National Library of Energy BETA

Sample records for human subjects protection

  1. ORISE: Protecting Human Subjects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Protecting Human Subjects The U.S. Department of Energy (DOE) Human Subjects Research Program exists to ensure that all research conducted at DOE ...

  2. ORISE: Human Subjects Protection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) ... U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. ...

  3. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

  4. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

  5. ORISE: Human Subjects Protection Resource Protection Book

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection Resource Book The Human Subjects Protection Resource Book synthesizes information currently available on the protection of human subjects in research, the ...

  6. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

  7. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

  8. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that ...

  9. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-03-17

    The Order establishes DOE-specific policy and principles for the protection of human subjects involved in DOE research, and DOE procedures and responsibilities for implementing the policy and requirements set forth in Title 45 Code of Federal Regulations (CFR) Part 46, Protection of Human Subjects, and 10 CFR Part 745, Protection of Human Subjects. Supersedes DOE O 443.1B.

  10. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that risks to human subjects in research are minimal and to provide protection with respect to the rights and welfare of research subjects. The Oak Ridge Institute for Science and Education (ORISE) administers the Oak Ridge Sitewide Institutional Review Board (ORSIRB) and manages the ORISE Human Subjects website. The

  11. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-07-20

    Changes are made to harmonize the definitions in this Order with those in the Federal regulations for the protection of human subjects (10 CFR Part 745), specifically, splitting the definition "human subject research" into "research" and "human subject," and adopting, verbatim, the definitions of "research" and "human subject" from 10 CFR Part 745 and adding the definition of "generalizable," since the determination of whether a project is "research" in 10 CFR Part 745 hinges on whether the work being conducted is generalizable. Small corrections and updates have been made to the references, links, and organization titles.

  12. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-12-09

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Supersedes DOE O 443.1A and DOE P 443.1A.

  13. Human subjects research handbook: Protecting human research subjects. Second edition

    SciTech Connect (OSTI)

    1996-01-30

    This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

  14. Protection of Human Subjects in Classified Research

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-01-21

    This notice supplements DOE O 443.1B and 10 CFR Part 745 by addressing the Department of Energy (DOE)-specific requirements for the protection of human subjects involved in research that is classified, in whole or in part.

  15. Human Subjects Protection Program Homepage | U.S. DOE Office...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HSPP Home Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review ... Contact BER Home Contact Information Human Subjects Protection Program U.S. ...

  16. Notice of Intent to Develop Notice 443.1, Protection of Human Subjects in Classified Research

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    The purpose for developing this Notice will be to specify additional requirements for the conduct and protection of human subjects, specifically for classified research. This is necessary to ensure legal compliance with the Presidential Memorandum, Strengthened Protections for Human Subjects of Classified Research, dated March 27, 1997, commonly referred to as the "Clinton Memo," which the DOE and NNSA offices of General Counsel determined in June 2015 is still in effect and applicable to DOE federal and contractor organizations. The requirements outlined in the Clinton Memo are in addition to those specified in the Federal regulations (10 CFR Part 745) and DOE Order 443.lB, Protection of Human Research Subjects.

  17. Notice of Intent to Develop Notice 443.1, Protection of Human Subjects in Classified Research

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-03-27

    The purpose for developing this Notice will be to specify additional requirements for the conduct and protection of human subjects, specifically for classified research. This is necessary to ensure legal compliance with the Presidential Memorandum, Strengthened Protections for Human Subjects of Classified Research, dated March 27, 1997, commonly referred to as the "Clinton Memo," which the DOE and NNSA offices of General Counsel determined in June 2015 is still in effect and applicable to DOE federal and contractor organizations. The requirements outlined in the Clinton Memo are in addition to those specified in the Federal regulations (10 CFR Part 745) and DOE Order 443.lB, Protection of Human Research Subjects.

  18. DRAFT - DOE O 443.1B Chg 1, Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    Changes are made to harmonize the definitions in this Order with those in the Federal regulations for the protection of human subjects (10 CFR Part 745), specifically, splitting the definition "human subject research" into "research" and "human subject," and adopting, verbatim, the definitions of "research" and "human subject" from 10 CFR Part 745 and adding the definition of "generalizable," since the determination of whether a project is "research" in 10 CFR Part 745 hinges on whether the work being conducted is generalizable. Small corrections and updates have been made to the references, links, and organization titles.

  19. Notice of Intent to Develop a Page Change to DOE O 443.1B, Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-07-16

    The purpose of the page change is to harmonize the definitions in this Order with those in the Federal regulations for the protection of human subjects (10 CFR Part 745). Specifically, splitting the definition "human subject research" into "research" and "human subject," and adopting, verbatim, the definitions of "research" and "human subject" from 10 CFR Part 745. We also propose adding to this section the definition of "generalizable," since the determination of whether a project is "research" in 10 CFR Part 745 hinges on whether the work being conducted is generalizable. Additionally, we propose making several small corrections and updates to the references, links, and organization titles.

  20. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations ... on all research projects that involve human subjects and that are funded by DOE, ...

  1. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of information on all research projects that involve human subjects and that are funded by DOE, conducted in DOE facilities, performed by DOE personnel or involve DOE or contract personnel. The Oak Ridge Institute for Science and Education (ORISE) maintains the Human Subjects Research Database (HSRD) for the Office of

  2. Human Subjects Research Database (HSRD) | U.S. DOE Office of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database (HSRD) Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources CITI Courses DOE ...

  3. For Prospective Human Subjects | U.S. DOE Office of Science ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prospective Human Subjects Human Subjects Protection Program (HSPP) HSPP Home About For Researchers For IRB Managers Administrators For IRB Members For Institutional Officials ...

  4. The Oak Ridge Institute for Science and Education Human Subjects...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Program PrivacySecurity Statement Contact | Forms PurposeMission ... The Oak Ridge Institute for Science and Education (ORISE) Human Subjects Research Program ...

  5. Short-term Human Vision Protection from Intense Light Sources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Short-term Human Vision Protection from Intense Light Sources The primary objective of this invention is to minimize the sensitivity of the human eye to intense visible light by ...

  6. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    e p e rf n I T P V MP No. Subject: ICRF mode conversion flow drive at 8 Tesla From: Y. Lin, J. Rice, S. Wukitch, M. Reinke, N. Tsujii, Y. Podpaly, M. Greenwald, A....

  7. Report on {open_quotes}inspection of human subject research in intelligence and intelligence-related projects{close_quotes}

    SciTech Connect (OSTI)

    1996-01-16

    Executive Order 12333, {open_quotes}United States Intelligence Activities,{close_quotes} (1) designates the Department`s intelligence element as a member of the Intelligence Community, and (2) states that no agency within the Intelligence community shall sponsor, contract for or conduct research on human subjects except in accordance with guidelines issued by the Department of Health and Human Services. The Federal policy for the Protection of Human Subjects, which was based on Department of Health and Human Services regulations, was promulgated in Title 10 Code of Federal Regulations Part 745 by the Department of Energy. The purpose of this inspection was to review the internal control procedures used by the Office of Nonproliferation and National Security to manage selected intelligence and intelligence-related projects that involve human subject research.

  8. Neutron effects in humans: protection considerations

    SciTech Connect (OSTI)

    Fry, R.J.M.

    1985-01-01

    Committee I of the International Commission on Radiological Protection has recommended that the Quality Factor for neutrons should be changed from 10 to 20. This article is an interesting recount of the tale of Q from the viewpoint of an observer which illustrates many of the problems that the selection of protection standards pose. 32 refs., 5 tabs.

  9. MEMORANDUM FOR HUMAN RESOURCES DIRECTORS FROM: SUBJECT: ~~k....

    Broader source: Energy.gov (indexed) [DOE]

    2, 2011 MEMORANDUM FOR HUMAN RESOURCES DIRECTORS FROM: SUBJECT: k.--- SARAH J. B LLA, DIRECTOR OFFICE OF AN CAPITAL MANAGEMENT POLICY GUIDANCE MEMORANDUM 21 FAMILY MEMBERS The ...

  10. Creating LTS&M Efficiencies While Protecting Human Health and the Environment

    Broader source: Energy.gov [DOE]

    The Fernald Preserve environmental monitoring team implemented work efficiencies and cost savings while following their prime goal to protect human health and the environment. The team works to...

  11. U.S. Department of Energy Human Subjects Research Database (HSRD) A model for internal oversight and external transparency

    SciTech Connect (OSTI)

    Oak Ridge Institute for Science and Education

    2012-12-12

    This poster introduces the Department of Energy (DOE) Human Subjects Research Database (HSRD), which contains information on all Department of Energy research projects involving human subjects that: are funded by DOE; are conducted in DOE facilities; are performed by DOE personnel; include current or former DOE or contract personnel.

  12. DOE O 443.1B Protection of Human Research Subjects

    Office of Energy Efficiency and Renewable Energy (EERE)

    On March 17, 2011, the Department issued a Contractor Requirements Document (CRD) to the above listed Directive.

  13. MCA 22-3-801 - Human Skeletal Remains and Burial Site Protection...

    Open Energy Info (EERE)

    22-3-801 - Human Skeletal Remains and Burial Site Protection Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: MCA 22-3-801 -...

  14. Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data

    SciTech Connect (OSTI)

    Kiarashi, Nooshin; Nolte, Adam C.; Sturgeon, Gregory M.; Ghate, Sujata V.; Segars, William P.; Nolte, Loren W.; Samei, Ehsan; and others

    2015-07-15

    Purpose: Physical phantoms are essential for the development, optimization, and evaluation of x-ray breast imaging systems. Recognizing the major effect of anatomy on image quality and clinical performance, such phantoms should ideally reflect the three-dimensional structure of the human breast. Currently, there is no commercially available three-dimensional physical breast phantom that is anthropomorphic. The authors present the development of a new suite of physical breast phantoms based on human data. Methods: The phantoms were designed to match the extended cardiac-torso virtual breast phantoms that were based on dedicated breast computed tomography images of human subjects. The phantoms were fabricated by high-resolution multimaterial additive manufacturing (3D printing) technology. The glandular equivalency of the photopolymer materials was measured relative to breast tissue-equivalent plastic materials. Based on the current state-of-the-art in the technology and available materials, two variations were fabricated. The first was a dual-material phantom, the Doublet. Fibroglandular tissue and skin were represented by the most radiographically dense material available; adipose tissue was represented by the least radiographically dense material. The second variation, the Singlet, was fabricated with a single material to represent fibroglandular tissue and skin. It was subsequently filled with adipose-equivalent materials including oil, beeswax, and permanent urethane-based polymer. Simulated microcalcification clusters were further included in the phantoms via crushed eggshells. The phantoms were imaged and characterized visually and quantitatively. Results: The mammographic projections and tomosynthesis reconstructed images of the fabricated phantoms yielded realistic breast background. The mammograms of the phantoms demonstrated close correlation with simulated mammographic projection images of the corresponding virtual phantoms. Furthermore, power

  15. BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition

    SciTech Connect (OSTI)

    Brunetto de Farias, Caroline; Children's Cancer Institute, 90420-140 Porto Alegre, RS; Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS; National Institute for Translational Medicine , 90035-003 Porto Alegre, RS ; Heinen, Tiago Elias; Pereira dos Santos, Rafael; Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS; National Institute for Translational Medicine , 90035-003 Porto Alegre, RS ; Abujamra, Ana Lucia; Children's Cancer Institute, 90420-140 Porto Alegre, RS; National Institute for Translational Medicine , 90035-003 Porto Alegre, RS ; Schwartsmann, Gilberto; National Institute for Translational Medicine , 90035-003 Porto Alegre, RS; Department of Internal Medicine, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS ; and others

    2012-08-24

    Highlights: Black-Right-Pointing-Pointer BDNF protected HT-29 colorectal cancer cells from the antitumor effect of cetuximab. Black-Right-Pointing-Pointer TrkB inhibition potentiated the antitumor effect of cetuximab. Black-Right-Pointing-Pointer BDNF/TrkB signaling might be involved in resistance to anti-EGFR therapy. -- Abstract: The clinical success of targeted treatment of colorectal cancer (CRC) is often limited by resistance to anti-epidermal growth factor receptor (EGFR) therapy. The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB have recently emerged as anticancer targets, and we have previously shown increased BDNF levels in CRC tumor samples. Here we report the findings from in vitro experiments suggesting that BDNF/TrkB signaling can protect CRC cells from the antitumor effects of EGFR blockade. The anti-EGFR monoclonal antibody cetuximab reduced both cell proliferation and the mRNA expression of BDNF and TrkB in human HT-29 CRC cells. The inhibitory effect of cetuximab on cell proliferation and survival was counteracted by the addition of human recombinant BDNF. Finally, the Trk inhibitor K252a synergistically enhanced the effect of cetuximab on cell proliferation, and this effect was blocked by BDNF. These results provide the first evidence that increased BDNF/TrkB signaling might play a role in resistance to EGFR blockade. Moreover, it is possible that targeting TrkB could potentiate the anticancer effects of anti-EGFR therapy.

  16. Melatonin Protects Human Cells from Clustered DNA Damages, Killing and Acquisition of Soft Agar Growth Induced by X-rays or 970 MeV/n Fe ions

    SciTech Connect (OSTI)

    Das, B.; Sutherland, B.; Bennett, P. V.; Cutter, N. C.; Sutherland, J. C.

