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1

The use of ex vivo human skin tissue for genotoxicity testing  

SciTech Connect (OSTI)

As a result of the chemical legislation concerning the registration, evaluation, authorization and restriction of chemicals (REACH), and the Seventh Amendment to the Cosmetics Directive, which prohibits animal testing in Europe for cosmetics, alternative methods for safety evaluation of chemicals are urgently needed. Current in vitro genotoxicity assays are not sufficiently predictive for the in vivo situation, resulting in an unacceptably high number of misleading positives. For many chemicals and ingredients of personal care products the skin is the first site of contact, but there are no in vitro genotoxicity assays available in the skin for additional evaluation of positive or equivocal responses observed in regulatory in vitro genotoxicity assays. In the present study ex vivo human skin tissue obtained from surgery was used for genotoxicity evaluation of chemicals by using the comet assay. Fresh ex vivo human skin tissue was cultured in an air–liquid interface and topically exposed to 20 chemicals, including true positive, misleading positive and true negative genotoxins. Based on the results obtained in the present study, the sensitivity, specificity and accuracy of the ex vivo skin comet assay to predict in vivo genotoxicity were 89%, 90% and 89%, respectively. Donor and experimental variability were mainly reflected in the magnitude of the response and not the difference between the presence and absence of a genotoxic response. The present study indicates that human skin obtained from surgery is a promising and robust model for safety evaluation of chemicals that are in direct contact with the skin. -- Highlights: ? We use human skin obtained from surgery for genotoxicity evaluation of chemicals. ? We use the comet assay as parameter for genotoxicity in ex vivo human skin. ? Sensitivity, specificity and accuracy to predict in vivo genotoxins are determined. ? Sensitivity, specificity and accuracy are 89%, 90% and 90%, respectively. ? The method is suitable for evaluation of chemicals that are in contact with skin.

Reus, Astrid A.; Usta, Mustafa [TNO Triskelion BV, Utrechtseweg 48, 3704 HE, Zeist (Netherlands)] [TNO Triskelion BV, Utrechtseweg 48, 3704 HE, Zeist (Netherlands); Krul, Cyrille A.M., E-mail: cyrille.krul@tno.nl [TNO, Utrechtseweg 48, 3704 HE Zeist (Netherlands)

2012-06-01T23:59:59.000Z

2

In vitro dermal absorption of pyrethroid pesticides in human and rat skin  

SciTech Connect (OSTI)

Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment.

Hughes, Michael F., E-mail: hughes.michaelf@epa.go [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Edwards, Brenda C. [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2010-07-15T23:59:59.000Z

3

Simulation of Electron-Beam Irradiation of Skin Tissue Model  

SciTech Connect (OSTI)

Monte Carlo simulation of electrons stopping in liquid water was used to model the penetration and dose distribution of electron beams incident on the full-thickness EpiDermTM skin model (MatTek, Ashland, VA). This 3D tissue model has a fully developed basement membrane separating an epidermal layer of keratinocytes in various stages of differentiation from a dermal layer of fibroblast embedded in collagen. The simulations were motivated by a desire to selectively expose the epidermal layer to low linear-energy-transfer (LET) radiation in the presence of a non-irradiated dermal layer. Using the variable energy electron microbeam at the Pacific Northwest National Laboratory (PNNL) as a model of device characteristics and irradiation geometry, we find that at the highest beam energy available (90 keV), the estimated 90th percentile of penetration remains in the epidermal layer. To investigate the depth-dose distribution, we calculated lineal energy spectra for 10um thick layers near the 10th, 50th, and 90th percentile of penetration by the 90 keV electron beam. Biphasic spectra showed an increasing component of "stoppers" with increasing depth. Despite changes in the lineal energy spectra, the main effect on dose deposition with increasing depth is the screening effect of tissue above the layer of interest.

Miller, John H.; Suleiman, Atef; Chrisler, William B.; Sowa, Marianne B.

2011-01-03T23:59:59.000Z

4

Light scattering by a rough surface of human skin. 1. The luminance factor of reflected light  

SciTech Connect (OSTI)

Based on the analytical solution of Maxwell's equations, we have studied the angular structure of the luminance factor of light reflected by the rough skin surface with large-scale relief elements, illuminated by a directed radiation beam incident at an arbitrary angle inside or outside the medium. The parameters of the surface inhomogeneities are typical of human skin. The calculated angular dependences are interpreted from the point of view of the angular distribution function of micro areas. The results obtained can be used for solving direct and inverse problems in biomedical optics, in particular for determining the depth of light penetration into a biological tissue, for studying the light action spectra on tissue chromophores under the in vivo conditions, for developing diagnostic methods of structural and biophysical parameters of a medium, and for optimising the mechanisms of interaction of light with biological tissues under their noninvasive irradiation through skin. (biomedical optics)

Barun, V V [Belarusian State University of Informatics and Radioelectronics, Minsk (Belarus); Ivanov, A P [B.I.Stepanov Institute of Physics, National Academy of Sciences of Belarus, Minsk (Belarus)

2013-08-31T23:59:59.000Z

5

E-Print Network 3.0 - aged human skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

skin-color to track human body. In this paper, we discuss... on human faces. Using skin color as a feature ... Source: Yang, Jie - Human Computer Interaction Institute & School...

6

E-Print Network 3.0 - aging human skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

skin-color to track human body. In this paper, we discuss... on human faces. Using skin color as a feature ... Source: Yang, Jie - Human Computer Interaction Institute & School...

7

Low power cw-laser signatures on human skin  

SciTech Connect (OSTI)

Impact of cw laser radiation on autofluorescence features of human skin is studied. Two methods of autofluorescence detection are applied: the spectral method with the use of a fibreoptic probe and spectrometer for determining the autofluorescence recovery kinetics at a fixed skin area of {approx}12 mm{sup 2}, and the multispectral visualisation method with the use of a multispectral imaging camera for visualising long-term autofluorescence changes in a skin area of {approx}4 cm{sup 2}. The autofluorescence recovery kinetics after preliminary laser irradiation is determined. Skin autofluorescence images with visible long-term changes - 'signatures' of low power laser treatment are acquired. (application of lasers and laser-optical methods in life sciences)

Lihachev, A; Lesinsh, J; Jakovels, D; Spigulis, J [Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga (Latvia)

2011-01-24T23:59:59.000Z

8

Automatic Tissue Classification for the Human Head from Multispectral MRI  

E-Print Network [OSTI]

1 Automatic Tissue Classification for the Human Head from Multispectral MRI Tolga Tasdizen, David for classifying multispectral MR scans of the human head into nine tissue classes. User initialization is adopted. #12;Chapter 1 Introduction Classification of head magnetic resonance imaging (MRI) data

Utah, University of

9

Total DDT and dieldrin content of human adipose tissue  

SciTech Connect (OSTI)

As far as the authors could ascertain only 4 well-documented analytical studies have been carried out in Australia determining the total DDT and dieldrin content of human adipose tissue. The latest of these studies was published over 16 years ago. Therefore it is timely and important to re-examine the total DDT and dieldrin concentration within the adipose tissue of the Australian population. The present investigation has analyzed 290 samples of human adipose tissue obtained from Westmead Hospital situated in an outer suburb of Sydney, New South Wales for their content of total DDT and dieldrin.

Ahmad, N.; Harsas, W.; Marolt, R.S.; Morton, M.; Pollack, J.K.

1988-12-01T23:59:59.000Z

10

Sensitive method for measurement of telomeric DNA content in human tissues  

DOE Patents [OSTI]

A sensitive method for measurement of telomeric DNA content in human tissue, based upon the ratio of telomeric to centromeric DNA present in the tissue.

Bryant, Jennifer E. (Albuquerque, NM); Hutchings, Kent G. (Albuquerque, NM); Moyzis, Robert K. (Corona Del Mar, CA); Griffith, Jeffrey K. (Cedar Crest, NM)

1999-02-16T23:59:59.000Z

11

A study of heat distribution in human skin: use of Infrared Thermography  

E-Print Network [OSTI]

A study of heat distribution in human skin: use of Infrared Thermography Domoina Ratovoson, Franck of this study is to be able to act quickly on body burns, to avoid propagating lesions due to heat diffusion the temperature change using an infra-red camera. Blood circulation in the veins was seen to clearly influence

Paris-Sud XI, Université de

12

Determination of refractive indices of porcine skin tissues and Intralipid at eight wavelengths  

E-Print Network [OSTI]

the presence of coherent and diffuse reflection near the specular reflection angle. An existing method has been biological tissues, however, light scattering dominates from ultraviolet to near-infrared spectral regions system for accurate measurement of coherent reflectance curves of turbid samples and analyzed

13

Sensitive method for measurement of telomeric DNA content in human tissues  

DOE Patents [OSTI]

This research discloses a sensitive method for measurement of telomeric DNA content in human tissue, based upon the ratio of telomeric to centromeric DNA present in the tissue. 5 figs.

Bryant, J.E.; Hutchings, K.G.; Moyzis, R.K.; Griffith, J.K.

1999-02-16T23:59:59.000Z

14

E-Print Network 3.0 - autologous human tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Medicine ; Materials Science 6 Autologous Heart Valve Tissue Engineering CIP-DATA LIBRARY TECHNISCHE UNIVERSITEIT EINDHOVEN Summary: , the human umbilical cord is...

15

Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro  

SciTech Connect (OSTI)

Lymphatic vessels play an important role in tissue fluid homeostasis, intestinal fat absorption and immunosurveillance. Furthermore, they are involved in pathologic conditions, such as tumor cell metastasis and chronic inflammation. In comparison to blood vessels, the molecular phenotype of lymphatic vessels is less well characterized. Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as compared to blood vascular endothelial cells. Here, we have confirmed these results at the protein level, using Western blot and FACS analysis. Immunofluorescence performed on human skin confirmed that CAR is expressed at detectable levels in lymphatic vessels, but not in blood vessels. To address the functional significance of CAR expression, we modulated CAR expression levels in cultured LECs in vitro by siRNA- and vector-based transfection approaches. Functional assays performed with the transfected cells revealed that CAR is involved in distinct cellular processes in LECs, such as cell adhesion, migration, tube formation and the control of vascular permeability. In contrast, no effect of CAR on LEC proliferation was observed. Overall, our data suggest that CAR stabilizes LEC-LEC interactions in the skin and may contribute to lymphatic vessel integrity.

Vigl, Benjamin; Zgraggen, Claudia; Rehman, Nadia; Banziger-Tobler, Nadia E.; Detmar, Michael [Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, CH-8093 Zurich (Switzerland); Halin, Cornelia [Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, CH-8093 Zurich (Switzerland)], E-mail: cornelia.halin@pharma.ethz.ch

2009-01-15T23:59:59.000Z

16

Mechanical and biochemical properties of human cervical tissue  

E-Print Network [OSTI]

The mechanical integrity of cervical tissue is crucial for maintaining a healthy gestation. Altered tissue biochemistry can cause drastic changes in the mechanical properties of the cervix and contribute to premature ...

Myers, Kristin M

2005-01-01T23:59:59.000Z

17

A Probabilistic Model for the Human Skin Color T.S. Caetano and D.A.C. Barone  

E-Print Network [OSTI]

,barone}@inf.ufrgs.br _____________________________________________ Abstract We present a multivariate statistical model to represent the human skin color. In our approach part in a fully automated facial analysis system, the first important step in recognizing faces to detect faces [1-6]. However, it is a well-known fact that the majority of images acquired today

Caetano, Tiberio

18

r Human Brain Mapping 32:382396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue  

E-Print Network [OSTI]

r Human Brain Mapping 32:382­396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue Segmentation-quality magnetic resonance (MR) images of neonatal brains is largely ham- pered by their characteristically small head size and insufficient tissue contrast. As a result, subsequent image processing and analysis

Utah, University of

2011-01-01T23:59:59.000Z

19

ATHENA, the Advanced Tissue-engineered Human Ectypal Network...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ectypal Network Analyzer project team, is developing four human organ constructs-liver, heart, lung and kidney-that are based on a significantly miniaturized platform. 3:22 - 2 -...

20

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation. |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces andMapping theEnergy Storage EnergyLaboratoryPortalTapping Into

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

IEEE JOURNAL OF QUANTUM ELECTRONICS, VOL. 40, NO. 1, JANUARY 2004 69 Modeling of Skin Tissue Ablation by Nanosecond  

E-Print Network [OSTI]

results. Index Terms--Biological tissues, biomedical applications of optical radiation, laser ablation Ablation by Nanosecond Pulses From Ultraviolet to Near-Infrared and Comparison With Experimental Results in a broad optical spectrum is of fundamental importance to the understanding of laser-tissue interaction

22

Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5  

SciTech Connect (OSTI)

Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5. Gap27 increased scrape-wound closure in normal glucose and insulin (NGI) and to a lesser extent in high glucose and insulin (HGI). IGF-I enhanced scrape-wound closure in keratinocytes whereas IGFBP-5 inhibited this response. Gap27 overcame the inhibitory effects of IGFBP-5 on IGF-I activity. Connexin-mediated communication (CMC) was reduced in HGI, despite raised Cx43, and Gap27 significantly decreased CMC in NGI and HGI. IGF-I and IGFBP-5 did not affect CMC. IGF-I increased keratinocyte proliferation in NGI, and Gap27 increased proliferation in NGI to a greater extent than in HGI. We conclude that IGF-I and Gap27 stimulate scrape-wound closure by independent mechanisms with Gap27 inhibiting Cx43 function. Gap27 can enhance wound closure in diabetic conditions, irrespective of the IGF-I:IGFBP-5 balance. - Highlights: ? Human organotypic and keratinocyte ‘diabetic’ skin models were used to demonstrate the ability of Gap27 to improve scrape-wound closure. ? Gap27 enhanced scrape-wound closure by reducing Cx43-mediated communication, whereas IGFBP-5 retarded cell migration. ? IGF-I and IGFBP-5 did not affect connexin-mediated pathways. ? Gap27 can override altered glucose, insulin, IGF-I, and IGFBP-5 in ‘diabetic’ skin models and thus has therapeutic potential.

Wright, Catherine S.; Berends, Rebecca F. [Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA (United Kingdom); Flint, David J. [Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE (United Kingdom); Martin, Patricia E.M., E-mail: Patricia.Martin@gcu.ac.uk [Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA (United Kingdom)

2013-02-15T23:59:59.000Z

23

Regulation of cyclic AMP phosphodiesterase from human lung tissue by nucleosides and nucleotides  

E-Print Network [OSTI]

REGULATION OF CYCLIC AMP PHOSPHODIESTERASE FROM HUMAN LUNG TISSUE BY NUCLEOSIDES AND NUCLEOTIDES A Thesis by WILLIAM FREDRICK GLASS, II Submitted to the Graduate College oi Texas AlkM University in partial fulfillment of the requirement... Chairman of Advisory Committee: Dr. John B. Moore, Jr. Cyclic nucleotide levels are important modulators of the re- les. se snd effects on target tissues of mediators of allergi?. bronchial asthma. Agents that cause a rise in cyclic AMP levels inhibit...

Glass, William Fredrick

1978-01-01T23:59:59.000Z

24

Demonstration of tyrosinase in the vitiligo skin of human beings by a sensitive fluorometric method as well as by 14C(U)-L-tyrosine incorporation into melanin  

SciTech Connect (OSTI)

Tyrosinase activity (Monophenol, dihydroxyphenylalanine: oxygen oxidoreductase EC 1.14.18.1) in vitiligo and normal epidermal homogenates of skin from human beings was measured by estimating beta 3,4-dihydroxyphenylalanine (dopa) by a highly sensitive fluorometric method described in this paper. The tyrosine activity in the vitiligo skin was about 4 to 37% of corresponding normal skin. The activity of tyrosinase in normal human skin from different individuals and from different regions of the body was in the range of 4 to 140 picomoles of beta 3,4-dihydroxyphenylalanine formed per min/mg protein of epidermal homogenate. The enzyme from vitiligo and normal skin was severely inhibited by substance(s) of low molecular weight. The enzyme exhibits a lag of about 4 hr in the absence of added beta 3,4-dihydroxyphenylalanine and 1 hr in presence of 5 microM dopa. Tyrosinase from the normal and vitiligo skin was inhibited by excess concentration of tyrosine. The homogenates from vitiligo skin could synthesize melanin from C14(U)-L-Tyrosine. The rate of tyrosine incorporation into melanin by the epidermal homogenates is increased by 3,4-dihydroxyphenylalanine (dopa) disproportionate to its effect on tyrosinase activity. Based on the data presented in this paper it is concluded that melanocytes are present in the vitiligo skin. A tentative hypothesis is put forward to explain the lack of melanin synthesis by the vitiligo skin under in vivo conditions, although melanocytes are present.

Husain, I.; Vijayan, E.; Ramaiah, A.; Pasricha, J.S.; Madan, N.C.

1982-03-01T23:59:59.000Z

25

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells  

SciTech Connect (OSTI)

Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model. MSC from human bone marrow and adipose tissue represent very similar cell populations with comparable phenotypes. Adipose tissue is abundant and easily accessible and could thus also harbor cells with the potential to differentiate in insulin producing cells. We isolated human adipose tissue-derived MSC from four healthy donors. During the proliferation period, the cells expressed the stem cell markers nestin, ABCG2, SCF, Thy-1 as well as the pancreatic endocrine transcription factor Isl-1. The cells were induced to differentiate into a pancreatic endocrine phenotype by defined culture conditions within 3 days. Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin.

Timper, Katharina [Department of Research, University Hospital, Basel (Switzerland); Seboek, Dalma [Department of Research, University Hospital, Basel (Switzerland); Eberhardt, Michael [Department of Research, University Hospital, Basel (Switzerland); Linscheid, Philippe [Department of Research, University Hospital, Basel (Switzerland); Christ-Crain, Mirjam [Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Keller, Ulrich [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Mueller, Beat [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Zulewski, Henryk [Department of Research, University Hospital, Basel (Switzerland) and Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland)]. E-mail: henryk.zulewski@unibas.ch

2006-03-24T23:59:59.000Z

26

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide  

SciTech Connect (OSTI)

Dermal exposure to the vesicant sulfur mustard causes marked inflammation and tissue damage. Basal keratinocytes appear to be a major target of sulfur mustard. In the present studies, mechanisms mediating skin toxicity were examined using a mouse skin construct model and a full-thickness human skin equivalent (EpiDerm-FT{sup TM}). In both systems, administration of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide (CEES, 100-1000 {mu}M) at the air surface induced mRNA and protein expression of heat shock proteins 27 and 70 (Hsp27 and Hsp70). CEES treatment also resulted in increased expression of caveolin-1, the major structural component of caveolae. Immunohistochemistry revealed that Hsp27, Hsp70 and caveolin-1 were localized in basal and suprabasal layers of the epidermis. Caveolin-1 was also detected in fibroblasts in the dermal component of the full thickness human skin equivalent. Western blot analysis of caveolar membrane fractions isolated by sucrose density centrifugation demonstrated that Hsp27 and Hsp70 were localized in caveolae. Treatment of mouse keratinocytes with filipin III or methyl-{beta}-cyclodextrin, which disrupt caveolar structure, markedly suppressed CEES-induced Hsp27 and Hsp70 mRNA and protein expression. CEES treatment is known to activate JNK and p38 MAP kinases; in mouse keratinocytes, inhibition of these enzymes suppressed CEES-induced expression of Hsp27 and Hsp70. These data suggest that MAP kinases regulate Hsp 27 and Hsp70; moreover, caveolae-mediated regulation of heat shock protein expression may be important in the pathophysiology of vesicant-induced skin toxicity.

Black, Adrienne T. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Hayden, Patrick J. [MatTek Corporation, Ashland, MA (United States); Casillas, Robert P. [Battelle Memorial Institute, Columbus, OH (United States); Heck, Diane E. [Environmental Health, New York Medical College, Valhalla, NY (United States); Gerecke, Donald R. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Sinko, Patrick J. [Pharmaceutics, Rutgers University, Piscataway, NJ (United States); Laskin, Debra L. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Laskin, Jeffrey D., E-mail: jlaskin@eohsi.rutgers.edu [Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ (United States)

2011-06-01T23:59:59.000Z

27

Green tea polyphenol, (?)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting ?-catenin signaling  

SciTech Connect (OSTI)

The green tea polyphenol, (?)-epigallocatechin-3-gallate (EGCG), has been shown to have anti-carcinogenic effects in several skin tumor models, and efforts are continued to investigate the molecular targets responsible for its cytotoxic effects to cancer cells. Our recent observation that ?-catenin is upregulated in skin tumors suggested the possibility that the anti-skin carcinogenic effects of EGCG are mediated, at least in part, through its effects on ?-catenin signaling. We have found that treatment of the A431 and SCC13 human skin cancer cell lines with EGCG resulted in reduced cell viability and increased cell death and that these cytotoxic effects were associated with inactivation of ?-catenin signaling. Evidence of EGCG-induced inactivation of ?-catenin included: (i) reduced accumulation of nuclear ?-catenin; (ii) enhanced levels of casein kinase1?, reduced phosphorylation of glycogen synthase kinase-3?, and increased phosphorylation of ?-catenin on critical serine{sup 45,33/37} residues; and (iii) reduced levels of matrix metalloproteinase (MMP)-2 and MMP-9, which are down-stream targets of ?-catenin. Treatment of cells with prostaglandin E2 (PGE{sub 2}) enhanced the accumulation of ?-catenin and enhanced ?-catenin signaling. Treatment with either EGCG or an EP2 antagonist (AH6809) reduced the PGE{sub 2}-enhanced levels of cAMP, an upstream regulator of ?-catenin. Inactivation of ?-catenin by EGCG resulted in suppression of cell survival signaling proteins. siRNA knockdown of ?-catenin in A431 and SCC13 cells reduced cell viability. Collectively, these data suggest that induction of cytotoxicity in skin cancer cells by EGCG is mediated by targeting of ?-catenin signaling and that the ?-catenin signaling is upregulated by inflammatory mediators. - Highlights: • EGCG inhibits cancer cell viability through inactivation of ?-catenin signaling. • Inactivation of ?-catenin involves the downregulation of inflammatory mediators. • EGCG inactivates ?-catenin in skin cancer cells by inhibition of cAMP and PGE{sub 2}. • siRNA knockdown of ?-catenin or COX-2 reduces the viability of cancer cells.

Singh, Tripti [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Katiyar, Santosh K., E-mail: skatiyar@uab.edu [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Birmingham Veterans Affairs Medical Center, Birmingham, AL 35233 (United States)

2013-12-01T23:59:59.000Z

28

Thermal Modeling and Experimental Validation of Human Hair and Skin Heated by Broadband Light  

E-Print Network [OSTI]

distribution within the hair follicle is highly non-uniform: the minimum temperature occurs at the follicle Sun, PhD,1 Alex Chaney,1 Robert Anderson, PhD,2 and Guillermo Aguilar, PhD 1 * 1 Department:(a)determinetheoveralleffectofPPxonskinhumidi- tyandassociatedskinopticalproperties,and;(b)developaPT numerical model to study the spatial and temporal hair and skin temperature

Aguilar, Guillermo

29

High expression of arachidonate 15-lipoxygenase and proinflammatory markers in human ischemic heart tissue  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer We found a 17-fold upregulation of ALOX15 in the ischemic heart. Black-Right-Pointing-Pointer Incubation of human muscle cells in hypoxia showed a 22-fold upregulation of ALOX15. Black-Right-Pointing-Pointer We observed increased levels of proinflammatory markers in ischemic heart tissue. Black-Right-Pointing-Pointer Suggesting a link between ischemia and inflammation in ischemic heart biopsies. -- Abstract: A common feature of the ischemic heart and atherosclerotic plaques is the presence of hypoxia (insufficient levels of oxygen in the tissue). Hypoxia has pronounced effects on almost every aspect of cell physiology, and the nuclear transcription factor hypoxia inducible factor-1{alpha} (HIF-1{alpha}) regulates adaptive responses to low concentrations of oxygen in mammalian cells. In our recent work, we observed that hypoxia increases the proinflammatory enzyme arachidonate 15-lipoxygenase (ALOX15B) in human carotid plaques. ALOX15 has recently been shown to be present in the human myocardium, but the effect of ischemia on its expression has not been investigated. Here we test the hypothesis that ischemia of the heart leads to increased expression of ALOX15, and found an almost 2-fold increase in HIF-1{alpha} mRNA expression and a 17-fold upregulation of ALOX15 mRNA expression in the ischemic heart biopsies from patients undergoing coronary bypass surgery compared with non ischemic heart tissue. To investigate the effect of low oxygen concentration on ALOX15 we incubated human vascular muscle cells in hypoxia and showed that expression of ALOX15 increased 22-fold compared with cells incubated in normoxic conditions. We also observed increased mRNA levels of proinflammatory markers in ischemic heart tissue compared with non-ischemic controls. In summary, we demonstrate increased ALOX15 in human ischemic heart biopsies. Furthermore we demonstrate that hypoxia increases ALOX15 in human muscle cells. Our results yield important insights into the underlying association between hypoxia and inflammation in the human ischemic heart disease.

Magnusson, Lisa U.; Lundqvist, Annika [Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (Sweden)] [Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (Sweden); Asp, Julia [Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg (Sweden)] [Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg (Sweden); Synnergren, Jane [Systems Biology Research Center, School of Life Sciences, University of Skoevde, Skoevde (Sweden)] [Systems Biology Research Center, School of Life Sciences, University of Skoevde, Skoevde (Sweden); Johansson, Cecilia Thalen [Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (Sweden)] [Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (Sweden); Palmqvist, Lars [Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg (Sweden)] [Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg (Sweden); Jeppsson, Anders [Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg (Sweden)] [Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg (Sweden); Hulten, Lillemor Mattsson, E-mail: Lillemor.Mattsson@wlab.gu.se [Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (Sweden)

2012-07-27T23:59:59.000Z

30

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide  

SciTech Connect (OSTI)

Sulfur mustard is a potent vesicant that induces inflammation, edema and blistering following dermal exposure. To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT{sup TM}, a commercially available full-thickness human skin equivalent. CEES (100-1000 {mu}M) caused a concentration-dependent increase in pyknotic nuclei and vacuolization in basal keratinocytes; at high concentrations (300-1000 {mu}M), CEES also disrupted keratin filament architecture in the stratum corneum. This was associated with time-dependent increases in expression of proliferating cell nuclear antigen, a marker of cell proliferation, and poly(ADP-ribose) polymerase (PARP) and phosphorylated histone H2AX, markers of DNA damage. Concentration- and time-dependent increases in mRNA and protein expression of eicosanoid biosynthetic enzymes including COX-2, 5-lipoxygenase, microsomal PGE{sub 2} synthases, leukotriene (LT) A{sub 4} hydrolase and LTC{sub 4} synthase were observed in CEES-treated skin equivalents, as well as in antioxidant enzymes, glutathione S-transferases A1-2 (GSTA1-2), GSTA3 and GSTA4. These data demonstrate that CEES induces rapid cellular damage, cytotoxicity and inflammation in full-thickness skin equivalents. These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics.

Black, Adrienne T. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Hayden, Patrick J. [MatTek Corporation, Ashland, MA (United States); Casillas, Robert P. [Battelle Memorial Institute, Columbus, OH (United States); Heck, Diane E. [Environmental Health Sciences, New York Medical College, Valhalla, NY (United States); Gerecke, Donald R. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Sinko, Patrick J. [Pharmaceutics, Rutgers University, Piscataway, NJ (United States); Laskin, Debra L. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Laskin, Jeffrey D., E-mail: jlaskin@eohsi.rutgers.ed [Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ (United States)

2010-12-01T23:59:59.000Z

31

Skin flicks  

E-Print Network [OSTI]

The written and artistic part of this thesis are both separated into the two categories of "SKIN" and "FLICKS". The Artistic part of my thesis consists of five artificial skins made on my body, and a series of video tapes ...

Orth, Margaret A. (Margaret Ann), 1964-

1993-01-01T23:59:59.000Z

32

Efficient elasticity for character skinning with contact and collisions Aleka McAdams1,3  

E-Print Network [OSTI]

-level character skinning system. CR Categories: I.6.8 [Simulation and Modeling]: Types of Simulation--Animation aspect is the production of life-like deformations for soft tissues comprising both humans and animals Animation Studios 2 PDI/DreamWorks 3 University of California, Los Angeles 4 University of Wisconsin

Liblit, Ben

33

Qiyin Fang MECHANISM STUDY OF SKIN TISSUE ABLATION BY NANOSECOND LASER PULSES. (Under the direction of Dr. Xin-Hua Hu)  

E-Print Network [OSTI]

in laser tissue ablation is essential to improve clinical laser applications by reducing collateral damage by nanosecond laser pulses in a wide spectral region from near-infrared to ultraviolet for a clear understanding. Multiple laser and optical configurations have been constructed to generate 9 to 12ns laser pulses

34

Skin contamination dosimeter  

DOE Patents [OSTI]

A technique and device provides absolute skin dosimetry in real time at multiple tissue depths simultaneously. The device uses a phoswich detector which has multiple scintillators embedded at different depths within a non-scintillating material. A digital pulse processor connected to the phoswich detector measures a differential distribution (dN/dH) of count rate N as function of pulse height H for signals from each of the multiple scintillators. A digital processor computes in real time from the differential count-rate distribution for each of multiple scintillators an estimate of an ionizing radiation dose delivered to each of multiple depths of skin tissue corresponding to the multiple scintillators embedded at multiple corresponding depths within the non-scintillating material.

Hamby, David M. (Corvallis, OR); Farsoni, Abdollah T. (Corvallis, OR); Cazalas, Edward (Corvallis, OR)

2011-06-21T23:59:59.000Z

35

Modeling of Human Brain Tissues and Head Injuries Induced by Blast and Ballistic Impact  

E-Print Network [OSTI]

can result from direct impact on the skull, leading to skull fracture and subsequent damage to the brain tissue. Such injuries are penetrating TBIs, which are mainly caused by motor vehicle accidents, sports and work related accidents, and falls...

Kulkarni, Sahil G

2013-11-07T23:59:59.000Z

36

An investigation of the structure-function relationship in human cervical tissue  

E-Print Network [OSTI]

The cervix plays a crucial role in maintaining a healthy pregnancy, acting as a mechanical barrier to hold the fetus inside the uterus during gestation. Altered biochemical and mechanical properties of the cervical tissue ...

Myers, Kristin M

2008-01-01T23:59:59.000Z

37

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals  

E-Print Network [OSTI]

Long intergenic noncoding RNAs (lincRNAs) play diverse regulatory roles in human development and disease, but little is known about their evolutionary history and constraint. Here, we characterize human lincRNA expression ...

Washietl, Stefan

38

Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction  

E-Print Network [OSTI]

The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...

Li, Vivian V. (Vivian Victoria)

2008-01-01T23:59:59.000Z

39

National Human Radiobiological Tissue Repository (NHRTR) at the United States Transuranium and Uranium Registries  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The NHRTR, one component of the USTUR, contains frozen tissues, tissue solutions, microscope slides, and paraffin blocks that were collected by the USTUR at the autopsy of workers with documented intakes of plutonium, americium, uranium, and thorium. The samples are available to qualified scientists for further research. Thousands of frozen, ashed, dried, and plastic embedded bone samples from the radium studies carried out by Argonne National Laboratory, Argonne Cancer Research Hospital, the Massachusetts Institute of Technology, and the New Jersey Radium Research Project are available and linked by case number to de-identified, published case data. These data include the person's source of exposure (dial painter, therapeutic injection, etc.), estimated body burden, radiochemical results, and medical history. Other samples, including organs and whole body donations, have come from volunteer donors who were impacted by elements such as plutonium, throium, etc. See the USTUR website for information on how to apply for research samples or how to become a volunteer donor. [Information taken from http://www.ustur.wsu.edu/NHRTR/index.html#

40

Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde  

SciTech Connect (OSTI)

The number of studies involved in the development of in vitro skin sensitization tests has increased since the adoption of the EU 7th amendment to the cosmetics directive proposing to ban animal testing for cosmetic ingredients by 2013. Several studies have recently demonstrated that sensitizers induce a relevant up-regulation of activation markers such as CD86, CD54, IL-8 or IL-1{beta} in human myeloid cell lines (e.g., U937, MUTZ-3, THP-1) or in human peripheral blood monocyte-derived dendritic cells (PBMDCs). The present study aimed at the identification of new dendritic cell activation markers in order to further improve the in vitro evaluation of the sensitizing potential of chemicals. We have compared the gene expression profiles of PBMDCs and the human cell line MUTZ-3 after a 24-h exposure to the moderate sensitizer cinnamaldehyde. A list of 80 genes modulated in both cell types was obtained and a set of candidate marker genes was selected for further analysis. Cells were exposed to selected sensitizers and non-sensitizers for 24 h and gene expression was analyzed by quantitative real-time reverse transcriptase-polymerase chain reaction. Results indicated that PIR, TRIM16 and two Nrf2-regulated genes, CES1 and NQO1, are modulated by most sensitizers. Up-regulation of these genes could also be observed in our recently published DC-activation test with U937 cells. Due to their role in DC activation, these new genes may help to further refine the in vitro approaches for the screening of the sensitizing properties of a chemical.

