Powered by Deep Web Technologies
Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994  

SciTech Connect (OSTI)

Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

NONE

1995-05-01T23:59:59.000Z

2

Human radiation studies: Remembering the early years. Oral history of Merril Eisenbud, January 26, 1995  

SciTech Connect (OSTI)

Merril Eisenbud was interviewed on January 26, 1995 by representatives of the US DOE Office of Human Radiation Experiments. Following a brief biographical sketch, Mr. Eisenbud relates his remembrances as the AEC`s first industrial hygienist, the setting up of AEC`s Health and Safety Laboratory, monitoring radioactive fallout, and use or exposure of humans to radiation.

NONE

1995-05-01T23:59:59.000Z

3

Human radiation studies: Remembering the early years. Oral history of biophysicist Cornelius A. Tobias, Ph.D., January 16, 1995  

SciTech Connect (OSTI)

Dr. Cornelius A. Tobias was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). He was chosen for this interview because of his extensive biophysics and medical physics research activities while he was employed by the University of California, Berkeley and San Francisco and at the Donner Laboratory. He discusses his involvement in wartime studies of effects of high altitude on aviators, carbon monoxide with radioactive tracers, blood studies with radioactive iron, human use committees, heavy-ion research with the Bevatron, boron isotope research, classified research involving human subjects, heavy-particle radiography, heavy- particle beams and medical research, and pituitary irradiation studies,.

NONE

1995-07-01T23:59:59.000Z

4

Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995  

SciTech Connect (OSTI)

Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham`s involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others.

NONE

1995-09-01T23:59:59.000Z

5

Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D.  

SciTech Connect (OSTI)

In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project.

NONE

1995-01-18T23:59:59.000Z

6

Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995  

SciTech Connect (OSTI)

NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee.

Fisher, D.; Melamed, E.

1995-07-01T23:59:59.000Z

7

Human radiation studies: Remembering the early years: Oral history of biochemist William D. Moss, conducted November 30, 1994  

SciTech Connect (OSTI)

This report is a transcript of an interview with William D. Moss by representatives of the US DOE Office of Human Radiation Experiments. Mr. Moss was selected for this interview because of his work at Los Alamos National Laboratory concerning analytical methods in the chemical determination of plutonium in biological materials. After a brief biographical sketch, Mr. Moss relates his understanding of how occupational exposure limits were determined for the Manhattan Project, how data from those workers who were exposed to plutonium was collected and analyzed, how the experiments were planned and data was gathered from plutonium or polonium injections in man, how problems with analytical procedures compounded health physics aspects of the project, and problems remaining in the interpretation of these data.

NONE

1995-09-01T23:59:59.000Z

8

Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995  

SciTech Connect (OSTI)

This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory.

NONE

1995-09-01T23:59:59.000Z

9

Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994  

SciTech Connect (OSTI)

This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission`s biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940`s and 1950`s including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities.

NONE

1995-08-01T23:59:59.000Z

10

Whole-body radiation dosimetry of 2-[F-18]fluoro-A-85380 in human PET imaging studies  

E-Print Network [OSTI]

R, Budinger T, Watson E. MIRD Primer for Absorbed DoseInternal Radiation Dose (MIRD) system [28]. To perform thesimplifications inherent in the MIRD phantom model, several

Obrzut, S L; Koren, A O; Mandelkern, M A; Brody, A L; Hoh, C K; London, E D

2005-01-01T23:59:59.000Z

11

Human Portable Radiation Detection System Communications Package Evaluation  

SciTech Connect (OSTI)

Testing and valuation of the Human Portable Radiation Detection System Communications Package for the US Coast Guard.

Morgen, Gerald P.; Peterson, William W.

2009-06-11T23:59:59.000Z

12

Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994  

SciTech Connect (OSTI)

This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists.

NONE

1995-06-01T23:59:59.000Z

13

Human radiation studies: Remembering the early years. Oral history of radiologist Earl R. Miller, M.D., August 9 and 17, 1994  

SciTech Connect (OSTI)

Dr. Earl R. Miller was interviewed by representatives of US DOE Office of Human Radiation Research (OHRE). The interview covers Dr. Miller`s involvement with the Manhattan Engineer District, with total body irradiation, and heavy-ion therapy. Dr. Miller`s remembrances include wartime work on radiation exposure, Joe Hamilton, Neutron Therapy research, means of obtaining isotopes, consent forms, infinite laminograms, invention of a baby holder to alleviate exposure of radiological technicians in diagnostic procedures involving infants, and several personages.

NONE

1995-06-01T23:59:59.000Z

14

Human radiation studies: Remembering the early years: Oral history of medical physicist Katherine L. Lathrop and physician Paul V. Harper, conducted January 26, 1995  

SciTech Connect (OSTI)

This report provides a transcript of an interview with Ms. Katherine L. Lathrop and Dr. Paul V. Hopper by representatives of the DOE Office of Human Radiation Research. Ms. Lathrop and Dr. Hopper were chosen for this interview because of their long-standing interest and research experience in the development of nuclear medicine. After brief biographical sketches the researchers provide a broad and interesting description of their roles in the initial uses of many radiopharmaceuticals, their experiences in human experimentation, and interactions with many other pioneers in nuclear medicine.

NONE

1995-09-01T23:59:59.000Z

15

Human radiation studies: Remembering the early years. Oral history of Dr. John W. Gofman, M.D., Ph.D., December 20, 1994  

SciTech Connect (OSTI)

Dr. John W. Gofman was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE) concerning his research at the University of California, Berkeley and his biomedical work at Lawrence Livermore Radiation Laboratory. Following a short biographical sketch, Dr. Gofman relates his remembrances with the discovery and chemistry of uranium-233, the Manhattan project, laboratory production of the first milligram of plutonium, pre-1945 medical use of high-dosage radiation, medical treatments with phosphorus 32, and fallout. Dr. Gofman also discusses his relationships with Professor Oppenheimer, Joe Hamilton, Ernest Lawrence, and other. Then Dr. Gofman describes his pioneering work on his true interests concerning heart disease, heparin, and lipoproteins. Finally intra-AEC political issues are discussed relating to testing of atomic weapons.

NONE

1995-06-01T23:59:59.000Z

16

Human radiation studies: Remembering the early years: Oral history of health physicist Karl Z. Morgan, Ph.D., conducted January 7, 1995  

SciTech Connect (OSTI)

This report provided a transcript of an interview of Dr. Karl. Z. Morgan by representatives of the DOE Office of Human Radiation Experiments. Dr. Morgan was selected for this interview because of his research for the Manhattan Project at the Metallurgical Laboratory in Chicago and his work at the Oak Ridge National Laboratory (ORNL). The oral history covers Dr. Morgan`s work as a pioneer in the field of Health Physics, his research at ORNL and his work since he retired from ORNL.

NONE

1995-06-01T23:59:59.000Z

17

A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury  

SciTech Connect (OSTI)

Background: Human liver has an unusual sensitivity to radiation that limits its use in cancer therapy or in preconditioning for hepatocyte transplantation. Because the characteristic veno-occlusive lesions of radiation-induced liver disease do not occur in rodents, there has been no experimental model to investigate the limits of safe radiation therapy or explore the pathogenesis of hepatic veno-occlusive disease. Methods and Materials: We performed a dose-escalation study in a primate, the cynomolgus monkey, using hypofractionated stereotactic body radiotherapy in 13 animals. Results: At doses ?40 Gy, animals developed a systemic syndrome resembling human radiation-induced liver disease, consisting of decreased albumin, elevated alkaline phosphatase, loss of appetite, ascites, and normal bilirubin. Higher radiation doses were lethal, causing severe disease that required euthanasia approximately 10 weeks after radiation. Even at lower doses in which radiation-induced liver disease was mild or nonexistent, latent and significant injury to hepatocytes was demonstrated by asialoglycoprotein-mediated functional imaging. These monkeys developed hepatic failure with encephalopathy when they received parenteral nutrition containing high concentrations of glucose. Histologically, livers showed central obstruction via an unusual intimal swelling that progressed to central fibrosis. Conclusions: The cynomolgus monkey, as the first animal model of human veno-occlusive radiation-induced liver disease, provides a resource for characterizing the early changes and pathogenesis of venocclusion, for establishing nonlethal therapeutic dosages, and for examining experimental therapies to minimize radiation injury.

Yannam, Govardhana Rao [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Han, Bing [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi (China); Setoyama, Kentaro [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamamoto, Toshiyuki [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Ito, Ryotaro; Brooks, Jenna M. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Guzman-Lepe, Jorge [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Galambos, Csaba [Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Fong, Jason V. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Deutsch, Melvin; Quader, Mubina A. [Department of Radiation Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamanouchi, Kosho [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York (United States); Kabarriti, Rafi; Mehta, Keyur [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Soto-Gutierrez, Alejandro [Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); and others

2014-02-01T23:59:59.000Z

18

RADIATION PERMIT APPLICATION Western Human Resources  

E-Print Network [OSTI]

and Model of Radiation Device (if applicable) Experimental Protocol Describe in detail your experimental the aspects that pertain to safety issues, describe any special hazards, and include the following: 1. Brief will be performed 7. Provide a waste disposal flow chart indicating approx. activities (mCi or MBq) for each type

Sinnamon, Gordon J.

19

X radiation and the human fetus - a bibliography. Final report  

SciTech Connect (OSTI)

The bibliography is the end result of many years' survey of the literature pertaining to the effects of ionizing radiation, particularly x radiation, on the human embryo and fetus. It is intended to provide the technical and scientific community with a ready identification of material available to them in this discipline. It is divided into three sections: an index (KWIC) by keywords, an author list, and the bibliography.

Rugh, R.

1980-03-01T23:59:59.000Z

20

Synchrotron radiation identified human chemical fingerprints a novel forensic approach  

E-Print Network [OSTI]

Synchrotron radiation identified human chemical fingerprints ­ a novel forensic approach T with the goal of developing an advanced forensic technique to identify complicated partial latent prints a forensic analysis of the fingerprint chemistry, or to identify the latent prints of pre-pubescent children

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Dosimetry for quantitative analysis of low dose ionizing radiation effects on humans in radiation therapy patients  

SciTech Connect (OSTI)

We have successfully developed a practical approach to predicting the location of skin surface dose at potential biopsy sites that receive 1 cGy and 10 cGy, respectively, in support of in vivo biologic dosimetry in humans. This represents a significant technical challenge as the sites lie on the patient surface out side the radiation fields. The PEREGRINE Monte Carlo simulation system was used to model radiation dose delivery and TLDs were used for validation on a phantom and confirmation during patient treatment. In the developmental studies the Monte Carlo simulations consistently underestimated the dose at the biopsy site by approximately 15% for a realistic treatment configuration, most likely due to lack of detail in the simulation of the linear accelerator outside the main beam line. Using a single, thickness-independent correction factor for the clinical calculations, the average of 36 measurements for the predicted 1 cGy point was 0.985 cGy (standard deviation: 0.110 cGy) despite patient breathing motion and other real world challenges. Since the 10 cGy point is situated in the region of high dose gradient at the edge of the field, patient motion had a greater effect and the six measured points averaged 5.90 cGy (standard deviation: 1.01 cGy), a difference that is equivalent to approximately a 6 mm shift on the patient's surface.

Lehmann, J; Stern, R L; Daly, T P; Schwieter, C W; Jones, G E; Arnold, M L; Hartmann-Siantar, C L; Goldberg, Z

2004-04-20T23:59:59.000Z

22

Advisory Committee on human radiation experiments final report  

SciTech Connect (OSTI)

When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

NONE

1995-10-01T23:59:59.000Z

23

Human radiation experiments associated with the US Department of Energy and its predecessors  

SciTech Connect (OSTI)

This document contains a listing, description, and selected references for documented human radiation experiments sponsored, supported, or performed by the US Department of Energy (DOE) or its predecessors, including the US Energy Research and Development Administration (ERDA), the US Atomic Energy Commission (AEC), the Manhattan Engineer District (MED), and the Off ice of Scientific Research and Development (OSRD). The list represents work completed by DOE`s Off ice of Human Radiation Experiments (OHRE) through June 1995. The experiment list is available on the Internet via a Home Page on the World Wide Web (http://www.ohre.doe.gov). The Home Page also includes the full text of Human Radiation Experiments. The Department of Energy Roadmap to the Story and the Records (DOE/EH-0445), published in February 1995, to which this publication is a supplement. This list includes experiments released at Secretary O`Leary`s June 1994 press conference, as well as additional studies identified during the 12 months that followed. Cross-references are provided for experiments originally released at the press conference; for experiments released as part of The DOE Roadmap; and for experiments published in the 1986 congressional report entitled American Nuclear Guinea Pigs: Three Decades of Radiation Experiments on US Citizens. An appendix of radiation terms is also provided.

None

1995-07-01T23:59:59.000Z

24

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

E-Print Network [OSTI]

R.B. Mikkelsen, Ionizing radiation-induced, mitochondria-W.K. Rorrer, P.B. Chen, Radiation-induced proliferation ofresponse genes to ionizing radiation in human lymphoblastoid

Wyrobek, A. J.

2011-01-01T23:59:59.000Z

25

HUMAN RADIATION STUDIES: REMEMBERING THE EARLY YEARS  

Office of Scientific and Technical Information (OSTI)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinan antagonist Journal Article: Crystal structureComposite--FORRemarksHEATING DISTRIBUTIONS INDOBEH -0454

26

237Poverty and Human Capability Studies Poverty and Human  

E-Print Network [OSTI]

237Poverty and Human Capability Studies Poverty and Human CaPability StudieS (Pov) Core FaCulty: PROFESSORS beCKley*, GOLDSMITH, MARGAND The Shepherd Program for the interdisciplinary Study of Poverty and graduate studies can prepare them as futureprofessionalsandcitizenstoaddresstheproblems of poverty and how

Dresden, Gregory

27

227Poverty and Human Capability Studies Poverty AND HUMAN  

E-Print Network [OSTI]

227Poverty and Human Capability Studies Poverty AND HUMAN CAPABILIty StUDIeS (Pov) Core FACULty: PROFESSORS BeCKLey*, GOLDSMITH, MARGAND The Shepherd Program for the Interdisciplinary Study of Poverty studies can prepare them as future professionals and citizens to address the problems of poverty

Dresden, Gregory

28

Human radiation experiments: The Department of Energy roadmap to the story and the records  

SciTech Connect (OSTI)

The role of the US Government in conducting or sponsoring human radiation experiments has become the subject of public debate. Questions have been raised about the purpose, extent, and health consequences of these studies, and about how subjects were selected. The extent to which subjects provided informed consent is also under scrutiny. To respond to these questions, the Clinton administration has directed the US Department of Energy (DOE), along with other Federal agencies, to retrieve and inventory all records that document human radiation experiments. Many such records are now publicly available and will permit an open accounting and understanding of what took place. This report summarizes the Department`s ongoing search for records about human radiation experiments. It is also a roadmap to the large universe of pertinent DOE information. DOE is working to instill greater openness--consistent with national security and other appropriate considerations--throughout its operations. A key aspect of this effort is opening DOE`s historical records to independent research and analysis.

Not Available

1995-02-01T23:59:59.000Z

29

Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures  

SciTech Connect (OSTI)

Purpose: We investigated the effects of fractionated radiation treatments on the life spans of athymic rats bearing intracerebral brain tumors. Methods and Materials: U-251 MG or U-87 MG human glioblastoma cells were implanted into the brains of athymic rats, and the resulting tumors were irradiated once daily with various doses of ionizing radiation for 5 consecutive days or for 10 days with a 2-day break after Day 5. Results: Five daily doses of 1 and 1.5 Gy, and 10 doses of 0.75 and 1 Gy, cured some U-251 MG tumors. However, five daily doses of 0.5 Gy increased the survival time of animals bearing U-251 MG tumors 5 days without curing any animals of their tumors. Ten doses of 0.3 Gy given over 2 weeks extended the lifespan of the host animals 9 days without curing any animals. For U-87 MG tumors, 5 daily doses of 3 Gy produced an increased lifespan of 8 days without curing any animals, and 10 doses of 1 Gy prolonged lifespan 5.5 days without curing any animals. The differences in extension of life span between the 5- and 10-fraction protocols were minor for either tumor type. Conclusion: The finding that the U-251 MG tumors are more sensitive than U-87 MG tumors, despite the fact that U-251 MG tumors contain many more hypoxic cells than U-87 MG tumors, suggests the intrinsic cellular radiosensitivities of these cell lines are more important than hypoxia in determining their in vivo radiosensitivities.

Ozawa, Tomoko [Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (United States); Faddegon, Bruce A. [Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (United States); Hu, Lily J. [Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (United States); Bollen, Andrew W. [Department of Pathology, University of California San Francisco, San Francisco, CA (United States); Lamborn, Kathleen R. [Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (United States); Deen, Dennis F. [Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (United States) and Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (United States)]. E-mail: ddeen@itsa.ucsf.edu

2006-09-01T23:59:59.000Z

30

Experimental and Computational Studies of Electric Thruster Plasma Radiation Emission  

E-Print Network [OSTI]

Experimental and Computational Studies of Electric Thruster Plasma Radiation Emission Murat Celik Thruster Plasma Radiation Emission by Murat C¸elik B.S., Aerospace Engineering and Physics, University;Experimental and Computational Studies of Electric Thruster Plasma Radiation Emission by Murat C¸elik Submitted

31

Tryptophan Cluster Protects Human ?D-Crystallin from Ultraviolet Radiation-Induced Photoaggregation  

E-Print Network [OSTI]

Exposure to ultraviolet radiation (UVR) is a significant risk factor for age-related cataract, a disease of the human lens and the most prevalent cause of blindness in the world. Cataract pathology involves protein misfolding ...

Schafheimer, Steven Nathaniel

32

Radiation worker health study: Scoping phase: Final report  

SciTech Connect (OSTI)

The purpose of this project was to develop a scope of work for an epidemiologic study of the health of workers at nuclear utilities. We propose a study of cancer mortality among electric utility personnel assigned to nuclear generating stations. The primary goal of the study is to provide information to assist in maintaining a healthy work environment in electric utilities; such information would also help to resolve some uncertainties about the effects of low-level ionizing radiation by providing direct observation of human beings exposed at low doses and dose rates. Workers at each nuclear generating station would be identified from company records, their dose histories would be collected, and their vital status would be ascertained as well as cause of death, if deceased. This study would be historical in that past records would be used and prospective in that employees would continue to be followed in future years. Our estimates indicate that a study population composed of employees and contractors at all commercial nuclear generating stations would total approximately 2,000,000 person-years of observation and would be adequate to detect (or exclude) a 50 percent increase in leukemia with reasonable statistical power. 44 refs., 4 figs., 3 tabs.

Dreyer, N.A.; Wilkinson, G.S.; Loughlin, J.E.

1988-11-01T23:59:59.000Z

33

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

SciTech Connect (OSTI)

We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

2011-04-18T23:59:59.000Z

34

Power line harmonic radiation: A systematic study using DEMETER spacecraft  

E-Print Network [OSTI]

Power line harmonic radiation: A systematic study using DEMETER spacecraft F. Nemec a,b,*, O of a systematic survey of Power line harmonic radiation (PLHR) observed by the DEMETER spacecraft. DEME- TER frequency spacing corresponds well to the power system frequency at anticipated source locations. Moreover

Santolik, Ondrej

35

Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report  

SciTech Connect (OSTI)

This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note.

NONE

1995-01-01T23:59:59.000Z

36

Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [11  

E-Print Network [OSTI]

was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeysWhole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 in the anteroposterior direction. Results: Effective dose was 4.8 Gy/MBq based on 2D planar images. The effective dose

Shen, Jun

37

Human In vivo Dose-Response to Controlled, Low-Dose Low Linear EnergyTransfer Ionizing Radiation Exposure  

E-Print Network [OSTI]

Human In vivo Dose-Response to Controlled, Low-Dose Low Linear EnergyTransfer Ionizing Radiation Purpose: The effect of low doses of low ^ linear energy transfer (photon) ionizing radiation (LDIR, and pathway. Conclusions: These results show for the first time that low doses of radiation have an identifi

Rocke, David M.

38

French Studies The School of Humanities  

E-Print Network [OSTI]

1 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

39

French Studies The School of Humanities  

E-Print Network [OSTI]

181 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

40

French Studies The School of Humanities  

E-Print Network [OSTI]

164 French Studies The School of Humanities Chair Bernard Aresu Professors Madeleine Alcover Jean in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, histori- cal, philosophical, and theoretical concerns. Students

Richards-Kortum, Rebecca

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

French Studies The School of Humanities  

E-Print Network [OSTI]

of French literature within a broad spectrum of cultural, histori- cal, philosophical, and theoretical179 French Studies The School of Humanities Chair Michel Achard Professors Madeleine Alcover.D. Courses in this department hone language skills in French while placing a diverse, generalized knowledge

Richards-Kortum, Rebecca

42

French Studies The School of Humanities  

E-Print Network [OSTI]

174 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical,philosophical,and theoretical concerns.Students are also

Richards-Kortum, Rebecca

43

French Studies The School of Humanities  

E-Print Network [OSTI]

189 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

44

French Studies The School of Humanities  

E-Print Network [OSTI]

176 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical,philosophical,and theoretical concerns.Students are also

Richards-Kortum, Rebecca

45

American Society for Radiation Oncology (ASTRO) 2012 Workforce Study: The Radiation Oncologists' and Residents' Perspectives  

SciTech Connect (OSTI)

Purpose: The American Society for Radiation Oncology (ASTRO) conducted the 2012 Radiation Oncology Workforce Survey to obtain an up-to-date picture of the workforce, assess its needs and concerns, and identify quality and safety improvement opportunities. The results pertaining to radiation oncologists (ROs) and residents (RORs) are presented here. Methods: The ASTRO Workforce Subcommittee, in collaboration with allied radiation oncology professional societies, conducted a survey study in early 2012. An online survey questionnaire was sent to all segments of the radiation oncology workforce. Respondents who were actively working were included in the analysis. This manuscript describes the data for ROs and RORs. Results: A total of 3618 ROs and 568 RORs were surveyed. The response rate for both groups was 29%, with 1047 RO and 165 ROR responses. Among ROs, the 2 most common racial groups were white (80%) and Asian (15%), and the male-to-female ratio was 2.85 (74% male). The median age of ROs was 51. ROs averaged 253.4 new patient consults in a year and 22.9 on-treatment patients. More than 86% of ROs reported being satisfied or very satisfied overall with their career. Close to half of ROs reported having burnout feelings. There was a trend toward more frequent burnout feelings with increasing numbers of new patient consults. ROs' top concerns were related to documentation, reimbursement, and patients' health insurance coverage. Ninety-five percent of ROs felt confident when implementing new technology. Fifty-one percent of ROs thought that the supply of ROs was balanced with demand, and 33% perceived an oversupply. Conclusions: This study provides a current snapshot of the 2012 radiation oncology physician workforce. There was a predominance of whites and men. Job satisfaction level was high. However a substantial fraction of ROs reported burnout feelings. Perceptions about supply and demand balance were mixed. ROs top concerns reflect areas of attention for the healthcare sector as a whole.

Pohar, Surjeet, E-mail: spohar@iuhealth.org [Indiana University Health East, Indianapolis, Indiana (United States); Fung, Claire Y. [Commonwealth Newburyport Cancer Center, Newburyport, Massachusetts (United States); Hopkins, Shane [William R. Bliss Cancer Center, Ames, Iowa (United States); Miller, Robert [Mayo Clinic, Rochester, Minnesota (United States); Azawi, Samar [VA Veteran Hospital/University of California Irvine, Newport Beach, California (United States); Arnone, Anna; Patton, Caroline [ASTRO, Fairfax, Virginia (United States); Olsen, Christine [Massachusetts General Hospital, Boston, Massachusetts (United States)

2013-12-01T23:59:59.000Z

46

Experimental studies of radiation damage of silicon detectors. Internal report  

SciTech Connect (OSTI)

New particle physics experiments are correlated with high luminosity and/or high energy. The new generation of colliding beam machines which will be constructed will make an extrapolation of a factor of 100 in the center of mass energy and of 1000 in luminosity beyond present accelerators. The scientific community hopes that very exciting physics results could be achieved this way, from the solution to the problem of electroweak symmetry breaking to the possible discovery of new, unpredicted phenomena. The particles which compose the radiation field are: electrons, pions, neutrons, protons and photons. It has become evident that the problem of the radiation resistance of detectors in this severe environment is a crucial one. This situation is complicated more by the fact that detectors must work all the run time of the machine, and better all the time of the experiment, without replacement (part or whole). So, studies related to the investigation of the radiation hardness of all detector parts, are developing. The studies are in part material and device characterization after irradiation, and in part technological developments, made in order to find harder, cheaper technologies, for larger surfaces. Semiconductor detectors have proven to be a good choice for vertex and calorimeter. Both fixed target machines and colliders had utilized in the past silicon junction detectors as the whole or part of the detection system. Precision beam hodoscopes and sophisticated trigger devices with silicon are equally used. The associated electronics in located near the detectors, and is subjected to the same radiation fields. Studies of material and device radiation hardness are developing in parallel. Here the authors present results on the radiation hardness of silicon, both as a bulk material and as detectors, to neutron irradiation at high fluences.

Angelescu, T.; Ghete, V.M.; Ghiordanescu, N.; Lazanu, I.; Mihul, A. [Univ. of Bucharest (Romania); Golutvin, I.; Lazanu, S.; Savin, I.; Vasilescu, A. [JINR, Dubna (Russian Federation); Biggeri, U.; Borchi, E.; Bruzzi, M. [Univ. of Florence (Italy)]|[INFN, Florence (Italy); Li, Z.; Kraner, H.W. [Brookhaven National Lab., Upton, NY (United States)

1994-02-01T23:59:59.000Z

47

A fourier spectrometer for studying the radiation from Josephson Junctions  

SciTech Connect (OSTI)

The paper describes a Fourier spectrometer designed to study the radiation generated by a Josephson junction in the millimeter and FIR bands with a resolution of {approx}2 GHz in the two-pass mode and {approx}1 GHz in the multipass mode. A feature is that one Josephson junctions operates as both generator and detector at the same time.

Verevkin, A.A.; Il`in, V.A.; Lipatov, A.P. [V.I. Lenin Moscow Pedagogical State Univ., Moscow (Russian Federation)

1995-06-01T23:59:59.000Z

48

Solar radiation management impacts on agriculture in China: A case study in the Geoengineering  

E-Print Network [OSTI]

Solar radiation management impacts on agriculture in China: A case study in the Geoengineering-Earth Science and Technology, Yokohama, Japan Abstract Geoengineering via solar radiation management could affect agricultural productivity due to changes in temperature, precipitation, and solar radiation

Robock, Alan

49

Study on neutron radiation field of carbon ions therapy  

E-Print Network [OSTI]

Carbon ions offer significant advantages for deep-seated local tumors therapy due to their physical and biological properties. Secondary particles, especially neutrons caused by heavy ion reactions should be carefully considered in treatment process and radiation protection. For radiation protection purposes, the FLUKA Code was used in order to evaluate the radiation field at deep tumor therapy room of HIRFL in this paper. The neutron energy spectra, neutron dose and energy deposition of carbon ion and neutron in tissue-like media was studied for bombardment of solid water target by 430MeV/u C ions. It is found that the calculated neutron dose have a good agreement with the experimental date, and the secondary neutron dose may not exceed one in a thousand of the carbon ions dose at Bragg peak area in tissue-like media.

Xu, Jun-Kui; Li, Wu-Yuan; Yan, Wei-Wei; Chen, Xi-Meng; Mao, Wang; Pang, Cheng-Guo

2015-01-01T23:59:59.000Z

50

Radiation damage studies using small-angle neutron scattering  

SciTech Connect (OSTI)

This contribution reviews a number of small-angle neutron scattering (SANS) studies of irradiated metals and steels of relevance to fission and fusion technology. Information obtainable by SANS measurements is recalled with special reference to the determination of the size distribution function of the microstructural inhomogeneities. The selected examples concern studies of the main kinds of radiation defects: voids, precipitates, He-bubbles. Some recent results obtained on structural materials for the first-wall of fusion reactors are also presented.

Albertini, G.; Rustichelli, F. [INFM, Ancona (Italy); Carsughi, F. [INFM, Ancona (Italy). Ist. di Scienze Fisiche; [KFA, Juelich (Germany). Inst. fuer Festkoerperforschung; Coppola, R. [ENEA-Casaccia, Roma (Italy); Stefanon, M. [ENEA, Bologna (Italy)

1996-12-31T23:59:59.000Z

51

Solid low-level radioactive waste radiation stability studies  

E-Print Network [OSTI]

properties and condition; on the other, on the specific features of thermal and radiation influences on it (Spitsyn et al. 1983). For the average composition of the fission products going to wastes repositories, the mean energy of irradiation may vary from... to the container determines, in part, the life of the container. Cormsion studies of containers by solidified wastes has indicated no problem areas in limited measurements to date; however very long-term effects have not been evaluated. The useful life...

Williams, Arnold Andre?

1989-01-01T23:59:59.000Z

52

A new radiometer for earth radiation budget studies  

SciTech Connect (OSTI)

A critical need for the US Global Change Research Program is to provide continuous, well-calibrated radiometric data for radiation balance studies. This paper describes a new, compact, relatively light-weight, adaptable radiometer which will provide both spectrally integrated measurements and data in selected spectral bands. The radiometer design is suitable for use on (small) satellites, aircraft, or Unmanned Aerospace Vehicles (UAVs). Some considerations for the implementation of this radiometer on a small satellite are given. 17 refs.

Weber, P.G.

1992-05-01T23:59:59.000Z

53

CARES: Carbonaceous Aerosol and Radiative Effects Study Science Plan  

SciTech Connect (OSTI)

Carbonaceous aerosol components, which include black carbon (BC), urban primary organic aerosols (POA), biomass burning aerosols, and secondary organic aerosols (SOA) from both urban and biogenic precursors, have been previously shown to play a major role in the direct and indirect radiative forcing of climate. The primary objective of the CARES 2010 intensive field study is to investigate the evolution of carbonaceous aerosols of different types and their effects on optical and cloud formation properties.

Zaveri, RA; Shaw, WJ; Cziczo, DJ

2010-05-27T23:59:59.000Z

54

Development of a combined model of tissue kinetics and radiation response of human bronchiolar epithelium with single cell resolution  

E-Print Network [OSTI]

Lack of accurate data for epidemiological studies of low dose radiation effects necessitates development of dosimetric models allowing prediction of cancer risks for different organs. The objective of this work is to develop a model of the radiation...

Ostrovskaya, Natela Grigoryevna

2006-10-30T23:59:59.000Z

55

Radiation- and Depleted Uranium-Induced Carcinogenesis Studies: Characterization of the Carcinogenic Process and Development of Medical Countermeasures  

E-Print Network [OSTI]

External or internal contamination from radioactive elements during military operations or a terrorist attack is a serious threat to military and civilian populations. External radiation exposure could result from conventional military scenarios including nuclear weapons use and low-dose exposures during radiation accidents or terrorist attacks. Alternatively, internal radiation exposure could result from depleted uranium exposure via DU shrapnel wounds or inhalation. The long-term health effects of these types of radiation exposures are not well known. Furthermore, development of pharmacological countermeasures to low-dose external and internal radiological contamination is essential to the health and safety of both military and civilian populations. The purpose of these studies is to evaluate low-dose radiation or DU-induced carcinogenesis using in vitro and in vivo models, and to test safe and efficacious medical countermeasures. A third goal of these studies is to identify biomarkers of both exposure and disease development. Initially, we used a human cell model (human osteoblast cells, HOS) to evaluate the carcinogenic potential of DU in vitro by assessing morphological transformation, genotoxicity (chromosomal aberrations), mutagenic (HPRT loci), and genomic instability. As a comparison, low-dose cobalt radiation, broad-beam alpha particles, and other military-projectile metals, i.e., tungsten mixtures, are being examined. Published data from

A. C. Miller; D. Beltran; R. Rivas; M. Stewart; R. J. Merlot; P. B. Lison

56

A Study of Radiative Bottomonium Transitions using Converted Photons  

SciTech Connect (OSTI)

The authors use (111 {+-} 1) million {Upsilon}(3S) and (89 {+-} 1) million {Upsilon}(2S) events recorded by the BABAR detector at the PEP-II B-factory at SLAC to perform a study of radiative transitions betwen bottomonium states using photons that have been converted to e{sup +}e{sup -} pairs by the detector material. They observe {Upsilon}(3S) {yields} {gamma}{chi}{sub b0,2}(1P) decay, make precise measurements of the branching fractions for {chi}{sub b1,2}(1P, 2P) {yields} {gamma}{Upsilon}(1S) and {chi}{sub b1,2}(2P) {yields} {gamma}{Upsilon}(2S) decays, and search for radiative decay to the {eta}{sub b}(1S) and {eta}{sub b}(2S) states.

Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; /INFN, Bari /Bari U.; Milanes, D.A.; /INFN, Bari; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

2011-08-15T23:59:59.000Z

57

Study of the Radiation-Hardness of VCSEL and PIN  

E-Print Network [OSTI]

The silicon trackers of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN (Geneva) use optical links for data transmission. An upgrade of the trackers is planned for the Super LHC (SLHC), an upgraded LHC with ten times higher luminosity. We study the radiation-hardness of VCSELs (Vertical-Cavity Surface-Emitting Laser) and GaAs and silicon PINs using 24 GeV/c protons at CERN for possible application in the data transmission upgrade. The optical power of VCSEL arrays decreases significantly after the irradiation but can be partially annealed with high drive currents. The responsivities of the PIN diodes also decrease significantly after irradiation, but can be recovered by operating at higher bias voltage. This provides a simple mechanism to recover from the radiation damage.

Gan, K K; Fernando, W; Kagan, H P; Kass, R D; Lebbai, M R M; Merritt, H; Moore, J R; Nagarkar, A; Rizatdinova, F; Skubic, P L; Smith, D S; Strang, M

2009-01-01T23:59:59.000Z

58

Radiation Damage Study for PHENIX Silicon Stripixel Sensors  

E-Print Network [OSTI]

Silicon stripixel sensors which were developed at BNL will be installed as part of the RHIC-PHENIX silicon vertex tracker (VTX). RHIC II operations provide luminosity up to 2x10^32 /cm2/s so the silicon stripixel sensors will be exposed to a significant amount of radiation. The most problematic radiation effect for VTX is the increase of leakage current, which degrades the signal to noise ratio and may saturate the readout electronics. We studied the radiation damage using the same diodes as CERN-RD48. First, the proportionality between the irradiation fluence and the increase of leakage current of CERN-RD48 was reproduced. Then beam experiments with stripixel sensor were done in which leakage current was found to increase in the same way as that of thereference diode. A stripixel sensor was also irradiated at the PHENIX interaction region (IR) during the 2006 run. We found the same relation between the integrated luminosity and determined fluence from increase of leakage current. The expected fluence is 3-6x10^12 Neq/cm2 (1 MeV neutron equivalent) in RHIC II operations for 10 years. Due to this expected exposure, setting the operating temperature in PHENIX to T< 0 deg. C to suppress leakage current is needed to avoid saturation of preamplifiers.

J. Asai; S. Batsouli; K. Boyle; V. Castillo; V. Cianciolo; D. Fields; C. Haegeman; M. Hoeferkamp; Y. Hosoi; R. Ichimiya; Y. Inoue; M. Kawashima; T. Komatsubara; K. Kurita; Z. Li; D. Lynch; M. Nguyen; T. Murakami; R. Nouicer; H. Ohnishi; R. Pak; K. Sakashita; T. -A. Shibata; K. Suga; A. Taketani; J. Tojo

2007-10-14T23:59:59.000Z

59

Human brain cancer studied by resonance Raman spectroscopy  

E-Print Network [OSTI]

Human brain cancer studied by resonance Raman spectroscopy Yan Zhou Cheng-Hui Liu Yi Sun Yang Pu://biomedicaloptics.spiedigitallibrary.org/ on 11/16/2012 Terms of Use: http://spiedl.org/terms #12;Human brain cancer studied by resonance Raman of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro

Sun, Yi

60

Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments  

SciTech Connect (OSTI)

Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

NONE

1997-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Radiative Effects of Dust Aerosols, Natural Cirrus Clouds and Contrails: Broadband Optical Properties and Sensitivity Studies  

E-Print Network [OSTI]

This dissertation aims to study the broadband optical properties and radiative effects of dust aerosols and ice clouds. It covers three main topics: the uncertainty of dust optical properties and radiative effects from the dust particle shape...

Yi, Bingqi

2013-07-09T23:59:59.000Z

62

Radiation Dose to the Esophagus From Breast Cancer Radiation Therapy, 1943-1996: An International Population-Based Study of 414 Patients  

SciTech Connect (OSTI)

Purpose: To provide dosimetric data for an epidemiologic study on the risk of second primary esophageal cancer among breast cancer survivors, by reconstructing the radiation dose incidentally delivered to the esophagus of 414 women treated with radiation therapy for breast cancer during 1943-1996 in North America and Europe. Methods and Materials: We abstracted the radiation therapy treatment parameters from each patients radiation therapy record. Treatment fields included direct chest wall (37% of patients), medial and lateral tangentials (45%), supraclavicular (SCV, 64%), internal mammary (IM, 44%), SCV and IM together (16%), axillary (52%), and breast/chest wall boosts (7%). The beam types used were {sup 60}Co (45% of fields), orthovoltage (33%), megavoltage photons (11%), and electrons (10%). The population median prescribed dose to the target volume ranged from 21 Gy to 40 Gy. We reconstructed the doses over the length of the esophagus using abstracted patient data, water phantom measurements, and a computational model of the human body. Results: Fields that treated the SCV and/or IM lymph nodes were used for 85% of the patients and delivered the highest doses within 3 regions of the esophagus: cervical (population median 38 Gy), upper thoracic (32 Gy), and middle thoracic (25 Gy). Other fields (direct chest wall, tangential, and axillary) contributed substantially lower doses (approximately 2 Gy). The cervical to middle thoracic esophagus received the highest dose because of its close proximity to the SCV and IM fields and less overlying tissue in that part of the chest. The location of the SCV field border relative to the midline was one of the most important determinants of the dose to the esophagus. Conclusions: Breast cancer patients in this study received relatively high incidental radiation therapy doses to the esophagus when the SCV and/or IM lymph nodes were treated, whereas direct chest wall, tangentials, and axillary fields contributed lower doses.

Lamart, Stephanie, E-mail: stephanie.lamart@nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Simon, Steven L. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Smith, Susan A.; Weathers, Rita E.; Howell, Rebecca M. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Curtis, Rochelle E. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands)] [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Travis, Lois [Rubin Center for Cancer Survivorship and Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States)] [Rubin Center for Cancer Survivorship and Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Kwon, Deukwoo [Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida (United States)] [Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida (United States); Morton, Lindsay M. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-07-15T23:59:59.000Z

63

Roadmap: Human Development and Family Studies -Gerontology -Bachelor of Science  

E-Print Network [OSTI]

Roadmap: Human Development and Family Studies - Gerontology - Bachelor of Science [EH Catalog Year: 2012­2013 Page 1 of 3 | Last Updated: 8-June-12/JS This roadmap is a recommended semester or upper division) 3 See note 2 on page 2 #12;Roadmap: Human Development and Family Studies - Gerontology

Sheridan, Scott

64

ORISE: Worker Health Studies - Radiation Exposure Data Collection  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Resource Book How to Work With Us Contact Us Oak Ridge Institute for Science Education Radiation Exposure Data Collection ORISE manages large, occupation radition exposure...

65

Coastal-inland solar radiation difference study. Final report  

SciTech Connect (OSTI)

The purpose of this study was to quantify the characteristics of solar insolation in the coastal zone and to determine the effect of the sea breeze circulation on the global insolation. In order to satisfy these objectives, a six station sampling network was established in the coastal plain of southeastern North Carolina, where previous evidence has indicated that the sea breeze circulation is almost a daily occurrence from late May through October. Three sites (Sloop Point, Onslow Beach, and Cape Fear Technical Institute (CFTI)) were located near the coast (coastal sites) to assess the insolation at the coast. A site (Clinton) was located in an area seldom affected by the sea breeze (about 100 km from the coast). Two additional sites, Wallace and Ellis Airport, located between the coastal sites and the control site, were to be used to assess the transient impact of the sea breeze upon the insolation. Pyranometers were located at each site to measure the global insolation. Direct normal insolation measured by a pyrheliometer and ultraviolet radiation measured by uv radiometers were observed at the Sloop Point and Clinton sites only. Data were collected during the calendar year 1978. The results of the study indicated that the global insolation had greater variability over the network during the summer season (June, July, and August). During the summer, there was a systematicdiurnal variation of the difference in global insolation between the inland and the coastal sites.

Bach, W.D. Jr.; Vukovich, F.M.