    2011-06-01

    We tested the ability of melatonin (N-acetyl-5 methoxytryptamine), a highly effective radical scavenger and human hormone, to protect DNA in solution and in human cells against induction of complex DNA clusters and biological damage induced by low or high linear energy transfer radiation (100 kVp X-rays, 970 MeV/nucleon Fe ions). Plasmid DNA in solution was treated with increasing concentrations of melatonin (0.0-3.5 mM) and were irradiated with X-rays. Human cells (28SC monocytes) were also irradiated with X-rays and Fe ions with and without 2 mM melatonin. Agarose plugs containing genomic DNA were subjected to Contour Clamped Homogeneous Electrophoretic Field (CHEF) followed by imaging and clustered DNA damages were measured by using Number Average length analysis. Transformation experiments on human primary fibroblast cells using soft agar colony assay were carried out which were irradiated with Fe ions with or without 2 mM melatonin. In plasmid DNA in solution, melatonin reduced the induction of single- and double-strand breaks. Pretreatment of human 28SC cells for 24 h before irradiation with 2 mM melatonin reduced the level of X-ray induced double-strand breaks by {approx}50%, of abasic clustered damages about 40%, and of Fe ion-induced double-strand breaks (41% reduction) and abasic clusters (34% reduction). It decreased transformation to soft agar growth of human primary cells by a factor of 10, but reduced killing by Fe ions only by 20-40%. Melatonin's effective reduction of radiation-induced critical DNA damages, cell killing, and striking decrease of transformation suggest that it is an excellent candidate as a countermeasure against radiation exposure, including radiation exposure to astronaut crews in space travel.

  17. The inhibitory effect of ionizing radiation on Fc and C3 receptors on mouse and human leukocytes, and the protective potential of human albumin

    SciTech Connect (OSTI)

    Herrera, M.A.; Diaz-Perches, R.; Gutierrez, M.; Gamminio, E.; Liera, C.; Nieto, P.; Weiss-Steider, B. )

    1990-08-01

    The effect that ionizing radiation has in vitro on Fc and C3 receptors was evaluated at various doses and measured by means of erythrocytes coated with antibody (EA) and erythrocytes coated with antibody and complement (EAC) rosettes on human peripheral blood leukocytes (PBL) and on mouse bone marrow cells (BMC) and PBL. We found that the number of cells with either EA and EAC rosettes decreased as the radiation doses increased, and that they were almost absent when the highest doses were employed. We obtained evidence that albumin is a natural source of radio-protection for Fc and C3 receptors, and we showed that by increasing the amount of this molecule we could completely protect receptors for EA and EAC in vitro. Finally, the possible therapeutic value of the administration of human albumin to patients undergoing radiotherapy is discussed.

  18. Subject Guides

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Subject Guides Choose your subject area to find relevant resources. Business Chemistry Computer Science Data Management Earth & Environmental Science Engineering Global Security ...

  19. Protections: Sampling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protections: Sampling Protections: Sampling Protection #3: Sampling for known and unexpected contaminants August 1, 2013 Monitoring stormwater in Los Alamos Canyon Monitoring stormwater in Los Alamos Canyon The Environmental Sampling Board, a key piece of the Strategy, ensures that LANL collects relevant and appropriate data to answer questions about the protection of human and environmental health, and to satisfy regulatory requirements. LANL must demonstrate the data are technically justified

  20. A Multidisciplinary Paradigm and Approach to Protecting Human Health and the Environment, Society, and Stakeholders at Nuclear Facilities - 12244

    SciTech Connect (OSTI)

    Burger, Joanna; Gochfeld, Michael; Clarke, James; Powers, Charles W.; Kosson, David

    2012-07-01

    As the Department of Energy (DOE) continues to remediate its lands, and to consider moving toward long-term stewardship and the development of energy parks on its industrial, remediated land, it is essential to adequately characterize the environment around such facilities to protect society, human health, and the environment. While DOE sites re considering several different land-use scenarios, all of them require adequate protection of the environment. Even if DOE lands are developed for energy parks that are mainly for industrializes sections of DOE lands that will not be remediated to residential standards, there is still the need to consider the protection of human health and the environment. We present an approach to characterization and establishment of teams that will gather the information, and integrate that information for a full range of stakeholders from technical personnel, to public policy makers, and that public. Such information is needed to establish baselines, site new energy facilities in energy parks, protect existing nuclear facilities and nuclear wastes, improve the basis for emergency planning, devise suitable monitoring schemes to ensure continued protection, provide data to track local and regional response changes, and for mitigation, remediation and decommissioning planning. We suggest that there are five categories of information or data needs, including 1) geophysical, sources, fate and transport, 2) biological systems, 3) human health, 4) stakeholder and environmental justice, and 5) societal, economic, and political. These informational needs are more expansive than the traditional site characterization, but encompass a suite of physical, biological, and societal needs to protect all aspects of human health and the environment, not just physical health. We suggest a Site Committee be established that oversees technical teams for each of the major informational categories, with appropriate representation among teams and with a broad

  1. Effects of wearing protective chemical warfare-combat clothing on human performance. Final report, Sep 89-Aug 91

    SciTech Connect (OSTI)

    Taylor, H.L.; Orlansky, J.

    1991-08-01

    U.S. Department of Defense studies to measure performance decrements associated with wearing chemical warfare (CW) protective combat clothing indicate that heat stress produced seriously degraded human performance. Even when heat stress is not a significant factor, performance of many combat, combat support, and combat service support tasks is degraded. In most field studies, many crews of combat units became operationally ineffective due to voluntary withdrawal of individual crew members. Many combined arms, field studies, and laboratory studies indicate that when CW-protective combat clothing is worn performance is seriously degraded for (1) the detection of targets, engagement time, accuracy of fire, and (2) manual dexterity tasks; and that (3) a variety of psychological effects are created. Further, the degree of performance degradation varied with the tasks performed. Training in CW-protective combat clothing permits learning to modify procedures and consequently reduce negative effects, provided heat stress is not a significant factor. A growing body of evidence indicates there is inadequate training in the use of CW-protective combat clothing. A critical need exists for more and better training of skills needed under CW conditions.

  2. MEMORANDUM SUBJECT:

    Office of Legacy Management (LM)

    Control 0 AECMED managed operations 0 AECMED responsible for accountability 0 AEWMED overviewed operationr 0 Contractor had total control 0 unknown 17 Health Physics Protection 0 ...

  3. Study of air pollution: Effects of ozone on neuropeptide-mediated responses in human subjects. Final report

    SciTech Connect (OSTI)

    Boushey, H.A.

    1991-11-01

    The study examined the hypothesis that ozone inactivates the enzyme, neutral endopeptidase, responsible for limiting the effects of neuropeptides released from afferent nerve endings. Cough response of capsaicin solution delivered from a nebulizer at 2 min. intervals until two or more coughs were produced. Other endpoints measured included irritative symptoms as rated by the subjects on a nonparametric scale, spirometry, of each concentration of ozone were compared to those of filtered air in a single-blind randomized sequence. The results indicate that a 2 h. exposure to 0.4 ppm of ozone with intermittent light exercise alters the sensitivity of airway nerves that mediate the cough response to inhaled materials. This dose of ozone also caused a change in FEV1. A lower level of ozone, 0.02 ppm, caused a change in neither cough threshold nor FEV1, even when the duration of exposure was extended to three hours. The findings are consistent with the author's hypothesis that ozone may sensitize nerve endings in the airways by inactivating neutral endopeptidase, an enzyme that regulates their activity, but they do not demonstrate that directly examining an effect directly mediated by airway nerves allows detection of effects of ozone at doses below those causing effects detected by standard tests of pulmonary function.

  4. HEHORANDUU SUBJECT:

    Office of Legacy Management (LM)

    OWNED ngCMED INVOLVEMENT.AT SITE ---------------- kontrol 0 Health Physics Protection ' 0 AEWMED managed operatiOnS q Little or None 0 AECllED responsible for (-j ...

  5. Protection against 2-chloroethyl ethyl sulfide (CEES) - induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway

    SciTech Connect (OSTI)

    Abel, Erika L.; Bubel, Jennifer D.; Simper, Melissa S.; Powell, Leslie; McClellan, S. Alex; Andreeff, Michael; MacLeod, Michael C.; DiGiovanni, John

    2011-09-01

    Sulfur mustard (SM or mustard gas) was first used as a chemical warfare agent almost 100 years ago. Due to its toxic effects on the eyes, lungs, and skin, and the relative ease with which it may be synthesized, mustard gas remains a potential chemical threat to the present day. SM exposed skin develops fluid filled bullae resulting from potent cytotoxicity of cells lining the basement membrane of the epidermis. Currently, there are no antidotes for SM exposure; therefore, chemopreventive measures for first responders following an SM attack are needed. Glutathione (GSH) is known to have a protective effect against SM toxicity, and detoxification of SM is believed to occur, in part, via GSH conjugation. Therefore, we screened 6 potential chemopreventive agents for ability to induce GSH synthesis and protect cultured human keratinocytes against the SM analog, 2-chloroethyl ethyl sulfide (CEES). Using NCTC2544 human keratinocytes, we found that both sulforaphane and methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) stimulated nuclear localization of Nrf2 and induced expression of the GSH synthesis gene, GCLM. Additionally, we found that treatment with CDDO-Me elevated reduced GSH content of NCTC2544 cells and preserved their viability by {approx} 3-fold following exposure to CEES. Our data also suggested that CDDO-Me may act additively with 2,6-dithiopurine (DTP), a nucleophilic scavenging agent, to increase the viability of keratinocytes exposed to CEES. These results suggest that CDDO-Me is a promising chemopreventive agent for SM toxicity in the skin. - Highlights: > CDDO-Me treatment increased intracellular GSH in human keratinocytes. > CDDO-Me increased cell viability following exposure to the half-mustard, CEES. > The cytoprotective effect of CDDO-Me was likely due to scavenging with endogenous GSH.

  6. Human papillomavirus types detected in skin warts and cancer differ in their transforming properties but commonly counteract UVB induced protective responses in human keratinocytes

    SciTech Connect (OSTI)

    Shterzer, Naama; Heyman, Dariya; Shapiro, Beny; Yaniv, Abraham; Jackman, Anna; Serour, Francis; Chaouat, Malka; Gonen, Pinhas; Tommasino, Massimo; Sherman, Levana

    2014-11-15

    In the present study, E6E7 and E6 proteins of human papillomaviruses (HPVs) associated with skin warts and cancer were compared for their transforming and carcinogenic abilities in primary human keratinocytes (PHKs). We show that E6E7 of cancer associated beta HPV types, notably 49 and 24, were able to extend the life span and enhance the clonogenic efficiency of PHKs when maintained in serum free/low calcium medium. Activities of the beta HPV E6E7 were lower than those of HPV16 E6E7. In contrast, E6 proteins from HPV types detected in skin warts or cancer, notably 10, 49 and 38, attenuated UVB induced protective responses in PHKs including cell death, proliferation arrest and accumulation of the proapoptotic proteins, p53, bax or bak. Together, this investigation revealed functional differences and commonalities between HPVs associated with skin warts and cancer, and allowed the identification of specific properties of beta HPVs supporting their involvement in skin carcinogenesis. - Highlights: • Primary keratinocytes were used to evaluate transforming and carcinogenic abilities of cutaneous HPVs. • E6E7 of cancer associated β HPV types transform primary human keratinocytes. • E6 proteins of cancer and wart associated HPVs inhibit UVB induced cell death. • E6s of cancer and wart associated HPVs attenuate UVB induced proliferation arrest. • E6s of cancer and wart associated HPVs attenuate UVB induced apoptosis signaling.

  7. Zinc protects human peripheral blood lymphocytes from Cr(III)(phenanthroline){sub 3}-induced apoptosis

    SciTech Connect (OSTI)

    Sankaramanivel, Sundararaj; Rajaram, Anantanarayanan; Rajaram, Rama

    2010-03-15

    We have studied the effect of Cr(III)(phen){sub 3} [(tris(1,10-phenanthroline) chromium(III) chloride)] on lymphocytes in order to find out if metallothioneins (MTs) are produced in the process. We also investigated whether zinc pretreatment is able to protect cells from apoptosis reported to occur for this compound. Our results indicate that MT synthesis is induced by Cr(III)(phen){sub 3}, and it has been identified as the MT-3 isoform through RT-PCR which has not been reported earlier. By zinc pretreatment, this apoptosis is reversed as inferred from cytotoxicity studies, Annexin-V/PI staining, ethidium bromide/acridine orange staining and DNA fragmentation pattern and ultrastructural investigations using TEM and SEM. The zinc pretreatment reduces the amount of ROS produced by Cr(III)(phen){sub 3} . The MT-1a and 1b synthesized by zinc (also evidenced through RT-PCR experiments) is possibly able to scavenge ROS which is one of the early signaling molecules that lead to apoptosis. Zinc pretreatment also reverses the changes in downstream signaling events such as mitochondrial membrane potential, ATP levels and the activation of caspase-3. This is the first report on the induction of MT-3 in lymphocytes due to a metal stress or any other stimuli. Even though MT-3 is synthesized here, apoptosis still occurs due to ROS production on Cr(III)(phen){sub 3} exposure when the cells have not been primed with zinc.

