Sample records for hutchinson cancer research

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington: Laboratories for the 21st Century Case Studies (Revision)

    SciTech Connect (OSTI)

    Not Available

    2002-03-01T23:59:59.000Z

    This case study was prepared by participants in the Laboratories for the 21st Century program, a joint endeavor of the U.S. Environmental Protection Agency and the U.S. Department of Energy's Federal Energy Management Program. The goal of this program is to foster greater energy efficiency in new laboratory buildings for both the public and the private sectors. Retrofits of existing laboratories are also encouraged. The energy-efficient features of the laboratories in the Fred Hutchinson Cancer Research Center complex in Seattle, Washington, include extensive use of efficient lighting, variable-air-volume controls, variable-speed drives, motion sensors, and high-efficiency chillers and motors. With about 532,000 gross square feet, the complex is estimated to use 33% less electrical energy than most traditional research facilities consume because of its energy-efficient design and features.

  2. Fred Hutchinson Cancer Research Center, Seattle, Washington: Laboratories for the 21st Century Case Studies

    SciTech Connect (OSTI)

    Not Available

    2001-12-01T23:59:59.000Z

    This case study was prepared by participants in the Laboratories for the 21st Century program, a joint endeavor of the U.S. Environmental Protection Agency and the U.S. Department of Energy's Federal Energy Management Program. The goal of this program is to foster greater energy efficiency in new laboratory buildings for both the public and the private sectors. Retrofits of existing laboratories are also encouraged. The energy-efficient features of the laboratories in the Fred Hutchinson Cancer Research Center complex in Seattle, Washington, include extensive use of efficient lighting, variable-air-volume controls, variable-speed drives, motion sensors, and high-efficiency chillers and motors. With about 532,000 gross square feet, the complex is estimated to use 33% less electrical energy than most traditional research facilities consume because of its energy-efficient design and features.

  3. The University of Washington and the Fred Hutchinson Cancer Research Center Announce the

    E-Print Network [OSTI]

    Kaminsky, Werner

    and return the application via email with requested secondary materials to: Dr. Gabriele Varani, Department States, and for the identification and resolution of health care disparities. Thus, we are committed to biomedical research is particularly strong and the academic trajectory of the student is positive. PREP

  4. Hutchinson Utilities Commission- Commercial Energy Efficiency Program

    Broader source: Energy.gov [DOE]

    Hutchinson Utilities Commission (HUC) offers rebates to commercial customers in Hutchinson who perform energy conservation improvements to their businesses. These rebates are limited to one...

  5. Cancer Research Beckman Institute

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

  6. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Berdichevsky, Victor

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  7. Hutchinson Utilities Commission- Residential Energy Efficiency Program

    Broader source: Energy.gov [DOE]

    Hutchinson Utilities Commission (HUC) offers a rebate of up to $500 to residents of Hutchinson who perform energy conservation improvements to their home. Rebates are available for a variety of...

  8. Exploring the Relationship between Neutral and Selective Mutations in Cancer

    E-Print Network [OSTI]

    Forrest, Stephanie

    Exploring the Relationship between Neutral and Selective Mutations in Cancer C. C. Maley 1;2 and S. Forrest 2;3 (cmaley@alum.mit.edu and forrest@cs.unm.edu) 1 Fred Hutchinson Cancer Research Center 1100 of normal cells into cancerous cells is an evolu- tionary process. Populations of precancerous cells

  9. Cancer Imaging Clinical Cancer Research

    E-Print Network [OSTI]

    Near Ir; Heptamethine Cyanine Dye–mediated; Xiaojian Yang; Chunmeng Shi; Rong Tong; Weiping Qian; Haiyen E. Zhau; Ruoxiang Wang; Guodong Zhu; Jianjun Cheng; Vincent W. Yang; Tianmin Cheng; Maged Henary; Lucjan Strekowski; W. K. Chung

    Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. Experimental Design: IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. Time- and concentration-dependent dye uptake and retention in normal and cancer cells and tissues were compared, and subcellular localization of the dyes and mechanisms of the dye uptake and retention in tumor cells were evaluated using organelle-specific tracking dyes and bromosulfophthalein, a competitive inhibitor of organic anion transporting peptides. These dyes were used to detect human cancer metastases in a mouse model and differentiate cancer cells from normal cells in blood. Results: These near-IR hepatamethine cyanine dyes were retained in cancer cells but not normal cells, in tumor xenografts, and in spontaneous tumors in transgenic mice. They can be used to detect cancer metastasis and cancer cells in blood with a high degree of sensitivity. The dyes were found to concentrate in the mitochondria and lysosomes of cancer cells, probably through organic anion transporting peptides,

  10. Paul Workman Cancer Research UK Cancer Therapeutics Unit

    E-Print Network [OSTI]

    Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

  11. Detecting Intrusion Faults in Remotely Controlled Systems Salvatore Candido and Seth Hutchinson

    E-Print Network [OSTI]

    Hutchinson, Seth

    the design process. With this in mind, researchers have begun to address security issues specific to controlDetecting Intrusion Faults in Remotely Controlled Systems Salvatore Candido and Seth Hutchinson to a remote-controlled system (deemed an "intrusion fault" or "intrusion") despite attempts to conceal

  12. Hutchinson, Kansas Revitalized by Clean Energy Jobs | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Addthis Employees speak about the changes happening in their lives since a wind turbine component manufacturing facility came to Hutchinson, Kansas. | Video courtesy of...

  13. Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°,Hutchinson,

  14. Breast Cancer Research Finding Answers. Finding Cures.

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  15. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  16. Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1

    E-Print Network [OSTI]

    Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Cancer Research UK electronic Grants Management System (e://egms.cancerresearchuk.org #12;Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 2

  17. 'ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    'ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract.We clarify the relationship between higher 'etale wild kernels * *of a number- cyclotomic tower of the field. We also determine the relationship betwee* *n the 'etale wild kernel

  18. Robin Hutchinson, Gamil Tadros, Jadwiga Kroman, Sami Rizkalla, "Use of Externally Bonded FRP Systems for Rehabilitation of Bridges in Western Canada," Page 1

    E-Print Network [OSTI]

    Systems for Rehabilitation of Bridges in Western Canada," Page 1 Use of Externally Bonded FRP Systems for Rehabilitation of Bridges in Western Canada Robin Hutchinson, Gamil Tadros, Jadwiga Kroman, Sami Rizkalla Synopsis: Since its inception in 1995, the ISIS Canada research network has developed design procedures

  19. Distribution and Abstract Types in Emerald N. Hutchinson

    E-Print Network [OSTI]

    Black, Andrew P.

    Distribution and Abstract Types in Emerald A. Black N. Hutchinson E. Jul H. Levy L. CarterEEE TRANSACTIONS ON SOFTWARE ENGINEERING, VOL. SE-13. NO. 1, JANUARY 1987 65 Distribution and Abstract Types-Emerald is an object-based language for programming distributed subsystems and applications. Its novel features include

  20. ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    #19; ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract. We clarify the relationship between higher #19;etale wild kernels of a number #12;eld at the prime 2 and the Galois between the #19;etale wild kernel and the group of in#12;nitely divisible elements of H 2 (F; Z 2 (j + 1

  1. ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    ´ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract. We clarify the relationship between higher ´etale wild kernels of a number field at the prime 2 and the Galois between the ´etale wild kernel and the group of infinitely divisible elements of H2 (F, Z2(j + 1)){2}. 1

  2. Plasticity at the micron scale John W. Hutchinson*

    E-Print Network [OSTI]

    Hutchinson, John W.

    Plasticity at the micron scale John W. Hutchinson* Division of Engineering and Applied Sciences into the plastic range: smaller is stronger. This eect has important implications for an increasing number of applications in electronics, structural materials and MEMS. Plastic behavior at this scale cannot

  3. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    treatments and biomarkers for cancer. The CRCTU also collaborate with a large number of academic scientificContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University://www.birmingham.ac.uk/crctu Making a difference... A National Cancer Research Institute Accredited Trials Unit Linked Groups

  4. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    scientists in the development of new treatments and biomarkers for cancer. The CRCTU also collaborateContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University... A National Cancer Research Institute Accredited Trials Unit Linked Groups @CRCTUCRCTU Birmingham

  5. Isotope Cancer Treatment Research at LANL

    ScienceCinema (OSTI)

    Weidner, John; Nortier, Meiring

    2014-06-02T23:59:59.000Z

    Los Alamos National Laboratory has produced medical isotopes for diagnostic and imaging purposes for more than 30 years. Now LANL researchers have branched out into isotope cancer treatment studies. New results show that an accelerator-based approach can produce clinical trial quantities of actinium-225, an isotope that has promise as a way to kill tumors without damaging surrounding healthy cells.

  6. Animal Cancer Care and Research Program Summer 2011

    E-Print Network [OSTI]

    Minnesota, University of

    Synergy Animal Cancer Care and Research Program Summer 2011 Michael G. Conzemius, D.V.M., Ph Cancer Care and Research Program 2 · Synergy Summer 2011 COTC016: A pilot study to assess feasibility Clinical Sciences, College of Veterinary Medicine and Masonic Cancer Center T he University of Minnesota

  7. The Emerald Programming Language1 Norman C. Hutchinson, Rajendra K. Raj,

    E-Print Network [OSTI]

    Black, Andrew P.

    The Emerald Programming Language1 REPORT Norman C. Hutchinson, Rajendra K. Raj, Andrew P. Black addresses: Norman Hutchinson, Department of Computer Science, University of Ari- zona, Tucson, AZ 85721. Andrew Black, Digital Equipment Corporation, 550 King Street, Littleton, MA 01460. Eric Jul, DIKU

  8. DOE/EA-0965 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER

    Broader source: Energy.gov (indexed) [DOE]

    65 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER INDIANA UNIVERSITY SCHOOL OF MEDICINE PREPARED BY U.S. DEPARTMENT O F ENERGY, CHICAGO FIELD OFFICE PROGRAMS AND FACILITIES...

  9. [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief

    E-Print Network [OSTI]

    Jin, Jiashun

    [CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

  10. Friday, April 29, 2011 UNM Research Looks at Cancer

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Friday, April 29, 2011 UNM Research Looks at Cancer By Olivier Uyttebrouck Copyright © 2011 Albuquerque Journal Journal Staff Writer Chemotherapy can save the lives of cancer patients, but side effects are developing a technique they say can deliver minute amounts of cancer-fighting drugs directly into a diseased

  11. RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer cells by E Klinck5 , François A Auger4 and Jacques Huot1* Abstract Background: Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells

  12. ADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer Research Program

    E-Print Network [OSTI]

    cancer biology suggest that a single treatment approach for this heterogeneous and biologically complex cancer is not ideal. In the future, the best treatments may be determined by the molecular determinantsADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer

  13. SysBioMed Canary Islands Cancer Research

    E-Print Network [OSTI]

    Timmer, Jens

    SysBioMed Canary Islands Cancer Research Institute Winter School on Systems Biology for Medical Applications 27th February ­ 2nd March 2007 Puerto de la Cruz, Tenerife (Canary Islands) Supported by the European Commission (FP6 projects COSBICS and SysBioMed) and the Canary Islands Institute for Cancer

  14. Genomics at the Ontario Institute for Cancer Research

    SciTech Connect (OSTI)

    Ali, Johar [Ontario Institute for Cancer Research

    2010-06-02T23:59:59.000Z

    Johar Ali of the Ontario Institute for Cancer Research discusses genomics and next-gen applications at the OICR on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  15. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

  16. Changing the Face of Cancer through investments in research, education, outreach and care

    E-Print Network [OSTI]

    Chapman, Michael S.

    this progress. Gifts: · Advance the studies of new cancer treatments · Recruit and keep talented researchersChanging the Face of Cancer through investments in research, education, outreach and care Giving Guide #12;OHSU Knight Cancer Institute We Will End Cancer As We Know It The OHSU Knight Cancer Institute

  17. AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day

    E-Print Network [OSTI]

    Sherman, S. Murray

    AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org #12;AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org Also published as: American Association for Cancer Research. AACR cancer progress report

  18. Fine-Grained Mobility in the Emerald System Eric :lul, Henry Levy, Norman Hutchinson, and Andrew Black*

    E-Print Network [OSTI]

    Black, Andrew P.

    Fine-Grained Mobility in the Emerald System Eric :lul, Henry Levy, Norman Hutchinson, and Andrew of Copenhagen, Universitetparken 1, DK- 2100 Copenhagen, Denmark. Norman Hutchinson, Depart- ment of Computer Science, University of Arizona, Tucson, AZ 85721. Andrew Black, Digital Equipment Corporation, 550 King

  19. This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs.

    E-Print Network [OSTI]

    Sonnenburg, Justin L.

    's cancer. In addition to cancer treatment, supportive services--including social services, psychological of the triple negative breast cancer. The Stanford Gynecologic Oncology Program offers treatments and clinical Group (COGi), a national cooperative research group for innovative treatments in ovarian cancer

  20. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home asLCLSLaboratoryRowlandRevolutionizingLaserLaserCancer

  1. DEPARTMENT OF DEFENSE LUNG CANCER RESEARCH PROGRAM FISCAL YEAR 2013 STRATEGIC PLAN

    E-Print Network [OSTI]

    von der Heydt, Rüdiger

    DEPARTMENT OF DEFENSE LUNG CANCER RESEARCH PROGRAM FISCAL YEAR 2013 STRATEGIC PLAN The Fiscal Year 2013 (FY13) Defense Appropriations Act provides for $10.5 million to the Department of Defense Lung Cancer Research Program (LCRP) to support innovative, high- impact lung cancer research. This program

  2. RESEARCH Open Access Analysis of primary risk factors for oral cancer

    E-Print Network [OSTI]

    Ahmad, Sajjad

    RESEARCH Open Access Analysis of primary risk factors for oral cancer from select US states , Michelle Chino3 , Karl Kingsley1* Abstract Objectives: To examine the primary risk factor for oral cancer in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity

  3. Cancer, Palliative and End of Life Care ResearchProjects2012

    E-Print Network [OSTI]

    Anderson, Jim

    Cancer, Palliative and End of Life Care ResearchProjects2012 #12;2 5 4 Cancer, Palliative and End and students working together to transform care and improve outcomes for individuals affected by cancer, other the right questions to generate theory, influence policy and change practice. Cancer survivorship

  4. A Data Synchronization Service for Ad Hoc Groups Terry Coatta, Norman C. Hutchinson, Andrew Warfield and Joseph H. T. Wong

    E-Print Network [OSTI]

    Warfield, Andrew

    A Data Synchronization Service for Ad Hoc Groups Terry Coatta, Norman C. Hutchinson, Andrew: norm@cs.ubc.ca Computer Laboratory, University of Cambridge, Cambridge, United Kingdom Email: andrew

  5. Saving Adam With Pediatric Cancer Research | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementingnpitcheResearch Briefs TheSanket A.LittleFY13 | NationalSave

  6. Cancer Research Institute, Loma Linda University Medical Center

    SciTech Connect (OSTI)

    NONE

    1994-08-01T23:59:59.000Z

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA) DOE/EA-0975, evaluating the construction, equipping and operation of the Cancer Research Institute (CRI) at the Loma Linda University Medical Center (LLUMC) on its campus in Loma Linda, California. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an Environmental Impact Statement is not required. This document describes alternatives, the affected environment and environmental consequences of the proposed action.

  7. [CANCER RESEARCH 52. 6394-63%. November 15. 1992] Advances in Brief

    E-Print Network [OSTI]

    [CANCER RESEARCH 52. 6394-63%. November 15. 1992] Advances in Brief Induction of Sister Chromatid of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115 Abstract The induction 1734 solely to indicate this fact. 1Supported by Grant PDT-440 from the American Cancer Society

  8. A Distributed Biomarker Atlas for Lung Research aiding the Discovery and Early Detection of Cancer Biomarkers

    E-Print Network [OSTI]

    Mattmann, Chris

    A Distributed Biomarker Atlas for Lung Research aiding the Discovery and Early Detection of Cancer Atlas software system that allows a researcher to correlate lung cancer patients with similar characteristics around regions of the lung in which their sample specimens including multiple types

  9. A review of "The Works of Lucy Hutchinson" edited by Reid Barbour and David Norbrook 

    E-Print Network [OSTI]

    Caldwell, Tanya

    2013-01-01T23:59:59.000Z

    exercise in textual engagement. Reid Barbour and David Norbrook, eds. #31;e Works of Lucy Hutchinson. Volume I: Translation of Lucretius. #18; parts. Latin text ed. by Maria Cristina Zerbino. Oxford: Oxford University Press, #18;#17;#16;#18;. cxlvi + #31... of the books of her translation. #2;ese are each prefaced by an argument and juxtaposed with the Latin text that she used, prepared by Maria Cristina Zerbino. #2;e translation appears on the right hand page and the Latin on the left. #2;e texts...

  10. A review of "The Works of Lucy Hutchinson" edited by Reid Barbour and David Norbrook

    E-Print Network [OSTI]

    Caldwell, Tanya

    2013-01-01T23:59:59.000Z

    exercise in textual engagement. Reid Barbour and David Norbrook, eds. #31;e Works of Lucy Hutchinson. Volume I: Translation of Lucretius. #18; parts. Latin text ed. by Maria Cristina Zerbino. Oxford: Oxford University Press, #18;#17;#16;#18;. cxlvi + #31... of the books of her translation. #2;ese are each prefaced by an argument and juxtaposed with the Latin text that she used, prepared by Maria Cristina Zerbino. #2;e translation appears on the right hand page and the Latin on the left. #2;e texts...

  11. WSRF-Based Modeling of Clinical Trial Information for Collaborative Cancer Research

    E-Print Network [OSTI]

    Oxford, University of

    descriptions of clinical outcomes. The information technology needed to enable this kind of largeWSRF-Based Modeling of Clinical Trial Information for Collaborative Cancer Research Tianyi Zang1 clinical trials. This paper presents the service-oriented software paradigm implemented in Cancer

  12. EA-0965: Cancer Research Center Indiana University School of Medicine, Argonne, Illinois

    Broader source: Energy.gov [DOE]

    This EA evaluates the environmental impacts of the proposal to construct and equip the proposed Cancer Research Center (CRC), which would be located on the Indianapolis campus of the Indiana...

