land treatment system to assess the potential human exposure to hazardous compounds from this source. In addition, the Thibodeaux-Hwang Air Emission Release Rate (AERR) model was evaluated for its use in predicting emission rates of hazardous constituents of creosote wood preservative waste from land treatment facilities. A group of hazardous volatile and semi-volatile constituents present in the creosote waste was selected for evaluation in this study and included a variety of polynuclear aromatic hydrocarbons (PNA's), phenol, and chlorinated and substituted phenols.

  8. PART I - THE SCHEDULE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G Contract No. DE-AC06-09RL14728 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ......

  9. Microsoft Word - Section G _Rev 01-23-2006_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G Contract No. DE-AC06-05RL14655 M014 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CORRESPONDENCE PROCEDURES......

  10. PART I - THE SCHEDULE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G Contract No. DE-AC27-08RV14800 Modification No. 020 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION...

  11. PART I - THE SCHEDULE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G Contract No. DE-AC06-08RL14788 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ......

  12. Cours-IX/Clavin2015.key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Nonlinear stochastic equation) 4 P.Clavin IX IX-2) Turbulent diffusion Einstein 1905 G.I Taylor 1922 Taylor's di usion coecient x 2 (t) 2 t 0 dt t 0 d v(t )v(t ) integration...

  13. 06-DataManagement-Gerhardt.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The compute and storage systems 2014 ProducGI, MatComp, Planck global scratch 4 PB project 5 PB home 250 TB 65 PB stored, 240 PB capacity, 4 0 y ...

  14. Final Technical Report: Integrated Distribution-Transmission...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... a tool was created in Python, and multiple feeders provided by two western U.S. utilities (under NDA with NREL) in SynerGi and CYMDIST format were converted to GridLAB-D format. ...

  15. --No Title--

    U.S. Energy Information Administration (EIA) Indexed Site

    by Source, 2008 (Dollars per Million Btu) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass...

  16. Energy Review

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    M iggl-003504t11l)sar Energy Review 8 M. IM W I -W All* r ;ai*i el I gi In this issue: Energy-related housing characteristics Propane-provider fleet survey Ordering...

  17. A=17B (1993TI07)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and its ground state probably has J 32- (1974BO05, 1986AJ04) in agreement with the shell model (1992WA22). It has been observed in several heavy ion reactions (1987GI05,...

  18. A=7H (1974AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4AJ01) (Not illustrated) A search for 7H in 7Li(π-, π+)7H was unsuccessful (1965GI10). See also (1968CE1A

  19. A=7H (1979AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9AJ01) (Not illustrated) A search for 7H in 7Li(π-, π+)7H was unsuccessful (1965GI10). See also (1975BE31, 1977SP1B; theor.

  20. Enhancement of [alpha]-Helix Mimicry by an [alpha/beta]-Peptide...

    Office of Scientific and Technical Information (OSTI)

    Authors: Johnson, Lisa M. ; Mortenson, David E. ; Yun, Hyun Gi ; Horne, W. Seth ; Ketas, Thomas J. ; Lu, Min ; Moore, John P. ; Gellman, Samuel H. 1 ; UMD-NJ) 2 ; Weill-Med) ...

  1. Interpolating the Coulomb phase of little string theory

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lin, Ying -Hsuan; Shao, Shu -Heng; Wang, Yifan; Yin, Xi

    2015-12-03

    We study up to 8-derivative terms in the Coulomb branch effective action of (1,1) little string theory, by collecting results of 4-gluon scattering amplitudes from both perturbative 6D super-Yang-Mills theory up to 4-loop order, and tree-level double scaled little string theory (DSLST). In previous work we have matched the 6-derivative term from the 6D gauge theory to DSLST, indicating that this term is protected on the entire Coulomb branch. The 8-derivative term, on the other hand, is unprotected. In this paper we compute the 8-derivative term by interpolating from the two limits, near the origin and near the infinity onmore » the Coulomb branch, numerically from SU(k) SYM and DSLST respectively, for k=2,3,4,5. We discuss the implication of this result on the UV completion of 6D SYM as well as the strong coupling completion of DSLST. As a result, we also comment on analogous interpolating functions in the Coulomb phase of circle-compactified (2,0) little string theory.« less

  2. Upper limit to magnetism in LaAIO3/SrTiO3 heterostructures

    SciTech Connect (OSTI)

    Fitzsimmons, Michael R.; Hengartner, N. W.; Singh, S.; Zhernenkov, M.; Bruno, F. Y.; Santamaria, J.; Brinkman, A.; Huijben, M.; Molegraaf, H.; de la Venta, J.; Schuller, Ivan K.

    2012-02-27

    In 2004 Ohtomo and Hwang reported unusually high conductivity in LaAl03 and SrTi03 bilayer samples. Since then, metallic conduction, superconductivity, magnetism, and coexistence of superconductivity and ferromagnetism have been attributed to LaAl03/SrTi03 interfaces. Very recently, two studies have reported large magnetic moments attributed to interfaces from measurement techniques that are unable to distinguish between interfacial and bulk magnetism. Consequently, it is imperative to perform magnetic measurements that by being intrinsically sensitive to interface magnetism are impervious to experimental artifacts suffered by bulk measurements. Using polarized neutron reflectometry we measured the neutron spin dependent reflectivity from four LaAl03/SrTi03 superlattices. Our results indicate the upper limit for the magnetization averaged over the lateral dimensions of the sample induced by an 11 T magnetic field at 1.7 K is less than 2 G. SQUID magnetometry of the neutron superlattice samples sporadically finds an enhanced moment (consistent with past reports), possibly due to experimental artifacts. These observations set important restrictions on theories which imply a strongly enhanced magnetism at the interface between LaAI03 and SrTi03.

  3. Regulation of chloroplast biogenesis: the immutans mutant of Arabidopsis

    SciTech Connect (OSTI)

    Rodermel, Steven

    2015-11-16

    The immutans (im) variegation mutant of Arabidopsis is an ideal model to gain insight into factors that control chloroplast biogenesis. im defines the gene for PTOX, a plastoquinol terminal oxidase that participates in control of thylakoid redox. Here, we report that the im defect can be suppressed during the late stages of plant development by gigantea (gi2), which defines the gene for GIGANTEA (GI), a central component of the circadian clock that plays a poorly-understood role in diverse plant developmental processes. imgi2 mutants are late-flowering and display other well-known phenotypes associated with gi2, such as starch accumulation and resistance to oxidative stress. We show that the restoration of chloroplast biogenesis in imgi2 is caused by a developmental-specific de-repression of cytokinin signaling that involves crosstalk with signaling pathways mediated by gibberellin (GA) and SPINDLY (SPY), a GA response inhibitor. Suppression of the plastid defect in imgi2 is likely caused by a relaxation of excitation pressures in developing plastids by factors contributed by gi2, including enhanced rates of photosynthesis and increased resistance to oxidative stress. Interestingly, the suppression phenotype of imgi can be mimicked by crossing im with the starch accumulation mutant, sex1, perhaps because sex1 utilizes pathways similar to gi. We conclude that our studies provide a direct genetic linkage between GIGANTEA and chloroplast biogenesis, and we construct a model of interactions between signaling pathways mediated by gi, GA, SPY, cytokinins, and sex1 that are required for chloroplast biogenesis.

  4. Fail Safe Design for Large Capacity Lithium-ion Batteries

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fail Safe Design for Large Capacity Lithium-ion Batteries NREL Commercialization & Tech Transfer Webinar March 27, 2011 Gi-Heon Kim gi-heon.kim@nrel.gov John Ireland, Kyu-Jin Lee, Ahmad Pesaran Kandler Smith kandler.smith@nrel.gov Source: A123 Source: GM NATIONAL RENEWABLE ENERGY LABORATORY Challenges for Large LIB Systems 2 * Li-ion batteries are flammable, require expensive manufacturing to reduce defects * Small-cell protection devices do not work for large systems * Difficult to detect

  5. A=20C (1998TI06)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98TI06) (Not illustrated) 20C has been observed in heavy ion projectile fragmentation reactions (1987GI05, 1990MU06, 1991MU19) and in proton-induced target-fragmentation reactions (1987VI13, 1988MU08, 1993WOZZ). The atomic mass excess is 37.560 ± 0.200 MeV (1995AU04). It is then stable with respect to 19C + n and 18C + 2n by 3.3 and 3.5 MeV, respectively. β-delayed neutron emission has been observed (1987GI05, 1990MU06, 1991MU19). The half life and neutron emission probability have been

  6. A=20N (1998TI06)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98TI06) (Not illustrated) 20N is particle stable. Its atomic mass excess is 21.770 ± 0.050 MeV (1995AU04). It has been observed in heavy-ion transfer (1989OR03) and projectile fragmentation reactions (1987GI05, 1988DUZT, 1988MU08, 1990MU06, 1991OR01) and in target fragmentation reactions (1988WO09, 1991RE02, 1993WOZZ). See also the review (1988VI1D). Mass measurements were reported in (1987GI05, 1988WO09, 1989OR03, 1991OR01, 1993WOZZ). Nuclear matter rms radii have been derived from

  7. Microsoft Word - Section G _Rev 01-23-2006_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G Contract No. DE-AC06-05RL14655 M014 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CORRESPONDENCE PROCEDURES.............................................................................................1 G.2 CONTRACT ADMINISTRATION .......................................................................................................1 G.3 BILLING INSTRUCTIONS

  8. A=14Be (1991AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    +)14B reaction (1984GI09), in the interaction of 30 MeVA 18O ions with 181Ta (1986CU01) and in the spallation of thorium by 800 MeV protons (1988WO09). See also (1986AJ01). ...

  9. Revised Manuscript

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    + ) 14 B reaction (1984GI09), in the interaction of 30 MeVA 18 O ions with 181 Ta (1986CU01) and in the spallation of thorium by 800 MeV protons (1988WO09). See also (1986AJ01). ...

  10. A=10Li (1988AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MeV) corresponds to the ground state. 10Lig.s. would then be unbound with respect to breakup into 9Li + n by 0.80 0.25 MeV: see (1979AJ01). See also (1986GI10, 1987AB15),...

  11. Radiation-induced complications in prostate cancer patients treated with radiotherapy

    SciTech Connect (OSTI)

    Azuddin, A. Yusof; Rahman, I. Abdul; Mohamed, F.; Siah, N. J.; Saadc, M.; Ismail, F.

    2014-09-03

    The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60{sub rectum}, rectal mean dose and NTCP{sub rectum} with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.

  12. High-Dose-Rate Brachytherapy Alone for Localized Prostate Cancer in Patients at Moderate or High Risk of Biochemical Recurrence

    SciTech Connect (OSTI)

    Hoskin, Peter; Rojas, Ana; Lowe, Gerry; Bryant, Linda; Ostler, Peter; Hughes, Rob; Milner, Jessica; Cladd, Helen

    2012-03-15

    Purpose: To evaluate genitourinary (GU) and gastrointestinal (GI) morbidity and biochemical control of disease in patients with localized prostate adenocarcinoma treated with escalating doses per fraction of high-dose rate brachytherapy alone. Methods and Materials: A total of 197 patients were treated with 34 Gy in four fractions, 36 Gy in four fractions, 31.5 Gy in three fractions, or 26 Gy in two fractions. Median follow-up times were 60, 54, 36, and 6 months, respectively. Results: Incidence of early Grade {>=} 3 GU morbidity was 3% to 7%, and Grade 4 was 0% to 4%. During the first 12 weeks, the highest mean International Prostate Symptom Score (IPSS) value was 14, and between 6 months and 5 years it was 8. Grade 3 or 4 early GI morbidity was not observed. The 3-year actuarial rate of Grade 3 GU was 3% to 16%, and was 3% to 7% for strictures requiring surgery (4-year rate). An incidence of 1% Grade 3 GI events was seen at 3 years. Late Grade 4 GU or GI events were not observed. At 3 years, 99% of patients with intermediate-risk and 91% with high-risk disease were free of biochemical relapse (log-rank p = 0.02). Conclusions: There was no significant difference in urinary and rectal morbidity between schedules. Biochemical control of disease in patients with intermediate and high risk of relapse was good.

  13. A=15O (70AJ04)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    corresponding to 15O*(5.19, 5.25, 6.15, 6.79, 6.86). See also (MA65Q). Gamma ray branding ratios are shown in Table 15.22 (in PDF or PS) (WA65J, GI68C). Lifetime measurements...

  14. Refueliing Infrastructure for Alternative Fuel Vehicles: Lessons...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    st tr ra at ti io on n a an nd d N Ne et tw wo or rk ki in ng g R Re ec ce ep pt ti io on n ( (l li ig gh ht t f fa ar re e) ) THURSDAY, APRIL 3 7:00 am R Re eg gi is st tr ra at ...

  15. 9Be Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    S-factor Ecm 0.16 - 1.87 S(E) X4 01242012 2011GI05 9Be(, n): for n1 0.3 - 7.9 linear scale, log scale 06182012 1968DA05 9Be(, n): excitation function at 0...

  16. Contract Number DE-EM0003383, Mod 014 Section G Workers' Compensation Claims Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 Section G Workers' Compensation Claims Services Penser North America, Inc. G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION PLAN TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ................................................................................ 1 G.2 RL-G-1001 SUBMISSION OF REQUEST FOR PAYMENT - SUPPLIES OR SERVICES......................................................................................................................... 1 G.3 MODIFICATION AUTHORITY

  17. Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

    SciTech Connect (OSTI)

    Pugh, Thomas J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek; Nguyen, Quyhn Nhu; Mathai, Benson [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ron; Sahoo, Narayan; Gillin, Michael; Johnson, Jennifer L.; Amos, Richard A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Scripps Proton Therapy Center, San Diego, California (United States); Mahmood, Usama; Kuban, Deborah A.; Frank, Steven J.; Hoffman, Karen E.; McGuire, Sean E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Andrew K., E-mail: aklee@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: To report quality of life (QOL)/toxicity in men treated with proton beam therapy for localized prostate cancer and to compare outcomes between passively scattered proton therapy (PSPT) and spot-scanning proton therapy (SSPT). Methods and Materials: Men with localized prostate cancer enrolled on a prospective QOL protocol with a minimum of 2 years' follow-up were reviewed. Comparative groups were defined by technique (PSPT vs SSPT). Patients completed Expanded Prostate Cancer Index Composite questionnaires at baseline and every 3-6 months after proton beam therapy. Clinically meaningful differences in QOL were defined as ?0.5 baseline standard deviation. The cumulative incidence of modified Radiation Therapy Oncology Group grade ?2 gastrointestinal (GI) or genitourinary (GU) toxicity and argon plasma coagulation were determined by the Kaplan-Meier method. Results: A total of 226 men received PSPT, and 65 received SSPT. Both PSPT and SSPT resulted in statistically significant changes in sexual, urinary, and bowel Expanded Prostate Cancer Index Composite summary scores. Only bowel summary, function, and bother resulted in clinically meaningful decrements beyond treatment completion. The decrement in bowel QOL persisted through 24-month follow-up. Cumulative grade ?2 GU and GI toxicity at 24 months were 13.4% and 9.6%, respectively. There was 1 grade 3 GI toxicity (PSPT group) and no other grade ?3 GI or GU toxicity. Argon plasma coagulation application was infrequent (PSPT 4.4% vs SSPT 1.5%; P=.21). No statistically significant differences were appreciated between PSPT and SSPT regarding toxicity or QOL. Conclusion: Both PSPT and SSPT confer low rates of grade ?2 GI or GU toxicity, with preservation of meaningful sexual and urinary QOL at 24 months. A modest, yet clinically meaningful, decrement in bowel QOL was seen throughout follow-up. No toxicity or QOL differences between PSPT and SSPT were identified. Long-term comparative results in a larger patient

  18. Transjugular Endovascular Recanalization of Splenic Vein in Patients with Regional Portal Hypertension Complicated by Gastrointestinal Bleeding

    SciTech Connect (OSTI)

    Luo, Xuefeng; Nie, Ling; Wang, Zhu; Tsauo, Jiaywei; Tang, Chengwei; Li, Xiao

    2013-05-02

    PurposeRegional portal hypertension (RPH) is an uncommon clinical syndrome resulting from splenic vein stenosis/occlusion, which may cause gastrointestinal (GI) bleeding from the esophagogastric varices. The present study evaluated the safety and efficacy of transjugular endovascular recanalization of splenic vein in patients with GI bleeding secondary to RPH.MethodsFrom December 2008 to May 2011, 11 patients who were diagnosed with RPH complicated by GI bleeding and had undergone transjugular endovascular recanalization of splenic vein were reviewed retrospectively. Contrast-enhanced computed tomography revealed splenic vein stenosis in six cases and splenic vein occlusion in five. Etiology of RPH was chronic pancreatitis (n=7), acute pancreatitis with pancreatic pseudocyst (n=2), pancreatic injury (n=1), and isolated pancreatic tuberculosis (n=1).ResultsTechnical success was achieved in 8 of 11 patients via the transjugular approach, including six patients with splenic vein stenosis and two patients with splenic vein occlusion. Two patients underwent splenic vein venoplasty only, whereas four patients underwent bare stents deployment and two covered stents. Splenic vein pressure gradient (SPG) was reduced from 21.57.3 to 2.91.4mmHg after the procedure (P<0.01). For the remaining three patients who had technical failures, splenic artery embolization and subsequent splenectomy was performed. During a median follow-up time of 17.5 (range, 334)months, no recurrence of GI bleeding was observed.ConclusionsTransjugular endovascular recanalization of splenic vein is a safe and effective therapeutic option in patients with RPH complicated by GI bleeding and is not associated with an increased risk of procedure-related complications.