  8. Los Alamos Science: Number 23, 1995. Radiation protection and the human radiation experiments

    SciTech Connect (OSTI)

    Cooper, N.G.

    1995-12-31

    There are a variety of myths and misconceptions about the ionizing radiation that surrounds and penetrates us all. Dispel a few of these by taking a leisurely tour of radiation and its properties, of the natural and man-made sources of ionizing radiation, and of the way doses are calculated. By damaging DNA and inducing genetic mutations, ionizing radiation can potentially initiate a cell on the road to cancer. The authors review what is currently known about regulation of cellular reproduction, DNA damage and repair, cellular defense mechanisms, and the specific cancer-causing genes that are susceptible to ionizing radiation. A rapid survey of the data on radiation effects in humans shows that high radiation doses increase the risk of cancer, whereas the effects of low doses are very difficult to detect. The hypothetical risks at low doses, which are estimated from the atomic-bomb survivors, are compared to the low-dose data so that the reader can assess the present level of uncertainty. As part of the openness initiative, ten individuals who have worked with plutonium during various periods in the Laboratory`s history were asked to share their experiences including their accidental intakes. The history and prognosis of people who have had plutonium exposures is discussed by the Laboratory`s leading epidemiologist.

  9. HEHORANDUU SUBJECT:

    Office of Legacy Management (LM)

    HEHORANDUU SUBJECT: .I CILTERNATE Pastr________________________ Current:~ -------------------_______ Owner contacted q yes anof if yes, dets contacted IKLE-!PEE_nILm! q Research & Development 0 Production scale testing 0 Pilot Scale q Bench Scale Process 0 Theoretical Studies 0 Sample & Analysis 0 Product i on 0 Disposal/Storage .u Facility Type 0 Uanufacturing q University 0 Research Organization 0 ' Government Sponsored Facility 0 Other --------------------- 0 Prime cl 0

  10. MEMORANDUM SUBJECT:

    Office of Legacy Management (LM)

    SUBJECT: -------------STATE: --g--L "EEE;;' fi*J- \ . _ _ -----2-Y Owner contacted Q y&a Hno; if yes, date contacted _ ur MPf. co. Current: ---------------------~~~~~ ----- / 0 Production scale testing 0 Pilot Scale 0 Bench Scale Process 0 Studies Theoretical Cl 84 a Sample Analysis ~~p+-md-AI 0 Production I2 Disposal/Storage 0 Facility Type 0 Research Organization 0 Government Sponsored Facility 0 Other ~~~~~~~~------_------ 0 Prime 0 0 Subcontract& Other information (i.e., cost +

  11. Nanocomposite protective coatings for battery anodes (Patent...

    Office of Scientific and Technical Information (OSTI)

    Nanocomposite protective coatings for battery anodes Title: Nanocomposite protective ... USDOE Country of Publication: United States Language: English Subject: 25 ENERGY STORAGE

  12. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  13. Optimization of radiation protection: a bibliography

    SciTech Connect (OSTI)

    Tang, G.R.; Khan, T.A.; Sullivan, S.G.

    1996-10-01

    This document provides a bibliography of radiation protection optimization documents. Abstracts, an author index, and a subject index are provided.

  14. The original of this document contains information which is subject...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... reliability, trustworthiness and ability to protect classified information. ... Instead, recognizing the complexities of human nature, Administrative Judges apply the ...

  15. Standard Subject Classification System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1979-08-14

    The order establishes the DOE Standard Subject Classification System for classifying documents and records by subject, including correspondence, directives, and forms.Cancels DOE O 0000.1.

  16. Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

    SciTech Connect (OSTI)

    Bukreyev, Alexander Marzi, Andrea; Feldmann, Friederike; Zhang Liqun; Dorward, David W.; Pickles, Raymond J.; Feldmann, Heinz; Collins, Peter L.

    2009-01-20

    We generated a new live-attenuated vaccine against Ebola virus (EBOV) based on a chimeric virus HPIV3/{delta}F-HN/EboGP that contains the EBOV glycoprotein (GP) as the sole transmembrane envelope protein combined with the internal proteins of human parainfluenza virus type 3 (HPIV3). Electron microscopy analysis of the virus particles showed that they have an envelope and surface spikes resembling those of EBOV and a particle size and shape resembling those of HPIV3. When HPIV3/{delta}F-HN/EboGP was inoculated via apical surface of an in vitro model of human ciliated airway epithelium, the virus was released from the apical surface; when applied to basolateral surface, the virus infected basolateral cells but did not spread through the tissue. Following intranasal (IN) inoculation of guinea pigs, scattered infected cells were detected in the lungs by immunohistochemistry, but infectious HPIV3/{delta}F-HN/EboGP could not be recovered from the lungs, blood, or other tissues. Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV.

  17. material protection

    National Nuclear Security Administration (NNSA)

    %2A en Office of Weapons Material Protection http:www.nnsa.energy.govaboutusourprogramsnonproliferationprogramofficesinternationalmaterialprotectionandcooperation-1

  18. material protection

    National Nuclear Security Administration (NNSA)

    %2A en Office of Weapons Material Protection http:nnsa.energy.govaboutusourprogramsnonproliferationprogramofficesinternationalmaterialprotectionandcooperation-1

  19. Standard Subject Classification System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1978-07-19

    The order establishes the Department of Energy (DOE) Standard Subject Classification System for classifying documents and records by subject, including correspondence, directives, and forms. Canceled by DOE O 0000.1A.

  20. A C-terminal Hydrophobic, Solvent-protected Core and a Flexible N-terminus are Potentially Required for Human Papillomavirus 18 E7 Protein Functionality

    SciTech Connect (OSTI)

    Liu, S.; Tian, Y; Greenaway, F; Sun, M

    2010-01-01

    The oncogenic potential of the high-risk human papillomavirus (HPV) relies on the expression of genes specifying the E7 and E6 proteins. To investigate further the variation in oligomeric structure that has been reported for different E7 proteins, an HPV-18 E7 cloned from a Hispanic woman with cervical intraepithelial neoplasia was purified to homogeneity most probably as a stable monomeric protein in aqueous solution. We determined that one zinc ion is present per HPV-18 E7 monomer by amino acid and inductively coupled plasma-atomic emission spectroscopy analysis. Intrinsic fluorescence and circular dichroism spectroscopic results indicate that the zinc ion is important for the correct folding and thermal stability of HPV-18 E7. Hydroxyl radical mediated protein footprinting coupled to mass spectrometry and other biochemical and biophysical data indicate that near the C-terminus, the four cysteines of the two Cys-X{sub 2}-Cys motifs that are coordinated to the zinc ion form a solvent inaccessible core. The N-terminal LXCXE pRb binding motif region is hydroxyl radical accessible and conformationally flexible. Both factors, the relative flexibility of the pRb binding motif at the N-terminus and the C-terminal metal-binding hydrophobic solvent-protected core, combine together and facilitate the biological functions of HPV-18 E7.

  1. TO: FROM: SUBJECT,

    Office of Legacy Management (LM)

    accountability *AECMED overviewed operations FContractor had total control unknown Physics Protection 1 Little or None mECMED responsibility SC Contractor responsibility ...

  2. MEMORANDUM SUBJECT8

    Office of Legacy Management (LM)

    Control 0 Health Physics Protection 0 AECMED managed operations 0 Little or None 0 AECHED responsible for pECMED responsibility * accountability wontractor responsibility AEC...

  3. protective force

    National Nuclear Security Administration (NNSA)

    ntex%20-%20protective%20force%20-%20edited.jpg" alt"successfully completed a recent assessment by the U.S. Department " >

    Members of Pantex's Protective Force on...

  4. MEMORANDUM TO: FROM: SUBJECT:

    Broader source: Energy.gov (indexed) [DOE]

    TO: FROM: SUBJECT: Department of Energy Washington, DC 20585 May 29,2014 ADAM SIEMINSKI ADMINISTRATOR ENERGY INFORMATION ADMINISTON CHRISTOPHER SMITH v- PRINCIPAL DEPUTY ...

  5. MEHORANDUfl TO: FILE SUBJECT:

    Office of Legacy Management (LM)

    Physics Protection 0 AECnED managed operation5 c Little ar None G AECMED responsible far c AECtlED responsibility accountability c Contractoi'respansibility c AECMED overviewed ...

  6. Protecting Wildlife

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Wildlife Protecting Wildlife We monitor and protect the wildlife and their habitats on Laboratory property. February 2, 2015 Mule deer on LANL property LANL has been home to mule deer since its creation in 1942 and has seasonally been home to elk since their reintroduction to New Mexico in the 1960s. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Protecting our wildlife Since the early 1940s, LANL's

  7. Protections: Sampling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection 3: Sampling for known and unexpected contaminants August 1, 2013 Monitoring stormwater in Los Alamos Canyon Monitoring stormwater in Los Alamos Canyon The Environmental ...

  8. SUBJECT: OWNER(S)

    Office of Legacy Management (LM)

    HEHORANDUH ;;&; DC&b ------w--v SUBJECT: OWNER(S) ---... P1st a Owner contrctmd TYPE OF ... (i.e., comt -w-e--- ContrrctPurchrsa Order 0 CONTRACTING PERIOD: ---... . ...

  9. PS-6 SUbject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Larson.Cheryl A - PS-6 SUbject: annexed load treatment in RD ROD (p32-33) and Ex B oftemplates -----Original Message----- From: Randy Gregg mailto:GREGGR@bentonpud.org Sent:...

  10. Fire Protection

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-05

    This Standard was developed to provide acceptable methods and approaches for meeting DOE fire protection program and design requirements and to address special or unique fire protection issues at DOE facilities that are not comprehensively or adequately addressed in national consensus standards or other design criteria.

  11. Protective Force

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-08-26

    Establishes requirements for management and operation of the DOE Protective Force (PF), establishes requirements for firearms operations and defines the firearms courses of fire. Cancels: DOE M 473.2-1A DOE M 473.2-2

  12. Fire Protection

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... room application. (Refer to NFPA 318, Standard for the Protection of Semiconductor Fabrication Facilities.) See also Appendix A of DOE-STD-1066-99 for information on other types ...

  13. Corrosion protection

    DOE Patents [OSTI]

    Brown, Donald W.; Wagh, Arun S.

    2003-05-27

    There has been invented a chemically bonded phosphate corrosion protection material and process for application of the corrosion protection material for corrosion prevention. A slurry of iron oxide and phosphoric acid is used to contact a warm surface of iron, steel or other metal to be treated. In the presence of ferrous ions from the iron, steel or other metal, the slurry reacts to form iron phosphates which form grains chemically bonded onto the surface of the steel.

  14. Protective Force

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-03-07

    The manual establishes requirements for management and operation of the DOE Protective Force, establishes requirements for firearms operations and defines the firearms courses of fire. Chg 1 dated 3/7/06. DOE M 470.4-3A cancels DOE M 470.4-3, Chg 1, Protective Force, dated 3-7-06, Attachment 2, Contractor Requirement Document (CRD) only (except for Section C). Chg 1, dated 3-7-06, cancels DOE M 470.4-3

  15. Physical Protection

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-08-26

    This Manual establishes requirements for the physical protection of safeguards and security interests. Copies of Section B, Safeguards and Security Alarm Management System, which contains Unclassified Controlled Nuclear Information, and Appendix 1, Security Badge Specifications, which contains Official Use Only information, are only available, by request, from the program manager, Protection Program Operations, 301-903-6209. Chg 1, dated 3/7/06. Cancels: DOE M 473.1-1 and DOE M 471.2-1B

  16. Physical Protection

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-08-26

    Establishes requirements for the physical protection of safeguards and security interests. Copies of Section B, Safeguards and Security Alarm Management System, which contains Unclassified Controlled Nuclear Information, and Appendix 1, Security Badge Specifications, which contains Official Use Only information, are only available, by request, from the program manager, Protection Program Operations, 301-903-6209. Cancels: DOE M 473.1-1 and DOE M 471.2-1B.

  17. MEMORANDUM TO: FROM: SUBJECT:

    U.S. Energy Information Administration (EIA) Indexed Site

    TO: FROM: SUBJECT: Department of Energy Washington, DC 20585 May 29,2014 ADAM SIEMINSKI ADMINISTRATOR ENERGY INFORMATION ADMINIST~ON CHRISTOPHER SMITH ~v- PRINCIPAL DEPUTY ASSISTANT SECRETARY OFFICE OF FOSSIL ENERGY Request for an Update ofEIA's January 2012 Study of Liquefied Natural Gas Export Scenarios The Office of Fossil Energy (FE) requests the Energy Infmmation Administration (EIA) to evaluate the impact of increased natural gas demand, reflecting possible exports of U.S. natural gas, on

  18. TO: FROM: SUBJECT,

    Office of Legacy Management (LM)

    TO: FROM: SUBJECT, tlEMORANDUtl DATE --w--s CSLTERNATE . NAME: ---------------------- OWNER(S) ---v--w- Pamt a ------------------------ Current: ------------------------- Owner contacted 0 yes nno; if yes, date contacted ------------- TYPE OF OPERATION ----------------- werearch P Development 6 Production scale testing 0 Pilot Scale 0 Bench Sea10 Process 0 Theoretical Studies 0 Sample & Analysis 0 Production 0 Disposal/Storage TYPE OF CONTRC4CT ---------------- 0 Prime ubcontractor Purchase

  19. Physical protection

    SciTech Connect (OSTI)

    Myre, W.C.; DeMontmollin, J.M. )

    1989-07-01

    Serious concern about physical protection of nuclear facilities began around 1972. R and D was initiated at Sandia National Laboratories which had developed techniques to protect weapons for many years. Special vehicles, convoy procedures, and a communications system previously developed for weapons shipments were improved and extended for shipments of other sensitive materials. Barriers, perimeter alarms, portal and internal control systems were developed, tested, and published in handbooks and presented at symposia. Training programs were initiated for U.S. and foreign personnel. Containment and surveillance techniques were developed for the IAEA. Presently emphasis is on computer security, active barriers, and techniques to prevent theft or sabotage by insiders .

