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1

A Probabilistic Model for the Human Skin Color T.S. Caetano and D.A.C. Barone  

E-Print Network [OSTI]

,barone}@inf.ufrgs.br _____________________________________________ Abstract We present a multivariate statistical model to represent the human skin color. In our approach part in a fully automated facial analysis system, the first important step in recognizing faces to detect faces [1-6]. However, it is a well-known fact that the majority of images acquired today

Caetano, Tiberio

2

Thermal Modeling and Experimental Validation of Human Hair and Skin Heated by Broadband Light  

E-Print Network [OSTI]

distribution within the hair follicle is highly non-uniform: the minimum temperature occurs at the follicle Sun, PhD,1 Alex Chaney,1 Robert Anderson, PhD,2 and Guillermo Aguilar, PhD 1 * 1 Department:(a)determinetheoveralleffectofPPxonskinhumidi- tyandassociatedskinopticalproperties,and;(b)developaPT numerical model to study the spatial and temporal hair and skin temperature

Aguilar, Guillermo

3

Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5  

SciTech Connect (OSTI)

Reducing Cx43 expression stimulates skin wound healing. This is mimicked in models when Cx43 function is blocked by the connexin mimetic peptide Gap27. IGF-I also stimulates wound healing with IGFBP-5 attenuating its actions. Further, the IGF-I to IGFBP-5 ratio is altered in diabetic skin, where wound closure is impaired. We investigated whether Gap27 remains effective in augmenting scrape-wound closure in human skin wound models simulating diabetes-induced changes, using culture conditions with raised glucose, insulin and IGFBP-5. Gap27 increased scrape-wound closure in normal glucose and insulin (NGI) and to a lesser extent in high glucose and insulin (HGI). IGF-I enhanced scrape-wound closure in keratinocytes whereas IGFBP-5 inhibited this response. Gap27 overcame the inhibitory effects of IGFBP-5 on IGF-I activity. Connexin-mediated communication (CMC) was reduced in HGI, despite raised Cx43, and Gap27 significantly decreased CMC in NGI and HGI. IGF-I and IGFBP-5 did not affect CMC. IGF-I increased keratinocyte proliferation in NGI, and Gap27 increased proliferation in NGI to a greater extent than in HGI. We conclude that IGF-I and Gap27 stimulate scrape-wound closure by independent mechanisms with Gap27 inhibiting Cx43 function. Gap27 can enhance wound closure in diabetic conditions, irrespective of the IGF-I:IGFBP-5 balance. - Highlights: ? Human organotypic and keratinocyte ‘diabetic’ skin models were used to demonstrate the ability of Gap27 to improve scrape-wound closure. ? Gap27 enhanced scrape-wound closure by reducing Cx43-mediated communication, whereas IGFBP-5 retarded cell migration. ? IGF-I and IGFBP-5 did not affect connexin-mediated pathways. ? Gap27 can override altered glucose, insulin, IGF-I, and IGFBP-5 in ‘diabetic’ skin models and thus has therapeutic potential.

Wright, Catherine S.; Berends, Rebecca F. [Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA (United Kingdom); Flint, David J. [Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE (United Kingdom); Martin, Patricia E.M., E-mail: Patricia.Martin@gcu.ac.uk [Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA (United Kingdom)

2013-02-15T23:59:59.000Z

4

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide  

SciTech Connect (OSTI)

Sulfur mustard is a potent vesicant that induces inflammation, edema and blistering following dermal exposure. To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT{sup TM}, a commercially available full-thickness human skin equivalent. CEES (100-1000 {mu}M) caused a concentration-dependent increase in pyknotic nuclei and vacuolization in basal keratinocytes; at high concentrations (300-1000 {mu}M), CEES also disrupted keratin filament architecture in the stratum corneum. This was associated with time-dependent increases in expression of proliferating cell nuclear antigen, a marker of cell proliferation, and poly(ADP-ribose) polymerase (PARP) and phosphorylated histone H2AX, markers of DNA damage. Concentration- and time-dependent increases in mRNA and protein expression of eicosanoid biosynthetic enzymes including COX-2, 5-lipoxygenase, microsomal PGE{sub 2} synthases, leukotriene (LT) A{sub 4} hydrolase and LTC{sub 4} synthase were observed in CEES-treated skin equivalents, as well as in antioxidant enzymes, glutathione S-transferases A1-2 (GSTA1-2), GSTA3 and GSTA4. These data demonstrate that CEES induces rapid cellular damage, cytotoxicity and inflammation in full-thickness skin equivalents. These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics.

Black, Adrienne T. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Hayden, Patrick J. [MatTek Corporation, Ashland, MA (United States); Casillas, Robert P. [Battelle Memorial Institute, Columbus, OH (United States); Heck, Diane E. [Environmental Health Sciences, New York Medical College, Valhalla, NY (United States); Gerecke, Donald R. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Sinko, Patrick J. [Pharmaceutics, Rutgers University, Piscataway, NJ (United States); Laskin, Debra L. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Laskin, Jeffrey D., E-mail: jlaskin@eohsi.rutgers.ed [Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ (United States)

2010-12-01T23:59:59.000Z

5

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide  

SciTech Connect (OSTI)

Dermal exposure to the vesicant sulfur mustard causes marked inflammation and tissue damage. Basal keratinocytes appear to be a major target of sulfur mustard. In the present studies, mechanisms mediating skin toxicity were examined using a mouse skin construct model and a full-thickness human skin equivalent (EpiDerm-FT{sup TM}). In both systems, administration of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide (CEES, 100-1000 {mu}M) at the air surface induced mRNA and protein expression of heat shock proteins 27 and 70 (Hsp27 and Hsp70). CEES treatment also resulted in increased expression of caveolin-1, the major structural component of caveolae. Immunohistochemistry revealed that Hsp27, Hsp70 and caveolin-1 were localized in basal and suprabasal layers of the epidermis. Caveolin-1 was also detected in fibroblasts in the dermal component of the full thickness human skin equivalent. Western blot analysis of caveolar membrane fractions isolated by sucrose density centrifugation demonstrated that Hsp27 and Hsp70 were localized in caveolae. Treatment of mouse keratinocytes with filipin III or methyl-{beta}-cyclodextrin, which disrupt caveolar structure, markedly suppressed CEES-induced Hsp27 and Hsp70 mRNA and protein expression. CEES treatment is known to activate JNK and p38 MAP kinases; in mouse keratinocytes, inhibition of these enzymes suppressed CEES-induced expression of Hsp27 and Hsp70. These data suggest that MAP kinases regulate Hsp 27 and Hsp70; moreover, caveolae-mediated regulation of heat shock protein expression may be important in the pathophysiology of vesicant-induced skin toxicity.

Black, Adrienne T. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Hayden, Patrick J. [MatTek Corporation, Ashland, MA (United States); Casillas, Robert P. [Battelle Memorial Institute, Columbus, OH (United States); Heck, Diane E. [Environmental Health, New York Medical College, Valhalla, NY (United States); Gerecke, Donald R. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Sinko, Patrick J. [Pharmaceutics, Rutgers University, Piscataway, NJ (United States); Laskin, Debra L. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Laskin, Jeffrey D., E-mail: jlaskin@eohsi.rutgers.edu [Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ (United States)

2011-06-01T23:59:59.000Z

6

The use of ex vivo human skin tissue for genotoxicity testing  

SciTech Connect (OSTI)

As a result of the chemical legislation concerning the registration, evaluation, authorization and restriction of chemicals (REACH), and the Seventh Amendment to the Cosmetics Directive, which prohibits animal testing in Europe for cosmetics, alternative methods for safety evaluation of chemicals are urgently needed. Current in vitro genotoxicity assays are not sufficiently predictive for the in vivo situation, resulting in an unacceptably high number of misleading positives. For many chemicals and ingredients of personal care products the skin is the first site of contact, but there are no in vitro genotoxicity assays available in the skin for additional evaluation of positive or equivocal responses observed in regulatory in vitro genotoxicity assays. In the present study ex vivo human skin tissue obtained from surgery was used for genotoxicity evaluation of chemicals by using the comet assay. Fresh ex vivo human skin tissue was cultured in an air–liquid interface and topically exposed to 20 chemicals, including true positive, misleading positive and true negative genotoxins. Based on the results obtained in the present study, the sensitivity, specificity and accuracy of the ex vivo skin comet assay to predict in vivo genotoxicity were 89%, 90% and 89%, respectively. Donor and experimental variability were mainly reflected in the magnitude of the response and not the difference between the presence and absence of a genotoxic response. The present study indicates that human skin obtained from surgery is a promising and robust model for safety evaluation of chemicals that are in direct contact with the skin. -- Highlights: ? We use human skin obtained from surgery for genotoxicity evaluation of chemicals. ? We use the comet assay as parameter for genotoxicity in ex vivo human skin. ? Sensitivity, specificity and accuracy to predict in vivo genotoxins are determined. ? Sensitivity, specificity and accuracy are 89%, 90% and 90%, respectively. ? The method is suitable for evaluation of chemicals that are in contact with skin.

Reus, Astrid A.; Usta, Mustafa [TNO Triskelion BV, Utrechtseweg 48, 3704 HE, Zeist (Netherlands)] [TNO Triskelion BV, Utrechtseweg 48, 3704 HE, Zeist (Netherlands); Krul, Cyrille A.M., E-mail: cyrille.krul@tno.nl [TNO, Utrechtseweg 48, 3704 HE Zeist (Netherlands)

2012-06-01T23:59:59.000Z

7

E-Print Network 3.0 - aged human skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

skin-color to track human body. In this paper, we discuss... on human faces. Using skin color as a feature ... Source: Yang, Jie - Human Computer Interaction Institute & School...

8

E-Print Network 3.0 - aging human skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

skin-color to track human body. In this paper, we discuss... on human faces. Using skin color as a feature ... Source: Yang, Jie - Human Computer Interaction Institute & School...

9

Low power cw-laser signatures on human skin  

SciTech Connect (OSTI)

Impact of cw laser radiation on autofluorescence features of human skin is studied. Two methods of autofluorescence detection are applied: the spectral method with the use of a fibreoptic probe and spectrometer for determining the autofluorescence recovery kinetics at a fixed skin area of {approx}12 mm{sup 2}, and the multispectral visualisation method with the use of a multispectral imaging camera for visualising long-term autofluorescence changes in a skin area of {approx}4 cm{sup 2}. The autofluorescence recovery kinetics after preliminary laser irradiation is determined. Skin autofluorescence images with visible long-term changes - 'signatures' of low power laser treatment are acquired. (application of lasers and laser-optical methods in life sciences)

Lihachev, A; Lesinsh, J; Jakovels, D; Spigulis, J [Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga (Latvia)

2011-01-24T23:59:59.000Z

10

In vitro dermal absorption of pyrethroid pesticides in human and rat skin  

SciTech Connect (OSTI)

Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment.

Hughes, Michael F., E-mail: hughes.michaelf@epa.go [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Edwards, Brenda C. [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2010-07-15T23:59:59.000Z

11

A study of heat distribution in human skin: use of Infrared Thermography  

E-Print Network [OSTI]

A study of heat distribution in human skin: use of Infrared Thermography Domoina Ratovoson, Franck of this study is to be able to act quickly on body burns, to avoid propagating lesions due to heat diffusion the temperature change using an infra-red camera. Blood circulation in the veins was seen to clearly influence

Paris-Sud XI, Université de

12

Confocal Microscopy for Modeling Electron Microbeam Irradiation of Skin  

SciTech Connect (OSTI)

For radiation exposures employing targeted sources such as particle microbeams, the deposition of energy and dose will depend on the spatial heterogeneity of the spample. Although cell structural variations are relatively minor for two-dimensional cell cultures, they can vary significantly for fully differential tissues. Employing high-resolution confocal microscopy, we have determined the spatial distribution, size, and shape of epidermal kerantinocyte nuclei for the full-thickness EpiDerm skin model (MatTek, Ashland, VA). Application of these data to claculate the microdosimetry and microdistribution of energy deposition by an electron microbeam is discussed.

Miller, John H.; Chrisler, William B.; Wang, Xihai; Sowa, Marianne B.

2011-08-01T23:59:59.000Z

13

Light scattering by a rough surface of human skin. 1. The luminance factor of reflected light  

SciTech Connect (OSTI)

Based on the analytical solution of Maxwell's equations, we have studied the angular structure of the luminance factor of light reflected by the rough skin surface with large-scale relief elements, illuminated by a directed radiation beam incident at an arbitrary angle inside or outside the medium. The parameters of the surface inhomogeneities are typical of human skin. The calculated angular dependences are interpreted from the point of view of the angular distribution function of micro areas. The results obtained can be used for solving direct and inverse problems in biomedical optics, in particular for determining the depth of light penetration into a biological tissue, for studying the light action spectra on tissue chromophores under the in vivo conditions, for developing diagnostic methods of structural and biophysical parameters of a medium, and for optimising the mechanisms of interaction of light with biological tissues under their noninvasive irradiation through skin. (biomedical optics)

Barun, V V [Belarusian State University of Informatics and Radioelectronics, Minsk (Belarus); Ivanov, A P [B.I.Stepanov Institute of Physics, National Academy of Sciences of Belarus, Minsk (Belarus)

2013-08-31T23:59:59.000Z

14

Simulation of Electron-Beam Irradiation of Skin Tissue Model  

SciTech Connect (OSTI)

Monte Carlo simulation of electrons stopping in liquid water was used to model the penetration and dose distribution of electron beams incident on the full-thickness EpiDermTM skin model (MatTek, Ashland, VA). This 3D tissue model has a fully developed basement membrane separating an epidermal layer of keratinocytes in various stages of differentiation from a dermal layer of fibroblast embedded in collagen. The simulations were motivated by a desire to selectively expose the epidermal layer to low linear-energy-transfer (LET) radiation in the presence of a non-irradiated dermal layer. Using the variable energy electron microbeam at the Pacific Northwest National Laboratory (PNNL) as a model of device characteristics and irradiation geometry, we find that at the highest beam energy available (90 keV), the estimated 90th percentile of penetration remains in the epidermal layer. To investigate the depth-dose distribution, we calculated lineal energy spectra for 10um thick layers near the 10th, 50th, and 90th percentile of penetration by the 90 keV electron beam. Biphasic spectra showed an increasing component of "stoppers" with increasing depth. Despite changes in the lineal energy spectra, the main effect on dose deposition with increasing depth is the screening effect of tissue above the layer of interest.

Miller, John H.; Suleiman, Atef; Chrisler, William B.; Sowa, Marianne B.

2011-01-03T23:59:59.000Z

15

Modelling and simulation of skin-stretch-caused motion artefacts in single-channel ECG signal  

E-Print Network [OSTI]

Modelling and simulation of skin-stretch-caused motion artefacts in single-channel ECG signal in better understanding of artefacts in ECG and in developing model-based techniques for cleaning or interpreting noisy ECG signals. This work com- bines existing experimental results from the field of skin

Hamburg,.Universität

16

Green tea polyphenol, (?)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting ?-catenin signaling  

SciTech Connect (OSTI)

The green tea polyphenol, (?)-epigallocatechin-3-gallate (EGCG), has been shown to have anti-carcinogenic effects in several skin tumor models, and efforts are continued to investigate the molecular targets responsible for its cytotoxic effects to cancer cells. Our recent observation that ?-catenin is upregulated in skin tumors suggested the possibility that the anti-skin carcinogenic effects of EGCG are mediated, at least in part, through its effects on ?-catenin signaling. We have found that treatment of the A431 and SCC13 human skin cancer cell lines with EGCG resulted in reduced cell viability and increased cell death and that these cytotoxic effects were associated with inactivation of ?-catenin signaling. Evidence of EGCG-induced inactivation of ?-catenin included: (i) reduced accumulation of nuclear ?-catenin; (ii) enhanced levels of casein kinase1?, reduced phosphorylation of glycogen synthase kinase-3?, and increased phosphorylation of ?-catenin on critical serine{sup 45,33/37} residues; and (iii) reduced levels of matrix metalloproteinase (MMP)-2 and MMP-9, which are down-stream targets of ?-catenin. Treatment of cells with prostaglandin E2 (PGE{sub 2}) enhanced the accumulation of ?-catenin and enhanced ?-catenin signaling. Treatment with either EGCG or an EP2 antagonist (AH6809) reduced the PGE{sub 2}-enhanced levels of cAMP, an upstream regulator of ?-catenin. Inactivation of ?-catenin by EGCG resulted in suppression of cell survival signaling proteins. siRNA knockdown of ?-catenin in A431 and SCC13 cells reduced cell viability. Collectively, these data suggest that induction of cytotoxicity in skin cancer cells by EGCG is mediated by targeting of ?-catenin signaling and that the ?-catenin signaling is upregulated by inflammatory mediators. - Highlights: • EGCG inhibits cancer cell viability through inactivation of ?-catenin signaling. • Inactivation of ?-catenin involves the downregulation of inflammatory mediators. • EGCG inactivates ?-catenin in skin cancer cells by inhibition of cAMP and PGE{sub 2}. • siRNA knockdown of ?-catenin or COX-2 reduces the viability of cancer cells.

Singh, Tripti [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Katiyar, Santosh K., E-mail: skatiyar@uab.edu [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Birmingham Veterans Affairs Medical Center, Birmingham, AL 35233 (United States)

2013-12-01T23:59:59.000Z

17

06241 Abstracts Collection Human Motion -Understanding, Modeling,  

E-Print Network [OSTI]

06241 Abstracts Collection Human Motion - Understanding, Modeling, Capture and Animation. 13th Summary Human Motion - Understanding, Modeling, Capture and Animation. 13th Workshop Reinhard Klette 06241 Human Motion - Understanding, Modeling, Capture and Animation. 13th Workshop "Theoretical

18

Relevance of in vivo models in melanoma skin cancer  

SciTech Connect (OSTI)

A discussion of possible wavelength dependence of induction of cutaneous malignant melanoma (CMM) is provided. Strengths and weaknesses of various experimental approaches to better understanding of the prevalence of CMM in different human populations including latitude effects are compared. Further the advantages and limitations of the use of the laboratory opossum (Monodelphis domestic), transgenic mice containing SV40 ongogene sequences under tyrosinase promoter control, and a backcross hybrid fish of the genus Xenophorus are contrasted.

Setlow, R.B.

1995-12-31T23:59:59.000Z

19

alternative skin model: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

recognition 1. Charl Van Heerden; Johan Schalkwyk; Brian Strope; Google Inc 54 A new alternative model to dark energy Astrophysics (arXiv) Summary: The recent observations of...

20

Demonstration of tyrosinase in the vitiligo skin of human beings by a sensitive fluorometric method as well as by 14C(U)-L-tyrosine incorporation into melanin  

SciTech Connect (OSTI)

Tyrosinase activity (Monophenol, dihydroxyphenylalanine: oxygen oxidoreductase EC 1.14.18.1) in vitiligo and normal epidermal homogenates of skin from human beings was measured by estimating beta 3,4-dihydroxyphenylalanine (dopa) by a highly sensitive fluorometric method described in this paper. The tyrosine activity in the vitiligo skin was about 4 to 37% of corresponding normal skin. The activity of tyrosinase in normal human skin from different individuals and from different regions of the body was in the range of 4 to 140 picomoles of beta 3,4-dihydroxyphenylalanine formed per min/mg protein of epidermal homogenate. The enzyme from vitiligo and normal skin was severely inhibited by substance(s) of low molecular weight. The enzyme exhibits a lag of about 4 hr in the absence of added beta 3,4-dihydroxyphenylalanine and 1 hr in presence of 5 microM dopa. Tyrosinase from the normal and vitiligo skin was inhibited by excess concentration of tyrosine. The homogenates from vitiligo skin could synthesize melanin from C14(U)-L-Tyrosine. The rate of tyrosine incorporation into melanin by the epidermal homogenates is increased by 3,4-dihydroxyphenylalanine (dopa) disproportionate to its effect on tyrosinase activity. Based on the data presented in this paper it is concluded that melanocytes are present in the vitiligo skin. A tentative hypothesis is put forward to explain the lack of melanin synthesis by the vitiligo skin under in vivo conditions, although melanocytes are present.

Husain, I.; Vijayan, E.; Ramaiah, A.; Pasricha, J.S.; Madan, N.C.

1982-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

E-Print Network 3.0 - adult human dermis Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering 3 Developing a predictive model of human skin colouring Symon D'Oyly Cotton Summary: Developing a predictive model of human skin colouring Symon D'Oyly Cotton Ela...

22

Deformable human body model development  

SciTech Connect (OSTI)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). A Deformable Human Body Model (DHBM) capable of simulating a wide variety of deformation interactions between man and his environment has been developed. The model was intended to have applications in automobile safety analysis, soldier survivability studies and assistive technology development for the disabled. To date, we have demonstrated the utility of the DHBM in automobile safety analysis and are currently engaged in discussions with the U.S. military involving two additional applications. More specifically, the DHBM has been incorporated into a Virtual Safety Lab (VSL) for automobile design under contract to General Motors Corporation. Furthermore, we have won $1.8M in funding from the U.S. Army Medical Research and Material Command for development of a noninvasive intracranial pressure measurement system. The proposed research makes use of the detailed head model that is a component of the DHBM; the project duration is three years. In addition, we have been contacted by the Air Force Armstrong Aerospace Medical Research Laboratory concerning possible use of the DHBM in analyzing the loads and injury potential to pilots upon ejection from military aircraft. Current discussions with Armstrong involve possible LANL participation in a comparison between DHBM and the Air Force Articulated Total Body (ATB) model that is the current military standard.

Wray, W.O.; Aida, T.

1998-11-01T23:59:59.000Z

23

Human Muscle Fatigue Model in Dynamic Motions  

E-Print Network [OSTI]

Human Muscle Fatigue Model in Dynamic Motions Ruina Ma, Damien Chablat, Fouad Bennis, and Liang Ma Abstract Human muscle fatigue is considered to be one of the main reasons for Musculoskeletal Disorder (MSD). Recent models have been introduced to define muscle fatigue for static postures. However, the main

Boyer, Edmond

24

Skin flicks  

E-Print Network [OSTI]

The written and artistic part of this thesis are both separated into the two categories of "SKIN" and "FLICKS". The Artistic part of my thesis consists of five artificial skins made on my body, and a series of video tapes ...

Orth, Margaret A. (Margaret Ann), 1964-

1993-01-01T23:59:59.000Z

25

Mesh Resolution Augmentation using 3D Skin Bank Won-Sook Lee*  

E-Print Network [OSTI]

on a 100-micron resolution scan of plaster cast molds of the actors' faces. Human skin was modeled using, as shown in Figure 1. Each individual is presented with closed eyes and mouth due to the use of plaster

Lee, WonSook

26

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating  

E-Print Network [OSTI]

, is generated under conditions known as risk factors for AD, including stroke and traumatic head injury. BK B2 increases I/L B2 BK receptors in AD skin fibroblasts In established human fetal lung fibroblast models of protein kinase C (PKC). We now show that skin fibro- blasts of patients with AD developing around age 35

Steinbach, Joe Henry

27

Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro  

SciTech Connect (OSTI)

Lymphatic vessels play an important role in tissue fluid homeostasis, intestinal fat absorption and immunosurveillance. Furthermore, they are involved in pathologic conditions, such as tumor cell metastasis and chronic inflammation. In comparison to blood vessels, the molecular phenotype of lymphatic vessels is less well characterized. Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as compared to blood vascular endothelial cells. Here, we have confirmed these results at the protein level, using Western blot and FACS analysis. Immunofluorescence performed on human skin confirmed that CAR is expressed at detectable levels in lymphatic vessels, but not in blood vessels. To address the functional significance of CAR expression, we modulated CAR expression levels in cultured LECs in vitro by siRNA- and vector-based transfection approaches. Functional assays performed with the transfected cells revealed that CAR is involved in distinct cellular processes in LECs, such as cell adhesion, migration, tube formation and the control of vascular permeability. In contrast, no effect of CAR on LEC proliferation was observed. Overall, our data suggest that CAR stabilizes LEC-LEC interactions in the skin and may contribute to lymphatic vessel integrity.

Vigl, Benjamin; Zgraggen, Claudia; Rehman, Nadia; Banziger-Tobler, Nadia E.; Detmar, Michael [Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, CH-8093 Zurich (Switzerland); Halin, Cornelia [Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, CH-8093 Zurich (Switzerland)], E-mail: cornelia.halin@pharma.ethz.ch

2009-01-15T23:59:59.000Z

28

MODELING HUMAN RELIABILITY ANALYSIS USING MIDAS  

SciTech Connect (OSTI)

This paper summarizes an emerging collaboration between Idaho National Laboratory and NASA Ames Research Center regarding the utilization of high-fidelity MIDAS simulations for modeling control room crew performance at nuclear power plants. The key envisioned uses for MIDAS-based control room simulations are: (i) the estimation of human error with novel control room equipment and configurations, (ii) the investigative determination of risk significance in recreating past event scenarios involving control room operating crews, and (iii) the certification of novel staffing levels in control rooms. It is proposed that MIDAS serves as a key component for the effective modeling of risk in next generation control rooms.

Ronald L. Boring; Donald D. Dudenhoeffer; Bruce P. Hallbert; Brian F. Gore

2006-05-01T23:59:59.000Z

29

Human walking model predicts joint mechanics, electromyography and mechanical economy  

E-Print Network [OSTI]

In this paper, we present an under-actuated model of human walking, comprising only a soleus muscle and flexion/extension monoarticular hip muscles. The remaining muscle groups of the human leg are modeled using quasi-passive, ...

Endo, Ken

30

On the Use of Human Mobility Proxies for Modeling Epidemics  

E-Print Network [OSTI]

Human mobility is a key component of large-scale spatial-transmission models of infectious diseases. Correctly modeling and quantifying human mobility is critical for improving epidemic control, but may be hindered by data ...

Tizzoni, Michele

31

Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde  

SciTech Connect (OSTI)

The number of studies involved in the development of in vitro skin sensitization tests has increased since the adoption of the EU 7th amendment to the cosmetics directive proposing to ban animal testing for cosmetic ingredients by 2013. Several studies have recently demonstrated that sensitizers induce a relevant up-regulation of activation markers such as CD86, CD54, IL-8 or IL-1{beta} in human myeloid cell lines (e.g., U937, MUTZ-3, THP-1) or in human peripheral blood monocyte-derived dendritic cells (PBMDCs). The present study aimed at the identification of new dendritic cell activation markers in order to further improve the in vitro evaluation of the sensitizing potential of chemicals. We have compared the gene expression profiles of PBMDCs and the human cell line MUTZ-3 after a 24-h exposure to the moderate sensitizer cinnamaldehyde. A list of 80 genes modulated in both cell types was obtained and a set of candidate marker genes was selected for further analysis. Cells were exposed to selected sensitizers and non-sensitizers for 24 h and gene expression was analyzed by quantitative real-time reverse transcriptase-polymerase chain reaction. Results indicated that PIR, TRIM16 and two Nrf2-regulated genes, CES1 and NQO1, are modulated by most sensitizers. Up-regulation of these genes could also be observed in our recently published DC-activation test with U937 cells. Due to their role in DC activation, these new genes may help to further refine the in vitro approaches for the screening of the sensitizing properties of a chemical.

Python, Francois [Experimental Product Safety, Procter and Gamble Co., Cosmital SA, Marly (Switzerland); Goebel, Carsten [Product Safety, Human Safety Assessment, Procter and Gamble Service GmbH, Darmstadt (Germany); Aeby, Pierre [Experimental Product Safety, Procter and Gamble Co., Cosmital SA, Marly (Switzerland)], E-mail: pierre_aeby@bluewin.ch

2009-09-15T23:59:59.000Z

32

Deformable model for 3D intramodal nonrigid breast image registration with fiducial skin markers  

E-Print Network [OSTI]

of FSM, finite element method (FEM) is used to distribute the markers' displacements linearly over with rigid registration technique. Keywords: Intramodal image registration, finite element method, deformable, we developed a finite element method (FEM) deformable breast model to correct motion artifacts

33

Fuzzy Control Strategies in Human Operator and Sport Modeling  

E-Print Network [OSTI]

The motivation behind mathematically modeling the human operator is to help explain the response characteristics of the complex dynamical system including the human manual controller. In this paper, we present two different fuzzy logic strategies for human operator and sport modeling: fixed fuzzy-logic inference control and adaptive fuzzy-logic control, including neuro-fuzzy-fractal control. As an application of the presented fuzzy strategies, we present a fuzzy-control based tennis simulator.

Ivancevic, Tijana T; Markovic, Sasa

2009-01-01T23:59:59.000Z

34

Neutron skins and neutron stars  

SciTech Connect (OSTI)

The neutron-skin thickness of heavy nuclei provides a fundamental link to the equation of state of neutron-rich matter, and hence to the properties of neutron stars. The Lead Radius Experiment ('PREX') at Jefferson Laboratory has recently provided the first model-independence evidence on the existence of a neutron-rich skin in {sup 208}Pb. In this contribution we examine how the increased accuracy in the determination of neutron skins expected from the commissioning of intense polarized electron beams may impact the physics of neutron stars.

Piekarewicz, J. [Department of Physics, Florida State University, Tallahassee, FL 32306-4350 (United States)

2013-11-07T23:59:59.000Z

35

Friction Induced Skin Tags  

E-Print Network [OSTI]

Duplantis KL, Jones BH. Friction blisters. Pathophysiology,Friction Induced Skin Tags Francisco Allegue MD 1 , Carmenetiopathogenic role for friction. Introduction Skin tags (

Allegue, Francisco; Fachal, Carmen; Pérez-Pérez, Lidia

2008-01-01T23:59:59.000Z

36

Human Growth and Body Weight Dynamics: An Integrative Systems Model  

E-Print Network [OSTI]

Quantifying human weight and height dynamics due to growth, aging, and energy balance can inform clinical practice and policy analysis. This paper presents the first mechanism-based model spanning full individual life and ...

Rahmandad, Hazhir

37

A multisensory observer model for human spatial orientation perception  

E-Print Network [OSTI]

Quantitative "observer" models for spatial orientation and eye movements have been developed based on 1-G data from humans and animals (e.g. Oman 1982, 1991, Merfeld, et al 1993, 2002; Haslwanter 2000, Vingerhoets 2006). ...

Newman, Michael C. (Michael Charles)

2009-01-01T23:59:59.000Z

38

Efficient elasticity for character skinning with contact and collisions Aleka McAdams1,3  

E-Print Network [OSTI]

-level character skinning system. CR Categories: I.6.8 [Simulation and Modeling]: Types of Simulation--Animation aspect is the production of life-like deformations for soft tissues comprising both humans and animals Animation Studios 2 PDI/DreamWorks 3 University of California, Los Angeles 4 University of Wisconsin

Liblit, Ben

39

Modeling aspects of human memory for scientific study.  

SciTech Connect (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

40

Reading Tea Leaves: How Humans Interpret Topic Models  

E-Print Network [OSTI]

Reading Tea Leaves: How Humans Interpret Topic Models Jonathan Chang Jordan Boyd-Graber Sean, Blei Reading Tea Leaves #12;Topic Models in a Nutshell From an input corpus words to topics Forget Red Light, Green Light: A 2-Tone L.E.D. to Simplify Screens Corpus Chang, Boyd-Graber, Wang, Gerrish

Boyd-Graber, Jordan

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Human Mental Models of Humanoid Robots* Sau-lai Lee Sara Kiesler  

E-Print Network [OSTI]

Human Mental Models of Humanoid Robots* Sau-lai Lee Sara Kiesler Human Computer Interaction ground of understanding between the two. In two experiments modelled after human-human studies we robot emits a human's voice), their mental model of the system's behavior may approach their mental

Kiesler, Sara

42

Modeling and simulation of stable human locomotion using five degree-of-freedom gait model  

E-Print Network [OSTI]

Human locomotion involves a highly sophisticated and complex locomotive system. In order to understand how models of such system are built, it is useful to consider the meaning and implication of modeling and simulation as an attempt to represent...

Viswanathan, Vanisri

2001-01-01T23:59:59.000Z

43

Human performance modeling for system of systems analytics :soldier fatigue.  

SciTech Connect (OSTI)

The military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives as can be seen in the Department of Defense's (DoD) Defense Modeling and Simulation Office's (DMSO) Master Plan (DoD 5000.59-P 1995). To this goal, the military is currently spending millions of dollars on programs devoted to HPM in various military contexts. Examples include the Human Performance Modeling Integration (HPMI) program within the Air Force Research Laboratory, which focuses on integrating HPMs with constructive models of systems (e.g. cockpit simulations) and the Navy's Human Performance Center (HPC) established in September 2003. Nearly all of these initiatives focus on the interface between humans and a single system. This is insufficient in the era of highly complex network centric SoS. This report presents research and development in the area of HPM in a system-of-systems (SoS). Specifically, this report addresses modeling soldier fatigue and the potential impacts soldier fatigue can have on SoS performance.

Lawton, Craig R.; Campbell, James E.; Miller, Dwight Peter

2005-10-01T23:59:59.000Z

44

Electron contamination modeling and skin dose in 6 MV longitudinal field MRIgRT: Impact of the MRI and MRI fringe field  

SciTech Connect (OSTI)

Purpose: In recent times, longitudinal field MRI-linac systems have been proposed for 6 MV MRI-guided radiotherapy (MRIgRT). The magnetic field is parallel with the beam axis and so will alter the transport properties of any electron contamination particles. The purpose of this work is to provide a first investigation into the potential effects of the MR and fringe magnetic fields on the electron contamination as it is transported toward a phantom, in turn, providing an estimate of the expected patient skin dose changes in such a modality. Methods: Geant4 Monte Carlo simulations of a water phantom exposed to a 6 MV x-ray beam were performed. Longitudinal magnetic fields of strengths between 0 and 3 T were applied to a 30 x 30 x 20 cm{sup 3} phantom. Surrounding the phantom there is a region where the magnetic field is at full MRI strength, consistent with clinical MRI systems. Beyond this the fringe magnetic field entering the collimation system is also modeled. The MRI-coil thickness, fringe field properties, and isocentric distance are varied and investigated. Beam field sizes of 5 x 5, 10 x 10, 15 x 15 and 20 x 20 cm{sup 2} were simulated. Central axis dose, 2D virtual entry skin dose films, and 70 {mu}m skin depth doses were calculated using high resolution scoring voxels. Results: In the presence of a longitudinal magnetic field, electron contamination from the linear accelerator is encouraged to travel almost directly toward the patient surface with minimal lateral spread. This results in a concentration of electron contamination within the x-ray beam outline. This concentration is particularly encouraged if the fringe field encompasses the collimation system. Skin dose increases of up to 1000% were observed for certain configurations and increases above Dmax were common. In nonmagnetically shielded cases, electron contamination generated from the jaw faces and air column is trapped and propagated almost directly to the phantom entry region, giving rise to intense dose hot spots inside the x-ray treatment field. These range up to 1000% or more of Dmax at the CAX, depending on field size, isocenter, and coil thickness. In the case of a fully magnetically shielded collimation system and the lowest MRI field of 0.25 T, the entry skin dose is expected to increase to at least 40%, 50%, 65%, and 80% of Dmax for 5 x 5, 10 x 10, 15 x 15, and 20 x 20 cm{sup 2}, respectively. Conclusions: Electron contamination from the linac head and air column may cause considerable skin dose increases or hot spots at the beam central axis on the entry side of a phantom or patient in longitudinal field 6 MV MRIgRT. This depends heavily on the properties of the magnetic fringe field entering the linac beam collimation system. The skin dose increase is also related to the MRI-coil thickness, the fringe field, and the isocenter distance of the linac. The results of this work indicate that the properties of the MRI fringe field, electron contamination production, and transport must be considered carefully during the design stage of a longitudinal MRI-linac system.