1980-04-01T23:59:59.000Z

66

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  

SciTech Connect (OSTI)

Purpose: Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damage sensor ataxia-telangiectasia mutated (ATM). We explored the regulation of AMPK by ionizing radiation (IR) and its role as a target for radiosensitization of human cancer cells. Methods and Materials: Lung, prostate, and breast cancer cells were treated with IR (2-8 Gy) after incubation with either ATM or AMPK inhibitors or the AMPK activator metformin. Then, cells were subjected to either lysis and immunoblotting, immunofluorescence microscopy, clonogenic survival assays, or cell cycle analysis. Results: IR induced a robust phosphorylation and activation of AMPK in all tumor cells, independent of LKB1. IR activated AMPK first in the nucleus, and this extended later into cytoplasm. The ATM inhibitor KU-55933 blocked IR activation of AMPK. AMPK inhibition with Compound C or anti-AMPK {alpha} subunit small interfering RNA (siRNA) blocked IR induction of the cell cycle regulators p53 and p21{sup waf/cip} as well as the IR-induced G2/M arrest. Compound C caused resistance to IR, increasing the surviving fraction after 2 Gy, but the anti-diabetic drug metformin enhanced IR activation of AMPK and lowered the surviving fraction after 2 Gy further. Conclusions: We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21{sup waf/cip} and regulation of the cell cycle and survival. AMPK appears to (1) participate in an ATM-AMPK-p21{sup waf/cip} pathway, (2) be involved in regulation of the IR-induced G2/M checkpoint, and (3) may be targeted by metformin to enhance IR responses.

Sanli, Toran; Rashid, Ayesha; Liu Caiqiong [Department of Oncology, Juravinski Cancer Center and McMaster University, Hamilton, Ontario (Canada)

2010-09-01T23:59:59.000Z

67

Medieval Studies The School of Humanities  

E-Print Network [OSTI]

and their common traditions,in the period between 500 and 1500 ad.The program combines a broad background, French, or Latin), music, philosophy, or religion. Degree Requirements for BA in Medieval Studies in Medieval Studies MDST 368 Mythologies French Studies MDST 404 Beginnings of Language and Literature

Richards-Kortum, Rebecca

68

Medieval Studies The School of Humanities  

E-Print Network [OSTI]

, in the period between 500 and 1500 ad.The program combines a broad background in various aspects of medieval history, history, literature (Arabic, Chinese, German, Italian, English, French, or Latin), music MDST 320 Directed Readings in Medieval Studies MDST 368 Mythologies French Studies MDST 404 Beginnings

Richards-Kortum, Rebecca

69

Medieval Studies The School of Humanities  

E-Print Network [OSTI]

and their common traditions, in the period between 500 and 1500 ad.The program combines a broad background, French, or Latin), music, philosophy, or religion. Degree Requirements for BA in Medieval Studies MDST 368 Mythologies French Studies MDST 404 Beginnings of Language and Literature of France MDST 410

Richards-Kortum, Rebecca

70

Second Solid Cancers After Radiation Therapy: A Systematic Review of the Epidemiologic Studies of the Radiation Dose-Response Relationship  

SciTech Connect (OSTI)

Rapid innovations in radiation therapy techniques have resulted in an urgent need for risk projection models for second cancer risks from high-dose radiation exposure, because direct observation of the late effects of newer treatments will require patient follow-up for a decade or more. However, the patterns of cancer risk after fractionated high-dose radiation are much less well understood than those after lower-dose exposures (0.1-5 Gy). In particular, there is uncertainty about the shape of the dose-response curve at high doses and about the magnitude of the second cancer risk per unit dose. We reviewed the available evidence from epidemiologic studies of second solid cancers in organs that received high-dose exposure (>5 Gy) from radiation therapy where dose-response curves were estimated from individual organ-specific doses. We included 28 eligible studies with 3434 second cancer patients across 11 second solid cancers. Overall, there was little evidence that the dose-response curve was nonlinear in the direction of a downturn in risk, even at organ doses of ?60 Gy. Thyroid cancer was the only exception, with evidence of a downturn after 20 Gy. Generally the excess relative risk per Gray, taking account of age and sex, was 5 to 10 times lower than the risk from acute exposures of <2 Gy among the Japanese atomic bomb survivors. However, the magnitude of the reduction in risk varied according to the second cancer. The results of our review provide insights into radiation carcinogenesis from fractionated high-dose exposures and are generally consistent with current theoretical models. The results can be used to refine the development of second solid cancer risk projection models for novel radiation therapy techniques.

Berrington de Gonzalez, Amy, E-mail: berringtona@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Gilbert, Ethel; Curtis, Rochelle; Inskip, Peter; Kleinerman, Ruth; Morton, Lindsay; Rajaraman, Preetha; Little, Mark P. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-06-01T23:59:59.000Z

71

Medieval Studies The School of Humanities  

E-Print Network [OSTI]

their differences and their common traditions, in the period between 500 and 1500 AD The program combines a broad.These fields of emphasis include art history,history,medieval literature (English,French,or Latin), music J. R. R. Tolkien MDST 368 Mythologies French Studies MDST 410 The Literary and Historical Image

Richards-Kortum, Rebecca

72

ACCEPTABLE HUMANITIES (HU) COURSES * African American Studies  

E-Print Network [OSTI]

AR 251 Ancient Maya Civilization Art History Any 100-, 200- or 300-level CAS AH course Cinema Studies CAS CI 101 History of Global Cinema 1: Origins through 1950s CAS CI 102 History of Global Cinema 2 in American Literature CAS EN 128 Representing Boston CAS EN 130 Literature and Science CAS EN 141 Literary

73

ACCEPTABLE HUMANITIES (HU) COURSES * African Studies  

E-Print Network [OSTI]

Maya Civilization Art History Any 100-, 200- or 300-level CAS AH course Cinema Studies CAS CI 101 History of Global Cinema 1: Origins through 1950s CAS CI 102 History of Global Cinema 2: 1960s to Present Representing Boston CAS EN 130 Literature and Science CAS EN 141 Literary Types: Fiction CAS EN 142 Literary

74

Center for Environmental Radiation Studies 1 Texas Tech University  

E-Print Network [OSTI]

and international nuclear safety. Critical Success Factors Critical measures of success shall include regarding nuclear research, nuclear safety, biological effects, and homeland security · Training of graduate students and post-doctorates in the areas of molecular genetic responses, radiation dosimetry

Chesser, Ronald Keith

75

Advisory Committee on human radiation experiments. Final report, Supplemental Volume 2. Sources and documentation  

SciTech Connect (OSTI)

This volume and its appendixes supplement the Advisory Committee`s final report by reporting how we went about looking for information concerning human radiation experiments and intentional releases, a description of what we found and where we found it, and a finding aid for the information that we collected. This volume begins with an overview of federal records, including general descriptions of the types of records that have been useful and how the federal government handles these records. This is followed by an agency-by-agency account of the discovery process and descriptions of the records reviewed, together with instructions on how to obtain further information from those agencies. There is also a description of other sources of information that have been important, including institutional records, print resources, and nonprint media and interviews. The third part contains brief accounts of ACHRE`s two major contemporary survey projects (these are described in greater detail in the final report and another supplemental volume) and other research activities. The final section describes how the ACHRE information-nation collections were managed and the records that ACHRE created in the course of its work; this constitutes a general finding aid for the materials deposited with the National Archives. The appendices provide brief references to federal records reviewed, descriptions of the accessions that comprise the ACHRE Research Document Collection, and descriptions of the documents selected for individual treatment. Also included are an account of the documentation available for ACHRE meetings, brief abstracts of the almost 4,000 experiments individually described by ACHRE staff, a full bibliography of secondary sources used, and other information.

NONE

1995-01-01T23:59:59.000Z

76

Appendix G. Radiation Appendix G. Radiation  

E-Print Network [OSTI]

-made sources. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation of radiation and its effects on the environment and biological systems. Radiation comes from natural and humanAppendix G. Radiation #12;#12;Appendix G. Radiation This appendix presents basic facts about

Pennycook, Steve

77

Study of Emission TurbulenceRadiation Interaction in Hypersonic Boundary Layers  

E-Print Network [OSTI]

Study of Emission Turbulence­Radiation Interaction in Hypersonic Boundary Layers L. Duan and M. P of emission turbulence­radiation interaction in hypersonic turbulent boundary layers, representative interaction between turbulence and emission at the hypersonic environment under investigation. An explanation

Martín, Pino

78

STUDIES OF LASER-DRIVEN RADIATIVE BLAST WAVES A.D. EDENS1  

E-Print Network [OSTI]

-driven radiating blast waves. In the first set of experiments the effect of a drive laser's passage throughSTUDIES OF LASER-DRIVEN RADIATIVE BLAST WAVES A.D. EDENS1 , T. DITMIRE1 , J.F. HANSEN2 , M a background gas on the hydrodynamical evolution of blast waves was examined. The laser's passage heated

Ditmire, Todd

79

Effect of microwave radiation on Jayadhar cotton fibers: WAXS studies  

SciTech Connect (OSTI)

Thermal effect in the form of micro wave energy on Jayadhar cotton fiber has been investigated. Microstructural parameters have been estimated using wide angle x-ray scattering (WAXS) data and line profile analysis program developed by us. Physical properties like tensile strength are correlated with X-ray results. We observe that the microwave radiation do affect significantly many parameters and we have suggested a multivariate analysis of these parameters to arrive at a significant result.

Niranjana, A. R., E-mail: arnphysics@gmail.com; Mahesh, S. S., E-mail: arnphysics@gmail.com; Divakara, S., E-mail: arnphysics@gmail.com; Somashekar, R., E-mail: arnphysics@gmail.com [Department of Studies in Physics, University of Mysore, Mysore-570006 (India)

2014-04-24T23:59:59.000Z

80

DOE Zero Energy Ready Home Case Study: Habitat for Humanity South...  

Energy Savers [EERE]

Home Case Study, Manatee County Habitat for Humanity, Ellenton, FL, Affordable DOE Zero Energy Ready Home Case Study: Southeast Volusia Habitat for Humanity, Edgewater, FL...

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease  

SciTech Connect (OSTI)

Purpose: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Methods and Materials: Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Results: Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +- 9.01 vs. 41.94 +- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +- 1303 vs. 1667 +- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +- 1084 vs. 1566 +- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.

Hu Shunying; Chen Yundai [Department of Cardiology, Chinese PLA General Hospital, Beijing (China); Li Libing [Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing (China); Chen Jinlong; Wu Bin [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Zhou, Xiao; Zhi Guang [Department of Cardiology, Chinese PLA General Hospital, Beijing (China); Li Qingfang; Wang Rongliang; Duan Haifeng; Guo Zikuan; Yang Yuefeng; Xiao Fengjun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Wang Hua, E-mail: wanghua@nic.bmi.ac.c [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Wang Lisheng [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China)

2009-12-01T23:59:59.000Z

82

Radiative Closure Studies at the NSA ACRF Site  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298, and 323 RS-PO-0001-001.docW.RadiationFilms.

83

Experimental and theoretical study of red-shifted solitonic resonant radiation in photonic crystal fibers and generation of radiation seeded Raman solitons  

E-Print Network [OSTI]

The red shifted solitonic resonant radiation is a fascinating phase matching phenomenon that occurs when an optical pulse, launched in the normal dispersion regime of photonic crystal fiber, radiates across the zero dispersion wavelength. The formation of such phase-matched radiation is independent of the generation of any optical soliton and mainly governed by the leading edge of input pump which forms a shock front. The radiation is generated at the anomalous dispersion regime and found to be confined both in time and frequency domain. We experimentally investigate the formation of such radiations in photonic crystal fibers with detailed theoretical analysis. Our theoretical predictions corroborate well with experimental results. Further we extend our study for long length fiber and investigate the interplay between red-shifted solitonic resonant radiation and intrapulse Raman scattering (IPRS). It is observed that series of radiation-seeded Raman solitons are generated in anomalous dispersion regime.

Bose, Surajit; Chattopadhyay, Rik; Pal, Mrinmay; Bhadra, Shyamal K

2015-01-01T23:59:59.000Z

84

LET dependence of radiation-induced bystander effects using human prostate tumor cells  

E-Print Network [OSTI]

In the past fifteen years, evidence provided by many independent research groups have indicated higher numbers of cells exhibiting damage than expected based on the number of cells traversed by the radiation. This phenomenon ...

Anzenberg, Vered

2008-01-01T23:59:59.000Z

85

Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, 18F-PBR06,  

E-Print Network [OSTI]

at various time points. Radiation absorbed doses were estimated by the MIRD scheme. Results: Moderate to high and spleen may limit the amount of permissible injected radioactivity. Key Words: MIRD scheme; defluorination

Shen, Jun

86

Prospective Study of Local Control and Late Radiation Toxicity After Intraoperative Radiation Therapy Boost for Early Breast Cancer  

SciTech Connect (OSTI)

Purpose: To report the local recurrence rate and late toxicity of intraoperative radiation therapy (IORT) boost to the tumor bed using the Intrabeam System followed by external-beam whole-breast irradiation (WBI) in women with early-stage breast cancer in a prospective single-institution study. Methods and Materials: Women with breast cancer ?3 cm were recruited between February 2003 and May 2005. After breast-conserving surgery, a single dose of 5 Gy IORT boost was delivered using 50-kV x-rays to a depth of 10 mm from the applicator surface. This was followed by WBI to a total dose of 50 Gy in 25 fractions. Patients were reviewed at regular, predefined intervals. Late toxicities were recorded using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring systems. Results: Fifty-five patients completed both IORT boost and external-beam WBI. Median follow-up was 3.3 years (range, 1.4-4.1 years). There was no reported locoregional recurrence or death. One patient developed distant metastases. Grade 2 and 3 subcutaneous fibrosis was detected in 29 (53%) and 8 patients (15%), respectively. Conclusions: The use of IORT as a tumor bed boost using kV x-rays in breast-conserving therapy was associated with good local control but a clinically significant rate of grade 2 and 3 subcutaneous fibrosis.

Chang, David W., E-mail: David.Chang@petermac.org [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); Marvelde, Luc te [Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); Chua, Boon H. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria (Australia); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria (Australia)

2014-01-01T23:59:59.000Z

87

Policy and Procedures 1 HUMAN DEVELOPMENT AND FAMILY STUDIES  

E-Print Network [OSTI]

Policy and Procedures 1 HUMAN DEVELOPMENT AND FAMILY STUDIES POLICY AND PROCEDURES MANUAL Approved by HDFS Faculty October, 2011 #12;Policy and Procedures 2 Contents Page I. Department Mission. Standing and Ad Hoc Committees 6-9 III. Department Procedures 9 A. General Operating Procedures

Rock, Chris

88

A Study of Longwave Radiation Codes for Climate Studies: Validation with ARM Observations and Tests in General Circulation Models  

SciTech Connect (OSTI)

One specific goal of the Atmospheric Radiation Measurements (ARM) program is to improve the treatment of radiative transfer in General Circulation Models (GCMs) under clear-sky, general overcast and broken cloud conditions. Our project was geared to contribute to this goal by attacking major problems associated with one of the dominant radiation components of the problem --longwave radiation. The primary long-term project objectives were to: (1) develop an optimum longwave radiation model for use in GCMs that has been calibrated with state-of-the-art observations for clear and cloudy conditions, and (2) determine how the longwave radiative forcing with an improved algorithm contributes relatively in a GCM when compared to shortwave radiative forcing, sensible heating, thermal advection and convection. The approach has been to build upon existing models in an iterative, predictive fashion. We focused on comparing calculations from a set of models with operationally observed data for clear, overcast and broken cloud conditions. The differences found through the comparisons and physical insights have been used to develop new models, most of which have been tested with new data. Our initial GCM studies used existing GCMs to study the climate model-radiation sensitivity problem. Although this portion of our initial plans was curtailed midway through the project, we anticipate that the eventual outcome of this approach will provide both a better longwave radiative forcing algorithm and from our better understanding of how longwave radiative forcing influences the model equilibrium climate, how improvements in climate prediction using this algorithm can be achieved.

Robert G. Ellingson

2004-09-28T23:59:59.000Z

89

Studies of laser-driven radiative blast waves  

SciTech Connect (OSTI)

We have performed two sets of experiments looking at laser-driven radiating blast waves. In one set of experiments the effect of a drive laser's passage through a background gas on the hydrodynamical evolution of blast waves was examined. It was found that the laser's passage heats a channel in the gas, creating a region where a portion of the blast wave front had an increased velocity, leading to the formation of a bump-like protrusion on the blast wave. The second set of experiments involved the use of regularly spaced wire arrays to induce perturbations on a blast wave surface. The decay of these perturbations as a function of time was measured for various wave number perturbations and found to be in good agreement with theoretical predictions.

Edwards, M J; Hansen, J; Edens, A; Ditmire, T; Adams, R; Rambo, P; Ruggles, L; Smith, I; Porter, J

2004-04-29T23:59:59.000Z

90

THE NATIONAL CENTER FOR RADIOECOLOGY: A NETWORK OF EXCELLENCE FOR ENVIRONMENTAL AND HUMAN RADIATION RISK REDUCTION  

SciTech Connect (OSTI)

Radioecology in the United States can be traced back to the early 1950s when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a graduate education training program for radioecology. Recently, NCoRE hosted a workshop to identify the immediate needs for science-driven discoveries, tool development and the generation of scientific data to support the legislative decision-making process for remediation strategies, long-term monitoring of radiologically-contaminated sites and protection of human health and the environment. Some of the immediate strategic research needs were identified in the fields of functional genomics for determining low-dose effects, improved low-level dosimetry, and mixed (radiological and chemical) contaminant studies. Longer term strategic research and tool development areas included development of radioecology case study sites, comprehensive decision-making tools, consequence response actions, and optimized scenario based ecosystem modeling. A summary of the NCoRE workshop findings related to waste management needs and priority areas will be presented in this paper.

Jannik, T.

2013-01-09T23:59:59.000Z

91

Studies in feed spoilage: prevention of spoilage in ground corn by gamma radiation  

E-Print Network [OSTI]

of gam- 6 ma radiation. If gamma rays can be used to preserve foods, it seems pos- sible that they may be used also to prevent losses in grains, feed ingred- ients, and mixed feeds. It is anticipated that the dose high enough to destroy insects... not been studied extensively. Investigations on the use of gamma radiation for the preservation of various feed ingredients need to be carried out to determine: (I) the effect of gamma radiation on the growth of molds im feeds irradiated at different...

Webb, Billy Dean

1959-01-01T23:59:59.000Z

92

Framework for Human-Automation Collaboration: Conclusions from Four Studies  

SciTech Connect (OSTI)

The Human Automation Collaboration (HAC) research project is investigating how advanced technologies that are planned for Advanced Small Modular Reactors (AdvSMR) will affect the performance and the reliability of the plant from a human factors and human performance perspective. The HAC research effort investigates the consequences of allocating functions between the operators and automated systems. More specifically, the research team is addressing how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. Oxstrand et al. (2013 - March) describes the efforts conducted by the researchers to identify the research needs for HAC. The research team reviewed the literature on HAC, developed a model of HAC, and identified gaps in the existing knowledge of human-automation collaboration. As described in Oxstrand et al. (2013 June), the team then prioritized the research topics identified based on the specific needs in the context of AdvSMR. The prioritization was based on two sources of input: 1) The preliminary functions and tasks, and 2) The model of HAC. As a result, three analytical studies were planned and conduced; 1) Models of Teamwork, 2) Standardized HAC Performance Measurement Battery, and 3) Initiators and Triggering Conditions for Adaptive Automation. Additionally, one field study was also conducted at Idaho Falls Power.

Johanna Oxstrand; Katya L. Le Blanc; John O'Hara; Jeffrey C. Joe; April M. Whaley; Heather Medema

2013-11-01T23:59:59.000Z

93

Effects of PGF{sub 2{alpha}} on human melanocytes and regulation of the FP receptor by ultraviolet radiation  

SciTech Connect (OSTI)

Prostaglandins are potent lipid hormones that activate multiple signaling pathways resulting in regulation of cellular growth, differentiation, and apoptosis. In the skin, prostaglandins are rapidly released by keratinocytes following ultraviolet radiation and are chronically present in inflammatory skin lesions. We have shown previously that melanocytes, which provide photoprotection to keratinocytes through the production of melanin, express several receptors for prostaglandins, including the PGE{sub 2} receptors EP{sub 1} and EP{sub 3} and the PGF{sub 2{alpha}} receptor FP, and that PGF{sub 2{alpha}} stimulates melanocyte dendricity. We now show that PGF{sub 2{alpha}} stimulates the activity and expression of tyrosinase, the rate-limiting enzyme in melanin synthesis. Analysis of FP receptor regulation showed that the FP receptor is regulated by ultraviolet radiation in melanocytes in vitro and in human skin in vivo. We also show that ultraviolet irradiation stimulates production of PGF{sub 2{alpha}} by melanocytes. These results show that PGF{sub 2{alpha}} binding to the FP receptor activates signals that stimulate a differentiated phenotype (dendricity and pigmentation) in melanocytes. The regulation of the FP receptor and the stimulation of production of PGF{sub 2{alpha}} in melanocytes in response to ultraviolet radiation suggest that PGF{sub 2{alpha}} could act as an autocrine factor for melanocyte differentiation.

Scott, Glynis [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)]. E-mail: Glynis_Scott@urmc.rochester.edu; Jacobs, Stacey [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Leopardi, Sonya [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States); Anthony, Frank A. [Schering-Plough HealthCare Products Inc., Memphis TN (United States); Learn, Doug [Charles River DDS, Argus Division, Horsham, PA (United States); Malaviya, Rama [University of Medicine and Dentistry, RWJMS, New Brunswick, NJ (United States); Pentland, Alice [Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642 (United States)

2005-04-01T23:59:59.000Z

94

Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies  

SciTech Connect (OSTI)

Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this study CBA mice with or without T6 chromosome marker were used. Under this experimental condition, the majority of alveolar macrophages in mitosis are of host origin even after 45 weeks. These data suggest that alveolar macrophages are a self-renewing population under normal steady-state conditions.

Tarling, J.D.; Lin, H.S.; Hsu, S.

1987-11-01T23:59:59.000Z

95

JLab, College of W&M researchers study radiation blockers...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

studies of mice. Bob Welsh, a JLabCWM jointly appointed professor, is one researcher working on the project. The research demonstrates that scientists can learn about how the...

96

SR-2508 plus buthionine sulfoximine or SR-2508 alone: effects on the radiation response and the glutathione content of a human tumor xenograft  

SciTech Connect (OSTI)

This study determined the radiosensitivity of the human tumor xenograft HT29 and its glutathione (GSH) and cysteine (CYS) contents after treatment with both buthionine sulfoximine (BSO) and SR-2508 or SR-2508 alone. Tumor radiosensitivity was assessed by the in vitro colony assay and thiol content was measured by high-performance liquid chromatography. The radiosensitizing effect of SR-2508 is dose dependent and increases when higher doses of radiation are given. SR-2508 given alone does not modify GSH and CYS content; however, when given with BSO, the GSH level is significantly reduced, yet radiosensitivity of the HT29 tumor is only slightly increased. These results have been compared to our previously observed results of HT29 treatment with misonidazole (MISO), BSO, or MISO + BSO.

Lespinasse, F.; Biscay, P.; Malaise, E.P.; Guichard, M.

1987-04-01T23:59:59.000Z

97

Radiation Damage Study in Natural Zircon Using Neutrons Irradiation  

SciTech Connect (OSTI)

Changes of atomic displacements in crystalline structure of natural zircon (ZrSiO{sub 4}) can be studied by using neutron irradiation on the surface of zircon and compared the data from XRD measurements before and after irradiation. The results of neutron irradiation on natural zircon using Pneumatic Transfer System (PTS) at PUSPATI TRIGA Research Reactor in the Malaysian Nuclear Agency are discussed in this work. The reactor produces maximum thermal power output of 1 MWatt and the neutron flux of up to 1x10{sup 13} ncm{sup -2}s{sup -1}. From serial decay processes of uranium and thorium radionuclides in zircon crystalline structure, the emission of alpha particles can produce damage in terms of atomic displacements in zircon. Hence, zircon has been extensively studied as a possible candidate for immobilization of fission products and actinides.

Lwin, Maung Tin Moe; Amin, Yusoff Mohd.; Kassim, Hasan Abu [Department of Physics, University of Malaya, 50603 Kuala Lumpur (Malaysia); Mohamed, Abdul Aziz [Materials Technology Group, Industrial Technology Division, Malaysian Nuclear Agency Bangi, 43000 Kajang, Selangor Darul Ehsan (Malaysia); Karim, Julia Abdul [Reactor Physics Section, Nuclear Power Division, Malaysian Nuclear Agency Bangi, 43000 Kajang, Selangor Darul Ehsan (Malaysia)

2011-03-30T23:59:59.000Z

98

CARES: Carbonaceous Aerosol and Radiative Effects Study Operations Plan  

SciTech Connect (OSTI)

The CARES field campaign is motivated by the scientific issues described in the CARES Science Plan. The primary objectives of this field campaign are to investigate the evolution and aging of carbonaceous aerosols and their climate-affecting properties in the urban plume of Sacramento, California, a mid-size, mid-latitude city that is located upwind of a biogenic volatile organic compound (VOC) emission region. Our basic observational strategy is to make comprehensive gas, aerosol, and meteorological measurements upwind, within, and downwind of the urban area with the DOE G-1 aircraft and at strategically located ground sites so as to study the evolution of urban aerosols as they age and mix with biogenic SOA precursors. The NASA B-200 aircraft, equipped with the High Spectral Resolution Lidar (HSRL), digital camera, and the Research Scanning Polarimeter (RSP), will be flown in coordination with the G-1 to characterize the vertical and horizontal distribution of aerosols and aerosol optical properties, and to provide the vertical context for the G-1 and ground in situ measurements.

Zaveri, RA; Shaw, WJ; Cziczo, DJ

2010-07-12T23:59:59.000Z

99

Radiation Damage Studies of Materials and Electronic Devices Using Hadrons  

SciTech Connect (OSTI)

We have irradiated NdFeB permanent magnet samples from different manufacturers and with differing values of coercivity and remanence using stepped doses of 1 MeV equivalent neutrons up to a fluence of 0:64 #2; 1015n=cm2 to evaluate effects on magnetization and B field distributions. The samples with high coercivity, irradiated in open circuit configurations, showed no or minimal effects when compared with unirradiated samples, whereas the lower coercivity magnets suffered significant losses of magnetization and changes in the shapes of their field patterns. One such magnet underwent a fractional magnetization loss of 13.1% after a fluence of 0:59 #2; 1015 n=cm2. This demagnetization was not uniform. With increasing fluence, B field scans along the centerlines of the pole faces revealed that the normal component of B decreased more near the midpoint of the scan than near the ends. In addition, a fit to the curve of overall magnetization loss with fluence showed a significant deviation from linearity. The results are discussed in light of other measurements and theory. The high coercivity materials appear suitable for use in accelerator applications subject to irradiation by fast neutrons such as dipoles where the internal demagnetizing field is comparable to or less than that of the open circuit samples tested in this study.

Pellett, David; Baldwin, Andrew; Gallagher, Garratt; Olson, David; Styczinski, Marshall

2014-05-14T23:59:59.000Z

100

Roadmap: Technical and Applied Studies NonprofitHuman Services Bachelor of Technical and Applied Studies  

E-Print Network [OSTI]

Roadmap: Technical and Applied Studies ­ Nonprofit­Human Services ­ Bachelor of Technical-Aug-12/TET This roadmap is a recommended semester-by-semester plan of study for this major. However / SOC 32570 COMM 35864, COMT 36318 or Visit www.kent.edu/catalog/elr 2.000 2.000 #12;Roadmap: Technical

Sheridan, Scott

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Theoretical study of gas heated in a porous material subjected to a concentrated solar radiation (*)  

E-Print Network [OSTI]

W solar furnace of Solar Energy Laboratory in Odeillo (France). Revue Phys. Appl. 15 (1980) 423-426 MARS423 Theoretical study of gas heated in a porous material subjected to a concentrated solar exposed to the solar radiation. These quantities may be expressed in any set consistent units. 1

Paris-Sud XI, Université de

102

Carbonaceous Aerosols and Radiative Effects Study (CARES), g1-aircraft, sedlacek sp2  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The primary objective of the Carbonaceous Aerosol and Radiative Effects Study (CARES) in 2010 was to investigate the evolution of carbonaceous aerosols of different types and their optical and hygroscopic properties in central California, with a focus on the Sacramento urban plume.

Sedlacek, Art

103

Computational study of atmospheric transfer radiation on an equatorial tropical desert (La Tatacoa, Colombia)  

E-Print Network [OSTI]

Radiative transfer models explain and predict interaction between solar radiation and the different elements present in the atmosphere, which are responsible for energy attenuation. In Colombia there have been neither measurements nor studies of atmospheric components such as gases and aerosols that can cause turbidity and pollution. Therefore satellite images cannot be corrected radiometrically in a proper way. When a suitable atmospheric correction is carried out, loss of information is avoided, which may be useful for discriminating image land cover. In this work a computational model was used to find radiative atmospheric attenuation (300 1000nm wavelength region) on an equatorial tropical desert (La Tatacoa, Colombia) in order to conduct an adequate atmospheric correction.

Delgado-Correal, Camilo; Castao, Gabriel

2012-01-01T23:59:59.000Z

104

An Assessment of the Current US Radiation Oncology Workforce: Methodology and Global Results of the American Society for Radiation Oncology 2012 Workforce Study  

SciTech Connect (OSTI)

Purpose: To determine the characteristics, needs, and concerns of the current radiation oncology workforce, evaluate best practices and opportunities for improving quality and safety, and assess what we can predict about the future workforce. Methods and Materials: An online survey was distributed to 35,204 respondents from all segments of the radiation oncology workforce, including radiation oncologists, residents, medical dosimetrists, radiation therapists, medical physicists, nurse practitioners, nurses, physician assistants, and practice managers/administrators. The survey was disseminated by the American Society for Radiation Oncology (ASTRO) together with specialty societies representing other workforce segments. An overview of the methods and global results is presented in this paper. Results: A total of 6765 completed surveys were received, a response rate of 19%, and the final analysis included 5257 respondents. Three-quarters of the radiation oncologists, residents, and physicists who responded were male, in contrast to the other segments in which two-thirds or more were female. The majority of respondents (58%) indicated they were hospital-based, whereas 40% practiced in a free-standing/satellite clinic and 2% in another setting. Among the practices represented in the survey, 21.5% were academic, 25.2% were hospital, and 53.3% were private. A perceived oversupply of professionals relative to demand was reported by the physicist, dosimetrist, and radiation therapist segments. An undersupply was perceived by physician's assistants, nurse practitioners, and nurses. The supply of radiation oncologists and residents was considered balanced. Conclusions: This survey was unique as it attempted to comprehensively assess the radiation oncology workforce by directly surveying each segment. The results suggest there is potential to improve the diversity of the workforce and optimize the supply of the workforce segments. The survey also provides a benchmark for future studies, as many changes in the healthcare field exert pressure on the workforce.

Vichare, Anushree; Washington, Raynard; Patton, Caroline; Arnone, Anna [ASTRO, Fairfax, Virginia (United States); Olsen, Christine [Massachusetts General Hospital, Boston, Massachusetts, (United States); Fung, Claire Y. [Commonwealth Newburyport Cancer Center, Newburyport, Massachusetts (United States); Hopkins, Shane [William R. Bliss Cancer Center, Ames, Iowa (United States); Pohar, Surjeet, E-mail: spohar@netzero.net [Indiana University Health Cancer Center East, Indiana University, Indianapolis, Indiana (United States)

2013-12-01T23:59:59.000Z

105

A Population-Based Study of the Fractionation of Postlumpectomy Breast Radiation Therapy  

SciTech Connect (OSTI)

Purpose: The optimal fractionation schedule of post lumpectomy radiation therapy remains controversial. The objective of this study was to describe the fractionation of post-lumpectomy radiation therapy (RT) in Ontario, before and after the seminal Ontario Clinical Oncology Group (OCOG) trial, which showed the equivalence of 16- and 25-fraction schedules. Methods and Materials: This was a retrospective cohort study conducted by linking electronic treatment records to a population-based cancer registry. The study population included all patients who underwent lumpectomy for invasive breast cancer in Ontario, Canada, between 1984 and 2008. Results: Over the study period, 41,747 breast cancer patients received post lumpectomy radiation therapy to the breast only. Both 16- and 25-fraction schedules were commonly used throughout the study period. In the early 1980s, shorter fractionation schedules were used in >80% of cases. Between 1985 and 1995, the proportion of patients treated with shorter fractionation decreased to 48%. After completion of the OCOG trial, shorter fractionation schemes were once again widely adopted across Ontario, and are currently used in about 71% of cases; however, large intercenter variations in fractionation persisted. Conclusions: The use of shorter schedules of post lumpectomy RT in Ontario increased after completion of the OCOG trial, but the trial had a less normative effect on practice than expected.

Ashworth, Allison [Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario (Canada) [Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario (Canada); Cancer Center of Southeastern Ontario, Kingston, Ontario (Canada); Kong, Weidong [Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario (Canada)] [Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario (Canada); Whelan, Timothy [Juravinski Cancer Center, Hamilton, Ontario (Canada)] [Juravinski Cancer Center, Hamilton, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Ontario (Canada)

2013-05-01T23:59:59.000Z

106

Study of runaway electrons using dosimetry of hard x-ray radiations in Damavand tokamak  

SciTech Connect (OSTI)

In this work several studies have been conducted on hard x-ray emissions of Damavand tokamak based on radiation dosimetry using the Thermoluminescence method. The goal was to understand interactions of runaway electrons with plasma particles, vessel wall, and plasma facing components. Total of 354 GR-200 (LiF:Mg,Cu,P) thermoluminescence dosimeter (TLD) crystals have been placed on 118 points three TLDs per point to map hard x-ray radiation doses on the exterior of the vacuum vessel. Results show two distinctive levels of x-ray radiations doses on the exterior of the vessel. The low-dose area on which measured dose is about 0.5 mSv/shot. In the low-dose area there is no particular component inside the vessel. On the contrary, on high-dose area of the vessel, x-ray radiations dose exceeds 30 mSv/shot. The high-dose area coincides with the position of limiters, magnetic probe ducts, and vacuum vessel intersections. Among the high-dose areas, the highest level of dose is measured in the position of the limiter, which could be due to its direct contact with the plasma column and with runaway electrons. Direct collisions of runaway electrons with the vessel wall and plasma facing components make a major contribution for production of hard x-ray photons in Damavand tokamak.

Rasouli, C.; Pourshahab, B.; Rasouli, H. [Plasma Physics and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute, AEOI, PO Box 14155-1339, Tehran (Iran, Islamic Republic of)] [Plasma Physics and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute, AEOI, PO Box 14155-1339, Tehran (Iran, Islamic Republic of); Hosseini Pooya, S. M.; Orouji, T. [Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, PO Box 14155-1339, Tehran (Iran, Islamic Republic of)] [Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, PO Box 14155-1339, Tehran (Iran, Islamic Republic of)

2014-05-15T23:59:59.000Z

107

Radium in humans: A review of U.S. studies  

SciTech Connect (OSTI)

This document was originally conceived as a compilation of activities at Argonne National Laboratory that were directed toward the study of radium in humans. However, it soon became obvious that this was a very limited approach, because such a compilation would include no background on the widespread uses of radium in industry and in the medical profession, nor would it address the early history of the discovery of the hazards of radium. Such an approach would also ignore contributions to the study of radium effects made at other laboratories. This document now addresses these topics, in order to give an overall picture of what might be called the radium era, that period from the early part of this century, when radium was rapidly exploited as a tool and a medication, to the present time, when radium is not generally used and the study of its effects has been terminated. The appendix to this review lists all of the measured radium cases, a total of 2,403 individuals whose records were in the files at the end of 1990. For each case the route of exposure, the dates of exposure, the years of birth and death, the measured body content, the calculated intake and dose, and the cause of death have been listed. 165 refs.

Rowland, R.E.

1994-09-01T23:59:59.000Z

108

Modeling aspects of human memory for scientific study.  

SciTech Connect (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

109

Implications of Intercellular Signaling for Radiation Therapy: A Theoretical Dose-Planning Study  

SciTech Connect (OSTI)

Purpose: Recent in vitro results have shown significant contributions to cell killing from signaling effects at doses that are typically used in radiation therapy. This study investigates whether these in vitro observations can be reconciled with in vivo knowledge and how signaling may have an impact on future developments in radiation therapy. Methods and Materials: Prostate cancer treatment plans were generated for a series of 10 patients using 3-dimensional conformal therapy, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy techniques. These plans were evaluated using mathematical models of survival following modulated radiation exposures that were developed from in vitro observations and incorporate the effects of intercellular signaling. The impact on dosevolume histograms and mean doses were evaluated by converting these survival levels into signaling-adjusted doses for comparison. Results: Inclusion of intercellular communication leads to significant differences between the signalling-adjusted and physical doses across a large volume. Organs in low-dose regions near target volumes see the largest increases, with mean signaling-adjusted bladder doses increasing from 23 to 33 Gy in IMRT plans. By contrast, in high-dose regions, there is a small decrease in signaling-adjusted dose due to reduced contributions from neighboring cells, with planning target volume mean doses falling from 74 to 71 Gy in IMRT. Overall, however, the dose distributions remain broadly similar, and comparisons between the treatment modalities are largely unchanged whether physical or signaling-adjusted dose is compared. Conclusions: Although incorporating cellular signaling significantly affects cell killing in low-dose regions and suggests a different interpretation for many phenomena, their effect in high-dose regions for typical planning techniques is comparatively small. This indicates that the significant signaling effects observed in vitro are not contradicted by comparison with clinical observations. Future investigations are needed to validate these effects in vivo and to quantify their ranges and potential impact on more advanced radiation therapy techniques.

McMahon, Stephen J., E-mail: stephen.mcmahon@qub.ac.uk [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); McGarry, Conor K. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Butterworth, Karl T. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); O'Sullivan, Joe M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Clinical Oncology, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Hounsell, Alan R. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)

2013-12-01T23:59:59.000Z

110

Paul Sellin, Centre for Nuclear and Radiation Physics IBIC studies of charge transport in single-crystal  

E-Print Network [OSTI]

Trapping in polycrystalline CVD diamond radiation detectors Diamond radiation detectors require large properties. Polycrystalline CVD diamond devices have been studied for many years: grain boundaries act by : Room temperature de-trapping is observed in polycrystalline diamond, with ~100 ns 10 s. Trapping

Sellin, Paul

111

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect (OSTI)

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

112

Graduate Studies in Industrial and Systems Engineering Human Factors/Ergonomics  

E-Print Network [OSTI]

1 Graduate Studies in Industrial and Systems Engineering Human Factors/Ergonomics 2013-2014 Introduction Human Factors Engineering, also known as Ergonomics, can be briefly defined as the science and skills. At OSU, Human Factors/Ergonomics (HF/E) is composed of two broad areas: Cognitive Engineering

113

Theoretical study of radiative electron attachment to CN, C2H, and C4H radicals  

E-Print Network [OSTI]

A first-principle theoretical approach to study the process of radiative electron attachment is developed and applied to the negative molecular ions CN$^-$, C$_4$H$^-$, and C$_2$H$^-$. Among these anions, the first two have already been observed in the interstellar space. Cross sections and rate coefficients for formation of these ions by radiative electron attachment to the corresponding neutral radicals are calculated. For completeness of the theoretical approach, two pathways for the process have been considered: (i) A direct pathway, in which the electron in collision with the molecule spontaneously emits a photon and forms a negative ion in one of the lowest vibrational levels, and (ii) an indirect, or two-step pathway, in which the electron is initially captured through non-Born-Oppenheimer coupling into a vibrationally resonant excited state of the anion, which then stabilizes by radiative decay. We develop a general model to describe the second pathway and show that its contribution to the formation o...

Douguet, Nicolas; Raoult, Maurice; Dulieu, Olivier; Orel, Ann E; Kokoouline, Viatcheslav

2015-01-01T23:59:59.000Z

114

Structural studies of the human polymeric immunoglobulin receptor  

E-Print Network [OSTI]

The human polymeric immunoglobulin receptor, pIgR, is a glycosylated type I transmembrane protein expressed on the basolateral surface of secretory epithelial cells. pIgR plays a key role in mucosal immunity and, together ...

Hamburger, Agnes Eva, 1976-

2005-01-01T23:59:59.000Z

115

A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer  

SciTech Connect (OSTI)

Purpose: Although complementary and alternative medicine (CAM) utilization in breast cancer patients is reported to be high, there are few data on CAM practices in breast patients specifically during radiation. This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation. Materials/Methods: A validated CAM instrument with a self-skin assessment was administered to 360 Stage 0-III breast cancer patients from 5 centers during the last week of radiation. All data were analyzed to detect significant differences between users/nonusers. Results: CAM usage was reported in 54% of the study cohort (n=194/360). Of CAM users, 71% reported activity-based CAM (eg, Reiki, meditation), 26% topical CAM, and 45% oral CAM. Only 16% received advice/counseling from naturopathic/homeopathic/medical professionals before initiating CAM. CAM use significantly correlated with higher education level (P<.001), inversely correlated with concomitant hormone/radiation therapy use (P=.010), with a trend toward greater use in younger patients (P=.066). On multivariate analysis, level of education (OR: 6.821, 95% CI: 2.307-20.168, P<.001) and hormones/radiation therapy (OR: 0.573, 95% CI: 0.347-0.949, P=.031) independently predicted for CAM use. Significantly lower skin toxicity scores were reported in CAM users vs nonusers, respectively (mild: 34% vs 25%, severe: 17% vs 29%, P=.017). Conclusion: This is the first prospective study to assess CAM practices in breast patients during radiation, with definition of these practices as the first step for future investigation of CAM/radiation interactions. These results should alert radiation oncologists that a large percentage of breast cancer patients use CAM during radiation without disclosure or consideration for potential interactions, and should encourage increased awareness, communication, and documentation of CAM practices in patients undergoing radiation treatment for breast cancer.

