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Sample records for human remains funerary

  1. Hand-Held Analyzer Quickly Detects Buried Human Remains - Energy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hand-Held Analyzer Quickly Detects Buried Human Remains Oak Ridge National Laboratory ... and auditory cues to quickly alert investigators to the presence of buried human remains. ...

  2. UC 9-8-309 - Human Remains | Open Energy Information

    Open Energy Info (EERE)

    9 - Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-8-309 - Human RemainsLegal Abstract Governs discovery of...

  3. RCW - 68.50 Human Remains | Open Energy Information

    Open Energy Info (EERE)

    68.50 Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: RCW - 68.50 Human RemainsLegal Published NA Year...

  4. Medical Examiner/Coroner on the Handling of a Body/Human Remains...

    Office of Environmental Management (EM)

    Medical ExaminerCoroner on the Handling of a BodyHuman Remains that are Potentially Radiologically Contaminated Medical ExaminerCoroner on the Handling of a BodyHuman Remains ...

  5. MCA 22-3-801 - Human Skeletal Remains and Burial Site Protection...

    Open Energy Info (EERE)

    22-3-801 - Human Skeletal Remains and Burial Site Protection Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: MCA 22-3-801 -...

  6. Decontamination and Management of Human Remains Following Incidents of Hazardous Chemical Release

    SciTech Connect (OSTI)

    Hauschild, Veronique; Watson, Annetta Paule; Bock, Robert Eldon

    2012-01-01

    Abstract Objective: To provide specific procedural guidance and resources for identification, assessment, control, and mitigation of compounds that may contaminate human remains resulting from chemical attack or release. Design: A detailed technical, policy, and regulatory review is summarized. Setting: Guidance is suitable for civilian or military settings where human remains potentially contaminated with hazardous chemicals may be present. Settings would include sites of transportation accidents, natural disasters, terrorist or military operations, mortuary affairs or medical examiner processing and decontamination points, and similar. Patients, Participants: While recommended procedures have not been validated with actual human remains, guidance has been developed from data characterizing controlled experiments with fabrics, materiel, and laboratory animals. Main Outcome Measure(s): Presentation of logic and specific procedures for remains management, protection and decontamination of mortuary affairs personnel, as well as decision criteria for determining when remains are sufficiently decontaminated so as to pose no chemical health hazard. Results: Established procedures and existing equipment/materiel available for decontamination and verification provide appropriate and reasonable means to mitigate chemical hazards from remains. Extensive characterization of issues related to remains decontamination indicates that supra-lethal concentrations of liquid chemical warfare agent VX may prove difficult to decontaminate and verify in a timely fashion. Specialized personnel can and should be called upon to assist with monitoring necessary to clear decontaminated remains for transport and processing. Conclusions: Once appropriate decontamination and verification have been accomplished, normal procedures for remains processing and transport to the decedent s family and the continental United States can be followed.

  7. Enhanced Contaminated Human Remains Pouch: initial development and preliminary performance assessments

    SciTech Connect (OSTI)

    Iseli, A.M.; Kwen, H.D.; Ul-Alam, M.; Balasubramanian, M.; Rajagopalan, S.

    2011-11-07

    The objective is to produce a proof of concept prototype Enhanced Contaminated Human Remains Pouch (ECHRP) with self-decontamination capability to provide increased protection to emergency response personnel. The key objective was to decrease the concentration of toxic chemicals through the use of an absorbent and reactive nanocellulose liner. Additionally, nanomaterials with biocidal properties were developed and tested as a 'stand-alone' treatment. The setting was a private company research laboratory. The main outcome measures were production of a functional prototype. A functional prototype capable of mitigating the threats due to sulfur mustard, Soman, and a large variety of liquid and vapor toxic industrial chemicals was produced. Stand-alone biocidal treatment efficacy was validated. The ECHRP provides superior protection from both chemical and biological hazards to various emergency response personnel and human remains handlers.

  8. Medical Examiner/Coroner on the Handling of a Body/Human Remains that are Potentially Radiologically Contaminated

    Broader source: Energy.gov [DOE]

    The purpose of this Model Procedure is to identify precautions and provide guidance to Medical Examiners/Coroners on the handling of a body or human remains that are potentially contaminated with...

  9. Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro

    SciTech Connect (OSTI)

    Eke, Iris; Storch, Katja; Kaestner, Ina; Vehlow, Anne; Faethe, Christina; Mueller-Klieser, Wolfgang; Taucher-Scholz, Gisela; Temme, Achim; Schackert, Gabriele; Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden

    2012-11-15

    Purpose: Cell invasion represents one of the major determinants that treatment has failed for patients suffering from glioblastoma. Contrary findings have been reported for cell migration upon exposure to ionizing radiation. Here, the migration and invasion capability of glioblastoma cells on and in collagen type I were evaluated upon irradiation with X-rays or carbon ions. Methods and Materials: Migration on and invasion in collagen type I were evaluated in four established human glioblastoma cell lines exposed to either X-rays or carbon ions. Furthermore, clonogenic radiation survival, proliferation (5-bromo-2-deoxyuridine positivity), DNA double-strand breaks ({gamma}H2AX/53BP1-positive foci), and expression of invasion-relevant proteins (eg, {beta}1 integrin, FAK, MMP2, and MMP9) were explored. Migration and invasion assays for primary glioblastoma cells also were carried out with X-ray irradiation. Results: Neither X-ray nor carbon ion irradiation affected glioblastoma cell migration and invasion, a finding similarly observed in primary glioblastoma cells. Intriguingly, irradiated cells migrated unhampered, despite DNA double-strand breaks and reduced proliferation. Clonogenic radiation survival was increased when cells had contact with extracellular matrix. Specific inhibition of the {beta}1 integrin or proliferation-associated signaling molecules revealed a critical function of JNK, PI3K, and p38 MAPK in glioblastoma cell invasion. Conclusions: These findings indicate that X-rays and carbon ion irradiation effectively reduce proliferation and clonogenic survival without modifying the migration and invasion ability of glioblastoma cells in a collagen type I environment. Addition of targeted agents against members of the MAPK and PI3K signaling axis to conventional chemoradiation therapy seems potentially useful to optimize glioblastoma therapy.

  10. Remaining Challenges: Flicker

    Energy Savers [EERE]

    Naomi J. Miller, FIES, FIALD November 2015 DesignerSenior Staff Scientist Pacific Northwest National Laboratory Remaining Challenges: Flicker DOE SSL Workshop - Portland OR Dr....

  11. 43 CFR Part 10: Native American Graves Protection and Repatriation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Indian tribes, and Native Hawaiian organizations to Native American cultural items, including human remains, funerary objects, sacred objects, and objects of cultural patrimony. ...

  12. A.R.S. 41-844 | Open Energy Information

    Open Energy Info (EERE)

    Discusses the requirements if archeological or paleontological resources (including human remains and funerary objects) are discovered. Published NA Year Signed or Took Effect...

  13. Acquisition Letters Remaining In Effect

    Office of Energy Efficiency and Renewable Energy (EERE)

    From Acquisition Letter (Acquisition Letters (AL) that remain in effect are identified below. All other previously issued Als have been superseded by a formal rule-making, incorporated into other guidance, and/or canceled.)

  14. Diesel prices remain fairly stable

    U.S. Energy Information Administration (EIA) Indexed Site

    Diesel prices remain fairly stable The U.S. average retail price for on-highway diesel fuel slightly fell to $3.85 a gallon on Monday. That's down 6-tenths of a penny from a week ago, based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the New England region at 3.99 a gallon, down 7-tenths of a penny from a week ago. Prices were lowest in the Gulf Coast region at 3.74 a gallon, down 2.2 cents

  15. Los Alamos supercomputer remains fastest in world

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Supercomputer remains fastest in world Los Alamos supercomputer remains fastest in world The latest list of the TOP500 computers in the world continued to place the Roadrunner supercomputer as fastest in the world running the LINPACK benchmark. November 18, 2008 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma

  16. AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT Acquisition Letters (AL) that remain in effect are identified below. All other...

  17. AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT Acquisition Letters (AL)...

  18. Acquisition Letters Remaining in Effect | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    in Effect Acquisition Letters Remaining in Effect PF2009-40.pdf (768.41 KB) PF2009-40a - Attachment-Acquisition Letter 2009-06 - Acquisition Letters Remaining in Effect (133.09 KB) More Documents & Publications Acquisition Letters Remaining In Effect AL2007-05.doc� Acquisition Letters Remaining In Effect

  19. A National Forum on Demand Response: Results on What Remains...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A National Forum on Demand Response: Results on What Remains to Be Done to Achieve Its Potential - Measurement and Verification Working Group A National Forum on Demand Response: ...

  20. Demand for Food for People in Need Remains High Throughout the Year |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Demand for Food for People in Need Remains High Throughout the Year Demand for Food for People in Need Remains High Throughout the Year December 24, 2013 - 12:00pm Addthis Pictured are donations the Office of Human Capital at EM headquarters provided to the campaign. Pictured are donations the Office of Human Capital at EM headquarters provided to the campaign. WASHINGTON, D.C. - EM and its field sites donated 53,630 pounds - or 27 tons - of non-perishable items to a

  1. 2013-07 "Realign Remaining Milestones in the Consent Order" | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 7 "Realign Remaining Milestones in the Consent Order" 2013-07 "Realign Remaining Milestones in the Consent Order" It is the intent of this NNMCAB recommendation to encourage LANL to review all remaining tasks of the Consent Order and formulate a "Path Forward" for completion of these tasks in a manner which is both timely and most protective of human health and environment. This Path Forward shall be presented to the NNMCAB, NMED and public for comment,

  2. ORISE: Study finds foreign doctorate recipients' stay rates remain...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the United States remains high No evidence that visa restrictions are reducing stay rates, according to report FOR IMMEDIATE RELEASE Jan. 18, 2012 FY12-12 OAK RIDGE,...

  3. U.S. gasoline prices remain steady (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    average retail price for regular gasoline remained unchanged this week at 2.78 a gallon on Monday, based on the weekly price survey by the U.S. Energy Information Administration

  4. U.S. diesel fuel price remains stable

    U.S. Energy Information Administration (EIA) Indexed Site

    diesel fuel price remains stable The U.S. average retail price for on-highway diesel fuel remained unchanged from a week ago at $2.43 a gallon on Monday. That's based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the West Coast states at 2.71 a gallon, up 7-tenths of a penny from a week ago. Prices were lowest in the Gulf Coast states at 2.29 a gallon, down 1.1 cents. This is Amerine Woodyard

  5. United States Collaborates with Switzerland to Remove Last Remaining

    National Nuclear Security Administration (NNSA)

    Separated Plutonium | National Nuclear Security Administration | (NNSA) United States Collaborates with Switzerland to Remove Last Remaining Separated Plutonium March 03, 2016 (WASHINGTON, D.C.) - The Department of Energy's National Nuclear Security Administration (NNSA), working in collaboration with the Government of Switzerland, announced that approximately 20 kilograms of separated plutonium have been transported from Switzerland to the United States. The successful transport of this

  6. NNSA Partnership Successfully Removes All Remaining HEU from Uzbekistan |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Partnership Successfully Removes All Remaining HEU from Uzbekistan September 29, 2015 WASHINGTON, DC - Today, the Department of Energy's National Nuclear Security Administration (DOE/NNSA) announced the successful return of the final 5 kilograms (approximately 11 pounds) of highly enriched uranium (HEU) spent fuel from the IIN-3M "Foton" research reactor in Tashkent, Uzbekistan to Russia. This is the eighth shipment of HEU from

  7. Belarus ratifies START I pact; Ukraine remains last holdout

    SciTech Connect (OSTI)

    Lockwood, D.

    1993-03-01

    The Belarus Parliment ratified START I by a vote of 218 to 1 on February 4, 1993. The Parliment also voted to accede to the nuclear Non-Proliferation Treaty as a non-nuclear weapon state. The Parliment also passed two companion accords with Russia to coordinate the withdrawal of the ICBMs now in Belarus and to define the legal states of those weapons. Ukraine remains the only party to START I that has not yet approved the treaty.

  8. 43 CFR Part 10: Native American Graves Protection and Repatriation Regulations (1995, amended 2010)

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Native American Graves Protection and Repatriation Act was enacted on November 16, 1990, to address the rights of lineal descendants, Indian tribes, and Native Hawaiian organizations to Native American cultural items, including human remains, funerary objects, sacred objects, and objects of cultural patrimony.

  9. U.S. diesel fuel prices remain stable

    U.S. Energy Information Administration (EIA) Indexed Site

    diesel fuel prices remain stable The U.S. average retail price for on-highway diesel fuel fell 6-tenths of a penny to $2.12 a gallon on Monday. That's based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the West Coast states at 2.32 a gallon, up 2-tenths of a penny from a week ago. Prices were lowest in the Gulf Coast states at 1.98 a gallon, down 1.8 cents. This is Amerine Woodyard

  10. Oil and gas resources remaining in the Permian Basin

    SciTech Connect (OSTI)

    Not Available

    1989-01-01

    In this book the authors present a reevaluation of the oil and gas resource base remaining in existing Permian Basin reservoirs. The Permian Basin is one of the nation's premier sources of oil production, accounting for almost one quarter of the total domestic oil resource. The distribution and magnitude of oil and gas resources discovered in the basin are documented at the play and reservoir levels. Data on reservoir geology and volumetric analysis come from the oil and gas atlases published by the Bureau of Economic Geology, the Bureau's oil-reservoir data base, and NRG Associates Significant Oil and Gas Fields of the United States.

  11. Hydrogen effect on remaining life of hydroprocessing reactors

    SciTech Connect (OSTI)

    Iwadate, T.; Nomura, T.; Watanabe, J.

    1988-02-01

    Old vintage 2.25Cr-1Mo steels used for high-temperature/pressure hydroprocessing reactors have a high potential for temper embrittlement. The cracks caused by hydrogen embrittlement (HE) have been experienced in a stainless steel overlay and base metal of hydroprocessing reactors. In this paper, the temper embrittlement behavior during long-term service is discussed using the results of isothermal temper embrittlement tests up to 30,000 h of exposure. HE susceptibility of base metals, i.e., the threshold stress intensity factor K/sub IH/ and hydrogen-assisted crack growth rate behavior are also discussed. Based on the experimental data obtained, the remaining life assessment of a 2.25Cr-1Mo steel hydroprocessing reactor is analyzed from knowledge of HE.

  12. Microsoft Word - AL 2010-07 Acquistion Letters Remaining in Effect...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2010-07 Acquistion Letters Remaining in Effect May 2010 revision 1 June 2010 Microsoft Word - AL 2010-07 Acquistion Letters Remaining in Effect May 2010 revision 1 June 2010...

  13. UC 9-9-403 - Native American Remains | Open Energy Information

    Open Energy Info (EERE)

    9-403 - Native American Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-9-403 - Native American RemainsLegal...

  14. UC 9-9-405 - Native American Remains Review | Open Energy Information

    Open Energy Info (EERE)

    5 - Native American Remains Review Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-9-405 - Native American Remains...

  15. Current Size and Remaining Market Potential of the U.S. Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry ...

  16. Recommendation 215: Recommendation on Remaining Legacy Materials on the Oak Ridge Reservation

    Broader source: Energy.gov [DOE]

    The Oak Ridge Site Specific Advisory Board approved the enclosed recommendation on remaining legacy materials on the Oak Ridge Reservation.

  17. Current Size and Remaining Market Potential of the U.S. Energy Service

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Company Industry | Department of Energy Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry The study analyzes the size, growth and trends in the U.S. energy service company (ESCO) industry, drawing on information provided by industry executives and experts in 2012. The report also provides a preliminary estimate of remaining investment potential and annual blended

  18. Current Size and Remaining Market Potential of the U.S. Energy Service

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Company Industry | Department of Energy Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry "This report contains information on Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry, prepared for the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy, Weatherization and Intergovernmental Program."

  19. Analysis of long-term impacts of TRU waste remaining at generator/storage sites for No Action Alternative 2

    SciTech Connect (OSTI)

    Buck, J.W.; Bagaasen, L.M.; Bergeron, M.P.; Streile, G.P.

    1997-09-01

    This report is a supplement to the Waste Isolation Pilot Plant Disposal-Phase Final Supplemental Environmental Impact Statement (SEIS-II). Described herein are the underlying information, data, and assumptions used to estimate the long-term human-health impacts from exposure to radionuclides and hazardous chemicals in transuranic (TRU) waste remaining at major generator/storage sites after loss of institutional control under No Action Alternative 2. Under No Action Alternative 2, TRU wastes would not be emplaced at the Waste Isolation Pilot Plant (WIPP) but would remain at generator/storage sites in surface or near-surface storage. Waste generated at smaller sites would be consolidated at the major generator/storage sites. Current TRU waste management practices would continue, but newly generated waste would be treated to meet the WIPP waste acceptance criteria. For this alternative, institutional control was assumed to be lost 100 years after the end of the waste generation period, with exposure to radionuclides and hazardous chemicals in the TRU waste possible from direct intrusion and release to the surrounding environment. The potential human-health impacts from exposure to radionuclides and hazardous chemicals in TRU waste were analyzed for two different types of scenarios. Both analyses estimated site-specific, human-health impacts at seven major generator/storage sites: the Hanford Site (Hanford), Idaho National Engineering and Environmental Laboratory (INEEL), Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory (ORNL), Rocky Flats Environmental Technology Site (RFETS), and Savannah River Site (SRS). The analysis focused on these seven sites because 99 % of the estimated TRU waste volume and inventory would remain there under the assumptions of No Action Alternative 2.

  20. Severe Weather Update: JLab Remains in HPC-2 for Nor'easter ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Severe Weather Update: JLab Remains in HPC-2 for Nor'easter & Hurricane Jefferson Lab's Emergency Management Severe Weather Team continues monitoring the forecasts and conditions...

  1. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect (OSTI)

    Ryan, G.W., Westinghouse Hanford

    1996-07-12

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  2. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect (OSTI)

    Ryan, G.W., Westinghouse Hanford

    1996-09-19

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  3. Italy makes U-turn on nuclear power, but hurdles remain

    SciTech Connect (OSTI)

    2009-05-15

    A consortium consisting of ENEL and EDF in partnership with others including Edison, a major generator, and possibly a number of heavy industrial electricity users could invest in nuclear plants. But many technical, political, regulatory, and financial hurdles remain.

  4. White House: D'Agostino To Remain as NNSA Administrator | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy House: D'Agostino To Remain as NNSA Administrator White House: D'Agostino To Remain as NNSA Administrator September 3, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced that Thomas Paul D'Agostino, Under Secretary for Nuclear Security of the Department of Energy and Administrator for Nuclear Security of the National Nuclear Security Administration, will continue serving in his current role. The following is a quote from the President included in today's

  5. A National Forum on Demand Response: What Remains to Be Done to Achieve Its

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Potential | Department of Energy A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential In July 2011, the Federal Energy Regulatory Commission's (FERC) staff and the Department of Energy (DOE) jointly submitted to Congress a required "Implementation Proposal for the National Action Plan on Demand Response." The Implementation Proposal was for FERC's June 2010

  6. Energy Department Issues Remaining $1.8 Billion in Loan Guarantees for

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Vogtle Advanced Nuclear Energy Project | Department of Energy Issues Remaining $1.8 Billion in Loan Guarantees for Vogtle Advanced Nuclear Energy Project Energy Department Issues Remaining $1.8 Billion in Loan Guarantees for Vogtle Advanced Nuclear Energy Project June 24, 2015 - 9:20am Addthis NEWS MEDIA CONTACT (202) 586-4940 To further support the construction of two advanced nuclear reactors at the Alvin W. Vogtle Electric Generating Plant, the Department of Energy announced today it will

  7. WPN 10-5: Grantee Performance Required to Release the Hold on Remaining 50%

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Obligated Funds under the American Recovery and Reinvestment Act of 2009 | Department of Energy 0-5: Grantee Performance Required to Release the Hold on Remaining 50% of Obligated Funds under the American Recovery and Reinvestment Act of 2009 WPN 10-5: Grantee Performance Required to Release the Hold on Remaining 50% of Obligated Funds under the American Recovery and Reinvestment Act of 2009 Archived 09/30/15, ARRA Completion Provides guidance to Grantees under the Weatherization

  8. Natural gas inventories to remain high at end of winter heating season

    U.S. Energy Information Administration (EIA) Indexed Site

    Natural gas inventories to remain high at end of winter heating season Despite the jump in natural gas use to meet heating demand during the recent winter storm that walloped the East Coast, total U.S. natural gas inventories remain near 3 trillion cubic feet. That's about 20 percent higher than at this time last year. In its new monthly forecast, the U.S. Energy Information Administration said that by the end of the winter heating season at the close of March, it expects natural gas inventories

  9. Analysis of solids remaining following chemical cleaning in tank 6F

    SciTech Connect (OSTI)

    Poirier, Michael R.; Fondeur, Fernando F.; Missimer, David M.; Summer, Michael E.; Fink, Samuel D.

    2010-02-05

    Following chemical cleaning, a solid sample was collected and submitted to Savannah River National Laboratory (SRNL) for analysis. SRNL analyzed this sample by X-ray Diffraction (XRD) and scanning electron microscopy (SEM) to determine the composition of the solids remaining in Tank 6F and to assess the effectiveness of the chemical cleaning process.

  10. Evaluation of remaining life of the double-shell tank waste systems

    SciTech Connect (OSTI)

    Schwenk, E.B.

    1995-05-04

    A remaining life assessment of the DSTs (double-shell tanks) and their associated waste transfer lines, for continued operation over the next 10 years, was favorable. The DST assessment was based on definition of significant loads, evaluation of data for possible material degradation and geometric changes and evaluation of structural analyses. The piping assessment was based primarily on service experience.

  11. Grantee Performance Required to Release the Hold on Remaining 50% of Obligated Recovery Act Funds

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Weatherization Assistance Program Notice 10-05 deals with performance requirements for program grantees„states and U.S. territories„to receive the remaining 50% of obligated funds under the 2009 American Reinvestment and Recovery Act.

  12. Method and apparatus to predict the remaining service life of an operating system

    DOE Patents [OSTI]

    Greitzer, Frank L.; Kangas, Lars J.; Terrones, Kristine M.; Maynard, Melody A.; Pawlowski, Ronald A. , Ferryman; Thomas A.; Skorpik, James R.; Wilson, Bary W.

    2008-11-25

    A method and computer-based apparatus for monitoring the degradation of, predicting the remaining service life of, and/or planning maintenance for, an operating system are disclosed. Diagnostic information on degradation of the operating system is obtained through measurement of one or more performance characteristics by one or more sensors onboard and/or proximate the operating system. Though not required, it is preferred that the sensor data are validated to improve the accuracy and reliability of the service life predictions. The condition or degree of degradation of the operating system is presented to a user by way of one or more calculated, numeric degradation figures of merit that are trended against one or more independent variables using one or more mathematical techniques. Furthermore, more than one trendline and uncertainty interval may be generated for a given degradation figure of merit/independent variable data set. The trendline(s) and uncertainty interval(s) are subsequently compared to one or more degradation figure of merit thresholds to predict the remaining service life of the operating system. The present invention enables multiple mathematical approaches in determining which trendline(s) to use to provide the best estimate of the remaining service life.

  13. Prognostication of LED Remaining Useful Life and Color Stability in the Presence of Contamination

    SciTech Connect (OSTI)

    Lall, Pradeep; Zang, Hao; Davis, J Lynn

    2015-06-22

    The reliability of LED products may be affected by both luminous flux drop and color shift. Previous research on the topic focuses on either luminous maintenance or color shift. However, luminous flux degradation usually takes very long time to observe in LEDs under normal operating conditions. In this paper, the impact of a VOC (volatile organic compound) contaminated luminous flux and color stability are examined. As a result, both luminous degradation and color shift had been recorded in a short time. Test samples are white, phosphorconverted, high-power LED packages. Absolute radiant flux is measured with integrating sphere system to calculate the luminous flux. Luminous flux degradation and color shift distance were plotted versus aging time to show the degradation pattern. A prognostic health management (PHM) method based on the state variables and state estimator have been proposed in this paper. In this PHM framework, unscented kalman filter (UKF) was deployed as the carrier of all states. During the estimation process, third order dynamic transfer function was used to implement the PHM framework. Both of the luminous flux and color shift distance have been used as the state variable with the same PHM framework to exam the robustness of the method. Predicted remaining useful life is calculated at every measurement point to compare with the tested remaining useful life. The result shows that state estimator can be used as the method for the PHM of LED degradation with respect to both luminous flux and color shift distance. The prediction of remaining useful life of LED package, made by the states estimator and data driven approach, falls in the acceptable errorbounds (20%) after a short training of the estimator.

  14. Liquid ash corrosion, remaining life estimation and superheater/reheater replacement strategy in coal fired boilers

    SciTech Connect (OSTI)

    Alice, J.A.; Janiszewski, J.A.

    1985-01-01

    The liquid ash corrosion of superheater and reheater tubing in coal fired boilers is commonly accepted to be caused by the action of liquid sodium and potassium iron trisulfates Na/sub 3/Fe(SO/sub 4/) and K/sub 3/Fe(SO/sub 4/)/sub 3/. These species melt at temperatures between 1030/sup 0/F and 1160/sup 0/F (555-625/sup 0/C) depending on the relative amounts of sodium and potassium. Rapid tube wastage begins when the tube metal temperature reaches the trisulfate melting point. The key to improved availability in fossil boilers is to identify and replace, during a planned outage, tubes which are likely to fail before the next planned outage. The authors have developed a computerized method for estimating the remaining life of superheater/reheater tubes based on accelerated liquid ash corrosion. The scheme of analysis employs the following logic: (1) measurement of tube wastage from several removed samples, (2) estimation of tube metal temperature from I.D. scale thickness and thermocouple data, (3) estimation of trisulfate melting point from chemical analysis of the ash deposit and (4) using the computer model to calculate remaining life as a function of tube wastage rate metal temperature. The practical application of this strategy is presented for a coal fired boiler in the GPU system.

  15. Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Merlevede, Jane; Droin, Nathalie; Qin, Tingting; Meldi, Kristen; Yoshida, Kenichi; Morabito, Margot; Chautard, Emilie; Auboeuf, Didier; Fenaux, Pierre; Braun, Thorsten; et al

    2016-02-24

    The cytidine analogues azacytidine and 5-aza-2’-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a comprehensive analysis of the mutational landscape of these tumours, combining whole-exome and whole-genome sequencing. We identify an average of 14 ± 5 somatic mutations in coding sequences of sorted monocyte DNA and the signatures of three mutational processes. Serial sequencing demonstrates that the response to hypomethylating agents ismore » associated with changes in DNA methylation and gene expression, without any decrease in the mutation allele burden, nor prevention of new genetic alteration occurence. Lastly, our findings indicate that cytosine analogues restore a balanced haematopoiesis without decreasing the size of the mutated clone, arguing for a predominantly epigenetic effect.« less

  16. Neutron measurements of the fuel remaining in the TMI II once-through steam generators (OTSG'S)

    SciTech Connect (OSTI)

    Geelhood, B.D.; Abel, K.H.

    1989-02-01

    Polypropylene tubes containing a string of 18 copper rods were inserted into the lower head region and each J-leg of the two once-through steam generators (OTSG) of the unit two reactor at Three Mile Island. The object was to measure the neutron flux present in those regions and estimate the amount of residual fuel remaining in each OTSG. The neutron flux from any residual fuel induces a radioisotope, /sup 64/Cu, in the copper coupons. The /sup 64/Cu activity is detected by coincidence counting the two 511-keV gamma rays produced by the annihilation of the positron emitted in the decay of /sup 64/Cu. The copper coupons were placed between two 6-inch diameter, 6-inch long NaI(Tl) crystals and the electronics produced a coincidence count whenever the two gamma rays were uniquely detected. The net coincidence count is proportional to the amount of /sup 64/Cu activity in the coupon. This document discusses calculation methods, statistical methods, and results of this research. 3 figs., 30 tabs.

  17. An Integrated Site-Wide Assessment of Nuclear Wastes to Remain at the Hanford Site, Washington

    SciTech Connect (OSTI)

    Morse, J.G.; Bryce, R.W.; Hildebrand, R.D.; Kincaid, C.T.

    2004-10-06

    Since its creation in 1943 until 1988, the Hanford Site, a facility in the U.S. Department of Energy (DOE) nuclear weapons complex was dedicated to the production of weapons grade plutonium and other special nuclear materials. The Hanford Site is located in eastern Washington State and is bordered on the north and east by the Columbia River. Decades of creating fuel, irradiating it in reactors, and processing it to recover nuclear material left numerous waste sites that involved the discharge of contaminated liquids and the disposal of contaminated solid waste. Today, the primary mission of the Hanford Site is to safely cleanup and manage the site's legacy waste. A site-wide risk assessment methodology has been developed to assist the DOE, as well as state and federal regulatory agencies, in making decisions regarding needed remedial actions at past waste sites, and safe disposal of future wastes. The methodology, referred to as the System Assessment Capability (SAC), utilizes an integrated set of models that track potential contaminants from inventory through vadose zone, groundwater, Columbia River and air pathways to human and ecological receptors.

  18. Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants – Interim Study FY13

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Fifield, Leonard S.; Westman, Matthew P.; Ramuhalli, Pradeep; Pardini, Allan F.; Tedeschi, Jonathan R.; Jones, Anthony M.

    2013-09-27

    The most important criterion for cable performance is its ability to withstand a design-basis accident. With nearly 1000 km of power, control, instrumentation, and other cables typically found in an NPP, it would be a significant undertaking to inspect all of the cables. Degradation of the cable jacket, electrical insulation, and other cable components is a key issue that is likely to affect the ability of the currently installed cables to operate safely and reliably for another 20 to 40 years beyond the initial operating life. The development of one or more nondestructive evaluation (NDE) techniques and supporting models that could assist in determining the remaining life expectancy of cables or their current degradation state would be of significant interest. The ability to nondestructively determine material and electrical properties of cable jackets and insulation without disturbing the cables or connections has been deemed essential. Currently, the only technique accepted by industry to measure cable elasticity (the gold standard for determining cable insulation degradation) is the indentation measurement. All other NDE techniques are used to find flaws in the cable and do not provide information to determine the current health or life expectancy. There is no single NDE technique that can satisfy all of the requirements needed for making a life-expectancy determination, but a wide range of methods have been evaluated for use in NPPs as part of a continuous evaluation program. The commonly used methods are indentation and visual inspection, but these are only suitable for easily accessible cables. Several NDE methodologies using electrical techniques are in use today for flaw detection but there are none that can predict the life of a cable. There are, however, several physical and chemical ptoperty changes in cable insulation as a result of thermal and radiation damage. In principle, these properties may be targets for advanced NDE methods to provide early

  19. An overview of remaining life assessment methods for high temperature components operating in the power and petrochemical industries

    SciTech Connect (OSTI)

    Middleton, C.J.; Townsend, R.D.

    1998-12-31

    The capability to assess the secure remaining life of components operating in the creep range, thereby assuring integrity between inspection intervals, has become a major factor in the economic operation of power and petrochemical plant which has passed the original design life, frequently by a considerable margin. An overview is given of the nature of remaining life assessment and examples given of methods developed for headers, seam-welded pipe and fired heaters. The more common problems associated with weldments are also reviewed.