  13. The Damon Runyon Cancer Research Foundation Clinical Investigator Award Program Dear Colleagues,

    E-Print Network [OSTI]

    Spence, Harlan Ernest

    are not eligible to apply. · The applicant must commit to spending 80% of their time conducting research sources to support their research. However, no other physician- scientist career development award fromThe Damon Runyon Cancer Research Foundation Clinical Investigator Award Program Dear Colleagues

  14. The Cancer Prevention Research Institute of Texas (CPRIT) has awarded the Texas A&M AgriLife

    E-Print Network [OSTI]

    The Cancer Prevention Research Institute of Texas (CPRIT) has awarded the Texas A&M Agri American Cancer Society screening standards. Friend to Friend is a research tested, best practice program developed with funding from the National Cancer Institute and may be implemented by trained volunteers

  15. Technology "Relay Race" Against Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GE Scientists in Technology "Relay Race" Against Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new...

  16. NATURE REVIEWS | GENETICS VOLUME 5 | JUNE 2004 | 405 HIGHLIGHT ADVISORS

    E-Print Network [OSTI]

    OF QUEENSLAND, AUSTRALIA LEONID KRUGLYAK FRED HUTCHINSON CANCER RESEARCH CENTER, USA STANLEY MALOY SAN DIEGO STATE UNIVERSITY, USA BARBARA MEYER UNIVERSITY OF CALIFORNIA, BERKELEY, USA JOHN QUAKENBUSH

  17. Reflections in Mutation Research Electric light causes cancer?

    E-Print Network [OSTI]

    Oliver, Douglas L.

    ]. And on a population level, there is a strong international correlation between estimates of per capita fat consumption dismayed by the recent reports that dietary fat consumption was unrelated to risk of breast cancer in women prospective cohort studies, estimates of fat consumption for individual women and risk to those women

  18. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    late effects of cancer treatments. Retrospective recruitmenteffects associated with cancer treatments. Implications foron the late effects of cancer treatment, due to the growing

  19. Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

  20. CR@B, or `cancer research at Bath', is a network that facilitates interaction between departments and institutes to allow multi-disciplinary activities in the field of cancer

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    CR@B, or `cancer research at Bath', is a network that facilitates interaction between departments and institutes to allow multi-disciplinary activities in the field of cancer research. The network provides groups, promoting opportunities for interdisciplinary research and raising awareness of cancer research

  1. Final Report DOE Grant# DE-FG02-98ER62592: Second Cancers, Tumor p53, and Archaea Research

    SciTech Connect (OSTI)

    Samuel M. Lesko, MD, MPH

    2006-01-14T23:59:59.000Z

    The Northeast Regional Cancer Institute conducted cancer surveillance in Northeast Pennsylvania using data from the instituteâ??s population-based regional cancer registry and the Pennsylvania Cancer Registry. The results of this surveillance have been used to set priorities for research and outreach activities at the Cancer Institute and selected results have been reported to medical professionals at member hospitals and in the community. One consistent observation of this surveillance was that colorectal cancer was unusually common in Northeast Pennsylvania; incidence was approximately 25% higher than the rate published for NCIâ??s Surveillance Epidemiology and End Results (SEER) Program. In addition, death rates form colorectal cancer in several counties in this region were above the 90Th percentile for colorectal cancer mortality in the United States. As a result of these observations, several activities have been developed to increase awareness of colorectal cancer and the value of screening for this cancer in both the lay and medical communities. Funding from this grant also provided support for a population-based study of cancer risk factors, screening practices, and related behaviors. This project continues beyond the termination of the present grant with funding from other sources. This project gathers data from a representative sample of adults residing in a six county area of Northeast Pennsylvania. Analyses conducted to date of the established risk factors for colorectal cancer have not revealed an explanation for the high incidence of this cancer in this population.

  2. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):261–73. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

  3. Use of land surface remotely sensed satellite and airborne data for environmental exposure assessment in cancer research

    E-Print Network [OSTI]

    cancer and environmental contaminants, focusing primarily on agricultural chemical exposure assessmentUse of land surface remotely sensed satellite and airborne data for environmental exposure assessment in cancer research SUSAN K. MAXWELLa , JAYMIE R. MELIKERb AND PIERRE GOOVAERTSc a U.S. Geological

  4. Evotec has teamed up with the Harwell Imaging Partnership (HIP) to maximise the potential of their research into cancer treatment drugs

    E-Print Network [OSTI]

    Zharkova, Valentina V.

    of their research into cancer treatment drugs using the Science and Technology Facilities Council (STFC)'s Central-based cancer treatments work by inhibiting the signals that cause mutated cancer cells to divide and multiply to the treatment. The ability to conduct single-cell imaging of inhibitor drugs binding their target in cancer

  5. Clinical Trials Support -Research Associate II Animal Cancer Center Oncology Clinical Trials Program -Colorado State University Veterinary Teaching Hospital

    E-Print Network [OSTI]

    Stephens, Graeme L.

    Clinical Trials Support - Research Associate II Animal Cancer Center Oncology Clinical Trials Program - Colorado State University Veterinary Teaching Hospital Oncology Clinical Trials Program the daily schedule for the clinical trials rotation o Patient care including, obtaining owner history

  6. Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research

    SciTech Connect (OSTI)

    Subhash Chandra

    2008-05-30T23:59:59.000Z

    The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.

  7. Dalhousie Medical School Cancer Researcher Seeks Biomarkers of Treatment Success HALIFAX,NOVA SCOTIA | CANADA B3H 4H7 | +1 (902) 494-2756

    E-Print Network [OSTI]

    Dellaire, Graham

    Dalhousie Medical School Cancer Researcher Seeks Biomarkers of Treatment Success HALIFAX for monitoring the effectiveness of cancer treatments. "Structures in the nucleus of every cell - known as PML. Their response to cancer therapies could tell us if treatment is working - within 24 hours, instead of weeks," he

  8. SU-D-BRD-03: A Gateway for GPU Computing in Cancer Radiotherapy Research

    SciTech Connect (OSTI)

    Jia, X; Folkerts, M [The University of Texas Southwestern Medical Ctr, Dallas, TX (United States); Shi, F; Yan, H; Yan, Y; Jiang, S [UT Southwestern Medical Center, Dallas, TX (United States); Sivagnanam, S; Majumdar, A [University of California San Diego, La Jolla, CA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Graphics Processing Unit (GPU) has become increasingly important in radiotherapy. However, it is still difficult for general clinical researchers to access GPU codes developed by other researchers, and for developers to objectively benchmark their codes. Moreover, it is quite often to see repeated efforts spent on developing low-quality GPU codes. The goal of this project is to establish an infrastructure for testing GPU codes, cross comparing them, and facilitating code distributions in radiotherapy community. Methods: We developed a system called Gateway for GPU Computing in Cancer Radiotherapy Research (GCR2). A number of GPU codes developed by our group and other developers can be accessed via a web interface. To use the services, researchers first upload their test data or use the standard data provided by our system. Then they can select the GPU device on which the code will be executed. Our system offers all mainstream GPU hardware for code benchmarking purpose. After the code running is complete, the system automatically summarizes and displays the computing results. We also released a SDK to allow the developers to build their own algorithm implementation and submit their binary codes to the system. The submitted code is then systematically benchmarked using a variety of GPU hardware and representative data provided by our system. The developers can also compare their codes with others and generate benchmarking reports. Results: It is found that the developed system is fully functioning. Through a user-friendly web interface, researchers are able to test various GPU codes. Developers also benefit from this platform by comprehensively benchmarking their codes on various GPU platforms and representative clinical data sets. Conclusion: We have developed an open platform allowing the clinical researchers and developers to access the GPUs and GPU codes. This development will facilitate the utilization of GPU in radiation therapy field.

  9. STOMACH CANCER 9. STOMACH CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    of association and strength of evidence Increases risk Decreases risk Convincing or probable Helicobacter pylori/obesity 9 1 Helicobacter and Cancer Collaborative Group, 2001; 2 International Agency for Research on Cancer

  10. Identifying gaps in breast cancer research: Addressing disparities and the roles of the physical and social environment

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    as part of anti- cancer treatment. Eur J Cancer. 2005, 41(status, and breast cancer treatment and survival. J Natlin the receipt of cancer treatment. J Natl Cancer Inst.

  11. Quality of Life Concerns in Young Adult Survivors of Childhood Cancer: A Qualitative Research Investigation

    E-Print Network [OSTI]

    Puckett, Stevie

    2013-06-13T23:59:59.000Z

    systems. Cancer is a term used to signify not just one disease, but over a hundred. The most common types of child cancers include those of the blood or central nervous system, such as leukemia or brain tumors. Together, Acute Lymphocytic Leukemia (ALL... achievement, be labeled as Learning Disabled (LD), or report general problems or difficulties with education and school. Educational difficulties were most evident in survivors of CNS cancers, Leukemia, and Neuroblastoma, which together make up the majority...

  12. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  13. Observational Study Designs for Comparative Effectiveness Research: An Alternative Approach to Close Evidence Gaps in Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Goulart, Bernardo H.L., E-mail: bhg@uw.edu [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Ramsey, Scott D. [Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Hutchinson Institute for Cancer Outcomes Research (HICOR), Seattle, Washington (United States); University of Washington, Seattle, Washington (United States); Parvathaneni, Upendra [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); University of Washington, Seattle, Washington (United States)

    2014-01-01T23:59:59.000Z

    Comparative effectiveness research (CER) has emerged as an approach to improve quality of care and patient outcomes while reducing healthcare costs by providing evidence to guide healthcare decisions. Randomized controlled trials (RCTs) have represented the ideal study design to support treatment decisions in head-and-neck (H and N) cancers. In RCTs, formal chance (randomization) determines treatment allocation, which prevents selection bias from distorting the measure of treatment effects. Despite this advantage, only a minority of patients qualify for inclusion in H and N RCTs, which limits the validity of their results to the broader H and N cancer patient population seen in clinical practice. Randomized controlled trials often do not address other knowledge gaps in the management of H and N cancer, including treatment comparisons for rare types of H and N cancers, monitoring of rare or late toxicity events (eg, osteoradionecrosis), or in some instances an RCT is simply not feasible. Observational studies, or studies in which treatment allocation occurs independently of investigators' choice or randomization, may address several of these gaps in knowledge, thereby complementing the role of RCTs. This critical review discusses how observational CER studies complement RCTs in generating the evidence to inform healthcare decisions and improve the quality of care and outcomes of H and N cancer patients. Review topics include a balanced discussion about the strengths and limitations of both RCT and observational CER study designs; a brief description of design and analytic techniques to handle selection bias in observational studies; examples of observational studies that inform current clinical practices and management of H and N cancers; and suggestions for relevant CER questions that could be addressed by an observational study design.

  14. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  15. Detection and characterization of translational research in cancer and cardiovascular medicine

    E-Print Network [OSTI]

    Cambrosio, Alberto

    Background: Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions ...

  16. Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    complaints after breast cancer treatments: examining the2012). Breast Cancer Research and Treatment 135 Wefel, J.STUDIES OF CANCER AND CANCER TREATMENT Assessment of the

  17. (CANCER RESEARCH 53. I02.VI026. March I. 1993] Benzene and Its Phenolic Metabolites Produce Oxidative DNA Damage in HL60

    E-Print Network [OSTI]

    California at Berkeley, University of

    (CANCER RESEARCH 53. I02.VI026. March I. 1993] Benzene and Its Phenolic Metabolites Produce ABSTRACT Benzene, an important industrial chemical, is myelotoxic and leuke- mogenic in humans effects. Here we report the induction of oxida- tive DNA damage by benzene and its phenolic metabolites

  18. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

  19. Open Access Available online http://breast-cancer-research.com/content/7/6/R1159

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    the efficacy of tamoxifen (Tam) in inhibiting the proliferation of the estrogen dependent MCF-7 cell line Research article Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth to determine the growth inhibitory effect of agents on MCF-7 cells. Dose response interactions between R115

  20. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28T23:59:59.000Z

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  1. BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY

    E-Print Network [OSTI]

    Spence, Harlan Ernest

    BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

  2. Making a difference... A National Cancer

    E-Print Network [OSTI]

    Birmingham, University of

    Making a difference... A National Cancer Research Institute (NCRI) Accredited Trials Unit Contacts Cancer Research UK Clinical Trials Unit School of Cancer Sciences University of Birmingham Edgbaston. Funding The CRCTU receives core funding from Cancer Research UK and has successfully obtained project

  3. Project Sunshine Cancer Research

    E-Print Network [OSTI]

    Crowther, Paul

    to a life-changing opportunity 8 The Student Experience: from libraries to student clubs and societies 9 a sustainable world 15 Who Gives Front cover: Archaeology students archive Sheffield's history. Student Jonathan outcomes. It is also central to sustaining our fundamental values ­ of academic integrity and independence

  4. Contact Details Journeying Beyond Breast Cancer

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

  5. Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.

    E-Print Network [OSTI]

    Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

    2012-01-01T23:59:59.000Z

    Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

  6. Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer

    E-Print Network [OSTI]

    Salzman, Daniel

    Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

  7. Clinical Cancer Care Full screening services and diagnostics

    E-Print Network [OSTI]

    Myers, Lawrence C.

    Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

  8. Nanotechnology in Cancer Treatment and Detection Richard Acosta

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation ·Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

  9. 666 JID 2005:191 (1 March) Gilbert et al. M A J O R A R T I C L E

    E-Print Network [OSTI]

    Gilbert, Peter

    for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington; 2 Vax vaccines containingrecombinant HIV-1 envelope glycoprotein 120 (rgp120) antigens. The first trial (VAX004 November 2004; electronically published 27 January 2005. Reprints or correspondence: Dr. Marc Gurwith, Vax

  10. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    of lung cancer,” Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer,” Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  11. NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 HCIP class.

    E-Print Network [OSTI]

    Cinabro, David

    NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 by March 1st. Apply online! See website for further details. http://hcip.nci.nih.gov The National Cancer (NIH), is the Federal Government's principal agency for cancer research and training. The NCI

  12. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

  13. Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipal Investigators PostdoctoralResearch

  14. LUNG CANCER 6. LUNG CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    LUNG CANCER 47 6. LUNG CANCER 6.1. SUMMARY Lung cancer was the third most common cancer in Ireland (Table 6.1). The average number of new lung cancer cases diagnosed each year was 1,000 in women and 1 for women and 1% for men. The risk of developing lung cancer up to the age of 74 was 1 in 37 for women and 1

  15. Systems Modeling for Prognostic Cancer Biology

    E-Print Network [OSTI]

    Maccabe, Barney

    goal of this research is the development of personalized treatments in cancer, based on the genomic and treatment. A major challenge in contemporary cancer diagnosis and treatment is the development Systems Modeling for Prognostic Cancer Biology Xuefei Wang1 , BaiLian Li2 , Cheryl L. Willman

  16. The Cancer Genome Atlas Pan-Cancer analysis project

    E-Print Network [OSTI]

    Lander, Eric S.

    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

  17. GE Cancer Research | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.Newof EnergyFunding OpportunityF G F ! ( ! ( ! ( ! ( !

  18. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  19. Cancer Cells DOI: 10.1002/anie.201103189

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer · micromachines · nanorobots · nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

  20. lung cancer smoke-free 6 One man's

    E-Print Network [OSTI]

    Roy, Subrata

    Fighting lung cancer Living smoke-free 6 One man's mission85 #12;Cure is the newsletter for the University of Florida Shands Cancer Center, home to cancer care and research for the Southeast's most? For more information about care and services offered at the UF Shands Cancer Center, call 352

  1. SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  2. FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute (UPCI) Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  3. IN A CUREUF HEALTH CANCER CENTER NEWS SPRING 2014

    E-Print Network [OSTI]

    Roy, Subrata

    care and research for the Southeast's most comprehensive academic health center. In each issue, weIN A CUREUF HEALTH CANCER CENTER NEWS Believe SPRING 2014 PAGE6 #12;www.cancer.ufl.eduBelieve in a Cure//Spring 20142 Believe in a Cure is the newsletter for the UF Health Cancer Center, home to cancer

  4. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

  5. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14T23:59:59.000Z

    Breast cancer is the second leading cause of cancer deaths in women with approximately 40,000 patient deaths each year. Theranostics is an emerging area of cancer research in which chemically synthesized molecules are used to simultaneously deliver...

  6. CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

  7. Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary

    SciTech Connect (OSTI)

    Wallner, Paul E., E-mail: pwallner@theabr.org [21st Century Oncology, LLC, and the American Board of Radiology, Bethesda, Maryland (United States); Anscher, Mitchell S. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Barker, Christopher A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Bassetti, Michael [Department of Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin (United States); Bristow, Robert G. [Departments of Radiation Oncology and Medical Biophysics, Princess Margaret Cancer Center/University of Toronto, Toronto, Ontario (Canada); Cha, Yong I. [Department of Radiation Oncology, Norton Cancer Center, Louisville, Kentucky (United States); Dicker, Adam P. [Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Formenti, Silvia C. [Department of Radiation Oncology, New York University, New York, New York (United States); Graves, Edward E. [Departments of Radiation Oncology and Radiology, Stanford University, Stanford, California (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Pennsylvania (United States); Hei, Tom K. [Center for Radiation Research, Columbia University, New York, New York (United States); Kimmelman, Alec C. [Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Kirsch, David G. [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Kozak, Kevin R. [Department of Human Oncology, University of Wisconsin (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan (United States); Marples, Brian [Department of Radiation Oncology, Oakland University, Oakland, California (United States); and others

    2014-01-01T23:59:59.000Z

    In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report.

  8. A Randomized Trial (Irish Clinical Oncology Research Group 97-01) Comparing Short Versus Protracted Neoadjuvant Hormonal Therapy Before Radiotherapy for Localized Prostate Cancer

    SciTech Connect (OSTI)

    Armstrong, John G.; Gillham, Charles M. [Department of Radiation Oncology, St. Luke's Hospital, Dublin (Ireland); Dunne, Mary T., E-mail: mary.dunne@slh.ie [Clinical Trials Resource Unit, St. Luke's Hospital, Dublin (Ireland); Fitzpatrick, David A. [Department of Radiation Oncology, St. Luke's Hospital, Dublin (Ireland); Finn, Marie A.; Cannon, Mairin E. [Clinical Trials Resource Unit, St. Luke's Hospital, Dublin (Ireland); Taylor, Judy C. [Department of Nursing, St. Luke's Hospital, Dublin (Ireland); O'Shea, Carmel M. [Clinical Trials Resource Unit, St. Luke's Hospital, Dublin (Ireland); Buckney, Steven J. [Department of Physics, St. Luke's Hospital, Dublin (Ireland); Thirion, Pierre G. [Department of Radiation Oncology, St. Luke's Hospital, Dublin (Ireland)

    2011-09-01T23:59:59.000Z

    Purpose: To examine the long-term outcomes of a randomized trial comparing short (4 months; Arm 1) and long (8 months; Arm 2) neoadjuvant hormonal therapy before radiotherapy for localized prostate cancer. Methods and Materials: Between 1997 and 2001, 276 patients were enrolled and the data from 261 were analyzed. The stratification risk factors were prostate-specific antigen level >20 ng/mL, Gleason score {>=}7, and Stage T3 or more. The intermediate-risk stratum had one factor and the high-risk stratum had two or more. Staging was done from the bone scan and computed tomography findings. The primary endpoint was biochemical failure-free survival. Results: The median follow-up was 102 months. The overall survival, biochemical failure-free survival. and prostate cancer-specific survival did not differ significantly between the two treatment arms, overall or at 5 years. The cumulative probability of overall survival at 5 years was 90% (range, 87-92%) in Arm 1 and 83% (range, 80-86%) in Arm 2. The biochemical failure-free survival rate at 5 years was 66% (range, 62-71%) in Arm 1 and 63% (range, 58-67%) in Arm 2. Conclusion: No statistically significant difference was found in biochemical failure-free survival between 4 months and 8 months of neoadjuvant hormonal therapy before radiotherapy for localized prostate cancer.