Moran, Meena S., E-mail: meena.moran@yale.edu [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Ma Shuangge [Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut (United States)] [Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut (United States); Jagsi, Reshma [University of Michigan, Department of Radiation Oncology, Ann Arbor, MI (United States)] [University of Michigan, Department of Radiation Oncology, Ann Arbor, MI (United States); Yang, Tzu-I Jonathan [Yale University School of Medicine, New Haven, Connecticut (United States)] [Yale University School of Medicine, New Haven, Connecticut (United States); Higgins, Susan A. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Shoreline Medical Center, Guilford, Connecticut (United States); Weidhaas, Joanne B. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Wilson, Lynn D. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Lloyd, Shane [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Peschel, Richard [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Gaudreau, Bryant [Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States)] [Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Rockwell, Sara [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)

2013-01-01T23:59:59.000Z

116

A parametric study of shock jump chemistry, electron temperature, and radiative heat transfer models in hypersonic flows  

E-Print Network [OSTI]

A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN GREENDYKE Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1988 Major Subject: Aerospace Engineering A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN...

Greendyke, Robert Brian

2012-06-07T23:59:59.000Z

117

A study of the effects of radiation on the morphology, cytology and fertility of common dallisgrass  

E-Print Network [OSTI]

studies of the cytological effects of neutrons and x-rays. Genetics 28:398-4i8. 4943. 8. Holt, E. C. Dallisgrass. Texas Agr. Ex. Sta. Bul. 829. f956. 9. Hayman, D. L. Cytological evidence for apomixis in Austral- ian Pas alum dilatatum. J. Austr. Inst.... At Agriculturae Scandinavica IV:3, 585-593. 1954. Knight, W. E. The mfluence of photoperiod and temperature on growth, flowering and seed production of dallisgrass, Pas alum dilatatum. Agron. J. 47:555-559. 1955. Konzak, C. E. Genetic effects of radiation...

Hoff, Bert John

1963-01-01T23:59:59.000Z

118

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

SciTech Connect (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

119

Appendix F. Radiation Appendix F. Radiation F-3  

E-Print Network [OSTI]

from natural and human-made sources. People are exposed to naturally occurring radiation constantlyAppendix F. Radiation #12;#12;Appendix F. Radiation F-3 Appendix F. Radiation This appendix presents basic facts about radiation. The information is intended to be a basis for understanding

Pennycook, Steve

120

Appendix F: Radiation Appendix F: Radiation F-3  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix F: Radiation #12;#12;Appendix F: Radiation F-3 P P P E E E N NN HYDROGEN ATOM DEUTERIUM

Pennycook, Steve

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Appendix F: Radiation Appendix F: Radiation F-3  

E-Print Network [OSTI]

to naturally occurring radiation constantly. For example, cosmic radiation; radon in air; potassium in food on the environment and biological systems. Radiation comes from natural and human-made sources. People are exposedAppendix F: Radiation #12;#12;Appendix F: Radiation F-3 Fig. F.1. The hydrogen atom and its

Pennycook, Steve

122

Appendix G. Radiation Appendix G. Radiation G-3  

E-Print Network [OSTI]

from natural and human-made sources. People are exposed to naturally occurring radiation constantlyAppendix G. Radiation #12;#12;Appendix G. Radiation G-3 Appendix G. Radiation This appendix presents basic facts about radiation. The information is intended to be a basis for un- derstanding

Pennycook, Steve

123

Appendix F. Radiation Appendix F. Radiation F-3  

E-Print Network [OSTI]

from natural and human-made sources. People are exposed to naturally occurring radiation constantlyAppendix F. Radiation #12;#12;Appendix F. Radiation F-3 Appendix F. Radiation This appendix presents basic facts about radiation. The information is intended to be a basis for un- derstanding

Pennycook, Steve

124

SUGGESTED THREE-YEAR GRADUATION PLAN Human Development and Family Studies Case Management  

E-Print Network [OSTI]

Development 3 See note 1 on page 2 HDFS 25512 Management of Family Resources 3 HDFS 34031 Cultural DiversitySUGGESTED THREE-YEAR GRADUATION PLAN Human Development and Family Studies ­Case Management THREE-YEAR GRADUATION PLAN Human Development and Family Studies ­Case Management for Individuals

Sheridan, Scott

125

Low dose radiation hypersensitivity and clustered DNA damages in human fibroblasts exposed to low dose and dose rate protons or 137CS y-rays  

SciTech Connect (OSTI)

Effective radioprotection for human space travelers hinges upon understanding the individual properties of charged particles. A significant fraction of particle radiation astronauts will encounter in space exploratory missions will come from high energy protons in galactic cosmic radiation (GCR) and/or possible exposures to lower energy proton flux from solar particle events (SPEs). These potential exposures present major concerns for NASA and others, in planning and executing long term space exploratory missions. We recently reported cell survival and transformation (acquisition of anchorage-independent growth in soft agar) frequencies in apparently normal NFF-28 primary human fibroblasts exposed to 0-30 cGy of 50MeV, 100MeV (SPE-like), or 1000 MeV (GCR-like) monoenergetic protons. These were modeled after 1989 SPE energies at an SPE-like low dose-rate (LDR) of 1.65 cGy/min or high dose rate (HDR) of 33.3 cGy/min delivered at the NASA Space Radiation Laboratory (NSRL) at BNL.

Bennett P. V.; Bennett, P.V.; Keszenman, D.J.; Johnson, A.M.; Sutherland, B.M.; Wilson, P.F.

2013-05-14T23:59:59.000Z

126

Spreader-Bar Radiation Detection System Enhancements: A Modeling and Simulation Study  

SciTech Connect (OSTI)

This report provides the modeling and simulation results of the investigation of enhanced spreader bar radiation detection systems.

Ely, James H.; Ashbaker, Eric D.; Batdorf, Michael T.; Baciak, James E.; Hensley, Walter K.; Jarman, Kenneth D.; Robinson, Sean M.; Sandness, Gerald A.; Schweppe, John E.

2012-11-13T23:59:59.000Z

127

Essays using military-induced variation to study social interactions, human capital development, and labor markets  

E-Print Network [OSTI]

This dissertation consists of four empirical studies, each using military-induced variation to examine various aspects of human capital production and the U.S. labor market. The first two chapters study the effects of ...

Lyle, David S. (David Stephen), 1971-

2003-01-01T23:59:59.000Z

128

Ultrafast time dynamics studies of periodic lattices with free electron laser radiation  

SciTech Connect (OSTI)

It has been proposed that radiation from free electron laser (FEL) at Hamburg (FLASH) can be used for ultrafast time-resolved x-ray diffraction experiments based on the near-infrared (NIR) pump/FEL probe scheme. Here, investigation probing the ultrafast structural dynamics of periodic nano-crystalline organic matter (silver behenate) with such a scheme is reported. Excitation with a femtosecond NIR laser leads to an ultrafast lattice modification which time evolution has been studied through the scattering of vacuum ultraviolet FEL pulses. The found effect last for 6 ps and underpins the possibility for studying nanoperiodic dynamics down to the FEL source time resolution. Furthermore, the possibility of extending the use of silver behenate (AgBh) as a wavelength and temporal calibration tool for experiments with soft x-ray/FEL sources is suggested.

Quevedo, W.; Busse, G.; Hallmann, J.; More, R.; Petri, M.; Rajkovic, I. [Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen (Germany); Krasniqi, F.; Rudenko, A. [Max Planck Advanced Study Group at CFEL, Notkestrasse 85, 22607 Hamburg (Germany); Tschentscher, T. [European XFEL GmbH, Albert-Einstein-Ring 19, 22671 Hamburg (Germany); Stojanovic, N.; Duesterer, S.; Treusch, R.; Tolkiehn, M. [HASYLAB at DESY, Notkestrasse 85, 22607 Hamburg (Germany); Techert, S. [Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen (Germany); Max Planck Advanced Study Group at CFEL, Notkestrasse 85, 22607 Hamburg (Germany)

2012-11-01T23:59:59.000Z

129

A study to determine statistically and empirically the influence of solar radiation on physiological responses of dairy cattle  

E-Print Network [OSTI]

as to st@Is aad osutea4 bgs ( 1957 IHTRQDUCTIOH REVIEU Qy THE LITERATURE General Observations on Clinstic Causes of Cattle Atnospheric Tenperature and Hnnid1ty Solar Radiation Analysis of the Data Analysis of Variance of Body Teaperature Analysis... ~ vtdenee and no ?xtensive research, tho offsets of solar radiation have been assnned to bs of little inportanoe. This study, a pzo]oot of the Southern Regional Dairy Researsh pro- gras, was designed to dotoznine the relative inportnnoo of solar...

Williams, James Stanley

1957-01-01T23:59:59.000Z

130

Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies  

SciTech Connect (OSTI)

There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

none,

2013-06-06T23:59:59.000Z

131

Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study  

SciTech Connect (OSTI)

Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and grey matter (GM) regions of the rat brain were investigated at molecular level. Sprague-Dawley rats, which were administered amifostine or not, were whole-body irradiated at a single dose of 800 cGy, decapitated after 24 h and the brain tissues of these rats were analyzed using Fourier transform infrared microspectroscopy (FTIRM). The results revealed that the total lipid content and CH{sub 2} groups of lipids decreased significantly and the carbonyl esters, olefinic=CH and CH{sub 3} groups of lipids increased significantly in the WM and GM after exposure to ionizing radiation, which could be interpreted as a result of lipid peroxidation. These changes were more prominent in the WM of the brain. The administration of amifostine before ionizing radiation inhibited the radiation-induced lipid peroxidation in the brain. In addition, this study indicated that FTIRM provides a novel approach for monitoring ionizing radiation induced-lipid peroxidation and obtaining different molecular ratio images can be used as biomarkers to detect lipid peroxidation in biological systems.

Cakmak G.; Miller L.; Zorlu, F.; Severcan, F.

2012-03-03T23:59:59.000Z

132

Performance studies of the ATLAS transition radiation tracker barrel using SR1 cosmics data  

E-Print Network [OSTI]

The ATLAS experiment at the Large Hadron Collider (LHC) is designed to measure Nature at the energy scale often associated with electroweak symmetry breaking. When it comes online in 2008, the LHC and ATLAS will work to discover, among other things, the Higgs boson and any other signatures for physics beyond the Standard Model. As part of the ATLAS Inner Detector, the Transition Radiation Tracker will be an important part of ATLASs ability to make precise measurements of particle properties. This paper summarizes work done to study and categorize the performance of the TRT, using a combination of cosmic ray test data from the SR1 facility and Monte Carlo. In general, it was found that the TRT is working well, with module-level eciencies around 90 % and module-level noise just above 2 %. Reasonably good agreement was observed with Monte Carlo, though there are some apparently pathological dierences between the two that deserve further attention.

Wall, R

133

Study of the Exclusive Initial-State-Radiation Production of the DDbar System  

E-Print Network [OSTI]

A search for charmonium and other new states is performed in a study of exclusive initial-state-radiation production of D Dbar events from electron-positron annihilations at a center-of-mass energy of 10.58 GeV. The data sample corresponds to an integrated luminosity of 384 fb-1 and was recorded by the BABAR experiment at the PEP-II storage ring. The D Dbar mass spectrum shows clear evidence of the psi(3770) plus other structures near 3.9, 4.1, and 4.4 GeV/c^2. No evidence for Y(4260) -> D Dbar is observed, leading to an upper limit of B(Y(4260) -> D Dbar)/B(Y(4260) -> J/psi pi+ pi-) < 1.0 at 90 % confidence level.

The BABAR Collaboration; B. Aubert

2007-11-14T23:59:59.000Z

134

Optimising the neutron environment of Radiation Portal Monitors: a computational optimisation study  

E-Print Network [OSTI]

Efficient and reliable detection of radiological or nuclear threats is a crucial part of national and international efforts to prevent terrorist activities. Radiation Portal Monitors (RPMs), which are deployed worldwide, are intended to interdict smuggled fissile material by detecting emissions of neutrons and gamma rays. However, considering the range and variety of threat sources, vehicular and shielding scenarios, and that only a small signature is present, it is important that the design of the RPMs allows these signatures to be accurately differentiated from the environmental background. Using Monte-Carlo neutron-transport simulations of a model helium-3 detector system we have conducted a parameter study to identify the optimum combination of detector shielding and collimation that maximises the sensitivity of RPMs. These structures, which could be simply and cost-effectively added to existing RPMs, can improve the detector response by more than a factor of two relative to an unmodified, bare design. Fu...

Gilbert, Mark R; Packer, Lee W

2015-01-01T23:59:59.000Z

135

STUDY OF THE RADIATION HARDNESS OF VCSEL AND PIN K.K. GAN, W. FERNANDO, H.P. KAGAN, R.D. KASS, A. LAW,  

E-Print Network [OSTI]

that the main radiation effect is bulk damage in the VCSEL and PIN with the displacement of atoms. After five and VCSEL arrays coupled to radiation-hard ASICs produced for the current pixel optical link [5], the DORIC1 STUDY OF THE RADIATION HARDNESS OF VCSEL AND PIN ARRAYS K.K. GAN, W. FERNANDO, H.P. KAGAN, R

Gan, K. K.

136

The National Center for Radioecology (NCoRE): A Network of Excellence for Environmental and Human Radiation Risk Reduction - 13365  

SciTech Connect (OSTI)

Radioecology in the United States can be traced back to the early 1950's when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a graduate education training program for radioecology. Recently, NCoRE hosted a workshop to identify the immediate needs for science-driven discoveries, tool development and the generation of scientific data to support the legislative decision-making process for remediation strategies, long-term monitoring of radiologically- contaminated sites and protection of human health and the environment. Some of the immediate strategic research needs were identified in the fields of functional genomics for determining low-dose effects, improved low-level dosimetry, and mixed (radiological and chemical) contaminant studies. Longer term strategic research and tool development areas included development of radioecology case study sites, comprehensive decision-making tools, consequence response actions, and optimized scenario based ecosystem modeling. A summary of the NCoRE workshop findings related to waste management needs and priority areas will be presented in this paper. (authors)

Kuhne, W.W.; Jannik, G.T.; Farfan, E.B.; Knox, A.S.; Mayer, J.J.; Murray, A.M. [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)] [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)

2013-07-01T23:59:59.000Z

137

Human radiation studies: Remembering the early years. Oral history of John W. Healy, November 28, 1994  

SciTech Connect (OSTI)

This document provides a transcript of an interview with John W. Healy concerning his recollections of measuring radioactive effluents at Hanford. Included are comments concerning the `Green Run`, other radioiodine releases, and a release of radioruthenium.

NONE

1995-05-01T23:59:59.000Z

138

Radiation exposure and central nervous system cancers: A case-control study among workers at two nuclear facilities  

SciTech Connect (OSTI)

A nested case-control study was conducted among workers employed between 1943 and 1977 at two nuclear facilities to investigate the possible association of primary malignant neoplasms of the central nervous system (CNS) with occupational exposure to ionizing radiation from external and internal sources. Eighty-nine white male and female workers, who according to the information on death certificates dies of primary CNS cancers, were identified as cases. Four matched controls were selected for each case. External radiation exposure data were available from film badge readings for individual workers, whereas radiation dose to lung from internally deposited radionuclides, mainly uranium, was estimated from area and personnel monitoring data and was used in analyses in lieu of the dose to the brain. Matched sets were included in the analyses only if information was available for the case and at least one of the corresponding controls. Thus, the analyses of external radiation included 27 cases and 90 matched controls, and 47 cases and 120 matched controls were analyzed for the effects of radiation from internally deposited uranium. No association was observed between deaths fron CNS cancers and occupational exposure to ionizing radiation from external or internal sources. However, due to the small number of monitored subjects and low doses, a weak association could not be ruled out. 43 refs., 1 fig., 15 tabs.

Carpenter, A.V.; Flanders, W.D.; Frome, E.L.; Crawford-Brown, D.J.; Fry, S.A.

1987-03-01T23:59:59.000Z

139

An Input Function Estimation Method for FDG-PET Human Brain Studies 1  

E-Print Network [OSTI]

An Input Function Estimation Method for FDG-PET Human Brain Studies 1 Hongbin Guo ,2 Rosemary 85287-1804, Tel: 480-965-8002, Fax: 480-965-4160 Email addresses: hb guo@asu.edu (Hongbin Guo), renaut

Renaut, Rosemary

140

Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study  

SciTech Connect (OSTI)

Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

Brooks, Jennifer D., E-mail: brooksj@mskcc.org [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Boice, John D. [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States)] [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Reiner, Anne S. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bernstein, Leslie [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States)] [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States); John, Esther M. [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States)] [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, IA (United States)] [Department of Epidemiology, University of Iowa, Iowa City, IA (United States); Mellemkjaer, Lene [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark)] [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark); Knight, Julia A. [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada)] [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada); Thomas, Duncan C.; Haile, Robert W. [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Capanu, Marinela; Bernstein, Jonine L. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shore, Roy E. [Department of Environmental Medicine, New York University, New York, NY (United States) [Department of Environmental Medicine, New York University, New York, NY (United States); Radiation Effects Research Foundation, Hiroshima (Japan)

2012-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

A Phase I Clinical and Pharmacology Study Using Amifostine as a Radioprotector in Dose-escalated Whole Liver Radiation Therapy  

SciTech Connect (OSTI)

Purpose: Diffuse intrahepatic tumors are difficult to control. Whole-liver radiotherapy has been limited by toxicity, most notably radiation-induced liver disease. Amifostine is a prodrug free-radical scavenger that selectively protects normal tissues and, in a preclinical model of intrahepatic cancer, systemic amifostine reduced normal liver radiation damage without compromising tumor effect. We hypothesized that amifostine would permit escalation of whole-liver radiation dose to potentially control microscopic disease. We also aimed to characterize the pharmacokinetics of amifostine and its active metabolite WR-1065 to optimize timing of radiotherapy. Methods and Materials: We conducted a radiation dose-escalation trial for patients with diffuse, intrahepatic cancer treated with whole-liver radiation and intravenous amifostine. Radiation dose was assigned using the time-to-event continual reassessment method. A companion pharmacokinetic study was performed. Results: Twenty-three patients were treated, with a maximum dose of 40 Gy. Using a logistical regression model, compared with our previously treated patients, amifostine increased liver tolerance by 3.3 {+-} 1.1 Gy (p = 0.007) (approximately 10%) with similar response rates. Peak concentrations of WR-1065 were 25 {mu}M with an elimination half-life of 1.5 h; these levels are consistent with radioprotective effects of amifostine in patients. Conclusion: These findings demonstrate for the first time that amifostine is a normal liver radioprotector. They further suggest that it may be useful to combine amifostine with fractionated or stereotactic body radiation therapy for patients with focal intrahepatic cancer.

Feng, Mary, E-mail: maryfeng@umich.edu [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States); Smith, David E. [Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (United States); Normolle, Daniel P. [Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania (United States)] [Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Knol, James A. [Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States); Pan, Charlie C.; Ben-Josef, Edgar [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States); Lu Zheng; Feng, Meihua R.; Chen Jun [Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (United States); Ensminger, William [Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States); Lawrence, Theodore S. [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, School of Medicine, University of Michigan, Ann Arbor, Michigan (United States)

2012-08-01T23:59:59.000Z

142

A new parameterization of canopy spectral response to incident solar radiation: case study with hyperspectral data from pine dominant forest  

E-Print Network [OSTI]

A new parameterization of canopy spectral response to incident solar radiation: case study, FIN-00014 Helsinki, Finland c Finnish Forest Research Institute, Suonenjoki Research Station, FIN-77600 Suonenjoki, Finland d VTT Automation, Remote Sensing Group, FIN-02044 VTT, Finland Received 27

Myneni, Ranga B.

143

Applied Radiation and Isotopes 58 (2003) 333338 Study of air pollutants in Hong Kong using energy dispersive  

E-Print Network [OSTI]

Applied Radiation and Isotopes 58 (2003) 333­338 Study of air pollutants in Hong Kong using energy were located within the area defined by vehicular emissions. As such, the main air pollutant monitoring site also fell into this same identified area, so the main air pollutant could also be vehicular

Yu, K.N.

144

Appendix G: Radiation HYDROGEN ATOM  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix G: Radiation #12;#12;P P P E E E N NN HYDROGEN ATOM DEUTERIUM ATOM TRITIUM ATOM HYDROGEN

Pennycook, Steve

145

Appendix A: Radiation HYDROGEN ATOM  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix A: Radiation #12;P P P E E E N NN HYDROGEN ATOM DEUTERIUM ATOM TRITIUM ATOM HYDROGEN

Pennycook, Steve

146

Potential of Hybrid Computational Phantoms for Retrospective Heart Dosimetry After Breast Radiation Therapy: A Feasibility Study  

SciTech Connect (OSTI)

Purpose: Current retrospective cardiovascular dosimetry studies are based on a representative patient or simple mathematic phantoms. Here, a process of patient modeling was developed to personalize the anatomy of the thorax and to include a heart model with coronary arteries. Methods and Materials: The patient models were hybrid computational phantoms (HCPs) with an inserted detailed heart model. A computed tomography (CT) acquisition (pseudo-CT) was derived from HCP and imported into a treatment planning system where treatment conditions were reproduced. Six current patients were selected: 3 were modeled from their CT images (A patients) and the others were modelled from 2 orthogonal radiographs (B patients). The method performance and limitation were investigated by quantitative comparison between the initial CT and the pseudo-CT, namely, the morphology and the dose calculation were compared. For the B patients, a comparison with 2 kinds of representative patients was also conducted. Finally, dose assessment was focused on the whole coronary artery tree and the left anterior descending coronary. Results: When 3-dimensional anatomic information was available, the dose calculations performed on the initial CT and the pseudo-CT were in good agreement. For the B patients, comparison of doses derived from HCP and representative patients showed that the HCP doses were either better or equivalent. In the left breast radiation therapy context and for the studied cases, coronary mean doses were at least 5-fold higher than heart mean doses. Conclusions: For retrospective dose studies, it is suggested that HCP offers a better surrogate, in terms of dose accuracy, than representative patients. The use of a detailed heart model eliminates the problem of identifying the coronaries on the patient's CT.

Moignier, Alexandra, E-mail: alexandra.moignier@irsn.fr [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Derreumaux, Sylvie; Broggio, David; Beurrier, Julien [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Chea, Michel; Boisserie, Gilbert [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)] [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France); Franck, Didier; Aubert, Bernard [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Mazeron, Jean-Jacques [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)] [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)

2013-02-01T23:59:59.000Z

147

Study of the Exclusive Initial State RadiationProduction of the D \\bar D System  

SciTech Connect (OSTI)

A study of exclusive production of the D{bar D} system through initial-state radiation is performed in a search for charmonium states, where D = D{sup 0} or D{sup +}. The D{sup 0} mesons are reconstructed in the D{sup 0} {yields} K{sup -}{pi}{sup +}, D{sup 0} {yields} K{sup -}{pi}{sup +}{pi}{sup 0}, and D{sup 0} {yields} K{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -} decay modes. The D{sup +} is reconstructed through the D{sup +} {yields} K{sup -}{pi}{sup +}{pi}{sup +} decay mode. The analysis makes use of an integrated luminosity of 288.5 fb{sup -1} collected by the BABAR experiment. The D{bar D} mass spectrum shows a clear {psi}(3770) signal. Further structures appear in the 3.9 and 4.1 GeV/c{sup 2} regions. No evidence is found for Y(4260) decays to D{bar D}, implying an upper limit {Beta}(Y(4260) {yields} D{bar D})/{Beta}(Y(4260) {yields} J/{psi}{pi}{sup +}{pi}{sup -}) < 7.6 (95% confidence level).

Aubert, B.

2006-09-07T23:59:59.000Z

148

Study of cloud properties from single-scattering, radiative forcing, and retrieval perspectives  

E-Print Network [OSTI]

This dissertation reports on three different yet related topics in light scattering computation, radiative transfer simulation, and remote sensing implementation, regarding the cloud properties and the retrieval of cloud properties from satellite...

Lee, Yong-Keun

2009-06-02T23:59:59.000Z

149

Coupled forward-adjoint monte carlo simulations of radiative transport for the study of optical probe design in heterogeneous tissues  

E-Print Network [OSTI]

approximation to the radiative transport equation [3, 7, 15,form of the radiative transport equation (RTE) assumed to

Hayakawa, Carole K.; Spanier, Jerome; Venugopalan, Vasan

2007-01-01T23:59:59.000Z

150

Is there any beam yet. Uses of synchrotron radiation in the in situ study of electrochemical interfaces  

SciTech Connect (OSTI)

The advantages of employing synchrotron radiation for the in situ study of electrochemical interfaces are discussed with emphasis on the techniques of surface EXAFS (extended X-ray absorption fine structure) and X-ray standing waves. The principles behind the techniques are briefly considered followed by a discussion of recent experimental results. Examples include the study of under potentially deposited metallic monolayers, polymer films on electrodes, and in situ measurement of adsorption isotherms. The authors conclude with an assessment of future directions.

Abruna, H.D.; White, J.H.; Albarelli, M.J.; Bommarito, G.M.; Bedzyk, M.J.; McMillan, M.

1988-12-15T23:59:59.000Z

151

Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from  

E-Print Network [OSTI]

Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from Birth to 2 Carolina, Chapel Hill, North Carolina 27599-7510 Brain development in the first 2 years after birth and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain

Utah, University of

152

A study of heat distribution in human skin: use of Infrared Thermography  

E-Print Network [OSTI]

A study of heat distribution in human skin: use of Infrared Thermography Domoina Ratovoson, Franck of this study is to be able to act quickly on body burns, to avoid propagating lesions due to heat diffusion the temperature change using an infra-red camera. Blood circulation in the veins was seen to clearly influence

Paris-Sud XI, Université de

153

Improved Imaged-derived Input Function for Study of Human Brain FDG-PET  

E-Print Network [OSTI]

Improved Imaged-derived Input Function for Study of Human Brain FDG-PET Hongbin Guo, Rosemary tomography (PET) studies. Two time windows can be recognized in the time activity curve measured from the compartmental model for FDG PET [5]. Index Terms Quantification of FDG PET, Automated Image-derived input

Renaut, Rosemary

154

Experimental study of variations in background radiation and the effect on Nuclear Car Wash sensitivity  

SciTech Connect (OSTI)

Error rates in a cargo screening system such as the Nuclear Car Wash [1-7] depend on the standard deviation of the background radiation count rate. Because the Nuclear Car Wash is an active interrogation technique, the radiation signal for fissile material must be detected above a background count rate consisting of cosmic, ambient, and neutron-activated radiations. It was suggested previously [1,6] that the Corresponding negative repercussions for the sensitivity of the system were shown. Therefore, to assure the most accurate estimation of the variation, experiments have been performed to quantify components of the actual variance in the background count rate, including variations in generator power, irradiation time, and container contents. The background variance is determined by these experiments to be a factor of 2 smaller than values assumed in previous analyses, resulting in substantially improved projections of system performance for the Nuclear Car Wash.

Church, J; Slaughter, D; Norman, E; Asztalos, S; Biltoft, P

2007-02-07T23:59:59.000Z

155

Parameter studies of candidate lattices for the 1-2 GeV synchrotron radiation source  

SciTech Connect (OSTI)

This document discusses the implications of various collective phenomena on the required performance of candidate lattices for the LBL 1 to 2 GeV Synchrotron Radiation Source. The performance issues considered include bunch length, emittance growth, and beam lifetime. In addition, the possible use of the 1 to 2 GeV Synchrotron Radiation Source as a high-gain FEL is explored briefly. Generally, the differences between lattices are minor. It appears that the most significant feature distinguishing the various alternatives will be the beam lifetime.

Zisman, M.S.

1986-01-13T23:59:59.000Z

156

An experimental apparatus for study of direct {\\beta}-radiation conversion for energy harvesting  

E-Print Network [OSTI]

This paper introduces the development and testing of an experimental apparatus for characterization of a direct charging nuclear battery. The battery consists of a parallel-plates capacitor which is charged in a vacuum by the current of {\\beta}-radiation particles (electrons) emitted from a radioisotope. A 63Ni radioisotope with an activity of 15mCi that produces a 20pA current was selected as the radiation source. The apparatus is unique in its design, having ultra-low leakage current and a few options for charge measurements. Preliminary results of a few tests are presented to demonstrate the capabilities of the apparatus.

Haim, Y; deBotton, G

2014-01-01T23:59:59.000Z

157

According to the Canadian Electricity Association's (CEA) 2004 Canadian Electricity Human Resource Study (HR Study)  

E-Print Network [OSTI]

According to the Canadian Electricity Association's (CEA) 2004 Canadian Electricity Human Resource and grow the electricity supply. Other industry realities such as the need to build and replace and increase within the electricity sector. The ability of educational and training institutions to adequately

158

Combined Treatment Effects of Radiation and Immunotherapy: Studies in an Autochthonous Prostate Cancer Model  

SciTech Connect (OSTI)

Purpose: To optimize the combination of ionizing radiation and cellular immunotherapy using a preclinical autochthonous model of prostate cancer. Methods and Materials: Transgenic mice expressing a model antigen under a prostate-specific promoter were treated using a platform that integrates cone-beam CT imaging with 3-dimensional conformal therapy. Using this technology we investigated the immunologic and therapeutic effects of combining ionizing radiation with granulocyte/macrophage colony-stimulating factor-secreting cellular immunotherapy for prostate cancer in mice bearing autochthonous prostate tumors. Results: The combination of ionizing radiation and immunotherapy resulted in a significant decrease in pathologic tumor grade and gross tumor bulk that was not evident with either single-modality therapy. Furthermore, combinatorial therapy resulted in improved overall survival in a preventive metastasis model and in the setting of established micrometastases. Mechanistically, combined therapy resulted in an increase of the ratio of effector-to-regulatory T cells for both CD4 and CD8 tumor-infiltrating lymphocytes. Conclusions: Our preclinical model establishes a potential role for the use of combined radiation-immunotherapy in locally advanced prostate cancer, which warrants further exploration in a clinical setting.

Wada, Satoshi [Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Harris, Timothy J.; Tryggestad, Erik [Department of Radiation Oncology and Molecular Radiation Sciences, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Yoshimura, Kiyoshi [Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Zeng, Jing [Department of Radiation Oncology and Molecular Radiation Sciences, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Yen, Hung-Rong; Getnet, Derese; Grosso, Joseph F.; Bruno, Tullia C. [Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); De Marzo, Angelo M. [Department of Pathology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); and others

2013-11-15T23:59:59.000Z

159

THERMOHALINE INSTABILITIES INSIDE STARS: A SYNTHETIC STUDY INCLUDING EXTERNAL TURBULENCE AND RADIATIVE LEVITATION  

SciTech Connect (OSTI)

We have derived a new expression for the thermohaline mixing coefficient in stars, including the effects of radiative levitation and external turbulence, by solving Boussinesq equations in a nearly incompressible stratified fluid with a linear approximation. It is well known that radiative levitation of individual elements can lead to their accumulation in specific stellar layers. In some cases, it can induce important effects on the stellar structure. Here we confirm that this accumulation is moderated by thermohaline convection due to the resulting inverse {mu}-gradient. The new coefficient that we have derived shows that the effect of radiative accelerations on the thermohaline instability itself is small. This effect must however be checked in all computations. We also confirm that the presence of large horizontal turbulence can reduce or even suppress the thermohaline convection. These results are important as they concern all the cases of heavy element accumulation in stars. Computations of radiative diffusion must be revisited to include thermohaline convection and its consequences. It may be one of the basic reasons for the fact that the observed abundances are always smaller than those predicted by pure atomic diffusion. In any case, these processes have to compete with rotation-induced mixing, but this competition is more complex than previously thought due to their mutual interaction.

Vauclair, Sylvie; Theado, Sylvie, E-mail: sylvie.vauclair@irap.omp.eu [Universite de Toulouse, UPS-OMP and CNRS, Institut de Recherche en Astrophysique et Planetologie, 14 avenue Edouard Belin, F-31400 Toulouse (France)

2012-07-01T23:59:59.000Z

160

Appendix F. Radiation Annual Site Environmental Report  

E-Print Network [OSTI]

from natural and human-made sources. People are exposed to naturally occurring radiation constantlyAppendix F. Radiation #12;Annual Site Environmental Report Appendix F. Radiation F-3 Appendix F. Radiation This appendix presents basic facts about radiation. The information is intended to be a basis

Pennycook, Steve

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

A Comparative Study of Amyloid Fibril Formation by Residues 1519 of the Human Calcitonin Hormone: A  

E-Print Network [OSTI]

A Comparative Study of Amyloid Fibril Formation by Residues 1519 of the Human Calcitonin Hormone highly ordered fibrils, similar to those formed by the entire hormone sequence. However-sheet amyloid fibril. We observe that the most important chemical interactions contributing to the stability

Haspel, Nurit

162

An Ankle-Foot Emulation System for the Study of Human Walking Biomechanics  

E-Print Network [OSTI]

An Ankle-Foot Emulation System for the Study of Human Walking Biomechanics Samuel K. Au Peter. A lack of understanding of the ankle-foot biomechanics and the dynamic interaction between an amputee and a prosthesis is one of the main obstacles in the development of a biomimetic ankle-foot prosthesis

Herr, Hugh

163

KEEPING THE FUTURE BRIGHT 2004 Canadian Electricity Human Resource Sector Study  

E-Print Network [OSTI]

supply 8 Electricity consumption 9 Supply and demand projections 9 Electricity exports and importsKEEPING THE FUTURE BRIGHT 2004 Canadian Electricity Human Resource Sector Study #12;This project Electricity Association The Canadian Electricity Association (CEA), founded in 1891, is the national forum

164

Observing Human Motion Using Far-Infrared (FLIR) Camera Some Preliminary Studies  

E-Print Network [OSTI]

Observing Human Motion Using Far-Infrared (FLIR) Camera ­ Some Preliminary Studies Janez Pers or FLIR cameras) are getting more and and more avail- able for civilian use. They are already used in in or re- motesensing classification systems rely on nonvisual sensors (e.g. FLIR or LADAR). The main

Kovacic, Stanislav

165

Int. J. Human-Computer Studies 63 (2005) 436451 Developing creativity, motivation, and  

E-Print Network [OSTI]

, engineering, education, and computer science to present opportunities to enhance creativity, motivationInt. J. Human-Computer Studies 63 (2005) 436­451 Developing creativity, motivation, and self May 2005 Abstract Developing learning experiences that facilitate self-actualization and creativity

Burleson, Winslow S.

166

DEVELOPMENT OF A LOW-COST ROBOTIC MANIPULATOR AND ITS APPLICATION TO HUMAN MOTOR CONTROL STUDIES  

E-Print Network [OSTI]

DEVELOPMENT OF A LOW-COST ROBOTIC MANIPULATOR AND ITS APPLICATION TO HUMAN MOTOR CONTROL STUDIES C of the experimental results seen with more expensive systems. KEY WORDS Robotics, Manipulator, Motor Learning, a robotic planar manipulator has been used for this purpose [4] [5]. Such systems make use of direct

Moussavi, Zahra M. K.

167

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model  

E-Print Network [OSTI]

Cerebral autoregulation and gas exchange studied using a human cardiopulmonary model K. Lu,1 J. W autoregulation, brain gas ex- change, and their interaction by means of a mathematical model. We have previously of intracranial dynamics. However, their models did not include gas transport in brain tissue and thus can

168

Connectivity and landscape patterns in human dominated landscape: a case study with the common frog Rana  

E-Print Network [OSTI]

Connectivity and landscape patterns in human dominated landscape: a case study with the common frog, Université de Savoie, Bâtiment Belledonne, 73376 Le Bourget du Lac, France Abstract Landscape connectivity is considered a key issue for biodiversity conservation and for the maintenance of natural ecosystems stability

Paris-Sud XI, Université de

169

Study of the spatial coherence of high order harmonic radiation generated from pre-formed plasma plumes  

SciTech Connect (OSTI)

A study of the spatial coherence of the high order harmonic radiation generated by the interaction of 45 fs Ti:sapphire laser beam with carbon (graphite) plasma plume has been carried out using Young's double slit interferometry. It is observed that the spatial coherence varies with harmonic order, laser focal spot size in plasma plume, and peaks at an optimal spot size. It is also observed that the spatial coherence is higher when the laser pulse is focused before the plasma plume than when focused after the plume, and it decreases with increase in the harmonic order. The optimum laser parameters and the focusing conditions to achieve good spatial coherence with high harmonic conversion have been identified, which is desirable for practical applications of the harmonic radiation.

Kumar, M.; Singhal, H.; Chakera, J. A.; Naik, P. A.; Khan, R. A.; Gupta, P. D. [Laser Plasma Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, M.P. (India)

2013-07-21T23:59:59.000Z

170

Preliminary studies and tests of semiconductors for their use as nuclear radiation detectors  

E-Print Network [OSTI]

of the semiconductors which were used in the tests~ and from Hughes Ines of Culver City, California, who provided a set of diodes of a type that had been sucessfully used as a radiation detector. 1 1 See article by Salzberg and Siegal of Airborne Instru- ments... that each semiconductor junction has a different breakdown point and has a different thermal noise pulse versus temperature characteristic. Silicon diodes were selected for tests because of their low thermal noise char- acteristics. The experimenter...

Willis, Giles Whitehurst

2012-06-07T23:59:59.000Z

171

Risk of Low Dose/Low Dose Rate Ionizing Radiation to Humans Symposium at the EMS 2009 Annual Meeting - September 2006  

SciTech Connect (OSTI)

The low dose symposium thoughtfully addressed controversy of risk from low dose radiation exposure, hormesis and radon therapy. The stem cell symposium cogently considered the role of DNA damage and repair in hematopoietic stem cells underlying aging and malignancy and provocatively presented evidence that stem cells may have distinct morphologies and replicative properties, as well as special roles in cancer initiation. In the epigenetics symposium, studies illustrated the long range interaction of epigenetic mechanisms, the roles of CTCF and BORIS in region/specific regulation of epigenetic processes, the impact of DNA damage on epigenetic processes as well as links between epigenetic mechanisms and early nutrition and bystander effects.

Morgan, William F.; von Borstel, Robert C.; Brenner,; Redpath, J. Leslie; Erickson, Barbra E.; Brooks,

2009-11-12T23:59:59.000Z

172

Numerical and simulation study of terahertz radiation generation by laser pulses propagating in the extraordinary mode in magnetized plasma  

SciTech Connect (OSTI)

A one-dimensional numerical model for studying terahertz radiation generation by intense laser pulses propagating, in the extraordinary mode, through magnetized plasma has been presented. The direction of the static external magnetic field is perpendicular to the polarization as well as propagation direction of the laser pulse. A transverse electromagnetic wave with frequency in the terahertz range is generated due to the presence of the magnetic field. Further, two-dimensional simulations using XOOPIC code show that the THz fields generated in plasma are transmitted into vacuum. The fields obtained via simulation study are found to be compatible with those obtained from the numerical model.

Jha, Pallavi; Kumar Verma, Nirmal [Department of Physics, University of Lucknow, Lucknow-226007 (India)

2014-06-15T23:59:59.000Z

173

Radiation dose fractionation studies with hypoxic cell radiosensitizers using a murine tumor. [X-ray; mice  

SciTech Connect (OSTI)

The ability of five nitroimidazoles, metronidazole (MET), misonidazole (MISO), desmethymisonidazole (DMM), SR 2508 and SR 2555, to sensitize the KHT sarcoma to radiation treatment has been compared for drug doses in the range 0-1.5 g/Kg. Single radiation doses or two different daily fractionation schedules (4 fractions of 5 Gy each or 7 fraction of 3 Gy each) were used; the tumor cell survival was determined using either an in vivo or in vitro colony assay. Each radiation (100 kVp X rays at 11 Gy/min) treatment was given locally, 60-70 min (MET) or 30-40 min (other drugs) after either intraperitoneal (MET, MISO, DMM) or intraveous (SR 2508, SR 2555) injection of the drugs; these times have been shown to be optimum for this tumor. For the single doses and both fractionation schedules the tumor cell survival, following the irradiation treatment, declined as the drug dose increased in the range 0 to 0.75 g/Kg for all the drugs, but above this dose level a plateau was reached and the amount of sensitization remained essentially constant. In this plateau region the reduction in survival achieved was similar for single doses and 5 Gy fraction but was less for 3 Gy fractions, indicating that sensitization was smaller for the smaller dose fractions. For the 4 x 5 Gy fractionation schedule the plateau level of survival was lowest for MISO, DMM and SR 2508, slightly higher for SR 2555 and much higher for MET. For the 3 Gy fractions SR 2508 appeared slightly less effective than MISO and DMM.