  20. weapons material protection | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    material protection

  1. Physical Protection

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-07-23

    This Manual establishes requirements for the physical protection of interests under the U.S. Department of Energys (DOEs) purview ranging from facilities, buildings, Government property, and employees to national security interests such as classified information, special nuclear material (SNM), and nuclear weapons. Cancels Section A of DOE M 470.4-2 Chg 1. Canceled by DOE O 473.3.

  2. Environmental Protection Division (ENV)

    National Nuclear Security Administration (NNSA)

    e~Alamos NATIONAL LABORATORY - - l :il . l! IIJ - - Environmental Protection Division (ENV) Environmental Stewardship (ENV-ES) P.O. Box 1663, Mail Stop J978 Los Alamos, New Mexico 87545 (505) 665-8855/FAX: (505) 667-0731 Mr. George Rael Assistant Manager for Enviromnental Operations National Nuclear Security Administration Los Alamos Site Office, MS A316 Date : October 28, 2010 Refer To: ENV-ES: 10-211 SUBJECT: 2008 SITE-WIDE ENVIRONMENTAL IMP ACT STATEMENT MITIGATION ACTION PLAN ANNUAL REPORT

  3. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    SCIENCE FREEDOM OF INFORMATION ACT HISTORICAL ASPECTS LOS ALAMOS RESEARCH PROGRAMS WEAPONS SECRECY PROTECTION The secrecy required by nuclear research during the Second...

  4. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Radioactive decay data tables Kocher D C RADIATION PROTECTION AND DOSIMETRY RADIOISOTOPES DECAY ACCURACY DATA COMPILATION DOSIMETRY M CODES COMPUTER CODES DATA INFORMATION ISOTOPES...

  5. MEMORANDU TO: FILE FHOM: SUBJECT:

    Office of Legacy Management (LM)

    1 .., ' . AECMED INVOLVEMENT AT SITE ----------------- Control q Health Physics Protection ' 0 AEWMED managed operations r Little or None 0 AECMED responsible for c ...

  6. Q MEtlORANDUM SUBJECT:

    Office of Legacy Management (LM)

    AECMED INVOLVEMENT AT SITE -...---... ------ . , Control 0 Health Physics Protection 0 AEWMED managed operations (J Little or None 0 AEWMED responsible for -ECNED ...

  7. TO: FILE FROM: I SUBJECT:

    Office of Legacy Management (LM)

    AECMED INVOLVEMMT AT SITE ----------- Control 3 Health Physics Protection ' 0 AECMED managed operations 0 Little or None Cl AECfMED responsible for ...

  8. Waters LANL Protects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waters LANL Protects Waters LANL Protects LANL watersheds source in the Jemez Mountains and end at the Rio Grande.

  9. U.S. Environmental Protection Agency | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The mission of the Environmental Protection Agency (EPA) is to protect human health and the environment. EPA achieves this by keeping pollution out of the air we breathe, the water ...

  10. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    plasma current of 0.8 MA and 0.8 MW ICRF heating. Shot1100827030 was a 0.8 MA, 5.5 tesla discharges that exhibited a clear WCM on the 88 GHz reflectometer channel (Fig. 2)...

  11. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    heat-flux width scaling investigation (see Fig. 1). We will fix the toroidal field (5.4 tesla) and scan plasma current and density. Fig. 1 - This mini-proposal will revisit a...

  12. Subject:

    Broader source: Energy.gov (indexed) [DOE]

    BY REFERENCE Delete OR Contract Administrator in sentence four. CLAUSE 6 - COST ACCOUNTING STANDARDS (CAS) LIABILITY 1. Remove all Italicized words. 2. Change Subtitle to...

  13. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rotation reversals, poloidal impurity asymmetries and "non-local" heat transport Gao thesis 2015, Rice NF 2013). We are not yet certain if our RF L-mode target plasmas will...

  14. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    across the transition from an I- mode to an ELM-free H-mode, examining the time evolution of both impurity and main- ion densities. The primary goal is a search for a solid...

  15. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    radiated power H-mode experiments in Alcator C-Mod and consequences for International Thermonuclear Experimental Reactor (ITER) QDT 10 operation. Physics of Plasmas,...

  16. SUBJECT:

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... a violation of a law, rule or regulation; gross mismanagement; gross waste of funds; an abuse of authority; or a substantial and specific danger to public health or safety. ...

  17. Subject:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of partially-ionized low-Z impurities. This will allow us to make direct connection between the emitting charge states seen by the VUV spectroscopy and the radiated power...

  18. Executive Order 11514: Protection and Enhancement of Environmental...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Federal Government shall provide leadership in protecting and enhancing the quality of the Nation's environment to sustain and enrich human life. Federal agencies shall ...

  19. Executive Order 11514: Protection and Enhancement of Environmental Quality

    Broader source: Energy.gov [DOE]

    The Federal Government shall provide leadership in protecting and enhancing the quality of the Nation's environment to sustain and enrich human life. Federal agencies shall initiate measures needed...

  20. EO 11514: Protection and Enhancement of Environmental Quality (1970)

    Broader source: Energy.gov [DOE]

    The Federal Government shall provide leadership in protecting and enhancing the quality of the Nation's environment to sustain and enrich human life. Federal agencies shall initiate measures needed...

  1. BLM Manual 8140 - Protecting Cultural Resources | Open Energy...

    Open Energy Info (EERE)

    section provides general guidance for protecting cultural resources from natural or human-caused deterioration; for making decisions about recovering significant cultural...

  2. EO 11514: Protection and Enhancement of Environmental Quality

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Federal Government shall provide leadership in protecting and enhancing the quality of the Nation's environment to sustain and enrich human life. Federal agencies shall ...

  3. PROTECTIVE CLOTHING BASED ON PERMSELECTIVE MEMBRANE AND CARBON ADSORPTION

    SciTech Connect (OSTI)

    J.G. Wijmans; J.O. Stull

    2001-11-07

    . Protective suits were prepared in collaboration with Kimberly-Clark Corporation and heat stress testing with human test subjects was carried out by the International Union of Operating Engineers (IUOE). The tests confirmed that the MTR protective fabric is significantly more comfortable than non-breathable materials. A cost analysis was developed from the properties of the optimized protective fabric and the results of the of the IUOE field study to determine the potential for the MTR material technology within the chemical protective clothing market. A detailed assessment of the specific chemical protective clothing applications for which the material can be used and its competitiveness with existing material technology, based both on expected performance and material/end item costs, was prepared. Three specific market opportunities identified for the novel protective fabric are: (1) liquid splash protective clothing for hazardous waste site operations, (2) liquid splash protective clothing for emergency response, and (3) Class 3 NFPA 1994-compliant protective clothing for civilian use during chemical terrorism incidents.

  4. Protections = Defenses in Depth

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protections: Cleanup Cleanup 101 Corrective Measures Process Protection 1: Remove the Source Example Cleanup: Removal of Polychlorinated Biphenyls from Hillside 140 Environmental ...

  5. Office of Physical Protection

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Office of Physical Protection is comprised of a team of security specialists engaged in providing Headquarters-wide physical protection.

  6. Model Fire Protection Program

    Broader source: Energy.gov [DOE]

    This program demonstrates acceptable methods and examples to assist each DOE site in meeting the fire protection objectives provided in DOE Order 5480.7A, "Fire Protection."

  7. Fire Protection Program

    Broader source: Energy.gov [DOE]

    Department of Energy (DOE) Fire Protection Program provides published fire safety directives (orders, standards, and guidance documents), a range of oversight activities, an annual fire protection program summary.

  8. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    study of the draft handbook for human reliability analysis with emphasis on nuclear power plant applications NUREG CR Brune R L Weinstein M Fitzwater M E SPECIFIC NUCLEAR REACTORS...

  9. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Jason C Pohl Kenneth Roy Mickel Patrick R Lohn Andrew Marinella Matthew The human brain volume cm3 consumes W and is capable of performing E16 operations s Current...

  10. Voluntary Protection Program | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Voluntary Protection Program

  11. MEMORANDU TO: FILE FHOM: SUBJECT:

    Office of Legacy Management (LM)

    ' .- _. I _ ' 1.3 7 -3 , MEMORANDU TO: FILE FHOM: SUBJECT: Curre"t: Ll&k&&d ________ l- ; if yes, date contacted ___ 0 Production scale testing Cl Pilot Scale 0 Bench Scale Process 0 Theoretical Studies 0 Sample & Analysis 0 Production 0 Disposal /Storage TYPE OF CONTRACT --------------_- 0 Prime 13 Subcontract& 0 Purchase Order 0 Cl Facility Type 0 Manufacturing 0 University 0 Research Organization *i Government Sponsored Facility 0 Other --------------_-----_ Other

  12. Voluntary Protection Program Announcement

    Broader source: Energy.gov [DOE]

    Secretary O'Leary formally announced a new initiative, "The Department of Energy Voluntary Protection Program (DOEVPP)," which is designed to recognize contractor sites that are providing excellent safety and health protection to their employees.

  13. Protective Force Program Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-06-30

    Provides detailed requirements to supplement DOE O 473.2, Protective Force Program, which establishes the requirements and responsibilities for management and operation of the Department of Energy (DOE) Protective Force (PF) Program. Does not cancel other directives.

  14. Protection Program Operations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-10-14

    This Order establishes requirements for the management and operation of the Department of Energy (DOE) Federal Protective Forces (FPF), Contractor Protective Forces (CPF), and the Physical Security of property and personnel under the cognizance of DOE.

  15. Fire Protection Program Metrics

    Broader source: Energy.gov [DOE]

    Presenter: Perry E. D ’Antonio, P.E., Acting Sr. Manager, Fire Protection - Sandia National Laboratories

  16. Model Fire Protection Program

    Broader source: Energy.gov [DOE]

    To facilitate conformance with its fire safety directives and the implementation of a comprehensive fire protection program, DOE has developed a number of "model" program documents. These include a comprehensive model fire protection program, model fire hazards analyses and assessments, fire protection system inspection and testing procedures, and related material.

  17. Corium protection assembly

    DOE Patents [OSTI]

    Gou, Perng-Fei; Townsend, Harold E.; Barbanti, Giancarlo

    1994-01-01

    A corium protection assembly includes a perforated base grid disposed below a pressure vessel containing a nuclear reactor core and spaced vertically above a containment vessel floor to define a sump therebetween. A plurality of layers of protective blocks are disposed on the grid for protecting the containment vessel floor from the corium.

  18. Fire Protection Program Manual

    SciTech Connect (OSTI)

    Sharry, J A

    2012-05-18

    This manual documents the Lawrence Livermore National Laboratory (LLNL) Fire Protection Program. Department of Energy (DOE) Orders 420.1B, Facility Safety, requires LLNL to have a comprehensive and effective fire protection program that protects LLNL personnel and property, the public and the environment. The manual provides LLNL and its facilities with general information and guidance for meeting DOE 420.1B requirements. The recommended readers for this manual are: fire protection officers, fire protection engineers, fire fighters, facility managers, directorage assurance managers, facility coordinators, and ES and H team members.

  19. Research Subject Areas for IGPPS Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Subject Areas Research Subject Areas for IGPPS Proposals High quality, cutting-edge science in the areas of astrophysics, space physics, solid planetary geoscience, and...

  20. Respiratory Protection Program

    Broader source: Energy.gov [DOE]

    This page is supported by the Respiratory Protection Program Administrators Group. The Respiratory Protection Program Administrators Group is a volunteer organization co-sponsored by the DOE Office of Worker Safety and Health Policy and the Energy Facility Contractors Group (EFCOG) to provide a forum for DOE and DOE contractor personnel to identify respiratory protection issues of concern to the DOE and pursue solutions to issues identified.

  1. Protective Actions and Reentry

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1997-08-21

    This volume defines appropriate protective actions and reentry of a site following an emergency. Canceled by DOE G 151.1-4.

  2. Physical Protection Program Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-12-23

    Supplements DOE O 473.1, by establishing requirements for the physical protection of safeguards and security interests. Cancels: DOE M 5632.1C-1

  3. Asset Protection Analysis Guide

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-21

    The Guide provides examples of the application of as set protection analysis to several common problems. Canceled by DOE N 251.80.

  4. Environmental Protection: Controlling the Present

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection community-environmentassetsimagesiconearthday.jpg Environmental Protection: Controlling the Present The Laboratory is committed to increasing sustainable practices...

  5. Environmental protection Implementation Plan

    SciTech Connect (OSTI)

    R. C. Holland

    1999-12-01

    This ``Environmental Protection Implementation Plan'' is intended to ensure that the environmental program objectives of Department of Energy Order 5400.1 are achieved at SNL/California. This document states SNL/California's commitment to conduct its operations in an environmentally safe and responsible manner. The ``Environmental Protection Implementation Plan'' helps management and staff comply with applicable environmental responsibilities.