Oborn, B. M.; Metcalfe, P. E.; Butson, M. J.; Rosenfeld, A. B.; Keall, P. J. [Illawarra Cancer Care Centre (ICCC), Wollongong, NSW 2500 (Australia) and Centre for Medical Radiation Physics (CMRP), University of Wollongong, Wollongong, NSW 2500 (Australia); Centre for Medical Radiation Physics (CMRP), University of Wollongong, Wollongong, NSW 2500 (Australia); Illawarra Cancer Care Centre (ICCC), Wollongong, NSW 2500 (Australia) and Centre for Medical Radiation Physics (CMRP), University of Wollongong, Wollongong, NSW 2500 (Australia); Centre for Medical Radiation Physics (CMRP), University of Wollongong, Wollongong, NSW 2500 (Australia); Sydney Medical School, University of Sydney, NSW 2006 (Australia)

2012-02-15T23:59:59.000Z

45

A stochastic evolutionary model for capturing human dynamics  

E-Print Network [OSTI]

The recent interest in human dynamics has led researchers to investigate the stochastic processes that explain human behaviour in various contexts. Here we propose a generative model to capture the dynamics of survival analysis, traditionally employed in clinical trials and reliability analysis in engineering. We derive a general solution for the model in the form of a product, and then a continuous approximation to the solution via the renewal equation describing age-structured population dynamics. This enables us to model a wide rage of survival distributions, according to the choice of the mortality distribution. We provide empirical evidence for the validity of the model from a longitudinal data set of popular search engine queries over 114 months, showing that the survival function of these queries is closely matched by the solution for our model with power-law mortality.

Fenner, Trevor; Loizou, George

2015-01-01T23:59:59.000Z

46

A noninvasive skin imaging system Symon Cotton  

E-Print Network [OSTI]

A noninvasive skin imaging system Symon Cotton School of Computer Science, University Of Birmingham arriving at a diagnosis. A previous paper [Cotton and Claridge 1996] presented a model of colour formation­dimensional colour space, is limited to a curved surface [Cotton and Claridge 1996]. As abnormal skin often has a di

Claridge, Ela

47

Sensitivity analysis techniques for models of human behavior.  

SciTech Connect (OSTI)

Human and social modeling has emerged as an important research area at Sandia National Laboratories due to its potential to improve national defense-related decision-making in the presence of uncertainty. To learn about which sensitivity analysis techniques are most suitable for models of human behavior, different promising methods were applied to an example model, tested, and compared. The example model simulates cognitive, behavioral, and social processes and interactions, and involves substantial nonlinearity, uncertainty, and variability. Results showed that some sensitivity analysis methods create similar results, and can thus be considered redundant. However, other methods, such as global methods that consider interactions between inputs, can generate insight not gained from traditional methods.

Bier, Asmeret Brooke

2010-09-01T23:59:59.000Z

48

Modeling Human Behavior from Simple Sensors in the Home  

E-Print Network [OSTI]

Modeling Human Behavior from Simple Sensors in the Home Ryan Aipperspach, Elliot Cohen, and John {ryanaip, jfc}@cs.berkeley.edu, emcohen3@berkeley.edu Abstract. Pervasive sensors in the home have a variety of applications including energy minimization, activity monitoring for elders, and tutors

Canny, John

49

Evaluating the Applicability of Current Models of Workload to Peer-based Human-robot Teams  

E-Print Network [OSTI]

-off possibility into a reality. Human Performance Moderator Functions (HPMFs) can be used to predict human. This trend was predicted by the IMPRINT Pro models. These results are the first to indicate that existing Terms Performance, Experimentation, Human Factors Keywords human-robot peer-based teams, human-performance

Zhang, Tao

50

Automatic Modeling of Virtual Humans and Body Clothing Nadia Magnenat-Thalmann, Hyewon Seo, Frederic Cordier  

E-Print Network [OSTI]

Automatic Modeling of Virtual Humans and Body Clothing Nadia Magnenat-Thalmann, Hyewon Seo-mail: {thalmann, seo, cordier}@miralab.unige.ch Abstract Highly realistic virtual human models are rapidly

Cordier, Frederic

51

A Game Theory Based Model of Human Driving with Application to Autonomous and Mixed Driving  

E-Print Network [OSTI]

In this work, I consider the development of a driver model to better understand human drivers’ various behaviors in the upcoming mixed situation of human drivers and autonomous vehicles. For this, my current effort focuses on modeling the driver...

Yoo, Je Hong

2014-08-04T23:59:59.000Z

52

Keywords: Agents, Cellular models, Discrete event simula-tion, DEVS, human agent models, Mediterranean landscape.  

E-Print Network [OSTI]

- plained by climate change or human-caused degradation of the landscape. Finally, by placing model villages, Mediterranean landscape. ABSTRACT The Mediterranean Landscape Dynamics (MEDLAND) pro- ject seeks to better an- other while providing flexibility for either model to be changed in a systematic fashion

53

RIS-M-2349 A MODEL OF HUMAN DECISION MAKING IN COMPLEX SYSTEMS  

E-Print Network [OSTI]

of the operator is to design a INIS Descriptors BEHAVIOR; CONTROL ROOMS; CONTROL SYSTEMS; FLOW MODELS; HUMAN

54

Virtual Human Animation Based on Movement Observation and Cognitive Behavior Models  

E-Print Network [OSTI]

Virtual Human Animation Based on Movement Observation and Cognitive Behavior Models Norman I undertaken by the character, and ffl the internal model of what it means to be human. In order to address. Badler, Diane Chi, Sonu Chopra Center for Human Modeling and Simulation University of Pennsylvania

Badler, Norman I.

55

Computational Human Performance Modeling For Alarm System Design  

SciTech Connect (OSTI)

The introduction of new technologies like adaptive automation systems and advanced alarms processing and presentation techniques in nuclear power plants is already having an impact on the safety and effectiveness of plant operations and also the role of the control room operator. This impact is expected to escalate dramatically as more and more nuclear power utilities embark on upgrade projects in order to extend the lifetime of their plants. One of the most visible impacts in control rooms will be the need to replace aging alarm systems. Because most of these alarm systems use obsolete technologies, the methods, techniques and tools that were used to design the previous generation of alarm system designs are no longer effective and need to be updated. The same applies to the need to analyze and redefine operators’ alarm handling tasks. In the past, methods for analyzing human tasks and workload have relied on crude, paper-based methods that often lacked traceability. New approaches are needed to allow analysts to model and represent the new concepts of alarm operation and human-system interaction. State-of-the-art task simulation tools are now available that offer a cost-effective and efficient method for examining the effect of operator performance in different conditions and operational scenarios. A discrete event simulation system was used by human factors researchers at the Idaho National Laboratory to develop a generic alarm handling model to examine the effect of operator performance with simulated modern alarm system. It allowed analysts to evaluate alarm generation patterns as well as critical task times and human workload predicted by the system.

Jacques Hugo

2012-07-01T23:59:59.000Z

56

Modeling Measuring and Correcting the LCA of theModeling Measuring and Correcting the LCA of the Human EyeHuman Eye  

E-Print Network [OSTI]

of the Human EyeHuman Eye Introduction The eye as an optical system suffers from both longitudinal chromatic.Software modeling of the eye and LCA corrector We designed a two-triplet air-spaced system, using glasses, WA, USA). The chromatic eye model was added to the simulation, and optimization was performed

Ribak, Erez

57

BIOMECHANICAL ANALYSIS OF TWO SIMPLE DYNAMICAL MODELS FOR THE HUMAN GAIT  

E-Print Network [OSTI]

and expenditure energy for the human body in normal walking models. Both models allow us to adapt a vector the adaptability of the subject to the environment in a reactive way . The high complexity of biomechanical modelsBIOMECHANICAL ANALYSIS OF TWO SIMPLE DYNAMICAL MODELS FOR THE HUMAN GAIT J.Finat1 , F.Montoya2

Llanos, Diego R.

58

Models and evaluation of human-machine systems  

E-Print Network [OSTI]

The field of human-machine systems and human-machine interfaces is very multidisciplinary. We have to navigate between the knowledge waves brought by several areas of the human learning: cognitive psychology, artificial ...

Bayout Alvarenga, Marco Antonio

1993-01-01T23:59:59.000Z

59

Physiologically Based Pharmacokinetic (PBPK) Modeling of Benzene in Humans: A Bayesian Approach  

E-Print Network [OSTI]

that are now often used in risk assessment to better extrapolate from experimental animals to humans and from hPhysiologically Based Pharmacokinetic (PBPK) Modeling of Benzene in Humans: A Bayesian Approach for variability among humans, the mathematical model must be integrated into a statistical framework

60

Modeling Human Behavior in the Aftermath of a Hypothetical Improvised Nuclear Detonation  

E-Print Network [OSTI]

on modeling the physical effects of the attack, such as thermal and blast ef- fects, prompt radiationModeling Human Behavior in the Aftermath of a Hypothetical Improvised Nuclear Detonation Nidhi describe a multiagent simulation model of human behavior in the aftermath of a hypothetical, large- scale

Swarup, Samarth

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Sprayed skin turbine component  

DOE Patents [OSTI]

Fabricating a turbine component (50) by casting a core structure (30), forming an array of pits (24) in an outer surface (32) of the core structure, depositing a transient liquid phase (TLP) material (40) on the outer surface of the core structure, the TLP containing a melting-point depressant, depositing a skin (42) on the outer surface of the core structure over the TLP material, and heating the assembly, thus forming both a diffusion bond and a mechanical interlock between the skin and the core structure. The heating diffuses the melting-point depressant away from the interface. Subsurface cooling channels (35) may be formed by forming grooves (34) in the outer surface of the core structure, filling the grooves with a fugitive filler (36), depositing and bonding the skin (42), then removing the fugitive material.

Allen, David B

2013-06-04T23:59:59.000Z

62

Skin friction blistering: computer model.  

E-Print Network [OSTI]

on blisters produced by friction. I. Results of linearDuplantis KL, Jones BH. Friction blisters. Pathophysiology,WA, Sulzberger MB. The friction blister. Mil Med 6. Cortese

Xing, Malcolm; Pan, Ning; Zhong, Wen; Maibach, Howard

2007-01-01T23:59:59.000Z

63

Skin friction blistering: computer model.  

E-Print Network [OSTI]

K. L.Jones, B. H. , Friction blisters. Pathophysiology,and M.B. Sulzberger, The friction blister. Mil Med, 1972.on blisters produced by friction. II. The blister fluid. J

Xing, Malcolm; Pan, Ning; Zhong, Wen; Maibach, Howard

2007-01-01T23:59:59.000Z

64

A phenomenological muscle model to assess history dependent effects in human movement  

E-Print Network [OSTI]

A phenomenological muscle model to assess history dependent effects in human movement C.P. Mc of the history dependent effects. The phenomenological model of stretch-induced force enhancement was dependent

Ben-Yakar, Adela

65

Modeling human risk: Cell & molecular biology in context  

SciTech Connect (OSTI)

It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high dose-rate, whereas in space, with the exception of solar particle events, radiation exposures will be low-dose, low dose-rate; (3) Although it has been established that the virtual absence of gravity in space has a profound effect on human physiology, it is not clear whether these effects will act synergistically with those of radiation exposure. A select panel will evaluate the utilizing experiments and models to accurately predict the risks associated with exposure to HZE particles. Topics of research include cellular and tissue response, health effects associated with radiation damage, model animal systems, and critical markers of Radiation response.

NONE

1997-06-01T23:59:59.000Z

66

A quantum mechanical derivation of the Schwarzschild radius and its quantum correction using a model density distribution: Skin of a black hole  

E-Print Network [OSTI]

Using a single particle density distribution for a system of self-gravitating particles which ultimately forms a black hole, we from a condensed matter point of view derive the Schwarzschild radius and by including the quantum mechanical exchange energy we find a small correction to the Schwarzschild radius, which we designate as the skin of the black hole.

Subodha Mishra

2007-03-16T23:59:59.000Z

67

A generalized 3D inverted pendulum model to represent human normal walking  

E-Print Network [OSTI]

A generalized 3D inverted pendulum model to represent human normal walking Sophie Sakka IRCCy,lacouture}@univ-poitiers.fr Abstract-- This paper compares different inverted pendulum models to represent the stance phase of human adapted to pathological walking as the walking symmetry hypothesis -needed to build classical inverted

Paris-Sud XI, Université de

68

Skin contamination dosimeter  

DOE Patents [OSTI]

A technique and device provides absolute skin dosimetry in real time at multiple tissue depths simultaneously. The device uses a phoswich detector which has multiple scintillators embedded at different depths within a non-scintillating material. A digital pulse processor connected to the phoswich detector measures a differential distribution (dN/dH) of count rate N as function of pulse height H for signals from each of the multiple scintillators. A digital processor computes in real time from the differential count-rate distribution for each of multiple scintillators an estimate of an ionizing radiation dose delivered to each of multiple depths of skin tissue corresponding to the multiple scintillators embedded at multiple corresponding depths within the non-scintillating material.

Hamby, David M. (Corvallis, OR); Farsoni, Abdollah T. (Corvallis, OR); Cazalas, Edward (Corvallis, OR)

2011-06-21T23:59:59.000Z

69

Predictive models of procedural human supervisory control behavior  

E-Print Network [OSTI]

Human supervisory control systems are characterized by the computer-mediated nature of the interactions between one or more operators and a given task. Nuclear power plants, air traffic management and unmanned vehicles ...

Boussemart, Yves, 1980-

2011-01-01T23:59:59.000Z

70

Emotions and Action Selection in an Artificial Life Model of Social Behavior in Non-Human Primates  

E-Print Network [OSTI]

and Stein, 2001a,b]. Our agents are designed to model animal behaviors that humans readily describeEmotions and Action Selection in an Artificial Life Model of Social Behavior in Non-Human Primates behaviors dis- played by colonies of non-human primates. We hope to use this ALife model to support work

Bryson, Joanna J.

71

Putting in perspective human-machine system theory and modeling: from theoretical biology to artifacts  

E-Print Network [OSTI]

there is a strong need of reliability and consistency from modeling, development and life cycle systems. A main and organization from human-machine systems to socio- technical systems especially for safety and life critical methodologies and ergonomics of systems design. Current and future technical developments for enhancing human

Paris-Sud XI, Université de

72

UNCORRECTED 2 Models of natural and human dynamics in forest landscapes  

E-Print Network [OSTI]

protected areas, though they differ in the specifics of vegetation and land 23 use. In the Texas sitesUNCORRECTED PROOF 1 2 Models of natural and human dynamics in forest landscapes: 3 Cross natural and human systems across sites and cultures through a process of simplification and 17 abstraction

Monticino, Michael

73

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model  

E-Print Network [OSTI]

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model K. Lu,1 J. W autoregulation, brain gas ex- change, and their interaction by means of a mathematical model. We have previously of intracranial dynamics. However, their models did not include gas transport in brain tissue and thus can

74

Model of medical supply demand and astronaut health for long-duration human space flight  

E-Print Network [OSTI]

The medical care of space crews is the primary limiting factor in the achievement of long-duration space missions. (Nicogossian 2003) The goal of this thesis was to develop a model of long-duration human space flight ...

Assad, Albert

2009-01-01T23:59:59.000Z

75

A mid-layer model for human reliability analysis : understanding the cognitive causes of human failure events.  

SciTech Connect (OSTI)

The Office of Nuclear Regulatory Research (RES) at the US Nuclear Regulatory Commission (USNRC) is sponsoring work in response to a Staff Requirements Memorandum (SRM) directing an effort to establish a single human reliability analysis (HRA) method for the agency or guidance for the use of multiple methods. As part of this effort an attempt to develop a comprehensive HRA qualitative approach is being pursued. This paper presents a draft of the method's middle layer, a part of the qualitative analysis phase that links failure mechanisms to performance shaping factors. Starting with a Crew Response Tree (CRT) that has identified human failure events, analysts identify potential failure mechanisms using the mid-layer model. The mid-layer model presented in this paper traces the identification of the failure mechanisms using the Information-Diagnosis/Decision-Action (IDA) model and cognitive models from the psychological literature. Each failure mechanism is grouped according to a phase of IDA. Under each phase of IDA, the cognitive models help identify the relevant performance shaping factors for the failure mechanism. The use of IDA and cognitive models can be traced through fault trees, which provide a detailed complement to the CRT.

Shen, Song-Hua (US Nuclear Regulatory Commission, Washington, DC); Chang, James Y. H. (US Nuclear Regulatory Commission, Washington, DC); Boring,Ronald L. (Idaho National Laboratory, Idaho Falls, ID); Whaley, April M. (Idaho National Laboratory, Idaho Falls, ID); Lois, Erasmia (US Nuclear Regulatory Commission, Washington, DC); Hendrickson, Stacey M. Langfitt; Oxstrand, Johanna H. (Vattenfall Ringhals AB, Varobacka, Sweden); Forester, John Alan; Kelly, Dana L. (Idaho National Laboratory, Idaho Falls, ID); Mosleh, Ali (University of Maryland, College Park, MD)

2010-03-01T23:59:59.000Z

76

A Generative Model of Human Hair for Hair Sketching  

E-Print Network [OSTI]

Yu, ”A practical model for hair mutual interactions,” Proc.Interactive multi-resolution hair modeling and editing,”directions (?1, +1) of the hair ?ow on the two sides of the

Hong Chen; Song Chun Zhu

2011-01-01T23:59:59.000Z

77

Modeling Human Neural Development Using Pluripotent Stem Cells  

E-Print Network [OSTI]

Jaenisch R. Treatment of sickle cell anemia mouse model withharboring the mutation for sickle cell disease 20 . Despite

Patterson, Michaela Cyr

2012-01-01T23:59:59.000Z

78

Application of a canine {sup 238}Pu dosimetry model to human bioassay data  

SciTech Connect (OSTI)

Associated with the use of 2{sup 238}Pu in thermoelectric power sources for space probes and power supplies for cardiac devices is the potential for human exposure to {sup 238}Pu, primarily by inhalation. In the event of human internal exposure, a means is needed for assessing the level of intake and calculating radiation doses. Several bioassay/dosimetry models have been developed for {sup 239}Pu. However, results from studies with laboratory animals have indicated that the biokinetics, and therefore the descriptive models, of {sup 238}Pu are significantly different from those for {sup 239}Pu. A canine model accounting for these differences has been applied in this work to urinary excretion data from seven humans occupationally exposed to low levels of an insoluble {sup 238}Pu compound. The modified model provides a good description of the urinary excretion kinetics observed in the exposed humans. The modified model was also used to provide estimates of the initial intakes of {sup 238}Pu for the seven individuals; these estimates ranged from 4.5 nCi (170 Bq) to 87 nCi (3200 Bq). Autopsy data on the amount and distribution of {sup 238}Pu retained in the organs may be used in the future to validate or refute both these estimates and the assumptions used to formulate the human model. Modification of the human model to simulate an injection exposure to {sup 239}Pu gave patterns of retention in the organs and urinary excretion comparable to those seen previously in humans; further modification of the model using fecal data (unavailable for the subjects of this study) is indicated.

Hickman, A.W. Jr. [Florida Univ., Gainesville, FL (United States)

1991-08-01T23:59:59.000Z

79

A Human Performance Modeling System for Process Safety Operations  

E-Print Network [OSTI]

this in the future, as well. When an abnormal process situation occurs, human intervention by responding to the alarm is often the last line of defense before a Safety Instrumented System (SIS) takes action to trip or shut down the system. If SIS takes... need to be followed by a terminal activity (get or put). Table 2. Codes for movement elements (small objects) 25 Movement MOD Body Part Distance Moved M1 1 Finger (hinged at knuckle) 1? M2 2 Hand (hinged at wrist) 2? M3 3 Arm (hinged...

Harputlu, Emrah 1986-

2013-01-02T23:59:59.000Z

80

Graphs of models for exploring design spaces in the engineering of Human Computer Interaction  

E-Print Network [OSTI]

Graphs of models for exploring design spaces in the engineering of Human Computer Interaction +33 (0)4 76 51 48 54 gaelle.calvary@imag.fr ABSTRACT Model Driven Engineering (MDE) has focused creativity in the early phases. Our research aims at stretching MDE all over the design process including

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Modeling hematologic malignancies and their treatment in humanized mice  

E-Print Network [OSTI]

Approximately 10% of all cancer deaths in the United States are due to neoplasms of the hematopoietic system, such as leukemias and lymphomas. Genetically engineered mouse models of these diseases have yielded invaluable ...

Leskov, Ilya, Ph. D. Massachusetts Institute of Technology

2010-01-01T23:59:59.000Z

82

Surety of human elements of high consequence systems: An organic model  

SciTech Connect (OSTI)

Despite extensive safety analysis and application of safety measures, there is a frequent lament, ``Why do we continue to have accidents?'' Two breakdowns are prevalent in risk management and prevention. First, accidents result from human actions that engineers, analysts and management never envisioned and second, controls, intended to preclude/mitigate accident sequences, prove inadequate. This paper addresses the first breakdown, the inability to anticipate scenarios involving human action/inaction. The failure of controls has been addressed in a previous publication (Forsythe and Grose, 1998). Specifically, this paper presents an approach referred to as surety. The objective of this approach is to provide high levels of assurance in situations where potential system failure paths cannot be fully characterized. With regard to human elements of complex systems, traditional approaches to human reliability are not sufficient to attain surety. Consequently, an Organic Model has been developed to account for the organic properties exhibited by engineered systems that result from human involvement in those systems.

FORSYTHE,JAMES C.; WENNER,CAREN A.

2000-04-25T23:59:59.000Z

83

Human intake fraction of toxic pollutants: a model comparison between caltox and uses-lca  

SciTech Connect (OSTI)

In Life Cycle Assessment and Comparative Risk Assessment potential human exposure to toxic pollutants can be expressed as the human intake fraction (iF), representing the fraction of the quantity emitted that enters the human population. To assess model uncertainty in the human intake fraction, ingestion and inhalation iFs of 367 substances emitted to air and freshwater were calculated with two commonly applied multi-media fate and exposure models, CalTOX and USES-LCA. Comparison of the model outcomes reveal that uncertainty in the ingestion iFs was up to a factor of 70. The uncertainty in the inhalation iFs was up to a factor of 865,000. The comparison showed that relatively few model differences account for the uncertainties found. An optimal model structure in the calculation of human intake fractions can be achieved by including (1) rain and no-rain scenarios, (2) a continental sea water compartment, (3) drinking water purification, (4) pH-correction of chemical properties, and (5) aerosol-associated deposition on plants. Finally, vertical stratification of the soil compartment combined with a chemical-dependent soil depth may be considered in future intake fraction calculations.

Huijbregts, Mark A.J.; Geelen, Loes M.J.; Hertwich, Edgar G.; McKone, Thomas E.; van de Meent, Dik

2004-01-06T23:59:59.000Z

84

Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans  

SciTech Connect (OSTI)

ABSTRACT 1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver and kidney damage at sufficiently high exposure levels. Two physiologically-based pharmacokinetic (PBPK) models of 1,4-dioxane and its major metabolite, hydroxyethoxyacetic acid (HEAA), were published in 1990. These models have uncertainties and deficiencies that could be addressed and the model strengthened for use in a contemporary cancer risk assessment for 1,4-dioxane. Studies were performed to fill data gaps and reduce uncertainties pertaining to the pharmacokinetics of 1,4-dioxane and HEAA in rats, mice, and humans. Three types of studies were performed:partition coefficient measurements, blood time course in mice, and in vitro pharmacokinetics using rat, mouse, and human hepatocytes. Updated PBPK models were developed based on these new data and previously available data. The optimized rate of metabolism for the mouse was significantly higher than the value previously estimated. The optimized rat kinetic parameters were similar to those in the 1990 models. Only two human studies were identified. Model predictions were consistent with one study, but did not fit the second as well. In addition, a rat nasal exposure was completed. The results confirmed water directly contacts rat nasal tissues during drinking water under bioassays. Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments.

Sweeney, Lisa M.; Thrall, Karla D.; Poet, Torka S.; Corley, Rick; Weber, Thomas J.; Locey, B. J.; Clarkson, Jacquelyn; Sager, S.; Gargas, M. L.

2008-01-01T23:59:59.000Z

85

Sensitive skins and somatic processing for affective and sociable robots based upon a somatic alphabet approach  

E-Print Network [OSTI]

The sense of touch is one of the most important senses of the human body. This thesis describes the biologically inspired design of "sensitive skins" for two different robotic platforms: Leonardo, a high degree-of-freedom, ...

Stiehl, Walter Daniel, 1980-

2005-01-01T23:59:59.000Z

86

Detecting pornographic images by localizing skin Sotiris Karavarsamisa  

E-Print Network [OSTI]

specialized sub- classes, namely "bikini" / "porn" and "skin" / "non-skin", respectively. The extracted

Blekas, Konstantinos

87

Human-robot cross-training: Computational formulation, modeling and evaluation of a human team training strategy  

E-Print Network [OSTI]

We design and evaluate human-robot cross-training, a strategy widely used and validated for effective human team training. Cross-training is an interactive planning method in which a human and a robot iteratively switch ...

Nikolaidis, Stefanos

88

Integrating digital human modeling into virtual environment for ergonomic oriented design  

E-Print Network [OSTI]

Virtual human simulation integrated into virtual reality applications is mainly used for virtual representation of the user in virtual environment or for interactions between the user and the virtual avatar for cognitive tasks. In this paper, in order to prevent musculoskeletal disorders, the integration of virtual human simulation and VR application is presented to facilitate physical ergonomic evaluation, especially for physical fatigue evaluation of a given population. Immersive working environments are created to avoid expensive physical mock-up in conventional evaluation methods. Peripheral motion capture systems are used to capture natural movements and then to simulate the physical operations in virtual human simulation. Physical aspects of human's movement are then analyzed to determine the effort level of each key joint using inverse kinematics. The physical fatigue level of each joint is further analyzed by integrating a fatigue and recovery model on the basis of physical task parameters. All the pr...

Ma, Liang; Bennis, Fouad; Hu, Bo; Zhang, Wei

2010-01-01T23:59:59.000Z

89

A critical comparison of human face rendering techniques  

E-Print Network [OSTI]

Human skin exhibits complex light reflectance properties that make it difficult to render realistically. In recent years, many techniques have been introduced to render skin, with varying degrees of complexity and realism. ...

Arizpe, Arturo Andrew

2006-01-01T23:59:59.000Z

90

Human Leg Model Predicts Ankle Muscle-Tendon Morphology, State, Roles and Energetics in Walking  

E-Print Network [OSTI]

Human Leg Model Predicts Ankle Muscle-Tendon Morphology, State, Roles and Energetics in Walking to be established. Here we develop a computational framework to address how the ankle joint actuation problem-tendon morphology and neural activations enable a metabolically optimal realization of biological ankle mechanics

Herr, Hugh

91

A COMPARISON BETWEEN TWO SIMPLIFIED DYNAMICAL MODELS FOR THE HUMAN GAIT  

E-Print Network [OSTI]

A COMPARISON BETWEEN TWO SIMPLIFIED DYNAMICAL MODELS FOR THE HUMAN GAIT A.Ortega 1 , F.Montoya 1 and J.Finat 2 , MoBiVA Group. 1 ETS Ing. Industrial, Paseo del Cauce, Univ. Valladolid, 47011 Valladolid to a passive approach to maintain the upright position and locomotion with a view to their applications

Llanos, Diego R.

92

Homogenization of a Multiscale Viscoelastic Model with Nonlocal Damping, Application to the Human Lungs  

E-Print Network [OSTI]

]. Our motiva- tion concerns the mathematical modeling of the human respiratory system and our interest an abstract convergence condition on this nonlocal operator. We derive some mechanical properties of the limit of air through the respiratory tract from its ex- ternal entries, the nose and the mouth. During

Paris-Sud XI, Université de

93

Modeling the dynamics of human hair cycles by a follicular automaton  

E-Print Network [OSTI]

Modeling the dynamics of human hair cycles by a follicular automaton J. Halloy*, B. A. Bernard , G University of Brussels, Brussels, Belgium, May 15, 2000 (received for review December 23, 1999) The hair correspond, respectively, to hair growth, arrest, shedding, and absence before a new anagen phase

Goldbeter, Albert

94

Fast Synthetic Vision, Memory, and Learning Models for Virtual Humans James J. Kuffner, Jr JeanClaude Latombe  

E-Print Network [OSTI]

Fast Synthetic Vision, Memory, and Learning Models for Virtual Humans James J. Kuffner, Jr Jean, and learning for au­ tonomous animated characters in real­time virtual environ­ ments. The model is efficient of quickly synthesizing from navigation goals the collision­free mo­ tions for animated human figures

Pratt, Vaughan

95

Effects of phenylpropanolamine (PPA) on in vitro human erythrocyte membranes and molecular models  

SciTech Connect (OSTI)

Research highlights: {yields} PPA is a common ingredient in cough-cold medication and appetite suppressants. {yields} Reports on its effects on human erythrocytes are very scarce. {yields} We found that PPA induced in vitro morphological changes to human erythrocytes. {yields} PPA interacted with isolated unsealed human erythrocyte membranes. {yields} PPA interacted with class of lipid present in the erythrocyte membrane outer monolayer. -- Abstract: Norephedrine, also called phenylpropanolamine (PPA), is a synthetic form of the ephedrine alkaloid. After reports of the occurrence of intracranial hemorrhage and other adverse effects, including several deaths, PPA is no longer sold in USA and Canada. Despite the extensive information about PPA toxicity, reports on its effects on cell membranes are scarce. With the aim to better understand the molecular mechanisms of the interaction of PPA with cell membranes, ranges of concentrations were incubated with intact human erythrocytes, isolated unsealed human erythrocyte membranes (IUM), and molecular models of cell membranes. The latter consisted in bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), phospholipid classes present in the outer and inner monolayers of most plasmatic cell membranes, respectively. The capacity of PPA to perturb the bilayer structures of DMPC and DMPE was assessed by X-ray diffraction, DMPC large unilamellar vesicles (LUV) and IUM were studied by fluorescence spectroscopy, and intact human erythrocytes were observed by scanning electron microscopy (SEM). This study presents evidence that PPA affects human red cell membranes as follows: (a) in SEM studies on human erythrocytes it was observed that 0.5 mM PPA induced shape changes; (b) in IUM PPA induced a sharp decrease in the fluorescence anisotropy in the lipid bilayer acyl chains in a concentration range lower than 100 {mu}M; (c) X-ray diffraction studies showed that PPA in the 0.1-0.5 mM range induced increasing structural perturbation to DMPC, but no effects on DMPE multibilayers were detected.

Suwalsky, Mario, E-mail: msuwalsk@udec.cl [Faculty of Chemical Sciences, University of Concepcion, Concepcion (Chile)] [Faculty of Chemical Sciences, University of Concepcion, Concepcion (Chile); Zambrano, Pablo; Mennickent, Sigrid [Faculty of Pharmacy, University of Concepcion, Concepcion (Chile)] [Faculty of Pharmacy, University of Concepcion, Concepcion (Chile); Villena, Fernando [Faculty of Biological Sciences, University of Concepcion, Concepcion (Chile)] [Faculty of Biological Sciences, University of Concepcion, Concepcion (Chile); Sotomayor, Carlos P.; Aguilar, Luis F. [Instituto de Quimica, Pontificia Universidad Catolica de Valparaiso, Valparaiso (Chile)] [Instituto de Quimica, Pontificia Universidad Catolica de Valparaiso, Valparaiso (Chile); Bolognin, Silvia [CNR-Institute for Biomedical Technologies, University of Padova, Padova (Italy)] [CNR-Institute for Biomedical Technologies, University of Padova, Padova (Italy)

2011-03-18T23:59:59.000Z

96

Toward hydro-social modeling: Merging human variables and the social sciences with climate-glacier runoff models (Santa River, Peru)  

E-Print Network [OSTI]

Toward hydro-social modeling: Merging human variables and the social sciences with climate mountain range, this paper provides a holistic hydro-social framework that identifies five major human of watershed dynamics. This hydro-social framework has wide- spread implications for hydrological modeling

McKenzie, Jeffrey M.

97

The Use Of Computational Human Performance Modeling As Task Analysis Tool  

SciTech Connect (OSTI)

During a review of the Advanced Test Reactor safety basis at the Idaho National Laboratory, human factors engineers identified ergonomic and human reliability risks involving the inadvertent exposure of a fuel element to the air during manual fuel movement and inspection in the canal. There were clear indications that these risks increased the probability of human error and possible severe physical outcomes to the operator. In response to this concern, a detailed study was conducted to determine the probability of the inadvertent exposure of a fuel element. Due to practical and safety constraints, the task network analysis technique was employed to study the work procedures at the canal. Discrete-event simulation software was used to model the entire procedure as well as the salient physical attributes of the task environment, such as distances walked, the effect of dropped tools, the effect of hazardous body postures, and physical exertion due to strenuous tool handling. The model also allowed analysis of the effect of cognitive processes such as visual perception demands, auditory information and verbal communication. The model made it possible to obtain reliable predictions of operator performance and workload estimates. It was also found that operator workload as well as the probability of human error in the fuel inspection and transfer task were influenced by the concurrent nature of certain phases of the task and the associated demand on cognitive and physical resources. More importantly, it was possible to determine with reasonable accuracy the stages as well as physical locations in the fuel handling task where operators would be most at risk of losing their balance and falling into the canal. The model also provided sufficient information for a human reliability analysis that indicated that the postulated fuel exposure accident was less than credible.

Jacuqes Hugo; David Gertman

2012-07-01T23:59:59.000Z

98

"Skin Cancer-What to Look For" Rochester Recreation  

E-Print Network [OSTI]

"Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

Goldman, Steven A.

99

A Human Life-Stage Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Chlorpyrifos: Development and Validation  

SciTech Connect (OSTI)

Sensitivity to chemicals in animals and humans are known to vary with age. Age-related changes in sensitivity to chlorpyrifos have been reported in animal models. A life-stage physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model was developed to computationally predict disposition of CPF and its metabolites, chlorpyrifos-oxon (the ultimate toxicant) and 3,5,6-trichloro-2-pyridinol (TCPy), as well as B-esterase inhibition by chlorpyrifos-oxon in humans. In this model, age-dependent body weight was calculated from a generalized Gompertz function, and compartments (liver, brain, fat, blood, diaphragm, rapid, and slow) were scaled based on body weight from polynomial functions on a fractional body weight basis. Blood flows among compartments were calculated as a constant flow per compartment volume. The life-stage PBPK/PD model was calibrated and tested against controlled adult human exposure studies. Model simulations suggest age-dependent pharmacokinetics and response may exist. At oral doses ? 0.55 mg/kg of chlorpyrifos (significantly higher than environmental exposure levels), 6 mo old children are predicted to have higher levels of chlorpyrifos-oxon in blood and higher levels of red blood cell cholinesterase inhibition compared to adults from equivalent oral doses of chlorpyrifos. At lower doses that are more relevant to environmental exposures, the model predicts that adults will have slightly higher levels of chlorpyrifos-oxon in blood and greater cholinesterase inhibition. This model provides a computational framework for age-comparative simulations that can be utilized to predict CPF disposition and biological response over various postnatal life-stages.

Smith, Jordan N.; Hinderliter, Paul M.; Timchalk, Charles; Bartels, M. J.; Poet, Torka S.