  20. Microsoft Word - AL 2010-07 Acquistion Letters Remaining in Effect May 2010 revision 1 June 2010

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    No. AL 2010-07 Rev. 1 Acquisition Regulation Date 06/01/2010 ACQUISITION LETTER This Acquisition Letter is issued under the authority of the DOE and NNSA Senior Procurement Executives. Acquisition Letters (AL) that remain in effect are identified below. All other previously issued ALs have been superseded by a formal rule-making, incorporated into other guidance, and/or canceled. * * * * * * * * * * * * * * * * ACQUISITION LETTERS REMAINING IN EFFECT NUMBER DATE SUBJECT 93-4 04/07/1993 Displaced

  1. Apparatus for determining past-service conditions and remaining life of thermal barrier coatings and components having such coatings

    DOE Patents [OSTI]

    Srivastava, Alok Mani; Setlur, Anant Achyut; Comanzo, Holly Ann; Devitt, John William; Ruud, James Anthony; Brewer, Luke Nathaniel

    2004-05-04

    An apparatus for determining past-service conditions and/or remaining useful life of a component of a combustion engine and/or a thermal barrier coating ("TBC") of the component comprises a radiation source that provides the exciting radiation to the TBC to excite a photoluminescent ("PL") material contained therein, a radiation detector for detecting radiation emitted by the PL material, and means for relating a characteristic of an emission spectrum of the PL material to the amount of a crystalline phase in the TBC, thereby inferring the past-service conditions or the remaining useful life of the component or the TBC.

  2. Implementation of Remaining Useful Lifetime Transformer Models in the Fleet-Wide Prognostic and Health Management Suite

    SciTech Connect (OSTI)

    Agarwal, Vivek; Lybeck, Nancy J.; Pham, Binh; Rusaw, Richard; Bickford, Randall

    2015-02-01

    Research and development efforts are required to address aging and reliability concerns of the existing fleet of nuclear power plants. As most plants continue to operate beyond the license life (i.e., towards 60 or 80 years), plant components are more likely to incur age-related degradation mechanisms. To assess and manage the health of aging plant assets across the nuclear industry, the Electric Power Research Institute has developed a web-based Fleet-Wide Prognostic and Health Management (FW-PHM) Suite for diagnosis and prognosis. FW-PHM is a set of web-based diagnostic and prognostic tools and databases, comprised of the Diagnostic Advisor, the Asset Fault Signature Database, the Remaining Useful Life Advisor, and the Remaining Useful Life Database, that serves as an integrated health monitoring architecture. The main focus of this paper is the implementation of prognostic models for generator step-up transformers in the FW-PHM Suite. One prognostic model discussed is based on the functional relationship between degree of polymerization, (the most commonly used metrics to assess the health of the winding insulation in a transformer) and furfural concentration in the insulating oil. The other model is based on thermal-induced degradation of the transformer insulation. By utilizing transformer loading information, established thermal models are used to estimate the hot spot temperature inside the transformer winding. Both models are implemented in the Remaining Useful Life Database of the FW-PHM Suite. The Remaining Useful Life Advisor utilizes the implemented prognostic models to estimate the remaining useful life of the paper winding insulation in the transformer based on actual oil testing and operational data.

  3. Remaining Sites Verification Package for 132-DR-1, 1608-DR Effluent Pumping Station, Waste Site Reclassification Form 2005-035

    SciTech Connect (OSTI)

    R. A. Carlson

    2005-09-22

    Radiological characterization, decommissioning and demolition of the 132-DR-1 site, 1608-DR Effluent Pumping Station was performed in 1987. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. Residual concentrations support future land uses that can be represented by a rural-residential scenario and pose no threat to groundwater or the Columbia River based on RESRAD modeling.

  4. Remaining Sites Verification Package for the 100-B-24 Spillway, Waste Site Reclassification Form 2006-051

    SciTech Connect (OSTI)

    L. M. Dittmer

    2006-09-18

    The 100-B-24 Spillway is a spillway that was designed to serve as an emergency discharge point for the 116-B-7 outfall in the event that the 100-B-15 river effluent pipelines were blocked, damaged, or undergoing maintenance. The site meets the remedial action objectives specified in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  5. Dependence of waterflood remaining oil saturation on relative permeability, capillary pressure, and reservoir parameters in mixed wet, turbidite sands

    SciTech Connect (OSTI)

    Hirasaki, G.J.

    1995-12-31

    The dependence of waterflood oil recovery on relative permeability, capillary pressure, and reservoir parameters was investigated by numerical simulation. The relative permeability and capillary pressure curves were based on laboratory measurements on unconsolidated sands and were evaluated for water-wet and mixed wet states. The reservoir model was a prototype turbidite sand with a range of thickness and permeability values. The economic oil recovery was based on an economic limit water cut of 50%. The remaining oil saturation in the swept region for the water-wet cases was close to the residual oil saturation. The remaining oil saturation of the mixed wet cases ranged from low values near the residual oil saturation to far above the residual oil saturation. It is dependent on the reservoir parameters that govern: (1) the vertical {open_quotes}film surface drainage{close_quotes} of oil by gravity, (2) accumulation of a high oil saturation and thus a high relative permeability under the cap rock, (3) updip migration of the oil that accumulated under the cap rock. The dependence on the reservoir parameters can be summarized by dimensionless groups. There is a dimensionless time for the vertical displacement of oil by gravity. The accumulation of a high oil saturation under the cap rock is dependent on the ratio of the capillary transition zone and the sand thickness. The updip migration is dependent on a combination of the gravity number and the end point mobility ratio.

  6. Human Resources | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources

  7. Remaining Sites Verification Package for the 100-F-54 Animal Farm Pastures, Waste Site Reclassification Form 2008-015

    SciTech Connect (OSTI)

    J. M. Capron

    2008-04-17

    The 100-F-54 waste site, part of the 100-FR-2 Operable Unit, is the soil associated with the former pastures for holding domestic farm animals used in experimental toxicology studies. Evaluation of historical information resulted in identification of the experimental animal farm pastures as having potential residual soil contamination due to excrement from experimental animals. The 100-F-54 animal farm pastures confirmatory sampling results support a reclassification of this site to No Action. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  8. Remaining Sites Verification Package for the 100-F-50 Stormwater Runoff Culvert, Waste Site Reclassification Form 2007-001

    SciTech Connect (OSTI)

    J. M. Capron

    2008-04-15

    The 100-F-50 waste site, part of the 100-FR-2 Operable Unit, is a steel stormwater runoff culvert that runs between two railroad grades in the south-central portion of the 100-F Area. The culvert exiting the west side of the railroad grade is mostly encased in concrete and surrounded by a concrete stormwater collection depression partially filled with soil and vegetation. The drain pipe exiting the east side of the railroad grade embankment is partially filled with soil and rocks. The 100-F-50 stormwater diversion culvert confirmatory sampling results support a reclassification of this site to no action. The current site conditions achieve the remedial action objectives and corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  9. Report for Westinghouse Hanford Company: Makeup procedures and characterization data for modified DSSF and modified remaining inventory simulated tank waste

    SciTech Connect (OSTI)

    Lokken, R.O.

    1996-03-01

    The majority of defense wastes generated from reprocessing spent reactor fuel at Hanford are stored in underground Double-Shell Tanks (DST) and in older Single-Shell Tanks (SST). The Tank Waste Remediation System (TWRS) Program has the responsibility of safely managing and immobilizing these tank wastes for disposal. A reference process flowsheet is being developed that includes waste retrieval, pretreatment, and vitrification. Melter technologies for vitrifying low-level tank wastes are being evaluated by Westinghouse Hanford Company. Chemical simulants are being used in the technology testing. For the first phase of low-level waste (LLW) vitrification simulant development, two waste stream compositions were investigated. The first waste simulant was based on the analyses of six tanks of double-shell slurry feed (DSSF) waste and on the projected composition of the wastes exiting the pretreatment operations. A simulant normalized to 6 M sodium was based on the anticipated chemical concentrations after ion exchange and initial separations. The same simulant concentrated to 10 M sodium would represent a waste that had been concentrated by evaporation to reduce the overall volume. The second LLW simulant, referred to as the remaining inventory (RI), included wastes not included in the DSSF tanks and the projected LLW fraction of single-shell tank wastes.

  10. Dependence of waterflood remaining oil saturation on relative permeability, capillary pressure, and reservoir parameters in mixed-wet turbidite sands

    SciTech Connect (OSTI)

    Hirasaki, G.J.

    1996-05-01

    The dependence of waterflood oil recovery on relative permeability, capillary pressure, and reservoir parameters was investigated by numerical simulation. The relative permeability and capillary pressure curves were based on laboratory measurements on unconsolidated sands. The water-wet case is based on the assumption that the system is water-wet and measurements were made with refined oil. The mixed-wet case assumed that the system is mixed-wet and restored-state measurements were made with crude oil. The reservoir model was a prototype turbidite sand with a range of thickness and permeability values. The economic oil recovery was based on an economic limit water cut of 50%. The remaining oil saturation (ROS) in the swept region for the water-wet cases was close to the residual oil saturation. The ROS of the mixed-wet cases ranged from low values near the residual oil saturation to far above the residual oil saturation. It is dependent on the reservoir parameters that govern (1) the vertical film surface drainage of oil by gravity, (2) accumulation of a high oil saturation and thus a high relative permeability under the caprock, and (3) up-dip migration of the oil that accumulated under the caprock. The dependence on the reservoir parameters can be summarized by dimensionless groups. There is a dimensionless time for the vertical displacement of oil by gravity. The accumulation of a high oil saturation under the caprock is dependent on the ratio of the capillary transition zone and the sand thickness. The updip migration is dependent on a combination of the gravity number and the endpoint mobility ratio.

  11. Acquisition Letters Remaining In Effect

    Office of Energy Efficiency and Renewable Energy (EERE)

    Acquisition Letter (AL) 2010-07 has been issued. It lists ALs currently in effect and the discontinued ALs along with the reason why the AL is no longer in effect.

  12. Acquisition Letters Remaining In Effect

    Office of Energy Efficiency and Renewable Energy (EERE)

    Acquisition Letter (AL) 2012-01 has been issued. It lists ALs currently in effect and the discontinued ALs, along with the reason why the AL is no longer in effect.

  13. Remaining Sites Verification Package for the 100-C-9:2 Sanitary Sewer Pipelines, Waste Site Reclassification Form 2004-013

    SciTech Connect (OSTI)

    L. M. Dittmer

    2007-07-11

    The 100-C-9:2 sanitary sewer pipelines include the feeder pipelines associated with the 1607-B8, the 1607-B9, the 1607-B10 and the 1607-B11 septic systems. Contaminated soil and piping from the feeder lines to the septic systems were removed and disposed of. The remaining soil in the excavations has been shown to meet the remedial action objectives specified in the Remaining Sites ROD. The results of verification sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  14. Human-mouse comparative genomics: successes and failures to reveal functional regions of the human genome

    SciTech Connect (OSTI)

    Pennacchio, Len A.; Baroukh, Nadine; Rubin, Edward M.

    2003-05-15

    Deciphering the genetic code embedded within the human genome remains a significant challenge despite the human genome consortium's recent success at defining its linear sequence (Lander et al. 2001; Venter et al. 2001). While useful strategies exist to identify a large percentage of protein encoding regions, efforts to accurately define functional sequences in the remaining {approx}97 percent of the genome lag. Our primary interest has been to utilize the evolutionary relationship and the universal nature of genomic sequence information in vertebrates to reveal functional elements in the human genome. This has been achieved through the combined use of vertebrate comparative genomics to pinpoint highly conserved sequences as candidates for biological activity and transgenic mouse studies to address the functionality of defined human DNA fragments. Accordingly, we describe strategies and insights into functional sequences in the human genome through the use of comparative genomics coupled wit h functional studies in the mouse.

  15. Phased Construction Completion Report for Bldg. K-1401 of the Remaining Facilities Demolition Project at the East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Bechtel Jacobs

    2008-10-01

    This Phased Construction Completion Report documents the demolition of Bldg. K-1401, Maintenance Building, addressed in the Action Memorandum for the Remaining Facilities Demolition Project at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE 2003a) as a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 non-time-critical removal action. The objectives of the removal action (DOE 2003a) - to eliminate the source of potential contamination, to eliminate the threat of potential future releases, and/or to eliminate the threats to the general public and the environment - were met. The end state of this action is for the slab to remain with all penetrations sealed and grouted or backfilled. The basement and pits remain open. There is residual radiological and polychlorinated biphenyl contamination on the slab and basement. A fixative was applied to the area on the pad contaminated with polychlorinated biphenyls. Interim land-use controls will be maintained until final remediation decisions are made under the Zone 2 Record of Decision (DOE 2005a).

  16. Phased Construction Completion Report for Building K-1401 of the Remaining Facilities Demolition Project at the East Tennessee Technology Park Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Garland S.

    2008-03-01

    This Phased Construction Completion Report documents the demolition of Bldg. K-1401, Maintenance Building, addressed in the Action Memorandum for the Remaining Facilities Demolition Project at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE 2003a) as a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 non-time-critical removal action. The objectives of the removal action (DOE 2003a) - to eliminate the source of potential contamination, to eliminate the threat of potential future releases, and/or to eliminate the threats to the general public and the environment - were met. The end state of this action is for the slab to remain with all penetrations sealed and grouted or backfilled. The basement and pits remain open. There is residual radiological and polychlorinated biphenyl contamination on the slab and basement. A fixative was applied to the area on the pad contaminated with polychlorinated biphenyls. Interim land-use controls will be maintained until final remediation decisions are made under the Zone 2 Record of Decision (DOE 2005a).

  17. Remaining Sites Verification Package for the 100-B-1 Surface Chemical and Solid Waste Dumping Area, Waste Site Reclassification Form 2006-003

    SciTech Connect (OSTI)

    R. A. Carlson

    2006-04-24

    The 100-B-1 waste site was a dumping site that was divided into two areas. One area was used as a laydown area for construction materials, and the other area was used as a chemical dumping area. The 100-B-1 Surface Chemical and Solid Waste Dumping Area site meets the remedial action objectives specified in the Remaining Sites ROD. The results demonstrate that residual contaminant concentrations support future unrestricted land uses that can be represented by a rural-residential scenario. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  18. ORISE: Protecting Human Subjects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Protecting Human Subjects The U.S. Department of Energy (DOE) Human Subjects Research Program exists to ensure that all research conducted at DOE ...

  19. Human Resources Specialist (Human Resources Development)

    Broader source: Energy.gov [DOE]

    This position is located in the Leadership and Organizational Development group of Learning and Development (NHT), Human Capital Management (NH), Chief Administrative Officer (N). Human Capital...

  20. Remaining Sites Verification Package for the 100-F-44:2, Discovery Pipeline Near 108-F Building, Waste Site Reclassification Form 2007-006

    SciTech Connect (OSTI)

    J. M. Capron

    2008-05-30

    The 100-F-44:2 waste site is a steel pipeline that was discovered in a junction box during confirmatory sampling of the 100-F-26:4 pipeline from December 2004 through January 2005. The 100-F-44:2 pipeline feeds into the 100-F-26:4 subsite vitrified clay pipe (VCP) process sewer pipeline from the 108-F Biology Laboratory at the junction box. In accordance with this evaluation, the confirmatory sampling results support a reclassification of this site to No Action. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  1. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Ramuhalli, Pradeep; Brenchley, David L.; Coble, Jamie B.; Hashemian, Hash; Konnik, Robert; Ray, Sheila

    2012-09-14

    The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), NDE instrumentation development, universities, commercial NDE services and cable manufacturers, and Electric Power Research Institute (EPRI). The motivation for the R&D roadmap comes from the need to address the aging management of in-containment cables at nuclear power plants (NPPs).

  2. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, K.L.; Ramuhali, P.; Brenchley, D.L.; Coble, J.B.; Hashemian, H.M.; Konnick, R.; Ray, S.

    2012-09-01

    Executive Summary [partial] The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. A workshop was held to gather subject matter experts to develop the NDE R&D Roadmap for Cables. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, and NDE instrumentation development from the U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), universities, commercial NDE service vendors and cable manufacturers, and the Electric Power Research Institute (EPRI).

  3. Remaining Sites Verification Package for the 100-D-9 Boiler Fuel Oil Tank Site, Waste Site Reclassification Form 2006-030

    SciTech Connect (OSTI)

    L. M. Dittmer

    2006-08-10

    The 100-D-9 site is the former location of an underground storage tank used for holding fuel for the 184-DA Boiler House. Results of soil-gas samples taken from six soil-gas probes in a rectangle around the site the tank had been removed from concluded that there were no volatile organic compounds at detectable levels in the area. The 100-D-9 Boiler Fuel Oil Tank Site meets the remedial action objectives specified in the Remaining Sites ROD. The results demonstrated that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  4. An evaluation of known remaining oil resources in the state of California: Project on advanced oil recovery and the states. Volume 2

    SciTech Connect (OSTI)

    1993-11-01

    The Interstate Oil and Gas Compact Commission (IOGCC) has conducted a series of studies to evaluate the known, remaining oil resource in twenty-three (23) states. The primary objective of die IOGCC`s effort is to examine the potential impact of an aggressive and focused program of research, development, and demonstration (RD&D) and technology transfer on future oil recovery in the United States. As part of a larger effort by the IOGCC, this report focuses on the potential economic benefits of improved oil recovery in the state of California. Individual reports for seven other oil producing states and a national report have been separately published by the IOGCC. Several major technical insights for state and Federal policymakers and regulators can be reached from this analysis. Overall, well abandonments and more stringent environmental regulations could limit economic access to the nation`s known, remaining oil resource. The high risk of near-term abandonment and the significant benefits of future application of improved oil recovery technoloy, clearly point to a need for more aggressive transfer of currently available technologies to domestic oil producers. Development and application of advanced oil recovery technologies could leave even greater benefits to the nation. A collaborative, focused RD&D effort, integrating the resources and expertise of industry, state and local governments, and the Federal government, is clearly warranted. With effective RD&D and a program of aggressive technology transfer to widely disseminate its results, California oil production could be maximized. The resulting increase and improvement in production rates, employment, operator profits, state and Federal tax revenues, energy security will benefit both the state of California and the nation as a whole.

  5. An evaluation of known remaining oil resources in the state of California. Volume 2, Project on Advanced Oil Recovery and the States

    SciTech Connect (OSTI)

    Not Available

    1994-10-01

    The Interstate Oil and Gas Compact Commission (IOGCC) has conducted a series of studies to evaluate the known, remaining oil resource in twenty-three (23) states. The primary objective of the IOGCC`s effort is to examine the potential impact of an aggressive and focused program of research, development, and demonstration (RD&D) and technology transfer on future oil recovery in the United States. As a part of this larger effort by the IOGCC, this report focuses on the potential economic benefits of improved oil recovery in the state of California. Individual reports for seven other oil producing states and a national report have been separately published by the IOGCC. The analysis presented in this report is based on the databases and models available in the Tertiary Oil Recovery Information System (TORIS). Overall, well abandonments and more stringent environmental regulations could limit economic access to California`s known, remaining oil resource. The high risk of near-term abandonment and the significant benefits of future application of improved oil recovery technology, clearly point to a need for more aggressive transfer of currently available technologies to oil producers. Development and application of advanced oil recovery technologies could have even greater benefits to the state and the nation. A collaborative, focused RD&D effort, integrating the resources and expertise of industry, state and local governments, and the Federal government, is clearly warranted. With effective RD&D and a program of aggressive technology transfer to widely disseminate its results, California oil production could be maximized. The resulting increase in production rates, employment, operator profits, state and Federal tax revenues, and energy security will benefit both the state of California and the nation as a whole.

  6. The mapping and differentiation of biological and environmental elemental signatures in the fossil remains of a 50 million year old bird

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Egerton, Victoria M.; Wogelius, Roy A.; Norell, Mark A.; Edwards, Nicholas P.; Sellers, William I.; Bergmann, Uwe; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Ignatyev, Konstantin; van Veelen, Arjen; et al

    2015-01-22

    The preservation of fossils reflects the interplay of inorganic and organic chemical processes, which should be clearly differentiated to make interpretations about the biology of extinct organisms. A new coliiformes bird (mouse bird) from the ~50 million year old Green River Formation (Wyoming, USA) has here been analysed using synchrotron X-ray fluorescence and environmental scanning electron microscopy with an attached X-ray energy dispersive system (ESEM-EDS). The concentration and distribution of 16 elements (Si, P, S, Cl, K, Ca, Ti, Mg, Fe, Ni, Cu, Zn, As, Br, Ba, Hg) has been mapped for individual points on the sample. S, Cu andmore » Zn map distinctly within visibly preserved feathers and X-ray Absorption Spectroscopy (XAS) shows that S and Cu within the feathers are organically bound in a similar manner to modern feathers. The morphological preservation of the feathers, on both macro- and microscopic scales, is variable throughout the fossil and the differences in the lateral microfacies have resulted in a morphological preservation gradient. This study clearly differentiates endogenous organic remains from those representing exogenous overprinted geochemical precipitates and illustrates the chemical complexity of the overall taphonomic process.« less

  7. The mapping and differentiation of biological and environmental elemental signatures in the fossil remains of a 50 million year old bird

    SciTech Connect (OSTI)

    Egerton, Victoria M.; Wogelius, Roy A.; Norell, Mark A.; Edwards, Nicholas P.; Sellers, William I.; Bergmann, Uwe; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Ignatyev, Konstantin; van Veelen, Arjen; Anné, Jennifer; van Dongen, Bart; Knoll, Fabien; Manning, Phillip L.

    2015-01-22

    The preservation of fossils reflects the interplay of inorganic and organic chemical processes, which should be clearly differentiated to make interpretations about the biology of extinct organisms. A new coliiformes bird (mouse bird) from the ~50 million year old Green River Formation (Wyoming, USA) has here been analysed using synchrotron X-ray fluorescence and environmental scanning electron microscopy with an attached X-ray energy dispersive system (ESEM-EDS). The concentration and distribution of 16 elements (Si, P, S, Cl, K, Ca, Ti, Mg, Fe, Ni, Cu, Zn, As, Br, Ba, Hg) has been mapped for individual points on the sample. S, Cu and Zn map distinctly within visibly preserved feathers and X-ray Absorption Spectroscopy (XAS) shows that S and Cu within the feathers are organically bound in a similar manner to modern feathers. The morphological preservation of the feathers, on both macro- and microscopic scales, is variable throughout the fossil and the differences in the lateral microfacies have resulted in a morphological preservation gradient. This study clearly differentiates endogenous organic remains from those representing exogenous overprinted geochemical precipitates and illustrates the chemical complexity of the overall taphonomic process.

  8. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

    SciTech Connect (OSTI)

    OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

    2000-07-30

    The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

  9. Human-machine interactions

    DOE Patents [OSTI]

    Forsythe, J. Chris; Xavier, Patrick G.; Abbott, Robert G.; Brannon, Nathan G.; Bernard, Michael L.; Speed, Ann E.

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  10. ORISE: Human Subjects Protection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) ... U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. ...

  11. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The Human Resources team is fully integrated with Jefferson Lab's mission, committed to providing quality customer service based on expertise, innovation and ...

  12. Human Reliability Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Signup SlideShare Human Reliability Assessment HomeStationary PowerNuclear EnergyNuclear Energy Safety TechnologiesRisk and Safety AssessmentHuman Reliability Assessment ...

  13. Task Decomposition in Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Joe, Jeffrey Clark

    2014-06-01

    In the probabilistic safety assessments (PSAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question remains central as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PSAs tend to be top-down— defined as a subset of the PSA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) are more likely to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications.

  14. ARM - Human Causes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Human Causes Some of the human activities which can cause ...

  15. Human Genome: DOE Origins

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Genome Research: DOE Origins Resources with Additional Information Charles DeLisi Charles DeLisi The genesis of the Department of Energy (DOE) human genome project took place ...

  16. Geothermal developers remain optimistic | Department of Energy

    Energy Savers [EERE]

    conventional fossil fuel generation closer to or above the ... Hurdles such as capital intensive technology also will need ... the primary energy supply mix of the U.S. For U.S. ...

  17. Remaining Barriers to LED Street Lighting

    Energy Savers [EERE]

    ownership, involving multiple decision-makers * Utilities own 60-70% of street lighting inventory in U.S. * Sometimes more than one utility present in a given metro area * Often...

  18. Report: EM Human Capital Initiatives

    Office of Environmental Management (EM)

    HUMAN CAPITAL September 25, 2008 Submitted by the EMAB Human Capital Subcommittee Background: The enhancement of the Office of Environmental Management's (EM) human capital has ...

  19. Corporate Human Resources Information Services (CHIRS) PIA, Office of Human

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Capitol Management | Department of Energy Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management (80.67 KB) More Documents & Publications MOX Services Unclassified

  20. Using populations of human and microbial genomes for organism detection in metagenomes

    SciTech Connect (OSTI)

    Ames, Sasha K.; Gardner, Shea N.; Marti, Jose Manuel; Slezak, Tom R.; Gokhale, Maya B.; Allen, Jonathan E.

    2015-04-29

    Identifying causative disease agents in human patients from shotgun metagenomic sequencing (SMS) presents a powerful tool to apply when other targeted diagnostics fail. Numerous technical challenges remain, however, before SMS can move beyond the role of research tool. Accurately separating the known and unknown organism content remains difficult, particularly when SMS is applied as a last resort. The true amount of human DNA that remains in a sample after screening against the human reference genome and filtering nonbiological components left from library preparation has previously been underreported. In this study, we create the most comprehensive collection of microbial and reference-free human genetic variation available in a database optimized for efficient metagenomic search by extracting sequences from GenBank and the 1000 Genomes Project. The results reveal new human sequences found in individual Human Microbiome Project (HMP) samples. Individual samples contain up to 95% human sequence, and 4% of the individual HMP samples contain 10% or more human reads. In conclusion, left unidentified, human reads can complicate and slow down further analysis and lead to inaccurately labeled microbial taxa and ultimately lead to privacy concerns as more human genome data is collected.

  1. Using populations of human and microbial genomes for organism detection in metagenomes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ames, Sasha K.; Gardner, Shea N.; Marti, Jose Manuel; Slezak, Tom R.; Gokhale, Maya B.; Allen, Jonathan E.

    2015-04-29

    Identifying causative disease agents in human patients from shotgun metagenomic sequencing (SMS) presents a powerful tool to apply when other targeted diagnostics fail. Numerous technical challenges remain, however, before SMS can move beyond the role of research tool. Accurately separating the known and unknown organism content remains difficult, particularly when SMS is applied as a last resort. The true amount of human DNA that remains in a sample after screening against the human reference genome and filtering nonbiological components left from library preparation has previously been underreported. In this study, we create the most comprehensive collection of microbial and reference-freemore » human genetic variation available in a database optimized for efficient metagenomic search by extracting sequences from GenBank and the 1000 Genomes Project. The results reveal new human sequences found in individual Human Microbiome Project (HMP) samples. Individual samples contain up to 95% human sequence, and 4% of the individual HMP samples contain 10% or more human reads. In conclusion, left unidentified, human reads can complicate and slow down further analysis and lead to inaccurately labeled microbial taxa and ultimately lead to privacy concerns as more human genome data is collected.« less

  2. Human Genome: DOE Origins

    Office of Scientific and Technical Information (OSTI)

    of the Department of Energy; DOE Technical Report; 1988 Mapping and Sequencing the Human Genome; DOE Technical Report; 1988 Understanding our Genetic Inheritance: The U.S....

  3. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Sponsor click on this link to nominate a student: SPONSOR NOMINATION FORM If you have any questions please contact: Human Resources Jefferson Science Associates 628 Hofstadter Rd., ...

  4. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JLab Diversity Policies 200 Human Resources 202 Equal Employment Opportunity and Affirmative Action 203 Employment 208 Employee Performance and Conduct 209 Staff Development 210 ...

  5. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Consultants Cassandra Andrews, HR Consultant, Employee Relations & Recruitment (757) 269-7068, candrews@jlab.org Kelly Allmon, HR Consultant, Recruitment & ...

  6. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

  7. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

  8. The human genome project

    SciTech Connect (OSTI)

    Yager, T.D.; Zewert, T.E.; Hood, L.E. )

    1994-04-01

    The Human Genome Project (HGP) is a coordinated worldwide effort to precisely map the human genome and the genomes of selected model organisms. The first explicit proposal for this project dates from 1985 although its foundations (both conceptual and technological) can be traced back many years in genetics, molecular biology, and biotechnology. The HGP has matured rapidly and is producing results of great significance.

  9. Human Genome Project

    SciTech Connect (OSTI)

    Block, S.; Cornwall, J.; Dally, W.; Dyson, F.; Fortson, N.; Joyce, G.; Kimble, H. J.; Lewis, N.; Max, C.; Prince, T.; Schwitters, R.; Weinberger, P.; Woodin, W. H.

    1998-01-04

    The study reviews Department of Energy supported aspects of the United States Human Genome Project, the joint National Institutes of Health/Department of Energy program to characterize all human genetic material, to discover the set of human genes, and to render them accessible for further biological study. The study concentrates on issues of technology, quality assurance/control, and informatics relevant to current effort on the genome project and needs beyond it. Recommendations are presented on areas of the genome program that are of particular interest to and supported by the Department of Energy.

  10. Human Reliability Program Overview

    SciTech Connect (OSTI)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  11. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

  12. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

  13. Human Resource Management Delegation

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-06-28

    The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

  14. Lessons Learned Concerning the Human Element in Events and Training

    SciTech Connect (OSTI)

    Michael D. Sandvig

    2006-02-01

    As the number and complexity of responses to hazardous material incidents have increased, government regulators have implemented a national incident command system, bolstered by a host of protective measures and response equipment. Special advanced technical equipment has also been developed and made available to on-scene responders and command staff. Yet with all the investment in organizational and technical advance, the human element of emergency response remains critical and also needs our continued attention to ensure effective operation and success. This paper focuses on lessons learned from radiological events and training exercises that pertain to these human elements.

  15. Fifty Years of THERP and Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring

    2012-06-01

    In 1962 at a Human Factors Society symposium, Alan Swain presented a paper introducing a Technique for Human Error Rate Prediction (THERP). This was followed in 1963 by a Sandia Laboratories monograph outlining basic human error quantification using THERP and, in 1964, by a special journal edition of Human Factors on quantification of human performance. Throughout the 1960s, Swain and his colleagues focused on collecting human performance data for the Sandia Human Error Rate Bank (SHERB), primarily in connection with supporting the reliability of nuclear weapons assembly in the US. In 1969, Swain met with Jens Rasmussen of Risø National Laboratory and discussed the applicability of THERP to nuclear power applications. By 1975, in WASH-1400, Swain had articulated the use of THERP for nuclear power applications, and the approach was finalized in the watershed publication of the NUREG/CR-1278 in 1983. THERP is now 50 years old, and remains the most well known and most widely used HRA method. In this paper, the author discusses the history of THERP, based on published reports and personal communication and interviews with Swain. The author also outlines the significance of THERP. The foundations of human reliability analysis are found in THERP: human failure events, task analysis, performance shaping factors, human error probabilities, dependence, event trees, recovery, and pre- and post-initiating events were all introduced in THERP. While THERP is not without its detractors, and it is showing signs of its age in the face of newer technological applications, the longevity of THERP is a testament of its tremendous significance. THERP started the field of human reliability analysis. This paper concludes with a discussion of THERP in the context of newer methods, which can be seen as extensions of or departures from Swain’s pioneering work.

  16. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that ...

  17. Human Resources | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The mission of the Human Resource Department is to support the goals of The Ames Laboratory by providing support services which promote a work environmnent ...

  18. Human Genome Research: Decoding DNA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Genome Research: Decoding DNA Resources with Additional Information Charles DeLisi ... role in proposing and initiating the Human Genome Program in 1986. The U.S. ...

  19. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations ... on all research projects that involve human subjects and that are funded by DOE, ...

  20. New light on human evolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    light on human evolution New light on human evolution Scientists recently unearthed 8 million-year-old gorilla fossils from the Chorora Formation in Ethiopia, which indicate the ...

  1. EVALUATION OF ACTIVATION PRODUCTS IN REMAINING IN REMAINING K-, L- AND C-REACTOR STRUCTURES

    SciTech Connect (OSTI)

    Vinson, D.; Webb, R.