Python, Francois [Experimental Product Safety, Procter and Gamble Co., Cosmital SA, Marly (Switzerland); Goebel, Carsten [Product Safety, Human Safety Assessment, Procter and Gamble Service GmbH, Darmstadt (Germany); Aeby, Pierre [Experimental Product Safety, Procter and Gamble Co., Cosmital SA, Marly (Switzerland)], E-mail: pierre_aeby@bluewin.ch

2009-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Effects of FGF-2 on human adipose tissue derived adult stem cells morphology and chondrogenesis enhancement in Transwell culture  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer We investigated effects of FGF-2 on hADSCs. Black-Right-Pointing-Pointer We examine changes in the level of gene expressions of SOX-9, aggrecan and collagen type II and type X. Black-Right-Pointing-Pointer FGF-2 induces chondrogenesis in hADSCs, which Bullet Increasing information will decrease quality if hospital costs are very different. Black-Right-Pointing-Pointer The result of this study may be beneficial in cartilage tissue engineering. -- Abstract: Injured cartilage is difficult to repair due to its poor vascularisation. Cell based therapies may serve as tools to more effectively regenerate defective cartilage. Both adult mesenchymal stem cells (MSCs) and human adipose derived stem cells (hADSCs) are regarded as potential stem cell sources able to generate functional cartilage for cell transplantation. Growth factors, in particular the TGF-b superfamily, influence many processes during cartilage formation, including cell proliferation, extracellular matrix synthesis, maintenance of the differentiated phenotype, and induction of MSCs towards chondrogenesis. In the current study, we investigated the effects of FGF-2 on hADSC morphology and chondrogenesis in Transwell culture. hADSCs were obtained from patients undergoing elective surgery, and then cultured in expansion medium alone or in the presence of FGF-2 (10 ng/ml). mRNA expression levels of SOX-9, aggrecan and collagen type II and type X were quantified by real-time polymerase chain reaction. The morphology, doubling time, trypsinization time and chondrogenesis of hADSCs were also studied. Expression levels of SOX-9, collagen type II, and aggrecan were all significantly increased in hADSCs expanded in presence of FGF-2. Furthermore FGF-2 induced a slender morphology, whereas doubling time and trypsinization time decreased. Our results suggest that FGF-2 induces hADSCs chondrogenesis in Transwell culture, which may be beneficial in cartilage tissue engineering.

Kabiri, Azadeh, E-mail: z_kabiri@resident.mui.ac.ir [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of)] [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of); Esfandiari, Ebrahim, E-mail: esfandiari@med.mui.ac.ir [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of)] [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of); Hashemibeni, Batool, E-mail: hashemibeni@med.mui.ac.ir [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of)] [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of); Kazemi, Mohammad, E-mail: m_kazemi@med.mui.ac.i [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of)] [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of); Mardani, Mohammad, E-mail: mardani@med.mui.ac.ir [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of)] [Department of Anatomical Sciences and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences (Iran, Islamic Republic of); Esmaeili, Abolghasem, E-mail: abesmaeili@yahoo.com [Cell, Molecular and Developmental Biology Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan (Iran, Islamic Republic of)] [Cell, Molecular and Developmental Biology Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan (Iran, Islamic Republic of)

2012-07-27T23:59:59.000Z

42

Friction Induced Skin Tags  

E-Print Network [OSTI]

Duplantis KL, Jones BH. Friction blisters. Pathophysiology,Friction Induced Skin Tags Francisco Allegue MD 1 , Carmenetiopathogenic role for friction. Introduction Skin tags (

Allegue, Francisco; Fachal, Carmen; Pérez-Pérez, Lidia

2008-01-01T23:59:59.000Z

43

United States Transuranium and Uranium Registries: A human tissue research program. USTUR annual report for October 1, 1997 through January 31, 1999  

SciTech Connect (OSTI)

The United States Transuranium and Uranium Registries (USTUR) are a human tissue research program studying the deposition, biokinetics and dosimetry of the actinide elements in humans with the primary goals of providing data fundamental to the verification, refinement, or future development of radiation protection standards for these and other radionuclides, and of determining possible bioeffects on both a macro and subcellular level attributable to exposure to the actinides. This annual report covers October 1, 1997, through January 31, 1999; the reporting period has been extended so that future annual reports will coincide with the period covered by the grant itself.

Ehrhart, Susan M. (ed.); Filipy, Ronald E. (ed.)

1999-10-01T23:59:59.000Z

44

Method and apparatus to measure the depth of skin burns  

DOE Patents [OSTI]

A new device for measuring the depth of surface tissue burns based on the rate at which the skin temperature responds to a sudden differential temperature stimulus. This technique can be performed without physical contact with the burned tissue. In one implementation, time-dependent surface temperature data is taken from subsequent frames of a video signal from an infrared-sensitive video camera. When a thermal transient is created, e.g., by turning off a heat lamp directed at the skin surface, the following time-dependent surface temperature data can be used to determine the skin burn depth. Imaging and non-imaging versions of this device can be implemented, thereby enabling laboratory-quality skin burn depth imagers for hospitals as well as hand-held skin burn depth sensors the size of a small pocket flashlight for field use and triage.

Dickey, Fred M. (Albuquerque, NM); Holswade, Scott C. (Albuquerque, NM)

2002-01-01T23:59:59.000Z

45

PASSAGE OF FISSION PRODUCTS THROUGH THE SKIN OF TUNA  

E-Print Network [OSTI]

. Presumably, radio- active materials contaminating the skin of such fish could enter and spread through the tissues thus contaminating the whole fish. The present study intended to test this assump- tion, considers, resulting in small quantities in the tissues of tuna held in cold brine for as long as almost two months

46

Quercitrin protects skin from UVB-induced oxidative damage  

SciTech Connect (OSTI)

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. - Highlights: • Oxidative stress plays a key role in UV-induced cell and tissue injuries. • Quercitrin decreases ROS generation and restores antioxidants irradiated by UVB. • Quercitrin reduces UVB-irradiated oxidative DNA damage, apoptosis, and inflammation. • Quercitrin functions as an antioxidant against UVB-induced skin injuries.

Yin, Yuanqin [Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang (China); Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Li, Wenqi; Son, Young-Ok; Sun, Lijuan; Lu, Jian; Kim, Donghern; Wang, Xin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Yao, Hua [Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang (China); Wang, Lei; Pratheeshkumar, Poyil; Hitron, Andrew J. [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Luo, Jia [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY (United States); Gao, Ning [Department of Pharmacognos, College of Pharmacy, 3rd Military Medical University, Chongqing (China); Shi, Xianglin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Zhang, Zhuo, E-mail: zhuo.zhang@uky.edu [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States)

2013-06-01T23:59:59.000Z

47

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs  

SciTech Connect (OSTI)

Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. Specific aims apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. The project includes research complementary to NASA/HRP space radiation project.

Michael Cornforth

2012-03-26T23:59:59.000Z

48

Sprayed skin turbine component  

DOE Patents [OSTI]

Fabricating a turbine component (50) by casting a core structure (30), forming an array of pits (24) in an outer surface (32) of the core structure, depositing a transient liquid phase (TLP) material (40) on the outer surface of the core structure, the TLP containing a melting-point depressant, depositing a skin (42) on the outer surface of the core structure over the TLP material, and heating the assembly, thus forming both a diffusion bond and a mechanical interlock between the skin and the core structure. The heating diffuses the melting-point depressant away from the interface. Subsurface cooling channels (35) may be formed by forming grooves (34) in the outer surface of the core structure, filling the grooves with a fugitive filler (36), depositing and bonding the skin (42), then removing the fugitive material.

Allen, David B

2013-06-04T23:59:59.000Z

49

E-Print Network 3.0 - aire activated tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fluorescence imaging of freeze- trapped human cervical tissues Nirmala Ramanujam... distribution within the epithelia and stroma of frozen human cervical tissues at ... Source:...

50

In Vivo characterization of skin using a weiner nonlinear stochastic identification method  

E-Print Network [OSTI]

This paper describes an indentometer device used to identify the linear dynamic and nonlinear properties of skin and underlying tissue using an in vivo test. The device uses a Lorentz force actuator to apply a dynamic force ...

Chen, Yi

51

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating  

E-Print Network [OSTI]

, is generated under conditions known as risk factors for AD, including stroke and traumatic head injury. BK B2 increases I/L B2 BK receptors in AD skin fibroblasts In established human fetal lung fibroblast models of protein kinase C (PKC). We now show that skin fibro- blasts of patients with AD developing around age 35

Steinbach, Joe Henry

52

Neutron skins and neutron stars  

SciTech Connect (OSTI)

The neutron-skin thickness of heavy nuclei provides a fundamental link to the equation of state of neutron-rich matter, and hence to the properties of neutron stars. The Lead Radius Experiment ('PREX') at Jefferson Laboratory has recently provided the first model-independence evidence on the existence of a neutron-rich skin in {sup 208}Pb. In this contribution we examine how the increased accuracy in the determination of neutron skins expected from the commissioning of intense polarized electron beams may impact the physics of neutron stars.

Piekarewicz, J. [Department of Physics, Florida State University, Tallahassee, FL 32306-4350 (United States)

2013-11-07T23:59:59.000Z

53

Mesh Resolution Augmentation using 3D Skin Bank Won-Sook Lee*  

E-Print Network [OSTI]

on a 100-micron resolution scan of plaster cast molds of the actors' faces. Human skin was modeled using, as shown in Figure 1. Each individual is presented with closed eyes and mouth due to the use of plaster

Lee, WonSook

54

Sensitive skins and somatic processing for affective and sociable robots based upon a somatic alphabet approach  

E-Print Network [OSTI]

The sense of touch is one of the most important senses of the human body. This thesis describes the biologically inspired design of "sensitive skins" for two different robotic platforms: Leonardo, a high degree-of-freedom, ...

Stiehl, Walter Daniel, 1980-

2005-01-01T23:59:59.000Z

55

Detecting pornographic images by localizing skin Sotiris Karavarsamisa  

E-Print Network [OSTI]

specialized sub- classes, namely "bikini" / "porn" and "skin" / "non-skin", respectively. The extracted

Blekas, Konstantinos

56

E-Print Network 3.0 - adult human dermis Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering 3 Developing a predictive model of human skin colouring Symon D'Oyly Cotton Summary: Developing a predictive model of human skin colouring Symon D'Oyly Cotton Ela...

57

A critical comparison of human face rendering techniques  

E-Print Network [OSTI]

Human skin exhibits complex light reflectance properties that make it difficult to render realistically. In recent years, many techniques have been introduced to render skin, with varying degrees of complexity and realism. ...

Arizpe, Arturo Andrew

2006-01-01T23:59:59.000Z

58

"Skin Cancer-What to Look For" Rochester Recreation  

E-Print Network [OSTI]

"Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

Goldman, Steven A.

59

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner  

SciTech Connect (OSTI)

The polychlorinated biphenyl group possesses high environmental persistence, leading to bioaccumulation and a number of adverse effects in mammals. Whilst coplanar PCBs elicit their toxic effects through agonism of the aryl hydrocarbon receptor; however, non-coplanar PCBs are not ligands for AhR, but may be ligands for members of the nuclear receptor family of proteins. To better understand the biological actions of non-coplanar PCBs, we have undertaken a systematic analysis of their ability to activate PXR and CAR-mediated effects. Cells were exposed to a range of non-coplanar PCBs (99, 138, 153, 180 and 194), or the coplanar PCB77: Direct activation of PXR and CAR was measured using a mammalian receptor activation assay in human liver cells, with rifampicin and CITCO used as positive controls ligands for PXR and CAR, respectively; activation of target gene expression was examined using reporter gene plasmids for CYP3A4 and MDR1 transfected into liver, intestine and lung cell lines. Several of the non-coplanar PCBs directly activated PXR and CAR, whilst the coplanar PCB77 did not. Non-coplanar PCBs were also able to activate PXR/CAR target gene expression in a substitution- and tissue-specific manner. Non-coplanar PCBs act as direct activators for the nuclear receptors PXR and CAR, and are able to elicit transcriptional activation of target genes in a substitution- and tissue-dependent manner. Chronic activation of PXR/CAR is linked to adverse effects and must be included in any risk assessment of PCBs. -- Highlights: ? Several Non-coplanar PCBs are able to directly activate both PXR and CAR in vitro. ? PCB153 is the most potent direct activator of PXR and CAR nuclear receptors. ? Non-coplanar PCB activation of CYP3A4/MDR1 reporter genes is structure-dependent. ? Non-coplanar PCB activate CYP3A4/MDR1 reporter genes in a tissue-dependent. ? PCB153 is the most potent activator of PXR/CAR target gene in all tissues.

Al-Salman, Fadheela; Plant, Nick, E-mail: N.Plant@Surrey.ac.uk

2012-08-15T23:59:59.000Z

60

Effect of dietary polyunsaturated fatty acids and related nutrients on sebum lipids, and skin and hair coat condition in canines  

E-Print Network [OSTI]

to 7 Table 1.1 Composition (wt%) of skin surface lipids in selected mammals. Although skin surface lipids have been analyzed in over 70 mammalian species, only data from humans and some domestic animals are presented here. Note the marked...

Kirby, Naomi Anne

2005-02-17T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Lasers in Surgery and Medicine 28:113120 (2001) Inuence of Nozzle-to-Skin Distance in Cryogen Spray  

E-Print Network [OSTI]

of dis- tance from the nozzle tip. Results: Size of spray cones and sprayed areas vary with distanceLasers in Surgery and Medicine 28:113±120 (2001) InŻuence of Nozzle-to-Skin Distance in Cryogen, the optimal atomizing nozzle design and operating conditions for cooling human skin remain to be determined

Aguilar, Guillermo

2001-01-01T23:59:59.000Z

62

Turbine vane with high temperature capable skins  

DOE Patents [OSTI]

A turbine vane assembly includes an airfoil extending between an inner shroud and an outer shroud. The airfoil can include a substructure having an outer peripheral surface. At least a portion of the outer peripheral surface is covered by an external skin. The external skin can be made of a high temperature capable material, such as oxide dispersion strengthened alloys, intermetallic alloys, ceramic matrix composites or refractory alloys. The external skin can be formed, and the airfoil can be subsequently bi-cast around or onto the skin. The skin and the substructure can be attached by a plurality of attachment members extending between the skin and the substructure. The skin can be spaced from the outer peripheral surface of the substructure such that a cavity is formed therebetween. Coolant can be supplied to the cavity. Skins can also be applied to the gas path faces of the inner and outer shrouds.

Morrison, Jay A. (Oviedo, FL)

2012-07-10T23:59:59.000Z

63

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog  

SciTech Connect (OSTI)

Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a well-known DNA-damaging agent that has been used in chemical warfare since World War I, and is a weapon that could potentially be used in a terrorist attack on a civilian population. Dermal exposure to high concentrations of SM produces severe, long-lasting burns. Topical exposure to high concentrations of 2-(chloroethyl) ethyl sulfide (CEES), a monofunctional analog of SM, also produces severe skin lesions in mice. Utilizing a genetically engineered mouse strain, Big Blue, that allows measurement of mutation frequencies in mouse tissues, we now show that topical treatment with much lower concentrations of CEES induces significant dose- and time-dependent increases in mutation frequency in mouse skin; the mutagenic exposures produce minimal toxicity as determined by standard histopathology and immunohistochemical analysis for cytokeratin 6 and the DNA-damage induced phosphorylation of histone H2AX (?-H2AX). We attempted to develop a therapeutic that would inhibit the CEES-induced increase in mutation frequency in the skin. We observe that multi-dose, topical treatment with 2,6-dithiopurine (DTP), a known chemical scavenger of CEES, beginning 1 h post-exposure to CEES, completely abolishes the CEES-induced increase in mutation frequency. These findings suggest the possibility that DTP, previously shown to be non-toxic in mice, may be useful as a therapeutic agent in accidental or malicious human exposures to SM. -- Highlights: ? 200 mM 2-(chloroethyl) ethyl sulfide (CEES) induces mutations in mouse skin. ? This dose of CEES is not overtly toxic, as assayed by histopathology. ? 2,6-Dithiopurine (DTP), applied after CEES-treatment, abolishes CEES-mutagenesis. ? This supports the idea that sulfur mustards exhibit long biological half-lives.

Boulware, Stephen [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); Fields, Tammy; McIvor, Elizabeth; Powell, K. Leslie; Abel, Erika L. [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)] [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States); Vasquez, Karen M. [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); MacLeod, Michael C., E-mail: mcmacleod@mdanderson.org [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)

2012-09-01T23:59:59.000Z

64

Near-infrared spectroscopic tissue imaging for medical applications  

DOE Patents [OSTI]

Near infrared imaging using elastic light scattering and tissue autofluorescence are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

Demos; Stavros (Livermore, CA), Staggs; Michael C. (Tracy, CA)

2006-03-21T23:59:59.000Z

65

Near-infrared spectroscopic tissue imaging for medical applications  

DOE Patents [OSTI]

Near infrared imaging using elastic light scattering and tissue autofluorescence are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

Demos, Stavros (Livermore, CA); Staggs, Michael C. (Tracy, CA)

2006-12-12T23:59:59.000Z

66

Confocal Microscopy for Modeling Electron Microbeam Irradiation of Skin  

SciTech Connect (OSTI)

For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the spample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differential tissues. Employing high-resolution confocal microscopy, we have determined the spatial distribution, size, and shape of epidermal kerantinocyte nuclei for the full-thickness EpiDerm skin model (MatTek, Ashland, VA). Application of these data to claculate the microdosimetry and microdistribution of energy deposition by an electron microbeam is discussed.

Miller, John H.; Chrisler, William B.; Wang, Xihai; Sowa, Marianne B.

2011-08-01T23:59:59.000Z

67

Apparatus for testing skin samples or the like  

DOE Patents [OSTI]

An apparatus for testing the permeability of living skin samples has a flat base with a plurality of sample-holding cavities formed in its upper surface, the samples being placed in counterbores in the cavities with the epidermis uppermost. O-rings of Teflon washers are respectively placed on the samples and a flat cover is connected to the base to press the rings against the upper surfaces of the samples. Media to maintain tissue viability and recovery of metabolites is introduced into the lower portion of the sample-holding cavities through passages in the base. Test materials are introduced through holes in the cover plate after assembly of the chamber.

Holland, J.M.

1982-08-31T23:59:59.000Z

68

Tissue Issue Adekunle Raji  

E-Print Network [OSTI]

- Disease-Driven Program BIOREPOSITORIES #12;What Are Tissue ? SPECIMENS: Blood, urine, lavage, aspirate. Initiate then Implement - #12;Pathology Department Institutional Review Board Study require tissue submission. Must engage pathologists and pathology departments. Information exchange, QA Must understand

Contractor, Anis

69

Stationary turbine component with laminated skin  

DOE Patents [OSTI]

A stationary turbine engine component, such as a turbine vane, includes a internal spar and an external skin. The internal spar is made of a plurality of spar laminates, and the external skin is made of a plurality of skin laminates. The plurality of skin laminates interlockingly engage the plurality of spar laminates such that the external skin is located and held in place. This arrangement allows alternative high temperature materials to be used on turbine engine components in areas where their properties are needed without having to make the entire component out of such material. Thus, the manufacturing difficulties associated with making an entire component of such a material and the attendant high costs are avoided. The skin laminates can be made of advanced generation single crystal superalloys, intermetallics and refractory alloys.

James, Allister W. (Orlando, FL)

2012-08-14T23:59:59.000Z

70

A noninvasive skin imaging system Symon Cotton  

E-Print Network [OSTI]

A noninvasive skin imaging system Symon Cotton School of Computer Science, University Of Birmingham arriving at a diagnosis. A previous paper [Cotton and Claridge 1996] presented a model of colour formation­dimensional colour space, is limited to a curved surface [Cotton and Claridge 1996]. As abnormal skin often has a di

Claridge, Ela

71

322 IEEE JOURNAL OF QUANTUM ELECTRONICS, VOL. 37, NO. 3, MARCH 2001 Mechanism Study of Porcine Skin Ablation  

E-Print Network [OSTI]

, biomedical applica- tions of optical radiation, biological tissues, laser ablation, neodymium:YAG lasers identified the Na spectral line at 589 nm in the secondary radiation from the ablated skin sample, spectral analysis. I. INTRODUCTION IN THE progression of less-damaging surgical laser proce- dures

72

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Contracts. Final report  

SciTech Connect (OSTI)

Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. The aims of this work apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. These aims are: to analyze by multi-flour fluorescence in situ hybridization (mFISH) the chromosomes in clonal descendents of individual human fibroblasts that were previously irradiated; to examine irradiated clones from Aim 1 for submicroscopic deletions by subjecting their DNA to comparative genomic hybridization (CGH) microarray analysis; and to flow-sort aberrant chromosomes from clones containing stable radiation-induced translocations and map the breakpoints to within an average resolution of 100 kb using the technique of 'array painting'.

Cornforth, Michael N. [The University of Texas Medical Branch at Galveston, TX (United States)

2013-05-03T23:59:59.000Z

73

autologous serum skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

74

alter skin microcirculation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

75

ameliorate genetic skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

76

Nonlinear stochastic system identification techniques for biological tissues/  

E-Print Network [OSTI]

This research develops a device capable of measuring the nonlinear dynamic mechanical properties of human tissue in vivo. The enabling technology is the use of nonlinear stochastic system identification techniques in ...

Chen, Yi, S.M. Massachusetts Institute of Technology

2010-01-01T23:59:59.000Z

77

Beyond the skin bag: on the moral responsibility of extended agencies  

E-Print Network [OSTI]

and extended agency The view of the subject as only the human individual is known as methodological individualism. This theory holds that subjects are human beings entirely contained in their “skin bags” (Clark 2003), that maintain their identity... to ride a bicycle. “Be careful not to run into people or things, don’t crash your bike or hurt yourself, and especially don’t ride into the street without looking.” Her responsibility with the bicycle is, however, considerably less momentous than...

Hanson, F. Allan

2009-03-01T23:59:59.000Z

78

Skin thickness effects on in vivo LXRF  

SciTech Connect (OSTI)

The analysis of lead concentration in bone utilizing LXRF can be adversely effected by overlying issue. A quantitative measure of the attenuation of the 10.5 keV Pb L a x-ray signal by skin and skin equivalent plastic has been conducted. Concentration ranges in plaster of Paris and goat bone from 7 to 90 ppm with attenuators of Lucite{reg_sign} and pig skin were examined. It is concluded that no quantitative or semi quantitative analysis can be achieved if overlying sue thickness exceeds 3 mm for Ph concentrations of less than 30 porn Ph in bone.

Preiss, I.L.; Washington, W. II [Rensselaer Polytechnic Inst., Troy, NY (United States)

1995-12-31T23:59:59.000Z

79

Skin friction for steel piles in sand  

E-Print Network [OSTI]

SkiN FRICTION FOR STEZL PIIZS IN SAND A Theeia by I. H. Sulaiman Submittei io the graduate College of t, he Texan AAB Univen-ity in Ixantial fulfil. ment of bhe zequiremenbu for the degree of NASTZR 0F SCISNCZ May 196'7 bsrjor Subject...: Civil Engineering SKIN FRICTION FOR STEEL PILES IN SAND A Thesis by I. H. Sulaiman Approved as to style and content by: Chairman of C mmittee Head of Department Memb Member 111 Skin Friction For Steel Piles in Sand (May 1967) Ibr shim Hikmat...

Sulaiman, Ibrahim Hikmat

2012-06-07T23:59:59.000Z

80

Phosphoproteomics profiling of human skin fibroblast cells reveals pathways  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - September 2006 TheSteven AshbyDepartmentPersonnelAdams5EMSLBluetheoreticaland

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Tissue-like phantoms  

DOE Patents [OSTI]

The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal imaging objects (e.g., beads) can be inserted into the phantoms to mimic tissue pathologies, such as cancer, or merely to serve as calibration standards. These objects can be imaged using one, two, or more (e.g., four) different imaging modalities (e.g., x-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and near-infrared (NIR) fluorescence) simultaneously.

Frangioni, John V. (Wayland, MA); De Grand, Alec M. (Boston, MA)

2007-10-30T23:59:59.000Z

82

E-Print Network 3.0 - activates human inducible Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

fetal tissue; (B) the tissue may have been obtained pursuant to a spontaneous or induced abortion... , and to the Committee on Labor and Human Resources of the ... Source:...

83

Negative skin friction at Keehi interchange  

E-Print Network [OSTI]

is assumed to be the sum of the structural load, gt, a drag force, F'n, due to the fill within the pile group and a drag force F'n due to the negative skin friction of the soft layer. F = ()t + F'n + F"n (2. 1) where F'n is the weight of fill carried... of this method for an actual case. 2. 2. 3 Brome Brome (1969) describes the state of the practice in Sweden for the calculation of drag forces on piles due to negative skin friction. In Sweden most piles are driven to rock. The compression of the pile...

Porwoll, Hubert

2012-06-07T23:59:59.000Z

84

Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease  

E-Print Network [OSTI]

, and therein is regulated by injury. In the case of CNS demyelinating disease, K6 expression in CNS occurs in a tissue- specific fashion and are differentially regulated in response to CNS injury. While the human peripheral tissue. In a murine model of human CNS demyelinating inflammatory disease induced by Theiler's pi

Blaber, Michael

85

Human impacts on Caribbean coral reef ecosystems  

E-Print Network [OSTI]

The tissue biomass of common Caribbean reef corals. xv VITAJackson, JBC. “Structure of Caribbean coral reef communitiesHuman impacts on Caribbean coral reef ecosystems by Marah

Hardt, Marah Justine

2007-01-01T23:59:59.000Z

86

Tissue-material interactions : bioadhesion and tissue response  

E-Print Network [OSTI]

Diverse interactions between soft tissues and implanted biomaterials directly influence the success or failure of therapeutic interventions. The nature and extent of these interactions strongly depend on both the tissue ...

Shazly, Tarek (Tarek Michael)

2009-01-01T23:59:59.000Z

87

Space radiation-induced bystander signaling in 2D and 3D skin tissue models  

E-Print Network [OSTI]

Space radiation poses a significant hazard to astronauts on long-duration missions, and the low fluences of charged particles characteristic of this field suggest that bystander effects, the phenomenon in which a greater ...

Lumpkins, Sarah B

2012-01-01T23:59:59.000Z

88

Active skin for turbulent drag reduction  

E-Print Network [OSTI]

pursued is "micro" in the sense that only micro-scale wave amplitudes (order of 30[]m) and energy inputs are sufficient to produce significant benefits. Two actuation principles are proposed and analyzed and different skin designs based on these two...

Mani, Raghavendran

2002-01-01T23:59:59.000Z

89

Preventive Skin Care Fact or Fiction?  

E-Print Network [OSTI]

and colors Many are birthmarks http://www.skinsight.com/images/dx/webInfant/congenitalMelanocyticNevus_33234 by skin biopsy to make sure not cancer http://www.skinsight.com/images/dx/webInfant/congenital://www.skincancer.org/understanding-uva-and-uvb.html #12;Practice GOOD habits! · Reapply sunscreen if: ­ Sweating ­ Swimming in water ­ Doing any activity

Goldman, Steven A.

90

Skin Bleaching in Jamaica: A Colonial Legacy  

E-Print Network [OSTI]

of Eurocentric values and a denigration of Afrocentric values in many facets of life, specifically in the promotion of light skin as an indicator of beauty and social status. The purpose of this study was to examine the psychological and socio-cultural factors...

Robinson, Petra Alaine

2012-07-16T23:59:59.000Z

91

Self-cleaning skin-like prosthetic polymer surfaces  

DOE Patents [OSTI]

An external covering and method of making an external covering for hiding the internal endoskeleton of a mechanical (e.g., prosthetic) device that exhibits skin-like qualities is provided. The external covering generally comprises an internal bulk layer in contact with the endoskeleton of the prosthetic device and an external skin layer disposed about the internal bulk layer. The external skin layer is comprised of a polymer composite with carbon nanotubes embedded therein. The outer surface of the skin layer has multiple cone-shaped projections that provide the external skin layer with superhydrophobicity. The carbon nanotubes are preferably vertically aligned between the inner surface and outer surface of the external skin layer in order to provide the skin layer with the ability to transmit heat. Superhydrophobic powders may optionally be used as part of the polymer composite or applied as a coating to the surface of the skin layer to enhance superhydrophobicity.

Simpson, John T. (Clinton, TN); Ivanov, Ilia N. (Knoxville, TN); Shibata, Jason (Manhattan Beach, CA)

2012-03-27T23:59:59.000Z

92

Vaccine delivery with microneedle skin patches in nonhuman primates  

E-Print Network [OSTI]

Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

Li, Adrienne V

93

The study of skin permeation mechanism and terpene-skin lipid interaction via nuclear magnetic resonance  

E-Print Network [OSTI]

, lipid extraction, etc. In our case, the interaction between a terpene and a lipid was examinedwith nuclear magnetic resonance (NMR), which aims to provide some insight to enhancement in skin permeation. Palmitic acid (Fig 1), a 16-carbon fatty acid... and oxides were able to producea greater ??. National University of Singapore, 2006 PS77 -The Study of Skin Permeation Mechanism and Terpene-Lipid Interaction via Nuclear Magnetic Resonance Perry Fung Chye Lim a, Xiang Yang Liu b, Meng Huang a, Paul Chi...

Lim, P. F. C.; Liu, Xiang Yang; Huang, Meng; Ho, P. C. L.; Chan, S. Y.

2006-10-27T23:59:59.000Z

94

absorption skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

absorption skin First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Healthy Skin Matters Normal Skin...

95

3D Tissue Scaffolds BIOMATERIALS  

E-Print Network [OSTI]

3D Tissue Scaffolds BIOMATERIALS Our goal is to develop measurement tools and reference materials for assessing the impact of the physical and chemical properties of 3D tissue scaffolds on cellular response. These tools will be used to explore the relationship between cellular response on 2D surfaces to that in 3D

96

Help:Skins | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Power BasicsGermany: EnergyPower Finance Jump737002°,HavanaElorblocks JumpSkins

97

Skin temperature of the sea as determined by radiometer  

E-Print Network [OSTI]

) Differences Temperature Vapor Press Skin Skin Bkt Skin Bkt -Bkt -Air -Air -Air -Air 120100 120200 120400 120500 1 20600 1 20700 1 20800 1 20900 1 21000 130100 130200 130300 130400 130500 130600 130700 130800 131000 131100 . 6235 . 6732.... FORTRAN program. 57 6. Stepwise analysis of error in radiation temperature of the sea. 65 LIST OF FIGURES Number Page 1. Tracks of Cruise 62 -H-10 along which radiation data were obtained, 2. Comparison of i. nfrared emissivities of water vapor. 14...

Boudreau, Robert Donald

2012-06-07T23:59:59.000Z

98

Turbine blade having a constant thickness airfoil skin  

DOE Patents [OSTI]

A turbine blade is provided for a gas turbine comprising: a support structure comprising a base defining a root of the blade and a framework extending radially outwardly from the base, and an outer skin coupled to the support structure framework. The skin has a generally constant thickness along substantially the entire radial extent thereof. The framework and the skin define an airfoil of the blade.

Marra, John J

2012-10-23T23:59:59.000Z

99

allotransplanted vascularized skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Optimum pulse duration and radiant exposure for vascular laser therapy of dark port-wine skin: a theoretical study Engineering Websites Summary: Optimum pulse duration and...

100

analyzing skin conductance: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

coupling between each tactile sensing chip and a ground Shinoda, Hiroyuki 8 HandWave: Design and Manufacture of a Wearable Wireless Skin Conductance Computer Technologies and...

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Mechanisms of mesothelial tissue lubrication  

E-Print Network [OSTI]

In the pleural space, sliding between the lung and chest wall induces shear stress that could damage the delicate mesothelial cells covering the tissue surfaces. Normally, the pleural space, which is filled with fluid, is ...

Lin, Judy Li-Wen

2006-01-01T23:59:59.000Z

102

allergic skin test: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

allergic skin test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Skin Microbiome in Healthy and...

103

Neutron skin of 208 Pb in consistency with  

E-Print Network [OSTI]

Neutron skin of 208 Pb in consistency with neutron star observations K. Miyazaki E-mail: miyazakiro as varying the neutron radius of 208Pb. The neutron skin thickness Sn is determined in the comparison with the astronomical observations of massive neutron stars (NSs), the standard scenario of NS cooling

104

Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy  

E-Print Network [OSTI]

Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

Smith, Elizabeth Brooks

2009-05-15T23:59:59.000Z

105

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, J.W.

1993-06-08T23:59:59.000Z

106

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

1993-01-01T23:59:59.000Z

107

Albumin extravasation rates in tissues of anesthetized and unanesthetized rats  

SciTech Connect (OSTI)

Bovine serum albumin (BSA) labeled with /sup 131/I was injected intravenously in chronically prepared, unanesthetized rats and into pentobarbital-anesthetized rats that had received 2 ml 5% BSA to help sustain plasma volume. Initial uptake rates (clearances) in skin, skeletal muscles, diaphragm, and heart (left ventricle) were measured over 1 h. BSA labeled with /sup 125/I was injected terminally to correct for intravascular /sup 131/I-BSA. Observed clearances were in the following order in both groups of animals: heart much greater than diaphragm approximately equal to skin greater than resting skeletal muscles. Differences between unanesthetized and anesthetized animals were small and inconsistently directed. Our results suggest that the lower albumin clearances reported in the literature for anesthetized rats are not the result of their immobility or any direct effect of anesthesia on albumin transport in these tissues. The lower transport rates appear to result indirectly from changes produced by anesthesia and/or surgery in controllable parameters such as plasma volume and intravascular protein mass.

Renkin, E.M.; Joyner, W.L.; Gustafson-Sgro, M.; Plopper, G.; Sibley, L.