2014-08-01T23:59:59.000Z

100

A new muscle fatigue and recovery model and its ergonomics application in human simulation  

E-Print Network [OSTI]

Although automatic techniques have been employed in manufacturing industries to increase productivity and efficiency, there are still lots of manual handling jobs, especially for assembly and maintenance jobs. In these jobs, musculoskeletal disorders (MSDs) are one of the major health problems due to overload and cumulative physical fatigue. With combination of conventional posture analysis techniques, digital human modelling and simulation (DHM) techniques have been developed and commercialized to evaluate the potential physical exposures. However, those ergonomics analysis tools are mainly based on posture analysis techniques, and until now there is still no fatigue index available in the commercial software to evaluate the physical fatigue easily and quickly. In this paper, a new muscle fatigue and recovery model is proposed and extended to evaluate joint fatigue level in manual handling jobs. A special application case is described and analyzed by digital human simulation technique.

Ma, Liang; Bennis, Fouad; Zhang, Wei; Guillaume, François; 10.1080/17452759.2010.504056

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

A new muscle fatigue and recovery model and its ergonomics application in human simulation  

E-Print Network [OSTI]

Although automatic techniques have been employed in manufacturing industries to increase productivity and efficiency, there are still lots of manual handling jobs, especially for assembly and maintenance jobs. In these jobs, musculoskeletal disorders (MSDs) are one of the major health problems due to overload and cumulative physical fatigue. With combination of conventional posture analysis techniques, digital human modelling and simulation (DHM) techniques have been developed and commercialized to evaluate the potential physical exposures. However, those ergonomics analysis tools are mainly based on posture analysis techniques, and until now there is still no fatigue index available in the commercial software to evaluate the physical fatigue easily and quickly. In this paper, a new muscle fatigue and recovery model is proposed and extended to evaluate joint fatigue level in manual handling jobs. A special application case is described and analyzed by digital human simulation technique.

Ma, Liang; Bennis, Fouad; Zhang, Wei; Guillaume, François

2009-01-01T23:59:59.000Z

102

Effect of dietary polyunsaturated fatty acids and related nutrients on sebum lipids, and skin and hair coat condition in canines  

E-Print Network [OSTI]

to 7 Table 1.1 Composition (wt%) of skin surface lipids in selected mammals. Although skin surface lipids have been analyzed in over 70 mammalian species, only data from humans and some domestic animals are presented here. Note the marked...

Kirby, Naomi Anne

2005-02-17T23:59:59.000Z

103

Lasers in Surgery and Medicine 28:113120 (2001) Inuence of Nozzle-to-Skin Distance in Cryogen Spray  

E-Print Network [OSTI]

of dis- tance from the nozzle tip. Results: Size of spray cones and sprayed areas vary with distanceLasers in Surgery and Medicine 28:113±120 (2001) In¯uence of Nozzle-to-Skin Distance in Cryogen, the optimal atomizing nozzle design and operating conditions for cooling human skin remain to be determined

Aguilar, Guillermo

2001-01-01T23:59:59.000Z

104

A mathematical model of probability of conception in humans, and an analysis of the rhythm technique of birth control  

E-Print Network [OSTI]

) and iii) were combined to yield a model of, probability of conception per cycle given the following user related information: a) exact rhythm method formulation, if any, used; b) pattern and frequency of intercourse used; and c) the age group (or age..., and (c) the overall menstrual cycle lengths in human females. The development of a mathematical model describing the effective human sperm and ovum longevity was the second objective. The third objective was the development of a model to estimate...

Nordheim, Alan Walter

1979-01-01T23:59:59.000Z

105

Turbine vane with high temperature capable skins  

DOE Patents [OSTI]

A turbine vane assembly includes an airfoil extending between an inner shroud and an outer shroud. The airfoil can include a substructure having an outer peripheral surface. At least a portion of the outer peripheral surface is covered by an external skin. The external skin can be made of a high temperature capable material, such as oxide dispersion strengthened alloys, intermetallic alloys, ceramic matrix composites or refractory alloys. The external skin can be formed, and the airfoil can be subsequently bi-cast around or onto the skin. The skin and the substructure can be attached by a plurality of attachment members extending between the skin and the substructure. The skin can be spaced from the outer peripheral surface of the substructure such that a cavity is formed therebetween. Coolant can be supplied to the cavity. Skins can also be applied to the gas path faces of the inner and outer shrouds.

Morrison, Jay A. (Oviedo, FL)

2012-07-10T23:59:59.000Z

106

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model  

SciTech Connect (OSTI)

Research highlights: {yields} Establish a human immune-mediated type 1 diabetic model in NOD-scid IL2r{gamma}{sup null} mice. {yields} Using the irradiated diabetic NOD mouse spleen mononuclear cells as trigger. {yields} The islet {beta} cells were selectively destroyed by infiltrated human T cells. {yields} The model can facilitate translational research to find a cure for type 1 diabetes. -- Abstract: Type 1 diabetes (T1D) is caused by a T cell-mediated autoimmune response that leads to the loss of insulin-producing {beta} cells. The optimal preclinical testing of promising therapies would be aided by a humanized immune-mediated T1D model. We develop this model in NOD-scid IL2r{gamma}{sup null} mice. The selective destruction of pancreatic islet {beta} cells was mediated by human T lymphocytes after an initial trigger was supplied by the injection of irradiated spleen mononuclear cells (SMC) from diabetic nonobese diabetic (NOD) mice. This resulted in severe insulitis, a marked loss of total {beta}-cell mass, and other related phenotypes of T1D. The migration of human T cells to pancreatic islets was controlled by the {beta} cell-produced highly conserved chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C-X-C chemokine receptor (CXCR) 4, as demonstrated by in vivo blocking experiments using antibody to CXCR4. The specificity of humanized T cell-mediated immune responses against islet {beta} cells was generated by the local inflammatory microenvironment in pancreatic islets including human CD4{sup +} T cell infiltration and clonal expansion, and the mouse islet {beta}-cell-derived CD1d-mediated human iNKT activation. The selective destruction of mouse islet {beta} cells by a human T cell-mediated immune response in this humanized T1D model can mimic those observed in T1D patients. This model can provide a valuable tool for translational research into T1D.

Zhao, Yong, E-mail: yongzhao@uic.edu [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Guo, Chengshan; Hwang, David; Lin, Brian; Dingeldein, Michael; Mihailescu, Dan; Sam, Susan; Sidhwani, Seema [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Zhang, Yongkang [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Jain, Sumit [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Skidgel, Randal A. [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Prabhakar, Bellur S. [Department of Immunology and Microbiology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Immunology and Microbiology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Mazzone, Theodore [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Holterman, Mark J. [Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612 (United States)

2010-09-03T23:59:59.000Z

107

A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury  

SciTech Connect (OSTI)

Background: Human liver has an unusual sensitivity to radiation that limits its use in cancer therapy or in preconditioning for hepatocyte transplantation. Because the characteristic veno-occlusive lesions of radiation-induced liver disease do not occur in rodents, there has been no experimental model to investigate the limits of safe radiation therapy or explore the pathogenesis of hepatic veno-occlusive disease. Methods and Materials: We performed a dose-escalation study in a primate, the cynomolgus monkey, using hypofractionated stereotactic body radiotherapy in 13 animals. Results: At doses ?40 Gy, animals developed a systemic syndrome resembling human radiation-induced liver disease, consisting of decreased albumin, elevated alkaline phosphatase, loss of appetite, ascites, and normal bilirubin. Higher radiation doses were lethal, causing severe disease that required euthanasia approximately 10 weeks after radiation. Even at lower doses in which radiation-induced liver disease was mild or nonexistent, latent and significant injury to hepatocytes was demonstrated by asialoglycoprotein-mediated functional imaging. These monkeys developed hepatic failure with encephalopathy when they received parenteral nutrition containing high concentrations of glucose. Histologically, livers showed central obstruction via an unusual intimal swelling that progressed to central fibrosis. Conclusions: The cynomolgus monkey, as the first animal model of human veno-occlusive radiation-induced liver disease, provides a resource for characterizing the early changes and pathogenesis of venocclusion, for establishing nonlethal therapeutic dosages, and for examining experimental therapies to minimize radiation injury.

Yannam, Govardhana Rao [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Han, Bing [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi (China); Setoyama, Kentaro [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamamoto, Toshiyuki [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Ito, Ryotaro; Brooks, Jenna M. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Guzman-Lepe, Jorge [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Galambos, Csaba [Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Fong, Jason V. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Deutsch, Melvin; Quader, Mubina A. [Department of Radiation Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamanouchi, Kosho [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York (United States); Kabarriti, Rafi; Mehta, Keyur [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Soto-Gutierrez, Alejandro [Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); and others

2014-02-01T23:59:59.000Z

108

Modeling and Quantification of Team Performance in Human Reliability Analysis for Probabilistic Risk Assessment  

SciTech Connect (OSTI)

Probabilistic Risk Assessment (PRA) and Human Reliability Assessment (HRA) are important technical contributors to the United States (U.S.) Nuclear Regulatory Commission’s (NRC) risk-informed and performance based approach to regulating U.S. commercial nuclear activities. Furthermore, all currently operating commercial NPPs in the U.S. are required by federal regulation to be staffed with crews of operators. Yet, aspects of team performance are underspecified in most HRA methods that are widely used in the nuclear industry. There are a variety of "emergent" team cognition and teamwork errors (e.g., communication errors) that are 1) distinct from individual human errors, and 2) important to understand from a PRA perspective. The lack of robust models or quantification of team performance is an issue that affects the accuracy and validity of HRA methods and models, leading to significant uncertainty in estimating HEPs. This paper describes research that has the objective to model and quantify team dynamics and teamwork within NPP control room crews for risk informed applications, thereby improving the technical basis of HRA, which improves the risk-informed approach the NRC uses to regulate the U.S. commercial nuclear industry.

Jeffrey C. JOe; Ronald L. Boring

2014-06-01T23:59:59.000Z

109

Human Factors Engineering Program Review Model (NUREG-0711)Revision 3: Update Methodology and Key Revisions  

SciTech Connect (OSTI)

The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. NUREG-0711 is the first document to be addressed. We present the methodology used to update NUREG-0711 and summarize the main changes made. Finally, we discuss the current status of the update program and the future plans.

OHara J. M.; Higgins, J.; Fleger, S.

2012-07-22T23:59:59.000Z

110

Development and Construction of Bioclimatic Double Skin Active Facade for Hot and Humid Climate of UAE  

E-Print Network [OSTI]

tracking venetian blinds, LED (light emitting diodes) lighting and Building Management system. 1.01 Modeling And Simulation Of Double Skin Active Facade The modeling and simulation of the Double Skin Fa?ade Cavity is a complicated task, since... sweating/condensation on the water coil. 3.06 LED (Light Emitting Diode) Lighting The building is illuminated using extremely energy efficient LED?s which last 5 times as long as fluorescents and 50 times longer than typical incandescent. So...

Karbor, R. G.; Mohamed, I.

2010-01-01T23:59:59.000Z

111

Stationary turbine component with laminated skin  

DOE Patents [OSTI]

A stationary turbine engine component, such as a turbine vane, includes a internal spar and an external skin. The internal spar is made of a plurality of spar laminates, and the external skin is made of a plurality of skin laminates. The plurality of skin laminates interlockingly engage the plurality of spar laminates such that the external skin is located and held in place. This arrangement allows alternative high temperature materials to be used on turbine engine components in areas where their properties are needed without having to make the entire component out of such material. Thus, the manufacturing difficulties associated with making an entire component of such a material and the attendant high costs are avoided. The skin laminates can be made of advanced generation single crystal superalloys, intermetallics and refractory alloys.

James, Allister W. (Orlando, FL)

2012-08-14T23:59:59.000Z

112

Bio-inspired nanocomposite assemblies as smart skin components.  

SciTech Connect (OSTI)

There is national interest in the development of sophisticated materials that can automatically detect and respond to chemical and biological threats without the need for human intervention. In living systems, cell membranes perform such functions on a routine basis, detecting threats, communicating with the cell, and triggering automatic responses such as the opening and closing of ion channels. The purpose of this project was to learn how to replicate simple threat detection and response functions within artificial membrane systems. The original goals toward developing 'smart skin' assemblies included: (1) synthesizing functionalized nanoparticles to produce electrochemically responsive systems within a lipid bilayer host matrices, (2) calculating the energetics of nanoparticle-lipid interactions and pore formation, and (3) determining the mechanism of insertion of nanoparticles in lipid bilayers via imaging and electrochemistry. There are a few reports of the use of programmable materials to open and close pores in rigid hosts such as mesoporous materials using either heat or light activation. However, none of these materials can regulate themselves in response to the detection of threats. The strategies we investigated in this project involve learning how to use programmable nanomaterials to automatically eliminate open channels within a lipid bilayer host when 'threats' are detected. We generated and characterized functionalized nanoparticles that can be used to create synthetic pores through the membrane and investigated methods of eliminating the pores either through electrochemistry, change in pH, etc. We also focused on characterizing the behavior of functionalized gold NPs in different lipid membranes and lipid vesicles and coupled these results to modeling efforts designed to gain an understanding of the interaction of nanoparticles within lipid assemblies.

Montano, Gabriel A.; Xiao, Xiaoyin; Achyuthan, Komandoor E.; Allen, Amy; Brozik, Susan Marie; Edwards, Thayne L.; Frischknecht, Amalie Lucile; Wheeler, David Roger

2011-09-01T23:59:59.000Z

113

Human performance modeling for system of systems analytics: combat performance-shaping factors.  

SciTech Connect (OSTI)

The US military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives. To support this goal, Sandia National Laboratories (SNL) has undertaken a program of HPM as an integral augmentation to its system-of-system (SoS) analytics capabilities. The previous effort, reported in SAND2005-6569, evaluated the effects of soldier cognitive fatigue on SoS performance. The current effort began with a very broad survey of any performance-shaping factors (PSFs) that also might affect soldiers performance in combat situations. The work included consideration of three different approaches to cognition modeling and how appropriate they would be for application to SoS analytics. This bulk of this report categorizes 47 PSFs into three groups (internal, external, and task-related) and provides brief descriptions of how each affects combat performance, according to the literature. The PSFs were then assembled into a matrix with 22 representative military tasks and assigned one of four levels of estimated negative impact on task performance, based on the literature. Blank versions of the matrix were then sent to two ex-military subject-matter experts to be filled out based on their personal experiences. Data analysis was performed to identify the consensus most influential PSFs. Results indicate that combat-related injury, cognitive fatigue, inadequate training, physical fatigue, thirst, stress, poor perceptual processing, and presence of chemical agents are among the PSFs with the most negative impact on combat performance.

Lawton, Craig R.; Miller, Dwight Peter

2006-01-01T23:59:59.000Z

114

Computational formulation, modeling and evaluation of human-robot team training techniques  

E-Print Network [OSTI]

This thesis is focused on designing mechanisms for programming robots and training people to perform human-robot collaborative tasks, drawing upon insights from practices widely used in human teams. First, we design and ...

Nikolaidis, Stefanos Z

2014-01-01T23:59:59.000Z

115

autologous serum skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

116

alter skin microcirculation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

117

ameliorate genetic skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

118

A Multi-Methods Approach to HRA and Human Performance Modeling: A Field Assessment  

SciTech Connect (OSTI)

The Advanced Test Reactor (ATR) is a research reactor at the Idaho National Laboratory is primarily designed and used to test materials to be used in other, larger-scale and prototype reactors. The reactor offers various specialized systems and allows certain experiments to be run at their own temperature and pressure. The ATR Canal temporarily stores completed experiments and used fuel. It also has facilities to conduct underwater operations such as experiment examination or removal. In reviewing the ATR safety basis, a number of concerns were identified involving the ATR canal. A brief study identified ergonomic issues involving the manual handling of fuel elements in the canal that may increase the probability of human error and possible unwanted acute physical outcomes to the operator. In response to this concern, that refined the previous HRA scoping analysis by determining the probability of the inadvertent exposure of a fuel element to the air during fuel movement and inspection was conducted. The HRA analysis employed the SPAR-H method and was supplemented by information gained from a detailed analysis of the fuel inspection and transfer tasks. This latter analysis included ergonomics, work cycles, task duration, and workload imposed by tool and workplace characteristics, personal protective clothing, and operational practices that have the potential to increase physical and mental workload. Part of this analysis consisted of NASA-TLX analyses, combined with operational sequence analysis, computational human performance analysis (CHPA), and 3D graphical modeling to determine task failures and precursors to such failures that have safety implications. Experience in applying multiple analysis techniques in support of HRA methods is discussed.

Jacques Hugo; David I Gertman

2012-06-01T23:59:59.000Z

119

Beyond the skin bag: on the moral responsibility of extended agencies  

E-Print Network [OSTI]

and extended agency The view of the subject as only the human individual is known as methodological individualism. This theory holds that subjects are human beings entirely contained in their “skin bags” (Clark 2003), that maintain their identity... to ride a bicycle. “Be careful not to run into people or things, don’t crash your bike or hurt yourself, and especially don’t ride into the street without looking.” Her responsibility with the bicycle is, however, considerably less momentous than...

Hanson, F. Allan

2009-03-01T23:59:59.000Z

120

Eliciting a human understandable model of ice adhesion strength for rotor blade leading edge materials from uncertain experimental data  

E-Print Network [OSTI]

Eliciting a human understandable model of ice adhesion strength for rotor blade leading edge: Genetic Fuzzy Systems Fuzzy rule-based classifiers Vague data Isotropic materials Ice-phobic materials Shear adhesion strength a b s t r a c t The published ice adhesion performance data of novel ``ice

Granada, Universidad de

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Skin thickness effects on in vivo LXRF  

SciTech Connect (OSTI)

The analysis of lead concentration in bone utilizing LXRF can be adversely effected by overlying issue. A quantitative measure of the attenuation of the 10.5 keV Pb L a x-ray signal by skin and skin equivalent plastic has been conducted. Concentration ranges in plaster of Paris and goat bone from 7 to 90 ppm with attenuators of Lucite{reg_sign} and pig skin were examined. It is concluded that no quantitative or semi quantitative analysis can be achieved if overlying sue thickness exceeds 3 mm for Ph concentrations of less than 30 porn Ph in bone.

Preiss, I.L.; Washington, W. II [Rensselaer Polytechnic Inst., Troy, NY (United States)

1995-12-31T23:59:59.000Z

122

Skin friction for steel piles in sand  

E-Print Network [OSTI]

SkiN FRICTION FOR STEZL PIIZS IN SAND A Theeia by I. H. Sulaiman Submittei io the graduate College of t, he Texan AAB Univen-ity in Ixantial fulfil. ment of bhe zequiremenbu for the degree of NASTZR 0F SCISNCZ May 196'7 bsrjor Subject...: Civil Engineering SKIN FRICTION FOR STEEL PILES IN SAND A Thesis by I. H. Sulaiman Approved as to style and content by: Chairman of C mmittee Head of Department Memb Member 111 Skin Friction For Steel Piles in Sand (May 1967) Ibr shim Hikmat...

Sulaiman, Ibrahim Hikmat

2012-06-07T23:59:59.000Z

123

Liu, Z., H.C. Frey, Y. Cao, and B. Deshpande, "Modeling of In-vehicle PM2.5 Exposure Using the Stochastic Human Exposure and Dose Simulation Model," Paper 2009-A-238-AWMA, Proceedings, 102nd  

E-Print Network [OSTI]

the Stochastic Human Exposure and Dose Simulation Model," Paper 2009-A-238-AWMA, Proceedings, 102nd Annual of In-vehicle PM2.5 Exposure Using the Stochastic Human Exposure and Dose Simulation Model Paper: 2009-A in the current version of Stochastic Exposure and Dose Simulation model for Particulate Matter (SHEDS-PM) for in

Frey, H. Christopher

124

Phosphoproteomics profiling of human skin fibroblast cells reveals pathways  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - September 2006 TheSteven AshbyDepartmentPersonnelAdams5EMSLBluetheoreticaland

125

A Computational Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence across the Lifespan in the Human Population  

E-Print Network [OSTI]

Glioma is the most common form of primary brain tumor. Demographically, the risk of occurrence increases until old age. Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan. Previous mathematical models explaining glioma incidence are framed in a rather abstract way, and do not directly relate to empirical findings. To decrease this gap between theory and experimental observations, we incorporate recent data on cellular and molecular factors underlying gliomagenesis. Since evidence implicates the adult neural stem cell as the likely cell-of-origin of glioma, we have incorporated empirically-determined estimates of neural stem cell number, cell division rate, mutation rate and oncogenic potential into our model. We demonstrate that our model yields results which match actual demographic data in the human population. In particular, this model accounts for the observed peak incidence of glioma at approximately 80 years of age, without the need to assert...

Bauer, Roman; Stoll, Elizabeth

2015-01-01T23:59:59.000Z

126

Simulation of human motion data using short-horizon model-predictive control  

E-Print Network [OSTI]

Many data-driven animation techniques are capable of producing high quality motions of human characters. Few techniques, however, are capable of generating motions that are consistent with physically simulated environments. ...

Silva, Marco Jorge Tome da

2008-01-01T23:59:59.000Z

127

A generalized self consistent model for effective elastic moduli of human dentine  

E-Print Network [OSTI]

Consistent Model for cell model of fiber-reinforced composites is extended to the case of hollow cylinder model and the corresponding cell model is chosen to consist of a circular hollow cylinder filled from other models such as nano-indentation method. Ã? 2006 Elsevier Ltd. All rights reserved. Keywords

Qin, Qinghua

128

A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans  

SciTech Connect (OSTI)

The pharmacokinetics of nicotine, the pharmacologically active alkaloid in tobacco responsible for addiction, are well characterized in humans. We developed a physiologically based pharmacokinetic/pharmacodynamic model of nicotine pharmacokinetics, brain dosimetry and brain nicotinic acetylcholine receptor (nAChRs) occupancy. A Bayesian framework was applied to optimize model parameters against multiple human data sets. The resulting model was consistent with both calibration and test data sets, but in general underestimated variability. A pharmacodynamic model relating nicotine levels to increases in heart rate as a proxy for the pharmacological effects of nicotine accurately described the nicotine related changes in heart rate and the development and decay of tolerance to nicotine. The PBPK model was utilized to quantitatively capture the combined impact of variation in physiological and metabolic parameters, nicotine availability and smoking compensation on the change in number of cigarettes smoked and toxicant exposure in a population of 10,000 people presented with a reduced toxicant (50%), reduced nicotine (50%) cigarette Across the population, toxicant exposure is reduced in some but not all smokers. Reductions are not in proportion to reductions in toxicant yields, largely due to partial compensation in response to reduced nicotine yields. This framework can be used as a key element of a dosimetry-driven risk assessment strategy for cigarette smoke constituents.

Teeguarden, Justin G.; Housand, Conrad; Smith, Jordan N.; Hinderliter, Paul M.; Gunawan, Rudy; Timchalk, Charles

2013-02-01T23:59:59.000Z

129

Negative skin friction at Keehi interchange  

E-Print Network [OSTI]

is assumed to be the sum of the structural load, gt, a drag force, F'n, due to the fill within the pile group and a drag force F'n due to the negative skin friction of the soft layer. F = ()t + F'n + F"n (2. 1) where F'n is the weight of fill carried... of this method for an actual case. 2. 2. 3 Brome Brome (1969) describes the state of the practice in Sweden for the calculation of drag forces on piles due to negative skin friction. In Sweden most piles are driven to rock. The compression of the pile...

Porwoll, Hubert

2012-06-07T23:59:59.000Z

130

Human-machine interactions  

SciTech Connect (OSTI)

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

131

Applying Human-performance Models to Designing and Evaluating Nuclear Power Plants: Review Guidance and Technical Basis  

SciTech Connect (OSTI)

Human performance models (HPMs) are simulations of human behavior with which we can predict human performance. Designers use them to support their human factors engineering (HFE) programs for a wide range of complex systems, including commercial nuclear power plants. Applicants to U.S. Nuclear Regulatory Commission (NRC) can use HPMs for design certifications, operating licenses, and license amendments. In the context of nuclear-plant safety, it is important to assure that HPMs are verified and validated, and their usage is consistent with their intended purpose. Using HPMs improperly may generate misleading or incorrect information, entailing safety concerns. The objective of this research was to develop guidance to support the NRC staff's reviews of an applicant's use of HPMs in an HFE program. The guidance is divided into three topical areas: (1) HPM Verification, (2) HPM Validation, and (3) User Interface Verification. Following this guidance will help ensure the benefits of HPMs are achieved in a technically sound, defensible manner. During the course of developing this guidance, I identified several issues that could not be addressed; they also are discussed.

O'Hara, J.M.

2009-11-30T23:59:59.000Z

132

Influence of neutron-skin thickness on $?^{-}/?^{+}$ ratio in Pb+Pb collisions  

E-Print Network [OSTI]

Within an isospin- and momentum-dependent transport model IBUU11 using as an input nucleon density profiles from Hartree-Fock calculations based on a modified Skyrme-like (MSL) model, we study the influence of the uncertainty of the neutron skin thickness on the $\\pi^{-}/\\pi^{+}$ ratio in both central and peripheral Pb+Pb collisions at beam energies of 400 MeV/nucleon and 1000 MeV/nucleon. Within the current experimental uncertainty range of neutron skin in $^{208}$Pb, while the neutron skin effect on the \\rpi ratio is negligible in central reactions at both energies, it increases gradually with increasing impact parameter and becomes comparable with or even larger than the symmetry energy effect in peripheral collisions especially at 400 MeV/nucleon. Moreover, we found that while the \\rpi ratio is larger with a softer \\esym in central collisions, above certain impact parameters depending on the size of the neutron skin, a stiffer \\esym can lead to a larger \\rpi ratio as most of the pions are produced at densities below the saturation density in these peripheral reactions. Thus, a clear impact parameter selection is important to extract reliable information about the \\esym at suprasaturation densities (size of neutron skin) from the $\\pi^-/\\pi^+$ ratio in central (peripheral) heavy-ion collisions.

Gao-Feng Wei; Bao-An Li; Jun Xu; Lie-Wen Chen

2015-01-21T23:59:59.000Z

133

Simplified methods of modeling multilayer reservoirs  

E-Print Network [OSTI]

during the boundary-dominated flow period. We also examined modeling the pressure response during pseudosteady state flow in a multilayer system with skin factors in individual layers using a single layer solution which includes an equivalent skin factor...

Ryou, Sangsoo

1993-01-01T23:59:59.000Z

134

A new cost-distance model for human accessibility and an evaluation of accessibility bias in permanent vegetation plots in Great Smoky  

E-Print Network [OSTI]

A new cost-distance model for human accessibility and an evaluation of accessibility bias-mail toddjobe@unc.edu Abstract Question: Can a new cost-distance model help us to evaluate the potential crossings, and vegeta- tion density were incorporated into a least-cost model of energetic expenditure

Peet, Robert K.

135

Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK model.  

SciTech Connect (OSTI)

Hydroquinone (HQ) is an important industrial chemical that also occurs naturally in foods and in the leaves and bark of a number of plant species. Exposure of laboratory animals to HQ may result in a species-, sex-, and strain-specific nephrotoxicity. The sensitivity of male F344 vs. female F344 and Sprague-Dawley rats or B6C3F1 mice appears to be related to differences in the rates of formation and further metabolism of key nephrotoxic metabolites. Metabolic rate constants for the conversion of HQ through several metabolic steps to the mono-glutathione conjugate and subsequent detoxification via mercapturic acid were measured in suspension cultures of hepatocytes isolated from male F344 rats and humans. An in vitro mathematic kinetic model was used to analyze each metabolic step by simultaneously fitting the disappearance of each substrate and the appearance of subsequent metabolites. An iterative, nested approach was used whereby downstream metabolites were considered first and the model was constrained by the requirement that rate constants determined during analysis of individual metabolic steps must also satisfy the complete, integrated metabolism scheme, including competitive pathways. The results from this study indicated that the overall capacity for metabolism of HQ and its mono-glutathione conjugate is greater in hepatocytes from humans than those isolated from rats, suggesting a greater capacity for detoxification of the glutathione conjugates. Metabolic rate constants were applied to an existing physiologically based pharmacokinetic model and the model was used to predict total glutathione metabolites produced in the liver. The results showed that body burdens of these metabolites will be much higher in rats than humans.

Poet, Torka S.; Wu, Hong; English, J C.; Corley, Rick A.

2004-11-15T23:59:59.000Z

136

Population Physiologically-Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB 153 with Consideration of Worldwide Human Biomonitoring Results  

E-Print Network [OSTI]

Disease Control and Prevention (CDC), which released its Third National Report on Human Exposure to Environmental Chemicals

Redding, Laurel E.

2010-01-01T23:59:59.000Z

137

Active skin for turbulent drag reduction  

E-Print Network [OSTI]

pursued is "micro" in the sense that only micro-scale wave amplitudes (order of 30[]m) and energy inputs are sufficient to produce significant benefits. Two actuation principles are proposed and analyzed and different skin designs based on these two...

Mani, Raghavendran

2002-01-01T23:59:59.000Z

138

Preventive Skin Care Fact or Fiction?  

E-Print Network [OSTI]

and colors Many are birthmarks http://www.skinsight.com/images/dx/webInfant/congenitalMelanocyticNevus_33234 by skin biopsy to make sure not cancer http://www.skinsight.com/images/dx/webInfant/congenital://www.skincancer.org/understanding-uva-and-uvb.html #12;Practice GOOD habits! · Reapply sunscreen if: ­ Sweating ­ Swimming in water ­ Doing any activity

Goldman, Steven A.

139

Skin Bleaching in Jamaica: A Colonial Legacy  

E-Print Network [OSTI]

of Eurocentric values and a denigration of Afrocentric values in many facets of life, specifically in the promotion of light skin as an indicator of beauty and social status. The purpose of this study was to examine the psychological and socio-cultural factors...

Robinson, Petra Alaine

2012-07-16T23:59:59.000Z

140

Task-Model Based Human Robot Cooperation Using Vision 3 Hiroshi Kimura and Tomoyuki Horiuchi  

E-Print Network [OSTI]

For the purpose of the child care and nursing care, we are developing the robot which can assist the hu- man 182 Katsushi Ikeuchi Institute of Industrial Science, Univ. of Tokyo 7-22-1 Roppongi, Minato-ku, Tokyo an experiment in which the human and the robotic hand assembled toy parts in cooperation. 1 Introduction

Kimura, Hiroshi

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Self-cleaning skin-like prosthetic polymer surfaces  

DOE Patents [OSTI]

An external covering and method of making an external covering for hiding the internal endoskeleton of a mechanical (e.g., prosthetic) device that exhibits skin-like qualities is provided. The external covering generally comprises an internal bulk layer in contact with the endoskeleton of the prosthetic device and an external skin layer disposed about the internal bulk layer. The external skin layer is comprised of a polymer composite with carbon nanotubes embedded therein. The outer surface of the skin layer has multiple cone-shaped projections that provide the external skin layer with superhydrophobicity. The carbon nanotubes are preferably vertically aligned between the inner surface and outer surface of the external skin layer in order to provide the skin layer with the ability to transmit heat. Superhydrophobic powders may optionally be used as part of the polymer composite or applied as a coating to the surface of the skin layer to enhance superhydrophobicity.

Simpson, John T. (Clinton, TN); Ivanov, Ilia N. (Knoxville, TN); Shibata, Jason (Manhattan Beach, CA)

2012-03-27T23:59:59.000Z

142

Vaccine delivery with microneedle skin patches in nonhuman primates  

E-Print Network [OSTI]

Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

Li, Adrienne V

143

Essays on econometric modeling of subjective perceptions of risks in environment and human health  

E-Print Network [OSTI]

the estimator asymptotically unbiased and efficient. The third essay addresses the problem of modeling perceived mortality risks from arsenic concentrations in drinking water. I estimated a formal model that allows for ambiguity about risk. The empirical...

Nguyen, To Ngoc

2009-05-15T23:59:59.000Z

144

A Benchmark of Computational Models of Saliency to Predict Human Fixations  

E-Print Network [OSTI]

Many computational models of visual attention have been created from a wide variety of different approaches to predict where people look in images. Each model is usually introduced by demonstrating performances on new ...

Judd, Tilke

2012-01-13T23:59:59.000Z

145

Bayesian Modeling Of An Human MMORPG Player Gabriel Synnaevea,c  

E-Print Network [OSTI]

-run factions fighting each other but we modeled a particular domain of multiplayer RPG called players versus

Paris-Sud XI, Université de

146

The Application of User Modeling Techniques to Reason about the Human Contribution to Major Accidents  

E-Print Network [OSTI]

Johnson,C.W. Proceedings of the Seventh International User Modelling Conference (UM'99) pp 13-22 Springer

Johnson, C.W.

147

Modeling Reciprocal Behavior in Human Bilateral Negotiation Ya'akov Gal  

E-Print Network [OSTI]

that interact with people over time. It proposes a model for predicting peo- ple's actions in multiple bilateral significantly improves the predictive power of the model, en- abling it to outperform alternative models that do that computers that interact with people need to represent and to learn the social factors that affect people

Pfeffer, Avi

148

The study of skin permeation mechanism and terpene-skin lipid interaction via nuclear magnetic resonance  

E-Print Network [OSTI]

, lipid extraction, etc. In our case, the interaction between a terpene and a lipid was examinedwith nuclear magnetic resonance (NMR), which aims to provide some insight to enhancement in skin permeation. Palmitic acid (Fig 1), a 16-carbon fatty acid... and oxides were able to producea greater ??. National University of Singapore, 2006 PS77 -The Study of Skin Permeation Mechanism and Terpene-Lipid Interaction via Nuclear Magnetic Resonance Perry Fung Chye Lim a, Xiang Yang Liu b, Meng Huang a, Paul Chi...

Lim, P. F. C.; Liu, Xiang Yang; Huang, Meng; Ho, P. C. L.; Chan, S. Y.

2006-10-27T23:59:59.000Z

149

absorption skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

absorption skin First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Healthy Skin Matters Normal Skin...

150

Water skin anomalies: density, elasticity, hydrophobicity, thermal stability, interface repulsivity, etc  

E-Print Network [OSTI]

Molecular undercoordination induced O:H-O bond relaxation and dual polarization dictates the supersolid behavior of water skins interacting with other substances such as flowing in nanochannels, dancing of water droplets, floating of insects. The BOLS-NEP notion unifies the Wenzel-Cassie-Baxter models and explains controllable transition between hydrophobicity and hydrophilicity.

Chang Q. Sun

2015-02-26T23:59:59.000Z

151

r Human Brain Mapping 30:18771886 (2009) r Dynamic GrangerGeweke Causality Modeling  

E-Print Network [OSTI]

requires a measure of effective connectivity. Previ- ously, structural equation modeling (SEM) has been, Roosevelt Rd., Taipei 106, Taiwan. E-mail: fhlin@ntu.edu.tw or fhlin@nmr.mgh.harvard.edu Received

152

IMEKO TC 18 Symposium Measurement, Analysis and Modelling of Human Functions  

E-Print Network [OSTI]

, a reduced order model is derived; whose inputs are wheel orientations, lateral force and yaw moment. Because of the sinusoidal regression after the frequency analysis. The yaw moment that cannot be measured in our motion measurement system is identified based on computer simulations; whose result is made to be matched

Ito, Satoshi

153

Modeling and Analysis of Affective Influences on Human Experience, Prediction, Decision Making, and Behavior  

E-Print Network [OSTI]

, in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Media Arts and Sciences, on August 6, 2010, in partial fulfillment of the requirements for the degree of Doctor of Philosophy) and task-related confidence. I constructed a new model combining measures to evaluate risk preferences

154

Help:Skins | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Power BasicsGermany: EnergyPower Finance Jump737002°,HavanaElorblocks JumpSkins

155

Skin temperature of the sea as determined by radiometer  

E-Print Network [OSTI]

) Differences Temperature Vapor Press Skin Skin Bkt Skin Bkt -Bkt -Air -Air -Air -Air 120100 120200 120400 120500 1 20600 1 20700 1 20800 1 20900 1 21000 130100 130200 130300 130400 130500 130600 130700 130800 131000 131100 . 6235 . 6732.... FORTRAN program. 57 6. Stepwise analysis of error in radiation temperature of the sea. 65 LIST OF FIGURES Number Page 1. Tracks of Cruise 62 -H-10 along which radiation data were obtained, 2. Comparison of i. nfrared emissivities of water vapor. 14...