    2010-09-30

    An analytic model and calculational methodology was previously developed for P-reactor and R-reactor to quantify the radioisotopes present in Savannah River Site (SRS) reactor tanks and the surrounding structural materials as a result of neutron activation of the materials during reactor operation. That methodology has been extended to K-reactor, L-reactor, and C-reactor. The analysis was performed to provide a best-estimate source term input to the Performance Assessment for an in-situ disposition strategy by Site Decommissioning and Demolition (SDD). The reactor structure model developed earlier for the P-reactor and R-reactor analyses was also used for the K-reactor and L-reactor. The model was suitably modified to handle the larger Creactor tank and associated structures. For all reactors, the structure model consisted of 3 annular zones, homogenized by the amount of structural materials in the zone, and 5 horizontal layers. The curie content on an individual radioisotope basis and total basis for each of the regions was determined. A summary of these results are provided herein. The efficacy of this methodology to accurately predict the radioisotopic content of the reactor systems in question has been demonstrated and is documented in Reference 1. As noted in that report, results for one reactor facility cannot be directly extrapolated to other SRS reactors.

  2. Human Capital - DOE Directives, Delegations, and Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Capital by Website Administrator Back

  3. Finishing The Euchromatic Sequence Of The Human Genome

    SciTech Connect (OSTI)

    Rubin, Edward M.; Lucas, Susan; Richardson, Paul; Rokhsar, Daniel; Pennacchio, Len

    2004-09-07

    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process.The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers {approx}99% of the euchromatic genome and is accurate to an error rate of {approx}1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number,birth and death. Notably, the human genome seems to encode only20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead.

  4. Human MSH2 protein

    DOE Patents [OSTI]

    Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

    1997-01-07

    The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

  5. Human MSH2 protein

    DOE Patents [OSTI]

    de la Chapelle, Albert; Vogelstein, Bert; Kinzler, Kenneth W.

    1997-01-01

    The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

  6. Human Resources | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Budget Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the Service Center's Office of Human Capital Management Services. The Headquarters' Office of Human Capital Management Programs is organized into the following five divisions. Policy and Planning The Policy and Planning Division will be responsible for the development, implementation, and oversight of, human resources management

  7. Human Reliability Program Handbook

    Broader source: Energy.gov [DOE]

    The Human Reliability Program is a security and safety reliability program designed to ensure that individuals who occupy positions affording access to certain materials, nuclear explosive devices, facilities, and programs meet the highest standards of reliability and physical and mental suitability.

  8. UPDATING THE NRC GUIDANCE FOR HUMAN FACTORS ENGINEERING REVIEWS.

    SciTech Connect (OSTI)

    O HARA,J.M.; BROWN,W.S.; HIGGINS,J.C.; PERSENSKY,J.J.; LEWIS,P.M.; BONGARRA,J.

    2002-09-15

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) aspects of nuclear plants. NUREG-0800 (Standard Review Plan), Chapter 18, ''Human Factors Engineering,'' is the principal NRC staff guidance document. Two main documents provide the review criteria to support the evaluations. The HFE Program Review Model (NUREG-0711) addresses the design process from planning to verification and validation to design implementation. The Human-System Interface Design Review Guidelines (NUREG-0700) provides the guidelines for the review of the HFE aspects of human-system interface technology, such as alarms, information systems, controls, and control room design. Since these documents were published in 1994 and 1996 respectively, they have been used by NRC staff, contractors, nuclear industry organizations, as well as by numerous organizations outside the nuclear industry. Using feedback from users and NRC research conducted in recent years, both documents have been revised and updated. This was done to ensure that they remain state-of-the-art evaluation tools for changing nuclear industry issues and emerging technologies. This paper describes the methodology used to revise and update the documents and summarizes the changes made to each and their current contents. Index Terms for this report are: Control system human factors, Ergonomics, Human factors, Nuclear power generation safety.

  9. Hyaluronan in human malignancies

    SciTech Connect (OSTI)

    Sironen, R.K.; Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio ; Tammi, M.; Tammi, R.; Auvinen, P.K.; Anttila, M.; Department of Gynecology and Obstetrics, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio ; Kosma, V-M.

    2011-02-15

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  10. Human Factors Engineering Analysis Tool

    Energy Science and Technology Software Center (OSTI)

    2002-03-04

    HFE-AT is a human factors engineering (HFE) software analysis tool (AT) for human-system interface design of process control systems, and is based primarily on NUREG-0700 guidance.

  11. Global Warming and Human Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Geophysical Union Global Warming and Human Health WHEN: Jul 27, 2015 5:30 PM - ... Event Description The main reason we are concerned about human-induced climate change is ...

  12. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that risks to human subjects in research are minimal and to provide protection with respect to the rights and welfare of research subjects. The Oak Ridge Institute for Science and Education (ORISE) administers the Oak Ridge Sitewide Institutional Review Board (ORSIRB) and manages the ORISE Human Subjects website. The

  13. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-03-17

    The Order establishes DOE-specific policy and principles for the protection of human subjects involved in DOE research, and DOE procedures and responsibilities for implementing the policy and requirements set forth in Title 45 Code of Federal Regulations (CFR) Part 46, Protection of Human Subjects, and 10 CFR Part 745, Protection of Human Subjects. Supersedes DOE O 443.1B.

  14. Human Capital Management Accountability Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-01

    The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

  15. Human portable preconcentrator system

    DOE Patents [OSTI]

    Linker, Kevin L.; Bouchier, Francis A.; Hannum, David W.; Rhykerd, Jr., Charles L.

    2003-01-01

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated.

  16. HUMAN MACHINE COOPERATIVE TELEROBOTICS

    SciTech Connect (OSTI)

    William R. Hamel; Spivey Douglass; Sewoong Kim; Pamela Murray; Yang Shou; Sriram Sridharan; Ge Zhang; Scott Thayer; Rajiv V. Dubey

    2003-06-30

    The remediation and deactivation and decommissioning (D&D) of nuclear waste storage tanks using telerobotics is one of the most challenging tasks faced in environmental cleanup. Since a number of tanks have reached the end of their design life and some of them have leaks, the unstructured, uncertain and radioactive environment makes the work inefficient and expensive. However, the execution time of teleoperation consumes ten to hundred times that of direct contact with an associated loss in quality. Thus, a considerable effort has been expended to improve the quality and efficiency of telerobotics by incorporating into teleoperation and robotic control functions such as planning, trajectory generation, vision, and 3-D modeling. One example is the Robot Task Space Analyzer (RTSA), which has been developed at the Robotics and Electromechanical Systems Laboratory (REMSL) at the University of Tennessee in support of the D&D robotic work at the Oak Ridge National Laboratory and the National Energy Technology Laboratory. This system builds 3-D models of the area of interest in task space through automatic image processing and/or human interactive manual modeling. The RTSA generates a task plan file, which describes the execution of a task including manipulator and tooling motions. The high level controller of the manipulator interprets the task plan file and executes the task automatically. Thus, if the environment is not highly unstructured, a tooling task, which interacts with environment, will be executed in the autonomous mode. Therefore, the RTSA not only increases the system efficiency, but also improves the system reliability because the operator will act as backstop for safe operation after the 3-D models and task plan files are generated. However, unstructured conditions of environment and tasks necessitate that the telerobot operates in the teleoperation mode for successful execution of task. The inefficiency in the teleoperation mode led to the research

  17. Human Genome Program

    SciTech Connect (OSTI)

    Not Available

    1993-01-01

    The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

  18. PIA - Human Resources Information System (HRIS) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Information System (HRIS) PIA - Human Resources Information System (HRIS) (232.73 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human ...

  19. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Project ATHENA creates surrogate human organ systems The development of miniature surrogate human organs, coupled with highly ...

  20. Contractor Human Resources | National Nuclear Security Administration...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contractor Human Resources The Contractor Human Resources mission is to provide expert advice and assistance to our customers in order to ensure quality Contractor Human Resource ...

  1. New human resources division leader selected

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Human Resources division leader selected New human resources division leader selected Donna J. Hampton has been named the new Human Resources Division leader. March 15, 2011 ...

  2. ORISE: Human Subjects Protection Resource Protection Book

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection Resource Book The Human Subjects Protection Resource Book synthesizes information currently available on the protection of human subjects in research, the ...

  3. Predicting Tissue-Specific Enhancers in the Human Genome

    SciTech Connect (OSTI)

    Pennacchio, Len A.; Loots, Gabriela G.; Nobrega, Marcelo A.; Ovcharenko, Ivan

    2006-07-01

    Determining how transcriptional regulatory signals areencoded in vertebrate genomes is essential for understanding the originsof multi-cellular complexity; yet the genetic code of vertebrate generegulation remains poorly understood. In an attempt to elucidate thiscode, we synergistically combined genome-wide gene expression profiling,vertebrate genome comparisons, and transcription factor binding siteanalysis to define sequence signatures characteristic of candidatetissue-specific enhancers in the human genome. We applied this strategyto microarray-based gene expression profiles from 79 human tissues andidentified 7,187 candidate enhancers that defined their flanking geneexpression, the majority of which were located outside of knownpromoters. We cross-validated this method for its ability to de novopredict tissue-specific gene expression and confirmed its reliability in57 of the 79 available human tissues, with an average precision inenhancer recognition ranging from 32 percent to 63 percent, and asensitivity of 47 percent. We used the sequence signatures identified bythis approach to assign tissue-specific predictions to ~;328,000human-mouse conserved noncoding elements in the human genome. Byoverlapping these genome-wide predictions with a large in vivo dataset ofenhancers validated in transgenic mice, we confirmed our results with a28 percent sensitivity and 50 percent precision. These results indicatethe power of combining complementary genomic datasets as an initialcomputational foray into the global view of tissue-specific generegulation in vertebrates.

  4. Human subjects research handbook: Protecting human research subjects. Second edition

    SciTech Connect (OSTI)

    1996-01-30

    This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

  5. Human portable preconcentrator system

    SciTech Connect (OSTI)

    Linker, Kevin L.; Brusseau, Charles A.; Hannum, David W.; Puissant, James G.; Varley, Nathan R.

    2003-08-12

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated. The screen can be positioned directly in front of the detector prior to heating to improve detection capability.

  6. Human-computer interface

    DOE Patents [OSTI]

    Anderson, Thomas G.

    2004-12-21

    The present invention provides a method of human-computer interfacing. Force feedback allows intuitive navigation and control near a boundary between regions in a computer-represented space. For example, the method allows a user to interact with a virtual craft, then push through the windshield of the craft to interact with the virtual world surrounding the craft. As another example, the method allows a user to feel transitions between different control domains of a computer representation of a space. The method can provide for force feedback that increases as a user's locus of interaction moves near a boundary, then perceptibly changes (e.g., abruptly drops or changes direction) when the boundary is traversed.

  7. Human Reliability Program Workshop

    SciTech Connect (OSTI)

    Landers, John; Rogers, Erin; Gerke, Gretchen

    2014-05-18

    A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

  8. Human Performance Modeling for Dynamic Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Joe, Jeffrey Clark; Mandelli, Diego

    2015-08-01

    Part of the U.S. Department of Energy’s (DOE’s) Light Water Reac- tor Sustainability (LWRS) Program, the Risk-Informed Safety Margin Charac- terization (RISMC) Pathway develops approaches to estimating and managing safety margins. RISMC simulations pair deterministic plant physics models with probabilistic risk models. As human interactions are an essential element of plant risk, it is necessary to integrate human actions into the RISMC risk framework. In this paper, we review simulation based and non simulation based human reliability analysis (HRA) methods. This paper summarizes the founda- tional information needed to develop a feasible approach to modeling human in- teractions in RISMC simulations.

  9. PIA - Human Resources - Personal Information Change Request ...

    Energy Savers [EERE]

    Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National...

  10. Careers/ Human Resources | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Employment Opportunities Directory Environment, Safety & Health Furth Plasma Physics Library Lab Leadership Organization Chart Technology Transfer Careers Human ...

  11. The vanishing forest. The human consequences of deforestation

    SciTech Connect (OSTI)

    Not Available

    1986-01-01

    This report highlights the rapid destruction of the world's remaining tropical rainforests. It stresses the devastating consequences, both in the short-term, as developers take over the forests from their indigenous inhabitants, and in the long-term, as deforestation threatens to destroy the vital natural resource, to bring out irreversible climatic changes, and to cause the loss of gene pools needed for future agricultural and medical progress. What we urgently need, this report argues, are policy changes that make forest conversion a vehicle of sustainable development so that human civilization can continue in the tropics, and so that forest areas of particular ecological value are preserved.

  12. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of information on all research projects that involve human subjects and that are funded by DOE, conducted in DOE facilities, performed by DOE personnel or involve DOE or contract personnel. The Oak Ridge Institute for Science and Education (ORISE) maintains the Human Subjects Research Database (HSRD) for the Office of

  13. Quantum physics and human values

    SciTech Connect (OSTI)

    Stapp, H.P.

    1989-09-01

    This report discusses the following concepts: the quantum conception of nature; the quantum conception of man; and the impact upon human values. (LSP).

  14. Human Genome Research: Decoding DNA

    Office of Scientific and Technical Information (OSTI)

    ... Speeding Up the Process of Gene Discovery Engineered Enzyme Accelerates DNA Sequencing Putting a Virus to Practical Use DOE Joint Genome Institute The Human Genome Project: ...

  15. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-07-20

    Changes are made to harmonize the definitions in this Order with those in the Federal regulations for the protection of human subjects (10 CFR Part 745), specifically, splitting the definition "human subject research" into "research" and "human subject," and adopting, verbatim, the definitions of "research" and "human subject" from 10 CFR Part 745 and adding the definition of "generalizable," since the determination of whether a project is "research" in 10 CFR Part 745 hinges on whether the work being conducted is generalizable. Small corrections and updates have been made to the references, links, and organization titles.

  16. Simulating human behavior for national security human interactions.

    SciTech Connect (OSTI)

    Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

    2007-01-01

    This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

  17. The Human Genome Diversity Project

    SciTech Connect (OSTI)

    Cavalli-Sforza, L.

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  18. Human Reliability Analysis for Digital Human-Machine Interfaces

    SciTech Connect (OSTI)

    Ronald L. Boring

    2014-06-01

    This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

  19. Human Genome Education Program

    SciTech Connect (OSTI)

    Richard Myers; Lane Conn

    2000-05-01

    The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will

  20. Human genome. 1993 Program report

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

  1. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

  2. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

  3. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-12-09

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Supersedes DOE O 443.1A and DOE P 443.1A.

  4. Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer

    SciTech Connect (OSTI)

    Chu, Xiufeng; Zhang, Ting; Wang, Jie; Li, Meng; Zhang, Xiaolei; Tu, Jing; Sun, Shiqin; Chen, Xiangmei; Lu, Fengmin

    2014-04-25

    Highlights: The expression of Fbx4 was significantly lower in HCC tissues. Novel splicing variants of Fbx4 were identified. These novel variants are much more abundant in human cancer tissues and cells. The novel Fbx4 isoforms could promote cell proliferation and migration in vitro. These isoforms showed less capability for cyclin D1 binding and degradation. - Abstract: Fbx4 is a specific substrate recognition component of SCF ubiquitin ligases that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. Two isoforms of human Fbx4 protein, the full length Fbx4? and the C-terminal truncated Fbx4? have been identified, but their functions remain elusive. In this study, we demonstrated that the mRNA level of Fbx4 was significantly lower in hepatocellular carcinoma tissues than that in the corresponding non-tumor tissues. More importantly, we identified three novel splicing variants of Fbx4: Fbx4? (missing 168245nt of exon1), Fbx4? (missing exon6) and a N-terminal reading frame shift variant (missing exon2). Using cloning sequencing and RT-PCR, we demonstrated these novel splice variants are much more abundant in human cancer tissues and cell lines than that in normal tissues. When expressed in Sk-Hep1 and NIH3T3 cell lines, Fbx4?, Fbx4? and Fbx4? could promote cell proliferation and migration in vitro. Concordantly, these isoforms could disrupt cyclin D1 degradation and therefore increase cyclin D1 expression. Moreover, unlike the full-length isoform Fbx4? that mainly exists in cytoplasm, Fbx4?, Fbx4?, and Fbx4? locate in both cytoplasm and nucleus. Since cyclin D1 degradation takes place in cytoplasm, the nuclear distribution of these Fbx4 isoforms may not be involved in the down-regulation of cytoplasmic cyclin D1. These results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in

  5. Solar Energy Education. Humanities: activities and teacher's...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Humanities: activities and teacher's guide. Field test edition Citation Details In-Document Search Title: Solar Energy Education. Humanities: activities and teacher's guide. Field ...

  6. Habitat for Humanity | Open Energy Information

    Open Energy Info (EERE)

    Habitat for Humanity Jump to: navigation, search Name: Habitat for Humanity Place: Americus, GA Website: www.habitat.org References: NREL Technical Report: Zero Energy Home1...

  7. Human Reliability Program Orientation for Employees (Technical...

    Office of Scientific and Technical Information (OSTI)

    Human Reliability Program Orientation for Employees Citation Details In-Document Search ... PERSONNEL; RELIABILITY; US DOE HRP employee orientation, human reliability Word ...

  8. Rocky Mountain Humane Investing | Open Energy Information

    Open Energy Info (EERE)

    Rocky Mountain Humane Investing Jump to: navigation, search Name: Rocky Mountain Humane Investing Place: Allenspark, Colorado Zip: 80510 Product: Allenspark-based investment...

  9. Climate Human Capital | Open Energy Information

    Open Energy Info (EERE)

    Human Capital Jump to: navigation, search Name: Climate Human Capital Place: London, United Kingdom Zip: W1K 6NG Sector: Carbon, Renewable Energy, Services Product: Green executive...

  10. Human Capital Management | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    human capital requires comprehensive planning and analysis in order to develop, implement, and evaluate programs that support every facet of employee work life. DOE human capital ...

  11. Human Capital Management Accountability Program (HCMAP) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital Management Accountability Program (HCMAP) is an online program which serves ... and financial HR metrics that assist human resources professionals in identifying ...

  12. PIA - Human Resources - Personal Information Change Request ...

    Broader source: Energy.gov (indexed) [DOE]

    PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory (278.62 KB) More Documents & Publications PIA - INL PeopleSoft - Human ...

  13. PRIVACY IMPACT ASSESSMENT: Human Resources Personal Information

    Broader source: Energy.gov (indexed) [DOE]

    Human Resources - Personal Information Change Request PIA Template Version 3 - May, 2009 ... Name of Information Human Resources - Personal Information Change Request System or IT ...

  14. PIA - Human Resources Management Information System (HRMIS) ...

    Broader source: Energy.gov (indexed) [DOE]

    Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) (490.32 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - ...

  15. Human Capital Organization | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital Officer provides leadership to the Department of Energy (DOE) on the impact and use of policies, proposals, programs, and partnerships related to all aspects of Human ...

  16. Tiny plastic lung mimics human pulmonary function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that ...

  17. Human Resources Specialist - DETAIL (Recruitment) | Department...

    Energy Savers [EERE]

    Human Resources Specialist - DETAIL (Recruitment) Human Resources Specialist - DETAIL (Recruitment) Submitted by admin on Sat, 2016-08-20 00:15 Job Summary Organization Name ...

  18. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Multiscale Simulations of Human Pathologies PI Name: George Karniadakis PI Email: ... of Sickle Hemoglobin Predicting Human Blood Viscosity in Silico Tightly Coupled ...

  19. DOE Human Resources Management Division - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About Hanford Cleanup Hanford History Hanford Site Wide Programs DOE Human Resources ... DOE Human Resources Management Division Email Email Page | Print Print Page | Text ...

  20. ATHENA surrogate human organ system approaches milestone

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Latest Issue:August 2016 all issues All Issues submit ATHENA surrogate human organ ... Editor Ute Haker Email ATHENA, the "Advanced Tissue-engineered Human Ectypal Network ...

  1. Human Resources Generalist | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Generalist Department: Human Resources Supervisor(s): Andrea Moten Staff: AM 3 Requisition Number: 1600683 The HR Generalist is responsible for performing a wide ...

  2. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Alumni Link: Opportunities, News and ... All Issues submit Project ATHENA creates surrogate human organ systems The development ...

  3. The SACADA database for human reliability and human performance

    SciTech Connect (OSTI)

    Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

    2014-05-01

    Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

  4. ATHENA, the Desktop Human "Body"

    SciTech Connect (OSTI)

    Iyer, Rashi; Harris, Jennifer

    2014-09-29

    Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

  5. ATHENA, the Desktop Human "Body"

    ScienceCinema (OSTI)

    Iyer, Rashi; Harris, Jennifer

    2015-01-05

    Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

  6. Human Resources | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Human Resources Human Resources and Administration (HRA) HRA Home About Human Resources Administration SC Correspondence Control Center (SC CCC) Contact Information Human Resources...

  7. Corporate Human Resources Information Services (CHIRS) PIA, Office...

    Broader source: Energy.gov (indexed) [DOE]

    Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol ...

  8. About the Human Resource Management Team | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Human Resource Management Team is responsible for human capital policy, human capital and organizational management, and human capital management initiatives. The team ensures an ...

  9. FAL 2006-04, Financial Assistance Letters Remaining in Effect

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Letters Discontinued Number Date Subject Disposition 2004-03 02122004 Intellectual Property Moved to the Guide to Financial Assistance 2004-06 11022004 Award Terms Moved ...

  10. United States Collaborates with Switzerland to Remove Last Remaining...

    National Nuclear Security Administration (NNSA)

    The plutonium, which originally was intended for research and development of new-generation fuel elements for nuclear reactor plants, belonged to the Swiss Confederation. It had ...

  11. United States, International Partners Remove Last Remaining Weapons...

    Broader source: Energy.gov (indexed) [DOE]

    on a broad range of nuclear security and nonproliferation activities. These include border security and export control cooperation, safeguards information management, and...

  12. Investment in generation is heavy, but important needs remain

    SciTech Connect (OSTI)

    Maize, K.

    2007-01-15

    Forecasting the direction of the US electric power industry for 2007, much less the distant future, is like defining a velocity vector; doing so requires a direction and speed to delineate progress. In this special report, the paper looks at current industry indicators and draws conclusions based on more than 100 years of experience. To borrow verbatim the title of basketball legend Charles Barkely's book 'I may be wrong but I doubt it'. The forecast takes into consideration USDOE's National Electric Transmission Congestion Study (August 2006),a summary of industry data prepared by Industrial Info Resources (IIR) and NERC's 2006 Long-Term Reliability Assessment (October 2006). It also reports opinions of industry specialists. 3 figs., 4 tabs.

  13. Iraq`s significant hydrocarbon potential remains relatively undeveloped

    SciTech Connect (OSTI)

    AL-Gailani, M.

    1996-07-29

    Iraq is probably one of the least explored countries in the Middle East, despite the fact that it possesses one of the richest hydrocarbon basins in the world almost on a par to Saudi Arabia`s potential, if not more. The aim of this article is to state the facts about Iraq and focus on the huge but untapped and undeveloped hydrocarbon resources to the international oil community. Perhaps it is best to start by describing briefly the sedimentary and tectonic elements responsible for accumulating such large hydrocarbon resources. The paper describes the basin, tectonic elements, structural anomalies, deep drilling, source rocks, reservoir rocks, characteristics, and new reserves.

  14. EM's Cleanup Mission: 16 Sites in 11 States Remaining

    Broader source: Energy.gov [DOE]

    At the end of fiscal year 2013, EM completed cleanup and closed 90 sites in 28 states. This included cleanup and closure of 85 smaller sites and five major nuclear sites: Rocky Flats, Fernald, Mound, Pinellas, and Weldon Spring.

  15. US Removes Last Remaining HEU from Czech Republic, Sets Nonproliferati...

    National Nuclear Security Administration (NNSA)

    never acquire a nuclear weapon, and our work ... into low enriched uranium (LEU) for use in power reactors. ... NNSA maintains and enhances the safety, security, ...

  16. U.S. diesel fuel prices remain stable

    U.S. Energy Information Administration (EIA) Indexed Site

    diesel fuel prices increase The U.S. average retail price for on-highway diesel fuel rose to $2.13 a gallon on Monday. That's up 1.3 cents from a week ago, based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the West Coast states at 2.33 a gallon, up 1 ½ cents from a week ago. Prices were lowest in the Gulf Coast states at 1.99 a gallon, up 9-tenths of a penny. This is Amerine Woodyard

  17. NNSA Partnership Successfully Removes All Remaining HEU from...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... research reactors and medical isotope production facilities to the use of LEU, removing excess HEU and separated plutonium, and dispositioning HEU and plutonium domestically. ...

  18. U.S. gasoline prices remain steady (long version)

    U.S. Energy Information Administration (EIA) Indexed Site

    Prices were lowest in the Gulf Coast states at 2.54 a gallon, up 5.3 cents. This is Marlana Anderson, with EIA, in Washington. For more information, contact Marlana Anderson, ...

  19. Questions remain on funding for cleanup of Oak Ridge Reservation

    Broader source: Energy.gov [DOE]

    There is great uncertainty on what the looming federal budget cuts will be and what effect they will have on funding for the Department of Energy’s (DOE) Environmental Management (EM) program at the Oak Ridge Reservation (ORR).

  20. WILD PIG ATTACKS ON HUMANS

    SciTech Connect (OSTI)

    Mayer, J.

    2013-04-12

    Attacks on humans by wild pigs (Sus scrofa) have been documented since ancient times. However, studies characterizing these incidents are lacking. In an effort to better understand this phenomenon, information was collected from 412 wild pig attacks on humans. Similar to studies of large predator attacks on humans, data came from a variety of sources. The various attacks compiled occurred in seven zoogeographic realms. Most attacks occurred within the species native range, and specifically in rural areas. The occurrence was highest during the winter months and daylight hours. Most happened under non-hunting circumstances and appeared to be unprovoked. Wounded animals were the chief cause of these attacks in hunting situations. The animals involved were typically solitary, male and large in size. The fate of the wild pigs involved in these attacks varied depending upon the circumstances, however, most escaped uninjured. Most human victims were adult males traveling on foot and alone. The most frequent outcome for these victims was physical contact/mauling. The severity of resulting injuries ranged from minor to fatal. Most of the mauled victims had injuries to only one part of their bodies, with legs/feet being the most frequent body part injured. Injuries were primarily in the form of lacerations and punctures. Fatalities were typically due to blood loss. In some cases, serious infections or toxemia resulted from the injuries. Other species (i.e., pets and livestock) were also accompanying some of the humans during these attacks. The fates of these animals varied from escaping uninjured to being killed. Frequency data on both non-hunting and hunting incidents of wild pig attacks on humans at the Savannah River Site, South Carolina, showed quantitatively that such incidents are rare.

  1. Low-Income Weatherization: The Human Dimension

    Office of Energy Efficiency and Renewable Energy (EERE)

    This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

  2. Analysis of Human Genetic Linkage

    SciTech Connect (OSTI)

    Boehnke, M.

    1991-01-01

    Linkage analysis continues in its golden age. The convergence of several factors - advances in molecular biology, advances in statistical models and algorithms, and advances in computing technology - have made possible remarkable successes in the mapping of human genetic diseases and in the construction of human genetic maps. The goals of mapping all the most important simple Mendelian disorders and constructing fine-structure genetic maps for each of the human chromosomes soon will be reached, and linkage methods promise to help us understand the etiologies of many common and complex familial diseases. With the continuing rapid advance of the field, the appearance of the revised edition of Dr. Ott's book is particularly welcome. As with the first edition, the goal of the revised edition is to provide a concise, easy-to-read introduction to human linkage analysis. The revised edition includes chapters on basic genetics and cytogenetics, genes and genetic polymorphisms, aspects of statistical inference, methods of linkage analysis, the informativeness of family data, multipoint linkage analysis, penetrance, numerical and computerized methods, the variability of the recombination fraction, inconsistencies, and linkage analysis with disease loci. The results is not an encyclopedia providing everything one could ever want to know about linkage analysis but, rather, a guide to the important methods, topics, and problems of linkage analysis today. Overall, the book achieves an excellent compromise between presenting important conclusions and working out the details.

  3. Human factors in software development

    SciTech Connect (OSTI)

    Curtis, B.

    1986-01-01

    This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

  4. Human retroviruses and AIDS 1994

    SciTech Connect (OSTI)

    Myers, G.; Korber, B.; Wain-Hobson, S.; Jeang, Kuan-Teh; Henderson, L.E.; Pavlakis, G.N.

    1995-01-01

    This compendium, including accompanying floppy diskettes, is the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts it comprises: (I) Nucleic Acid Alignments and Sequences; (II) Amino Acid Alignments; (III) Analysis; (IV) Related Sequences; (V) Database communications.

  5. A Literary Human Exinction Scenario

    SciTech Connect (OSTI)

    Tonn, Bruce Edward

    2009-11-01

    Mary Wollstonecraft Shelly's (MWS) novel, The Last Man, published in 1826, is an epic narrative about the destruction of the human race. This paper provides a synopsis of this book and assesses its relationships to contemporary future studies. The paper also delves into the history of apocalyptic writing and thinking, using this book an entry point to past literature.

  6. Human-computer interface including haptically controlled interactions

    DOE Patents [OSTI]

    Anderson, Thomas G.

    2005-10-11

    The present invention provides a method of human-computer interfacing that provides haptic feedback to control interface interactions such as scrolling or zooming within an application. Haptic feedback in the present method allows the user more intuitive control of the interface interactions, and allows the user's visual focus to remain on the application. The method comprises providing a control domain within which the user can control interactions. For example, a haptic boundary can be provided corresponding to scrollable or scalable portions of the application domain. The user can position a cursor near such a boundary, feeling its presence haptically (reducing the requirement for visual attention for control of scrolling of the display). The user can then apply force relative to the boundary, causing the interface to scroll the domain. The rate of scrolling can be related to the magnitude of applied force, providing the user with additional intuitive, non-visual control of scrolling.

  7. Automated whole-genome multiple alignment of rat, mouse, and human

    SciTech Connect (OSTI)

    Brudno, Michael; Poliakov, Alexander; Salamov, Asaf; Cooper, Gregory M.; Sidow, Arend; Rubin, Edward M.; Solovyev, Victor; Batzoglou, Serafim; Dubchak, Inna

    2004-07-04

    We have built a whole genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline which combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment, and consists of two main steps: (1) alignment of the mouse and rat genomes; and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting alignments demonstrate high sensitivity, with 87% of all human gene-coding areas aligned in both mouse and rat. The specificity is also high: <7% of the rat contigs are aligned to multiple places in human and 97% of all alignments with human sequence > 100kb agree with a three-way synteny map built independently using predicted exons in the three genomes. At the nucleotide level <1% of the rat nucleotides are mapped to multiple places in the human sequence in the alignment; and 96.5% of human nucleotides within all alignments agree with the synteny map. The alignments are publicly available online, with visualization through the novel Multi-VISTA browser that we also present.

  8. Expanding Human Cognition and Communication

    SciTech Connect (OSTI)

    Spohrer, Jim; Pierce, Brian M.; Murray, Cherry A.; Golledge, Reginald G.; Horn, Robert E.; Turkle, Sherry; Yonas, Gerold; Glicken Turnley, Jessica; Pollack, Jordan; Burger, Rudy; Robinett, Warren; Wilson, Larry Todd; Bainbridge, W. S.; Canton, J.; Kuekes, P.; Loomis, J.; Penz, P.

    2013-01-01

    To be able to chart the most profitable future directions for societal transformation and corresponding scientific research, five multidisciplinary themes focused on major goals have been identified to fulfill the overall motivating vision of convergence described in the previous pages. The first, “Expanding Human Cognition and Communication,” is devoted to technological breakthroughs that have the potential to enhance individuals’ mental and interaction abilities. Throughout the twentieth century, a number of purely psychological techniques were offered for strengthening human character and personality, but evaluation research has generally failed to confirm the alleged benefits of these methods (Druckman and Bjork 1992; 1994). Today, there is good reason to believe that a combination of methods, drawing upon varied branches of converging science and technology, would be more effective than attempts that rely upon mental training alone.

  9. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  10. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. This order cancels DOE O 3220.1A, DOE O 3220.4A, DOE O 3220.6A, and DOE O 3309.1A.