  19. "Omics of the mammalian gut new insights into function

    SciTech Connect (OSTI)

    Lamendella, Regina; Verberkmoes, Nathan C; Jansson, Janet

    2012-01-01

    To understand the role of gut microbes in host health, it is imperative to probe their genetic potential, expression, and ecological status. The current high-throughput sequencing revolution, in addition to advances in mass spectrometry-based proteomics, have recently enabled deep access to these complex environments, and are revealing important insights into the roles of the gastrointestinal (GI) microbiota in host physiology and health. This review discusses examples of how the integration of cutting-edge meta-omics technologies are providing new knowledge about the relationships between host health status in mammals and the microbes inhabiting the GI tract. In addition, we address some promises that these techniques hold for future therapeutic and diagnostic applications.

  20. A=19C (1987AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7AJ02) (See the Isobar Diagram for 19C) 19C has been observed in the 0.8 GeV proton bombardment of thorium (1986VI09) and in the fragmentation of 60 MeV/A argon ions (1987GI1E). The mass excess is 32.30 ± 0.24 MeV (1986VI09), 32.95 ± 0.42 MeV (1987GI1E): the weighted mean is 32.46 ± 0.21 MeV. 19C is then stable with respect to decay into 18C + n by 0.53 MeV and into 17C + 2n by 4.72 MeV. The calculated half-life of 19C is 1.2 × 10-2 sec (1984KL06). See also (1978AJ03, 1985WA02, 1986AN07,

  1. A=19C (1995TI07)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    95TI07) (See the Isobar Diagram for 19C) 19C has been observed in the 0.8 GeV proton bombardment of thorium (1986VI09, 1988WO09) and in the fragmentation of 66 MeV/A argon ions (1987GI05) and in 44 MeV/A 22Ne on 181Ta, and in 112 MeV/A 20Ne on 12C (1994RAZW, 1995OZ02). The mass excess adopted by (1993AU05) is 32.23 ± 0.11 MeV. See also (1986VI09, 1987GI05, 1988WO09, 1991OR01). 19C is then stable with respect to decay into 18C + n by 0.16 MeV and into 17C + 2n by 4.35 MeV. The half-life was

  2. A=20N (1987AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7AJ02) (Not illustrated) 20N is particle stable. Its atomic mass excess is 21.64 ± 0.26 MeV (1986VI09), 22.20 ± 0.36 MeV (1986GI10), 21.62 ± 0.14 MeV (1987GI1E). We adopt 21.62 ± 0.14 MeV. 20N is then stable with respect to 19N + n by 2.32 MeV (see 19N). The half-life of 20N is 100+30-20 msec, Pn ~ 61% (1987MU1J; prelim.). See also (1984KL06; theor.). See also (1985PIZZ, 1986PI09), (1983WI1A, 1984HI1A, 1986AN07, 1986GU1D) and (1983ANZQ; theor.

  3. PowerPoint Presentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Arid Lands Green Infrastructure Regional Examples + Tour Green Infrastructure and Low-Impact Design for Stormwater Management July 12, 2012 Erin English, PE LEED AP Biohabitats/Natural Systems International Principles of GI/LID Think like a watershed Infiltrate, evapotranspirate and slow down runoff Minimize erosion and sediment transport Treat stormwater close to the source Use pervious areas for stormwater Treatment Water Harvesting within the landscape Regional Examples * Emerging approach in

  4. GRAVITATIONAL INSTABILITY OF ROTATING, PRESSURE-CONFINED, POLYTROPIC GAS DISKS WITH VERTICAL STRATIFICATION

    SciTech Connect (OSTI)

    Kim, Jeong-Gyu; Kim, Woong-Tae; Seo, Young Min; Hong, Seung Soo E-mail: wkim@astro.snu.ac.kr E-mail: sshong@astro.snu.ac.kr

    2012-12-20

    We investigate the gravitational instability (GI) of rotating, vertically stratified, pressure-confined, polytropic gas disks using a linear stability analysis as well as analytic approximations. The disks are initially in vertical hydrostatic equilibrium and bounded by a constant external pressure. We find that the GI of a pressure-confined disk is in general a mixed mode of the conventional Jeans and distortional instabilities, and is thus an unstable version of acoustic-surface-gravity waves. The Jeans mode dominates in weakly confined disks or disks with rigid boundaries. On the other hand, when the disk has free boundaries and is strongly pressure confined, the mixed GI is dominated by the distortional mode that is surface-gravity waves driven unstable under their own gravity and thus incompressible. We demonstrate that the Jeans mode is gravity-modified acoustic waves rather than inertial waves and that inertial waves are almost unaffected by self-gravity. We derive an analytic expression for the effective sound speed c{sub eff} of acoustic-surface-gravity waves. We also find expressions for the gravity reduction factors relative to a razor-thin counterpart that are appropriate for the Jeans and distortional modes. The usual razor-thin dispersion relation, after correcting for c{sub eff} and the reduction factors, closely matches the numerical results obtained by solving a full set of linearized equations. The effective sound speed generalizes the Toomre stability parameter of the Jeans mode to allow for the mixed GI of vertically stratified, pressure-confined disks.

  5. Microsoft Word - Attachment G1G 10-1-2012.docx

    Office of Environmental Management (EM)

    G1 APPENDIX G TECHNICAL SPECIFICATIONS PANEL CLOSURE SYSTEM WASTE ISOLATION PILOT PLANT CARLSBAD, NEW MEXICO Waste Isolation Pilot Plant Hazardous Waste Permit October 1, 2012 (This page intentionally blank) Waste Isolation Pilot Plant Hazardous Waste Permit October 1, 2012 PERMIT ATTACHMENT G1G Page G1G-i ATTACHMENT G1 APPENDIX G TECHNICAL SPECIFICATIONS PANEL CLOSURE SYSTEM WASTE ISOLATION PILOT PLANT CARLSBAD, NEW MEXICO TABLE OF CONTENTS DIVISION 1 - GENERAL REQUIREMENTS

  6. Fuel Cell Freeze Startup and Landscape of FC Freeze Patents

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Freeze Startup and Landscape of FC Freeze Patents DOE Workshop on Fuel Cell Operations at Sub-Freezing Temperatures Phoenix, Arizona February 1, 2005 Ahmad Pesaran Tony Markel Gi-Heon Kim Keith Wipke 2 Content * NREL's FC Freeze Project * Patent Search - Initial Results * System Perspective Evaluation * Summary * Appendix (Supporting Slides) 3 NREL's FY05 FC Freeze Project As part of a Task in the FY05 AOP to DOE's HFCIT. Objective * Investigate and evaluate strategies for rapid startup of PEM

  7. Resources for Veterans | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Resources for Veterans Resources for Veterans The CNS Veterans Program STEM initiative is a valuable resource for our nation's veterans. Check out some of the other resources available. In Tennessee Anderson County, Tennessee, Veterans Office Tennessee Department of Veterans Affairs Tennessee Lottery Tuition Support Program In Texas Texas State Veterans Benefits Texas Lottery Tuition Support Program Across the U.S. Student Veterans of America National Resource Directory Today's GI Bill website

  8. OneTouch 4.0 Scanned Documents

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - - - o THE FRESHWATER DECAPOD CRUSTACEANS (Pa/aemon/dae, Cambar/dae) OF THE SAVANNAH RIVER PLANT, SOUTH CAROLINA ..* ..' by Horton H. Hobbs III James H. Thorp and Gi Ibert E. Anderson A Publ ication of the Savannah River Plant, National Environmental Research Park Program - - - - - - - - - - - - - - - - - - - - THE FRESHWATER DECAPOD CRUSTACEANS (PALAEMONIDAE, CAMBARIDAE) OF THE SAVANNAH RIVER PLANT, SOUTH CAROLINA (U. S. - ERDA) by H. H. Hobbs III Department of Biology, Wittenberg University

  9. Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer

    SciTech Connect (OSTI)

    Wang, Jingya [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan; Palmer, Matthew [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hofstetter, Wayne L.; Swisher, Stephen G. [Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D.; Komaki, Ritsuko; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H., E-mail: SHLin@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-08-01

    Purpose: While trimodality therapy for esophageal cancer has improved patient outcomes, surgical complication rates remain high. The goal of this study was to identify modifiable factors associated with postoperative complications after neoadjuvant chemoradiation. Methods and Materials: From 1998 to 2011, 444 patients were treated at our institution with surgical resection after chemoradiation. Postoperative (pulmonary, gastrointestinal [GI], cardiac, wound healing) complications were recorded up to 30 days postoperatively. Kruskal-Wallis tests and ?{sup 2} or Fisher exact tests were used to assess associations between continuous and categorical variables. Multivariate logistic regression tested the association between perioperative complications and patient or treatment factors that were significant on univariate analysis. Results: The most frequent postoperative complications after trimodality therapy were pulmonary (25%) and GI (23%). Lung capacity and the type of radiation modality used were independent predictors of pulmonary and GI complications. After adjusting for confounding factors, pulmonary and GI complications were increased in patients treated with 3-dimensional conformal radiation therapy (3D-CRT) versus intensity modulated radiation therapy (IMRT; odds ratio [OR], 2.018; 95% confidence interval [CI], 1.104-3.688; OR, 1.704; 95% CI, 1.03-2.82, respectively) and for patients treated with 3D-CRT versus proton beam therapy (PBT; OR, 3.154; 95% CI, 1.365-7.289; OR, 1.55; 95% CI, 0.78-3.08, respectively). Mean lung radiation dose (MLD) was strongly associated with pulmonary complications, and the differences in toxicities seen for the radiation modalities could be fully accounted for by the MLD delivered by each of the modalities. Conclusions: The radiation modality used can be a strong mitigating factor of postoperative complications after neoadjuvant chemoradiation.

  10. Molecular Analysis of Asymptomatic Bacteriuria Escherichia coli Strain VR50 Reveals Adaptation to the Urinary Tract by Gene Acquisition

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Beatson, Scott A.; Ben Zakour, Nouri L.; Totsika, Makrina; Forde, Brian M.; Watts, Rebecca E.; Mabbett, Amanda N.; Szubert, Jan M.; Sarkar, Sohinee; Phan, Minh-Duy; Peters, Kate M.; et al

    2015-05-01

    Urinary tract infections (UTIs) are among the most common infectious diseases of humans, with Escherichia coli for >80% of all cases. One extreme of UTI is asymptomatic bacteriuria (ABU), which occurs as an asymptomatic carrier state that resembles commensalism. Here, to understand the evolution and molecular mechanisms that underpin ABU, the genome of the ABU E. coli strain VR50 was sequenced. Analysis of the complete genome indicated that it most resembles E. coli K-12, with the addition of a 94-kb genomic island (GI-VR50-pheV), eight prophages, and multiple plasmids. GI-VR50-pheV has a mosaic structure and contains genes encoding a number ofmore » UTI-associated virulence factors, namely, Afa (afimbrial adhesin), two autotransporter proteins (Ag43 and Sat), and aerobactin. We demonstrated that the presence of this island in VR50 confers its ability to colonize the murine bladder, as a VR50 mutant with GI-VR50-pheV deleted was attenuated in a mouse model of UTI in vivo. We established that Afa is the island-encoded factor responsible for this phenotype using two independent deletion (Afa operon and AfaE adhesin) mutants. E. coli VR50afa and VR50afaE displayed significantly decreased ability to adhere to human bladder epithelial cells. In the mouse model of UTI, VR50afa and VR50afaE displayed reduced bladder colonization compared to wild-type VR50, similar to the colonization level of the GI-VR50-pheV mutant. In conlusion, our study suggests that E. coli VR50 is a commensal-like strain that has acquired fitness factors that facilitate colonization of the human bladder.« less

  11. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Development of A Small Instrument To Investigate Airborne Aerosols Catherine F. Cahill Associate Professor Geophysical Institute and Department of Chemistry & Biochemistry University of Alaska Fairbanks Phone: 907-474-6905 Email: ffcfc@uaf.edu October 16, 2008 Gregory W. Walker Manager Poker Flat Research Range Geophysical Institute University of Alaska Fairbanks Phone: 907-455-2102 Email: Gregory.Walker@gi.alaska.edu In support of the US Army Research Laboratory Conducting Marine Mammal

  12. A=12C (68AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    68AJ02) (See Energy Level Diagrams for 12C) GENERAL: See also Table 12.7 [Table of Energy Levels] (in PDF or PS). Shell model: (KU56, PE56A, KU57A, ME60D, TA60L, WE60B, BA61N, TR61, NA63A, VI63A, AM64, CL64, GI64C, GI64D, NE64C, BA65E, CO65I, FA65C, NE65, GI66A, HA66F, VA66A, YO66A, CO67M, EV67A, KU67B, HI68A). Collective model: (BA59F, BR59M, CL61D, CL62G, GO62I, WA62, GO63G, BR64Z, VO64C, ST65C, UB65, UB65A, VO65A, BO66H, DA66G, DR66B, KR66A, BA67D, BO67D, BO67J, BR67, KR67, LA67F, LA67M,

  13. NRG Oncology Radiation Therapy Oncology Group 0822: A Phase 2 Study of Preoperative Chemoradiation Therapy Using Intensity Modulated Radiation Therapy in Combination With Capecitabine and Oxaliplatin for Patients With Locally Advanced Rectal Cancer

    SciTech Connect (OSTI)

    Hong, Theodore S.; Moughan, Jennifer; Garofalo, Michael C.; Bendell, Johanna; Berger, Adam C.; Oldenburg, Nicklas B.E.; Anne, Pramila Rani; Perera, Francisco; Jabbour, Salma K.; Nowlan, Adam; DeNittis, Albert; Crane, Christopher

    2015-09-01

    Purpose: To evaluate the rate of gastrointestinal (GI) toxicity of neoadjuvant chemoradiation with capecitabine, oxaliplatin, and intensity modulated radiation therapy (IMRT) in cT3-4 rectal cancer. Methods and Materials: Patients with localized, nonmetastatic T3 or T4 rectal cancer <12 cm from the anal verge were enrolled in a prospective, multi-institutional, single-arm study of preoperative chemoradiation. Patients received 45 Gy with IMRT in 25 fractions, followed by a 3-dimensional conformal boost of 5.4 Gy in 3 fractions with concurrent capecitabine/oxaliplatin (CAPOX). Surgery was performed 4 to 8 weeks after the completion of therapy. Patients were recommended to receive FOLFOX chemotherapy after surgery. The primary endpoint of the study was acute grade 2 to 5 GI toxicity. Seventy-one patients provided 80% probability to detect at least a 12% reduction in the specified GI toxicity with the treatment of CAPOX and IMRT, at a significance level of .10 (1-sided). Results: Seventy-nine patients were accrued, of whom 68 were evaluable. Sixty-one patients (89.7%) had cT3 disease, and 37 (54.4%) had cN (+) disease. Postoperative chemotherapy was given to 42 of 68 patients. Fifty-eight patients had target contours drawn per protocol, 5 patients with acceptable variation, and 5 patients with unacceptable variations. Thirty-five patients (51.5%) experienced grade ≥2 GI toxicity, 12 patients (17.6%) experienced grade 3 or 4 diarrhea, and pCR was achieved in 10 patients (14.7%). With a median follow-up time of 3.98 years, the 4-year rate of locoregional failure was 7.4% (95% confidence interval [CI]: 1.0%-13.7%). The 4-year rates of OS and DFS were 82.9% (95% CI: 70.1%-90.6%) and 60.6% (95% CI: 47.5%-71.4%), respectively. Conclusion: The use of IMRT in neoadjuvant chemoradiation for rectal cancer did not reduce the rate of GI toxicity.