  6. Protective Force Program Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-12-20

    Provides detailed requirements to supplement DOE O 473.2, PROTECTIVE FORCE PROGRAM, which establishes the requirements and responsibilities for management and operation of the Department of Energy (DOE) Protective Force (PF) Program. Change 1 revised pages in Chapters IV and VI on 12/20/2001.

  7. Environmental Protection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-01-15

    To implement sound stewardship practices that are protective of the air, water, land, and other natural and cultural resources impacted by the Department of Energy (DOE) operations and by which DOE cost effectively meets or exceeds compliance with applicable environmental; public health; and resource protection laws, regulations, and DOE requirements. Cancels DOE 5400.1 and DOE N 450.4.

  8. Protection Program Operations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-03-23

    The Order establishes requirements for the management and operation of the DOE Federal Protective Forces (FPF), Contractor Protective Forces (CPF), and the Physical Security of property and personnel under the cognizance of DOE. Supersedes DOE O 473.3. NOTE: Safeguards and Security Alarm Management and Control Systems, of DOE O 473.3, is retained as Attachment 3, Annex 1.

  9. EVM Subject Matter Experts | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management » EVM Subject Matter Experts EVM Subject Matter Experts Name Title Office * Phone Email Melvin Frank Chief, Project Management Policy and Systems PM-30 202-586-5519 Send Email David Kester EVMS Subject Matter Expert PM-30 202-586-4342 Send Email Robert Loop EVMS Subject Matter Expert PM-30 202-287-1324 Send Email Karen Urschel (CONTR) EVMS Subject Matter Expert PM-30 260-417-2184 Send Email Buck Wilkerson (CONTR) Planning and Scheduling Subject Matter Expert PM-30 678-360-3161 Send

  10. U.S. Environmental Protection Agency | Department of Energy

    Energy Savers [EERE]

    Agency (EPA) is to protect human health and the environment. EPA achieves this by keeping pollution out of the air we breathe, the water we drink and swim in, and harmful chemicals...

  11. Fire protection design criteria

    SciTech Connect (OSTI)

    1997-03-01

    This Standard provides supplemental fire protection guidance applicable to the design and construction of DOE facilities and site features (such as water distribution systems) that are also provided for fire protection. It is intended to be used in conjunction with the applicable building code, national Fire Protection Association Codes and Standards, and any other applicable DOE construction criteria. This Standard, along with other delineated criteria, constitutes the basic criteria for satisfying DOE fire and life safety objectives for the design and construction or renovation of DOE facilities.

  12. CALUTRON PROTECTIVE CIRCUIT

    DOE Patents [OSTI]

    Schmidt, F.H.

    1959-05-26

    A switch and relay circuit is described for protection of calutrons. By means of this arrangement no arc can be established in the arc chamber unless cooling water flow is established. (T.R.H.)

  13. Physical Protection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-12-23

    Establishes Department of Energy management objectives, requirements and responsibilities for the physical protection of safeguards and security interests. Cancels DOE 5632.1C. Canceled by DOE O 470.4.

  14. Protective Force Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-02-13

    To prescribe Department of Energy policy, responsibilities, and requirements for the management and operation of the Protective Force Program. Chg 1 dated 2-13-95. Cancels DOE O 5632.7 and DOE O 5632.8.

  15. Federal Protective Force

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-07-15

    This Manual establishes requirements for the management and operation of the Department of Energy (DOE) Federal protective forces (FPFs). Cancels DOE M 470.4-3, Chg 1. Canceled by DOE O 473.3.

  16. Environmental Protection, Safety, and Health Protection Program for DOE Operations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1980-05-05

    This order establishes the Environmental Protection, Safety, and Health Protection Program for Department of Energy (DOE) operations. Cancels Interim Management Directive No. 5001, Safety, Health And Environmental Protection dated 9-29-77.

  17. Environmental Protection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-01-15

    To implement sound stewardship practices that are protective of the air, water, land, and other natural and cultural resources impacted by the Department of Energy (DOE) operations and by which DOE cost effectively meets or exceeds compliance with applicable environmental; public health; and resource protection laws, regulations, and DOE requirements. Chg 1, dated 1-24-05; Chg 2, dated 12-7-05; Admin Chg 1, dated 1-3-07. Cancels DOE 5400.1 and DOE N 450.4.

  18. Protecting Against Nuclear Threats

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Against Nuclear Threats Protecting Against Nuclear Threats Los Alamos' mission is to solve national security challenges through scientific excellence. April 12, 2012 Los Alamos researchers use a magnetic field detector to screen carry-on liquids at airports Los Alamos researchers use a magnetic field detector to screen carry-on liquids at airports: MagViz project leader Michelle Espy demonstrates the MagViz liquid detection and analysis system in the Albuquerque International Sunport.

  19. Environmental Protection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-06-04

    The objective is to implement sound stewardship practices that are protective of the air, water, land, and other natural and cultural resources impacted by DOE operations, and meet or exceed compliance with applicable environmental, public health, and resource protection requirements cost effectively. The revision provides specific expectations for implementation of Executive Order 13423, Strengthening Federal Environment, Energy, and Transportation Management. Cancels DOE O 450.1. Canceled by DOE O 436.1.

  20. Voluntary Protection Program- Basics

    Broader source: Energy.gov [DOE]

    The Department of Energy Voluntary Protection Program (DOE-VPP) promotes safety and health excellence through cooperative efforts among labor, management, and government at the Department of Energy (DOE) contractor sites. DOE has also formed partnerships with other Federal agencies and the private sector for both advancing and sharing its Voluntary Protection Program (VPP) experiences and preparing for program challenges in the next century. The safety and health of contractor and federal employees are a high priority for the Department.

  1. Protecting your personal information

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting your personal information Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: September 1, 2016 all issues All Issues » submit Protecting your personal information Quantum cryptography keeps data secure from cyber thieves October 1, 2014 Mass-producible quantum smart card and fiber optics cable. Mass-producible quantum smart card and fiber optics cable. Contact Community Programs Director Kurt Steinhaus Email Editor Ute Haker

  2. General Environmental Protection Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1990-06-29

    To establish environmental protection program requirements, authorities, and responsibilities for Department of Energy (DOE) Operations for assuring compliance with applicable Federal, State and local environmental protection laws and regulations, Executive Orders, and internal Department policies. Cancels DOE O 5480.1A. Para. 2b, 4b, and 4c of Chap. II and para. 2d and 3b of Chap. III canceled by DOE O 231.1.

  3. Advanced worker protection system

    SciTech Connect (OSTI)

    Caldwell, B.; Duncan, P.; Myers, J.

    1995-10-01

    The Department of Energy (DOE) is in the process of defining the magnitude and diversity of Decontamination and Decommissioning (D&D) obligations at its numerous sites. The DOE believes that existing technologies are inadequate to solve many challenging problems such as how to decontaminate structures and equipment cost effectively, what to do with materials and wastes generated, and how to adequately protect workers and the environment. Preliminary estimates show a tremendous need for effective use of resources over a relatively long period (over 30 years). Several technologies are being investigated which can potentially reduce D&D costs while providing appropriate protection to DOE workers. The DOE recognizes that traditional methods used by the EPA in hazardous waste site clean up activities are insufficient to provide the needed protection and worker productivity demanded by DOE D&D programs. As a consequence, new clothing and equipment which can adequately protect workers while providing increases in worker productivity are being sought for implementation at DOE sites. This project describes the development of an Advanced Worker Protection System (AWPS) which will include a life-support backpack with liquid air for cooling and as a supply of breathing gas, protective clothing, respirators, communications, and support equipment.

  4. Executive Order-Strengthening Protections Against Trafficking in Persons in Federal Contracts

    Broader source: Energy.gov [DOE]

    On September 25, 2012, President Obama issued an Executive Order (EO) that seeks to strengthen protections against human trafficking in federal contracting. Currently, the Federal Acquisition...

  5. Metallothionein protection of cadmium toxicity

    SciTech Connect (OSTI)

    Klaassen, Curtis D. Liu, Jie; Diwan, Bhalchandra A.

    2009-08-01

    The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein called metallothionein (MT) in Cd toxicology. MT plays minimal roles in the gastrointestinal absorption of Cd, but MT plays important roles in Cd retention in tissues and dramatically decreases biliary excretion of Cd. Cd-bound to MT is responsible for Cd accumulation in tissues and the long biological half-life of Cd in the body. Induction of MT protects against acute Cd-induced lethality, as well as acute toxicity to the liver and lung. Intracellular MT also plays important roles in ameliorating Cd toxicity following prolonged exposures, particularly chronic Cd-induced nephrotoxicity, osteotoxicity, and toxicity to the lung, liver, and immune system. There is an association between human and rodent Cd exposure and prostate cancers, especially in the portions where MT is poorly expressed. MT expression in Cd-induced tumors varies depending on the type and the stage of tumor development. For instance, high levels of MT are detected in Cd-induced sarcomas at the injection site, whereas the sarcoma metastases are devoid of MT. The use of MT-transgenic and MT-null mice has greatly helped define the role of MT in Cd toxicology, with the MT-null mice being hypersensitive and MT-transgenic mice resistant to Cd toxicity. Thus, MT is critical for protecting human health from Cd toxicity. There are large individual variations in MT expression, which might in turn predispose some people to Cd toxicity.

  6. Protection of the Groundwater Resource

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection of the Groundwater Resource Protection of the Groundwater Resource Monitoring wells act as sentinels between suspected LANL contamination and the water supply. August 1,...

  7. Protections: Sediment Control = Contaminant Retention

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment Control Protections: Sediment Control Contaminant Retention LANL maintains hundreds of wells, stream sampling stations and stormwater control structures to protect...

  8. Rack protection monitor

    DOE Patents [OSTI]

    Orr, Stanley G.

    2000-01-01

    A hardwired, fail-safe rack protection monitor utilizes electromechanical relays to respond to the detection by condition sensors of abnormal or alarm conditions (such as smoke, temperature, wind or water) that might adversely affect or damage equipment being protected. When the monitor is reset, the monitor is in a detection mode with first and second alarm relay coils energized. If one of the condition sensors detects an abnormal condition, the first alarm relay coil will be de-energized, but the second alarm relay coil will remain energized. This results in both a visual and an audible alarm being activated. If a second alarm condition is detected by another one of the condition sensors while the first condition sensor is still detecting the first alarm condition, both the first alarm relay coil and the second alarm relay coil will be de-energized. With both the first and second alarm relay coils de-energized, both a visual and an audible alarm will be activated. In addition, power to the protected equipment will be terminated and an alarm signal will be transmitted to an alarm central control. The monitor can be housed in a separate enclosure so as to provide an interface between a power supply for the protected equipment and the protected equipment.

  9. Rack Protection Monitor

    SciTech Connect (OSTI)

    Orr, Stanley G.

    1998-10-21

    A hardwired, fail-safe rack protection monitor utilizes electromechanical relays to respond to the detection by condition sensors of abnormal or alarm conditions (such as smoke, temperature, wind or water) that might adversely affect or damage equipment being protected. When the monitor is reset, the monitor is in a detection mode with first and second alarm relay coils energized. If one of the condition sensors detects an abnormal condition, the first alarm relay coil will be de-energized, but the second alarm relay coil will remain energized. This results in both a visual and an audible alarm being activated. If a second alarm condition is detected by another one of the condition sensors while the first condition sensor is still detecting the first alarm condition, both the first alarm relay coil and the second alarm relay coil will be de-energized. With both the first and second alarm relay coils de-energized, both a visual and an audible alarm will be activated. In addition, power to the protected equipment will be terminated and an alarm signal will be transmitted to an alarm central control. The monitor can be housed in a separate enclosure so as to provide an interface between a power supply for the protected equipment and the protected equipment.

  10. Genome Wide Evaluation of Normal Human Tissue in Response to...

    Office of Scientific and Technical Information (OSTI)

    Subject: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 61 RADIATION PROTECTION AND DOSIMETRY Low-dose radiation; gene expression Word ...

  11. Microscope collision protection apparatus

    DOE Patents [OSTI]

    DeNure, Charles R.

    2001-10-23

    A microscope collision protection apparatus for a remote control microscope which protects the optical and associated components from damage in the event of an uncontrolled collision with a specimen, regardless of the specimen size or shape. In a preferred embodiment, the apparatus includes a counterbalanced slide for mounting the microscope's optical components. This slide replaces the rigid mounts on conventional upright microscopes with a precision ball bearing slide. As the specimen contacts an optical component, the contacting force will move the slide and the optical components mounted thereon. This movement will protect the optical and associated components from damage as the movement causes a limit switch to be actuated, thereby stopping all motors responsible for the collision.

  12. Environmental protection implementation plan

    SciTech Connect (OSTI)

    Holland, R.C.

    1998-03-01

    This Environmental Protection Implementation Plan is intended to ensure that the environmental program objectives of Department of Energy Order 5400.1 are achieved at SNL/California. This document states SNL/California`s commitment to conduct its operations in an environmentally safe and responsible manner. The Environmental Protection Implementation Plan helps management and staff comply with applicable environmental responsibilities. SNL is committed to operating in full compliance with the letter and spirit of applicable environmental laws, regulations, and standards. Furthermore, SNL/California strives to go beyond compliance with legal requirements by making every effort practical to reduce impacts to the environment to levels as low as reasonably achievable.