  11. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-29

    This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels Chapters I-III of DOE O 350.1 Chg 4

  12. Integrating Human Performance and Technology

    SciTech Connect (OSTI)

    Ronald K. Farris; Heather Medema

    2012-05-01

    Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

  13. Correlation between human observer performance and model observer performance in differential phase contrast CT

    SciTech Connect (OSTI)

    Li, Ke; Garrett, John; Chen, Guang-Hong

    2013-11-15

    curves tended to be steeper. The CHO generated the best quantitative agreement with human observers with its CD curve overlapping with that of human observer. Statistical equivalence between CHO and humans can be claimed within 11% of the human observer results, including both the disk and lesion detection experiments.Conclusions: The model observer method can be used to accurately represent human observer performance with the stochastic DPC-CT noise for SKE tasks with sizes ranging from 8 to 128 pixels. The incorporation of the anatomical noise remains to be studied.

  14. Human Resource Directors (HRD) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Office (NE) 208-526-5711 groseae@id.doe.gov Marcus Lea Director, Office of Human Cap. Mgt. ... garcia@wapa.gov Rita Clinton Director, Human Resources Services (HQ) (202) 586-1038 ...

  15. MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM:

    Broader source: Energy.gov (indexed) [DOE]

    April 27,2010 MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM: s r x j ) bi Le OFFICE HE CHIEF HUMAN CAPITAL OFFICER SUBJECT: GUIDANCE MEMORANDUM 8: DOE FAIR LABOR STANDARDS ACT ...

  16. Mapping the Topology of the Human Genome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mapping the Topology of the Human Genome Mapping the Topology of the Human Genome Print Monday, 11 July 2016 00:00 Department of Energy facilities such as the Joint Genome ...

  17. 6.20 Mapping Human Brain Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose ...

  18. Human Brain vs. Computer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computer Processors Beat the Human Mind in the Future? Click to email this to a friend ... Can Computer Processors Beat the Human Mind in the Future? 2013.01.29 Chief Scientist Jim ...

  19. History of the DOE Human Genome Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief ...

  20. GDB - Human Genome Database final report

    SciTech Connect (OSTI)

    Talbot, C. Conover, Jr.

    2002-01-08

    This is the DOE final report for the GDB, Human Genome Database, project at the Johns Hopkins University.

  1. Identification of Human Repetitive DNA Elements

    Energy Science and Technology Software Center (OSTI)

    1995-11-01

    PYTHIA identifies the subfamily membership of Alu sequences, occurrences of repetitive human DNA elements, and simple DNA sequences.

  2. Human factors: a necessary tool for industry

    SciTech Connect (OSTI)

    Starcher, K.O.

    1984-03-09

    The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

  3. In vitro dermal absorption of pyrethroid pesticides in human and rat skin

    SciTech Connect (OSTI)

    Hughes, Michael F.; Edwards, Brenda C.

    2010-07-15

    Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using

  4. One Size Does Not Fit All: Human Failure Event Decomposition and Task Analysis

    SciTech Connect (OSTI)

    Ronald Laurids Boring, PhD

    2014-09-01

    In the probabilistic safety assessments (PSAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered or exacerbated by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question remains central as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PSAs tend to be top-down—defined as a subset of the PSA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) are more likely to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications. In this paper, I first review top-down and bottom-up approaches for defining HFEs and then present a seven-step guideline to ensure a task analysis completed as part of human error identification decomposes to a level suitable for use as HFEs. This guideline illustrates an effective way to bridge the bottom-up approach with top-down requirements.

  5. Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma

    SciTech Connect (OSTI)

    Radi, Zaher; Bartholomew, Phillip; Elwell, Michael; Vogel, W. Mark

    2013-12-15

    In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tumors. In contrast, spontaneous hibernoma in rats is rare, often malignant, usually occurs in the thoracic or abdominal cavity, and metastases are common. In recent years, there has been an increased incidence of spontaneous hibernomas in rat carcinogenicity studies, but overall the occurrence remains relatively low and highly variable across studies. There have only been four reported examples of pharmaceutical-induced hibernoma in rat carcinogenicity studies. These include phentolamine, an alpha-adrenergic antagonist; varenicline, a nicotine partial agonist; tofacitinib, a Janus kinase (JAK) inhibitor; and hydromorphone, an opiod analgesic. Potential non-genotoxic mechanisms that may contribute to the pathogenesis of BAT activation/proliferation and/or subsequent hibernoma development in rats include: (1) physiological stimuli, (2) sympathetic stimulation, (3) peroxisome proliferator-activated receptor (PPAR) agonism, and/or (4) interference or inhibition of JAK/Signal Transducer and Activator of Transcription (JAK/STAT) signaling. The evaluation of an apparent increase of hibernoma in rats from 2-year carcinogenicity studies of novel pharmaceutical therapeutics and its relevance to human safety risk assessment is complex. One should consider: the genotoxicity of the test article, dose/exposure and safety margins, and pathophysiologic and morphologic differences and similarities of hibernoma between rats and humans. Hibernomas observed to date in carcinogenicity studies of pharmaceutical agents do not appear to be relevant for human risk at therapeutic dosages. - Highlights: Highly variable incidence of spontaneous hibernoma in carcinogenicity studies Recent increase in the spontaneous incidence of hibernomas in

  6. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, supersedes DOE O 350.1 Chg 4. The Order is revised to reflect the cancellation of Chapters 1-3 due to the incorporation of these chapters into DOE Order 350.3; reflect organizational changes; delete reference to the DOE Retrospective Rating Insurance Plan, which is no longer available; remove the CRD from Chapter VII.

  7. Simulation of human decision making

    DOE Patents [OSTI]

    Forsythe, J. Chris; Speed, Ann E.; Jordan, Sabina E.; Xavier, Patrick G.

    2008-05-06

    A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

  8. Models of human operators: Their need and usefulness for improvement of advanced control systems and control rooms

    SciTech Connect (OSTI)

    Knee, H.E.; Schryver, J.C.

    1991-01-01

    Models of human behavior and cognition (HB C) are necessary for understanding the total response of complex systems. Many such model have come available over the past thirty years for various applications. Many potential model users remain skeptical about their practically, acceptability, and usefulness. Such hesitancy stems in part from disbelief in the ability to model complex cognitive processes, and a belief that relevant human behavior can be adequately accounted for through the use of common-sense heuristics. This paper will highlight several models of HB C and identify existing and potential applications in attempt to dispel such notions. 26 refs.

  9. Human Resources and Administration Homepage | U.S. DOE Office...

    Office of Science (SC) Website

    Home Human Resources and Administration (HRA) HRA Home About Human Resources Administration SC Correspondence Control Center (SC CCC) Contact Information Human Resources and...

  10. DOE Strategic Human Capital Plan (FY 2011 - 2015) | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Strategic Human Capital Plan (FY 2011 - 2015) DOE Strategic Human Capital Plan (FY 2011 - 2015) The Strategic Human Capital Plan sets forth the framework for managing the ...

  11. PIA - Human Resources Management System | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    System PIA - Human Resources Management System (218.23 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human Resources - Personal Information ...

  12. PIA - INL PeopleSoft - Human Resource System | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System (333.96 KB) More Documents & Publications PIA - Human Resources - Personal Information Change ...

  13. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong ...

  14. Oldest hominid skeleton provides new evidence for human evolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New evidence for human evolution Oldest hominid skeleton provides new evidence for human evolution The discovery reveals the biology of the first stage of human evolution better ...

  15. Molecular clocks control mutation rate in human cells

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    All Issues submit Molecular clocks control mutation rate in human cells Mutational processes may be responsible for a large proportion of human cancer, contribute to human ...

  16. ATHENA desktop human "body" reduces need for animal drug tests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ATHENA desktop human "body" ATHENA desktop human "body" reduces need for animal drug tests ATHENA project team is developing four human organ constructs that are based on a ...

  17. Human Reliability Analysis for Design: Using Reliability Methods for Human Factors Issues

    SciTech Connect (OSTI)

    Ronald Laurids Boring

    2010-11-01

    This paper reviews the application of human reliability analysis methods to human factors design issues. An application framework is sketched in which aspects of modeling typically found in human reliability analysis are used in a complementary fashion to the existing human factors phases of design and testing. The paper provides best achievable practices for design, testing, and modeling. Such best achievable practices may be used to evaluate and human system interface in the context of design safety certifications.

  18. Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During Infant Gut Colonization Case

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Young, Jacque C.; Pan, Chongle; Adams, Rachel M.; Brooks, Brandon; Banfield, Jillian F.; Morowitz, Michael J.; Robert L. Hettich

    2015-01-01

    The microbial colonization of the human gastrointestinal tract plays an important role in establishing health and homeostasis. However, the time-dependent functional signatures of microbial and human proteins during early colonization of the gut have yet to be determined. Thus, we employed shotgun proteomics to simultaneously monitor microbial and human proteins in fecal samples from a preterm infant during the first month of life. Microbial community complexity and functions increased over time, with compositional changes that were consistent with previous metagenomic and rRNA gene data indicating three distinct colonization phases. Overall microbial community functions were established relatively early in development andmore » remained stable. Human proteins detected included those responsible for epithelial barrier function and antimicrobial activity. Some neutrophil-derived proteins increased in abundance early in the study period, suggesting activation of the innate immune system. Moreover, abundances of cytoskeletal and mucin proteins increased later in the time course, suggestive of subsequent adjustment to the increased microbial load. Our study provides the first snapshot of coordinated human and microbial protein expression in the infant gut during early development.« less

  19. Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During Infant Gut Colonization Case

    SciTech Connect (OSTI)

    Young, Jacque C.; Pan, Chongle; Adams, Rachel M.; Brooks, Brandon; Banfield, Jillian F.; Morowitz, Michael J.; Robert L. Hettich

    2015-01-01

    The microbial colonization of the human gastrointestinal tract plays an important role in establishing health and homeostasis. However, the time-dependent functional signatures of microbial and human proteins during early colonization of the gut have yet to be determined. Thus, we employed shotgun proteomics to simultaneously monitor microbial and human proteins in fecal samples from a preterm infant during the first month of life. Microbial community complexity and functions increased over time, with compositional changes that were consistent with previous metagenomic and rRNA gene data indicating three distinct colonization phases. Overall microbial community functions were established relatively early in development and remained stable. Human proteins detected included those responsible for epithelial barrier function and antimicrobial activity. Some neutrophil-derived proteins increased in abundance early in the study period, suggesting activation of the innate immune system. Moreover, abundances of cytoskeletal and mucin proteins increased later in the time course, suggestive of subsequent adjustment to the increased microbial load. Our study provides the first snapshot of coordinated human and microbial protein expression in the infant gut during early development.

  20. Linking Humans and Systems in Nuclear Power

    SciTech Connect (OSTI)

    Jacques Hugo

    2013-02-01

    Traditional engineering methods do not make provision for the integration of human considerations, while traditional human factors methods do not scale well to the complexity of large-scale nuclear power plant projects. Although the need for up-to-date human factors engineering processes and tools is recognised widely in industry, so far no formal guidance has been developed. This article proposes such a framework.

  1. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Project ATHENA creates surrogate human organ systems The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. June 15, 2015 ATHENA prototype undergoes testing. ATHENA prototype undergoes testing. Contact Los Alamos National Laboratory Kevin Roark Communications Office (505) 665-9202 Email "By developing

  2. Apparatus and methods for a human extender

    DOE Patents [OSTI]

    Jansen, John F.

    2001-01-01

    A human extender controller for interface between a human operator and a physical object through a physical plant. The human extender controller uses an inner-feedback loop to increase the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human extender controller of the present invention is greatly enhanced over that of the prior art, the present invention is able to achieve a force reflection ratio 500 to 1 and capable of handling loads above the two (2) ton range.

  3. Transactions, Technology and Contractor Human Relations | Department...

    Office of Environmental Management (EM)

    of the Assistant General Counsel for Contractor Human Resources (GC-63) Litigation, Regulation and Enforcement Environment and Compliance Transactions, Technology and Contractor ...

  4. Transactions, Technology & Contractor Human Resources | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Panel Technician | Credit: DOE Archives Solar Panel Technician | Credit: DOE Archives Offices of the Deputy General Counsel for Transactions, Technology, & Contractor Human...

  5. Human factors challenges for advanced process control

    SciTech Connect (OSTI)

    Stubler, W.F.; O`Hara, J..M.

    1996-08-01

    New human-system interface technologies provide opportunities for improving operator and plant performance. However, if these technologies are not properly implemented, they may introduce new challenges to performance and safety. This paper reports the results from a survey of human factors considerations that arise in the implementation of advanced human-system interface technologies in process control and other complex systems. General trends were identified for several areas based on a review of technical literature and a combination of interviews and site visits with process control organizations. Human factors considerations are discussed for two of these areas, automation and controls.

  6. Human Capital Management Accountability Program (HCMAP)

    Broader source: Energy.gov [DOE]

    Human Capital Management Accountability Program (HCMAP) is an online program which serves as the vehicle for identifying and measuring these three factors, effectiveness, efficiency, and timeliness...

  7. 2014 DOE Human Reliability Program (HRP) Workshop

    Office of Energy Efficiency and Renewable Energy (EERE)

    2014 DOE Human Reliability Program (HRP) Workshop - September 17-19, at the DOE National Training Center in Albuquerque, New Mexico.

  8. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inset shows the time evolution of thrombus formation. George Karniadakis, Brown University Multiscale Simulations of Human Pathologies PI Name: George Karniadakis PI Email: ...

  9. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Karniadakis, Paris Perdikaris, and Yue Yu, Brown University; Leopold Grinberg, IBM T. J. Watson Research Center and Brown University Multiscale Simulations of Human Pathologies PI ...

  10. Immunogenic compositions comprising human immunodeficiency virus...

    Office of Scientific and Technical Information (OSTI)

    Patent: Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins Citation Details In-Document Search Title: Immunogenic compositions comprising...

  11. Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer

    SciTech Connect (OSTI)

    Staquicini, Fernanda I.; Qian, Ming D.; Salameh, Ahmad; Dobroff, Andrey S.; Edwards, Julianna K.; Cimino, Daniel F.; Moeller, Benjamin J.; Kelly, Patrick; Nunez, Maria I.; Tang, Ximing; Liu, Diane D.; Lee, J. Jack; Hong, Waun Ki; Ferrara, Fortunato; Bradbury, Andrew R. M.; Lobb, Roy R.; Edelman, Martin J.; Sidman, Richard L.; Wistuba, Ignacio I.; Arap, Wadih; Pasqualini, Renata

    2015-03-20

    Lung cancer is often refractory to radiotherapy, but molecular mechanisms of tumor resistance remain poorly defined. Here we show that the receptor tyrosine kinase EphA5 is specifically overexpressed in lung cancer and is involved in regulating cellular responses to genotoxic insult. In the absence of EphA5, lung cancer cells displayed a defective G1/S cell cycle checkpoint, were unable to resolve DNA damage, and became radiosensitive. Upon irradiation, EphA5 was transported into the nucleus where it interacted with activated ATM (ataxia-telangiectasia mutated) at sites of DNA repair. In conclusion, we demonstrate that a new monoclonal antibody against human EphA5 sensitized lung cancer cells and human lung cancer xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of translational applications.

  12. Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Staquicini, Fernanda I.; Qian, Ming D.; Salameh, Ahmad; Dobroff, Andrey S.; Edwards, Julianna K.; Cimino, Daniel F.; Moeller, Benjamin J.; Kelly, Patrick; Nunez, Maria I.; Tang, Ximing; et al

    2015-03-20

    Lung cancer is often refractory to radiotherapy, but molecular mechanisms of tumor resistance remain poorly defined. Here we show that the receptor tyrosine kinase EphA5 is specifically overexpressed in lung cancer and is involved in regulating cellular responses to genotoxic insult. In the absence of EphA5, lung cancer cells displayed a defective G1/S cell cycle checkpoint, were unable to resolve DNA damage, and became radiosensitive. Upon irradiation, EphA5 was transported into the nucleus where it interacted with activated ATM (ataxia-telangiectasia mutated) at sites of DNA repair. In conclusion, we demonstrate that a new monoclonal antibody against human EphA5 sensitized lungmore » cancer cells and human lung cancer xenografts to radiotherapy and significantly prolonged survival, thus suggesting the likelihood of translational applications.« less

  13. Atomic magnetometer for human magnetoencephalograpy.

    SciTech Connect (OSTI)

    Schwindt, Peter; Johnson, Cort N.

    2010-12-01

    We have developed a high sensitivity (<5 fTesla/{radical}Hz), fiber-optically coupled magnetometer to detect magnetic fields produced by the human brain. This is the first demonstration of a noncryogenic sensor that could replace cryogenic superconducting quantum interference device (SQUID) magnetometers in magnetoencephalography (MEG) and is an important advance in realizing cost-effective MEG. Within the sensor, a rubidium vapor is optically pumped with 795 laser light while field-induced optical rotations are measured with 780 nm laser light. Both beams share a single optical axis to maximize simplicity and compactness. In collaboration with neuroscientists at The Mind Research Network in Albuquerque, NM, the evoked responses resulting from median nerve and auditory stimulation were recorded with the atomic magnetometer and a commercial SQUID-based MEG system with signals comparing favorably. Multi-sensor operation has been demonstrated with two AMs placed on opposite sides of the head. Straightforward miniaturization would enable high-density sensor arrays for whole-head magnetoencephalography.

  14. Radium in Humans: A Review of U.S. Studies.

    DOE R&D Accomplishments [OSTI]

    Rowland, R. E.

    1994-09-01

    This document was originally conceived as a description of the radium studies that took place at Argonne National Laboratory. It soon became evident, however, that to document the widespread use of radium, a brief review of the application of radium in medicine and in the US dial painting industry is required. Further, because the Argonne studies were not the only such efforts, brief overviews of the other radium programs are included. Even so, much material has been omitted. The extensive references included will allow the interested reader to find additional information. The effects of internally deposited radium in humans have been studied in this country for more than 75 years. Some 2,400 subjects have had their body contents of radium measured, and a majority of them have been followed for most of their adult lives, to understand and quantify the effects of radium. Many more individuals acquired radium internally but were never measured. Some of this group have been located and followed until death; in these cases the cause of death is known without a body content measurement. As a consequence of the efforts made to locate, measure, and follow exposed individuals, a great deal of information about the effects of radium is available. Nevertheless, great gaps remain in the knowledge of radium toxicity. The Argonne study is the largest every undertaken of the effects on humans of an internally deposited radioelement, in which the insult has been quantitated by actual measurements of the retained radioisotope. The study has now been terminated, even though more than 1,000 subjects with measured radium burdens are still alive. This document is written as a brief summary of current knowledge accumulated in this incomplete study.

  15. Human retroviruses and AIDS 1997

    SciTech Connect (OSTI)

    Korber, B.; Foley, B.; Leitner, T.

    1997-12-01

    This compendium is the result of an effort to compile, organize, and rapidly publish as much relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses as possible. The scope of the compendium and database is best summarized by the four parts that it comprises: (1) Nucleic Acid Alignments, (2) Amino Acid Alignments, (3) Reviews and Analyses, and (4) Related Sequences. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. This year we are not including floppy diskettes as the entire compendium is available both at our Web site and at our ftp site. If you need floppy diskettes please contact either Bette Korber (btk@t10.lanl.gov) or Kersti Rock (karm@t10.lanl.gov) by email or fax ((505) 665-4453). While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. The exception to this are reviews submitted by experts in areas deemed of particular and basic importance to research involving AIDS viral sequence information. These are included in Part III, and are contributed by scientists with particular expertise in the area of interest. In addition to the general descriptions below of the parts of the compendium, the user should read the individual introductions for each part.

  16. Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McWilliams-Koeppen, Helen P.; Foster, James S.; Hackenbrack, Nicole; Ramirez-Alvarado, Marina; Donohoe, Dallas; Williams, Angela; Macy, Sallie; Wooliver, Craig; Wortham, Dale; Morrell-Falvey, Jennifer; et al

    2015-09-22

    Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis. AL is characterized by the production of monoclonal free light chains that deposit as amyloid fibrils principally in the heart, liver, and kidneys causing organ dysfunction. We have studied the effects of amyloid fibrils, produced from recombinant λ6 light chain variable domains, on metabolic activity of human cardiomyocytes. The data indicate that fibrils at 0.1 μM, but not monomer, significantly decrease the enzymatic activity of cellular NAD(P)H-dependent oxidoreductase, without causing significant cell death. The presencemore » of amyloid fibrils did not affect ATP levels; however, oxygen consumption was increased and reactive oxygen species were detected. Confocal fluorescence microscopy showed that fibrils bound to and remained at the cell surface with little fibril internalization. Ultimately, these data indicate that AL amyloid fibrils severely impair cardiomyocyte metabolism in a dose dependent manner. These data suggest that effective therapeutic intervention for these patients should include methods for removing potentially toxic amyloid fibrils.« less

  17. Human Reliability Considerations for Small Modular Reactors

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, H.; DAgostino, A.; Erasmia, L.

    2012-01-27

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations. The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to illustrate how the issues can support SMR probabilistic risk analyses and their review by identifying potential human failure events for a subset of the issues. As part of addressing the human contribution to plant risk, human reliability analysis practitioners identify and quantify the human failure events that can negatively impact normal or emergency plant operations. The results illustrated here can be generalized to identify additional human failure events for the issues discussed and can be applied to those issues not discussed in this report.

  18. Human dopamine receptor and its uses

    DOE Patents [OSTI]

    Civelli, Olivier; Van Tol, Hubert Henri-Marie

    1999-01-01

    The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.

  19. Mapping the Topology of the Human Genome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mapping the Topology of the Human Genome Mapping the Topology of the Human Genome Print Monday, 11 July 2016 00:00 Department of Energy facilities such as the Joint Genome Institute provide us with DNA sequences for entire genomes, most famously the human genome. However, a DNA sequence alone isn't sufficient to determine how a gene will function in a cell, or if indeed it will be functional at all. We also need to know the spatial 3D arrangement of the genome in the nucleus. A single strand of

  20. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons

    SciTech Connect (OSTI)

    Wang, Qian-fei; Liu, Xin; O'Connell, Jeff; Peng, Ze; Krauss, Ronald M.; Rainwater, David L.; VandeBerg, John L.; Rubin, Edward M.; Cheng, Jan-Fang; Pennacchio, Len A.

    2003-09-15

    Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however, whether independently arising polymorphisms in orthologous regions of non-human primates leads to similar variation in a quantitative trait found in both species. To explore this paradigm, we studied a baboon apolipoprotein gene cluster (APOA1/C3/A4/A5) for which the human gene orthologs have well established roles in influencing plasma HDL-cholesterol and triglyceride concentrations. Our extensive polymorphism analysis of this 68 kb gene cluster in 96 pedigreed baboons identified several haplotype blocks each with limited diversity, consistent with haplotype findings in humans. To determine whether baboons, like humans, also have particular haplotypes associated with lipid phenotypes, we genotyped 634 well characterized baboons using 16 haplotype tagging SNPs. Genetic analysis of single SNPs, as well as haplotypes, revealed an association of APOA5 and APOC3 variants with HDL cholesterol and triglyceride concentrations, respectively. Thus, independent variation in orthologous genomic intervals does associate with similar quantitative lipid traits in both species, supporting the possibility of uncovering human QTL genes in a highly controlled non-human primate model.

  1. Enhancing Human and Planetary Health Through Innovation

    SciTech Connect (OSTI)

    Brown, Ben

    2014-10-17

    Ben Brown mesmerizes the audience on how to enhance human and planetary health through innovation at our '8 Big Ideas' Science at the Theater event on October 8th, 2014, in Oakland, California.

  2. Implications of the Human Genome Project

    SciTech Connect (OSTI)

    Kitcher, P.

    1998-11-01

    The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and social problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.

  3. 2011-2015 Human Capital Management Plan

    Broader source: Energy.gov [DOE]

    The Office of Legacy Management (LM) needs skilled and engaged staff to accomplish our mission and carry out our responsibilities to the American people. This Human Capital Management Plan (HCMP or...

  4. 2016-2020 Strategic Human Capital Plan

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Chief Human Capital Officer 2016-2020 Strategic Human Capital Plan Cover Photo Description Beyond Double-Pane Windows While the invention of double-pane windows dates back to 1935, a true turning point in the technology came in the 1980s with a collaboration between the Department of Energy, private industry, and Lawrence Berkeley National Lab. Initial research and development by Berkeley Lab and a start-up company, Suntek Research Associates (now called Southwall Technologies), led to the

  5. Human Capital Accountability Program--Withdrawn

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-11-15

    Withdrawn 3-26-14. The purpose of maintaining and updating this directive is to (1) Ensure compliance with applicable laws, regulations, and other directives. (2) Reduce the risk of DOE losing any of its personnel authorities. (3) Incorporate functional accountability to ensure that Human Resource Directors' position descriptions and classifications are appropriate, selections result in quality leadership with skills needed, and performance plans and evaluations are consistent with Department and Administration human resources priorities and audit findings.

  6. A New Link Between Human and Bacterial Signaling Machinery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Link Between Human and Bacterial Signaling Machinery A New Link Between Human and Bacterial Signaling Machinery Print Tuesday, 19 August 2014 10:34 The human immune system...

  7. Functional and Structural Characterization of Human V3-Specific...

    Office of Scientific and Technical Information (OSTI)

    Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 ... Title: Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody ...

  8. Microsoft PowerPoint - Crouther.HumanCapitalInitiatives.042909

    Office of Environmental Management (EM)

    Human Capital Initiatives Presented to the Environmental Management Advisory Board (EMAB) By Desi Crouther, Acting Director Office of Human Capital Office of Environmental Management ...

  9. Molecular details of a starch utilization pathway in the human...

    Office of Scientific and Technical Information (OSTI)

    pathway in the human gut symbiont Eubacterium rectale Citation Details In-Document Search Title: Molecular details of a starch utilization pathway in the human gut symbiont ...

  10. Crystal structure of the human [sigma]1 receptor (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    Crystal structure of the human sigma1 receptor Citation Details In-Document Search Title: Crystal structure of the human sigma1 receptor Authors: Schmidt, Hayden R. ; Zheng, ...

  11. Response of Human Lung Epithelial Cells to Engineered Nanoparticles...

    Office of Scientific and Technical Information (OSTI)

    Response of Human Lung Epithelial Cells to Engineered Nanoparticles. Citation Details In-Document Search Title: Response of Human Lung Epithelial Cells to Engineered Nanoparticles. ...

  12. Xylan utilization in human gut commensal bacteria is orchestrated...

    Office of Scientific and Technical Information (OSTI)

    Xylan utilization in human gut commensal bacteria is orchestrated by unique modular ... Title: Xylan utilization in human gut commensal bacteria is orchestrated by unique modular ...

  13. Characterizing Loop Dynamics and Ligand Recognition in Human...

    Office of Scientific and Technical Information (OSTI)

    Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza ... Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born ...

  14. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

  15. UNDP-Human Development Reports | Open Energy Information

    Open Energy Info (EERE)

    Human Development Reports Jump to: navigation, search Tool Summary LAUNCH TOOL Name: UNDP-Human Development Reports AgencyCompany Organization: United Nations Development...

  16. Human Capital: The Role of Ombudsmen in Dispute Resolution

    Broader source: Energy.gov (indexed) [DOE]

    United States General Accounting Office GAO April 2001 HUMAN CAPITAL The Role of Ombudsmen ... Accounting Office GS General Schedule HR human resource IBB International Broadcasting ...

  17. Office of the Chief Human Capital Officer | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Office of the Chief Human Capital Officer Most Requested Benefits CHRIS (DOE Only) DOE & ... HR Contacts by Sub Agency Servicing Area HC Contacts by Functional Area Human Resource ...

  18. PIA - Savannah River Nuclear Solutions (SRNS) Human Resource...

    Broader source: Energy.gov (indexed) [DOE]

    (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) (3.39 MB) More Documents & Publications PIA - ...

  19. 2014 Human Reliability Program Workshop Agenda | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    September 17-19, 2014 2014 DOE Human Reliability Program Workshop And Webinar Agenda DOE ... 10 Code of Federal Regulations Part 712, Human Reliability Program INSPECTION REPORT: ...

  20. Manager's Desk Reference on Human Capital Management Flexibilities...

    Broader source: Energy.gov (indexed) [DOE]

    that can be used in day-to-day human capital management activities, especially ... Manager's Desk Reference on Human Capital Management Flexibilities (640.69 KB) Responsible ...

  1. Human Capital Policy Division (HC-11) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Provide a full range of staff support to the Chief Human Capital Officer including support required for internal and external responsibilities. Develop and revise the agency human ...

  2. DOE Strategic Human Capital Plan | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    The current Strategic Human Capital Plan (SHCP) sets forth the framework for managing the Department of Energy's (DOE) human capital system through 2020. This Plan, which replaces ...

  3. First Steps Toward Tribal Weatherization - Human Capacity Development...

    Broader source: Energy.gov (indexed) [DOE]

    Toward Tribal Weatherization - Human Capacity Development (DE-PA36-09GO99022) 2006 All ... Weatherization Training Program Phase 1: Development of human capacity to deliver ...

  4. Office of the Chief Human Capital Officer (HC-1) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    HC-1 Mission and Function Statement The Office of the Chief Human Capital Officer (HC) ... agreementsrelationships related to all aspects of Human Capital Management (HCM). ...

  5. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management...

    Broader source: Energy.gov (indexed) [DOE]

    Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and ...

  6. Office of Human Resource Services (HC-30) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    This organization provides a full range of human capital management (HCM) operational ... Leadership Rita M. Clinton Director, Office of Human Resource Services Read Bio HC-30 ...

  7. Yurok Tribe - Tribal Utility Project and Human Capacity Building

    Broader source: Energy.gov (indexed) [DOE]

    Study (completed June 30, 2007) 2. Human Capacity Building in Energy Efficiency and ... Facility (QF) Possible Grant Funding Human Capacity Building Project Project Team ...

  8. Human Resources at Ames Laboratory | Critical Materials Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contact Information Contact information for Human Resources staff within The Ames Laboratory. Human Resources Office 105 TASF 515-294-2680 Diane Muncrief Manager Labor Relations - ...

  9. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic ...

  10. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutrons provide new insights into human cell behavior Community Connections: Your link to ... All Issues submit Neutrons provide new insights into human cell behavior Physics and ...

  11. COLLOQUIUM: The Power of Neuroplasticity: Enhancing Human Potential...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    COLLOQUIUM: The Power of Neuroplasticity: Enhancing Human Potential Dr. Paula Tallal ... designed based on research findings from human and animal research and translated into ...

  12. Antibody library project could unlock mysteries of human gene...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mysteries of human gene function Antibody library project could unlock mysteries of human gene function By looking at antibodies, researchers can identify where, in a cell, genes ...

  13. Molecular clocks control mutation rate in human cells

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular clocks control mutation rate in human cells Molecular clocks control mutation rate in human cells These clock-like mutational processes could ultimately be responsible ...

  14. Scientists call for antibody 'bar code' system to follow Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists call for antibody 'bar code' system to follow Human Genome Project Researchers ... on the scale of the now-completed Human Genome Project. (Image: Public Domain, ...

  15. Modeling and Simulation of Human Behavior in Buildings

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Laboratory Modeling and Simulation of Human Behavior in Buildings 2015 Building ... to IEA EBC Annex 66 4 Complexity of Human Behavior * Inherent uncertainty * ...

  16. River Corridor Baseline Risk Assessment (RCBRA) Human Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12, 2011 River Corridor Baseline Risk Assessment (RCBRA) Human Health Risk Assessment (Volume 2) * RCBRA Human Health Risk Assessment is final - Response provided to HAB ...

  17. Structure of Human Argonaute2: A Programmable Ribonuclease |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Argonaute2: A Programmable Ribonuclease Wednesday, July 31, 2013 Ribonucleases ... Institute were able to solve the three-dimensional structure of human Argonaute2 (Fig 1A). ...

  18. "OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    "OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot, Department of Molecular Biology, Biochemistry and Physics, Rutgers University OUT OF AFRICA: GENETICS AND HUMAN ...

  19. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutrons provide new insights into human cell behavior Alumni Link: Opportunities, News ... All Issues submit Neutrons provide new insights into human cell behavior Physics and ...