Hill, R.P.

1982-03-01T23:59:59.000Z

174

Does Local Recurrence of Prostate Cancer After Radiation Therapy Occur at the Site of Primary Tumor? Results of a Longitudinal MRI and MRSI Study  

SciTech Connect (OSTI)

Purpose: To determine if local recurrence of prostate cancer after radiation therapy occurs at the same site as the primary tumor before treatment, using longitudinal magnetic resonance (MR) imaging and MR spectroscopic imaging to assess dominant tumor location. Methods and Materials: This retrospective study was HIPAA compliant and approved by our Committee on Human Research. We identified all patients in our institutional prostate cancer database (1996 onward) who underwent endorectal MR imaging and MR spectroscopic imaging before radiotherapy for biopsy-proven prostate cancer and again at least 2 years after radiotherapy (n = 124). Two radiologists recorded the presence, location, and size of unequivocal dominant tumor on pre- and postradiotherapy scans. Recurrent tumor was considered to be at the same location as the baseline tumor if at least 50% of the tumor location overlapped. Clinical and biopsy data were collected from all patients. Results: Nine patients had unequivocal dominant tumor on both pre- and postradiotherapy imaging, with mean pre- and postradiotherapy dominant tumor diameters of 1.8 cm (range, 1-2.2) and 1.9 cm (range, 1.4-2.6), respectively. The median follow-up interval was 7.3 years (range, 2.7-10.8). Dominant recurrent tumor was at the same location as dominant baseline tumor in 8 of 9 patients (89%). Conclusions: Local recurrence of prostate cancer after radiation usually occurs at the same site as the dominant primary tumor at baseline, suggesting supplementary focal therapy aimed at enhancing local tumor control would be a rational addition to management.

Arrayeh, Elnasif; Westphalen, Antonio C. [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Kurhanewicz, John [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Roach, Mack [Department of Radiation Oncology, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Jung, Adam J. [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Carroll, Peter R. [Department of Urology, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Coakley, Fergus V., E-mail: fergus.coakley@radiology.ucsf.edu [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States)

2012-04-01T23:59:59.000Z

175

A study of the response of a gas ionization chamber to different sources of ionizing radiation  

E-Print Network [OSTI]

; is the effective average energy to produce one pair (for values, see Table I). Charged particles produced by ionization lose their energy rather quickly in multiple collisions with the gas molecules and assume the thermal energy distribution of the gas. When... of aluminum extrusion ionization chambers to this kind of radiation was investigated. Also, since the TAMU counter is a prototype (1 in x 7in x 7in) of the chambers installed at CDF (1 in x 84in x 84in), the pad-to-wire signal ratio had to be measured...

Zamble?-Die?guez, Filiberto Edmundo

1988-01-01T23:59:59.000Z

176

Sensitivity Study of the Effects of Mineral Dust Particle Nonsphericity and Thin Cirrus Clouds on MODIS Dust Optical Depth Retrievals and Direct Radiative Forcing Calculations  

E-Print Network [OSTI]

A special challenge posed by mineral dust aerosols is associated with their predominantly nonspherical particle shapes. In the present study, the scattering and radiative properties for nonspherical mineral dust aerosols at violet-to-blue (0.412, 0...

Feng, Qian

2011-10-21T23:59:59.000Z

177

Aging and Gas Filtration Studies in the ATLAS Transition Radiation Tracker  

E-Print Network [OSTI]

The Transition Radiation Tracker (TRT) is one of three particle tracking detectors of the ATLAS Inner Detector whose goal is to exploit the highly exciting new physics potential at CERN's next accelerator, the so-called Large Hadron Collider (LHC). The TRT consists of 370000 straw proportional tubes of 4 mm diameter with a 30 micron anode wire, which will be operated with a Xe/CO2/O2 gas mixture at a high voltage of approximately 1.5 kV. This detector enters a new area that requires it to operate at unprecedented high rates and integrated particle fluxes. Full functionality of the detector over the lifetime (10 years) of the experiment is demanded. Aging of gaseous detectors is a term for the degradation of detector performance during exposure to ionizing radiation. This phenomenon involves very complex physical and chemical processes that are induced by pollution originating from very small amounts of silicon-based substances in some components of the gas system. This work presents a review of previous aging...

Sprachmann, Gerald; Stri, Herbert

2006-01-01T23:59:59.000Z

178

Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study  

SciTech Connect (OSTI)

The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to translate the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

Ronald L. Boring; John A. Forester; Andreas Bye; Vinh N. Dang; Erasmia Lois

2010-06-01T23:59:59.000Z

179

Comparison study of the sensitivities of some indices of DDT exposure in human blood and urine  

SciTech Connect (OSTI)

Although exposure to DDT (2,2-bis(p-chlorophenyl1)1,1,1,-trichloroethane) is not normally associated with fatality or chronic adverse effects to human life, it is a known hazard to the ecosystem. Blood levels of DDT and some of its derivatives have been used to assess extent of exposure or the body load of DDT in humans. In experimental studies, ingestion of DDT has been associated with reduced liver stores of vitamin A, and increased serum levels of vitamin A. The same study also revealed a significant correlation of vitamin A and DDE serum levels. Generally an increase in excreted 17-B-hydroxycortisone has been associated with DDT exposure. Increased excretion of 6-B-hydroxycortisol has been noted in workers who were involved in the formulation of DDT. The objective of this study was to compare the sensitivities of some indices of DDT exposure in humans. The indices which were compared are serum vitamin A and DDE levels and urinary 17-B-hydroxycortisol.

Nhachi, C.F.B.; Loewenson, R. (Univ. of Zimbabwe (South Africa))

1989-10-01T23:59:59.000Z

180

Study of Interfacial Interactions Using Thing Film Surface Modification: Radiation and Oxidation Effects in Materials  

SciTech Connect (OSTI)

Interfaces play a key role in dictating the long-term stability of materials under the influence of radiation and high temperatures. For example, grain boundaries affect corrosion by way of providing kinetically favorable paths for elemental diffusion, but they can also act as sinks for defects and helium generated during irradiation. Likewise, the retention of high-temperature strength in nanostructured, oxide-dispersion strengthened steels depends strongly on the stoichiometric and physical stability of the (Y, Ti)-oxide particles/matrix interface under radiation and high temperatures. An understanding of these interfacial effects at a fundamental level is important for the development of materials for extreme environments of nuclear reactors. The goal of this project is to develop an understanding stability of interfaces by depositing thin films of materials on substrates followed by ion irradiation of the film-substrate system at elevated temperatures followed by post-irradiation oxidation treatments. Specifically, the research will be performed by depositing thin films of yttrium and titanium (~500 nm) on Fe-12%Cr binary alloy substrate. Y and Ti have been selected as thin-film materials because they form highly stable protective oxides layers. The Fe-12%Cr binary alloy has been selected because it is representative of ferritic steels that are widely used in nuclear systems. The absence of other alloying elements in this binary alloy would allow for a clearer examination of structures and compositions that evolve during high-temperature irradiations and oxidation treatments. The research is divided into four specific tasks: (1) sputter deposition of 500 nm thick films of Y and Ti on Fe-12%Cr alloy substrates, (2) ion irradiation of the film-substrate system with 2MeV protons to a dose of 2 dpa at temperatures of 300C, 500C, and 700C, (3) oxidation of as-deposited and ion-irradiated samples in a controlled oxygen environment at 500C and 700C, (4) multi-scale computational modeling involving first- principle molecular dynamics (FPMD) and coarse-grained dissipative particle dynamics (DPD) approaches to develop theories underlying the evolution and stability of structures and phases. Samples from Tasks 1 to 3 (above) will be rigorously characterized and analyzed using scanning electron microscopy, Auger electron microscopy, x-ray diffraction, Rutherford back scatter spectroscopy, and transmission electron microscopy. Expected outcomes of the experimental work include a quantitative understanding film-substrate interface mixing, evolution of defects and other phases at the interface, interaction of interfaces with defects, and the ability of the Y and Ti films to mitigate irradiation-assisted oxidation. The aforementioned experimental work will be closely coupled with multi-scale molecular dynamics (MD) modeling to understand the reactions at the surface, the transport of oxidant through the thin film, and the stabilities of the deposited thin films under radiation and oxidation. Simulations of materials property changes under conditions of radiation and oxidation require multiple size domains and a different simulation scheme for each of these domains. This will be achieved by coupling the FPMD and coarse-grained kinetic Monte Carlo (KMC). This will enable the comparison of the results of each simulation approach with the experimental results.

Sridharan, Kumar; Zhang, Jinsuo

2014-01-09T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

A Phase 1 Study of Everolimus + Weekly Cisplatin + Intensity Modulated Radiation Therapy in Head-and-Neck Cancer  

SciTech Connect (OSTI)

Purpose: Elevated expression of eukaryotic protein synthesis initiation factor 4E (eIF4E) in histologically cancer-free margins of resected head and neck squamous cell carcinomas (HNSCCs) is mediated by mammalian target of rapamycin complex 1 (mTORC1) and has been associated with increased risk of disease recurrence. Preclinically, inhibition of mTORC1 with everolimus sensitizes cancer cells to cisplatin and radiation. Methods and Materials: This was single-institution phase 1 study to establish the maximum tolerated dose of daily everolimus given with fixed dose cisplatin (30 mg/m{sup 2} weekly 6) and concurrent intensity modulated radiation therapy for patients with locally and/or regionally advanced head-and-neck cancer. The study had a standard 3 + 3 dose-escalation design. Results: Tumor primary sites were oral cavity (4), salivary gland (4), oropharynx (2), nasopharynx (1), scalp (1), and neck node with occult primary (1). In 4 of 4 cases in which resected HNSCC surgical pathology specimens were available for immunohistochemistry, elevated expression of eIF4E was observed in the cancer-free margins. The most common grade ?3 treatment-related adverse event was lymphopenia (92%), and dose-limiting toxicities (DLTs) were mucositis (n=2) and failure to thrive (n=1). With a median follow up of 19.4 months, 2 patients have experienced recurrent disease. The maximum tolerated dose was everolimus 5 mg/day. Conclusions: Head-and-neck cancer patients tolerated everolimus at therapeutic doses (5 mg/day) given with weekly cisplatin and intensity modulated radiation therapy. The regimen merits further evaluation, especially among patients who are status post resection of HNSCCs that harbor mTORC1-mediated activation of eIF4E in histologically negative surgical margins.

Fury, Matthew G. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States); Lee, Nancy Y. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Sherman, Eric; Ho, Alan L. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States); Rao, Shyam [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Heguy, Adriana [Department of Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shen, Ronglai [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Korte, Susan; Lisa, Donna [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Ganly, Ian; Patel, Snehal; Wong, Richard J.; Shaha, Ashok; Shah, Jatin [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Haque, Sofia [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Katabi, Nora [Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Pfister, David G. [Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Medicine, Weill Cornell Medical College, New York, New York (United States)

2013-11-01T23:59:59.000Z

182

Development and Validation of a Heart Atlas to Study Cardiac Exposure to Radiation Following Treatment for Breast Cancer  

SciTech Connect (OSTI)

Purpose: Cardiac toxicity is an important sequela of breast radiotherapy. However, the relationship between dose to cardiac structures and subsequent toxicity has not been well defined, partially due to variations in substructure delineation, which can lead to inconsistent dose reporting and the failure to detect potential correlations. Here we have developed a heart atlas and evaluated its effect on contour accuracy and concordance. Methods and Materials: A detailed cardiac computed tomography scan atlas was developed jointly by cardiology, cardiac radiology, and radiation oncology. Seven radiation oncologists were recruited to delineate the whole heart, left main and left anterior descending interventricular branches, and right coronary arteries on four cases before and after studying the atlas. Contour accuracy was assessed by percent overlap with gold standard atlas volumes. The concordance index was also calculated. Standard radiation fields were applied. Doses to observer-contoured cardiac structures were calculated and compared with gold standard contour doses. Pre- and post-atlas values were analyzed using a paired t test. Results: The cardiac atlas significantly improved contour accuracy and concordance. Percent overlap and concordance index of observer-contoured cardiac and gold standard volumes were 2.3-fold improved for all structures (p < 0.002). After application of the atlas, reported mean doses to the whole heart, left main artery, left anterior descending interventricular branch, and right coronary artery were within 0.1, 0.9, 2.6, and 0.6 Gy, respectively, of gold standard doses. Conclusions: This validated University of Michigan cardiac atlas may serve as a useful tool in future studies assessing cardiac toxicity and in clinical trials which include dose volume constraints to the heart.

Feng, Mary, E-mail: maryfeng@umich.ed [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Moran, Jean M. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Koelling, Todd [Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chughtai, Aamer [Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chan, June L.; Freedman, Laura; Hayman, James A.; Jagsi, Reshma; Jolly, Shruti; Larouere, Janice; Soriano, Julie; Marsh, Robin; Pierce, Lori J. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)

2011-01-01T23:59:59.000Z

183

Radiation environment simulations at the Tevatron, studies of the beam profile and measurement of the Bc meson mass  

SciTech Connect (OSTI)

The description of a computer simulation of the CDF detector at Fermilab and the adjacent accelerator parts is detailed, with MARS calculations of the radiation background in various elements of the model due to the collision of beams and machine-related losses. Three components of beam halo formation are simulated for the determination of the principal source of radiation background in CDF due to beam losses. The effect of a collimator as a protection for the detector is studied. The simulation results are compared with data taken by a CDF group. Studies of a 150 GeV Tevatron proton beam are performed to investigate the transverse diffusion growth and distribution. A technique of collimator scan is used to scrape the beam under various experimental conditions, and computer programs are written for the beam reconstruction. An average beam halo growth speed is given and the potential of beam tail reconstruction using the collimator scan is evaluated. A particle physics analysis is conducted in order to detect the B{sub c} {yields} J/{psi}{pi} decay signal with the CDF Run II detector in 360 pb{sup -1} of data. The cut variables and an optimization method to determine their values are presented along with a criterion for the detection threshold of the signal. The mass of the B{sub c} meson is measured with an evaluation of the significance of the signal.

Nicolas, Ludovic Y.

2005-09-01T23:59:59.000Z

184

Curcumin Regulates Low-Linear Energy Transfer {gamma}-Radiation-Induced NF{kappa}B-Dependent Telomerase Activity in Human Neuroblastoma Cells  

SciTech Connect (OSTI)

Purpose: We recently reported that curcumin attenuates ionizing radiation (IR)-induced survival signaling and proliferation in human neuroblastoma cells. Also, in the endothelial system, we have demonstrated that NF{kappa}B regulates IR-induced telomerase activity (TA). Accordingly, we investigated the effect of curcumin in inhibiting IR-induced NF{kappa}B-dependent hTERT transcription, TA, and cell survival in neuroblastoma cells. Methods and Materials: SK-N-MC or SH-SY5Y cells exposed to IR and treated with curcumin (10-100 nM) with or without IR were harvested after 1 h through 24 h. NF{kappa}B-dependent regulation was investigated either by luciferase reporter assays using pNF{kappa}B-, pGL3-354-, pGL3-347-, or pUSE-I{kappa}B{alpha}-Luc, p50/p65, or RelA siRNA-transfected cells. NF{kappa}B activity was analyzed using an electrophoretic mobility shift assay and hTERT expression using the quantitative polymerase chain reaction. TA was determined using the telomerase repeat amplification protocol assay and cell survival using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltertrazolium bromide and clonogenic assay. Results: Curcumin profoundly inhibited IR-induced NF{kappa}B. Consequently, curcumin significantly inhibited IR-induced TA and hTERT mRNA at all points investigated. Furthermore, IR-induced TA is regulated at the transcriptional level by triggering telomerase reverse transcriptase (TERT) promoter activation. Moreover, NF{kappa}B becomes functionally activated after IR and mediates TA upregulation by binding to the {kappa}B-binding region in the promoter region of the TERT gene. Consistently, elimination of the NF{kappa}B-recognition site on the telomerase promoter or inhibition of NF{kappa}B by the I{kappa}B{alpha} mutant compromises IR-induced telomerase promoter activation. Significantly, curcumin inhibited IR-induced TERT transcription. Consequently, curcumin inhibited hTERT mRNA and TA in NF{kappa}B overexpressed cells. Furthermore, curcumin enhanced the IR-induced inhibition of cell survival. Conclusions: These results strongly suggest that curcumin inhibits IR-induced TA in an NF{kappa}B dependent manner in human neuroblastoma cells.

Aravindan, Natarajan, E-mail: naravind@ouhsc.ed [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Veeraraghavan, Jamunarani; Madhusoodhanan, Rakhesh; Herman, Terence S. [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Natarajan, Mohan [Department of Otolaryngology, Head and Neck Surgery, University of Texas Health Sciences Center at San Antonio, San Antonio, TX (United States)

2011-03-15T23:59:59.000Z

185

Radiation: Radiation Control (Indiana)  

Broader source: Energy.gov [DOE]

It is the policy of the state to encourage the constructive uses of radiation and to control its harmful effects. This section contains regulations pertaining to the manufacture, use,...

186

The dynamical mass ejection from binary neutron star mergers: Radiation-hydrodynamics study in general relativity  

E-Print Network [OSTI]

We perform radiation-hydrodynamics simulations of binary neutron star mergers in numerical relativity on the Japanese "K" supercomputer, taking into account neutrino cooling and heating by an updated leakage-plus-transfer scheme for the first time. Neutron stars are modeled by three modern finite-temperature equations of state (EOS) developed by Hempel and his collaborators. We find that the electron fraction has a broad distribution due to the weak processes and shock heating. The properties of the ejecta such as total mass, average electron fraction, and thermal energy depend strongly on the EOS. Only for a soft EOS (the so-called SFHo), the ejecta mass exceeds $0.01M_{\\odot}$. In this case, the electron fraction has a broad distribution which is well-suited for the production of the solar-like $r$-process abundance. For the other stiff EOS (DD2 and TM1), for which a long-lived massive neutron star is formed after the merger, the ejecta mass is smaller than $0.01M_{\\odot}$, although broad electron-fraction ...

Sekiguchi, Yuichiro; Kyutoku, Koutarou; Shibata, Masaru

2015-01-01T23:59:59.000Z

187

The evolved circumbinary disk of AC Her: a radiative transfer, interferometric and mineralogical study  

E-Print Network [OSTI]

We aim to constrain the structure of the circumstellar material around the post-AGB binary and RV Tauri pulsator AC Her. We want to constrain the spatial distribution of the amorphous as well as of the crystalline dust. We present very high-quality mid-IR interferometric data that were obtained with MIDI/VLTI. We analyse the MIDI data and the full SED, using the MCMax radiative transfer code, to find a good structure model of AC Her's circumbinary disk. We include a grain size distribution and midplane settling of dust self-consistently. The spatial distribution of crystalline forsterite in the disk is investigated with the mid-IR features, the 69~$\\mu$m band and the 11.3~$\\mu$m signatures in the interferometric data. All the data are well fitted. The inclination and position angle of the disk are well determined at i=50+-8 and PA=305+-10. We firmly establish that the inner disk radius is about an order of magnitude larger than the dust sublimation radius. Significant grain growth has occurred, with mm-sized ...

Hillen, M; Menu, J; Van Winckel, H; Min, M; Mulders, G D

2015-01-01T23:59:59.000Z

188

The NCI Radiation Research Program: Grant portfolio and radiation  

E-Print Network [OSTI]

models (89 animals no human subject material, 21 use both) ­ 109 utilize rodent models ­ 2 have canine and R37s). Of those that utilize radiation: · 6 use tissue culture models only · 110 utilize animal subjects · 39 use human subjects or human subject materials only. #12;Dose and Dosimetry · The majority

189

Studies on Shiga toxin type 1 mediated tumor necrosis factor synthesis in a human monocytic cell line  

E-Print Network [OSTI]

STUDIES ON SHIGA TOXIN TYPE 1 MEDIATED TUMOR NECROSIS FACTOR SYNTHESIS IN A HUMAN MONOCYTIC CELL LINE A Thesis by RAMESH SAKIRI Submitted to the Office of Graduate Studies of Texas AII M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 1997 Major Subject: Biology STUDIES ON SHIGA TOXIN TYPE 1 MEDIATED TUMOR NECROSIS FACTOR SYNTHESIS IN A HUMAN MONOCYTIC CELL LINE A Thesis by RAMESH SAKIRI Submitted to Texas A8M University in partial...

Sakiri, Ramesh

1997-01-01T23:59:59.000Z

190

Twenty-channel bolometer array for studying impurity radiation and transport in the TCS field-reversed configuration  

SciTech Connect (OSTI)

A bolometer array diagnostic has been developed for the University of Washington Translation, Confinement, and Sustainment (TCS) field-reversed configuration (FRC) experiment in order to measure radially resolved total radiated power per unit length of the FRC. This will provide radiation energy loss information, useful in power balance and impurity studies. The 20-element photodiode bolometer will be mounted at the midplane of the TCS cylindrical vacuum chamber to view the rotating magnetic field (RMF) generated FRC plasma. Key features of this new bolometer array are (1) extensive electrical shielding against the RMF, (2) robust electrical isolation, (3) trans-impedance amplifiers using a microcoax interface at the array and a fiber optic interface to the screen room, and (4) a custom glass-on-metal socket for the 20-element photodiode chip to ensure high vacuum compatibility. The bolometer array can be retracted behind a gate valve using a stepper motor to protect it during vacuum chamber bakeout. The slit assembly housing is interchangeable to provide flexibility for the viewing sightlines.

Kostora, M. R.; Hsu, S. C.; Wurden, G. A. [Physics Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

2006-10-15T23:59:59.000Z

191

Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats  

SciTech Connect (OSTI)

Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

2009-04-01T23:59:59.000Z

192

Space Radiation and Cataracts (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2009: Eleanor Blakely, radiation biologist of the Life Sciences Division at Lawrence Berkeley National Laboratory, has been a scientist at Berkeley Lab since 1975. She is studying the effect of radiation on cataracts which concerns not only cancer patients, but also astronauts. As astronauts spend increasingly longer time in space, the effects of cosmic radiation exposure will become an increasingly important health issue- yet there is little human data on these effects. Blakely reviews this emerging field and the contributions made at Berkeley Lab

Blakely, Eleanor

2011-04-28T23:59:59.000Z

193

RADIATION MONITORING  

E-Print Network [OSTI]

of Monitoring for Radiation Protection of Workers" in ICRPNo. 9, in "Advances in Radiation Protection and Dosimetry inDosimetry f o r Stray Radiation Monitoring on the CERN S i t

Thomas, R.H.

2010-01-01T23:59:59.000Z

194

Study of two G-protein coupled receptor variants of human trace amine-associated receptor 5  

E-Print Network [OSTI]

Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. A systematic detergent screen showed that ...

Wang, Xiaoqiang

195

Computational study of radiation damage and impurity effects in iron based alloys  

E-Print Network [OSTI]

Molecular dynamics techniques are used to explore metals at an atomic level. The focus of the studies is the effects of irradiation on a metallic system. Ion surface bombardment effects, bulk cascades and interaction ...

Galloway, Graham

2014-11-27T23:59:59.000Z

196

A Phase I Study of Short-Course Accelerated Whole Brain Radiation Therapy for Multiple Brain Metastases  

SciTech Connect (OSTI)

Purpose: To define the maximum tolerated dose (MTD) of a SHort-course Accelerated whole brain RadiatiON therapy (SHARON) in the treatment of patients with multiple brain metastases. Methods and Materials: A phase 1 trial in 4 dose-escalation steps was designed: 12 Gy (3 Gy per fraction), 14 Gy (3.5 Gy per fraction), 16 Gy (4 Gy per fraction), and 18 Gy (4.5 Gy per fraction). Eligibility criteria included patients with unfavorable recursive partitioning analysis (RPA) class > or =2 with at least 3 brain metastases or metastatic disease in more than 3 organ systems, and Eastern Cooperative Oncology Group (ECOG) performance status {<=}3. Treatment was delivered in 2 days with twice-daily fractionation. Patients were treated in cohorts of 6-12 to define the MTD. The dose-limiting toxicity (DLT) was defined as any acute toxicity {>=}grade 3, according to the Radiation Therapy Oncology Group scale. Information on the status of the main neurologic symptoms and quality of life were recorded. Results: Characteristics of the 49 enrolled patients were as follows: male/female, 30/19; median age, 66 years (range, 23-83 years). ECOG performance status was <3 in 46 patients (94%). Fourteen patients (29%) were considered to be in recursive partitioning analysis (RPA) class 3. Grade 1-2 acute neurologic (26.4%) and skin (18.3%) toxicities were recorded. Only 1 patient experienced DLT (neurologic grade 3 acute toxicity). With a median follow-up time of 5 months (range, 1-23 months), no late toxicities have been observed. Three weeks after treatment, 16 of 21 symptomatic patients showed an improvement or resolution of presenting symptoms (overall symptom response rate, 76.2%; confidence interval 0.95: 60.3-95.9%). Conclusions: Short-course accelerated radiation therapy in twice-daily fractions for 2 consecutive days is tolerated up to a total dose of 18 Gy. A phase 2 study has been planned to evaluate the efficacy on overall survival, symptom control, and quality of life indices.

Caravatta, Luciana; Deodato, Francesco; Ferro, Marica [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Macchia, Gabriella, E-mail: gmacchia@rm.unicatt.it [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Massaccesi, Mariangela [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Cilla, Savino [Medical Physics Unit, Fondazione di Ricerca e Cura 'Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy)] [Medical Physics Unit, Fondazione di Ricerca e Cura 'Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Padula, Gilbert D.A. [Department of Radiation Oncology, The Lacks Cancer Center Saint Mary's Health Care, Grand Rapids, Michigan (United States)] [Department of Radiation Oncology, The Lacks Cancer Center Saint Mary's Health Care, Grand Rapids, Michigan (United States); Mignogna, Samantha; Tambaro, Rosa [Department of Palliative Therapies, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Palliative Therapies, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Carrozza, Francesco [Department of Oncology, A. Cardarelli Hospital, Campobasso (Italy)] [Department of Oncology, A. Cardarelli Hospital, Campobasso (Italy); Flocco, Mariano [Madre Teresa di Calcutta Hospice, Larino (Italy)] [Madre Teresa di Calcutta Hospice, Larino (Italy); Cantore, Giampaolo [Department of Neurological Sciences, Istituto Neurologico Mediterraneo Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli (Italy)] [Department of Neurological Sciences, Istituto Neurologico Mediterraneo Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli (Italy); Scapati, Andrea [Department of Radiation Oncology, 'San Francesco' Hospital, Nuoro (Italy)] [Department of Radiation Oncology, 'San Francesco' Hospital, Nuoro (Italy); Buwenge, Milly [Department of Radiotherapy, Mulago Hospital, Kampala (Uganda)] [Department of Radiotherapy, Mulago Hospital, Kampala (Uganda); and others

2012-11-15T23:59:59.000Z

197

he Impact of Primary Marine Aerosol on Atmospheric Chemistry, Radiation and Climate: A CCSM Model Development Study  

SciTech Connect (OSTI)

This project examined the potential large-scale influence of marine aerosol cycling on atmospheric chemistry, physics and radiative transfer. Measurements indicate that the size-dependent generation of marine aerosols by wind waves at the ocean surface and the subsequent production and cycling of halogen-radicals are important but poorly constrained processes that influence climate regionally and globally. A reliable capacity to examine the role of marine aerosol in the global-scale atmospheric system requires that the important size-resolved chemical processes be treated explicitly. But the treatment of multiphase chemistry across the breadth of chemical scenarios encountered throughout the atmosphere is sensitive to the initial conditions and the precision of the solution method. This study examined this sensitivity, constrained it using high-resolution laboratory and field measurements, and deployed it in a coupled chemical-microphysical 3-D atmosphere model. First, laboratory measurements of fresh, unreacted marine aerosol were used to formulate a sea-state based marine aerosol source parameterization that captured the initial organic, inorganic, and physical conditions of the aerosol population. Second, a multiphase chemical mechanism, solved using the Max Planck Institute for Chemistry??s MECCA (Module Efficiently Calculating the Chemistry of the Atmosphere) system, was benchmarked across a broad set of observed chemical and physical conditions in the marine atmosphere. Using these results, the mechanism was systematically reduced to maximize computational speed. Finally, the mechanism was coupled to the 3-mode modal aerosol version of the NCAR Community Atmosphere Model (CAM v3.6.33). Decadal-scale simulations with CAM v.3.6.33, were run both with and without reactive-halogen chemistry and with and without explicit treatment of particulate organic carbon in the marine aerosol source function. Simulated results were interpreted (1) to evaluate influences of marine aerosol production on the microphysical properties of aerosol populations and clouds over the ocean and the corresponding direct and indirect effects on radiative transfer; (2) atmospheric burdens of reactive halogen species and their impacts on O3, NOx, OH, DMS, and particulate non-sea-salt SO42-; and (3) the global production and influences of marine-derived particulate organic carbon. The model reproduced major characteristics of the marine aerosol system and demonstrated the potential sensitivity of global, decadal-scale climate metrics to multiphase marine-derived components of Earth??s troposphere. Due to the combined computational burden of the coupled system, the currently available computational resources were the limiting factor preventing the adequate statistical analysis of the overall impact that multiphase chemistry might have on climate-scale radiative transfer and climate.

Keene, William C. [University of Virginia] [University of Virginia; Long, Michael S. [University of Virginia] [University of Virginia

2013-05-20T23:59:59.000Z

198

Cognitive Function Before and After Intensity-Modulated Radiation Therapy in Patients With Nasopharyngeal Carcinoma: A Prospective Study  

SciTech Connect (OSTI)

Purpose: To evaluate the effects of radiation therapy (RT) on neurocognitive function in patients with nasopharyngeal carcinoma (NPC). Methods and Materials: Thirty patients with NPC treated with intensity-modulated RT were included. Dose-volume histograms of the temporal lobes were obtained in every patient. Neurocognitive tests were administered individually to each patient 1 day before initiation of RT and at least 12 months after completion of RT. Cognitive functioning status was evaluated as change in scores over time. Results: Among the total of 30 patients, 23 patients (76.7%) had significantly lower post-RT cognitive functioning scores compared with their pre-RT scores (p = 0.033). The cognitive functioning scores had significantly declined in the domains of short-term memory, language abilities, and list-generating fluency (p = 0.020, 0.023, and 0.001, respectively). Compared with patients with a mean dose to the temporal lobes of 36 Gy or less, patients with a mean dose of greater than 36 Gy had a significantly greater reduction in cognitive functioning scores (p = 0.017). Patients in whom V60 of the temporal lobes (i.e., the percentage of the temporal lobe volume that had received >60 Gy) was greater than 10% also had a greater reduction in cognitive functioning scores than those in whom V60 was 10% or less (p = 0.039). Conclusions: The results of our study indicated that RT could have deleterious effects on cognitive function in patients with NPC. Efforts should be made to reduce the radiation dose and irradiated volume of temporal lobes without compromising the coverage of target volume.

Hsiao, Kuan-Yin [Department of Radiation Oncology, E-Da Hospital, Kaohsiung, Taiwan (China); Department of Medical Imaging and Radiological Science, I-Shou University, Kaohsiung, Taiwan (China); Yeh, Shyh-An, E-mail: yehsa@hotmail.co [Department of Radiation Oncology, E-Da Hospital, Kaohsiung, Taiwan (China); Department of Medical Imaging and Radiological Science, I-Shou University, Kaohsiung, Taiwan (China); Chang, Chiung-Chih [Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan (China)

2010-07-01T23:59:59.000Z

199

Impact of Concomitant Chemotherapy on Outcomes of Radiation Therapy for Head-and-Neck Cancer: A Population-Based Study  

SciTech Connect (OSTI)

Purpose: Clinical trials have shown that the addition of chemotherapy to radiation therapy (RT) improves survival in advanced head-and-neck cancer. The objective of this study was to describe the effectiveness of concomitant chemoradiation therapy (C-CRT) in routine practice. Methods and Materials: This was a population-based cohort study. Electronic records of treatment from all provincial cancer centers were linked to a population--based cancer registry to describe the adoption of C-CRT for head-and-neck cancer patients in Ontario, Canada. The study population was then divided into pre- and postadoption cohorts, and their outcomes were compared. Results: Between 1992 and 2008, 18,867 patients had diagnoses of head-and-neck cancer in Ontario, of whom 7866 (41.7%) were treated with primary RT. The proportion of primary RT cases that received C-CRT increased from 2.2% in the preadoption cohort (1992-1998) to 39.3% in the postadoption cohort (2003-2008). Five-year survival among all primary RT cases increased from 43.6% in the preadoption cohort to 51.8% in the postadoption cohort (P<.001). Over the same period, treatment-related hospital admissions increased significantly, but there was no significant increase in treatment-related deaths. Conclusions: C-CRT was widely adopted in Ontario after 2003, and its adoption was temporally associated with an improvement in survival.

Gupta, Shlok; Kong, Weidong [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Booth, Christopher M. [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Department of Community Health and Epidemiology, Queens University, Kingston, Ontario (Canada)

2014-01-01T23:59:59.000Z

200

Incentives for and methodology of the study on radiation induced glass wasteform degradation  

SciTech Connect (OSTI)

It is necessary to take into account the vagueness of ionization damage in evaluating the results for reliable prediction of the long-term behavior of glasses containing beta gamma nuclides. In support of the project on immobilization of Cs-137 and Sr-90 after HLW partitioning, the present study is devoted to justifying further investigations on the subject. The key points of the proposed approach are illustrated by some preliminary experimental data.

Nechaev, A.F.; Suvorov, O.A. [St. Petersburg Inst. of Tech. (Russian Federation). Dept. of Nuclear Engineering; Aloy, A.S.; Faddeev, I.S. [V.G. Khlopin Radium Inst., St. Petersburg (Russian Federation). Div. of Nuclear Waste Management and Environmental Research

1993-12-31T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Cornell Roundtable on Environmental Studies Topics The Arrogance of Humanism? : What Is the Role of the Humanities in the Environmental  

E-Print Network [OSTI]

College); Nancy Menning (Religious Studies, Ithaca College); Sarah Ensor (English, Cornell); Amy Kohout

Angenent, Lars T.

202

Study of the radiative decay J/psi. -->. gamma. eta. pi. /sup +/. pi. /sup -/  

SciTech Connect (OSTI)

The Mark III collaboration has performed a high statistics study of the reaction J/psi ..-->.. ..gamma..eta..pi../sup +/..pi../sup -/, with two different final states of the eta, eta ..-->.. ..gamma gamma.. and eta ..-->.. ..pi../sup 0/..pi../sup +/..pi../sup -/. Both modes have a broad structure from 1.2 to 1.9 GeV/c/sup 2/ and two structures, which decay via delta/sup + -/..pi../sup - +/, delta/sup + -/ ..-->.. eta..pi../sup + -/, are identified at 1.28 and 1.39 GeV/c/sup 2/. No signal is observed in the iota(1440) signal region.

Becker, J.J.; Blaylock, G.T.; Bolton, T.; Brown, J.S.; Bunnell, K.O.; Burnett, T.H.; Cassell, R.E.; Coffman, D.; Cook, V.; Coward, D.H.

1987-02-01T23:59:59.000Z

203

Carbon contamination and oxidation of Au surfaces under extreme ultraviolet radiation: An x-ray photoelectron spectroscopy study  

E-Print Network [OSTI]

Carbon contamination and oxidation of Au surfaces under extreme ultraviolet radiation: An x 2012) Extreme ultraviolet (EUV) radiation-induced carbon contamination and oxidation of Au surfaces modification during EUV exposure. XPS analysis showed that total carbon contamination (C 1s peak

Harilal, S. S.

204

Radiation damage studies of lasers and photodiodes for use in Multi-Gb/s optical data links  

E-Print Network [OSTI]

Neutron and pion irradiation and annealing data from semiconductor lasers and photodiodes for use in 10 Gb/s datalinks are presented. These components are found to be generally more radiation resistant than their older counterparts. Radiation damage in lasers has been modeled to allow extrapolation of the results obtained to the final application.

Troska, Jan; Seif El Nasr-Storey, Sarah; Stejskal, Pavel; Sigaud, Christophe; Soos, Csaba; Vasey, Francois

2011-01-01T23:59:59.000Z

205

Study of radiative blast waves generated on the Z-beamlet laser.  

SciTech Connect (OSTI)

This document describes the original goals of the project to study the Vishniac Overstability on blast waves produced using the Z-Beamlet laser facility as well as the actual results. The proposed work was to build on earlier work on the facility and result in the best characterized set of data for such phenomena in the laboratory. To accomplish the goals it was necessary to modify the existing probe laser at the facility so that it could take multiple images over the course of 1-2 microseconds. Troubles with modifying the probe laser are detailed as well as the work that went into said modifications. The probe laser modification ended up taking the entire length of the project and were the major accomplishment of the research.

Edens, Aaron D.; Schwarz, Jens

2012-02-01T23:59:59.000Z

206

Appendix E. Radiation Annual Site Environmental Report--2011  

E-Print Network [OSTI]

and biological systems. Radiation comes from natural and human-made sources. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon in air; potassium in food and waterAppendix E. Radiation #12;#12;Annual Site Environmental Report--2011 Appendix E. Radiation E-3

Pennycook, Steve

207

Atmospheric Radiation Measurement (ARM) Data from Black Forest Germany for the Convective and Orographically Induced Precipitation Study (COPS)  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The primary goal of the ARM Program is to improve the treatment of cloud and radiation physics in global climate models in order to improve the climate simulation capabilities of these models. ARM maintains four major, permanent sites for data collection and deploys the ARM Mobile Facility (AMF) to other sites as determined. In 2007 the AMF operated in the Black Forest region of Germany as part of the Convective and Orographically Induced Precipitation Study (COPS). Scientists studied rainfall resulting from atmospheric uplift (convection) in mountainous terrain, otherwise known as orographic precipitation. This was part of a six -year duration of the German Quantitative Precipitation Forecasting (QPF) Program. COPS was endorsed as a Research and Development Project by the World Weather Research Program. This program was established by the World Meteorological Organization to develop improved and cost-effective forecasting techniques, with an emphasis on high-impact weather. A large collection of data plots based on data streams from specific instruments used at Black Forest are available via a link from ARM's Black Forest site information page. Users will be requested to create a password, but the plots and the data files in the ARM Archive are free for viewing and downloading.

208

Spatially and Temporally Resolved Studies of the Human Microbiome (2011 JGI User Meeting)  

SciTech Connect (OSTI)

The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Rob Knight of the University of Colorado gives a presentation on "Spatially and Temporally Resolved Studies of the Human Microbiome" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

Knight, Rob [University of Colorado] [University of Colorado

2011-03-23T23:59:59.000Z

209

Spatially and Temporally Resolved Studies of the Human Microbiome (2011 JGI User Meeting)  

ScienceCinema (OSTI)

The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Rob Knight of the University of Colorado gives a presentation on "Spatially and Temporally Resolved Studies of the Human Microbiome" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

Knight, Rob [University of Colorado

2011-06-03T23:59:59.000Z

210

A novel approach in electron beam radiation therapy of lips carcinoma: A Monte Carlo study  

SciTech Connect (OSTI)

Purpose: Squamous cell carcinoma (SCC) is commonly treated by electron beam radiotherapy (EBRT) followed by a boost via brachytherapy. Considering the limitations associated with brachytherapy, in this study, a novel boosting technique in EBRT of lip carcinoma using an internal shield as an internal dose enhancer tool (IDET) was evaluated. An IDET is referred to a partially covered internal shield located behind the lip. It was intended to show that while the backscattered electrons are absorbed in the portion covered with a low atomic number material, they will enhance the target dose in the uncovered area. Methods: Monte-Carlo models of 6 and 8 MeV electron beams were developed using BEAMnrc code and were validated against experimental measurements. Using the developed models, dose distributions in a lip phantom were calculated and the effect of an IDET on target dose enhancement was evaluated. Typical lip thicknesses of 1.5 and 2.0 cm were considered. A 5 Multiplication-Sign 5 cm{sup 2} of lead covered by 0.5 cm of polystyrene was used as an internal shield, while a 4 Multiplication-Sign 4 cm{sup 2} uncovered area of the shield was used as the dose enhancer. Results: Using the IDET, the maximum dose enhancement as a percentage of dose at d{sub max} of the unshielded field was 157.6% and 136.1% for 6 and 8 MeV beams, respectively. The best outcome was achieved for lip thickness of 1.5 cm and target thickness of less than 0.8 cm. For lateral dose coverage of planning target volume, the 80% isodose curve at the lip-IDET interface showed a 1.2 cm expansion, compared to the unshielded field. Conclusions: This study showed that a boost concomitant EBRT of lip is possible by modifying an internal shield into an IDET. This boosting method is especially applicable to cases in which brachytherapy faces limitations, such as small thicknesses of lips and targets located at the buccal surface of the lip.