  13. Material for radioactive protection

    DOE Patents [OSTI]

    Taylor, R.S.; Boyer, N.W.

    A boron containing burn resistant, low-level radiation protection material useful, for example, as a liner for radioactive waste disposal and storage, a component for neutron absorber, and a shield for a neutron source is described. The material is basically composed of borax in the range of 25 to 50%, coal tar in the range of 25 to 37.5%, with the remainder being an epoxy resin mix. A preferred composition is 50% borax, 25% coal tar and 25% epoxy resin. The material is not susceptible to burning and is about 1/5 the cost of existing radiation protection material utilized in similar applications.

  14. Office of River Protection - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of River Protection Office of River Protection Office of River Protection Office of River Protection Email Email Page | Print Print Page |Text Increase Font Size Decrease...

  15. SciTech Connect: Explore by Subject

    Office of Scientific and Technical Information (OSTI)

    Explore by Subject Explore by Subject All Topics Biology and Medicine Chemistry Energy Storage, Conversion, and Utilization Engineering Environmental Sciences Fission and Nuclear Technologies Fossil Fuels Geosciences Materials Mathematics and Computing National Defense Physics Power Generation and Distribution Renewable Energy Sources ... Matching Records: Result Type: Everything Full Text Citations Multimedia Datasets Document Type: All Document Types Book/Monograph Conference/Event Dataset

  16. Thermal protection apparatus

    DOE Patents [OSTI]

    Bennett, G.A.; Elder, M.G.; Kemme, J.E.

    1984-03-20

    The disclosure is directed to an apparatus for thermally protecting sensitive components in tools used in a geothermal borehole. The apparatus comprises a Dewar within a housing. The Dewar contains heat pipes such as brass heat pipes for thermally conducting heat from heat sensitive components such as electronics to a heat sink such as ice.

  17. Fire Protection Training

    Office of Energy Efficiency and Renewable Energy (EERE)

    Fire Protection Training courses developed that provide needed information and a method to train fire departments and other emergency responders who may be called upon to respond to accidents involving radioactive materials along DOE transportation corridors and routes and to assist emergency responders located at or near a Department of Energy (DOE) site radiological transportation route.

  18. Thermal protection apparatus

    DOE Patents [OSTI]

    Bennett, Gloria A.; Elder, Michael G.; Kemme, Joseph E.

    1985-01-01

    An apparatus which thermally protects sensitive components in tools used in a geothermal borehole. The apparatus comprises a Dewar within a housing. The Dewar contains heat pipes such as brass heat pipes for thermally conducting heat from heat sensitive components to a heat sink such as ice.

  19. Protective Force Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-06-30

    Establishes policy, requirements, responsibilities, and authorities, for the management and operation of the Department of Energy (DOE) Protective Force (PF) Program. Extended until 7-7-06 by DOE N 251.64, dated 7-7-05 Cancels: DOE 5632.7A

  20. Contractor Protective Force

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-11-05

    This Manual establishes requirements for the management and operation of the U.S. Department of Energy contractor protective forces. Cancels: DOE M 470.4-3 Chg 1, CRD (Attachment 2) only, except for Section C. Canceled by DOE O 473.3.

  1. Armored garment for protecting

    DOE Patents [OSTI]

    Purvis, James W.; Jones, II, Jack F.; Whinery, Larry D.; Brazfield, Richard; Lawrie, Catherine; Lawrie, David; Preece, Dale S.

    2009-08-11

    A lightweight, armored protective garment for protecting an arm or leg from blast superheated gases, blast overpressure shock, shrapnel, and spall from a explosive device, such as a Rocket Propelled Grenade (RPG) or a roadside Improvised Explosive Device (IED). The garment has a ballistic sleeve made of a ballistic fabric, such as an aramid fiber (e.g., KEVLAR.RTM.) cloth, that prevents thermal burns from the blast superheated gases, while providing some protection from fragments. Additionally, the garment has two or more rigid armor inserts that cover the upper and lower arm and protect against high-velocity projectiles, shrapnel and spall. The rigid inserts can be made of multiple plies of a carbon/epoxy composite laminate. The combination of 6 layers of KEVLAR.RTM. fabric and 28 plies of carbon/epoxy laminate inserts (with the inserts being sandwiched in-between the KEVLAR.RTM. layers), can meet the level IIIA fragmentation minimum V.sub.50 requirements for the US Interceptor Outer Tactical Vest.

  2. MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM:

    Broader source: Energy.gov (indexed) [DOE]

    April 27,2010 MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM: s r x j ) bi Le OFFICE HE CHIEF HUMAN CAPITAL OFFICER SUBJECT: GUIDANCE MEMORANDUM 8: DOE FAIR LABOR STANDARDS ACT ...

  3. Research Subject Areas for CSES Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Subject Areas Research Subject Areas for CSES Proposals High quality, cutting-edge science in the areas of astrophysics, space physics, solid planetary geoscience, and climate science. Contact Director Reiner Friedel (505) 665-1936 Email Professional Staff Assistant Georgia D. Sanchez (505) 665-0855 Email Science Discipline Leaders Astrophysics & Cosmology Hui Li (505) 665-3131 Email Climate Keeley Costigan (505) 665-4788 Email Geophysics David Coblentz (505) 667-2781 Email Space

  4. PREPUBLICATION COPY - SUBJECT TO FURTHER EDITORIAL CHANGE

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and business and financial services. The 2014 pilot of the Enterprise Risk Management (ERM) Model for human resources requirements suggests that DOE is making efforts to move...

  5. Environmental Protection, Safety, and Health Protection Program for DOE Operations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1981-08-13

    This Order establishes the Environmental Protection, Safety. and Health Protection Program for Department of Energy (DOE) operations. Cancels DOE 5480.1, dated 5-5-1980, its chapters are not canceled. Canceled by DOE O 5480.1B

  6. Cathodic protection of a remote river pipeline

    SciTech Connect (OSTI)

    Martin, B.A. )

    1994-03-01

    The 261-km long 500-mm diam Kutubu pipeline, which runs through dense jungle swamps in Papua, New Guinea, was built for Chevron Niugini to transport oil from the remote Kutubu oil production facility in the Southern Highlands to an offshore loading facility. The pipeline was laid with a section in the bed of a wide, fast-flowing river. This section was subject to substantial telluric effects and current density variations from changing water resistivities. The cathodic protection system's effectiveness was monitored by coupon off'' potentials and required an innovative approach.

  7. Protecting FWP Participant Personally Identifiable Information/Protected

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Health Information | Department of Energy Protecting FWP Participant Personally Identifiable Information/Protected Health Information Protecting FWP Participant Personally Identifiable Information/Protected Health Information The confidentiality and privacy rights of former workers are not only a legal requirement, they are crucial to establishing and maintaining credibility with the former worker community. All medical information that is collected as part of this program is treated as

  8. Fire Protection Account Request Form

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fire Protection System Account Request Form To obtain a user id and password to access the Fire Protection system, please complete the form, save the file and email it to...

  9. Protection of the Groundwater Resource

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection of the Groundwater Resource Protection of the Groundwater Resource Monitoring wells act as sentinels between suspected LANL contamination and the water supply. August 1, 2013 Where to place a sentinel well Where

  10. "Protecting Public Health through Biosecurity"

    SciTech Connect (OSTI)

    Seiders, Barbara AB; Campbell, James R.

    2006-03-04

    "Protecting Public Health through Biosecurity" is an article writen for the Tri-City Herald newspaper special Progress Edition.

  11. Los Alamos Lab: Radiation Protection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CONTACTS Division Leader Shawna Eisele Office Administrator Shirley D. Martinez Senior Advisor Paul Hoover Special Assistant and Issues Management Coordinator Elinor Gwynn Radiation Protection Radiation Protection The Radiation Protection Division supports the Laboratory in accomplishing its mission by helping to ensure radiological work is conducted safely and within requirements established by Occupational Radiation Protection (10 CFR 835) and enforced under the Price Anderson Amendments Act.

  12. RHIC prefire protection masks

    SciTech Connect (OSTI)

    Drees, A.; Biscardi, C.; Curcio, T.; Gassner, D.; DeSanto, L.; Fu, W.; Liaw, C. J.; Montag, C.; Thieberger, P.; Yip, K.

    2015-01-07

    The protection of the RHIC experimental detectors from damage due to beam hitting close upstream elements in cases of abort kicker prefires requires some dedicated precautionary measures with two general options: to bring the beam close to a limiting aperture (i.e. the beam pipe wall), as far upstream of the detector components as possible or, alternatively, to bring a limiting aperture close to the circulating beam. Spontaneous and random prefires of abort kicker modules (Pulse Forming Network, PFN) have a history as long as RHIC is being operated. The abort system consist of 5 kickers in per ring, each of them equipped with its own dedicated PFN.

  13. Designing radiation protection signs

    SciTech Connect (OSTI)

    Rodriguez, M.A.; Richey, C.L.

    1995-03-01

    Entry into hazardous areas without the proper protective equipment is extremely dangerous and must be prevented whenever possible. Current postings of radiological hazards at the Rocky Flats Environmental Technology Site (RFETS) do not incorporate recent findings concerning effective warning presentation. Warning information should be highly visible, quickly, and easily understood. While continuing to comply with industry standards (e.g., Department of Energy (DOE) guidelines), these findings can be incorporated into existing radiological sign design, making them more effective in terms of usability and compliance. Suggestions are provided for designing more effective postings within stated guidelines.

  14. Hearing protection for miners

    SciTech Connect (OSTI)

    Schulz, T.

    2008-10-15

    A NIOSH analysis showed that at age 50 approximately 90% of coal miners have a hearing impairment, yet noise included hearing loss is 100% preventable. The article discusses requirements of the MSHA regulations, 30 CFR Part 62 - occupational noise exposure (2000) and a 2008-MSHA document describing technologically achievable and promising controls for several types of mining machinery. Hearing protection is still required for exposure to greater than 90 dBA. These are now commercially available ways to determine how much attenuation an individual gets from a given hearing protector, known as 'fit testing'. 3 refs., 1 fig., 1 tab., 1 photo.

  15. Notices ENVIRONMENTAL PROTECTION AGENCY

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    41 Federal Register / Vol. 80, No. 243 / Friday, December 18, 2015 / Notices ENVIRONMENTAL PROTECTION AGENCY [ER-FRL-9024-5] Environmental Impact Statements; Notice of Availability Responsible Agency: Office of Federal Activities, General Information (202) 564-7146 or http://www2.epa.gov/nepa. Weekly receipt of Environmental Impact Statements Filed 12/07/2015 Through 12/11/2015 Pursuant to 40 CFR 1506.9. Notice Section 309(a) of the Clean Air Act requires that EPA make public its comments on

  16. Environmental Protection Agency

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ulllicu 3idica Environmental Protection Agency riivirrjlriiiciliar rVruillivitlr~ Systems Laboratory P.O. Box 93478 Las Vegas NV 89193-3478 ctr\/ O",, +-05, " 63 -EOE/DP/00539-061 May 1989 Research and Development . GEPA Off-Site Environmental Monitoring Report Radiation Monitoring Around United. States Nuclear Test Areas, Calendar Year 1988 EPA-600/4-891019 DOE/DP/00539-061 May 1989 Off-Site Environmental Monitoring Report Radiation Monitoring Around United'States Nuclear Test Areas,

  17. Molecular Mimicry of SUMO by Rad60 Helps Protect the Genome from...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Mimicry of SUMO by Rad60 Helps Protect the Genome from Toxic Stress DNA is subject to multiple forms of damage that can occur either spontaneously, through sources such...

  18. For Researchers | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researchers Human Subjects Protection Program (HSPP) HSPP Home About For Researchers ... Institutional Officials For Prospective Human Subjects Leads Annual Reports ...

  19. Model assessment of protective barrier designs

    SciTech Connect (OSTI)

    Fayer, M.J.; Conbere, W.; Heller, P.R.; Gee, G.W.

    1985-11-01

    A protective barrier is being considered for use at the Hanford site to enhance the isolation of previously disposed radioactive wastes from infiltrating water, and plant and animal intrusion. This study is part of a research and development effort to design barriers and evaluate their performance in preventing drainage. A fine-textured soil (the Composite) was located on the Hanford site in sufficient quantity for use as the top layer of the protective barrier. A number of simulations were performed by Pacific Northwest Laboratory to analyze different designs of the barrier using the Composite soil as well as the finer-textured Ritzville silt loam and a slightly coarser soil (Coarse). Design variations included two rainfall rates (16.0 and 30.1 cm/y), the presence of plants, gravel mixed into the surface of the topsoil, an impermeable boundary under the topsoil, and moving the waste form from 10 to 20 m from the barrier edge. The final decision to use barriers for enhanced isolation of previously disposed wastes will be subject to decisions resulting from the completion of the Hanford Defense Waste Environmental Impact Statement, which addresses disposal of Hanford defense high-level and transuranic wastes. The one-dimensional simulation results indicate that each of the three soils, when used as the top layer of the protective barrier, can prevent drainage provided plants are present. Gravel amendments to the upper 30 cm of soil (without plants) reduced evaporation and allowed more water to drain.