  20. Human Factors Engineering Analysis Tool - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Factors Engineering Analysis Tool Software tool that enables easy and quick selection of applicable regulatory guidelines as starting point for human factors engineering ...

  1. Scientists call for antibody 'bar code' system to follow Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists call for antibody 'bar code' system to follow Human Genome Project Alumni Link: ... Scientists call for antibody 'bar code' system to follow Human Genome Project Researchers ...

  2. Human Resources | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Integrated Support Center (ISC) ISC Home About Services Freedom of ... Services Human Resources Print Text Size: A A A FeedbackShare Page Related Links Forms ...

  3. The Oak Ridge Institute for Science and Education Human Subjects...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Program PrivacySecurity Statement Contact | Forms PurposeMission ... The Oak Ridge Institute for Science and Education (ORISE) Human Subjects Research Program ...

  4. Structure of the human M2 muscarinic acetylcholine receptor bound...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist Citation Details In-Document Search Title: Structure of the human M2 muscarinic acetylcholine ...

  5. Stories of Discovery & Innovation: From Human Genome to Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    From Human Genome to Materials "Genome" Energy Frontier Research Centers (EFRCs) EFRCs ... Stories of Discovery & Innovation: From Human Genome to Materials "Genome" Print Text ...

  6. Fossil analysis pushes back human split from other primates by...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fossil analysis pushes back human split from other primates Fossil analysis pushes back human split from other primates by two million years C. abyssinicus revealed answers about ...

  7. Human Subjects Protection Program Homepage | U.S. DOE Office...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HSPP Home Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review ... Contact BER Home Contact Information Human Subjects Protection Program U.S. ...

  8. Human immunodeficiency virus type 1 clade M mosaic gag polypeptides...

    Office of Scientific and Technical Information (OSTI)

    Patent: Human immunodeficiency virus type 1 clade M mosaic gag polypeptides Citation Details In-Document Search Title: Human immunodeficiency virus type 1 clade M mosaic gag ...

  9. Mapping and Sequencing the Human Genome

    DOE R&D Accomplishments [OSTI]

    1988-01-01

    Numerous meetings have been held and a debate has developed in the biological community over the merits of mapping and sequencing the human genome. In response a committee to examine the desirability and feasibility of mapping and sequencing the human genome was formed to suggest options for implementing the project. The committee asked many questions. Should the analysis of the human genome be left entirely to the traditionally uncoordinated, but highly successful, support systems that fund the vast majority of biomedical research. Or should a more focused and coordinated additional support system be developed that is limited to encouraging and facilitating the mapping and eventual sequencing of the human genome. If so, how can this be done without distorting the broader goals of biological research that are crucial for any understanding of the data generated in such a human genome project. As the committee became better informed on the many relevant issues, the opinions of its members coalesced, producing a shared consensus of what should be done. This report reflects that consensus.

  10. A technique for human error analysis (ATHEANA)

    SciTech Connect (OSTI)

    Cooper, S.E.; Ramey-Smith, A.M.; Wreathall, J.; Parry, G.W.

    1996-05-01

    Probabilistic risk assessment (PRA) has become an important tool in the nuclear power industry, both for the Nuclear Regulatory Commission (NRC) and the operating utilities. Human reliability analysis (HRA) is a critical element of PRA; however, limitations in the analysis of human actions in PRAs have long been recognized as a constraint when using PRA. A multidisciplinary HRA framework has been developed with the objective of providing a structured approach for analyzing operating experience and understanding nuclear plant safety, human error, and the underlying factors that affect them. The concepts of the framework have matured into a rudimentary working HRA method. A trial application of the method has demonstrated that it is possible to identify potentially significant human failure events from actual operating experience which are not generally included in current PRAs, as well as to identify associated performance shaping factors and plant conditions that have an observable impact on the frequency of core damage. A general process was developed, albeit in preliminary form, that addresses the iterative steps of defining human failure events and estimating their probabilities using search schemes. Additionally, a knowledge- base was developed which describes the links between performance shaping factors and resulting unsafe actions.

  11. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus

    SciTech Connect (OSTI)

    Hu, Liya; Ramani, Sasirekha; Czako, Rita; Sankaran, Banumathi; Yu, Ying; Smith, David F.; Cummings, Richard D.; Estes, Mary K.; Venkataram Prasad, B. V.

    2015-09-30

    We report that strain-dependent variation of glycan recognition during initial cell attachment of viruses is a critical determinant of host specificity, tissue-tropism and zoonosis. Rotaviruses (RVs), which cause life-threatening gastroenteritis in infants and children, display significant genotype-dependent variations in glycan recognition resulting from sequence alterations in the VP8* domain of the spike protein VP4. The structural basis of this genotype-dependent glycan specificity, particularly in human RVs, remains poorly understood. Here, from crystallographic studies, we show how genotypic variations configure a novel binding site in the VP8* of a neonate-specific bovine-human reassortant to uniquely recognize either type I or type II precursor glycans, and to restrict type II glycan binding in the bovine counterpart. In conclusion, such a distinct glycan-binding site that allows differential recognition of the precursor glycans, which are developmentally regulated in the neonate gut and abundant in bovine and human milk provides a basis for age-restricted tropism and zoonotic transmission of G10P[11] rotaviruses.

  12. Human Factors Engineering Program Review Model (NUREG-0711)Revision 3: Update Methodology and Key Revisions

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, J.; Fleger, S.

    2012-07-22

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. NUREG-0711 is the first document to be addressed. We present the methodology used to update NUREG-0711 and summarize the main changes made. Finally, we discuss the current status of the update program and the future plans.

  13. Updating Human Factors Engineering Guidelines for Conducting Safety Reviews of Nuclear Power Plants

    SciTech Connect (OSTI)

    O, J.M.; Higgins, J.; Stephen Fleger - NRC

    2011-09-19

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. This paper describes the role of HFE guidelines in the safety review process and the content of the key HFE guidelines used. Then we will present the methodology used to develop HFE guidance and update these documents, and describe the current status of the update program.

  14. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hu, Liya; Ramani, Sasirekha; Czako, Rita; Sankaran, Banumathi; Yu, Ying; Smith, David F.; Cummings, Richard D.; Estes, Mary K.; Venkataram Prasad, B. V.

    2015-09-30

    We report that strain-dependent variation of glycan recognition during initial cell attachment of viruses is a critical determinant of host specificity, tissue-tropism and zoonosis. Rotaviruses (RVs), which cause life-threatening gastroenteritis in infants and children, display significant genotype-dependent variations in glycan recognition resulting from sequence alterations in the VP8* domain of the spike protein VP4. The structural basis of this genotype-dependent glycan specificity, particularly in human RVs, remains poorly understood. Here, from crystallographic studies, we show how genotypic variations configure a novel binding site in the VP8* of a neonate-specific bovine-human reassortant to uniquely recognize either type I or type IImore » precursor glycans, and to restrict type II glycan binding in the bovine counterpart. In conclusion, such a distinct glycan-binding site that allows differential recognition of the precursor glycans, which are developmentally regulated in the neonate gut and abundant in bovine and human milk provides a basis for age-restricted tropism and zoonotic transmission of G10P[11] rotaviruses.« less

  15. Ontology-enriched Visualization of Human Anatomy

    SciTech Connect (OSTI)

    Pouchard, LC

    2005-12-20

    The project focuses on the problem of presenting a human anatomical 3D model associated with other types of human systemic information ranging from physiological to anatomical information while navigating the 3D model. We propose a solution that integrates a visual 3D interface and navigation features with the display of structured information contained in an ontology of anatomy where the structures of the human body are formally and semantically linked. The displayed and annotated anatomy serves as a visual entry point into a patient's anatomy, medical indicators and other information. The ontology of medical information provides labeling to the highlighted anatomical parts in the 3D display. Because of the logical organization and links between anatomical objects found in the ontology and associated 3D model, the analysis of a structure by a physician is greatly enhanced. Navigation within the 3D visualization and between this visualization and objects representing anatomical concepts within the model is also featured.

  16. Advancing Usability Evaluation through Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman

    2005-07-01

    This paper introduces a novel augmentation to the current heuristic usability evaluation methodology. The SPAR-H human reliability analysis method was developed for categorizing human performance in nuclear power plants. Despite the specialized use of SPAR-H for safety critical scenarios, the method also holds promise for use in commercial off-the-shelf software usability evaluations. The SPAR-H method shares task analysis underpinnings with human-computer interaction, and it can be easily adapted to incorporate usability heuristics as performance shaping factors. By assigning probabilistic modifiers to heuristics, it is possible to arrive at the usability error probability (UEP). This UEP is not a literal probability of error but nonetheless provides a quantitative basis to heuristic evaluation. When combined with a consequence matrix for usability errors, this method affords ready prioritization of usability issues.

  17. Human factors in nuclear technology - a history

    SciTech Connect (OSTI)

    Jones, D.B. )

    1992-01-01

    Human factors, human factors engineering (HFE), or ergonomics did not receive much formal attention in nuclear technology prior to the Three Mile Island Unit 2 (TMI-2) incident. Three principal reasons exist for this lack of concern. First, emerging technologies show little concern with how people will use a new system. Making the new technology work is considered more important than the people who will use it. Second, the culture of the users of nuclear power did not recognize a need for human factors. Traditional utilities had well established and effective engineering designs for control of electric power generation, while medicine considered the use of nuclear isotopes another useful tool, not requiring special ergonomics. Finally, the nuclear industry owed much to Admiral Rickover. He was definitely opposed.

  18. Annotated bibliography of human factors applications literature

    SciTech Connect (OSTI)

    McCafferty, D.B.

    1984-09-30

    This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

  19. Modeling human risk: Cell & molecular biology in context

    SciTech Connect (OSTI)

    1997-06-01

    It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high dose-rate, whereas in space, with the exception of solar particle events, radiation exposures will be low-dose, low dose-rate; (3) Although it has been established that the virtual absence of gravity in space has a profound effect on human physiology, it is not clear whether these effects will act synergistically with those of radiation exposure. A select panel will evaluate the utilizing experiments and models to accurately predict the risks associated with exposure to HZE particles. Topics of research include cellular and tissue response, health effects associated with radiation damage, model animal systems, and critical markers of Radiation response.

  20. Protection of Human Subjects in Classified Research

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-01-21

    This notice supplements DOE O 443.1B and 10 CFR Part 745 by addressing the Department of Energy (DOE)-specific requirements for the protection of human subjects involved in research that is classified, in whole or in part.

  1. Report on the Human Genome Initiative

    SciTech Connect (OSTI)

    Tinoco, I.; Cahill, G.; Cantor, C.; Caskey, T.; Dulbecco, R.; Engelhardt, D. L.; Hood, L.; Lerman, L. S.; Mendelsohn, M. L.; Sinsheimer, R. L.; Smith, T.; Soll, D.; Stormo, G.; White, R. L.

    1987-04-01

    The report urges DOE and the Nation to commit to a large. multi-year. multidisciplinary. technological undertaking to order and sequence the human genome. This effort will first require significant innovation in general capability to manipulate DNA. major new analytical methods for ordering and sequencing. theoretical developments in computer science and mathematical biology, and great expansions in our ability to store and manipulate the information and to interface it with other large and diverse genetic databases. The actual ordering and sequencing involves the coordinated processing of some 3 billion bases from a reference human genome. Science is poised on the rudimentary edge of being able to read and understand human genes. A concerted. broadly based. scientific effort to provide new methods of sufficient power and scale should transform this activity from an inefficient one-gene-at-a-time. single laboratory effort into a coordinated. worldwide. comprehensive reading of "the book of man". The effort will be extraordinary in scope and magnitude. but so will be the benefit to biological understanding. new technology and the diagnosis and treatment of human disease.

  2. Human Health Science Building Geothermal Heat Pumps

    Broader source: Energy.gov [DOE]

    Project objectives: Construct a ground sourced heat pump, heating, ventilation, and air conditioning system for the new Oakland University Human Health Sciences Building utilizing variable refrigerant flow (VRF) heat pumps. A pair of dedicated outdoor air supply units will utilize a thermally regenerated desiccant dehumidification section. A large solar thermal system along with a natural gas backup boiler will provide the thermal regeneration energy.

  3. Top-down and bottom-up definitions of human failure events in human reliability analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids

    2014-10-01

    In the probabilistic risk assessments (PRAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question is crucial, however, as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PRAs tend to be top-down—defined as a subset of the PRA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) often tend to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications.

  4. Project ATHENA Creates Surrogate Human Organ Systems

    SciTech Connect (OSTI)

    MacQueen, Luke; Knospel, Fanny; Sherrod, Stacy; Iyer, Rashi

    2015-06-15

    The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By developing this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system (link to video here). Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.

  5. A vibro-haptic human-machine interface for structural health monitoring

    SciTech Connect (OSTI)

    Mascarenas, David; Plont, Crystal; Brown, Christina; Cowell, Martin; Jameson, N. Jordan; Block, Jessica; Djidjev, Stephanie; Hahn, Heidi A.; Farrar, Charles

    2014-11-01

    The structural health monitoring (SHM) community’s goal has been to endow physical systems with a nervous system not unlike those commonly found in living organisms. Typically the SHM community has attempted to do this by instrumenting structures with a variety of sensors, and then applying various signal processing and classification procedures to the data in order to detect the presence of damage, the location of damage, the severity of damage, and to estimate the remaining useful life of the structure. This procedure has had some success, but we are still a long way from achieving the performance of nervous systems found in biology. This is primarily because contemporary classification algorithms do not have the performance required. In many cases expert judgment is superior to automated classification. This work introduces a new paradigm. We propose interfacing the human nervous system to the distributed sensor network located on the structure and developing new techniques to enable human-machine cooperation. Results from the field of sensory substitution suggest this should be possible. This study investigates a vibro-haptic human-machine interface for SHM. The investigation was performed using a surrogate three-story structure. The structure features three nonlinearity-inducing bumpers to simulate damage. Accelerometers are placed on each floor to measure the response of the structure to a harmonic base excitation. The accelerometer measurements are preprocessed. As a result, the preprocessed data is then encoded encoded as a vibro-tactile stimulus. Human subjects were then subjected to the vibro-tactile stimulus and asked to characterize the damage in the structure.

  6. A vibro-haptic human-machine interface for structural health monitoring

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mascarenas, David; Plont, Crystal; Brown, Christina; Cowell, Martin; Jameson, N. Jordan; Block, Jessica; Djidjev, Stephanie; Hahn, Heidi A.; Farrar, Charles

    2014-11-01

    The structural health monitoring (SHM) community’s goal has been to endow physical systems with a nervous system not unlike those commonly found in living organisms. Typically the SHM community has attempted to do this by instrumenting structures with a variety of sensors, and then applying various signal processing and classification procedures to the data in order to detect the presence of damage, the location of damage, the severity of damage, and to estimate the remaining useful life of the structure. This procedure has had some success, but we are still a long way from achieving the performance of nervous systemsmore » found in biology. This is primarily because contemporary classification algorithms do not have the performance required. In many cases expert judgment is superior to automated classification. This work introduces a new paradigm. We propose interfacing the human nervous system to the distributed sensor network located on the structure and developing new techniques to enable human-machine cooperation. Results from the field of sensory substitution suggest this should be possible. This study investigates a vibro-haptic human-machine interface for SHM. The investigation was performed using a surrogate three-story structure. The structure features three nonlinearity-inducing bumpers to simulate damage. Accelerometers are placed on each floor to measure the response of the structure to a harmonic base excitation. The accelerometer measurements are preprocessed. As a result, the preprocessed data is then encoded encoded as a vibro-tactile stimulus. Human subjects were then subjected to the vibro-tactile stimulus and asked to characterize the damage in the structure.« less

  7. Notification of Concurrence - K-25/K-27 D&D Project, ETTP - Change Number of EMWMF Waste Lots in the Waste Handling Plan for Demolition of the K-25 and K-27 Building Structures and Remaining Components Located at the ETTP, Oak Ridge, TN From Two to Three

    SciTech Connect (OSTI)

    Trice K.D.

    2009-02-11

    Section 5.1 of the approved Waste Handling Plan for Demolition ofthe K-25 and K-2 7 Building Structures and Remaining Components Located at the East Tennessee Technology Park, Oak Ridge, Tennessee (WHP) includes two Environmental Management Waste Management (EMWMF) waste lots: (1) Asbestos-contaminated roofing/transite; and (2) Construction debris, such as nonasbestos roofing, structural steel/miscellaneous metal/equipment, nonradiological piping, wood, and miscellaneous small quantities of concrete. This concurrence form adds an additional EMWMF waste lot 6.47 for lavatory sink drains. Based on an analysis of the building structure characterization data, the only individual building structure with either an analytic carcinogenic or Hazard Index (HI) sum-of-fractions (SOF) greater than 1 is the lavatory sink drains (Table 1). The HI SOF for the lavatory sink drains is 1.34 (Table 2). When all media are combined with the material of construction calculations, the HI SOF is 1.22 (Table 3). However, when the lavatory sink drains are segregated from all other media, the HI SOF is only 0.256, which is well below the EMWMF waste acceptance criteria SOF limit of 1 (Table 4). Given the large volume (124, 625 cubic yards) of other building structure media with a small HI SOF of 0.256 and the small volume (one cubic yard) of lavatory sink drains with a large HI SOF of 1.34, a separate waste lot for lavatory sink drains is recommended. Lead is the primary contributor to the large HI SOF in the lavatory sink drains. Lead in the lavatory sink drains was shown using the Wilcoxon rank-sum test statistically to have higher concentrations than all other building structure media combined. Other analytes having statistically different median concentrations in the lavatory sink drains compared to all other media are antimony, arsenic, boron, cadmium, selenium, solver, vanadium, zinc, mercury, strontium, and Uranium-233/234 (Table 5). A separate waste lot for the lavatory sink drains

  8. Adapting Human Reliability Analysis from Nuclear Power to Oil and Gas Applications

    SciTech Connect (OSTI)

    Boring, Ronald Laurids

    2015-09-01

    ABSTRACT: Human reliability analysis (HRA), as currently used in risk assessments, largely derives its methods and guidance from application in the nuclear energy domain. While there are many similarities be-tween nuclear energy and other safety critical domains such as oil and gas, there remain clear differences. This paper provides an overview of HRA state of the practice in nuclear energy and then describes areas where refinements to the methods may be necessary to capture the operational context of oil and gas. Many key distinctions important to nuclear energy HRA such as Level 1 vs. Level 2 analysis may prove insignifi-cant for oil and gas applications. On the other hand, existing HRA methods may not be sensitive enough to factors like the extensive use of digital controls in oil and gas. This paper provides an overview of these con-siderations to assist in the adaptation of existing nuclear-centered HRA methods to the petroleum sector.

  9. Expert judgment on markers to deter inadvertent human intrusion into the Waste Isolation Pilot Plant

    SciTech Connect (OSTI)

    Trauth, K.M.; Hora, S.C.; Guzowski, R.V.

    1993-11-01

    The expert panel identified basic principles to guide current and future marker development efforts: (1) the site must be marked, (2) message(s) must be truthful and informative, (3) multiple components within a marker system, (4) multiple means of communication (e.g., language, pictographs, scientific diagrams), (5) multiple levels of complexity within individual messages on individual marker system elements, (6) use of materials with little recycle value, and (7) international effort to maintain knowledge of the locations and contents of nuclear waste repositories. The efficacy of the markers in deterring inadvertent human intrusion was estimated to decrease with time, with the probability function varying with the mode of intrusion (who is intruding and for what purpose) and the level of technological development of the society. The development of a permanent, passive marker system capable of surviving and remaining interpretable for 10,000 years will require further study prior to implementation.

  10. Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor

    SciTech Connect (OSTI)

    López-Sagaseta, Jacinto; Sibener, Leah V.; Kung, Jennifer E.; Gumperz, Jenny; Adams, Erin J.

    2014-10-02

    Invariant Natural Killer T (iNKT) cells use highly restricted {alpha}{beta} T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC) presentation by human CD1d and its recognition by a native, LPC-specific iNKT TCR. Human CD1d presenting LPC adopts an altered conformation from that of CD1d presenting glycolipid antigens, with a shifted {alpha}1 helix resulting in an open A pocket. Binding of the iNKT TCR requires a 7-{angstrom} displacement of the LPC headgroup but stabilizes the CD1d-LPC complex in a closed conformation. The iNKT TCR CDR loop footprint on CD1d-LPC is anchored by the conserved positioning of the CDR3{alpha} loop, whereas the remaining CDR loops are shifted, due in part to amino-acid differences in the CDR3{beta} and J{beta} segment used by this iNKT TCR. These findings provide insight into how lysophospholipids are presented by human CD1d molecules and how this complex is recognized by some, but not all, human iNKT cells.

  11. HSI Prototypes for Human Systems Simulation Laboratory

    SciTech Connect (OSTI)

    Jokstad, Håkon; McDonald, Rob

    2015-09-01

    This report describes in detail the design and features of three Human System Interface (HSI) prototypes developed by the Institutt for Energiteknikk (IFE) in support of the U.S. Department of Energy’s Light Water Reactor Sustainability Program under Contract 128420 through Idaho National Laboratory (INL). The prototypes are implemented for the Generic Pressurized Water Reactor simulator and installed in the Human Systems Simulation Laboratory at INL. The three prototypes are: 1) Power Ramp display 2) RCS Heat-up and Cool-down display 3) Estimated time to limit display The power ramp display and the RCS heat-up/cool-down display are designed to provide good visual indications to the operators on how well they are performing their task compared to their target ramp/heat-up/cool-down rate. The estimated time to limit display is designed to help operators restore levels or pressures before automatic or required manual actions are activated.

  12. Bridging Resilience Engineering and Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring

    2010-06-01

    There has been strong interest in the new and emerging field called resilience engineering. This field has been quick to align itself with many existing safety disciplines, but it has also distanced itself from the field of human reliability analysis. To date, the discussion has been somewhat one-sided, with much discussion about the new insights afforded by resilience engineering. This paper presents an attempt to address resilience engineering from the perspective of human reliability analysis (HRA). It is argued that HRA shares much in common with resilience engineering and that, in fact, it can help strengthen nascent ideas in resilience engineering. This paper seeks to clarify and ultimately refute the arguments that have served to divide HRA and resilience engineering.

  13. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-01-01

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  14. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-12-31

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  15. Justice and the human genome project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.A.

    1995-04-01

    This book is a collection of nine essays originally presented at a conference entitled {open_quotes}Justice and the Human Genome{close_quotes} held in Chicago in late 1991. The goal of the articles in this collection is to explore questions of justice raised by developments in genomic research and by applications of genetic knowledge and technology. The Human Genome Project (HGP) is used as a starting point for exploring these questions, but, as Marc Lappe recognizes, the database generated by HGP research will have implications far beyond the medical applications frequently used to justify this research effort. Thus, the book`s contributors consider questions of justice in relation to screening and testing for various predispositions, conditions, and diseases and gene therapy but also examine testing for other characteristics, forensic uses of genetic information, issues associated with DNA banks, and (hypothetical) genetic enhancement possibilities.

  16. Human Reliability Analysis for Small Modular Reactors

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman

    2012-06-01

    Because no human reliability analysis (HRA) method was specifically developed for small modular reactors (SMRs), the application of any current HRA method to SMRs represents tradeoffs. A first- generation HRA method like THERP provides clearly defined activity types, but these activity types do not map to the human-system interface or concept of operations confronting SMR operators. A second- generation HRA method like ATHEANA is flexible enough to be used for SMR applications, but there is currently insufficient guidance for the analyst, requiring considerably more first-of-a-kind analyses and extensive SMR expertise in order to complete a quality HRA. Although no current HRA method is optimized to SMRs, it is possible to use existing HRA methods to identify errors, incorporate them as human failure events in the probabilistic risk assessment (PRA), and quantify them. In this paper, we provided preliminary guidance to assist the human reliability analyst and reviewer in understanding how to apply current HRA methods to the domain of SMRs. While it is possible to perform a satisfactory HRA using existing HRA methods, ultimately it is desirable to formally incorporate SMR considerations into the methods. This may require the development of new HRA methods. More practicably, existing methods need to be adapted to incorporate SMRs. Such adaptations may take the form of guidance on the complex mapping between conventional light water reactors and small modular reactors. While many behaviors and activities are shared between current plants and SMRs, the methods must adapt if they are to perform a valid and accurate analysis of plant personnel performance in SMRs.

  17. Individual Differences in Human Reliability Analysis

    SciTech Connect (OSTI)

    Jeffrey C. Joe; Ronald L. Boring

    2014-06-01

    While human reliability analysis (HRA) methods include uncertainty in quantification, the nominal model of human error in HRA typically assumes that operator performance does not vary significantly when they are given the same initiating event, indicators, procedures, and training, and that any differences in operator performance are simply aleatory (i.e., random). While this assumption generally holds true when performing routine actions, variability in operator response has been observed in multiple studies, especially in complex situations that go beyond training and procedures. As such, complexity can lead to differences in operator performance (e.g., operator understanding and decision-making). Furthermore, psychological research has shown that there are a number of known antecedents (i.e., attributable causes) that consistently contribute to observable and systematically measurable (i.e., not random) differences in behavior. This paper reviews examples of individual differences taken from operational experience and the psychological literature. The impact of these differences in human behavior and their implications for HRA are then discussed. We propose that individual differences should not be treated as aleatory, but rather as epistemic. Ultimately, by understanding the sources of individual differences, it is possible to remove some epistemic uncertainty from analyses.

  18. Monoamine oxidase: Radiotracer chemistry and human studies

    SciTech Connect (OSTI)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinsons disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.

  19. Monoamine oxidase: Radiotracer chemistry and human studies

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson’s disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variablesmore » which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.« less

  20. Monoamine oxidase: Radiotracer chemistry and human studies

    SciTech Connect (OSTI)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson’s disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.

  1. Current trends in mapping human genes

    SciTech Connect (OSTI)

    Mckusick, V.A. )

    1991-01-01

    The human is estimated to have at least 50,000 expressed genes (gene loci). Some information is available concerning about 5,000 of these gene loci and about 1,900 have been mapped, i.e., assigned to specific chromosomes (and in most instances particular chromosome regions). Progress has been achieved by a combination of physical mapping (e.g., study of somatic cell hybrids and chromosomal in situ hybridization) and genetic mapping (e.g., genetic linkage studies). New methods for both physical and genetic mapping are expanding the armamentarium. The usefulness of the mapping information is already evident; the spin-off from the Human Genome Project (HGP) begins immediately. the complete nucleotide sequence is the ultimate map of the human genome. Sequencing, although already under way for limited segments of the genome, will await further progress in gene mapping, and in particular creation of contig maps for each chromosome. Meanwhile the technology of sequencing and sequence information handling will be developed.

  2. Human-system Interfaces for Automatic Systems

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins,J.; Fleger, S.; Barnes V.

    2010-11-07

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

  3. Preliminary Framework for Human-Automation Collaboration

    SciTech Connect (OSTI)

    Oxstrand, Johanna Helene; Le Blanc, Katya Lee; Spielman, Zachary Alexander

    2015-09-01

    The Department of Energy’s Advanced Reactor Technologies Program sponsors research, development and deployment activities through its Next Generation Nuclear Plant, Advanced Reactor Concepts, and Advanced Small Modular Reactor (aSMR) Programs to promote safety, technical, economical, and environmental advancements of innovative Generation IV nuclear energy technologies. The Human Automation Collaboration (HAC) Research Project is located under the aSMR Program, which identifies developing advanced instrumentation and controls and human-machine interfaces as one of four key research areas. It is expected that the new nuclear power plant designs will employ technology significantly more advanced than the analog systems in the existing reactor fleet as well as utilizing automation to a greater extent. Moving towards more advanced technology and more automation does not necessary imply more efficient and safer operation of the plant. Instead, a number of concerns about how these technologies will affect human performance and the overall safety of the plant need to be addressed. More specifically, it is important to investigate how the operator and the automation work as a team to ensure effective and safe plant operation, also known as the human-automation collaboration (HAC). The focus of the HAC research is to understand how various characteristics of automation (such as its reliability, processes, and modes) effect an operator’s use and awareness of plant conditions. In other words, the research team investigates how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. This report addresses the Department of Energy milestone M4AT-15IN2302054, Complete Preliminary Framework for Human-Automation Collaboration, by discussing the two phased development of a preliminary HAC framework. The framework developed in the first phase was used as the

  4. Human System Simulation in Support of Human Performance Technical Basis at NPPs

    SciTech Connect (OSTI)

    David Gertman; Katya Le Blanc; alan mecham; william phoenix; Magdy Tawfik; Jeffrey Joe

    2010-06-01

    This paper focuses on strategies and progress toward establishing the Idaho National Laboratorys (INLs) Human Systems Simulator Laboratory at the Center for Advanced Energy Studies (CAES), a consortium of Idaho State Universities. The INL is one of the National Laboratories of the US Department of Energy. One of the first planned applications for the Human Systems Simulator Laboratory is implementation of a dynamic nuclear power plant simulation (NPP) where studies of operator workload, situation awareness, performance and preference will be carried out in simulated control rooms including nuclear power plant control rooms. Simulation offers a means by which to review operational concepts, improve design practices and provide a technical basis for licensing decisions. In preparation for the next generation power plant and current government and industry efforts in support of light water reactor sustainability, human operators will be attached to a suite of physiological measurement instruments and, in combination with traditional Human Factors Measurement techniques, carry out control room tasks in simulated advanced digital and hybrid analog/digital control rooms. The current focus of the Human Systems Simulator Laboratory is building core competence in quantitative and qualitative measurements of situation awareness and workload. Of particular interest is whether introduction of digital systems including automated procedures has the potential to reduce workload and enhance safety while improving situation awareness or whether workload is merely shifted and situation awareness is modified in yet to be determined ways. Data analysis is carried out by engineers and scientists and includes measures of the physical and neurological correlates of human performance. The current approach supports a user-centered design philosophy (see ISO 13407 Human Centered Design Process for Interactive Systems, 1999) wherein the context for task performance along with the

  5. PIA - Human Resources System/Payroll System | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    SystemPayroll System PIA - Human Resources SystemPayroll System (291.51 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY ...

  6. Office of Executive Resources Office of the Chief Human Capital...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Executive Resources Office of the Chief Human Capital Officer U.S. Department of ... The request must be submitted to the Office of the Chief Human Capital Officer, Office of ...

  7. Office of Executive Resources Office of the Chief Human Capital...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Executive Resources Office of the Chief Human Capital Officer U.S. Department of ... Chief Human Capital Officer (CHCO) and Office of Executive Resources (OER). (1) Develop ...

  8. The Crystal Structure of Human, Nicotine Metabolizing Cytochrome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Crystal Structure of Human, Nicotine Metabolizing Cytochrome P450 2A6 J.K. Yano1, ... The human cytochrome P450 2A6 is principally involved in the break down of nicotine in the ...

  9. Short-term Human Vision Protection from Intense Light Sources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Short-term Human Vision Protection from Intense Light Sources The primary objective of this invention is to minimize the sensitivity of the human eye to intense visible light by ...

  10. Consortium to design human trials of mosaic HIV vaccine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human trials of mosaic HIV vaccine Consortium to design human trials of mosaic HIV vaccine The vaccine represents a novel strategy for fighting the virus that causes AIDS by ...

  11. BigNeuron: Unlocking the Secrets of the Human Brain

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BigNeuron: Unlocking the Secrets of the Human Brain BigNeuron: Unlocking the Secrets of the Human Brain Berkeley Researchers and Supercomputers to Help Create a Standard 3D Neuron ...

  12. COLLOQUIUM: Human Impacts on the Earth's Geologic Carbon Cycle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 15, 2014, 4:00pm to 5:30pm Colloquia MBG Auditorium COLLOQUIUM: Human Impacts on ... Human Impacts on the Earth's Geologic Carbon Cycle Colloquium Committee: The Princeton ...

  13. Changes in Delegations of Authority from the Office of Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from the Office of Human Capital Management by Jim McDonald Rescinds specific delegation orders that are rescinded as a result of the restructuring of the human capital function ...