Boudreau, Robert Donald

2012-06-07T23:59:59.000Z

156

Turbine blade having a constant thickness airfoil skin  

DOE Patents [OSTI]

A turbine blade is provided for a gas turbine comprising: a support structure comprising a base defining a root of the blade and a framework extending radially outwardly from the base, and an outer skin coupled to the support structure framework. The skin has a generally constant thickness along substantially the entire radial extent thereof. The framework and the skin define an airfoil of the blade.

Marra, John J

2012-10-23T23:59:59.000Z

157

allotransplanted vascularized skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Optimum pulse duration and radiant exposure for vascular laser therapy of dark port-wine skin: a theoretical study Engineering Websites Summary: Optimum pulse duration and...

158

analyzing skin conductance: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

coupling between each tactile sensing chip and a ground Shinoda, Hiroyuki 8 HandWave: Design and Manufacture of a Wearable Wireless Skin Conductance Computer Technologies and...

159

USEtox - The UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in Life Cycle Impact Assessment  

SciTech Connect (OSTI)

Background, Aim and Scope. In 2005 a comprehensive comparison of LCIA toxicity characterisation models was initiated by the UNEP-SETAC Life Cycle Initiative, directly involving the model developers of CalTOX, IMPACT 2002, USES-LCA, BETR, EDIP, WATSON, and EcoSense. In this paper we describe this model-comparison process and its results--in particular the scientific consensus model developed by the model developers. The main objectives of this effort were (i) to identify specific sources of differences between the models' results and structure, (ii) to detect the indispensable model components, and (iii) to build a scientific consensus model from them, representing recommended practice. Methods. A chemical test set of 45 organics covering a wide range of property combinations was selected for this purpose. All models used this set. In three workshops, the model comparison participants identified key fate, exposure and effect issues via comparison of the final characterisation factors and selected intermediate outputs for fate, human exposure and toxic effects for the test set applied to all models. Results. Through this process, we were able to reduce inter-model variation from an initial range of up to 13 orders of magnitude down to no more than 2 orders of magnitude for any substance. This led to the development of USEtox, a scientific consensus model that contains only the most influential model elements. These were, for example, process formulations accounting for intermittent rain, defining a closed or open system environment, or nesting an urban box in a continental box. Discussion. The precision of the new characterisation factors (CFs) is within a factor of 100-1000 for human health and 10-100 for freshwater ecotoxicity of all other models compared to 12 orders of magnitude variation between the CFs of each model respectively. The achieved reduction of inter-model variability by up to 11 orders of magnitude is a significant improvement.Conclusions. USEtox provides a parsimonious and transparent tool for human health and ecosystem CF estimates. Based on a referenced database, it has now been used to calculate CFs for several thousand substances and forms the basis of the recommendations from UNEP-SETAC's Life Cycle Initiative regarding characterization of toxic impacts in Life Cycle Assessment. Recommendations and Perspectives. We provide both recommended and interim (not recommended and to be used with caution) characterisation factors for human health and freshwater ecotoxicity impacts. After a process of consensus building among stakeholders on a broad scale as well as several improvements regarding a wider and easier applicability of the model, USEtox will become available to practitioners for the calculation of further CFs.

Rosenbaum, Ralph K.; Bachmann, Till M.; Swirsky Gold, Lois; Huijbregts, Mark A.J.; Jolliet, Olivier; Juraske, Ronnie; Koehler, Annette; Larsen, Henrik F.; MacLeod, Matthew; Margni, Manuele; McKone, Thomas E.; Payet, Jerome; Schuhmacher, Marta; van de Meent, Dik; Hauschild, Michael Z.

2008-02-03T23:59:59.000Z

160

Quantitative probabilistic modeling of environmental control and life support System resilience for long-duration human spaceflight  

E-Print Network [OSTI]

The future of human space exploration will see crews travel farther and remain in space for longer durations than ever before. For the first time in the history of human spaceflight, the Environmental Control and Life ...

Owens, Andrew Charles

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Carrier-mediated transport of monocarboxylic acids in BeWo cell monolayers as a model of the human trophoblast  

E-Print Network [OSTI]

The monolayer-forming, human choriocarcinoma cell line, BeWo, was used to study the mechanisms of monocarboxylic acid transport across the human trophoblast. Benzoic acid, acetic acid, and lactic acid were used as markers ...

Utoguchi, Naoki; Magnusson, Malin; Audus, Kenneth L.

1999-01-01T23:59:59.000Z

162

Special Issue on Human Computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Nijholt, Anton

163

Social Scaling: From scale-free to stretched exponential models for scalar stress, hierarchy, levels and units in human and technological networks and evolution1  

E-Print Network [OSTI]

at different levels to reduce information and energy load by substituting relationships among leaders. These characteristics of scale-free modeling have been successful in biology, and social scaling may well follow from individuals to groups as a way of renormalizing information load with respect to human attentional

White, Douglas R.

164

allergic skin test: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

allergic skin test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Skin Microbiome in Healthy and...

165

Neutron skin of 208 Pb in consistency with  

E-Print Network [OSTI]

Neutron skin of 208 Pb in consistency with neutron star observations K. Miyazaki E-mail: miyazakiro as varying the neutron radius of 208Pb. The neutron skin thickness Sn is determined in the comparison with the astronomical observations of massive neutron stars (NSs), the standard scenario of NS cooling

166

Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy  

E-Print Network [OSTI]

Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

Smith, Elizabeth Brooks

2009-05-15T23:59:59.000Z

167

Quercitrin protects skin from UVB-induced oxidative damage  

SciTech Connect (OSTI)

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin. - Highlights: • Oxidative stress plays a key role in UV-induced cell and tissue injuries. • Quercitrin decreases ROS generation and restores antioxidants irradiated by UVB. • Quercitrin reduces UVB-irradiated oxidative DNA damage, apoptosis, and inflammation. • Quercitrin functions as an antioxidant against UVB-induced skin injuries.

Yin, Yuanqin [Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang (China); Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Li, Wenqi; Son, Young-Ok; Sun, Lijuan; Lu, Jian; Kim, Donghern; Wang, Xin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Yao, Hua [Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang (China); Wang, Lei; Pratheeshkumar, Poyil; Hitron, Andrew J. [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Luo, Jia [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY (United States); Gao, Ning [Department of Pharmacognos, College of Pharmacy, 3rd Military Medical University, Chongqing (China); Shi, Xianglin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States); Zhang, Zhuo, E-mail: zhuo.zhang@uky.edu [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY (United States)

2013-06-01T23:59:59.000Z

168

Method and apparatus to measure the depth of skin burns  

DOE Patents [OSTI]

A new device for measuring the depth of surface tissue burns based on the rate at which the skin temperature responds to a sudden differential temperature stimulus. This technique can be performed without physical contact with the burned tissue. In one implementation, time-dependent surface temperature data is taken from subsequent frames of a video signal from an infrared-sensitive video camera. When a thermal transient is created, e.g., by turning off a heat lamp directed at the skin surface, the following time-dependent surface temperature data can be used to determine the skin burn depth. Imaging and non-imaging versions of this device can be implemented, thereby enabling laboratory-quality skin burn depth imagers for hospitals as well as hand-held skin burn depth sensors the size of a small pocket flashlight for field use and triage.

Dickey, Fred M. (Albuquerque, NM); Holswade, Scott C. (Albuquerque, NM)

2002-01-01T23:59:59.000Z

169

Mechanistic investigation of skin barrier perturbation induced by surfactants in the presence of humectants  

E-Print Network [OSTI]

The stratum corneum (SC) of the skin functions as a barrier between the body and the environment. Surfactants such as Sodium Dodecyl Sulfate (SDS) are used in skin cleansers and in skin-care formulations because of their ...

Ghosh, Saswata

2007-01-01T23:59:59.000Z

170

E-Print Network 3.0 - avoidable skin cancers Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: avoidable skin cancers Page: << < 1 2 3 4 5 > >> 1 "Skin Cancer-What to Look For" Rochester Recreation Summary: "Skin Cancer- What to Look For"...

171

Skin Disease In Dermatomyositis -- What Patients And Their Families Often Want To Know  

E-Print Network [OSTI]

on the upper eyelids (heliotrope erythema), the cheeks ofcharacteristic violet (heliotrope) skin color seen in whitecharacteristic violet (heliotrope) skin color seen in white

Sontheimer, Richard D.

2002-01-01T23:59:59.000Z

172

autologous fibrin-based skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

173

atopic dermatitis-like skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

174

acinetobacter baumannii-associated skin: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Information Sciences Websites Summary: specialized sub- classes, namely "bikini" "porn" and "skin" "non-skin", respectively. The extracted pornographic image classifiers....

175

E-Print Network 3.0 - anomalous skin effect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AT 35 GHZ Summary: us well into the anomalous skin effect regime. To facilitate comparison with the static resistivity... , we have used the the anomalous skin effect formula...

176

Understanding B Cell Kinetics in Humans via Heavy Water Labeling Using Nonlinear Mixed Effects Models and Stochastic Approximation EM algorithms  

E-Print Network [OSTI]

Understanding B Cell Kinetics in Humans via Heavy Water Labeling Using Nonlinear Mixed Effects, 2010 #12;Abstract Heavy water labeling is an endogenous labeling technique for measuring kinetics synthesized during cell division. Therefore, heavy water labeling is suitable for human studies and has been

Goldman, Steven A.

177

U.S. Department of Energy Human Subjects Research Database (HSRD) A model for internal oversight and external transparency  

SciTech Connect (OSTI)

This poster introduces the Department of Energy (DOE) Human Subjects Research Database (HSRD), which contains information on all Department of Energy research projects involving human subjects that: are funded by DOE; are conducted in DOE facilities; are performed by DOE personnel; include current or former DOE or contract personnel.

Oak Ridge Institute for Science and Education (ORISE)

2012-12-12T23:59:59.000Z

178

Procter & Gamble and Temple University scientists model skin's makeup |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - SeptemberMicroneedles for4-16 FORPointsProcess for

179

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice  

SciTech Connect (OSTI)

Research highlights: {yields} Development of mouse overexpressing native human HSF1 in all tissues including CNS. {yields} HSF1 overexpression enhances heat shock response at whole-animal and cellular level. {yields} HSF1 overexpression protects from polyglutamine toxicity and favors aggresomes. {yields} HSF1 overexpression enhances proteostasis at the whole-animal and cellular level. -- Abstract: The heat shock response (HSR) is controlled by the master transcriptional regulator heat shock factor 1 (HSF1). HSF1 maintains proteostasis and resistance to stress through production of heat shock proteins (HSPs). No transgenic model exists that overexpresses HSF1 in tissues of the central nervous system (CNS). We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1{sup +/0}) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of HSP70 and 90 showed only mild tissue-specific changes; however, in response to forced exercise, the skeletal muscle HSR was more elevated in HSF1{sup +/0} mice compared to WT littermates and in fibroblasts following heat shock, as indicated by levels of inducible HSP70 mRNA and protein. HSF1{sup +/0} cells elicited a significantly more robust HSR in response to expression of the 82 repeat polyglutamine-YFP fusion construct (Q82YFP) and maintained proteasome-dependent processing of Q82YFP compared to WT fibroblasts. Overexpression of HSF1 was associated with fewer, but larger Q82YFP aggregates resembling aggresomes in HSF1{sup +/0} cells, and increased viability. Therefore, our data demonstrate that tissues and cells from mice overexpressing full-length non-mutant HSF1 exhibit enhanced proteostasis.

Pierce, Anson, E-mail: piercea2@uthscsa.edu [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States); Wei, Rochelle; Halade, Dipti [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States)] [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Yoo, Si-Eun [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Ran, Qitao; Richardson, Arlan [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States)

2010-11-05T23:59:59.000Z

180

allergic skin disease: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the microbiome...The Skin Microbiome in Healthy and Allergic Dogs Aline Rodrigues Hoffmann1*, Adam P. Patterson2, Alison Diesel2, Sara D. Lawhon4, Hoai Jaclyn Ly1, Christine...

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

allergic skin diseases: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of the microbiome...The Skin Microbiome in Healthy and Allergic Dogs Aline Rodrigues Hoffmann1*, Adam P. Patterson2, Alison Diesel2, Sara D. Lawhon4, Hoai Jaclyn Ly1, Christine...

182

SLUG TESTING IN WELLS WITH FINITE-THICKNESS SKIN  

SciTech Connect (OSTI)

We present an analysis of the slug test in a well surrounded by an annulus of altered material, which is treated as a skin of finite thickness. By assuming the skin has a thickness, the storage capacity of the altered material is included in the analysis. The problem is solved in the Laplace domain. The solution is found in terms of well-bore storage and the thickness, hydraulic conductivity, and specific storage of the skin. Type curves are generated by numerical inversion of the Laplace transform solution. We find that standard methods of analysis, involving a skin of infinitesimal thickness, are adequate for open-well or drill-stem tests. However, for pressurized tests the response may differ markedly from standard slug-test solutions.

Moench, A.F.; Hsieh

1985-01-22T23:59:59.000Z

183

Second Skin : motion capture with actuated feedback for motor learning  

E-Print Network [OSTI]

Second Skin aims to combine three-dimensional (3D) motion tracking with tactile feedback for the purpose of improving users' motor-learning ability. Such a system would track a user's body and limb movements as he or she ...

Miaw, Dennis (Dennis R.)

2010-01-01T23:59:59.000Z

184

acute skin reaction: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

from a complex reaction induced by plant pigments exposed to ultraviolet (UV) wave length sunlight in the skin of animals that have eaten certain plants 1-3. This reaction is...

185

attenuate skin dryness: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with ultra-low density and high thermal stability. The supersolidity of skin sliperizes ice. Xi Zhang; Yongli Huang; a Zengsheng Ma; Yichun Zhou; Chang Q Sun 2013-10-03 9 Journal...

186

artificial skin applications: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

with ultra-low density and high thermal stability. The supersolidity of skin sliperizes ice. Xi Zhang; Yongli Huang; a Zengsheng Ma; Yichun Zhou; Chang Q Sun 2013-10-03 117 An...

187

Involvement of TGF-beta in skin photoaging  

E-Print Network [OSTI]

The goal of this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major ...

Choi, Won Seon, 1975-

2005-01-01T23:59:59.000Z

188

Nuclear skin emergence in Skyrme deformed Hartree-Fock calculations  

E-Print Network [OSTI]

A study of the charge and matter densities and the corresponding rms radii for even-even isotopes of Ni, Kr, and Sn has been performed in the framework of deformed self-consistent mean field Skyrme HF+BCS method. The resulting charge radii and neutron skin thicknesses of these nuclei are compared with available experimental data, as well as with other theoretical predictions. The formation of a neutron skin, which manifests itself in an excess of neutrons at distances greater than the radius of the proton distribution, is analyzed in terms of various definitions. Formation of a proton skin is shown to be unlikely. The effects of deformation on the neutron skins in even-even deformed nuclei far from the stability line are discussed.

Sarriguren, P; de Guerra, E Moya; Antonov, A N

2007-01-01T23:59:59.000Z

189

Mpemba paradox: Hydrogen bond memory and water-skin supersolidity  

E-Print Network [OSTI]

Numerical reproduction of measurements, experimental evidence for skin super-solidity and hydrogen-bond memory clarified that Mpemba paradox integrates the heat emission-conduction-dissipation dynamics in the source-path-drain cycle system.

Chang Q Sun

2015-01-05T23:59:59.000Z

190

Carmichael's Concise Review Microscopy is Only Skin Deep  

E-Print Network [OSTI]

Carmichael's Concise Review Microscopy is Only Skin Deep Stephen W. Carmichael Mayo Clinic. Coming Events 2011 EMAS 2011 May 15­19, 2011 Angers, France www.emas-web.net IUMAS-V May 22­27, 2011

Heller, Eric

191

Fluorescent silica colloids for study and visualization of skin care products  

E-Print Network [OSTI]

due to long exposures to cold and dry air (7). Different skin care products are used to hy- drate dryFluorescent silica colloids for study and visualization of skin care products Swaminathan Iyer: The efficacy of skin care products depends on the time and dynamics of their absorbance by the skin, and its

Sokolov, Igor

192

A Supersolid Skin Covering both Water and Ice  

E-Print Network [OSTI]

The mysterious nature and functionality of water and ice skins remain baffling to the community since 1859 when Farady firstly proposed liquid skin lubricating ice. Here we show the presence of supersolid phase that covers both water and ice using Raman spectroscopy measurements and quantum calculations. In the skin of two molecular layers thick, molecular undercoordination shortens the H-O bond by ~16% and lengthens the OH nonbond by ~25% through repulsion between electron pairs on adjacent O atoms, which depresses the density from 0.92 for bulk ice to 0.75 gcm-3. The O:H-O cooperative relaxation stiffens the H-O stretching phonon from 3200/3150 cm-1 to the same value of 3450 cm-1 and raises the melting temperature of both skins by up to ~310 K. Numerical derivatives on the viscosity and charge accumulation suggests that the elastic, polarized, and thermally stable supersolid phase makes the ice frictionless and water skin hydrophobic and ice like at room temperature.

Sun, Chang Q

2014-01-01T23:59:59.000Z

193

Development of a combined model of tissue kinetics and radiation response of human bronchiolar epithelium with single cell resolution  

E-Print Network [OSTI]

Lack of accurate data for epidemiological studies of low dose radiation effects necessitates development of dosimetric models allowing prediction of cancer risks for different organs. The objective of this work is to develop a model of the radiation...

Ostrovskaya, Natela Grigoryevna

2006-10-30T23:59:59.000Z

194

Guest editorial: Special issue on human computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Pantic, Maja

195

Viability of adult rat skin following 13 Mev proton irradiation  

E-Print Network [OSTI]

then removed from suspension by centrifugation and washed twice in Smith's chick heart growth media. 33 All cells removed from the biopsy by this enzyme dissection were placed in culture to check viability. Two Rose chambers con- taining the first scraping... Dissipation . Diagram ? Proton Energy Dissipation 17 17 Cell Suspension Filter Tube. Exploded View of Rose Chamber 24 Rat 822, Gross Appearance 37 SB. Rat 822, Skin Section. 38 Rat 771, Gross Appearance 37 Rat 771, Skin Section. 38 7A. 7B. Rat 835...

Caraway, Bobby Lamar

1966-01-01T23:59:59.000Z

196

Development of an in vitro model of contraction by fibroblasts  

E-Print Network [OSTI]

Dermal scars in adult humans are mechanically and functionally inferior to normal skin and can be physically disfiguring. The contraction of the wound by fibroblasts has been linked to the formation of scar. The mechanical ...

Freyman, Toby M., 1974-

2001-01-01T23:59:59.000Z

197

Computational Modeling of Human Head Under Blast Shailesh Ganpule, Dr. Linxia Gu, Dr. Guoxin Cao, Dr.Namas Chandra  

E-Print Network [OSTI]

pressure, - reference density 0 - reference sound speed, s - slope of U curve0 - nominal volumetric compressive strain p H c Us p Helmet and skull: Linear Elastic Isotropic Density (kg/m3) Bulk Modulus (GPa constrained Load and Boundary Conditions Material model: Brain: SLS model Instantaneous Shear Modulus (k

Farritor, Shane

198

Subclonal variation and skin russeting in potato, (Solanum tuberosum L.)  

E-Print Network [OSTI]

of subclonal selection for putative russet skin mutations of 'Century Russet' was conducted in Texas and Colorado to improve the russeting character in 'Century Russet'. RAPD analysis of a segregating F I family derived from a russet x white cross and of three...

Oehlke, Leslie Lashaun

1997-01-01T23:59:59.000Z

199

PASSAGE OF FISSION PRODUCTS THROUGH THE SKIN OF TUNA  

E-Print Network [OSTI]

. Presumably, radio- active materials contaminating the skin of such fish could enter and spread through the tissues thus contaminating the whole fish. The present study intended to test this assump- tion, considers, resulting in small quantities in the tissues of tuna held in cold brine for as long as almost two months

200

A Solar Re-Skin at FedEx Field | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

A Solar Re-Skin at FedEx Field A Solar Re-Skin at FedEx Field August 2, 2011 - 10:40am Addthis Ramamoorthy Ramesh Former Director, SunShot Initiative & Solar Energy Technologies...

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

HandWave : design and manufacture of a wearable wireless skin conductance sensor and housing  

E-Print Network [OSTI]

This thesis report details the design and manufacture of HandWave, a wearable wireless Bluetooth skin conductance sensor, and dedicated housing. The HandWave collects Electrodermal Activity (EDA) data by measuring skin ...

Strauss, Marc D

2005-01-01T23:59:59.000Z

202

Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction  

E-Print Network [OSTI]

The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...

Li, Vivian V. (Vivian Victoria)

2008-01-01T23:59:59.000Z

203

E-Print Network 3.0 - age gender skin Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Kings Cross, London. 19 March 2011. 1 A Paper Negotiating with Skin BY YU-CHIEN WU The French... , there are also misgivings in response to her claim that 'skin is a mask of...

204

E-Print Network 3.0 - assessing skin dose Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by adding up all expo- Summary: or other sources. Most food is, in fact, free of dioxins and furans. 12;29 Estimating Skin Exposure Doses... and for children. Skin Exposure...

205

E-Print Network 3.0 - argentine peanut skins Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

are fed. Molasses are often used to enhance palatability. Both peanut skins... and bakery waste can be difficult to feed. Peanut skins are fluffy and nutrient content varies with...

206

Breathing, Laughing, Sneezing, Coughing: Model and Control of an Anatomically Inspired, Physically-Based Human Torso Simulation  

E-Print Network [OSTI]

cular control of the neck. ACM Transactions on Graphics (control abstraction. SIGGRAPH ’95: Proceedings of the 22nd annual conference on Computer graphics andControl for modeling anatomically inspired laughter using audio. ACM Transactions on Graphics (

DiLorenzo, Paul Carmen

2008-01-01T23:59:59.000Z

207

Human behaviour and ecosystem services in sustainable farming landscapes : an agent-based model of socio-ecological systems   

E-Print Network [OSTI]

on agents’ interactions at smaller scale. This approach is better suited to understanding and modelling complex socio-ecological systems, which emerge from individual actions, and therefore for developing tools which improve policy effectiveness. In recent...

Guillem, Eléonore E.

2012-11-29T23:59:59.000Z

208

Skin tone of targets, lineup type, and confidence levels in cross-racial identification  

E-Print Network [OSTI]

The current experiment investigated facial recognition memory for own and other-race faces. Two variations (light-skin and dark-skin) were presented for the Black targets. The purpose of this experiment was to observe the effect of skin variations...

Williamson, Jessica Lynne

2013-02-22T23:59:59.000Z

209

Skin cancer is the most com-mon form of cancer in the United  

E-Print Network [OSTI]

Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

210

Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)  

E-Print Network [OSTI]

Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

Massachusetts at Amherst, University of

211

The Effect of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin  

E-Print Network [OSTI]

The Effect of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin preserved as it travels across the skin. Our results suggest, then, that the propagation of surface waves of Surface Wave Propagation on Neural Responses to Vibration in Primate Glabrous Skin. PLoS ONE 7(2): e31203

Elias, Damian Octavio

212

Towards the modeling of mucus draining from human lung: role of airways deformation on air-mucus interaction  

E-Print Network [OSTI]

Chest physiotherapy is an empirical technique used to help secretions to get out of the lung whenever stagnation occurs. Although commonly used, little is known about the inner mechanisms of chest physiotherapy and controversies about its use are coming out regularly. Thus, a scientific validation of chest physiotherapy is needed to evaluate its effects on secretions. We setup a quasi-static numerical model of chest physiotherapy based on thorax and lung physiology and on their respective biophysics. We modeled the lung with an idealized deformable symmetric bifurcating tree. Bronchi and their inner fluids mechanics are assumed axisymmetric. Static data from the literature is used to build a model for the lung's mechanics. Secretions motion is the consequence of the shear constraints apply by the air flow. The input of the model is the pressure on the chest wall at each time, and the output is the bronchi geometry and air and secretions properties. In the limit of our model, we mimicked manual and mechanical ...

Mauroy, Benjamin; Pelca, Dominique; Fausser, Christian; Merckx, Jacques; Mitchell, Barrett R

2015-01-01T23:59:59.000Z

213

Game Theoretic Modelling of a Human Driver’s Steering Interaction with Vehicle Active Steering Collision Avoidance System  

E-Print Network [OSTI]

-Integral-Derivative (PID) control, Model Predictive Control (MPC) and Linear Quadratic Regulator (LQR). Particular attention here is given to the MPC and LQR which serve as the foundation of the distributed MPC and LQ dynamic optimization approaches to be described...

Na, Xiaoxiang; Cole, David J.

2014-11-10T23:59:59.000Z

214

Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis  

E-Print Network [OSTI]

-pyridyl]furan (DB868; CPD-007-10), in the vervet monkey model of first stage HAT. DB868 was well tolerated at a dose up to 30 mg/kg/day for 10 days, a cumulative dose of 300 mg/kg. Mean plasma levels of biomarkers indicative of liver injury (alanine...

Thutia, John K.; Wolf, Kristina K.; Murilla, Grace A.; Liu, Qiang; Mutuku, James N.; Chen, Yao; Bridges, Arlene S.; Mdachi, Raymond E.; Ismail, Mohamed A.; Ching, Shelley; Boykin, David W.; Hall, James E.; Tidwell, Richard R.; Paine, Mary F.; Burn, Reto; Wang, Michael Z.

2013-06-06T23:59:59.000Z

215

Elimination of influence of neutron-skin size difference of initial colliding nuclei in Pb+Pb collisions  

E-Print Network [OSTI]

Within an isospin- and momentum-dependent transport model using as an input nucleon density profiles from Hartree-Fock calculations based on a modified Skyrme-like (MSL) model, we study how to eliminate the influence of neutron-skin size difference of initial colliding nuclei in probing the nuclear symmetry energy. Within the current experimental uncertainty range of neutron-skin size of $^{208}$Pb, the Pb+Pb collisions are performed in semicentral and peripheral collisions with impact parameters of 5 and 9fm and at beam energies from 50 MeV/nucleon to 1000 MeV/nucleon, respectively. It is shown that combination of neutron and proton collective flows, i.e., neutron-proton differential elliptic flow, neutron-proton elliptic flow difference, neutron-proton differential transverse flow and neutron-proton transverse flow difference, can effectively eliminate the effects of neutron-skin size difference and thus can be as useful sensitive observables in probing nuclear matter symmetry energy in heavy-ion collisions...

Wei, Gao-Feng

2015-01-01T23:59:59.000Z

216

Merging Models and Biomonitoring Data to Characterize Sources andPathways of Human Exposure to Organophosphorous Pesticides in the SalinasValley of California  

SciTech Connect (OSTI)

By drawing on human biomonitoring data and limited environmental samples together with outputs from the CalTOX multimedia, multipathway source-to-dose model, we characterize cumulative intake of organophosphorous (OP) pesticides in an agricultural region of California. We assemble regional OP pesticide use, environmental sampling, and biological tissue monitoring data for a large and geographically dispersed population cohort of 592 pregnant Latina women in California (the CHAMACOS cohort). We then use CalTOX with regional pesticide usage data to estimate the magnitude and uncertainty of exposure and intake from local sources. We combine model estimates of intake from local sources with food intake based on national residue data to estimate for the CHAMACOS cohort cumulative median OP intake, which corresponds to expected levels of urinary dialkylphosphate (DAP) metabolite excretion for this cohort. From these results we develop premises about relative contributions from different sources and pathways of exposure. We evaluate these premises by comparing the magnitude and variation of DAPs in the CHAMACOS cohort with the whole U.S. population using data from the National Health and Nutrition Evaluation Survey (NHANES). This comparison supports the premise that in both populations diet is the common and dominant exposure pathway. Both the model results and biomarker comparison supports the observation that the CHAMACOS population has a statistically significant higher intake of OP pesticides that appears as an almost constant additional dose among all participants. We attribute the magnitude and small variance of this intake to non-dietary exposure in residences from local sources.

McKone, Thomas E.; Castorina, Rosemary; Kuwabara, Yu; Harnly,Martha E.; Eskenazi, Brenda; Bradman, Asa

2006-06-01T23:59:59.000Z

217

Photochemical Internalization of Bleomycin Before External-Beam Radiotherapy Improves Locoregional Control in a Human Sarcoma Model  

SciTech Connect (OSTI)

Purpose: The aim of this study was to explore the tumor growth response of the combination photochemical internalization and external-beam radiotherapy. Photochemical internalization is a technology to improve the utilization of therapeutic macromolecules in cancer therapy by photochemical release of endocytosed macromolecules into the cytosol. Methods and Materials: A human sarcoma xenograft TAX-1 was inoculated subcutaneously into nude mice. The photosensitizer AlPcS{sub 2a} and bleomycin were intraperitoneally administrated 48 h and 30 min, respectively, before diode laser light exposure at 670 nm (20 J/cm{sup 2}). Thirty minutes or 7 days after photochemical treatment, the animals were subjected to 4 Gy of ionizing radiation. Results: Using photochemical internalization of bleomycin as an adjunct to ionizing radiation increased the time to progression for the tumors from 17 to 33 days as compared with that observed with photodynamic therapy combined with ionizing radiation as well as for radiochemotherapy with bleomycin. The side effects observed when photochemical internalization of bleomycin was given shortly before ionizing radiation were eliminated by separating the treatment modalities in time. Conclusion: Photochemical internalization of bleomycin combined with ionizing radiation increased the time to progression and showed minimal toxicity and may therefore reduce the total radiation dose necessary to obtain local tumor control while avoiding long-term sequelae from radiotherapy.

Norum, Ole-Jacob, E-mail: oleno@radiumhospitalet.n [Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Department of Surgical Oncology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Bruland, Oyvind Sverre [Department of Oncology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Faculty of Clinical Medicine, University of Oslo, Oslo (Norway); Gorunova, Ludmila [Department of Medical Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Berg, Kristian [Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway)

2009-11-01T23:59:59.000Z

218

Lithium Ion Battery Performance of Silicon Nanowires With Carbon Skin  

SciTech Connect (OSTI)

Silicon (Si) nanomaterials have emerged as a leading candidate for next generation lithium-ion battery anodes. However, the low electrical conductivity of Si requires the use of conductive additives in the anode film. Here we report a solution-based synthesis of Si nanowires with a conductive carbon skin. Without any conductive additive, the Si nanowire electrodes exhibited capacities of over 2000 mA h g-1 for 100 cycles when cycled at C/10 and over 1200 mA h g-1 when cycled more rapidly at 1C against Li metal.. In situ transmission electron microscopy (TEM) observation reveals that the carbon skin performs dual roles: it speeds lithiation of the Si nanowires significantly, while also constraining the final volume expansion. The present work sheds light on ways to optimize lithium battery performance by smartly tailoring the nanostructure of composition of materials based on silicon and carbon.

Bogart, Timothy D.; Oka, Daichi; Lu, Xiaotang; Gu, Meng; Wang, Chong M.; Korgel, Brian A.

2013-12-06T23:59:59.000Z

219

Anomalous skin effects in a weakly magnetized degenerate electron plasma  

SciTech Connect (OSTI)

Fully relativistic analysis of anomalous skin effects for parallel propagating waves in a weakly magnetized degenerate electron plasma is presented and a graphical comparison is made with the results obtained using relativistic Maxwellian distribution function [G. Abbas, M. F. Bashir, and G. Murtaza, Phys. Plasmas 18, 102115 (2011)]. It is found that the penetration depth for R- and L-waves for degenerate case is qualitatively small in comparison with the Maxwellian plasma case. The quantitative reduction due to weak magnetic field in the skin depth in R-wave for degenerate plasma is large as compared to the non-degenerate one. By ignoring the ambient magnetic field, previous results for degenerate field free case are salvaged [A. F. Alexandrov, A. S. Bogdankevich, and A. A. Rukhadze, Principles of Plasma Electrodynamics (Springer-Verlag, Berlin/Heidelberg, 1984), p. 90].

Abbas, G., E-mail: gohar.abbas@gcu.edu.pk; Sarfraz, M. [Department of Physics, GC University Lahore, Katchery Road, Lahore 54000 (Pakistan); Shah, H. A. [Forman Christian College University, Farozpur Road, Lahore 54600 (Pakistan)

2014-09-15T23:59:59.000Z

220

Skin effect with arbitrary specularity in Maxwellian plasma  

E-Print Network [OSTI]

The problem of skin effect with arbitrary specularity in maxwellian plasma with specular--diffuse boundary conditions is solved. A new analytical method is developed that makes it possible to to obtain a solution up to an arbitrary degree of accuracy. The method is based on the idea of symmetric continuation not only the electric field, but also electron distribution function. The solution is obtained in a form of von Neumann series.

Anatoly V. Latyshev; Alexander A. Yushkanov

2009-12-10T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Beliefs about Human Extinction  

SciTech Connect (OSTI)

This paper presents the results of a web-based survey about futures issues. Among many questions, respondents were asked whether they believe humans will become extinct. Forty-five percent of the almost 600 respondents believe that humans will become extinct. Many of those holding this believe felt that humans could become extinct within 500-1000 years. Others estimated extinction 5000 or more years into the future. A logistic regression model was estimated to explore the bases for this belief. It was found that people who describe themselves a secular are more likely to hold this belief than people who describe themselves as being Protestant. Older respondents and those who believe that humans have little control over their future also hold this belief. In addition, people who are more apt to think about the future and are better able to imagine potential futures tend to also believe that humans will become extinct.

Tonn, Bruce Edward [ORNL

2009-11-01T23:59:59.000Z

222

The Production and Analysis of Biodiesel from Waste Chicken Skin and Pork Skin Fat and a Comparison of Fuel Properties to Petroleum Derived Diesel Fuel  

E-Print Network [OSTI]

Abstract—People today are increasingly health conscious and therefore shopkeepers tend to dispose of fatty chicken and pork skin. Chicken and pork skins thus are sources of solid waste that are usually not utilized. This paper deals with the production of useful biodiesel from utilizing the waste chicken and pork skins. Fat from the waste chicken and pork skins (sourced from local shops), was first extracted and subjected to transesterification. The products of transesterification were FAME (Fatty acid methyl esters) and glycerol. The FAME produced was tested for five parameters namely calorific value, pour point and cloud point when compared to ASTM E2515-11 standard values. Comparison of the obtained values of the five parameters with the standard values for diesel was performed to determine the viability of the biodiesel produced. The results of this experiment showed that the calorific values of FAME produced from chicken skin and pork skin fat were close to that of petroleum derived diesel. However, two test parameters namely kinematic viscosity and pour point differed when compared to diesel; this problem can be circumvented by modifying an automobile’s internal combustion engine. Due to the relatively high yield value of biodiesel, it is feasible to utilize chicken skin and pork skin fat at a rural level to produce FAME that can be an alternative to diesel in this time of acute fuel scarcity.