  20. Economical wind protection - underground

    SciTech Connect (OSTI)

    Kiesling, E.W.

    1980-01-01

    Earth-sheltered buildings inherently posess near-absolute occupant protection from severe winds. They should sustain no structural damage and only minimal facial damage. Assuming that the lower-hazard risk attendant to this type of construction results in reduced insurance-premium rates, the owner accrues economic benefits from the time of construction. Improvements to aboveground buildings, in contrast, may not yield early economic benefits in spite of a favorable benefit-to-cost ratio. This, in addition to sensitivity to initial costs, traditionalism in residential construction, and lack of professional input to design, impede the widespread use of underground improvements and the subsequent economic losses from severe winds. Going underground could reverse the trend. 7 references.

  1. Thermal protection apparatus

    DOE Patents [OSTI]

    Bennett, Gloria A.; Moore, Troy K.

    1988-01-01

    An apparatus for thermally protecting heat sensitive components of tools. The apparatus comprises a Dewar for holding the heat sensitive components. The Dewar has spaced-apart inside and outside walls, an open top end and a bottom end. An insulating plug is located in the top end. The inside wall has portions defining an inside wall aperture located at the bottom of the Dewar and the outside wall has portions defining an outside wall aperture located at the bottom of the Dewar. A bottom connector has inside and outside components. The inside component sealably engages the inside wall aperture and the outside component sealably engages the outside wall aperture. The inside component is operatively connected to the heat sensitive components and to the outside component. The connections can be made with optical fibers or with electrically conducting wires.

  2. ELECTRICAL PROTECTIVE DEVICE

    DOE Patents [OSTI]

    Baker, W.R.

    1958-05-01

    A protective system for high-energy resonant cavities is described. It is particularly directed to the discharging of resonant cavities for preventing energy back flow through associated equipment as a result of faults. The invention in general provides means defining a spark gap communicating with the interior of a cavity or waveguide adapted for high-power energization or an evacuated chamber containing an electrode having a large power differential from the wall or other electrode. A control or trigger circuit is connected between a power supply energizing the cavity and the spark gap whereby reverse current flow in the power supply circuit instantaneously triggers the spark gap to initiate discharge within the cavity, whereupon cavity energy discharges across the gap, or with an electrode present the electrode discharges to one of the spark gap elements.

  3. Protection Program Operations - DOE Directives, Delegations,...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3.3, Protection Program Operations by jcronin Functional areas: Physical Protection, Protective Force, Safeguards, Security, and Emergency Management The Order establishes...

  4. Office of River Protection - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of River Protection Office of River Protection About ORP ORP Projects & Facilities Newsroom Contracts & Procurements Contact ORP Office of River Protection Email Email Page...

  5. Voluntary Protection Program Onsite Review, Washington River...

    Energy Savers [EERE]

    Washington River Protection Solutions, LLC, Hanford - Feb 2014 Voluntary Protection Program Onsite Review, Washington River Protection Solutions, LLC, Hanford - Feb 2014 February...

  6. (Basic radiation protection criteria). Final report

    SciTech Connect (OSTI)

    Ney, W.R.

    1982-12-03

    Progress in the following areas directly related to nuclear waste management is summarized: (1) a radiation protection system based on risk per rad of dose; (2) assessment of the accumulation and biological significance of industrial waste discharges and estimation of concentrations present in the environment; (3) assessment of exposure resulting from nuclear power; (4) internal emitter standards; (5) human radiation exposure experience; (6) the identification of national needs related to the estimation of exposure of the public from ionizing radiation; and (7) acceptable risk for management of radioactive waste. (ACR)

  7. Protections: Sediment Control = Contaminant Retention

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sediment Control Protections: Sediment Control = Contaminant Retention LANL maintains hundreds of wells, stream sampling stations and stormwater control structures to protect waters. August 1, 2013 Los Alamos Canyon weir Los Alamos Canyon weir thumbnail of Protection #2: Trap and Remove Sediment Sediment behind LA Canyon weir is sampled and excavated regularly. As of 2012, no sediment required disposal as hazardous or radioactive waste. RELATED IMAGES

  8. Protective link for superconducting coil

    DOE Patents [OSTI]

    Umans, Stephen D.

    2009-12-08

    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  9. Environmental Protection: Controlling the Present

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection Environmental Protection: Controlling the Present The Laboratory is committed to increasing sustainable practices and complying with environmental regulations. What We Monitor & Why» Cultural Preservation» Taking Care of our Trails» Obeying Environmental Laws» Protecting Wildlife» Feature Stories» TOP STORIES - highlights of our science, people, technologies close Los Alamos National Laboratory begins pumping tests on chromium plume The chromium originated from cooling

  10. MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\\O~TOR OFFICE...

    Broader source: Energy.gov (indexed) [DOE]

    0 MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: SJOTOR OFFICE b:HUMAN CAPITAL MANAGEMENT SUBJECT: GUIDANCE MEMORANDUM 13 REEMPLOYMENT PRIORITY LIST SELECTIONS This memorandum ...

  11. CEBAF - environmental protection program plan

    SciTech Connect (OSTI)

    1995-10-01

    An important objective in the successful operation of the Continuous Electron Beam Accelerator Facility (CEBAF) is to ensure protection of the public and the environment. To meet this objective, the Southeastern Universities Research Association, Inc., (SURA) is committed to working with the US Department of Energy (DOE) to develop, implement, and manage a sound and workable environmental protection program at CEBAF. This environmental protection plan includes information on environmental monitoring, long-range monitoring, groundwater protection, waste minimization, and pollution prevention awareness program plan.

  12. What waters does LANL protect?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    What waters does LANL protect? What waters does LANL protect? Rainfall in the Jemez Mountains flows to the Valles Caldera and eastward onto Laboratory lands. August 1, 2013 Reflection in the Valles Caldera RELATED IMAGES http://farm8.staticflickr.com/7252/7599998130_b7aef738b9_t.jpg Enlarge http://farm9.staticflickr.com/8421/7600000986_ebf8889fc7_t.jpg Enlarge Clean the Past: Water Protection What waters does LANL protect? Google Earth Tour: Waters around LANL Jemez Mountains Headwaters

  13. What waters does LANL protect?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    does LANL protect? Google Earth Tour: Waters around LANL Jemez Mountains Headwaters Watersheds The Rio Grande Buckman Direct Diversion Project Groundwater in the Regional Aquifer...

  14. EO 13158: Marine Protected Areas

    Broader source: Energy.gov [DOE]

    This Executive Order will help protect the significant natural and cultural resources within the marine environment for the benefit of present and future generations by strengthening and expanding...

  15. Protections: Sediment Control = Contaminant Retention

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LANL maintains hundreds of wells, stream sampling stations and stormwater control ... Protection 2: Trap and Remove Sediment Stormwater Controls The Individual Permit for ...

  16. Classified Matter Protection and Control

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-26

    Provides detailed requirements to supplement DOE O 471.2, which establishes policy for the protection and control of classified and unclassified information. Does not cancel other directives.

  17. EPA's groundwater protection strategy

    SciTech Connect (OSTI)

    Smith, J. )

    1992-06-01

    What the EPA, working jointly with the states, hopes to accomplish over the next ten years in order to integrate and coordinate all the groundwater programs within the agency is discussed. Although many other EPA programs such as Superfund, Clean Air Act, and Wetlands Management are often highlighted in the media, EPA does not down rate the importance of groundwater protection. Indeed as a resource, it is one of the most important commodities. Groundwater is the basis for life in this country. Recharge rates are no where near what the withdrawal rates are in many areas of the country. Twenty-five percent of all the potable water comes from groundwater. Groundwater supplies 50 percent of the needs for all the US population. If you include strictly rural areas, it supplies 95 percent of all the use. Something that most people who are not groundwater hydrologists would not think about is the fact that groundwater is a recharge mechanism that provides over 30 percent of the flow in streams and major rivers.

  18. Beijing Hualianda Environmental Protection Energy Technology...

    Open Energy Info (EERE)

    Hualianda Environmental Protection Energy Technology Development Co Ltd Jump to: navigation, search Name: Beijing Hualianda Environmental Protection Energy Technology Development...

  19. Shanxi Taiyuan Zihuan Environmental Protection Technology | Open...

    Open Energy Info (EERE)

    Taiyuan Zihuan Environmental Protection Technology Jump to: navigation, search Name: Shanxi Taiyuan Zihuan Environmental Protection Technology Place: Taiyuan City, Shaanxi...

  20. Material Protection, Control, & Accounting | National Nuclear...

    National Nuclear Security Administration (NNSA)

    Nonproliferation Nuclear and Radiological Material Security Material Protection, Control, & Accounting Material Protection, Control, & Accounting NNSA implements material...

  1. Voluntary Protection programs Participants' Association - Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Protection Programs Participants' Association (VPPPA) Presentations: Star Track Voluntary Protection Programs Participants' Association (VPPPA) Presentation: Wellness Programs

  2. To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    From: ecchimento@comcast.net [mailto:ecchimento@comcast.net] Sent: Monday, January 29, 2007 6:28 PM To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Larry, Regarding the planned line outage, scheduled for Feb. 20 through Mar. 6, I am requesting that the residents near the plant be moved for the duration of the outage to protect their health. Would you include this comment also in the ongoing recorded discussion? Thank you. Elizabeth -----Original Message-----

  3. Combined group ECC protection and subgroup parity protection

    DOE Patents [OSTI]

    Gara, Alan G.; Chen, Dong; Heidelberger, Philip; Ohmacht, Martin

    2013-06-18

    A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit wide vectors with three or more, but an odd number of, elements with value one and the other elements with value zero; and assigning said vectors to rows of the matrix P.

  4. Combined group ECC protection and subgroup parity protection

    DOE Patents [OSTI]

    Gara, Alan; Cheng, Dong; Heidelberger, Philip; Ohmacht, Martin

    2016-02-02

    A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit wide vectors with three or more, but an odd number of, elements with value one and the other elements with value zero; and assigning said vectors to rows of the matrix P.

  5. Human Resources | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources

  6. Creating LTS&M Efficiencies While Protecting Human Health and...

    Energy Savers [EERE]

    costs and material use. The documented cost savings from these efforts exceeds ... In 2011, wells were installed to supplant annual drilling of temporary wells at two ...

  7. Jr., Process Development Branch Construction Division SUBJECT:

    Office of Legacy Management (LM)

    FR?M : Jr., Process Development Branch Construction Division SUBJECT: INING TESTS AT BOWEN ENGINEERING, INC. - M A Y 16 AND 16,!1961 SYMBOL! EPD:ABBrbt I REY~AKC~: &DiVE;G?i&)il [q a 1 $ a, " I On day 16 and 16,,1951 Bowen Engineering, Inc. made test rune on ypray calcining of boiled-down Mallinokrodt pitohblende raffinate. Theqe rune were made in Bowen'e laboratory unit et North Branch, NT Jel;sey. The initial results indicate that raffidate &$be euocessfully epray oalcined to

  8. Corrosion protection for silver reflectors

    DOE Patents [OSTI]

    Arendt, Paul N.; Scott, Marion L.

    1991-12-31

    A method of protecting silver reflectors from damage caused by contact with gaseous substances which are often present in the atmosphere and a silver reflector which is so protected. The inventive method comprises at least partially coating a reflector with a metal oxide such as aluminum oxide to a thickness of 15 .ANG. or less.

  9. Adaptive protection algorithm and system

    DOE Patents [OSTI]

    Hedrick, Paul (Pittsburgh, PA) [Pittsburgh, PA; Toms, Helen L. (Irwin, PA) [Irwin, PA; Miller, Roger M. (Mars, PA) [Mars, PA

    2009-04-28

    An adaptive protection algorithm and system for protecting electrical distribution systems traces the flow of power through a distribution system, assigns a value (or rank) to each circuit breaker in the system and then determines the appropriate trip set points based on the assigned rank.

  10. International Energy: Subject Thesaurus. Revision 1

    SciTech Connect (OSTI)

    Not Available

    1993-11-01

    The International Energy Agency: Subject Thesaurus contains the standard vocabulary of indexing terms (descriptors) developed and structured to build and maintain energy information databases. Involved in this cooperative task are (1) the technical staff of the USDOE Office of Scientific and Technical Information (OSTI) in cooperation with the member countries of the International Energy Agency`s Energy Technology Data Exchange (ETDE) and (2) the International Atomic Energy Agency`s International Nuclear Information System (INIS) staff representing the more than 100 countries and organizations that record and index information for the international nuclear information community. ETDE member countries are also members of INIS. Nuclear information prepared for INIS by ETDE member countries is included in the ETDE Energy Database, which contains the online equivalent of the printed INIS Atomindex. Indexing terminology is therefore cooperatively standardized for use in both information systems. This structured vocabulary reflects thscope of international energy research, development, and technological programs. The terminology of this thesaurus aids in subject searching on commercial systems, such as ``Energy Science & Technology`` by DIALOG Information Services, ``Energy`` by STN International and the ``ETDE Energy Database`` by SilverPlatter. It is also the thesaurus for the Integrated Technical Information System (ITIS) online databases of the US Department of Energy.

  11. Becoming an IRB Member | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Becoming an IRB Member Human Subjects Protection Program (HSPP) HSPP Home About ... Contact BER Home Contact Information Human Subjects Protection Program U.S. ...