Shokrani, Parvaneh [Medical Physics and Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); Baradaran-Ghahfarokhi, Milad [Medical Physics and Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran and Medical Radiation Engineering Department, Faculty of Advanced Sciences and Technologies, Isfahan University, Isfahan 81746-73441 (Iran, Islamic Republic of); Zadeh, Maryam Khorami [Medical Physics Department, School of Medicine, Ahwaz Jundishapour University of Medical Sciences, Ahwaz 15794-61357 (Iran, Islamic Republic of)

2013-04-15T23:59:59.000Z

211

Study of the Exclusive Initial-State Radiation Production of the $D \\bar D$ System  

E-Print Network [OSTI]

A study of exclusive production of the $D \\bar D$ system through initial-state r adiation is performed in a search for charmonium states, where $D=D^0$ or $D^+$. The $D^0$ mesons are reconstructed in the $D^0 \\to K^- \\pi^+$, $D^0 \\to K^- \\pi^+ \\pi^0$, and $D^0 \\to K^- \\pi^+ \\pi^+ \\pi^-$ decay modes. The $D^+$ is reconstructed through the $D^+ \\to K^- \\pi^+ \\pi^+$ decay mode. The analysis makes use of an integrated luminosity of 288.5 fb$^{-1}$ collected by the BaBar experiment. The $D \\bar D$ mass spectrum shows a clear $\\psi(3770)$ signal. Further structures appear in the 3.9 and 4.1 GeV/$c^2$ regions. No evidence is found for Y(4260) decays to $D \\bar D$, implying an up per limit $\\frac{\\BR(Y(4260)\\to D \\bar D)}{\\BR(Y(4260)\\to J/\\psi \\pi^+ \\pi^-)} < 7.6$ (95 % confidence level).

The BABAR Collaboration; B. Aubert

2006-07-27T23:59:59.000Z

212

Radiation-Damage Study of a Monocrystalline Tungsten Positron Converter X. Artru, R. Kirsch, IPN, Lyon, France; R. Chehab, LAL, Orsay, France;  

E-Print Network [OSTI]

Radiation-Damage Study of a Monocrystalline Tungsten Positron Converter X. Artru, R. Kirsch, IPN tested on a 0.3 mm thick tungsten monocrystal exposed dur- ing 6 months to the 30 Gev incident electron and the corresponding enhancement in pair production [1, 3]. Their use in linear colliders (LC), where high beam

Paris-Sud XI, Universit de

213

This paper describes the Structure-Mapping Engine (SME), a cognitive simulation program for studying human analogical  

E-Print Network [OSTI]

This paper describes the Structure-Mapping Engine (SME), a cognitive simulation program for studying human analogical processing. SME is based on Gentner's Structure-Mapping theory of analogy enhances cognitive simulation studies by simplifying experimentation. Furthermore, SME is very efficient

Forbus, Kenneth D.

214

Int. J. Human--Computer Studies (1998) 48, 51--67 Learning organizational roles for negotiated search in  

E-Print Network [OSTI]

Int. J. Human--Computer Studies (1998) 48, 51--67 Learning organizational roles for negotiated@bbtech.com This paper presents studies in learning a form of organizational knowledge called organizational roles-agent parametric design system called L-TEAM where a set of heterogeneous agents learn their organizational roles

Massachusetts at Amherst, University of

215

A preliminary study of the linear relationship between monthly averaged daily solar radiation and daily thermal amplitude in the north of Buenos Aires provence  

E-Print Network [OSTI]

Using irradiance and temperature measurements obtained at the Facultad Regional San Nicol\\'as of UTN, we performed a preliminary study of the linear relationship between monthly averaged daily solar radiation and daily thermal amplitude. The results show a very satisfactory adjustment (R = 0.848, RMS = 0.066, RMS% = 9.690 %), even taking into account the limited number of months (36). Thus, we have a formula of predictive nature, capable of estimating mean monthly solar radiation for various applications. We expect to have new data sets to expand and improve the statistical significance of these results.

Cionco, R; Rodriguez, R

2012-01-01T23:59:59.000Z

216

A Sensitivity Study on Modeling Black Carbon in Snow and its Radiative Forcing over the Arctic and Northern China  

SciTech Connect (OSTI)

Black carbon in snow (BCS) simulated in the Community Atmosphere Model (CAM5) is evaluated against measurements over Northern China and the Arctic, and its sensitivity to atmospheric deposition and two parameters that affect post-depositional enrichment is explored. The BCS concentration is overestimated (underestimated) by a factor of two in Northern China (Arctic) in the default model, but agreement with observations is good over both regions in the simulation with improvements in BC transport and deposition. Sensitivity studies indicate that uncertainty in the melt-water scavenging efficiency (MSE) parameter substantially affects BCS and its radiative forcing (by a factor of 2-7) in the Arctic through post-depositional enrichment. The MSE parameter has a relatively small effect on the magnitude of BCS seasonal cycle but can alter its phase in Northern China. The impact of the snow aging scaling factor (SAF) on BCS, partly through the post-depositional enrichment effect, shows more complex latitudinal and seasonal dependence. Similar to MSE, SAF affects more significantly the magnitude (phase) of BCS season cycle over the Arctic (Northern China). While uncertainty associated with the representation of BC transport and deposition processes in CAM5 is more important than that associated with the two snow model parameters in Northern China, the two uncertainties have comparable effect in the Arctic.

Qian, Yun; Wang, Hailong; Zhang, Rudong; Flanner, M. G.; Rasch, Philip J.

2014-06-02T23:59:59.000Z

217

Long Baseline Neutrino Experiment Target Material Radiation Damage Studies Using Energetic Protons of the Brookhaven Linear Isotope Production (BLIP) Facility  

E-Print Network [OSTI]

One of the future multi-MW accelerators is the LBNE Experiment where Fermilab aims to produce a beam of neutrinos with a 2.3 MW proton beam as part of a suite of experiments associated with Project X. Specifically, the LBNE Neutrino Beam Facility aims for a 2+ MW, 60 -120 GeV pulsed, high intensity proton beam produced in the Project X accelerator intercepted by a low Z solid target to facilitate the production of low energy neutrinos. The multi-MW level LBNE proton beam will be characterized by intensities of the order of 1.6 e+14 p/pulse, {\\sigma} radius of 1.5 -3.5 mm and a 9.8 microsecond pulse length. These parameters are expected to push many target materials to their limit thus making the target design very challenging. To address a host of critical design issues revealed by recent high intensity beam on target experience a series of experimental studies on radiation damage and thermal shock response conducted at BNL focusing on low-Z materials have been undertaken with the latest one focusing on LBNE.

Simos, N; Hurh, P; Mokhov, N; Kotsina, Z

2014-01-01T23:59:59.000Z

218

Clouds in the atmospheres of extrasolar planets. IV. On the scattering greenhouse effect of CO2 ice particles: Numerical radiative transfer studies  

E-Print Network [OSTI]

Owing to their wavelengths dependent absorption and scattering properties, clouds have a strong impact on the climate of planetary atmospheres. Especially, the potential greenhouse effect of CO2 ice clouds in the atmospheres of terrestrial extrasolar planets is of particular interest because it might influence the position and thus the extension of the outer boundary of the classic habitable zone around main sequence stars. We study the radiative effects of CO2 ice particles obtained by different numerical treatments to solve the radiative transfer equation. The comparison between the results of a high-order discrete ordinate method and simpler two-stream approaches reveals large deviations in terms of a potential scattering efficiency of the greenhouse effect. The two-stream methods overestimate the transmitted and reflected radiation, thereby yielding a higher scattering greenhouse effect. For the particular case of a cool M-type dwarf the CO2 ice particles show no strong effective scattering greenhouse eff...

Kitzmann, D; Rauer, H

2013-01-01T23:59:59.000Z

219

Multidimensional simulation studies of the SELENE FEL oscillator/buncher followed by a radiator/amplifier output scheme  

SciTech Connect (OSTI)

We analyze and present numerical simulations of the so-called electron output scheme [G. I. Erg et al., 15th Int. FEL Conf., The Hague, The Netherlands, 1993, Book of Abstracts p. 50; Preprint Budker INP 93-75] applied to the SELENE proposal of using a high power FEL to illuminate satellite solar cells. In this scheme, a first stage FEL oscillator bunches the electron beam while a second stage ``radiator`` extracts high power radiation. Our analysis suggests only in the case where the radiator employs a long, tapered undulator will the electron output scheme produce a significant increase in extraction efficiency over what is obtainable from a simple, single-stage oscillator. 1- and 2-D numerical simulations of a 1.7{mu}m FEL employing the electron output scheme show reasonably large bunching fractions ({approximately} 0.3--0.4) at the output of the oscillator stage but only {le}2% extraction efficiency from the radiator stage.

Hahn, S.J. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Fawley, W.M. [Lawrence Berkeley Lab., CA (United States)

1995-02-01T23:59:59.000Z

220

Danger radiations  

ScienceCinema (OSTI)

Le confrencier Mons.Hofert parle des dangers et risques des radiations, le contrle des zones et les prcautions prendre ( p.ex. film badge), comment mesurer les radiations etc.

None

2011-04-25T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Can We Predict Plan Quality for External Beam Partial Breast Irradiation: Results of a Multicenter Feasibility Study (Trans Tasman Radiation Oncology Group Study 06.02)  

SciTech Connect (OSTI)

Purpose: Partial breast irradiation (PBI) after lumpectomy may be an option for selected patients with early breast cancer. A feasibility study of accelerated PBI delivered using external beam 3-dimensional conformal radiation therapy (RT) was undertaken at 8 Australasian centers. The present study evaluated the impact of patient, tumor, and RT technique-related factors on the quality of RT plans as determined by the dosevolume parameters of organs at risk. Methods and Materials: Forty-eight patients were enrolled in the study. All RT plans were centrally reviewed using predefined dosimetric criteria before commencement and after completion of protocol therapy. The RT plans of 47 patients met the dosevolume constraints, and all 47 patients received PBI to a prescribed dose of 38.5 Gy in 10 fractions. The RT plan quality was determined by volumes of the ipsilateral whole breast, lung, and heart that received 50% and 95%; 30%; and 5% of the prescribed dose, respectively. Patient, tumor, and RT technique-related factors were investigated for association with the parameters of RT plan quality. Results: The ratio of the planning target volume to the ipsilateral whole-breast volume was significantly associated with the ipsilateral breast doses on multiple variable analyses. The distance of the postlumpectomy surgical cavity from the heart and lung were predictive for heart and lung doses, respectively. A distance between surgical cavity and heart of >4 cm typically resulted in <1% of the heart volume receiving 5 Gy or less. It was more difficult to meet the heart dose constraint for left-sided and medially located tumors. Conclusions: Partial breast irradiation using 3-dimensional conformal RT was feasible within the study constraints. The ratio of planning target volume to ipsilateral whole-breast volume and the distance of surgical cavity from the heart were significant predictors of the quality of treatment plan for external beam PBI.

Kron, Tomas, E-mail: Tomas.Kron@petermac.org [Peter MacCallum Cancer Centre, Departments of Radiation Oncology, Physical Sciences and Radiation Therapy, Melbourne, Victoria (Australia); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria (Australia); School of Science, Engineering and Technology, Royal Melbourne Institute of Technology University, Melbourne, Victoria (Australia); Willis, David; Link, Emma [Peter MacCallum Cancer Centre, Departments of Radiation Oncology, Physical Sciences and Radiation Therapy, Melbourne, Victoria (Australia); Lehman, Margot [Princess Alexandra Hospital, Department of Radiation Oncology, Brisbane, Queensland (Australia); Campbell, Gillian [Auckland City Hospital, Department of Radiation Oncology, Auckland (New Zealand); O'Brien, Peter [Newcastle Calvary Mater Hospital, Department of Radiation Oncology, Newcastle, NSW (Australia); Chua, Boon [Peter MacCallum Cancer Centre, Departments of Radiation Oncology, Physical Sciences and Radiation Therapy, Melbourne, Victoria (Australia); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria (Australia)

2013-11-15T23:59:59.000Z

222

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity  

SciTech Connect (OSTI)

The lens of the eye is one of the most radiosensitive tissues in the body. Ocular ionizing radiation exposure results in characteristic, dose related, progressive lens changes leading to cataract formation. While initial, early stages of lens opacification may not cause visual disability, the severity of such changes progressively increases with dose until vision is impaired and cataract extraction surgery may be required. Because of the transparency of the eye, radiation induced lens changes can easily be followed non-invasively over time. Thus, the lens provides a unique model system in which to study the effects of low dose ionizing radiation exposure in a complex, highly organized tissue. Despite this observation, considerable uncertainties remain surrounding the relationship between dose and risk of developing radiation cataract. For example, a growing number of human epidemiological findings suggest significant risk among various groups of occupationally and accidentally exposed individuals and confidence intervals that include zero dose. Nevertheless, questions remain concerning the relationship between lens opacities, visual disability, clinical cataract, threshold dose and/or the role of genetics in determining radiosensitivity. Experimentally, the response of the rodent eye to radiation is quite similar to that in humans and thus animal studies are well suited to examine the relationship between radiation exposure, genetic determinants of radiosensitivity and cataractogenesis. The current work has expanded our knowledge of the low-dose effects of X-irradiation or high-LET heavy ion exposure on timing and progression of radiation cataract and has provided new information on the genetic, molecular, biochemical and cell biological features which contribute to this pathology. Furthermore, findings have indicated that single and/or multiple haploinsufficiency for various genes involved in DNA repair and cell cycle checkpoint control, such as Atm, Brca1 or Rad9, influence cataract development and thus radiosensitivity. These observations have direct applicability to various human populations including accidentally exposed individuals, interventional medical workers, astronauts and nuclear plant workers.

Kleiman, Norman Jay [Columbia University] [Columbia University

2013-11-30T23:59:59.000Z

223

On the Possibility of an Astronomical Perspective in the Study of Human Evolution  

E-Print Network [OSTI]

The Sapient Paradox is the apparently unexplainable time delay of several ten thousand years following the arrival of Homo sapiens in Asia and Europe and before the introduction of impressive innovations with the agricultural revolution. Renfrew (2007) has suggested that the solution of the paradox has to do with changes in modes of thought that occurred with sedentism. According to Renfrew, this is a subject of study for cognitive archaeology where the final goal would be to understand the formation of the human mind. Several scholars, however, affirm that climatic change was crucial to such a revolution as it would have been very difficult to develop agriculture during the Palaeolithic. In other words, sedentism was not justified during the ice age, and that may be the solution to the paradox. It is widely accepted that climate variations were due to so-called orbital forcing, the slow periodic changes of orbital parameters of the Earth (known also as the Milankovitch theory). These and other astronomical e...

Antonello, E

2013-01-01T23:59:59.000Z

224

Abstract --Recent human pharmacological fMRI studies suggest that oxytocin (OT) is a centrally-acting  

E-Print Network [OSTI]

Abstract -- Recent human pharmacological fMRI studies suggest that oxytocin (OT) is a centrally-acting neurotransmitter important in the development and expression of trusting relationships in men and women. OT of several key interacting brain regions affected by OT neurophysiology during social trust behavior

Dascalu, Sergiu

225

Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study  

E-Print Network [OSTI]

Following previous Monte Carlo simulations, we describe in detail an example of detecting evoked visual hemodynamic responses in a human subject as a preliminary demonstration of the novel global interference cancellation ...

Zhang, Quan

226

Fermentation of pectin and cellulose to short chain fatty acids: a comparative study with humans, baboons, pigs, and rats  

E-Print Network [OSTI]

digestibility to the human results. SCFA were measured using gas chromatography. The pH was measured before and after the fermentations. The percent fiber remaining after fermentation was assayed colorimetrically. The greatest interspecies differences were...%I@ W, W, '. '" yW~, t . . . M~~~)~ '1 r FERMENTATION OF PECTIN AND CELLULOSE TO SHORT CHAIN FATTY ACIDS: A COMPARATIVE STUDY WITH HUMANS, BABOONS, PIGS, AND RATS A Thesis by LEONILDE NONITA VILLALBA IL W I Z IJ Z 4 Z 4 2 5 V Z I...

Villalba, Leonilde Nonita

1989-01-01T23:59:59.000Z

227

A study of the role of calcium and magnesium in casein micellar structure in human milk  

E-Print Network [OSTI]

pages follow the style of the Journal of ~OS Compared to bovine milk, relatively little is known about the effects of technological treatments on the individual constituents of human milk. One important constituent is the casein micelle. Human... compositions (20). The results of Lonnerdal and Forsum (19) indicate that this modification may also affect the bioavailability of trace minerals. Bovine milk contains approximately four to six times more calcium, phosphorus, and sodium and two to three...

Gallaway, Sheila Ann

1988-01-01T23:59:59.000Z

228

Mechanisms of radiation interaction with DNA: Potential implications for radiation protection  

SciTech Connect (OSTI)

The Office of Health and Environmental Research (OHER) of the US Department of Energy conducts a broad multidisciplinary research program which includes basic biophysics, biophysical chemistry, molecular and cellular biology as well as experimental animal studies and opportunistic human studies. This research is directed at understanding how low levels of radiation of various qualities produce the spectrum of biological effects that are seen for such exposures. This workshop was entitled ''Mechanisms of Radiation Interaction with DNA: Potential Implications for Radiation Protection.'' It ws jointly sponsored by the Department of Energy and the Commission of European Communities. The aim of the workshop was to review the base of knowledge in the area of mechanisms of radiation action at the DNA level, and to explore ways in which this information can be applied to the development of scientifically sound concepts and procedures for use in the field of radiation protection. The overview of research provided by this multidisciplinary group will be helpful to the Office in program planning. This report includes a summary of the presentations, extended abstracts, the meeting agenda, research recommendations, and a list of participants. Individual papers are processed separately for the data base.

Not Available

1988-01-01T23:59:59.000Z

229

RADIATION MEASUREMENTS BY BROOKHAVEN NATIONAL LABORATORY DURING THE WOODS HOLE OCEANOGRAPHIC INSTITUTION INTERCOMPARISON STUDY, MAY-JUNE 2000.  

SciTech Connect (OSTI)

The WHOI buoy radiometer intercomparison took place during May and June, 2000 at the WHOI facility. The WHOI IMET, JAMSTEC Triton, and NOAA TAO buoy systems were operated from a beach site and the Brookhaven National Laboratory set up two Portable Radiation Package systems (P01 and P02) alongside the WHOI instrumentation on the roof of the Clark Building, about 300 m away. The BNL instruments were named ''P01'' and ''P02'' and were identical. Buoy instruments were all leveled to {+-}1{degree} to horizontal. The purpose of the project was to compare the buoy systems with precision measurements so that any differences in data collection or processing would be evaluated. BNL was pleased to participate so the PRP system could be evaluated as a calibration tool. The Portable Radiation Package is an integral component of the BNL Shipboard Oceanographic and Atmospheric Radiation (SOAR) system. It is designed to make accurate downwelling radiation measurements, including the three solar irradiance components (direct normal, diffuse and global) at six narrowband channels, aerosol optical depth measurements, and broadband longwave and shortwave irradiance measurements.

REYNOLDS, R.M.; BARTHOLOMEW, M.J.; MILLER, M.A.; SMITH, S.; EDWARDS, R.

2000-12-01T23:59:59.000Z

230

Spectral signature of ice clouds in the far-infrared region: Single-scattering calculations and radiative sensitivity study  

E-Print Network [OSTI]

, a parameterization of the bulk scattering properties is developed. The radiative properties of ice cloudsSpectral signature of ice clouds in the far-infrared region: Single-scattering calculations the spectral signature of ice clouds in the far-infrared (far-IR) spectral region from 100 to 667 cm?1 (15

Baum, Bryan A.

231

Study of the interaction of C60 fullerene with human serum albumin in aqueous solution  

SciTech Connect (OSTI)

Concern about the toxicity of engineered nanoparticles, such as the prototypical nanomaterial C60 fullerene, continues to grow. While evidence continues to mount that C60 and its derivatives may pose health hazards, the specific molecular interactions of these particles with biological macromolecules require further investigation. To better understand the interaction of C60 with proteins, the protein human serum albumin (HSA) was studied in solution with C60 at C60:HSA molar ratios ranging from 1:2 to 4:1. HSA is the major protein component of blood plasma and plays a role in a variety of functions, such as the maintenance of blood pH and pressure. The C60-HSA interaction was probed by a combination of circular dichroism (CD) spectroscopy, small-angle neutron scattering (SANS) and atomistic molecular dynamics (MD) simulations to understand C60-driven changes in the structure of HSA in solution. The CD spectroscopy demonstrates that the secondary structure of the protein decreases in -helical content in response to the presence of C60. Similarly, C60 produces subtle changes in the solution conformation of HSA, as evidenced by the SANS data and MD. The data do not indicate that C60 is causing a change in the oligomerization state of the protein. Taken together results demonstrate that C60 interacts with HSA, but it does not strongly perturb the structure of the protein by unfolding it or inducing aggregation, suggesting a mechanism for transporting C60 throughout the body to accumulate in various tissues.

Li, Song [Vanderbilt University; Zhao, Xiongce [National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Mo, Yiming [ORNL; Cummings, Peter T [ORNL; Heller, William T [ORNL

2013-01-01T23:59:59.000Z

232

Inverse antagonist activities of parabens on human oestrogen-related receptor ? (ERR?): In vitro and in silico studies  

SciTech Connect (OSTI)

Parabens are p-hydroxybenzoic acid esters that have been used extensively as preservatives in foods, cosmetics, drugs and toiletries. These intact esters are commonly detected in human breast cancer tissues and other human samples, thus arousing concern about the involvement of parabens in human breast cancer. In this study, an in vitro nuclear receptor coactivator recruiting assay was developed and used to evaluate the binding activities of parabens, salicylates and benzoates via antagonist competitive binding on the human oestrogen-related receptor ? (ERR?), which is known as both a diagnostic biomarker and a treatment target of breast cancer. The results showed that all of the test parabens (methyl-, ethyl-, propyl-, butyl- and benzylparaben) possessed clear inverse antagonist activities on ERR?, with a lowest observed effect level (LOEL) of 10{sup ?7} M and the 50% relative effective concentrations (REC50) varying from 3.09 10{sup ?7} to 5.88 10{sup ?7} M, whereas the salicylates possessed much lower activities and the benzoates showed no obvious activity. In silico molecular docking analyses showed that parabens fitted well into the active site of ERR?, with hydrogen bonds forming between the p-hydroxyl group of parabens and the Glu275/Arg316 of ERR?. As the paraben levels reported in breast cancer tissues are commonly higher than the LOELs observed in this study, parabens may play some role via ERR? in the carcinogenesis of human breast cancer. In addition, parabens may have significant effects on breast cancer patients who are taking tamoxifen, as ERR? is regarded as a treatment target for tamoxifen. - Highlights: An oestrogen-related receptor ? coactivator recruiting assay was developed. Strong binding activities of parabens with oestrogen-related receptor ? were found. The paraben levels reported in breast cancer tissues were higher than their LOELs. Parabens may play some role via ERR? in the carcinogenesis of human breast cancer. Parabens may have significant effects in breast cancer patients taking tamoxifen.

Zhang, Zhaobin; Sun, Libei; Hu, Ying; Jiao, Jian; Hu, Jianying, E-mail: hujy@urban.pku.edu.cn

2013-07-01T23:59:59.000Z

233

Evaluation of multiple image-based modalities for image-guided radiation therapy (IGRT) of prostate carcinoma: A prospective study  

SciTech Connect (OSTI)

Purpose: Setup errors and prostate intrafraction motion are main sources of localization uncertainty in prostate cancer radiation therapy. This study evaluates four different imaging modalities 3D ultrasound (US), kV planar images, cone-beam computed tomography (CBCT), and implanted electromagnetic transponders (Calypso/Varian) to assess inter- and intrafraction localization errors during intensity-modulated radiation therapy based treatment of prostate cancer. Methods: Twenty-seven prostate cancer patients were enrolled in a prospective IRB-approved study and treated to a total dose of 75.6 Gy (1.8 Gy/fraction). Overall, 1100 fractions were evaluated. For each fraction, treatment targets were localized using US, kV planar images, and CBCT in a sequence defined to determine setup offsets relative to the patient skin tattoos, intermodality differences, and residual errors for each patient and patient cohort. Planning margins, following van Herk's formalism, were estimated based on error distributions. Calypso-based localization was not available for the first eight patients, therefore centroid positions of implanted gold-seed markers imaged prior to and immediately following treatment were used as a motion surrogate during treatment. For the remaining 19 patients, Calypso transponders were used to assess prostate intrafraction motion. Results: The means ({mu}), and standard deviations (SD) of the systematic ({Sigma}) and random errors ({sigma}) of interfraction prostate shifts (relative to initial skin tattoo positioning), as evaluated using CBCT, kV, and US, averaged over all patients and fractions, were: [{mu}{sub CBCT}= (-1.2, 0.2, 1.1) mm, {Sigma}{sub CBCT}= (3.0, 1.4, 2.4) mm, {sigma}{sub CBCT}= (3.2, 2.2, 2.5) mm], [{mu}{sub kV}= (-2.9, -0.4, 0.5) mm, {Sigma}{sub kV}= (3.4, 3.1, 2.6) mm, {sigma}{sub kV}= (2.9, 2.0, 2.4) mm], and [{mu}{sub US}= (-3.6, -1.4, 0.0) mm, {Sigma}{sub US}= (3.3, 3.5, 2.8) mm, {sigma}{sub US}= (4.1, 3.8, 3.6) mm], in the anterior-posterior (A/P), superior-inferior (S/I), and the left-right (L/R) directions, respectively. In the treatment protocol, adjustment of couch was guided by US images. Residual setup errors as assessed by kV images were found to be: {mu}{sub residual}= (-0.4, 0.2, 0.2) mm, {Sigma}{sub residual}= (1.0, 1.0,0.7) mm, and {sigma}{sub residual}= (2.5, 2.3, 1.8) mm. Intrafraction prostate motion, evaluated using electromagnetic transponders, was: {mu}{sub intrafxn}= (0.0, 0.0, 0.0) mm, {Sigma}{sub intrafxn}= (1.3, 1.5, 0.6) mm, and {sigma}{sub intrafxn}= (2.6, 2.4, 1.4) mm. Shifts between pre- and post-treatment kV images were: {mu}{sub kV(post-pre)}= (-0.3, 0.8, -0.2), {Sigma}{sub kV(post-pre)}= (2.4, 2.7, 2.1) mm, and {sigma}{sub kV(post-pre)}= (2.7, 3.2, 3.1) mm. Relative to skin tattoos, planning margins for setup error were within 10-11 mm for all image-based modalities. The use of image guidance was shown to reduce these margins to less than 5 mm. Margins to compensate for both residual setup (interfraction) errors as well as intrafraction motion were 6.6, 6.8, and 3.9 mm in the A/P, S/I, and L/R directions, respectively. Conclusions: Analysis of interfraction setup errors, performed with US, CBCT, planar kV images, and electromagnetic transponders, from a large dataset revealed intermodality shifts were comparable (within 3-4 mm). Interfraction planning margins, relative to setup based on skin marks, were generally within the 10 mm prostate-to-planning target volume margin used in our clinic. With image guidance, interfraction residual planning margins were reduced to approximately less than 4 mm. These findings are potentially important for dose escalation studies using smaller margins to better protect normal tissues.

Mayyas, Essa; Chetty, Indrin J.; Chetvertkov, Mikhail; Wen, Ning; Neicu, Toni; Nurushev, Teamor; Ren Lei; Pradhan, Deepak; Movsas, Benjamin; Elshaikh, Mohamed A. [Department of Radiation Oncology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, Michigan 48202 (United States); Lu Mei [Department of Public Health Sciences, Henry Ford Health System, 2799 West Grand Boulevard, Detroit Michigan 48202 (United States); Stricker, Hans [Department of Urology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit Michigan 48202 (United States)

2013-04-15T23:59:59.000Z

234

Application of the accurate mass and time tag approach in studies of the human blood lipidome  

SciTech Connect (OSTI)

We report a preliminary demonstration of the accurate mass and time (AMT) tag approach for lipidomics. Initial data-dependent LC-MS/MS analyses of human plasma, erythrocyte, and lymphocyte lipids were performed in order to identify lipid molecular species in conjunction with complementary accurate mass and isotopic distribution information. Identified lipids were used to populate initial lipid AMT tag databases containing 250 and 45 entries for those species detected in positive and negative electrospray ionization (ESI) modes, respectively. The positive ESI database was then utilized to identify human plasma, erythrocyte, and lymphocyte lipids in high-throughput quantitative LC-MS analyses based on the AMT tag approach. We were able to define the lipid profiles of human plasma, erythrocytes, and lymphocytes based on qualitative and quantitative differences in lipid abundance. In addition, we also report on the optimization of a reversed-phase LC method for the separation of lipids in these sample types.

Ding, Jie; Sorensen, Christina M.; Jaitly, Navdeep; Jiang, Hongliang; Orton, Daniel J.; Monroe, Matthew E.; Moore, Ronald J.; Smith, Richard D.; Metz, Thomas O.

2008-08-15T23:59:59.000Z

235

A 2-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated With Development of Erectile Dysfunction Following Radiation Therapy for Prostate Cancer  

SciTech Connect (OSTI)

Purpose: To identify single nucleotide polymorphisms (SNPs) associated with development of erectile dysfunction (ED) among prostate cancer patients treated with radiation therapy. Methods and Materials: A 2-stage genome-wide association study was performed. Patients were split randomly into a stage I discovery cohort (132 cases, 103 controls) and a stage II replication cohort (128 cases, 102 controls). The discovery cohort was genotyped using Affymetrix 6.0 genome-wide arrays. The 940 top ranking SNPs selected from the discovery cohort were genotyped in the replication cohort using Illumina iSelect custom SNP arrays. Results: Twelve SNPs identified in the discovery cohort and validated in the replication cohort were associated with development of ED following radiation therapy (Fisher combined P values 2.1 Multiplication-Sign 10{sup -5} to 6.2 Multiplication-Sign 10{sup -4}). Notably, these 12 SNPs lie in or near genes involved in erectile function or other normal cellular functions (adhesion and signaling) rather than DNA damage repair. In a multivariable model including nongenetic risk factors, the odds ratios for these SNPs ranged from 1.6 to 5.6 in the pooled cohort. There was a striking relationship between the cumulative number of SNP risk alleles an individual possessed and ED status (Sommers' D P value = 1.7 Multiplication-Sign 10{sup -29}). A 1-allele increase in cumulative SNP score increased the odds for developing ED by a factor of 2.2 (P value = 2.1 Multiplication-Sign 10{sup -19}). The cumulative SNP score model had a sensitivity of 84% and specificity of 75% for prediction of developing ED at the radiation therapy planning stage. Conclusions: This genome-wide association study identified a set of SNPs that are associated with development of ED following radiation therapy. These candidate genetic predictors warrant more definitive validation in an independent cohort.

Kerns, Sarah L. [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States) [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, New York (United States); Stock, Richard [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States)] [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); Stone, Nelson [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States) [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); Department of Urology, Mount Sinai School of Medicine, New York, New York (United States); Buckstein, Michael [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States)] [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); Shao, Yongzhao [Division of Biostatistics, New York University School of Medicine, New York, New York (United States)] [Division of Biostatistics, New York University School of Medicine, New York, New York (United States); Campbell, Christopher [Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, New York (United States)] [Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, New York (United States); Rath, Lynda [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States)] [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); De Ruysscher, Dirk; Lammering, Guido [Department of Radiation Oncology, Maastricht University Medical Center, Maastricht (Netherlands)] [Department of Radiation Oncology, Maastricht University Medical Center, Maastricht (Netherlands); Hixson, Rosetta; Cesaretti, Jamie; Terk, Mitchell [Florida Radiation Oncology Group, Jacksonville, Florida (United States)] [Florida Radiation Oncology Group, Jacksonville, Florida (United States); Ostrer, Harry [Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, New York (United States)] [Departments of Pathology and Genetics, Albert Einstein College of Medicine, Bronx, New York (United States); Rosenstein, Barry S., E-mail: barry.rosenstein@mssm.edu [Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York (United States); Department of Radiation Oncology, New York University School of Medicine, New York, New York (United States); Departments of Dermatology and Preventive Medicine, Mount Sinai School of Medicine, New York, New York (United States)

2013-01-01T23:59:59.000Z

236

Can We Distinguish Biological Motions of Virtual Humans? Perceptual Study With Captured Motions of Weight Lifting.  

E-Print Network [OSTI]

Information Systems-- Animations ­ Artificial, augmented, and virtual realities Keywords: Human Motions of Weight Lifting. Ludovic Hoyet IRISA - INRIA Bunraku Team, Rennes Franck Multon Mouvement Sport Sant of Edinburgh Figure 1: Subject lifting a 6kg dumbbell: video of a real motion (up) and corresponding captured

Paris-Sud XI, Université de

237

Radiation detector  

DOE Patents [OSTI]

Apparatus is provided for detecting radiation such as gamma rays and X-rays generated in backscatter Mossbauer effect spectroscopy and X-ray spectrometry, which has a large "window" for detecting radiation emanating over a wide solid angle from a specimen and which generates substantially the same output pulse height for monoenergetic radiation that passes through any portion of the detection chamber. The apparatus includes a substantially toroidal chamber with conductive walls forming a cathode, and a wire anode extending in a circle within the chamber with the anode lying closer to the inner side of the toroid which has the least diameter than to the outer side. The placement of the anode produces an electric field, in a region close to the anode, which has substantially the same gradient in all directions extending radially from the anode, so that the number of avalanche electrons generated by ionizing radiation is independent of the path of the radiation through the chamber.

Fultz, Brent T. (Berkeley, CA)

1983-01-01T23:59:59.000Z

238

Radiation detector  

DOE Patents [OSTI]

Apparatus is provided for detecting radiation such as gamma rays and x-rays generated in backscatter Moessbauer effect spectroscopy and x-ray spectrometry, which has a large window for detecting radiation emanating over a wide solid angle from a specimen and which generates substantially the same output pulse height for monoenergetic radiation that passes through any portion of the detection chamber. The apparatus includes a substantially toroidal chamber with conductive walls forming a cathode, and a wire anode extending in a circle within the chamber with the anode lying closer to the inner side of the toroid which has the least diameter than to the outer side. The placement of the anode produces an electric field, in a region close to the anode, which has substantially the same gradient in all directions extending radially from the anode, so that the number of avalanche electrons generated by ionizing radiation is independent of the path of the radiation through the chamber.

Fultz, B.T.

1980-12-05T23:59:59.000Z

239

Real-time Molecular Study of Bystander Effects of Low dose Low LET radiation Using Living Cell Imaging and Nanoparticale Optics  

SciTech Connect (OSTI)

In this study two novel approaches are proposed to investigate precisely the low dose low LET radiation damage and its effect on bystander cells in real time. First, a flow shear model system, which would provide us a near in vivo situation where endothelial cells in the presence of extra cellular matrix experiencing continuous flow shear stress, will be used. Endothelial cells on matri-gel (simulated extra cellular matrix) will be subjected to physiological flow shear (that occurs in normal blood vessels). Second, a unique tool (Single nano particle/single live cell/single molecule microscopy and spectroscopy; Figure A) will be used to track the molecular trafficking by single live cell imaging. Single molecule chemical microscopy allows one to single out and study rare events that otherwise might be lost in assembled average measurement, and monitor many target single molecules simultaneously in real-time. Multi color single novel metal nanoparticle probes allow one to prepare multicolor probes (Figure B) to monitor many single components (events) simultaneously and perform multi-complex analysis in real-time. These nano-particles resist to photo bleaching and hence serve as probes for unlimited timeframe of analysis. Single live cell microscopy allows one to image many single cells simultaneously in real-time. With the combination of these unique tools, we will be able to study under near-physiological conditions the cellular and sub-cellular responses (even subtle changes at one molecule level) to low and very low doses of low LET radiation in real time (milli-second or nano-second) at sub-10 nanometer spatial resolution. This would allow us to precisely identify, at least in part, the molecular mediators that are responsible of radiation damage in the irradiated cells and the mediators that are responsible for initiating the signaling in the neighboring cells. Endothelial cells subjected to flow shear (2 dynes/cm2 or 16 dynes/cm2) and exposed to 0.1, 1 and 10 cGy on coverslips will be examined for (a) low LET radiation-induced alterations of cellular function and its physiological relevance in real time; and (b) radiation damage triggered bystander effect on the neighboring unirradiated cells. First, to determine the low LET radiation induced alteration of cellular function we will examine: (i) the real time transformation of single membrane transporters in single living cells; (ii) the pump efficiency of membrane efflux pump of live cells in real time at the molecular level; (iii) the kinetics of single-ligand receptor interaction on single live cell surface (Figure C); and (iv) alteration in chromosome replication in living cell. Second, to study the radiation triggered bystander responses, we will examine one of the key signaling pathway i.e. TNF- alpha/NF-kappa B mediated signaling. TNF-alpha specific nano particle sensors (green) will be developed to detect the releasing dynamics, transport mechanisms and ligand-receptor binding on live cell surface in real time. A second sensor (blue) will be developed to simultaneously monitor the track of NF-kB inside the cell. The proposed nano-particle optics approach would complement our DOE funded study on biochemical mechanisms of TNF-alpha- NF-kappa B-mediated bystander effect.

Natarajan, Mohan [UT Health Science Center at San Antonio; Xu, Nancy R [Old Dominion University; Mohan, Sumathy [UT Health Science Center at San Antonio

2013-06-03T23:59:59.000Z

240

Monte Carlo Studies of the Radiation Fields in the Linac Coherent Light Source Undulators and of the Corresponding Signals in the Cerenkov Beam Loss Monitors  

SciTech Connect (OSTI)

In 2009 the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Center started free electron laser (FEL) operation. In order to continue to produce the bright and short-pulsed x-ray laser demanded by FEL scientists, this pioneer hard x-ray FEL requires a perfectly tailored magnetic field at the undulators, so that the photons generated at the electron wiggling path interact at the right phase with the electron beam. In such a precise system, small (>0.01%) radiation-induced alterations of the magnetic field in the permanent magnets could affect FEL performance. This paper describes the simulation studies of radiation fields in permanent magnets and the expected signal in the detectors. The transport of particles from the radiation sources (i.e. diagnostic insert) to the undulator magnets and to the beam loss monitors (BLM) was simulated with the intra nuclear cascade codes FLUKA and MARS15. In order to accurately reproduce the optics of LCLS, lattice capabilities and magnetic fields were enabled in FLUKA and betatron oscillations were validated against reference data. All electron events entering the BLMs were printed in data files. The paper also introduces the Radioactive Ion Beam Optimizer (RIBO) Monte Carlo 3-D code, which was used to read from the event files, to compute Cerenkov production and then to simulate the optical coupling of the BLM detectors, accounting for the transmission of light through the quartz.

Santana Leitner, Mario

2010-09-14T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Stereotactic Body Radiation Therapy Can Be Used Safely to Boost Residual Disease in Locally Advanced Non-Small Cell Lung Cancer: A Prospective Study  

SciTech Connect (OSTI)

Purpose: To report the results of a prospective, single-institution study evaluating the feasibility of conventional chemoradiation (CRT) followed by stereotactic body radiation therapy (SBRT) as a means of dose escalation for patients with stage II-III non-small cell lung cancer (NSCLC) with residual disease. Methods and Materials: Patients without metastatic disease and with radiologic evidence of limited residual disease (?5 cm) within the site of the primary tumor and good or complete nodal responses after standard CRT to a target dose of 60 Gy were considered eligible. The SBRT boost was done to achieve a total combined dose biological equivalent dose >100 Gy to the residual primary tumor, consisting of 10 Gy 2 fractions (20 Gy total) for peripheral tumors, and 6.5 Gy 3 fractions (19.5 Gy total) for medial tumors using the Radiation Therapy Oncology Group protocol 0813 definitions. The primary endpoint was the development of grade ?3 radiation pneumonitis (RP). Results: After a median follow-up of 13 months, 4 patients developed acute grade 3 RP, and 1 (2.9%) developed late and persistent grade 3 RP. No patients developed grade 4 or 5 RP. Mean lung dose, V2.5, V5, V10, and V20 values were calculated for the SBRT boost, and none were found to significantly predict for RP. Only advancing age (P=.0147), previous smoking status (P=.0505), and high CRT mean lung dose (P=.0295) were significantly associated with RP development. At the time of analysis, the actuarial local control rate at the primary tumor site was 82.9%, with only 6 patients demonstrating recurrence. Conclusions: Linear accelerator-based SBRT for dose escalation of limited residual NSCLC after definitive CRT was feasible and did not increase the risk for toxicity above that for standard radiation therapy.

Feddock, Jonathan, E-mail: jmfedd0@uky.edu [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States)] [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States); Arnold, Susanne M. [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States) [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States); Department of Medical Oncology, University of Kentucky, Lexington, Kentucky (United States); Shelton, Brent J. [Department of Biostatistics, University of Kentucky, Lexington, Kentucky (United States)] [Department of Biostatistics, University of Kentucky, Lexington, Kentucky (United States); Sinha, Partha; Conrad, Gary [Department of Radiology, University of Kentucky, Lexington, Kentucky (United States)] [Department of Radiology, University of Kentucky, Lexington, Kentucky (United States); Chen, Li [Department of Biostatistics, University of Kentucky, Lexington, Kentucky (United States)] [Department of Biostatistics, University of Kentucky, Lexington, Kentucky (United States); Rinehart, John [Department of Medical Oncology, University of Kentucky, Lexington, Kentucky (United States)] [Department of Medical Oncology, University of Kentucky, Lexington, Kentucky (United States); McGarry, Ronald C. [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States)] [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky (United States)

2013-04-01T23:59:59.000Z

242

Radiation dosimeter  

DOE Patents [OSTI]

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even though the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, Richard J. (Oak Ridge, TN)

1983-01-01T23:59:59.000Z

243

Radiation dosimeter  

DOE Patents [OSTI]

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even through the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, R.J.