Krish T Bharat; Agni Bhattacharya

223

THERMAL INTERACTION OF CRYOGEN SPRAY WITH HUMAN SKIN UNDER VACUUM PRESSURES  

E-Print Network [OSTI]

During the treatment of port wine stain (PWS) birthmarks laser energy is irradiated at appropriate Riverside, Riverside, CA, 92521, USA. gaguilar@engr.ucr.edu Abstract. Clinical results of port wine stain of this procedure is that laser energy is also absorbed by epidermal melanin, causing localized heating therein

Aguilar, Guillermo

224

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation. |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces andMapping theEnergy Storage EnergyLaboratoryPortalTapping Into

225

Apparatus for testing skin samples or the like  

DOE Patents [OSTI]

An apparatus for testing the permeability of living skin samples has a flat base with a plurality of sample-holding cavities formed in its upper surface, the samples being placed in counterbores in the cavities with the epidermis uppermost. O-rings of Teflon washers are respectively placed on the samples and a flat cover is connected to the base to press the rings against the upper surfaces of the samples. Media to maintain tissue viability and recovery of metabolites is introduced into the lower portion of the sample-holding cavities through passages in the base. Test materials are introduced through holes in the cover plate after assembly of the chamber.

Holland, J.M.

1982-08-31T23:59:59.000Z

226

Simulating human behavior for national security human interactions.  

SciTech Connect (OSTI)

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

227

E-Print Network 3.0 - arsenic-related skin lesions Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

7 | July 2002 729 Family Correlations of Arsenic Methylation Patterns in Children and Parents Summary: various health effects, including can- cers of the bladder, skin, and...

228

Management of Pediatric Skin Abscesses in Pediatric, General Academic and Community Emergency Departments  

E-Print Network [OSTI]

Staphylococcus aureus (CA-MRSA) in skin abscesses presentingmeeting on management of MRSA in Conflicts of Interest: Byfor clinical management of MRSA in the community: Summary of

2011-01-01T23:59:59.000Z

229

Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection  

E-Print Network [OSTI]

3 vaccine efficacy in MRSA skin versus invasive infectionFig. 1) and suppression of MRSA proliferation (Fig. 2). Eachseverity and suppression of MRSA bioluminescence (Figs. 1

2014-01-01T23:59:59.000Z

230

E-Print Network 3.0 - arsenic skin lesions Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

who had a substantially increased risk of stillbirth... concentrations greater than 400 lgliter and also showed signs of arsenic-caused skin lesions were se- lected......

231

Radiation port dermatophytosis: Tinea corporis occurring at the site of irradiated skin  

E-Print Network [OSTI]

M, Huang J, Arous E: Radiation therapy toxicity to the skin.Radiation port dermatophytosis: Tinea corporis occurring atHouston, Texas Abstract Radiation port dermatophytosis is

Casamiquela, Kathleen M; Cohen, Philip R

2012-01-01T23:59:59.000Z

232

E-Print Network 3.0 - amphibian skin exposed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sciences and Ecology 6 Global biodiversity loss and the emergence of infec-tious diseases are two of the most pressing environ- Summary: ). Amphibians have permeable skin,...

233

E-Print Network 3.0 - acute skin toxicity Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: that bind to transthyretin, a thyroxine binding protein. 12;Toxicity of Dioxins Acute Toxicity Varies... skin Reproductive effects of not seen with glycols...

234

E-Print Network 3.0 - amphibian skin epithelium Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ulcers & bloating are keySkin... AmphibiansInfections in Wild Amphibians D. Earl Green, DVMD. Earl Green, DVM Department of Interior... % of larvae -- Onset is sudden...

235

E-Print Network 3.0 - artificial skin construct Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and applications, computer vision, adult-content detection, skin color detection Abstract: As more... a tremendous amount of manual work to construct (either directly, or...

236

THE EFFECTS OF HIV INFECTION ON THE EXPRESSION OF THE DRUG EFFLUX PROTEINS P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN IN A HUMAN INTESTINE MODEL  

E-Print Network [OSTI]

Background: Emerging evidence suggests poor antiretroviral penetration within human gastrointestinal (GI) tissues may contribute to HIV persistence within reservoirs despite effective therapy. We hypothesize that HIV ...

Ellis, Kelstan Lynch

2012-08-31T23:59:59.000Z

237

Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

an implementation of a single-fluid inter- face model in the ALE-AMR code to simulate surface tension effects. The model does not require explicit information on the physical...

238

Humans and models: converging ‘truths’  

E-Print Network [OSTI]

and accidental deaths among Cherokee Indians: a naturaland accidental deaths among Cherokee Indians in rural NorthIn our analysis of the Cherokee response to acute and large

Bruckner, Tim A; Margerison-Zilko, Claire

2011-01-01T23:59:59.000Z

239

Developing Human Performance Measures  

SciTech Connect (OSTI)

Through the reactor oversight process (ROP), the U.S. Nuclear Regulatory Commission (NRC) monitors the performance of utilities licensed to operate nuclear power plants. The process is designed to assure public health and safety by providing reasonable assurance that licensees are meeting the cornerstones of safety and designated crosscutting elements. The reactor inspection program, together with performance indicators (PIs), and enforcement activities form the basis for the NRC’s risk-informed, performance based regulatory framework. While human performance is a key component in the safe operation of nuclear power plants and is a designated cross-cutting element of the ROP, there is currently no direct inspection or performance indicator for assessing human performance. Rather, when human performance is identified as a substantive cross cutting element in any 1 of 3 categories (resources, organizational or personnel), it is then evaluated for common themes to determine if follow-up actions are warranted. However, variability in human performance occurs from day to day, across activities that vary in complexity, and workgroups, contributing to the uncertainty in the outcomes of performance. While some variability in human performance may be random, much of the variability may be attributed to factors that are not currently assessed. There is a need to identify and assess aspects of human performance that relate to plant safety and to develop measures that can be used to successfully assure licensee performance and indicate when additional investigation may be required. This paper presents research that establishes a technical basis for developing human performance measures. In particular, we discuss: 1) how historical data already gives some indication of connection between human performance and overall plant performance, 2) how industry led efforts to measure and model human performance and organizational factors could serve as a data source and basis for a framework, 3) how our use of modeling and simulation techniques could be used to develop and validate measures of human performance, and 4) what the possible outcomes are from this research as the modeling and simulation efforts generate results.

Jeffrey Joe; Bruce Hallbert; Larry Blackwood; Donald Dudehoeffer; Kent Hansen

2006-05-01T23:59:59.000Z

240

Dose Reconstruction Using Computational Modeling of Handling a Particular Arsenic-73/Arsenic-74 Source  

E-Print Network [OSTI]

the hand were obtained from International Commission on Radiation Protection (ICRP) Publication 110, Adult Reference Computational Phantoms (ICRP 2009). The thickness of the skin 12 layers used throughout the hand model was obtained from ICRP... Publication 89 and shown in Fig. 12 (ICRP 2002). The thickness of the outer skin, or dead skin layer, was modeled as 0.0069 cm so that the 7 mg cm-2 skin depth could be thick enough (0.0002 cm) to tally in MCNP. The approximate length and width...

Stallard, Alisha M.

2011-08-08T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

The oncogenic action of ionizing radiation on rat skin  

SciTech Connect (OSTI)

The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of [sup 14]C-thymidine. The return of these cells to S-phase a second time was detected by a second label ([sup 3]H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The [sup 14]C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with [sup 14]C increased after 42 hr and remained relatively constant thereafter.

Burns, F.J.; Garte, S.J.

1992-01-01T23:59:59.000Z

242

Recently, doctors in Texas have been seeing an increasing number of patients with skin  

E-Print Network [OSTI]

that kill bacteria), also called methicillin-resistant Staphylococcus aureus-- "MRSA." The Texas Department this is happening and how to prevent antibiotic (drug) resistant Staph/MRSA skin infections from spreading. What is a Staph/MRSA skin infection? It can be a pimple, rash, boil, or an open wound. Staph/MRSA is often

243

HEAT TRANSFERS IN A DOUBLE SKIN ROOF VENTILATED BY NATURAL CONVECTION IN SUMMER TIME  

E-Print Network [OSTI]

1 HEAT TRANSFERS IN A DOUBLE SKIN ROOF VENTILATED BY NATURAL CONVECTION IN SUMMER TIME P. H or in tropical and arid countries. In this work, radiation, convection and conduction heat transfers-dimensional numerical simulation of the heat transfers through the double skin reveals the most important parameters

Boyer, Edmond

244

Density dependence of the symmetry energy from neutron skin thickness in finite nuclei  

SciTech Connect (OSTI)

The density dependence of the symmetry energy, characterized by the parameter L, is studied using information provided by the neutron skin thickness in finite nuclei. An estimate of L is obtained from experimental data of antiprotonic atoms. We also discuss the ability of parity violating electron scatering to obtain information about the neutron skin thickness in {sup 208}Pb.

Vinas, X.; Centelles, M.; Roca-Maza, X.; Warda, M. [Departament d'Estructura i Conastituents de la Materia and Institut de Ciencies del Cosmos, Facultat de Fisica, Universitat de Barcelona, Marti i Franques 1, 08028, Barcelona (Spain); Instituto Nazionale di Fisica Nucleare, Sezione di Milano , Via Celoria 16, I-20133 Milano (Italy); Katedra Fizyki Teoretycznej, Uniwersytet Marii Curie-Skodowskiej ul. Radziszewskiego 10, 20-031 Lublin (Poland)

2012-10-20T23:59:59.000Z

245

Automatic Skin Enhancement with Visible and Near-Infrared Image Fusion  

E-Print Network [OSTI]

Automatic Skin Enhancement with Visible and Near-Infrared Image Fusion Sabine Süsstrunk School and hemo- globin, the key components of skin color, have little absorp- tion in the near-infrared (NIR to the incident light's wavelength, we show that near-infrared images provide information that can be used

Salvaggio, Carl

246

Towards a Minimal Architecture for a Printable, Modular, and Robust Sensing Skin  

E-Print Network [OSTI]

. Bachrach, and R.S. Fearing Abstract-- This work presents a low-complexity modular sensor grid architecture to provide a smart skin to non-convex shapes, such as a robot body and legs. To configure a sensing skin shaped by arbitrary cuts and rapid changes in designs, we use a wavefront planning approach to generate

Fearing, Ron

247

Associations Between Drinking Water and Urinary Arsenic Levels and Skin Lesions in  

E-Print Network [OSTI]

Associations Between Drinking Water and Urinary Arsenic Levels and Skin Lesions in Bangladesh Graziano, PhD The present study examined the associations between drinking water and urinary arsenic levels currently drinking water containing concentrations of arsenic 50 g/L. The risk for skin lesions in relation

van Geen, Alexander

248

Arsenic in Drinking Water and Skin Lesions: Dose-Response Data from West Bengal, India  

E-Print Network [OSTI]

Arsenic in Drinking Water and Skin Lesions: Dose-Response Data from West Bengal, India Reina Haque the dose-re- sponse relation between low arsenic concentrations in drinking water and arsenic-induced skin peak arsenic concentration in drinking water was 325 g/liter for cases and 180 g/liter for controls

California at Berkeley, University of

249

Forensic identification using skin bacterial communities Noah Fierera,b,1  

E-Print Network [OSTI]

Forensic identification using skin bacterial communities Noah Fierera,b,1 , Christian L. Lauberb are personalized, we hypothesized that we could use the residual skin bacteria left on objects for forensic approach, this series ofstudies introducesa forensics approach that could eventually be used

Fierer, Noah

250

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog  

SciTech Connect (OSTI)

Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a well-known DNA-damaging agent that has been used in chemical warfare since World War I, and is a weapon that could potentially be used in a terrorist attack on a civilian population. Dermal exposure to high concentrations of SM produces severe, long-lasting burns. Topical exposure to high concentrations of 2-(chloroethyl) ethyl sulfide (CEES), a monofunctional analog of SM, also produces severe skin lesions in mice. Utilizing a genetically engineered mouse strain, Big Blue, that allows measurement of mutation frequencies in mouse tissues, we now show that topical treatment with much lower concentrations of CEES induces significant dose- and time-dependent increases in mutation frequency in mouse skin; the mutagenic exposures produce minimal toxicity as determined by standard histopathology and immunohistochemical analysis for cytokeratin 6 and the DNA-damage induced phosphorylation of histone H2AX (?-H2AX). We attempted to develop a therapeutic that would inhibit the CEES-induced increase in mutation frequency in the skin. We observe that multi-dose, topical treatment with 2,6-dithiopurine (DTP), a known chemical scavenger of CEES, beginning 1 h post-exposure to CEES, completely abolishes the CEES-induced increase in mutation frequency. These findings suggest the possibility that DTP, previously shown to be non-toxic in mice, may be useful as a therapeutic agent in accidental or malicious human exposures to SM. -- Highlights: ? 200 mM 2-(chloroethyl) ethyl sulfide (CEES) induces mutations in mouse skin. ? This dose of CEES is not overtly toxic, as assayed by histopathology. ? 2,6-Dithiopurine (DTP), applied after CEES-treatment, abolishes CEES-mutagenesis. ? This supports the idea that sulfur mustards exhibit long biological half-lives.

Boulware, Stephen [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); Fields, Tammy; McIvor, Elizabeth; Powell, K. Leslie; Abel, Erika L. [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)] [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States); Vasquez, Karen M. [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); MacLeod, Michael C., E-mail: mcmacleod@mdanderson.org [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)

2012-09-01T23:59:59.000Z

251

Human Ecology Human ecology Research  

E-Print Network [OSTI]

Channel, Latin America. STUDIOS Architecture. #12;HUMAN ECOLOGY · APRIL 2005 1 Lisa Staiano-Coico, Ph Frey spins a green alternative for textiles. Fibers from rapidly renewable materials

Wang, Z. Jane

252

Deep Beams and Slabs The purpose of skin reinforcement in a deep beam is to limit the  

E-Print Network [OSTI]

Deep Beams and Slabs Deep Beams The purpose of skin reinforcement in a deep beam is to limit require different amounts of skin reinforcement. The purpose of our experiment is to compare beams designed with the different amounts of skin reinforcement required by these codes. 3 deep beams following

Barthelat, Francois

253

Combining visible and near-infrared images for realistic skin Clement Fredembach, Nathalie Barbuscia and Sabine Susstrunk  

E-Print Network [OSTI]

Combining visible and near-infrared images for realistic skin smoothing Cl´ement Fredembach components of skin colour, have little absorption in the near-infrared part of the spectrum propose that near-infrared images provide information that can be used to automatically smooth skin tones

Salvaggio, Carl

254

Genetic Background Modulates Gene Expression Profile Induced by Skin Irradiation in Ptch1 Mice  

SciTech Connect (OSTI)

Purpose: Ptch1 germ-line mutations in mice predispose to radiation-induced basal cell carcinoma of the skin, with tumor incidence modulated by the genetic background. Here, we examined the possible mechanisms underlying skin response to radiation in F1 progeny of Ptch1{sup neo67/+} mice crossed with either skin tumor-susceptible (Car-S) or -resistant (Car-R) mice and X-irradiated (3 Gy) at 2 days of age or left untreated. Methods and Materials: We conducted a gene expression profile analysis in mRNA samples extracted from the skin of irradiated or control mice, using Affymetrix whole mouse genome expression array. Confirmation of the results was done using real-time reverse-transcriptase polymerase chain reaction. Results: Analysis of the gene expression profile of normal skin of F1 mice at 4 weeks of age revealed a similar basal profile in the nonirradiated mice, but alterations in levels of 71 transcripts in irradiated Ptch1{sup neo67/+} mice of the Car-R cross and modulation of only eight genes in irradiated Ptch1{sup neo67/+} mice of the Car-S cross. Conclusions: These results indicate that neonatal irradiation causes a persistent change in the gene expression profile of the skin. The tendency of mice genetically resistant to skin tumorigenesis to show a more complex pattern of transcriptional response to radiation than do genetically susceptible mice suggests a role for this response in genetic resistance to basal cell tumorigenesis.

Galvan, Antonella; Noci, Sara [Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy); Mancuso, Mariateresa; Pazzaglia, Simonetta; Saran, Anna [ENEA Laboratories, Rome (Italy); Dragani, Tommaso A. [Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy)], E-mail: tommaso.dragani@istitutotumori.mi.it

2008-12-01T23:59:59.000Z

255

Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a single-fluid diffuse interface model in the ALE-AMR hydrodynamics code to simulate surface tension effects. We show simula- tions and compare them to other surface tension...

256

Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

sion effects. We show the result of a test case, and compare it to the result without surface tension. The model describes droplet formation nicely. Application The ARRA-funded...

257

The second skin approach : skin strain field analysis and mechanical counter pressure prototyping for advanced spacesuit design  

E-Print Network [OSTI]

The primary aim of this thesis is to advance the theory of advanced locomotion mechanical counter pressure (MCP) spacesuits by studying the changes in the human body shape during joint motion. Two experiments take advantage ...

Bethke, Kristen (Kristen Ann)

2005-01-01T23:59:59.000Z

258

Human hybrid hybridoma  

SciTech Connect (OSTI)

Hybrid hybridomas are obtained by fusion of two cells, each producing its own antibody. Several authors have reported the construction of murine hybrid hybridomas with the aim to obtain bispecific monoclonal antibodies. The authors have investigated, in a model system, the feasibility of constructing a human hybrid hybridoma. They fused two monoclonal cell lines: an ouabain-sensitive and azaserine/hypoxanthine-resistant Epstein-Barr virus-transformed human cell line that produces an IgG1kappa antibody directed against tetanus toxiod and an azaserine/hypoxanthine-sensitive and ouabain-resistant human-mouse xenohybrid cell line that produces a human IgG1lambda antibody directed against hepatitis-B surface antigen. Hybrid hybridoma cells were selected in culture medium containing azaserine/hypoxanthine and ouabain. The hybrid nature of the secreted antibodies was analyzed by means of two antigen-specific immunoassay. The results show that it is possible, with the combined use of transformation and xenohybridization techniques, to construct human hybrid hybridomas that produce bispecific antibodies. Bispecific antibodies activity was measured by means of two radioimmunoassays.

Tiebout, R.F.; van Boxtel-Oosterhof, F.; Stricker, E.A.M.; Zeijlemaker, W.P.

1987-11-15T23:59:59.000Z

259

Digital Human Symposium 2009 March 12th, 2009  

E-Print Network [OSTI]

, resulting in autonomous pedestrian models, and (2) a comprehen- sive biomechanical model of the human body of the human body, its detailed biomechanical modeling has not received ad- equate attention. I will describe to synthesize autonomous movements for the behavioral animation of the human head and face. 2. Autonomous

Terzopoulos, Demetri

260

A common supersolid low-density skin sliperizing ice and toughening water surface  

E-Print Network [OSTI]

Skins of water and ice share the same attribute of supersolidity characterized by the identical H-O vibration frequency of 3450 cm-1. Molecular undercoordination and inter-electron-pair repulsion shortens the H-O bond and lengthen the O:H nonbond, leading to a dual process of nonbonding electron polarization. This relaxation-polarization process enhances the dipole moment, elasticity,viscosity, thermal stability of these skins with 25% density loss, which is responsible for the hydrophobicity and toughness of water skin and for the slippery of ice.

Xi Zhang; Yongli Huang; Zengsheng Ma; Yichun Zhou; Weitao Zheng; Ji Zhou; Chang Q. Sun

2014-08-15T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Sensitivity of the electric dipole polarizability to the neutron skin thickness in {sup 208}Pb  

SciTech Connect (OSTI)

The static dipole polarizability, {alpha}{sub D}, in {sup 208}Pb has been recently measured with highresolution via proton inelastic scattering at the Research Center for Nuclear Physics (RCNP) [1]. This observable is thought to be intimately connected with the neutron skin thickness, r{sub skin}, of the same nucleus and, more fundamentally, it is believed to be associated with the density dependence of the nuclear symmetry energy. The impact of r{sub skin} on {alpha}{sub D} in {sup 208}Pb is investigated and discussed on the basis of a large and representative set of relativistic and non-relativistic nuclear energy density functionals (EDF) [2].

Roca-Maza, X.; Agrawal, B. K.; Colo, G.; Nazarewicz, W.; Paar, N.; Piekarewicz, J.; Reinhard, P.-G.; Vretenar, D. [INFN, sezione di Milano, via Celoria 16, I-20133 Milano (Italy); Saha Institute of Nuclear Physics, Kolkata 700064 (India); Dipartimento di Fisica, Universita degli Studi di Milano and INFN, Sezione di Milano, 20133 Milano (Italy); Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996 (United States) and Institute of Theoretical Physics, University of Warsaw, Hoza 69, PL-00-681 Warsaw (Poland); Physics Department, Faculty of Science, University of Zagreb, Zagreb (Croatia); Department of Physics, Florida State University, Tallahassee, FL 32306 (United States); Institut fuer Theoretische Physik II, Universitaet Erlangen-Nuernberg, Staudtstrasse 7, D-91058 Erlangen (Germany); Physics Department, Faculty of Science, University of Zagreb, Zagreb (Croatia)

2012-10-20T23:59:59.000Z

262

Modelling  

E-Print Network [OSTI]

Modeling of technical machines became a standard technique since computer became powerful enough to handle the amount of data relevant to the specific system. Simulation of an existing physical device requires the knowledge of all relevant quantities. Electric fields given by the surrounding boundary as well as magnetic fields caused by coils or permanent magnets have to be known. Internal sources for both fields are sometimes taken into account, such as space charge forces or the internal magnetic field of a moving bunch of charged particles. Used solver routines are briefly described and some bench-marking is shown to estimate necessary computing times for different problems. Different types of charged particle sources will be shown together with a suitable model to describe the physical model. Electron guns are covered as well as different ion sources (volume ion sources, laser ion sources, Penning ion sources, electron resonance ion sources, and H$^-$-sources) together with some remarks on beam transport.

Spädtke, P

2013-01-01T23:59:59.000Z

263

Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid  

SciTech Connect (OSTI)

The metabolic series (family) approach for risk assessment uses a dosimetry-based analysis to develop toxicity information for a group of metabolically linked compounds using pharmacokinetic (PK) data for each compound and toxicity data for the parent compound. An initial physiologically-based pharmacokinetic (PBPK) model was developed to support the implementation of the metabolic series approach for n-butyl acetate and its subsequent metabolites, n-butanol, and n-butyric acid (the butyl series) (Barton et al. 2000). In conjunction with pilot pharmacokinetic studies, the model was used to design the definitive intravenous (i.v.) PK studies. Rats were implanted with dual indwelling cannulae and administered test compounds by i.v. bolus dose, i.v. infusion, or by inhalation in a recirculating closed chamber. Hepatic, vascular and extravascular metabolic constants for metabolism were estimated by fitting the model to the blood time course data from these experiments. The respiratory bioavailability of n-butyl acetate and n-butanol was estimated from closed chamber inhalation studies and measured ventilation rates. The resulting butyl series PBPK model successfully reproduces the blood time course of these compounds following i.v. administration, and inhalation exposure to n-butyl acetate and n-butanol. A fully scaled human version of the model successfully reproduces arterial blood n-butanol kinetics following inhalation exposure to n-butanol. These validated i.v (rat) and inhalation route models (rat, butyl acetate, n-butanol; human, butanol only) can be used to support species and dose-route extrapolations required for risk assessment of butyl series family of compounds. Further, this work demonstrates the usefulness of i.v. kinetic data for parameterization of systemic metabolism and the value of collaboration between experimentalists and kineticists in the development of PBPK models. The product of this effort, validated rat and human PBPK models for the butyl series compounds, illustrates the effectiveness of broad multi-institutional public/private collaborations in the pursuit of developing state of the art tools for risk assessment.

Teeguarden, Justin G.; Deisinger, P. J.; Poet, Torka S.; English, J C.; Faber, W D.; Barton, H. A.; Corley, Rick A.; Clewell, III, H. J.

2005-05-01T23:59:59.000Z

264

In Vivo characterization of skin using a weiner nonlinear stochastic identification method  

E-Print Network [OSTI]

This paper describes an indentometer device used to identify the linear dynamic and nonlinear properties of skin and underlying tissue using an in vivo test. The device uses a Lorentz force actuator to apply a dynamic force ...

Chen, Yi

265

E-Print Network 3.0 - allergic skin inflammation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tetrakis(dimethylamino)hafnium P-6280-B Date: February 2005 Copyright 2002, 2004-2005, Praxair Technology, Inc. Page 1 of 8 Summary: dermatitis (inflammation of the skin). With...

266

Is the duration of skin disease visits decreasing in the united states?  

E-Print Network [OSTI]

on fridays. J Dermatolog Treat 2013 Dec;24(6):405-7. [PMID:treatment. J Dermatolog Treat 2014 Dec;25(6):453-8. [PMID:Although non-dermatologists treat about half of all skin

Davis, Scott A; Feldman, Steven R; Fleischer Jr., Alan B

2015-01-01T23:59:59.000Z

267

FATIGUE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES  

E-Print Network [OSTI]

FATIGUE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES by Robert B in the Instron and Composite Laboratories toward the end of the experimental research. Finally, special thanks

268

Meeting report for the 1st skin microbiota workshop, Boulder, CO October 15-16 2012  

E-Print Network [OSTI]

This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The workshop was arranged to bring Department of Defense personnel together with experts in microbial ecology, ...

Gilbert, Jack A

269

A Systematic Study of Matrix Acidizing Treatments Using Skin Monitoring Method  

E-Print Network [OSTI]

The goal of this work was to evaluate matrix acidizing treatments of vertical and horizontal wells in carbonate reservoirs. Twenty field cases for acidizing treatments were analyzed by evaluating the skin factor evolution from on-site rate...

Pandya, Nimish

2012-07-16T23:59:59.000Z

270

Symmetry energy, neutron skin, and neutron star radius from chiral effective field theory interactions  

E-Print Network [OSTI]

We discuss neutron matter calculations based on chiral effective field theory interactions and their predictions for the symmetry energy, the neutron skin of 208 Pb, and for the radius of neutron stars.

K. Hebeler; A. Schwenk

2014-01-22T23:59:59.000Z

271

FRACTURE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES  

E-Print Network [OSTI]

FRACTURE OF SKIN-STIFFENER INTERSECTIONS IN COMPOSITE WIND TURBINE BLADE STRUCTURES by Darrin John to the other graduate students in the composite materials group for your smiles and friendships over the past Material .........................................................................................10

272

Design and fabrication of an optical pressure micro sensor for skin mechanics studies  

E-Print Network [OSTI]

The mechanics of skin is as central to touch as optics is to vision and acoustics is to hearing. With the advent of novel imaging technologies such as the Optical Coherence Tomography (OCT), we are now able to view structures ...

Kumar, Siddarth

2006-01-01T23:59:59.000Z

273

Hair follicles are required for optimal growth during lateral skin expansion   

E-Print Network [OSTI]

The hair follicles and the interfollicular epidermis of intact mature skin are maintained by distinct stem cell populations. Upon wounding, however, emigration of hair follicle keratinocytes to the interfollicular epidermis plays a role in acute...

Heath, Jack; Langton, Abigail K.; Hammond, Nigel L.; Dixon, Michael J.; Overbeek, Paul A.

2009-01-01T23:59:59.000Z

274

CS 4317 Human-Computer Interaction Course Number: CS4317  

E-Print Network [OSTI]

interaction. Theory of human-computer interaction. Development methods for interfaces such as user1 CS 4317 Human-Computer Interaction Course Number: CS4317 Course Title: Human-Computer Interaction Course Instructors Nigel Ward Course Description: CS4317: Models and methods of human-computer

Ward, Karen

275

aggressive skin malignancy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

relative to the external surfaces of the vehicle. Data on physical vehicle properties by field measurement were collected for 73 distinct makes and models of vehicles for which a...

276

Illusory Sense of Human Touch from a Warm and Soft Artificial Hand  

E-Print Network [OSTI]

To touch and be touched are vital to human development, well being, and relationships. However, to those who have lost their arms and hands due to accident or war, touching becomes a serious concern that often leads to psychosocial issues and social stigma. In this paper, we demonstrate that the touch from a warm and soft rubber hand can be perceived by another person as if the touch were coming from a human hand. We describe a three step process toward this goal. First, we made participants select artificial skin samples according to their preferred warmth and softness characteristics. At room temperature, the preferred warmth was found to be 28.4 deg C at the skin surface of a soft silicone rubber material that has a Shore durometer value of 30 at the OO scale. Second, we developed a process to create a rubber hand replica of a human hand. To compare the skin softness of a human hand and artificial hands, a robotic indenter was employed to produce a softness map by recording the displacement data when const...

Cabibihan, John-John; Srinivasa, Yeshwin Mysore; Chan, Mark Aaron; Muruganantham, Arrchana

2015-01-01T23:59:59.000Z

277

adult human muscle: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Human Muscle Fatigue Model in Dynamic Motions Computer Technologies and Information Sciences Websites Summary: Human Muscle...

278

A subliminal manipulation of the Extended Parallel Process Model  

E-Print Network [OSTI]

the context of skin cancer. The goals of this study were to (1) assess the effects of subliminal embeds as fear appeals (2) within the framework of the Extended Parallel Process Model, the EPPM (Witte, 1992a). While this study demonstrated that subliminal... go unnoticed by individuals (Dixon, 1981). To extend the inquiry into subliminal message processing, this project places embedded pictures (a form of subliminal research) in the context of skin cancer This thesis uses the style of mm ni ' n...

Stephenson, Michael Taylor

1993-01-01T23:59:59.000Z

279

In vivo 3D modeling of the femoropopliteal artery in human subjects based on x-ray angiography: Methodology and validation  

SciTech Connect (OSTI)

Endovascular revascularization of the femoropopliteal (FP) artery has been limited by high rates of restenosis and stent fracture. The unique physical forces that are applied to the FP artery during leg movement have been implicated in these phenomena. The foundation for measuring the effects of physical forces on the FP artery in a clinically relevant environment is based on the ability to develop 3D models of this vessel in different leg positions in vivo in patients with peripheral arterial disease (PAD). By acquiring paired angiographic images of the FP artery, and using angiography-based 3D modeling algorithms previously validated in the coronary arteries, the authors generated 3D models of ten FP arteries in nine patients with PAD with the lower extremity in straight leg (SL) and crossed leg (CL) positions. Due to the length of the FP artery, overlapping paired angiographic images of the entire FP artery were required to image the entire vessel, which necessitated the development of a novel fusion process in order to generate a 3D model of the entire FP artery. The methodology of angiographic acquisition and 3D model generation of the FP artery is described. In a subset of patients, a third angiographic view (i.e., validation view) was acquired in addition to the standard paired views for the purpose of validating the 3D modeling process. The mean root-mean-square (rms) error of the point-to-point distances between the centerline of the main FP artery from the 2D validation view and the centerline from the 3D model placed in the validation view for the SL and CL positions were 0.93{+-}0.19 mm and 1.12{+-}0.25 mm, respectively. Similarly, the mean rms error of the same comparison for the main FP artery and sidebranches for the SL and CL positions were 1.09{+-}0.38 mm and 1.21{+-}0.25 mm, respectively. A separate validation of the novel fusion process was performed by comparing the 3D model of the FP artery derived from fusion of 3D models of adjacent FP segments with the 2D validation view incorporating the region of fusion. The mean rms error of vessel centerline points of the main FP artery, the main FP artery plus directly connected sidebranches, and the mean rms error of upstream, downstream, and sidebranch directional vectors at bifurcation points in the overlap region were 1.41{+-}0.79 mm, 2.13{+-}1.12 mm, 3.16{+-}3.72 deg., 3.60{+-}5.39 deg., and 8.68{+-}8.42 deg. in the SL position, respectively, and 1.29{+-}0.35 mm, 1.61{+-}0.78 mm, 4.68{+-}4.08 deg., 3.41{+-}2.23 deg., and 5.52{+-}4.41 deg. in the CL position, respectively. Inter- and intraobserver variability in the generation of 3D models of individual FP segments and the fusion of overlapping FP segments were assessed. The mean rms errors between the centerlines of nine 3D models of individual FP segments generated by two independent observers, and repeated measurement by the same observer were 2.78{+-}1.26 mm and 3.50{+-}1.15 mm, respectively. The mean rms errors between the centerline of four 3D models of fused overlapping FP segments generated by two independent observers, and repeated measurement by the same observer were 4.99{+-}0.99 mm and 5.98{+-}1.22 mm, respectively. This study documents the ability to generate 3D models of the entire FP artery in vivo in patients with PAD in both SL and CL positions using routine angiography, and validates the methodologies used.

Klein, Andrew J.; Casserly, Ivan P.; Messenger, John C.; Carroll, John D.; Chen, S.-Y. James [University of Colorado Denver, Aurora, Colorado 80045 (United States); University of Colorado Denver, Aurora, Colorado 80045 and Denver VA Medical Center, Denver, Colorado 80220 (United States); University of Colorado Denver, Aurora, Colorado 80045 (United States)

2009-02-15T23:59:59.000Z

280

Limitations of the TG-43 formalism for skin high-dose-rate brachytherapy dose calculations  

SciTech Connect (OSTI)

Purpose: In skin high-dose-rate (HDR) brachytherapy, sources are located outside, in contact with, or implanted at some depth below the skin surface. Most treatment planning systems use the TG-43 formalism, which is based on single-source dose superposition within an infinite water medium without accounting for the true geometry in which conditions for scattered radiation are altered by the presence of air. The purpose of this study is to evaluate the dosimetric limitations of the TG-43 formalism in HDR skin brachytherapy and the potential clinical impact. Methods: Dose rate distributions of typical configurations used in skin brachytherapy were obtained: a 5 cm × 5 cm superficial mould; a source inside a catheter located at the skin surface with and without backscatter bolus; and a typical interstitial implant consisting of an HDR source in a catheter located at a depth of 0.5 cm. Commercially available HDR{sup 60}Co and {sup 192}Ir sources and a hypothetical {sup 169}Yb source were considered. The Geant4 Monte Carlo radiation transport code was used to estimate dose rate distributions for the configurations considered. These results were then compared to those obtained with the TG-43 dose calculation formalism. In particular, the influence of adding bolus material over the implant was studied. Results: For a 5 cm × 5 cm{sup 192}Ir superficial mould and 0.5 cm prescription depth, dose differences in comparison to the TG-43 method were about ?3%. When the source was positioned at the skin surface, dose differences were smaller than ?1% for {sup 60}Co and {sup 192}Ir, yet ?3% for {sup 169}Yb. For the interstitial implant, dose differences at the skin surface were ?7% for {sup 60}Co, ?0.6% for {sup 192}Ir, and ?2.5% for {sup 169}Yb. Conclusions: This study indicates the following: (i) for the superficial mould, no bolus is needed; (ii) when the source is in contact with the skin surface, no bolus is needed for either {sup 60}Co and {sup 192}Ir. For lower energy radionuclides like {sup 169}Yb, bolus may be needed; and (iii) for the interstitial case, at least a 0.1 cm bolus is advised for {sup 60}Co to avoid underdosing superficial target layers. For {sup 192}Ir and {sup 169}Yb, no bolus is needed. For those cases where no bolus is needed, its use might be detrimental as the lack of radiation scatter may be beneficial to the patient, although the 2% tolerance for dose calculation accuracy recommended in the AAPM TG-56 report is not fulfilled.

Granero, Domingo, E-mail: dgranero@eresa.com [Department of Radiation Physics, ERESA, Hospital General Universitario, 46014 Valencia (Spain)] [Department of Radiation Physics, ERESA, Hospital General Universitario, 46014 Valencia (Spain); Perez-Calatayud, Jose [Radiotherapy Department, La Fe University and Polytechnic Hospital, Valencia 46026 (Spain)] [Radiotherapy Department, La Fe University and Polytechnic Hospital, Valencia 46026 (Spain); Vijande, Javier [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100, Spain and IFIC (UV-CSIC), Paterna 46980 (Spain)] [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100, Spain and IFIC (UV-CSIC), Paterna 46980 (Spain); Ballester, Facundo [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain)] [Department of Atomic, Molecular and Nuclear Physics, University of Valencia, Burjassot 46100 (Spain); Rivard, Mark J. [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)] [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States)

2014-02-15T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Chronic cellular responses of rat skin to 13 Mev proton irradiation  

E-Print Network [OSTI]

CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

Hinkle, Donald King

1966-01-01T23:59:59.000Z

282

New Electronic Sensors Stick to Your Skin -Heart Rate Monitors -Popular Mechanics http://www.popularmechanics.com/science/health/breakthroughs/new-electronic-sensors-stick-to-your-skin?click=pm_latest[8/14/2011 5:59:45 AM  

E-Print Network [OSTI]

New Electronic Sensors Stick to Your Skin - Heart Rate Monitors - Popular Mechanics http://www Electronic Sensors That Stick to Your Skin Like Temporary Tattoos Nice tattoo. Or is it a heart-rate monitor to measure the electrical activity of the heart, muscles and brain. And using the same principles behind

Rogers, John A.