  14. Human Resources at Colorado School of Mines | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Employment at Colorado School of Mines Office of Human Resources: 1500 Illinois St., Suite ... Assistant Director (303)-273-3056 Link to Office of Human Resources Link to Job Openings

  15. What Is the Relationship of Electricity and the Human Body? ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Is the Relationship of Electricity and the Human Body? Click to email this to a friend ... What Is the Relationship of Electricity and the Human Body? 2012.05.30 Chief Scientist Jim ...

  16. ATHENA desktop human "body" could reduce need for animal drug...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ATHENA could reduce need for animal drug tests ATHENA desktop human "body" could reduce need for animal drug tests ATHENA project team is developing four human organ constructs that ...

  17. OMB 1910-5122, Human Reliability Program - Description of Collections |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy OMB 1910-5122, Human Reliability Program - Description of Collections OMB 1910-5122, Human Reliability Program - Description of Collections Human Reliability Program Certification (DOE F 470.3). Under the Department of Energy Human Reliability Program (HRP), individuals who are applicants for or incumbents in designated positions must be evaluated to ensure that they meet the requirements for certification in the program. This form documents that each part of the

  18. Chesapeake Habitat for Humanity: Affordable Housing Case Study

    SciTech Connect (OSTI)

    2006-08-28

    This case study describes a partnership with Chesapeake Habitat for Humanity to renovate five Baltimore historic rowhouses.

  19. Human Behavior, Standards and Tools to Improve Design & Operation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Human Behavior, Standards and Tools to Improve Design & Operation Human Behavior, Standards and Tools to Improve Design & Operation Three steps of the technical approach to the human energy behavior loop: (1) Investigate the operations of building energy and services systems through behavior-related data collection, (2) Understand the human behavior through data analytics, data mining, and modeling, and (3) Improve the building performance by applying behavioral

  20. Global environmental change: Modifying human contributions through education

    SciTech Connect (OSTI)

    Carter, L.M.

    1997-12-31

    The 1995 Intergovernmental Panel on Climate Change (IPCC) Science report concludes that evidence now available {open_quotes}points toward a discernible human influence on global climate{close_quotes}. Reductions in emissions will require changes in human behavior. Knowledge, often through education, is an important moderator of human environmental behavior. This study assessed whether gains in global environmental change knowledge would lead to changes in human behaviors that could be deemed environmentally responsible.

  1. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Innovation and Solutions | Department of Energy Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions (1.46 MB) More Documents & Publications PIA - GovTrip (DOE data) LM

  2. Human Portable Radiation Detection System Communications Package Evaluation

    SciTech Connect (OSTI)

    Morgen, Gerald P.; Peterson, William W.

    2009-06-11

    Testing and valuation of the Human Portable Radiation Detection System Communications Package for the US Coast Guard.

  3. Case Study: Southeast Volusia Habitat for Humanity | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Southeast Volusia Habitat for Humanity Case Study: Southeast Volusia Habitat for Humanity Case Study: Southeast Volusia Habitat for Humanity In August 2013, Southeast Volusia County Habitat for Humanity (Volusia Habitat) completed its first U.S. Department of Energy (DOE) Zero Energy Ready Home in Edgewater, on the Atlantic coast of central Florida. This 1,250- ft2, 3-bedroom, 2-bath home achieved a Home Energy Rating System (HERS) score of 49. That is 70 points better than typical existing

  4. PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System (HRMS) | Department of Energy (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) (3.39 MB) More Documents & Publications PIA - Savannah River Nuclear Solution (SRNS) Procurement Cycle System (PCS) PIA - Savannah River Site

  5. Neural and Synaptic Defects in slytherin a Zebrafish Model for Human Congenital Disorders of Glycosylation

    SciTech Connect (OSTI)

    Y Song; J Willer; P Scherer; J Panzer; A Kugath; E Skordalakes; R Gregg; G Willer; R Balice-Gordon

    2011-12-31

    Congenital disorder of glycosylation type IIc (CDG IIc) is characterized by mental retardation, slowed growth and severe immunodeficiency, attributed to the lack of fucosylated glycoproteins. While impaired Notch signaling has been implicated in some aspects of CDG IIc pathogenesis, the molecular and cellular mechanisms remain poorly understood. We have identified a zebrafish mutant slytherin (srn), which harbors a missense point mutation in GDP-mannose 4,6 dehydratase (GMDS), the rate-limiting enzyme in protein fucosylation, including that of Notch. Here we report that some of the mechanisms underlying the neural phenotypes in srn and in CGD IIc are Notch-dependent, while others are Notch-independent. We show, for the first time in a vertebrate in vivo, that defects in protein fucosylation leads to defects in neuronal differentiation, maintenance, axon branching, and synapse formation. Srn is thus a useful and important vertebrate model for human CDG IIc that has provided new insights into the neural phenotypes that are hallmarks of the human disorder and has also highlighted the role of protein fucosylation in neural development.

  6. Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells

    SciTech Connect (OSTI)

    Liu, Xia; Zhao, Libo; Yang, Yongtao; Bode, Liv; Huang, Hua; Liu, Chengyu; Huang, Rongzhong; Zhang, Liang; and others

    2014-09-15

    Background: Borna disease virus (BDV) replicates in the nucleus and establishes persistent infections in mammalian hosts. A human BDV strain was used to address the first time, how BDV infection impacts the proteome and histone lysine acetylation (Kac) of human oligodendroglial (OL) cells, thus allowing a better understanding of infection-driven pathophysiology in vitro. Methods: Proteome and histone lysine acetylation were profiled through stable isotope labeling for cell culture (SILAC)-based quantitative proteomics. The quantifiable proteome was annotated using bioinformatics. Histone acetylation changes were validated by biochemistry assays. Results: Post BDV infection, 4383 quantifiable differential proteins were identified and functionally annotated to metabolism pathways, immune response, DNA replication, DNA repair, and transcriptional regulation. Sixteen of the thirty identified Kac sites in core histones presented altered acetylation levels post infection. Conclusions: BDV infection using a human strain impacted the whole proteome and histone lysine acetylation in OL cells. - Highlights: • A human strain of BDV (BDV Hu-H1) was used to infect human oligodendroglial cells (OL cells). • This study is the first to reveal the host proteomic and histone Kac profiles in BDV-infected OL cells. • BDV infection affected the expression of many transcription factors and several HATs and HDACs.

  7. Human factors issues in qualitative and quantitative safety analyses

    SciTech Connect (OSTI)

    Hahn, H.A.

    1993-10-01

    Humans are a critical and integral part of any operational system, be it a nuclear reactor, a facility for assembly or disassembling hazardous components, or a transportation network. In our concern over the safety of these systems, we often focus our attention on the hardware engineering components of such systems. However, experience has repeatedly demonstrated that it is often the human component that is the primary determinant of overall system safety. Both the nuclear reactor accidents at Chernobyl and Three Mile Island and shipping disasters such as the Exxon Valdez and the Herald of Free Enterprise accidents are attributable to human error. Concern over human contributions to system safety prompts us to include reviews of human factors issues in our safety analyses. In the conduct of Probabilistic Risk Assessments (PRAs), human factors issues are addressed using a quantitative method called Human Reliability Analysis (HRA). HRAs typically begin with the identification of potential sources of human error in accident sequences of interest. Human error analysis often employs plant and/or procedures walk-downs in which the analyst considers the ``goodness`` of procedures, training, and human-machine interfaces concerning their potential contribution to human error. Interviews with expert task performers may also be conducted. In the application of HRA, once candidate sources of human error have been identified, error probabilities are developed.

  8. Assay for mutagenesis in heterozygous diploid human lymphoblasts

    DOE Patents [OSTI]

    Skopek, Thomas R.; Liber, Howard L.; Penman, Bruce W.; Thilly, William G.; Hoppe, IV, Henry

    1981-01-01

    An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.

  9. Trichloroethylene toxicity in a human hepatoma cell line

    SciTech Connect (OSTI)

    Thevenin, E.; McMillian, J.

    1994-12-31

    The experiments conducted in this study were designed to determine the usefullness of hepatocyte cultures and a human hepatoma cell line as model systems for assessing human susceptibility to hepatocellular carcinoma due to exposure to trichloroethylene. The results from these studies will then be analyzed to determine if human cell lines can be used to conduct future experiments of this nature.

  10. PIA - Human Resources - Personal Information Change Request - Idaho

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    National Engineering Laboratory | Department of Energy - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory (278.62 KB) More Documents & Publications PIA - INL

  11. MODELING HUMAN RELIABILITY ANALYSIS USING MIDAS

    SciTech Connect (OSTI)

    Ronald L. Boring; Donald D. Dudenhoeffer; Bruce P. Hallbert; Brian F. Gore

    2006-05-01

    This paper summarizes an emerging collaboration between Idaho National Laboratory and NASA Ames Research Center regarding the utilization of high-fidelity MIDAS simulations for modeling control room crew performance at nuclear power plants. The key envisioned uses for MIDAS-based control room simulations are: (i) the estimation of human error with novel control room equipment and configurations, (ii) the investigative determination of risk significance in recreating past event scenarios involving control room operating crews, and (iii) the certification of novel staffing levels in control rooms. It is proposed that MIDAS serves as a key component for the effective modeling of risk in next generation control rooms.

  12. Human somatic, germinal and heritable mutagenicity

    SciTech Connect (OSTI)

    Mendelsohn, M.L.

    1987-05-01

    This report deals with the general process of variant formation rather than with the consequences of a specific variant being present. It focusses on mutational mechanisms, mutagens, and the method for detecting de novo mutants and estimating mutation rate. It is to human genetics much like disease causation and prevention medicine are to medicine as a whole. The word ''mutagenicity'' is used in the title and throughout the text to connote the causation of all classes of genetic damage. Mutagenicity and the corresponding words mutation, mutagen and mutagenesis can have multiple meaning, sometimes relating to gene mutation, sometimes to heritable mutation, and somtimes to all types of genetic damage. 38 refs., 1 tab.

  13. A novel transcriptional regulator of L-arabinose utilization in human gut bacteria

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chang, Changsoo; Tesar, Christine; Li, Xiaoqing; Kim, Youngchang; Rodionov, Dmitry A.; Joachimiak, Andrzej

    2015-10-04

    We report that carbohydrate metabolism plays a crucial role in the ecophysiology of human gut microbiota. Mechanisms of transcriptional regulation of sugar catabolism in commensal and prevalent human gut bacteria such as Bacteroides thetaiotaomicron remain mostly unknown. By a combination of bioinformatics and experimental approaches, we have identified an NrtR family transcription factor (BT0354 in B. thetaiotaomicron, BtAraR) as a novel regulator controlling the arabinose utilization genes. L-arabinose was confirmed to be a negative effector of BtAraR. We have solved the crystal structures of the apo and L-arabinose-bound BtAraR proteins, as well as the complex of apo-protein with a specificmore » DNA operator. BtAraR forms a homodimer with each subunit comprised of the ligand-binding Nudix hydrolase-like domain and the DNA-binding winged-helix-turn-helix (wHTH) domain. We have identified the residues involved in binding of L-arabinose and recognition of DNA. The majority of these residues are well conserved in the AraR orthologs in Bacteroidetes. In the structure of the BtAraR–DNA complex, we found the unique interaction of arginine intercalating its guanidinum moiety into the base pair stacking of B-DNA. L-arabinose binding induces movement of wHTH domains, resulting in a conformation unsuitable for DNA binding. Furthermore, our analysis facilitates reconstruction of the metabolic and regulatory networks involved in carbohydrate utilization in human gut Bacteroides.« less

  14. A novel transcriptional regulator of L-arabinose utilization in human gut bacteria

    SciTech Connect (OSTI)

    Chang, Changsoo; Tesar, Christine; Li, Xiaoqing; Kim, Youngchang; Rodionov, Dmitry A.; Joachimiak, Andrzej

    2015-10-04

    We report that carbohydrate metabolism plays a crucial role in the ecophysiology of human gut microbiota. Mechanisms of transcriptional regulation of sugar catabolism in commensal and prevalent human gut bacteria such as Bacteroides thetaiotaomicron remain mostly unknown. By a combination of bioinformatics and experimental approaches, we have identified an NrtR family transcription factor (BT0354 in B. thetaiotaomicron, BtAraR) as a novel regulator controlling the arabinose utilization genes. L-arabinose was confirmed to be a negative effector of BtAraR. We have solved the crystal structures of the apo and L-arabinose-bound BtAraR proteins, as well as the complex of apo-protein with a specific DNA operator. BtAraR forms a homodimer with each subunit comprised of the ligand-binding Nudix hydrolase-like domain and the DNA-binding winged-helix-turn-helix (wHTH) domain. We have identified the residues involved in binding of L-arabinose and recognition of DNA. The majority of these residues are well conserved in the AraR orthologs in Bacteroidetes. In the structure of the BtAraR–DNA complex, we found the unique interaction of arginine intercalating its guanidinum moiety into the base pair stacking of B-DNA. L-arabinose binding induces movement of wHTH domains, resulting in a conformation unsuitable for DNA binding. Furthermore, our analysis facilitates reconstruction of the metabolic and regulatory networks involved in carbohydrate utilization in human gut Bacteroides.

  15. Frizzled-8 as a putative therapeutic target in human lung cancer

    SciTech Connect (OSTI)

    Wang, Hua-qing; Department of Medical Oncology, Tianjin Medical University Cancer Hospital, Tianjin 300060 ; Xu, Mei-lin; Ma, Jie; Zhang, Yi; Xie, Cong-hua

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Fzd-8 is over-expressed in human lung cancer. Black-Right-Pointing-Pointer shRNA knock-down of Fzd-8 inhibits proliferation and Wnt pathway in lung cancer cells. Black-Right-Pointing-Pointer shRNA knock-down of Fzd-8 suppresses tumor growth in vivo. Black-Right-Pointing-Pointer shRNA knock-down Fzd-8 sensitizes lung cancer cells to chemotherapy Taxotere. -- Abstract: Lung cancer is the leading cause of cancer related deaths worldwide. It is necessary to better understand the molecular mechanisms involved in lung cancer in order to develop more effective therapeutics for the treatment of this disease. Recent reports have shown that Wnt signaling pathway is important in a number of cancer types including lung cancer. However, the role of Frizzled-8 (Fzd-8), one of the Frizzled family of receptors for the Wnt ligands, in lung cancer still remains to be elucidated. Here in this study we showed that Fzd-8 was over-expressed in human lung cancer tissue samples and cell lines. To investigate the functional importance of the Fzd-8 over-expression in lung cancer, we used shRNA to knock down Fzd-8 mRNA in lung cancer cells expressing the gene. We observed that Fzd-8 shRNA inhibited cell proliferation along with decreased activity of Wnt pathway in vitro, and also significantly suppressed A549 xenograft model in vivo (p < 0.05). Furthermore, we found that knocking down Fzd-8 by shRNA sensitized the lung cancer cells to chemotherapy Taxotere. These data suggest that Fzd-8 is a putative therapeutic target for human lung cancer and over-expression of Fzd-8 may be important for aberrant Wnt activation in lung cancer.

  16. Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

    SciTech Connect (OSTI)

    Erez, Neta; Glanz, Sarah; Raz, Yael; Avivi, Camilla; Barshack, Iris

    2013-08-02

    Highlights: •CAFs in human breast and ovarian tumors express pro-inflammatory factors. •Expression of pro-inflammatory factors correlates with tumor invasiveness. •Expression of pro-inflammatory factors is associated with NF-κb activation in CAFs. -- Abstract: Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also mediate tumor-enhancing inflammation in a mouse model of skin carcinoma. Breast and ovarian carcinomas are amongst the leading causes of cancer-related mortality in women and cancer-related inflammation is linked with both these tumor types. However, the role of CAFs in mediating inflammation in these malignancies remains obscure. Here we show that CAFs in human breast and ovarian tumors express high levels of the pro-inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature. Moreover, we show that both pro-inflammatory signaling by CAFs and leukocyte infiltration of tumors are enhanced in invasive ductal carcinoma as compared with ductal carcinoma in situ. The pro-inflammatory genes expressed by CAFs are known NF-κB targets and we show that NF-κB is up-regulated in breast and ovarian CAFs. Our data imply that CAFs mediate tumor-promoting inflammation in human breast and ovarian tumors and thus may be an attractive target for stromal-directed therapeutics.

  17. A human breast cell model of pre-invasive to invasive transition

    SciTech Connect (OSTI)

    Bissell, Mina J; Rizki, Aylin; Weaver, Valerie M.; Lee, Sun-Young; Rozenberg, Gabriela I.; Chin, Koei; Myers, Connie A.; Bascom, Jamie L.; Mott, Joni D.; Semeiks, Jeremy R.; Grate, Leslie R.; Mian, I. Saira; Borowsky, Alexander D.; Jensen, Roy A.; Idowu, Michael O.; Chen, Fanqing; Chen, David J.; Petersen, Ole W.; Gray, Joe W.; Bissell, Mina J.

    2008-03-10

    A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal characteristics, with invasive cells exhibiting features of higher grade tumors. To find functionally significant changes in transition from pre-invasive to invasive phenotype, we performed attribute profile clustering analysis on the list of genes differentially expressed between pre-invasive and invasive cells. We found integral membrane proteins, transcription factors, kinases, transport molecules, and chemokines to be highly represented. In addition, expression of matrix metalloproteinases MMP-9,-13,-15,-17 was up regulated in the invasive cells. Using siRNA based approaches, we found these MMPs to be required for the invasive phenotype. This model provides a new tool for dissection of mechanisms by which pre-invasive breast cells could acquire invasiveness in a metaplastic context.

  18. Understanding the origins of human cancer

    SciTech Connect (OSTI)

    Alexandrov, L. B.

    2015-12-04

    All cancers originate from a single cell that starts to behave abnormally, to divide uncontrollably, and, eventually, to invade adjacent tissues (1). The aberrant behavior of this single cell is due to somatic mutations—changes in the genomic DNA produced by the activity of different mutational processes (1). These various mutational processes include exposure to exogenous or endogenous mutagens, abnormal DNA editing, the incomplete fidelity of DNA polymerases, and failure of DNA repair mechanisms (2). Early studies that sequenced TP53, the most commonly mutated gene in human cancer, provided evidence that mutational processes leave distinct imprints of somatic mutations on the genome of a cancer cell (3). For example, C:G>A:T transversions predominate in smoking-associated lung cancer, whereas C:G>T:A transitions occurring mainly at dipyrimidines and CC:GG>TT:AA double-nucleotide substitutions are common in ultraviolet light–associated skin cancers. Moreover, these patterns of mutations matched the ones induced experimentally by tobacco mutagens and ultraviolet light, respectively, the major, known, exogenous carcinogenic influences in these cancer types, and demonstrated that examining patterns of mutations in cancer genomes can yield information about the mutational processes that cause human cancer (4).

  19. Structure of Human Ferritin L Chain

    SciTech Connect (OSTI)

    Wang,Z.; Li, C.; Ellenburg, M.; Soistman, E.; Ruble, J.; Wright, B.; Ho, J.; Carter, D.

    2006-01-01

    Ferritin is the major iron-storage protein present in all cells. It generally contains 24 subunits, with different ratios of heavy chain (H) to light chain (L), in the shape of a hollow sphere hosting up to 4500 ferric Fe atoms inside. H-rich ferritins catalyze the oxidation of iron(II), while L-rich ferritins promote the nucleation and storage of iron(III). Several X-ray structures have been determined, including those of L-chain ferritins from horse spleen (HoSF), recombinant L-chain ferritins from horse (HoLF), mouse (MoLF) and bullfrog (BfLF) as well as recombinant human H-chain ferritin (HuHF). Here, structures have been determined of two crystal forms of recombinant human L-chain ferritin (HuLF) obtained from native and perdeuterated proteins. The structures show a cluster of acidic residues at the ferrihydrite nucleation site and at the iron channel along the threefold axis. An ordered Cd{sup 2+} structure is observed within the iron channel, offering further insight into the route and mechanism of iron transport into the capsid. The loop between helices D and E, which is disordered in many other L-chain structures, is clearly visible in these two structures. The crystals generated from perdeuterated HuLF will be used for neutron diffraction studies.

  20. Nucleic acids encoding human trithorax protein

    DOE Patents [OSTI]

    Evans, Glen A.; Djabali, Malek; Selleri, Licia; Parry, Pauline

    2001-01-01

    In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40% amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70% conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.

  1. Understanding the origins of human cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Alexandrov, L. B.

    2015-12-04

    All cancers originate from a single cell that starts to behave abnormally, to divide uncontrollably, and, eventually, to invade adjacent tissues (1). The aberrant behavior of this single cell is due to somatic mutations—changes in the genomic DNA produced by the activity of different mutational processes (1). These various mutational processes include exposure to exogenous or endogenous mutagens, abnormal DNA editing, the incomplete fidelity of DNA polymerases, and failure of DNA repair mechanisms (2). Early studies that sequenced TP53, the most commonly mutated gene in human cancer, provided evidence that mutational processes leave distinct imprints of somatic mutations on themore » genome of a cancer cell (3). For example, C:G>A:T transversions predominate in smoking-associated lung cancer, whereas C:G>T:A transitions occurring mainly at dipyrimidines and CC:GG>TT:AA double-nucleotide substitutions are common in ultraviolet light–associated skin cancers. Moreover, these patterns of mutations matched the ones induced experimentally by tobacco mutagens and ultraviolet light, respectively, the major, known, exogenous carcinogenic influences in these cancer types, and demonstrated that examining patterns of mutations in cancer genomes can yield information about the mutational processes that cause human cancer (4).« less

  2. Science-Based Simulation Model of Human Performance for Human Reliability Analysis

    SciTech Connect (OSTI)

    Dana L. Kelly; Ronald L. Boring; Ali Mosleh; Carol Smidts

    2011-10-01

    Human reliability analysis (HRA), a component of an integrated probabilistic risk assessment (PRA), is the means by which the human contribution to risk is assessed, both qualitatively and quantitatively. However, among the literally dozens of HRA methods that have been developed, most cannot fully model and quantify the types of errors that occurred at Three Mile Island. Furthermore, all of the methods lack a solid empirical basis, relying heavily on expert judgment or empirical results derived in non-reactor domains. Finally, all of the methods are essentially static, and are thus unable to capture the dynamics of an accident in progress. The objective of this work is to begin exploring a dynamic simulation approach to HRA, one whose models have a basis in psychological theories of human performance, and whose quantitative estimates have an empirical basis. This paper highlights a plan to formalize collaboration among the Idaho National Laboratory (INL), the University of Maryland, and The Ohio State University (OSU) to continue development of a simulation model initially formulated at the University of Maryland. Initial work will focus on enhancing the underlying human performance models with the most recent psychological research, and on planning follow-on studies to establish an empirical basis for the model, based on simulator experiments to be carried out at the INL and at the OSU.

  3. HUMAN RELIABILITY ANALYSIS FOR COMPUTERIZED PROCEDURES

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman; Katya Le Blanc

    2011-09-01

    This paper provides a characterization of human reliability analysis (HRA) issues for computerized procedures in nuclear power plant control rooms. It is beyond the scope of this paper to propose a new HRA approach or to recommend specific methods or refinements to those methods. Rather, this paper provides a review of HRA as applied to traditional paper-based procedures, followed by a discussion of what specific factors should additionally be considered in HRAs for computerized procedures. Performance shaping factors and failure modes unique to computerized procedures are highlighted. Since there is no definitive guide to HRA for paper-based procedures, this paper also serves to clarify the existing guidance on paper-based procedures before delving into the unique aspects of computerized procedures.

  4. Mapping genes to human chromosome 19

    SciTech Connect (OSTI)

    Connolly, Sarah

    1996-05-01

    For this project, 22 Expressed Sequence Tags (ESTs) were fine mapped to regions of human chromosome 19. An EST is a short DNA sequence that occurs once in the genome and corresponds to a single expressed gene. {sup 32}P-radiolabeled probes were made by polymerase chain reaction for each EST and hybridized to filters containing a chromosome 19-specific cosmid library. The location of the ESTs on the chromosome was determined by the location of the ordered cosmid to which the EST hybridized. Of the 22 ESTs that were sublocalized, 6 correspond to known genes, and 16 correspond to anonymous genes. These localized ESTs may serve as potential candidates for disease genes, as well as markers for future physical mapping.

  5. Insights from Human/Mouse genome comparisons

    SciTech Connect (OSTI)

    Pennacchio, Len A.

    2003-03-30

    Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

  6. Modeling aspects of human memory for scientific study.

    SciTech Connect (OSTI)

    Caudell, Thomas P.; Watson, Patrick; McDaniel, Mark A.; Eichenbaum, Howard B.; Cohen, Neal J.; Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

    2009-10-01

    Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

  7. Some aspects of statistical modeling of human-error probability

    SciTech Connect (OSTI)

    Prairie, R. R.

    1982-01-01

    Human reliability analyses (HRA) are often performed as part of risk assessment and reliability projects. Recent events in nuclear power have shown the potential importance of the human element. There are several on-going efforts in the US and elsewhere with the purpose of modeling human error such that the human contribution can be incorporated into an overall risk assessment associated with one or more aspects of nuclear power. An effort that is described here uses the HRA (event tree) to quantify and model the human contribution to risk. As an example, risk analyses are being prepared on several nuclear power plants as part of the Interim Reliability Assessment Program (IREP). In this process the risk analyst selects the elements of his fault tree that could be contributed to by human error. He then solicits the HF analyst to do a HRA on this element.

  8. Beyond The Human Genome: What's Next? (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Rokhsar, Daniel

    2014-05-06

    UC Berkeley's Daniel Rokhsar and his colleagues were instrumental in contributing the sequences for three of the human body's chromosomes in the effort to decipher the blueprint of life- the completion of the DNA sequencing of the human genome. Now he is turning to the structure and function of genes in other organisms, some of them no less important to the planet's future than the human map. Hear the latest in this lecture from Lawrence Berkeley National Laboratory.

  9. Office of the Chief Human Capital Officer | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    Human Capital Officer Search Search form Search Office of the Chief Human Capital Officer Office of the Chief Human Capital Officer Services Services Home Benefits Benefits Home DOE Workers' Compensation Program Insurance Military/Reservist Retirement Telework Thrift Savings Plan (TSP) Wellness Programs Executive Resources Learning and Workforce Development New Employee Orientation Policy and Guidance Policy and Guidance Home Compensation Employment/Staffing Employment/Staffing Home Recruitment

  10. Contacts for the Assistant General Counsel for Contractor Human Resources |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Contractor Human Resources Contacts for the Assistant General Counsel for Contractor Human Resources Jean S. Stucky, Assistant General Counsel for Contractor Human Resources 202-586-7532 jean.stucky@hq.doe.gov Eva M. Auman, Attorney-Adviser 202-287-5630 Grant Programs Legacy/Closure Sites Hanford Moab National Energy Testing Laboratory National Renewable Energy Laboratory Pacific Northwest National Laboratory Waste Isolation Pilot Project (Carlsbad Field Office) Thomas

  11. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or

  12. Integrated Human Futures Modeling in Egypt

    SciTech Connect (OSTI)

    Passell, Howard D.; Aamir, Munaf Syed; Bernard, Michael Lewis; Beyeler, Walter E.; Fellner, Karen Marie; Hayden, Nancy Kay; Jeffers, Robert Fredric; Keller, Elizabeth James Kistin; Malczynski, Leonard A.; Mitchell, Michael David; Silver, Emily; Tidwell, Vincent C.; Villa, Daniel; Vugrin, Eric D.; Engelke, Peter; Burrow, Mat; Keith, Bruce

    2016-01-01

    The Integrated Human Futures Project provides a set of analytical and quantitative modeling and simulation tools that help explore the links among human social, economic, and ecological conditions, human resilience, conflict, and peace, and allows users to simulate tradeoffs and consequences associated with different future development and mitigation scenarios. In the current study, we integrate five distinct modeling platforms to simulate the potential risk of social unrest in Egypt resulting from the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile in Ethiopia. The five platforms simulate hydrology, agriculture, economy, human ecology, and human psychology/behavior, and show how impacts derived from development initiatives in one sector (e.g., hydrology) might ripple through to affect other sectors and how development and security concerns may be triggered across the region. This approach evaluates potential consequences, intended and unintended, associated with strategic policy actions that span the development-security nexus at the national, regional, and international levels. Model results are not intended to provide explicit predictions, but rather to provide system-level insight for policy makers into the dynamics among these interacting sectors, and to demonstrate an approach to evaluating short- and long-term policy trade-offs across different policy domains and stakeholders. The GERD project is critical to government-planned development efforts in Ethiopia but is expected to reduce downstream freshwater availability in the Nile Basin, fueling fears of negative social and economic impacts that could threaten stability and security in Egypt. We tested these hypotheses and came to the following preliminary conclusions. First, the GERD will have an important short-term impact on water availability, food production, and hydropower production in Egypt, depending on the short- term reservoir fill rate. Second, the GERD will have a very small impact on

  13. Human Papillomavirus (HPV) Infection in Squamous Cell Carcinomas...

    Office of Scientific and Technical Information (OSTI)

    Human Papillomavirus (HPV) Infection in Squamous Cell Carcinomas Arising From the ... Resource Relation: Journal Name: International Journal of Radiation Oncology, Biology and ...

  14. Genome Wide Evaluation of Normal Human Tissue in Response to...

    Office of Scientific and Technical Information (OSTI)

    Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013 Rocke,...

  15. Sandia Energy - Results from the Human Resilience Index and Modeling...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Results from the Human Resilience Index and Modeling project were reported recently in the National Intelligence Council's Global Trends 2030 Report Home Infrastructure Security...

  16. Building America Case Study: Columbia County Habitat for Humanity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Columbia County Habitat for Humanity Passive Townhomes Hudson, New York PROJECT INFORMATION Project Name: Columbia Passive Townhomes II Location: Hudson, NY Partners: Columbia ...

  17. Creating a Tiny Human Body on a Chip

    ScienceCinema (OSTI)

    Hunsberger, Maren; Soscia, Dave; Moya, Monica

    2016-03-16

    LLNL science communicator Maren Hunsberger takes us "Inside the Lab" to learn about the iChip (In-vitro Chip-based Human Investigational Platform) project at Lawrence Livermore National Laboratory. "One application of the iChip system would be to develop new pharmaceutical drugs," explains Dave Soscia, LLNL postdoc. "When you test in a mouse for example, it's not as close to the human system as you can get. If we can take human cells and put them on devices and actually mimic the structure and function of the organ systems in the human, we can actually replace animal testing and even make a better system for testing pharmaceutical drugs."

  18. Handbook of human-reliability analysis with emphasis on nuclear...

    Office of Scientific and Technical Information (OSTI)

    emphasis on nuclear power plant applications. Final report Citation Details In-Document Search Title: Handbook of human-reliability analysis with emphasis on nuclear power plant ...

  19. Acid soluble platelet aggregating material isolated from human umbilical cord

    DOE Patents [OSTI]

    Schneider, Morris D.

    1983-01-01

    Acid soluble, pepsin sensitive platelet aggregating material isolated from human umbilical cord tissue by extraction with dilute aqueous acid, method of isolation and use to control bleeding.

  20. Columbia County Habitat for Humanity Passive Townhomes (Technical...

    Office of Scientific and Technical Information (OSTI)

    (specifically with respect to exterior wall, space-conditioning, and ventilation strategies) within the labor and budget context inherent in a Habitat for Humanity project. ...