1981-09-01T23:59:59.000Z

244

Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation. Comprehensive progress report, July 1991--June 1994  

SciTech Connect (OSTI)

This comprehensive progress report provides a synopsis of major research accomplishments during the years of 1991-1994, including the technical aspects of the project. The objectives and accomplishments are as follows: 1. Defining the chromosome segments associated with radiation and chemically-induced leukemogenesis (treatment-related acute myeloid leukemia, t-AML); A. Continued genetic analysis of chromosomes 5 and 7, B. Correlation of treatment with balanced and unbalanced translocations. 2. Cloning the breakpoints in balanced translocations in t-AML; A. Clone the t(9;11) and t(11;19) breakpoints, B. Clone the t(3,21)(q26,q22) breakpoint, C. Determine the relationship of these translocations to prior exposure to topoisomerase II inhibitors. 3. Compare the breakpoint junctions in patients who have the same translocations in t-AML and AML de novo. 4. Map the scaffold attachment regions in the genes that are involved in balanced translocations in t-AML. Plans for the continuation of present objectives and possible new objectives in consideration of past results are also provided.

Rowley, J.D.

1994-06-01T23:59:59.000Z

245

RADIATION SAFETY TRAINING MANUAL Radiation Safety Office  

E-Print Network [OSTI]

RADIATION SAFETY TRAINING MANUAL Radiation Safety Office 130 DeSoto Street G-7 Parran with sources of ionizing radiation are required to be instructed in the basic principles of radiation protection and the potential risks of ionizing radiation. Radiation Safety Office personnel provide

Sibille, Etienne

246

Mesenchymal Stem Cells Retain Their Defining Stem Cell Characteristics After Exposure to Ionizing Radiation  

SciTech Connect (OSTI)

Purpose: Mesenchymal stem cells (MSCs) have the ability to migrate to lesion sites and undergo differentiation into functional tissues. Although this function may be important for tissue regeneration after radiation therapy, the influence of ionizing radiation (IR) on cellular survival and the functional aspects of differentiation and stem cell characteristics of MSCs have remained largely unknown. Methods and Materials: Radiation sensitivity of human primary MSCs from healthy volunteers and primary human fibroblast cells was examined, and cellular morphology, cell cycle effects, apoptosis, and differentiation potential after exposure to IR were assessed. Stem cell gene expression patterns after exposure to IR were studied using gene arrays. Results: MSCs were not more radiosensitive than human primary fibroblasts, whereas there were considerable differences regarding radiation sensitivity within individual MSCs. Cellular morphology, cytoskeletal architecture, and cell motility were not markedly altered by IR. Even after high radiation doses up to 10 Gy, MSCs maintained their differentiation potential. Compared to primary fibroblast cells, MSCs did not show an increase in irradiation-induced apoptosis. Gene expression analyses revealed an upregulation of various genes involved in DNA damage response and DNA repair, but expression of established MSC surface markers appeared only marginally influenced by IR. Conclusions: These data suggest that human MSCs are not more radiosensitive than differentiated primary fibroblasts. In addition, upon photon irradiation, MSCs were able to retain their defining stem cell characteristics both on a functional level and regarding stem cell marker expression.

Nicolay, Nils H., E-mail: n.nicolay@dkfz.de [Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg (Germany); Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Sommer, Eva; Lopez, Ramon; Wirkner, Ute [Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Trinh, Thuy [Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg (Germany); Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Sisombath, Sonevisay [Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Debus, Jrgen [Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg (Germany); Ho, Anthony D.; Saffrich, Rainer [Department of Hematology and Oncology, Heidelberg University Hospital, Heidelberg (Germany); Huber, Peter E. [Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg (Germany); Department of Molecular and Radiation Oncology, German Cancer Research Center, Heidelberg (Germany)

2013-12-01T23:59:59.000Z

247

Structural and Functional Studies on Human Mitochondrial Iron-Sulfur Cluster Biosynthesis  

E-Print Network [OSTI]

. (2003) Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry. Curr. Opin. Chem. Biol. 7, 166-173]. 3 as the nitrogen-fixation (NIF) machinery (8). The NIF pathway is often a specialized assembly system... of Fe?S Cluster Biogenesis in Human Mitochondria Name Essential in yeast Yeast homologs Bacterial homologs Proposed function & protein interactions Nfs1 Yes Nfs1 IscS, NifS, SufS Cysteine desulfurase, sulfur donor, Interacts with Isd11, Isu2...

Tsai, Chi-Lin

2012-07-16T23:59:59.000Z

248

Thus mangle ye still the human race: a study in structural navigation  

E-Print Network [OSTI]

that individuality is socially constructed so we are, in a sense, predetermined by the societies we are 3 raised in; however, that determinacy does not preclude any agency and once we have become self aware, we are capable of making changes within the bounds... one another at a first glance?? (Ibid., 88-89). Unlike T?nnies, Durkheim does not have a long story to explain the existence of the division of labor; he argues it has always existed, in one form or another, in human societies; in mechanical...

Harden, B. Garrick

2006-08-16T23:59:59.000Z

249

(Radiation carcinogenesis in the whole body system)  

SciTech Connect (OSTI)

The objectives of the trip were: to take part in and to give the summary of a Symposium on Radiation Carcinogenesis at Tokyo, and to give a talk at the National Institute of Radiological Sciences at Chiba. The breadth of the aspects considered at the conference was about as broad as is possible, from effects at the molecular level to human epidemiology, from the effects of tritium to cancer induction by heavy ions. The events induced by cancer that lead to cancer and the events that are secondary are beginning to come into better focus but much is still not known. Interest in suppressor genes is increasing rapidly in the studies of human tumors and many would predict that the three or four suppressor genes associated with cancer are only the first sighting of a much larger number.

Fry, R.J.M.

1990-12-14T23:59:59.000Z

250

Influence of Extraterrestrial Radiation on Radiation Portal Monitors  

SciTech Connect (OSTI)

Cosmic radiation and solar flares can be a major source of background radiation at the Earths surface. This paper examines the relationship between extraterrestrial radiation and the detectable background in radiation portal monitors used for homeland security applications. Background radiation data from 13 radiation portal monitor facilities are examined and compared against external sources of data related to extraterrestrial radiation, including measurements at neutron monitors located at 53 cosmic-ray observatories around the Earth, four polar orbiting satellites, three geostationary satellites, ground-based geomagnetic field data from observatories around the Earth, a solar magnetic index, solar radio flux data, and sunspot activity data. Four-years (January 2003 through December 2006) of data are used in this study, which include the latter part of Solar Cycle 23 as solar activity was on the decline. The analysis shows a significant relationship between some extraterrestrial radiation and the background detected in the radiation portal monitors. A demonstrable decline is shown in the average gamma ray and neutron background at the radiation portal monitors as solar activity declined over the period of the study.

Keller, Paul E.; Kouzes, Richard T.

2009-06-01T23:59:59.000Z

251

Five-year Local Control in a Phase II Study of Hypofractionated Intensity Modulated Radiation Therapy With an Incorporated Boost for Early Stage Breast Cancer  

SciTech Connect (OSTI)

Purpose: Conventional radiation fractionation of 1.8-2 Gy per day for early stage breast cancer requires daily treatment for 6-7 weeks. We report the 5-year results of a phase II study of intensity modulated radiation therapy (IMRT), hypofractionation, and incorporated boost that shortened treatment time to 4 weeks. Methods and Materials: The study design was phase II with a planned accrual of 75 patients. Eligibility included patients aged {>=}18 years, Tis-T2, stage 0-II, and breast conservation. Photon IMRT and an incorporated boost was used, and the whole breast received 2.25 Gy per fraction for a total of 45 Gy, and the tumor bed received 2.8 Gy per fraction for a total of 56 Gy in 20 treatments over 4 weeks. Patients were followed every 6 months for 5 years. Results: Seventy-five patients were treated from December 2003 to November 2005. The median follow-up was 69 months. Median age was 52 years (range, 31-81). Median tumor size was 1.4 cm (range, 0.1-3.5). Eighty percent of tumors were node negative; 93% of patients had negative margins, and 7% of patients had close (>0 and <2 mm) margins; 76% of cancers were invasive ductal type: 15% were ductal carcinoma in situ, 5% were lobular, and 4% were other histology types. Twenty-nine percent of patients 29% had grade 3 carcinoma, and 20% of patients had extensive in situ carcinoma; 11% of patients received chemotherapy, 36% received endocrine therapy, 33% received both, and 20% received neither. There were 3 instances of local recurrence for a 5-year actuarial rate of 2.7%. Conclusions: This 4-week course of hypofractionated radiation with incorporated boost was associated with excellent local control, comparable to historical results of 6-7 weeks of conventional whole-breast fractionation with sequential boost.

Freedman, Gary M., E-mail: Gary.Freedman@uphs.upenn.edu [Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Anderson, Penny R. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Bleicher, Richard J. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Litwin, Samuel; Li Tianyu [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Swaby, Ramona F. [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Ma, Chang-Ming Charlie; Li Jinsheng [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Sigurdson, Elin R. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Watkins-Bruner, Deborah [School of Nursing, Emory University, Atlanta, Georgia (United States)] [School of Nursing, Emory University, Atlanta, Georgia (United States); Morrow, Monica [Department of Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Goldstein, Lori J. [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)] [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)

2012-11-15T23:59:59.000Z

252

When is More Data Valuable to Human Operators? The Cognitive Engineering Laboratory (CEL) plans to conduct a microworld simulator study during the summer of 2014.  

E-Print Network [OSTI]

When is More Data Valuable to Human Operators? The Cognitive Engineering Laboratory (CEL) plans to conduct a microworld simulator study during the summer of 2014. The objective is to evaluate human only looked at operator performance under normal operating conditions. Will having additional sensor

253

Radiation receiver  

DOE Patents [OSTI]

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

Hunt, A.J.

1983-09-13T23:59:59.000Z

254

Radiation receiver  

DOE Patents [OSTI]

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

Hunt, Arlon J. (Oakland, CA)

1983-01-01T23:59:59.000Z

255

Triple ion-beam studies of radiation damage in 9Cr2WVTa ferritic/martensitic steel  

SciTech Connect (OSTI)

To simulate radiation damage under a future Spallation Neutron Source (SNS) environment, irradiation experiments were conducted on a candidate 9Cr-2WVTa ferritic/martensitic steel using the Triple Ion Facility (TIF) at ORNL. Irradiation was conducted in single, dual, and triple ion beam modes using 3.5 MeV Fe{sup ++}, 360 keV He{sup +}, and 180 keV H{sup +} at 80, 200, and 350{degrees}C. These irradiations produced various defects comprising black dots, dislocation loops, line dislocations, and gas bubbles, which led to hardening. The largest increase in hardness, over 63 %, was observed after 50 dpa for triple beam irradiation conditions, revealing that both He and H are augmenting the hardening. Hardness increased less than 30 % after 30 dpa at 200{degrees}C by triple beams, compatible with neutron irradiation data from previous work which showed about a 30 % increase in yield strength after 27.2 dpa at 365{degrees}C. However, the very large concentrations of gas bubbles in the matrix and on lath and grain boundaries after these simulated SNS irradiations make predictions of fracture behavior from fission reactor irradiations to spallation target conditions inadvisable.

Lee, E.H.; Hunn, J.D.; Rao, G.R.; Klueh, R.L.; Mansur, L.K.

1997-11-01T23:59:59.000Z

256

Effects of p60 sCo gamma radiation on Sarcina lutea: A comparison of effects at two different exposure rates and a study of the radiosensitizing properties of prodigiosin.  

E-Print Network [OSTI]

of pigmented and nonpigmented cells. Radiation Res. 48, 40-52 (1971). 8. R. P. Williams, Biosynthesis of Prodigiosin, a Secondary Metabolite of Serratia marcescens, ~A 1. Microbiol. 25, 396-402 (1973). 9. M. M. Matthews, and N. I. Krinsky, The relatioship... Radiation on Sarcina ]utes: A Comparison of Effects at Two Different Exposure Rates and A Study of the Radiosensitizing Properties of. Prodigiosin (August 1973) George W. Blair, Jr. , B. S, , University of Chattanooga Directed by: Dr. R. D. Neff...

Blair, George Washington

1973-01-01T23:59:59.000Z

257

Radiation Damage in Nanostructured Metallic Films  

E-Print Network [OSTI]

with favorable microstructures and to investigate their response to radiation. The goals of this thesis are to study the radiation responses of several nanostructured metallic thin film systems, including Ag/Ni multilayers, nanotwinned Ag and nanocrystalline Fe...

Yu, Kaiyuan

2013-04-15T23:59:59.000Z

258

NEW SOURCES OF RADIATION  

E-Print Network [OSTI]

Stanford Synchrotron Radiation Project Report No. 75/07.IBL 79M0733 Fig. 20. Radiation emission pattern by electronsWinick, Stanford Synchrotron Radiation Laboratory. Fig. 21.

Schimmerling, W.

2010-01-01T23:59:59.000Z

259

Radiation-induced angiosarcoma  

E-Print Network [OSTI]

1a Figure 1b Figure 1. Radiation-induced angiosarcoma in afollowing completion of radiation therapy. Figure 2a Figurecell histiocytosis after radiation for breast carcinoma: can

Anzalone, C Lane; Cohen, Philip R; Diwan, Abdul H; Prieto, Victor G

2013-01-01T23:59:59.000Z

260

Radiation Protection Act (Pennsylvania)  

Broader source: Energy.gov [DOE]

This Act combines the radiation safety provisions of The Atomic Energy Development and Radiation Control Act and the Environmental Radiation Protection Act, and empowers the Department of...

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Office of Domestic and International Health Studies  

Broader source: Energy.gov [DOE]

The Office of Domestic and International Health Studies engages in the conduct of international scientific studies that may provide new knowledge and information about the human response to ionizing radiation in the workplace or people exposed in communities as a result of nuclear accidents, including providing health and environmental monitoring services to populations specified by law.

262

A Study to Increase Participation of Habitat for Humanity Affiliates in LEED for Homes Certification  

E-Print Network [OSTI]

affiliates across the United States, and the other five scorecards came from a production home builder in Texas. The scorecards were then compared by determining the mean of points for each question. From this case study, the survey shows cost and knowledge...

Rabb, Amy Elizabeth

2013-04-30T23:59:59.000Z

263

SNP in TXNRD2 Associated With Radiation-Induced Fibrosis: A Study of Genetic Variation in Reactive Oxygen Species Metabolism and Signaling  

SciTech Connect (OSTI)

Purpose: The aim of the study was to identify noninvasive markers of treatment-induced side effects. Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs). Methods and Materials: 92 breast cancer (BC) survivors previously treated with hypofractionated radiation therapy were assessed for the AEs subcutaneous atrophy and fibrosis, costal fractures, lung fibrosis, pleural thickening, and telangiectasias (median follow-up time 17.1 years). Single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed for association to AE grade. SNPs associated with subcutaneous fibrosis were validated in an independent BC survivor material (n=283). The influence of the studied genetic variation on messenger ribonucleic acid (mRNA) expression level of 18 genes previously associated with fibrosis was assessed in fibroblast cell lines from BC patients. Results: Subcutaneous fibrosis and atrophy had the highest correlation (r=0.76) of all assessed AEs. The nonsynonymous SNP rs1139793 in TXNRD2 was associated with grade of subcutaneous fibrosis, the reference T-allele being more prevalent in the group experiencing severe levels of fibrosis. This was confirmed in another sample cohort of 283 BC survivors, and rs1139793 was found significantly associated with mRNA expression level of TXNRD2 in blood. Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P?.005). Conclusion: Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance.

Edvardsen, Hege, E-mail: hege.edvardsen@rr-research.no [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Landmark-Hyvik, Hege [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Reinertsen, Kristin V. [National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway)] [National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway); Zhao, Xi [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Grenaker-Alns, Grethe Irene; Nebdal, Daniel [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway)] [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); Syvnen, Ann-Christine [Department of Medical Sciences, Uppsala University, Uppsala (Sweden)] [Department of Medical Sciences, Uppsala University, Uppsala (Sweden); Rdningen, Olaug [Department of Medical Genetics, OUS Ullevaal, Oslo (Norway)] [Department of Medical Genetics, OUS Ullevaal, Oslo (Norway); Alsner, Jan; Overgaard, Jens [Department of Experimental Clinical Oncology, Ahus University Hospital (Norway)] [Department of Experimental Clinical Oncology, Ahus University Hospital (Norway); Borresen-Dale, Anne-Lise [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Foss, Sophie D. [K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway) [K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway); Kristensen, Vessela N. [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Ahus University Hospital (Norway)

2013-07-15T23:59:59.000Z

264

Travel for the 2004 American Statistical Association Biannual Radiation Meeting: "Radiation in Realistic Environments: Interactions Between Radiation and Other Factors  

SciTech Connect (OSTI)

The 16th ASA Conference on Radiation and Health, held June 27-30, 2004 in Beaver Creek, CO, offered a unique forum for discussing research related to the effects of radiation exposures on human health in a multidisciplinary setting. The Conference furnishes investigators in health related disciplines the opportunity to learn about new quantitative approaches to their problems and furnishes statisticians the opportunity to learn about new applications for their discipline. The Conference was attended by about 60 scientists including statisticians, epidemiologists, biologists and physicists interested in radiation research. For the first time, ten recipients of Young Investigator Awards participated in the conference. The Conference began with a debate on the question: Do radiation doses below 1 cGy increase cancer risks? The keynote speaker was Dr. Martin Lavin, who gave a banquet presentation on the timely topic How important is ATM? The focus of the 2004 Conference on Radiation and Health was Radiation in Realistic Environments: Interactions Between Radiation and Other Risk Modifiers. The sessions of the conference included: Radiation, Smoking, and Lung Cancer Interactions of Radiation with Genetic Factors: ATM Radiation, Genetics, and Epigenetics Radiotherapeutic Interactions The Conference on Radiation and Health is held bi-annually, and participants are looking forward to the 17th conference to be held in 2006.

Brenner, David J.

2009-07-21T23:59:59.000Z

265

Cognitive Science (Humanities)  

E-Print Network [OSTI]

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

266

PPPL3301, Preprint: May 1998, UC426 Design Study of a Visible/Infrared Periscope for Intense Radiation  

E-Print Network [OSTI]

PPPL­3301, Preprint: May 1998, UC­426 Design Study of a Visible/Infrared Periscope for Intense projected heating of the reflective optics themselves to several hundred degrees Celsius. Tests of beryllium regions during operation and infrared measurement of the surface temperature of the first wall structures

267

PPPL-3301, Preprint: May 1998, UC-426 Design Study of a Visible/Infrared Periscope for Intense Radiation  

E-Print Network [OSTI]

PPPL-3301, Preprint: May 1998, UC-426 Design Study of a Visible/Infrared Periscope for Intense projected heating of the reflective optics themselves to several hundred degrees Celsius. Tests of beryllium regions during operation and infrared measurement of the surface temperature of the first wall structures

268

Laser fluorescence study of AIO formed in the reaction AI + O2: Product state distribution, dissociation energy, and radiative  

E-Print Network [OSTI]

+ 0 has been studied by Fontijn, Felder, and Houghton! in a fast- flow reactor. They find are reported for AIO products formed under single-collision conditions in a "beam-gas" arrangement the combustion of metals has long been a fruitful topic in chemical research, the gas-phase oxida- tion process M

Zare, Richard N.

269

Environmental effects on composite airframes: A study conducted for the ARM UAV Program (Atmospheric Radiation Measurement Unmanned Aerospace Vehicle)  

SciTech Connect (OSTI)

Composite materials are affected by environments differently than conventional airframe structural materials are. This study identifies the environmental conditions which the composite-airframe ARM UAV may encounter, and discusses the potential degradation processes composite materials may undergo when subjected to those environments. This information is intended to be useful in a follow-on program to develop equipment and procedures to prevent, detect, or otherwise mitigate significant degradation with the ultimate goal of preventing catastrophic aircraft failure.

Noguchi, R.A.

1994-06-01T23:59:59.000Z

270

Study the cytotoxicity of different kinds of water-soluble nanoparticles in human osteoblast-like MG-63 cells  

SciTech Connect (OSTI)

Highlights: ? Preparation of three kinds of water-soluble QDs: CdTe, CdTe@SiO{sub 2}, Mn:ZnSe. ? Evaluated the cytotoxicity qualitatively and quantitatively. ? Fluorescent staining. ? Detected the total intracellular cadmium in cells. -- Abstract: Quantum nanoparticles have been applied extensively in biological and medical fields, the cytotoxicity of nanoparticles becomes the key point we should concern. In this paper, the cytotoxicity of three kinds of water-soluble nanoparticles: CdTe, CdTe@SiO{sub 2} and Mn:ZnSe was studied. We evaluated the nanoparticles toxicity qualitatively by observing the morphological changes of human osteoblast-like MG-63 cells at different incubation times and colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays were carried out to detect the cell viability quantitatively. The results showed that CdTe nanoparticles with high concentrations caused cells to die largely while CdTe@SiO{sub 2} and Mn:ZnSe nanoparticles had no obvious effect. For further study, we studied the relation between the cell viability and the total cadmium concentration in cells and found that the viability of cells treated with CdTe@SiO{sub 2} nanoparticles was higher than that treated with CdTe nanoparticles. We also discovered that the death rate of cells co-incubated with CdTe nanoparticles was proportional to the total intracellular cadmium concentrations.

Niu, Lu [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)] [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Li, Yang; Li, Xiaojie [Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Centre, Norman Bethune Medical School, Jilin University, Changchun 130012 (China)] [Department of Pathophysiology, Prostate Diseases Prevention and Treatment Research Centre, Norman Bethune Medical School, Jilin University, Changchun 130012 (China); Gao, Xue [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)] [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Su, Xingguang, E-mail: suxg@jlu.edu.cn [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)] [Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)

2012-11-15T23:59:59.000Z

271

Temperature Measurement During Polymerization of Bone Cement in Percutaneous Vertebroplasty: An In Vivo Study in Humans  

SciTech Connect (OSTI)

Aim of the study was to 'in vivo' measure temperature, during percutaneous vertebroplasty (PV), within a vertebral body injected with different bone cements. According to the declaration of Helsinki, 22 women (60-80 years; mean, 75 years) with painful osteoporotic vertebral collapse underwent bilateral transpedicular PV on 22 lumbar vertebrae. Two 10-G vertebroplasty needles were introduced into the vertebra under digital fluoroscopy; a 16-G radiofrequency thermoablation needle (Starburst XL; RITA Medical System Inc., USA), carrying five thermocouples, was than coaxially inserted. Eleven different bone cements were injected and temperatures were measured every 30 s until temperatures dropped under 45{sup o}C. After the thermocouple needle was withdrawn, bilateral PV was completed with cement injection through the vertebroplasty needle. Unpaired Student's t-tests, Kruskal-Wallis test, and Wilcoxon signed rank test were used to evaluate significant differences (p < 0.05) in peak temperatures, variations between cements, and clinical outcome. All procedures were completed without complications, achieving good clinical outcomes (p < 0.0001). Regarding average peak temperature, cements were divided into three groups: A (over 60{sup o}C), B (from 50{sup o} to 60{sup o}C), and C (below 50{sup o}C). Peak temperature in Group A (86.7 {+-} 10.7{sup o}C) was significantly higher (p = 0.0172) than that in Groups B (60.5 {+-} 3.7{sup o}C) and C (44.8 {+-} 2.6{sup o}C). The average of all thermocouples showed an extremely significant difference (p = 0.0002) between groups. None of the tested cements maintained a temperature {>=}45{sup o}C for more than 30 min. These data suggest that back-pain improvement is obtained not by thermal necrosis but by mechanical consolidation only. The relative necrotic thermal effect in vertebral metastases seems to confirm that analgesia must be considered the main intent of PV.

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it; Manca, Antonio [Institute for Cancer Research and Treatment (IRCC), Interventional Radiology Unit (Italy); Kanika, Khanna; Murphy, Kieran [Johns Hopkins Hospital, Radiology and Radiological Science (United States); Eminefendic, Haris [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy); Masala, Salvatore ['Tor Vergata' University General Hospital, Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy (Italy); Regge, Daniele [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy)

2009-05-15T23:59:59.000Z

272

Alpha Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout theOFFICE OF RESEARCHThermal SolarAllocatioBasics of Radiation Gamma

273

Radiation Transport Simulation Studies Using MCNP for a Cow Phantom to Determine an Optimal Detector Configuration for a New Livestock Portal  

E-Print Network [OSTI]

scalable gamma radiation portal monitor (RPM) which can be used to assess the level of contamination on large animals like cattle. This work employed a Monte Carlo N-Particle (MCNP) radiation transport code for the purpose. A virtual system of cow...

Joe Justina, -

2012-10-19T23:59:59.000Z

274

Abdominal radiation causes bacterial translocation  

SciTech Connect (OSTI)

The purpose of this study was to determine if a single dose of radiation to the rat abdomen leads to bacterial translocation into the mesenteric lymph nodes (MLN). A second issue addressed was whether translocation correlates with anatomic damage to the mucosa. The radiated group (1100 cGy) which received anesthesia also was compared with a control group and a third group which received anesthesia alone but no abdominal radiation. Abdominal radiation lead to 100% positive cultures of MLN between 12 hr and 4 days postradiation. Bacterial translocation was almost nonexistent in the control and anesthesia group. Signs of inflammation and ulceration of the intestinal mucosa were not seen until Day 3 postradiation. Mucosal damage was maximal by Day 4. Bacterial translocation onto the MLN after a single dose of abdominal radiation was not apparently dependent on anatomical, histologic damage of the mucosa.

Guzman-Stein, G.; Bonsack, M.; Liberty, J.; Delaney, J.P.

1989-02-01T23:59:59.000Z

275

Study of electron acceleration and x-ray radiation as a function of plasma density in capillary-guided laser wakefield accelerators  

SciTech Connect (OSTI)

Laser wakefield electron acceleration in the blow-out regime and the associated betatron X-ray radiation were investigated experimentally as a function of the plasma density in a configuration where the laser is guided. Dielectric capillary tubes were employed to assist the laser keeping self-focused over a long distance by collecting the laser energy around its central focal spot. With a 40 fs, 16 TW pulsed laser, electron bunches with tens of pC charge were measured to be accelerated to an energy up to 300 MeV, accompanied by X-ray emission with a peak brightness of the order of 10{sup 21} ph/s/mm{sup 2}/mrad{sup 2}/0.1%BW. Electron trapping and acceleration were studied using the emitted X-ray beam distribution to map the acceleration process; the number of betatron oscillations performed by the electrons was inferred from the correlation between measured X-ray fluence and beam charge. A study of the stability of electron and X-ray generation suggests that the fluctuation of X-ray emission can be reduced by stabilizing the beam charge. The experimental results are in good agreement with 3D particle-in-cell (PIC) simulation.

Ju, J.; Dpp, A.; Cros, B. [Laboratoire de Physique des Gaz et des Plasmas, CNRS-Universit Paris-Sud, 91405 Orsay (France)] [Laboratoire de Physique des Gaz et des Plasmas, CNRS-Universit Paris-Sud, 91405 Orsay (France); Svensson, K.; Genoud, G.; Wojda, F.; Burza, M.; Persson, A.; Lundh, O.; Wahlstrm, C.-G. [Department of Physics, Lund University, P.O. Box 118, S-22100 Lund (Sweden)] [Department of Physics, Lund University, P.O. Box 118, S-22100 Lund (Sweden); Ferrari, H. [Consejo Nacional de Investigaciones Cientficas y Tcnicas (CONICET) and CNEA-CAB (Argentina)] [Consejo Nacional de Investigaciones Cientficas y Tcnicas (CONICET) and CNEA-CAB (Argentina)

2013-08-15T23:59:59.000Z

276

Studies on the binding of 5-N-methylated quindoline derivative to human telomeric G-quadruplex  

SciTech Connect (OSTI)

Research highlights: {yields} Hydrophobic interaction provided an important driving force for the interaction between ligand and G-quadruplex. {yields} Constrained water molecules were released from surface of G-tetrad upon the formation of the complex. {yields} The end-stacking mode for quindoline derivative was validated through UV-vis, ITC, steady-state, and time-resolved fluorescence experiment. {yields} The binding of compound 1 to quadruplex was found to be a temperature-dependent and enthalpy-entropy compensation process. -- Abstract: Quindoline derivatives as telomeric quadruplex ligands have shown good biological activity for telomerase inhibition. In the present study, we used spectroscopic and calorimetric methods to investigate the interactions between a quindoline derivative (5-methyl-11-(2-morpholinoethylamino)-10-H-indolo-[3,2-b]quinolin-5-ium iodide, compound 1) and human telomeric G-quadruplex. The thermodynamic studies using isothermal titration calorimetry (ITC) indicated that their binding process was temperature-dependent and enthalpy-entropy co-driven. The significant negative heat capacity was obtained experimentally from the temperature dependence of enthalpy changes, which was consistent with that from theoretical calculation, and all suggesting significant hydrophobic contribution to the molecular recognition process. Based on the results from UV-vis, ITC, steady-state and time-resolved fluorescence, their binding mode was determined as two ligand molecules stacking on the quartets on both ends of the quadruplex. These results shed light on rational design and development of quindoline derivatives as G-quadruplex binding ligands.

Xu, Wei; Tan, Jia-Heng; Chen, Shuo-Bin; Hou, Jin-Qiang; Li, Ding [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)] [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China); Huang, Zhi-Shu, E-mail: ceshzs@mail.sysu.edu.cn [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)] [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China); Gu, Lian-Quan, E-mail: cesglq@mail.sysu.edu.cn [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)] [School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006 (China)

2011-03-18T23:59:59.000Z

277

Studies of acute and chronic radiation injury at the Biological and Medical Research Division, Argonne National Laboratory, 1970-1992: The JANUS Program Survival and Pathology Data  

SciTech Connect (OSTI)

A research reactor for exclusive use in experimental radiobiology was designed and built at Argonne National Laboratory in the 1960`s. It was located in a special addition to Building 202, which housed the Division of Biological and Medical Research. Its location assured easy access for all users to the animal facilities, and it was also near the existing gamma-irradiation facilities. The water-cooled, heterogeneous 200-kW(th) reactor, named JANUS, became the focal point for a range of radiobiological studies gathered under the rubic of {open_quotes}the JANUS program{close_quotes}. The program ran from about 1969 to 1992 and included research at all levels of biological organization, from subcellular to organism. More than a dozen moderate- to large-scale studies with the B6CF{sub 1} mouse were carried out; these focused on the late effects of whole-body exposure to gamma rays or fission neutrons, in matching exposure regimes. In broad terms, these studies collected data on survival and on the pathology observed at death. A deliberate effort was made to establish the cause of death. This archieve describes these late-effects studies and their general findings. The database includes exposure parameters, time of death, and the gross pathology and histopathology in codified form. A series of appendices describes all pathology procedures and codes, treatment or irradiation codes, and the manner in which the data can be accessed in the ORACLE database management system. A series of tables also presents summaries of the individual experiments in terms of radiation quality, sample sizes at entry, mean survival times by sex, and number of gross pathology and histopathology records.

Grahn, D.; Wright, B.J.; Carnes, B.A.; Williamson, F.S.; Fox, C.

1995-02-01T23:59:59.000Z

278

Appendix E. Radiation Oak Ridge Reservation Annual Site Environmental Report--2012  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix E. Radiation #12;#12;Oak Ridge Reservation Annual Site Environmental Report--2012 Appendix

Pennycook, Steve

279

Appendix E. Radiation Oak Ridge Reservation Annual Site Environmental Report--2013  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix E. Radiation #12;#12;Oak Ridge Reservation Annual Site Environmental Report--2013 Appendix

Pennycook, Steve

280

Sorafenib Enhances Radiation-Induced Apoptosis in Hepatocellular Carcinoma by Inhibiting STAT3  

SciTech Connect (OSTI)

Purpose: Hepatocellular carcinoma (HCC) is one of the most common and lethal human malignancies. Lack of efficient therapy for advanced HCC is a pressing problem worldwide. This study aimed to determine the efficacy and mechanism of combined sorafenib and radiation therapy treatment for HCC. Methods and Materials: HCC cell lines (PLC5, Huh-7, Sk-Hep1, and Hep3B) were treated with sorafenib, radiation, or both, and apoptosis and signal transduction were analyzed. Results: All 4 HCC cell lines showed resistance to radiation-induced apoptosis; however, this resistance could be reversed in the presence of sorafenib. Inhibition of phospho-STAT3 was found in cells treated with sorafenib or sorafenib plus radiation and subsequently reduced the expression levels of STAT3-related proteins, Mcl-1, cyclin D1, and survivin. Silencing STAT3 by RNA interference overcame apoptotic resistance to radiation in HCC cells, and the ectopic expression of STAT3 in HCC cells abolished the radiosensitizing effect of sorafenib. Moreover, sorafenib plus radiation significantly suppressed PLC5 xenograft tumor growth. Conclusions: These results indicate that sorafenib sensitizes resistant HCC cells to radiation-induced apoptosis via downregulating phosphorylation of STAT3 in vitro and in vivo.

Huang, Chao-Yuan [Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China) [Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan (China); Lin, Chen-Si [School of Veterinary Medicine, National Taiwan University Hospital, Taipei, Taiwan (China)] [School of Veterinary Medicine, National Taiwan University Hospital, Taipei, Taiwan (China); Tai, Wei-Tien; Hsieh, Chi-Ying [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China) [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China); National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan (China); Shiau, Chung-Wai [Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (China)] [Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (China); Cheng, Ann-Lii [Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China) [Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan (China); Chen, Kuen-Feng, E-mail: kfchen1970@ntu.edu.tw [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China) [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China); National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan (China)

2013-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Assessing exposure to radiation  

SciTech Connect (OSTI)

Since the founding of Lawrence Livermore National Laboratory, we have been world leaders in evaluating the risks associated with radiation. Ultrasensitive tools allow us not only to measure radionuclides present in the body but also to reconstruct the radiation dose from past nuclear events and to project the levels of radiation that will still be present in the body for 50 years after the initial intake. A variety of laboratory procedures, including some developed here, give us detailed information on the effects of radiation at the cellular level. Even today, we are re-evaluating the neutron dose resulting from the bombing at Hiroshima. Our dose reconstruction and projection capabilities have also been applied to studies of Nagasaki, Chernobyl, the Mayak industrial complex in the former Soviet Union, the Nevada Test Site, Bikini Atoll, and other sites. We are evaluating the information being collected on individuals currently working with radioactive material at Livermore and elsewhere as well as previously collected data on workers that extends back to the Manhattan Project.

Walter, K.

1997-01-01T23:59:59.000Z

282

Adaptors for radiation detectors  

DOE Patents [OSTI]

Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

Livesay, Ronald Jason

2014-04-22T23:59:59.000Z

283

POSTDOCTORAL FELLOWSHIP: DIGITAL HUMANITIES AND NEW MEDIA The Institute for Women's and Gender Studies (IWGS) at the University of  

E-Print Network [OSTI]

POSTDOCTORAL FELLOWSHIP: DIGITAL HUMANITIES AND NEW MEDIA The Institute for Women's and Gender in Digital Humanities and New Media starting as soon as possible, and lasting up to two years. The successful Postdoctoral Fellow will consult and collaborate with faculty members on digital and new media projects. S

Martin, Jeff

284

Purely radiative perfect fluids  

E-Print Network [OSTI]

We study `purely radiative' (div E = div H = 0) and geodesic perfect fluids with non-constant pressure and show that the Bianchi class A perfect fluids can be uniquely characterized --modulo the class of purely electric and (pseudo-)spherically symmetric universes-- as those models for which the magnetic and electric part of the Weyl tensor and the shear are simultaneously diagonalizable. For the case of constant pressure the same conclusion holds provided one also assumes that the fluid is irrotational.

B. Bastiaensen; H. R. Karimian; N. Van den Bergh; L. Wylleman

2007-05-08T23:59:59.000Z

285

High-Pressure Synchtron Radiation X-Ray Diffraction Studies of Pentaerythritol Tetranitrate C(CH[subscript 2]ONO[subscript 2 ])[subscript 4  

SciTech Connect (OSTI)

A high-pressure x-ray diffraction study of nanocrystalline pentaerythritol tetranitrate, C(CH{sub 2}ONO{sub 2}){sub 4}, (PETN), has been performed in a diamond-anvil cell at ambient temperature using synchrotron radiation. Pressure-induced alterations in the profiles of the diffraction lines, including their positions, widths and intensities were followed up to 30 GPa in a compressino cycle. The spectral changes in the diffraction patterns at low pressures indicated continuous densification of the tetragonal structure (space group P{bar 4}2{sub 1}c). The diffraction patterns confirmed that PETN compressed from ambient pressure to 7.4 GPa by 17%. At 8.2 GPa and above, several new diffraction lines appeared in the patterns. These lines suggest that the lattice undergoes an incomplete stress-induced structural transformation from the tetragonal to an orthorhombic structure (most probably space group P2{sub 1}22{sub 1}). The mixture of both structures appeared to persist to 30 GPa. The progressive broadening of the diffraction lines as the pressure increased beyond 10 GPa is attributed to the combined diffraction lines of a mixture of two coexisting PETN phases and inhomogeneous pressure distribution within the sample.

Lipinska-Kalita, K.E.; Pravica, M.; Nicol, M. (UNLV)

2006-02-02T23:59:59.000Z

286

Three-dimensional, two-species magnetohydrodynamic studies of the early time behaviors of the Combined Release and Radiation Effects Satellite G2 barium release  

SciTech Connect (OSTI)

We present a three-dimensional, two-species (Ba{sup +} and H{sup +}) MHD model to study the early time behaviors of a barium release at about 1 R{sub E} like Combined Release and Radiation Effects Satellite G2, with emphasis placed on the three-dimensional evolution of the barium cloud and its effects on the ambient plasma environment. We find that the perturbations caused by the cloud are the combined results of the initial injection, the radial expansion, and the diamagnetic effect and propagate as fast MHD waves in the magnetosphere. In return, the transverse expansion and the cross-B motion of barium ions are constrained by the magnetic force, which lead to a field-aligned striation of ions and the decoupling of these ions from the neutrals. Our simulation shows the formation and collapse of the diamagnetic cavity in the barium cloud. The estimated time scale for the cavity evolution might be much shorter if photoionization time scale and field aligned expansion of barium ions are considered. In addition, our two species MHD simulation also finds the snowplow effect resulting from the momentum coupling between barium ions and background H{sup +}, which creates density hole and bumps in the background H{sup +} when barium ions expanding along the magnetic field lines.

Xie, Lianghai, E-mail: xielh@nssc.ac.cn; Li, Lei; Wang, Jingdong; Zhang, Yiteng [Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190 (China)] [Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190 (China)

2014-04-15T23:59:59.000Z

287

A dosimetric comparative study: Volumetric modulated arc therapy vs intensity-modulated radiation therapy in the treatment of nasal cavity carcinomas  

SciTech Connect (OSTI)

The purpose of this study was to evaluate the differences between volumetric modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) in the treatment of nasal cavity carcinomas. The treatment of 10 patients, who had completed IMRT treatment for resected tumors of the nasal cavity, was replanned with the Philips Pinnacle{sup 3} Version 9 treatment-planning system. The IMRT plans used a 9-beam technique whereas the VMAT (known as SmartArc) plans used a 3-arc technique. Both types of plans were optimized using Philips Pinnacle{sup 3} Direct Machine Parameter Optimization algorithm. IMRT and VMAT plans' quality was compared by evaluating the maximum, minimum, and mean doses to the target volumes and organs at risk, monitor units (MUs), and the treatment delivery time. Our results indicate that VMAT is capable of greatly reducing treatment delivery time and MUs compared with IMRT. The reduction of treatment delivery time and MUs can decrease the effects of intrafractional uncertainties that can occur because of patient movement during treatment delivery. VMAT's plans further reduce doses to critical structures that are in close proximity to the target volume.

Nguyen, Kham, E-mail: khamdiep@gmail.com [School of Health Professions, Medical Dosimetry Program, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (United States); UT MD Anderson Cancer Center, School of Health ProfessionsUnit 2, Houston, TX (United States); Cummings, David; Lanza, Vincent C.; Morris, Kathleen; Wang, Congjun; Sutton, Jordan; Garcia, John [School of Health Professions, Medical Dosimetry Program, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (United States); UT MD Anderson Cancer Center, School of Health ProfessionsUnit 2, Houston, TX (United States)

2013-10-01T23:59:59.000Z

288

In situ high-energy synchrotron radiation study of boehmite formation, growth, and phase transformation to alumina in sub- and supercritical water.  