283

Department of Mechanical Engineering Fall 2012 Intelligent Building Skin Design  

E-Print Network [OSTI]

% reduction in solar heat gain The discretised polarizing sheet design is able to retrofit onto older. Additionally, we were tasked to evaluate Autodesk's software suite and its effectiveness in our design process of the prototype Used Autodesk Vasari to run solar analysis on the model of Rec Hall Fabricated a working scale

Demirel, Melik C.

284

Numerical Modelling of Combined Heat Transfers in a Double Skin Faade -Full Scale Laboratory  

E-Print Network [OSTI]

, thermal comfort, visual comfort or energy gain [1]. In the current context of global warming, depletion heat transfers are also taken into account to obtain a global coupling between the different phenomena on two levels: during the winter period, the solar energy is used to heat the air in the façade [2], and

285

Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion  

E-Print Network [OSTI]

Background: Investigation of bioheat transfer problems requires the evaluation of temporal and spatial distributions of temperature. This class of problems has been traditionally addressed using the Pennes bioheat equation. ...

Martin, Gregory T

286

Space radiation-induced bystander signaling in 2D and 3D skin tissue models  

E-Print Network [OSTI]

Space radiation poses a significant hazard to astronauts on long-duration missions, and the low fluences of charged particles characteristic of this field suggest that bystander effects, the phenomenon in which a greater ...

Lumpkins, Sarah B

2012-01-01T23:59:59.000Z

287

Proximity Templates for Modeling of Skin and Proximity Effects on Packages and High Frequency Interconnect  

E-Print Network [OSTI]

. of California, Berkeley alberto@eecs.berkeley.edu Jacob White Massachusetts Instit. of Tech. white are not made or distributed for profit or commercial advantage and that copies bear this notice and the full

Daniel, Luca

288

Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora  

E-Print Network [OSTI]

Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora J. Michael Conlona,*, Agnes Sonnevendb , Carlos Davidsonc , Anni Demandtd , Thierry Jouennee-stimulated skin secretions of the Northern red-legged frog Rana aurora aurora and their primary structures

Davidson, Carlos

289

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and  

E-Print Network [OSTI]

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species J. Michael Conlon a, *, Nadia Al-Ghafari a , Laurent peptides Rana aurora Rana draytonii Skin secretions a b s t r a c t The northern red-legged frog Rana

Davidson, Carlos

290

Dosimetry for quantitative analysis of low dose ionizing radiation effects on humans in radiation therapy patients  

SciTech Connect (OSTI)

We have successfully developed a practical approach to predicting the location of skin surface dose at potential biopsy sites that receive 1 cGy and 10 cGy, respectively, in support of in vivo biologic dosimetry in humans. This represents a significant technical challenge as the sites lie on the patient surface out side the radiation fields. The PEREGRINE Monte Carlo simulation system was used to model radiation dose delivery and TLDs were used for validation on a phantom and confirmation during patient treatment. In the developmental studies the Monte Carlo simulations consistently underestimated the dose at the biopsy site by approximately 15% for a realistic treatment configuration, most likely due to lack of detail in the simulation of the linear accelerator outside the main beam line. Using a single, thickness-independent correction factor for the clinical calculations, the average of 36 measurements for the predicted 1 cGy point was 0.985 cGy (standard deviation: 0.110 cGy) despite patient breathing motion and other real world challenges. Since the 10 cGy point is situated in the region of high dose gradient at the edge of the field, patient motion had a greater effect and the six measured points averaged 5.90 cGy (standard deviation: 1.01 cGy), a difference that is equivalent to approximately a 6 mm shift on the patient's surface.

Lehmann, J; Stern, R L; Daly, T P; Schwieter, C W; Jones, G E; Arnold, M L; Hartmann-Siantar, C L; Goldberg, Z

2004-04-20T23:59:59.000Z

291

Data-driven human body morphing  

E-Print Network [OSTI]

This thesis presents an efficient and biologically informed 3D human body morphing technique through data-driven alteration of standardized 3D models. The anthropometric data is derived from a large empirical database and processed using principal...

Zhang, Xiao

2005-11-01T23:59:59.000Z

292

The Human leading the Thermal Comfort Control  

E-Print Network [OSTI]

2007 Zhang H., 2003, Human Thermal Sensation and Comfort in Transient and Non Uniform Thermal Environments; Phd Thesis Zhang H., Arens E., Huizinga C., Han T., 2010, Thermal sensations and comfort models for non-uniform and transient environments...

Zeiler, W.; Boxem, G.; Van Houten, R.; Vissers, D.; Maaijen, R.

2012-01-01T23:59:59.000Z

293

Evaluation and design of double-skin facades for office buildings in hot climates  

E-Print Network [OSTI]

efficient strategy and also the factors that affected this efficiency. The simulations were done using the building simulation software, Ener-Win. The double skin was simulated as per an approximate and simplistic calculation of the u-value, solar heat gain...

Yellamraju, Vijaya

2004-09-30T23:59:59.000Z

294

The average person sheds 40 pounds of skin during his or her lifetime. That's the  

E-Print Network [OSTI]

Q: MSU N 19 o. The average person sheds 40 pounds of skin during his or her lifetime. That whether they are facts or opinions. Fact or opinion? A fact is something that can be tested. An opinion is something that someone thinks or believes. 1. Wooly mammoths are extinct. fact opinion 2. Ear wax can

295

Have we observed the skin vibration of realistic strange stars (ReSS) ?  

E-Print Network [OSTI]

Skin vibration of ReSS and consequent resonance absorption can account for the absorption lines in the spectrum of X-ray emission from many compact stellar objects and in particular, the stars J1210$-$5226 and RXJ1856$-$3754. Observations of the X-ray spectrum of these stars is difficult to explain, if they are neutron stars.

Monika Sinha; Jishnu Dey; Mira Dey; Subharthi Ray; Siddhartha Bhowmick

2002-11-27T23:59:59.000Z

296

ON THE INFLUENCE OF THE GEOMETRY ON SKIN EFFECT IN ELECTROMAGNETISM  

E-Print Network [OSTI]

ON THE INFLUENCE OF THE GEOMETRY ON SKIN EFFECT IN ELECTROMAGNETISM GABRIEL CALOZ, MONIQUE DAUGE, ERWAN FAOU, VICTOR P´ERON ABSTRACT. We consider the equations of electromagnetism set on a domain made in electromagnetism. This effect describes the rapid decay of electromagnetic fields with depth inside a metallic

Dauge, Monique

297

CancerTherapy Skin Cooling Anthony Alleman, Duane Bywaters, David Chadburn, Drew Sparks  

E-Print Network [OSTI]

printed cooling pad with 9 ports, the final cooling pad is ABS 3D printed with a curved surface and 11 ports. ABS 3D printed CP with inner channel and 9 ports, vertical flow. 11 ports angled towards membrane ultrasound procedure to concentrate acoustic energy beneath the skin's Required heat transfer coefficients

Provancher, William

298

Original Contribution Arsenic Exposure from Drinking Water and Risk of Premalignant Skin Lesions  

E-Print Network [OSTI]

Original Contribution Arsenic Exposure from Drinking Water and Risk of Premalignant Skin Lesions, 2006. Millions of persons around the world are exposed to low doses of arsenic through drinking water from drinking water over a significant period of time. The authors evaluated dose-response relations

van Geen, Alexander

299

Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells  

SciTech Connect (OSTI)

A major problem in the treatment of type 1 diabetes mellitus is the limited availability of alternative sources of insulin-producing cells for islet transplantation. In this study, we investigated the effect of bone morphogenetic protein 4 (BMP-4) treatments of gnotobiotic porcine skin-derived stem cells (gSDSCs) on their reprogramming and subsequent differentiation into insulin-producing cells (IPCs). We isolated SDSCs from the ear skin of a gnotobiotic pig. During the proliferation period, the cells expressed stem-cell markers Oct-4, Sox-2, and CD90; nestin expression also increased significantly. The cells could differentiate into IPCs after treatments with activin-A, glucagon-like peptide-1 (GLP-1), and nicotinamide. After 15 days in the differentiation medium, controlled gSDSCs began expressing endocrine progenitor genes and proteins (Ngn3, Neuro-D, PDX-1, NKX2.2, NKX6.1, and insulin). The IPCs showed increased insulin synthesis after glucose stimulation. The results indicate that stem cells derived from the skin of gnotobiotic pigs can differentiate into IPCs under the appropriate conditions in vitro. Our three-stage induction protocol could be applied without genetic modification to source IPCs from stem cells in the skin of patients with diabetes for autologous transplantation.

Yang, Ji Hoon; Lee, Sung Ho; Heo, Young Tae [Department of Bioscience and Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)] [Department of Bioscience and Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of); Uhm, Sang Jun [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)] [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of); Lee, Hoon Taek, E-mail: htl3675@konkuk.ac.kr [Department of Animal Biotechnology, Bio-Organ Research Center, Konkuk University, Seoul 143-701 (Korea, Republic of)

2010-07-09T23:59:59.000Z

300

Lasers in Surgery and Medicine 38:137141 (2006) Thermal Responses of Ex Vivo Human Skin During Multiple  

E-Print Network [OSTI]

Departamento de Optica, Instituto Nacional de Astrofisica, Optica y Electronica, Puebla, Mexico 3 Department

Aguilar, Guillermo

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

SciTech Connect (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

302

Transport Pathways and Enhancement Mechanisms within Localized and Non-Localized Transport Regions in Skin Treated with Low-Frequency Sonophoresis and Sodium Lauryl Sulfate  

E-Print Network [OSTI]

Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not homogenous across the skin surface. Instead, ...

Polat, Baris E.

303

2114 IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 18, NO. 9, SEPTEMBER 2009 Multicamera Tracking of Articulated Human Motion  

E-Print Network [OSTI]

of humans using image sequences obtained from multiple cameras. A detailed articulated human body model. Model estimation is the process of estimating the parameters of the human body model such as the shape of Articulated Human Motion Using Shape and Motion Cues Aravind Sundaresan and Rama Chellappa, Fellow, IEEE

Sundaresan, Aravind

304

Introduction Uniform Estimates for Transmission Problems 3D Multiscaled Asymptotic Expansion Numerical Simulations Skin-Effect Description in Electromagnetism with a  

E-Print Network [OSTI]

Numerical Simulations Skin-Effect Description in Electromagnetism with a Scaled Asymptotic Expansion Gabriel.08.2009 V. P´eron Skin-Effect Description in Electromagnetism with a Scaled Asymptotic Expansion 1 / 32 and Electromagnetism MONIQUE DAUGE, ERWAN FAOU, VICTOR P ´ERON (2009) Asymptotic Behavior at High Conductivity of Skin

Paris-Sud XI, Université de

305

Cognitive Science (Humanities)  

E-Print Network [OSTI]

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

306

Modeling reaction time within a traffic simulation model  

E-Print Network [OSTI]

Human reaction time has a substantial effect on modeling of human behavior at a microscopic level. Drivers and pedestrian do not react to an event instantaneously; rather, they take time to perceive the event, process the ...

Basak, Kakali

307

Energy-dependence of skin-mode fraction in $E1$ excitations of neutron-rich nuclei  

E-Print Network [OSTI]

We have extensively investigated characters of the low-energy $E1$ strengths in $N>Z$ nuclei, by analyzing the transition densities obtained by the HF+RPA calculations with several effective interactions. Crossover behavior has been confirmed, from the skin mode at low energy to the $pn$ mode at higher energy. Decomposing the $E1$ strengths into the skin-mode, $pn$-mode and interference fractions, we show that the ratio of the skin-mode strength to the full strength may be regarded as a generic function of the excitation energy, insensitive to nuclides and effective interactions, particularly beyond Ni.

Nakada, H; Sawai, H

2015-01-01T23:59:59.000Z

308

Culture Representation in Human Reliability Analysis  

SciTech Connect (OSTI)

Understanding human-system response is critical to being able to plan and predict mission success in the modern battlespace. Commonly, human reliability analysis has been used to predict failures of human performance in complex, critical systems. However, most human reliability methods fail to take culture into account. This paper takes an easily understood state of the art human reliability analysis method and extends that method to account for the influence of culture, including acceptance of new technology, upon performance. The cultural parameters used to modify the human reliability analysis were determined from two standard industry approaches to cultural assessment: Hofstede’s (1991) cultural factors and Davis’ (1989) technology acceptance model (TAM). The result is called the Culture Adjustment Method (CAM). An example is presented that (1) reviews human reliability assessment with and without cultural attributes for a Supervisory Control and Data Acquisition (SCADA) system attack, (2) demonstrates how country specific information can be used to increase the realism of HRA modeling, and (3) discusses the differences in human error probability estimates arising from cultural differences.

David Gertman; Julie Marble; Steven Novack

2006-12-01T23:59:59.000Z

309

Influence of the single-particle structure on the nuclear surface and the neutron skin  

E-Print Network [OSTI]

We analyze the influence of the single-particle structure on the neutron density distribution and the neutron skin in Ca, Ni, Zr, Sn, and Pb isotopes. The nucleon density distributions are calculated in the Hartree-Fock+BCS approach with the SLy4 Skyrme force. A close correlation is found between the quantum numbers of the valence neutrons and the changes in the position and the diffuseness of the nuclear surface, which in turn affect the neutron skin thickness. Neutrons in the valence orbitals with low principal quantum number and high angular momentum mainly displace the position of the neutron surface outwards, while neutrons with high principal quantum number and low angular momentum basically increase the diffuseness of the neutron surface. The impact of the valence shell neutrons on the tail of the neutron density distribution is discussed.

M. Warda; M. Centelles; X. Vinas; X. Roca-Maza

2014-04-03T23:59:59.000Z

310

An evaluation of floor surfaces on the basis of skin temperature during constrained standing  

E-Print Network [OSTI]

popliteal fossa (popliteal region), and the medial side of abductor hallucis on the non-load bearing region of the foot (near the intersection of the top of the arch and the instep) or the foot region. All thermistors were located on the left leg... between an average ending temperature and an average start-up temperature. The foot skin temperature region was the only temperature region to indicate statistically significant results between the floor surfaces. The other two lower leg temperature...

Monford, Leo Gabriel

1995-01-01T23:59:59.000Z

311

The SACADA database for human reliability and human performance  

SciTech Connect (OSTI)

Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

2014-05-01T23:59:59.000Z

312

Effect of dietary polyunsaturated fatty acid and related nutrients on plasma lipids, and skin and hair coat condition in canines  

E-Print Network [OSTI]

phospholipid fatty acids were determined at each collection period. Serum zinc concentrations were analyzed on wk 12, 14, and 24. The hypothesis was that a diet containing increased LA, ALA, and zinc concentrations (diet C) would show improvements of skin...

Hester, Shaleah Lynnae

2004-11-15T23:59:59.000Z

313

Quantitative studies of rattlesnake (Crotalus atrox: venom, venom fractions, and rabbit antivenom: Lethality, skin sensitivity, and antibody characterization.  

E-Print Network [OSTI]

QUANTITATIVE STUDIES OF RATTLESNAKE (CROTALUS ATROX) VENOM, VENOM FRACTIONS, AND RABBIT ANTIVENOM: LETHALITY, SKIN SENSITIVITY, AND ANTIBODY CHARACTERIZATION A Thesis By RICHARD PATTON BRADBURY Submitted to the Graduate College of the Texas...: LETHALITY, SKIN SENSITIVITY, AND ANTIBODY CHARACTERIZATION A Thesis By RICHARD PATTON BRADBURY Approved as to style and content by: (Chairman of Committee) Q(cf f. 4&a (Member) (Coordinator, Space Medicine (Member) Program and Member) August 1967...

Bradbury, Richard Patton

2012-06-07T23:59:59.000Z

314

Human Resources Assistant  

Broader source: Energy.gov [DOE]

This position is located in the Headquarters (HQ) Operations Division of the Office of the Chief Human Capital Officer in Washington, DC. The Division provides a full range of human capital...

315

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

316

Liquid RF Antennas, Electronics and Sensors: A Modeling Challenge Anya Traille and Manos M. Tentzeris  

E-Print Network [OSTI]

of metal [3]. While metallic antennas are quite effective in the air, they exhibit a sharp dielectric], while inkjet-printable batteries require the deposition of semi-liquid conductive gels. Plus, many efficiency. A conventional metal antenna placed flush into human skin will induce a surface wave within

Tentzeris, Manos

317

Human Research ProgramHuman Research Program Human System Risk in Exploration and  

E-Print Network [OSTI]

Human System Risks in Exploration Missions 21SEP10 2HRP Risk Process ­ D.Grounds Presentation contentsHuman Research ProgramHuman Research Program Human System Risk in Exploration and the Human Research Program 21SEP10 1HRP Risk Process ­ D Grounds #12;Human Research ProgramHuman Research Program

Waliser, Duane E.

318

Statistical models for analyzing human genetic variation  

E-Print Network [OSTI]

Atlas (termed CSA-100). BCMET refers to the Evolutionary TraceAtlas (termed CSA-100). BCMET refers to the Evolutionary Trace

Sankararaman, Sriram

2010-01-01T23:59:59.000Z

319

Jones, G., & Ritter, F. E. (2000). Over-estimating cognition time: The benefits of using a task simulation. In Simulating Human Agents, American Association for Artificial Intelligence Fall  

E-Print Network [OSTI]

architectures began incorporating simulation envir of human behavior are most worth capturing in a human modeling architectures? This paper presents a case, the model of the task may have been developed in an architecture or modelling environment for which

Ritter, Frank

320

Dose profiles through the dermis for on and off-skin hot particle exposures  

E-Print Network [OSTI]

compared to gamma-rays. Gamma-rays are monoenergetic photons with energies ranging from a few keV to several MeV. Unlike beta particles, gamma-rays are indirectly ionizing radiation. Because a gamma-ray is uncharged, it undergoes no direct ionization... detailed data on dose profiles This thesis follows the format of Radiation Protection Dosimetry. through the dermis from fuel fragments or from mixed beta-gamma activation products. The effects of beta-emitting hot particles suspended above skin without...

Shaw, Kimberly Rochelle

1993-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Constraining the symmetry energy from the neutron skin thickness of Tin isotopes  

E-Print Network [OSTI]

We show in the Skyrme-Hartree-Fock approach that unambiguous correlations exist between observables of finite nuclei and nuclear matter properties. Using this correlation analysis to existing data on the neutron skin thickness of Sn isotopes, we find important constraints on the value E_{sym}(rho_0) and density slope L of the nuclear symmetry energy at saturation density. Combining these constraints with those from recent analyses of isospin diffusion and double neutron/proton ratio in heavy ion collisions leads to a value of L=58\\pm 18 MeV approximately independent of E_{sym}(\\rho_0).

Lie-Wen Chen; Che Ming Ko; Jun Xu; Bao-An Li

2011-03-24T23:59:59.000Z

322

E-Print Network 3.0 - absorbed fraction internal irradiation...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Fission and Nuclear Technologies 56 Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin model Summary: partial irradiation with...

323

Wire and column modeling  

E-Print Network [OSTI]

The goal of this thesis is to introduce new methods to create intricate perforated shapes in a computing environment. Modeling shapes with a large number of holes and handles, while requiring minimal human interaction, is an unsolved research...

Mandal, Esan

2004-09-30T23:59:59.000Z

324

Modeling and Optimal Regulation of Erythropoiesis Subject to Benzene Intoxication  

E-Print Network [OSTI]

humans and laboratory animals [11, 16]. Increased incidence of acute myelogenous leukemia in humans obtained in vitro [5, 6]. Since in vitro metabolic parameters are also available for humans, the model could then be extrapolated to humans for risk assessment. Since benzene is a known human leukemogen

325

Constraints on neutron skin thickness in 208Pb and density-dependent symmetry energy  

E-Print Network [OSTI]

Accurate knowledge about the neutron skin thickness $\\Delta R_{np}$ in $^{208}$Pb has far-reaching implications for different communities of nuclear physics and astrophysics. Yet, the novel Lead Radius Experiment (PREX) did not yield stringent constraint on the $\\Delta R_{np}$ recently. We employ a more practicable strategy currently to probe the neutron skin thickness of $^{208}$Pb based on a high linear correlation between the $\\Delta R_{np}$ and $J-a_{\\text{sym}}$, where $J$ and $a_{\\text{sym}}$ are the symmetry energy (coefficient) of nuclear matter at saturation density and of $^{208}$Pb. An accurate $J-a_{\\text{sym}}$ thus places a strong constraint on the $\\Delta R_{np}$. Compared with the parity-violating asymmetry $A_{\\text{PV}}$ in the PREX, the reliably experimental information on the $J-a_{\\text{sym}}$ is much more easily available attributed to a wealth of measured data on nuclear masses and on decay energies. The density dependence of the symmetry energy is also well constrained with the $J-a_{\\...

Dong, Jianmin; Gu, Jianzhong

2015-01-01T23:59:59.000Z

326

On the evaluation of human error probabilities for post-initiating events  

E-Print Network [OSTI]

Quantification of human error probabilities (HEPs) for the purpose of human reliability assessment (HRA) is very complex. Because of this complexity, the state of the art includes a variety of HRA models, each with its own ...

Presley, Mary R

2006-01-01T23:59:59.000Z

327

Skin cancer in albinos at the University of Calabar Teaching Hospital, Calabar, Nigeria  

E-Print Network [OSTI]

of the human P gene in tyrosinase positive oculocutaneousJenkins T, Ramsay M. The tyrosinase positive oculocutaneousrecessive forms involves the tyrosinase gene (OCA1), whereas

Asuquo, M E; Otei, O O; Omotoso, J; Bassey, E E

2010-01-01T23:59:59.000Z

328

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

2000-05-15T23:59:59.000Z

329

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

2007-12-20T23:59:59.000Z

330

STUDENT EMPLOYMENT HUMAN RESOURCES  

E-Print Network [OSTI]

STUDENT EMPLOYMENT HUMAN RESOURCES GUIDELINE Human Resources | One Washington Square | San José, CA 95192-0046 | 408-924-2250 408-924-2284 (fax) SUBJECT: STUDENT EMPLOYMENT DATE: March 2007 I. PURPOSE / DESCRIPTION Student employees are defined as matriculated students that work part-time in any

Gleixner, Stacy

331

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

332

Model’ or ‘tool’? New definitions for translational research  

E-Print Network [OSTI]

The term ‘model’ often describes non-human biological systems that are used to obtain a better understanding of human disorders. According to the most stringent definition, an animal ‘model’ would display exactly the same ...

Sive, Hazel

333

Modeling active electrolocation in weakly electric fish Habib Ammari  

E-Print Network [OSTI]

Modeling active electrolocation in weakly electric fish Habib Ammari Thomas Boulier Josselin in weakly electric fishes. We first investigate the forward complex conductivity problem and derive the approx- imate boundary conditions on the skin of the fish. Then we provide a dipole approximation

Garnier, Josselin

334

Residential agents and land use change modelling   

E-Print Network [OSTI]

Urbanisation is driven by the complex interactions of many physical and human factors where human actions and decisions, individually and collectively, ultimately shape the patterns of urban landscapes. Agentbased modelling ...

Fontaine, Corentin M.

2010-01-01T23:59:59.000Z

335

Biosphere Model Report  

SciTech Connect (OSTI)

The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

D.W. Wu; A.J. Smith

2004-11-08T23:59:59.000Z

336

ISSUE 1 | SPRING 2014 BRINGING CUTTING-EDGE SCIENCE INTO THE CLASSROOM UNDER YOUR SKIN  

E-Print Network [OSTI]

more resources at www. wellcome.ac.uk/bigpicture/ proteins. inSide PROBING PROTEINS A numerical look to www.wellcome.ac.uk/bigpicture/ proteins for more teaching resources, including extra articles, useful. Mitochondrion Human egg Globular protein Uk argentina Bangladesh in human proteins are essential

Rambaut, Andrew

337

Animating Human Athletics Jessica K. Hodgins Wayne L. Wooten  

E-Print Network [OSTI]

Animating Human Athletics Jessica K. Hodgins Wayne L. Wooten David C. Brogan James F. O animate these behaviors using control algorithms that cause a physically realistic model to perform and biomechanical data. Key Words and Phrases: computer animation, human motion, motion control, dynamic simulation

Brogan, David

338

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources  

E-Print Network [OSTI]

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources VOLUNTARY WORKLOAD/or Spring ____ Quarter(s) Funding Source: ________________________________________ (Salary adjustments

California at Santa Cruz, University of

339

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada  

E-Print Network [OSTI]

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada 1) Permits be obtained from the Public Health Agency Canada (PHAC) to facilitate customs clearance. 2) If a permit

340

Division of Human Resources Human Resources / Attendance and Leave Philosophy  

E-Print Network [OSTI]

Division of Human Resources PHILOSOPHY Human Resources / Attendance and Leave Philosophy Form Leave Act (FMLA). USF augments these provisions with local processes and philosophies and, in some cases

Meyers, Steven D.

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Proc. 3rd International Conference on Networked Sensing Systems (INSS 2006), pp. 55-60, Rosemont, Illinois (USA), May, 2006. A Whole Body Artificial Skin  

E-Print Network [OSTI]

are required to be more cautious about surrounding environments than robots in industrial factories because a tactile sensor skin as one of applications of the system. In this application, the cells are not only within its sensing area. The resulting robot skin is soft, stretchable, and able to cover a large area

Shinoda, Hiroyuki

342

Associate Vice President Human Resources  

E-Print Network [OSTI]

Associate Vice President Human Resources Enjoy Athens! Great schools Affordable housing Eclectic Vice President for Human Resources. This position reports directly to the Vice President for Finance and Administration and provides leadership for the University's human resources programs and services

Arnold, Jonathan

343

Human Resources Simon Fraser University  

E-Print Network [OSTI]

Human Resources Simon Fraser University Administrative and Professional Staff Job Description A. Identification Position Number: 31482 Position Title: Administrative Assistant (Human Resources Liaison) Name guidance, direction, coordination and effective management and implementation of SFU's Human Resources

Kavanagh, Karen L.

344

The human genome project  

SciTech Connect (OSTI)

The Human Genome Project will obtain high-resolution genetic and physical maps of each human chromosome and, somewhat later, of the complete nucleotide sequence of the deoxyribonucleic acid (DNA) in a human cell. The talk will begin with an extended introduction to explain the Project to nonbiologists and to show that map construction and sequence determination require extensive computation in order to determine the correct order of the mapped entities and to provide estimates of uncertainty. Computational analysis of the sequence data will become an increasingly important part of the project, and some computational challenges are described. 5 refs.

Bell, G.I.

1991-06-01T23:59:59.000Z

345

Effect of temperature on the effective mass and the neutron skin of nuclei  

E-Print Network [OSTI]

We study the finite temperature Hartree-Fock-BCS approximation for selected stable Sn nuclei with zero-range Skyrme forces. Hartree Fock BCS approximation allows for a straightforward interpretation of the results since it involves u and v's which are not matrices as in HFB. Pairing transitions from superfluid to the normal state are studied with respect to the temperature. The temperature dependence of the nuclear radii and neutron skin are also analyzed. An increase of proton and neutron radii is obtained in neutron rich nuclei especially above the critical temperature. Using different Skyrme energy functionals, it is found that the correlation between the effective mass in symmetric nuclear matter and the critical temperature depends on the pairing prescription. The temperature dependence of the nucleon effective mass is also investigated, showing that proton and neutron effective masses display different behavior below and above the critical temperature, due to the small temperature dependence of the density.

E. Yüksel; E. Khan; K. Bozkurt; G. Colò

2014-10-31T23:59:59.000Z

346

The neutron skin in neutron-rich nuclei at Jefferson Lab  

SciTech Connect (OSTI)

The Jefferson Lab program to measure the symmetry energy of neutron-rich nuclear matter, using precision electroweak methods, is progressing well. The initial measurement by the PREX experiment, leading to a 2-sigma determination of the 'neutron skin' in {sup 208}Pb, has been published. Design and preparation for a further, more-precise measurement on {sup 208}Pb is progressing well and there is general acceptance of the great advantage to a further measurement on {sup 48}Ca. The surprising ancillary result that the beam-normal single-spin asymmetry for {sup 208}Pb is consistent with zero is also now in the literature. This paper will discuss the current experimental situation of the program.

Dalton, Mark M. [University of Virginia (United States)

2013-11-07T23:59:59.000Z

347

Neutron-skin thickness from the study of the anti-analog giant dipole resonance  

SciTech Connect (OSTI)

The {gamma}-decay of the anti-analog of the giant dipole resonance (AGDR) to the isobaric analog state has been measured following the p({sup 124}Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent relativistic random-phase approximation (RPA) and turned out to be very sensitive to the neutronskin thickness ({Delta}R{sub pn}). By comparing the theoretical results with the measured one, the {Delta}R{sub pn} value for {sup 124}Sn was deduced to be 0.21 {+-} 0.07 fm, which agrees well with the previous results. The present method offers new possibilities for measuring the neutron-skin thicknesses of very exotic isotopes.

Krasznahorkay, A.; Stuhl, L.; Csatlos, M.; Algora, A. [Inst. of Nucl. Res. of the Hungarian Acad. of Sci. (ATOMKI), H-4001 Debrecen, P.O. Box 51 (Hungary); Physics Department, Faculty of Science, University of Zagreb (Croatia); Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); and others

2012-10-20T23:59:59.000Z

348

Method of forming a continuous polymeric skin on a cellular foam material  

DOE Patents [OSTI]

Hydrophobic cellular material is coated with a thin hydrophilic polymer skin which stretches tightly over the outer surface of the foam but which does not fill the cells of the foam, thus resulting in a polymer-coated foam structure having a smoothness which was not possible in the prior art. In particular, when the hydrophobic cellular material is a specially chosen hydrophobic polymer foam and is formed into arbitrarily chosen shapes prior to the coating with hydrophilic polymer, inertial confinement fusion (ICF) targets of arbitrary shapes can be produced by subsequently coating the shapes with metal or with any other suitable material. New articles of manufacture are produced, including improved ICF targets, improved integrated circuits, and improved solar reflectors and solar collectors. In the coating method, the cell size of the hydrophobic cellular material, the viscosity of the polymer solution used to coat, and the surface tensin of the polymer solution used to coat are all very important to the coating.

Duchane, David V. (Los Alamos, NM); Barthell, Barry L. (Los Alamos, NM)

1985-01-01T23:59:59.000Z

349

Combining human and machine intelligence for making predictions  

E-Print Network [OSTI]

An extensive literature in psychology, economics, statistics, operations research and management science has dealt with comparing forecasts based on human-expert judgment vs. (statistical) models in a variety of scenarios, ...

Nagar, Yiftach

2013-01-01T23:59:59.000Z

350

Transformation of human melanocytes and mechanisms of melanoma metastasis  

E-Print Network [OSTI]

While a fundamental feature of human melanoma is its tendency to metastasize to numerous organs throughout the body, very few animal models recapitulate this essential aspect of the disease. In the work described, it is ...

Gupta, Piyush B

2006-01-01T23:59:59.000Z

351

Landau damping and anomalous skin effect in low-pressure gas discharges: Self-consistent treatment of collisionless heatinga...  

E-Print Network [OSTI]

for calculation of the non-Maxwellian EEDF. This system was applied to the calculation of collisionless heating electric field anomalous skin effect . Also for inhomogeneous electric fields another mechanism of heating density profile and a Maxwellian EEDF. In the present study a self-consistent system of equations

Kaganovich, Igor

352

322 IEEE JOURNAL OF QUANTUM ELECTRONICS, VOL. 37, NO. 3, MARCH 2001 Mechanism Study of Porcine Skin Ablation  

E-Print Network [OSTI]

, biomedical applica- tions of optical radiation, biological tissues, laser ablation, neodymium:YAG lasers identified the Na spectral line at 589 nm in the secondary radiation from the ablated skin sample, spectral analysis. I. INTRODUCTION IN THE progression of less-damaging surgical laser proce- dures

353

Proper Setup of HVAC System in Conjunction with Sound Building 'Skin' Design for Alleviation of IAQ and Energy Performance Problems  

E-Print Network [OSTI]

climates, not only because of the loss of energy, but also because of damage that can result to insulation, drywall, and structure in addition to promotion of mold and mildew growth. Proper setup of the HVAC system, in conjunction with sound building “skin...

Rosenberg, M.

2006-01-01T23:59:59.000Z

354

Surgical technique, using skin, for repair of simultaneously ruptured anterior cruciate and medial collateral ligaments of the canine femorotibial articulation  

E-Print Network [OSTI]

Agricultural and Mechanical College of Texan In Partial Fulfillnent of the !Iequireaents for the Degree Meeter of Science in Veterinary Medicine and Surgery by Janie Neal Chaetain January 1&359 SURGICAL TECHNI((UE ~ USIN'G SKIN ~ FOR REPAIR...

Chastain, Jamie Neal

1959-01-01T23:59:59.000Z

355

Viscoelastic Analysis of Sandwich Beams Having Aluminum and Fiber-reinforced Polymer Skins with a Polystyrene Foam Core  

E-Print Network [OSTI]

Sandwich beams are composite systems having high stiffness-to-weight and strength-to-weight ratios and are used as light weight load bearing components. The use of thin, strong skin sheets adhered to thicker, lightweight core materials has allowed...

Roberts-Tompkins, Altramese L.

2010-07-14T23:59:59.000Z

356

Human Reliability | ornl.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Reliability SHARE Human Reliability The Structured Trusted Employee Program (STEP) Evaluation is an example of a method for identifying, assessing, and retaining reliable and...

357

automatic model based: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

still far worse than that of humans. This is partly caused by the use of poor statistical models. In a general statistical pattern classification task, the probabilistic models...

358

Human Reliability Program Overview  

SciTech Connect (OSTI)

This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

Bodin, Michael

2012-09-25T23:59:59.000Z

359

KRFTWRK – Global Human Electricity  

E-Print Network [OSTI]

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

360

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

2007-12-20T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

2000-05-15T23:59:59.000Z

362

Human Resource Management Delegation  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

1996-06-28T23:59:59.000Z

363

TEMPORARY SUPPORT HUMAN RESOURCES  

E-Print Network [OSTI]

TEMPORARY SUPPORT HUMAN RESOURCES GUIDELINE Workforce Planning | One Washington Square | San José of the Request for Temporary Support, Workforce Planning will make a determination of the type of temporary

Su, Xiao

364

Combining Modeling and Gaming for Predictive Analytics  

SciTech Connect (OSTI)

Many of our most significant challenges involve people. While human behavior has long been studied, there are recent advances in computational modeling of human behavior. With advances in computational capabilities come increases in the volume and complexity of data that humans must understand in order to make sense of and capitalize on these modeling advances. Ultimately, models represent an encapsulation of human knowledge. One inherent challenge in modeling is efficient and accurate transfer of knowledge from humans to models, and subsequent retrieval. The simulated real-world environment of games presents one avenue for these knowledge transfers. In this paper we describe our approach of combining modeling and gaming disciplines to develop predictive capabilities, using formal models to inform game development, and using games to provide data for modeling.