  9. Hidden Process Models Rebecca A. Hutchinson

    E-Print Network [OSTI]

    , and evaluates this framework in the context of fMRI. We provide the HPM formalism, inference and learning of how to visualize the learned mod- els. We conclude that the HPM extensions incorporating domain

  10. STARTLINK COMPOSITE HOUSING J. A. Hutchinson1

    E-Print Network [OSTI]

    Mottram, Toby

    lower embodied energy than a timber frame building, avoids site waste (20-25% of all UK waste friendly and up to 25% cheaper than traditional building. Keywords: Cost, Speed, Energy, Waste, Environment) and reduces shipping and assembly costs because of the light weight. Lightweight houses are easier to build

  11. Hutchinson Utilities Comm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup | OpenHunan Runhua New Energy Development CoHustisford Utilities

  12. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01T23:59:59.000Z

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  13. Putting cancer in focusPathologists key to picking the

    E-Print Network [OSTI]

    Eichman, Brandt F.

    Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

  14. An analysis and hypothesis generation platform for heterogeneous cancer

    E-Print Network [OSTI]

    Reed, Chris

    An analysis and hypothesis generation platform for heterogeneous cancer databases. Philip Roy QUINLAN a,1, Alastair THOMPSON a and Chris REED b a Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee b School of Computing, University of Dundee, Dundee Abstract. The field of cancer research

  15. Hansen Life Sciences Research Building, Room 141 + 201 S. University Street + West Lafayette, IN 47907-2064 (765) 494-9129 + Fax: (765) 494-9193 + www.cancer.purdue.edu

    E-Print Network [OSTI]

    Holland, Jeffrey

    , IN 47907-2064 (765) 494-9129 + Fax: (765) 494-9193 + www.cancer.purdue.edu Acknowledgement of the PURDUE) Institutional Support Grant, it is essential that Cancer Center members acknowledge support from the Purdue for acknowledging the Cancer Center are found below. Acknowledgement of the Center's Shared Resources 1) Methods

  16. angela merkel visits: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researchers Physics Websites Summary: at Avalon Photonics T. Asano Visiting Researcher, Sony Corporation J. Hutchinson Visiting Researcher, Intel of Queensland M. Reddy Post...

  17. analysing repeat visitation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researchers Physics Websites Summary: at Avalon Photonics T. Asano Visiting Researcher, Sony Corporation J. Hutchinson Visiting Researcher, Intel of Queensland M. Reddy Post...

  18. annual dental visits: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researchers Physics Websites Summary: at Avalon Photonics T. Asano Visiting Researcher, Sony Corporation J. Hutchinson Visiting Researcher, Intel of Queensland M. Reddy Post...

  19. Crystallographic Consulting Brings Research to the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at the ALS, with most of his research supporting pharmaceutical companies working on new treatments for metabolic diseases and cancer. Pauly spent 15 years of his career working...

  20. ORISE: Graduate Student Research Experiences - Folami Alamudun

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the Research Alliance Math and Science Program at ORNL, analyzing the visual scanning pattern radiologists use to detect cancer in mammograms. His goal is to help increase...

  1. Final Report for research grant entitled "Development of Reagents for Application of At-211 and Bi-213 to Targeted Radiotherapy of Cancer"

    SciTech Connect (OSTI)

    Wilbur, D. Scott

    2011-12-23T23:59:59.000Z

    This grant was a one-year extension of another grant with the same title (DE-FG03-98ER62572). The objective of the studies was to continue in vivo evaluation of reagents to determine which changes in structure were most favorable for in vivo use. The focus of our studies was development and optimization of reagents for pretargeting alpha-emitting radionuclides At-211 or Bi-213 to cancer cells. Testing of the reagents was conducted in vitro and in animal model systems. During the funding period, all three specific aims set out in the proposed studies were worked on, and some additional studies directed at development of a method for direct labeling of proteins with At-211 were investigated. We evaluated reagents in two different approaches in 'two step' pretargeting protocols. These approaches are: (1) delivery of the radionuclide on recombinant streptavidin to bind with pretargeted biotinylated monoclonal antibody (mAb), and alternatively, (2) delivery of the radionuclide on a biotin derivative to bind with pretargeted antibody-streptavidin conjugates. The two approaches were investigated as it was unclear which will be superior for the short half-lived alpha-emitting radionuclides.

  2. RESEARCH ARTICLE Open Access The effect of patient characteristics on second

    E-Print Network [OSTI]

    Boyer, Edmond

    of cancer survival due to more frequent early detection and advances in cancer treatments, the cancerRESEARCH ARTICLE Open Access The effect of patient characteristics on second primary cancer risk11,14 , Anne-Sophie Woronoff12,14 and Michel Velten1,2,13,14 Abstract Background: Although cancer

  3. Dana-Farber Cancer Institute About Dana-Farber Cancer Institute

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    ;About the Jimmy Fund The Jimmy Fund raises vital funds to support adult and pediatric cancer care and research at Dana-Farber exclusively. Since 1948, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: · raised more than $948

  4. 1 888 939 3333 | cancer.ca Cancer Statistics

    E-Print Network [OSTI]

    Habib, Ayman

    1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

  5. Strong Memorial Hospital Cancer Committee Report 2 2011 Strong Memorial Hospital Cancer Registry Report

    E-Print Network [OSTI]

    Goldman, Steven A.

    's two largest cancer research facilities could result in a scientific powerhouse, enhancing faculty patients.This accounts for an accrual rate of 16.9 percent using the 2010 registry data for total number

  6. Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

    E-Print Network [OSTI]

    Zhang, GuangJun

    The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we ...

  7. 12University Research Priority Programs

    E-Print Network [OSTI]

    Zürich, Universität

    12University Research Priority Programs Asia and Europe Dynamics of Healthy Aging Ethics Evolution Market Regulation Social Networks Language and Space Systems Biology/Functional Genomics Translational Cancer Research Solar Light to Chemical Energy Conversion #12;Contact Dr. Cornelia Schauz Research

  8. Focus on the Physics of Cancer

    E-Print Network [OSTI]

    Risler, Thomas

    2015-01-01T23:59:59.000Z

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  9. This Masters in Cancer Sciences* will prepare you for a career in cancer science, whether you aim to pursue a PhD or further medical studies, or seek a career in the health services

    E-Print Network [OSTI]

    Guo, Zaoyang

    This Masters in Cancer Sciences* will prepare you for a career in cancer science, whether you aim, pathology and clinical science. Each week is focused around one of the new Hallmarks of Cancer research into the fundamental principles of cancer cell biology can translate to advances in the diagnosis

  10. CANCER BIOLOGY Infectioustumourcells

    E-Print Network [OSTI]

    Nowak, Martin A.

    CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

  11. New Directions and Approached to Cancer Treatment: Dr Mike Partridge

    E-Print Network [OSTI]

    New Directions and Approached to Cancer Treatment: Imaging Dr Mike Partridge STFC Workshop, Birmingham, 28th January 2010 Joint Department of Physics The Institute of Cancer Research / The Royal to treatment to determine anatomical targets and organs-at-risk. · A clear next step is to use biological

  12. The use of polarized light for skin cancer detecton

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01T23:59:59.000Z

    and subsequent biopsy of suspicious lesions. Many cancerous lesions are missed and many benign lesions are biopsied using these techniques. This process is painful and expensive. The proposed research is driven by the need for a non-invasive skin cancer...

  13. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    ScienceCinema (OSTI)

    Gray, Joe

    2013-05-29T23:59:59.000Z

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  14. Bonus-- Cameras Designed To Strengthen Nuclear Security Can Also Detect Cancer

    Broader source: Energy.gov [DOE]

    Thanks to researchers from Brookhaven National Laboratory, a high-resolution gamma camera exists that can be used to detect prostate cancer.

  15. Simulating the Hallmarks of Cancer Robert G. Abbott Sandia National Laboratories

    E-Print Network [OSTI]

    Forrest, Stephanie

    controlled and longevity climbs in developing nations. Although the need for better cancer treatment slow, and treatments are generally limited to specific forms of the disease. Most cancer researchSimulating the Hallmarks of Cancer Robert G. Abbott Sandia National Laboratories P.O. Box 5800

  16. Modeling Cancer Progression via Pathway Dependencies Elena Edelman1,2

    E-Print Network [OSTI]

    West, Mike

    Modeling Cancer Progression via Pathway Dependencies Elena Edelman1,2 , Justin Guinney1,2 , Jen Cancer Research Foundation Clinical Investigation, NCI R01 CA125618-01, and NSF DMS 0732260. * To whom correspondence should be addressed. Email: sayan@stat.duke.edu Abstract Cancer is a heterogeneous disease often

  17. Colon Cancer Mapping | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced. C o w l i tCollaboration March 16,

  18. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials FindAdvanced MaterialsDepartment of EnergyScience

  19. A Quarterly Publication Featuring Achievements from Northwestern University Research Centers CenterPiece

    E-Print Network [OSTI]

    Shahriar, Selim

    research to prevent cancer, detect it earlier, and develop more effective treatments. Vimla Band, medicine, and Hamid Band, medicine, lend international stature to ENH's growing cancer and medical genetics to cancer. Vimla Band's focus is the molecular basis of tumor progression with emphasis on breast cancer

  20. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Colorectal cancer Colorectal cancer Colorectal

    E-Print Network [OSTI]

    Paxton, Anthony T.

    explain the higher US survival rate. Aggressive treatment may also be a factor. 5. Colorectal cancer Risks--22000000 28 Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Col orectal cancer Colorectal cancer Colorectal ca ncer Colorectal cancer Colorectal cancer Color ectal cancer

  1. RESEARCH ARTICLE Open Access Occupational exposure to asbestos and lung

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH ARTICLE Open Access Occupational exposure to asbestos and lung cancer in men: evidence consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. Self

  2. Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis

    E-Print Network [OSTI]

    Connor, Yamicia Doyasi

    2013-01-01T23:59:59.000Z

    Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...

  3. Analysis of alterations in the human cancer genome

    E-Print Network [OSTI]

    Carter, Scott L. (Scott Lambert)

    2011-01-01T23:59:59.000Z

    Aneuploidy, an abnormal complement of chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer ...

  4. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  5. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  6. SYN T H E S I S THE MAGAZINE OF UC DAVIS CANCER CENTER VOL 14 NO 2 FALL/WINTER 2011

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    to cancer diagnosis, treatment and survivorship: adolescents and young adults (AYA). Although cancer Connections 8 National research team tries new approach to speed treatments First steps 10 Cancer CenterSYN T H E S I S THE MAGAZINE OF UC DAVIS CANCER CENTER VOL 14 · NO 2 · FALL/WINTER 2011 Younger

  7. NATIONAL PRESS RELEASE I PARIS I 18 NOVEMBER 2013 Cancer chronotherapy consists in administering treatment at an optimal time. Because the

    E-Print Network [OSTI]

    Canet, Léonie

    towards personalized chronotherapy treatments. In an article published in the journal Cancer Research studied the toxicity of irinotecan, an anti-cancer drug widely used in the treatment of cancer NATIONAL PRESS RELEASE I PARIS I 18 NOVEMBER 2013 Cancer chronotherapy consists

  8. Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    following breast cancer treatment. Cancer Epidemiollymphedema after breast cancer treatment. Cancer Epidemiolfollowing breast cancer treatment. Clin Cancer Res 18: 232–

  9. RESEARCH REPORT 2012 ResearchResearchResearch

    E-Print Network [OSTI]

    Saldin, Dilano

    research on batteries and energy storage, and are part of a multimillion- dollar investment by Johnson Controls that aims to make Wisconsin a hub for energy-storage technology. #12;Chancellor's Welcome A great powerful UW-MILWAUKEE RESEARCH REPORT 2012 As Wisconsin's premier public urban institution, the University

  10. http://vetmed.tamu.edu/graduate New CVM ReseaRCh FaCilities

    E-Print Network [OSTI]

    many exciting research opportunities for the college. · The Diagnostic Imaging and Cancer Treatment and human treatments for cancer and other diseases. Annual Report Fiscal Year 2010­2011 Research in the Treatment of Triple-Negative and ErbB2-Positive Breast Cancer" TAMU will serve as a mentoring institution

  11. Custom Search New Tool for Next-Generation Cancer Treatments using Nanodiamonds

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Custom Search New Tool for Next-Generation Cancer Treatments using Nanodiamonds A research team be used both as a research tool in the development of next-generation cancer treatments and as a nanomanufacturing tool to build the implantable drug delivery devices that will apply these treatments

  12. Impact of Pelvic Radiotherapy on Gut Microbiota of Gynecological Cancer Patients Revealed by Massive

    E-Print Network [OSTI]

    Bae, Jin-Woo

    , Republic of Korea, 2 Fermentation and Functionality Research Group, Korea Food Research Institute, Sungnam University, Seoul, Republic of Korea Abstract Although pelvic irradiation is effective for the treatment. Introduction More than 50% of cancer patients receive irradiation for cancer treatment [1]. Pelvic irradiation

  13. Page 2 Innovative Clinical Trials and Research Expand Targeted Medical Therapies and Personalized Approaches to Lung

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    and changing the standard of care for many patients with thoracic cancers; · Offers a wide range of cutting-edge factor receptor (EGFR) mutations in non-small cell lung cancer, medical oncologists and researchers

  14. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01T23:59:59.000Z

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  15. Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

  16. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01T23:59:59.000Z

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  17. Skin metastases from lung cancer

    E-Print Network [OSTI]

    Mollet, Todd W; Garcia, Carlos A; Koester, Glenn

    2009-01-01T23:59:59.000Z

    cutaneous metastases from the lung frequently indicate aof skin metastases from lung cancer. Intern Med. 1996; 35:9. Coslett LM, Katlic MR. Lung cancer with skin metastasis.

  18. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M [Los Alamos National Laboratory

    2012-07-26T23:59:59.000Z

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  19. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  20. RESEARCH SUMMARY DAVID WILLIAM KNOWLES

    E-Print Network [OSTI]

    Knowles, David William

    plays a determining role in the treatment decision. Unfortunately, the risk associated with benign is to aid the treatment decision process of breast cancer patients by providing pathologists with new tools@lbl.gov http://dwknowles.lbl.gov/ Research Interests: My laboratory develops statistical, image analysis

  1. Lung cancer...115 Chapter 11

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NICR/NCRI Lung cancer...115 Chapter 11: Lung cancer (including trachea, bronchus and lung; C33-C34 of lung cancer diagnosed each year in Ireland during 2000-2004. o Male incidence rates decreased by 1 by 2.7%. o Higher levels of treatment occurred among those with small cell lung cancer (compared to non

  2. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  3. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    Alternative Medicine in Cancer Treatment. (2012). Retrievedcancertopics/pdq/cam/cam-cancer-treatment/patient/page2 8.and alternative (CAM) cancer treatments in use, including

  4. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01T23:59:59.000Z

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  5. ORIGINAL ARTICLE Lipocalin 2 is required for BCR-ABL-induced tumorigenesis

    E-Print Network [OSTI]

    Strong, Roland K.

    Technology (ERAYO), Japan Science and Technology Corporation, Osaka, Japan and 7 Fred Hutchinson Cancer and marrow of mice, leading to early death in contrast to parental K562 or K562 clone (C6) expressing low

  6. Original Message Subject: Change in unit assignments for research administrators effective September 10th

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Neurology Obstetrics, Gynecology and Reproductive Sciences Northeast Sustainable Agriculture Research of Education and Social Services Vermont Cancer Center Libraries Dana Medical Library Microbiology

  7. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  8. Science Centric -Science, health and technology, breaking news [PDA version] New tool for next-generation cancer treatments using nanodiamonds

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    for next-generation cancer treatments using nanodiamonds Science Centric | 19 May 2009 15:50 GMT A research be used both as a research tool in the development of next-generation cancer treatments and as a nanomanufacturing tool to build the implantable drug delivery devices that will apply these treatments

  9. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    (Aerospace Systems, Chemical Systems, Digital Electronic Systems, Electromechanical Control Systems) Number 106 Intro To World Religions 3 HA 261 Intro to Modern Art 3 AR 102 History of Modern Art 3 PHIL 140

  10. Dallam Sherman Hansford Ochiltree Lipscomb Hartley Hutchinson Roberts Hemphill

    E-Print Network [OSTI]

    Baylor Wilbarger Wichita Archer Kent Stonewall Haskell Throckmorton Young Stephens Clay Jack Montague Tom Green Concho Schleicher Val Verde Menard McCulloch Mason Llano San Saba Mills Lampasas Burnet West

  11. Hutchinson County, South Dakota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°, -97.6982272°

  12. Hutchinson County, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°,

  13. South Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt LtdShawangunk, NewSingaporeSonix JapanCalifornia: EnergyHuntington, New

  14. Colorectal cancer and diet in Scotland 

    E-Print Network [OSTI]

    Theodoratou, Evropi

    2008-01-01T23:59:59.000Z

    Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

  15. DNA "Nano-Claw": Logic-Based Autonomous Cancer Targeting and Mingxu You,,

    E-Print Network [OSTI]

    Tan, Weihong

    DNA "Nano-Claw": Logic-Based Autonomous Cancer Targeting and Therapy Mingxu You,, Lu Peng, Na Shao for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute a DNA- based device, called "Nano-Claw". Combining the special structure-switching properties of DNA

  16. The association between fatalistic beliefs and late stage at diagnosis of lung and colorectal cancer

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios; Liu, Michael Pang-Hsiang; Abel, Gary A.; Wardle, Jane; Keating, Nancy L.