SciTech Connect (OSTI)

Boehmite (AlOOH) nanoparticles have been synthesized in subcritical (300 bar, 350 C) and supercritical (300 bar, 400 C) water. The formation and growth of AlOOH nanoparticles were studied in situ by small- and wide-angle X-ray scattering (SAXS and WAXS) using 80 keV synchrotron radiation. The SAXS/WAXS data were measured simultaneously with a time resolution greater than 10 s and revealed the initial nucleation of amorphous particles takes place within 10 s with subsequent crystallization after 30 s. No diffraction signals were observed from Al(OH){sub 3} within the time resolution of the experiment, which shows that the dehydration step of the reaction is fast and the hydrolysis step rate-determining. The sizes of the crystalline particles were determined as a function of time. The overall size evolution patterns are similar in sub- and supercritical water, but the growth is faster and the final particle size larger under supercritical conditions. After approximately 5 min, the rate of particle growth decreases in both sub- and supercritical water. Heating of the boehmite nanoparticle suspension allowed an in situ X-ray investigation of the phase transformation of boehmite to aluminium oxide. Under the wet conditions used in this work, the transition starts at 530 C and gives a two-phase product of hydrated and non-hydrated aluminium oxide.

Lock, N.; Bremholm, M.; Christensen, M.; Almer, J .D.; Chen, Y.-S.; Iverson, B. B.; Univ. of Aarhus; Univ. of Chicago; Princeton Univ.

2009-01-01T23:59:59.000Z

289

RADIATION RESEARCH 160, 174185 (2003) 0033-7587/03 $5.00  

E-Print Network [OSTI]

174 RADIATION RESEARCH 160, 174­185 (2003) 0033-7587/03 $5.00 2003 by Radiation Research Society Backbone Radicals. Radiat. Res. 160, 174­185 (2003). In this study, the effects of high-LET radiation inherent in the two radiations. 2003 by Radiation Research Society INTRODUCTION The processes of energy

Simons, Jack

290

RADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND  

E-Print Network [OSTI]

RADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND RADIATION SAFETY MANUAL UNIVERSITY OF MARYLAND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2. Radiation Safety Committee (RSC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.4. Radiation Safety Office (RSO

Rubloff, Gary W.

291

A Prospective Pathologic Study to Define the Clinical Target Volume for Partial Breast Radiation Therapy in Women With Early Breast Cancer  

SciTech Connect (OSTI)

Purpose: To determine an appropriate clinical target volume for partial breast radiation therapy (PBRT) based on the spatial distribution of residual invasive and in situ carcinoma after wide local excision (WLE) for early breast cancer or ductal carcinoma in situ (DCIS). Methods and Materials: We performed a prospective pathologic study of women potentially eligible for PBRT who had re-excision and/or completion mastectomy after WLE for early breast cancer or DCIS. A pathologic assessment protocol was used to determine the maximum radial extension (MRE) of residual carcinoma from the margin of the initial surgical cavity. Women were stratified by the closest initial radial margin width: negative (>1 mm), close (>0 mm and {<=}1 mm), or involved. Results: The study population was composed of 133 women with a median age of 59 years (range, 27-82 years) and the following stage groups: 0 (13.5%), I (40.6%), II (38.3%), and III (7.5%). The histologic subtypes of the primary tumor were invasive ductal carcinoma (74.4%), invasive lobular carcinoma (12.0%), and DCIS alone (13.5%). Residual carcinoma was present in the re-excision and completion mastectomy specimens in 55.4%, 14.3%, and 7.2% of women with an involved, close, and negative margin, respectively. In the 77 women with a noninvolved radial margin, the MRE of residual disease, if present, was {<=}10 mm in 97.4% (95% confidence interval 91.6-99.5) of cases. Larger MRE measurements were significantly associated with an involved margin (P<.001), tumor size >30 mm (P=.03), premenopausal status (P=.03), and negative progesterone receptor status (P=.05). Conclusions: A clinical target volume margin of 10 mm would encompass microscopic residual disease in >90% of women potentially eligible for PBRT after WLE with noninvolved resection margins.

Nguyen, Brandon T., E-mail: Brandon.Nguyen@act.gov.au [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Canberra Hospital, Radiation Oncology Department, Garran, ACT (Australia); Deb, Siddhartha [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia) [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Victorian Cancer Biobank, Cancer Council of Victoria, Carlton, Victoria (Australia); Fox, Stephen [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia)] [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Hill, Prudence [Department of Anatomical Pathology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria (Australia)] [Department of Anatomical Pathology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria (Australia); Collins, Marnie [Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia)] [Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Chua, Boon H. [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia) [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); University of Melbourne, Parkville, Victoria (Australia)

2012-12-01T23:59:59.000Z

292

Burnout in United States Academic Chairs of Radiation Oncology Programs  

SciTech Connect (OSTI)

Purpose: The aims of this study were to determine the self-reported prevalence of burnout in chairs of academic radiation oncology departments, to identify factors contributing to burnout, and to compare the prevalence of burnout with that seen in other academic chair groups. Methods and Materials: An anonymous online survey was administered to the membership of the Society of Chairs of Academic Radiation Oncology Programs (SCAROP). Burnout was measured with the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Results: Questionnaires were returned from 66 of 87 chairs (76% response rate). Seventy-nine percent of respondents reported satisfaction with their current positions. Common major stressors were budget deficits and human resource issues. One-quarter of chairs reported that it was at least moderately likely that they would step down in the next 1 to 2 years; these individuals demonstrated significantly higher emotional exhaustion. Twenty-five percent of respondents met the MBI-HSS criteria for low burnout, 75% for moderate burnout, and none for high burnout. Group MBI-HSS subscale scores demonstrated a pattern of moderate emotional exhaustion, low depersonalization, and moderate personal accomplishment, comparing favorably with other specialties. Conclusions: This is the first study of burnout in radiation oncology chairs with a high response rate and using a validated psychometric tool. Radiation oncology chairs share similar major stressors to other chair groups, but they demonstrate relatively high job satisfaction and lower burnout. Emotional exhaustion may contribute to the anticipated turnover in coming years. Further efforts addressing individual and institutional factors associated with burnout may improve the relationship with work of chairs and other department members.

Kusano, Aaron S. [Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington (United States); Thomas, Charles R., E-mail: thomasch@ohsu.edu [Department of Radiation Medicine, Knight Cancer Institute/Oregon Health and Science University, Portland, Oregon (United States); Bonner, James A. [Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama (United States); DeWeese, Theodore L. [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland (United States); Formenti, Silvia C. [Department of Radiation Oncology, New York University, New York, New York (United States); Hahn, Stephen M. [Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Mittal, Bharat B. [Department of Radiation Oncology, Northwestern University, Chicago, Ilinois (United States)

2014-02-01T23:59:59.000Z

293

Geant4 applications in the heliospheric radiation environment  

E-Print Network [OSTI]

The high energy ionizing radiation environment in the solar system consists of three main sources: the radiation belts, galactic cosmic rays and solar energetic particles. Geant4 is a Monte Carlo radiation transport simulation toolkit, with applications in areas as high energy physics, nuclear physics, astrophysics or medical physics research. In this poster, Geant4 applications to model and study the effects of the heliospheric radiation environment are presented. Specific applications are being developed to study the effect of the radiation environment on detector components, to describe the response and to optimise the design of radiation monitors for future space missions and to predict the radiation environment in Mars surface, orbits and moons.

Pedro Brogueira; Patrcia Gonalves; Ana Keating; Dalmiro Maia; Mrio Pimenta; Bernardo Tom

2007-09-11T23:59:59.000Z

294

A Comparative Study on Human Embryonic Stem Cell Patent Law in the United States, the European Patent Organization, and China  

E-Print Network [OSTI]

With the recent developments in biotechnology, associated patent law issues have been a growing concern since the 1980s. Among all the subcategories within the general field of biotechnology, human embryonic stem cell ...

Zhu, Huan

2011-05-31T23:59:59.000Z

295

WHAT is the radiation budget? The Earth's radiation budget fundamentally comprises of two components. Incoming shortwave  

E-Print Network [OSTI]

WHAT is the radiation budget? The Earth's radiation budget fundamentally comprises of two role in regulating the energy budget either by "resisting" the outflow of thermal energy term decadal variability. WHY study the radiation budget? The net longwave emission is a "proxy

296

Radiation Control (Virginia)  

Broader source: Energy.gov [DOE]

The Department of Health is responsible for regulating radiation and radioactive materials in the Commonwealth of Virginia. Although the Department's Radiation Control Program primarily focuses on...

297

A Sensitivity Study of Radiative Fluxes at the Top of Atmosphere to Cloud-Microphysics and Aerosol Parameters in the Community Atmosphere Model CAM5  

SciTech Connect (OSTI)

In this study, we investigated the sensitivity of net radiative fluxes (FNET) at the top of atmosphere (TOA) to 16 selected uncertain parameters mainly related to the cloud microphysics and aerosol schemes in the Community Atmosphere Model version 5 (CAM5). We adopted a quasi-Monte Carlo (QMC) sampling approach to effectively explore the high dimensional parameter space. The output response variables (e.g., FNET) were simulated using CAM5 for each parameter set, and then evaluated using generalized linear model analysis. In response to the perturbations of these 16 parameters, the CAM5-simulated global annual mean FNET ranges from -9.8 to 3.5 W m-2 compared to the CAM5-simulated FNET of 1.9 W m-2 with the default parameter values. Variance-based sensitivity analysis was conducted to show the relative contributions of individual parameter perturbation to the global FNET variance. The results indicate that the changes in the global mean FNET are dominated by those of cloud forcing (CF) within the parameter ranges being investigated. The size threshold parameter related to auto-conversion of cloud ice to snow is confirmed as one of the most influential parameters for FNET in the CAM5 simulation. The strong heterogeneous geographic distribution of FNET variation shows parameters have a clear localized effect over regions where they are acting. However, some parameters also have non-local impacts on FNET variance. Although external factors, such as perturbations of anthropogenic and natural emissions, largely affect FNET variations at the regional scale, their impact is weaker than that of model internal parameters in terms of simulating global mean FNET in this study. The interactions among the 16 selected parameters contribute a relatively small portion of the total FNET variations over most regions of the globe. This study helps us better understand the CAM5 model behavior associated with parameter uncertainties, which will aid the next step of reducing model uncertainty via calibration of uncertain model parameters with the largest sensitivity.

Zhao, Chun; Liu, Xiaohong; Qian, Yun; Yoon, Jin-Ho; Hou, Zhangshuan; Lin, Guang; McFarlane, Sally A.; Wang, Hailong; Yang, Ben; Ma, Po-Lun; Yan, Huiping; Bao, Jie

2013-11-08T23:59:59.000Z

298

Properties of Natural Radiation and Radioactivity  

SciTech Connect (OSTI)

Ubiquitous natural sources of radiation and radioactive material (naturally occurring radioactive material, NORM) have exposed humans throughout history. To these natural sources have been added technologically-enhanced naturally occurring radioactive material (TENORM) sources and human-made (anthropogenic) sources. This chapter describes the ubiquitous radiation sources that we call background, including primordial radionuclides such as 40K, 87Rb, the 232Th series, the 238U series, and the 235U series; cosmogenic radionuclides such as 3H and 14C; anthropogenic radionuclides such as 3H, 14C, 137Cs, 90Sr, and 129I; radiation from space; and radiation from technologically-enhanced concentrations of natural radionuclides, particularly the short-lived decay products of 222Rn ("radon") and 220Rn ("thoron") in indoor air. These sources produce radiation doses to people principally via external irradiation or internal irradiation following intakes by inhalation or ingestion. The effective doses from each are given, with a total of 3.11 mSv y-1 (311 mrem y-1) to the average US resident. Over 2.5 million US residents receive over 20 mSv y-1 (2 rem y-1), primarily due to indoor radon. Exposure to radiation from NORM and TENORM produces the largest fraction of ubiquitous background exposure to US residents, on the order of 2.78 mSv (278 mrem) or about 89%. This is roughly 45% of the average annual effective dose to a US resident of 6.2 mSv y-1 (620 mrem y-1) that includes medical (48%), consumer products and air travel (2%), and occupational and industrial (0.1%). Much of this chapter is based on National Council on Radiation Protection and Measurements (NCRP) Report No. 160, "Ionizing Radiation Exposure of the Population of the United States," for which the author chaired the subcommittee that wrote Chapter 3 on "Ubiquitous Background Radiation."

Strom, Daniel J.

2009-07-13T23:59:59.000Z

299

Device for calibrating a radiation detector system  

DOE Patents [OSTI]

A device is disclosed for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a ''shield plate'' or shell, and an opposing ''source plate'' containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects. 3 figures.

McFee, M.C.; Kirkham, T.J.; Johnson, T.H.

1994-12-27T23:59:59.000Z

300

Device for calibrating a radiation detector system  

DOE Patents [OSTI]

A device for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a "shield plate" or shell, and an opposing "source plate" containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, heart, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects.

Mc Fee, Matthew C. (New Ellenton, SC); Kirkham, Tim J. (Beech Island, SC); Johnson, Tippi H. (Aiken, SC)

1994-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Motexafin-Gadolinium and Involved Field Radiation Therapy for Intrinsic Pontine Glioma of Childhood: A Children's Oncology Group Phase 2 Study  

SciTech Connect (OSTI)

Purpose: To evaluate the effects on 1-year event-free survival (EFS) and overall survival (OS) of combining motexafin and gadolinium (MGd), a potent radiosensitizer, with daily fractionated radiation therapy in children with newly diagnosed intrinsic pontine gliomas. Methods and Materials: Patients with newly diagnosed intrinsic pontine glioma were treated with MGd daily for 5 consecutive days each week, for a total of 30 doses. Patients received a 5- to 10-min intravenous bolus of MGd, 4.4 mg/kg/day, given 2 to 5 h prior to standard dose irradiation. Radiation therapy was administered at a daily dose of 1.8 Gy for 30 treatments over 6 weeks. The total dose was 54 Gy. Results: Sixty eligible children received MGd daily, concurrent with 6 weeks of radiation therapy. The estimated 1-year EFS was 18% {+-} 5%, and the estimated 1-year OS was 53% {+-} 6.5%. The most common grade 3 to 4 toxicities were lymphopenia, transient elevation of liver transaminases, and hypertension. Conclusions: Compared to historical controls, the addition of MGd to a standard 6-week course of radiation did not improve the survival of pediatric patients with newly diagnosed intrinsic pontine gliomas.

Bradley, Kristin A., E-mail: bradley@humonc.wisc.edu [Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (United States); Zhou Tianni [Department of Preventive Medicine, University of Southern California, Los Angeles, California (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, California (United States); McNall-Knapp, Rene Y. [Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States)] [Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States); Jakacki, Regina I. [Division of Pediatric Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States)] [Division of Pediatric Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Levy, Adam S. [Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York (United States)] [Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York (United States); Vezina, Gilbert [Department of Radiology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC (United States)] [Department of Radiology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC (United States); Pollack, Ian F. [Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (United States)] [Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (United States)

2013-01-01T23:59:59.000Z

302

Structural study of the interaction between poxvirus-encoded cc chemokine inhibitor vcci and human mip-1beta  

E-Print Network [OSTI]

poxvirus since the early 1990s (88), the function of this protein was unveiled in 1997 by Craig A. Smith and co-workers (85). These researchers used an 12 epitope-tagged soluble form of vCCI from variola virus (the causative agent of human small pox...

Zhang, Li

2008-10-10T23:59:59.000Z

303

Ris National Laboratory DTU Radiation Research Department  

E-Print Network [OSTI]

the atmosphere to the human thyroid via the food chain and inhalation, and found that the radiation dose of 131 I can not only cause external irradiation of the skin, but also an internal irradiation of the thyroid and whole body. In addition, radioiodine deposited on clothes and hair can also cause skin irradiation

304

Radiation Field on Superspace  

E-Print Network [OSTI]

We study the dynamics of multiwormhole configurations within the framework of the Euclidean Polyakov approach to string theory, incorporating a modification to the Hamiltonian which makes it impossible to interpret the Coleman Alpha parameters of the effective interactions as a quantum field on superspace, reducible to an infinite tower of fields on space-time. We obtain a Planckian probability measure for the Alphas that allows $\\frac{1}{2}\\alpha^{2}$ to be interpreted as the energy of the quanta of a radiation field on superspace whose values may still fix the coupling constants.

P. F. Gonzalez-Diaz

1994-03-18T23:59:59.000Z

305

Cellular and molecular research to reduce uncertainties in estimates of health effects from low-level radiation  

SciTech Connect (OSTI)

A study was undertaken by five radiation scientists to examine the feasibility of reducing the uncertainties in the estimation of risk due to protracted low doses of ionizing radiation. In addressing the question of feasibility, a review was made by the study group: of the cellular, molecular, and mammalian radiation data that are available; of the way in which altered oncogene properties could be involved in the loss of growth control that culminates in tumorigenesis; and of the progress that had been made in the genetic characterizations of several human and animal neoplasms. On the basis of this analysis, the study group concluded that, at the present time, it is feasible to mount a program of radiation research directed at the mechanism(s) of radiation-induced cancer with special reference to risk of neoplasia due to protracted, low doses of sparsely ionizing radiation. To implement a program of research, a review was made of the methods, techniques, and instruments that would be needed. This review was followed by a survey of the laboratories and institutions where scientific personnel and facilities are known to be available. A research agenda of the principal and broad objectives of the program is also discussed. 489 refs., 21 figs., 14 tabs.

Elkind, M.M.; Bedford, J.; Benjamin, S.A.; Waldren, C.A. (Colorado State Univ., Fort Collins, CO (USA)); Gotchy, R.L. (Science Applications International Corp., McLean, VA (USA))

1990-10-01T23:59:59.000Z

306

Medium-induced multi-photon radiation  

E-Print Network [OSTI]

We study the spectrum of multi-photon radiation off a fast quark in medium in the BDMPS/ASW approach. We reproduce the medium-induced one-photon radiation spectrum in dipole approximation, and go on to calculate the two-photon radiation in the Moli\\`{e}re limit. We find that in this limit the LPM effect holds for medium-induced two-photon ladder emission.

Hao Ma; Carlos A. Salgado; Konrad Tywoniuk

2011-05-29T23:59:59.000Z

307

Radiation effects in optoelectronic devices. [Review  

SciTech Connect (OSTI)

Purpose of this report is to provide not only a summary of radiation damage studies at Sandia National Laboratories, but also of those in the literature on the components of optoelectronic systems: light emitting diodes (LEDs), laser diodes, photodetectors, optical fibers, and optical isolators. This review of radiation damage in optoelectronic components is structured according to device type. In each section, a brief discussion of those device properties relevant to radiation effects is given.

Barnes, C.E.; Wiczer, J.J.

1984-05-01T23:59:59.000Z

308

A Research Agenda for Radiation Oncology: Results of the Radiation Oncology Institute's Comprehensive Research Needs Assessment  

SciTech Connect (OSTI)

Purpose: To promote the rational use of scarce research funding, scholars have developed methods for the systematic identification and prioritization of health research needs. The Radiation Oncology Institute commissioned an independent, comprehensive assessment of research needs for the advancement of radiation oncology care. Methods and Materials: The research needs assessment used a mixed-method, qualitative and quantitative social scientific approach, including structured interviews with diverse stakeholders, focus groups, surveys of American Society for Radiation Oncology (ASTRO) members, and a prioritization exercise using a modified Delphi technique. Results: Six co-equal priorities were identified: (1) Identify and develop communication strategies to help patients and others better understand radiation therapy; (2) Establish a set of quality indicators for major radiation oncology procedures and evaluate their use in radiation oncology delivery; (3) Identify best practices for the management of radiation toxicity and issues in cancer survivorship; (4) Conduct comparative effectiveness studies related to radiation therapy that consider clinical benefit, toxicity (including quality of life), and other outcomes; (5) Assess the value of radiation therapy; and (6) Develop a radiation oncology registry. Conclusions: To our knowledge, this prioritization exercise is the only comprehensive and methodologically rigorous assessment of research needs in the field of radiation oncology. Broad dissemination of these findings is critical to maximally leverage the impact of this work, particularly because grant funding decisions are often made by committees on which highly specialized disciplines such as radiation oncology are not well represented.

Jagsi, Reshma, E-mail: rjagsi@med.umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Bekelman, Justin E. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States); Brawley, Otis W. [Department of Hematology and Oncology, Emory University, and American Cancer Society, Atlanta, Georgia (United States)] [Department of Hematology and Oncology, Emory University, and American Cancer Society, Atlanta, Georgia (United States); Deasy, Joseph O. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Le, Quynh-Thu [Department of Radiation Oncology, Stanford University, Stanford, CA (United States)] [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Michalski, Jeff M. [Department of Radiation Oncology, Washington University, St. Louis, MO (United States)] [Department of Radiation Oncology, Washington University, St. Louis, MO (United States); Movsas, Benjamin [Department of Radiation Oncology, Henry Ford Health System, Detroit, MI (United States)] [Department of Radiation Oncology, Henry Ford Health System, Detroit, MI (United States); Thomas, Charles R. [Department of Radiation Oncology, Oregon Health and Sciences University, Portland, OR (United States)] [Department of Radiation Oncology, Oregon Health and Sciences University, Portland, OR (United States); Lawton, Colleen A. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)] [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)] [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)

2012-10-01T23:59:59.000Z

309

Plutonium radiation surrogate  

DOE Patents [OSTI]

A self-contained source of gamma-ray and neutron radiation suitable for use as a radiation surrogate for weapons-grade plutonium is described. The source generates a radiation spectrum similar to that of weapons-grade plutonium at 5% energy resolution between 59 and 2614 keV, but contains no special nuclear material and emits little .alpha.-particle radiation. The weapons-grade plutonium radiation surrogate also emits neutrons having fluxes commensurate with the gamma-radiation intensities employed.

Frank, Michael I. (Dublin, CA)

2010-02-02T23:59:59.000Z

310

Studies of 3D-cloud optical depth from small to very large values, and of the radiation and remote sensing impacts of larger-drop clustering  

SciTech Connect (OSTI)

We have basically completed all the goals stated in the previous proposal and published or submitted journal papers thereon, the only exception being First-Principles Monte Carlo which has taken more time than expected. We finally finished the comprehensive book on 3D cloud radiative transfer (edited by Marshak and Davis and published by Springer), with many contributions by ARM scientists; this book was highlighted in the 2005 ARM Annual Report. We have also completed (for now) our pioneering work on new models of cloud drop clustering based on ARM aircraft FSSP data, with applications both to radiative transfer and to rainfall. This clustering work was highlighted in the FY07 Our Changing Planet (annual report of the US Climate Change Science Program). Our group published 22 papers, one book, and 5 chapters in that book, during this proposal period. All are listed at the end of this section. Below, we give brief highlights of some of those papers.

None

2007-05-04T23:59:59.000Z

311

Atomistic simulations of radiation damage in amorphous metal alloys  

E-Print Network [OSTI]

While numerous fundamental studies have characterized the atomic-level radiation response mechanisms in irradiated crystalline alloys, comparatively little is known regarding the mechanisms of radiation damage in amorphous ...

Baumer, Richard E. (Richard Edward)

2013-01-01T23:59:59.000Z

312

22.01 Introduction to Ionizing Radiation, Fall 2003  

E-Print Network [OSTI]

Introduction to basic properties of ionizing radiations and their uses in medicine, industry, science, and environmental studies. Discusses natural and man-made radiation sources, energy deposition and dose calculations, ...

Coderre, Jeffrey A.

313

Radiator Labs | Department of Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of steam buildings. Radiator Labs developed a mechanism that allows heating systems to control heat transfer at each radiator. The Radiator Labs design utilizes an...

314

The universal radiative transport equation  

E-Print Network [OSTI]

THE UNIVERSAL RADIATIVE TRANSPORT EQUATION Rudolph W.The Universal Radiative Transport Equation Rudolph W.The various radiative transport equations used in general

Preisendorfer, Rudolph W

1959-01-01T23:59:59.000Z

315

Tachyons and Gravitational Cherenkov Radiation  

E-Print Network [OSTI]

AND GRAVITATIONAL CHERENKOV RADIATION CHARLES SCHWARTZwould emit gravitational radiation. It is very small.gravitational waves; Cherenkov radiation. In a recent work,

Schwartz, Charles

2011-01-01T23:59:59.000Z

316

Radiation Safety Program Annual Review  

E-Print Network [OSTI]

........................................................................10 AREA RADIATION SURVEYS AND CONTAMINATION CONTROL...........................................11.....................................................................................................13 RADIOACTIVE WASTE MANAGEMENT meetings of the Radiation Safety Committee where new users and uses of radioactive materials, radiation

Lyubomirsky, Ilya

317

WI Radiation Protection  

Broader source: Energy.gov [DOE]

This statute seeks to regulate radioactive materials, to encourage the constructive uses of radiation, and to prohibit and prevent exposure to radiation in amounts which are or may be detrimental...

318

Maryland Radiation Act (Maryland)  

Broader source: Energy.gov [DOE]

The policy of the state is to provide for the constructive use of radiation and control radiation emissions. This legislation authorizes the Department of the Environment to develop comprehensive...

319

Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients  

SciTech Connect (OSTI)

Purpose: MicroRNAs (miRNAs), a class of noncoding small RNAs that regulate gene expression, are involved in numerous physiologic processes in normal and malignant cells. Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation exposure. Methods and Materials: Blood from 8 radiotherapy patients in complete remission 1 or 2 was collected immediately before and 4 hours after total body irradiation with 1.25 Gy x-rays. Both miRNA and gene expression changes were measured by means of quantitative polymerase chain reaction and microarray hybridization, respectively. Hierarchic clustering, multidimensional scaling, class prediction, and gene ontology analysis were performed to investigate the potential of miRNAs to serve as radiation biomarkers and to elucidate their likely physiologic roles in the radiation response. Results: The expression levels of 45 miRNAs were statistically significantly upregulated 4 hours after irradiation with 1.25 Gy x-rays, 27 of them in every patient. Nonirradiated and irradiated samples form separate clusters in hierarchic clustering and multidimensional scaling. Out of 223 differentially expressed genes, 37 were both downregulated and predicted targets of the upregulated miRNAs. Paired and unpaired miRNA-based classifiers that we developed can predict the class membership of a sample with unknown irradiation status, with accuracies of 100% when all 45 upregulated miRNAs are included. Both miRNA control of and gene involvement in biologic processes such as hemopoiesis and the immune response are increased after irradiation, whereas metabolic processes are underrepresented among all differentially expressed genes and the genes controlled by miRNAs. Conclusions: Exposure to ionizing radiation leads to the upregulation of the expression of a considerable proportion of the human miRNAome of peripheral blood cells. These miRNA expression signatures can be used as biomarkers of radiation exposure.

Templin, Thomas; Paul, Sunirmal; Amundson, Sally A.; Young, Erik F. [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Barker, Christopher A.; Wolden, Suzanne L. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Smilenov, Lubomir B., E-mail: lbs5@columbia.ed [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States)

2011-06-01T23:59:59.000Z

320

Polarization of Cerenkov radiation in anisotropic media  

SciTech Connect (OSTI)

Using the method of Stokes parameters, we examine the polarization of Cerenkov radiation in anisotropic media. The study reveals that the radiation is totally polarized and that circular polarization is purely a quantum effect. We examine two cases; when the particle initially moves along the optical axis and when the particle initially moves perpendicular to the optical axis.

Orisa, B.D. [Moi Univ., Eldoret (Kenya)

1995-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

tight environment high radiation area  

E-Print Network [OSTI]

#12;Irradiation Studies of Optical Components - II CERN, week of Oct. 24, 2005 1.4 GeV proton beam 4 x· tight environment · high radiation area · non-serviceable area · passive components · optics only, no active electronics · transmit image through flexible fiber bundle Optical Diagnostics 01-13-2006 1 #12

McDonald, Kirk

322

RADIONUCLIDE RADIATION PROTECTION  

E-Print Network [OSTI]

COPYRIGHT 2002 Nuclear Technology Publishing #12;3 #12;4 #12;5 Radiation Protection Dosimetry Vol. 98, No'Energie Atomique, CEA/Saclay, France ISBN 1 870965 87 6 RADIATION PROTECTION DOSIMETRY Vol. 98 No 1, 2002 Published by Nuclear Technology Publishing #12;RADIONUCLIDE AND RADIATION PROTECTION DATA HANDBOOK 2nd Edition (2002

Healy, Kevin Edward

323

Radiation Damping with Inhomogeneous  

E-Print Network [OSTI]

Radiation Damping with Inhomogeneous Broadening: Limitations of the Single Bloch Vector Model of inhomoge- neous broadening on radiation damping of free precession signals have been described using 13: 1 7, 2001 KEY WORDS: radiation damping; FID shape; inhomogeneous broadening The phenomenon

Augustine, Mathew P.

324

astroph/9507030 Gravitational Radiation  

E-Print Network [OSTI]

astro­ph/9507030 10 Jul 95 Gravitational Radiation and Very Long Baseline Interferometry Ted Pyne of gravitational radiation on astrometric observations. We derive an equation for the time delay measured by two antennae observing the same source in an Einstein­de Sitter spacetime containing gravitational radiation

Fygenson, Deborah Kuchnir

325

Radiation Processing -an overview  

E-Print Network [OSTI]

of radiation · Facilities ­ Gamma ­ electrons ­ X-ray ­ Safety · Sterilisation of medical devices · Food irradiation · Material modification #12;3 Content ­ Part 2 · Environmental applications · Other applications Radiation · Energy in the form of waves or moving subatomic particles Irradiation · Exposure to radiation

326

Sunitinib Plus Androgen Deprivation and Radiation Therapy for Patients With Localized High-Risk Prostate Cancer: Results From a Multi-institutional Phase 1 Study  

SciTech Connect (OSTI)

Purpose: To evaluate the feasibility of administering sunitinib in combination with androgen deprivation therapy and external-beam intensity modulated radiation therapy (XRT) in patients with localized high-risk prostate cancer. Methods and Materials: Seventeen men with localized adenocarcinoma of the prostate with cT2c-cT4 or Gleason 8-10 or prostate-specific antigen >20 ng/mL received initial androgen deprivation (leuprolide 22.5 mg every 12 weeks plus oral bicalutamide 50 mg daily) for 4-8 weeks before oral sunitinib 12.5, 25, or 37.5 mg daily for 4 weeks as lead-in, then concurrently with and 4 weeks after XRT (75.6 Gy in 42 fractions to prostate and seminal vesicles). A 3+3 sequential dose-escalation design was used to assess the frequency of dose-limiting toxicity (DLT) and establish a maximal tolerated dose of sunitinib. Results: Sunitinib at 12.5- and 25-mg dose levels was well tolerated. The first 4 patients enrolled at 37.5 mg experienced a DLT during lead-in, and a drug interaction between sunitinib and bicalutamide was suspected. The protocol was revised and concurrent bicalutamide omitted. Of the next 3 patients enrolled at 37.5 mg, 2 of 3 receiving concurrent therapy experienced DLTs during radiation: grade 3 diarrhea and grade 3 proctitis, respectively. Only 1 of 7 patients completed sunitinib at 37.5 mg daily, whereas 3 of 3 patients (25 mg as starting dose) and 3 of 4 patients (25 mg as reduced dose) completed therapy. Conclusions: The feasibility of combined vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR) inhibitor therapy, androgen deprivation, and radiation therapy for prostate cancer was established. Using a daily dosing regimen with lead-in, concurrent, and post-XRT therapy, the recommended phase 2 dose of sunitinib is 25 mg daily.

Corn, Paul G., E-mail: pcorn@mdanderson.org [Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Song, Danny Y. [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland (United States)] [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland (United States); Heath, Elisabeth; Maier, Jordan [Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (United States)] [Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (United States); Meyn, Raymond [Department of Experimental Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Experimental Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); DePetrillo, Thomas A. [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts (United States); Mathew, Paul, E-mail: pmathew@tuftsmedicalcenter.org [Department of Hematology-Oncology, Tufts Medical Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)] [Department of Hematology-Oncology, Tufts Medical Center, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2013-07-01T23:59:59.000Z

327

Modeling human risk: Cell & molecular biology in context  

SciTech Connect (OSTI)

It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high dose-rate, whereas in space, with the exception of solar particle events, radiation exposures will be low-dose, low dose-rate; (3) Although it has been established that the virtual absence of gravity in space has a profound effect on human physiology, it is not clear whether these effects will act synergistically with those of radiation exposure. A select panel will evaluate the utilizing experiments and models to accurately predict the risks associated with exposure to HZE particles. Topics of research include cellular and tissue response, health effects associated with radiation damage, model animal systems, and critical markers of Radiation response.

NONE

1997-06-01T23:59:59.000Z

328

Radiation Shielding and Radiological Protection  

E-Print Network [OSTI]

Radiation Shielding and Radiological Protection J. Kenneth Shultis Richard E. Faw Department@triad.rr.com Radiation Fields and Sources ................................................ . Radiation Field Variables........................................................... .. Direction and Solid Angle Conventions ......................................... .. Radiation Fluence

Shultis, J. Kenneth

329

TERSat: Trapped Energetic Radiation Satellite  

E-Print Network [OSTI]

Radiation damage caused by interactions with high-energy particles in the Van Allen Radiation Belts is a leading

Clements, Emily B.

2012-01-01T23:59:59.000Z

330

Generation of circularly polarized radiation from a compact plasma-based extreme ultraviolet light source for tabletop X-ray magnetic circular dichroism studies  

SciTech Connect (OSTI)

Generation of circularly polarized light in the extreme ultraviolet (EUV) spectral region (about 25 eV250 eV) is highly desirable for applications in spectroscopy and microscopy but very challenging to achieve in a small-scale laboratory. We present a compact apparatus for generation of linearly and circularly polarized EUV radiation from a gas-discharge plasma light source between 50 eV and 70 eV photon energy. In this spectral range, the 3p absorption edges of Fe (54 eV), Co (60 eV), and Ni (67 eV) offer a high magnetic contrast often employed for magneto-optical and electron spectroscopy as well as for magnetic imaging. We simulated and designed an instrument for generation of linearly and circularly polarized EUV radiation and performed polarimetric measurements of the degree of linear and circular polarization. Furthermore, we demonstrate first measurements of the X-ray magnetic circular dichroism at the Co 3p absorption edge with a plasma-based EUV light source. Our approach opens the door for laboratory-based, element-selective spectroscopy of magnetic materials and spectro-microscopy of ferromagnetic domains.

Wilson, Daniel; Rudolf, Denis, E-mail: d.rudolf@fz-juelich.de; Juschkin, Larissa [RWTH Aachen University, Experimental Physics of EUV, Steinbachstrae 15, 52074 Aachen (Germany); Forschungszentrum Jlich GmbH, Peter Grnberg Institut (PGI-9), JARA-FIT, 52425 Jlich (Germany); Weier, Christian; Adam, Roman; Schneider, Claus M. [Forschungszentrum Jlich GmbH, Peter Grnberg Institut (PGI-6), JARA-FIT, 52425 Jlich (Germany); Winkler, Gerrit; Frmter, Robert [Institut fr Angewandte Physik, Universitt Hamburg, Jungiusstrae 11, 20355 Hamburg (Germany); Danylyuk, Serhiy [RWTH Aachen University, Chair for Technology of Optical Systems, JARA-FIT, Steinbachstrae 15, 52074 Aachen (Germany); Bergmann, Klaus [Fraunhofer Institute for Laser Technology, Steinbachstrasse 15, 52074 Aachen (Germany); Grtzmacher, Detlev [Forschungszentrum Jlich GmbH, Peter Grnberg Institut (PGI-9), JARA-FIT, 52425 Jlich (Germany)

2014-10-15T23:59:59.000Z

331

NREL/Habitat for Humanity Zero Energy Home: A Cold-Climate Case Study for Affordable Zero Energy Homes  

SciTech Connect (OSTI)

The design of this 1,280-square-foot, three-bedroom Habitat for Humanity of Metro Denver zero energy home carefully combines envelope efficiency, efficient equipment, appliances and lighting, and passive and active solar features to reach the zero energy goal. The home was designed with an early version (July 22, 2004) of the BEOpt building optimization software; DOE2 and TRNSYS were used to perform additional analysis. This engineering approach was tempered by regular discussions with Habitat construction staff and volunteers. These discussions weighed the applicability of the optimized solutions to the special needs and economics of a Habitat house--moving the design toward simple, easily maintained mechanical systems and volunteer-friendly construction techniques. A data acquisition system was installed in the completed home to monitor its performance.

Norton, P.; Christensen, C.; Hancock, E.; Barker, G.; Reeves, P.

2008-06-01T23:59:59.000Z

332

Radiation Related Terms Basic Terms  

E-Print Network [OSTI]

Radiation Related Terms Basic Terms Radiation Radiation is energy in transit in the form of high not carry enough energy to separate molecules or remove electrons from atoms. Ionizing radiation Ionizing radiation is radiation with enough energy so that during an interaction with an atom, it can remove tightly

Vallino, Joseph J.

333

Radiation: Facts, Risks and Realities  

E-Print Network [OSTI]

of Radiation 3 Understanding Radiation Risks 6 Naturally Occurring (Background) Radiation 7 Man-Made Radiation, beta particles and gamma rays. Other types, such as x-rays, can occur naturally or be machine-produced. Scientists have also learned that radiation sources are naturally all around us. Radiation can come from

334

Behavior of Electric Current Subjected to ELF Electromagnetic Radiation  

E-Print Network [OSTI]

Gravitational effects produced by ELF electromagnetic radiation upon the electric current in a conductor are studied. An apparatus has been constructed to test the behavior of current subjected to ELF radiation. The experimental results are in agreement with theoretical predictions and show that ELF radiation can cause transitory interruptions in electric current conduction.

Fran De Aquino

2002-10-05T23:59:59.000Z

335

The myth of cell phone radiation  

E-Print Network [OSTI]

We discuss the purported link between cell phone radiation and cancer. We show that it is inconsistent with the photoelectric effect, and that epidemiological studies of any link have no scientific basis.

Natarajan, Vasant

2012-01-01T23:59:59.000Z

336

The myth of cell phone radiation  

E-Print Network [OSTI]

We discuss the purported link between cell-phone radiation and cancer. We show that it is inconsistent with the photoelectric effect, and that epidemiological studies of any link have no scientific basis.

Vasant Natarajan

2012-11-22T23:59:59.000Z

337

Human-machine interface (HMI) report for 241-SY-101 data acquisition [and control] system (DACS) upgrade study  

SciTech Connect (OSTI)

This report provides an independent evaluation of information for a Windows based Human Machine Interface (HMI) to replace the existing DOS based Iconics HMI currently used in the Data Acquisition and Control System (DACS) used at Tank 241-SY-101. A fundamental reason for this evaluation is because of the difficulty of maintaining the system with obsolete, unsupported software. The DACS uses a software operator interface (Genesis for DOS HMI) that is no longer supported by its manufacturer, Iconics. In addition to its obsolescence, it is complex and difficult to train additional personnel on. The FY 1997 budget allocated $40K for phase 1 of a software/hardware upgrade that would have allowed the old DOS based system to be replaced by a current Windows based system. Unfortunately, budget constraints during FY 1997 has prompted deferral of the upgrade. The upgrade needs to be performed at the earliest possible time, before other failures render the system useless. Once completed, the upgrade could alleviate other concerns: spare pump software may be able to be incorporated into the same software as the existing pump, thereby eliminating the parallel path dilemma; and the newer, less complex software should expedite training of future personnel, and in the process, require that less technical time be required to maintain the system.

Truitt, R.W.

1997-10-22T23:59:59.000Z

338

RHOBOT: Radiation hardened robotics  

SciTech Connect (OSTI)

A survey of robotic applications in radioactive environments has been conducted, and analysis of robotic system components and their response to the varying types and strengths of radiation has been completed. Two specific robotic systems for accident recovery and nuclear fuel movement have been analyzed in detail for radiation hardness. Finally, a general design approach for radiation-hardened robotics systems has been developed and is presented. This report completes this project which was funded under the Laboratory Directed Research and Development program.

Bennett, P.C.; Posey, L.D. [Sandia National Labs., Albuquerque, NM (United States)

1997-10-01T23:59:59.000Z

339

Solar radiation intensity calculations  

E-Print Network [OSTI]

SOLAR RADIATION INTENSITY CALCULATIONS A Thesis by RANDOLPH STEVEN LEVINE Submitted to the Graduate College of Texas A&M University in partia'l fulfillment of the requirement for the degree of MASTER OF SCIENCE December 1978 Major Subject...: Physics SOLAR RADIATION INTENSITY CALCULATIONS A Thesis by RANDOLPH STEVEN LEVINE Approved as to style and content by: (Chairman of Committee) (Member) (Member) ( member) (Head of Department) December 1978 f219 037 ABSTRACT Solar Radiation...

Levine, Randolph Steven

1978-01-01T23:59:59.000Z

340

Institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: A case study  

E-Print Network [OSTI]

Wolff M, Cirillo P, Sholtz R: DDT and breast cancer in youngeffects of early exposure to DDT. The study reanalyzed bloodto the highest levels of DDT before mid-adoles- cence had a

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Atomic Radiation (Illinois)  

Broader source: Energy.gov [DOE]

This article states permissible levels of radiation in unrestricted areas, environmental standards for uranium fuel cycle and information about notification of incidents.