1989-05-01T23:59:59.000Z

108

Mechanistic investigation of skin barrier perturbation induced by surfactants in the presence of humectants  

E-Print Network [OSTI]

The stratum corneum (SC) of the skin functions as a barrier between the body and the environment. Surfactants such as Sodium Dodecyl Sulfate (SDS) are used in skin cleansers and in skin-care formulations because of their ...

Ghosh, Saswata

2007-01-01T23:59:59.000Z

109

E-Print Network 3.0 - avoidable skin cancers Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: avoidable skin cancers Page: << < 1 2 3 4 5 > >> 1 "Skin Cancer-What to Look For" Rochester Recreation Summary: "Skin Cancer- What to Look For"...

110

Skin Disease In Dermatomyositis -- What Patients And Their Families Often Want To Know  

E-Print Network [OSTI]

on the upper eyelids (heliotrope erythema), the cheeks ofcharacteristic violet (heliotrope) skin color seen in whitecharacteristic violet (heliotrope) skin color seen in white

Sontheimer, Richard D.

2002-01-01T23:59:59.000Z

111

autologous fibrin-based skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

112

atopic dermatitis-like skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

113

acinetobacter baumannii-associated skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

114

E-Print Network 3.0 - anomalous skin effect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AT 35 GHZ Summary: us well into the anomalous skin effect regime. To facilitate comparison with the static resistivity... , we have used the the anomalous skin effect formula...

115

Influence of Tissue Conductivity Inhomogeneity and Anisotropy on EEG/MEG based  

E-Print Network [OSTI]

source in the brain using a volume-conduction model of the head. The associated differential equations in the Human Brain #12;Die Deutsche Bibliothek - CIP-Einheitsaufnahme Wolters, Carsten Hermann: Influence of Tissue Conductivity Inhomogeneity and Anisotropy on EEG/MEG based Source Localization in the Human Brain

Utah, University of

116

Engineering human hepatic tissue for modeling liver-stage malaria  

E-Print Network [OSTI]

The Plcsmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, ...

Ng, Shengyong

2014-01-01T23:59:59.000Z

117

Bio-inspired nanocomposite assemblies as smart skin components.  

SciTech Connect (OSTI)

There is national interest in the development of sophisticated materials that can automatically detect and respond to chemical and biological threats without the need for human intervention. In living systems, cell membranes perform such functions on a routine basis, detecting threats, communicating with the cell, and triggering automatic responses such as the opening and closing of ion channels. The purpose of this project was to learn how to replicate simple threat detection and response functions within artificial membrane systems. The original goals toward developing 'smart skin' assemblies included: (1) synthesizing functionalized nanoparticles to produce electrochemically responsive systems within a lipid bilayer host matrices, (2) calculating the energetics of nanoparticle-lipid interactions and pore formation, and (3) determining the mechanism of insertion of nanoparticles in lipid bilayers via imaging and electrochemistry. There are a few reports of the use of programmable materials to open and close pores in rigid hosts such as mesoporous materials using either heat or light activation. However, none of these materials can regulate themselves in response to the detection of threats. The strategies we investigated in this project involve learning how to use programmable nanomaterials to automatically eliminate open channels within a lipid bilayer host when 'threats' are detected. We generated and characterized functionalized nanoparticles that can be used to create synthetic pores through the membrane and investigated methods of eliminating the pores either through electrochemistry, change in pH, etc. We also focused on characterizing the behavior of functionalized gold NPs in different lipid membranes and lipid vesicles and coupled these results to modeling efforts designed to gain an understanding of the interaction of nanoparticles within lipid assemblies.

Montano, Gabriel A.; Xiao, Xiaoyin; Achyuthan, Komandoor E.; Allen, Amy; Brozik, Susan Marie; Edwards, Thayne L.; Frischknecht, Amalie Lucile; Wheeler, David Roger

2011-09-01T23:59:59.000Z

118

allergic skin disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the microbiome...The Skin Microbiome in Healthy and Allergic Dogs Aline Rodrigues Hoffmann1*, Adam P. Patterson2, Alison Diesel2, Sara D. Lawhon4, Hoai Jaclyn Ly1, Christine...

119

allergic skin diseases: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the microbiome...The Skin Microbiome in Healthy and Allergic Dogs Aline Rodrigues Hoffmann1*, Adam P. Patterson2, Alison Diesel2, Sara D. Lawhon4, Hoai Jaclyn Ly1, Christine...

120

SLUG TESTING IN WELLS WITH FINITE-THICKNESS SKIN  

SciTech Connect (OSTI)

We present an analysis of the slug test in a well surrounded by an annulus of altered material, which is treated as a skin of finite thickness. By assuming the skin has a thickness, the storage capacity of the altered material is included in the analysis. The problem is solved in the Laplace domain. The solution is found in terms of well-bore storage and the thickness, hydraulic conductivity, and specific storage of the skin. Type curves are generated by numerical inversion of the Laplace transform solution. We find that standard methods of analysis, involving a skin of infinitesimal thickness, are adequate for open-well or drill-stem tests. However, for pressurized tests the response may differ markedly from standard slug-test solutions.

Moench, A.F.; Hsieh

1985-01-22T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Second Skin : motion capture with actuated feedback for motor learning  

E-Print Network [OSTI]

Second Skin aims to combine three-dimensional (3D) motion tracking with tactile feedback for the purpose of improving users' motor-learning ability. Such a system would track a user's body and limb movements as he or she ...

Miaw, Dennis (Dennis R.)

2010-01-01T23:59:59.000Z

122

acute skin reaction: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

from a complex reaction induced by plant pigments exposed to ultraviolet (UV) wave length sunlight in the skin of animals that have eaten certain plants 1-3. This reaction is...

123

attenuate skin dryness: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with ultra-low density and high thermal stability. The supersolidity of skin sliperizes ice. Xi Zhang; Yongli Huang; a Zengsheng Ma; Yichun Zhou; Chang Q Sun 2013-10-03 9 Journal...

124

artificial skin applications: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with ultra-low density and high thermal stability. The supersolidity of skin sliperizes ice. Xi Zhang; Yongli Huang; a Zengsheng Ma; Yichun Zhou; Chang Q Sun 2013-10-03 117 An...

125

Involvement of TGF-beta in skin photoaging  

E-Print Network [OSTI]

The goal of this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major ...

Choi, Won Seon, 1975-

2005-01-01T23:59:59.000Z

126

Nuclear skin emergence in Skyrme deformed Hartree-Fock calculations  

E-Print Network [OSTI]

A study of the charge and matter densities and the corresponding rms radii for even-even isotopes of Ni, Kr, and Sn has been performed in the framework of deformed self-consistent mean field Skyrme HF+BCS method. The resulting charge radii and neutron skin thicknesses of these nuclei are compared with available experimental data, as well as with other theoretical predictions. The formation of a neutron skin, which manifests itself in an excess of neutrons at distances greater than the radius of the proton distribution, is analyzed in terms of various definitions. Formation of a proton skin is shown to be unlikely. The effects of deformation on the neutron skins in even-even deformed nuclei far from the stability line are discussed.

Sarriguren, P; de Guerra, E Moya; Antonov, A N

2007-01-01T23:59:59.000Z

127

Mpemba paradox: Hydrogen bond memory and water-skin supersolidity  

E-Print Network [OSTI]

Numerical reproduction of measurements, experimental evidence for skin super-solidity and hydrogen-bond memory clarified that Mpemba paradox integrates the heat emission-conduction-dissipation dynamics in the source-path-drain cycle system.

Chang Q Sun

2015-01-05T23:59:59.000Z

128

Carmichael's Concise Review Microscopy is Only Skin Deep  

E-Print Network [OSTI]

Carmichael's Concise Review Microscopy is Only Skin Deep Stephen W. Carmichael Mayo Clinic. Coming Events 2011 EMAS 2011 May 15­19, 2011 Angers, France www.emas-web.net IUMAS-V May 22­27, 2011

Heller, Eric

129

Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations  

DOE Patents [OSTI]

Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level in the theater of operation of the irradiation site of the biological tissues before and/or during the cryogenic spray cooling of the biological tissue. At cold temperatures calibration was achieved by mounting a thermistor on a thermoelectric cooler. The thermal electric cooler was cooled from from 20.degree. C. to about -20.degree. C. while measuring its infrared emission.

Nelson, J. Stuart (Laguna Niguel, CA); Anvari, Bahman (Houston, TX); Tanenbaum, B. Samuel (Irvine, CA); Milner, Thomas E. (Austin, TX)

1999-01-01T23:59:59.000Z

130

Fluorescent silica colloids for study and visualization of skin care products  

E-Print Network [OSTI]

due to long exposures to cold and dry air (7). Different skin care products are used to hy- drate dryFluorescent silica colloids for study and visualization of skin care products Swaminathan Iyer: The efficacy of skin care products depends on the time and dynamics of their absorbance by the skin, and its

Sokolov, Igor

131

Intraluminal tissue welding for anastomosis  

DOE Patents [OSTI]

A method and device are provided for performing intraluminal tissue welding for anastomosis of a hollow organ. A retractable catheter assembly is delivered through the hollow organ and consists of a catheter connected to an optical fiber, an inflatable balloon, and a biocompatible patch mounted on the balloon. The disconnected ends of the hollow organ are brought together on the catheter assembly, and upon inflation of the balloon, the free ends are held together on the balloon to form a continuous channel while the patch is deployed against the inner wall of the hollow organ. The ends are joined or ``welded`` using laser radiation transmitted through the optical fiber to the patch. A thin layer of a light-absorbing dye on the patch can provide a target for welding. The patch may also contain a bonding agent to strengthen the bond. The laser radiation delivered has a pulse profile to minimize tissue damage. 8 figs.

Glinsky, M.; London, R.; Zimmerman, G.; Jacques, S.

1998-10-27T23:59:59.000Z

132

Intraluminal tissue welding for anastomosis  

DOE Patents [OSTI]

A method and device are provided for performing intraluminal tissue welding for anastomosis of a hollow organ. A retractable catheter assembly is delivered through the hollow organ and consists of a catheter connected to an optical fiber, an inflatable balloon, and a biocompatible patch mounted on the balloon. The disconnected ends of the hollow organ are brought together on the catheter assembly, and upon inflation of the balloon, the free ends are held together on the balloon to form a continuous channel while the patch is deployed against the inner wall of the hollow organ. The ends are joined or "welded" using laser radiation transmitted through the optical fiber to the patch. A thin layer of a light-absorbing dye on the patch can provide a target for welding. The patch may also contain a bonding agent to strengthen the bond. The laser radiation delivered has a pulse profile to minimize tissue damage.

Glinsky, Michael (Livermore, CA); London, Richard (Orinda, CA); Zimmerman, George (Lafayette, CA); Jacques, Steven (Portland, OR)

1998-10-27T23:59:59.000Z

133

Mechanical formalism for tissue dynamics  

E-Print Network [OSTI]

The understanding of morphogenesis in living organisms has been renewed by tremendous progress in experimental techniques that provide access to cell-scale, quantitative information both on the shapes of cells within tissues and on the genes being expressed. This information suggests that our understanding of the respective contributions of gene expression and mechanics, and of their crucial entanglement, will soon leap forward. Biomechanics increasingly benefits from models, which assist the design and interpretation of experiments, point out the main ingredients and assumptions, and ultimately lead to predictions. The newly accessible local information thus calls for a reflection on how to select suitable classes of mechanical models. We review both mechanical ingredients suggested by the current knowledge of tissue behaviour, and modelling methods that can help generate a rheological diagram or a constitutive equation. We distinguish cell scale ("intra-cell") and tissue scale ("inter-cell") contributions. We recall the mathematical framework developped for continuum materials and explain how to transform a constitutive equation into a set of partial differential equations amenable to numerical resolution. We show that when plastic behaviour is relevant, the dissipation function formalism appears appropriate to generate constitutive equations; its variational nature facilitates numerical implementation, and we discuss adaptations needed in the case of large deformations. The present article gathers theoretical methods that can readily enhance the significance of the data to be extracted from recent or future high throughput biomechanical experiments.

Sham Tlili; Cyprien Gay; Francois Graner; Philippe Marcq; François Molino; Pierre Saramito

2014-12-23T23:59:59.000Z

134

Biomimetic electrical stimulation for cardiac tissue engineering  

E-Print Network [OSTI]

A major challenge of tissue engineering is directing cells to establish the physiological structure and function of the tissue being replaced. Electrical stimulation has been used to induce synchronous contractions of ...

Tandon, Nina

2006-01-01T23:59:59.000Z

135

A Supersolid Skin Covering both Water and Ice  

E-Print Network [OSTI]

The mysterious nature and functionality of water and ice skins remain baffling to the community since 1859 when Farady firstly proposed liquid skin lubricating ice. Here we show the presence of supersolid phase that covers both water and ice using Raman spectroscopy measurements and quantum calculations. In the skin of two molecular layers thick, molecular undercoordination shortens the H-O bond by ~16% and lengthens the OH nonbond by ~25% through repulsion between electron pairs on adjacent O atoms, which depresses the density from 0.92 for bulk ice to 0.75 gcm-3. The O:H-O cooperative relaxation stiffens the H-O stretching phonon from 3200/3150 cm-1 to the same value of 3450 cm-1 and raises the melting temperature of both skins by up to ~310 K. Numerical derivatives on the viscosity and charge accumulation suggests that the elastic, polarized, and thermally stable supersolid phase makes the ice frictionless and water skin hydrophobic and ice like at room temperature.

Sun, Chang Q

2014-01-01T23:59:59.000Z

136

A clamp ligation method for point mutational spectrometry : marked increase in scanning range for the human genome  

E-Print Network [OSTI]

The study of human mutagenesis requires methods of measuring somatic mutations in normal human tissues and inherited mutations in human populations. Such methods should permit measurement of rare mutations in the presence ...

Kim, Andrea Seungsun, 1971-

2002-01-01T23:59:59.000Z

137

Factors Associated with the Decision to Hospitalize Emergency Department Patients with a Skin and Soft Tissue Infection  

E-Print Network [OSTI]

Staphylococcus aureus (MRSA). 2 Hospitalizations for SSTICo-morbidity - n (%) Any Prior MRSA infection Diabetesmagnetic resonance imaging; MRSA, methicillin-resistant S.

2015-01-01T23:59:59.000Z

138

Viability of adult rat skin following 13 Mev proton irradiation  

E-Print Network [OSTI]

then removed from suspension by centrifugation and washed twice in Smith's chick heart growth media. 33 All cells removed from the biopsy by this enzyme dissection were placed in culture to check viability. Two Rose chambers con- taining the first scraping... Dissipation . Diagram ? Proton Energy Dissipation 17 17 Cell Suspension Filter Tube. Exploded View of Rose Chamber 24 Rat 822, Gross Appearance 37 SB. Rat 822, Skin Section. 38 Rat 771, Gross Appearance 37 Rat 771, Skin Section. 38 7A. 7B. Rat 835...

Caraway, Bobby Lamar

1966-01-01T23:59:59.000Z

139

InVERT molding for scalable control of tissue microarchitecture  

E-Print Network [OSTI]

Complex tissues contain multiple cell types that are hierarchically organized within morphologically and functionally distinct compartments. Construction of engineered tissues with optimized tissue architecture has been ...

Ungrin, M. D.

140

Do metallic ports in tissue expanders affect postmastectomy radiation delivery?  

SciTech Connect (OSTI)

Purpose: Postmastectomy radiation therapy (PMRT) is often delivered to patients with permanent breast implants. On occasion, patients are irradiated with a tissue expander (TE) in place before their permanent implant exchange. Because of concern of potential under-dosing in these patients, we examined the dosimetric effects of the Magna-Site (Santa Barbara, CA) metallic port that is present in certain TEs. Methods and Materials: We performed ex vivo film dosimetry with single 6-MV and 15-MV photon beams on a water phantom containing a Magna-Site disc in two orientations. Additionally, using in vivo films, we measured the exit dose from 1 patient's TE-reconstructed breast during chest wall treatment with 15-MV tangent beams. Finally, we placed thermoluminescent dosimeters (TLDs) on 6 patients with TEs who received PMRT delivered with 15-MV tangent beams. Results: Phantom film dosimetry revealed decreased transmission in the region of the Magna-Site, particularly with the magnet in the parallel orientation (at 22 mm: 78% transmission with 6 MV, 84% transmission with 15 MV). The transmission measured by in vivo films during single beam treatment concurred with ex vivo results. TLD data showed acceptable variation in median dose to the skin (86-101% prescription dose). Conclusion: Because of potential dosimetric effects of the Magna-Site, it is preferable to treat PMRT patients with permanent implants. However, it is not unreasonable to treat with a TE because the volume of tissue affected by attenuation from the Magna-Site is small. In this scenario, we recommend using 15 MV photons with compensating bolus.

Damast, Shari [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Beal, Kathryn [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)]. E-mail: bealk@mskcc.org; Ballangrud, Ase [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Losasso, Thomas J. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Cordeiro, Peter G. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Disa, Joseph J. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Hong, Linda [Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY (United States); McCormick, Beryl L. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2006-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Subclonal variation and skin russeting in potato, (Solanum tuberosum L.)  

E-Print Network [OSTI]

of subclonal selection for putative russet skin mutations of 'Century Russet' was conducted in Texas and Colorado to improve the russeting character in 'Century Russet'. RAPD analysis of a segregating F I family derived from a russet x white cross and of three...

Oehlke, Leslie Lashaun

1997-01-01T23:59:59.000Z

142

A Solar Re-Skin at FedEx Field | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

A Solar Re-Skin at FedEx Field A Solar Re-Skin at FedEx Field August 2, 2011 - 10:40am Addthis Ramamoorthy Ramesh Former Director, SunShot Initiative & Solar Energy Technologies...

143

HandWave : design and manufacture of a wearable wireless skin conductance sensor and housing  

E-Print Network [OSTI]

This thesis report details the design and manufacture of HandWave, a wearable wireless Bluetooth skin conductance sensor, and dedicated housing. The HandWave collects Electrodermal Activity (EDA) data by measuring skin ...

Strauss, Marc D

2005-01-01T23:59:59.000Z

144

E-Print Network 3.0 - age gender skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Kings Cross, London. 19 March 2011. 1 A Paper Negotiating with Skin BY YU-CHIEN WU The French... , there are also misgivings in response to her claim that 'skin is a mask of...

145

E-Print Network 3.0 - assessing skin dose Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by adding up all expo- Summary: or other sources. Most food is, in fact, free of dioxins and furans. 12;29 Estimating Skin Exposure Doses... and for children. Skin Exposure...

146

E-Print Network 3.0 - argentine peanut skins Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

are fed. Molasses are often used to enhance palatability. Both peanut skins... and bakery waste can be difficult to feed. Peanut skins are fluffy and nutrient content varies with...

147

Human brain cancer studied by resonance Raman spectroscopy  

E-Print Network [OSTI]

Human brain cancer studied by resonance Raman spectroscopy Yan Zhou Cheng-Hui Liu Yi Sun Yang Pu://biomedicaloptics.spiedigitallibrary.org/ on 11/16/2012 Terms of Use: http://spiedl.org/terms #12;Human brain cancer studied by resonance Raman of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro

Sun, Yi

148

Tumor Engineering: The Other Face of Tissue Engineering  

SciTech Connect (OSTI)

Advances in tissue engineering have been accomplished for years by employing biomimetic strategies to provide cells with aspects of their original microenvironment necessary to reconstitute a unit of both form and function for a given tissue.We believe that the most critical hallmark of cancer is loss of integration of architecture and function; thus, it stands to reason that similar strategies could be employed to understand tumor biology. In this commentary, we discuss work contributed by Fischbach-Teschl and colleagues to this special issue of Tissue Engineering in the context of 'tumor engineering', that is, the construction of complex cell culture models that recapitulate aspects of the in vivo tumor microenvironment to study the dynamics of tumor development, progression, and therapy on multiple scales. We provide examples of fundamental questions that could be answered by developing such models, and encourage the continued collaboration between physical scientists and life scientists not only for regenerative purposes, but also to unravel the complexity that is the tumor microenvironment. In 1993, Vacanti and Langer cast a spotlight on the growing gap between patients in need of organ transplants and the amount of available donor organs; they reaffirmed that tissue engineering could eventually address this problem by 'applying principles of engineering and the life sciences toward the development of biological substitutes. Mortality figures and direct health care costs for cancer patients rival those of patients who experience organ failure. Cancer is the second leading cause of death in the United States (Source: American Cancer Society) and it is estimated that direct medical costs for cancer patients approach $100B yearly in the United States alone (Source: National Cancer Institute). In addition, any promising therapy that emerges from the laboratory costs roughly $1.7B to take from bench to bedside. Whereas we have indeed waged war on cancer, the training grounds have largely consisted of small rodents, despite marked differences between human and mouse physiology, or plastic dishes, even though just like our tissues and organs most tumors exist within three-dimensional proteinacious milieus. One could argue that this is comparable to training for a desert war in the arctic. In this special issue of tissue engineering, Fischbach-Teschl and colleagues build a strong case for engineering complex cultures analogous to normal organs to tractably model aspects of the human tumor microenvironment that simply cannot be reproduced with traditional two-dimensional cell culture techniques and that cannot be studied in a controlled fashion in vivo. This idea has gained considerable traction of late as concepts presented and convincingly shown years ago have only now begun to be appreciated. Perhaps, then, it is time to organize those who wish to build complex tumor models to study cancer biology under a common umbrella. Accordingly, we propose that tumor engineering be defined as the construction of complex culture models that recapitulate aspects of the in vivo tumor microenvironment to study the dynamics of tumor development, progression, and therapy on multiple scales. Inherent in this definition is the collaboration that must occur between physical and life scientists to guide the design of patterning techniques, materials, and imaging modalities for the study of cancer from the subcellular to tissue level in physiologically relevant contexts. To date, the most successful tissue engineering approaches have employed methods that recapitulate the composition, architecture, and/or chemical presentation of native tissue. For instance, induction of blood vessel growth for therapeutic purposes has been achieved with sequential release of vascular endothelial growth factor (VEGF) and platelet derived growth factor to induce and stabilize blood vessels. This approach imitates that which occurs during physiological angiogenesis as a result of heterotypic interactions between endothelium and stroma. Employing such biomimetic

Ghajar, Cyrus M; Bissell, Mina J

2010-03-09T23:59:59.000Z

149

Skin tone of targets, lineup type, and confidence levels in cross-racial identification  

E-Print Network [OSTI]

The current experiment investigated facial recognition memory for own and other-race faces. Two variations (light-skin and dark-skin) were presented for the Black targets. The purpose of this experiment was to observe the effect of skin variations...

Williamson, Jessica Lynne

2013-02-22T23:59:59.000Z

150

Skin cancer is the most com-mon form of cancer in the United  

E-Print Network [OSTI]

Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

151

Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)  

E-Print Network [OSTI]

Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

Massachusetts at Amherst, University of

152

The Effect of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin  

E-Print Network [OSTI]

The Effect of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin preserved as it travels across the skin. Our results suggest, then, that the propagation of surface waves of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin. PLoS ONE 7(2): e31203

Elias, Damian Octavio

153

Tissue Imaging Using Nanospray Desorption Electrospray Ionization...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

drug discovery, molecular biology, and biochemistry. Citation: Laskin J, BS Heath, PJ Roach, LH Cazares, and OJ Semmes.2012."Tissue Imaging Using Nanospray Desorption...

154

E-Print Network 3.0 - adult human livers Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human cartilage... and cirrhotic human liver. Connect Tissue Res 1989;23:19-31. 37 Nord HJ. Biopsy diagnosis of cirrhosis: blind... Serum levels of YKL-40 and PIIINP as...

155

Heart valve tissue engineering Frank Baaijens  

E-Print Network [OSTI]

Heart valve tissue engineering Frank Baaijens Department of Biomedical Engineering Eindhoven University of Technology Netherlands Tissue engineered heart valves appear promising as autologous valvular functionality and durability of the heart valve relies on the strength and anisotropic properties of the valve

Stavroulakis, Georgios E.

156

TFE 2014-2015 Computational Tissue Engineering  

E-Print Network [OSTI]

CellsCarriers Culture Tissue Engineering 1924/04/2014 All rights reserved © 2014 #12;Patient CellsCarriers Culture Tissue Engineering 2024/04/2014 All rights reserved © 2014 #12;Gene network modeling 2124/04/2014 All rights reserved © 2014 Complexity Mechanisticmodelling Phenomenologicalmodelling Scope Data

Wolper, Pierre

157

Lithium Ion Battery Performance of Silicon Nanowires With Carbon Skin  

SciTech Connect (OSTI)

Silicon (Si) nanomaterials have emerged as a leading candidate for next generation lithium-ion battery anodes. However, the low electrical conductivity of Si requires the use of conductive additives in the anode film. Here we report a solution-based synthesis of Si nanowires with a conductive carbon skin. Without any conductive additive, the Si nanowire electrodes exhibited capacities of over 2000 mA h g-1 for 100 cycles when cycled at C/10 and over 1200 mA h g-1 when cycled more rapidly at 1C against Li metal.. In situ transmission electron microscopy (TEM) observation reveals that the carbon skin performs dual roles: it speeds lithiation of the Si nanowires significantly, while also constraining the final volume expansion. The present work sheds light on ways to optimize lithium battery performance by smartly tailoring the nanostructure of composition of materials based on silicon and carbon.

Bogart, Timothy D.; Oka, Daichi; Lu, Xiaotang; Gu, Meng; Wang, Chong M.; Korgel, Brian A.

2013-12-06T23:59:59.000Z

158

Anomalous skin effects in a weakly magnetized degenerate electron plasma  

SciTech Connect (OSTI)

Fully relativistic analysis of anomalous skin effects for parallel propagating waves in a weakly magnetized degenerate electron plasma is presented and a graphical comparison is made with the results obtained using relativistic Maxwellian distribution function [G. Abbas, M. F. Bashir, and G. Murtaza, Phys. Plasmas 18, 102115 (2011)]. It is found that the penetration depth for R- and L-waves for degenerate case is qualitatively small in comparison with the Maxwellian plasma case. The quantitative reduction due to weak magnetic field in the skin depth in R-wave for degenerate plasma is large as compared to the non-degenerate one. By ignoring the ambient magnetic field, previous results for degenerate field free case are salvaged [A. F. Alexandrov, A. S. Bogdankevich, and A. A. Rukhadze, Principles of Plasma Electrodynamics (Springer-Verlag, Berlin/Heidelberg, 1984), p. 90].

Abbas, G., E-mail: gohar.abbas@gcu.edu.pk; Sarfraz, M. [Department of Physics, GC University Lahore, Katchery Road, Lahore 54000 (Pakistan); Shah, H. A. [Forman Christian College University, Farozpur Road, Lahore 54600 (Pakistan)

2014-09-15T23:59:59.000Z

159

The adipose tissue to serum dichlorodiphenyldichloroethane (DDE) ratio: Some methodological considerations  

SciTech Connect (OSTI)

Dichlorodiphenyldichloroethane (DDE) adipose tissue level has been regarded as a preferred indicator of accumulated human exposure to DDT; however, blood sera are more feasible to obtain and analyze than adipose tissue samples. Inconsistent and scarce information exists in relation to the adipose tissue/serum DDE ratio. As a part of a hospital-based case-control study performed in Mexico City from 1994 to 1996, 198 paired serum and adipose tissue samples were obtained from 72 women with histologically confirmed breast cancer and 126 women with benign breast disease. Both adipose tissue and serum DDE levels were determined by gas-liquid chromatography and reported as ppb lipid weight (ng/g) as well as wet basis (ng/ml). Results showed that the adipose tissue/serum DDE ratio (ADSE) varies according to the type of information (lipid vs wet basis, arithmetic vs geometric means) used for its estimation. ADSE gets a value near 1 (1.1) only when the geometric DDE levels in lipid basis are used for its estimation. The correlation between DDE serum and adipose tissue levels was found (r = 0.364, P < 0.001). The ADSE did not vary by disease status, nor was it altered by parity, history of breast-feeding, and other reproductive characteristics. The authors endorse the use of venipuncture instead of biopsy as a way to estimate DDT body burden levels in further research.

Lopez-Carrillo, L. (Mexico Secretariat of Health, Cuernavaca (Mexico). National Inst. of Public Health John D. and Catherine T. MacArthur Foundation (United States)); Torres-Sanchez, L.; Lopez-Cervantes, M. (Mexico Secretariat of Health, Cuernavaca (Mexico). National Inst. of Public Health); Blair, A. (National Cancer Inst., Bethesda, MD (United States)); Cebrian, M.E.; Uribe, M. (National Polytechnic Inst. (United States). Center for Research and Advanced Studies)

1999-08-01T23:59:59.000Z

160

Skin effect with arbitrary specularity in Maxwellian plasma  

E-Print Network [OSTI]

The problem of skin effect with arbitrary specularity in maxwellian plasma with specular--diffuse boundary conditions is solved. A new analytical method is developed that makes it possible to to obtain a solution up to an arbitrary degree of accuracy. The method is based on the idea of symmetric continuation not only the electric field, but also electron distribution function. The solution is obtained in a form of von Neumann series.

Anatoly V. Latyshev; Alexander A. Yushkanov

2009-12-10T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Chemical Agent Induced Reduction of Skin Light Scattering  

E-Print Network [OSTI]

scattering with the potential to increase the efficacy of light based imaging and therapeutic applications. Three hypotheses have been suggested for the clearing mechanism: index of refraction matching between clearing agent and collagen, tissue dehydration...

Hirshburg, Jason M.

2011-02-22T23:59:59.000Z

162

The Production and Analysis of Biodiesel from Waste Chicken Skin and Pork Skin Fat and a Comparison of Fuel Properties to Petroleum Derived Diesel Fuel  

E-Print Network [OSTI]

Abstract—People today are increasingly health conscious and therefore shopkeepers tend to dispose of fatty chicken and pork skin. Chicken and pork skins thus are sources of solid waste that are usually not utilized. This paper deals with the production of useful biodiesel from utilizing the waste chicken and pork skins. Fat from the waste chicken and pork skins (sourced from local shops), was first extracted and subjected to transesterification. The products of transesterification were FAME (Fatty acid methyl esters) and glycerol. The FAME produced was tested for five parameters namely calorific value, pour point and cloud point when compared to ASTM E2515-11 standard values. Comparison of the obtained values of the five parameters with the standard values for diesel was performed to determine the viability of the biodiesel produced. The results of this experiment showed that the calorific values of FAME produced from chicken skin and pork skin fat were close to that of petroleum derived diesel. However, two test parameters namely kinematic viscosity and pour point differed when compared to diesel; this problem can be circumvented by modifying an automobile’s internal combustion engine. Due to the relatively high yield value of biodiesel, it is feasible to utilize chicken skin and pork skin fat at a rural level to produce FAME that can be an alternative to diesel in this time of acute fuel scarcity.

Krish T Bharat; Agni Bhattacharya

163

Gelatin based on Power-gel.TM. as solders for Cr4+laser tissue welding and sealing of lung air leak and fistulas in organs  

DOE Patents [OSTI]

Laser tissue welding can be achieved using tunable Cr4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.

Alfano, Robert R.; Tang, Jing; Evans, Jonathan M.; Ho, Peng Pei

2006-04-25T23:59:59.000Z

164

THERMAL INTERACTION OF CRYOGEN SPRAY WITH HUMAN SKIN UNDER VACUUM PRESSURES  

E-Print Network [OSTI]

During the treatment of port wine stain (PWS) birthmarks laser energy is irradiated at appropriate Riverside, Riverside, CA, 92521, USA. gaguilar@engr.ucr.edu Abstract. Clinical results of port wine stain of this procedure is that laser energy is also absorbed by epidermal melanin, causing localized heating therein

Aguilar, Guillermo

165

Production of immunoglobulins in gingival tissue explant cultures from juvenile periodontitis patients  

SciTech Connect (OSTI)

B lymphocytes and plasma cells are histologically observed in granulomatous periodontal tissues of juvenile periodontitis (JP) patients. Local immune processes may participate in protective or immunopathologic roles in the pathogenesis of this disease. An in vitro explant culture system was utilized to demonstrate the production of immunoglobulins by diseased JP tissues. Immunodiffusion studies using goat anti-human gamma, alpha, or mu chain serum revealed IgG to be the major immunoglobulin present in 92% of the day 1 supernatant fluids (SF) of the 47 JP gingival tissue explant cultures. IgA was present in 15% of the SF; however, no IgM was detected. Staph Protein A isolated 14C-labeled IgG from the SF, when allowed to react with goat anti-human gamma chain serum, formed lines of precipitation. Positive autoradiographs confirmed the biosynthesis of IgG by the explant cultures. The in vitro gingival tissue explant culture system described provides a useful model for the study of localized immunoglobulins produced by diseased tissues of JP patients.

Hall, E.R.; Falkler, W.A. Jr.; Suzuki, J.B. (Univ. of Maryland Dental School, Baltimore (USA))

1990-10-01T23:59:59.000Z

166

Tissue oxymetry using magnetic resonance spectroscopy  

E-Print Network [OSTI]

A noninvasive method for in vivo measurement of tissue oxygen concentration has been developed. Several techniques currently used suffer limitations that prevent their practical clinical use. Our method is to use the ...

Liu, Lisa Chiawen

2005-01-01T23:59:59.000Z

167

augment tissue perfusion: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is...

168

Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering  

E-Print Network [OSTI]

Tissue engineering holds great promise for regeneration and repair of diseased tissues, making the development of tissue engineering scaffolds a topic of great interest in biomedical research. Because of their biocompatibility ...