  14. The complete mitochondrial sequence of the"living fossil" Tricholepidion gertschi: structure, phylogenetic implications, and the description of a novel A/T asymmetrical bias

    SciTech Connect (OSTI)

    Nardi, F.; Frati, F.; Carapelli, A.; Dallai, R.; Boore, J.

    2002-06-23

    the evolution and differentiation of the most basal hexapod groups, including Tricholepidion. Mitochondrial genomics, that is analysis of various features of the mitochondrial genome such as gene order and the analysis of the concatenated sequence of its genes, has proved to be a very powerful tool for the study of ancient phylogenetic relationships (Boore, 2000; Boore and Brown, 1995; Boore and Brown, 1998; Garcia-Machado et al., 1999; Hwang et al., 2001; Nardi et al., 2001), and its application seems to be appropriate for the problem under study ((Nardi et al., 2001), this study). In addition, complete mitochondrial sequences, with the advent of automatic sequencing tools, are accumulating rapidly, but there is a strong bias towards the better known or economically important groups, while only two sequences have been produced for the more basal, and evolutionarily more intriguing, hexapod orders. The complete sequence of the mitochondrial genome of Tricholepidion gertschi is the second among apterygotans, following the collembolan T.bielanensis (Nardi et al., 2001).

  15. The Superoxide Reductase from the Early Diverging Eukaryote Giardia Intestinalis

    SciTech Connect (OSTI)

    Cabelli, D.E.; Testa, F.; Mastronicola, D.; Bordi, E.; Pucillo, L.P.; Sarti, P.; Saraiva, L.M.; Giuffre, A.; Teixeira, M.

    2011-10-15

    Unlike superoxide dismutases (SODs), superoxidereductases (SORs) eliminate superoxide anion (O{sub 2}{sup {sm_bullet}-}) not through its dismutation, but via reduction to hydrogen peroxide (H{sub 2}O{sub 2}) in the presence of an electron donor. The microaerobic protist Giardia intestinalis, responsible for a common intestinal disease in humans, though lacking SOD and other canonical reactive oxygen species-detoxifying systems, is among the very few eukaryotes encoding a SOR yet identified. In this study, the recombinant SOR from Giardia (SOR{sub Gi}) was purified and characterized by pulse radiolysis and stopped-flow spectrophotometry. The protein, isolated in the reduced state, after oxidation by superoxide or hexachloroiridate(IV), yields a resting species (T{sub final}) with Fe{sup 3+} ligated to glutamate or hydroxide depending on pH (apparent pK{sub a} = 8.7). Although showing negligible SOD activity, reduced SOR{sub Gi} reacts with O{sub 2}{sup {sm_bullet}-} with a pH-independent second-order rate constant k{sub 1} = 1.0 x 10{sup 9} M{sup -1} s{sup -1} and yields the ferric-(hydro)peroxo intermediate T{sub 1}; this in turn rapidly decays to the T{sub final} state with pH-dependent rates, without populating other detectable intermediates. Immunoblotting assays show that SOR{sub Gi} is expressed in the disease-causing trophozoite of Giardia. We propose that the superoxide-scavenging activity of SOR in Giardia may promote the survival of this air-sensitive parasite in the fairly aerobic proximal human small intestine during infection.

  16. Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction

    SciTech Connect (OSTI)

    Massey, Veronica L.; Stocke, Kendall S.; Schmidt, Robin H.; Tan, Min; Ajami, Nadim; Neal, Rachel E.; Petrosino, Joseph F.; Barve, Shirish; Arteel, Gavin E.

    2015-05-01

    Arsenic (As) tops the ATSDR list of hazardous environmental chemicals and is known to cause liver injury. Although the concentrations of As found in the US water supply are generally too low to directly damage the liver, subhepatotoxic doses of As sensitize the liver to experimental NAFLD. It is now suspected that GI microbiome dysbiosis plays an important role in development of NALFD. Importantly, arsenic has also been shown to alter the microbiome. The purpose of the current study was to test the hypothesis that the prebiotic oligofructose (OFC) protects against enhanced liver injury caused by As in experimental NAFLD. Male C57Bl6/J mice were fed low fat diet (LFD), high fat diet (HFD), or HFD containing oligofructose (OFC) during concomitant exposure to either tap water or As-containing water (4.9 ppm as sodium arsenite) for 10 weeks. HFD significantly increased body mass and caused fatty liver injury, as characterized by an increased liver weight-to-body weight ratio, histologic changes and transaminases. As observed previously, As enhanced HFD-induced liver damage, which was characterized by enhanced inflammation. OFC supplementation protected against the enhanced liver damage caused by As in the presence of HFD. Interestingly, arsenic, HFD and OFC all caused unique changes to the gut flora. These data support previous findings that low concentrations of As enhance liver damage caused by high fat diet. Furthermore, these results indicate that these effects of arsenic may be mediated, at least in part, by GI tract dysbiosis and that prebiotic supplementation may confer significant protective effects. - Highlights: • Arsenic (As) enhances liver damage caused by a high-fat (HFD) diet in mice. • Oligofructose protects against As-enhanced liver damage caused by HFD. • As causes dysbiosis in the GI tract and exacerbates the dysbiosis caused by HFD. • OFC prevents the dysbiosis caused by HFD and As, increasing commensal bacteria.

  17. Toward an ontology framework supporting the integration of geographic information with modeling and simulation for critical infrastructure protection

    SciTech Connect (OSTI)

    Ambrosiano, John J; Bent, Russell W; Linger, Steve P

    2009-01-01

    Protecting the nation's infrastructure from natural disasters, inadvertent failures, or intentional attacks is a major national security concern. Gauging the fragility of infrastructure assets, and understanding how interdependencies across critical infrastructures affect their behavior, is essential to predicting and mitigating cascading failures, as well as to planning for response and recovery. Modeling and simulation (M&S) is an indispensable part of characterizing this complex system of systems and anticipating its response to disruptions. Bringing together the necessary components to perform such analyses produces a wide-ranging and coarse-grained computational workflow that must be integrated with other analysis workflow elements. There are many points in both types of work flows in which geographic information (GI) services are required. The GIS community recognizes the essential contribution of GI in this problem domain as evidenced by past OGC initiatives. Typically such initiatives focus on the broader aspects of GI analysis workflows, leaving concepts crucial to integrating simulations within analysis workflows to that community. Our experience with large-scale modeling of interdependent critical infrastructures, and our recent participation in a DRS initiative concerning interoperability for this M&S domain, has led to high-level ontological concepts that we have begun to assemble into an architecture that spans both computational and 'world' views of the problem, and further recognizes the special requirements of simulations that go beyond common workflow ontologies. In this paper we present these ideas, and offer a high-level ontological framework that includes key geospatial concepts as special cases of a broader view.

  18. Fuel Cell Freeze Startup and Landscape of FC Freeze Patents | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Startup and Landscape of FC Freeze Patents Fuel Cell Freeze Startup and Landscape of FC Freeze Patents Presentation by Ahmad Pesaran, Tony Markel, Gi-Heon Kim, Keith Wipke to DOE's Fuel Cell Operations at Sub-Freezing Temperatures Workshop held February 1-5, 2005 in Phoenix, Arizona. 12_pesaran_landscape.pdf (1.52 MB) More Documents & Publications Stationary Applications and Freeze/Thaw Challenges DOE Program/Targets and Workshop Objectives Startup of PEFC Stacks From Sub-Freezing

  19. Douglas Jacobsen! NERSC User Services Group

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Services Group Using Modules at NERSC --- 1 --- September 10, 2013 NERSC Supported Software * NERSC p rovides a w ide r ange o f s cien=fic a nd c omputer programming s o@ware t o u sers - Scien)fic A pplica)ons: V ASP, A mber, N AMD, ABySS, ... - Compilers: p gi, i ntel, g cc, c ray - Scrip)ng L anguages: perl, p ython, R * and p ackages f or e ach! - SoIware L ibraries: b las/lapack ( MKL), b oost, h df5, n etcdf, ... - U)li)es: gnuplot, g it, m ercurial, 7 zip, c make, . .. - Debuggers &

  20. Richard Gerber, Helen He, Zhengji Zhao, David Turner NUG Monthly

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Helen He, Zhengji Zhao, David Turner NUG Monthly Meeting --- 1 --- NUG M onthly M ee-ng November 13, 2014 Agenda * Tuesday's Q uarterly M aintenance * Hopper and Edison Status Updates * NUGEX Elec-ons * NUG 2 015 M ee-ng P lanning * Training U pdate * User Survey * Queue C ommiJee T opics --- 2 --- Quarterly Maintenance Summary" David Turner, NERSC User Services --- 3 --- Maintenance: November 11, 2014 * Quarterly m aintenance - Originally t o a ccommodate J GI s equencer o pera;ons -

  1. MEMORANDUM TO: FILE

    Office of Legacy Management (LM)

    ' a 7 > 3gI, q OH.I-r7.-I (jt' , ""7 MEMORANDUM TO: FILE FROM: ' 'Y OIL&i cz ,,,',, -------we- SUBJECT: SITE NAME: _____ CITY:-AQY&- --------------e----e-- OWNER(S) Owner contacted n yes =urr="t: ----- -Llz2-:---,-- -----___ &,&/4$- '1 :) ' if yes, data contacted ------------- TYPE OF OPERATION ----------------- a Research t Development lti- Facility Type 0 Production scale testing a Manufacturing 5 University 0 Research Organization 0 Government Sponsored

  2. 06-DataManagement-Gerhardt.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New User Training! July 15, 2014 Data Management at NERSC Where Do I Put My Data? --- 2 --- * Overview o f N ERSC fi le s ystems - Local v s. G lobal - Permanent v s. P urged * HPSS A rchive S ystem - What i s i t a nd h ow t o u se i t * Data S haring NERSC File Systems --- 3 --- The compute and storage systems 2014 Produc<on C lusters Carver, P DSF, J GI, MatComp, Planck /global/ scratch 4 PB /project 5 PB /home 250 TB 65 PB stored, 240 PB capacity, 4 0 y ears o f community d ata HPSS 16 x

  3. Joint Facilities User Forum on Data Intensive Computing Lessons Learned

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    User Forum on Data Intensive Computing Lessons Learned - NERSC/JGI Partnership Kjiersten Fagnan, NERSC User Services/JGI --- 1 --- June 1 7, 2 013 Outline * Overview o f N ERSC/JGI P artnership - DOE J GI b ackground - Team o verview - Compute r esources * CompuBng S trategic P lan - JGI G oals - NERSC G oals * Lessons Learned --- 2 --- DOE Joint Genome Institute 3 DOE JGI, Serving as a genomic user facility in support of the DOE missions: * Walnut Creek, CA facility opened in 1999 * 250

  4. A=8B (1988AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8AJ01) (See Energy Level Diagrams for 8B) GENERAL: See also (1984AJ01) and Table 8.9 [Table of Energy Levels] (in PDF or PS) here. Model calculations: (1983SH38). Special states: (1982PO12, 1988KH03). Complex reactions involving 8B: (1982AL08, 1983OL1A, 1984GR08, 1986HA1B, 1987TAZU, 1988AR05, 1988KI05). Astrophysical questions: (1984HA1B, 1985BO1E, 1985GI1C, 1985KL1A, 1985LA1C, 1988BA86). Reactions involving pions: (1983SP06). Hypernuclei: (1983SH38). Other topics: (1985AN28). Ground state of

  5. DOE/EIA-0376(2014)

    Gasoline and Diesel Fuel Update (EIA)

    376(2014) June 2016 State Energy Price and Expenditure Estimates 1970 Through 2014 2014 Price and Expenditure Summary Tables S U M M A R I E S U.S. Energy Information Administration | State Energy Data 2014: Prices and Expenditures 3 Table E1. Primary Energy, Electricity, and Total Energy Price Estimates, 2014 (Dollars per Million Btu) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass Total g,h,i Distillate Fuel

  6. Coordinate-Space Hartree-Fock-Bogoliubov Solvers for Super fluid Fermi

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems in Large Boxes | Argonne Leadership Computing Facility Coordinate-Space Hartree-Fock-Bogoliubov Solvers for Super fluid Fermi Systems in Large Boxes Authors: Pei, J.C., Fann, G.I., Harrison, R.J., Nazarewicz, W., Hill, J., Galindo, D., Jia, J. The self-consistent Hartree-Fock-Bogoliubov problem in large boxes can be solved accurately in the coordinate space with the recently developed solvers HFB-AX (2D) and MADNESS-HFB (3D). This is essential for the description of superfluid Fermi

  7. SU-E-T-335: Transit Dosimetry for Verification of Dose Delivery Using Electronic Portal Imaging Device (EPID)

    SciTech Connect (OSTI)

    Baek, T; Chung, E; Lee, S; Yoon, M

    2014-06-01

    Purpose: To evaluate the effectiveness of transit dose, measured with an electronic portal imaging device (EPID), in verifying actual dose delivery to patients. Methods: Plans of 5 patients with lung cancer, who received IMRT treatment, were examined using homogeneous solid water phantom and inhomogeneous anthropomorphic phantom. To simulate error in patient positioning, the anthropomorphic phantom was displaced from 5 mm to 10 mm in the inferior to superior (IS), superior to inferior (SI), left to right (LR), and right to left (RL) directions. The transit dose distribution was measured with EPID and was compared to the planed dose using gamma index. Results: Although the average passing rate based on gamma index (GI) with a 3% dose and a 3 mm distance-to-dose agreement tolerance limit was 94.34 % for the transit dose with homogeneous phantom, it was reduced to 84.63 % for the transit dose with inhomogeneous anthropomorphic phantom. The Result also shows that the setup error of 5mm (10mm) in IS, SI, LR and SI direction can Result in the decrease in values of GI passing rates by 1.3% (3.0%), 2.2% (4.3%), 5.9% (10.9%), and 8.9% (16.3%), respectively. Conclusion: Our feasibility study suggests that the transit dose-based quality assurance may provide information regarding accuracy of dose delivery as well as patient positioning.

  8. Stable, concentrated solutions of high molecular weight polyaniline and articles therefrom

    DOE Patents [OSTI]

    Mattes, Benjamin R.; Wang, Hsing-Lin

    1999-11-09

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (between 15% and 30% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  9. Stable, concentrated solutions of high molecular weight polyaniline and articles therefrom

    DOE Patents [OSTI]

    Mattes, Benjamin R.; Wang, Hsing-Lin

    2000-01-01

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (>15% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  10. Method for preparing polyaniline fibers

    DOE Patents [OSTI]

    Mattes, Benjamin R.; Wang, Hsing-Lin

    2000-01-01

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (>15% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  11. The relationship between leaf area growth and biomass accumulation in Arabidopsis thaliana

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Weraduwage, Sarathi M.; Chen, Jin; Anozie, Fransisca C.; Morales, Alejandro; Weise, Sean E.; Sharkey, Thomas D.

    2015-04-09

    Leaf area growth determines the light interception capacity of a crop and is often used as a surrogate for plant growth in high-throughput phenotyping systems. The relationship between leaf area growth and growth in terms of mass will depend on how carbon is partitioned among new leaf area, leaf mass, root mass, reproduction, and respiration. A model of leaf area growth in terms of photosynthetic rate and carbon partitioning to different plant organs was developed and tested with Arabidopsis thaliana L. Heynh. ecotype Columbia (Col-0) and a mutant line, gigantea-2 (gi-2), which develops very large rosettes. Data obtained from growthmore » analysis and gas exchange measurements was used to train a genetic programming algorithm to parameterize and test the above model. The relationship between leaf area and plant biomass was found to be non-linear and variable depending on carbon partitioning. The model output was sensitive to the rate of photosynthesis but more sensitive to the amount of carbon partitioned to growing thicker leaves. The large rosette size of gi-2 relative to that of Col-0 resulted from relatively small differences in partitioning to new leaf area vs. leaf thickness.« less

  12. The relationship between leaf area growth and biomass accumulation in Arabidopsis thaliana

    SciTech Connect (OSTI)

    Weraduwage, Sarathi M.; Chen, Jin; Anozie, Fransisca C.; Morales, Alejandro; Weise, Sean E.; Sharkey, Thomas D.