    2015-02-03T23:59:59.000Z

    -based cohort of 4,319 U.S. patients with newly-diagnosed lung or colorectal cancer participating in the Cancer Care Outcomes and Research Surveillance (CanCORS) study. Fatalistic beliefs were assessed with an established measure. A fatalism score (range 4...

  17. Documenting the Financial Impact of a New Cancer Clinical Trials Network and the

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Documenting the Financial Impact of a New Cancer Clinical Trials Network and the Out and Economic Research. Documenting the Financial Impact of a New Cancer Clinical Trials Network and the Out.D. Department of Health Policy and Management University of Kansas Medical Center tgurley

  18. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    , abbreviated as CRC) is the second leading cause of cancer-related deaths in the United States for both men to lung cancer in cause of cancer deaths. Despite the fact that it is highly preventable, approximately, colorectal cancer is the third most common cause of death from cancer in women (after breast and lung cancer

  19. RESEARCH ARTICLE Open Access Vaccination with human anti-trastuzumab

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    viability of SK-OV-3 cells, a HER2-positive cancer cell line, in nude mice. MMTV.f.huHER2(Fo5) transgenicRESEARCH ARTICLE Open Access Vaccination with human anti-trastuzumab anti-idiotype scFv reverses relapses in HER2-expressing breast cancer. Here, we tested whether trastuzumab-selected single-chain Fv (sc

  20. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29T23:59:59.000Z

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  1. In vivo generation of 'vaccination nodes' using injectable alginate hydrogels for cancer immunotherapy

    E-Print Network [OSTI]

    Hori, Yuki

    2009-01-01T23:59:59.000Z

    Despite the amount of ongoing intensive research, tumor cells have continued to outwit us in the effort to combat and prevent cancer by exerting a number of mechanisms to evade and suppress anti-tumor immune responses. The ...

  2. anti-cancer agent combining: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ASP and Planning, Jul-Aug 2003, Sydney, NICTA Third week (Chapter 4) The second part Zachmann, Gabriel 3 Anti-Cancer Drugs 1998, 9, pp. 525-530 Research paper Engineering Websites...

  3. Hindawi Publishing Corporation Prostate Cancer

    E-Print Network [OSTI]

    Ahn, Hongshik

    Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

  4. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  5. Pomegranate Juice and Pomegranate Derived Natural Products as Alternative Treatment for Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Wang, Lei

    2013-01-01T23:59:59.000Z

    prostate cancer. Cancer Treatment Reviews 36, Sternlicht,prostate cancer. Cancer Treatment Reviews 36, Steiner, H. ,prostate cancer. Cancer Treatment Reviews 36, Sureban,

  6. STRUCTURAL SYSTEMS RESEARCH PROJECT August 25, 2011 Page 1 of 11

    E-Print Network [OSTI]

    Fainman, Yeshaiahu

    Standard for Seismic Design of Cold-Formed Steel Structures: Special Bolted Moment Frames," A. Sato, C of Floor and Wall Mounted Mechanical and Electrical Equipment in Buildings," D.A. Watkins, L. Chiu, T-Loaded Reinforced Concrete Walls," T. Soppe, T.C. Hutchinson SSRP -09/06 "Health Monitoring To Detect Failure

  7. Rethinking diagnostic delay in cancer: how difficult is the diagnosis?

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios; Wardle, Jane; Rubin, Greg

    2014-12-10T23:59:59.000Z

    for Health Services Research, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK; 2Health Behaviour Research Centre, University College London, London, UK; 3School of Medicine, Pharmacy and Health, University... U. Evaluation of risk assessment tools for suspected cancer in general practice: a cohort study. Br J Gen Pract 2013;63:e30-6. 23 Guldbrandt LM, Rasmussen TR, Rasmussen F, Vedsted P. Implementing direct access to low-dose computed tomography...

  8. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

  9. Research Statement

    E-Print Network [OSTI]

    2015-01-18T23:59:59.000Z

    entries in the natural numbers, into an undergraduate research project. ..... and developing the undergraduate research project described at the end of Section 2,

  10. Prognosis of Breast Cancer using Genetic Programming

    E-Print Network [OSTI]

    Ludwig, Simone

    diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their kind of cancer. Therefore, it is important to identify the type of cancer accurately, so that the correct treatment can be started. Breast cancer is a cancer that starts

  11. Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

    2011-10-04T23:59:59.000Z

    In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

  12. Cooperative Institutional Research Program

    E-Print Network [OSTI]

    Baltisberger, Jay H.

    (speech, sight, mobility, hearing, etc.) Chronic illness (cancer, diabetes, autoimmune disorders, etc

  13. Estimating radiogenic cancer risks

    SciTech Connect (OSTI)

    NONE

    1994-06-01T23:59:59.000Z

    This document presents a revised methodology for EPA`s estimation of cancer risks due to low-LET radiation exposures in light of information that has become available since the publication of BIER III, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model is one in which the age-specific relative risk coefficients are obtained by taking the geometric mean of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks from Japan to the U.S. (multiplicative and NIH projection methods). Using 1980 U.S. vital statistics, the risk models are applied to estimate organ-specific risks, per unit dose, for a stationary population.

  14. Modeling Prostate Cancer Detection Probability, with Applications

    E-Print Network [OSTI]

    Serfling, Robert

    investigating causes and treatments. Robert Serfling Modeling Prostate Cancer Detection Probability cancer present as well as tumor nodule sizes, to judge clinical significance before treatment selectionModeling Prostate Cancer Detection Probability, with Applications Robert Serfling1 University

  15. Erysipelas after breast cancer treatment (26 cases)

    E-Print Network [OSTI]

    2005-01-01T23:59:59.000Z

    Erysipelas after breast cancer treatment. Tunis Med, 2002 ,after breast cancer treatment (26 cases) A Masmoudi 1 , Iof 5.23 years after cancer treatment (3 months to 15 years)

  16. Could You Cure Cancer? Alastair M Thompson

    E-Print Network [OSTI]

    Greenaway, Alan

    Could You Cure Cancer? Alastair M Thompson Professor of Surgical Oncology, University of Dundee a.m.thompson ............................could YOU cure cancer? Some questions on cancer: #12;a.m.thompson @ dundee.ac.uk #12;

  17. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

  18. Diet, MicroRNAs and Prostate Cancer

    E-Print Network [OSTI]

    Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

    2010-01-01T23:59:59.000Z

    deregulation in human cancer. Cell Cycle. 2008;7:2643–6. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

  19. Childhood Cancer Tracking Initiative in Massachusetts

    E-Print Network [OSTI]

    Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

  20. Postdoctoral Research Awards Annual Research Meeting: Joseph...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Joseph Mondloch Postdoctoral Research Awards Annual Research Meeting: Joseph Mondloch Postdoctoral Research Awards Annual Research Meeting: Joseph Mondloch poster presentation....

  1. Scott T. Retterer Nanofabrication Research Laboratory

    E-Print Network [OSTI]

    Pennycook, Steve

    -Tie Company Inc., Addison, IL 1998­1999 Undergraduate Research Assistant, University of Illinois­Chicago 1997 Technologies, Emerging 2008­2009 Technologies, Cancer Sample Preparation 2003­2005 Biomedical Engineering of controlling the flow of materials, information and energy within and between biological systems

  2. Mathematical Toolkit Unlocks Some Cancer Secrets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

  3. Microbiological Research ] (

    E-Print Network [OSTI]

    Sims, Gerald K.

    ) or to expand on previous research addressing the fate of nitrogen from agrochemicals (Bichat et al., 1999

  4. Breakthrough: Fighting Cancer with Nanoparticles

    ScienceCinema (OSTI)

    Rozhkova, Elena

    2013-04-19T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  5. Breakthrough: Fighting Cancer with Nanoparticles

    SciTech Connect (OSTI)

    Rozhkova, Elena

    2012-01-01T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  6. The development of a sensitive method to study volatile organic compounds in gaseous emissions of lung cancer cell lines 

    E-Print Network [OSTI]

    Maroly, Anupam

    2005-08-29T23:59:59.000Z

    The ultimate objective of this research was to develop a low cost, reliable system that would lead to early detection of lung cancer. Tests involved the quantitation of gaseous metabolic emissions from immortalized lung ...

  7. Inhibitory actions of Ah receptor agonists and indole-containing compounds in breast cancer cell lines and mouse models 

    E-Print Network [OSTI]

    Walker, Kelcey Manae Becker

    2005-08-29T23:59:59.000Z

    The aryl hydrocarbon receptor (AhR) binds synthetic and chemoprotective phytochemicals, and research in this laboratory has developed selective AhR modulators (SAhRMs) for treatment of breast cancer. Activation of the AhR ...

  8. Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

    E-Print Network [OSTI]

    Silva, Ana-Luisa; Dawson, Sarah N.; Arends, Mark J.; Guttula, Kiran; Hall, Nigel; Cameron, Ewen A.; Huang, Tim H.-M.; Brenton, James D.; Tavaré, Simon; Bienz, Mariann; Ibrahim, Ashraf E. K.

    2014-11-29T23:59:59.000Z

    (funded through the NIHR Biomedical Research Centre) for their help with this work. A.L.S. was supported by the Fundacao para a Ciencia e Tecnologia (Portugal); A.I. by a Clinician Scientist Fellowship from Cancer Research UK (grant no C10112/A11388); M...

  9. EDUCATION, RESEARCH AND INNOVATION Lund University / Presentation 2011

    E-Print Network [OSTI]

    / Presentation 2011 MAX IV & the European Spallation Source #12;Lund University / Presentation 2011 World to be completed in 2015 ESS · Based on the world's most powerful neutron source · Will be used to study/innovation) MAX IV · World-leading research Centre for cancer research · Access to the premises at the latest 28

  10. Cancer Immunol Immunother . Author manuscript Anti-HER2 vaccines: new prospects for breast cancer therapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Immunol Immunother . Author manuscript Page /1 18 Anti-HER2 vaccines: new prospects for breast cancer therapy Maha Zohra Ladjemi 1 , William Jacot 2 , Thierry Chard sè 1 , Andr P legriné è 1 cancer accounts for more than 400.000 new cancer cases and more than 130.000 cancer deaths in Europe

  11. Skin cancer is the most com-mon form of cancer in the United

    E-Print Network [OSTI]

    Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

  12. NON-MELANOMA SKIN CANCER 3. NON-MELANOMA SKIN CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NON-MELANOMA SKIN CANCER 21 3. NON-MELANOMA SKIN CANCER 3.1. SUMMARY Non-melanoma skin cancer (NMSC their cancer diagnosis. Table 3.1 Summary information for non-melanoma skin cancer in Ireland, 1995 number of cases for both sexes presented in the 70­79 age group. Figure 3.1 Age distribution of non-melanoma

  13. Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium

    SciTech Connect (OSTI)

    Ellis, Matthew; Gillette, Michael; Carr, Steven A.; Paulovich, Amanda G.; Smith, Richard D.; Rodland, Karin D.; Townsend, Reid; Kinsinger, Christopher; Mesri, Mehdi; Rodriguez, Henry; Liebler, Daniel

    2013-10-03T23:59:59.000Z

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verifi cation using targeted mass spectrometry methods.

  14. Re-organisation of oesophago-gastric cancer care in England: progress and remaining challenges

    E-Print Network [OSTI]

    Palser, Tom R; Cromwell, David A; Hardwick, Richard H; Riley, Stuart A; Greenaway, Kimberley; Allum, William; van der Meulen, Jan HP

    2009-11-12T23:59:59.000Z

    for Cancer Services London: Her Maj- esty's Stationary Office; 2004. 11. The Royal College of Radiologists: Good Practice Guide for Clinical Oncologists 2nd edition. London: The Royal College of Radiologists; 2003. 12. National Cancer Action Team: National... Research 2009, 9:204 http://www.biomedcentral.com/1472-6963/9/204 their surgical inpatients and 41 (33%) did not perform any formal nutritional assessment before starting treat- ment. Discussion Since the publication of the Improving Outcomes Guid- ance [5...

  15. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Sehl, Mary; Zhou, Hua; Sinsheimer, Janet; Lange, Kenneth

    2009-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  16. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Mary Sehl; Hua Zhou; Janet S. Sinsheimer; Kenneth L. Lange

    2011-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  17. Also in This Issue 2 International Cancer

    E-Print Network [OSTI]

    Müller, Jens-Dominik

    Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

  18. CANCER RISKS AM I AT RISK?

    E-Print Network [OSTI]

    Hardy, Christopher R.

    CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

  19. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  20. Research Gallery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Monitoring and Research Nanotechnology: The Science of the Small Algae to Biofuels: Squeezing Power from Pond Scum Living with Wildfire: A Shared Community...

  1. AnnualReportofResearchActivity Total research expenditures, 1989 to 1999, in millions of dollars.

    E-Print Network [OSTI]

    Lee, Dongwon

    products, safer food supplies, greater understanding of disease, a more modern national defense heart. Other research programs focus on Alzheimer's disease, AIDS treatment and prevention, cancer inspired by programs undertaken in the arts and culture that stimulate heritage tourism, sustain folklore

  2. What's Trending in Breathlessness Research? Proceedings of the 8th Annual Meeting of the Breathlessness Research Interest Group

    E-Print Network [OSTI]

    Chin, C. A.; Butcher, H. Holt; Ryan, R.; Johnson, M.; Pattinson, K.; Currow, D.; Banzett, R.; Yorke, J.; Clayson, H.; Macnaughton, J.; Penfold, C.; Farquhar, M.; Booth, S.

    2015-01-01T23:59:59.000Z

    learning points already including the importance of understanding cultural differences and how these affect research. Presentation 5 Developing a complex non-pharmacological intervention for the respiratory symptom cluster of breathlessness, cough... and fatigue in lung cancer Dr Janelle Yorke In lung cancer, the respiratory distress symptom cluster of breathlessness, cough and fatigue has been described by Molassiotis et al with breathlessness usually being the driving symptom of the cluster.24...

  3. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    weight after breast cancer treatments: evidence from thestatus), breast cancer treatment history (years sinceto follow less aggressive cancer treatments 33-37 associated

  4. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    of the primary breast cancer and treatments received overallof the primary cancer and treatments received, only twoduring and after cancer treatment: a guide for informed

  5. Feeding Frenzy: Shark Cartilage as Treatment for Cancer

    E-Print Network [OSTI]

    Saben, Jamie

    1997-01-01T23:59:59.000Z

    Over Shark Cartilage as Cancer Treatment." Journal of thewith shark cartilage as cancer treatment and are especiallyshark cartilage as a cancer treatment, assess the public's

  6. Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer

    E-Print Network [OSTI]

    Aliu, Sheye

    2009-01-01T23:59:59.000Z

    2.9 Breast Cancer Treatment . . . . . . . 2.9.1. Localassessing antivascular cancer treatments. Br J Radiol, 2003.imaging, for breast cancer treatment monitoring. To achieve

  7. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01T23:59:59.000Z

    Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

  8. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01T23:59:59.000Z

    receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

  9. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    cigarette smoking, and the risk of breast cancer. Cancerand breast cancer risk. JAMA Ambrosone, C.B. , Kropp, S. ,genotypes, and breast cancer risk: pooled analysis and meta-

  10. Technology in Cancer Research and Treatment ISSN 1533-0346

    E-Print Network [OSTI]

    Piao, Daqing

    could monitor changes of the hemoglobin oxygen saturation (StO2) in addition to those of the total. Canine transmissible venereal tumor (TVT) cells were injected into the right lobe of a dog's prostate and Computer Engineering, Oklahoma State University, Stillwater, OK, USA 2 Department of Veterinary Clinical

  11. Technology in Cancer Research and Treatment ISSN 1533-0346

    E-Print Network [OSTI]

    Fessler, Jeffrey A.

    ) ©Adenine Press (2006) Dual Energy CT Attenuation Correction Methods for Quantitative Assessment of Response classification/scaling algorithm and a model-based dual-energy CT method that incorpo- rates the polyenergetic imaging of high atomic number ma- terials can be achieved by combining low-dose x-ray imaging with dual

  12. Technology in Cancer Research & Treatment ISSN 1533-0346

    E-Print Network [OSTI]

    Wang, Lihong

    on the measurement of ultrasonic waves induced by electromagnetic pulses, can reveal dielectric or optical properties. Electromagnetic energy is absorbed by biological tissues when an electromag- netic pulse, such as a microwave or laser pulse, is used to irradiate the tissues. Absorption of the electromagnetic energy generates heat

  13. [CANCER RESEARCH 61, 57105713, August 1, 2001] Advances in Brief

    E-Print Network [OSTI]

    Brenner, David Jonathan

    to Radiation Oncogenesis in ATM Heterozygous versus Wild-Type Mammalian Cells1 Lubomir B. Smilenov,2 David J

  14. DOE Research Contributions to Radiation and Cancer Therapy

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Garyand TechnicalAboutContact Us Contact UsOffice ofofand

  15. Ribosome research in atomic detail offers potential insights into cancer,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources Resources About1 Sign In AboutReversinganemia,

  16. Research Sheds Light on Workings of Anti-cancer Drug

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s oPrecipitationWeatherTacklingAboutNRAP: Air,Naturalm

  17. Insight into Alzheimer's, cancer, anemia gleaned from ribosome research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn Other NewsSpin and Frame ofHow

  18. World Cancer Day 2015: Not Beyond Us | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsingWhat isJoin the ChallengeHistoryWorkshopWorkshopsWorld

  19. Researchers, Appointments

    E-Print Network [OSTI]

    in Aviation Gas Turbine Combustion/Emissions Research and Design System Optimization (UTIAS) Luca ScardoviInnovative Researchers, Devoted Educators Academic Appointments 2009­2012 #12;Innovative is a centre of immense inspiration, remarkable innovation and endless possibilities. And since 2009, we have

  20. Postdoctoral Research Awards Annual Research Meeting: Padmaja...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Padmaja Gunda Postdoctoral Research Awards Annual Research Meeting: Padmaja Gunda Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  1. Postdoctoral Research Awards Annual Research Meeting: Brandon...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Brandon Mercado Postdoctoral Research Awards Annual Research Meeting: Brandon Mercado Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from...

  2. Research | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear Press ReleasesIn the Inorganic PV thrust,ResearchResearch

  3. AR Researchers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for fixed-wing unmanned aerial vehicles with an emphasis in cooperative unmanned vehicle research and intelligent remote sensing. Cal Christensen, M.S., P.E., P.M.P Cal...