Annabi, Nasim

169

Mechanical behavior of tissue simulants and soft tissues under extreme loading conditions  

E-Print Network [OSTI]

Recent developments in computer-integrated surgery and in tissue-engineered constructs necessitate advances in experimental and analytical techniques in characterizing properties of mechanically compliant materials such ...

Kalcioglu, Zeynep Ilke

2013-01-01T23:59:59.000Z

170

Iron is the Key to Preserving Dinosaur Soft Tissue  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

grasp. The Evolution of Understanding Previous research findings that identified proteins in dinosaur soft tissue seemed to confirm that the tissue was indeed fossilized...

171

Tumor Engineering: The Other Face of Tissue Engineering  

E-Print Network [OSTI]

Vacanti, J.P. Tissue engineering. Science 260, 920, 1993. 2.dynamic reciprocity: engineering three-dimensional cultureRonnov-Jessen, L. TUMOR ENGINEERING: OTHER FACE OF TISSUE

Ghajar, Cyrus M

2010-01-01T23:59:59.000Z

172

E-Print Network 3.0 - arsenic-related skin lesions Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

7 | July 2002 729 Family Correlations of Arsenic Methylation Patterns in Children and Parents Summary: various health effects, including can- cers of the bladder, skin, and...

173

Management of Pediatric Skin Abscesses in Pediatric, General Academic and Community Emergency Departments  

E-Print Network [OSTI]

Staphylococcus aureus (CA-MRSA) in skin abscesses presentingmeeting on management of MRSA in Conflicts of Interest: Byfor clinical management of MRSA in the community: Summary of

2011-01-01T23:59:59.000Z

174

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection  

E-Print Network [OSTI]

3 vaccine efficacy in MRSA skin versus invasive infectionFig. 1) and suppression of MRSA proliferation (Fig. 2). Eachseverity and suppression of MRSA bioluminescence (Figs. 1

2014-01-01T23:59:59.000Z

175

E-Print Network 3.0 - arsenic skin lesions Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

who had a substantially increased risk of stillbirth... concentrations greater than 400 lgliter and also showed signs of arsenic-caused skin lesions were se- lected......

176

Radiation port dermatophytosis: Tinea corporis occurring at the site of irradiated skin  

E-Print Network [OSTI]

M, Huang J, Arous E: Radiation therapy toxicity to the skin.Radiation port dermatophytosis: Tinea corporis occurring atHouston, Texas Abstract Radiation port dermatophytosis is

Casamiquela, Kathleen M; Cohen, Philip R

2012-01-01T23:59:59.000Z

177

E-Print Network 3.0 - amphibian skin exposed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 6 Global biodiversity loss and the emergence of infec-tious diseases are two of the most pressing environ- Summary: ). Amphibians have permeable skin,...

178

E-Print Network 3.0 - acute skin toxicity Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: that bind to transthyretin, a thyroxine binding protein. 12;Toxicity of Dioxins Acute Toxicity Varies... skin Reproductive effects of not seen with glycols...

179

E-Print Network 3.0 - amphibian skin epithelium Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ulcers & bloating are keySkin... AmphibiansInfections in Wild Amphibians D. Earl Green, DVMD. Earl Green, DVM Department of Interior... % of larvae -- Onset is sudden...

180

E-Print Network 3.0 - artificial skin construct Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and applications, computer vision, adult-content detection, skin color detection Abstract: As more... a tremendous amount of manual work to construct (either directly, or...

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Predicted Solution Structure of Zymogen Human Coagulation FVII  

E-Print Network [OSTI]

for the complete tissue factor-free calcium ion-bound human zymogen FVII (residues 1­406) (FVII) has been-ray crystallographic structure of human coagulation FVIIa/TF complex bound with calcium ions (Banner et al., Nature of interactions regulated by positive and negative feedback loops. In the "initiation stage" in the extrinsic

Perera, Lalith

182

Zo Rebecca Hunter Plasticity of the adult human brain  

E-Print Network [OSTI]

Zoë Rebecca Hunter Plasticity of the adult human brain and motor recovery after stroke PICS © Institute of Cognitive Science #12;1 Bachelor's Thesis Plasticity of the adult human brain and motor brain and motor recovery after stroke 2 Abstract Stroke may cause a major destruction of brain tissue

Kallenrode, May-Britt

183

Distribution of phospholipase C isozymes in various rat tissues and cultured cells  

SciTech Connect (OSTI)

Monoclonal antibodies prepared against PLC-I or PLC-II enzyme did not cross-react with the other. Using a pair of antibodies which recognizes 2 different antigenic sites on the same molecule, radioimmunoassays were developed for the quantitation of PLC-I and PLC-II in homogenates of various tissues and cultured cells, prepared by homogenization in a 2 M KCl buffer. The contents of PLC enzymes were measured in 19 rat tissues, in human platelets and in 17 cultured cells. Results indicate that the concentration of PLC-I and PLC-II is very high in brain, PLC-I is localized mainly in brain and partly in seminal vesicles, PLC-II is found in most tissues and cells. PLC-I is highly localized even in brain: 5 different neuroblastoma did not contain PLC-I while 2 glioma and 1 astrocytoma contained significant amounts.

Suh, P.G.; Ryu, S.H.; Choi, W.C.; Lee, K.Y.; Rhee, S.G.

1987-05-01T23:59:59.000Z

184

The oncogenic action of ionizing radiation on rat skin  

SciTech Connect (OSTI)

The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of [sup 14]C-thymidine. The return of these cells to S-phase a second time was detected by a second label ([sup 3]H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The [sup 14]C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with [sup 14]C increased after 42 hr and remained relatively constant thereafter.

Burns, F.J.; Garte, S.J.

1992-01-01T23:59:59.000Z

185

THE EFFECTS OF HIV INFECTION ON THE EXPRESSION OF THE DRUG EFFLUX PROTEINS P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN IN A HUMAN INTESTINE MODEL  

E-Print Network [OSTI]

Background: Emerging evidence suggests poor antiretroviral penetration within human gastrointestinal (GI) tissues may contribute to HIV persistence within reservoirs despite effective therapy. We hypothesize that HIV ...

Ellis, Kelstan Lynch

2012-08-31T23:59:59.000Z

186

Recently, doctors in Texas have been seeing an increasing number of patients with skin  

E-Print Network [OSTI]

that kill bacteria), also called methicillin-resistant Staphylococcus aureus-- "MRSA." The Texas Department this is happening and how to prevent antibiotic (drug) resistant Staph/MRSA skin infections from spreading. What is a Staph/MRSA skin infection? It can be a pimple, rash, boil, or an open wound. Staph/MRSA is often

187

HEAT TRANSFERS IN A DOUBLE SKIN ROOF VENTILATED BY NATURAL CONVECTION IN SUMMER TIME  

E-Print Network [OSTI]

1 HEAT TRANSFERS IN A DOUBLE SKIN ROOF VENTILATED BY NATURAL CONVECTION IN SUMMER TIME P. H or in tropical and arid countries. In this work, radiation, convection and conduction heat transfers-dimensional numerical simulation of the heat transfers through the double skin reveals the most important parameters

Boyer, Edmond

188

Density dependence of the symmetry energy from neutron skin thickness in finite nuclei  

SciTech Connect (OSTI)

The density dependence of the symmetry energy, characterized by the parameter L, is studied using information provided by the neutron skin thickness in finite nuclei. An estimate of L is obtained from experimental data of antiprotonic atoms. We also discuss the ability of parity violating electron scatering to obtain information about the neutron skin thickness in {sup 208}Pb.

Vinas, X.; Centelles, M.; Roca-Maza, X.; Warda, M. [Departament d'Estructura i Conastituents de la Materia and Institut de Ciencies del Cosmos, Facultat de Fisica, Universitat de Barcelona, Marti i Franques 1, 08028, Barcelona (Spain); Instituto Nazionale di Fisica Nucleare, Sezione di Milano , Via Celoria 16, I-20133 Milano (Italy); Katedra Fizyki Teoretycznej, Uniwersytet Marii Curie-Skodowskiej ul. Radziszewskiego 10, 20-031 Lublin (Poland)

2012-10-20T23:59:59.000Z

189

Automatic Skin Enhancement with Visible and Near-Infrared Image Fusion  

E-Print Network [OSTI]

Automatic Skin Enhancement with Visible and Near-Infrared Image Fusion Sabine SĂĽsstrunk School and hemo- globin, the key components of skin color, have little absorp- tion in the near-infrared (NIR to the incident light's wavelength, we show that near-infrared images provide information that can be used

Salvaggio, Carl

190

Towards a Minimal Architecture for a Printable, Modular, and Robust Sensing Skin  

E-Print Network [OSTI]

. Bachrach, and R.S. Fearing Abstract-- This work presents a low-complexity modular sensor grid architecture to provide a smart skin to non-convex shapes, such as a robot body and legs. To configure a sensing skin shaped by arbitrary cuts and rapid changes in designs, we use a wavefront planning approach to generate

Fearing, Ron

191

Associations Between Drinking Water and Urinary Arsenic Levels and Skin Lesions in  

E-Print Network [OSTI]

Associations Between Drinking Water and Urinary Arsenic Levels and Skin Lesions in Bangladesh Graziano, PhD The present study examined the associations between drinking water and urinary arsenic levels currently drinking water containing concentrations of arsenic 50 g/L. The risk for skin lesions in relation

van Geen, Alexander

192

Arsenic in Drinking Water and Skin Lesions: Dose-Response Data from West Bengal, India  

E-Print Network [OSTI]

Arsenic in Drinking Water and Skin Lesions: Dose-Response Data from West Bengal, India Reina Haque the dose-re- sponse relation between low arsenic concentrations in drinking water and arsenic-induced skin peak arsenic concentration in drinking water was 325 g/liter for cases and 180 g/liter for controls

California at Berkeley, University of

193

Modelling and simulation of skin-stretch-caused motion artefacts in single-channel ECG signal  

E-Print Network [OSTI]

Modelling and simulation of skin-stretch-caused motion artefacts in single-channel ECG signal in better understanding of artefacts in ECG and in developing model-based techniques for cleaning or interpreting noisy ECG signals. This work com- bines existing experimental results from the field of skin

Hamburg,.Universität

194

Forensic identification using skin bacterial communities Noah Fierera,b,1  

E-Print Network [OSTI]

Forensic identification using skin bacterial communities Noah Fierera,b,1 , Christian L. Lauberb are personalized, we hypothesized that we could use the residual skin bacteria left on objects for forensic approach, this series ofstudies introducesa forensics approach that could eventually be used

Fierer, Noah

195

Human Ecology Human ecology Research  

E-Print Network [OSTI]

Channel, Latin America. STUDIOS Architecture. #12;HUMAN ECOLOGY · APRIL 2005 1 Lisa Staiano-Coico, Ph Frey spins a green alternative for textiles. Fibers from rapidly renewable materials

Wang, Z. Jane

196

Deep Beams and Slabs The purpose of skin reinforcement in a deep beam is to limit the  

E-Print Network [OSTI]

Deep Beams and Slabs Deep Beams The purpose of skin reinforcement in a deep beam is to limit require different amounts of skin reinforcement. The purpose of our experiment is to compare beams designed with the different amounts of skin reinforcement required by these codes. 3 deep beams following

Barthelat, Francois

197

Combining visible and near-infrared images for realistic skin Clement Fredembach, Nathalie Barbuscia and Sabine Susstrunk  

E-Print Network [OSTI]

Combining visible and near-infrared images for realistic skin smoothing Cl´ement Fredembach components of skin colour, have little absorption in the near-infrared part of the spectrum propose that near-infrared images provide information that can be used to automatically smooth skin tones

Salvaggio, Carl

198

Mechanical properties of collagen-based scaffolds for tissue regeneration  

E-Print Network [OSTI]

Collagen-glycosaminoglycan (CG) scaffolds for the regeneration of skin and nerve have previously been fabricated by freeze-drying a slurry containing a co-precipitate of collagen and glycosaminoglycan. Recently, mineralized ...

Kanungo, Biraja Prasad, 1980-

2009-01-01T23:59:59.000Z

199

Method and apparatus for determining fat content of tissue  

DOE Patents [OSTI]

A method and apparatus for determining characteristics of tissue is disclosed. The method comprises supplying optical energy to a tissue and detecting at a plurality of locations consequent energy scattered by the tissue. Analysis of the scattered energy as taught herein provides information concerning the properties of the tissue, specifically information related to the fat and lean content and thickness of the tissue. The apparatus comprises a light source adapted to deliver optical energy to a tissue. A plurality of detectors can be mounted at different positions relative to the source to detect energy scattered by the tissue. A signal processor as taught herein can determine characteristics of the tissue from the signals from the detectors and locations of the detectors, specifically information related to the fat and lean content and thickness of the tissue.

Weber, Thomas M. (Albuquerque, NM); Spletzer, Barry L. (Albuquerque, NM); Bryan, Jon R. (Edgewood, NM); Dickey, Fred M. (Albuquerque, NM); Shagam, Richard N. (Albuquerque, NM); Gooris, Luc (Rancho Santa Margarita, CA)

2001-01-01T23:59:59.000Z

200

ATHENA, the Desktop Human "Body"  

SciTech Connect (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2014-09-29T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

ATHENA, the Desktop Human "Body"  

ScienceCinema (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2015-01-05T23:59:59.000Z

202

Genetic Background Modulates Gene Expression Profile Induced by Skin Irradiation in Ptch1 Mice  

SciTech Connect (OSTI)

Purpose: Ptch1 germ-line mutations in mice predispose to radiation-induced basal cell carcinoma of the skin, with tumor incidence modulated by the genetic background. Here, we examined the possible mechanisms underlying skin response to radiation in F1 progeny of Ptch1{sup neo67/+} mice crossed with either skin tumor-susceptible (Car-S) or -resistant (Car-R) mice and X-irradiated (3 Gy) at 2 days of age or left untreated. Methods and Materials: We conducted a gene expression profile analysis in mRNA samples extracted from the skin of irradiated or control mice, using Affymetrix whole mouse genome expression array. Confirmation of the results was done using real-time reverse-transcriptase polymerase chain reaction. Results: Analysis of the gene expression profile of normal skin of F1 mice at 4 weeks of age revealed a similar basal profile in the nonirradiated mice, but alterations in levels of 71 transcripts in irradiated Ptch1{sup neo67/+} mice of the Car-R cross and modulation of only eight genes in irradiated Ptch1{sup neo67/+} mice of the Car-S cross. Conclusions: These results indicate that neonatal irradiation causes a persistent change in the gene expression profile of the skin. The tendency of mice genetically resistant to skin tumorigenesis to show a more complex pattern of transcriptional response to radiation than do genetically susceptible mice suggests a role for this response in genetic resistance to basal cell tumorigenesis.

Galvan, Antonella; Noci, Sara [Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy); Mancuso, Mariateresa; Pazzaglia, Simonetta; Saran, Anna [ENEA Laboratories, Rome (Italy); Dragani, Tommaso A. [Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy)], E-mail: tommaso.dragani@istitutotumori.mi.it

2008-12-01T23:59:59.000Z

203

Precursors to radiopharmaceutical agents for tissue imaging  

DOE Patents [OSTI]

A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

Srivastava, Prem C. (Oak Ridge, TN); Knapp, Jr., Furn F. (Oak Ridge, TN)

1988-01-01T23:59:59.000Z

204

The second skin approach : skin strain field analysis and mechanical counter pressure prototyping for advanced spacesuit design  

E-Print Network [OSTI]

The primary aim of this thesis is to advance the theory of advanced locomotion mechanical counter pressure (MCP) spacesuits by studying the changes in the human body shape during joint motion. Two experiments take advantage ...

Bethke, Kristen (Kristen Ann)

2005-01-01T23:59:59.000Z

205

p27{sup Kip1} inhibits tissue factor expression  

SciTech Connect (OSTI)

Highlights: •p27{sup Kip1}regulates the expression of tissue factor at the transcriptional level. •This inhibitory effect of p27{sup Kip1} is independently of its cell regulatory action. •The current study provides new insights into a pleiotrophic function of p27{sup Kip1}. -- Abstract: Background: The cyclin-dependent kinase inhibitor (CDKI) p27{sup Kip1} regulates cell proliferation and thus inhibits atherosclerosis and vascular remodeling. Expression of tissue factor (TF), the key initator of the coagulation cascade, is associated with atherosclerosis. Yet, it has not been studied whether p27{sup Kip1} influences the expression of TF. Methods and results: p27{sup Kip1} overexpression in human aortic endothelial cells was achieved by adenoviral transfection. Cells were rendered quiescent for 24 h in 0.5% fetal-calf serum. After stimulation with TNF-? (5 ng/ml), TF protein expression and activity was significantly reduced (n = 4; P < 0.001) in cells transfected with p27{sup Kip1}. In line with this, p27{sup Kip1} overexpression reduced cytokine-induced TF mRNA expression (n = 4; P < 0.01) and TF promotor activity (n = 4; P < 0.05). In contrast, activation of the MAP kinases p38, ERK and JNK was not affected by p27{sup Kip1} overexpression. Conclusion: This in vitro study suggests that p27{sup Kip1} inhibits TF expression at the transcriptional level. These data indicate an interaction between p27{sup Kip1} and TF in important pathological alterations such as atherosclerosis and vascular remodeling.

Breitenstein, Alexander, E-mail: alexander.breitenstein@usz.ch [Cardiology, University Heart Center, University Hospital Zurich (Switzerland) [Cardiology, University Heart Center, University Hospital Zurich (Switzerland); Cardiovascular Research, Physiology Institute, University of Zurich (Switzerland); Center for Integrative Human Physiology (ZHIP), University of Zurich (Switzerland); Akhmedov, Alexander; Camici, Giovanni G.; Lüscher, Thomas F.; Tanner, Felix C. [Cardiology, University Heart Center, University Hospital Zurich (Switzerland) [Cardiology, University Heart Center, University Hospital Zurich (Switzerland); Cardiovascular Research, Physiology Institute, University of Zurich (Switzerland); Center for Integrative Human Physiology (ZHIP), University of Zurich (Switzerland)

2013-10-04T23:59:59.000Z

206

A common supersolid low-density skin sliperizing ice and toughening water surface  

E-Print Network [OSTI]

Skins of water and ice share the same attribute of supersolidity characterized by the identical H-O vibration frequency of 3450 cm-1. Molecular undercoordination and inter-electron-pair repulsion shortens the H-O bond and lengthen the O:H nonbond, leading to a dual process of nonbonding electron polarization. This relaxation-polarization process enhances the dipole moment, elasticity,viscosity, thermal stability of these skins with 25% density loss, which is responsible for the hydrophobicity and toughness of water skin and for the slippery of ice.

Xi Zhang; Yongli Huang; Zengsheng Ma; Yichun Zhou; Weitao Zheng; Ji Zhou; Chang Q. Sun

2014-08-15T23:59:59.000Z

207

Sensitivity of the electric dipole polarizability to the neutron skin thickness in {sup 208}Pb  

SciTech Connect (OSTI)

The static dipole polarizability, {alpha}{sub D}, in {sup 208}Pb has been recently measured with highresolution via proton inelastic scattering at the Research Center for Nuclear Physics (RCNP) [1]. This observable is thought to be intimately connected with the neutron skin thickness, r{sub skin}, of the same nucleus and, more fundamentally, it is believed to be associated with the density dependence of the nuclear symmetry energy. The impact of r{sub skin} on {alpha}{sub D} in {sup 208}Pb is investigated and discussed on the basis of a large and representative set of relativistic and non-relativistic nuclear energy density functionals (EDF) [2].

Roca-Maza, X.; Agrawal, B. K.; Colo, G.; Nazarewicz, W.; Paar, N.; Piekarewicz, J.; Reinhard, P.-G.; Vretenar, D. [INFN, sezione di Milano, via Celoria 16, I-20133 Milano (Italy); Saha Institute of Nuclear Physics, Kolkata 700064 (India); Dipartimento di Fisica, Universita degli Studi di Milano and INFN, Sezione di Milano, 20133 Milano (Italy); Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996 (United States) and Institute of Theoretical Physics, University of Warsaw, Hoza 69, PL-00-681 Warsaw (Poland); Physics Department, Faculty of Science, University of Zagreb, Zagreb (Croatia); Department of Physics, Florida State University, Tallahassee, FL 32306 (United States); Institut fuer Theoretische Physik II, Universitaet Erlangen-Nuernberg, Staudtstrasse 7, D-91058 Erlangen (Germany); Physics Department, Faculty of Science, University of Zagreb, Zagreb (Croatia)

2012-10-20T23:59:59.000Z

208

A tissue engineering strategy for integrative cartilage repair  

E-Print Network [OSTI]

Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue ...

Mroszczyk, Keri A

2014-01-01T23:59:59.000Z

209

Optical Mapping of Impulse Propagation in Engineered Cardiac Tissue  

E-Print Network [OSTI]

Cardiac tissue engineering has a potential to provide functional, synchronously contractile tissue constructs for heart repair, and for studies of development and disease using in vivo–like yet controllable in vitro settings. ...

Radisic, Milica

210

HOXB1 Founder Mutation in Humans Recapitulates the Phenotype of Hoxb1[superscript ?/?] Mice  

E-Print Network [OSTI]

Members of the highly conserved homeobox (HOX) gene family encode transcription factors that confer cellular and tissue identities along the antero-posterior axis of mice and humans. We have identified a founder homozygous ...

Webb, Bryn D.

211

E-Print Network 3.0 - allergic skin inflammation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tetrakis(dimethylamino)hafnium P-6280-B Date: February 2005 Copyright 2002, 2004-2005, Praxair Technology, Inc. Page 1 of 8 Summary: dermatitis (inflammation of the skin). With...

212

Is the duration of skin disease visits decreasing in the united states?  

E-Print Network [OSTI]

on fridays. J Dermatolog Treat 2013 Dec;24(6):405-7. [PMID:treatment. J Dermatolog Treat 2014 Dec;25(6):453-8. [PMID:Although non-dermatologists treat about half of all skin

Davis, Scott A; Feldman, Steven R; Fleischer Jr., Alan B

2015-01-01T23:59:59.000Z

213

FATIGUE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES  

E-Print Network [OSTI]

FATIGUE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES by Robert B in the Instron and Composite Laboratories toward the end of the experimental research. Finally, special thanks

214

Meeting report for the 1st skin microbiota workshop, Boulder, CO October 15-16 2012  

E-Print Network [OSTI]

This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The workshop was arranged to bring Department of Defense personnel together with experts in microbial ecology, ...

Gilbert, Jack A

215

A Systematic Study of Matrix Acidizing Treatments Using Skin Monitoring Method  

E-Print Network [OSTI]

The goal of this work was to evaluate matrix acidizing treatments of vertical and horizontal wells in carbonate reservoirs. Twenty field cases for acidizing treatments were analyzed by evaluating the skin factor evolution from on-site rate...

Pandya, Nimish

2012-07-16T23:59:59.000Z

216

Symmetry energy, neutron skin, and neutron star radius from chiral effective field theory interactions  

E-Print Network [OSTI]

We discuss neutron matter calculations based on chiral effective field theory interactions and their predictions for the symmetry energy, the neutron skin of 208 Pb, and for the radius of neutron stars.

K. Hebeler; A. Schwenk

2014-01-22T23:59:59.000Z

217

FRACTURE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES  

E-Print Network [OSTI]

FRACTURE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES by Darrin John to the other graduate students in the composite materials group for your smiles and friendships over the past Material .........................................................................................10

218

Design and fabrication of an optical pressure micro sensor for skin mechanics studies  

E-Print Network [OSTI]

The mechanics of skin is as central to touch as optics is to vision and acoustics is to hearing. With the advent of novel imaging technologies such as the Optical Coherence Tomography (OCT), we are now able to view structures ...

Kumar, Siddarth

2006-01-01T23:59:59.000Z

219

Hair follicles are required for optimal growth during lateral skin expansion   

E-Print Network [OSTI]

The hair follicles and the interfollicular epidermis of intact mature skin are maintained by distinct stem cell populations. Upon wounding, however, emigration of hair follicle keratinocytes to the interfollicular epidermis plays a role in acute...

Heath, Jack; Langton, Abigail K.; Hammond, Nigel L.; Dixon, Michael J.; Overbeek, Paul A.

2009-01-01T23:59:59.000Z

220

Publish by Abstract RNA Extraction From Different Apple Tissues  

E-Print Network [OSTI]

Publish by Abstract RNA Extraction From Different Apple Tissues Rich in Polyphenols. An efficient procedure for isolating RNA from bud, internodal shoot, flower, and fruit tissues of apple has in apple fruit and flower tissues. Isolated RNA is of high qual- ity and is undegraded as assessed

Korban, Schuyler S.

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Quantitative Analysis of Developing Tissues Stanislav Y. Shvartsman  

E-Print Network [OSTI]

, they can be used to guide the design of man-made tissues. Epithelial Patterning: a "unit operation and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544 DOI 10 ago, and its aim was defined as design and repair of tissues and organs.1 Tissues are hierarchically

Shvartsman, Stanislav "Stas"

222

Development and Construction of Bioclimatic Double Skin Active Facade for Hot and Humid Climate of UAE  

E-Print Network [OSTI]

tracking venetian blinds, LED (light emitting diodes) lighting and Building Management system. 1.01 Modeling And Simulation Of Double Skin Active Facade The modeling and simulation of the Double Skin Fa?ade Cavity is a complicated task, since... sweating/condensation on the water coil. 3.06 LED (Light Emitting Diode) Lighting The building is illuminated using extremely energy efficient LED?s which last 5 times as long as fluorescents and 50 times longer than typical incandescent. So...

Karbor, R. G.; Mohamed, I.

2010-01-01T23:59:59.000Z

223

Electronic equilibrium as a function of depth in tissue from Cobalt-60 point source exposures  

E-Print Network [OSTI]

. Skin exposure can arise from both the beta and gamma components of radioactive particles and gamma radiation can contribute significantly to skin doses. The gamma component of dose increases dramatically when layers of protective clothing are interposed...

Myrick, Jo Ann

1994-01-01T23:59:59.000Z

224

Relevance of in vivo models in melanoma skin cancer  

SciTech Connect (OSTI)

A discussion of possible wavelength dependence of induction of cutaneous malignant melanoma (CMM) is provided. Strengths and weaknesses of various experimental approaches to better understanding of the prevalence of CMM in different human populations including latitude effects are compared. Further the advantages and limitations of the use of the laboratory opossum (Monodelphis domestic), transgenic mice containing SV40 ongogene sequences under tyrosinase promoter control, and a backcross hybrid fish of the genus Xenophorus are contrasted.

Setlow, R.B.

1995-12-31T23:59:59.000Z

225

Soft-Tissue-Anchored Transcutaneous Port for Long-Term Percutaneous Transhepatic Biliary Drainage  

SciTech Connect (OSTI)

Purpose. A transcutaneous port (T-port) has been developed allowing easy exchange of a catheter, which was fixed inside the device, using the Seldinger technique. The objective of the study was to test the T-port in patients who had percutaneous transhepatic biliary drainage (PTBD). Methods. The T-port, made of titanium, was implanted using local anesthesia in 11 patients (mean age 65 years, range 52-85 years) with biliary duct obstruction (7 malignant and 4 benign strictures). The subcutaneous part of the T-port consisted of a flange with several perforations allowing ingrowth of connective tissue. The T-port allowed catheter sizes of 10 and 12 Fr. Results. All wounds healed uneventfully and were followed by a stable period without signs of pronounced inflammation or infection. It was easy to open the port and to exchange the drainage tube. The patient's quality of life was considerably improved even though several patients had problems with repeated bile leakage due to frequent recurrent obstructions of the tubes. The ports were implanted for a mean time of 9 months (range 2-21 months). Histologic examination in four cases showed that the port was well integrated into the soft tissue. Tilting of the T-port in two cases led to perforation of the skin by the subcutaneous part of the ports, which were removed after 7 and 8 months. Conclusion. The T-port served as an excellent external access to the biliary ducts. The drainage tubes were well fixed within the ports. The quality of life of the patients was considerably improved. Together with improved aesthetic appearance they found it easier to conduct normal daily activities and personal care. However, the problem of recurrent catheter obstruction remained unsolved.

Nyman, Rickard, E-mail: rickard.nyman@akademiska.se; Ekloef, Hampus; Eriksson, Lars-Gunnar [University Hospital, Department of Diagnostic Radiology (Sweden); Karlsson, Britt-Marie; Rasmussen, Ib [University Hospital, Department of Surgery (Sweden); Lundgren, Dan; Thomsen, Peter [Goeteborg University, Biomaterials/Cell Biology (Sweden)

2005-01-15T23:59:59.000Z

226

Influence of neutron-skin thickness on $?^{-}/?^{+}$ ratio in Pb+Pb collisions  

E-Print Network [OSTI]

Within an isospin- and momentum-dependent transport model IBUU11 using as an input nucleon density profiles from Hartree-Fock calculations based on a modified Skyrme-like (MSL) model, we study the influence of the uncertainty of the neutron skin thickness on the $\\pi^{-}/\\pi^{+}$ ratio in both central and peripheral Pb+Pb collisions at beam energies of 400 MeV/nucleon and 1000 MeV/nucleon. Within the current experimental uncertainty range of neutron skin in $^{208}$Pb, while the neutron skin effect on the \\rpi ratio is negligible in central reactions at both energies, it increases gradually with increasing impact parameter and becomes comparable with or even larger than the symmetry energy effect in peripheral collisions especially at 400 MeV/nucleon. Moreover, we found that while the \\rpi ratio is larger with a softer \\esym in central collisions, above certain impact parameters depending on the size of the neutron skin, a stiffer \\esym can lead to a larger \\rpi ratio as most of the pions are produced at densities below the saturation density in these peripheral reactions. Thus, a clear impact parameter selection is important to extract reliable information about the \\esym at suprasaturation densities (size of neutron skin) from the $\\pi^-/\\pi^+$ ratio in central (peripheral) heavy-ion collisions.

Gao-Feng Wei; Bao-An Li; Jun Xu; Lie-Wen Chen

2015-01-21T23:59:59.000Z

227

Illusory Sense of Human Touch from a Warm and Soft Artificial Hand  

E-Print Network [OSTI]

To touch and be touched are vital to human development, well being, and relationships. However, to those who have lost their arms and hands due to accident or war, touching becomes a serious concern that often leads to psychosocial issues and social stigma. In this paper, we demonstrate that the touch from a warm and soft rubber hand can be perceived by another person as if the touch were coming from a human hand. We describe a three step process toward this goal. First, we made participants select artificial skin samples according to their preferred warmth and softness characteristics. At room temperature, the preferred warmth was found to be 28.4 deg C at the skin surface of a soft silicone rubber material that has a Shore durometer value of 30 at the OO scale. Second, we developed a process to create a rubber hand replica of a human hand. To compare the skin softness of a human hand and artificial hands, a robotic indenter was employed to produce a softness map by recording the displacement data when const...

Cabibihan, John-John; Srinivasa, Yeshwin Mysore; Chan, Mark Aaron; Muruganantham, Arrchana

2015-01-01T23:59:59.000Z

228

antiretroviral tissue kinetics: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Models of Multicellular Growing Systems to Macroscopic Biological Tissue Models A, Maroc b Dipartimento di Matematica, Politecnico di Torino, Torino, Italy Abstract This paper...

229

An Automated Platform for High-Resolution Tissue Imaging Using...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

entire image is acquired. The performance of the system is demonstrated by imaging rat brain tissue sections. High resolution mass analysis combined with MSMS experiments enabled...

230

adipose tissue assessing: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

into mitochondria. When Boyer, Edmond 35 New CT imaging method for adipose tissue analysis in mouse model of obesity SYLVAIN ORDUREAU Physics Websites Summary: New CT imaging...

231

adipose tissue assessed: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

into mitochondria. When Boyer, Edmond 35 New CT imaging method for adipose tissue analysis in mouse model of obesity SYLVAIN ORDUREAU Physics Websites Summary: New CT imaging...

232

adipose tissue lipolysis: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fitzgibbons, Timothy P. 2012-01-01 5 Factors controlling brown adipose tissue development D. RICQUIER, G. MORY, F. BOUILLAUD, Michle COMBES-GEORGE Computer Technologies and...

233

adipose tissue mitochondria: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

25 Next Page Last Page Topic Index 1 Factors controlling brown adipose tissue development D. RICQUIER, G. MORY, F. BOUILLAUD, Michle COMBES-GEORGE Computer Technologies and...

234

adipose tissue development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Elizabeth J. 1988-01-01 3 Factors controlling brown adipose tissue development D. RICQUIER, G. MORY, F. BOUILLAUD, Michle COMBES-GEORGE Computer Technologies and...

235

adipose tissue layer: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

236

adipose tissue oestrogen: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

237

adipose tissue reference: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

238

adipose tissue stromal: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

239

adipose tissue studies: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

240

adipose tissue implications: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

adipose tissue expansion: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

242

adipose tissue provoke: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

243

adipose tissue lipoprotein: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

244

adipose tissue distribution: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

245

avian adipose tissue: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

246

adipose tissue: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

247

adipose tissue depending: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

248

adipose tissue engineering: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

249

adipose tissue characteristics: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

250

adipose tissue fibrosis: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

251

adipose tissue blood: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

252

adipose tissue reveals: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

253

adipose tissue show: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

254

adipose tissue inflammation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

255

adipose tissue layers: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

256

adipose tissue treatment: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

257

adipose tissue polysynaptically: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

258

adipose tissue serves: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

259

adipose tissue interstitial: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

260

adipose tissue cultures: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Oxygen Delivery Strategies in Tissue-Engineering Constructs.  