    2015-04-09

    Leaf area growth determines the light interception capacity of a crop and is often used as a surrogate for plant growth in high-throughput phenotyping systems. The relationship between leaf area growth and growth in terms of mass will depend on how carbon is partitioned among new leaf area, leaf mass, root mass, reproduction, and respiration. A model of leaf area growth in terms of photosynthetic rate and carbon partitioning to different plant organs was developed and tested with Arabidopsis thaliana L. Heynh. ecotype Columbia (Col-0) and a mutant line, gigantea-2 (gi-2), which develops very large rosettes. Data obtained from growth analysis and gas exchange measurements was used to train a genetic programming algorithm to parameterize and test the above model. The relationship between leaf area and plant biomass was found to be non-linear and variable depending on carbon partitioning. The model output was sensitive to the rate of photosynthesis but more sensitive to the amount of carbon partitioned to growing thicker leaves. The large rosette size of gi-2 relative to that of Col-0 resulted from relatively small differences in partitioning to new leaf area vs. leaf thickness.

  13. The Gut Microbiota: Ecology and Function

    SciTech Connect (OSTI)

    Willing, B.P.; Jansson, J.K.

    2010-06-01

    The gastrointestinal (GI) tract is teeming with an extremely abundant and diverse microbial community. The members of this community have coevolved along with their hosts over millennia. Until recently, the gut ecosystem was viewed as black box with little knowledge of who or what was there or their specific functions. Over the past decade, however, this ecosystem has become one of fastest growing research areas of focus in microbial ecology and human and animal physiology. This increased interest is largely in response to studies tying microbes in the gut to important diseases afflicting modern society, including obesity, allergies, inflammatory bowel diseases, and diabetes. Although the importance of a resident community of microorganisms in health was first hypothesized by Pasteur over a century ago (Sears, 2005), the multiplicity of physiological changes induced by commensal bacteria has only recently been recognized (Hooper et al., 2001). The term 'ecological development' was recently coined to support the idea that development of the GI tract is a product of the genetics of the host and the host's interactions with resident microbes (Hooper, 2004). The search for new therapeutic targets and disease biomarkers has escalated the need to understand the identities and functions of the microorganisms inhabiting the gut. Recent studies have revealed new insights into the membership of the gut microbial community, interactions within that community, as well as mechanisms of interaction with the host. This chapter focuses on the microbial ecology of the gut, with an emphasis on information gleaned from recent molecular studies.

  14. Microbial community proteomics for characterizing the range of metabolic functions and activities of human gut microbiota

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xiong, Weili; Abraham, Paul E.; Li, Zhou; Pan, Chongle; Robert L. Hettich

    2015-01-01

    We found that the human gastrointestinal (GI) tract is a complex, dynamic ecosystem that consists of a carefully tuned balance of human host and microbiota membership. The microbiome component is not insignificant, but rather provides important functions that are absolutely critical to many aspects of human health, including nutrient transformation and absorption, drug metabolism, pathogen defense, and immune system development. Microbial community proteomics (sometimes referred to as metaproteomics) provides a powerful approach to measure the range and details of human gut microbiota functions and metabolic activities, revealing information about microbiome development and stability especially with regard to human health vs.more » disease states. In most cases, both microbial and human proteins are extracted from fecal samples and then measured by the high performance MS-based proteomics technology. We review the field of human gut microbiome community proteomics, with a focus on the experimental and informatics considerations involved in characterizing systems that range from low complexity defined model gut microbiota in gnotobiotic mice, to the simple gut microbiota in the GI tract of newborn infants, and finally to the complex gut microbiota in adults. Moreover, the current state-of-the-art in experimental and bioinformatics capabilities for community proteomics enable a detailed measurement of the gut microbiota, yielding valuable insights into the broad functional profiles of even complex microbiota. Future developments are likely to expand into improved analysis throughput and coverage depth, as well as post-translational modification characterizations.« less

  15. Cryogenic expansion machine

    DOE Patents [OSTI]

    Pallaver, Carl B.; Morgan, Michael W.

    1978-01-01

    A cryogenic expansion engine includes intake and exhaust poppet valves each controlled by a cam having adjustable dwell, the valve seats for the valves being threaded inserts in the valve block. Each cam includes a cam base and a ring-shaped cam insert disposed at an exterior corner of the cam base, the cam base and cam insert being generally circular but including an enlarged cam dwell, the circumferential configuration of the cam base and cam dwell being identical, the cam insert being rotatable with respect to the cam base. GI CONTRACTUAL ORIGIN OF THE INVENTION The invention described herein was made in the course of, or under, a contract with the UNITED STATES ENERGY RESEARCH AND DEVELOPMENT ADMINISTRATION.

  16. Method of fabricating conducting oxide-silicon solar cells utilizing electron beam sublimation and deposition of the oxide

    DOE Patents [OSTI]

    Feng, Tom; Ghosh, Amal K.

    1979-01-01

    In preparing tin oxide and indium tin oxide-silicon heterojunction solar cells by electron beam sublimation of the oxide and subsequent deposition thereof on the silicon, the engineering efficiency of the resultant cell is enhanced by depositing the oxide at a predetermined favorable angle of incidence. Typically the angle of incidence is between 40.degree. and 70.degree. and preferably between 55.degree. and 65.degree. when the oxide is tin oxide and between 40.degree. and 70.degree. when the oxide deposited is indium tin oxide. gi The Government of the United States of America has rights in this invention pursuant to Department of Energy Contract No. EY-76-C-03-1283.

  17. A=10C (1979AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9AJ01) (See Energy Level Diagrams for 10C) GENERAL: See also (1974AJ01) and Table 10.22 [Table of Energy Levels] (in PDF or PS). Model calculations: (1974IR04, 1976IR1B). Special reactions (See also reaction 2 in (1974AJ01).): (1973BA81, 1974RI1A, 1975BA1Q, 1976BE1K, 1976BU16, 1977AR06). Pion reactions (See also reactions 3 and 9 here.): (1975GI1B, 1975RE01, 1977HO1B, 1977WA02, 1978AM01). Astrophysical questions: (1972PA1C, 1976VI1A, 1977SI1D). Other topics: (1974IR04, 1976IR1B, 1976VO1C).

  18. A=12Be (1975AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    75AJ02) (See the Isobar Diagram for 12Be) GENERAL: See also (1968AJ02) and Table 12.1 [Table of Energy Levels] (in PDF or PS). Special reactions: (1965GI10, 1969AR13, 1971AR02, 1972VO06, 1973KO1D). General review: (1974CE1A). Theoretical papers: (1971DO1F, 1972ST1C, 1973WI15, 1974IR04, 1974MA1E). Mass of 12Be: The Q-value of the 14C(18O, 20Ne)12Be reaction [-15.77 ± 0.05 MeV] (1974BA15) leads to an atomic mass excess of 25.05 ± 0.05 MeV; that for the 7Li(7Li, 2p)12Be reaction [Q = -9.71 ±

  19. A=12Be (1990AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    90AJ01) (See Energy Level Diagrams for 12Be) GENERAL: See also (1985AJ01) and Table 12.1 [Table of Energy Levels] (in PDF or PS) here. General theoretical papers: (1984FR13, 1985AN28, 1985BA51, 1985WI1B, 1986WI04, 1987BL18, 1987GI1C, 1987SA15, 1987YA16, 1988RU01, SU88C, 1989BE03). Hypernuclei: (1984IW1B, 1984YA04, 1985BE31, 1985GA1C, 1985IK1A, 1985WA1N, 1985YA01, 1985YA07, 1986BA1W, 1986BI1G, 1986DO1B, 1986GA14, 1986GA33, 1986GA1H, 1986HA26, 1986MA1J, 1986ME1F, 1986MI1N, 1986PO1H, 1986YA1T,

  20. A=12C (1975AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    75AJ02) (See Energy Level Diagrams for 12C) GENERAL: See also (1968AJ02) and Table 12.8 [Table of Energy Levels] (in PDF or PS). Shell model: (1967SV1A, 1968BA1L, 1968DR1B, 1968FA1B, 1968FU1B, 1968GO01, 1968GU1C, 1968HA11, 1968RO1G, 1969GU1E, 1969GU03, 1969IK1A, 1969LA26, 1969MO1F, 1969SA1A, 1969SV1A, 1969WA06, 1969WO05, 1970AR21, 1970BE26, 1970BO33, 1970BO1J, 1970CO1H, 1970DE1F, 1970DO1A, 1970EI06, 1970GI11, 1970GU11, 1970KH01, 1970KO04, 1970KR1D, 1970LO1C, 1970RE1G, 1970RU1A, 1970RY1A,

  1. A=12C (1980AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0AJ01) (See Energy Level Diagrams for 12C) GENERAL: See also (1975AJ02) and Table 12.7 [Table of Energy Levels] (in PDF or PS). Shell model: (1974BO1P, 1975BI05, 1975BO27, 1975FR06, 1975GI1C, 1975MU13, 1975WA30, 1976BA24, 1977CA02, 1977CA08, 1977GR02, 1977JA14, 1978FU13, 1978MU04, 1978SV01, 1979LO1F). Collective and deformed models: (1974BO1P, 1975BO27, 1975KI21, 1975LE14, 1975MC15, 1975SO07, 1976GL1C, 1976PA25, 1977CA08, 1977TH03, 1977UE01, 1977VI03, 1979MA1J). Cluster and alpha particle

  2. A=12C (1985AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5AJ01) (See Energy Level Diagrams for 12C) GENERAL: See also (1980AJ01) and Table 12.6 [Table of Energy Levels] (in PDF or PS). Shell model: (1977ME05, 1978RA1B, 1979HA59, 1979IN05, 1980CA12, 1980GI05, 1980HA35, 1980OH07, 1981AM08, 1981BO1Y, 1981DE2G, 1981LU1B, 1981RA06, 1982AR03, 1982BA52, 1982BR08, 1983VA31, 1984DE04, 1984VA06). Deformed models: (1979UE03, 1980BA1T, 1980BA44, 1980CA12, 1980FU1H, 1981DE2G, 1981RA06, 1981SE03, 1982AS03, 1982BR08, 1982KU1K, 1982SA1U, 1983LO04, 1983SA12,

  3. A=13N (1986AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6AJ01) (See Energy Level Diagrams for 13N) GENERAL: See also (1981AJ01) and Table 13.14 [Table of Energy Levels] (in PDF or PS). Nuclear models: (1983SH38). Special states: (1981KO1Q, 1983AU1B, 1983WI15, 1984RO05). Electromagnetic transitions:(1980BA54, 1980RI06, 1981KO1Q, 1983AD1B, 1984MA2J). Astrophysical questions: (1980BA1P, 1983LI01, 1985GI1C). Applied work: (1982BO1N, 1982HA1V, 1982HI1H, 1982MA1T, 1982PI1H, 1982YA1C, 1983HA1W, 1983KO1Q, 1984HI1D, 1984MO1Q, 1984MO1R, 1984NI1C). Complex

  4. A=14Be (1986AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    86AJ01) (See the Isobar Diagram for 14Be) 14Be has been observed in the 4.8 GeV proton bombardment of uranium [see (1976AJ04)], in the bombardment of 232Th by 145 MeV 15N ions (1982OG02; forward differential cross section is 4 × 10-5 mb/sr) and in the 14C(π-, π+)14Be reaction (1984GI09; Eπ- = 164 MeV, θ = 5° It has not been observed in the 48Ca(14C, 14Be)48Ti reaction (E(14C) = 87.4 MeV, θ = 4° - 8° (1981NA1H). A group in the (π-, π+) reaction is observed at Q = -37.08 ± 0.13 MeV

  5. A=14N (1981AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    81AJ01) (See Energy Level Diagrams for 14N) GENERAL: See also (1976AJ04) and Table 14.10 [Table of Energy Levels] (in PDF or PS). Model calculations: (1976CO1R, 1978FU13). Special states: (1977GO1H, 1977RI08, 1979KI10). Electromagnetic transitions: (1977DO06, 1977KO1N, 1977YO1D, 1978FU13, 1978KI08). Giant resonances: (1979DO17, 1979KI11). Astrophysical questions: (1976AU1B, 1976BO1M, 1976DI1F, 1976DW1A, 1976EP1A, 1976FI1E, 1976GI1C, 1976ME1H, 1976NO1C, 1976OS1E, 1976QU1A, 1976RO1J, 1976SI1D,

  6. A=15O (1986AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6AJ01) (See Energy Level Diagrams for 15O) GENERAL: See also (1981AJ01) and Table 15.17 [Table of Energy Levels] (in PDF or PS) here. Nuclear models:(1982WA1Q, 1982YA1D, 1983SH38). Special states:(1979GO27, 1980GO1Q, 1980HI1C, 1984ST1E). Electromagentic transitions:(1980KO1L, 1980MI1G, 1980RI06, 1982AW02, 1983TO08, 1984CA02). Astrophysical questions:(1980BA1P, 1981WA1Q, 1983LI01, 1985GI1C). Complex reactions involving 15O:(1981HU1D, 1981SC1P, 1983DE26, 1983FR1A, 1983JA05, 1983OL1A, 1983WI1A,

  7. NERSC Climate PIs Telecon!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Systems Update NERSC Systems Early 2015 2 x 10 Gb 1 x 100 Gb So#ware D efined N etworking Data---Intensive S ystems Carver, P DSF, J GI,KBASE,HEP 1 4x Q DR Vis & A naly3cs D ata T ransfer N odes Adv. A rch. Testbeds S cience G ateways Global Scratch 3.6 PB 5 x S FA12KE /project 5 PB DDN9900 & NexSAN /home 250 TB NetApp 5 460 50 P B s tored, 2 40 PB c apacity, 2 0 years o f community d ata HPSS 80 GB/s 50 GB/s 5 GB/s 12 GB/s 16 x Q DR I B 2.2 PB Local Scratch 70 G B/s Hopper: 1

  8. Research News TEMPLATE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Revealing Secrets Locked in the Ice page 3 the ENERGY lab NATIONAL ENERGY TECHNOLOGY LABORATORY From NETL's Office of Research & Development - October 2014, Issue 1 Researchnews Science & Engineering To Power Our Future 2 FE AT U RE ST O RY : R e v e a li n g S e c re ts L o c k e d in th e Ic e pa ge 3 Fr om NE TL 's O ffi ce of Re se ar ch & De ve lo pm en t - O ct ob er 20 14 , Iss ue 1 R e s e a r c h n e w s Sc ien ce & En gi ne er in g To Po we r Ou r Fu tu re Contents

  9. Lisa Gerhardt! NERSC User Services Group! NUG Training!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February 23, 2015 Data Management at NERSC Where Do I Put My Data? --- 2 --- * Overview o f N ERSC fi le s ystems - Local v s. G lobal - Permanent v s. P urged - Personal v s. S hared * HPSS A rchive S ystem - What i s i t a nd h ow t o u se i t * Data S haring NERSC File Systems --- 3 --- The compute and storage systems 2015 Produc=on C lusters Carver, P DSF, J GI, MatComp, Planck /global/ scratch 4 PB /project 5 PB /home 250 TB 70 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata

  10. Jason Hick! Storage Systems Group NERSC User Group Storage Update

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC User Group Storage Update Feb 2 6, 2 014 The compute and storage systems 2014 Sponsored C ompute S ystems Carver, P DSF, J GI, K BASE, H EP 8 x F DR I B /global/ scratch 4 PB /project 5 PB /home 250 TB 45 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata HPSS 48 GB/s 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 80 GB/s Ethernet & I B F abric Science F riendly S ecurity ProducKon M onitoring Power E fficiency WAN 2 x 10 Gb 1 x 100 Gb Science D ata N etwork

  11. Jason Hick! Storage Systems Group! NERSC User Group Meeting!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Group! ! NERSC User Group Meeting! February 6, 2014 Storage Systems: 2014 and beyond The compute and storage systems 2013 Produc(on C lusters Carver, P DSF, J GI,KBASE,HEP 1 4x Q DR Global Scratch 3.6 PB 5 x S FA12KE /project 5 PB DDN9900 & NexSAN /home 250 TB NetApp 5 460 50 P B s tored, 2 40 PB c apacity, 3 5 years o f community d ata HPSS 16 x Q DR I B 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 16 x F DR I B Ethernet & I B F abric Science F riendly S ecurity

  12. Jay Srinivasan! Group Lead, Computational Systems!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Group Lead, Computational Systems! NUG - Feb 2015 Computational Systems Update NERSC - 2014 --- 2 --- Sponsored C ompute S ystems Carver, P DSF, J GI, K BASE, H EP 8 x F DR I B /global/ scratch 4 PB /project 5 PB /home 250 TB 45 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata HPSS 48 GB/s 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 80 GB/s 2 x 10 Gb 1 x 100 Gb Science D ata N etwork Vis & A naly?cs, D ata T ransfer N odes, Adv. A rch., S cience G ateways 80