  1. Metabolome of human gut microbiome is predictive of host dysbiosis

    SciTech Connect (OSTI)

    Larsen, Peter E.; Dai, Yang

    2015-09-14

    Background: Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer; a condition called dysbiosis. The community compositions of human microbiomes also vary dramatically from individual to individual, and over time, making it difficult to uncover the underlying mechanisms linking the microbiome to human health. We propose that a microbiome’s interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent on its community metabolome; an emergent property of the microbiome. Results: Using data from a previously published, longitudinal study of microbiome populations of the human gut, we extrapolated information about microbiome community enzyme profiles and metabolome models. Using machine learning techniques, we demonstrated that the aggregate predicted community enzyme function profiles and modeled metabolomes of a microbiome are more predictive of dysbiosis than either observed microbiome community composition or predicted enzyme function profiles. Conclusions: Specific enzyme functions and metabolites predictive of dysbiosis provide insights into the molecular mechanisms of microbiome–host interactions. The ability to use machine learning to predict dysbiosis from microbiome community interaction data provides a potentially powerful tool for understanding the links between the human microbiome and human health, pointing to potential microbiome-based diagnostics and therapeutic interventions.

  2. Massively Parallel Models of the Human Circulatory System (Conference...

    Office of Scientific and Technical Information (OSTI)

    Massively Parallel Models of the Human Circulatory System Citation Details In-Document ... Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 59 ...

  3. DOE human genome program contractor-grantee workshop VI

    SciTech Connect (OSTI)

    1997-10-01

    Research is presented from the workshop on the Human Genome Project. Topics include sequencing, genetic mapping, informatics, ethical and legal issues, and infrastructure.

  4. OSTIblog Articles in the Human Genome Project Topic | OSTI, US...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Related Topics: Charles DeLisi, DNA, DOE Research & Development (R&D) Accomplishments, genomics, Human Genome Project, Santa Fe Workshop, sequencing Read more... DOE Research ...

  5. Metabolome of human gut microbiome is predictive of host dysbiosis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Larsen, Peter E.; Dai, Yang

    2015-09-14

    Background: Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer; a condition called dysbiosis. The community compositions of human microbiomes also vary dramatically from individual to individual, and over time, making it difficult to uncover the underlying mechanisms linking the microbiome to human health. We propose that a microbiome’s interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent onmore » its community metabolome; an emergent property of the microbiome. Results: Using data from a previously published, longitudinal study of microbiome populations of the human gut, we extrapolated information about microbiome community enzyme profiles and metabolome models. Using machine learning techniques, we demonstrated that the aggregate predicted community enzyme function profiles and modeled metabolomes of a microbiome are more predictive of dysbiosis than either observed microbiome community composition or predicted enzyme function profiles. Conclusions: Specific enzyme functions and metabolites predictive of dysbiosis provide insights into the molecular mechanisms of microbiome–host interactions. The ability to use machine learning to predict dysbiosis from microbiome community interaction data provides a potentially powerful tool for understanding the links between the human microbiome and human health, pointing to potential microbiome-based diagnostics and therapeutic interventions.« less

  6. Identifying Requirements for Effective Human-Automation Teamwork

    SciTech Connect (OSTI)

    Jeffrey C. Joe; John O'Hara; Heather D. Medema; Johanna H. Oxstrand

    2014-06-01

    Previous studies have shown that poorly designed human-automation collaboration, such as poorly designed communication protocols, often leads to problems for the human operators, such as: lack of vigilance, complacency, and loss of skills. These problems often lead to suboptimal system performance. To address this situation, a considerable amount of research has been conducted to improve human-automation collaboration and to make automation function better as a “team player.” Much of this research is based on an understanding of what it means to be a good team player from the perspective of a human team. However, the research is often based on a simplified view of human teams and teamwork. In this study, we sought to better understand the capabilities and limitations of automation from the standpoint of human teams. We first examined human teams to identify the principles for effective teamwork. We next reviewed the research on integrating automation agents and human agents into mixed agent teams to identify the limitations of automation agents to conform to teamwork principles. This research resulted in insights that can lead to more effective human-automation collaboration by enabling a more realistic set of requirements to be developed based on the strengths and limitations of all agents.

  7. Structure and mechanism of human DNA polymerase [eta] (Journal...

    Office of Scientific and Technical Information (OSTI)

    DNA polymerase eta Citation Details In-Document ... Here we report high-resolution crystal structures of human ... OSTI Identifier: 1002510 Resource Type: Journal Article ...

  8. Director, Human Resources Shared Service Center (Management and Performance)

    Broader source: Energy.gov [DOE]

    The Office of the Chief Human Capital Officer (OCHCO) is a progressive and contemporary organization that partners with the DOE leadership to maximize the talent, diversity, commitment and...

  9. Building America Case Study: Habitat for Humanity, The Woods...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Type: Single-family, affordable Partners: Tacoma Public Utilities, mytpu.org Habitat for Humanity of Tacoma Pierce County, WA, tpc-habitat.org Building America Partnership for ...

  10. Fluorescent tracking of nickel ions in human cultured cells ...

    Office of Scientific and Technical Information (OSTI)

    Fluorescent tracking of nickel ions in human cultured cells Citation Details In-Document ... B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International ...

  11. Groundwater Resources Assessment under the Pressures of Humanity...

    Open Energy Info (EERE)

    Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Groundwater Resources Assessment under...

  12. Handbook of human-reliability analysis with emphasis on nuclear...

    Office of Scientific and Technical Information (OSTI)

    nuclear power plant applications. Final report Citation Details In-Document Search Title: Handbook of human-reliability analysis with emphasis on nuclear power plant applications. ...

  13. Before House Subcommittee on Africa, Global Health, Global Human...

    Broader source: Energy.gov (indexed) [DOE]

    Testimony of Jonathan Elkind, Acting Assistant Secretary, Office of International Affairs Before House Subcommittee on Africa, Global Health, Global Human Rights, and International ...

  14. First Steps Towards Tribal Weatherization: Human Capacity Development

    Broader source: Energy.gov (indexed) [DOE]

    Towards Tribal Weatherization: Human Capacity Development October 2011 October 2011 Cook Inlet Tribal Council's Weatherization Apprenticeship October 2011 March 2010 - March 2012 ...

  15. First Steps Towards Tribal Weatherization: Human Capacity Development

    Broader source: Energy.gov (indexed) [DOE]

    Steps Towards tribal weatherization: human capacity development October 2010 - Cook Inlet Tribal Council Weatherization Apprenticeship March 2010 February 2012 Cook Inlet Tribal ...

  16. Human Resources at Oak Ridge National Laboratory | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oak Ridge National Laboratory Contact Information The main contact for human resources for CMI at Oak Ridge National Laboratory: David Lett Phone: 865-576-5675 Email: ...

  17. POLICY BULLETIN: POL-5- Declassification Instruction "25X1-human"

    Broader source: Energy.gov [DOE]

    Provides instructions on the appropriate action to take when classification guide topics or source documents cite "25X1-human" declassification instructions.

  18. Human Resources at Lawrence Livermore National Laboratory | Critical...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lawrence Livermore National Laboratory Careers at Lawrence Livermore National Laboratory Main contacts in Human Resources for recruitment and hiring: Jennifer Brizel Recruitment & ...

  19. Human Resources at Critical Materials Institute | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources at Critical Materials Institute Each partner within the Critical Materials Institute manages its own hiring. Use these links to find key contacts for CMI partners ...

  20. Human Resources at Idaho National Laboratory | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Idaho National Laboratory Link to Office of Human Resources INL Staffing (208) 526-5888 Link to infographic on reasons to work at INL

  1. THE NATIONAL CENTER FOR RADIOECOLOGY: A NETWORK OF EXCELLENCE FOR ENVIRONMENTAL AND HUMAN RADIATION RISK REDUCTION

    SciTech Connect (OSTI)

    Jannik, T.

    2013-01-09

    Radioecology in the United States can be traced back to the early 1950s when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a

  2. Human Factors Aspects of Operating Small Reactors

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins, J.; Deem, R.; Xing, J.; DAgostino, A.

    2010-11-07

    The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

  3. Energy Department Issues Remaining $1.8 Billion in Loan Guarantees...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Vogtle project is the first new nuclear power plant to be licensed and begin ... projects including the first nuclear power plant to begin construction in the U.S. in ...

  4. A National Forum on Demand Response: What Remains to Be Done...

    Broader source: Energy.gov (indexed) [DOE]

    Commission's (FERC) staff and the Department of Energy (DOE) jointly submitted to Congress a required "Implementation Proposal for the National Action Plan on DemandResponse." ...

  5. A HIGH-RESOLUTION SPECTROSCOPIC SEARCH FOR THE REMAINING DONOR FOR TYCHO'S SUPERNOVA

    SciTech Connect (OSTI)

    Kerzendorf, Wolfgang E.; Yong, David; Schmidt, Brian P.; Murphy, Simon J.; Bessell, Michael S.; Simon, Joshua D.; Jeffery, C. Simon; Anderson, Jay; Podsiadlowski, Philipp; Gal-Yam, Avishay; Silverman, Jeffrey M.; Filippenko, Alexei V.; Nomoto, Ken'ichi; Venn, Kim A.; Foley, Ryan J.

    2013-09-10

    In this paper, we report on our analysis using Hubble Space Telescope astrometry and Keck-I HIRES spectroscopy of the central six stars of Tycho's supernova remnant (SN 1572). With these data, we measured the proper motions, radial velocities, rotational velocities, and chemical abundances of these objects. Regarding the chemical abundances, we do not confirm the unusually high [Ni/Fe] ratio previously reported for Tycho-G. Rather, we find that for all metrics in all stars, none exhibit the characteristics expected from traditional Type Ia supernova single-degenerate-scenario calculations. The only possible exception is Tycho-B, a rare, metal-poor A-type star; however, we are unable to find a suitable scenario for it. Thus, we suggest that SN 1572 cannot be explained by the standard single-degenerate model.

  6. An evaluation of known remaining oil resources in the United States: Appendix. Volume 10

    SciTech Connect (OSTI)

    1993-11-01

    Volume ten contains the following appendices: overview of improved oil recovery methods which covers enhanced oil recovery methods and advanced secondary recovery methods; the benefits of improved oil recovery, selected data for the analyzed states; and list of TORIS fields and reservoirs.

  7. OM 14-66; Board's Interest Rate Remains 3 Percent for the Fourth...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    However, no case may be in the program for more than 60 days. * The preferred method of conducting settlement conferences is to have the parties or their representatives attend in ...

  8. Contractors Cleaned Up Most of Hanford Site's River Corridor, But Work Remains

    Broader source: Energy.gov [DOE]

    RICHLAND, Wash. – Washington Closure Hanford and previous contractors have completed much of the cleanup work in the River Corridor.

  9. Screening Assessment of Potential Human-Health Risk from Future Natural-Gas Drilling Near Project Rulison in Western Colorado

    SciTech Connect (OSTI)

    Daniels Jeffrey I.,Chapman Jenny B.

    2012-01-01

    The Project Rulison underground nuclear test was conducted in 1969 at a depth of 8,400 ft in the Williams Fork Formation of the Piceance Basin, west-central Colorado (Figure 1). The U.S. Department of Energy Office of Legacy Management (LM) is the steward of the site. Their management is guided by data collected from past site investigations and current monitoring, and by the results of calculations of expected behavior of contaminants remaining in the deep subsurface. The purpose of this screening risk assessment is to evaluate possible health risks from current and future exposure to Rulison contaminants so the information can be factored into LM's stewardship decisions. For example, these risk assessment results can inform decisions regarding institutional controls at the site and appropriate monitoring of nearby natural-gas extraction activities. Specifically, the screening risk analysis can provide guidance for setting appropriate action levels for contaminant monitoring to ensure protection of human health.

  10. Before House Subcommittee on Africa, Global Health, Global Human Rights,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and International Organizations, Committee on Foreign Affairs | Department of Energy House Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations, Committee on Foreign Affairs Before House Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations, Committee on Foreign Affairs Testimony of Jonathan Elkind, Acting Assistant Secretary, Office of International Affairs Before House Subcommittee on Africa, Global Health, Global

  11. Summary of human responses to ventilation

    SciTech Connect (OSTI)

    Seppanen, Olli A.; Fisk, William J.

    2004-06-01

    The effects of ventilation on indoor air quality and health is a complex issue. It is known that ventilation is necessary to remove indoor generated pollutants from indoor air or dilute their concentration to acceptable levels. But, as the limit values of all pollutants are not known, the exact determination of required ventilation rates based on pollutant concentrations and associated risks is seldom possible. The selection of ventilation rates has to be based also on epidemiological research (e.g. Seppanen et al., 1999), laboratory and field experiments (e.g. CEN 1996, Wargocki et al., 2002a) and experience (e.g. ECA 2003). Ventilation may also have harmful effects on indoor air quality and climate if not properly designed, installed, maintained and operated as summarized by Seppdnen (2003). Ventilation may bring indoors harmful substances that deteriorate the indoor environment. Ventilation also affects air and moisture flow through the building envelope and may lead to moisture problems that deteriorate the structures of the building. Ventilation changes the pressure differences over the structures of building and may cause or prevent the infiltration of pollutants from structures or adjacent spaces. Ventilation is also in many cases used to control the thermal environment or humidity in buildings. Ventilation can be implemented with various methods which may also affect health (e.g. Seppdnen and Fisk, 2002, Wargocki et al., 2002a). In non residential buildings and hot climates, ventilation is often integrated with air-conditioning which makes the operation of ventilation system more complex. As ventilation is used for many purposes its health effects are also various and complex. This paper summarizes the current knowledge on positive and negative effects of ventilation on health and other human responses. The focus of the paper is on office-type working environment and residential buildings. In the industrial premises the problems of air quality are usually

  12. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells

    SciTech Connect (OSTI)

    Chen, Tian Jun; Gao, Fei; Yang, Tian; Thakur, Asmitanand; Ren, Hui; Li, Yang; Zhang, Shuo; Wang, Ting; Chen, Ming Wei

    2013-07-19

    Highlights: CDK-associated Cullin 1 (CAC1) expression increases in human lung carcinoma. CAC1 promotes the proliferation of lung cancer A549 cells. CAC1 promotes human lung cancer A549 cell proliferation with activation of ERK1/2. -- Abstract: Lung cancer is one of the most common causes of cancer-related death in the world, but the mechanisms remain unknown. In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest. Furthermore, the proportions of early/late apoptosis in lung cancer A549 cells were enhanced with CAC1 siRNA treatment. It was also found that activation of extracellular signal-regulated protein kinase (ERK) and p38 signaling pathways were involved in the proliferation of A549 cells. After CAC1 siRNA treatment, p-ERK1/2 levels decreased, and meanwhile p-p38 level increased, A549 cell proliferation increased when ERK1/2 signaling is activated by PMA. Our findings demonstrated that CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways, suggesting a potential cure target for treatment of human lung cancer.

  13. Hypoxic remodelling of Ca{sup 2+} stores does not alter human cardiac myofibroblast invasion

    SciTech Connect (OSTI)

    Riches, K.; Hettiarachchi, N.T.; Porter, K.E.; Peers, C.

    2010-12-17

    Research highlights: {yields} Bradykinin promotes migration and proliferation of myofibroblasts. {yields} Such activity is Ca{sup 2+}-dependent and occurs under hypoxic conditions. {yields} Hypoxia increased myofibroblast Ca{sup 2+} stores but not influx evoked by bradykinin. {yields} Myofibroblast migration and proliferation was unaffected by hypoxia. -- Abstract: Cardiac fibroblasts are the most abundant cell type in the heart, and play a key role in the maintenance and repair of the myocardium following damage such as myocardial infarction by transforming into a cardiac myofibroblast (CMF) phenotype. Repair occurs through controlled proliferation and migration, which are Ca{sup 2+} dependent processes, and often requires the cells to operate within a hypoxic environment. Angiotensin converting enzyme (ACE) inhibitors reduce infarct size through the promotion of bradykinin (BK) stability. Although CMF express BK receptors, their activity under the reduced O{sub 2} conditions that occur following infarct are entirely unexplored. Using Fura-2 microfluorimetry on primary human CMF, we found that hypoxia significantly increased the mobilisation of Ca{sup 2+} from intracellular stores in response to BK whilst capacitative Ca{sup 2+} entry (CCE) remained unchanged. The enhanced store mobilisation was due to a striking increase in CMF intracellular Ca{sup 2+}-store content under hypoxic conditions. However, BK-induced CMF migration or proliferation was not affected following hypoxic exposure, suggesting that Ca{sup 2+} influx rather than mobilisation is of primary importance in CMF migration and proliferation.

  14. The Development of A Human Systems Simulation Laboratory: Strategic Direction

    SciTech Connect (OSTI)

    Jacques Hugo; Katya le Blanc; David Gertman

    2012-07-01

    The Human System Simulation Laboratory (HSSL) at the Idaho National Laboratory is one of few facilities of its kind that allows human factors researchers to evaluate various aspects of human performance and human system interaction for proposed reactor designs and upgrades. A basic system architecture, physical configuration and simulation capability were established to enable human factors researchers to support multiple, simultaneous simulations and also different power plant technologies. Although still evolving in terms of its technical and functional architecture, the HSSL is already proving its worth in supporting current and future nuclear industry needs for light water reactor sustainability and small modular reactors. The evolution of the HSSL is focused on continual physical and functional refinement to make it a fully equipped, reconfigurable facility where advanced research, testing and validation studies can be conducted on a wider range of reactor technologies. This requires the implementation of additional plant models to produce empirical research data on human performance with emerging human-system interaction technologies. Additional beneficiaries of this information include system designers and HRA practitioners. To ensure that results of control room crew studies will be generalizable to the existing and evolving fleet of US reactors, future expansion of the HSSL may also include other SMR plant models, plant-specific simulators and a generic plant model aligned to the current generation of pressurized water reactors (PWRs) and future advanced reactor designs. Collaboration with industry partners is also proving to be a vital component of the facility as this helps to establish a formal basis for current and future human performance experiments to support nuclear industry objectives. A long-range Program Plan has been developed for the HSSL to ensure that the facility will support not only the Department of Energys Light Water Reactor

  15. The human LIS1 is downregulated in hepatocellular carcinoma and plays a tumor suppressor function

    SciTech Connect (OSTI)

    Xing, Zhen; Tang, Xin; Gao, Yuan; Da, Liang; Song, Hai; Wang, Suiquan; Tiollais, Pierre; Li, Tsaiping; Zhao, Mujun

    2011-06-03

    Highlights: {yields} LIS1 mRNA and protein levels are decreased in 70% HCC tissues. {yields} Downregulation of LIS1 expression induces oncogenic transformation of QSG7701 and NIH3T3 cells in vitro and in vivo. {yields} LIS1 downregulation leads to mitotic errors including spindle and chromosome defects. {yields} Ectopic expression of LIS1 could significantly inhibit HCC cell proliferation and colony formation. {yields} Our results suggest that LIS1 plays a potential tumor suppressor role in the development and progression of HCC. -- Abstract: The human lissencephaly-1 gene (LIS1) is a disease gene responsible for Miller-Dieker lissencephaly syndrome (MDL). LIS1 gene is located in the region of chromosome 17p13.3 that is frequency deleted in MDL patients and in human liver cancer cells. However, the expression and significance of LIS1 in liver cancer remain unknown. Here, we investigated the expression of LIS1 in hepatocellular carcinoma (HCC) tissues by real-time PCR, Western blot, and immunohistochemistry. The results indicated that the mRNA and protein levels of LIS1 were downregulated in about 70% of HCC tissues, and this downregulation was significantly associated with tumor progression. Functional studies showed that the reduction of LIS1 expression in the normal human liver cell line QSG7701 or the mouse fibroblast cell line NIH3T3 by shRNA resulted in colony formation in soft agar and xenograft tumor formation in nude mice, demonstrating that a decrease in the LIS1 level can promote the oncogenic transformation of cells. We also observed that the phenotypes of LIS1-knockdown cells displayed various defective mitotic structures, suggesting that the mechanism by which reduced LIS1 levels results in tumorigenesis is associated with its role in mitosis. Furthermore, we demonstrated that ectopic expression of LIS1 could significantly inhibit HCC cell proliferation and colony formation. Our results suggest that LIS1 plays a potential tumor suppressor role in the

  16. 99M-technetium labeled macroaggregated human serum albumin pharmaceutical

    DOE Patents [OSTI]

    Winchell, Harry S.; Barak, Morton; Van Fleet, III, Parmer

    1977-05-17

    A reagent comprising macroaggregated human serum albumin having dispersed therein particles of stannous tin and a method for instantly making a labeled pharmaceutical therefrom, are disclosed. The labeled pharmaceutical is utilized in organ imaging.

  17. Habitat for Humanity of Metro Denver Zero Energy Demonstration Home

    SciTech Connect (OSTI)

    Not Available

    2008-04-01

    This brochure describes the 2005 demonstration home designed by NREL and the Habitat for Humanity of Metro Denver. The completed home produced 24% more energy than it consumed over 12 months.

  18. Metabolome of human gut microbiome is predictive of host dysbiosis

    Office of Scientific and Technical Information (OSTI)

    ... Nature. 2014;509(7500):357-60. 48. Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, et al. Longitudinal analysis of microbial interaction between humans and the ...

  19. Human choice and climate change. Volume 1: The societal framework

    SciTech Connect (OSTI)

    Rayner, S.; Malone, E.L.

    1997-12-31

    Foreward: Preface; Introduction; Science and decisionmaking; Population and climate change; Human needs and wants; Cultural discourses; Institutional frameworks for political action; and Sponsoring organizations, International Advisory Board, and project participants.

  20. The sequence and analysis of duplication rich human chromosome 16

    SciTech Connect (OSTI)

    Martin, Joel; Han, Cliff; Gordon, Laurie A.; Terry, Astrid; Prabhakar, Shyam; She, Xinwei; Xie, Gary; Hellsten, Uffe; Man Chan, Yee; Altherr, Michael; Couronne, Olivier; Aerts, Andrea; Bajorek, Eva; Black, Stacey; Blumer, Heather; Branscomb, Elbert; Brown, Nancy C.; Bruno, William J.; Buckingham, Judith M.; Callen, David F.; Campbell, Connie S.; Campbell, Mary L.; Campbell, Evelyn W.; Caoile, Chenier; Challacombe, Jean F.; Chasteen, Leslie A.; Chertkov, Olga; Chi, Han C.; Christensen, Mari; Clark, Lynn M.; Cohn, Judith D.; Denys, Mirian; Detter, John C.; Dickson, Mark; Dimitrijevic-Bussod, Mira; Escobar, Julio; Fawcett, Joseph J.; Flowers, Dave; Fotopulos, Dea; Glavina, Tijana; Gomez, Maria; Gonzales, Eidelyn; Goodstein, David; Goodwin, Lynne A.; Grady, Deborah L.; Grigoriev, Igor; Groza, Matthew; Hammon, Nancy; Hawkins, Trevor; Haydu, Lauren; Hildebrand, Carl E.; Huang, Wayne; Israni, Sanjay; Jett, Jamie; Jewett, Phillip E.; Kadner, Kristen; Kimball, Heather; Kobayashi, Arthur; Krawczyk, Marie-Claude; Leyba, Tina; Longmire, Jonathan L.; Lopez, Frederick; Lou, Yunian; Lowry, Steve; Ludeman, Thom; Mark, Graham A.; Mcmurray, Kimberly L.; Meincke, Linda J.; Morgan, Jenna; Moyzis, Robert K.; Mundt, Mark O.; Munk, A. Christine; Nandkeshwar, Richard D.; Pitluck, Sam; Pollard, Martin; Predki, Paul; Parson-Quintana, Beverly; Ramirez, Lucia; Rash, Sam; Retterer, James; Ricke, Darryl O.; Robinson, Donna L.; Rodriguez, Alex; Salamov, Asaf; Saunders, Elizabeth H.; Scott, Duncan; Shough, Timothy; Stallings, Raymond L.; Stalvey, Malinda; Sutherland, Robert D.; Tapia, Roxanne; Tesmer, Judith G.; Thayer, Nina; Thompson, Linda S.; Tice, Hope; Torney, David C.; Tran-Gyamfi, Mary; Tsai, Ming; Ulanovsky, Levy E.; Ustaszewska, Anna; Vo, Nu; White, P. Scott; Williams, Albert L.; Wills, Patricia L.; Wu, Jung-Rung; Wu, Kevin; Yang, Joan; DeJong, Pieter; Bruce, David; Doggett, Norman; Deaven, Larry; Schmutz, Jeremy; Grimwood, Jane; Richardson, Paul; et al.

    2004-08-01

    We report here the 78,884,754 base pairs of finished human chromosome 16 sequence, representing over 99.9 percent of its euchromatin. Manual annotation revealed 880 protein coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes and 3 RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobasepairs were identified and result in gene content differences across humans. One of the unique features of chromosome 16 is its high level of segmental duplication, ranked among the highest of the human autosomes. While the segmental duplications are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events which are likely to have had an impact on the evolution of primates and human disease susceptibility.

  1. A human reliability analysis of a nuclear explosives dismantlement

    SciTech Connect (OSTI)

    Bott, T.F.

    1995-07-01

    This paper describes the methodology used in a human reliability analysis (HRA) conducted during a quantitative hazard assessment of a nuclear weapon disassembly process performed at the Pantex plant. The probability of human errors during the disassembly process is an extremely important aspect of estimating accident-sequence frequency for nuclear weapons processing. The methods include the systematic identification of potential human-initiated or enabled accident sequences using an accident-sequence fault tree, the extensive use of walkthroughs and videotaping of the disassembly process, and hands-on testing of postulated human errors. THERP modeling of rule-based behavior and operational data analysis of errors in skill-based behavior are described. A simple method for evaluating the approximate likelihood of nonmalevolent violations of procedures was developed and used to examine the process. The HRA occurred concurrently with process design, so considerable interaction between the analysts and designers occurred and resulted in design changes that are discussed in the paper.

  2. Apparatus and methods for a human de-amplifier system

    DOE Patents [OSTI]

    Kress, Reid L.; Jansen, John F.

    2000-01-01

    A human de-amplifier system for interfacing a human operator and a physical object through a physical plant, wherein the physical object has dimensions in the range of 1 micrometer to 1 mm. The human de-amplifier system uses an inner-feedback loop to increases the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human de-amplifier system of the present invention is greatly enhanced over that of the prior art, the de-amplifier system is able to manipulate the physical object has dimensions in the range of 1 micrometer to 1 mm with high stability and accuracy. The system also has a monitoring device to monitor the motion of the physical object under manipulation.

  3. Quantification of the effects of dependence on human error probabiliti...

    Office of Scientific and Technical Information (OSTI)

    In estimating the probabilities of human error in the performance of a series of tasks in a nuclear power plant, the situation-specific characteristics of the series must be ...

  4. Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

    DOE Patents [OSTI]

    Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M.; Theiler, James; Letvin, Norman; Haynes, Barton F.; Hahn, Beatrice H.; Yusim, Karina; Kuiken, Carla

    2012-02-21

    The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

  5. ORS 97 - Rights and Duties Relating to Cemeteries, Human Bodies...

    Open Energy Info (EERE)

    97 - Rights and Duties Relating to Cemeteries, Human Bodies and Anatomical Gifts Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute:...

  6. NMHPD Application for Permit to Excavate Human Burials | Open...

    Open Energy Info (EERE)

    NMHPD Application for Permit to Excavate Human Burials Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: NMHPD Application for Permit...

  7. Confederated Tribes of Warm Springs - Human Capacity Building

    Broader source: Energy.gov (indexed) [DOE]

    Grant DE-PS36-06G096038 Human Capacity Building for Renewable Energy Development. Warm Spring Power and Water Enterprise Mark K. Johnson Jr. Prepared by: Warm Springs Power & Water ...

  8. Chief Human Capital Officer Memo on Improving DOE Recruitment...

    Broader source: Energy.gov (indexed) [DOE]

    Improving DOE Recruitment and Hiring Processes (540.02 KB) Responsible Contacts Kenneth Venuto Director, Office of Human Capital Management E-mail kenneth.venuto@hq.doe.gov More ...

  9. Human Capital: The Role of Ombudsmen in Dispute Resolution |...

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital: The Role of Ombudsmen in Dispute Resolution (339.67 KB) More Documents & Publications The Role of Ombudsmen in Dispute Resolution TT Coordinator Ltr dated May 13 ...

  10. Predicting Human Blood Viscosity in Silico | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Predicting Human Blood Viscosity in Silico Authors: Fedosov., D. A., Pan, W., Caswell, B., Gompper, G., Karniadakis, G.E. The viscosity of blood has long been used as an indicator ...

  11. The Sequence and Analysis of Duplication Rich Human Chromosome 16

    DOE R&D Accomplishments [OSTI]

    Martin, Joel; Han, Cliff; Gordon, Laurie A.; Terry, Astrid; Prabhakar, Shyam; She, Xinwei; Xie, Gary; Hellsten, Uffe; Man Chan, Yee; Altherr, Michael; Couronne, Olivier; Aerts, Andrea; Bajorek, Eva; Black, Stacey; Blumer, Heather; Branscomb, Elbert; Brown, Nancy C.; Bruno, William J.; Buckingham, Judith M.; Callen, David F.; Campbell, Connie S.; Campbell, Mary L.; Campbell, Evelyn W.; Caoile, Chenier; Challacombe, Jean F.; Chasteen, Leslie A.; Chertkov, Olga; Chi, Han C.; Christensen, Mari; Clark, Lynn M.; Cohn, Judith D.; Denys, Mirian; Detter, John C.; Dickson, Mark; Dimitrijevic-Bussod, Mira; Escobar, Julio; Fawcett, Joseph J.; Flowers, Dave; Fotopulos, Dea; Glavina, Tijana; Gomez, Maria; Gonzales, Eidelyn; Goodstein, David; Goodwin, Lynne A.; Grady, Deborah L.; Grigoriev, Igor; Groza, Matthew; Hammon, Nancy; Hawkins, Trevor; Haydu, Lauren; Hildebrand, Carl E.; Huang, Wayne; Israni, Sanjay; Jett, Jamie; Jewett, Phillip E.; Kadner, Kristen; Kimball, Heather; Kobayashi, Arthur; Krawczyk, Marie-Claude; Leyba, Tina; Longmire, Jonathan L.; Lopez, Frederick; Lou, Yunian; Lowry, Steve; Ludeman, Thom; Mark, Graham A.; Mcmurray, Kimberly L.; Meincke, Linda J.; Morgan, Jenna; Moyzis, Robert K.; Mundt, Mark O.; Munk, A. Christine; Nandkeshwar, Richard D.; Pitluck, Sam; Pollard, Martin; Predki, Paul; Parson-Quintana, Beverly; Ramirez, Lucia; Rash, Sam; Retterer, James; Ricke, Darryl O.; Robinson, Donna L.; Rodriguez, Alex; Salamov, Asaf; Saunders, Elizabeth H.; Scott, Duncan; Shough, Timothy; Stallings, Raymond L.; Stalvey, Malinda; Sutherland, Robert D.; Tapia, Roxanne; Tesmer, Judith G.; Thayer, Nina; Thompson, Linda S.; Tice, Hope; Torney, David C.; Tran-Gyamfi, Mary; Tsai, Ming; Ulanovsky, Levy E.; Ustaszewska, Anna; Vo, Nu; White, P. Scott; Williams, Albert L.; Wills, Patricia L.; Wu, Jung-Rung; Wu, Kevin; Yang, Joan; DeJong, Pieter; Bruce, David; Doggett, Norman; Deaven, Larry; Schmutz, Jeremy; Grimwood, Jane; Richardson, Paul; et al.

    2004-01-01

    We report here the 78,884,754 base pairs of finished human chromosome 16 sequence, representing over 99.9 percent of its euchromatin. Manual annotation revealed 880 protein coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes and 3 RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobasepairs were identified and result in gene content differences across humans. One of the unique features of chromosome 16 is its high level of segmental duplication, ranked among the highest of the human autosomes. While the segmental duplications are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events which are likely to have had an impact on the evolution of primates and human disease susceptibility.

  12. Defining Human Failure Events for Petroleum Risk Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring; Knut Øien

    2014-06-01

    In this paper, an identification and description of barriers and human failure events (HFEs) for human reliability analysis (HRA) is performed. The barriers, called target systems, are identified from risk significant accident scenarios represented as defined situations of hazard and accident (DSHAs). This report serves as the foundation for further work to develop petroleum HFEs compatible with the SPAR-H method and intended for reuse in future HRAs.