E-Print Network [OSTI]

??The supply of nutrients and the removal of waste products play a major role in tissue engineering. From all the nutrients necessary for cells seeded… (more)

Seifu, Dawit Gezahegn

2012-01-01T23:59:59.000Z

262

Quantification of total mercury in liver and heart tissue of Harbor Seals (Phoca vitulina) from Alaska USA  

SciTech Connect (OSTI)

This study quantified the Hg levels in the liver (n=98) and heart (n=43) tissues of Harbor Seals (Phoca vitulina) (n=102) harvested from Prince William Sound and Kodiak Island Alaska. Mercury tissue dry weight (dw) concentrations in the liver ranged from 1.7 to 393 ppm dw, and in the heart from 0.19 to 4.99 ppm dw. Results of this study indicate liver and heart tissues' Hg ppm dw concentrations significantly increase with age. Male Harbor Seals bioaccumulated Hg in both their liver and heart tissues at a significantly faster rate than females. The liver Hg bioaccumulation rates between the harvest locations Kodiak Island and Prince William Sound were not found to be significantly different. On adsorption Hg is transported throughout the Harbor Seal's body with the partition coefficient higher for the liver than the heart. No significant differences in the bio-distribution (liver:heart Hg ppm dw ratios (n=38)) values were found with respect to either age, sex or geographic harvest location. In this study the age at which Hg liver and heart bioaccumulation levels become significantly distinct in male and female Harbor Seals were identified through a Tukey's analysis. Of notably concern to human health was a male Harbor Seal's liver tissue harvested from Kodiak Island region. Mercury accumulation in this sample tissue was determined through a Q-test to be an outlier, having far higher Hg concentrarion (liver 392 Hg ppm dw) than the general population sampled. - Highlights: Black-Right-Pointing-Pointer Mercury accumulation in the liver and heart of seals exceed food safety guidelines. Black-Right-Pointing-Pointer Accumulation rate is greater in males than females with age. Black-Right-Pointing-Pointer Liver mercury accumulation is greater than in the heart tissues. Black-Right-Pointing-Pointer Mercury determination by USA EPA Method 7473 using thermal decomposition.

Marino, Kady B. [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States)] [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States); Hoover-Miller, Anne; Conlon, Suzanne; Prewitt, Jill [Alaska SeaLife Center, City of Seward, AK (United States)] [Alaska SeaLife Center, City of Seward, AK (United States); O'Shea, Stephen K., E-mail: soshea@rwu.edu [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States)

2011-11-15T23:59:59.000Z

263

Limitations of the TG-43 formalism for skin high-dose-rate brachytherapy dose calculations  

SciTech Connect (OSTI)

Purpose: In skin high-dose-rate (HDR) brachytherapy, sources are located outside, in contact with, or implanted at some depth below the skin surface. Most treatment planning systems use the TG-43 formalism, which is based on single-source dose superposition within an infinite water medium without accounting for the true geometry in which conditions for scattered radiation are altered by the presence of air. The purpose of this study is to evaluate the dosimetric limitations of the TG-43 formalism in HDR skin brachytherapy and the potential clinical impact. Methods: Dose rate distributions of typical configurations used in skin brachytherapy were obtained: a 5 cm × 5 cm superficial mould; a source inside a catheter located at the skin surface with and without backscatter bolus; and a typical interstitial implant consisting of an HDR source in a catheter located at a depth of 0.5 cm. Commercially available HDR{sup 60}Co and {sup 192}Ir sources and a hypothetical {sup 169}Yb source were considered. The Geant4 Monte Carlo radiation transport code was used to estimate dose rate distributions for the configurations considered. These results were then compared to those obtained with the TG-43 dose calculation formalism. In particular, the influence of adding bolus material over the implant was studied. Results: For a 5 cm × 5 cm{sup 192}Ir superficial mould and 0.5 cm prescription depth, dose differences in comparison to the TG-43 method were about ?3%. When the source was positioned at the skin surface, dose differences were smaller than ?1% for {sup 60}Co and {sup 192}Ir, yet ?3% for {sup 169}Yb. For the interstitial implant, dose differences at the skin surface were ?7% for {sup 60}Co, ?0.6% for {sup 192}Ir, and ?2.5% for {sup 169}Yb. Conclusions: This study indicates the following: (i) for the superficial mould, no bolus is needed; (ii) when the source is in contact with the skin surface, no bolus is needed for either {sup 60}Co and {sup 192}Ir. For lower energy radionuclides like {sup 169}Yb, bolus may be needed; and (iii) for the interstitial case, at least a 0.1 cm bolus is advised for {sup 60}Co to avoid underdosing superficial target layers. For {sup 192}Ir and {sup 169}Yb, no bolus is needed. For those cases where no bolus is needed, its use might be detrimental as the lack of radiation scatter may be beneficial to the patient, although the 2% tolerance for dose calculation accuracy recommended in the AAPM TG-56 report is not fulfilled.

Granero, Domingo, E-mail: dgranero@eresa.com [Department of Radiation Physics, ERESA, Hospital General Universitario, 46014 Valencia (Spain)] [Department of Radiation Physics, ERESA, Hospital General Universitario, 46014 Valencia (Spain); Perez-Calatayud, Jose [Radiotherapy Department, La Fe University and Polytechnic Hospital, Valencia 46026 (Spain)] [Radiotherapy Department, La Fe University and Polytechnic Hospital, Valencia 46026 (Spain); Vijande, Javier [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100, Spain and IFIC (UV-CSIC), Paterna 46980 (Spain)] [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100, Spain and IFIC (UV-CSIC), Paterna 46980 (Spain); Ballester, Facundo [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain)] [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Rivard, Mark J. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)] [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)

2014-02-15T23:59:59.000Z

264

Chronic cellular responses of rat skin to 13 Mev proton irradiation  

E-Print Network [OSTI]

CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

Hinkle, Donald King

1966-01-01T23:59:59.000Z

265

Adaptive processing of thin structures to augment segmentation of dual-channel structural MRI of the human brain   

E-Print Network [OSTI]

This thesis presents a method for the segmentation of dual-channel structural magnetic resonance imaging (MRI) volumes of the human brain into four tissue classes. The state-of-the-art FSL FAST segmentation software ...

Withers, James

2010-01-01T23:59:59.000Z

266

New Electronic Sensors Stick to Your Skin -Heart Rate Monitors -Popular Mechanics http://www.popularmechanics.com/science/health/breakthroughs/new-electronic-sensors-stick-to-your-skin?click=pm_latest[8/14/2011 5:59:45 AM  

E-Print Network [OSTI]

New Electronic Sensors Stick to Your Skin - Heart Rate Monitors - Popular Mechanics http://www Electronic Sensors That Stick to Your Skin Like Temporary Tattoos Nice tattoo. Or is it a heart-rate monitor to measure the electrical activity of the heart, muscles and brain. And using the same principles behind

Rogers, John A.

267

DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE  

E-Print Network [OSTI]

DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted to Texas A&M University in partial) __________________________ Ian S. Russell (Member) __________________________ Wei Zhao (Head of Department

268

Williams Syndrome Tissue Donor Information and Registration Packet  

E-Print Network [OSTI]

for by The Salk Institute for Biological Studies and University of Maryland Brain and Tissue Bank. All major are donating the key to that treasure to future generations. Dr. Rodriguez , NICHD Brain Bank, Miami We would and families to make precious brain tissue available to scientists in order to advance Williams syndrome

Bellugi, Ursula

269

Discriminative, Semantic Segmentation of Brain Tissue in MR Images  

E-Print Network [OSTI]

Discriminative, Semantic Segmentation of Brain Tissue in MR Images Zhao Yi1 , Antonio Criminisi2 , Jamie Shotton2 , and Andrew Blake2 1 University of California, Los Angeles, USA. zyi@ucla.edu. 2 is presented for the automatic segmentation and classification of brain tissue from 3D MR scans. It uses

Soatto, Stefano

270

LUCIFERASE ASSAY PROTOCOL FROM TRANSFORMED TISSUE Special Note  

E-Print Network [OSTI]

LUCIFERASE ASSAY PROTOCOL FROM TRANSFORMED TISSUE Special Note: The Luciferase enzyme is unstable-ground samples. 2. Collect liquid nitrogen from downstairs and place 24 frozen tissue samples inside. 3. Place the power. 14.The luminometer cuvettes can be reused, BUT ONLY if they have been thoroughly soaked

Raizada, Manish N.

271

Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro  

E-Print Network [OSTI]

( 0 2 ) 0 0 0 5 8 - 3 #12;of this class of compounds, acrolein and 4-hydroxynonenal (HNE), are known

Crawford, T. Daniel

272

Brown Adipose Tissue Quantification in Human Neonates Using Water-Fat Separated MRI  

E-Print Network [OSTI]

1) derived directly from the Siemens operating system, aMRI was performed on a Siemens 3 T Tim Trio system (VB17the re-shim and default Siemens pre-scan preparations. The

2013-01-01T23:59:59.000Z

273

Beyond differential expression : methods and tools for mining the transcriptomic landscape of human tissue and disease  

E-Print Network [OSTI]

Although there are a variety of high-throughput technologies used to perform biological experiments, DNA microarrays have become a standard tool in the modern biologist's arsenal. Microarray experiments provide measurements ...

Schmid, Patrick R. (Patrick Raphael)

2012-01-01T23:59:59.000Z

274

SciTech Connect: Genome Wide Evaluation of Normal Human Tissue in Response  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBi (2) Sr (2) Ca (2) Cu (3) Oheavy-ionmicrofluidicModelingcarbonto

275

Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora  

E-Print Network [OSTI]

Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora J. Michael Conlona,*, Agnes Sonnevendb , Carlos Davidsonc , Anni Demandtd , Thierry Jouennee-stimulated skin secretions of the Northern red-legged frog Rana aurora aurora and their primary structures

Davidson, Carlos

276

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and  

E-Print Network [OSTI]

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species J. Michael Conlon a, *, Nadia Al-Ghafari a , Laurent peptides Rana aurora Rana draytonii Skin secretions a b s t r a c t The northern red-legged frog Rana

Davidson, Carlos

277

Estimating dose to implantable cardioverter-defibrillator outside the treatment fields using a skin QED diode, optically stimulated luminescent dosimeters, and LiF thermoluminescent dosimeters  

SciTech Connect (OSTI)

The purpose of this work was to determine the relative sensitivity of skin QED diodes, optically stimulated luminescent dosimeters (OSLDs) (microStar Trade-Mark-Sign DOT, Landauer), and LiF thermoluminescent dosimeters (TLDs) as a function of distance from a photon beam field edge when applied to measure dose at out-of-field points. These detectors have been used to estimate radiation dose to patients' implantable cardioverter-defibrillators (ICDs) located outside the treatment field. The ICDs have a thin outer case made of 0.4- to 0.6-mm-thick titanium ({approx}2.4-mm tissue equivalent). A 5-mm bolus, being the equivalent depth of the devices under the patient's skin, was placed over the ICDs. Response per unit absorbed dose-to-water was measured for each of the dosimeters with and without bolus on the beam central axis (CAX) and at a distance up to 20 cm from the CAX. Doses were measured with an ionization chamber at various depths for 6- and 15-MV x-rays on a Varian Clinac-iX linear accelerator. Relative sensitivity of the detectors was determined as the ratio of the sensitivity at each off-axis distance to that at the CAX. The detector sensitivity as a function of the distance from the field edge changed by {+-} 3% (1-11%) for LiF TLD-700, decreased by 10% (5-21%) for OSLD, and increased by 16% (11-19%) for the skin QED diode (Sun Nuclear Corp.) at the equivalent depth of 5 mm for 6- or 15-MV photon energies. Our results showed that the use of bolus with proper thickness (i.e., {approx}d{sub max} of the photon energy) on the top of the ICD would reduce the scattered dose to a lower level. Dosimeters should be calibrated out-of-field and preferably with bolus equal in thickness to the depth of interest. This can be readily performed in clinic.

Chan, Maria F., E-mail: chanm@mskcc.org [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Song, Yulin; Dauer, Lawrence T.; Li Jingdong; Huang, David; Burman, Chandra [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2012-10-01T23:59:59.000Z

278

Human-machine interactions  

SciTech Connect (OSTI)

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

279

Evaluation and design of double-skin facades for office buildings in hot climates  

E-Print Network [OSTI]

efficient strategy and also the factors that affected this efficiency. The simulations were done using the building simulation software, Ener-Win. The double skin was simulated as per an approximate and simplistic calculation of the u-value, solar heat gain...

Yellamraju, Vijaya

2004-09-30T23:59:59.000Z

280

The average person sheds 40 pounds of skin during his or her lifetime. That's the  

E-Print Network [OSTI]

Q: MSU N 19 o. The average person sheds 40 pounds of skin during his or her lifetime. That whether they are facts or opinions. Fact or opinion? A fact is something that can be tested. An opinion is something that someone thinks or believes. 1. Wooly mammoths are extinct. fact opinion 2. Ear wax can

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Have we observed the skin vibration of realistic strange stars (ReSS) ?  

E-Print Network [OSTI]

Skin vibration of ReSS and consequent resonance absorption can account for the absorption lines in the spectrum of X-ray emission from many compact stellar objects and in particular, the stars J1210$-$5226 and RXJ1856$-$3754. Observations of the X-ray spectrum of these stars is difficult to explain, if they are neutron stars.

Monika Sinha; Jishnu Dey; Mira Dey; Subharthi Ray; Siddhartha Bhowmick

2002-11-27T23:59:59.000Z

282

Water skin anomalies: density, elasticity, hydrophobicity, thermal stability, interface repulsivity, etc  

E-Print Network [OSTI]

Molecular undercoordination induced O:H-O bond relaxation and dual polarization dictates the supersolid behavior of water skins interacting with other substances such as flowing in nanochannels, dancing of water droplets, floating of insects. The BOLS-NEP notion unifies the Wenzel-Cassie-Baxter models and explains controllable transition between hydrophobicity and hydrophilicity.

Chang Q. Sun

2015-02-26T23:59:59.000Z

283

ON THE INFLUENCE OF THE GEOMETRY ON SKIN EFFECT IN ELECTROMAGNETISM  

E-Print Network [OSTI]

ON THE INFLUENCE OF THE GEOMETRY ON SKIN EFFECT IN ELECTROMAGNETISM GABRIEL CALOZ, MONIQUE DAUGE, ERWAN FAOU, VICTOR P´ERON ABSTRACT. We consider the equations of electromagnetism set on a domain made in electromagnetism. This effect describes the rapid decay of electromagnetic fields with depth inside a metallic

Dauge, Monique

284

CancerTherapy Skin Cooling Anthony Alleman, Duane Bywaters, David Chadburn, Drew Sparks  

E-Print Network [OSTI]

printed cooling pad with 9 ports, the final cooling pad is ABS 3D printed with a curved surface and 11 ports. ABS 3D printed CP with inner channel and 9 ports, vertical flow. 11 ports angled towards membrane ultrasound procedure to concentrate acoustic energy beneath the skin's Required heat transfer coefficients

Provancher, William

285

Original Contribution Arsenic Exposure from Drinking Water and Risk of Premalignant Skin Lesions  

E-Print Network [OSTI]

Original Contribution Arsenic Exposure from Drinking Water and Risk of Premalignant Skin Lesions, 2006. Millions of persons around the world are exposed to low doses of arsenic through drinking water from drinking water over a significant period of time. The authors evaluated dose-response relations

van Geen, Alexander

286

Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells  

SciTech Connect (OSTI)

A major problem in the treatment of type 1 diabetes mellitus is the limited availability of alternative sources of insulin-producing cells for islet transplantation. In this study, we investigated the effect of bone morphogenetic protein 4 (BMP-4) treatments of gnotobiotic porcine skin-derived stem cells (gSDSCs) on their reprogramming and subsequent differentiation into insulin-producing cells (IPCs). We isolated SDSCs from the ear skin of a gnotobiotic pig. During the proliferation period, the cells expressed stem-cell markers Oct-4, Sox-2, and CD90; nestin expression also increased significantly. The cells could differentiate into IPCs after treatments with activin-A, glucagon-like peptide-1 (GLP-1), and nicotinamide. After 15 days in the differentiation medium, controlled gSDSCs began expressing endocrine progenitor genes and proteins (Ngn3, Neuro-D, PDX-1, NKX2.2, NKX6.1, and insulin). The IPCs showed increased insulin synthesis after glucose stimulation. The results indicate that stem cells derived from the skin of gnotobiotic pigs can differentiate into IPCs under the appropriate conditions in vitro. Our three-stage induction protocol could be applied without genetic modification to source IPCs from stem cells in the skin of patients with diabetes for autologous transplantation.

Yang, Ji Hoon; Lee, Sung Ho; Heo, Young Tae [Department of Bioscience and Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)] [Department of Bioscience and Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of); Uhm, Sang Jun [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)] [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of); Lee, Hoon Taek, E-mail: htl3675@konkuk.ac.kr [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)

2010-07-09T23:59:59.000Z

287

Microfluidics for Tissue and Cell Applications JST CREST, "Cell and Tissue Showcasing by Micro-Nano Integrated Devices" Project  

E-Print Network [OSTI]

Microfluidics for Tissue and Cell Applications JST CREST, "Cell and Tissue Showcasing by Micro-Nano Integrated Devices" Project JST-VINNOVA/SSF SICP, "Microfluidic Cancer Diagnosis Platform" Project JST ERATO 2 : Prof. Shuichi Takayama (University of Michigan) "Microfluidic Tools to Model and Analyze

Tokyo, University of

288

Lasers in Surgery and Medicine 38:137141 (2006) Thermal Responses of Ex Vivo Human Skin During Multiple  

E-Print Network [OSTI]

Departamento de Optica, Instituto Nacional de Astrofisica, Optica y Electronica, Puebla, Mexico 3 Department

Aguilar, Guillermo

289

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

SciTech Connect (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-ÎşB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-ÎşB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

290

Transport Pathways and Enhancement Mechanisms within Localized and Non-Localized Transport Regions in Skin Treated with Low-Frequency Sonophoresis and Sodium Lauryl Sulfate  

E-Print Network [OSTI]

Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not homogenous across the skin surface. Instead, ...

Polat, Baris E.

291

CT volumetry of the skeletal tissues  

SciTech Connect (OSTI)

Computed tomography (CT) is an important and widely used modality in the diagnosis and treatment of various cancers. In the field of molecular radiotherapy, the use of spongiosa volume (combined tissues of the bone marrow and bone trabeculae) has been suggested as a means to improve the patient-specificity of bone marrow dose estimates. The noninvasive estimation of an organ volume comes with some degree of error or variation from the true organ volume. The present study explores the ability to obtain estimates of spongiosa volume or its surrogate via manual image segmentation. The variation among different segmentation raters was explored and found not to be statistically significant (p value >0.05). Accuracy was assessed by having several raters manually segment a polyvinyl chloride (PVC) pipe with known volumes. Segmentation of the outer region of the PVC pipe resulted in mean percent errors as great as 15% while segmentation of the pipe's inner region resulted in mean percent errors within {approx}5%. Differences between volumes estimated with the high-resolution CT data set (typical of ex vivo skeletal scans) and the low-resolution CT data set (typical of in vivo skeletal scans) were also explored using both patient CT images and a PVC pipe phantom. While a statistically significant difference (p value <0.002) between the high-resolution and low-resolution data sets was observed with excised femoral heads obtained following total hip arthroplasty, the mean difference between high-resolution and low-resolution data sets was found to be only 1.24 and 2.18 cm{sup 3} for spongiosa and cortical bone, respectively. With respect to differences observed with the PVC pipe, the variation between the high-resolution and low-resolution mean percent errors was a high as {approx}20% for the outer region volume estimates and only as high as {approx}6% for the inner region volume estimates. The findings from this study suggest that manual segmentation is a reasonably accurate and reliable means for the in vivo estimation of spongiosa volume. This work also provides a foundation for future studies where spongiosa volumes are estimated by various raters in more comprehensive CT data sets.

Brindle, James M.; Alexandre Trindade, A.; Pichardo, Jose C.; Myers, Scott L.; Shah, Amish P.; Bolch, Wesley E. [Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States); Department of Statistics, University of Florida, Gainesville, Florida 32611 (United States); Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States); Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, Florida 32611 (United States); MD Anderson Cancer Center Orlando, Orlando, Florida 32806 (United States); Department of Nuclear and Radiological and Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States)

2006-10-15T23:59:59.000Z

292

DIVISION OF HUMAN RESOURCES  

E-Print Network [OSTI]

you sneeze or cough; cough or sneeze into a tissue and dispose of used tissues. Wash your hands after sneezing or coughing. Avoid touching your eyes, nose or mouth. Avoid others with respiratory illnesses/or cough stuffy nose and /or chills headache, body aches, and /or fatigue Some people with H1N1 flu also

Salama, Khaled

293

Regeneration of Tissues and Organs Using Autologous Cells  

SciTech Connect (OSTI)

The proposed work aims to address three major challenges to the field of regenerative medicine: 1) the growth and expansion of regenerative cells outside the body in controlled in vitro environments, 2) supportive vascular supply for large tissue engineered constructs, and 3) interactive biomaterials that can orchestrate tissue development in vivo. Toward this goal, we have engaged a team of scientists with expertise in cell and molecular biology, physiology, biomaterials, controlled release, nanomaterials, tissue engineering, bioengineering, and clinical medicine to address all three challenges. This combination of resources, combined with the vast infrastructure of the WFIRM, have brought to bear on projects to discover and test new sources of autologous cells that can be used therapeutically, novel methods to improve vascular support for engineered tissues in vivo, and to develop intelligent biomaterials and bioreactor systems that interact favorably with stem and progenitor cells to drive tissue maturation. The Instituteâ??s ongoing programs are aimed at developing regenerative medicine technologies that employ a patientâ??s own cells to help restore or replace tissue and organ function. This DOE program has provided a means to solve some of the vexing problems that are germane to many tissue engineering applications, regardless of tissue type or target disease. By providing new methods that are the underpinning of tissue engineering, this program facilitated advances that can be applied to conditions including heart disease, diabetes, renal failure, nerve damage, vascular disease, and cancer, to name a few. These types of conditions affect millions of Americans at a cost of more than $400 billion annually. Regenerative medicine holds the promise of harnessing the bodyâ??s own power to heal itself. By addressing the fundamental challenges of this field in a comprehensive and focused fashion, this DOE program has opened new opportunities to treat conditions where other approaches have failed.

Anthony Atala, M.D.

2012-10-11T23:59:59.000Z

294

Introduction Uniform Estimates for Transmission Problems 3D Multiscaled Asymptotic Expansion Numerical Simulations Skin-Effect Description in Electromagnetism with a  

E-Print Network [OSTI]

Numerical Simulations Skin-Effect Description in Electromagnetism with a Scaled Asymptotic Expansion Gabriel.08.2009 V. P´eron Skin-Effect Description in Electromagnetism with a Scaled Asymptotic Expansion 1 / 32 and Electromagnetism MONIQUE DAUGE, ERWAN FAOU, VICTOR P ´ERON (2009) Asymptotic Behavior at High Conductivity of Skin

Paris-Sud XI, Université de

295

Cognitive Science (Humanities)  

E-Print Network [OSTI]

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

296

Injectable hyaluronic acid scaffolds for cartilage tissue engineering  

E-Print Network [OSTI]

Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very ...

Ren, Cindy D

2008-01-01T23:59:59.000Z

297

Design, construction and implementation of spherical tissue equivalent proportional counter  

E-Print Network [OSTI]

Tissue equivalent proportional counters (TEPC) are used for medical and space activities whenever a combination of high and low LET (lineal energy transfer) radiations are present. With the frequency and duration of space activities increasing...

Perez Nunez, Delia Josefina

2009-05-15T23:59:59.000Z

298

Increasing the safety and precision of medical tissue puncture  

E-Print Network [OSTI]

Tissue puncture is ubiquitous in medicine, from percutaneous injections and biopsies to laparoscopic surgical access, epidural anesthesia, and cranial drilling; over 10 million puncture procedures are performed each year ...

Begg, Nikolai David Michael

2014-01-01T23:59:59.000Z

299

Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging  

E-Print Network [OSTI]

Tissue engineering can be applied to develop therapeutic techniques for osteoarthritis, a degenerative disease caused by the progressive deterioration of cartilage in joints. An inherent goal in developing cartilage-replacement ...

Casasnovas Ortega, Nicole

2012-01-01T23:59:59.000Z

300

Perfused multiwell plate for 3D liver tissue engineering  

E-Print Network [OSTI]

In vitro models that capture the complexity of in vivo tissue and organ behaviors in a scalable and easy-to-use format are desirable for drug discovery. To address this, we have developed a bioreactor that fosters maintenance ...

Domansky, Karel

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions  

E-Print Network [OSTI]

This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

Macdonald, Mara Lee

2010-01-01T23:59:59.000Z

302

Driving tissue morphogenetic cascades using tunable nanolayered surface coatings  

E-Print Network [OSTI]

Harnessing the synergy between materials at the nanoscale can be a valuable tool in understanding and probing cellular phenomena and in driving specific processes that lead to tissue and organ regeneration and repair. ...

Shah, Nisarg Jaydeep

2014-01-01T23:59:59.000Z

303

Tissue-specific gene silencing monitored in circulating RNA  

E-Print Network [OSTI]

Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that ...

Sehgal, Alfica

304

Decellularized cartilage as a chondroinductive material for cartilage tissue engineering  

E-Print Network [OSTI]

materials as scaffold components could potentially bridge the gap between scaffolds and signals in the traditional tissue engineering triad, suggesting that the two are not modulated as separate components, but rather as integrated factors that contribute...

Renth, Amanda

2013-12-31T23:59:59.000Z

305

articular cartilage tissue: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for 50% of the equilibrium compressive elastic modulus of the tissue. The bottle-brush-shaped ... Lee, Hsu-Yi 2010-01-01 74 Mechanical injury and inflammatory cytokines...

306

Novel polypyrrole derivatives to enhance conductive polymer-tissue interactions  

E-Print Network [OSTI]

Developing materials that interact effectively with surrounding tissue is a major obstacle in sensor and drug delivery research. The body's natural immune response prevents foreign objects from easily integrating with an ...

George, Paul M. (Paul Matthew)

2005-01-01T23:59:59.000Z

307

adipose tissue pathways: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the expression of the UCP1 gene 293 D. Norepinephrine is an apoptosis inhibitor in brown adipocytes 294 IV. How Significant Is Brown Adipose Tissue? 295 A. Parameters of...

308

adipose tissue gene: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the expression of the UCP1 gene 293 D. Norepinephrine is an apoptosis inhibitor in brown adipocytes 294 IV. How Significant Is Brown Adipose Tissue? 295 A. Parameters of...

309

adipose tissue expression: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the expression of the UCP1 gene 293 D. Norepinephrine is an apoptosis inhibitor in brown adipocytes 294 IV. How Significant Is Brown Adipose Tissue? 295 A. Parameters of...

310

Automation of single-cell techniques in neural tissue  

E-Print Network [OSTI]

The highly heterogeneous nature of cells in the context of native tissue environments necessitates the development of tools and techniques that can manipulate and analyze samples with single-cell resolution. While the past ...

Steinmeyer, Joseph D. (Joseph Daly)

2014-01-01T23:59:59.000Z

311

Distribution and metabolism of antibodies and macromolecules in tumor tissue  

E-Print Network [OSTI]

Tumor targeting drugs that selectively treat cancerous tissue are promising agents for lowering the morbidity and mortality of cancer. Within this field, antibody treatments for cancer are currently being developed for ...

Thurber, Greg M

2008-01-01T23:59:59.000Z

312

Photocrosslinkable Kappa-Carrageenan Hydrogels for Tissue Engineering Applications  

E-Print Network [OSTI]

Kappa carrageenan (?-CA) is a natural-origin polymer that closely mimics the glycosaminoglycan structure, one of the most important constituents of native tissues extracellular matrix. Previously, it has been shown that ...

Mihaila, Silvia M.

313

BE.441 Biomaterials-Tissue Interactions, Fall 2003  

E-Print Network [OSTI]

Principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein ...

Spector, Myron

314

Adipogenesis and angiogenesis : roles in tissue engineering and glucose metabolism  

E-Print Network [OSTI]

Adipose tissue serves two main functions in the body: (1) it is the body's primary energy depot; and (2) it also serves as an important endocrine organ, producing and secreting various enzymes, growth factors, cytokines, ...

Tam, Joshua

2009-01-01T23:59:59.000Z

315

Osteochondral Interface Tissue Engineering using Macroscopic Gradients of Physicochemical Signals  

E-Print Network [OSTI]

of tissue interfaces. Yet, just because tissues are separated from one another by type, function, location, or anatomical prevalence, does not necessarily mean that the interfaces are as easily distinguishable, as the interfaces themselves are highly complex... not yield a “true” continuous gradient, it can have many discrete advantages over continuous gradients. Because of the inherent discontinuous fabrication methods (developing sections separately and fusing together), however, design effort must be placed...

Dormer, Nathan Henry

2011-04-25T23:59:59.000Z

316

Modification of the fatty acid composition of bovine tissues  

E-Print Network [OSTI]

MODIFICATION OF THE FATTY ACID COMPOSITION OF BOVINE TISSUES A Thesis by JOYCE CHANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August... 1990 Major Subject: Nutrition MODIFICATION OF THE FATTY ACID COMPOSITION OF BOVINE TISSUES A Thesis by JOYCE CHANG Approved as to style and content by: Stephen B. Smith (Chair of Committee) Barbara O' Brien (Member) aren S. Kubena (Member...

Chang, Joyce

2012-06-07T23:59:59.000Z

317

Energy-dependence of skin-mode fraction in $E1$ excitations of neutron-rich nuclei  

E-Print Network [OSTI]

We have extensively investigated characters of the low-energy $E1$ strengths in $N>Z$ nuclei, by analyzing the transition densities obtained by the HF+RPA calculations with several effective interactions. Crossover behavior has been confirmed, from the skin mode at low energy to the $pn$ mode at higher energy. Decomposing the $E1$ strengths into the skin-mode, $pn$-mode and interference fractions, we show that the ratio of the skin-mode strength to the full strength may be regarded as a generic function of the excitation energy, insensitive to nuclides and effective interactions, particularly beyond Ni.

Nakada, H; Sawai, H

2015-01-01T23:59:59.000Z

318

Multirobot Lunar Excavation and ISRU Using Artificial-Neural-Tissue Controllers  

SciTech Connect (OSTI)

Automation of site preparation and resource utilization on the Moon with teams of autonomous robots holds considerable promise for establishing a lunar base. Such multirobot autonomous systems would require limited human support infrastructure, complement necessary manned operations and reduce overall mission risk. We present an Artificial Neural Tissue (ANT) architecture as a control system for autonomous multirobot excavation tasks. An ANT approach requires much less human supervision and pre-programmed human expertise than previous techniques. Only a single global fitness function and a set of allowable basis behaviors need be specified. An evolutionary (Darwinian) selection process is used to 'breed' controllers for the task at hand in simulation and the fittest controllers are transferred onto hardware for further validation and testing. ANT facilitates 'machine creativity', with the emergence of novel functionality through a process of self-organized task decomposition of mission goals. ANT based controllers are shown to exhibit self-organization, employ stigmergy (communication mediated through the environment) and make use of templates (unlabeled environmental cues). With lunar in-situ resource utilization (ISRU) efforts in mind, ANT controllers have been tested on a multirobot excavation task in which teams of robots with no explicit supervision can successfully avoid obstacles, interpret excavation blueprints, perform layered digging, avoid burying or trapping other robots and clear/maintain digging routes.

Thangavelautham, Jekanthan; Smith, Alexander; Abu El Samid, Nader; Ho, Alexander; D'Eleuterio, Gabriele M. T. [Institute for Aerospace Studies, University of Toronto, 4925 Dufferin St., Toronto, ON M3H 5T6 (Canada); Boucher, Dale [Northern Centre for Advanced Technology, 1400 Barrydowne Rd., Sudbury, ON P3A 3V8 (Canada); Richard, Jim [Electric Vehicle Controllers Ltd, 2200 ValleyView Rd., Val Caron, ON P3N 1L1 (Canada)

2008-01-21T23:59:59.000Z

319

E-Print Network 3.0 - animal brain tissues Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the nervous system, or we can retrieve all the sub- anatomical tissue types of the brain or head. The tissue... . Therefore, if any EST is from the tissue-type brain, then...

320

Development of a high throughput 3D perfused liver tissue bioreactor  

E-Print Network [OSTI]

This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...

Inman, Samuel Walker

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Influence of the single-particle structure on the nuclear surface and the neutron skin  

E-Print Network [OSTI]

We analyze the influence of the single-particle structure on the neutron density distribution and the neutron skin in Ca, Ni, Zr, Sn, and Pb isotopes. The nucleon density distributions are calculated in the Hartree-Fock+BCS approach with the SLy4 Skyrme force. A close correlation is found between the quantum numbers of the valence neutrons and the changes in the position and the diffuseness of the nuclear surface, which in turn affect the neutron skin thickness. Neutrons in the valence orbitals with low principal quantum number and high angular momentum mainly displace the position of the neutron surface outwards, while neutrons with high principal quantum number and low angular momentum basically increase the diffuseness of the neutron surface. The impact of the valence shell neutrons on the tail of the neutron density distribution is discussed.