  12. THE DOE GUIDE TO FINANCIAL ASSISTANCE

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... for the protection of the rights and welfare of human ... Subjects; and 45 CFR Part 46, Protection of Human Subjects. ... that promote ethical business practices, healthful ...

  13. Regulations and Requirements | U.S. DOE Office of Science (SC...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulations and Requirements Human Subjects Protection Program (HSPP) HSPP Home About ... Glossary Abbreviations Contact BER Home Contact Information Human Subjects Protection ...

  14. Abbreviations | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Abbreviations Human Subjects Protection Program (HSPP) HSPP Home About Institutional ... Contact BER Home Contact Information Human Subjects Protection Program U.S. ...

  15. Executive summary and guide to final report: Advisory committee on human radiation experiments

    SciTech Connect (OSTI)

    1995-01-01

    On January 15, 1994, President Clinton appointed the Advisory Committee on Human Radiation Experiments to investigate reports of possibly unethical experiments funded by the government decades ago. The Committee was directed to uncover the history of human radiation experiments during the period 1944 through 1974 and to examine cases in which the government had intentionally released radiation into the environment for research purposes. The Committee was further charged with identifying the ethical and scientific standards for evaluating these events, and with making recommendations to ensure that whatever wrongdoing may have ocurred in the past cannot be repeated. The Committee undertook three projects: A review of how each agency of the federal government that currently conducts or funds research involving human subjects regulates this activity or oversees it; An examination of the documents and consent forms of research projects that are today sponsored by the federal government in order to develop insight into the current status of protections for the rights and interests of human subjects; and, Interviews of nearly 1,900 patients receiving out-patient medical care in private hospitals and federal facilities throughout the country. This booklet provides an overview of the Final Report, summarizing each chapter.

  16. Massively Parallel Models of the Human Circulatory System (Conference...

    Office of Scientific and Technical Information (OSTI)

    Massively Parallel Models of the Human Circulatory System Citation Details In-Document ... Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 59 ...

  17. Fire protection for relocatable structures

    SciTech Connect (OSTI)

    1995-06-01

    This standard supersedes DOE/EV-0043, ``Standard on Fire Protection for Portable Structures.`` It was revised to address the numerous types of relocatable structures, such as trailers, tension-supported structures, and tents being used by DOE and contractors.

  18. Model Fire Protection Assessment Guide

    Office of Energy Efficiency and Renewable Energy (EERE)

    This Assessment guide covers the implementation of the DOE's responsibility of assuring that DOE and the DOE Contractors have established Fire Protection Programs that are at the level required for the area being assessed.

  19. Physical Protection of Classified Matter

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1988-02-03

    The order establishes policy and objectives for physical protection of classified matter. This directive does not cancel another directive. Chg 1, 7-30-93. Canceled by 5632.1C.

  20. CRAD, NNSA- Fire Protection (FP)

    Office of Energy Efficiency and Renewable Energy (EERE)

    CRAD for Fire Protection (FR). Criteria Review and Approach Documents (CRADs) that can be used to conduct a well-organized and thorough assessment of elements of safety and health programs.

  1. Radiation Protection | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Radiation Protection of the Public and the Environment Radiation Protection of the Public and the Environment Water sampling and analysis at Idaho National Lab Water sampling and analysis at Idaho National Lab Idaho National Lab(INL) in partnership with the US Geological Service(USGS) sample, collect and analyze data in order to ensure that exposure to the public and the environment within and around the INL Complex are below the required authorized limits set by DOE. Read more

  2. LANL installs additional protective measures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lab completes additional protections LANL installs additional protective measures Work crews completed additional flood and erosion-control measures this week to reduce the environmental effects of any flash floods following the Las Conchas Fire. July 20, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma

  3. Radiological Protection for DOE Activities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-29

    Establishes radiological protection program requirements that, combined with 10 CFR 835 and its associated implementation guidance, form the basis for a comprehensive program for protection of individuals from the hazards of ionizing radiation in controlled areas. Extended by DOE N 441.3. Cancels DOE 5480.11, DOE 5480.15, DOE N 5400.13, DOE N 5480.11; please note: the DOE radiological control manual (DOE/EH-0256T)

  4. Environmental Protection, Safety, and Health Protection Program for DOE Operations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1981-08-13

    To transmit revised chapters to the subject Order. The following chapter, revised by the Acting Under Secretary's Task Force, supersede previously published chapters as indicated: Chapter I; Chapter V, which now includes former Chapter IV, also superseded; and Chapter VI.

  5. Protection Program Operations (11-18-10)

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-11-18

    This new Order will combine the current requirements of DOE Manuals 470.4-2A, Physical Protection; M 470.4-3A, Protective Force; and 470.4-8, Federal Protective Force, into a single consolidated, streamlined Order.

  6. PROTECT: Enhanced Technology to Protect Against Chemical and Biological

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Terrorism - Energy Innovation Portal Energy Analysis Energy Analysis Find More Like This Return to Search PROTECT: Enhanced Technology to Protect Against Chemical and Biological Terrorism Argonne National Laboratory Contact ANL About This Technology <p class="Default" style="margin: 4pt 0in 2pt; line-height: 8.05pt;"> <i><span style="color: windowtext; font-family: &quot;Franklin Gothic Medium&quot;,&quot;sans-serif&quot;; font-size:

  7. Protection #2: Trap and Remove Sediment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Trap and Remove Sediment Protection 2: Trap and Remove Sediment The 3 Protections Defense in Depth August 1, 2013 Sediment behind LA Canyon weir is sampled and excavated...

  8. Hitec Power Protection | Open Energy Information

    Open Energy Info (EERE)

    search Name: Hitec Power Protection Place: Almelo, Netherlands Zip: 7602 Product: UPS flywheel systems. References: Hitec Power Protection1 This article is a stub. You can help...

  9. Environmental Protection Agency: Handbook for Developing Watershed...

    Open Energy Info (EERE)

    Environmental Protection Agency: Handbook for Developing Watershed Plans to Restore and Protect Our Waters Jump to: navigation, search OpenEI Reference LibraryAdd to library...

  10. California Environmental Protection Agency | Open Energy Information

    Open Energy Info (EERE)

    Agency Jump to: navigation, search Logo: California Environmental Protection Agency Name: California Environmental Protection Agency Address: 1001 I Street, PO Box 2815 Place:...

  11. Nationwide: National Fire Protection Association Provides Training...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    National Fire Protection Association Provides Training to First Responders on EVsPEVs Nationwide: National Fire Protection Association Provides Training to First Responders on...

  12. Nationwide: National Fire Protection Association Provides Training...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Nationwide: National Fire Protection Association Provides Training to First Responders on EVsPEVs Nationwide: National Fire Protection Association Provides Training to First...

  13. Voluntary Protection Program Onsite Review, Bechtel National...

    Office of Environmental Management (EM)

    Review, Waste Treatment Project - May 2006 Voluntary Protection Program Onsite Review, Waste Treatment Plant Construction Project - June 2010 Voluntary Protection Program Onsite...

  14. Shanghai Green Environmental Protection Energy Company Ltd |...

    Open Energy Info (EERE)

    Green Environmental Protection Energy Company Ltd Jump to: navigation, search Name: Shanghai Green Environmental Protection Energy Company Ltd Place: Shanghai, Shanghai...

  15. Washington River Protection Solutions - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protection Solutions, LLC logo The operation of maintaining the underground waste storage tanks at Hanford falls under the jurisdiction of Washington River Protection...

  16. Radiation Protection and Safety Training | Environmental Radiation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Protection and Safety Training (3 hrs) Instructors: John Seaman and Neil Miller ... with an introduction to the fundamentals of ionizing radiation protection and safety. ...

  17. Degradation Mechanisms and Development of Protective Coatings...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mechanisms and Development of Protective Coatings for TES and HTF Containment Materials Degradation Mechanisms and Development of Protective Coatings for TES and HTF Containment ...

  18. Archaeological Resources Protection Act | Open Energy Information

    Open Energy Info (EERE)

    Resources Protection Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Archaeological Resources Protection ActLegal...

  19. Archaeological Resources Protection Act | Open Energy Information

    Open Energy Info (EERE)

    Resource Protection Act) Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Archaeological Resources Protection ActLegal...

  20. 10 CFR 835- Occupational Radiation Protection

    Office of Energy Efficiency and Renewable Energy (EERE)

    The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

  1. Voluntary Protection Program - Related Links | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - Related Links Voluntary Protection Program - Related Links VPPPA - The Voluntary Protection Programs Participants' Association, a non- profit organization is leading the way in ...

  2. Sinosteel Tiancheng Environmental Protection Science and Technology...

    Open Energy Info (EERE)

    Environmental Protection Science and Technology Co Ltd Jump to: navigation, search Name: Sinosteel Tiancheng Environmental Protection Science and Technology Co Ltd Place: Wuhan,...

  3. Fire Protection Engineering Functional Area Qualification Standard...

    Broader source: Energy.gov (indexed) [DOE]

    ... Fire Safety Program" + + + + DOE-STD-1066-99, "Fire Protection Design Criteria" + + + + ... Identify the applicable National Fire Protection Association (NFPA) Code or Standard. c. ...

  4. Voluntary Protection Program Manuals | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Manuals Voluntary Protection Program Manuals Voluntary Protection Program Manual U.S. Department Of Energy Approval Memo Issuing Revised VPP Program Documents (May 2012) Part I: ...

  5. Physical Protection - DOE Directives, Delegations, and Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2A, Physical Protection by jcronin Functional areas: Security, This Manual establishes requirements for the physical protection of interests under the U.S. Department of Energys...

  6. "Human-on-a-Chip" Technology Could Replace Animal Testing | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Maren Hunsberger takes us "Inside the Lab" to learn about the "human-on-a-chip" project. | ... viruses, or drugs on human beings without resorting to animal or even human test subjects? ...

  7. Protective coatings for materials in coal gasification plants. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect (OSTI)

    Not Available

    1994-04-01

    The bibliography contains citations concerning the development and use of protective coatings in coal gasification plants. The citations emphasize materials selection and problems associated with erosion and wear on internal surfaces. Refractory materials for corrosion and erosion protection, high temperature corrosion, and sulfidization corrosion are also included. (Contains 250 citations and includes a subject term index and title list.)

  8. Protection #1: Remove the Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Remove the Source Protection #1: Remove the Source The 3 Protections = Defense in Depth August 1, 2013 Waste being removed from MDA-B inside a metal building Excavation of waste from MDA-B thumbnail of Removing the source means excavating contaminants, sorting these by waste type, and transporting to a disposal area in which contaminants are contained. RELATED IMAGES http://farm8.staticflickr.com/7388/9571274521_679fe1e34a_t.jpg Enlarge http://farm4.staticflickr.com/3726/9571272211_6873a5717f

  9. 1993 Radiation Protection Workshop: Proceedings

    SciTech Connect (OSTI)

    Not Available

    1993-12-31

    The 1993 DOE Radiation Protection Workshop was conducted from April 13 through 15, 1993 in Las Vegas, Nevada. Over 400 Department of Energy Headquarters and Field personnel and contractors from the DOE radiological protection community attended the Workshop. Forty-nine papers were presented in eleven separate sessions: Radiological Control Manual Implementation, New Approaches to Instrumentation and Calibration, Radiological Training Programs and Initiatives, External Dosimetry, Internal Dosimetry, Radiation Exposure Reporting and Recordkeeping, Air Sampling and Monitoring Issues, Decontamination and Decommissioning of Sites, Contamination Monitoring and Control, ALARA/Radiological Engineering, and Current and Future Health Physics Research. Individual papers are indexed separately on the database.

  10. Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R

    SciTech Connect (OSTI)

    Atsmon, Jacob; Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari; Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y.; Bartfeld, Daniel; Shulman, Avidor; Ruderfer, Ilya; Ben-Moshe, Tehila; Shilovitzky, Orit; Soreq, Hermona; Shaaltiel, Yoseph

    2015-09-15

    PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis and treatment of OP poisoning we conducted several preliminary tests, reported in this paper. Intravenous (IV) PRX-105 was administered to mice either before or after exposure to an OP toxin. All mice who received an IV dose of 50 nmol/kg PRX-105, 2 min before being exposed to 1.33 × LD{sub 50} and 1.5 × LD{sub 50} of toxin and 10 min after exposure to 1.5 × LD{sub 50} survived. The pharmacokinetic and toxicity profiles of PRX-105 were evaluated in mice and mini-pigs. Following single and multiple IV doses (50 to 200 mg/kg) no deaths occurred and no significant laboratory and histopathological changes were observed. The overall elimination half-life (t{sub ½}) in mice was 994 (± 173) min. Additionally, a first-in-human study, to assess the safety, tolerability and pharmacokinetics of the compound, was conducted in healthy volunteers. The t{sub ½} in humans was substantially longer than in mice (average 26.7 h). Despite the small number of animals and human subjects who were assessed, the fact that PRX-105 exerts a protective and therapeutic effect following exposure to lethal doses of OP, its favorable safety profile and its relatively long half-life, renders it a promising candidate for treatment and prophylaxis against OP poisoning and warrants further investigation. - Highlights: • PRX-105 is a PEGylated plant-derived recombinant human acetylcholinesterase-R. • PRX-105 is a promising bio-scavenger for organophosphorous toxins at lethal doses. • PRX-105 was shown to protect animals both prophylactically and post-poisoning. • First-in-human study