  4. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01T23:59:59.000Z

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  5. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01T23:59:59.000Z

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  6. Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

    E-Print Network [OSTI]

    Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

    2011-05-28T23:59:59.000Z

    Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

  7. RADIATION RESEARCH 151, 225-229 (1999) 0033-7587199 $5.00

    E-Print Network [OSTI]

    Brenner, David Jonathan

    1999-01-01T23:59:59.000Z

    Society INTRODUCTION One of the most important issues in radiation protection is the effect of doseRADIATION RESEARCH 151, 225-229 (1999) 0033-7587199 $5.00 0 1999 by Radiation Research Society of Breast Cancer Induced by Low-LET Radiation? D. J. Brenner Centerfor Radiological Research, Columbia

  8. Cancer Epidemiol Biomarkers Prev. Author manuscript Diet, cancer, and the lipidome

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Epidemiol Biomarkers Prev. Author manuscript Page /1 8 Diet, cancer, and the lipidome Bougnoux Philippe 1 * , Giraudeau Bruno 2 , Couet Charles 1 Nutrition, Croissance et Cancer1 INSERM : E211 with the development of breast cancer by delaying its occurrence makes identification of defined molecules a mandatory

  9. Seminars in Cancer Biology 15 (2005) 484493 Dynamics of colorectal cancer

    E-Print Network [OSTI]

    Nowak, Martin A.

    Seminars in Cancer Biology 15 (2005) 484­493 Review Dynamics of colorectal cancer Franziska Michora Abstract Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main

  10. Mabs against Pancreatic cancer Therapeutic antibodies for the treatment of pancreatic cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mabs against Pancreatic cancer 1 Therapeutic antibodies for the treatment of pancreatic cancer pancreatic cancer inserm-00497886,version1-6Jul2010 Author manuscript, published in "TheScientificWorldJournal (electronic resource) 2010;10:1107-20" DOI : 10.1100/tsw.2010.103 #12;Mabs against Pancreatic cancer 2

  11. Do cancer cells undergo phenotypic switching? The case for imperfect cancer

    E-Print Network [OSTI]

    De Cindio, Fiorella

    Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers Celoria 26, 20133 Milano, Italy. The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations

  12. Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer

    E-Print Network [OSTI]

    Greenaway, Alan

    Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

  13. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  14. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    cancer cells MCF-7 and MDA- MB-231. Biomed. Pharmacother.and prevents apoptosis in MDA-MB-231 breast cancer cells. J.Gaithersburg, MD). Cell Culture MDA-MB-468, MDA-MB-435, ZR-

  15. Lgr4 in Breast Cancer Stem Cells

    E-Print Network [OSTI]

    Zeng, Li

    2014-12-11T23:59:59.000Z

    Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, and activate intracellular...

  16. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31T23:59:59.000Z

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  17. Cancer Vulnerabilities Unveiled by Genomic Loss

    E-Print Network [OSTI]

    Nijhawan, Deepak

    Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...

  18. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel S. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stratton, Kayla L. [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States)] [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States); Smith, Susan A.; Weathers, Rita [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hammond, Sue [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States)] [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States); Mertens, Ann C. [Department of Pediatrics, Emory University, Atlanta, Georgia (United States)] [Department of Pediatrics, Emory University, Atlanta, Georgia (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)] [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States); Armstrong, Gregory T.; Robison, Leslie L. [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States)] [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Neglia, Joseph P. [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States)] [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Inskip, Peter D., E-mail: inskippe@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

    2013-03-01T23:59:59.000Z

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  19. Research Areas

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  20. Research Areas

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  1. Research Highlight

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  2. Research Help

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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  3. Research Highlight

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  4. Research Highlight

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  5. Research Highlight

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research Form ResearchThe

  6. The Accessibility of patient information leaflets concerning cervical cancer - the effect of high leaflet readability level and the reader's level of education 

    E-Print Network [OSTI]

    Gale, Jennifer

    2006-01-01T23:59:59.000Z

    Research suggests that many Patient Information Leaflets are written at too high a level for the population to understand. This study took 2 leaflets on Cervical Cancer, with their readability measured using 3 different ...

  7. Cancer Epidemiology Population Health Sciences 750

    E-Print Network [OSTI]

    Sheridan, Jennifer

    -01/5/11-1 Cancer Epidemiology Population Health Sciences 750 3 credits When: Spring 2011 (1 Audience: This course is intended for students in health-related disciplines interested in cancer etiology. the unequal burden of cancer among populations and variations across time and geography, 2. the distinctive

  8. Eligibility: Cancer Survivor ages 35-75

    E-Print Network [OSTI]

    Walter, Peter

    Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

  9. Upper extremity impairments in women with or without lymphedema following breast cancer treatment

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    following breast cancer treatment Betty Smoot & Josephinefollowing breast cancer treatment, women will demonstratelymphedema. Breast cancer treatments include surgery,

  10. European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version

    E-Print Network [OSTI]

    Boyer, Edmond

    European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

  11. Research | Energy Frontier Research Centers

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear Press ReleasesIn the Inorganic PV thrust,Research Home Below

  12. Provider Communication, Self-Reported Health, and Post-Treatment Regret among Young Breast Cancer Survivors

    E-Print Network [OSTI]

    Fernandes-Taylor, Sara

    2010-01-01T23:59:59.000Z

    R. A. (2004). Breast cancer treatment in older women: impactduring and after cancer treatment: an American Cancerlife following prostate cancer treatment. Cancer Invest, 25(

  13. Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial

    E-Print Network [OSTI]

    Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

    2010-01-01T23:59:59.000Z

    cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

  14. Research Highlight

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch

  15. Research and Development with Full Scale Research

    E-Print Network [OSTI]

    Sijpheer, N.; Bakker, E.J.; Opstelten, I.

    2010-01-01T23:59:59.000Z

    One of the research programs of the Energy research Centre of the Netherlands (ECN) concerns the built environment. Several facilities to conduct the research activities are at ECN's disposal. One of these facilities, are five research dwellings...

  16. Summary of Research Instruction Research Instruction

    E-Print Network [OSTI]

    Kaji, Hajime

    for Passive corium cooling system under severe accident and reactor components (e.g. Fuel assembly, Steam Master's Program Doctoral Program Summary of Research Instruction Research Instruction Doctoral Program Summary of Research Instruction Research Instruction Application Code Name

  17. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    creating an image. · A newer process, called full field digital mammography uses digital receptors. #12Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital Bremsstrahlung, a process in which electrons are accelerated against an anode, causing photons to be fired off

  18. DIESEL et CANCER Dominique Lafon

    E-Print Network [OSTI]

    Boyer, Edmond

    1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicité des émissions des moteurs diesel. C'est un sujet qui a beaucoup préoccupé les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicité des émissions du diesel, un rappel de leur composition est

  19. Cancer Cell Targeting Androgen Receptor

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    in the development of endo- crine therapies targeting estrogen production or ER for both breast cancer treatment targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential. Therapies targeting HER2 such as trastuzumab are becoming increasingly important in the treatment of HER2

  20. Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Colon Cancer

    E-Print Network [OSTI]

    Pathi, Satya

    2012-10-19T23:59:59.000Z

    cancer cell lines and tumors exhibit addiction to non-oncogenes such as Sp1, Sp3 and Sp4 for maintaining the oncogenic phenotype and future research will focus on the mechanisms of ROS-mediated targeting of Sp transcription factors which represents a...

  1. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

    E-Print Network [OSTI]

    Brenner, David Jonathan

    Triangle Park, NC 27711; jOffice of Radiation and Indoor Air, Environmental Protection Agency, WashingtonCancer risks attributable to low doses of ionizing radiation: Assessing what we really know David J Infirmary, Oxford OX2 6ME, United Kingdom; dRadiation and Genome Stability Unit, Medical Research Council

  2. The Role of Tumor Microenvironment in the Progression of Prostate Cancer

    E-Print Network [OSTI]

    Mahdavi, Mozhdeh

    2010-05-06T23:59:59.000Z

    research by our lab has made evident 2OST?s essential role in the progression of prostate cancer. My lab noted a four -fold increase in the transcription of 2OST between benign LNCAP cells and highly metastatic C42B cells; knocking out 2OST made cells less...

  3. An Analytics Approach to Designing Clinical Trials for Cancer Dimitris Bertsimas

    E-Print Network [OSTI]

    Bertsimas, Dimitris

    predictions of survival and toxicity outcomes of clinical trials as long as the drugs used have been seenAn Analytics Approach to Designing Clinical Trials for Cancer Dimitris Bertsimas Sloan School drug research and clinical trials are enormous expenses for pharmaceutical companies and the government

  4. Trans-Study Projection of Genomic Biomarkers in Analysis of Oncogene Deregulation and Breast Cancer

    E-Print Network [OSTI]

    West, Mike

    , to animal model experiments, to human outcome studies and clinical trials. The question of how to translate experiments, and the in vivo context is gene expression studies with data generated from human breast tumours Abstract In cancer studies as in many areas of human disease research, gene expression microarray technol

  5. Predictive and therapeutic markers in ovarian cancer

    SciTech Connect (OSTI)

    Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

    2013-03-26T23:59:59.000Z

    Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

  6. Global Health Research | 2 Global Health Research

    E-Print Network [OSTI]

    Rambaut, Andrew

    Global Health Research | 2 Global Health Research Supporting researchers in low- and middle-income countries to carry out health- related research within their own countries. Gl bal Health #12;3 | Global Health Research #12;Global Health Research | 4 We are a global charitable foundation dedicated

  7. RESEARCH ARTICLE Nonlinear Optical Imaging to Evaluate the Impact of

    E-Print Network [OSTI]

    Cheng, Ji-Xin

    nonlinear optical imaging technologies with an early-onset diet-induced obesity breast cancer animal model, they lack three-dimensional information crucial to describe stromal organization in their natural state, a number of research groups have imaged collagen type I, tumor cells expressing green fluorescent protein

  8. PNNL: Research

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  9. Research Highlight

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  1. Research Highlight

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  8. Research Highlight

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    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingle Particle

  9. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingle ParticleThe

  10. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingle

  11. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingleAssessing Impact

  12. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingleAssessing

  13. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingleAssessingThe Two

  14. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearch FindsASingleAssessingThe

  15. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearchMaking Sense of Convective

  16. Research Library

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements Recently ApprovedReliabilityPrincipalResearchMakingHighlightsSubmitLibrary

  17. Research Projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronic Public Reading Room Electronic PublicResearchCurrent

  18. Research Facility,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7 2ResearchAreas and

  19. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research Form

  20. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research FormImportance of

  1. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research FormImportance

  2. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research FormImportanceAn

  3. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7Research

  4. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7ResearchIntegrated Water

  5. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7ResearchIntegrated

  6. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7ResearchIntegratedCloud

  7. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection Technical s o Freiberge s 3 % A PB 2 7 7ResearchIntegratedCloudARM

  8. Cancer in Ireland 1994-2004: A comprehensive report

    E-Print Network [OSTI]

    Müller, Jens-Dominik

    Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

  9. PrincetonUniversity In-Vitro Studies of Cancer

    E-Print Network [OSTI]

    Petta, Jason

    PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

  10. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  11. Research | Photosynthetic Antenna Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItemResearch > TheNuclear Press ReleasesIn the Inorganic PV

  12. NREL: Biomass Research - Research Staff

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gifNREL NRELChemical and CatalystNewResearch Staff Find

  13. Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam

    E-Print Network [OSTI]

    Petta, Jason

    Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

  14. Clinical Research Unit Translating research from

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Clinical Research Unit Translating research from bench to bedside www.niehs.nih.gov/clinicalunit #12;National Institute of Environmental Health Sciences Clinical Research Program The National Institute of Environmental Health Sciences (NIEHS) Clinical Research Program and the Clinical Research Unit

  15. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Joe Gray

    2010-01-08T23:59:59.000Z

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  16. age gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  17. advanced gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  18. aggressive gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  19. Microwave imaging for ultra-wideband antenna based cancer detection 

    E-Print Network [OSTI]

    Zhang, Haoyu

    2015-06-29T23:59:59.000Z

    Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

  20. The genomic complexity of primary human prostate cancer

    E-Print Network [OSTI]

    Carter, Scott Lambert

    Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

  1. Perspectives on the mesenchymal origin of metastatic cancer

    E-Print Network [OSTI]

    Huysentruyt, Leanne C.; Seyfried, Thomas N.

    2010-01-01T23:59:59.000Z

    of metastasis. Nature Reviews Cancer, 9(4), 239–252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

  2. Research and Development with Full Scale Research 

    E-Print Network [OSTI]

    Sijpheer, N.; Bakker, E.J.; Opstelten, I.

    2010-01-01T23:59:59.000Z

    One of the research programs of the Energy research Centre of the Netherlands (ECN) concerns the built environment. Several facilities to conduct the research activities are at ECN's disposal. One of these facilities, are ...

  3. Modern mathematics for modern cancer medicine ACC Coolen, July 2013 Modern Mathematics for Modern Cancer Medicine

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    by developing advanced quantitative techniques, and applying them to cancer data analysis, outcome and treatment individual treatment response, and low success rates of medical trials. To extend and save lives of cancer of good or poor cancer outcomes, of response to specific treatments, or of metastasis sites. Unfortunately

  4. Nutrition and Cancer 1998, 32 (3) 165 NUTRITION AND CANCER 1998, 32 (3),165-173.

    E-Print Network [OSTI]

    Boyer, Edmond

    or processed meat is associated with increased risk of colon cancer. In contrast, consumption of white meat supplied by 1) lard and casein, 2) olive oil and casein, 3) beef, 4) chicken with skin, and 5) bacon. Meat, France. Introduction Colorectal cancer is the second most common cause of death from cancer

  5. Prostate cancer remains the most common cancer in men in the United States, with an

    E-Print Network [OSTI]

    Cai, Long

    Prostate cancer remains the most common cancer in men in the United States, with an estimated of death from cancer in men, with 33,720 estimated deaths (11% of all estimated deaths) in 2011 (REF. 1-year relative survival rate is essentially 100% based on 2001­2007 statistics2 . However, for patients

  6. The National Cancer Survivorship Initiative: new and emerging evidence on the ongoing needs of cancer survivors

    E-Print Network [OSTI]

    Quartly, Graham

    ; #12; A key commitment of the Cancer Reform Strategy (Department of Health, 2007) in UK, and endorsed Floor Portland House, Bressenden Place, London SW1E 5RS, UK; 2 Faculty of Health Sciences, University in Improving Outcomes Strategy for Cancer (Department of Health, 2011), was to establish a National Cancer

  7. Eur J Cancer Prev. Author manuscript Determinants of non-compliance to recommendations on breast cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer Prev. Author manuscript Page /1 11 Determinants of non-compliance to recommendations on breast cancer screening among women participating in the French E3N cohort study Flamant Camille , Gauthier Estelle , Clavel-Chapelon Fran oiseç * E3N, Nutrition, hormones et cancer: pid miologie et pr

  8. J. Clairambault Theorems to treat cancer? Can theorems help treat cancer?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    J. Clairambault Theorems to treat cancer? Can theorems help treat cancer? Jean Clairambault 1 INRIA who treat patients with can- cer? Can mathematics have an impact on cancer biology? Is mathematics more than just a tool in the hands of [a few open-minded] physicians willing to understand and treat

  9. Cancer Institute of New Jersey: University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey. Environmental Assessment

    SciTech Connect (OSTI)

    Not Available

    1994-06-01T23:59:59.000Z

    The Department of Energy (DOE) proposes to authorize the University of Medicine and Dentistry of New Jersey to proceed with the design, construction, and equipping of the proposed Clinical Treatment and Research Facility of the University of New Jersey on the New Brunswick campus. The facility will provide for the integration of new and existing clinical outpatient cancer treatment with basic and clinical research to expedite the application of new discoveries in cancer treatment. Based on the analysis in the environmental assessment, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA).

  10. Cutaneous cancers in Calabar, Southern Nigeria

    E-Print Network [OSTI]

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01T23:59:59.000Z

    Skin cancer in Zaria, Nigeria. Trop Doct 1995; 25(Suppl. ):Malignancies in Kano, Northern Nigeria: A histopathologicalequatorial rain forest of Nigeria. International Journal of

  11. Research Frontiers Cutting-Edge Research

    E-Print Network [OSTI]

    Takada, Shoji

    Research Frontiers Cutting-Edge Research in Kyoto University Kyoto University is known. Some of them exhibit circularly polarized light (CPL) with unprecedented anisotropy factors: they emit

  12. advanced colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from multiple specialties work together under Engineering Websites Summary: BREAST CANCER PROGRAM A team of breast cancer experts from multiple specialties work together under...

  13. Isotope production facility produces cancer-fighting actinium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

  14. Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Immunosensor for Cancer Biomarker Based on Dual Signal Amplification Strategy of Graphene Sheets and Multi-Enzyme Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

  15. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive...

  16. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  17. Proteogenomic characterization of human colon and rectal cancer...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    characterization of human colon and rectal cancer. Proteogenomic characterization of human colon and rectal cancer. Abstract: We analyzed proteomes of colon and rectal tumors...

  18. Biocompatible core-shell magnetic nanoparticles for cancer treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biocompatible core-shell magnetic nanoparticles for cancer treatment. Biocompatible core-shell magnetic nanoparticles for cancer treatment. Abstract: Non-toxic magnetic...

  19. Blood Peptidome-Degradome Profile of Breast Cancer. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blood Peptidome-Degradome Profile of Breast Cancer. Blood Peptidome-Degradome Profile of Breast Cancer. Abstract: We report on the degradomic-peptidomic insights into blood plasma...

  20. Searching for a system: The quest for ovarian cancer biomarkers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Searching for a system: The quest for ovarian cancer biomarkers. Searching for a system: The quest for ovarian cancer biomarkers. Abstract: The stark difference in clinical outcome...

  1. advanced bladder cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Mortality Kenneth G. Brown; Barbara D. Beck; Claudia Hopenhayn-Rich; Mary Lou Biggs; Allan H. Smith Biology and Medicine Websites Summary: Arsenic and Bladder Cancer...

  2. adult cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Center's Adult Patient & Family Advisory Council Page 1 of 3 and compassionate health care provided by Dana-FarberBrigham and Women's Cancer Center. Working in active...