  13. A=18F (1972AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2AJ02) (See Energy Level Diagrams for 18F) GENERAL: See also (1959AJ76) and Table 18.10 [Table of Energy Levels] (in PDF or PS). Shell model: (1957WI1E, 1959BR1E, 1960TA1C, 1961TR1B, 1962TA1D, 1964FE02, 1964IN03, 1964PA1D, 1964YO1B, 1965BA1J, 1965DE1H, 1965GI1B, 1966BA2E, 1966BA2C, 1966HU09, 1966IN01, 1966KU05, 1966RI1F, 1967EN01, 1967EV1C, 1967FE01, 1967FL01, 1967HO11, 1967IN03, 1967KU09, 1967KU13, 1967LY02, 1967MO1J, 1967PA1K, 1967PI1B, 1967VI1B, 1967WO1C, 1968AR02, 1968BE1T, 1968BH1B,

  14. A=20C (1987AJ02)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7AJ02) (Not illustrated) 20C has been observed in the fragmentation of 60 MeV/A argon ions: its mass excess is 37.20 ± 1.13 MeV (1987GI1E). It is then stable with respect to 19C + n and 18C + 2n by 3.3 and 3.9 MeV, respectively. See also (1978AJ03, 1983AJ01). The half-life of 20C is calculated to be 9.3 × 10-3 sec (1984KL06). See also (1985AN1B, 1985LA03, 1986AN07, 1986GU1D) and (1982AV1A, 1983ANZQ, 1987SA15

  15. A=20Ne (1978AJ03)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8AJ03) (See Energy Level Diagrams for 20Ne) GENERAL: See also (1972AJ02) and Table 20.18 [Table of Energy Levels] (in PDF or PS). Shell model: (1970CR1A, 1971DE56, 1971RA1B, 1971ZO1A, 1972AB12, 1972AR1F, 1972AS13, 1972BO38, 1972BR1G, 1972JA24, 1972KA39, 1972KA67, 1972KH08, 1972KR1D, 1972KU1F, 1972LE13, 1972LE38, 1972MA07, 1972NI14, 1972RE03, 1972SA1B, 1972VO09, 1972WH04, 1973CO03, 1973DH1A, 1973EL04, 1973EN1C, 1973GI09, 1973HA05, 1973HE1F, 1973IC01, 1973IR01, 1973MA1K, 1973MC06, 1973MC1E,

  16. A=5Li (1984AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    84AJ01) (See Energy Level Diagrams for 5Li) GENERAL: See also (1979AJ01) and Table 5.3 [Table of Energy Levels] (in PDF or PS) here. Model calculations:(1978RE1A, 1979MA1J, 1980HA1M, 1981BE10, 1982FI13). Special states:(1981BE10, 1981KU1H, 1982EM1A, 1982FI13, 1982FR1D). Complex reactions involving 5Li:(1979BR02, 1979RU1B). Reactions involving pions:(1978BR1V, 1979SA1W, 1983AS02). Reactions involving antiprotons:(1981YA1B). Hypernuclei:(1980IW1A, 1981KO1V, 1981KU1H, 1983GI1C). Other

  17. A=7Be (1979AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9AJ01) (See Energy Level Diagrams for 7Be) GENERAL: See also (1974AJ01) and Table 7.6 [Table of Energy Levels] (in PDF or PS). Nuclear models: (1974KA11). Astrophysical question: (1973BA1H, 1973IB1A, 1973SM1A, 1973TR1C, 1973WE1D, 1974KO1C, 1974PA10, 1974RA09, 1974SH1D, 1975HO1C, 1975KI14, 1975SC1H, 1976BE1C, 1976BO1E, 1976CL1A, 1976CO1B, 1976FU1B, 1976GI1C, 1976HE15, 1976PE1A, 1976RA1C, 1976SI1C, 1976VI1A, 1977AU1B, 1977BA1V, 1977BI1E, 1977GA1C, 1977HA1L, 1977KO1J, 1977MO1E, 1977SC1D, 1977SI1D,

  18. A=7He (1988AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8AJ01) (See the Isobar Diagram for 7He) GENERAL: See also (1984AJ01) and Table 7.1 [Table of Energy Levels] (in PDF or PS). Hypernuclei: (1982KA1D, 1983FE07, 1984AS1D, 1985KO1G, 1986DA1B, 1986DO01, 1986ME1F). Other topics: (1983ANZQ, 1984FR13, 1984VA06, 1986GI10, 1986SH1L, 1987BO40, 1987GOZN, 1987PE1C). Mass of 7He: The atomic mass excess of 7He is 26.11 ± 0.03 MeV: 7He is then unbound with respect to decay into 6He + n by 0.44 MeV: see (1984AJ01). The ground state is calculated to have Jπ =

  19. A=9He (1974AJ01)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4AJ01) (Not illustrated) 9He is predicted to be particle unstable: its calculated mass excess > 40.17 MeV (1970WA1G, 1972WA07), = 43.54 MeV (1972TH13). Particle instability with respect to 8He + n, 7He + 2n and 6He + 3n implies atomic mass excesses greater than 39.7, 42.25 and 41.812 MeV, respectively. See also (1968CE1A). 9He has not been observed in a pion experiment [9Be(π-, π+)9He] (1965GI10) nor in the spontaneous fission of 252Cf (1967CO1K

  20. C:\Forms\HQ F 1410.4.cdr

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    F-1410.4 (11-79) 2 . SENT F ROM ( NAME OF OFFI CE) 5. RECEI VED BY ( NAME OR OFFI CE) Thank you for your cooperation. Please return promptly. SECTI ON A ( O P T I O N A L F O L D ) ( O P T I O N A L F O L D ) 3 . DAT E 6 . DAT E ORI GI NAT I NG OF F I CE USE 8 . DAT E DI SPAT CHED FOR RETURN 4 . T I ME 7 . T I ME T I ME RETURNED - - DAT E 9 . T I ME A M A M A M A M P M P M P M P M 1 . CONTROL NO. TO: RETURN TO: ORIGINATOR FILL IN: ORIGINATOR FILL IN: RECIPIENT FILL IN: U.S. DEPARTMENT OF ENERGY

  1. Optimization of leaf margins for lung stereotactic body radiotherapy using a flattening filter-free beam

    SciTech Connect (OSTI)

    Wakai, Nobuhide; Sumida, Iori; Otani, Yuki; Suzuki, Osamu; Seo, Yuji; Isohashi, Fumiaki; Yoshioka, Yasuo; Ogawa, Kazuhiko; Hasegawa, Masatoshi

    2015-05-15

    Purpose: The authors sought to determine the optimal collimator leaf margins which minimize normal tissue dose while achieving high conformity and to evaluate differences between the use of a flattening filter-free (FFF) beam and a flattening-filtered (FF) beam. Methods: Sixteen lung cancer patients scheduled for stereotactic body radiotherapy underwent treatment planning for a 7 MV FFF and a 6 MV FF beams to the planning target volume (PTV) with a range of leaf margins (?3 to 3 mm). Forty grays per four fractions were prescribed as a PTV D95. For PTV, the heterogeneity index (HI), conformity index, modified gradient index (GI), defined as the 50% isodose volume divided by target volume, maximum dose (Dmax), and mean dose (Dmean) were calculated. Mean lung dose (MLD), V20 Gy, and V5 Gy for the lung (defined as the volumes of lung receiving at least 20 and 5 Gy), mean heart dose, and Dmax to the spinal cord were measured as doses to organs at risk (OARs). Paired t-tests were used for statistical analysis. Results: HI was inversely related to changes in leaf margin. Conformity index and modified GI initially decreased as leaf margin width increased. After reaching a minimum, the two values then increased as leaf margin increased (V shape). The optimal leaf margins for conformity index and modified GI were ?1.1 0.3 mm (mean 1 SD) and ?0.2 0.9 mm, respectively, for 7 MV FFF compared to ?1.0 0.4 and ?0.3 0.9 mm, respectively, for 6 MV FF. Dmax and Dmean for 7 MV FFF were higher than those for 6 MV FF by 3.6% and 1.7%, respectively. There was a positive correlation between the ratios of HI, Dmax, and Dmean for 7 MV FFF to those for 6 MV FF and PTV size (R = 0.767, 0.809, and 0.643, respectively). The differences in MLD, V20 Gy, and V5 Gy for lung between FFF and FF beams were negligible. The optimal leaf margins for MLD, V20 Gy, and V5 Gy for lung were ?0.9 0.6, ?1.1 0.8, and ?2.1 1.2 mm, respectively, for 7 MV FFF compared to ?0.9 0.6, ?1.1 0

  2. S U M M A R I E S U.S. Energy Information Administration | State Energy Data 2014: Prices and Expenditures

    Gasoline and Diesel Fuel Update (EIA)

    Prices and Expenditures 10 Table E8. Primary Energy, Electricity, and Total Energy Expenditure Estimates, 2014 (Million Dollars) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass Total g,h,i Distillate Fuel Oil Jet Fuel b LPG c Motor Gasoline d Residual Fuel Oil Other e Total Wood and Waste f Alabama 1,677.3 3,521.2 3,718.3 283.1 226.6 8,039.9 97.2 713.3 13,078.4 344.2 498.0 19,119.2 -3,336.0 8,363.3 24,146.5

  3. S U M M A R I E S U.S. Energy Information Administration | State Energy Data 2014: Prices and Expenditures

    Gasoline and Diesel Fuel Update (EIA)

    3 Table E1. Primary Energy, Electricity, and Total Energy Price Estimates, 2014 (Dollars per Million Btu) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass Total g,h,i Distillate Fuel Oil Jet Fuel b LPG c Motor Gasoline d Residual Fuel Oil Other e Total Wood and Waste f Alabama 2.91 5.81 25.88 19.92 26.79 25.88 12.59 28.08 25.64 0.80 3.43 8.43 2.60 27.20 18.64 Alaska 4.87 6.99 28.53 20.97 27.65 33.67 18.87 19.35

  4. In situ quantification of genomic instability in breast cancer progression

    SciTech Connect (OSTI)

    Ortiz de Solorzano, Carlos; Chin, Koei; Gray, Joe W.; Lockett, Stephen J.

    2003-05-15

    Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal breast epithelium, preneoplastic lesions (usual ductal hyperplasia), ductal carcinona is situ or invasive carcinoma of the breast. Our in situ-cell by cell-analysis of genomic instability shows an important increase of genomic instability in the transition from hyperplasia to in situ carcinoma, followed by a reduction of instability in invasive carcinoma. This pattern suggests that the transition from hyperplasia to in situ carcinoma corresponds to telomere crisis and invasive carcinoma is a consequence of telomerase reactivation afertelomere crisis.

  5. The SDSS view of the Palomar-Green bright quasar survey

    SciTech Connect (OSTI)

    Jester, Sebastian; Schneider, Donald P.; Richards, Gordon T.; Green, Richard F.; Schmidt, Maarten; Hall, Patrick B.; Strauss, Michael A.; Vanden Berk, Daniel E.; Stoughton, Chris; Gunn, James E.; Brinkmann, Jon; Kent, Stephen M.; Smith, J.Allyn; Tucker, Douglas, L.; Yanny, Brian; /Fermilab /Penn State U., Astron. Astrophys. /Princeton U. Observ. /Kitt Peak Observ. /Caltech /Chicago U., Astron. Astrophys. Ctr. /York U., Canada /Apache Point Observ. /Wyoming U. /Los Alamos

    2005-02-01

    The author investigates the extent to which the Palomar-Green (PG) Bright Quasar Survey (BQS) is complete and representative of the general quasar population by comparing with imaging and spectroscopy from the Sloan Digital Sky Survey. A comparison of SDSS and PG photometry of both stars and quasars reveals the need to apply a color and magnitude recalibration to the PG data. Using the SDSS photometric catalog, they define the PG's parent sample of objects that are not main-sequence stars and simulate the selection of objects from this parent sample using the PG photometric criteria and errors. This simulation shows that the effective U-B cut in the PG survey is U-B < -0.71, implying a color-related incompleteness. As the color distribution of bright quasars peaks near U-B = -0.7 and the 2-{sigma} error in U-B is comparable to the full width of the color distribution of quasars, the color incompleteness of the BQS is approximately 50% and essentially random with respect to U-B color for z < 0.5. There is however, a bias against bright quasars at 0.5 < z < 1, which is induced by the color-redshift relation of quasars (although quasars at z > 0.5 are inherently rare in bright surveys in any case). They find no evidence for any other systematic incompleteness when comparing the distributions in color, redshift, and FIRST radio properties of the BQS and a BQS-like subsample of the SDSS quasar sample. However, the application of a bright magnitude limit biases the BQS toward the inclusion of objects which are blue in g-i, in particular compared to the full range of g-i colors found among the i-band limited SDSS quasars, and even at i-band magnitudes comparable to those of the BQS objects.

  6. Experimental single-strain mobilomics reveals events that shape pathogen emergence

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Schoeniger, Joseph S.; Hudson, Corey M.; Bent, Zachary W.; Sinha, Anupama; Williams, Kelly P.

    2016-07-04

    Virulence and resistance genes carried on mobile DNAs such as genomic islands (GIs) and plasmids promote bacterial pathogen emergence. An early step in the mobilization of GIs is their excision, which produces both a circular form of the GI and a deletion site in the chromosome; circular forms have also been described for some bacterial insertion sequences (ISs). We demonstrate that the recombinant sequence produced at the junction of such circles, and their corresponding deletion sites, can be detected sensitively in high throughput sequencing data, using new computational methods that enable empirical discovery of new mobile DNAs. Applied to themore » rich mobilome of a single strain (Kpn2146) of the emerging multidrug-resistant pathogen Klebsiella pneumoniae, our approach detected circular junctions for six GIs and seven IS types (several of the latter not previously known to circularize). Our methods further revealed differential biology of multiple mobile DNAs, imprecision of integrases and transposases, and differential activity among identical IS copies for IS26, ISKpn18 and ISKpn21. Exonuclease was used to enrich for circular dsDNA molecules, and internal calibration with the native Kpn2146 plasmids showed that not all molecules bearing GI and IS circular junctions were circular dsDNAs. Transposition events were also detected, revealing replicon preference (ISKpn18 preferring a conjugative IncA/C2 plasmid), local action (IS26), regional preferences, selection (against capsule synthesis), and left-right IS end swapping. Efficient discovery and global characterization of numerous mobile elements per experiment will allow detailed accounting of bacterial evolution, explaining the new gene combinations that arise in emerging pathogens.« less

  7. MIGRATION OF GAS GIANT PLANETS IN GRAVITATIONALLY UNSTABLE DISKS

    SciTech Connect (OSTI)

    Michael, Scott; Durisen, Richard H.; Boley, Aaron C. E-mail: durisen@astro.indiana.edu

    2011-08-20

    Characterization of migration in gravitationally unstable disks is necessary to understand the fate of protoplanets formed by disk instability. As part of a larger study, we are using a three-dimensional radiative hydrodynamics code to investigate how an embedded gas giant planet interacts with a gas disk that undergoes gravitational instabilities (GIs). This Letter presents results from simulations with a Jupiter-mass planet placed in orbit at 25 AU within a 0.14 M{sub sun} disk. The disk spans 5-40 AU around a 1 M{sub sun} star and is initially marginally unstable. In one simulation, the planet is inserted prior to the eruption of GIs; in another, it is inserted only after the disk has settled into a quasi-steady GI-active state, where heating by GIs roughly balances radiative cooling. When the planet is present from the beginning, its own wake stimulates growth of a particular global mode with which it strongly interacts, and the planet plunges inward 6 AU in about 10{sup 3} years. In both cases with embedded planets, there are times when the planet's radial motion is slow and varies in direction. At other times, when the planet appears to be interacting with strong spiral modes, migration both inward and outward can be relatively rapid, covering several AUs over hundreds of years. Migration in both cases appears to stall near the inner Lindblad resonance of a dominant low-order mode. Planet orbit eccentricities fluctuate rapidly between about 0.02 and 0.1 throughout the GI-active phases of the simulations.

  8. Acute Toxicity After Image-Guided Intensity Modulated Radiation Therapy Compared to 3D Conformal Radiation Therapy in Prostate Cancer Patients

    SciTech Connect (OSTI)

    Wortel, Ruud C.; Incrocci, Luca; Pos, Floris J.; Lebesque, Joos V.; Witte, Marnix G.; Heide, Uulke A. van der; Herk, Marcel van; Heemsbergen, Wilma D.