M. Warda; M. Centelles; X. Vinas; X. Roca-Maza

2014-04-03T23:59:59.000Z

322

Performance Assessment of Bi-Directional Knotless Tissue-Closure Devices in Juvenile Chinook Salmon Surgically Implanted with Acoustic Transmitters, 2009 - Final Report  

SciTech Connect (OSTI)

The purpose of this report is to assess the performance of bi-directional knotless tissue-closure devices for use in tagging juvenile salmon. This study is part of an ongoing effort at Pacific Northwest National Laboratory (PNNL) to reduce unwanted effects of tags and tagging procedures on the survival and behavior of juvenile salmonids, by assessing and refining suturing techniques, suture materials, and tag burdens. The objective of this study was to compare the performance of the knotless (barbed) suture, using three different suture patterns (treatments: 6-point, Wide “N”, Wide “N” Knot), to the current method of suturing (MonocrylTM monofilament, discontinuous sutures with a 2×2×2×2 knot) used in monitoring and research programs with a novel antiseptic barrier on the wound (“Second Skin”).

Woodley, Christa M.; Wagner, Katie A.; Bryson, Amanda J.

2012-11-09T23:59:59.000Z

323

An evaluation of floor surfaces on the basis of skin temperature during constrained standing  

E-Print Network [OSTI]

popliteal fossa (popliteal region), and the medial side of abductor hallucis on the non-load bearing region of the foot (near the intersection of the top of the arch and the instep) or the foot region. All thermistors were located on the left leg... between an average ending temperature and an average start-up temperature. The foot skin temperature region was the only temperature region to indicate statistically significant results between the floor surfaces. The other two lower leg temperature...

Monford, Leo Gabriel

1995-01-01T23:59:59.000Z

324

Effect of dietary polyunsaturated fatty acid and related nutrients on plasma lipids, and skin and hair coat condition in canines  

E-Print Network [OSTI]

phospholipid fatty acids were determined at each collection period. Serum zinc concentrations were analyzed on wk 12, 14, and 24. The hypothesis was that a diet containing increased LA, ALA, and zinc concentrations (diet C) would show improvements of skin...

Hester, Shaleah Lynnae

2004-11-15T23:59:59.000Z

325

E-Print Network 3.0 - adenomyosis tissue injury Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

tissue after compression injury. An example of 24 h after injury was shown... -bound acrolein in the spinal cord tissue after traumatic injury. (a) Western blotting analysis of...

326

Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

327

Does phentolamine mesylate reverse soft-tissue anesthesia after 3% mepivacaine?  

E-Print Network [OSTI]

reversal of soft-tissue anesthesia after dental procedures.following local anesthesia reversal with phentolamineet al. Reversal of soft-tissue anesthesia with phentolamine

Silvera, Andreia Minasian

2013-01-01T23:59:59.000Z

328

Development of computational and experimental tools to study mechanotransduction in C.elegans and primates  

E-Print Network [OSTI]

When an object comes into contact with the human fingertip, surface loads imposed on the fingerpad are transmitted to thousands of specialized nerve endings embedded in the skin tissue. These nerve endings, called ...

Kumar, Siddarth

2011-01-01T23:59:59.000Z

329

Quantitative studies of rattlesnake (Crotalus atrox: venom, venom fractions, and rabbit antivenom: Lethality, skin sensitivity, and antibody characterization.  

E-Print Network [OSTI]

QUANTITATIVE STUDIES OF RATTLESNAKE (CROTALUS ATROX) VENOM, VENOM FRACTIONS, AND RABBIT ANTIVENOM: LETHALITY, SKIN SENSITIVITY, AND ANTIBODY CHARACTERIZATION A Thesis By RICHARD PATTON BRADBURY Submitted to the Graduate College of the Texas...: LETHALITY, SKIN SENSITIVITY, AND ANTIBODY CHARACTERIZATION A Thesis By RICHARD PATTON BRADBURY Approved as to style and content by: (Chairman of Committee) Q(cf f. 4&a (Member) (Coordinator, Space Medicine (Member) Program and Member) August 1967...

Bradbury, Richard Patton

2012-06-07T23:59:59.000Z

330

Human Resources Assistant  

Broader source: Energy.gov [DOE]

This position is located in the Headquarters (HQ) Operations Division of the Office of the Chief Human Capital Officer in Washington, DC. The Division provides a full range of human capital...

331

Concentrations of Heavy Metals in Selected Tissues of Blue  

E-Print Network [OSTI]

Abstract: Persian Gulf supports diverse ecosystems and biota in need of remediation and protection and metal data from this region is needed. The levels of heavy metals (Fe, Hg, Ni and Pb) in tissues (hepatopancreas, muscle and exoskeleton) of blue swimming crab, Portunus pelagicus and sediments in the Persian Gulf coasts, south Iran were investigated. Heavy metals analysis was performed by Atomic Absorption Spectrophotometer. The concentration of heavy metals in sediments at all sampling stations occurs in descending order of Fe> Ni> Hg> Pb during both seasons. The distribution pattern of heavy metals in the tissues of crab and sediments was as follows: sediment> hepatopancreasn> muscle> exoskeleton. Maximum concentration of the total heavy metals in sediments and all tissues of P. pelagicus observes in Bahrekan station (Pheavy metals in the tissues of the crab P. pelagicus. In present study recorded that there was negligible differences in heavy metals levels between different seasons. Differences in heavy metals concentrations among the species is likely to have resulted from metal bioavailability, hydrodynamics of the environment, changes in tissue composition, stations of collection and sources of pollution within Persian Gulf.

Mehdi Hosseini; Afshin Abdi Bastami; Javad Kazemzadeh Khoei; Maryam Esmailian; Elmira Janmohammadi Songhori; Mina Najafzadeh

332

The effect of head size/shape, miscentering, and bowtie filter on peak patient tissue doses from modern brain perfusion 256-slice CT: How can we minimize the risk for deterministic effects?  

SciTech Connect (OSTI)

Purpose: To determine patient-specific absorbed peak doses to skin, eye lens, brain parenchyma, and cranial red bone marrow (RBM) of adult individuals subjected to low-dose brain perfusion CT studies on a 256-slice CT scanner, and investigate the effect of patient head size/shape, head position during the examination and bowtie filter used on peak tissue doses. Methods: The peak doses to eye lens, skin, brain, and RBM were measured in 106 individual-specific adult head phantoms subjected to the standard low-dose brain perfusion CT on a 256-slice CT scanner using a novel Monte Carlo simulation software dedicated for patient CT dosimetry. Peak tissue doses were compared to corresponding thresholds for induction of cataract, erythema, cerebrovascular disease, and depression of hematopoiesis, respectively. The effects of patient head size/shape, head position during acquisition and bowtie filter used on resulting peak patient tissue doses were investigated. The effect of eye-lens position in the scanned head region was also investigated. The effect of miscentering and use of narrow bowtie filter on image quality was assessed. Results: The mean peak doses to eye lens, skin, brain, and RBM were found to be 124, 120, 95, and 163 mGy, respectively. The effect of patient head size and shape on peak tissue doses was found to be minimal since maximum differences were less than 7%. Patient head miscentering and bowtie filter selection were found to have a considerable effect on peak tissue doses. The peak eye-lens dose saving achieved by elevating head by 4 cm with respect to isocenter and using a narrow wedge filter was found to approach 50%. When the eye lies outside of the primarily irradiated head region, the dose to eye lens was found to drop to less than 20% of the corresponding dose measured when the eye lens was located in the middle of the x-ray beam. Positioning head phantom off-isocenter by 4 cm and employing a narrow wedge filter results in a moderate reduction of signal-to-noise ratio mainly to the peripheral region of the phantom. Conclusions: Despite typical peak doses to skin, eye lens, brain, and RBM from the standard low-dose brain perfusion 256-slice CT protocol are well below the corresponding thresholds for the induction of erythema, cataract, cerebrovascular disease, and depression of hematopoiesis, respectively, every effort should be made toward optimization of the procedure and minimization of dose received by these tissues. The current study provides evidence that the use of the narrower bowtie filter available may considerably reduce peak absorbed dose to all above radiosensitive tissues with minimal deterioration in image quality. Considerable reduction in peak eye-lens dose may also be achieved by positioning patient head center a few centimeters above isocenter during the exposure.

Perisinakis, Kostas; Seimenis, Ioannis; Tzedakis, Antonis; Papadakis, Antonios E.; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece); Medical Diagnostic Center 'Ayios Therissos,' P.O. Box 28405, Nicosia 2033, Cyprus and Department of Medical Physics, Medical School, Democritus University of Thrace, Panepistimioupolis, Dragana 68100, Alexandroupolis (Greece); Department of Medical Physics, University Hospital of Heraklion, P.O. Box 1352, Heraklion 71110, Crete (Greece); Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece)

2013-01-15T23:59:59.000Z

333

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

334

Human Research ProgramHuman Research Program Human System Risk in Exploration and  

E-Print Network [OSTI]

Human System Risks in Exploration Missions 21SEP10 2HRP Risk Process ­ D.Grounds Presentation contentsHuman Research ProgramHuman Research Program Human System Risk in Exploration and the Human Research Program 21SEP10 1HRP Risk Process ­ D Grounds #12;Human Research ProgramHuman Research Program

Waliser, Duane E.

335

Enrichment of selected fatty acids in broiler tissues  

E-Print Network [OSTI]

ENRICHMENT OF SELECTED FATTY ACIDS IN BROILER TISSUES A Thesis by JIA-CHYI YAU Submitted to the Office of Graduate Study of Texas A&M University in partial fullfillment of the requirements for the degree of MASTER OF SCIENCE August 1990... Major Subject: Food Science and Technology ENRICHMENT OF SELECTED FATTY ACIDS IN BROILER TISSUES A Thesis by JIA-CHYI YAU Approved as to style and content by A. R. Sams (Chair of Comittee) C. A. Bailey (Member) J. T Eeet n (M mber) R. Creg...

Yau, Jia-Chyi

2012-06-07T23:59:59.000Z

336

Computer-aided evaluation of protein expression in pathological tissue images Elisa Ficarra, Enrico Macii  

E-Print Network [OSTI]

by pathologists via visual inspection of tissue sam- ples images. Our techniques streamlines this errorComputer-aided evaluation of protein expression in pathological tissue images Elisa Ficarra, Enrico in pathological tissues by using, for example, images of the tissue where the localization of pro- teins, as well

De Micheli, Giovanni

337

Energy loss characteristics of heavy ions in nitrogen, carbon dioxide, argon, hydrocarbon gases and tradescantia tissue  

E-Print Network [OSTI]

Energy loss characteristics of heavy ions in nitrogen, carbon dioxide, argon, hydrocarbon gases and tradescantia tissue

Dennis, J A

1971-01-01T23:59:59.000Z

338

Beagle Dog Tissue Archive (previously part of National Radiobiology Archives): from the Janus Tissue Archive at Northwestern University  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

Following the advent of the atomic age, many nations have investigated the effects of radioactive exposure in animal models. Some of these investigations involved costly and unique experiments that produced tissue and data archives which are unlikely to be reproduced. In an effort to extract the value from these collections, programs have started in Japan, Europe, and America to preserve and make public the data and tissues from these studies for further investigation. The Beagle Dog Experiments, carried out at Argonne National Laboratory from 1952 to 1991 by Thomas Fritz, William Norris, and Tom Seed and supported by grants from the Atomic Energy Commission, investigated the effects of Cobalt-60 radiation on beagle dogs. Documentation from these studies is availible in pdf form. This web portal seeks to make accessible the animal tissues and study data from the Beagle Dog Experiments using data organized by Charles Watson. Use the search form to the left to look for dog data from particular experimental conditions. Click a dog number to return the full dog record. Use the dog record to find tissues of interest and make a sample tissue request. These tissue samples and the data were known until recently as the the U.S. National Radiobiology Archives (NRA) and were maintained as the United States Transuranium and Uranium Registries (USTUR) at Washington State University. Life-span studies using beagle dogs were done at the Argonne National Laboratory, University of California at Davis, Pacific Northwest National Laboratory, Inhalation Toxicology Research Institute, and the University of Utah. The results and many microscope slides from these life-span studies, totaling some 6000 dogs, are now available to researchers. A seminal work included in the Archive is The Atlas of Experimentally-Induced Neoplasia in the Beagle Dog (Watson et al, 1997).

Watson, Charles R.

339

Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication  

SciTech Connect (OSTI)

The objective of the project was to elucidate the mechanisms underlying the biological effects of low dose/low dose rate ionizing radiation in organs/tissues of irradiated mice that differ in their susceptibility to ionizing radiation, and in human cells grown under conditions that mimic the natural in vivo environment. The focus was on the effects of sparsely ionizing cesium-137 gamma rays and the role of oxidative metabolism and intercellular communication in these effects. Four Specific Aims were proposed. The integrated outcome of the experiments performed to investigate these aims has been significant towards developing a scientific basis to more accurately estimate human health risks from exposures to low doses ionizing radiation. By understanding the biochemical and molecular changes induced by low dose radiation, several novel markers associated with mitochondrial functions were identified, which has opened new avenues to investigate metabolic processes that may be affected by such exposure. In particular, a sensitive biomarker that is differentially modulated by low and high dose gamma rays was discovered.

Azzam, Edouard I

2013-01-16T23:59:59.000Z

340

Biomechanics of brain tissue Thibault P. Prevost a  

E-Print Network [OSTI]

, blast/shock wave prop- agation) leading to traumatic brain injury. Ă? 2010 Acta Materialia Inc. Published, viscoelastic constitutive model. Mixed gray and white matter samples excised from the superior cortex were model was developed to account for the essential features of the tissue response over the entire

Suresh, Subra

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Light transport in two-layer tissues Arnold D. Kim  

E-Print Network [OSTI]

theoretically light backscattered by tissues using the radiative transport equation. In particular we consider of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.1925227] Keywords: radiative transport equation's functions and is exact. Hence, one needs only to solve the transport equation in a finite slab using

Kim, Arnold D.

342

Light propagation in biological tissues containing an absorbing plate  

E-Print Network [OSTI]

in the forward direction, we replace the governing radiative transport equation with the Fokker­ Planck equation. Introduction Light propagation in biological tissue is governed by the radiative transport equation.1 approxima- tion to the transport equation.3­8 However, these results are limited by the fact

Kim, Arnold D.

343

Scleral Reinforcement Through Host Tissue Integration with Biomimetic Enzymatically Degradable  

E-Print Network [OSTI]

. Wildsoet, O.D., Ph.D.1 Enzymatically degradable semi-interpenetrating polymer networks (edsIPNs) were Polymer Network James Su, M.Eng.,1 Samuel T. Wall, Ph.D.,2 Kevin E. Healy, Ph.D.,2,3 and Christine FScleral Reinforcement Through Host Tissue Integration with Biomimetic Enzymatically Degradable Semi-Interpenetrating

Healy, Kevin Edward

344

Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications  

E-Print Network [OSTI]

surgery and 25% die while waiting for a suitable donor. Tissue engineering (TE) has emerged as an alternative to organ transplant; thus, the aim of the present study was to validate a poly(ethylene glycol) diacrylate (PEG-DA) hydrogel system as a model...

Munoz Pinto, Dany 1981-

2012-07-11T23:59:59.000Z

345

Diffusion MRI of Complex Tissue Structure David Solomon Tuch  

E-Print Network [OSTI]

Diffusion MRI of Complex Tissue Structure by David Solomon Tuch B.A., Physics, University Solomon Tuch Submitted to the Division of Health Sciences and Technology on January 11, 2002, in partial to be beyond the scope of diffusion imaging methodology. Thesis Supervisor: Van Jay Wedeen Title: Associate

Duncan, James S.

346

A feasibility study of a gelatin-based tissue substitute  

E-Print Network [OSTI]

experiments was begun in the 1970's by Poston and colleagues at the Oak Ridge National Laboratory (ORNL). During the course of this research many types of detectors and tissue substitutes were used. Early investigations by Garry et al. (1975) used a...

Spence, Jody Lee

1993-01-01T23:59:59.000Z

347

Multivariate classification of infrared spectra of cell and tissue samples  

DOE Patents [OSTI]

Multivariate classification techniques are applied to spectra from cell and tissue samples irradiated with infrared radiation to determine if the samples are normal or abnormal (cancerous). Mid and near infrared radiation can be used for in vivo and in vitro classifications using at least different wavelengths.

Haaland, David M. (Albuquerque, NM); Jones, Howland D. T. (Albuquerque, NM); Thomas, Edward V. (Albuquerque, NM)

1997-01-01T23:59:59.000Z

348

RESEARCH Open Access Tissue inhibitor of metalloproteinase 1 (TIMP-1)  

E-Print Network [OSTI]

induced by carbon tetrachloride (CCl4). Compared with wild-type mice, TIMP-1 knockout mice were moreRESEARCH Open Access Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride- induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

Boyer, Edmond

349

Differentiation of human umbilical cord mesenchymal stem cells into dermal fibroblasts in vitro  

SciTech Connect (OSTI)

Highlights: {yields} Mesenchymal stem cells (MSCs) are potential seed cells for tissue-engineered skin. {yields} Tissue-derived umbilical cord MSCs (UCMSCs) can readily be isolated in vitro. {yields} We induce UCMSCs to differentiate into dermal fibroblasts via conditioned medium. {yields} Collagen type I and collagen type III mRNA level was higher in differentiated cells. {yields} UCMSCs-derived fibroblast-like cells strongly express fibroblast-specific protein. -- Abstract: Tissue-derived umbilical cord mesenchymal stem cells (UCMSCs) can be readily obtained, avoid ethical or moral constraints, and show excellent pluripotency and proliferation potential. UCMSCs are considered to be a promising source of stem cells in regenerative medicine. In this study, we collected newborn umbilical cord tissue under sterile conditions and isolated UCMSCs through a tissue attachment method. UCMSC cell surface markers were examined using flow cytometry. On the third passage, UCMSCs were induced to differentiate into dermal fibroblasts in conditioned induction media. The induction results were detected using immunofluorescence with a fibroblast-specific monoclonal antibody and real time PCR for type I and type III collagen. UCMSCs exhibited a fibroblast-like morphology and reached 90% confluency 14 to 18 days after primary culture. Cultured UCMSCs showed strong positive staining for CD73, CD29, CD44, CD105, and HLA-I, but not CD34, CD45, CD31, or HLA-DR. After differentiation, immunostaining for collagen type I, type III, fibroblast-specific protein, vimentin, and desmin were all strongly positive in induced cells, and staining was weak or negative in non-induced cells; total transcript production of collagen type I and collagen type III mRNA was higher in induced cells than in non-induced cells. These results demonstrate that UCMSCs can be induced to differentiate into fibroblasts with conditioned induction media and, in turn, could be used as seed cells for tissue-engineered dermis.

Han, Yanfu [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China)] [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China); Chai, Jiake, E-mail: cjk304@126.com [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China)] [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China); Sun, Tianjun; Li, Dongjie; Tao, Ran [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China)] [Department of Burn and Plastic Surgery, Burns Institute, First Hospital Affiliated to General Hospital of PLA, Beijing (China)

2011-10-07T23:59:59.000Z

350

Dose profiles through the dermis for on and off-skin hot particle exposures  

E-Print Network [OSTI]

compared to gamma-rays. Gamma-rays are monoenergetic photons with energies ranging from a few keV to several MeV. Unlike beta particles, gamma-rays are indirectly ionizing radiation. Because a gamma-ray is uncharged, it undergoes no direct ionization... detailed data on dose profiles This thesis follows the format of Radiation Protection Dosimetry. through the dermis from fuel fragments or from mixed beta-gamma activation products. The effects of beta-emitting hot particles suspended above skin without...

Shaw, Kimberly Rochelle

1993-01-01T23:59:59.000Z

351

Constraining the symmetry energy from the neutron skin thickness of Tin isotopes  

E-Print Network [OSTI]

We show in the Skyrme-Hartree-Fock approach that unambiguous correlations exist between observables of finite nuclei and nuclear matter properties. Using this correlation analysis to existing data on the neutron skin thickness of Sn isotopes, we find important constraints on the value E_{sym}(rho_0) and density slope L of the nuclear symmetry energy at saturation density. Combining these constraints with those from recent analyses of isospin diffusion and double neutron/proton ratio in heavy ion collisions leads to a value of L=58\\pm 18 MeV approximately independent of E_{sym}(\\rho_0).

Lie-Wen Chen; Che Ming Ko; Jun Xu; Bao-An Li

2011-03-24T23:59:59.000Z

352

Constraints on neutron skin thickness in 208Pb and density-dependent symmetry energy  

E-Print Network [OSTI]

Accurate knowledge about the neutron skin thickness $\\Delta R_{np}$ in $^{208}$Pb has far-reaching implications for different communities of nuclear physics and astrophysics. Yet, the novel Lead Radius Experiment (PREX) did not yield stringent constraint on the $\\Delta R_{np}$ recently. We employ a more practicable strategy currently to probe the neutron skin thickness of $^{208}$Pb based on a high linear correlation between the $\\Delta R_{np}$ and $J-a_{\\text{sym}}$, where $J$ and $a_{\\text{sym}}$ are the symmetry energy (coefficient) of nuclear matter at saturation density and of $^{208}$Pb. An accurate $J-a_{\\text{sym}}$ thus places a strong constraint on the $\\Delta R_{np}$. Compared with the parity-violating asymmetry $A_{\\text{PV}}$ in the PREX, the reliably experimental information on the $J-a_{\\text{sym}}$ is much more easily available attributed to a wealth of measured data on nuclear masses and on decay energies. The density dependence of the symmetry energy is also well constrained with the $J-a_{\\...

Dong, Jianmin; Gu, Jianzhong

2015-01-01T23:59:59.000Z

353

On the fracture of human dentin: Is it stress-or strain-controlled?  

E-Print Network [OSTI]

On the fracture of human dentin: Is it stress- or strain-controlled? R. K. Nalla,1 J. H. Kinney,2 R information in archival literature that can be usefully used to model such fracture. In fact, although the fracture event in dentin, akin to other mineralized tissues like bone, is widely believed to be locally

Ritchie, Robert

354

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery  

E-Print Network [OSTI]

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c understood, roles in copper delivery to cytochrome c oxidase (COX). Mutations in these genes pro- duce tissue copper delivery pathway in SCO1 and SCO2 patient backgrounds. Immunoblot analysis of patient cell lines

Shoubridge, Eric

355

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model  

E-Print Network [OSTI]

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model K. Lu,1 J. W autoregulation, brain gas ex- change, and their interaction by means of a mathematical model. We have previously of intracranial dynamics. However, their models did not include gas transport in brain tissue and thus can

356

Final Report for completed IPP Project:"Development of Plasma Ablation for Soft Tissue and Bone Surgery"  

SciTech Connect (OSTI)

ArthroCare is a medical device company that develops, manufactures, and markets an advanced surgical tool, a plasma electro-surgical system for cutting and removing tissue. The hand-held electrical discharge device produces plasma in a biocompatible conductive fluid and tissue to which it is applied during surgery. Its products allow surgeons to operate with increased precision and accuracy, limiting damage to surrounding tissue thereby reducing pain and speeding recovery for the patient. In the past, the design of ArthfoCare's plasma wands has been an empirical undertaking. One goal of this R&D program was to put the phenomena involved on a sound scientific footing, allowing optimization of existing plasma based electro-surgery system technology, and the design and manufacture of new and improved kinds of scalpels, in particular for the surgical cutting of bone. Another important related goal of the program was to develop, through an experimental approach, new plasma wand approaches to the cutting ('shaving') of hard bone tissue. The goals of the CRADA were accomplished - computer models were used to predict important parameters of the plasma discharge and the bone environment, and several different approaches to bone-shaving were developed and demonstrated. The primary goal of the project was to develop and demonstrate an atmospheric-pressure plasma tool that is suitable for surgical use for shaving bone in humans. This goal was accomplished, in fact with several different alternative plasma approaches. High bone ablation speeds were measured. The use of probes ('plasma wand' - the surgical tool) with moving active electrodes was also explored, and there are advantages to this method. Another important feature is that the newly-exposed bone surface have only a very thin necrosis layer; this feature was demonstrated. This CRADA has greatly advanced our understanding of bone removal by atmospheric pressure plasmas in liquid, and puts ArthroCare in a good position to develop the techniques for commercial (surgical) application.

Brown, Ian

2009-09-01T23:59:59.000Z

357

Skin cancer in albinos at the University of Calabar Teaching Hospital, Calabar, Nigeria  

E-Print Network [OSTI]

of the human P gene in tyrosinase positive oculocutaneousJenkins T, Ramsay M. The tyrosinase positive oculocutaneousrecessive forms involves the tyrosinase gene (OCA1), whereas

Asuquo, M E; Otei, O O; Omotoso, J; Bassey, E E

2010-01-01T23:59:59.000Z

358

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

2000-05-15T23:59:59.000Z

359

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

2007-12-20T23:59:59.000Z

360

STUDENT EMPLOYMENT HUMAN RESOURCES  

E-Print Network [OSTI]

STUDENT EMPLOYMENT HUMAN RESOURCES GUIDELINE Human Resources | One Washington Square | San José, CA 95192-0046 | 408-924-2250 408-924-2284 (fax) SUBJECT: STUDENT EMPLOYMENT DATE: March 2007 I. PURPOSE / DESCRIPTION Student employees are defined as matriculated students that work part-time in any

Gleixner, Stacy

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

362

HUMAN BRAIN IMAGING AT 9.4 TESLA USING A COMBINATION OF TRAVELING WAVE EXCITATION WITH A 15-CHANNEL RECEIVE-ONLY ARRAY  

E-Print Network [OSTI]

HUMAN BRAIN IMAGING AT 9.4 TESLA USING A COMBINATION OF TRAVELING WAVE EXCITATION WITH A 15-CHANNEL is a successful setup for routine human brain imaging at 7 Tesla. For reception, the use of multiple surface coils multichannel transmit coils. At 9.4 Tesla, however, the even shorter RF wavelength in tissue causes the B1

363

Method of tissue repair using a composite material  

DOE Patents [OSTI]

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

2014-03-18T23:59:59.000Z

364

A two level finite difference scheme for one dimensional Pennes bioheat equation  

E-Print Network [OSTI]

tissues [2,4,9]. Furthermore, skin burns caused by exposing human body to heat in a flash fire or being unconditionally. Numerical experiments for a skin-heating model are conducted. Ă? 2005 Elsevier Inc. All rights, by the U.S. Department of Energy Office of Science under grant DE-FG02-02ER45961, by the Japanese Research

Zhang, Jun

365

Collagen-Hyaluronic Acid Scaffolds for Adipose Tissue Engineering  

E-Print Network [OSTI]

-drying, also known as lyophilization, is commonly employed to produce water-soluble polymer scaffolds such as collagen [12, 41-43]. In this technique, a suspension of the water-soluble polymer is frozen, thereby forming an interpenetrating network of ice... . Keywords: Collagen; crosslinking; freeze-drying; hyaluronic acid; scaffolds, adipose tissue engineering 1. Introduction The mammary gland comprises a complex branched epithelial network invested within an adipocyte-rich stroma termed a fat...

Davidenko, Natalia; Campbell, J. J.; Thian, E. S.; Watson, C. J,; Cameron, Ruth Elizabeth

2010-01-01T23:59:59.000Z

366

Photoacoustic computed tomography in biological tissues: algorithms and breast imaging  

E-Print Network [OSTI]

are investigated in Chapter III and IV, respectively. Finally, a prototype of an RF-induced PA imaging system is introduced and experiments using phantom samples as well as a preliminary study of breast imaging for cancer detection are reported in Chapter V... PHOTOACOUSTIC COMPUTED TOMOGRAPHY IN BIOLOGICAL TISSUES: ALGORITHMS AND BREAST IMAGING A Dissertation by MINGHUA XU Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements...

Xu, Minghua

2004-11-15T23:59:59.000Z

367

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry  

SciTech Connect (OSTI)

We present the first results showing the ambient imaging of biological samples in their native environment using nanospray desorption ionization (nanoDESI) mass spectrometry. NanoDESI is an ambient pressure ionization technique that enables precise control of ionization of molecules from substrates. We demonstrate highly sensitive and robust analysis of tissue samples with high spatial resolution (<12 {mu}m) without sample preparation, which will be essential for applications in clinical diagnostics, drug discovery, molecular biology, and biochemistry.

Laskin, Julia; Heath, Brandi S.; Roach, Patrick J.; Cazares, Lisa H.; Semmes, O. John

2012-01-03T23:59:59.000Z

368

Beliefs about Human Extinction  

SciTech Connect (OSTI)

This paper presents the results of a web-based survey about futures issues. Among many questions, respondents were asked whether they believe humans will become extinct. Forty-five percent of the almost 600 respondents believe that humans will become extinct. Many of those holding this believe felt that humans could become extinct within 500-1000 years. Others estimated extinction 5000 or more years into the future. A logistic regression model was estimated to explore the bases for this belief. It was found that people who describe themselves a secular are more likely to hold this belief than people who describe themselves as being Protestant. Older respondents and those who believe that humans have little control over their future also hold this belief. In addition, people who are more apt to think about the future and are better able to imagine potential futures tend to also believe that humans will become extinct.

Tonn, Bruce Edward [ORNL

2009-11-01T23:59:59.000Z

369

DDT residues in human milk samples from Delhi, India  

SciTech Connect (OSTI)

The widespread use of DDT in India has resulted in increased levels of the insecticide in the ecosystem and, therefore, the potential possible health hazards has been voiced. DDT-residues excreted in milk have been reported from different parts of the world; however, very few reports did appear from India. In fact, there is no report on DDT-content in human milk from Delhi area where higher levels of DDT and BHC in human adipose tissues and blood have already been reported. Higher bioaccumulation of DDT might reflect the higher excretion of residues in milk. The authors have, therefore, attempted a systematic study to monitor DDT-residues in human milk samples collected from various hospitals of Delhi (India).

Zaidi, S.S.A.; Bhatnagar, V.K.; Banerjee, B.D.; Balakrishnan, G.; Shah, M.P.

1989-03-01T23:59:59.000Z

370

ISSUE 1 | SPRING 2014 BRINGING CUTTING-EDGE SCIENCE INTO THE CLASSROOM UNDER YOUR SKIN  

E-Print Network [OSTI]

more resources at www. wellcome.ac.uk/bigpicture/ proteins. inSide PROBING PROTEINS A numerical look to www.wellcome.ac.uk/bigpicture/ proteins for more teaching resources, including extra articles, useful. Mitochondrion Human egg Globular protein Uk argentina Bangladesh in human proteins are essential

Rambaut, Andrew

371

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources  

E-Print Network [OSTI]

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources VOLUNTARY WORKLOAD/or Spring ____ Quarter(s) Funding Source: ________________________________________ (Salary adjustments

California at Santa Cruz, University of

372

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada  

E-Print Network [OSTI]

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada 1) Permits be obtained from the Public Health Agency Canada (PHAC) to facilitate customs clearance. 2) If a permit

373

Division of Human Resources Human Resources / Attendance and Leave Philosophy  

E-Print Network [OSTI]

Division of Human Resources PHILOSOPHY Human Resources / Attendance and Leave Philosophy Form Leave Act (FMLA). USF augments these provisions with local processes and philosophies and, in some cases

Meyers, Steven D.

374

Proc. 3rd International Conference on Networked Sensing Systems (INSS 2006), pp. 55-60, Rosemont, Illinois (USA), May, 2006. A Whole Body Artificial Skin  

E-Print Network [OSTI]

are required to be more cautious about surrounding environments than robots in industrial factories because a tactile sensor skin as one of applications of the system. In this application, the cells are not only within its sensing area. The resulting robot skin is soft, stretchable, and able to cover a large area

Shinoda, Hiroyuki

375

Associate Vice President Human Resources  

E-Print Network [OSTI]

Associate Vice President Human Resources Enjoy Athens! Great schools Affordable housing Eclectic Vice President for Human Resources. This position reports directly to the Vice President for Finance and Administration and provides leadership for the University's human resources programs and services

Arnold, Jonathan

376

Human Resources Simon Fraser University  

E-Print Network [OSTI]

Human Resources Simon Fraser University Administrative and Professional Staff Job Description A. Identification Position Number: 31482 Position Title: Administrative Assistant (Human Resources Liaison) Name guidance, direction, coordination and effective management and implementation of SFU's Human Resources

Kavanagh, Karen L.

377

Special Issue on Human Computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Nijholt, Anton

378

The human genome project  

SciTech Connect (OSTI)

The Human Genome Project will obtain high-resolution genetic and physical maps of each human chromosome and, somewhat later, of the complete nucleotide sequence of the deoxyribonucleic acid (DNA) in a human cell. The talk will begin with an extended introduction to explain the Project to nonbiologists and to show that map construction and sequence determination require extensive computation in order to determine the correct order of the mapped entities and to provide estimates of uncertainty. Computational analysis of the sequence data will become an increasingly important part of the project, and some computational challenges are described. 5 refs.

Bell, G.I.

1991-06-01T23:59:59.000Z

379

Effect of temperature on the effective mass and the neutron skin of nuclei  

E-Print Network [OSTI]

We study the finite temperature Hartree-Fock-BCS approximation for selected stable Sn nuclei with zero-range Skyrme forces. Hartree Fock BCS approximation allows for a straightforward interpretation of the results since it involves u and v's which are not matrices as in HFB. Pairing transitions from superfluid to the normal state are studied with respect to the temperature. The temperature dependence of the nuclear radii and neutron skin are also analyzed. An increase of proton and neutron radii is obtained in neutron rich nuclei especially above the critical temperature. Using different Skyrme energy functionals, it is found that the correlation between the effective mass in symmetric nuclear matter and the critical temperature depends on the pairing prescription. The temperature dependence of the nucleon effective mass is also investigated, showing that proton and neutron effective masses display different behavior below and above the critical temperature, due to the small temperature dependence of the density.