  3. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery ­ Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  4. Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer

    E-Print Network [OSTI]

    Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

    2013-01-01T23:59:59.000Z

    company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

  5. Research Documentation Guidelines Capturing knowledge, improving research

    E-Print Network [OSTI]

    Sommerville, Ian

    researchers. The RAISER development process is an SDLC specific to Software Engineering by Computer Science

  6. Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells

    SciTech Connect (OSTI)

    Hisatsune, Akinori, E-mail: hisatsun@kumamoto-u.ac.jp [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan)] [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan); Nakayama, Hideki; Kawasaki, Mitsuru; Horie, Ichiro [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan)] [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan); Miyata, Takeshi [Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto City, Kumamoto 862-0082 (Japan)] [Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto City, Kumamoto 862-0082 (Japan); Isohama, Yoichiro [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan)] [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan); Kim, Kwang Chul [Department of Physiology and Lung Center, Temple University School of Medicine, Philadelphia, PA 19140 (United States)] [Department of Physiology and Lung Center, Temple University School of Medicine, Philadelphia, PA 19140 (United States); Katsuki, Hiroshi [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan)] [Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Kumamoto 862-0973 (Japan)

    2011-02-18T23:59:59.000Z

    Research highlights: {yields} We identified changes in the expression and function of EGFR by anti-MUC1 antibody. {yields} An anti-MUC1 antibody GP1.4 decreased EGFR from cell surface by internalization. {yields} GP1.4 specifically inhibited ERK signaling triggered EGF-EGFR signaling pathway. {yields} Internalization of EGFR was dependent on the presence of MUC1 on cell surface. {yields} GP1.4 significantly inhibited EGF-dependent cancer cell proliferation and migration. -- Abstract: MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells. High expression of MUC1 is closely associated with cancer progression and metastasis, leading to poor prognosis. We previously reported that MUC1 is internalized by the binding of the anti-MUC1 antibody, from the cell surface to the intracellular region via the macropinocytotic pathway. Since MUC1 is closely associated with ErbBs, such as EGF receptor (EGFR) in cancer cells, we examined the effect of the anti-MUC1 antibody on EGFR trafficking. Our results show that: (1) anti-MUC1 antibody GP1.4, but not another anti-MUC1 antibody C595, triggered the internalization of EGFR in pancreatic cancer cells; (2) internalization of EGFR by GP1.4 resulted in the inhibition of ERK phosphorylation by EGF stimulation, in a MUC1 dependent manner; (3) inhibition of ERK phosphorylation by GP1.4 resulted in the suppression of proliferation and migration of pancreatic cancer cells. We conclude that the internalization of EGFR by anti-MUC1 antibody GP1.4 inhibits the progression of cancer cells via the inhibition of EGFR signaling.

  7. EDITORIAL Open Access Toward integrative cancer immunotherapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells themselves. There is now widespread appreciation that the progressive growth and metastatic spread of cancer cells requires the cooperation of normal host cells (endothelial cells

  8. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, M.J.; Weaver, V.M.

    1998-12-08T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

  9. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    1998-01-01T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  10. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J. [Stanford Univ. School of Medicine, CA (United States)

    1997-03-01T23:59:59.000Z

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  11. The use of complementary and alternative medicine among breast cancer survivors : the women's healthy eating and living study perspective

    E-Print Network [OSTI]

    Saquib, Juliann

    2010-01-01T23:59:59.000Z

    disparities in breast cancer treatment. J Clin Oncol 2007;based trends in cancer treatment. J Natl Cancer Inst 2005;use systemic cancer treatments across tumor characteristics

  12. The usefulness of three-dimensional cell culture in induction of cancer stem cells from esophageal squamous cell carcinoma cell lines

    SciTech Connect (OSTI)

    Fujiwara, Daisuke [Department of Esophageal and Gastroenterological Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)] [Department of Esophageal and Gastroenterological Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Kato, Kazunori, E-mail: kzkatou@juntendo.ac.jp [Department of Biomedical Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585 (Japan) [Department of Biomedical Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585 (Japan); Department of Atopy Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Nohara, Shigeo; Iwanuma, Yoshimi; Kajiyama, Yoshiaki [Department of Esophageal and Gastroenterological Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)] [Department of Esophageal and Gastroenterological Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

    2013-05-17T23:59:59.000Z

    Highlights: •Spheroids were created from esophageal carcinoma cells using NanoCulture® Plates. •The proportion of strongly ALDH-positive cells increased in 3-D culture. •Expression of cancer stem cell-related genes was enhanced in 3-D culture. •CA-9 expression was enhanced, suggesting hypoxia had been induced in 3-D culture. •Drug resistance was increased. 3-D culture is useful for inducing cancer stem cells. -- Abstract: In recent years, research on resistance to chemotherapy and radiotherapy in cancer treatment has come under the spotlight, and researchers have also begun investigating the relationship between resistance and cancer stem cells. Cancer stem cells are assumed to be present in esophageal cancer, but experimental methods for identification and culture of these cells have not yet been established. To solve this problem, we created spheroids using a NanoCulture® Plate (NCP) for 3-dimensional (3-D) cell culture, which was designed as a means for experimentally reproducing the 3-D structures found in the body. We investigated the potential for induction of cancer stem cells from esophageal cancer cells. Using flow cytometry we analyzed the expression of surface antigen markers CD44, CD133, CD338 (ABCG2), CD318 (CDCP1), and CD326 (EpCAM), which are known cancer stem cell markers. None of these surface antigen markers showed enhanced expression in 3-D cultured cells. We then analyzed aldehyde dehydrogenase (ALDH) enzymatic activity using the ALDEFLUOR reagent, which can identify immature cells such as stem cells and precursor cells. 3-D-cultured cells were strongly positive for ALDH enzyme activity. We also analyzed the expression of the stem cell-related genes Sox-2, Nanog, Oct3/4, and Lin28 using RT-PCR. Expression of Sox-2, Nanog, and Lin28 was enhanced. Analysis of expression of the hypoxic surface antigen marker carbonic anhydrase-9 (CA-9), which is an indicator of cancer stem cell induction and maintenance, revealed that CA-9 expression was enhanced, suggesting that hypoxia had been induced. Comparison of cancer drug resistance using cisplatin and doxorubicin in 3-D-cultured esophageal cancer cells showed that cancer drug resistance had increased. These results indicate that 3-D culture of esophageal squamous cell carcinoma lines is a useful method for inducing cancer stem cells.

  13. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  14. Metabolism and proliferation share common regulatory pathways in cancer

    E-Print Network [OSTI]

    Boyer, Edmond

    Metabolism and proliferation share common regulatory pathways in cancer cells. Vanessa Fritz, proliferation, and cancer inserm-00491405,version1-11Jun2010 Author manuscript, published in "Oncogene 2010;29(31):4369-77" DOI : 10.1038/onc.2010.182 #12;Metabolism, proliferation and cancer Fritz and Fajas 2 Abstract Cancer

  15. "Skin Cancer-What to Look For" Rochester Recreation

    E-Print Network [OSTI]

    Goldman, Steven A.

    "Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

  16. Cancer Cells DOI: 10.1002/anie.201100115

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201100115 Micromachine-Enabled Capture and Isolation of Cancer Cells (CTCs) are the primary entities responsible for spawning cancer metastasis. Detection of CTCs provides an indicator for the clinical diagnosis and prognosis of various types of cancers. Several approaches, based

  17. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  18. Radio Sensors to Help Detect Cancer Monday, July 28, 2008 -Anni Shaer Levitt

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    , Treatments & Facts on Breast Cancer Cancers Acid Reflux Causes Cancer A free, informative online video.RefluxRemedy.com American Cancer Society Get the latest information on stomach cancer treatments www.cancerSearch Home Headlines News Articles Forums Radio Sensors to Help Detect Cancer Monday, July 28

  19. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect (OSTI)

    Zhang, Jie [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Zheng, Fangxia [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China); Yu, Gang [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China)] [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China); Yin, Yanhua, E-mail: yinyanhuablk@163.com [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Lu, Qingyang [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)

    2013-11-01T23:59:59.000Z

    Highlights: •miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. •miR-196a expression elevated proliferation and migration of cervical cancer cells. •miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. •NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. •NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 2–3 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of miR-196a in cervical carcinogenesis and suggested a potential use of miR-196a for clinical diagnosis and as a therapeutic target.

  20. An online survey to find out how people manage cancer and cancer related problems in the 12

    E-Print Network [OSTI]

    Anderson, Jim

    following initial cancer treatment There are around two million people in the UK living with or beyond cancer and this number is rising by more than 3% per year. Treatments for cancer such as chemotherapy manage most problems associated with cancer and its treatment on their own as part of their daily lives

  1. Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one

    E-Print Network [OSTI]

    Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17Ã?-estradiol. An established cancer model was used

  2. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  3. Research Councils UK Transforming

    E-Print Network [OSTI]

    Berzins, M.

    Research Councils UK Transforming our energy future #12;Research funded by the Research Councils in 2002 to create a viable renewable energy research community to foster industrial engagement of research, expertise and the business capability to develop and exploit them commercially. Energy and its

  4. External Research Funding Agreements

    E-Print Network [OSTI]

    Victoria, University of

    1 External Research Funding Agreements University Policy No: RH8200 Classification: Research and university employees under Research Funding Agreements. DEFINITIONS 2.00 Research Funding Agreement means funding provided through an agreement with the university to be used for research purposes, whether

  5. Forest Research: Climate Change

    E-Print Network [OSTI]

    Forest Research: Climate Change projects Forest Research is part of the Forestry Commission of climate change-related research is wide-ranging, covering impact assessment and monitoring, adaptation around a quarter of its research budget with Forest Research on climate change and related programmes

  6. A Framework for Developing, Implementing, and Evaluating a Cancer Survivorship Curriculum for Medical Students

    E-Print Network [OSTI]

    Uijtdehaage, Sebastian; Hauer, Karen E.; Stuber, Margaret; Rajagopalan, Shobita; Go, Vay L.; Wilkerson, LuAnn

    2009-01-01T23:59:59.000Z

    the impact of cancer and treatment on their relation- ships,term consequences of cancer treatments. Furthermore, whileincluding details of cancer treatment and follow-up. In

  7. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01T23:59:59.000Z

    you heard about cancer treatment summaries or survivorshipthe course of breast cancer treatment should patients beginduring their active cancer treatment (surgery, radiation,

  8. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, S-J

    2010-01-01T23:59:59.000Z

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  9. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01T23:59:59.000Z

    1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

  10. Lung Cancer as a Second Primary Malignancy: Increasing Prevalence and Its Influence on Survival

    E-Print Network [OSTI]

    Quadrelli, Silvia; Lyons, Gustavo; Colt, Henri; Chimondeguy, Domingo; Silva, Carlos

    2009-01-01T23:59:59.000Z

    therapy for multiple primary lung cancers. Chest. REFERENCEMR. Multiple primary lung cancers. J Thorac Cardiovasc Surg.606–12. 2. Johnson BE. Second lung cancers in patients after

  11. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Molecular pathogenesis of lung cancer,” Annual Review ofp63 immunoreac- tivity in lung cancer: yet another player inprotein-related genes in lung cancer: correlation with drug

  12. advanced head-and-neck cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in skin cancer, colorectal carcinoma, testicular teratoma and liver cancer types: brain, breast, head and neck, renal, skin and testicular cancers. Conclusions: SULF1 and...

  13. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

    E-Print Network [OSTI]

    Fendt, Sarah-Maria

    Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer ...

  14. Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

    E-Print Network [OSTI]

    Walker, Logan C; Fredericksen, Zachary S; Wang, Xianshu; Tarrell, Robert; Pankratz, Vernon Shane; Lindor, Noralane M; Beesley, Jonathan; Healey, Sue; Chen, Xiaoqing; (kConFab), Kathleen Cuningham Foundation Consortium for Research; Stoppa-Lyonnet, Dominique; Tirapo, Carole; Giraud, Sophie; Mazoyer, Sylvie; Muller, Daniele; Fricker, Jean-Pierre; Delnatte, Capucine; (gemo), Groupe Genetique et Cancer; Schmutzler, Rita K; Wappenschmidt, Barbara; Engel, Christoph; Schonbuchner, Ines; Deissler, Helmut; Meindl, Alfons; Hogervorst, Frans B; Verheus, Martijn; Hooning, Maartje J; van den Ouweland, Ans M W; Nelen, Marcel R; Ausems, Margreet G E M; Aalfs, Cora M; van Asperen, Christi J; Devilee, Peter; Gerrits, Monique M; Waisfisz, Quinten; (hebon), Hereditary Breast and Ovarian Cancer Research Group Netherlands; Szabo, Csilla I; ModSQuaD, The; Easton, Douglas F; Peock, Susan; Cook, Margaret; Oliver, Clare T; Frost, Debra; Harrington, Patricia; Evans, D Gareth; Lalloo, Fiona; Eeles, Rosalind; Izatt, Louise; Chu, Carol; Davidson, Rosemarie; Eccles, Diana; Ong, Kai-Ren; Cook, Jackie; Embrace, The; Rebbeck, Timothy R; Nathanson, Katherine L; Domchek, Susan M; Singer, Christian F; Gschwantler-Kaulich, Daphne; Dressler, Anne-Catharina; Pfeiler, Georg; Godwin, Andrew K; Heikkinen, Tuomas; Nevanlinna, Heli; Agnarsson, Bjarni A; Caligo, Maria Adelaide; Olsson, Hakan; Kristoffersson, Ulf; Liljegren, Annelie; Arver, Brita; Karlsson, Per; Melin, Beatrice; (swe-brca), Swedish Breast Cancer Study; Sinilnikova, Olga M; McGuffog, Lesley; Antoniou, Antonis C; Chenevix-Trench, Georgia; Spurdle, Amanda B; Couch, Fergus J

    2010-11-29T23:59:59.000Z

    RESEARCH ARTICLE Open Access Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers Logan C Walker1, Zachary S Fredericksen2, Xianshu Wang2, Robert Tarrell2, Vernon S Pankratz2, Noralane M Lindor2, Jonathan Beesley1, Sue... Service, Birmingham (Trevor Cole, Carole McKeown, Kai-Ren Ong, Laura Boyes); South West Regional Genetics Service, Bristol (Alan Donaldson); East Anglian Regional Genetics Service, Cambridge (Joan Paterson); Medical Genetics Services for Wales, Cardiff...

  15. Treatment Techniques and Site Considerations Regarding Dysphagia-Related Quality of Life in Cancer of the Oropharynx and Nasopharynx

    SciTech Connect (OSTI)

    Teguh, David N. [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands); Levendag, Peter C. [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands)], E-mail: p.levendag@erasmusmc.nl; Noever, Inge; Rooij, Peter van; Voet, Peter; Est, Henrie van der; Sipkema, Dick [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands); Sewnaik, Aniel; Baatenburg de Jong, Robert Jan [Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands); Bije, Daniel de la [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands); Schmitz, Paul [Department of Biostatistics, Erasmus Medical Center - Daniel den Hoed, Rotterdam (Netherlands)

    2008-11-15T23:59:59.000Z

    Purpose: To assess the relationship for oropharyngeal (OP) cancer and nasopharyngeal (NP) cancer between the dose received by the swallowing structures and the dysphagia related quality of life (QoL). Methods and Materials: Between 2000 and 2005, 85 OP and 47 NP cancer patients were treated by radiation therapy. After 46 Gy, OP cancer is boosted by intensity-modulated radiation therapy (IMRT), brachytherapy (BT), or frameless stereotactic radiation/cyberknife (CBK). After 46 Gy, the NP cancer was boosted with parallel-opposed fields or IMRT to a total dose of 70 Gy; subsequently, a second boost was given by either BT (11 Gy) or stereotactic radiation (SRT)/CBK (11.2 Gy). Sixty OP and 21 NP cancer patients responded to functional and QoL questionnaires (i.e., the Performance Status Scales, European Organization for Research and Treatment of Cancer H and N35, and M.D. Anderson Dysphagia Inventory). The swallowing muscles were delineated and the mean dose calculated using the original three-dimensional computed tomography-based treatment plans. Univariate analyses were performed using logistic regression analysis. Results: Most dysphagia problems were observed in the base of tongue tumors. For OP cancer, boosting with IMRT resulted in more dysphagia as opposed to BT or SRT/CBK. For NPC patients, in contrast to the first booster dose (46-70 Gy), no additional increase of dysphagia by the second boost was observed. Conclusions: The lowest mean doses of radiation to the swallowing muscles were achieved when using BT as opposed to SRT/CBK or IMRT. For the 81 patients alive with no evidence of disease for at least 1 year, a dose-effect relationship was observed between the dose in the superior constrictor muscle and the 'normalcy of diet' (Performance Status Scales) or 'swallowing scale' (H and N35) scores (p < 0.01)

  16. RESEARCH INFRASTRUCTURES Roadmap 2008

    E-Print Network [OSTI]

    Horn, David

    RESEARCH INFRASTRUCTURES FOR FRANCE Roadmap 2008 #12;INTRODUCTION European research infrastructures and development, benefiting to Europe's economy and competitiveness. This roadmap for the research infrastructures....................................................................................................6 3. The roadmap: existing and already decided RIs and others at the planning stage

  17. INTERNATIONAL PACIFIC RESEARCH CENTER

    E-Print Network [OSTI]

    Wang, Yuqing

    INTERNATIONAL PACIFIC RESEARCH CENTER APRIL 2004­MARCH 2005 REPORT SCHOOL OF OCEAN AND EARTH RESEARCH HIGHLIGHTS Indo-Pacific Ocean Climate Pacific Research Center Design by: Susan Yamamoto Printed by: Hagadone Printing Company Photo: Waikiki

  18. Universiteit Antwerpen Research Methods

    E-Print Network [OSTI]

    Nierstrasz, Oscar

    Methods Science vs. Engineering 5 Science Engineering Physics Chemistry Biology Mathematics ElectroUniversiteit Antwerpen Research Methods in Computer Science (Serge Demeyer -- University of Antwerp Introduction · Origins of Computer Science · Research Philosophy Research Methods · Feasibility study · Pilot

  19. Applying for Research Awards

    E-Print Network [OSTI]

    ... 53.22 KB APPLYING FOR RESEARCH AWARDS The Eastern Bird Banding Association seeks applicants for its annual $500 research awards in aid of research using banding techniques or bird banding data. ...