    2015-03-15

    Purpose: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. Methods and Materials: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. Results: The median volumes receiving 5 to 75 Gy were significantly lower (all P<.001) with IG-IMRT for anorectum, anal canal, and bladder. The mean dose to the anorectum was 34.4 Gy versus 47.3 Gy (P<.001), 23.6 Gy versus 44.6 Gy for the anal canal (P<.001), and 33.1 Gy versus 43.2 Gy for the bladder (P<.001). Significantly lower grade ≥2 toxicity was observed for proctitis, stool frequency ≥6/day, and urinary frequency ≥12/day. IG-IMRT resulted in significantly lower overall RTOG grade ≥2 GI toxicity (29% vs 49%, respectively, P=.002) and overall GU grade ≥2 toxicity (38% vs 48%, respectively, P=.009). Conclusions: A clinically meaningful reduction in dose to organs at risk and acute toxicity levels was observed in IG-IMRT patients, as a result of improved technique and tighter margins. Therefore reduced late toxicity levels can be expected as well; additional research is needed to quantify such reductions.

  9. Long-Term Efficacy and Toxicity of Low-Dose-Rate {sup 125}I Prostate Brachytherapy as Monotherapy in Low-, Intermediate-, and High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Kittel, Jeffrey A.; Reddy, Chandana A.; Smith, Kristin L.; Stephans, Kevin L.; Tendulkar, Rahul D.; Ulchaker, James; Angermeier, Kenneth; Campbell, Steven; Stephenson, Andrew; Klein, Eric A.; Wilkinson, D. Allan; Ciezki, Jay P.

    2015-07-15

    Purpose/Objectives: To report long-term efficacy and toxicity for a single-institution cohort of patients treated with low-dose-rate prostate brachytherapy permanent implant (PI) monotherapy. Methods and Materials: From 1996 to 2007, 1989 patients with low-risk (61.3%), intermediate-risk (29.8%), high-intermediate-risk (4.5%), and high-risk prostate cancer (4.4%) were treated with PI and followed up prospectively in a registry. All patients were treated with {sup 125}I monotherapy to 144 Gy. Late toxicity was coded retrospectively according to a modified Common Terminology Criteria for Adverse Events 4.0 scale. The rates of biochemical relapse-free survival (bRFS), distant metastasis-free survival (DMFS), overall survival (OS), and prostate cancer–specific mortality (PCSM) were calculated. We identified factors associated with late grade ≥3 genitourinary (GU) and gastrointestinal (GI) toxicity, bRFS, DMFS, OS, PCSM, and incontinence. Results: The median age of the patients was 67 years, and the median overall and prostate-specific antigen follow-up times were 6.8 years and 5.8 years, respectively. The overall 5-year rates for bRFS, DMFS, OS, and PCSM were 91.9%, 97.8%, 93.7%, and 0.71%, respectively. The 10-year rates were 81.5%, 91.5%, 76.1%, and 2.5%, respectively. The overall rates of late grade ≥3 GU and GI toxicity were 7.6% and 0.8%, respectively. On multivariable analysis, age and prostate length were significantly associated with increased risk of late grade ≥3 GU toxicity. The risk of incontinence was highly correlated with both pre-PI and post-PI transurethral resection of the prostate. Conclusions: Prostate brachytherapy as monotherapy is an effective treatment for low-risk and low-intermediate-risk prostate cancer and appears promising as a treatment for high-intermediate-risk and high-risk prostate cancer. Significant long-term toxicities are rare when brachytherapy is performed as monotherapy.

  10. SU-E-T-548: How To Decrease Spine Dose In Patients Who Underwent Sterotactic Spine Radiosurgery?

    SciTech Connect (OSTI)

    Acar, H; Altinok, A; Kucukmorkoc, E; Kucuk, N; Caglar, H

    2014-06-01

    Purpose: Stereotactic radiosurgery for spine metastases involves irradiation using a single high dose fraction. The purpose of this study was to dosimetrically compare stereotactic spine radiosurgery(SRS) plans using a recently new volumetric modulated arc therapy(VMAT) technique against fix-field intensity-modulated radiotherapy(IMRT). Plans were evaluated for target conformity and spinal cord sparing. Methods: Fifteen previously treated patients were replanned using the Eclipse 10.1 TPS AAA calculation algorithm. IMRT plans with 7 fields were generated. The arc plans used 2 full arc configurations. Arc and IMRT plans were normalized and prescribed to deliver 16.0 Gy in a single fraction to 90% of the planning target volume(PTV). PTVs consisted of the vertebral body expanded by 3mm, excluding the PRV-cord, where the cord was expanded by 2mm.RTOG 0631 recommendations were applied for treatment planning. Partial spinal cord volume was defined as 5mm above and below the radiosurgery target volume. Plans were compared for conformity and gradient index as well as spinal cord sparing. Results: The conformity index values of fifteen patients for two different treatment planning techniques were shown in table 1. Conformity index values for 2 full arc planning (average CI=0.84) were higher than that of IMRT planning (average CI=0.79). The gradient index values of fifteen patients for two different treatment planning techniques were shown in table 2. Gradient index values for 2 full arc planning (average GI=3.58) were higher than that of IMRT planning (average GI=2.82).The spinal cord doses of fifteen patients for two different treatment planning techniques were shown in table 3. D0.35cc, D0.03cc and partial spinal cord D10% values in 2 full arc plannings (average D0.35cc=819.3cGy, D0.03cc=965.4cGy, 10%partial spinal=718.1cGy) were lower than IMRT plannings (average D0.35cc=877.4cGy, D0.03c=1071.4cGy, 10%partial spinal=805.1cGy). Conclusions: The two arc VMAT technique is

  11. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    SciTech Connect (OSTI)

    MALAFEEW, VAL

    2012-12-12

    Version 14 NRCDose is a user-friendly 32-bit PC-based software interface for the LADTAP II, GASPAR II, and XOQDOQ programs which operates under all Microsoft WindowsTM platforms. LADTAP II, GASPAR II, and XOQDOQ are industry standards, originally created for mainframe computers and written using the Fortran programming language. While still utilizing the proven Fortran code modules, NRCDose allows the user to enter and retrieve data through a series of windows dialogs, making the use of the program much more user-friendly and efficient than its original design. This graphical interface also allows the user to create sets of data that can be named and retrieved at a later date for review or modification. The NRCDose program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The source of the DCFs (dose conversion factors) in NRCDose is Regulatory Guide 1.109, supplemented with additional dose factors from NUREG-0172. See Abstract for recent modifications.

  12. THE SLUGGS SURVEY: NGC 3115, A CRITICAL TEST CASE FOR METALLICITY BIMODALITY IN GLOBULAR CLUSTER SYSTEMS

    SciTech Connect (OSTI)

    Brodie, Jean P.; Conroy, Charlie; Arnold, Jacob A.; Romanowsky, Aaron J.; Usher, Christopher; Forbes, Duncan A.; Strader, Jay

    2012-11-10

    Due to its proximity (9 Mpc) and the strongly bimodal color distribution of its spectroscopically well-sampled globular cluster (GC) system, the early-type galaxy NGC 3115 provides one of the best available tests of whether the color bimodality widely observed in GC systems generally reflects a true metallicity bimodality. Color bimodality has alternatively been attributed to a strongly nonlinear color-metallicity relation reflecting the influence of hot horizontal-branch stars. Here, we couple Subaru Suprime-Cam gi photometry with Keck/DEIMOS spectroscopy to accurately measure GC colors and a CaT index that measures the Ca II triplet. We find the NGC 3115 GC system to be unambiguously bimodal in both color and the CaT index. Using simple stellar population models, we show that the CaT index is essentially unaffected by variations in horizontal-branch morphology over the range of metallicities relevant to GC systems (and is thus a robust indicator of metallicity) and confirm bimodality in the metallicity distribution. We assess the existing evidence for and against multiple metallicity subpopulations in early- and late-type galaxies and conclude that metallicity bi/multimodality is common. We briefly discuss how this fundamental characteristic links directly to the star formation and assembly histories of galaxies.

  13. Defect sink characteristics of specific grain boundary types in 304 stainless steels under high dose neutron environments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Field, Kevin G.; Yang, Ying; Busby, Jeremy T.; Allen, Todd R.

    2015-03-09

    Radiation induced segregation (RIS) is a well-studied phenomena which occurs in many structurally relevant nuclear materials including austenitic stainless steels. RIS occurs due to solute atoms preferentially coupling to mobile point defect fluxes that migrate and interact with defect sinks. Here, a 304 stainless steel was neutron irradiated up to 47.1 dpa at 320 °C. Investigations into the RIS response at specific grain boundary types were utilized to determine the sink characteristics of different boundary types as a function of irradiation dose. A rate theory model built on the foundation of the modified inverse Kirkendall (MIK) model is proposed andmore » benchmarked to the experimental results. This model, termed the GiMIK model, includes alterations in the boundary conditions based on grain boundary structure and includes expressions for interstitial binding. This investigation, through experiment and modeling, found specific grain boundary structures exhibit unique defect sink characteristics depending on their local structure. Furthermore, such interactions were found to be consistent across all doses investigated and had larger global implications including precipitation of Ni-Si clusters near different grain boundary types.« less

  14. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    Energy Science and Technology Software Center (OSTI)

    2012-12-12

    Version 14 NRCDose is a user-friendly 32-bit PC-based software interface for the LADTAP II, GASPAR II, and XOQDOQ programs which operates under all Microsoft WindowsTM platforms. LADTAP II, GASPAR II, and XOQDOQ are industry standards, originally created for mainframe computers and written using the Fortran programming language. While still utilizing the proven Fortran code modules, NRCDose allows the user to enter and retrieve data through a series of windows dialogs, making the use of themore » program much more user-friendly and efficient than its original design. This graphical interface also allows the user to create sets of data that can be named and retrieved at a later date for review or modification. The NRCDose program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The source of the DCFs (dose conversion factors) in NRCDose is Regulatory Guide 1.109, supplemented with additional dose factors from NUREG-0172. See Abstract for recent modifications.« less

  15. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    Energy Science and Technology Software Center (OSTI)

    2012-12-13

    Version 03 NRCDose72 is a software program developed by Chesapeake Nuclear Services that integrates the NRC’s Fortran programs LADTAP II, GASPAR II, and XOQDOQ and provides a user-friendly interface for running the codes on a PC. These codes provide an accepted regulatory basis for assessing doses to the public as required for the licensing assessments for both license renewal and new build nuclear plants. Chesapeake Nuclear Services undertook an effort to update the dose conversionmore » factors (DCFs) used in NRCDose72 to the factors reported in ICRP-72, naming the new program NRCDose72. The original NRCDose72 program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The ICRP-72 methodology contains additional parameters, including dose factors for 25 discrete organs, plus a remainder organ and effective DCF. Also, there are a total of six different age ranges (newborn, 1‑yr. old, 5-yr. old, 10-yr. old, 15-yr. old, and adult). Finally, ICRP-72 contains DCFs for a variety of chemical forms (H-3 as vapor or Organically Bound Tritium, for example) or inhalation classes (F, M or S for nearly all radionuclides). See Abstract for recent modifications.« less

  16. Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

    SciTech Connect (OSTI)

    Kapoor, Neeraj; Menon, Santosh T.; Chauhan, Radha; Sachdev, Pallavi; Sakmar, Thomas P.

    2010-01-12

    Heptahelical G-protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors couple to heterotrimeric G proteins to relay extracellular signals to intracellular signaling networks, but the molecular mechanism underlying guanosine 5'-diphosphate (GDP) release by the G protein {alpha}-subunit is not well understood. Amino acid substitutions in the conserved {alpha}5 helix of Gi, which extends from the C-terminal region to the nucleotide-binding pocket, cause dramatic increases in basal (receptor-independent) GDP release rates. For example, mutant G{alpha}{sub i1}-T329A shows an 18-fold increase in basal GDP release rate and, when expressed in culture, it causes a significant decrease in forskolin-stimulated cAMP accumulation. The crystal structure of G{alpha}{sub i1}-T329A {center_dot} GDP shows substantial conformational rearrangement of the switch I region and additional striking alterations of side chains lining the catalytic pocket that disrupt the Mg{sup +2} coordination sphere and dislodge bound Mg{sup +2}. We propose a 'sequential release' mechanism whereby a transient conformational change in the {alpha}5 helix alters switch I to induce GDP release. Interestingly, this mechanistic model for heterotrimeric G protein activation is similar to that suggested for the activation of the plant small G protein Rop4 by RopGEF8.

  17. Energies and E1, M1, E2, and M2 transition rates for states of the 2s{sup 2}2p{sup 3}, 2s2p{sup 4}, and 2p{sup 5} configurations in nitrogen-like ions between F III and Kr XXX

    SciTech Connect (OSTI)

    Rynkun, P.; Jönsson, P.; Gaigalas, G.; Froese Fischer, C.

    2014-03-15

    Based on relativistic wavefunctions from multiconfiguration Dirac–Hartree–Fock and configuration interaction calculations, E1, M1, E2, and M2 transition rates, weighted oscillator strengths, and lifetimes are evaluated for the states of the (1s{sup 2})2s{sup 2}2p{sup 3},2s2p{sup 4}, and 2p{sup 5} configurations in all nitrogen-like ions between F III and Kr XXX. The wavefunction expansions include valence, core–valence, and core–core correlation effects through single–double multireference expansions to increasing sets of active orbitals. The computed energies agree very well with experimental values, with differences of only 300–600 cm{sup −1} for the majority of the levels and ions in the sequence. Computed transitions rates are in close agreement with available data from MCHF-BP calculations by Tachiev and Froese Fischer [G.I. Tachiev, C. Froese Fischer, A and A 385 (2002) 716].

  18. Opto-Electronic Characterization CdTe Solar Cells from TCO to Back Contact with Nano-Scale CL Probe

    SciTech Connect (OSTI)

    Moseley, John; Al-Jassim, Mowafak M.; Paudel, Naba; Mahabaduge, Hasitha; Kuciauskas, Darius; Guthrey, Harvey L.; Duenow, Joel; Yan, Yanfa; Metzger, Wyatt K.; Ahrenkiel, Richard K.

    2015-06-14

    We used cathodoluminescence (CL) (spectrum-per-pixel) imaging on beveled CdTe solar cell sections to investigate the opto-electronic properties of these devices from the TCO to the back contact. We used a nano-scale CL probe to resolve luminescence from grain boundary (GB) and grain interior (GI) locations near the CdS/CdTe interface where the grains are very small. As-deposited, CdCl2-treated, Cu-treated, and (CdCl2+Cu)-treated cells were analyzed. Color-coded CL spectrum imaging maps on bevels illustrate the distribution of the T=6 K luminescence transitions through the depth of devices with unprecedented spatial resolution. The CL at the GBs and GIs is shown to vary significantly from the front to the back of devices and is a sensitive function of processing. Supporting D-SIMS depth profile, TRPL lifetime, and C-V measurements are used to link the CL data to the J-V performance of devices.

  19. Handbook of synfuels technology

    SciTech Connect (OSTI)

    Meyers, R.A.

    1984-01-01

    This book explores various methods of producing synthetic fuels. Topics considered include coal liquefaction, Exxon Donor Solvent Coal Liquefaction Process, the H-Coal Process, the SRC-I Coal Liquefaction Process, the coal hydrogenation plant at Bottrop, production of liquid fuels from coal-derived synthesis gas, the Sasol plant, the ICI low pressure methanol process, Mobil Methanol-to-Gasoline (MTG) Process, the Lurgi low pressure methanol process, coal gasification the Texaco Coal Gasification Process, the Shell Coal Gasification Process, the Combustion Engineering Coal Gasification Process, British Gas/Lurgi Slagging Gasifier, KBW Coal Gasification, fluidized-bed coal gasification process (type Winkler), Lurgi coal gasification (dry bottom gasifier), Foster Wheeler Stoic Process, the WD-GI two stage coal gasifier, the Saarberg/Otto Coal Gasification Process, Allis-Chalmers KILnGAS Process, the purification of gases derived from coal, shale oil, Lurgi-Ruhrgas Process, the Tosco II Process, Paraho oil shale retorting processes, Occidental Modified In-Situ (MIS) Process, the geokinetics in-situ retorting process, oil shale pre-beneficiation, additional oil shale technologies, oil from oil sand, Suncor Hot Water Process, emerging technologies for oil from oil sands, synfuels upgrading and refining, Exxon fluid coking/flexicoking processes for synfuels upgrading applications, H-Oil processes, LC-Fining Process, and The Modified Litol Process for benzene production.