E. Yüksel; E. Khan; K. Bozkurt; G. Colň

2014-10-31T23:59:59.000Z

380

The neutron skin in neutron-rich nuclei at Jefferson Lab  

SciTech Connect (OSTI)

The Jefferson Lab program to measure the symmetry energy of neutron-rich nuclear matter, using precision electroweak methods, is progressing well. The initial measurement by the PREX experiment, leading to a 2-sigma determination of the 'neutron skin' in {sup 208}Pb, has been published. Design and preparation for a further, more-precise measurement on {sup 208}Pb is progressing well and there is general acceptance of the great advantage to a further measurement on {sup 48}Ca. The surprising ancillary result that the beam-normal single-spin asymmetry for {sup 208}Pb is consistent with zero is also now in the literature. This paper will discuss the current experimental situation of the program.

Dalton, Mark M. [University of Virginia (United States)

2013-11-07T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Neutron-skin thickness from the study of the anti-analog giant dipole resonance  

SciTech Connect (OSTI)

The {gamma}-decay of the anti-analog of the giant dipole resonance (AGDR) to the isobaric analog state has been measured following the p({sup 124}Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent relativistic random-phase approximation (RPA) and turned out to be very sensitive to the neutronskin thickness ({Delta}R{sub pn}). By comparing the theoretical results with the measured one, the {Delta}R{sub pn} value for {sup 124}Sn was deduced to be 0.21 {+-} 0.07 fm, which agrees well with the previous results. The present method offers new possibilities for measuring the neutron-skin thicknesses of very exotic isotopes.

Krasznahorkay, A.; Stuhl, L.; Csatlos, M.; Algora, A. [Inst. of Nucl. Res. of the Hungarian Acad. of Sci. (ATOMKI), H-4001 Debrecen, P.O. Box 51 (Hungary); Physics Department, Faculty of Science, University of Zagreb (Croatia); Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); and others

2012-10-20T23:59:59.000Z

382

Method of forming a continuous polymeric skin on a cellular foam material  

DOE Patents [OSTI]

Hydrophobic cellular material is coated with a thin hydrophilic polymer skin which stretches tightly over the outer surface of the foam but which does not fill the cells of the foam, thus resulting in a polymer-coated foam structure having a smoothness which was not possible in the prior art. In particular, when the hydrophobic cellular material is a specially chosen hydrophobic polymer foam and is formed into arbitrarily chosen shapes prior to the coating with hydrophilic polymer, inertial confinement fusion (ICF) targets of arbitrary shapes can be produced by subsequently coating the shapes with metal or with any other suitable material. New articles of manufacture are produced, including improved ICF targets, improved integrated circuits, and improved solar reflectors and solar collectors. In the coating method, the cell size of the hydrophobic cellular material, the viscosity of the polymer solution used to coat, and the surface tensin of the polymer solution used to coat are all very important to the coating.

Duchane, David V. (Los Alamos, NM); Barthell, Barry L. (Los Alamos, NM)

1985-01-01T23:59:59.000Z

383

Acquisition and reconstruction of brain tissue using knife-edge scanning microscopy  

E-Print Network [OSTI]

....................................................................................38 VII RESULTS..................................................................................................................40 A. Scanning of Golgi Stained Tissue and Alignment ...........................................40 B.... Scanning and Reconstruction of Nissl Stained Tissue .....................................43 VIII SUMMARY AND FUTURE WORK.......................................................................46 A. Summary...

Mayerich, David Matthew

2004-09-30T23:59:59.000Z

384

Modeling Frameworks for Representing the Mechanical Behavior of Tissues with a Specific Look at Vasculature  

E-Print Network [OSTI]

Many mechanicstic models aimed at predicting tissue behavior attempt to connect constitutive factors (such as effects due to collagen or fibrin concentrations) with the overall tissue behavior. Such a link between constitutive and material behaviors...

Andersohn, Alexander

2013-08-27T23:59:59.000Z

385

Polymer-tethered epidermal growth factor as an inductive biomaterial surface for connective tissue progenitors  

E-Print Network [OSTI]

Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most ...

Fan, Vivian H. (Vivian Hanbing)

2006-01-01T23:59:59.000Z

386

T2*-weighted magnetic resonance imaging used to detect coagulative necrosis in tissue  

E-Print Network [OSTI]

to prevent unnecessary collateral damage to surrounding healthy tissue. This research focuses on using T2*-weighted FLASH magnetic resonance imaging to detect irreversible changes in i . n vitro bovine liver tissue and tissuesimulating polyacrylamide gel...

Van Hyfte, John Bruce

1997-01-01T23:59:59.000Z

387

E-Print Network 3.0 - adipose white tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

white tissue Search Powered by Explorit Topic List Advanced Search Sample search results for: adipose white tissue Page: << < 1 2 3 4 5 > >> 1 original article The new engl and...

388

E-Print Network 3.0 - adipose tissue heart Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adipose tissue heart Page: << < 1 2 3 4 5 > >> 1 Microlymphatic and tissue oxygen tension in...

389

E-Print Network 3.0 - avian brain tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain tissue Search Powered by Explorit Topic List Advanced Search Sample search results for: avian brain tissue Page: << < 1 2 3 4 5 > >> 1 60 Wader Study Group Bulletin 115 (1)...

390

Application of magnetic resonance microscopy to tissue engineering: A polylactide model  

E-Print Network [OSTI]

Application of magnetic resonance microscopy to tissue engineering: A polylactide model K. J. L seeding; magnetic resonance mi- croscopy; polylactide; tissue engineering INTRODUCTION Absorbable polymers Engineering Research Center, Clemson University, Clemson, South Carolina 29634-0905 2 Department of Radiology

391

An energy-preserving muscle tissue model: formulation and compatible discretizations  

E-Print Network [OSTI]

An energy-preserving muscle tissue model: formulation and compatible discretizations D. Chapelle ­ phenomena associated with these energy considerations. Keywords: muscle tissue modeling; myocardium; multiscale; energy balance; time and space discretizations 1 Introduction The modeling of the active

Paris-Sud XI, Université de

392

Ice-templated structures for biomedical tissue repair: From physics to final scaffolds  

E-Print Network [OSTI]

temperature and solutes. The porous structures created using ice-templating allow scaffolds to be used for many diverse applications, from microfluidics to biomedical tissue engineering. Within the field of tissue engineering, scaffold structure can influence...

Pawelec, K. M.; Husmann, A; Best, Serena Michelle; Cameron, Ruth Elizabeth

2014-04-11T23:59:59.000Z

393

Tissue spectroscopic characterization based on fluorescence, second harmonic generation, and reflected light  

E-Print Network [OSTI]

The diagnosis of many diseases often requires a histological analysis of tissues. Histology analysis compares the microscopic structure of a tissue specimen with an image database containing known physiological and ...

Laiho, Lily H., 1973-

2004-01-01T23:59:59.000Z

394

The uptake, tissue distribution and depuration of a polychlorinated naphthalene (Halowax 1099) in relation to tissue lipid levels in the American oyster Crassostrea virginica  

E-Print Network [OSTI]

& mantle & riiuscle, while those pre- viously exposed to 60 ppb were visceral mass & mantle & gill & muscle. The exchange in order between gill and mantle tissues under maximum uptake and depuration conditions probably indicates their similarity rather...THE UPTAKE, TISSUE DISTRIBUTION AND DEPURATION OF A POLYCHLORINATED NAPHTHALENE (HALOWAX 1099) IN RELATION TO TISSUE LIPID LEVELS IN THE AMERICAN OYSTER CRASSOSTREA VIRGINICA A Thesis by WILLIAM JAMES RUE, JR. Submitted to the Graduate...

Rue, William James

1979-01-01T23:59:59.000Z

395

E-Print Network 3.0 - acl tissue engineering Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

tissue engineering efforts... based functional ... Source: Lu, Helen H. - Department of Biomedical Engineering, Columbia University Collection: Biology and Medicine ; Engineering...

396

E-Print Network 3.0 - adipose tissue status Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Insulin Sensitivity... insulin resistance. Obese adipose tissue displays ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

397

E-Print Network 3.0 - adipose tissue liver Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

controls fatty acid and glucose homeostasis Summary: ; liver steatosis ; insulin secretion Introduction White adipose tissue (WAT) homeostasis implicates... . When adipose...

398

Landau damping and anomalous skin effect in low-pressure gas discharges: Self-consistent treatment of collisionless heatinga...  

E-Print Network [OSTI]

for calculation of the non-Maxwellian EEDF. This system was applied to the calculation of collisionless heating electric field anomalous skin effect . Also for inhomogeneous electric fields another mechanism of heating density profile and a Maxwellian EEDF. In the present study a self-consistent system of equations

Kaganovich, Igor

399

Proper Setup of HVAC System in Conjunction with Sound Building 'Skin' Design for Alleviation of IAQ and Energy Performance Problems  

E-Print Network [OSTI]

climates, not only because of the loss of energy, but also because of damage that can result to insulation, drywall, and structure in addition to promotion of mold and mildew growth. Proper setup of the HVAC system, in conjunction with sound building “skin...

Rosenberg, M.

2006-01-01T23:59:59.000Z

400

Surgical technique, using skin, for repair of simultaneously ruptured anterior cruciate and medial collateral ligaments of the canine femorotibial articulation  

E-Print Network [OSTI]

Agricultural and Mechanical College of Texan In Partial Fulfillnent of the !Iequireaents for the Degree Meeter of Science in Veterinary Medicine and Surgery by Janie Neal Chaetain January 1&359 SURGICAL TECHNI((UE ~ USIN'G SKIN ~ FOR REPAIR...

Chastain, Jamie Neal

1959-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Viscoelastic Analysis of Sandwich Beams Having Aluminum and Fiber-reinforced Polymer Skins with a Polystyrene Foam Core  

E-Print Network [OSTI]

Sandwich beams are composite systems having high stiffness-to-weight and strength-to-weight ratios and are used as light weight load bearing components. The use of thin, strong skin sheets adhered to thicker, lightweight core materials has allowed...

Roberts-Tompkins, Altramese L.

2010-07-14T23:59:59.000Z

402

Human Reliability | ornl.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Reliability SHARE Human Reliability The Structured Trusted Employee Program (STEP) Evaluation is an example of a method for identifying, assessing, and retaining reliable and...

403

Human Reliability Program Overview  

SciTech Connect (OSTI)

This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

Bodin, Michael

2012-09-25T23:59:59.000Z

404

KRFTWRK – Global Human Electricity  

E-Print Network [OSTI]

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

405

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

2007-12-20T23:59:59.000Z

406

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

2000-05-15T23:59:59.000Z

407

Human Resource Management Delegation  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

1996-06-28T23:59:59.000Z

408

TEMPORARY SUPPORT HUMAN RESOURCES  

E-Print Network [OSTI]

TEMPORARY SUPPORT HUMAN RESOURCES GUIDELINE Workforce Planning | One Washington Square | San José of the Request for Temporary Support, Workforce Planning will make a determination of the type of temporary

Su, Xiao

409

Molecular cloning and localization of the human GAX gene to 7p21  

SciTech Connect (OSTI)

The GAX homeobox gene is expressed in the cardiovascular tissues of the adult rat, including heart, lung, kidney, and blood vessels. In the vasculature it is specifically expressed in quiescent smooth muscle cells, but its expression is rapidly down-regulated when these cells are stimulated to proliferate with mitogens. Since vascular smooth muscle cell proliferation is important in the pathology of blood vessel disorders, the human GAX gene was isolated and characterized. The human GAX cDNA was obtained by an anchored-PCR approach using cDNA templates from cardiovascular tissues and amplification primers designed from sequence information of the rat GAK cDNA and the homeodomain-containing exon of the human GAX gene. The human and rat GAX gene coding sequences are 98% conserved at the amino acid level and 83% conserved at the nucleotide level. Similar to rat, the human homolog contains a CAX trinucleotide repeat N-terminal to the homeodomain that encodes for a stretch of 17 consecutive histidine or glutamine residues. The human GAX locus was mapped by fluorescence in situ hybridization to the short arm of chromosome 7 at band p21. The human cDNA sequence will be useful for analyses of GAX gene expression in cardiovascular diseases. 30 refs., 3 figs., 1 tab.

LePage, D.F. [Case Western Reserve Univ., Cleveland, OH (United States)] [Case Western Reserve Univ., Cleveland, OH (United States); Altomare, D.A.; Testa, J.R. [Fox Chase Cancer Center, Philadelphia, PA (United States)] [and others] [Fox Chase Cancer Center, Philadelphia, PA (United States); and others

1994-12-01T23:59:59.000Z

410

LIVER BIOLOGY AND PATHOBIOLOGY Liver Tissue Engineering at Extrahepatic Sites in Mice  

E-Print Network [OSTI]

LIVER BIOLOGY AND PATHOBIOLOGY BIOLOGY Liver Tissue Engineering at Extrahepatic Sites in Mice indicate that liver tissues can be engineered and maintained at extrahepatic sites, retain their capacity and Mark A. Kay1 Liver tissue engineering using hepatocyte transplantation has been proposed as an alterna

Kay, Mark A.

411

Changes in the Mechanical and Biochemical Properties of Aortic Tissue due to Cold Storage  

E-Print Network [OSTI]

Changes in the Mechanical and Biochemical Properties of Aortic Tissue due to Cold Storage Ming Background. Temporary cold storage is a common procedure for preserving tissues for a short time be- fore; collagen; mechan- ical properties; arteries; cold storage; soft tissue; mechanical testing; vascular

Zhang, Katherine Yanhang

412

Mise en vidence d'une activit lipoprotine-lipasique dans le tissu adipeux de chvre  

E-Print Network [OSTI]

partir de poudres acéto- #12;niques (Korn et Quigley, 1955) puis acéto-éthérées du tissu (Robinson, 1963'homogénats aqueux du tissu adipeux (Korn et Quigley, 1955). D'après Benson (1969), la L.P.L. du tissu adipeux de

Boyer, Edmond

413

Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds  

E-Print Network [OSTI]

in the aerospace and automotive industries due to the high strength 187 to weight ratios the fibers can provide when combined with conventional materials [54]. 188 Reviewed here are composites combining nano- or micro-fibers with hydrogels for tissue 189... laminate was 289 created using layers of electrospun poly(l-lactide) (PLA) fibers with a poly(lactide-co-290 ethylene oxide fumarate) (PLEOF) hydrogel, which was tested using DMA at 37 şC. The 291 13 modulus of the composite when wet was 575 ± 14 MPa...

Butcher, Annabel L.; Offeddu, Giovanni S.; Oyen, Michelle L.

2014-10-04T23:59:59.000Z

414

The recognition of certain parasitic worms in tissue sections  

E-Print Network [OSTI]

4o be seen in tissue sections, The parts sms4 lihsly to be seen are Chs outicle, subcuticley muscles, body cavity, digestive tract, and genital organs, Therefore, emphasis is placed on these anatomioal perte, uith Che ezcsption of the genital... this terminology 2 ~ 10 6 and point out that "the outex most oellular layer is not in direct relation with Che environment bu4 is covered by a cuCiols and is there fore termed Chs hypodermis?u The suboutiole in most species, 'but not in all ~ has four...

Payne, Bobby Joe

2012-06-07T23:59:59.000Z

415

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

SciTech Connect (OSTI)

Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture. In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function ahead of the crack tip, such as plasticity in metals, and extrinsic mechanisms which function primarily behind the tip, such as crack bridging in ceramics. Bone and dentin derive their resistance to fracture principally from extrinsic toughening mechanisms which have their origins in the hierarchical microstructure of these mineralized tissues. Experimentally, quantification of these toughening mechanisms requires a crack-growth resistance approach, which can be achieved by measuring the crack-driving force, e.g., the stress intensity, as a function of crack extension ("R-curve approach"). Here this methodology is used to study of the effect of aging on the fracture properties of human cortical bone and human dentin in order to discern the microstructural origins of toughness in these materials.

Ager, Joel; Koester, Kurt J.; Ager III, Joel W.; Ritchie, Robert O.

2008-05-07T23:59:59.000Z

416

Developing Human Performance Measures  

SciTech Connect (OSTI)

Through the reactor oversight process (ROP), the U.S. Nuclear Regulatory Commission (NRC) monitors the performance of utilities licensed to operate nuclear power plants. The process is designed to assure public health and safety by providing reasonable assurance that licensees are meeting the cornerstones of safety and designated crosscutting elements. The reactor inspection program, together with performance indicators (PIs), and enforcement activities form the basis for the NRC’s risk-informed, performance based regulatory framework. While human performance is a key component in the safe operation of nuclear power plants and is a designated cross-cutting element of the ROP, there is currently no direct inspection or performance indicator for assessing human performance. Rather, when human performance is identified as a substantive cross cutting element in any 1 of 3 categories (resources, organizational or personnel), it is then evaluated for common themes to determine if follow-up actions are warranted. However, variability in human performance occurs from day to day, across activities that vary in complexity, and workgroups, contributing to the uncertainty in the outcomes of performance. While some variability in human performance may be random, much of the variability may be attributed to factors that are not currently assessed. There is a need to identify and assess aspects of human performance that relate to plant safety and to develop measures that can be used to successfully assure licensee performance and indicate when additional investigation may be required. This paper presents research that establishes a technical basis for developing human performance measures. In particular, we discuss: 1) how historical data already gives some indication of connection between human performance and overall plant performance, 2) how industry led efforts to measure and model human performance and organizational factors could serve as a data source and basis for a framework, 3) how our use of modeling and simulation techniques could be used to develop and validate measures of human performance, and 4) what the possible outcomes are from this research as the modeling and simulation efforts generate results.

Jeffrey Joe; Bruce Hallbert; Larry Blackwood; Donald Dudehoeffer; Kent Hansen

2006-05-01T23:59:59.000Z

417

Use of proton beams with breast prostheses and tissue expanders  

SciTech Connect (OSTI)

Since the early 2000s, a small but rapidly increasing number of patients with breast cancer have been treated with proton beams. Some of these patients have had breast prostheses or tissue expanders in place during their courses of treatment. Procedures must be implemented to plan the treatments of these patients. The density, kilovoltage x-ray computed tomography numbers (kVXCTNs), and proton relative linear stopping powers (pRLSPs) were calculated and measured for several test sample devices. The calculated and measured kVXCTNs of saline were 1% and 2.4% higher than the values for distilled water while the calculated RLSP for saline was within 0.2% of the value for distilled water. The measured kVXCTN and pRLSP of the silicone filling material for the test samples were approximately 1120 and 0.935, respectively. The conversion of kVXCTNs to pRLSPs by the treatment planning system standard tissue conversion function is adequate for saline-filled devices but for silicone-filled devices manual reassignment of the pRLSPs is required.

Moyers, Michael F., E-mail: MFMoyers@roadrunner.com [ProCure Proton Therapy Center, Somerset, NJ (United States); Mah, Dennis; Boyer, Sean P.; Chang, Chang [ProCure Proton Therapy Center, Somerset, NJ (United States); Pankuch, Mark [ProCure Proton Therapy Center, Warrenville, IL (United States)

2014-04-01T23:59:59.000Z

418

Regulation of biological tissue mineralization through post-nucleation shielding  

E-Print Network [OSTI]

In vertebrates, insufficient availability of calcium and phosphate ions in extracellular fluids leads to loss of bone density and neuronal hyper-excitability. To counteract this problem, calcium ions are present at high concentrations throughout body fluids -- at concentrations exceeding the saturation point. This condition leads to the opposite situation where unwanted mineral sedimentation may occur. Remarkably, ectopic or out-of-place sedimentation into soft tissues is rare, in spite of the thermodynamic driving factors. This fortunate fact is due to the presence of auto-regulatory proteins that are found in abundance in bodily fluids. Yet, many important inflammatory disorders such as atherosclerosis and osteoarthritis are associated with this undesired calcification. Hence, it is important to gain an understanding of the regulatory process and the conditions under which it can go awry. In this Letter, we use ideas from mean-field classical nucleation theory to study the regulation of sedimentation of calcium phosphate salts in biological tissues through the mechanism of post-nuclear shielding of nascent mineral particles by binding proteins. A critical concentration of regulatory protein is identified as a function of the physical parameters that describe the system.

Joshua C. Chang; Robert M. Miura

2015-01-29T23:59:59.000Z

419

Time, Humans and Societal Challenges  

E-Print Network [OSTI]

,000 (human development) Since 1850 (industrial revolution Since 1950 (population explosion) Sustainable

420

Stanford University IRB Guidance On Data and Tissue Repositories  

E-Print Network [OSTI]

of outcomes information complied for quality assurance activities · A list of potential research subjects Page of these resources is governed by both the federal human subject protection regulations (Common Rule and DHHS regulations) at 45 CFR 46 and the federal privacy rule regulations (HIPAA) at 45 CRF 160 & 164. Specific

Puglisi, Joseph

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to obtain the most current and comprehensive results.


421

Human hybrid hybridoma  

SciTech Connect (OSTI)

Hybrid hybridomas are obtained by fusion of two cells, each producing its own antibody. Several authors have reported the construction of murine hybrid hybridomas with the aim to obtain bispecific monoclonal antibodies. The authors have investigated, in a model system, the feasibility of constructing a human hybrid hybridoma. They fused two monoclonal cell lines: an ouabain-sensitive and azaserine/hypoxanthine-resistant Epstein-Barr virus-transformed human cell line that produces an IgG1kappa antibody directed against tetanus toxiod and an azaserine/hypoxanthine-sensitive and ouabain-resistant human-mouse xenohybrid cell line that produces a human IgG1lambda antibody directed against hepatitis-B surface antigen. Hybrid hybridoma cells were selected in culture medium containing azaserine/hypoxanthine and ouabain. The hybrid nature of the secreted antibodies was analyzed by means of two antigen-specific immunoassay. The results show that it is possible, with the combined use of transformation and xenohybridization techniques, to construct human hybrid hybridomas that produce bispecific antibodies. Bispecific antibodies activity was measured by means of two radioimmunoassays.

Tiebout, R.F.; van Boxtel-Oosterhof, F.; Stricker, E.A.M.; Zeijlemaker, W.P.

1987-11-15T23:59:59.000Z

422

Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic  

SciTech Connect (OSTI)

Chronic arsenic (As) exposure affects the endothelial system causing several diseases. Big endothelin-1 (Big ET-1), the biological precursor of endothelin-1 (ET-1) is a more accurate indicator of the degree of activation of the endothelial system. Effect of As exposure on the plasma Big ET-1 levels and its physiological implications have not yet been documented. We evaluated plasma Big ET-1 levels and their relation to hypertension and skin lesions in As exposed individuals in Bangladesh. A total of 304 study subjects from the As-endemic and non-endemic areas in Bangladesh were recruited for this study. As concentrations in water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The plasma Big ET-1 levels were measured using a one-step sandwich enzyme immunoassay kit. Significant increase in Big ET-1 levels were observed with the increasing concentrations of As in drinking water, hair and nails. Further, before and after adjusting with different covariates, plasma Big ET-1 levels were found to be significantly associated with the water, hair and nail As concentrations of the study subjects. Big ET-1 levels were also higher in the higher exposure groups compared to the lowest (reference) group. Interestingly, we observed that Big ET-1 levels were significantly higher in the hypertensive and skin lesion groups compared to the normotensive and without skin lesion counterpart, respectively of the study subjects in As-endemic areas. Thus, this study demonstrated a novel dose–response relationship between As exposure and plasma Big ET-1 levels indicating the possible involvement of plasma Big ET-1 levels in As-induced hypertension and skin lesions. -- Highlights: ? Plasma Big ET-1 is an indicator of endothelial damage. ? Plasma Big ET-1 level increases dose-dependently in arsenic exposed individuals. ? Study subjects in arsenic-endemic areas with hypertension have elevated Big ET-1 levels. ? Study subjects with arsenic-induced skin lesions show elevated plasma Big ET-1 levels. ? Arsenic-induced hypertension and skin lesions may be linked to plasma Big ET-1 levels.

Hossain, Ekhtear; Islam, Khairul; Yeasmin, Fouzia [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh); Karim, Md. Rezaul [Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003 (Bangladesh)] [Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003 (Bangladesh); Rahman, Mashiur; Agarwal, Smita; Hossain, Shakhawoat; Aziz, Abdul; Al Mamun, Abdullah; Sheikh, Afzal; Haque, Abedul; Hossain, M. Tofazzal [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh); Hossain, Mostaque [Department of Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka (Bangladesh)] [Department of Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka (Bangladesh); Haris, Parvez I. [Faculty of Health and Life Sciences, De Montfort University, Leicester, LE1 9BH (United Kingdom)] [Faculty of Health and Life Sciences, De Montfort University, Leicester, LE1 9BH (United Kingdom); Ikemura, Noriaki; Inoue, Kiyoshi; Miyataka, Hideki; Himeno, Seiichiro [Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514 (Japan)] [Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514 (Japan); Hossain, Khaled, E-mail: khossain69@yahoo.com [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)

2012-03-01T23:59:59.000Z

423

CANDU human performance analysis  

SciTech Connect (OSTI)

An evaluation of human performance is presented in this paper in the context of the operational safety management system. To focus on problems, an experience review program has been developed to establish trends, demonstrate the degree of compliance with standards, and determine the causes of poor performance. The primary method by which the experience review takes place is significant event reporting (SER). A significant event is an incident that causes an undesirable effect on safety, product quality, environmental protection, or product cost. In spite of advanced technology and the degree of automation of the Canada deuterium uranium (CANDU) design, mistakes and malfunctions to occur. Considerable effort has been made to prevent or reduce the incidence of error. The Institute of Nuclear Power Operations developed a system to analyze human error, called the Human Performance Evaluation System (HPES). To encourage an open exchange of information, the system is anonymous and nonpunitive. All data gathered during HPES evaluations are kept confidential.

Walker, I.

1987-01-01T23:59:59.000Z

424

Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo  

SciTech Connect (OSTI)

Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100 ?M) altered human and rat heart slice markers of oxidative stress (ATP and GSH) at 24 h. In this in vivo rat study (0.5 mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48 h. In the rat and the human heart, isoproterenol altered pathways for apoptosis/necrosis, stress/energy, inflammation, and remodeling/fibrosis. The rat and human heart slices were in an apoptotic phase, while the in vivo rat heart exhibited necrosis histologically and further progression of tissue remodeling. In human heart slices genes for several heat shock 70 kD members were altered, indicative of stress to mitigate apoptosis. The stress response included alterations in energy utilization, fatty acid processing, and the up-regulation of inducible nitric oxide synthase, a marker of increased oxidative stress in both species. Inflammation markers linked with remodeling included IL-1?, Il-1?, IL-6 and TNF? in both species. Tissue remodeling changes in both species included increases in the TIMP proteins, inhibitors of matrix degradation, the gene/protein of IL-4 linked with cardiac fibrosis, and the gene Ccl7 a chemokine that induces collagen synthesis, and Reg3b a growth factor for cardiac repair. This study demonstrates that the initial human heart slice response to isoproterenol cardiac injury results in apoptosis, stress/energy status, inflammation and tissue remodeling at concentrations similar to that in rat heart slices. - Highlights: • Human response to isoproterenol induced cardiac injury evaluated in heart slices. • Isoproterenol altered apoptosis, energy, inflammation and remodeling pathways. • Human model verified by comparison to rat heart slices and rat heart in vivo. • Human and rat respond to isoproterenol at similar concentrations in vitro.

Herrmann, Julia E.; Heale, Jason; Bieraugel, Mike; Ramos, Meg [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States); Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States)

2014-01-15T23:59:59.000Z

425

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

426

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

427

Studies of Bystander Effects in 3-D Tissue Systems Using a Low-LET Microbeam  

SciTech Connect (OSTI)

It is now accepted that biological effects may occur in cells that were not themselves traversed by ionizing radiation but are close to those that were. Little is known about the mechanism underlying such a bystander effect, although cell-to-cell communication is thought to be important. Previous work demonstrated a significant bystander effect for clonogenic survival and oncogenic transformation in C3H 10T(1/2) cells. Additional studies were undertaken to assess the importance of the degree of cell-to-cell contact at the time of irradiation on the magnitude of this bystander effect by varying the cell density. When 10% of cells were exposed to a range of 2-12 alpha particles, a significantly greater number of cells were inactivated when cells were irradiated at high density than at low density. In addition, the oncogenic transformation frequency was significantly higher in high-density cultures. These results suggest that when a cell is hit by radiation, the transmission of the bystander signal through cell-to-cell contact is an important mediator of the effect, implicating the involvement of intracellular communication through gap junctions. Additional studies to address the relationship between the bystander effect and the adaptive response were undertaken. A novel apparatus, where targeted and non-targeted cells were grown in close proximity, was used to investigate these. It was further examined whether a bystander effect or an adaptive response could be induced by a factor(s) present in the supernatants of cells exposed to a high or low dose of X-rays, respectively. When non-hit cells were co-cultured for 24 h with cells irradiated with 5 Gy alpha-particles, a significant increase in both cell killing and oncogenic transformation frequency was observed. If these cells were treated with 2 cGy X-rays 5 h before co-culture with irradiated cells, approximately 95% of the bystander effect was cancelled out. A 2.5-fold decrease in the oncogenic transformation frequency was also observed. When cells were cultured in medium donated from cells exposed to 5 Gy X-rays, a significant bystander effect was observed for clonogenic survival. When cells were cultured for 5 h with supernatant from donor cells exposed to 2 cGy and were then irradiated with 4 Gy X-rays, they failed to show an increase in survival compared with cells directly irradiated with 4 Gy. However, a twofold reduction in the oncogenic transformation frequency was seen. An adaptive dose of X-rays cancelled out the majority of the bystander effect produced by alpha-particles. For oncogenic transformation, but not cell survival, radioadaption can occur in unirradiated cells via a transmissible factor(s). A pilot study was undertaken to observe the bystander effect in a realistic multicellular three-dimensional morphology. We found bystander responses in a three-dimensional, normal human-tissue system. Endpoints were induction of micronucleated and apoptotic cells. A charged-particle microbeam was used, allowing irradiation of cells in defined locations in the tissue yet guaranteeing that no cells located more than a few micrometers away receive any radiation exposure. Unirradiated cells up to 1 mm distant from irradiated cells showed a significant enhancement in effect over background, with an average increase in effect of 1.7-fold for micronuclei and 2.8-fold for apoptosis. The surprisingly long range of bystander signals in human tissue suggests that bystander responses may be important in extrapolating radiation risk estimates from epidemiologically accessible doses down to very low doses where nonhit bystander cells will predominate. Finally, it would be of great benefit to develop a reproducible tissue system suitable for critical radiobiological assays. We have developed a reliable protocol to harvest cells from tissue samples and to investigate the damage induced on a single cell basis. In order to result in a valid tool for bystander experiments, the method focuses on processing and analyzing radiation damage in individual cells as a function of their rela

Brenner, David J.

2009-07-17T23:59:59.000Z

428

Development of a combined model of tissue kinetics and radiation response of human bronchiolar epithelium with single cell resolution  

E-Print Network [OSTI]

Lack of accurate data for epidemiological studies of low dose radiation effects necessitates development of dosimetric models allowing prediction of cancer risks for different organs. The objective of this work is to develop a model of the radiation...

Ostrovskaya, Natela Grigoryevna

2006-10-30T23:59:59.000Z

429

Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance  

E-Print Network [OSTI]

Fine needle aspiration biopsy (FNAB) is a rapid and cost-effective method for obtaining a first-line diagnosis of a palpable mass of the breast. However, because it can be difficult to manually discriminate between adipose ...

Iftimia, Nicusor V.

430

Magnetic reconnection on the ion-skin-depth scale in the dusty magnetotail of a comet  

SciTech Connect (OSTI)

Resistive magnetic reconnection is studied in a dusty plasma configuration without a guide magnetic field, typical for cometary tails. For a high-{beta} plasma ({beta}{approx}1) consisting of electrons, ions, and immobile dust grains that constitute a neutralizing background, a two-fluid description is used to study electromagnetic perturbations with the frequency below the ion gyrofrequency, propagating at an arbitrary angle relative to the background magnetic field and including the effects of the Hall current. The perturbations consist of both the compressional and torsional components of the magnetic field, as well as of the acoustic perturbations and the electrostatic potential. The symmetry breaking between electrons and ions, introduced by the presence of dust grains, gives rise to an E-vectorxB-vector current in the unperturbed state which can support an antiparallel magnetic field configuration even in a cold plasma. In the perturbed state, the emergence of a new electromagnetic mode in a dusty plasma, which is evanescent below the Rao cutoff frequency and has the characteristic wavelength comparable to the ion skin depth, enables the reconnection at short spatial scales. The growth rate of the tearing instability is evaluated analytically.