  20. The Quality-of-Life Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer

    SciTech Connect (OSTI)

    Herman, Joseph M., E-mail: jherma15@jhmi.edu [Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Narang, Amol K. [Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Griffith, Kent A. [Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Zalupski, Mark M. [Department of Hematology Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Hematology Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Reese, Jennifer B. [Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Gearhart, Susan L. [Department of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States) [Department of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Azad, Nolifer S. [Department of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Chan, June; Olsen, Leah [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Efron, Jonathan E. [Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)] [Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Lawrence, Theodore S.; Ben-Josef, Edgar [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)

    2013-01-01T23:59:59.000Z

    Purpose: Existing studies that examine the effect of neoadjuvant chemoradiation (CRT) for locally advanced rectal cancer on patient quality of life (QOL) are limited. Our goals were to prospectively explore acute changes in patient-reported QOL endpoints during and after treatment and to establish a distribution of scores that could be used for comparison as new treatment modalities emerge. Methods and Materials: Fifty patients with locally advanced rectal cancer were prospectively enrolled at 2 institutions. Validated cancer-specific European Organization for Research and Treatment of Cancer (EORTC QLQ-CR30) and colorectal cancer-specific (EORTC QLQ-CR38 and EORTC QLQ-CR 29) QOL questionnaires were administered to patients 1 month before they began CRT, at week 4 of CRT, and 1 month after they had finished CRT. The questionnaires included multiple symptom scales, functional domains, and a composite global QOL score. Additionally, a toxicity scale was completed by providers 1 month before the beginning of CRT, weekly during treatment, and 1 month after the end of CRT. Results: Global QOL showed a statistically significant and borderline clinically significant decrease during CRT (-9.50, P=.0024) but returned to baseline 1 month after the end of treatment (-0.33, P=.9205). Symptoms during treatment were mostly gastrointestinal (nausea/vomiting +9.94, P<.0001; and diarrhea +16.67, P=.0022), urinary (dysuria +13.33, P<.0001; and frequency +11.82, P=.0006) or fatigue (+16.22, P<.0001). These symptoms returned to baseline after therapy. However, sexual enjoyment (P=.0236) and sexual function (P=.0047) remained persistently diminished after therapy. Conclusions: Rectal cancer patients undergoing neoadjuvant CRT may experience a reduction in global QOL along with significant gastrointestinal and genitourinary symptoms during treatment. Moreover, provider-rated toxicity scales may not fully capture this decrease in patient-reported QOL. Although most symptoms are transient, impairment in sexual function may persist after the completion of therapy and merits further investigation.

  1. Micro and nanotechnology for cancer treatment

    E-Print Network [OSTI]

    Ullal, Adeeti (Adeeti Vedantham)

    2013-01-01T23:59:59.000Z

    Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

  2. Near infrared optical lymphography for cancer diagnostics

    E-Print Network [OSTI]

    Houston, Jessica Perea

    2007-04-25T23:59:59.000Z

    A new molecular imaging modality has been developed to detect and locate positive axillary and sentinel lymph nodes non-invasively in breast cancer patients undergoing lymphoscintigraphy. The modality is based on fluorescent photon detection...

  3. Intestinal cancer : linking infection, inflammation and neoplasia

    E-Print Network [OSTI]

    Sohn, Jane Joo-hee, 1976-

    2005-01-01T23:59:59.000Z

    Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular ...

  4. Investigation into taxane resistant breast cancer 

    E-Print Network [OSTI]

    Kenicer, Juliet Elisabeth Margaret

    2011-11-25T23:59:59.000Z

    One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

  5. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01T23:59:59.000Z

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  6. Cancer Cell Metabolism: One Hallmark, Many Faces

    E-Print Network [OSTI]

    Sabatini, David M.

    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...

  7. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01T23:59:59.000Z

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  8. Somatic retrotransposition in the cancer genome

    E-Print Network [OSTI]

    Helman, Elena

    2014-01-01T23:59:59.000Z

    Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...

  9. Sandia Hydrogen Combustion Research

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Combustion Research Sandia Hydrogen Combustion Research Sebastian A. Kaiser (PI) Sandia National Laboratories Christopher M. White University of New Hampshire Sponsor: DoE...

  10. Nuclear Physics: Experiment Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UserResearcher Information print version Research Highlights Public Interest Nuclear Physics Accelerator Free Electron Laser (FEL) Medical Imaging Physics Topics Campaigns...

  11. Operations Research Analyst

    Broader source: Energy.gov [DOE]

    The incumbent in this position will serve as an Operations Research Analyst in the Generation Scheduling (PGS). The Operations Research Analyst is responsible for analytical work that involves...

  12. Prof. Ian H. Hutchinson Professor of Nuclear Science and Engineering, MIT.

    E-Print Network [OSTI]

    Chen, Sow-Hsin

    ) is Professor of Nuclear Science and Engineering at the Massachusetts Institute of Technology. His primary configuration, the Reversed Field Pinch, with the U.K. Atomic En- ergy Authority, where he made landmark

  13. Monolithically integrated InP-based tunable wavelength conversion John M. Hutchinson*1

    E-Print Network [OSTI]

    Coldren, Larry A.

    The simplest photocurrent-driven wavelength converter (PD-WC) consists of a photodiode receiver directly such as implemented in the sampled-gating distributed Bragg reflector (SGDBR) laser [10]. A separate DC electrode

  14. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    SciTech Connect (OSTI)

    Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

    2009-06-18T23:59:59.000Z

    Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

  15. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A., E-mail: kleinerr@mail.nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Holowaty, Eric [Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario (Canada); Hall, Per [Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm (Sweden); Pukkala, Eero [Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki (Finland); Vaalavirta, Leila [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Stovall, Marilyn; Weathers, Rita [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kaijser, Magnus [Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm (Sweden); Andersson, Michael [Department of Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Storm, Hans [Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (Denmark); Joensuu, Heikki [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, Iowa (United States); and others

    2013-08-01T23:59:59.000Z

    Purpose: To assess the dose–response relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched case–control study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation dose–response relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear dose–response relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  16. RESEARCH ARTICLE OFFICIAL JOURNAL

    E-Print Network [OSTI]

    Yu, Haiyuan

    online 5 March 2014 in Wiley Online Library (www.wiley.com/humanmutation). DOI: 10.1002/humu.22534.yu@cornell.edu Contract grant sponsors: National Cancer Institute (grant CA167824); National In- stitute of General structures and dis- ordered elements play a role in modulating function [Lahiry et al., 2010]. Protein

  17. Biomedical Innovation | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    damaged hearts after heart attacks and eliminating insulin injections to treat diabetes, to enabling new ways to battle cancer and even someday growing entire organs, cell...

  18. Research at Research Development Services and

    E-Print Network [OSTI]

    · $400M ongoing upgrade · FEL Light Source (~14kW) CEBAF #12;Alternative Energy ·Algal Biodiesel Research

  19. Sandia National Laboratories: Research: Research Foundations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Effects and High Energy Density Science Rings of Saturn, Sandia's workhorse pulsed-power machine. The Radiation Effects and High Energy Density Science Research...

  20. Postdoctoral Research Awards Annual Research Meeting: Jun Lu...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Jun Lu Postdoctoral Research Awards Annual Research Meeting: Jun Lu Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the U.S. Department...

  1. Postdoctoral Research Awards Annual Research Meeting: Jared Clark...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Jared Clark Postdoctoral Research Awards Annual Research Meeting: Jared Clark Poster Presentation at the 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  2. Postdoctoral Research Awards Annual Research Meeting: Sarah Hobdey...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sarah Hobdey Postdoctoral Research Awards Annual Research Meeting: Sarah Hobdey Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  3. Postdoctoral Research Awards Annual Research Meeting: Neil Dasgupta...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Neil Dasgupta Postdoctoral Research Awards Annual Research Meeting: Neil Dasgupta Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  4. Postdoctoral Research Awards Annual Research Meeting: David Lampert...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    David Lampert Postdoctoral Research Awards Annual Research Meeting: David Lampert Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  5. Postdoctoral Research Awards Annual Research Meeting: Brian Larsen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Brian Larsen Postdoctoral Research Awards Annual Research Meeting: Brian Larsen Poster Presentation at 2012 EERE Annual Research Meeting, Postdoctoral Research Awards, from the...

  6. Animal Testing Medical Research

    E-Print Network [OSTI]

    Bech, Claus

    Arondsen Marit Gystøl #12;ZO-8091 Forsøksdyrlære Animal experiments in medical research NTNU ­ Norges ..................................................................................................................................................... 14 #12;ZO-8091 Forsøksdyrlære Animal experiments in medical research NTNU ­ Norges Teknisk have come from animal research. Animal research is defined as the use of non-human animals

  7. Jahresbericht der Research Academy

    E-Print Network [OSTI]

    Schüler, Axel

    Jahresbericht der Research Academy Leipzig 2008 #12;Inhalt Die Research Academy Leipzig 3 Vorwort Research Academy Leipzig im Aufwind 3 Die Arbeit der RAL-Doktorandenvertretung 2008 4 Fächerübergreifendes Qualifikationsprogramm Die Veranstaltungen der Research Academy Leipzig 2008 5 Seminar ,,Junge Wissenschaft und Praxis" 6

  8. Microsoft External Research Backgrounder

    E-Print Network [OSTI]

    Narasayya, Vivek

    are undeniable. M icrosoft Research believes that collaboration between the public and private sectors, combined with the power of computing, can help researchers as they work to solve the most urgent challenges in medicine, Building the Future of Technology Microsoft External Research Backgrounder #12;The team promotes research

  9. The host immunological response to cancer therapy: An emerging concept in tumor biology

    SciTech Connect (OSTI)

    Voloshin, Tali [Department of Molecular Pharmacology, Rappaport Faculty of Medicine and the Rappaport Institute, Technion—Israel Institute of Technology, 1 Efron Street, Bat Galim, Haifa 31096 (Israel); Voest, Emile E. [Department of Medical Oncology, University Medical Center Utrecht, Utrecht (Netherlands); Shaked, Yuval, E-mail: yshaked@tx.technion.ac.il [Department of Molecular Pharmacology, Rappaport Faculty of Medicine and the Rappaport Institute, Technion—Israel Institute of Technology, 1 Efron Street, Bat Galim, Haifa 31096 (Israel)

    2013-07-01T23:59:59.000Z

    Almost any type of anti-cancer treatment including chemotherapy, radiation, surgery and targeted drugs can induce host molecular and cellular immunological effects which, in turn, can lead to tumor outgrowth and relapse despite an initial successful therapy outcome. Tumor relapse due to host immunological effects is attributed to angiogenesis, tumor cell dissemination from the primary tumors and seeding at metastatic sites. This short review will describe the types of host cells that participate in this process, the types of factors secreted from the host following therapy that can promote tumor re-growth, and the possible implications of this unique and yet only partially-known process. It is postulated that blocking these specific immunological effects in the reactive host in response to cancer therapy may aid in identifying new host-dependent targets for cancer, which in combination with conventional treatments can prolong therapy efficacy and extend survival. Additional studies investigating this specific research direction—both in preclinical models and in the clinical setting are essential in order to advance our understanding of how tumors relapse and evade therapy. -- Highlights: • Cancer therapy induces host molecular and cellular pro-tumorigenic effects. • Host effects in response to therapy may promote tumor relapse and metastasis. • The reactive host consists of immunological mediators promoting tumor re-growth. • Blocking therapy-induced host mediators may improve outcome.

  10. Sports activities and risk of testicular cancer

    E-Print Network [OSTI]

    A. J. Coldman; J. M. Elwooda; R. P. Gallagher; Nottingham Nottingham

    1982-01-01T23:59:59.000Z

    Summary.-The relationship of testicular seminoma with several factors was explored using a case-control study. Previously recognized associations with cryptorchidism and infantile inguinal hernia were confirmed and relationships were also found with cycling and horse-riding. These findings represent the first relationships of testicular cancer with well-defined postnatal risk factors. TESTICULAR CANCER is now the most common neoplasm in men aged 25-34 in England and Wales (Davies, 1981) and follows only non-melanoma skin cancer in Canada (Statistics Canada, 1980). Mortality in young men has been rising during this century in a number of countries (Davies, 1981; Grumet & MacMahon, 1958). Similar increases in incidence have been reported by several cancer registries for the age range 15-30 (Muir & Nectoux, 1978; Schottenfeld et al., 1980; Clemmesen, 1969; Petersen & Lee, 1972). Current estimates of incidence in British Columbia indicate that approximately 1 in 400 males will develop testicular cancer (Cancer Registry, 1975). The majority of studies of the epidemiology of testicular tumours have used routinely collected data to analyse the effects of factors such as social class, marital status, geography, racial group and religious preference. Case-control studies have analysed factors such as cryptorchidism and other prenatal conditions. Where it was examined, these studies have shown that, while differences exist in the age-specific incidence, treatment and prognosis of seminoma compared to other types of testicular cancer, the relationship to known risk factors is similar (Morrison, 1976b; Graham et al., 1977). The present report examines a number of characteristics of childhood and adolescence in a case-control study of all patients treated for seminoma of the testis at a regional treatment centre in the period 1970-77.

  11. Research Roadmap Presentation

    E-Print Network [OSTI]

    Sloman, Aaron

    Research Roadmap Presentation: euCognition Meeting, Munich 12 Jan 2007 http://www.eucognition.org/six_monthly_meeting_2.htm What's a Research Roadmap For? Why do we need one? How can we produce one? Aaron Sloman ( http.cs.bham.ac.uk/research/projects/cosy/papers/#pr0701 See also the euCognition Research Roadmap project: http://www.eucognition.org/wiki/index.php?title=Research_Roadmap

  12. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer ­ non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  13. Vol. 4, 869-877, April 1998 Clinical Cancer Research 869 Expression of the Plasminogen Activation System in Kidney Cancer

    E-Print Network [OSTI]

    Jankun, Jerzy

    , by American Diagnostica, Inc., Greenwich, CT, and by MCO Foundation, Toledo, OH. 2 To whom requests, Toledo, OH 43699-0008. Phone: (419)383-3691; Fax: (419)381-3168; E-mail: jerzy@golemxiv.dh.mco.edu; Internet address: http:llgolemxiv.dh. mco.cdu/-jcrzy/. 3 The abbreviations used arc: u-PA, urokinase

  14. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States)] [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States); Ann Stepp, Mary [Medical School, George Washington University, Washington DC 20052 (United States)] [Medical School, George Washington University, Washington DC 20052 (United States); Srinivasan, Priya; Sandler, Anthony [Childrens National Medical Center, Washington DC 20010 (United States)] [Childrens National Medical Center, Washington DC 20010 (United States); Trink, Barry [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)] [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)

    2013-05-15T23:59:59.000Z

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  15. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  16. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  17. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  18. Oestrogen metabolism and action in epithelial ovarian cancer 

    E-Print Network [OSTI]

    Ren, Xia

    2011-11-25T23:59:59.000Z

    Ovarian cancer is the most fatal of all gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumours and is thought to originate mostly from ovarian surface epithelium ...

  19. Function of the anterior gradient protein family in cancer 

    E-Print Network [OSTI]

    Fourtouna, Argyro

    2009-01-01T23:59:59.000Z

    Proteomic technologies verified Anterior Gradient 2, AGR-2, as a protein over-expressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53. AGR-2 gene is a hormone...

  20. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    departments, 1992 to 2001. Ann Emerg Med. 2005;46(1):77-81.term breast cancer survivors. Ann Behav Med. 3. Wu AH, Gomezpositive breast cancer cells. Ann Oncol. 2011;22( 1):68-73.

  1. In vitro study of cancer cell extravasation in microfluidic platform

    E-Print Network [OSTI]

    Jeon, Jessie Sungyun

    2014-01-01T23:59:59.000Z

    Cancer metastases arise from the cancer cells that disseminate from the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of ...

  2. Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer studies Pierre Neuvial Nucleotide Polymorphism (SNP) arrays. We define the copy number states formally, and show how Nucleotide Polymorphism microarrays in cancer studies

  3. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    and their effects on diabetes risk, randomized controlledQiao Q, Zethelius B, et al: Diabetes, prediabetes and cancerS, Lopez A, et al: Diabetes, obesity and survival in a large

  4. HOPKINS, UNIVERSITY OF MD, BALTIMORE FACULTY RESEARCHERS WIN 2014 BIOMARYLAND LIFE PRIZES

    E-Print Network [OSTI]

    Weber, David J.

    ,000 grants help further research, bring new discoveries to commercial market BALTIMORE, MD (February 19, 2014 for her development of a blood test for the early detection of pancreatic cancer. #12;The LIFE prize the funding to develop technology that will aid in the safer delivery of radiation therapy. Previous winners

  5. Environmental Health Perspectives volume 117 | number 1 | January 2009 133 Research | Children's Health

    E-Print Network [OSTI]

    California at Berkeley, University of

    , and lubricating oil. Most previous epidemiologic studies have examined the impact of paint and solvents is the alkyd paints or oil-based resin paints, in which the solvent is usually petro- leum-based and organic crude oil [International Agency for Research on Cancer (IARC) Monograph Working Group 1989], including

  6. Spiritual Coping and Adjustment in Siblings of Children with Cancer 

    E-Print Network [OSTI]

    Kaal, Julia

    2011-11-23T23:59:59.000Z

    Approximately 12 000 US children are diagnosed with some form of cancer every year (Ries et al., 2006)....

  7. Research Teams - Combustion Energy Frontier Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronic Public Reading Room ElectronicResearchResearchResearch

  8. WON EXPOSURE AND LUNG CANCER RISK

    E-Print Network [OSTI]

    unknown authors

    As information on indoor air quality accumulated * it became apparent that radon and its progeny are invariably present in indoor environments and that concentrations may reach unacceptably high levels. The lung cancer excess anong miners exposed to radon progeny raised concern that exposure to radon progeny might also cause lung cancer in the general population. This presentation first provides an ovemiew of radon daughter carcinogenesis, and then reviews the recent BEIR IV report. The report described a statistical model * based on analysis of data from four studies of miners, for estimating the lung cancer risk associated with exposure to radon progeny. Tbe analyses showed that the risk of radon exposure declines with time since exposure and with increasing age. The BEIR IV committee concluded that radon progeny and cigarette smoking interact in a multiplicative fashion and that exposure-dose relationships are similar for exposure in homes and in mines.

  9. Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer any the less? The making of a modern disease.

    E-Print Network [OSTI]

    Shapin, Steven

    Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer-marrow sample taken, but she knows about leukemia. It's cancer of the blood. She's terrified, and she may not just a cancer ward but a cancer world. The ward is what the sociologist Erving Goffman once called

  10. Senior Research Associate Taconite Industry Minerals Research Endowed Chair

    E-Print Network [OSTI]

    Netoff, Theoden

    Senior Research Associate Taconite Industry Minerals Research Endowed Chair Job Requisition 170892 Coleraine Minerals Research Laboratory Natural Resources Research Institute University of Minnesota Duluth (www.nrri.umn.edu) Position Description The Taconite Industry Minerals Research Endowed Chair

  11. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    E-Print Network [OSTI]

    Ren, Yin

    A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes ...

  12. Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    fetal bovine serum and 1610 5 MDA-MB-468 cells were seededwith human breast cancer MDA-MB-468 cells in a transwellNAFs with breast cancer MDA-MB-468 cells in a transwell

  13. High Prevalence of Lung Cancer in a Surgical Cohort of Lung Cancer Patients A Decade After Smoking Cessation

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    AJ, Samet M: Epidemiology of Lung Cancer. Chest 2003, 123:The accumulated evidence on lung cancer and environmentalMR, Fueger JJ, et al: “Lung carcinoma in former smokers”.