  13. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  14. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  15. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  16. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  17. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  18. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  19. Solar Energy Education. Humanities: activities and teacher's guide. Field

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    test edition (Technical Report) | SciTech Connect Humanities: activities and teacher's guide. Field test edition Citation Details In-Document Search Title: Solar Energy Education. Humanities: activities and teacher's guide. Field test edition × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional

  20. Human factors engineering report for the cold vacuum drying facility

    SciTech Connect (OSTI)

    IMKER, F.W.

    1999-06-30

    The purpose of this report is to present the results and findings of the final Human Factors Engineering (HFE) technical analysis and evaluation of the Cold Vacuum Drying Facility (CVDF). Ergonomics issues are also addressed in this report, as appropriate. This report follows up and completes the preliminary work accomplished and reported by the Preliminary HFE Analysis report (SNF-2825, Spent Nuclear Fuel Project Cold Vacuum Drying Facility Human Factors Engineering Analysis: Results and Findings). This analysis avoids redundancy of effort except for ensuring that previously recommended HFE design changes have not affected other parts of the system. Changes in one part of the system may affect other parts of the system where those changes were not applied. The final HFE analysis and evaluation of the CVDF human-machine interactions (HMI) was expanded to include: the physical work environment, human-computer interface (HCI) including workstation and software, operator tasks, tools, maintainability, communications, staffing, training, and the overall ability of humans to accomplish their responsibilities, as appropriate. Key focal areas for this report are the process bay operations, process water conditioning (PWC) skid, tank room, and Central Control Room operations. These key areas contain the system safety-class components and are the foundation for the human factors design basis of the CVDF.

  1. "Human-on-a-Chip" Technology Could Replace Animal Testing | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Maren Hunsberger takes us "Inside the Lab" to learn about the "human-on-a-chip" project. | ... viruses, or drugs on human beings without resorting to animal or even human test subjects? ...

  2. Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

    SciTech Connect (OSTI)

    Lingappan, Krithika; Jiang, Weiwu; Wang, Lihua; Couroucli, Xanthi I.; Barrios, Roberto; Moorthy, Bhagavatula

    2013-10-15

    Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO{sub 2} > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F{sub 2} alpha (8-iso-PGF 2α) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2α levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. - Highlights: • Male mice were more susceptible to hyperoxic lung injury than females. • Sex differences in inflammatory markers were observed. • CYP1A expression was higher in females after hyperoxia exposure.

  3. Protection against 2-chloroethyl ethyl sulfide (CEES) - induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway

    SciTech Connect (OSTI)

    Abel, Erika L.; Bubel, Jennifer D.; Simper, Melissa S.; Powell, Leslie; McClellan, S. Alex; Andreeff, Michael; MacLeod, Michael C.; DiGiovanni, John

    2011-09-01

    Sulfur mustard (SM or mustard gas) was first used as a chemical warfare agent almost 100 years ago. Due to its toxic effects on the eyes, lungs, and skin, and the relative ease with which it may be synthesized, mustard gas remains a potential chemical threat to the present day. SM exposed skin develops fluid filled bullae resulting from potent cytotoxicity of cells lining the basement membrane of the epidermis. Currently, there are no antidotes for SM exposure; therefore, chemopreventive measures for first responders following an SM attack are needed. Glutathione (GSH) is known to have a protective effect against SM toxicity, and detoxification of SM is believed to occur, in part, via GSH conjugation. Therefore, we screened 6 potential chemopreventive agents for ability to induce GSH synthesis and protect cultured human keratinocytes against the SM analog, 2-chloroethyl ethyl sulfide (CEES). Using NCTC2544 human keratinocytes, we found that both sulforaphane and methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) stimulated nuclear localization of Nrf2 and induced expression of the GSH synthesis gene, GCLM. Additionally, we found that treatment with CDDO-Me elevated reduced GSH content of NCTC2544 cells and preserved their viability by {approx} 3-fold following exposure to CEES. Our data also suggested that CDDO-Me may act additively with 2,6-dithiopurine (DTP), a nucleophilic scavenging agent, to increase the viability of keratinocytes exposed to CEES. These results suggest that CDDO-Me is a promising chemopreventive agent for SM toxicity in the skin. - Highlights: > CDDO-Me treatment increased intracellular GSH in human keratinocytes. > CDDO-Me increased cell viability following exposure to the half-mustard, CEES. > The cytoprotective effect of CDDO-Me was likely due to scavenging with endogenous GSH.

  4. MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\O~TOR OFFICE b:\HUMAN CAPITAL MANAGEMENT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0 MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\O~TOR OFFICE b:\HUMAN CAPITAL MANAGEMENT SUBJECT: GUIDANCE MEMORANDUM #13 REEMPLOYMENT PRIORITY LIST SELECTIONS This memorandum provides guidance for using the Department of Energy's (DOE) Reemployment Priority List (RPL). The DOE RPL is designed to provide priority consideration to employees who have lost their jobs through reduction in force. or who have fully recovered from a compensable injury after more than 1 year. Employees may only

  5. Crossreactivity of a human autoimmune TCR is dominated by a single...

    Office of Scientific and Technical Information (OSTI)

    Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop Citation Details In-Document Search Title: Crossreactivity of a human autoimmune TCR is dominated ...

  6. MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\\O~TOR OFFICE...

    Broader source: Energy.gov (indexed) [DOE]

    0 MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: SJOTOR OFFICE b:HUMAN CAPITAL MANAGEMENT SUBJECT: GUIDANCE MEMORANDUM 13 REEMPLOYMENT PRIORITY LIST SELECTIONS This memorandum ...

  7. Microsoft Word - DOE Human Capital Strategic Plan 2011-2015.docx

    Broader source: Energy.gov (indexed) [DOE]

    DOE HUMAN CAPITAL STRATEGIC PLAN FY 2011 - FY 2015 DOE HUMAN CAPITAL STRATEGIC PLAN FY 2011 - FY 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY ......

  8. Human Subjects Research Database (HSRD) | U.S. DOE Office of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database (HSRD) Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources CITI Courses DOE ...

  9. For Prospective Human Subjects | U.S. DOE Office of Science ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prospective Human Subjects Human Subjects Protection Program (HSPP) HSPP Home About For Researchers For IRB Managers Administrators For IRB Members For Institutional Officials ...

  10. Human Resources Advisory Office | U.S. DOE Office of Science...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Advisory Office Management OM Home About Program Direction and Analysis Human Resources Advisory Office Administration Contact Information Management U.S. ...

  11. Simulation and Non-Simulation Based Human Reliability Analysis Approaches

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Shirley, Rachel Elizabeth; Joe, Jeffrey Clark; Mandelli, Diego

    2014-12-01

    Part of the U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) Program, the Risk-Informed Safety Margin Characterization (RISMC) Pathway develops approaches to estimating and managing safety margins. RISMC simulations pair deterministic plant physics models with probabilistic risk models. As human interactions are an essential element of plant risk, it is necessary to integrate human actions into the RISMC risk model. In this report, we review simulation-based and non-simulation-based human reliability assessment (HRA) methods. Chapter 2 surveys non-simulation-based HRA methods. Conventional HRA methods target static Probabilistic Risk Assessments for Level 1 events. These methods would require significant modification for use in dynamic simulation of Level 2 and Level 3 events. Chapter 3 is a review of human performance models. A variety of methods and models simulate dynamic human performance; however, most of these human performance models were developed outside the risk domain and have not been used for HRA. The exception is the ADS-IDAC model, which can be thought of as a virtual operator program. This model is resource-intensive but provides a detailed model of every operator action in a given scenario, along with models of numerous factors that can influence operator performance. Finally, Chapter 4 reviews the treatment of timing of operator actions in HRA methods. This chapter is an example of one of the critical gaps between existing HRA methods and the needs of dynamic HRA. This report summarizes the foundational information needed to develop a feasible approach to modeling human interactions in the RISMC simulations.

  12. Assessing human rights impacts in corporate development projects

    SciTech Connect (OSTI)

    Salcito, Kendyl; University of Basel, P.O. Box, CH-4003 Basel; NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202; NewFields, LLC, Denver, CO 80202 ; Utzinger, Jrg; University of Basel, P.O. Box, CH-4003 Basel ; Weiss, Mitchell G.; Mnch, Anna K.; Singer, Burton H.; Krieger, Gary R.; Wielga, Mark; NewFields, LLC, Denver, CO 80202

    2013-09-15

    Human rights impact assessment (HRIA) is a process for systematically identifying, predicting and responding to the potential impact on human rights of a business operation, capital project, government policy or trade agreement. Traditionally, it has been conducted as a desktop exercise to predict the effects of trade agreements and government policies on individuals and communities. In line with a growing call for multinational corporations to ensure they do not violate human rights in their activities, HRIA is increasingly incorporated into the standard suite of corporate development project impact assessments. In this context, the policy world's non-structured, desk-based approaches to HRIA are insufficient. Although a number of corporations have commissioned and conducted HRIA, no broadly accepted and validated assessment tool is currently available. The lack of standardisation has complicated efforts to evaluate the effectiveness of HRIA as a risk mitigation tool, and has caused confusion in the corporate world regarding company duties. Hence, clarification is needed. The objectives of this paper are (i) to describe an HRIA methodology, (ii) to provide a rationale for its components and design, and (iii) to illustrate implementation of HRIA using the methodology in two selected corporate development projectsa uranium mine in Malawi and a tree farm in Tanzania. We found that as a prognostic tool, HRIA could examine potential positive and negative human rights impacts and provide effective recommendations for mitigation. However, longer-term monitoring revealed that recommendations were unevenly implemented, dependent on market conditions and personnel movements. This instability in the approach to human rights suggests a need for on-going monitoring and surveillance. -- Highlights: We developed a novel methodology for corporate human rights impact assessment. We piloted the methodology on two corporate projectsa mine and a plantation. Human rights

  13. Shotgun metaproteomics of the human distal gut microbiota

    SciTech Connect (OSTI)

    VerBerkmoes, N.C.; Russell, A.L.; Shah, M.; Godzik, A.; Rosenquist, M.; Halfvarsson, J.; Lefsrud, M.G.; Apajalahti, J.; Tysk, C.; Hettich, R.L.; Jansson, Janet K.

    2008-10-15

    The human gut contains a dense, complex and diverse microbial community, comprising the gut microbiome. Metagenomics has recently revealed the composition of genes in the gut microbiome, but provides no direct information about which genes are expressed or functioning. Therefore, our goal was to develop a novel approach to directly identify microbial proteins in fecal samples to gain information about the genes expressed and about key microbial functions in the human gut. We used a non-targeted, shotgun mass spectrometry-based whole community proteomics, or metaproteomics, approach for the first deep proteome measurements of thousands of proteins in human fecal samples, thus demonstrating this approach on the most complex sample type to date. The resulting metaproteomes had a skewed distribution relative to the metagenome, with more proteins for translation, energy production and carbohydrate metabolism when compared to what was earlier predicted from metagenomics. Human proteins, including antimicrobial peptides, were also identified, providing a non-targeted glimpse of the host response to the microbiota. Several unknown proteins represented previously undescribed microbial pathways or host immune responses, revealing a novel complex interplay between the human host and its associated microbes.

  14. Interim report of the Advisory Committee on human radiation experiments

    SciTech Connect (OSTI)

    Not Available

    1994-10-21

    The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government`s role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future.

  15. Allometric scaling for predicting human clearance of bisphenol A

    SciTech Connect (OSTI)

    Collet, Séverine H. Picard-Hagen, Nicole Lacroix, Marlène Z. Puel, Sylvie Viguié, Catherine Bousquet-Melou, Alain Toutain, Pierre-Louis Gayrard, Véronique

    2015-05-01

    The investigation of interspecies differences in bisphenol A (BPA) pharmacokinetics (PK) may be useful for translating findings from animal studies to humans, identifying major processes involved in BPA clearance mechanisms, and predicting BPA PK parameters in man. For the first time, a large range of species in terms of body weight, from 0.02 kg (mice) to 495 kg (horses) was used to predict BPA clearance in man by an allometric approach. BPA PK was evaluated after intravenous administration of BPA in horses, sheep, pigs, dogs, rats and mice. A non-compartmental analysis was used to estimate plasma clearance and steady state volume of distribution and predict BPA PK parameters in humans from allometric scaling. In all the species investigated, BPA plasma clearance was high and of the same order of magnitude as their respective hepatic blood flow. By an allometric scaling, the human clearance was estimated to be 1.79 L/min (equivalent to 25.6 mL/kg.min) with a 95% prediction interval of 0.36 to 8.83 L/min. Our results support the hypothesis that there are highly efficient and hepatic mechanisms of BPA clearance in man. - Highlights: • Allometric scaling was used to predict BPA pharmacokinetic parameters in humans. • In all species, BPA plasma clearance approached hepatic blood flow. • Human BPA clearance was estimated to be 1.79 L/min.

  16. Athletic equipment microbiota are shaped by interactions with human skin

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wood, Mariah; Gibbons, Sean M.; Lax, Simon; Eshoo-Anton, Tifani W.; Owens, Sarah M.; Kennedy, Suzanne; Gilbert, Jack A.; Hampton-Marcell, Jarrad T.

    2015-06-19

    Background: Americans spend the vast majority of their lives in built environments. Even traditionally outdoor pursuits, such as exercising, are often now performed indoors. Bacteria that colonize these indoor ecosystems are primarily derived from the human microbiome. The modes of human interaction with indoor surfaces and the physical conditions associated with each surface type determine the steady-state ecology of the microbial community. Results: Bacterial assemblages associated with different surfaces in three athletic facilities, including floors, mats, benches, free weights, and elliptical handles, were sampled every other hour (8 am to 6 pm) for 2 days. Surface and equipment type hadmore » a stronger influence on bacterial community composition than the facility in which they were housed. Surfaces that were primarily in contact with human skin exhibited highly dynamic bacterial community composition and non-random co-occurrence patterns, suggesting that different host microbiomes—shaped by selective forces—were being deposited on these surfaces through time. Bacterial assemblages found on the floors and mats changed less over time, and species co-occurrence patterns appeared random, suggesting more neutral community assembly. Conclusions: These longitudinal patterns highlight the dramatic turnover of microbial communities on surfaces in regular contact with human skin. By uncovering these longitudinal patterns, this study promotes a better understanding of microbe-human interactions within the built environment.« less

  17. IDHEAS – A NEW APPROACH FOR HUMAN RELIABILITY ANALYSIS

    SciTech Connect (OSTI)

    G. W. Parry; J.A Forester; V.N. Dang; S. M. L. Hendrickson; M. Presley; E. Lois; J. Xing

    2013-09-01

    This paper describes a method, IDHEAS (Integrated Decision-Tree Human Event Analysis System) that has been developed jointly by the US NRC and EPRI as an improved approach to Human Reliability Analysis (HRA) that is based on an understanding of the cognitive mechanisms and performance influencing factors (PIFs) that affect operator responses. The paper describes the various elements of the method, namely the performance of a detailed cognitive task analysis that is documented in a crew response tree (CRT), and the development of the associated time-line to identify the critical tasks, i.e. those whose failure results in a human failure event (HFE), and an approach to quantification that is based on explanations of why the HFE might occur.

  18. Recombinant human bone morphogenetic protein induces bone formation

    SciTech Connect (OSTI)

    Wang, E.A.; Rosen, V.; D'Alessandro, J.S.; Bauduy, M.; Cordes, P.; Harada, T.; Israel, D.I.; Hewick, R.M.; Kerns, K.M.; LaPan, P.; Luxenberg, D.P.; McQuaid, D.; Moutsatsos, I.K.; Nove, J.; Wozney, J.M. )

    1990-03-01

    The authors have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 {mu}g of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans.

  19. The Human Genome Initiative of the Department of Energy

    DOE R&D Accomplishments [OSTI]

    1988-01-01

    The structural characterization of genes and elucidation of their encoded functions have become a cornerstone of modern health research, biology and biotechnology. A genome program is an organized effort to locate and identify the functions of all the genes of an organism. Beginning with the DOE-sponsored, 1986 human genome workshop at Santa Fe, the value of broadly organized efforts supporting total genome characterization became a subject of intensive study. There is now national recognition that benefits will rapidly accrue from an effective scientific infrastructure for total genome research. In the US genome research is now receiving dedicated funds. Several other nations are implementing genome programs. Supportive infrastructure is being improved through both national and international cooperation. The Human Genome Initiative of the Department of Energy (DOE) is a focused program of Resource and Technology Development, with objectives of speeding and bringing economies to the national human genome effort. This report relates the origins and progress of the Initiative.

  20. (Meeting on human dimensions of global environmental change)

    SciTech Connect (OSTI)

    Rayner, S.

    1990-12-18

    Traveler attended the meeting of the Standing Committee on the Human Dimensions of Global Environmental Change of the International Social Science Council (ISSC) and the Scientific Symposium organized by the Standing Committee. The purpose of the meeting and symposium was to discuss the Draft Framework and the Workplan of the Standing Committee prior to its presentation to the 1990 Congress of the ISSC on November 28--30, 1990. The meetings indicate that ORNL Global Environmental Studies Center is on the international leading edge of human dimensions research, except in the area of human dimensions data systems. This weakness could be rectified by close collaboration with the efforts of the Consortium for International Earth Science Information Network (CIESIN) in Michigan.

  1. Toxicological and epidemiological aspects of global warming on human health

    SciTech Connect (OSTI)

    Ando, M.; Yamamoto, S.; Wakamatsu, K.; Kawahara, I.; Asanuma, S.

    1996-12-31

    Since human activities are responsible for anthropogenic greenhouse gases emissions, climate models project an increase in the global surface temperature of 0.9 C to 4.0 C by 2100. For human health, it is projected that global warming may have a critical effect on the increased periods of severe heat stress in summer throughout the world. Global warming may have a critical issue on the increased periods of severe heat stress that have a potential impact on peroxidative damage in humans and animals. Lipid peroxidative damage is markedly related to GSH peroxidase activities, therefore the study was carried out to analyze the relationship between biochemical adaptability and the lipid peroxidative damage especially intracellular structure, such as mitochondria and endoplasmic reticulum depending on the exposure time of heat stress.

  2. Continuous human cell lines and method of making same

    DOE Patents [OSTI]

    Stampfer, Martha R.

    1989-01-01

    Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.

  3. Continuous human cell lines and method of making same

    DOE Patents [OSTI]

    Stampfer, M.R.

    1985-07-01

    Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

  4. Understanding mutagenesis through delineation of mutational signatures in human cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Petljak, Mia; Alexandrov, Ludmil B.

    2016-05-04

    Each individual cell within a human body acquires a certain number of somatic mutations during a course of its lifetime. These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational signatures, embedded within the genomes of all cells. In recent years, the vast amount of data produced by sequencing of cancer genomes was coupled with novel mathematical models and computational tools to generate the first comprehensive map of mutational signatures in human cancer. Up to date, >30 distinct mutational signatures have been identified, and etiologies have been proposedmore » for many of them. This paper provides a brief historical background on examination of mutational patterns in human cancer, summarizes the knowledge accumulated since introducing the concept of mutational signatures and discusses their future potential applications and perspectives within the field.« less

  5. Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes

    SciTech Connect (OSTI)

    Lasrich, Dorothee; Bartelt, Alexander; Grewal, Thomas; Heeren, Joerg

    2015-09-10

    Several studies in mice indicate a role for apolipoprotein E (APOE) in lipid accumulation and adipogenic differentiation in adipose tissue. However, little is yet known if APOE functions in a similar manner in human adipocytes. This prompted us to compare lipid loading and expression of adipocyte differentiation markers in APOE-deficient and control adipocytes using the differentiated human mesenchymal stem cell line hMSC-Tert as well as primary human and mouse adipocytes as model systems. Differentiated hMSC-Tert were stably transduced with or without siRNA targeting APOE while murine adipocytes were isolated from wild type and Apoe knockout mice. Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. This correlated with strongly decreased gene expression levels of adipocyte markers such as adiponectin (ADIPOQ) and fatty acid binding protein 4 (FABP4) as well as the key transcription factor driving adipocyte differentiation, peroxisome proliferator activator receptor gamma (PPARG), in particular the PPARG2 isoform. Similarly, differentiation of murine Apoe-deficient adipocytes was characterized by reduced gene expression of Adipoq, Fabp4 and Pparg. Interestingly, incubation of APOE-deficient hMSC-Tert adipocytes with conditioned media from APOE3-overexpressing adipocytes or APOE-containing Very Low Density Lipoprotein (VLDL) partially restored triglyceride accumulation, but were unable to induce adipocyte differentiation, as judged by expression of adipocyte markers. Taken together, depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation, which is associated with an inability to initiate differentiation. - Highlights: • Immortalized human mesenchymal stem cells were used to study adipocyte development. • Knockdown of endogenous APOE lead to impaired lipid accumulation and adipogenesis. • APOE supplementation partially restored lipid accumulation but not differentiation.

  6. Human Factors Considerations in New Nuclear Power Plants: Detailed Analysis.

    SciTech Connect (OSTI)

    OHara,J.; Higgins, J.; Brown, W.; Fink, R.

    2008-02-14

    This Nuclear Regulatory Commission (NRC) sponsored study has identified human-performance issues in new and advanced nuclear power plants. To identify the issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were organized into seven high-level HFE topic areas: Role of Personnel and Automation, Staffing and Training, Normal Operations Management, Disturbance and Emergency Management, Maintenance and Change Management, Plant Design and Construction, and HFE Methods and Tools. The issues where then prioritized into four categories using a 'Phenomena Identification and Ranking Table' methodology based on evaluations provided by 14 independent subject matter experts. The subject matter experts were knowledgeable in a variety of disciplines. Vendors, utilities, research organizations and regulators all participated. Twenty issues were categorized into the top priority category. This Brookhaven National Laboratory (BNL) technical report provides the detailed methodology, issue analysis, and results. A summary of the results of this study can be found in NUREG/CR-6947. The research performed for this project has identified a large number of human-performance issues for new control stations and new nuclear power plant designs. The information gathered in this project can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas through regulatory research. Addressing human-performance issues will provide the technical basis from which regulatory review guidance can be developed to meet these challenges. The availability of this review guidance will help set clear expectations for how the NRC staff will evaluate new designs, reduce regulatory uncertainty, and provide a well-defined path to new nuclear power plant licensing.

  7. In silico prediction of xenobiotic metabolism in humans

    SciTech Connect (OSTI)

    Mu, Fangping

    2009-01-01

    Xenobiotic metabolism in humans is catalyzed by a few enzymes with broad substrate specificities, which provide the overall broad chemical specificity for nearly all xenobiotics that humans encounter. Xenobiotic metabolism are classified into functional group biotransformations. Based on bona fide reactions and negative examples for each reaction class, support vector machine (SVM) classifiers are built. The input to SVM is a set of atomic and molecular features to define the electrostatic, steric, energetic, geometrical and topological environment of the atoms in the reaction center under the molecule. Results show that the overall sensitivity and specificity of classifiers is around 87%.

  8. Accommodating complexity and human behaviors in decision analysis.

    SciTech Connect (OSTI)

    Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan; Strip, David R.; Hirsch, Gary B.; Bastian, Mark S.; Braithwaite, Karl R.; Homer, Jack

    2007-11-01

    This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

  9. Human choice and climate change. Four volume set

    SciTech Connect (OSTI)

    Rayner, S.; Malone, E.L.

    1997-12-31

    The four-volume set assesses social science research relevant to global climate change from a wide-ranging interdisciplinary perspective. Taking human choice within social institutions as the starting point, noted researchers examine climate change issues in the context of societal issues such as population and consumption; cultural, institutional, and economic arrangements for human well-being; and the social processes by which decisions are made from local to global levels. This four-volume assessment is intended to complement the work of the intergovernmental Panel on Climate Change.

  10. THE VALIDITY OF HUMAN AND COMPUTERIZED WRITING ASSESSMENT

    SciTech Connect (OSTI)

    Ronald L. Boring

    2005-09-01

    This paper summarizes an experiment designed to assess the validity of essay grading between holistic and analytic human graders and a computerized grader based on latent semantic analysis. The validity of the grade was gauged by the extent to which the students knowledge of the topic correlated with the graders expert knowledge. To assess knowledge, Pathfinder networks were generated by the student essay writers, the holistic and analytic graders, and the computerized grader. It was found that the computer generated grades more closely matched the definition of valid grading than did human generated grades.

  11. Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana

    SciTech Connect (OSTI)

    Ebinger, M.H.; Hansen, W.R.

    1994-04-29

    The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values were drawn. Sensitivity analyses of the steady-state model showed that the amount of DU in airborne dust and, therefore, the amount of DU on the vegetation surface, controlled the amount of DU ingested by deer and by humans. Human doses from the RESRAD estimates ranged from less than 1 mrem/y to about 6.5 mrem/y in a hunting scenario and subsistence fanning scenario, respectively. The human doses exceeded the 100 mrem/y dose limit when drinking water for the farming scenario was obtained from the on-site aquifer that was presumably contaminated with DU. The two farming scenarios were unrealistic land uses because the additional risk to humans due to unexploded ordnance in the impact area was not figured into the risk estimate. The doses estimated with RESRAD translated to less than 1 {times} 10{sup {minus}6} detriments to about 1 {times} 10{sup {minus}3} detriments. The higher risks were associated only with the farming scenario in which drinking water was obtained on-site.

  12. Ethical issues in international collaborative research on the human genome: The HGP and the HGDP

    SciTech Connect (OSTI)

    Knoppers, B.M.; Hirtle, M.; Lormeau, S.

    1996-06-01

    This special feature describes the ethical issues in international collaborative research on the human genome, both regarding the Human Genome Project (HGP), which is concerned with genetic mapping, and the Human Genome Diversity Project (HGDP), which is an effort to document the genetic variation of the human species worldwide. 88 refs.

  13. Psychosocial and Cultural Modeling in Human Computation Systems: A Gamification Approach

    SciTech Connect (OSTI)

    Sanfilippo, Antonio P.; Riensche, Roderick M.; Haack, Jereme N.; Butner, R. Scott

    2013-11-20

    “Gamification”, the application of gameplay to real-world problems, enables the development of human computation systems that support decision-making through the integration of social and machine intelligence. One of gamification’s major benefits includes the creation of a problem solving environment where the influence of cognitive and cultural biases on human judgment can be curtailed through collaborative and competitive reasoning. By reducing biases on human judgment, gamification allows human computation systems to exploit human creativity relatively unhindered by human error. Operationally, gamification uses simulation to harvest human behavioral data that provide valuable insights for the solution of real-world problems.

  14. The human factors of quality and QA in R D environments

    SciTech Connect (OSTI)

    Hill, S.G.

    1990-01-01

    Achieving quality is a human activity. It is therefore important to consider the human in the design, development and evaluation of work processes and environments in an effort to enhance human performance and minimize error. It is also important to allow for individual differences when considering human factors issues. Human Factors is the field of study which can provide information on integrating the human into the system. Human factors and quality are related for the customer of R D work, R D personnel who perform the work, and the quality professional who overviews the process of quality in the work. 18 refs., 1 fig.

  15. Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro

    SciTech Connect (OSTI)

    Yang, Zi-Rong; Liu, Meng; Peng, Xiu-Lan; Lei, Xiao-Fei; Zhang, Ji-Xiang; Dong, Wei-Guo

    2012-05-11

    Highlights: Black-Right-Pointing-Pointer Noscapine inhibited cell viability of colon cancer in a time- and dose- dependent manner. Black-Right-Pointing-Pointer G{sub 2}/M phase arrest and chromatin condensation and nuclear fragmentation were induced. Black-Right-Pointing-Pointer Noscapine promoted apoptosis via mitochondrial pathways. Black-Right-Pointing-Pointer Tumorigenicity was inhibited by noscapine. -- Abstract: Noscapine, a phthalide isoquinoline alkaloid derived from opium, has been widely used as a cough suppressant for decades. Noscapine has recently been shown to potentiate the anti-cancer effects of several therapies by inducing apoptosis in various malignant cells without any detectable toxicity in cells or tissues. However, the mechanism by which noscapine induces apoptosis in colon cancer cells remains unclear. The signaling pathways by which noscapine induces apoptosis were investigated in colon cancer cell lines treated with various noscapine concentrations for 72 h, and a dose-dependent inhibition of cell viability was observed. Noscapine effectively inhibited the proliferation of LoVo cells in vitro (IC{sub 50} = 75 {mu}M). This cytotoxicity was reflected by cell cycle arrest at G{sub 2}/M and subsequent apoptosis, as indicated by increased chromatin condensation and fragmentation, the upregulation of Bax and cytochrome c (Cyt-c), the downregulation of survivin and Bcl-2, and the activation of caspase-3 and caspase-9. Moreover, in a xenograft tumor model in mice, noscapine injection clearly inhibited tumor growth via the induction of apoptosis, which was demonstrated using a TUNEL assay. These results suggest that noscapine induces apoptosis in colon cancer cells via mitochondrial pathways. Noscapine may be a safe and effective chemotherapeutic agent for the treatment of human colon cancer.

  16. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  17. Human performance modeling for system of systems analytics :soldier fatigue.

    SciTech Connect (OSTI)

    Lawton, Craig R.; Campbell, James E.; Miller, Dwight Peter

    2005-10-01

    The military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives as can be seen in the Department of Defense's (DoD) Defense Modeling and Simulation Office's (DMSO) Master Plan (DoD 5000.59-P 1995). To this goal, the military is currently spending millions of dollars on programs devoted to HPM in various military contexts. Examples include the Human Performance Modeling Integration (HPMI) program within the Air Force Research Laboratory, which focuses on integrating HPMs with constructive models of systems (e.g. cockpit simulations) and the Navy's Human Performance Center (HPC) established in September 2003. Nearly all of these initiatives focus on the interface between humans and a single system. This is insufficient in the era of highly complex network centric SoS. This report presents research and development in the area of HPM in a system-of-systems (SoS). Specifically, this report addresses modeling soldier fatigue and the potential impacts soldier fatigue can have on SoS performance.

  18. Comparative mutagenesis of human cells in vivo and in vitro

    SciTech Connect (OSTI)

    Thilly, W.G.

    1992-05-01

    This report discusses measuring methods of point mutations; high density cell cultures for low dose studies; measurement and sequence determination of mutations in DNA; the mutational spectra of styrene oxide and ethlyene oxide in TK-6 cells; mutational spectrum of Cr in human lymphoblast cells; mutational spectra of radon in TK-6 cells; and the mutational spectra of smokeless tobacco. (CBS)

  19. Human genome program report. Part 1, overview and progress

    SciTech Connect (OSTI)

    1997-11-01

    This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

  20. A Research Roadmap for Computation-Based Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald; Mandelli, Diego; Joe, Jeffrey; Smith, Curtis; Groth, Katrina

    2015-08-01

    The United States (U.S.) Department of Energy (DOE) is sponsoring research through the Light Water Reactor Sustainability (LWRS) program to extend the life of the currently operating fleet of commercial nuclear power plants. The Risk Informed Safety Margin Characterization (RISMC) research pathway within LWRS looks at ways to maintain and improve the safety margins of these plants. The RISMC pathway includes significant developments in the area of thermalhydraulics code modeling and the development of tools to facilitate dynamic probabilistic risk assessment (PRA). PRA is primarily concerned with the risk of hardware systems at the plant; yet, hardware reliability is often secondary in overall risk significance to human errors that can trigger or compound undesirable events at the plant. This report highlights ongoing efforts to develop a computation-based approach to human reliability analysis (HRA). This computation-based approach differs from existing static and dynamic HRA approaches in that it: (i) interfaces with a dynamic computation engine that includes a full scope plant model, and (ii) interfaces with a PRA software toolset. The computation-based HRA approach presented in this report is called the Human Unimodels for Nuclear Technology to Enhance Reliability (HUNTER) and incorporates in a hybrid fashion elements of existing HRA methods to interface with new computational tools developed under the RISMC pathway. The goal of this research effort is to model human performance more accurately than existing approaches, thereby minimizing modeling uncertainty found in current plant risk models.