  20. Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hu, M; Wang, Xiliang

    2014-12-05

    Melanoma is a malignant tumor of melanocytes with high capability of invasion and rapid metastasis to other organs. Malignant melanoma is the most common metastatic malignancy found in gastrointestinal tract (GI). To the best of our knowledge, previous studies of melanoma in gastrointestinal tract are all clinical case reports. In this work, 1H NMR-based metabolomics approach is used to investigate the metabolite profiles differences of stomach tissue extracts of metastatic B16-F10 melanoma in C57BL/6J mouse and search for specific metabolite biomarker candidates. Principal Component Analysis (PCA), an unsupervised multivariate data analysis method, is used to detect possible outliers, while Orthogonalmore » Projection to Latent Structure (OPLS), a supervised multivariate data analysis method, is employed to evaluate important metabolites responsible for discriminating the control and the melanoma groups. Both PCA and OPLS results reveal that the melanoma group can be well separated from its control group. Among the 50 identified metabolites, it is found that the concentrations of 19 metabolites are statistically and significantly changed with the levels of O-phosphocholine and hypoxanthine down-regulated while the levels of isoleucine, leucine, valine, isobutyrate, threonine, cadaverine, alanine, glutamate, glutamine, methionine, citrate, asparagine, tryptophan, glycine, serine, uracil, and formate up-regulated in the melanoma group. These significantly changed metabolites are associated with multiple biological pathways and may be potential biomarkers for metastatic melanoma in stomach.« less

  1. Defect sink characteristics of specific grain boundary types in 304 stainless steels under high dose neutron environments

    SciTech Connect (OSTI)

    Field, Kevin G.; Yang, Ying; Allen, Todd R.; Busby, Jeremy T.

    2015-05-01

    Radiation induced segregation (RIS) is a well-studied phenomena which occurs in many structurally relevant nuclear materials including austenitic stainless steels. RIS occurs due to solute atoms preferentially coupling to mobile point defect fluxes that migrate and interact with defect sinks. Here, a 304 stainless steel was neutron irradiated up to 47.1 dpa at 320 °C. Investigations into the RIS response at specific grain boundary types were utilized to determine the sink characteristics of different boundary types as a function of irradiation dose. A rate theory model built on the foundation of the modified inverse Kirkendall (MIK) model is proposed and benchmarked to the experimental results. This model, termed the GiMIK model, includes alterations in the boundary conditions based on grain boundary structure and includes expressions for interstitial binding. This investigation, through experiment and modeling, found specific grain boundary structures exhibit unique defect sink characteristics depending on their local structure. Such interactions were found to be consistent across all doses investigated and had larger global implications including precipitation of Ni-Si clusters near different grain boundary types.

  2. Advances in molecular serotyping and subtyping of Escherichia coli

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fratamico, Pina M.; DebRoy, Chitrita; Liu, Yanhong; Needleman, David S.; Baranzoni, Gian Marco; Feng, Peter

    2016-05-03

    Escherichia coli plays an important role as a member of the gut microbiota; however, pathogenic strains also exist, including various diarrheagenic E. coli pathotypes and extraintestinal pathogenic E. coli that cause illness outside of the GI-tract. E. coli have traditionally been serotyped using antisera against the ca. 186 O-antigens and 53 H-flagellar antigens. Phenotypic methods, including bacteriophage typing and O- and H- serotyping for differentiating and characterizing E. coli have been used for many years; however, these methods are generally time consuming and not always accurate. Advances in next generation sequencing technologies have made it possible to develop genetic-based subtypingmore » and molecular serotyping methods for E. coli, which are more discriminatory compared to phenotypic typing methods. Furthermore, whole genome sequencing (WGS) of E. coli is replacing established subtyping methods such as pulsedfield gel electrophoresis, providing a major advancement in the ability to investigate food-borne disease outbreaks and for trace-back to sources. Furthermore, a variety of sequence analysis tools and bioinformatic pipelines are being developed to analyze the vast amount of data generated by WGS and to obtain specific information such as O- and H-group determination and the presence of virulence genes and other genetic markers.« less

  3. Regulatory analysis for the resolution of Generic Issue 143: Availability of chilled water system and room cooling

    SciTech Connect (OSTI)

    Leung, V.T.

    1993-12-01

    This report presents the regulatory analysis for Generic Issue (GI-143), {open_quotes}Availability of Chilled Water System and Room Cooling.{close_quotes} The heating, ventilating, and air conditioning (HVAC) systems and related auxiliaries are required to provide control of environmental conditions in areas in light water reactor (LWR) plants that contain safety-related equipment. In some plants, the HVAC and chilled water systems serve to maintain a suitable environment for both safety and non-safety-related areas. Although some plants have an independent chilled water system for the safety-related areas, the heat removal capability often depends on the operability of other supporting systems such as the service water system or the component cooling water system. The operability of safety-related components depends upon operation of the HVAC and chilled water systems to remove heat from areas containing the equipment. If cooling to dissipate the heat generated is unavailable, the ability of the safety-related equipment to operate as intended cannot be assured. Typical components or areas in the nuclear power plant that could be affected by the failure of cooling from HVAC or chilled water systems include the (1) emergency switchgear and battery rooms, (2) emergency diesel generator room, (3) pump rooms for residual heat removal, reactor core isolation cooling, high-pressure core spray, and low-pressure core spray, and (4) control room. The unavailability of such safety-related equipment or areas could cause the core damage frequency (CDF) to increase significantly.

  4. Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy

    SciTech Connect (OSTI)

    Hu, M; Wang, Xiliang

    2014-12-05

    Melanoma is a malignant tumor of melanocytes with high capability of invasion and rapid metastasis to other organs. Malignant melanoma is the most common metastatic malignancy found in gastrointestinal tract (GI). To the best of our knowledge, previous studies of melanoma in gastrointestinal tract are all clinical case reports. In this work, 1H NMR-based metabolomics approach is used to investigate the metabolite profiles differences of stomach tissue extracts of metastatic B16-F10 melanoma in C57BL/6J mouse and search for specific metabolite biomarker candidates. Principal Component Analysis (PCA), an unsupervised multivariate data analysis method, is used to detect possible outliers, while Orthogonal Projection to Latent Structure (OPLS), a supervised multivariate data analysis method, is employed to evaluate important metabolites responsible for discriminating the control and the melanoma groups. Both PCA and OPLS results reveal that the melanoma group can be well separated from its control group. Among the 50 identified metabolites, it is found that the concentrations of 19 metabolites are statistically and significantly changed with the levels of O-phosphocholine and hypoxanthine down-regulated while the levels of isoleucine, leucine, valine, isobutyrate, threonine, cadaverine, alanine, glutamate, glutamine, methionine, citrate, asparagine, tryptophan, glycine, serine, uracil, and formate up-regulated in the melanoma group. These significantly changed metabolites are associated with multiple biological pathways and may be potential biomarkers for metastatic melanoma in stomach.

  5. Mechanisms underlying cellular responses of cells from haemopoietic tissue to low

    SciTech Connect (OSTI)

    Kadhim, Munira A

    2012-08-22

    The above studies will provide fundamental mechanistic information relating genetic predisposition to important low dose phenomena, and will aid in the development of Department of Energy policy, as well as radiation risk policy for the public and the workplace. We believe the proposed studies accurately reflect the goals of the DOE low dose program. To accurately define the risks associated with human exposure to relevant environmental doses of low LET ionizing radiation, it is necessary to completely understand the biological effects at very low doses (i.e. less than 0.1 Gy), including the lowest possible dose, that of a single electron track traversal. At such low doses, a range of studies have shown responses in biological systems which are not related to the direct interaction of radiation tracks with DNA. The role of these "œnon-targeted" responses in critical tissues is poorly understood and little is known regarding the underlying mechanisms. Although critical for dosimetry and risk assessment, the role of individual genetic susceptibility in radiation risk is not satisfactorily defined at present. The aim of the proposed grant is to critically evaluate non-targeted effects of ionizing radiation with a focus on the induction of genomic instability (GI) in key stem cell populations from haemopoietic tissue. Using stem cells from two mouse strains (CBA/CaH and C57BL/6J) known to differ in their susceptibility to radiation effects, we plan to carefully dissect the role of genetic predisposition in these models on genomic instability. We will specifically focus on the effects of low doses of low LET radiation, down to the dose of 10mGy (0.01Gy) X-rays. Using conventional X-ray and we will be able to assess the role of genetic variation under various conditions at a range of doses down to the very low dose of 0.01Gy. Irradiations will be carried out using facilities in routine operation for such studies. Mechanistic studies of instability in

  6. Adaptive nonlocal means filtering based on local noise level for CT denoising

    SciTech Connect (OSTI)

    Li, Zhoubo; Trzasko, Joshua D.; Lake, David S.; Blezek, Daniel J.; Manduca, Armando; Yu, Lifeng; Fletcher, Joel G.; McCollough, Cynthia H.

    2014-01-15

    shape and peak frequency of the noise power spectrum better than commercial smoothing kernels, and indicate that the spatial resolution at low contrast levels is not significantly degraded. Both the subjective evaluation using the ACR phantom and the objective evaluation on a low-contrast detection task using a CHO model observer demonstrate an improvement on low-contrast performance. The GPU implementation can process and transfer 300 slice images within 5 min. On patient data, the adaptive NLM algorithm provides more effective denoising of CT data throughout a volume than standard NLM, and may allow significant lowering of radiation dose. After a two week pilot study of lower dose CT urography and CT enterography exams, both GI and GU radiology groups elected to proceed with permanent implementation of adaptive NLM in their GI and GU CT practices. Conclusions: This work describes and validates a computationally efficient technique for noise map estimation directly from CT images, and an adaptive NLM filtering based on this noise map, on phantom and patient data. Both the noise map calculation and the adaptive NLM filtering can be performed in times that allow integration with clinical workflow. The adaptive NLM algorithm provides effective denoising of CT data throughout a volume, and may allow significant lowering of radiation dose.

  7. Biomaterials for the Decorporation of Sr-85 in the Rat

    SciTech Connect (OSTI)

    Levitskaia, Tatiana G.; Creim, Jeffrey A.; Curry, Terry L.; Luders, Teresa; Morris, James E.; Peterson, James M.; Thrall, Karla D.

    2010-09-01

    Although four stable isotopes of strontium occur naturally, strontium-90 is produced by nuclear fission and is present in surface soil around the world as a result of fallout from atmospheric nuclear weapons tests. It can easily transfer to man in the event of a nuclear/radiological emergency or through the plant-animal-human food chain causing long-term exposures. Strontium is chemically and biologically similar to calcium, and is incorporated primarily into bone following internal deposition. Alginic acid (alginate) obtained from seaweed (kelp) extract selectively binds ingested strontium in the GI tract blocking its systemic uptake and reducing distribution to bone in rats, while other natural polysaccharides including chitosan and hyaluronic acid had little in vivo affinity for strontium. Alginate exhibits the unique ability to discriminate between strontium and calcium and has been previously shown to reduce intestinal absorption and skeletal retention of strontium without changing calcium metabolism. In our studies, the effect of commercially available alginate on strontium intestinal absorption was examined. One problem associated with alginate treatment is its limited solubility and gel formation in water. The aqueous solubility of sodium alginate was improved in a sodium chloride/sodium bicarbonate electrolyte solution containing low molecular weight polyethylene glycol (PEG). Furthermore, oral administration of the combined alginate/electrolyte//PEG solution synergistically accelerated removal of internal strontium in rats when compared to treatment with individual sodium alginate/electrolyte or electrolyte/PEG solutions. Importantly, both alginate and PEG are nontoxic, readily available materials that can be easily administered orally in case of a national emergency when potentially large numbers of the population may require medical treatment for internal depositions. Our results suggest further studies to optimize in vivo decorporation performance of

  8. A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices

    SciTech Connect (OSTI)

    Schlosser, Paul M. Sasso, Alan F.

    2014-10-15

    Chronic oral exposure to hexavalent chromium (Cr-VI) in drinking water has been shown to induce tumors in the mouse gastrointestinal (GI) tract and rat oral cavity. The same is not true for trivalent chromium (Cr-III). Thus reduction of Cr-VI to Cr-III in gastric juices is considered a protective mechanism, and it has been suggested that the difference between the rate of reduction among mice, rats, and humans could explain or predict differences in sensitivity to Cr-VI. We evaluated previously published models of gastric reduction and believe that they do not fully describe the data on reduction as a function of Cr-VI concentration, time, and (in humans) pH. The previous models are parsimonious in assuming only a single reducing agent in rodents and describing pH-dependence using a simple function. We present a revised model that assumes three pools of reducing agents in rats and mice with pH-dependence based on known speciation chemistry. While the revised model uses more fitted parameters than the original model, they are adequately identifiable given the available data, and the fit of the revised model to the full range of data is shown to be significantly improved. Hence the revised model should provide better predictions of Cr-VI reduction when integrated into a corresponding PBPK model. - Highlights: • Hexavalent chromium (Cr-VI) reduction in gastric juices is a key detoxifying step. • pH-dependent Cr-VI reduction rates are explained using known chemical speciation. • Reduction in rodents appears to involve multiple pools of electron donors. • Reduction appears to continue after 60 min, although more slowly than initial rates.

  9. CONVERGENCE STUDIES OF MASS TRANSPORT IN DISKS WITH GRAVITATIONAL INSTABILITIES. II. THE RADIATIVE COOLING CASE

    SciTech Connect (OSTI)

    Steiman-Cameron, Thomas Y.; Durisen, Richard H.; Michael, Scott; McConnell, Caitlin R.; Boley, Aaron C. E-mail: durisen@astro.indiana.edu E-mail: carmccon@indiana.edu

    2013-05-10

    We conduct a convergence study of a protoplanetary disk subject to gravitational instabilities (GIs) at a time of approximate balance between heating produced by the GIs and radiative cooling governed by realistic dust opacities. We examine cooling times, characterize GI-driven spiral waves and their resultant gravitational torques, and evaluate how accurately mass transport can be represented by an {alpha}-disk formulation. Four simulations, identical except for azimuthal resolution, are conducted with a grid-based three-dimensional hydrodynamics code. There are two regions in which behaviors differ as resolution increases. The inner region, which contains 75% of the disk mass and is optically thick, has long cooling times and is well converged in terms of various measures of structure and mass transport for the three highest resolutions. The longest cooling times coincide with radii where the Toomre Q has its minimum value. Torques are dominated in this region by two- and three-armed spirals. The effective {alpha} arising from gravitational stresses is typically a few Multiplication-Sign 10{sup -3} and is only roughly consistent with local balance of heating and cooling when time-averaged over many dynamic times and a wide range of radii. On the other hand, the outer disk region, which is mostly optically thin, has relatively short cooling times and does not show convergence as resolution increases. Treatment of unstable disks with optical depths near unity with realistic radiative transport is a difficult numerical problem requiring further study. We discuss possible implications of our results for numerical convergence of fragmentation criteria in disk simulations.

  10. Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice

    SciTech Connect (OSTI)

    Huang, C.-F.; Liu, S.-H.; Lin-Shiau, S.-Y.

    2007-10-15

    Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in combination with traditional Chinese medicine as a sedative for more than 2000 years. Up to date, its pharmacological and toxicological effects are still unclear, especially in clinical low-dose and long-term use. In this study, we attempted to elucidate the effects of cinnabar on the time course of changes in locomotor activities, pentobarbital-induced sleeping time, motor equilibrium performance and neurobiochemical activities in mice during 3- to 11-week administration at a clinical dose of 10 mg/kg/day. The results showed that cinnabar was significantly absorbed by gastrointestinal (G-I) tract and transported to brain tissues. The spontaneous locomotor activities of male mice but not female mice were preferentially suppressed. Moreover, frequencies of jump and stereotype-1 episodes were progressively decreased after 3-week oral administration in male and female mice. Pentobarbital-induced sleeping time was prolonged and the retention time on a rotating rod (60 rpm) was reduced after treatment with cinnabar for 6 weeks and then progressively to a greater extent until the 11-week experiment. In addition, the biochemical changes in blood and brain tissues were studied; the inhibition of Na{sup +}/K{sup +}-ATPase activities, increased production of lipid peroxidation (LPO) and nitric oxide (NO) were found with a greater extent in male mice than those in female mice, which were apparently correlated with their differences in the neurological responses observed. In conclusion, these findings, for the first time, provide evidence of the pharmacological and toxicological basis for understanding the sedative and neurotoxic effects of cinnabar used as a Chinese mineral medicine for more than 2000 years.