  14. Discovering Novel Cancer Therapies: A Computational Modeling and Search Approach

    E-Print Network [OSTI]

    Flann, Nicholas

    of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity-based approach for the discovery of novel potential cancer treatments using a high fidelity simulation in cancer treatment [2]. This paper introduces a computational approach to search for novel intervention

  15. COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1

    E-Print Network [OSTI]

    Sergot, Marek

    COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1 PETER HAMMOND2 AND MAREK SERGOT3 July 1994 Cancer treatment is often carried out within protocol-based clinical trials. An oncology clinic may take of many protocols, the life-threatening nature of cancer and the toxicity of treatment side

  16. An Optimal Control Approach to Cancer Treatment under Immunological Activity

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    An Optimal Control Approach to Cancer Treatment under Immunological Activity Urszula Ledzewicz Mathematical models for cancer treatment that include immunological activity are con- sidered as an optimal. For various growth models on the cancer cells the existence and optimality of singular controls

  17. Optimisation of cancer drug treatments using cell population dynamics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Optimisation of cancer drug treatments using cell population dynamics Fr´ed´erique Billy1 , Jean. The constraints at stake, met everyday in the clinic of cancers, are related mainly to resistance to treatment models used in cancer treatment in the last decades, together with the biological phenomena that can

  18. Controlling the Bone Marrow Dynamics in Cancer Chemotherapy

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    Professor Award 1 #12;find optimal strategies for chemotherapy treatments of the cancer, where Controlling the Bone Marrow Dynamics in Cancer Chemotherapy Urszula Ledzewicz1 and Heinz Sch In the paper a mathematical model for the growth of the bone marrow under cell-cycle specific cancer

  19. QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented

    E-Print Network [OSTI]

    Huston, Dryver R.

    QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented by Zhi He are at risk for developing prostate cancer, and as a man ages, his risk of developing prostate cancer acquiring the ultrasound data, the specimen is sectioned for histological analysis at 2 mm intervals

  20. Cancer Phylogenetics from Single-Cell Assays Gregory Pennington

    E-Print Network [OSTI]

    Cancer Phylogenetics from Single-Cell Assays Gregory Pennington Stanley Shackney Russell Schwartz the Carnegie Mellon University Berkman Faculty Development Fund. #12;Keywords: computational biology, cancer, FISH, phylogeny #12;Abstract In the field of cancer biology, there is currently great interest

  1. Genetic Susceptibility and Survival: Application to Breast Cancer

    E-Print Network [OSTI]

    West, Mike

    Genetic Susceptibility and Survival: Application to Breast Cancer Edwin S. IVERSEN, JR., Giovanni are known to confer an elevated risk of both breast and ovarian cancers. The effect of carrying such a mutation on survival after developing breast or ovarian cancer is less well understood. We investigate

  2. AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER Marius George LINGURARU, Oxford OX2 7BZ, United Kingdom mglin@robots.ox.ac.uk Abstract: The prevalence of breast cancer must provide effective clinical methods to detect cancer and improve life expectancy. Considerable

  3. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  4. Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy

    E-Print Network [OSTI]

    Smith, Elizabeth Brooks

    2009-05-15T23:59:59.000Z

    Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

  5. Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a)

    E-Print Network [OSTI]

    Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a) , Davina Porock(b) , Nick of the study: was to evaluate the attitudinal barriers to cancer-pain management among cnacer patients five factors . These factors contribute to ineffective cancer pain management among them and include

  6. Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer

    E-Print Network [OSTI]

    Chinna Balareddy, Karthik Reddy

    2012-10-19T23:59:59.000Z

    Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13...

  7. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  8. DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER

    E-Print Network [OSTI]

    Raphael, Ben J.

    DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER FABIO VANDIN, PATRICK CLAY,pclay,eli,braphael}@cs.brown.edu A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse

  9. ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE

    E-Print Network [OSTI]

    Ahmad, Sajjad

    ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE by Karl Kingsley, PhD Doctor of Philosophy the thesis prepared under our supervision by Karl Kingsley, Ph.D. entitled Oral Cancer in Nevada: A Public May 2010 #12;iii ABSTRACT Oral Cancer in Nevada: A Public Health Perspective by Karl Kingsley, Ph

  10. Cancer Cell Dissecting the Unique Role of the Retinoblastoma

    E-Print Network [OSTI]

    Cancer Cell Article Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has for cancer development; hence, the roles and regulation of RB have been intensively studied (reviewed

  11. BIOL10500 The Biology of Cancer Spring 2012

    E-Print Network [OSTI]

    every cell type in the body. This course will investigate how genetic and environmental factors lead to transformation of cells, how cancer cells function, the cellular systems designed to protect normal cells from becoming cancerous, and how the immune system protects against cancer. The course will examine the growth

  12. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe§ July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  13. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer ­ Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  14. A Research Agenda for Radiation Oncology: Results of the Radiation Oncology Institute's Comprehensive Research Needs Assessment

    SciTech Connect (OSTI)

    Jagsi, Reshma, E-mail: rjagsi@med.umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Bekelman, Justin E. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Brawley, Otis W. [Department of Hematology and Oncology, Emory University, and American Cancer Society, Atlanta, Georgia (United States)] [Department of Hematology and Oncology, Emory University, and American Cancer Society, Atlanta, Georgia (United States); Deasy, Joseph O. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Le, Quynh-Thu [Department of Radiation Oncology, Stanford University, Stanford, CA (United States)] [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Michalski, Jeff M. [Department of Radiation Oncology, Washington University, St. Louis, MO (United States)] [Department of Radiation Oncology, Washington University, St. Louis, MO (United States); Movsas, Benjamin [Department of Radiation Oncology, Henry Ford Health System, Detroit, MI (United States)] [Department of Radiation Oncology, Henry Ford Health System, Detroit, MI (United States); Thomas, Charles R. [Department of Radiation Oncology, Oregon Health and Sciences University, Portland, OR (United States)] [Department of Radiation Oncology, Oregon Health and Sciences University, Portland, OR (United States); Lawton, Colleen A. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)] [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)

    2012-10-01T23:59:59.000Z

    Purpose: To promote the rational use of scarce research funding, scholars have developed methods for the systematic identification and prioritization of health research needs. The Radiation Oncology Institute commissioned an independent, comprehensive assessment of research needs for the advancement of radiation oncology care. Methods and Materials: The research needs assessment used a mixed-method, qualitative and quantitative social scientific approach, including structured interviews with diverse stakeholders, focus groups, surveys of American Society for Radiation Oncology (ASTRO) members, and a prioritization exercise using a modified Delphi technique. Results: Six co-equal priorities were identified: (1) Identify and develop communication strategies to help patients and others better understand radiation therapy; (2) Establish a set of quality indicators for major radiation oncology procedures and evaluate their use in radiation oncology delivery; (3) Identify best practices for the management of radiation toxicity and issues in cancer survivorship; (4) Conduct comparative effectiveness studies related to radiation therapy that consider clinical benefit, toxicity (including quality of life), and other outcomes; (5) Assess the value of radiation therapy; and (6) Develop a radiation oncology registry. Conclusions: To our knowledge, this prioritization exercise is the only comprehensive and methodologically rigorous assessment of research needs in the field of radiation oncology. Broad dissemination of these findings is critical to maximally leverage the impact of this work, particularly because grant funding decisions are often made by committees on which highly specialized disciplines such as radiation oncology are not well represented.

  15. Gasification Research BIOENERGY PROGRAM

    E-Print Network [OSTI]

    Gasification Research BIOENERGY PROGRAM Description Researchers inthe@tamu.edu Skid-mounted gasifier: 1.8 tons-per-day pilot unit Gasification of cotton gin trash The new Texas A

  16. Photocatalysis Currently, the research

    E-Print Network [OSTI]

    Vollmer, Heribert

    Photocatalysis Currently, the research activit in the area ofies Photocatalysis focus on the topics Photocatalysis and Prof. Dr. Detlef Bahnemann Nanotechnology Research Topics Bioprocess Engineering Bioprocess Modeling and Control Photocatalysis and Nanotechnology Institute of Technical Chemistry Contact Person

  17. Effect of treatment and diet on body weight after breast cancer diagnosis : the women's healthy eating and living (WHEL) study perspective

    E-Print Network [OSTI]

    Saquib, Abu Taiyab M. N.

    2007-01-01T23:59:59.000Z

    behavioral, cancer, and treatment related variables, thoughtbehavioral, cancer, and treatment related characteristicsweight after breast cancer treatments: evidence from the

  18. University Research Summaries

    Broader source: Energy.gov [DOE]

    The Idaho National Laboratory published the U.S. Department of Energy's (DOE) Geothermal Technologies Office 2001 University Research Summaries. 

  19. Xu Zhang's Homepage - Research

    E-Print Network [OSTI]

    Research Interests. Numerical Methods for Partial Differential Equations; Finite Element and Discontinuous Galerkin Methods; Immersed Finite Element Methods

  20. Graduate Research Scholarships

    E-Print Network [OSTI]

    and Engineering Research Council of Canada Master's scholarships (17,5K, one year, non- renewable) Doctoral Research of Canada Master's scholarships (17,5K for one year, non- renewable) Doctoral scholarships (30k scholarships (20K per year, first nine semesters) Social Sciences and Humanities Research Council of Canada

  1. RESEARCH BUILDING AT NORTHWESTERN

    E-Print Network [OSTI]

    Engman, David M.

    BIOMEDICAL RESEARCH BUILDING AT NORTHWESTERN MEDICINE #12;"Our new Biomedical Research Building-intensive medical schools. Perkins+Will has designed a building that will be superbly functional and have great a magnificent 12-story Biomedical Research Building to address this priority. The new 600,000 square foot

  2. INTERNATIONAL PACIFIC RESEARCH CENTER

    E-Print Network [OSTI]

    Wang, Yuqing

    INTERNATIONAL PACIFIC RESEARCH CENTER Annual Report April 2006 ­ March 2007 School of Ocean Research Center 1 2 The Year's Highlights 3 Research Accomplishments Indo-Pacific Ocean Climate 4 Regional-Ocean Ocean Climate: To understand climate variations in the Pacific and Indian oceans on inter- annual

  3. Natural Sciences Research Outlook

    E-Print Network [OSTI]

    Sciences (July 2009), including: UK Research Councils: Biotechnology and Biological· Sciences ResearchEpARTmENT oF phySICS 14 CENTRE FoR ENVIRoNmENTAL poLICy 15 RESEARCh INSTITUTES ANd CENTRES 16 ENERGy ANd ENVIRo

  4. Researchers Edition 2014

    E-Print Network [OSTI]

    Genève, Université de

    on the thematic priorities "Translational biomedical research and medical techno- logy" and "Renewable Energy of Geneva (UNIGE). UNIGE's researchers annually obtain more than 130 million Swiss Francs, earmarked for research, from sources such as: the Swiss National Science Foundation (SNSF), the European Union (EU

  5. BRAZIL RESEARCH INITIATIVES

    E-Print Network [OSTI]

    Liu, Taosheng

    BRAZIL RESEARCH INITIATIVES Michigan State University (MSU) identifies Brazil as a global priority and challenges become increasingly part of the U.S.-Brazil agenda, MSU desires partnerships aimed at producing in the U.S. and one in Brazil, to share research strategies and explore joint projects in several research

  6. Reservoir Characterization Research Laboratory

    E-Print Network [OSTI]

    Texas at Austin, University of

    Reservoir Characterization Research Laboratory for Carbonate Studies Executive Summary for 2014 Outcrop and Subsurface Characterization of Carbonate Reservoirs for Improved Recovery of Remaining/Al 0.00 0.02 0.04 Eagle Ford Fm #12;#12; Reservoir Characterization Research Laboratory Research Plans

  7. Louisiana Transportation Research Center

    E-Print Network [OSTI]

    Harms, Kyle E.

    Louisiana Transportation Research Center LTRC www.ltrc.lsu.edu 2012-13 ANNUALREPORT #12;The Louisiana Transportation Research Center (LTRC) is a research, technology transfer, and training center administered jointly by the Louisiana Department of Transportation and Development (DOTD) and Louisiana State

  8. HR Strategy for Researchers

    E-Print Network [OSTI]

    Fabra, established in 1990, is a research-oriented, public higher education institution. UPF has of international researchers that it recruits. Consistent with this commitment to internationalization, UPF signed of Researchers (hereafter, the Charter and Code) in 2010. UPF belongs to the 3rd Cohort of the Human Resources

  9. Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer ?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of this network trying to improve the treatment of pancreatic cancer patients. Recent findings: Tarceva has the mechanisms of cell transformation and also to find appropriate targeted anti- cancer treatments. Among human in the therapeutic armamentarium against cancer raised some hopes in the treatment of patients with advanced

  10. 17/03/2006 Accepted in European Journal of Cancer Prevention Time Trends and Geographic Variations for Thyroid Cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    17/03/2006 Accepted in European Journal of Cancer Prevention 1 Time Trends and Geographic Variations for Thyroid Cancer in New Caledonia, a Very High Incidence Area (1985-1999) Thérèse Truong1 mail: guenel@vjf.inserm.fr Running head: Incidence of thyroid cancer in New Caledonia #12

  11. Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer

    E-Print Network [OSTI]

    Chen, Ming-Hui

    Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer Anthony V. D'Amico,* Ming Hui-Chen, Andrew A. Renshaw, Brenda Sussman, Kimberly A), Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, Department

  12. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  13. Research Councils UK Engaging Young

    E-Print Network [OSTI]

    Rambaut, Andrew

    Research Councils UK Engaging Young People with Cutting Edge Research: a guide for researchers to the feel-good factor researchers can have a hand in inspiring the next generation of researchers, to secure

  14. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    SciTech Connect (OSTI)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06T23:59:59.000Z

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and bismuth would be a private venture at no cost to the government. Isotek Systems, LLC, was commissioned by the DOE to execute the project, known as the 233U Disposition, Medical Isotope Production, and Building 3019 Complex Shutdown Project. Isotek is a partnership between Duratek Federal Services, Burns and Roe Enterprises, and Nuclear Fuel Services. By pooling their pioneering experiences in nuclear engineering and design, nuclear recycling, and waste management, the partnership has developed a novel process to meet this clean-up milestone. The project is not only important for its cancer treatment potential, but also for setting the stage for reducing global threats through the down-blending of materials.

  15. A self-adaptive case-based reasoning system for dose planning in prostate cancer radiotherapy

    SciTech Connect (OSTI)

    Mishra, Nishikant; Petrovic, Sanja; Sundar, Santhanam [Automated Scheduling, Optimisation and Planning Research Group, School of Computer Science, University of Nottingham, Nottingham NG8 1BB (United Kingdom); Department of Oncology, Nottingham University Hospitals NHS Trust, Nottingham NG5 1PB (United Kingdom)

    2011-12-15T23:59:59.000Z

    Purpose: Prostate cancer is the most common cancer in the male population. Radiotherapy is often used in the treatment for prostate cancer. In radiotherapy treatment, the oncologist makes a trade-off between the risk and benefit of the radiation, i.e., the task is to deliver a high dose to the prostate cancer cells and minimize side effects of the treatment. The aim of our research is to develop a software system that will assist the oncologist in planning new treatments. Methods: A nonlinear case-based reasoning system is developed to capture the expertise and experience of oncologists in treating previous patients. Importance (weights) of different clinical parameters in the dose planning is determined by the oncologist based on their past experience, and is highly subjective. The weights are usually fixed in the system. In this research, the weights are updated automatically each time after generating a treatment plan for a new patient using a group based simulated annealing approach. Results: The developed approach is analyzed on the real data set collected from the Nottingham University Hospitals NHS Trust, City Hospital Campus, UK. Extensive experiments show that the dose plan suggested by the proposed method is coherent with the dose plan prescribed by an experienced oncologist or even better. Conclusions: The developed case-based reasoning system enables the use of knowledge and experience gained by the oncologist in treating new patients. This system may play a vital role to assist the oncologist in making a better decision in less computational time; it utilizes the success rate of the previously treated patients and it can also be used in teaching and training processes.

  16. The Purdue University Center for Cancer Research is continually exploring new methods of treating cancer, techniques to detect cancer and preventative

    E-Print Network [OSTI]

    Wei, Alexander

    . Brown Mr. Donald L. Dunaway Mrs. Joyce Pahl Foley and Mr. Roger Neil Foley Mrs. Sharron S. Hillabrand. Davisson Mr. Ken C. Decker and Mrs. Kitty Decker Mr. James S. DeHaven and Mrs. Ann DeHaven Ms. Marcia L. Flynn Mrs. Sally M. Friend and Mr. James R. Friend Mrs. Bernice Heath Geiselman and Dr. Doyle Geiselman

  17. Small cell lung cancer and cancer stem cell-like cells 

    E-Print Network [OSTI]

    Sarvi, Sana

    2014-07-05T23:59:59.000Z

    Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often ...

  18. Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors

    E-Print Network [OSTI]

    Turner, Kelly Ann

    2010-01-01T23:59:59.000Z

    cancer during chemotherapy. Ann Oncol, 20(8), 1445-1446.in people with HIV/AIDS. Ann Behav Med, 24(1), 34- Ishak,biological pathways involved. Ann Oncol, 8(10), 1031-1039.

  19. Mutational heterogeneity in cancer and the search for new cancer genes

    E-Print Network [OSTI]

    Helman, Elena

    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...

  20. Argonne National Laboratory Research Highlights 1988

    SciTech Connect (OSTI)

    Not Available

    1988-01-01T23:59:59.000Z

    The research and development highlights are summarized. The world's brightest source of X-rays could revolutionize materials research. Test of a prototype insertion device, a key in achieving brilliant X-ray beams, have given the first glimpse of the machine's power. Superconductivity research focuses on the new materials' structure, economics and applications. Other physical science programs advance knowledge of material structures and properties, nuclear physics, molecular structure, and the chemistry and structure of coal. New programming approaches make advanced computers more useful. Innovative approaches to fighting cancer are being developed. More experiments confirm the passive safety of Argonne's Integral Fast Reactor concept. Device simplifies nuclear-waste processing. Advanced fuel cell could provide better mileage, more power than internal combustion engine. New instruments find leaks in underground pipe, measure sodium impurities in molten liquids, detect flaws in ceramics. New antibody findings may explain ability to fight many diseases. Cadmium in cigarettes linked to bone loss in women. Programs fight deforestation in Nepal. New technology could reduce acid rain, mitigate greenhouse effect, enhance oil recovery. Innovative approaches transfer Argonne-developed technology to private industry. Each year Argonne educational programs reach some 1200 students.