Jovanovic, D.; Shukla, P.K.; Morfill, G. [Institute of Physics, P.O. Box 57, 11001 Belgrade (Serbia and Montenegro); Institut fuer Theoretische Physik IV, Ruhr-Universitaet Bochum, D-44780 Bochum (Germany); Max-Planck-Institut fuer extraterrestrische Physik, D-85740 Garching (Germany)

2005-04-15T23:59:59.000Z

431

Optical properties of metals: Infrared emissivity in the anomalous skin effect spectral region  

SciTech Connect (OSTI)

When the penetration depth of an electromagnetic wave in a metal is similar to the mean free path of the conduction electrons, the Drude classical theory is no longer satisfied and the skin effect becomes anomalous. Physical parameters of this theory for twelve metals were calculated and analyzed. The theory predicts an emissivity peak ?{sub peak} at room temperature in the mid-infrared for smooth surface metals that moves towards larger wavelengths as temperature decreases. Furthermore, the theory states that ?{sub peak} increases with the emission angle but its position, ?{sub peak}, is constant. Copper directional emissivity measurements as well as emissivity obtained using optical constants data confirm the predictions of the theory. Considering the relationship between the specularity parameter p and the sample roughness, it is concluded that p is not the simple parameter it is usually assumed to be. Quantitative comparison between experimental data and theoretical predictions shows that the specularity parameter can be equal to one for roughness values larger than those predicted. An exhaustive analysis of the experimental optical parameters shows signs of a reflectance broad peak in Cu, Al, Au, and Mo around the wavelength predicted by the theory for p?=?1.

Echániz, T. [Departamento de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, UPV/EHU, Sarriena s/n, Leioa 48940 (Spain); Pérez-Sáez, R. B., E-mail: raul.perez@ehu.es; Tello, M. J. [Departamento de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, UPV/EHU, Sarriena s/n, Leioa 48940 (Spain); Instituto de Síntesis y Estudio de Materiales, Universidad del País Vasco, Apdo. 644, Bilbao 48080 (Spain)

2014-09-07T23:59:59.000Z

432

Coordination-resolved local bond contraction and electron binding-energy entrapment of Si atomic clusters and solid skins  

SciTech Connect (OSTI)

Consistency between x-ray photoelectron spectroscopy measurements and density-function theory calculations confirms our bond order-length-strength notation-incorporated tight-binding theory predictions on the quantum entrapment of Si solid skin and atomic clusters. It has been revealed that bond-order deficiency shortens and strengthens the Si-Si bond, which results in the local densification and quantum entrapment of the core and valence electrons. Unifying Si clusters and Si(001) and (111) skins, this mechanism has led to quantification of the 2p binding energy of 96.089?eV for an isolated Si atom, and their bulk shifts of 2.461?eV. Findings evidence the significance of atomic undercoordination that is of great importance to device performance.

Bo, Maolin; Huang, Yongli; Zhang, Ting [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); Wang, Yan, E-mail: ywang8@hnust.edu.cn, E-mail: ecqsun@ntu.edu.sg [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); School of Information and Electronic Engineering, Hunan University of Science and Technology, Hunan 411201 (China); Zhang, Xi [School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 (Singapore); Li, Can [Center for Coordination Bond Engineering, School of Materials Science and Engineering, China Jiliang University, Hangzhou 330018 (China); Sun, Chang Q., E-mail: ywang8@hnust.edu.cn, E-mail: ecqsun@ntu.edu.sg [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 (Singapore); Center for Coordination Bond Engineering, School of Materials Science and Engineering, China Jiliang University, Hangzhou 330018 (China)

2014-04-14T23:59:59.000Z

433

Human Processing (Position Paper)  

E-Print Network [OSTI]

and describe remaining challenges in the area (Section 6). 2. MOTIVATING EXAMPLE "Priam," the editor below, we explain how Priam might go about accomplishing this task. Figure 1: Basic Buyer human. The programmer (Priam) writes a normal program. 2. That program can, in the course of execution, create HTML

Chang, Edward Y.

434

transforming human health  

E-Print Network [OSTI]

transforming human health AnnUAl REpoRt 2011­2012 #12;#12;how we're changing medical research 1 are transforming health. He proposed an entirely new theory for developing drugs to treat diseases that have malaria and solid tumors such as lung and breast cancers are in development. #12;A TrAnsformATive educ

Kenny, Paraic

435

Elimination of influence of neutron-skin size difference of initial colliding nuclei in Pb+Pb collisions  

E-Print Network [OSTI]

Within an isospin- and momentum-dependent transport model using as an input nucleon density profiles from Hartree-Fock calculations based on a modified Skyrme-like (MSL) model, we study how to eliminate the influence of neutron-skin size difference of initial colliding nuclei in probing the nuclear symmetry energy. Within the current experimental uncertainty range of neutron-skin size of $^{208}$Pb, the Pb+Pb collisions are performed in semicentral and peripheral collisions with impact parameters of 5 and 9fm and at beam energies from 50 MeV/nucleon to 1000 MeV/nucleon, respectively. It is shown that combination of neutron and proton collective flows, i.e., neutron-proton differential elliptic flow, neutron-proton elliptic flow difference, neutron-proton differential transverse flow and neutron-proton transverse flow difference, can effectively eliminate the effects of neutron-skin size difference and thus can be as useful sensitive observables in probing nuclear matter symmetry energy in heavy-ion collisions...

Wei, Gao-Feng

2015-01-01T23:59:59.000Z

436

Locoregional Outcomes of Inflammatory Breast Cancer Patients Treated With Standard Fractionation Radiation and Daily Skin Bolus in the Taxane Era  

SciTech Connect (OSTI)

Purpose: To assess locoregional outcomes of inflammatory breast cancer (IBC) patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy (CMT). Methods and Materials: We retrospectively reviewed the charts of 107 patients diagnosed with IBC between January 1995 and March 2006 who presented to our department for adjuvant radiation therapy (RT). Results: All patients received chemotherapy (95% anthracycline and 95% taxane), modified radical mastectomy, and RT to the chest wall and regional lymphatics using standard fractionation to 50 Gy and daily skin bolus. The RT to the chest wall was delivered via electrons (55%) or photons (45%) in daily fractions of 180 cGy (73%) or 200 cGy (27%). Scar boost was performed in 11%. A majority (84%) of patients completed the prescribed treatment. Median follow-up was 47 months (range, 10-134 months). Locoregional control (LRC) at 3 years and 5 years was 90% and 87%, respectively. Distant metastases-free survival (DMFS) at 3 years and 5 years was 61% and 47%, respectively. Conclusions: Excellent locoregional control was observed in this population of IBC patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy. Distant metastases-free survival remains a significant therapeutic challenge.

Damast, Shari, E-mail: damasts@mskcc.or [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Ho, Alice Y. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Montgomery, Leslie [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Fornier, Monica N. [Department of Breast Cancer Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Ishill, Nicole; Elkin, Elena [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Beal, Kathryn; McCormick, Beryl [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2010-07-15T23:59:59.000Z

437

Human sciences The human sciences database contains approximately 254 academic  

E-Print Network [OSTI]

Human sciences The human sciences database contains approximately 254 academic journals and statistical reports on the following subjects: (comparative literature, theology, history and geography, education, psychology, arts, languages and Library Science) Social sciences The social sciences database

438

Human-elephant conflicts; Human-elephant conflicts.  

E-Print Network [OSTI]

?? It is widely recognized that human-wildlife conflicts can reduce farmers’ support for long-term species conservation. The subject of human-elephant conflicts is highly relevant in… (more)

Olsson, Linnea

2014-01-01T23:59:59.000Z

439

CATHETER SURFACE INTERACTIONS WITH HUMAN  

E-Print Network [OSTI]

and Porosity positively impacts lubricity and reduces tissue trauma. Con: Hydrogel tends to delaminate due of Polyurethane Catheter (uncoated) Polyurethane coated with Poly (MCP-co- BMA) polymer Test enviroments: Vacuum

MĂĽftĂĽ, Sinan

440

Policy on Human Subjects Research Policy on Human Subjects  

E-Print Network [OSTI]

Policy on Human Subjects Research 10/15/2014 Policy on Human Subjects Research I. Purpose and Scope requirements that the rights and welfare of human subjects receive adequate protection. This policy applies, except that research conducted or assigned as part of their coursework is governed by the Policy

Sridhar, Srinivas

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Mechanisms underlying cellular responses of cells from haemopoietic tissue to low  

SciTech Connect (OSTI)

The above studies will provide fundamental mechanistic information relating genetic predisposition to important low dose phenomena, and will aid in the development of Department of Energy policy, as well as radiation risk policy for the public and the workplace. We believe the proposed studies accurately reflect the goals of the DOE low dose program. To accurately define the risks associated with human exposure to relevant environmental doses of low LET ionizing radiation, it is necessary to completely understand the biological effects at very low doses (i.e. less than 0.1 Gy), including the lowest possible dose, that of a single electron track traversal. At such low doses, a range of studies have shown responses in biological systems which are not related to the direct interaction of radiation tracks with DNA. The role of these "Ă?Â?non-targeted"Ă?Âť responses in critical tissues is poorly understood and little is known regarding the underlying mechanisms. Although critical for dosimetry and risk assessment, the role of individual genetic susceptibility in radiation risk is not satisfactorily defined at present. The aim of the proposed grant is to critically evaluate non-targeted effects of ionizing radiation with a focus on the induction of genomic instability (GI) in key stem cell populations from haemopoietic tissue. Using stem cells from two mouse strains (CBA/CaH and C57BL/6J) known to differ in their susceptibility to radiation effects, we plan to carefully dissect the role of genetic predisposition in these models on genomic instability. We will specifically focus on the effects of low doses of low LET radiation, down to the dose of 10mGy (0.01Gy) X-rays. Using conventional X-ray and we will be able to assess the role of genetic variation under various conditions at a range of doses down to the very low dose of 0.01Gy. Irradiations will be carried out using facilities in routine operation for such studies. Mechanistic studies of instability in different cell lineages will include the role of cytokines which have been shown to be in the initiation of instability. These studies also aim to uncover the possible mechanism of the initiation, perpetuation and delayed pathways of the instability response using relevant biological endpoints i.e. chromosomal instability, apoptosis induction, cytokine and gene array analysis. Integral to these studies will be an assessment of the role of genetic susceptibility in these responses, using CBA/CaH and C57BL/6J mice. The overall results suggest that low dose low LET X-irradiation induced delayed GI in both CBA/CaH and C57BL/6J haemopoeitic tissue. Using several biological approaches, some key strain and dose-specific differences have been identified in radiation-induced signalling in the initiation and perpetuation of the instability process. Furthermore, the induction of non-targeted radiation effects and genetic dependency may be linked to the use of alternative signalling pathways and mechanisms which have potential implications on evaluation of non-targeted effects in radiation risk assessment.

Kadhim, Munira A

2012-08-22T23:59:59.000Z

442

E-Print Network 3.0 - autometallography tissue metals Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

previously for localization of trace metals ions in tissues. By exploiting... to heavy metal toxicology. Pharmacol Toxicol 68:414-423 Danscher G (1984) Autometallography. A new......

443

E-Print Network 3.0 - absorption tissue distribution Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

tomography with the frequency domain equation of radiative transfer Summary: of radiative transfer. Transport properties of tissue become significant when strong light...

444

Postoperative soft tissue defects in the ankle area : The etiology and methods of reconstruction.  

E-Print Network [OSTI]

??The risk is obvious for soft tissue complications after operative treatment of the Achilles tendon, calcaneal bone or after ankle arthroplasty. Such complications after malleolar… (more)

Koski, Antti

2010-01-01T23:59:59.000Z

445

E-Print Network 3.0 - adult medullary tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

EXPLAINS DIFFERENCES IN HYDRODYNAMIC PERFORMANCES OF FOLIOSE RED Summary: that increased blade thickness (primarily caused by the addition of medullary tissue) results in higher...

446

E-Print Network 3.0 - amniotic membrane tissue Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1978 1131 Summary: -abortion examination of fetal tissues. Results Cell-free amniotic fluids were passed through the affinity column... CLIN.CHEM.247, 1131-1133(1978)...

447

E-Print Network 3.0 - animal tissue samples Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: infectious agents and contaminated samples between the laboratory and animal facility in a sealed, secondary... tissue harvest in the animal room or arrange with animal...

448

E-Print Network 3.0 - ameliorate inflammation-related tissue...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

as well as a molecular medical imaging tool. Owing... to the scattering nature of near infrared radiation in tissue, iterative tomography approaches must employ... the coupled...

449

E-Print Network 3.0 - adipose tissue-derived mesenchymal Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of adipose tissue distribution in mice in vivo. Moreover, we have developed an automatic image analysis Source: Ecole Polytechnique, Centre de mathmatiques Collection:...

450

E-Print Network 3.0 - adipose tissue play Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

obesity... be estimated by determining the tissue (i.e., skeletal muscle, ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

451

E-Print Network 3.0 - adipose tissue leptin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the strength Summary: loss of other functions provided by adipose tissue besides leptin secretion -- for example, functions... in correcting diabetes. A-ZIPF-1 mice (Table 1)...

452

adipose tissue stromal-vascular: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

study investigates the potential anti-inflammatory effects of in vivo oxytocin (OT) infusion on adipose tissue inflammation in the Watanabe Heritable Hyperlipidimic Rabbits...

453

E-Print Network 3.0 - annulus fibrosus tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: annulus fibrosus tissue Page: << < 1 2 3 4 5 > >> 1 Mechanical and Aerospace Engineering Colloquium Series Summary: : the nucleus pulposus and the...

454

E-Print Network 3.0 - advanced soft tissue Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Sample search results for: advanced soft tissue Page: << < 1 2 3 4 5 > >> 1 MECHANICAL AND AEROSPACE ENGINEERING COLLOQUIUM SERIES Summary: -sponsored by the CU-ADVANCE...

455

E-Print Network 3.0 - ahr system tissue-specific Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pattern of tissue-specific... the aryl hydrocarbon receptor (AHR), through which dioxins and dioxin-like compounds cause altered gene... -methylcholanthrene AHH: aryl...

456

Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers  

E-Print Network [OSTI]

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery ...

Wang, Jane

457

E-Print Network 3.0 - assemblies target tissues Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of a Fibrin-Based Tissue Construct ... Source: George, Steven C. - Department of Biomedical Engineering, University of California, Irvine Collection: Biology and Medicine 2...

458

Effects of PGF{sub 2{alpha}} on human melanocytes and regulation of the FP receptor by ultraviolet radiation  

SciTech Connect (OSTI)

Prostaglandins are potent lipid hormones that activate multiple signaling pathways resulting in regulation of cellular growth, differentiation, and apoptosis. In the skin, prostaglandins are rapidly released by keratinocytes following ultraviolet radiation and are chronically present in inflammatory skin lesions. We have shown previously that melanocytes, which provide photoprotection to keratinocytes through the production of melanin, express several receptors for prostaglandins, including the PGE{sub 2} receptors EP{sub 1} and EP{sub 3} and the PGF{sub 2{alpha}} receptor FP, and that PGF{sub 2{alpha}} stimulates melanocyte dendricity. We now show that PGF{sub 2{alpha}} stimulates the activity and expression of tyrosinase, the rate-limiting enzyme in melanin synthesis. Analysis of FP receptor regulation showed that the FP receptor is regulated by ultraviolet radiation in melanocytes in vitro and in human skin in vivo. We also show that ultraviolet irradiation stimulates production of PGF{sub 2{alpha}} by melanocytes. These results show that PGF{sub 2{alpha}} binding to the FP receptor activates signals that stimulate a differentiated phenotype (dendricity and pigmentation) in melanocytes. The regulation of the FP receptor and the stimulation of production of PGF{sub 2{alpha}} in melanocytes in response to ultraviolet radiation suggest that PGF{sub 2{alpha}} could act as an autocrine factor for melanocyte differentiation.

Scott, Glynis [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)]. E-mail: Glynis_Scott@urmc.rochester.edu; Jacobs, Stacey [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Leopardi, Sonya [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Anthony, Frank A. [Schering-Plough HealthCare Products Inc., Memphis TN (United States); Learn, Doug [Charles River DDS, Argus Division, Horsham, PA (United States); Malaviya, Rama [University of Medicine and Dentistry, RWJMS, New Brunswick, NJ (United States); Pentland, Alice [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)

2005-04-01T23:59:59.000Z

459

The effect of Stromal cell Derived Factor-1 (SDF-1) and collagen-GAG (Glycosaminoglycan) scaffold on skin wound healing  

E-Print Network [OSTI]

Wound healing is an intricate biological process requiring the appropriate balance of matrix and growth factors. Apart from causing physical deformity, adult wound healing results in the formation of scar tissue, which can ...

Sarkar, Aparajita

2008-01-01T23:59:59.000Z

460

Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994  

SciTech Connect (OSTI)

Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

NONE

1995-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Human Capital Management Accountability Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

2008-08-01T23:59:59.000Z

462

Human factors evaluation of teletherapy: Literature review. Volume 5  

SciTech Connect (OSTI)

A series of human factors evaluations were undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multidisciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation therapists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was performed initially to guide subsequent evaluations in the areas of workplace environment, system-user interfaces, procedures, training, and organizational practices. To further acquire an in-depth and up-to-date understanding of the practice of teletherapy in support of these evaluations, a systematic literature review was conducted. Factors that have a potential impact on the accuracy of treatment delivery were of primary concern. The present volume is the literature review. The volume starts with an overview of the multiphased nature of teletherapy, and then examines the requirement for precision, the increasing role of quality assurance, current conceptualizations of human error, and the role of system factors such as the workplace environment, user-system interfaces, procedures, training, and organizational practices.

Henriksen, K.; Kaye, R.D.; Jones, R. [Hughes Training, Inc., Falls Church, VA (United States); Morisseau, D.S.; Serig, D.L. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology

1995-07-01T23:59:59.000Z

463

Tissue Heterogeneity in IMRT Dose Calculation for Lung Cancer  

SciTech Connect (OSTI)

The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulated radiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the {gamma} function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the lung and in the tumor area. These differences are not always in DVH of the lung, although the Wilcoxon test indicated significant differences in 2 of 4 patients. Disagreement in the lung region was also found when the {Gamma} analysis was performed. The effect on TCP is less important than for NTCP because of the slope of the curve at the level of the dose of interest. The effect of dose calculation inaccuracy is patient-dependent and strongly related to beam geometry and to the localization of the tumor. When multiple intensity-modulated beams are used, the effect of the presence of the heterogeneity on dose distribution may not always be easily predictable.

Pasciuti, Katia, E-mail: ka.pasciuti@libero.i [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Iaccarino, Giuseppe; Strigari, Lidia [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Malatesta, Tiziana [Medical Physics Department, S. Giovanni Calibita, Fatebenefratelli Hospital, Roma (Italy); Benassi, Marcello; Di Nallo, Anna Maria [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy); Mirri, Alessandra; Pinzi, Valentina [Division of Radiotherapy, Istituto Regina Elena, Roma (Italy); Landoni, Valeria [Laboratory of Medical Physics, Istituto Regina Elena, Roma (Italy)

2011-07-01T23:59:59.000Z

464

Tissue phantom ratios for a Clinac 4/100  

SciTech Connect (OSTI)

Tissue phantom ratios (TPR), based on a normalization depth of 5 cm, have been measured in water for field sizes from 5 x 5 cm/sup 2/ to approximately 40 x 40 cm/sup 2/ and for depths from 1 to 40 cm for a Varian Clinac 4/100. These TPR's have been compared with those calculated from percent depth doses measured at the same time, and the two sets of data generally agree to better than 1%, with an average ratio of measured to calculated TPR of 0.999 +- 0.013. Beam profiles have been measured for open and wedged fields, with particular concern for the often observed ''horns,'' or the increase in dose at the corners of the field. The maximum dose at a depth of 1 cm, along the diagonal of the field for this machine, is approximately 5% higher than at the same depth on the central axis, whereas along the principal plane the maximum dose is only about 3% higher.

Biggs, P.J.; Doppke, K.P.; Leong, J.C.; Russell, M.D.

1982-09-01T23:59:59.000Z

465

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice  

E-Print Network [OSTI]

Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B ...

Chen, Qingfeng

466

Differential expression of RANK on Langerhans cells and CD45RA and CD45RO/CLA on T cells in developing human skin after birth.  

E-Print Network [OSTI]

??Die Haut, die Schnittstelle zwischen dem Körper und der Umgebung, ist das größte Organ des Körpers und hat zahlreiche Funktionen. Eine davon ist, dass die… (more)

Akguen, Johnnie

2010-01-01T23:59:59.000Z

467

Biological therapy of strontium-substituted bioglass for soft tissue wound-healing  

E-Print Network [OSTI]

Biological therapy of strontium-substituted bioglass for soft tissue wound-healing: Responses to oxidative stress in ovariectomised rats La thérapie biologique de verre bioactif substitué au strontium pour and regeneration. Bioactive glasses (BG) containing strontium have shown successful applicationsin tissue

Paris-Sud XI, Université de

468

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Array Coil  

E-Print Network [OSTI]

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Carolina at Chapel Hill Abstract The acquisition of high quality MR images of neonatal brains is largely hampered by their characteristically small head size and low tissue contrast. As a result, subsequent image

Utah, University of

469

ACQUISITION AND RECONSTRUCTION OF BRAIN TISSUE USING KNIFE-EDGE SCANNING MICROSCOPY  

E-Print Network [OSTI]

ACQUISITION AND RECONSTRUCTION OF BRAIN TISSUE USING KNIFE- EDGE SCANNING MICROSCOPY A Thesis Science #12;ACQUISITION AND RECONSTRUCTION OF BRAIN TISSUE USING KNIFE- EDGE SCANNING MICROSCOPY A Thesis) ______________________________ ______________________________ Ergun Akleman Valerie Taylor (Member) (Head of Department) December 2003 Major Subject: Computer Science

Keyser, John

470

RADIATION HEAT TRANSFER IN TISSUE WELDING AND SOLDERING WITH ULTRAFAST LASERS  

E-Print Network [OSTI]

RADIATION HEAT TRANSFER IN TISSUE WELDING AND SOLDERING WITH ULTRAFAST LASERS Kyunghan Kim to incorporate transient radiation heat transfer in tissue welding and soldering with use of ultrafast lasers are performed between laser welding and laser soldering. The use of solder is found to substantially enhance

Guo, Zhixiong "James"

471

Engineered Heart Tissue Model of Diabetic Myocardium Hannah Song, Ph.D.,1  

E-Print Network [OSTI]

Engineered Heart Tissue Model of Diabetic Myocardium Hannah Song, Ph.D.,1 Peter W. Zandstra, Ph of cardiomyocytes (CMs) is a leading cause of heart failure. Previously, we reported an in vitro test-bed for screening cell integration between injected test cells and host CM using the engineered heart tissue

Zandstra, Peter W.

472

Engineered Heart Tissue Enables Study of Residual Undifferentiated Embryonic Stem Cell Activity in a  

E-Print Network [OSTI]

ARTICLE Engineered Heart Tissue Enables Study of Residual Undifferentiated Embryonic Stem Cell, Canada, M5S 3G9 6 Heart and Stroke/Richard Lewar Centre of Excellence, Toronto, Ontario, Canada, M5S 3G9 cell survival. As an alternative, we have used an engineered heart tissue (EHT) based on neonatal rat

Zandstra, Peter W.

473

Prevention of tissue damage by water jet during cavitation Daniel Palanker,a)  

E-Print Network [OSTI]

Prevention of tissue damage by water jet during cavitation Daniel Palanker,a) Alexander Vankov Cavitation bubbles accompany explosive vaporization of water following pulsed energy deposition in liquid can produce tissue damage at a distance exceeding the radius of the cavitation bubble by a factor of 4

Palanker, Daniel

474

Optimizing the Utility System of a Tissue Paper Mill Using Pinch Technology  

E-Print Network [OSTI]

A tissue paper mill in southern California had existing utility demands of 7.1 MW for the tissue mill (13 MW for the whole site), and 55 MM Btu/hr of fuel gas for the steam boiler. Total utility costs were $12 MM per year. The mill was seriously...

Kumana, J. D.; Sung, R. D.

475

The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue  

E-Print Network [OSTI]

The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue propagation without breakup, plane wave breakup into spiral waves and plane wave block. In the theoretical with the propagation of an electrical wave through the cardiac tissue in a coordinated manner. The wave of activity

Glass, Leon

476

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of  

E-Print Network [OSTI]

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B (received for review September 1, 2004) Chronic ethanol abuse causes up-regulation of NMDA receptors, which underlies seizures and brain damage upon ethanol with- drawal (EW). Here we show that tissue

477

Human Resources Organizational Development and Training 1  

E-Print Network [OSTI]

Human Resources Organizational Development and Training 1 Development Guide for Tufts Leadership Competencies Human Resources Training, Learning and Development Copyright © 2013 Tufts University Developed with Copperbeech Group Inc. #12;Human Resources Training, Learning and Development 2 #12;Human Resources Training

Dennett, Daniel

478

Selenium induced lipid peroxidation in heart tissues of chick embryos  

SciTech Connect (OSTI)

During the past three decades research has been carried out to elucidate the role of free radicals and reactive oxygen species play in various pathophysiological processes. Membranes of subcellular organelles contain relatively high concentrations of polyunsaturated lipids as well as hemoproteins which are strong catalysts of lipid peroxidation. Lipid peroxides (LPO) destroy membrane integrity and decrease membrane fluidity and elasticity. Selenium is known both as an important essential trace element and an environmental pollutant. Selenium has many uses in the industries. The main source of selenium for the mammalian organism is food (from the soil into the vegetables and grain) and to a lesser extent, drinking water. A number of syndromes of selenium toxicity in animals have been described. Selenium is regarded as the most important biological antioxidant. The antioxidant function of selenium is linked to the activity of seleno enzyme glutathione peroxidase (GPx), which catalyses the reduction of hydroperoxides. The antioxidant enzymes like superoxide dismutase (SOD) reduce superoxide radicals to H[sub 2]O[sub 2] which inturn is preferential oxidation of glutathione by peroxides is catalysed by GPx. The oxidized glutathione is then reduced by glutathione reductase (GR) and maintains the reduced glutathione levels in the system in a cyclic manner. Further, glutathione transferase (GST) catalyses the transformation of a wide variety of electrophilic compounds to less toxic compounds by conjugating them to GSH. The present study evaluated the biochemical basis of selenium induced lipid peroxidative damage to heart tissues in check embryos and the role of antioxidant enzymes like GPx, GST, GR, SOD and CAT. 24 refs., 2 figs., 2 tabs.

Padmaja, K.; Somasekharaiah, B.V.; Prasad, A.R.K. (S.V. Univ., Tirupati (India))

1993-09-01T23:59:59.000Z

479

Mentoring Human Performance - 12480  

SciTech Connect (OSTI)

Although the positive effects of implementing a human performance approach to operations can be hard to quantify, many organizations and industry areas are finding tangible benefits to such a program. Recently, a unique mentoring program was established and implemented focusing on improving the performance of managers, supervisors, and work crews, using the principles of Human Performance Improvement (HPI). The goal of this mentoring was to affect behaviors and habits that reliably implement the principles of HPI to ensure continuous improvement in implementation of an Integrated Safety Management System (ISMS) within a Conduct of Operations framework. Mentors engaged with personnel in a one-on-one, or one-on-many dialogue, which focused on what behaviors were observed, what factors underlie the behaviors, and what changes in behavior could prevent errors or events, and improve performance. A senior management sponsor was essential to gain broad management support. A clear charter and management plan describing the goals, objectives, methodology, and expected outcomes was established. Mentors were carefully selected with senior management endorsement. Mentors were assigned to projects and work teams based on the following three criteria: 1) knowledge of the work scope; 2) experience in similar project areas; and 3) perceived level of trust they would have with project management, supervision, and work teams. This program was restructured significantly when the American Reinvestment and Recovery Act (ARRA) and the associated funding came to an end. The program was restructured based on an understanding of the observations, attributed successes and identified shortfalls, and the consolidation of those lessons. Mentoring the application of proven methods for improving human performance was shown effective at increasing success in day-to-day activities and increasing confidence and level of skill of supervisors. While mentoring program effectiveness is difficult to measure, and return on investment is difficult to quantify, especially in complex and large organizations where the ability to directly correlate causal factors can be challenging, the evidence presented by Sydney Dekker, James Reason, and others who study the field of human factors does assert managing and reducing error is possible. Employment of key behaviors-HPI techniques and skills-can be shown to have a significant impact on error rates. Our mentoring program demonstrated reduced error rates and corresponding improvements in safety and production. Improved behaviors are the result, of providing a culture with consistent, clear expectations from leadership, and processes and methods applied consistently to error prevention. Mentoring, as envisioned and executed in this program, was effective in helping shift organizational culture and effectively improving safety and production. (authors)

Geis, John A.; Haugen, Christian N. [CALIBRE Systems, Inc., Alexandria, Virginia (United States)

2012-07-01T23:59:59.000Z

480

Human Genome Program  

SciTech Connect (OSTI)

The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

Not Available

1993-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin tissue" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Human Resources | Jefferson Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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482

Human Genome: DOE Origins  

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483

Jefferson Lab Human Resources  

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484

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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485

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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486

Jefferson Lab Human Resources  

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487

Jefferson Lab Human Resources  

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488

Jefferson Lab Human Resources  

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489

Jefferson Lab Human Resources  

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490

Jefferson Lab Human Resources  

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491

Jefferson Lab Human Resources  

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492

PIA - Human Resources - Personal Information Change Request ...  

Office of Environmental Management (EM)

PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National...

493

Effects of the co-carcinogen catechol on benzo(a)pyrene metabolism and DNA adduct formation in mouse skin  

SciTech Connect (OSTI)

We have studied the effects of the co-carcinogen catechol (1,2-dihydroxybenzene) on the metabolic activation of (/sup 3/H) benzo(a)pyrene (BaP) in mouse skin, in vivo and on the binding of BaP metabolites to DNA and protein at intervals from 0.5-24 h. Upon topical application of 0.015 mg (/sup 3/H)BaP and 0.25 or 0.5 mg catechol per mouse, catechol had little effect on the total amount of (/sup 3/H)BaP metabolized in mouse skin, but it affected the relative proportions of (/sup 3/H)BaP metabolites. Catechol (0.5 mg/mouse) decreased the proportion of water-soluble (/sup 3/H)BaP metabolites, ethyl acetate-soluble polar metabolites and quinones, but doubled the levels of unconjugated 3-hydroxy-BaP at all measured intervals after treatment. Catechol also caused a small increase in the levels of trans-7,8-dihydroxy-7,8-dihydroBaP and trans-9,10-dihydroxy-9,10-dihydroBaP 0.5 h after treatment. Two hours after treatment, the levels of these metabolites subsided to those of the controls. Catechol did not affect the levels of glutathione conjugates of BaP. However, it caused a decrease in glucuronide and sulphate conjugate formation from BaP. Catechol caused an approximately 2-fold increase in the formation of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydroBaP (BPDE) DNA adducts and elevated the ratio of anti-syn-BPDE-DNA adducts 1.6 to 2.9-fold. Catechol treatment increased the radioactivity associated with epidermal proteins after (/sup 3/H)BaP application. Because catechol increased levels of 3-hydroxyBaP, we considered the possibility that 3-hydroxyBaP might enhance the tumor initiating activities of BaP or BPDE in mouse skin; a bioassay demonstrated that this was not the case. The results of this study indicate that one important effect of catechol related to its co-carcinogenicity is its ability to enhance formation of anti-BPDE-DNA adducts in mouse skin.

Melikian, A.A.; Leszczynska, J.M.; Hecht, S.S.; Hoffmann, D.

1986-01-01T23:59:59.000Z

494

Human subjects research handbook: Protecting human research subjects. Second edition  

SciTech Connect (OSTI)

This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

NONE

1996-01-30T23:59:59.000Z

495

Human-computer interface  

DOE Patents [OSTI]

The present invention provides a method of human-computer interfacing. Force feedback allows intuitive navigation and control near a boundary between regions in a computer-represented space. For example, the method allows a user to interact with a virtual craft, then push through the windshield of the craft to interact with the virtual world surrounding the craft. As another example, the method allows a user to feel transitions between different control domains of a computer representation of a space. The method can provide for force feedback that increases as a user's locus of interaction moves near a boundary, then perceptibly changes (e.g., abruptly drops or changes direction) when the boundary is traversed.

Anderson, Thomas G.

2004-12-21T23:59:59.000Z

496

Human Reliability Program Workshop  

SciTech Connect (OSTI)

A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

Landers, John; Rogers, Erin; Gerke, Gretchen

2014-05-18T23:59:59.000Z

497

Simulating human behavior for national security human interactions.  

SciTech Connect (OSTI)

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

498

237Poverty and Human Capability Studies Poverty and Human  

E-Print Network [OSTI]

237Poverty and Human Capability Studies Poverty and Human CaPability StudieS (Pov) Core FaCulty: PROFESSORS beCKley*, GOLDSMITH, MARGAND The Shepherd Program for the interdisciplinary Study of Poverty and graduate studies can prepare them as futureprofessionalsandcitizenstoaddresstheproblems of poverty and how

Dresden, Gregory

499

227Poverty and Human Capability Studies Poverty AND HUMAN  

E-Print Network [OSTI]

227Poverty and Human Capability Studies Poverty AND HUMAN CAPABILIty StUDIeS (Pov) Core FACULty: PROFESSORS BeCKLey*, GOLDSMITH, MARGAND The Shepherd Program for the Interdisciplinary Study of Poverty studies can prepare them as future professionals and citizens to address the problems of poverty

Dresden, Gregory

500

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 51, NO. 12, DECEMBER 2004 2129 Influence of Head Tissue Conductivity in Forward  

E-Print Network [OSTI]

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 51, NO. 12, DECEMBER 2004 2129 Influence of Head Tissue Conductivity in Forward and Inverse Magnetoencephalographic Simulations Using Realistic Head Abstract--The influence of head tissue conductivity on mag- netoencephalography (MEG) was investigated

Utah, University of