  11. Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator

    SciTech Connect (OSTI)

    Nguyen, Y.; Nguyen, Nam X.; Rogers, Jamie L.; Liao, Jun; MacMillan, John B.; Jiang, Youxing; Sperandio, Vanessa

    2015-05-19

    Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However, some bacteria (such as Escherichia coli) do not produce AHLs. These LuxR orphans sense exogenous AHLs but also regulate transcription in the absence of AHLs. Importantly, this AHL-independent regulatory mechanism is still largely unknown. Here we present several structures of one such orphan LuxR-type protein, SdiA, from enterohemorrhagic E. coli (EHEC), in the presence and absence of AHL. SdiA is actually not in an apo state without AHL but is regulated by a previously unknown endogenous ligand, 1-octanoyl-rac-glycerol (OCL), which is ubiquitously found throughout the tree of life and serves as an energy source, signaling molecule, and substrate for membrane biogenesis. While exogenous AHL renders to SdiA higher stability and DNA binding affinity, OCL may function as a chemical chaperone placeholder that stabilizes SdiA, allowing for basal activity. Structural comparison between SdiA-AHL and SdiA-OCL complexes provides crucial mechanistic insights into the ligand regulation of AHL-dependent and -independent function of LuxR-type proteins. Importantly, in addition to its contribution to basic science, this work has implications for public health, inasmuch as the SdiA signaling system aids the deadly human pathogen EHEC to adapt to a commensal lifestyle in the gastrointestinal (GI) tract of cattle, its main reservoir. These studies open exciting and novel avenues to control shedding of this human pathogen in the environment. IMPORTANCE Quorum sensing refers to bacterial chemical signaling. The QS acyl homoserine lactone (AHL) signals are recognized by LuxR-type receptors that regulate gene transcription. However, some bacteria have orphan LuxR-type receptors and

  12. Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Nguyen, Y.; Nguyen, Nam X.; Rogers, Jamie L.; Liao, Jun; MacMillan, John B.; Jiang, Youxing; Sperandio, Vanessa

    2015-05-19

    Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However, some bacteria (such as Escherichia coli) do not produce AHLs. These LuxR orphans sense exogenous AHLs but also regulate transcription in the absence of AHLs. Importantly, this AHL-independent regulatory mechanism is still largely unknown. Here we present several structures of one such orphan LuxR-type protein, SdiA, from enterohemorrhagic E. coli (EHEC), in the presence and absence of AHL. SdiA is actually not inmore » an apo state without AHL but is regulated by a previously unknown endogenous ligand, 1-octanoyl-rac-glycerol (OCL), which is ubiquitously found throughout the tree of life and serves as an energy source, signaling molecule, and substrate for membrane biogenesis. While exogenous AHL renders to SdiA higher stability and DNA binding affinity, OCL may function as a chemical chaperone placeholder that stabilizes SdiA, allowing for basal activity. Structural comparison between SdiA-AHL and SdiA-OCL complexes provides crucial mechanistic insights into the ligand regulation of AHL-dependent and -independent function of LuxR-type proteins. Importantly, in addition to its contribution to basic science, this work has implications for public health, inasmuch as the SdiA signaling system aids the deadly human pathogen EHEC to adapt to a commensal lifestyle in the gastrointestinal (GI) tract of cattle, its main reservoir. These studies open exciting and novel avenues to control shedding of this human pathogen in the environment. IMPORTANCE Quorum sensing refers to bacterial chemical signaling. The QS acyl homoserine lactone (AHL) signals are recognized by LuxR-type receptors that regulate gene transcription. However, some bacteria have orphan Lux

  13. Extracellular acidification synergizes with PDGF to stimulate migration of mouse embryo fibroblasts through activation of p38MAPK with a PTX-sensitive manner

    SciTech Connect (OSTI)

    An, Caiyan; Sato, Koichi; Wu, Taoya; Bao, Muqiri; Bao, Liang; Tobo, Masayuki; Damirin, Alatangaole

    2015-05-01

    The elucidation of the functional mechanisms of extracellular acidification stimulating intracellular signaling pathway is of great importance for developing new targets of treatment for solid tumors, and inflammatory disorders characterized by extracellular acidification. In the present study, we focus on the regulation of extracellular acidification on intracellular signaling pathways in mouse embryo fibroblasts (MEFs). We found extracellular acidification was at least partly involved in stimulating p38MAPK pathway through PTX-sensitive behavior to enhance cell migration in the presence or absence of platelet-derived growth factor (PDGF). Statistical analysis showed that the actions of extracellular acidic pH and PDGF on inducing enhancement of cell migration were not an additive effect. However, we also found extracellular acidic pH did inhibit the viability and proliferation of MEFs, suggesting that extracellular acidification stimulates cell migration probably through proton-sensing mechanisms within MEFs. Using OGR1-, GPR4-, and TDAG8-gene knock out technology, and real-time qPCR, we found known proton-sensing G protein-coupled receptors (GPCRs), transient receptor potential vanilloid subtype 1 (TRPV1), and acid-sensing ion channels (ASICs) were unlikely to be involved in the regulation of acidification on cell migration. In conclusion, our present study validates that extracellular acidification stimulates chemotactic migration of MEFs through activation of p38MAPK with a PTX-sensitive mechanism either by itself, or synergistically with PDGF, which was not regulated by the known proton-sensing GPCRs, TRPV1, or ASICs. Our results suggested that others proton-sensing GPCRs or ion channels might exist in MEFs, which mediates cell migration induced by extracellular acidification in the presence or absence of PDGF. - Highlights: • Acidic pH and PDGF synergize to stimulate MEFs migration via Gi/p38MAPK pathway. • Extracellular acidification inhibits the

  14. SU-E-T-629: Feasibility Study of Treating Multiple Brain Tumors with Large Number of Noncoplanar IMRT Beams

    SciTech Connect (OSTI)

    Dong, P; Ma, L

    2014-06-15

    Purpose: To study the feasibility of treating multiple brain tumors withlarge number of noncoplanar IMRT beams. Methods: Thirty beams are selected from 390 deliverable beams separated by six degree in 4pi space. Beam selection optimization is based on a column generation algorithm. MLC leaf size is 2 mm. Dose matrices are calculated with collapsed cone convolution and superposition method in a 2 mm by 2mm by 2 mm grid. Twelve brain tumors of various shapes, sizes and locations are used to generate four plans treating 3, 6, 9 and 12 tumors. The radiation dose was 20 Gy prescribed to the 100% isodose line. Dose Volume Histograms for tumor and brain were compared. Results: All results are based on a 2 mm by 2 mm by 2 mm CT grid. For 3, 6, 9 and 12 tumor plans, minimum tumor doses are all 20 Gy. Mean tumor dose are 20.0, 20.1, 20.1 and 20.1 Gy. Maximum tumor dose are 23.3, 23.6, 25.4 and 25.4 Gy. Mean ventricles dose are 0.7, 1.7, 2.4 and 3.1 Gy.Mean subventricular zone dose are 0.8, 1.3, 2.2 and 3.2 Gy. Average Equivalent uniform dose (gEUD) values for tumor are 20.1, 20.1, 20.2 and 20.2 Gy. The conformity index (CI) values are close to 1 for all 4 plans. The gradient index (GI) values are 2.50, 2.05, 2.09 and 2.19. Conclusion: Compared with published Gamma Knife treatment studies, noncoplanar IMRT treatment plan is superior in terms of dose conformity. Due to maximum limit of beams per plan, Gamma knife has to treat multiple tumors separately in different plans. Noncoplanar IMRT plans theoretically can be delivered in a single plan on any modern linac with an automated couch and image guidance. This warrants further study of using noncoplanar IMRT as a viable treatment solution for multiple brain tumors.

  15. Five Fractions of Radiation Therapy Followed by 4 Cycles of FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer

    SciTech Connect (OSTI)

    Myerson, Robert J.; Tan, Benjamin; Hunt, Steven; Olsen, Jeffrey; Birnbaum, Elisa; Fleshman, James; Gao, Feng; Hall, Lannis; Kodner, Ira; Lockhart, A. Craig; Mutch, Matthew; Naughton, Michael; Picus, Joel; Rigden, Caron; Safar, Bashar; Sorscher, Steven; Suresh, Rama; Wang-Gillam, Andrea; Parikh, Parag

    2014-03-15

    Background: Preoperative radiation therapy with 5-fluorouracil chemotherapy is a standard of care for cT3-4 rectal cancer. Studies incorporating additional cytotoxic agents demonstrate increased morbidity with little benefit. We evaluate a template that: (1) includes the benefits of preoperative radiation therapy on local response/control; (2) provides preoperative multidrug chemotherapy; and (3) avoids the morbidity of concurrent radiation therapy and multidrug chemotherapy. Methods and Materials: Patients with cT3-4, any N, any M rectal cancer were eligible. Patients were confirmed to be candidates for pelvic surgery, provided response was sufficient. Preoperative treatment was 5 fractions radiation therapy (25 Gy to involved mesorectum, 20 Gy to elective nodes), followed by 4 cycles of FOLFOX [5-fluorouracil, oxaliplatin, leucovorin]. Extirpative surgery was performed 4 to 9 weeks after preoperative chemotherapy. Postoperative chemotherapy was at the discretion of the medical oncologist. The principal objectives were to achieve T stage downstaging (ypT < cT) and preoperative grade 3+ gastrointestinal morbidity equal to or better than that of historical controls. Results: 76 evaluable cases included 7 cT4 and 69 cT3; 59 (78%) cN+, and 7 cM1. Grade 3 preoperative GI morbidity occurred in 7 cases (9%) (no grade 4 or 5). Sphincter-preserving surgery was performed on 57 (75%) patients. At surgery, 53 patients (70%) had ypT0-2 residual disease, including 21 (28%) ypT0 and 19 (25%) ypT0N0 (complete response); 24 (32%) were ypN+. At 30 months, local control for all evaluable cases and freedom from disease for M0 evaluable cases were, respectively, 95% (95% confidence interval [CI]: 89%-100%) and 87% (95% CI: 76%-98%). Cases were subanalyzed by whether disease met requirements for the recently activated PROSPECT trial for intermediate-risk rectal cancer. Thirty-eight patients met PROSPECT eligibility and achieved 16 ypT0 (42%), 15 ypT0N0 (39%), and 33 ypT0-2 (87

  16. CHP Integrated with Burners for Packaged Boilers

    SciTech Connect (OSTI)

    Castaldini, Carlo; Darby, Eric

    2013-09-30

    division of Sempra Energy. These match funds were provided via concurrent contracts and investments available via CMCE, Altex, and Leva Energy The project attained all its objectives and is considered a success. CMCE secured the support of GI&E from Italy to supply 100 kW Turbec T-100 microturbines for the project. One was purchased by the project’s subcontractor, Altex, and a second spare was purchased by CMCE under this project. The microturbines were then modified to convert from their original recuperated design to a simple cycle configuration. Replacement low-NOx silo combustors were designed and bench tested in order to achieve compliance with the California Air Resources Board (CARB) 2007 emission limits for NOx and CO when in CHP operation. The converted microturbine was then mated with a low NOx burner provided by Altex via an integration section that allowed flow control and heat recovery to minimize combustion blower requirements; manage burner turndown; and recover waste heat. A new fully integrated control system was designed and developed that allowed one-touch system operation in all three available modes of operation: (1) CHP with both microturbine and burner firing for boiler heat input greater than 2 MMBtu/hr; (2) burner head only (BHO) when the microturbine is under service; and (3) microturbine only when boiler heat input requirements fall below 2 MMBtu/hr. This capability resulted in a burner turndown performance of nearly 10/1, a key advantage for this technology over conventional low NOx burners. Key components were then assembled into a cabinet with additional support systems for generator cooling and fuel supply. System checkout and performance tests were performed in the laboratory. The assembled system and its support equipment were then shipped and installed at a host facility where final performance tests were conducted following efforts to secure fabrication, air, and operating permits. The installed power burner is now in commercial

  17. Multifunctional Metallic and Refractory Materials for Energy Efficient Handling of Molten Metals

    SciTech Connect (OSTI)

    Xingbo Liu; Ever Barbero; Bruce Kang; Bhaskaran Gopalakrishnan; James Headrick; Carl Irwin

    2009-02-06

    The goal of the project was to extend the lifetime of hardware submerged in molten metal by an order of magnitude and to improve energy efficiency of molten metal handling process. Assuming broad implementation of project results, energy savings in 2020 were projected to be 10 trillion BTU/year, with cost savings of approximately $100 million/year. The project team was comprised of materials research groups from West Virginia University and the Missouri University of Science and Technology formerly University of Missouri – Rolla, Oak Ridge National Laboratory, International Lead and Zinc Research Organization, Secat and Energy Industries of Ohio. Industry partners included six suppliers to the hot dip galvanizing industry, four end-user steel companies with hot-dip Galvanize and/or Galvalume lines, eight refractory suppliers, and seven refractory end-user companies. The results of the project included the development of: (1) New families of materials more resistant to degradation in hot-dip galvanizing bath conditions were developed; (2) Alloy 2020 weld overlay material and process were developed and applied to GI rolls; (3) New Alloys and dross-cleaning procedures were developed for Galvalume processes; (4) Two new refractory compositions, including new anti-wetting agents, were identified for use with liquid aluminum alloys; (5) A new thermal conductivity measurement technique was developed and validated at ORNL; (6) The Galvanizing Energy Profiler Decision Support System (GEPDSS)at WVU; Newly Developed CCW Laser Cladding Shows Better Resistance to Dross Buildup than 316L Stainless Steel; and (7) A novel method of measuring the corrosion behavior of bath hardware materials. Project in-line trials were conducted at Southwire Kentucky Rod and Cable Mill, Nucor-Crawfordsville, Nucor-Arkansas, Nucor-South Carolina, Wheeling Nisshin, California Steel, Energy Industries of Ohio, and Pennex Aluminum. Cost, energy, and environmental benefits resulting from the project

  18. Overview of the design, construction, and operation of interstate liquid petroleum pipelines.

    SciTech Connect (OSTI)

    Pharris, T. C.; Kolpa, R. L.

    2008-01-31

    /International Arctic Research Center, both located in Fairbanks (Barboza and Trebelhorn 2001), available electronically at http://www.gi.alaska.edu/services/library/pipeline.html codes. The Association of Oil Pipe Lines (AOPL) and the American Petroleum Institute (API) jointly provide an overview covering the life cycle of design, construction, operations, maintenance, economic regulation, and deactivation of liquid pipelines (AOPL/API 2007).

  19. Central and Eastern United States (CEUS) Seismic Source Characterization (SSC) for Nuclear Facilities Project

    SciTech Connect (OSTI)

    Kevin J. Coppersmith; Lawrence A. Salomone; Chris W. Fuller; Laura L. Glaser; Kathryn L. Hanson; Ross D. Hartleb; William R. Lettis; Scott C. Lindvall; Stephen M. McDuffie; Robin K. McGuire; Gerry L. Stirewalt; Gabriel R. Toro; Robert R. Youngs; David L. Slayter; Serkan B. Bozkurt; Randolph J. Cumbest; Valentina Montaldo Falero; Roseanne C. Perman' Allison M. Shumway; Frank H. Syms; Martitia P. Tuttle

    2012-01-31

    Seismic Hazard Analysis: Guidance on Uncertainty and Use of Experts. The model will be used to assess the present-day composite distribution for seismic sources along with their characterization in the CEUS and uncertainty. In addition, this model is in a form suitable for use in PSHA evaluations for regulatory activities, such as Early Site Permit (ESPs) and Combined Operating License Applications (COLAs). Applications, Values, and Use Development of a regional CEUS seismic source model will provide value to those who (1) have submitted an ESP or COLA for Nuclear Regulatory Commission (NRC) review before 2011; (2) will submit an ESP or COLA for NRC review after 2011; (3) must respond to safety issues resulting from NRC Generic Issue 199 (GI-199) for existing plants and (4) will prepare PSHAs to meet design and periodic review requirements for current and future nuclear facilities. This work replaces a previous study performed approximately 25 years ago. Since that study was completed, substantial work has been done to improve the understanding of seismic sources and their characterization in the CEUS. Thus, a new regional SSC model provides a consistent, stable basis for computing PSHA for a future time span. Use of a new SSC model reduces the risk of delays in new plant licensing due to more conservative interpretations in the existing and future literature. Perspective The purpose of this study, jointly sponsored by EPRI, the U.S. Department of Energy (DOE), and the NRC was to develop a new CEUS SSC model. The team assembled to accomplish this purpose was composed of distinguished subject matter experts from industry, government, and academia. The resulting model is unique, and because this project has solicited input from the present-day larger technical community, it is not likely that there will be a need for significant revision for a number of years. See also Sponsors Perspective for more details. The goal of this project was to implement the CEUS SSC work plan