Riensche, Roderick M.; Whitney, Paul D.

2012-08-22T23:59:59.000Z

365

Vision application of human robot interaction: Development of a ping pong playing robotic arm.  

E-Print Network [OSTI]

?? Robotics is a science that is implemented parallel to human behavior. This work describes and implements techniques to mathematically model the game of ping… (more)

Modi, Kalpesh Prakash

2005-01-01T23:59:59.000Z

366

E-Print Network 3.0 - antimicrobial peptide human Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Antimicrobial Properties by a Rational Prediction Model Summary: -Reyes SO, Teran LM (2010) Antimicrobial peptides: general overview and clinical implications in human......

367

E-Print Network 3.0 - anti-fya seraclone human Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

presented. Sphere-based geometric models... are used for the human and robot due to the efficiency of the distance computation. The collision avoidance Source: Bone, Gary -...

368

E-Print Network 3.0 - atm radiosensitizes human Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 3 Journal of Theoretical Biology 230 (2004) 120 A four-dimensional simulation model of tumour response to Summary: The intrinsic radiosensitivity of human tumour...

369

Time, Humans and Societal Challenges  

E-Print Network [OSTI]

,000 (human development) Since 1850 (industrial revolution Since 1950 (population explosion) Sustainable

370

Planet-scale Human Mobility Measurement  

E-Print Network [OSTI]

Research into, and design and construction of mobile systems and algorithms requires access to large-scale mobility data. Unfortunately, the wireless and mobile research community lacks such data. For instance, the largest available human contact traces contain only 100 nodes with very sparse connectivity, limited by experimental logistics. In this paper we pose a challenge to the community: how can we collect mobility data from billions of human participants? We re-assert the importance of large-scale datasets in communication network design, and claim that this could impact fundamental studies in other academic disciplines. In effect, we argue that planet-scale mobility measurements can help to save the world. For example, through understanding large-scale human mobility, we can track and model and contain the spread of epidemics of various kinds.

Pan Hui; Richard Mortier; Tristan Henderson; Jon Crowcroft

2009-09-18T23:59:59.000Z

371

Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic  

SciTech Connect (OSTI)

Chronic arsenic (As) exposure affects the endothelial system causing several diseases. Big endothelin-1 (Big ET-1), the biological precursor of endothelin-1 (ET-1) is a more accurate indicator of the degree of activation of the endothelial system. Effect of As exposure on the plasma Big ET-1 levels and its physiological implications have not yet been documented. We evaluated plasma Big ET-1 levels and their relation to hypertension and skin lesions in As exposed individuals in Bangladesh. A total of 304 study subjects from the As-endemic and non-endemic areas in Bangladesh were recruited for this study. As concentrations in water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The plasma Big ET-1 levels were measured using a one-step sandwich enzyme immunoassay kit. Significant increase in Big ET-1 levels were observed with the increasing concentrations of As in drinking water, hair and nails. Further, before and after adjusting with different covariates, plasma Big ET-1 levels were found to be significantly associated with the water, hair and nail As concentrations of the study subjects. Big ET-1 levels were also higher in the higher exposure groups compared to the lowest (reference) group. Interestingly, we observed that Big ET-1 levels were significantly higher in the hypertensive and skin lesion groups compared to the normotensive and without skin lesion counterpart, respectively of the study subjects in As-endemic areas. Thus, this study demonstrated a novel dose–response relationship between As exposure and plasma Big ET-1 levels indicating the possible involvement of plasma Big ET-1 levels in As-induced hypertension and skin lesions. -- Highlights: ? Plasma Big ET-1 is an indicator of endothelial damage. ? Plasma Big ET-1 level increases dose-dependently in arsenic exposed individuals. ? Study subjects in arsenic-endemic areas with hypertension have elevated Big ET-1 levels. ? Study subjects with arsenic-induced skin lesions show elevated plasma Big ET-1 levels. ? Arsenic-induced hypertension and skin lesions may be linked to plasma Big ET-1 levels.

Hossain, Ekhtear; Islam, Khairul; Yeasmin, Fouzia [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh); Karim, Md. Rezaul [Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003 (Bangladesh)] [Department of Applied Nutrition and Food Technology, Islamic University, Kushtia-7003 (Bangladesh); Rahman, Mashiur; Agarwal, Smita; Hossain, Shakhawoat; Aziz, Abdul; Al Mamun, Abdullah; Sheikh, Afzal; Haque, Abedul; Hossain, M. Tofazzal [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh); Hossain, Mostaque [Department of Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka (Bangladesh)] [Department of Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka (Bangladesh); Haris, Parvez I. [Faculty of Health and Life Sciences, De Montfort University, Leicester, LE1 9BH (United Kingdom)] [Faculty of Health and Life Sciences, De Montfort University, Leicester, LE1 9BH (United Kingdom); Ikemura, Noriaki; Inoue, Kiyoshi; Miyataka, Hideki; Himeno, Seiichiro [Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514 (Japan)] [Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514 (Japan); Hossain, Khaled, E-mail: khossain69@yahoo.com [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)] [Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi-6205 (Bangladesh)

2012-03-01T23:59:59.000Z

372

CANDU human performance analysis  

SciTech Connect (OSTI)

An evaluation of human performance is presented in this paper in the context of the operational safety management system. To focus on problems, an experience review program has been developed to establish trends, demonstrate the degree of compliance with standards, and determine the causes of poor performance. The primary method by which the experience review takes place is significant event reporting (SER). A significant event is an incident that causes an undesirable effect on safety, product quality, environmental protection, or product cost. In spite of advanced technology and the degree of automation of the Canada deuterium uranium (CANDU) design, mistakes and malfunctions to occur. Considerable effort has been made to prevent or reduce the incidence of error. The Institute of Nuclear Power Operations developed a system to analyze human error, called the Human Performance Evaluation System (HPES). To encourage an open exchange of information, the system is anonymous and nonpunitive. All data gathered during HPES evaluations are kept confidential.

Walker, I.

1987-01-01T23:59:59.000Z

373

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

374

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

375

IEEE JOURNAL OF QUANTUM ELECTRONICS, VOL. 40, NO. 1, JANUARY 2004 69 Modeling of Skin Tissue Ablation by Nanosecond  

E-Print Network [OSTI]

results. Index Terms--Biological tissues, biomedical applications of optical radiation, laser ablation Ablation by Nanosecond Pulses From Ultraviolet to Near-Infrared and Comparison With Experimental Results in a broad optical spectrum is of fundamental importance to the understanding of laser-tissue interaction

376

Learning Nonparametric Models for Probabilistic Imitation  

E-Print Network [OSTI]

in humans and robots. A critical requirement for learning by imi- tation is the ability to handle- chanical model of the human arm and a 25-degrees-of-freedom humanoid robot. We demonstrate by the humanoid robot. 1 Introduction A fundamental and versatile mechanism for learning in humans is imitation

Rao, Rajesh

377

Integrated Assessment Modeling  

SciTech Connect (OSTI)

This paper discusses the role of Integrated Assessment models (IAMs) in climate change research. IAMs are an interdisciplinary research platform, which constitutes a consistent scientific framework in which the large-scale interactions between human and natural Earth systems can be examined. In so doing, IAMs provide insights that would otherwise be unavailable from traditional single-discipline research. By providing a broader view of the issue, IAMs constitute an important tool for decision support. IAMs are also a home of human Earth system research and provide natural Earth system scientists information about the nature of human intervention in global biogeophysical and geochemical processes.

Edmonds, James A.; Calvin, Katherine V.; Clarke, Leon E.; Janetos, Anthony C.; Kim, Son H.; Wise, Marshall A.; McJeon, Haewon C.

2012-10-31T23:59:59.000Z

378

Magnetic reconnection on the ion-skin-depth scale in the dusty magnetotail of a comet  

SciTech Connect (OSTI)

Resistive magnetic reconnection is studied in a dusty plasma configuration without a guide magnetic field, typical for cometary tails. For a high-{beta} plasma ({beta}{approx}1) consisting of electrons, ions, and immobile dust grains that constitute a neutralizing background, a two-fluid description is used to study electromagnetic perturbations with the frequency below the ion gyrofrequency, propagating at an arbitrary angle relative to the background magnetic field and including the effects of the Hall current. The perturbations consist of both the compressional and torsional components of the magnetic field, as well as of the acoustic perturbations and the electrostatic potential. The symmetry breaking between electrons and ions, introduced by the presence of dust grains, gives rise to an E-vectorxB-vector current in the unperturbed state which can support an antiparallel magnetic field configuration even in a cold plasma. In the perturbed state, the emergence of a new electromagnetic mode in a dusty plasma, which is evanescent below the Rao cutoff frequency and has the characteristic wavelength comparable to the ion skin depth, enables the reconnection at short spatial scales. The growth rate of the tearing instability is evaluated analytically.

Jovanovic, D.; Shukla, P.K.; Morfill, G. [Institute of Physics, P.O. Box 57, 11001 Belgrade (Serbia and Montenegro); Institut fuer Theoretische Physik IV, Ruhr-Universitaet Bochum, D-44780 Bochum (Germany); Max-Planck-Institut fuer extraterrestrische Physik, D-85740 Garching (Germany)

2005-04-15T23:59:59.000Z

379

Optical properties of metals: Infrared emissivity in the anomalous skin effect spectral region  

SciTech Connect (OSTI)

When the penetration depth of an electromagnetic wave in a metal is similar to the mean free path of the conduction electrons, the Drude classical theory is no longer satisfied and the skin effect becomes anomalous. Physical parameters of this theory for twelve metals were calculated and analyzed. The theory predicts an emissivity peak ?{sub peak} at room temperature in the mid-infrared for smooth surface metals that moves towards larger wavelengths as temperature decreases. Furthermore, the theory states that ?{sub peak} increases with the emission angle but its position, ?{sub peak}, is constant. Copper directional emissivity measurements as well as emissivity obtained using optical constants data confirm the predictions of the theory. Considering the relationship between the specularity parameter p and the sample roughness, it is concluded that p is not the simple parameter it is usually assumed to be. Quantitative comparison between experimental data and theoretical predictions shows that the specularity parameter can be equal to one for roughness values larger than those predicted. An exhaustive analysis of the experimental optical parameters shows signs of a reflectance broad peak in Cu, Al, Au, and Mo around the wavelength predicted by the theory for p?=?1.

Echániz, T. [Departamento de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, UPV/EHU, Sarriena s/n, Leioa 48940 (Spain); Pérez-Sáez, R. B., E-mail: raul.perez@ehu.es; Tello, M. J. [Departamento de Física de la Materia Condensada, Facultad de Ciencia y Tecnología, UPV/EHU, Sarriena s/n, Leioa 48940 (Spain); Instituto de Síntesis y Estudio de Materiales, Universidad del País Vasco, Apdo. 644, Bilbao 48080 (Spain)

2014-09-07T23:59:59.000Z

380

Coordination-resolved local bond contraction and electron binding-energy entrapment of Si atomic clusters and solid skins  

SciTech Connect (OSTI)

Consistency between x-ray photoelectron spectroscopy measurements and density-function theory calculations confirms our bond order-length-strength notation-incorporated tight-binding theory predictions on the quantum entrapment of Si solid skin and atomic clusters. It has been revealed that bond-order deficiency shortens and strengthens the Si-Si bond, which results in the local densification and quantum entrapment of the core and valence electrons. Unifying Si clusters and Si(001) and (111) skins, this mechanism has led to quantification of the 2p binding energy of 96.089?eV for an isolated Si atom, and their bulk shifts of 2.461?eV. Findings evidence the significance of atomic undercoordination that is of great importance to device performance.

Bo, Maolin; Huang, Yongli; Zhang, Ting [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); Wang, Yan, E-mail: ywang8@hnust.edu.cn, E-mail: ecqsun@ntu.edu.sg [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); School of Information and Electronic Engineering, Hunan University of Science and Technology, Hunan 411201 (China); Zhang, Xi [School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 (Singapore); Li, Can [Center for Coordination Bond Engineering, School of Materials Science and Engineering, China Jiliang University, Hangzhou 330018 (China); Sun, Chang Q., E-mail: ywang8@hnust.edu.cn, E-mail: ecqsun@ntu.edu.sg [Key Laboratory of Low-Dimensional Materials and Application Technologies, Xiangtan University, Hunan 411105 (China); School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 (Singapore); Center for Coordination Bond Engineering, School of Materials Science and Engineering, China Jiliang University, Hangzhou 330018 (China)

2014-04-14T23:59:59.000Z

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Human Processing (Position Paper)  

E-Print Network [OSTI]

and describe remaining challenges in the area (Section 6). 2. MOTIVATING EXAMPLE "Priam," the editor below, we explain how Priam might go about accomplishing this task. Figure 1: Basic Buyer human. The programmer (Priam) writes a normal program. 2. That program can, in the course of execution, create HTML

Chang, Edward Y.

382

transforming human health  

E-Print Network [OSTI]

transforming human health AnnUAl REpoRt 2011­2012 #12;#12;how we're changing medical research 1 are transforming health. He proposed an entirely new theory for developing drugs to treat diseases that have malaria and solid tumors such as lung and breast cancers are in development. #12;A TrAnsformATive educ

Kenny, Paraic

383

Climate and Environmental Sciences Division Strategic Plan Water is a key component of the earth and human  

E-Print Network [OSTI]

, and subsurface processes, as well as climate and earth system modeling and integrated assessment modeling and plan the development of next- generation human-earth system models for improving long-term predictions

Wood, Robert

384

Human-computer interaction task learning: an empirical investigation of interface quality  

E-Print Network [OSTI]

This research examines learnability measures derived from the all-or-none stochastic learning model. The all-or-none model represents the paired-associate learning that occurs during the initial learning of human-computer interaction (HCI) tasks...

Packebush, Sherrill Janine

1993-01-01T23:59:59.000Z

385

Sampling in human cognition  

E-Print Network [OSTI]

Bayesian Decision Theory describes optimal methods for combining sparse, noisy data with prior knowledge to build models of an uncertain world and to use those models to plan actions and make novel decisions. Bayesian ...

Vul, Edward

2010-01-01T23:59:59.000Z

386

Locoregional Outcomes of Inflammatory Breast Cancer Patients Treated With Standard Fractionation Radiation and Daily Skin Bolus in the Taxane Era  

SciTech Connect (OSTI)

Purpose: To assess locoregional outcomes of inflammatory breast cancer (IBC) patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy (CMT). Methods and Materials: We retrospectively reviewed the charts of 107 patients diagnosed with IBC between January 1995 and March 2006 who presented to our department for adjuvant radiation therapy (RT). Results: All patients received chemotherapy (95% anthracycline and 95% taxane), modified radical mastectomy, and RT to the chest wall and regional lymphatics using standard fractionation to 50 Gy and daily skin bolus. The RT to the chest wall was delivered via electrons (55%) or photons (45%) in daily fractions of 180 cGy (73%) or 200 cGy (27%). Scar boost was performed in 11%. A majority (84%) of patients completed the prescribed treatment. Median follow-up was 47 months (range, 10-134 months). Locoregional control (LRC) at 3 years and 5 years was 90% and 87%, respectively. Distant metastases-free survival (DMFS) at 3 years and 5 years was 61% and 47%, respectively. Conclusions: Excellent locoregional control was observed in this population of IBC patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy. Distant metastases-free survival remains a significant therapeutic challenge.

Damast, Shari, E-mail: damasts@mskcc.or [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Ho, Alice Y. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Montgomery, Leslie [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Fornier, Monica N. [Department of Breast Cancer Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Ishill, Nicole; Elkin, Elena [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Beal, Kathryn; McCormick, Beryl [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2010-07-15T23:59:59.000Z

387

Human sciences The human sciences database contains approximately 254 academic  

E-Print Network [OSTI]

Human sciences The human sciences database contains approximately 254 academic journals and statistical reports on the following subjects: (comparative literature, theology, history and geography, education, psychology, arts, languages and Library Science) Social sciences The social sciences database

388

Human-elephant conflicts; Human-elephant conflicts.  

E-Print Network [OSTI]

?? It is widely recognized that human-wildlife conflicts can reduce farmers’ support for long-term species conservation. The subject of human-elephant conflicts is highly relevant in… (more)

Olsson, Linnea

2014-01-01T23:59:59.000Z

389

Biosphere Process Model Report  

SciTech Connect (OSTI)

To evaluate the postclosure performance of a potential monitored geologic repository at Yucca Mountain, a Total System Performance Assessment (TSPA) will be conducted. Nine Process Model Reports (PMRs), including this document, are being developed to summarize the technical basis for each of the process models supporting the TSPA model. These reports cover the following areas: (1) Integrated Site Model; (2) Unsaturated Zone Flow and Transport; (3) Near Field Environment; (4) Engineered Barrier System Degradation, Flow, and Transport; (5) Waste Package Degradation; (6) Waste Form Degradation; (7) Saturated Zone Flow and Transport; (8) Biosphere; and (9) Disruptive Events. Analysis/Model Reports (AMRs) contain the more detailed technical information used to support TSPA and the PMRs. The AMRs consists of data, analyses, models, software, and supporting documentation that will be used to defend the applicability of each process model for evaluating the postclosure performance of the potential Yucca Mountain repository system. This documentation will ensure the traceability of information from its source through its ultimate use in the TSPA-Site Recommendation (SR) and in the National Environmental Policy Act (NEPA) analysis processes. The objective of the Biosphere PMR is to summarize (1) the development of the biosphere model, and (2) the Biosphere Dose Conversion Factors (BDCFs) developed for use in TSPA. The Biosphere PMR does not present or summarize estimates of potential radiation doses to human receptors. Dose calculations are performed as part of TSPA and will be presented in the TSPA documentation. The biosphere model is a component of the process to evaluate postclosure repository performance and regulatory compliance for a potential monitored geologic repository at Yucca Mountain, Nevada. The biosphere model describes those exposure pathways in the biosphere by which radionuclides released from a potential repository could reach a human receptor. Collectively, the potential human receptor and exposure pathways form the biosphere model. More detailed technical information and data about potential human receptor groups and the characteristics of exposure pathways have been developed in a series of AMRs and Calculation Reports.

J. Schmitt

2000-05-25T23:59:59.000Z

390

A STUDY ON THE INCAPACITATION MECHANISM MODEL OF THE JUCHIST AND MARXIST-LENINIST ARTICLES AGAINST THE CORE IMPLEMENTATION MECHANISM MODEL OF THE FUNDAMENTAL RIGHTS ARTICLES IN THE NORTH KOREAN CONSTITUTION: NORTH KOREA'S VIOLATIONS OF FUNDAMENTAL RIGHTS AND INTERNATIONAL HUMAN RIGHTS TREATIES  

E-Print Network [OSTI]

proposed by this dissertation is the incapacitation mechanism model of the Juchist and Marxist-Leninist Articles against the core implementation mechanism model of the Fundamental Rights Articles. The incapacitation mechanism model proves that all...

Jun, Woo-Suk

2014-05-31T23:59:59.000Z

391

Policy on Human Subjects Research Policy on Human Subjects  

E-Print Network [OSTI]

Policy on Human Subjects Research 10/15/2014 Policy on Human Subjects Research I. Purpose and Scope requirements that the rights and welfare of human subjects receive adequate protection. This policy applies, except that research conducted or assigned as part of their coursework is governed by the Policy

Sridhar, Srinivas

392

Extending expectation propagation for graphical models  

E-Print Network [OSTI]

Graphical models have been widely used in many applications, ranging from human behavior recognition to wireless signal detection. However, efficient inference and learning techniques for graphical models are needed to ...

Qi, Yuan, 1974-

2005-01-01T23:59:59.000Z

393

Investigating impacts of natural and human-induced environmental changes on hydrological processes and flood hazards using a GIS-based hydrological/hydraulic model and remote sensing data  

E-Print Network [OSTI]

a GISbased hydrological and hydraulic modeling system, which incorporates state-of-the-art remote sensing data to simulate flood under various scenarios. The conceptual framework and technical issues of incorporating multi-scale remote sensing data...

Wang, Lei

2009-06-02T23:59:59.000Z

394

Effects of PGF{sub 2{alpha}} on human melanocytes and regulation of the FP receptor by ultraviolet radiation  

SciTech Connect (OSTI)

Prostaglandins are potent lipid hormones that activate multiple signaling pathways resulting in regulation of cellular growth, differentiation, and apoptosis. In the skin, prostaglandins are rapidly released by keratinocytes following ultraviolet radiation and are chronically present in inflammatory skin lesions. We have shown previously that melanocytes, which provide photoprotection to keratinocytes through the production of melanin, express several receptors for prostaglandins, including the PGE{sub 2} receptors EP{sub 1} and EP{sub 3} and the PGF{sub 2{alpha}} receptor FP, and that PGF{sub 2{alpha}} stimulates melanocyte dendricity. We now show that PGF{sub 2{alpha}} stimulates the activity and expression of tyrosinase, the rate-limiting enzyme in melanin synthesis. Analysis of FP receptor regulation showed that the FP receptor is regulated by ultraviolet radiation in melanocytes in vitro and in human skin in vivo. We also show that ultraviolet irradiation stimulates production of PGF{sub 2{alpha}} by melanocytes. These results show that PGF{sub 2{alpha}} binding to the FP receptor activates signals that stimulate a differentiated phenotype (dendricity and pigmentation) in melanocytes. The regulation of the FP receptor and the stimulation of production of PGF{sub 2{alpha}} in melanocytes in response to ultraviolet radiation suggest that PGF{sub 2{alpha}} could act as an autocrine factor for melanocyte differentiation.

Scott, Glynis [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)]. E-mail: Glynis_Scott@urmc.rochester.edu; Jacobs, Stacey [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Leopardi, Sonya [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Anthony, Frank A. [Schering-Plough HealthCare Products Inc., Memphis TN (United States); Learn, Doug [Charles River DDS, Argus Division, Horsham, PA (United States); Malaviya, Rama [University of Medicine and Dentistry, RWJMS, New Brunswick, NJ (United States); Pentland, Alice [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)

2005-04-01T23:59:59.000Z

395

Human Capital Management Accountability Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

2008-08-01T23:59:59.000Z

396

The Development of A Human Systems Simulation Laboratory: Strategic Direction  

SciTech Connect (OSTI)

The Human System Simulation Laboratory (HSSL) at the Idaho National Laboratory is one of few facilities of its kind that allows human factors researchers to evaluate various aspects of human performance and human system interaction for proposed reactor designs and upgrades. A basic system architecture, physical configuration and simulation capability were established to enable human factors researchers to support multiple, simultaneous simulations and also different power plant technologies. Although still evolving in terms of its technical and functional architecture, the HSSL is already proving its worth in supporting current and future nuclear industry needs for light water reactor sustainability and small modular reactors. The evolution of the HSSL is focused on continual physical and functional refinement to make it a fully equipped, reconfigurable facility where advanced research, testing and validation studies can be conducted on a wider range of reactor technologies. This requires the implementation of additional plant models to produce empirical research data on human performance with emerging human-system interaction technologies. Additional beneficiaries of this information include system designers and HRA practitioners. To ensure that results of control room crew studies will be generalizable to the existing and evolving fleet of US reactors, future expansion of the HSSL may also include other SMR plant models, plant-specific simulators and a generic plant model aligned to the current generation of pressurized water reactors (PWRs) and future advanced reactor designs. Collaboration with industry partners is also proving to be a vital component of the facility as this helps to establish a formal basis for current and future human performance experiments to support nuclear industry objectives. A long-range Program Plan has been developed for the HSSL to ensure that the facility will support not only the Department of Energy’s Light Water Reactor Sustainability Program, but also to provide human factors guidance for all future developments of the nuclear industry.

Jacques Hugo; Katya le Blanc; David Gertman

2012-07-01T23:59:59.000Z

397

Dynamic Human Reliability Analysis: Benefits and Challenges of Simulating Human Performance  

SciTech Connect (OSTI)

To date, there has been considerable work on dynamic event trees and other areas related to dynamic probabilistic safety assessment (PSA). The counterpart to these efforts in human reliability analysis (HRA) has centered on the development of specific methods to account for the dynamic nature of human performance. In this paper, the author posits that the key to dynamic HRA is not in the development of specific methods but in the utilization of cognitive modeling and simulation to produce a framework of data that may be used in quantifying the likelihood of human error. This paper provides an overview of simulation approaches to HRA; reviews differences between first, second, and dynamic generation HRA; and outlines potential benefits and challenges of this approach.

R. L. Boring

2007-06-01T23:59:59.000Z

398

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice  

E-Print Network [OSTI]

Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B ...

Chen, Qingfeng

399

Differential expression of RANK on Langerhans cells and CD45RA and CD45RO/CLA on T cells in developing human skin after birth.  

E-Print Network [OSTI]

??Die Haut, die Schnittstelle zwischen dem Körper und der Umgebung, ist das größte Organ des Körpers und hat zahlreiche Funktionen. Eine davon ist, dass die… (more)

Akguen, Johnnie

2010-01-01T23:59:59.000Z

400

Human Resources Organizational Development and Training 1  

E-Print Network [OSTI]

Human Resources Organizational Development and Training 1 Development Guide for Tufts Leadership Competencies Human Resources Training, Learning and Development Copyright © 2013 Tufts University Developed with Copperbeech Group Inc. #12;Human Resources Training, Learning and Development 2 #12;Human Resources Training

Dennett, Daniel

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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401

Automatic history matching of dual porosity system with wellbore storage and skin constant rate case  

E-Print Network [OSTI]

ACKNOWLEDGEMENTS TABLE OF CONTENTS LIST OF TABLES LIST OF FIGURES INTRODUCTION MATHEMATICAL MODEL HISTORY MATCHING MODEL MODEL VALIDATION Comparison with the Warren and Root Solution RESULTS Type Curves Automatic History Matching Behavior at Early... Page I Comparison of the Numerical Inversion Results with the Warren and Root Analytical Solution. 2 Comparison of the Numerical Inversion Results with the Agarwal et al. Analytical Solution. 3 Basic Type Curve Data 4 Simulated Drawdown Example...

Olarewaju, Joseph Shola

1985-01-01T23:59:59.000Z

402

Mentoring Human Performance - 12480  

SciTech Connect (OSTI)

Although the positive effects of implementing a human performance approach to operations can be hard to quantify, many organizations and industry areas are finding tangible benefits to such a program. Recently, a unique mentoring program was established and implemented focusing on improving the performance of managers, supervisors, and work crews, using the principles of Human Performance Improvement (HPI). The goal of this mentoring was to affect behaviors and habits that reliably implement the principles of HPI to ensure continuous improvement in implementation of an Integrated Safety Management System (ISMS) within a Conduct of Operations framework. Mentors engaged with personnel in a one-on-one, or one-on-many dialogue, which focused on what behaviors were observed, what factors underlie the behaviors, and what changes in behavior could prevent errors or events, and improve performance. A senior management sponsor was essential to gain broad management support. A clear charter and management plan describing the goals, objectives, methodology, and expected outcomes was established. Mentors were carefully selected with senior management endorsement. Mentors were assigned to projects and work teams based on the following three criteria: 1) knowledge of the work scope; 2) experience in similar project areas; and 3) perceived level of trust they would have with project management, supervision, and work teams. This program was restructured significantly when the American Reinvestment and Recovery Act (ARRA) and the associated funding came to an end. The program was restructured based on an understanding of the observations, attributed successes and identified shortfalls, and the consolidation of those lessons. Mentoring the application of proven methods for improving human performance was shown effective at increasing success in day-to-day activities and increasing confidence and level of skill of supervisors. While mentoring program effectiveness is difficult to measure, and return on investment is difficult to quantify, especially in complex and large organizations where the ability to directly correlate causal factors can be challenging, the evidence presented by Sydney Dekker, James Reason, and others who study the field of human factors does assert managing and reducing error is possible. Employment of key behaviors-HPI techniques and skills-can be shown to have a significant impact on error rates. Our mentoring program demonstrated reduced error rates and corresponding improvements in safety and production. Improved behaviors are the result, of providing a culture with consistent, clear expectations from leadership, and processes and methods applied consistently to error prevention. Mentoring, as envisioned and executed in this program, was effective in helping shift organizational culture and effectively improving safety and production. (authors)

Geis, John A.; Haugen, Christian N. [CALIBRE Systems, Inc., Alexandria, Virginia (United States)

2012-07-01T23:59:59.000Z

403

Human Genome Program  

SciTech Connect (OSTI)

The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

Not Available

1993-01-01T23:59:59.000Z

404

Human Resources | Jefferson Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLC HistoryVeteransto getEmployee Relations Human

405

Human Genome: DOE Origins  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinement plasmas inPortalAllBPA addressesHowHughHumanDecoding

406

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,Human Resources

407

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,Human

408

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,HumanAppraisal

409

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman Resources

410

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman Resources

411

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman ResourcesCode

412

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman ResourcesCode

413

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman

414

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHumanAppraisal

415

PIA - Human Resources - Personal Information Change Request ...  

Office of Environmental Management (EM)

PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National...

416

Multifactor Gaussian Process Models for Style-Content Separation Jack M. Wang jmwang@dgp.toronto.edu  

E-Print Network [OSTI]

novel animation from the model. 1. Introduction Using prior models of human motion to constrain independently, al- lowing nonlinear mappings from any partic- ular factor to the data. We learn models for human. This paper introduces a multifactor model for learning distributions of styles of human motion. We param

Toronto, University of

417

Human factors review for Severe Accident Sequence Analysis (SASA)  

SciTech Connect (OSTI)

The paper will discuss work being conducted during this human factors review including: (1) support of the Severe Accident Sequence Analysis (SASA) Program based on an assessment of operator actions, and (2) development of a descriptive model of operator severe accident management. Research by SASA analysts on the Browns Ferry Unit One (BF1) anticipated transient without scram (ATWS) was supported through a concurrent assessment of operator performance to demonstrate contributions to SASA analyses from human factors data and methods. A descriptive model was developed called the Function Oriented Accident Management (FOAM) model, which serves as a structure for bridging human factors, operations, and engineering expertise and which is useful for identifying needs/deficiencies in the area of accident management. The assessment of human factors issues related to ATWS required extensive coordination with SASA analysts. The analysis was consolidated primarily to six operator actions identified in the Emergency Procedure Guidelines (EPGs) as being the most critical to the accident sequence. These actions were assessed through simulator exercises, qualitative reviews, and quantitative human reliability analyses. The FOAM descriptive model assumes as a starting point that multiple operator/system failures exceed the scope of procedures and necessitates a knowledge-based emergency response by the operators. The FOAM model provides a functionally-oriented structure for assembling human factors, operations, and engineering data and expertise into operator guidance for unconventional emergency responses to mitigate severe accident progression and avoid/minimize core degradation. Operators must also respond to potential radiological release beyond plant protective barriers. Research needs in accident management and potential uses of the FOAM model are described. 11 references, 1 figure.

Krois, P.A.; Haas, P.M.; Manning, J.J.; Bovell, C.R.

1984-01-01T23:59:59.000Z

418

Effects of the co-carcinogen catechol on benzo(a)pyrene metabolism and DNA adduct formation in mouse skin  

SciTech Connect (OSTI)

We have studied the effects of the co-carcinogen catechol (1,2-dihydroxybenzene) on the metabolic activation of (/sup 3/H) benzo(a)pyrene (BaP) in mouse skin, in vivo and on the binding of BaP metabolites to DNA and protein at intervals from 0.5-24 h. Upon topical application of 0.015 mg (/sup 3/H)BaP and 0.25 or 0.5 mg catechol per mouse, catechol had little effect on the total amount of (/sup 3/H)BaP metabolized in mouse skin, but it affected the relative proportions of (/sup 3/H)BaP metabolites. Catechol (0.5 mg/mouse) decreased the proportion of water-soluble (/sup 3/H)BaP metabolites, ethyl acetate-soluble polar metabolites and quinones, but doubled the levels of unconjugated 3-hydroxy-BaP at all measured intervals after treatment. Catechol also caused a small increase in the levels of trans-7,8-dihydroxy-7,8-dihydroBaP and trans-9,10-dihydroxy-9,10-dihydroBaP 0.5 h after treatment. Two hours after treatment, the levels of these metabolites subsided to those of the controls. Catechol did not affect the levels of glutathione conjugates of BaP. However, it caused a decrease in glucuronide and sulphate conjugate formation from BaP. Catechol caused an approximately 2-fold increase in the formation of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydroBaP (BPDE) DNA adducts and elevated the ratio of anti-syn-BPDE-DNA adducts 1.6 to 2.9-fold. Catechol treatment increased the radioactivity associated with epidermal proteins after (/sup 3/H)BaP application. Because catechol increased levels of 3-hydroxyBaP, we considered the possibility that 3-hydroxyBaP might enhance the tumor initiating activities of BaP or BPDE in mouse skin; a bioassay demonstrated that this was not the case. The results of this study indicate that one important effect of catechol related to its co-carcinogenicity is its ability to enhance formation of anti-BPDE-DNA adducts in mouse skin.

Melikian, A.A.; Leszczynska, J.M.; Hecht, S.S.; Hoffmann, D.

1986-01-01T23:59:59.000Z

419

Human subjects research handbook: Protecting human research subjects. Second edition  

SciTech Connect (OSTI)

This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

NONE

1996-01-30T23:59:59.000Z

420

E-Print Network 3.0 - antigen-induced arthritis model Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

suppress arthritis in the animal model, the results in human RA... -induced arthritis (CIA), an experimental model of RA. ... Source: Park, Jong-Sang - School of Chemistry, Seoul...

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Modeling of Organizational Violence Violent Intent Modeling and Simulation (VIMS)  

E-Print Network [OSTI]

111 Modeling of Organizational Violence Violent Intent Modeling and Simulation (VIMS) Georgiy Bobashev, Burton Levine, Joe Eyerman, Michael Schwerin, and Richard Legault November 04, 2010 #12;2 VIMS Background #12;3 VIMS: Background · R&D sponsored by Human Factors Division at DHS S&T · Initial work

McShea, Daniel W.

422

Human-computer interface  

DOE Patents [OSTI]

The present invention provides a method of human-computer interfacing. Force feedback allows intuitive navigation and control near a boundary between regions in a computer-represented space. For example, the method allows a user to interact with a virtual craft, then push through the windshield of the craft to interact with the virtual world surrounding the craft. As another example, the method allows a user to feel transitions between different control domains of a computer representation of a space. The method can provide for force feedback that increases as a user's locus of interaction moves near a boundary, then perceptibly changes (e.g., abruptly drops or changes direction) when the boundary is traversed.

Anderson, Thomas G.

2004-12-21T23:59:59.000Z

423

Human Reliability Program Workshop  

SciTech Connect (OSTI)

A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

Landers, John; Rogers, Erin; Gerke, Gretchen

2014-05-18T23:59:59.000Z

424

Design of a building structural skin using multi-objective optimization techniques  

E-Print Network [OSTI]

Multi-disciplinary System Design Optimization was used to design the geometry and to select the materials for the structural facade of a building. A multi-objective optimization model was developed, capable of optimizing ...

Merello, Riccardo

2006-01-01T23:59:59.000Z

425

Side-by-side evaluation of a stressed-skin insulated-core panel house and a conventional stud-frame house. Final report  

SciTech Connect (OSTI)

Side-by-side energy testing and monitoring was conducted on two houses in Louisville, KY between January--March 1993. Both houses were identical except that one house was constructed with conventional US 2 by 4 studs and a truss roof while the other house was constructed with stress-skin insulated core panels for the walls and second floor ceiling. Air-tightness testing included fan pressurization by blower door, hour long tracer tests using sulphur hexafluoride, and two-week long time-averaged tests using perfluorocarbon tracers. An average of all the air-tightness test results showed the SSIC panel house to have 22 percent less air infiltration than the frame house. Air-tightness testing resulted in a recommendation that both houses have a fresh air ventilation system installed to provide 0.35 air changes per hour continuously. Thermal insulation quality testing was by infrared imaging. Pressure differential testing resulted in recommendations to use sealed combustion appliances, and to allow for more return air flow from closed rooms. This can be accomplished by separate return ducts or transfer ducts which simply connect closed rooms to the main body with a short duct. The SSIC house UA was lower in both cases. By measurement, co-heating tests showed the SSIC panel house total UA to be 12 percent lower than the frame house. Short-term energy monitoring was also conducted for the two houses. A 17 day period of electric heating and a 14 day period of gas furnace heating was evaluated. Monitoring results showed energy savings for the panel house to be 12 percent during electric heating and 15 percent during gas heating. A comparison of the two monitoring periods showed that the lumped efficiency of the gas furnace and air distribution system for both houses was close to 80 percent. Simple regression models using Typical Meteorological Year weather data gave a preliminary prediction of seasonal energy savings between 14 and 20 percent.

Rudd, A.; Chandra, S.

1994-01-14T23:59:59.000Z

426

237Poverty and Human Capability Studies Poverty and Human  

E-Print Network [OSTI]

237Poverty and Human Capability Studies Poverty and Human CaPability StudieS (Pov) Core FaCulty: PROFESSORS beCKley*, GOLDSMITH, MARGAND The Shepherd Program for the interdisciplinary Study of Poverty and graduate studies can prepare them as futureprofessionalsandcitizenstoaddresstheproblems of poverty and how

Dresden, Gregory

427

227Poverty and Human Capability Studies Poverty AND HUMAN  

E-Print Network [OSTI]

227Poverty and Human Capability Studies Poverty AND HUMAN CAPABILIty StUDIeS (Pov) Core FACULty: PROFESSORS BeCKLey*, GOLDSMITH, MARGAND The Shepherd Program for the Interdisciplinary Study of Poverty studies can prepare them as future professionals and citizens to address the problems of poverty

Dresden, Gregory

428

Individual Differences in Human Reliability Analysis  

SciTech Connect (OSTI)

While human reliability analysis (HRA) methods include uncertainty in quantification, the nominal model of human error in HRA typically assumes that operator performance does not vary significantly when they are given the same initiating event, indicators, procedures, and training, and that any differences in operator performance are simply aleatory (i.e., random). While this assumption generally holds true when performing routine actions, variability in operator response has been observed in multiple studies, especially in complex situations that go beyond training and procedures. As such, complexity can lead to differences in operator performance (e.g., operator understanding and decision-making). Furthermore, psychological research has shown that there are a number of known antecedents (i.e., attributable causes) that consistently contribute to observable and systematically measurable (i.e., not random) differences in behavior. This paper reviews examples of individual differences taken from operational experience and the psychological literature. The impact of these differences in human behavior and their implications for HRA are then discussed. We propose that individual differences should not be treated as aleatory, but rather as epistemic. Ultimately, by understanding the sources of individual differences, it is possible to remove some epistemic uncertainty from analyses.

Jeffrey C. Joe; Ronald L. Boring

2014-06-01T23:59:59.000Z

429

The human activity of visualization  

E-Print Network [OSTI]

Griffin et al 2006 #12;Human-Computer Interaction: Software of the Mind each user has a setThe human activity of visualization cultural and psychological factors in representation; Gibbon 1998; Marcus 2000) conventions and metaphors of Westerners may not hold worldwide colors

Wright, Dawn Jeannine

430

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES  

E-Print Network [OSTI]

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES GUIDELINES Workforce Planning | Washington Square, San by the Workforce Planning Unit in Human Resources at SJSU. Process Consistent, defensible processes for evaluating of the recruitment. - At this meeting, the Workforce Planning analyst can provide contact information for search

Su, Xiao

431

Genetic and Economic Interaction in the Formation of Human Capital.  

E-Print Network [OSTI]

Genetic and Economic Interaction in the Formation of Human Capital. The Case of Obesity Pietro by changes in the incentives to invest. I take the model to the data using the Avon Longitudinal Study regulation of food intake, and shed light on the interdependence between genes and economic choices regarding

Mateo, Jill M.

432

Population stability, cooperation, and the invasibility of the human species  

E-Print Network [OSTI]

a mechanism for these outcomes by modifying a simple density-dependent population model to allow varying populations expanded out of Africa and spread rapidly across the majority of the earth's land surfacePopulation stability, cooperation, and the invasibility of the human species Marcus J. Hamiltona

Brown, James H.

433

Finite element analysis of human joints  

SciTech Connect (OSTI)

Our work focuses on the development of finite element models (FEMs) that describe the biomechanics of human joints. Finite element modeling is becoming a standard tool in industrial applications. In highly complex problems such as those found in biomechanics research, however, the full potential of FEMs is just beginning to be explored, due to the absence of precise, high resolution medical data and the difficulties encountered in converting these enormous datasets into a form that is usable in FEMs. With increasing computing speed and memory available, it is now feasible to address these challenges. We address the first by acquiring data with a high resolution C-ray CT scanner and the latter by developing semi-automated method for generating the volumetric meshes used in the FEM. Issues related to tomographic reconstruction, volume segmentation, the use of extracted surfaces to generate volumetric hexahedral meshes, and applications of the FEM are described.

Bossart, P.L.; Hollerbach, K.

1996-09-01T23:59:59.000Z

434

Human Reliability Analysis for Digital Human-Machine Interfaces  

SciTech Connect (OSTI)

This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

Ronald L. Boring

2014-06-01T23:59:59.000Z

435

The oncogenic action of ionizing radiation on rat skin. Final progress report, May 1, 1990--April 30, 1992  

SciTech Connect (OSTI)

The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/{mu}), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of {sup 14}C-thymidine. The return of these cells to S-phase a second time was detected by a second label ({sup 3}H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The {sup 14}C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with {sup 14}C increased after 42 hr and remained relatively constant thereafter.

Burns, F.J.; Garte, S.J.

1992-12-31T23:59:59.000Z

436

Abstract A model of "distributed cognition" is con-trasted with the "mental representation" model exempli-  

E-Print Network [OSTI]

of human cognition. By the same token, however, T&C's use of the MR model subjects their efforts to a setAbstract A model of "distributed cognition" is con- trasted with the "mental representation" model, this model characterizes cognition as "co-con- structed" by the participants. This approach is thus partic

Kirsh, David

437

Global Workspace Theory, its LIDA Model and the Underlying Neuroscience Stan Franklin, Steve Strain, Javier Snaider, Ryan McCall, Usef Faghihi  

E-Print Network [OSTI]

from animal (including human) cognition. Such architectures should faithfully model its insights from what is known from animal (including human) cognition be tested against empirical studies of humans and other animals. Such studies

Memphis, University of

438

Protecting People and the Planet a proposal to address the human rights impacts  

E-Print Network [OSTI]

Protecting People and the Planet a proposal to address the human rights impacts of climate change Francisco School of Law #12;#12;Protecting People and the Planet a proposal to address the human rights, and policy development. The IHRLC employs an interdisciplinary model that leverages the intellectual capital

Kammen, Daniel M.

439

Experimental comparison of torque control methods on an ankle exoskeleton during human walking  

E-Print Network [OSTI]

Experimental comparison of torque control methods on an ankle exoskeleton during human walking, a neuromuscular model, or electromyography. Controllers were implemented on a tethered ankle exoskeleton--Rehabilitation Robotics, Ankle Exoskeleton, Torque Control, Human-Robot Interaction I. INTRODUCTION Exoskeletons have been

Collins, Steven H.

440

MORPHOLOGY ANALYSIS OF HUMAN KNEE USING MR IMAGERY D. Chetverikov1,2, G. Renner1  

E-Print Network [OSTI]

MORPHOLOGY ANALYSIS OF HUMAN KNEE USING MR IMAGERY D. Chetverikov1,2, G. Renner1 1 Computer a novel system for building a 3D model of human knee based on a sequence MR images. The system applies tools can be applied to the analysis of the kinematic behaviour of the knee. In the medical practice, MR

Chetverikov, Dmitry

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Eunice Kennedy Shriver National Institute of Child Health and Human Development  

E-Print Network [OSTI]

, and Dose Response · Building in vitro Models for Environmental Research · Early Life Determinants the life course and beyond, to future generations. Advancing our understanding of the environmental impacts of Air Pollution on Human Health · Water Pollution and Human Health · Multiple Exposures, Mixtures

Rau, Don C.

442

Tracking of Multiple Faces for Human-Computer Interfaces and Virtual Environments  

E-Print Network [OSTI]

Tracking of Multiple Faces for Human-Computer Interfaces and Virtual Environments Fu Jie Huang present a tracking software library based on this algorithm. This library can be applied to human-computer based on statistical color modeling and the deformable template. We then expand the algorithm to track

Beimel, Amos

443

Electronic Tattoo Grafts Gadgets to Skin : Discovery News http://news.discovery.com/tech/ultrathin-device-detects-brain-signals-110811.html[8/14/2011 6:37:10 AM  

E-Print Network [OSTI]

Electronic Tattoo Grafts Gadgets to Skin : Discovery News http://news.discovery.com/tech/ultrathin-device-detects-brain-signals-110811.html[8/14/2011 6:37:10 AM] ELECTRONIC TATTOO GRAFTS GADGETS TO SKIN The ultrathin device can stick created skinlike electronics that stick to the body like temporary tattoos. The device contains ultrathin

Rogers, John A.

444

Electric dipole response of 208Pb from proton inelastic scattering: constraints on neutron skin thickness and symmetry energy  

E-Print Network [OSTI]

The electric dipole (E1) response of 208Pb has been precisely determined by measuring Coulomb excitation induced by proton scattering at very forward angles. The electric dipole polarizability, defined as inverse energy-weighted sum rule of the E1 strength, has been extracted as 20.1+-0.6 fm^3. The data can be used to constrain the neutron skin thickness of 208Pb to 0.168(+-0.009)_expt(+-0.013)_theo(+-0.021)_est fm, where the subscript "expt" refers to the experimental uncertainty, "theor" to the theoretical confidence band and "est" to the uncertainty associated with the estimation of the symmetry energy at the saturation density. In addition, a constraint band has been extracted in the plane of the symmetry energy (J) and its slope parameter (L) at the saturation density.

A. Tamii; P. von Neumann-Cosel; I. Poltoratska

2013-10-02T23:59:59.000Z

445

Basic model Basic model  

E-Print Network [OSTI]

Early days Basic model Literature Classical literature Bayes pre-MCMC Bayes post-MCMC Basic model systems via latent factors Hedibert Freitas Lopes Booth School of Business University of Chicago Col / 66 #12;Early days Basic model Literature Classical literature Bayes pre-MCMC Bayes post-MCMC Basic

Liu, I-Shih

446

Human genome. 1993 Program report  

SciTech Connect (OSTI)

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Not Available

1994-03-01T23:59:59.000Z

447

Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect  

SciTech Connect (OSTI)

Sulfur mustard (HD, SM), is a chemical warfare agent that within hours causes extensive blistering at the dermal-epidermal junction of skin. To better understand the progression of SM-induced blistering, gene expression profiling for mouse skin was performed after a single high dose of SM exposure. Punch biopsies of mouse ears were collected at both early and late time periods following SM exposure (previous studies only considered early time periods). The biopsies were examined for pathological disturbances and the samples further assayed for gene expression profiling using the Affymetrix microarray analysis system. Principal component analysis and hierarchical cluster analysis of the differently expressed genes, performed with ArrayTrack showed clear separation of the various groups. Pathway analysis employing the KEGG library and Ingenuity Pathway Analysis (IPA) indicated that cytokine-cytokine receptor interaction, cell adhesion molecules (CAMs), and hematopoietic cell lineage are common pathways affected at different time points. Gene ontology analysis identified the most significantly altered biological processes as the immune response, inflammatory response, and chemotaxis; these findings are consistent with other reported results for shorter time periods. Selected genes were chosen for RT-PCR verification and showed correlations in the general trends for the microarrays. Interleukin 1 beta was checked for biological analysis to confirm the presence of protein correlated to the corresponding microarray data. The impact of a matrix metalloproteinase inhibitor, MMP-2/MMP-9 inhibitor I, against SM exposure was assessed. These results can help in understanding the molecular mechanism of SM-induced blistering, as well as to test the efficacy of different inhibitors.

Gerecke, Donald R. [Environmental and Occupational Health Sciences Institute (EOHSI), a Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States)], E-mail: gerecke@eohsi.rutgers.edu; Chen Minjun; Isukapalli, Sastry S.; Gordon, Marion K.; Chang, Y.-C. [Environmental and Occupational Health Sciences Institute (EOHSI), Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Tong Weida [US FDA, National Center for Toxicological Research, Jefferson, AK (United States); Androulakis, Ioannis P. [Department of Biomedical Engineering, Rutgers, State University of New Jersey, Piscataway, NJ (United States); Georgopoulos, Panos G. [Environmental and Occupational Health Sciences Institute (EOHSI), Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States)

2009-01-15T23:59:59.000Z

448

Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells  

SciTech Connect (OSTI)

Cadmium is a toxic heavy metal which is environmentally and occupationally relevant. The mechanisms underlying cadmium-induced autophagy are not yet completely understood. The present study shows that cadmium induces autophagy, as demonstrated by the increase of LC3-II formation and the GFP-LC3 puncta cells. The induction of autophagosomes was directly visualized by electron microscopy in cadmium-exposed skin epidermal cells. Blockage of LKB1 or AMPK by siRNA transfection suppressed cadmium-induced autophagy. Cadmium-induced autophagy was inhibited in dominant-negative AMPK-transfected cells, whereas it was accelerated in cells transfected with the constitutively active form of AMPK. mTOR signaling, a negative regulator of autophagy, was downregulated in cadmium-exposed cells. In addition, cadmium generated reactive oxygen species (ROS) at relatively low levels, and caused poly(ADP-ribose) polymerase-1 (PARP) activation and ATP depletion. Inhibition of PARP by pharmacological inhibitors or its siRNA transfection suppressed ATP reduction and autophagy in cadmium-exposed cells. Furthermore, cadmium-induced autophagy signaling was attenuated by either exogenous addition of catalase and superoxide dismutase, or by overexpression of these enzymes. Consequently, these results suggest that cadmium-mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells. - Highlights: > Cadmium, a toxic heavy metal, induces autophagic cell death through ROS-dependent activation of the LKB1-AMPK signaling. > Cadmium generates intracellular ROS at low levels and this leads to severe DNA damage and PARP activation, resulting in ATP depletion, which are the upstream events of LKB1-AMPK-mediated autophagy. > This novel finding may contribute to further understanding of cadmium-mediated diseases.

Son, Young-Ok; Wang Xin; Hitron, John Andrew [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States); Zhang Zhuo [Department of Preventive Medicine and Environmental Health, College of Public Health, University of Kentucky, Lexington, KY 40536-0305 (United States); Cheng Senping; Budhraja, Amit; Ding Songze [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States); Lee, Jeong-Chae [Institute of Oral Biosciences and BK21 Program, Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Shi Xianglin, E-mail: xshi5@email.uky.edu [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States)

2011-09-15T23:59:59.000Z

449

Proton dose assessment to the human eye using Monte Carlo n-particle transport code (MCNPX)  

E-Print Network [OSTI]

The objective of this project was to develop a simple MCNPX model of the human eye to approximate dose delivered from proton therapy. The calculated dose included that due to proton interactions and secondary interactions, which included multiple...

Oertli, David Bernhardt

2009-05-15T23:59:59.000Z

450

Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells  

E-Print Network [OSTI]

The objective of this project is to establish a model system to study the direct effect, the bystander effect and the combinational effect of alpha-particle irradiations of human prostate tumor cells, toward the goal of ...

Wang, Rong, Ph. D. Massachusetts Institute of Technology

2005-01-01T23:59:59.000Z

451

Constraints on the symmetry energy and neutron skins from experiments and theory  

E-Print Network [OSTI]

The symmetry energy contribution to the nuclear Equation of State (EoS) impacts various phenomena in nuclear astrophysics, nuclear structure, and nuclear reactions. Its determination is a key objective of contemporary nuclear physics with consequences for the understanding of dense matter within neutron stars. We examine the results of laboratory experiments that have provided initial constraints on the nuclear symmetry energy and its density dependence at and somewhat below normal nuclear matter density. Some of these constraints have been derived from properties of nuclei. Others have been derived from the nuclear response to electroweak and hadronic probes. We also examine the most frequently used theoretical models that predict the symmetry energy and its slope. By comparing existing constraints on the symmetry pressure to theories, we demonstrate how the contribution of the three-body force, an essential ingredient in neutron matter models, can be determined.

Tsang, M B; Camera, F; Danielewicz, P; Gandolfi, S; Hebeler, K; Horowitz, C J; Lee, Jenny; Lynch, W G; Kohley, Z; Lemmon, R; Moller, P; Murakami, T; Riordan, S; Roca-Maza, X; Sammarruca, F; Steiner, A W; Vidaña, I; Yennello, S J

2012-01-01T23:59:59.000Z

452

Constraints on the symmetry energy and neutron skins from experiments and theory  

E-Print Network [OSTI]

The symmetry energy contribution to the nuclear Equation of State (EoS) impacts various phenomena in nuclear astrophysics, nuclear structure, and nuclear reactions. Its determination is a key objective of contemporary nuclear physics with consequences for the understanding of dense matter within neutron stars. We examine the results of laboratory experiments that have provided initial constraints on the nuclear symmetry energy and its density dependence at and somewhat below normal nuclear matter density. Some of these constraints have been derived from properties of nuclei. Others have been derived from the nuclear response to electroweak and hadronic probes. We also examine the most frequently used theoretical models that predict the symmetry energy and its slope. By comparing existing constraints on the symmetry pressure to theories, we demonstrate how the contribution of the three-body force, an essential ingredient in neutron matter models, can be determined.

M. B. Tsang; J. R. Stone; F. Camera; P. Danielewicz; S. Gandolfi; K. Hebeler; C. J. Horowitz; Jenny Lee; W. G. Lynch; Z. Kohley; R. Lemmon; P. Moller; T. Murakami; S. Riordan; X. Roca-Maza; F. Sammarruca; A. W. Steiner; I. Vidaña; S. J. Yennello

2012-04-02T23:59:59.000Z

453

Title: Refreshable tactile graphics using a lateral skin deformation device Author(s): Levesque V.1, Hayward V.1, Petit G.2, Dufresne A.2  

E-Print Network [OSTI]

Title: Refreshable tactile graphics using a lateral skin deformation device Author(s): Levesque V.1: Tactile graphics are useful to convey spatial information and concepts to visually impaired persons with maps, mathematical diagrams and other types of illustrations. Unfortunately, tactile graphics

Hayward, Vincent

454

Robot Learning Learning Models for Control  

E-Print Network [OSTI]

in order to ensure the safe interaction with human beings. In contrast, traditional industrial robots45 Robot Learning Learning Models for Control Duy Nguyen-Tuong, Matthias Seeger1, Jan Peters Bringing anthropomorphic robots into human daily life requires backdrivable robots with compliant control

455

Corporate Human Resources Information Services (CHIRS) PIA, Office...  

Broader source: Energy.gov (indexed) [DOE]

Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol...

456

The Politics of Human Rights in Argentina  

E-Print Network [OSTI]

Valente,  Marcela.  “Argentina’s  Biggest  Human  Rights  Motor  is  Linked  to  Argentina’s  ‘Dirty  War’”.   New  fortune  of  my  heart.   Argentina's  1985  human  rights  

Brysk, Alison

2013-01-01T23:59:59.000Z

457

Scientists Help Define the Healthy Human Microbiome  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Scientists Help Define the Healthy Human Microbiome Scientists Help Define the Healthy Human Microbiome Computing, bioinformatics, and microbial ecology resources play key role in...

458

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

) by coordinating budget submissions, estimating and preparing cost projections, liaising with PurchasingHUMAN RESOURCES SIMON FRASER UNIVERSITY ADMINISTRATIVE & PROFESSIONAL JOB DESCRIPTION Position of the position in one or two sentences. Manages the Department's operating, capital, temporary instruction

459

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

funding priorities, budget consideration, application requirements, University policies and proceduresHUMAN RESOURCES SIMON FRASER UNIVERSITY ADMINISTRATIVE & PROFESSIONAL JOB DESCRIPTION Position to Canadian and international funding agencies. The incumbent will assist with the writing and reviewing

460

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

. The position is responsible for developing test scenarios, responding to system problems by investigating regarding the design of testing scenarios and scripts and how to evaluate outcomes. Makes decisions1 HUMAN RESOURCES SIMON FRASER UNIVERSITY TEMPORARY ADMINISTRATIVE & PROFESSIONAL STAFF POSITION

Note: This page contains sample records for the topic "human skin model" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

ORISE: Human Subjects Research Database  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of...

462

Robot manipulation in human environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron Ladd, 1972-

2007-01-01T23:59:59.000Z

463

Robot Manipulation in Human Environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron

2007-01-16T23:59:59.000Z

464

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

1996-09-30T23:59:59.000Z

465

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

1996-09-30T23:59:59.000Z

466

Coördinating human-robot communication  

E-Print Network [OSTI]

As robots begin to emerge from the cloisters of industrial and military applications and enter the realms of coöperative partners for people, one of the most important facets of human-robot interaction (HRI) will be ...

Brööks, Andrëw G. (Brööks Zoz)

2007-01-01T23:59:59.000Z

467

Director Human Resources Assoc Director  

E-Print Network [OSTI]

Director ­ Human Resources Assoc Director Workforce Planning & Organisational Change Director) - Organisational change - Workforce planning - Grievance & performance mgt support - Performance management line and not a formal Branch ** Includes Classifications ANU Search Workforce Planning* Remunerations

Botea, Adi

468

Unravelling daily human mobility motifs  

E-Print Network [OSTI]

Human mobility is differentiated by time scales. While the mechanism for long time scales has been studied, the underlying mechanism on the daily scale is still unrevealed. Here, we uncover the mechanism responsible for ...

Schneider, Christian M.

469

Reservations to human rights treaties   

E-Print Network [OSTI]

This thesis examines the default application of the 1969 Vienna Convention on the Law of Treaties reservation rules to reservations to human rights treaties. The contemporary practice of formulating reservations allows ...

McCall-Smith, Kasey Lowe

2012-06-26T23:59:59.000Z

470

Human Factors of Reporting Systems  

E-Print Network [OSTI]

Johnson,C.W. P. Carayon (ed.), A Handbook of Human Factors and Ergonomics in Healthcare and Patient Safety, Lawrence Erlbaum, London, UK. pp 715-750 Lawrence Erlbaum Associates

Johnson, C.W.

471

Error Modeling in the ACT-R Production System Christian Lebire  

E-Print Network [OSTI]

Error Modeling in the ACT-R Production System Christian Lebière Department of Psychology Carnegie to extend the ACT-R production system to model human errors in the performance of a high-level cognitive be successfully duplicated in production system models. Introduction ACT-R (Anderson, 1993) is a model of human

Reder, Lynne

472

Human Genome Education Program  

SciTech Connect (OSTI)

The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

Richard Myers; Lane Conn

2000-05-01T23:59:59.000Z

473

Protection of Human Research Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Cancels DOE O 443.1A and DOE P 443.1A.

2009-12-09T23:59:59.000Z

474

Framework for Human-Automation Collaboration: Conclusions from Four Studies  

SciTech Connect (OSTI)

The Human Automation Collaboration (HAC) research project is investigating how advanced technologies that are planned for Advanced Small Modular Reactors (AdvSMR) will affect the performance and the reliability of the plant from a human factors and human performance perspective. The HAC research effort investigates the consequences of allocating functions between the operators and automated systems. More specifically, the research team is addressing how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. Oxstrand et al. (2013 - March) describes the efforts conducted by the researchers to identify the research needs for HAC. The research team reviewed the literature on HAC, developed a model of HAC, and identified gaps in the existing knowledge of human-automation collaboration. As described in Oxstrand et al. (2013 – June), the team then prioritized the research topics identified based on the specific needs in the context of AdvSMR. The prioritization was based on two sources of input: 1) The preliminary functions and tasks, and 2) The model of HAC. As a result, three analytical studies were planned and conduced; 1) Models of Teamwork, 2) Standardized HAC Performance Measurement Battery, and 3) Initiators and Triggering Conditions for Adaptive Automation. Additionally, one field study was also conducted at Idaho Falls Power.

Johanna Oxstrand; Katya L. Le Blanc; John O'Hara; Jeffrey C. Joe; April M. Whaley; Heather Medema

2013-11-01T23:59:59.000Z

475

In vitro models for airway epithelial cell culture  

E-Print Network [OSTI]

This work is about the development of a physiologically relevant model of the human airway. Various factors such as the cell model, physiochemical factors such as the cell substrate properties including its stiffness, shear ...

Sivathanu, Vivek

2013-01-01T23:59:59.000Z

476

Accommodating complexity and human behaviors in decision analysis.  

SciTech Connect (OSTI)

This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan; Strip, David R.; Hirsch, Gary B.; Bastian, Mark S.; Braithwaite, Karl R.; Homer, Jack [Homer Consulting

2007-11-01T23:59:59.000Z

477

Statistical models for natural scene data   

E-Print Network [OSTI]

This thesis considers statistical modelling of natural image data. Obtaining advances in this field can have significant impact for both engineering applications, and for the understanding of the human visual system. Several recent advances...

Kivinen, Jyri Juhani

2014-06-27T23:59:59.000Z

478

Development and Application of Earth System Models  

E-Print Network [OSTI]

The global environment is a complex and dynamic system. Earth system modeling is needed to help understand changes in interacting subsystems, elucidate the influence of human activities, and explore possible future changes. ...

Prinn, Ronald G.

479

Handbook of human-reliability analysis with emphasis on nuclear power plant applications. Final report  

SciTech Connect (OSTI)

The primary purpose of the Handbook is to present methods, models, and estimated human error probabilities (HEPs) to enable qualified analysts to make quantitative or qualitative assessments of occurrences of human errors in nuclear power plants (NPPs) that affect the availability or operational reliability of engineered safety features and components. The Handbook is intended to provide much of the modeling and information necessary for the performance of human reliability analysis (HRA) as a part of probabilistic risk assessment (PRA) of NPPs. Although not a design guide, a second purpose of the Handbook is to enable the user to recognize error-likely equipment design, plant policies and practices, written procedures, and other human factors problems so that improvements can be considered. The Handbook provides the methodology to identify and quantify the potential for human error in NPP tasks.

Swain, A D; Guttmann, H E

1983-08-01T23:59:59.000Z

480

Sequence modelling and an extensible data model for genomic database  

SciTech Connect (OSTI)

The Human Genome Project (HGP) plans to sequence the human genome by the beginning of the next century. It will generate DNA sequences of more than 10 billion bases and complex marker sequences (maps) of more than 100 million markers. All of these information will be stored in database management systems (DBMSs). However, existing data models do not have the abstraction mechanism for modelling sequences and existing DBMS's do not have operations for complex sequences. This work addresses the problem of sequence modelling in the context of the HGP and the more general problem of an extensible object data model that can incorporate the sequence model as well as existing and future data constructs and operators. First, we proposed a general sequence model that is application and implementation independent. This model is used to capture the sequence information found in the HGP at the conceptual level. In addition, abstract and biological sequence operators are defined for manipulating the modelled sequences. Second, we combined many features of semantic and object oriented data models into an extensible framework, which we called the Extensible Object Model'', to address the need of a modelling framework for incorporating the sequence data model with other types of data constructs and operators. This framework is based on the conceptual separation between constructors and constraints. We then used this modelling framework to integrate the constructs for the conceptual sequence model. The Extensible Object Model is also defined with a graphical representation, which is useful as a tool for database designers. Finally, we defined a query language to support this model and implement the query processor to demonstrate the feasibility of the extensible framework and the usefulness of the conceptual sequence model.

Li, Peter Wei-Der (California Univ., San Francisco, CA (United States) Lawrence Berkeley Lab., CA (United States))

1992-01-01T23:59:59.000Z

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481

Sequence modelling and an extensible data model for genomic database  

SciTech Connect (OSTI)

The Human Genome Project (HGP) plans to sequence the human genome by the beginning of the next century. It will generate DNA sequences of more than 10 billion bases and complex marker sequences (maps) of more than 100 million markers. All of these information will be stored in database management systems (DBMSs). However, existing data models do not have the abstraction mechanism for modelling sequences and existing DBMS`s do not have operations for complex sequences. This work addresses the problem of sequence modelling in the context of the HGP and the more general problem of an extensible object data model that can incorporate the sequence model as well as existing and future data constructs and operators. First, we proposed a general sequence model that is application and implementation independent. This model is used to capture the sequence information found in the HGP at the conceptual level. In addition, abstract and biological sequence operators are defined for manipulating the modelled sequences. Second, we combined many features of semantic and object oriented data models into an extensible framework, which we called the ``Extensible Object Model``, to address the need of a modelling framework for incorporating the sequence data model with other types of data constructs and operators. This framework is based on the conceptual separation between constructors and constraints. We then used this modelling framework to integrate the constructs for the conceptual sequence model. The Extensible Object Model is also defined with a graphical representation, which is useful as a tool for database designers. Finally, we defined a query language to support this model and implement the query processor to demonstrate the feasibility of the extensible framework and the usefulness of the conceptual sequence model.

Li, Peter Wei-Der [California Univ., San Francisco, CA (United States); [Lawrence Berkeley Lab., CA (United States)

1992-01-01T23:59:59.000Z

482

Computationally Efficient Cardiac Bioelectricity Models Toward Whole-Heart Simulation  

E-Print Network [OSTI]

Computationally Efficient Cardiac Bioelectricity Models Toward Whole-Heart Simulation Nathan A of developing new insights and techniques in simulating the electrical behavior of the human heart. While very A computationally feasible whole-heart model could be invaluable in the study of human heart pathology

Branicky, Michael S.

483

Low-Income Weatherization: The Human Dimension  

Broader source: Energy.gov [DOE]

This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

484

Haptic Human Interfaces for Robotic Telemanipulation  

E-Print Network [OSTI]

While discussing human perception mechanisms , Sekuler and Balke [1] eloquently stated that ... whether of regard. Human haptic perception is the result of a complex investigatory dexterous manipulation act-level perception and task planning abilities of a human operator equipped with adequate human interfaces [6

Payeur, Pierre

485

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

62 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

486

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

63 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

487

ATHENA, the Desktop Human "Body"  

SciTech Connect (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2014-09-29T23:59:59.000Z

488

ATHENA, the Desktop Human "Body"  

ScienceCinema (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2015-01-05T23:59:59.000Z

489

MONGA, GEISLER, AND EVANS: HUMAN VISUAL SYSTEM MODELS 1 Linear, Color Separable, Human Visual System  

E-Print Network [OSTI]

does not have perceptual meaning in Authors are with the Center for Perceptual Systems, The University space where Eu- clidean distance has perceptual meaning. This paper eval- uates color spaces for vector error lter optimization. In order of increasing quality, the color spaces are YIQ, YUV, opponent

Evans, Brian L.

490

Computational modeling of primary blast effects on the human brain  

E-Print Network [OSTI]

Since the beginning of the military conflicts in Iraq and Afghanistan, there have been over 250,000 diagnoses of traumatic brain injury (TBI) in the U.S. military, with the majority of incidents caused by improvised explosive ...

Nyein, Michelle K. (Michelle Kyaw)

2013-01-01T23:59:59.000Z

491

RESEARCH PAPER Modelling the Human Immune System by Combining  

E-Print Network [OSTI]

Approaches Nicolas Rapin & Can Kesmir & Sune Frankild & Morten Nielsen & Claus Lundegaard & Søren Brunak

Utrecht, Universiteit

492

Engineering human hepatic tissue for modeling liver-stage malaria  

E-Print Network [OSTI]

The Plcsmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, ...

Ng, Shengyong

2014-01-01T23:59:59.000Z

493

A New Model for Image-Based Humanities Computing  

E-Print Network [OSTI]

scholarship and “digital imaging technologies,” as Matthew Kirschenbaum has pointed out. Many exciting things have been and are being done in this field, as multifaceted multimedia projects and “advanced visual and visualization tools” continue to be produced...

Brown, Jacob Hohmann

2009-05-15T23:59:59.000Z

494

Engineered microtissue platforms for modeling human pathophysiology and drug metabolism  

E-Print Network [OSTI]

Over 50% of all drug candidates entering clinical trials are abandoned due to insufficient efficacy or unexpected safety issues despite extensive pre-clinical testing. Liver metabolites that cause toxicity or other side ...

Li, Cheri Yingjie

2013-01-01T23:59:59.000Z

495

Modeling toxic endpoints for improving human health risk assessment  

E-Print Network [OSTI]

Risk assessment procedures for mixtures of polycyclic aromatic hydrocarbons (PAHs) present a problem due to the lack of available potency and toxicity data on mixtures and individual compounds. This study examines the toxicity of parent compound...

Bruce, Erica Dawn

2009-05-15T23:59:59.000Z

496

The MIT Emissions Prediction and Policy Analysis (EPPA) Model: Version 4  

E-Print Network [OSTI]

The Emissions Prediction and Policy Analysis (EPPA) model is the part of the MIT Integrated Global Systems Model (IGSM) that represents the human systems. EPPA is a recursive-dynamic multi-regional general equilibrium model ...

Paltsev, Sergey.

497

Mnemonic Structure and Sociality: A Computational Agent-Based Simulation Model  

E-Print Network [OSTI]

Mnemonic Structure and Sociality: A Computational Agent-Based Simulation Model Claudio Cioffi-agent social simulation models are designed with agents lacking explicit internal information transformations affect human and social dynamics? Most computational multi-agent social simulation models

George Mason University

498

Queuing models System dynamics models  

E-Print Network [OSTI]

models Value chain models Business Model / Organizational Perspective Process Perspective Information#12;#12;#12;#12;Queuing models System dynamics models #12;#12;#12;#12;Blueprint or touchpoint

Glushko, Robert J.

499

Quantum Physics and Human Language  

E-Print Network [OSTI]

Human languages employ constructions that tacitly assume specific properties of the limited range of phenomena they evolved to describe. These assumed properties are true features of that limited context, but may not be general or precise properties of all the physical situations allowed by fundamental physics. In brief, human languages contain `excess baggage' that must be qualified, discarded, or otherwise reformed to give a clear account in the context of fundamental physics of even the everyday phenomena that the languages evolved to describe. The surest route to clarity is to express the constructions of human languages in the language of fundamental physical theory, not the other way around. These ideas are illustrated by an analysis of the verb `to happen' and the word `reality' in special relativity and the modern quantum mechanics of closed systems.

James B. Hartle

2006-12-19T23:59:59.000Z

500

Human Activity Detection from RGBD Images  

E-Print Network [OSTI]

Being able to detect and recognize human activities is important for making personal assistant robots useful in performing assistive tasks. The challenge is to develop a system that is low-cost, reliable in unstructured home settings, and also straightforward to use. In this paper, we use a RGBD sensor (Microsoft Kinect) as the input sensor, and present learning algorithms to infer the activities. Our algorithm is based on a hierarchical maximum entropy Markov model (MEMM). It considers a person's activity as composed of a set of sub-activities, and infers the two-layered graph structure using a dynamic programming approach. We test our algorithm on detecting and recognizing twelve different activities performed by four people in different environments, such as a kitchen, a living room, an office, etc., and achieve an average performance of 84.3% when the person was seen before in the training set (and 64.2% when the person was not seen before).

Sung, Jaeyong; Selman, Bart; Saxena, Ashutosh

2011-01-01T23:59:59.000Z