342

Radiation Hazards Program (Minnesota)  

Broader source: Energy.gov [DOE]

These regulations, promulgated by the Department of Health, set allowable radiation standards and mitigation practices, as well as procedures for the transportation of hazardous material.

343

Rotating bubble membrane radiator  

DOE Patents [OSTI]

A heat radiator useful for expelling waste heat from a power generating system aboard a space vehicle is disclosed. Liquid to be cooled is passed to the interior of a rotating bubble membrane radiator, where it is sprayed into the interior of the bubble. Liquid impacting upon the interior surface of the bubble is cooled and the heat radiated from the outer surface of the membrane. Cooled liquid is collected by the action of centrifical force about the equator of the rotating membrane and returned to the power system. Details regarding a complete space power system employing the radiator are given.

Webb, Brent J. (West Richland, WA); Coomes, Edmund P. (West Richland, WA)

1988-12-06T23:59:59.000Z

344

Radiation Pressure in Massive Star Formation  

E-Print Network [OSTI]

Stars with masses of >~ 20 solar masses have short Kelvin times that enable them to reach the main sequence while still accreting from their natal clouds. The resulting nuclear burning produces a huge luminosity and a correspondingly large radiation pressure force on dust grains in the accreting gas. This effect may limit the upper mass of stars that can form by accretion. Indeed, simulations and analytic calculations to date have been unable to resolve the mystery of how stars of 50 solar masses and up form. We present two new ideas to solve the radiation pressure problem. First, we use three-dimensional radiation hydrodynamic adaptive mesh refinement simulations to study the collapse of massive cores. We find that in three dimensions a configuration in which radiation holds up an infalling envelope is Rayleigh-Taylor unstable, leading radiation driven bubbles to collapse and accretion to continue. We also present Monte Carlo radiative transfer calculations showing that the cavities created by protostellar winds provides a valve that allow radiation to escape the accreting envelope, further reducing the ability of radiation pressure to inhibit accretion.

Mark R. Krumholz; Richard I. Klein; Christopher F. McKee

2005-10-14T23:59:59.000Z

345

Radiation physics, biophysics, and radiation biology  

SciTech Connect (OSTI)

The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

Hall, E.J.

1992-05-01T23:59:59.000Z

346

A study of human plasma lipid and lipoprotein responses to a diet high in oleic acid derived from pecans  

E-Print Network [OSTI]

Pecans contain 68 gm fat per 100 gm with 66-70% as MUFA, primarily oleic acid. As a rich source of MUFA, pecans should represent a non-hyperlipidemic fat addition in isocaloric diets of equivalent SFA content. In this study hypercholesterolemic...

Barloon, Jessica Lynn

2001-01-01T23:59:59.000Z

347

SCIENTIFIC CORRESPONDENCE Radiation doses  

E-Print Network [OSTI]

SCIENTIFIC CORRESPONDENCE Radiation doses and cancert-A T. w- - SIR- In February 1990, the Soviet. Nikipelov et al. published in g Priroda (Nature)' the radiation doses for each year, averaged over environmental impact on the Gulf waters is rapidly ex- ported to the Arabian Sea and then to the Indian Ocean

Shlyakhter, Ilya

348

Radiative Flux Analysis  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The Radiative Flux Analysis is a technique for using surface broadband radiation measurements for detecting periods of clear (i.e. cloudless) skies, and using the detected clear-sky data to fit functions which are then used to produce continuous clear-sky estimates. The clear-sky estimates and measurements are then used in various ways to infer cloud macrophysical properties.

Long, Chuck [NOAA

349

Radiation-resistant microorganism  

DOE Patents [OSTI]

An isolated and purified bacterium is provided which was isolated from a high-level radioactive waste site of mixed waste. The isolate has the ability to degrade a wide variety of organic contaminants while demonstrating high tolerance to ionizing radiation. The organism is uniquely suited to bioremediation of a variety or organic contaminants while in the presence of ionizing radiation.

Fliermans, Carl B.

2010-06-15T23:59:59.000Z

350

Glycolysis and pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-13C2 glucose  

E-Print Network [OSTI]

to lactate, which recycles NADH (reduced nicotinamide-adenine dinucleotide) to NAD+, enabling further glucose molecules to be processed by glycolysis. The PPP, also termed the hexose monophosphate shunt, is a biosynthetic pathway that constitutes a... to hypoxia and/or mitochondrial dysfunction, though the exact nature of the latter remains unclear. In a combined positron emission tomography (PET) (oxygen-15 and fluorodeoxyglucose (18F)) and microdialysis study, Vespa et al. (2005) reported...

Jalloh, Ibrahim; Carpenter, Keri L. H.; Grice, Peter; Howe, Duncan J.; Mason, Andrew; Gallagher, Clare N.; Helmy, Adel; Murphy, Michael P.; Menon, David K.; Carpenter, T. Adrian; Pickard, John D.; Hutchinson, Peter J.

2014-01-01T23:59:59.000Z

351

Nuclear radiation actuated valve  

DOE Patents [OSTI]

A nuclear radiation actuated valve for a nuclear reactor. The valve has a valve first part (such as a valve rod with piston) and a valve second part (such as a valve tube surrounding the valve rod, with the valve tube having side slots surrounding the piston). Both valve parts have known nuclear radiation swelling characteristics. The valve's first part is positioned to receive nuclear radiation from the nuclear reactor's fuel region. The valve's second part is positioned so that its nuclear radiation induced swelling is different from that of the valve's first part. The valve's second part also is positioned so that the valve's first and second parts create a valve orifice which changes in size due to the different nuclear radiation caused swelling of the valve's first part compared to the valve's second part. The valve may be used in a nuclear reactor's core coolant system.

Christiansen, David W. (Kennewick, WA); Schively, Dixon P. (Richland, WA)

1985-01-01T23:59:59.000Z

352

Zemax simulations of diffraction and transition radiation  

E-Print Network [OSTI]

Diffraction Radiation (DR) and Transition Radiation (TR) are produced when a relativistic charged particle moves in the vicinity of a medium or through a medium respectively. The target atoms are polarised by the electric field of the charged particle, which then oscillate thus emitting radiation with a very broad spectrum. The spatialspectral properties of DR/TR are sensitive to various electron beam parameters. Several projects aim to measure the transverse (vertical) beam size using DR or TR. This paper reports on how numerical simulations using Zemax can be used to study such a system.

Aumeyr, T; Bobb, L M; Bolzon, B; Lefevre, T; Mazzoni, S; Billing, M G

2013-01-01T23:59:59.000Z

353

Issues in Low Dose Radiation Biology: The Controversy Continues. A Perspective  

SciTech Connect (OSTI)

Both natural and man-made sources of ionizing radiation contribute to human exposure and consequently pose a risk to human health. Much of this is unavoidable, e.g., natural background radiation, and as the use of radiation in modern medicine and industry increases so does the potential health risk. This perspective reflects the authors view of current issues in low dose radiation biology research, highlights some of the controversies therein, and suggests areas of future research to address these issues. The views expressed here are the authors own and do not represent any institution, organization or funding body.

Morgan, William F.; Bair, William J.

2013-05-01T23:59:59.000Z

354

Radiative and climate impacts of absorbing aerosols  

E-Print Network [OSTI]

V. Ramanathan (2008), Solar radiation budget and radiativeV. Ramanathan (2008), Solar radiation budget and radiativeapproximation for solar radiation in the NCAR Community

Zhu, Aihua

2010-01-01T23:59:59.000Z

355

Coherent Radiation in an Undulator  

E-Print Network [OSTI]

solving the particle-radiation system in a self-consistentto clarify the coherent radiation mechanism. References 1.the Proceedings Coherent Radiation in an Undulator Y,H. Chin

Chin, Y.H.

2011-01-01T23:59:59.000Z

356

The Properties of Undulator Radiation  

E-Print Network [OSTI]

of a Dedicated Synchrotron Radiation Facility," IEEE Trans.1983), "Characteristics of Synchrotron Radiation and of itsHandbook on Synchrotron Radiation, E. -E. Koch.1A. 65-172,

Howells, M.R.

2011-01-01T23:59:59.000Z

357

Radiation Safety (Revised March 2010)  

E-Print Network [OSTI]

Radiation Safety Manual (Revised March 2010) Updated December 2012 Stanford University, Stanford California #12; #12; Radiation Safety Manual (Revised March 2010) Updated Environmental Health and Safety, Stanford University, Stanford California #12; CREDITS This Radiation Safety

Kay, Mark A.

358

Radiation absorption properties of different plaster samples  

SciTech Connect (OSTI)

Although the plaster is one of the oldest known synthetic building materials, nowadays, it is used as interior coating of walls and ceilings of buildings. Thus measuring its radiation shielding properties is vital. For this purpose, radiation absorption properties of different plaster samples in this study. The measurements have been performed using gamma spectrometer system which connected to 3'' Multiplication-Sign 3''NaI (TI) detector.

Akkurt, Iskender; Guenoglu, Kadir; Mavi, Betuel; K Latin-Small-Letter-Dotless-I l Latin-Small-Letter-Dotless-I ncarslan, Semsettin; Seven, Aysun [Suleyman Demirel University, Faculty of Arts and Sciences, Department of Physics, Isparta (Turkey); Amasya University, Faculty of Arts and Sciences, Department of Physics, Amasya (Turkey); Suleyman Demirel University, Faculty of Technical Education, Department of Construction Education, Isparta (Turkey)

2012-09-06T23:59:59.000Z

359

[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, February 1, 1993--November 1, 1994  

SciTech Connect (OSTI)

This research focuses on two repair deficient mutations in Drosophila melanogaster, namely mei-9, mei-41. In addition, the authors propose to extend this study to include the mus-312 mutation. They expect these studies to provide substantial insights into both the molecular mechanisms of DNA repair in Drosophila and the role these genes play in normal biological processes.

Hawley, R.S.

1998-09-01T23:59:59.000Z

360

Human Ecology Study Guide 3 Summer 2008 The Third Examination will be given on July 3, 2008. The examination will be worth 100 points  

E-Print Network [OSTI]

eating and scavenging birds associated with application of DDT even though adult birds were not being atmospheric carbon dioxide act like greenhouse glass concerning absorption of solar radiation and heat being

Anderson, Roger C.

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

SYNCHROTRON RADIATION SOURCES  

SciTech Connect (OSTI)

Synchrotron radiation is a very bright, broadband, polarized, pulsed source of light extending from the infrared to the x-ray region. It is an extremely important source of Vacuum Ultraviolet radiation. Brightness is defined as flux per unit area per unit solid angle and is normally a more important quantity than flux alone particularly in throughput limited applications which include those in which monochromators are used. It is well known from classical theory of electricity and magnetism that accelerating charges emit electromagnetic radiation. In the case of synchrotron radiation, relativistic electrons are accelerated in a circular orbit and emit electromagnetic radiation in a broad spectral range. The visible portion of this spectrum was first observed on April 24, 1947 at General Electric's Schenectady facility by Floyd Haber, a machinist working with the synchrotron team, although the first theoretical predictions were by Lienard in the latter part of the 1800's. An excellent early history with references was presented by Blewett and a history covering the development of the utilization of synchrotron radiation was presented by Hartman. Synchrotron radiation covers the entire electromagnetic spectrum from the infrared region through the visible, ultraviolet, and into the x-ray region up to energies of many 10's of kilovolts. If the charged particles are of low mass, such as electrons, and if they are traveling relativistically, the emitted radiation is very intense and highly collimated, with opening angles of the order of 1 milliradian. In electron storage rings there are three possible sources of synchrotron radiation; dipole (bending) magnets; wigglers, which act like a sequence of bending magnets with alternating polarities; and undulators, which are also multi-period alternating magnet systems but in which the beam deflections are small resulting in coherent interference of the emitted light.

HULBERT,S.L.; WILLIAMS,G.P.

1998-07-01T23:59:59.000Z

362

Radiation Protection | The Ames Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation Protection Radiation Protection Regulations: The Federal Regulation governing the use of radioactive materials at Ames Laboratory is 10 CFR 835. To implement this...

363

Florida Radiation Protection Act (Florida)  

Broader source: Energy.gov [DOE]

The Department of Public Health is responsible for administering a statewide radiation protection program. The program is designed to permit development and utilization of sources of radiation for...

364

A study of ozone in the surface layer of Kiev and its impact on the human health  

E-Print Network [OSTI]

Ground-level ozone in Kiev for an episode of its high concentration in August 2000 was simulated with the model of the urban air pollution UAM-V (Urban Airshed Model). The study of total ozone over Kiev and its concentration changes with height in the troposphere is made on the basis of ground-based observations with the infrared Fourier spectrometer at the Main Astronomical Observatory of National Academy of Sciences of Ukraine as a part of the ESA-NIVR-KNMI no 2907. In 2008 the satellite Aura-OMI data OMO3PR on the atmosphere ozone profiles became available. Beginning in 2005, these data include the ozone concentration in the lower layer of the atmosphere and can be used for the evaluation of the ground-level ozone concentrations in all cities of Ukraine. Some statistical investigation of ozone air pollution in Kiev and medical statistics data on respiratory system was carried out with the application of the "Statistica" package. The regression analysis, prognostic regression simulation, and retrospective p...

Shavrina, A V; Kiforenko, S I; Sheminova, V A; Veles, A A; Blum, O B

2012-01-01T23:59:59.000Z

365

Study of air pollution: Effects of ozone on neuropeptide-mediated responses in human subjects. Final report  

SciTech Connect (OSTI)

The study examined the hypothesis that ozone inactivates the enzyme, neutral endopeptidase, responsible for limiting the effects of neuropeptides released from afferent nerve endings. Cough response of capsaicin solution delivered from a nebulizer at 2 min. intervals until two or more coughs were produced. Other endpoints measured included irritative symptoms as rated by the subjects on a nonparametric scale, spirometry, of each concentration of ozone were compared to those of filtered air in a single-blind randomized sequence. The results indicate that a 2 h. exposure to 0.4 ppm of ozone with intermittent light exercise alters the sensitivity of airway nerves that mediate the cough response to inhaled materials. This dose of ozone also caused a change in FEV1. A lower level of ozone, 0.02 ppm, caused a change in neither cough threshold nor FEV1, even when the duration of exposure was extended to three hours. The findings are consistent with the author's hypothesis that ozone may sensitize nerve endings in the airways by inactivating neutral endopeptidase, an enzyme that regulates their activity, but they do not demonstrate that directly examining an effect directly mediated by airway nerves allows detection of effects of ozone at doses below those causing effects detected by standard tests of pulmonary function.

Boushey, H.A.

1991-11-01T23:59:59.000Z

366

Composition for radiation shielding  

DOE Patents [OSTI]

A composition for use as a radiation shield. The shield has a depleted urum core for absorbing gamma rays and a bismuth coating for preventing chemical corrosion and absorbing gamma rays. Alternatively, a sheet of gadolinium may be positioned between the uranium core and the bismuth coating for absorbing neutrons. The composition is preferably in the form of a container for storing materials that emit radiation such as gamma rays and neutrons. The container is preferably formed by casting bismuth around a pre-formed uranium container having a gadolinium sheeting, and allowing the bismuth to cool. The resulting container is a structurally sound, corrosion-resistant, radiation-absorbing container.

Kronberg, James W. (Aiken, SC)

1994-01-01T23:59:59.000Z

367

Miniaturized radiation chirper  

DOE Patents [OSTI]

The disclosure relates to a miniaturized radiation chirper for use with a small battery supplying on the order of 5 volts. A poor quality CdTe crystal which is not necessarily suitable for high resolution gamma ray spectroscopy is incorporated with appropriate electronics so that the chirper emits an audible noise at a rate that is proportional to radiation exposure level. The chirper is intended to serve as a personnel radiation warning device that utilizes new and novel electronics with a novel detector, a CdTe crystal. The resultant device is much smaller and has much longer battery life than existing chirpers.

Umbarger, C. John (Los Alamos, NM); Wolf, Michael A. (Los Alamos, NM)

1980-01-01T23:59:59.000Z

368

The Intense Radiation Gas  

E-Print Network [OSTI]

We present a new dispersion relation for photons that are nonlinearly interacting with a radiation gas of arbitrary intensity due to photon-photon scattering. It is found that the photon phase velocity decreases with increasing radiation intensity, it and attains a minimum value in the limit of super-intense fields. By using Hamilton's ray equations, a self-consistent kinetic theory for interacting photons is formulated. The interaction between an electromagnetic pulse and the radiation gas is shown to produce pulse self-compression and nonlinear saturation. Implications of our new results are discussed.

M. Marklund; P. K. Shukla; B. Eliasson

2005-03-08T23:59:59.000Z

369

NEWBORN HUMAN ADULT HUMAN  

E-Print Network [OSTI]

.13998 0.92501 0.50249 0.44148 0.53202 0.00009 7.79997 0.00032 0.00839 Average Brain WEIGHT (kg) 0.11718 0.00003 Average Brain To Body Weight RatioSPECIES LABORATORY OF NEURO IMAGING, UCLA 635 Charles Young Dr. South conducts a wide variety of brain imaging studies of normal brain anatomy and function, development, aging

Leahy, Richard M.

370

An observational study of the potential for human exposures to pet-borne diazinon residues following lawn applications  

SciTech Connect (OSTI)

This study examined the potential for pet dogs to be an important pathway for transporting diazinon residues into homes and onto its occupants following residential lawn applications. The primary objectives were to investigate the potential exposures of occupants and their pet dogs to diazinon after an application to turf at their residences and to determine if personal contacts between occupants and their pet dogs resulted in measurable exposures. It was conducted from April to August 2001 before the Agency phased out all residential uses of diazinon in December 2004. Six families and their pet dogs were recruited into the study. Monitoring was conducted at pre-, 1, 2, 4, and 8 days post-application of a commercial, granular formulation of diazinon to the lawn by the homeowner. Environmental samples collected included soil, indoor air, carpet dust, and transferable residues from lawns and floors. Samples collected from the pet dogs consisted of paw wipes, fur clippings, and transferable residues from the fur by a technician or child wearing a cotton glove(s). First morning void (FMV) urine samples were collected from each child and his/her parent on each sampling day. Diazinon was analyzed in all samples, except urine, by GC-MS. The metabolite 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMPy) was analyzed in the urine samples by HPLC-MS/MS. Mean airborne residues of diazinon on day 1 post-application were at least six times higher in both the living rooms (235{+-}267 ng/m{sup 3}) and children's bedrooms (179{+-}246 ng/m{sup 3}) than at pre-application. Mean loadings of diazinon in carpet dust samples were at least 20 times greater on days 2, 4, and 8 post-application than mean loadings (0.03{+-}0.04 ng/cm{sup 2}) at pre-application. The pet dogs had over 900 times higher mean loadings of diazinon residues on their paws on day 1 post-application (88.1{+-}100.1 ng/cm{sup 2}) compared to mean loadings (<0.09 ng/cm{sup 2}) at pre-application. The mean diazinon loadings on the fur clippings were at least 14 times higher on days 1, 2, 4, and 8 post-application than mean loadings (0.8{+-}0.4 ng/cm{sup 2}) at pre-application. For transferable residues from dog fur, the mean loadings of diazinon on the technician's cotton glove samples were the lowest before application (0.04{+-}0.08 ng/cm{sup 2}) and the highest on day 1 post-application (10.4{+-}23.9 ng/cm{sup 2}) of diazinon to turf. Urinary IMPy concentrations for the participants ranged from <0.3 to 5.5 ng/mL before application and <0.3-12.5 ng/mL after application of diazinon. The mean urinary IMPy concentrations for children or adults were not statistically different (p>0.05) at pre-application compared to post-application of diazinon to turf. The results showed that the participants and their pet dogs were likely exposed to low levels of diazinon residues from several sources (i.e., air, dust, and soil), through several pathways and routes, after lawn applications at these residences. Lastly, the pet dog appears to be an important pathway for the transfer and translocation of diazinon residues inside the homes and likely exposed occupants through personal contacts (i.e., petting)

Morgan, Marsha K. [USEPA, National Exposure Research Laboratory, Research Triangle Park, NC 27709 (United States)], E-mail: morgan.marsha@epa.gov; Stout, Daniel M.; Jones, Paul A. [USEPA, National Exposure Research Laboratory, Research Triangle Park, NC 27709 (United States); Barr, Dana B. [National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA (United States)

2008-07-15T23:59:59.000Z

371

RESEARCH SAFETY RADIATION SAFETY  

E-Print Network [OSTI]

RESEARCH SAFETY RADIATION SAFETY ENVIRONMENTAL PROGRAMS HAZARDOUS MATERIALS CONTROLLED SUBSTANCES INTEGRATED WASTE MANAGEMENT LABORATORY SAFETY AUDITS & COMPLIANCE BIOSAFETY and ENVIRONMENTAL HEALTH EMERGENCY MANAGEMENT and MISSION CONTINUITY FIRE PREVENTION and LIFE SAFETY GENERAL SAFETY TRAINING

372

Amorphous silicon radiation detectors  

DOE Patents [OSTI]

Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification.

Street, Robert A. (Palo Alto, CA); Perez-Mendez, Victor (Berkeley, CA); Kaplan, Selig N. (El Cerrito, CA)

1992-01-01T23:59:59.000Z

373

Amorphous silicon radiation detectors  

DOE Patents [OSTI]

Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification. 13 figs.

Street, R.A.; Perez-Mendez, V.; Kaplan, S.N.

1992-11-17T23:59:59.000Z

374

Ionizing radiation detector  

DOE Patents [OSTI]

An ionizing radiation detector is provided which is based on the principle of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

Thacker, Louis H. (Knoxville, TN)

1990-01-01T23:59:59.000Z

375

Adaptive multigroup radiation diffusion  

E-Print Network [OSTI]

This thesis describes the development and implementation of an algorithm for dramatically increasing the accuracy and reliability of multigroup radiation diffusion simulations at low group counts. This is achieved by ...

Williams, Richard B., Sc. D. Massachusetts Institute of Technology

2005-01-01T23:59:59.000Z

376

Method of enhancing radiation response of radiation detection materials  

DOE Patents [OSTI]

The present invention is a method of increasing radiation response of a radiation detection material for a given radiation signal by first pressurizing the radiation detection material. Pressurization may be accomplished by any means including mechanical and/or hydraulic. In this application, the term "pressure" includes fluid pressure and/or mechanical stress.

Miller, Steven D. (Richland, WA)

1997-01-01T23:59:59.000Z

377

Radiation Safety Manual Dec 2012 Page 1 RADIATION SAFETY  

E-Print Network [OSTI]

Radiation Safety Manual ­ Dec 2012 Page 1 RADIATION SAFETY MANUAL For Columbia University NewYork-Presbyterian Hospital New York State Psychiatric Institute Barnard College December 2012 #12;Radiation Safety Manual ­ Dec 2012 Page 1 Table of Contents Introduction Chapter I: Radiation Safety Program A. Program

Grishok, Alla

378

Radiation Safety Training Basic Radiation Safety Training for  

E-Print Network [OSTI]

Radiation Safety Training Basic Radiation Safety Training for Sealed Source Users for Physics 461 & 462 Modern Physics Laboratory Spring 2007 #12;Radiation Safety Department, University of Tennessee Purpose: To provide basic radiation safety training to the users of sealed sources located

Dai, Pengcheng

379

Radiation Safety Training Basic Radiation Safety Training for  

E-Print Network [OSTI]

Radiation Safety Training Basic Radiation Safety Training for X-ray Users for Physics 461 & 462 Modern Physics Laboratory Spring 2007 #12;#12;Radiation Safety Department, University of Tennessee Protocol Title: Basic Radiation Safety Training for X-ray Users Drafted By: Chris Millsaps, RSS Reviewers

Dai, Pengcheng

380

SciTech Connect: Fast Monte Carlo for radiation therapy: the...  

Office of Scientific and Technical Information (OSTI)

MEDICINE, BASIC STUDIES; RADIOTHERAPY; PLANNING; COMPUTER CALCULATIONS; RADIATION DOSE DISTRIBUTIONS; MONTE CARLO METHOD; THREE-DIMENSIONAL CALCULATIONS; COMPUTERIZED TOMOGRAPHY...

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Radiation content of Conformally flat initial data  

E-Print Network [OSTI]

We study the radiation of energy and linear momentum emitted to infinity by the headon collision of binary black holes, starting from rest at a finite initial separation, in the extreme mass ratio limit. For these configurations we identify the radiation produced by the initially conformally flat choice of the three geometry. This identification suggests that the radiated energy and momentum of headon collisions will not be dominated by the details of the initial data for evolution of holes from initial proper separations $L_0\\geq7M$. For non-headon orbits, where the amount of radiation is orders of magnitude larger, the conformally flat initial data may provide a relative even better approximation.

C. O. Lousto; R. H. Price

2004-01-11T23:59:59.000Z

382

Cloud Formation and Acceleration in a Radiative Environment  

E-Print Network [OSTI]

In a radiatively heated and cooled medium, the thermal instability is a plausible mechanism for forming clouds, while the radiation force provides a natural acceleration, especially when ions recombine and opacity increases. Here we extend Field's theory to self-consistently account for a radiation force resulting from bound-free and bound-bound transitions in the optically thin limit. We present physical arguments for clouds to be significantly accelerated by a radiation force due to lines during a nonlinear phase of the instability. To qualitatively illustrate our main points, we perform both one and two-dimensional (1-D/2-D) hydrodynamical simulations that allow us to study the nonlinear outcome of the evolution of thermally unstable gas subjected to this radiation force. Our 1-D simulations demonstrate that the thermal instability can produce long-lived clouds that reach a thermal equilibrium between radiative processes and thermal conduction, while the radiation force can indeed accelerate the clouds to ...

Proga, Daniel

2015-01-01T23:59:59.000Z

383

Packet personal radiation monitor  

DOE Patents [OSTI]

A personal radiation monitor of the chirper type is provided for detecting ionizing radiation. A battery powered high voltage power supply is used to generate and apply a high voltage bias to a G-M tube radiation sensor. The high voltage is monitored by a low-loss sensing network which generates a feedback signal to control the high voltage power supply such that the high voltage bias is recharged to +500 VDC when the current pulses of the sensor, generated by the detection of ionizing radiation events, discharges the high voltage bias to +450 VDC. During the high voltage recharge period an audio transducer is activated to produce an audible "chirp". The rate of the "chirps" is controlled by the rate at which the high voltage bias is recharged, which is proportional to the radiation field intensity to which the sensor is exposed. The chirp rate sensitivity is set to be approximately 1.5 (chirps/min/MR/hr.). The G-M tube sensor is used in a current sensing mode so that the device does not paralyze in a high radiation field.

Phelps, James E. (Knoxville, TN)

1989-01-01T23:59:59.000Z

384

Radiation analysis devices, radiation analysis methods, and articles of manufacture  

DOE Patents [OSTI]

Radiation analysis devices include circuitry configured to determine respective radiation count data for a plurality of sections of an area of interest and combine the radiation count data of individual of sections to determine whether a selected radioactive material is present in the area of interest. An amount of the radiation count data for an individual section is insufficient to determine whether the selected radioactive material is present in the individual section. An article of manufacture includes media comprising programming configured to cause processing circuitry to perform processing comprising determining one or more correction factors based on a calibration of a radiation analysis device, measuring radiation received by the radiation analysis device using the one or more correction factors, and presenting information relating to an amount of radiation measured by the radiation analysis device having one of a plurality of specified radiation energy levels of a range of interest.

Roybal, Lyle Gene

2010-06-08T23:59:59.000Z

385

Balancing Human Needs and Nature Conservation: A study on the gap between design and management of the Bigi Pan Multiple-Use Management Area in Suriname, SA:.  

E-Print Network [OSTI]

??Ecosystem management has made a shift from protected area management to multiple use management area, where humans are viewed as an integral part of the (more)

Miranda, P.A.

2010-01-01T23:59:59.000Z

386

First Study of the Radiation-Amplitude Zero in W? Production and Limits on Anomalous WW? Couplings at s?=1.96??TeV  

E-Print Network [OSTI]

We present results from a study of pp-bar?W?+X events utilizing data corresponding to 0.7??fb(?1) of integrated luminosity at s?=1.96??TeV collected by the D0 detector at the Fermilab Tevatron Collider. We set limits on ...

Baringer, Philip S.; Bean, Alice; Hensel, Carsten; Moulik, Tania; Wilson, Graham Wallace; Abazov, V. M.; Abbott, B.; Abolins, M.; Acharya, B. S.

2008-06-20T23:59:59.000Z

387

DarkLight radiation backgrounds  

SciTech Connect (OSTI)

We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-on, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW CW beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, field emission inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation.

Kalantarians, N. [Department of Physics, Hampton University, Hampton VA 23668 (United States); Collaboration: DarkLight Collaboration

2013-11-07T23:59:59.000Z

388

Photon rockets and gravitational radiation  

E-Print Network [OSTI]

The absence of gravitational radiation in Kinnersley's ``photon rocket'' solution of Einstein's equations is clarified by studying the mathematically well-defined problem of point-like photon rockets in Minkowski space (i.e. massive particles emitting null fluid anisotro\\-pically and accelerating because of the recoil). We explicitly compute the (uniquely defined) {\\it linearized} retarded gravitational waves emitted by such objects, which are the coherent superposition of the gravitational waves generated by the motion of the massive point-like rocket and of those generated by the energy-momentum distribution of the photon fluid. In the special case (corresponding to Kinnersley's solution) where the anisotropy of the photon emission is purely dipolar we find that the gravitational wave amplitude generated by the energy-momentum of the photons exactly cancels the usual $1/r$ gravitational wave amplitude generated by the accelerated motion of the rocket. More general photon anisotropies would, however, generate genuine gravitational radiation at infinity. Our explicit calculations show the compatibility between the non-radiative character of Kinnersley's solution and the currently used gravitational wave generation formalisms based on post-Minkowskian perturbation theory.

T. Damour

1994-12-21T23:59:59.000Z

389

ADAPTIVE RADIATION ROSEMARY G. GILLESPIE  

E-Print Network [OSTI]

1 A ADAPTIVE RADIATION ROSEMARY G. GILLESPIE University of California, Berkeley Adaptive radiation- tions and convergence of species groups on different land masses. Since then, adaptive radiation has diversity within a rapidly multiplying lineage." There are radiations that are not adaptive

Gillespie, Rosemary

390

REPORT NO. 8 radiation hazards  

E-Print Network [OSTI]

REPORT NO. 8 REVISED guidance for the control of radiation hazards in uranium mining SEPTEMBER 1967 OF RADIATION HAZARDS IN URANIUM MINING SEPTEMBER 1967 Staff Report of the FEDERAL RADIATION COUNCIL #12;FEDERAL...... .... .._ _.... Section I. Introduction. . . Section II. The Radiation Environment AssociatedWith Uranium Mining. Section

391

Radiation delivery system and method  

DOE Patents [OSTI]

A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

2002-01-01T23:59:59.000Z

392

Radiation Research Department Paper: www.risoe.dk/rispubl/art/2007_333.pdf  

E-Print Network [OSTI]

and released to the environment by human nuclear activity, including nuclear weapons testing, operation of Radionuclides in Environmental, Biological and Nuclear Waste Samples Xiaolin Hou and Per Roos Radiation Research in Environmental, Biological and Nuclear Waste Samples Xiaolin Hou* Per Roos Radiation Research Department, Risø

393

Packet personal radiation monitor  

DOE Patents [OSTI]

A personal radiation monitor of the chirper type is provided for detecting ionizing radiation. A battery powered high voltage power supply is used to generate and apply a high voltage bias to a G-M tube radiation sensor. The high voltage is monitored by a low-loss sensing network which generates a feedback signal to control the high voltage power supply such that the high voltage bias is recharged to +500 VDC when the current pulses of the sensor, generated by the detection of ionizing radiatonevents, discharges the high voltage bias to +450 VDC. During the high voltage recharge period an audio transducer is activated to produce an audible ''chirp''. The rate of the ''chirps'' is controlled by the rate at which the high voltage bias is recharged, which is proportional to the radiation field intensity to which the sensor is exposed. The chirp rate sensitivity is set to be approximately 1.5 (chirps/min/MR/hr.). The G-M tube sensor is used in a current sensing mode so that the device does not paralyze in a high radiation field. 2 figs.

Phelps, J.E.

1988-03-31T23:59:59.000Z

394

Remote radiation dosimetry  

DOE Patents [OSTI]

Disclosed are methods and apparatus for remotely measuring radiation levels. Such are particularly useful for measuring relatively high levels or dosages of radiation being administered in radiation therapy. They are also useful for more general radiation level measurements where remote sensing from the remaining portions of the apparatus is desirable. The apparatus uses a beam generator, such as a laser beam, to provide a stimulating beam. The stimulating beam is preferably of wavelengths shorter than 6 microns, or more advantageously less than 2 microns. The stimulating beam is used to stimulate a remote luminescent sensor mounted in a probe which emits stored luminescent energy resulting from exposure of the sensor to ionizing radiation. The stimulating beam is communicated to the remote luminescent sensor via a transmissive fiber which also preferably serves to return the emission from the luminescent sensor. The stimulating beam is advantageously split by a beam splitter to create a detector beam which is measured for power during a reading period during which the luminescent phosphor is read. The detected power is preferably used to control the beam generator to thus produce desired beam power during the reading period. The luminescent emission from the remote sensor is communicated to a suitable emission detector, preferably after filtering or other selective treatment to better isolate the luminescent emission. 8 figures.

Braunlich, P.F.; Tetzlaff, W.; Hegland, J.E.; Jones, S.C.

1991-03-12T23:59:59.000Z

395

Development of EPA radiation site cleanup regulations  

SciTech Connect (OSTI)

This paper summarizes the EPA program to develop radiation site cleanup and identifies many of the issues related to that effort. The material is drawn from portions of the Agency`s Issues Paper on Radiation Site Cleanup Regulations (EPA 402-R-93-084). The site cleanup regulations will be designed to protect human health and the environment and to facilitate the cleanup of sites. EPA believes that developing specific cleanup standards for radionuclides will ensure consistent, protective, and cost-effective site remediation. They will apply to all Federal facilities such as those operated by the US Department of Energy (DOE), the US Department of Defense (DoD), and sites licensed by the US Nuclear Regulatory Commission (NRC) and its Agreement States.

Burnett, J.

1994-12-31T23:59:59.000Z

396

Cerenkov radiation from moving straight strings  

E-Print Network [OSTI]

We study Cerenkov radiation from moving straight strings which glisse with respect to each other in such a way that the projected intersection point moves faster than light. To calculate this effect we develop classical perturbation theory for the system of Nambu-Goto strings interacting with dilaton, two-form and gravity. In the first order one encounters divergent self-action terms which are eliminated by classical renormalization of the string tension. Cerenkov radiation arises in the second order. It is generated by an effective source which contains contributions localized on the strings world-sheets and bulk contributions quadratic in the first order fields. In the ultra-relativistic limit radiation exhibits angular peaking on the Cerenkov cone in the forward direction of the fast string in the rest frame of another. The radiation spectrum then extends up to high frequencies proportional to square of the Lorentz-factor of the relative velocity. Gravitational radiation is absent since the 1+2 space-time transverse to the straight string does not allow for gravitons. A rough estimate of the Cerenkov radiation in the cosmological cosmic strings network is presented.

D. V. Gal'tsov; E. Yu. Melkumova; K. Salehi

2006-12-30T23:59:59.000Z

397

Photochemical Internalization of Bleomycin Before External-Beam Radiotherapy Improves Locoregional Control in a Human Sarcoma Model  

SciTech Connect (OSTI)

Purpose: The aim of this study was to explore the tumor growth response of the combination photochemical internalization and external-beam radiotherapy. Photochemical internalization is a technology to improve the utilization of therapeutic macromolecules in cancer therapy by photochemical release of endocytosed macromolecules into the cytosol. Methods and Materials: A human sarcoma xenograft TAX-1 was inoculated subcutaneously into nude mice. The photosensitizer AlPcS{sub 2a} and bleomycin were intraperitoneally administrated 48 h and 30 min, respectively, before diode laser light exposure at 670 nm (20 J/cm{sup 2}). Thirty minutes or 7 days after photochemical treatment, the animals were subjected to 4 Gy of ionizing radiation. Results: Using photochemical internalization of bleomycin as an adjunct to ionizing radiation increased the time to progression for the tumors from 17 to 33 days as compared with that observed with photodynamic therapy combined with ionizing radiation as well as for radiochemotherapy with bleomycin. The side effects observed when photochemical internalization of bleomycin was given shortly before ionizing radiation were eliminated by separating the treatment modalities in time. Conclusion: Photochemical internalization of bleomycin combined with ionizing radiation increased the time to progression and showed minimal toxicity and may therefore reduce the total radiation dose necessary to obtain local tumor control while avoiding long-term sequelae from radiotherapy.

Norum, Ole-Jacob, E-mail: oleno@radiumhospitalet.n [Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Department of Surgical Oncology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Bruland, Oyvind Sverre [Department of Oncology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Faculty of Clinical Medicine, University of Oslo, Oslo (Norway); Gorunova, Ludmila [Department of Medical Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway); Berg, Kristian [Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo (Norway)

2009-11-01T23:59:59.000Z

398

Semiconductor radiation detector  

DOE Patents [OSTI]

A semiconductor detector for ionizing electromagnetic radiation, neutrons, and energetic charged particles. The detecting element is comprised of a compound having the composition I-III-VI.sub.2 or II-IV-V.sub.2 where the "I" component is from column 1A or 1B of the periodic table, the "II" component is from column 2B, the "III" component is from column 3A, the "IV" component is from column 4A, the "V" component is from column 5A, and the "VI" component is from column 6A. The detecting element detects ionizing radiation by generating a signal proportional to the energy deposited in the element, and detects neutrons by virtue of the ionizing radiation emitted by one or more of the constituent materials subsequent to capture. The detector may contain more than one neutron-sensitive component.

Bell, Zane W. (Oak Ridge, TN); Burger, Arnold (Knoxville, TN)

2010-03-30T23:59:59.000Z

399

Composition for radiation shielding  

DOE Patents [OSTI]

A composition for use as a radiation shield is disclosed. The shield has a depleted uranium core for absorbing gamma rays and a bismuth coating for preventing chemical corrosion and absorbing gamma rays. Alternatively, a sheet of gadolinium may be positioned between the uranium core and the bismuth coating for absorbing neutrons. The composition is preferably in the form of a container for storing materials that emit radiation such as gamma rays and neutrons. The container is preferably formed by casting bismuth around a pre-formed uranium container having a gadolinium sheeting, and allowing the bismuth to cool. The resulting container is a structurally sound, corrosion-resistant, radiation-absorbing container. 2 figs.

Kronberg, J.W.

1994-08-02T23:59:59.000Z

400

Human Ecology Human ecology Research  

E-Print Network [OSTI]

Channel, Latin America. STUDIOS Architecture. #12;HUMAN ECOLOGY · APRIL 2005 1 Lisa Staiano-Coico, Ph Frey spins a green alternative for textiles. Fibers from rapidly renewable materials

Wang, Z. Jane

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Motion-induced radiation from electrons moving in Maxwell's fish-eye  

E-Print Network [OSTI]

In \\u{C}erenkov radiation and transition radiation, evanescent wave from motion of charged particles transfers into radiation coherently. However, such dissipative motion-induced radiations require particles to move faster than light in medium or to encounter velocity transition to pump energy. Inspired by a method to detect cloak by observing radiation of a fast-moving electron bunch going through it by Zhang {\\itshape et al.}, we study the generation of electron-induced radiation from electrons' interaction with Maxwell's fish-eye sphere. Our calculation shows that the radiation is due to a combination of \\u{C}erenkov radiation and transition radiation, which may pave the way to investigate new schemes of transferring evanescent wave to radiation.

Liu, Yangjie

2013-01-01T23:59:59.000Z

402

Tunable terahertz radiation source  

SciTech Connect (OSTI)

Terahertz radiation source and method of producing terahertz radiation, said source comprising a junction stack, said junction stack comprising a crystalline material comprising a plurality of self-synchronized intrinsic Josephson junctions; an electrically conductive material in contact with two opposing sides of said crystalline material; and a substrate layer disposed upon at least a portion of both the crystalline material and the electrically-conductive material, wherein the crystalline material has a c-axis which is parallel to the substrate layer, and wherein the source emits at least 1 mW of power.

Boulaevskii, Lev; Feldmann, David M; Jia, Quanxi; Koshelev, Alexei; Moody, Nathan A

2014-01-21T23:59:59.000Z

403

Wireless passive radiation sensor  

DOE Patents [OSTI]

A novel measurement technique is employed using surface acoustic wave (SAW) devices, passive RF, and radiation-sensitive films to provide a wireless passive radiation sensor that requires no batteries, outside wiring, or regular maintenance. The sensor is small (<1 cm.sup.2), physically robust, and will operate unattended for decades. In addition, the sensor can be insensitive to measurement position and read distance due to a novel self-referencing technique eliminating the need to measure absolute responses that are dependent on RF transmitter location and power.

Pfeifer, Kent B; Rumpf, Arthur N; Yelton, William G; Limmer, Steven J

2013-12-03T23:59:59.000Z

404

High-resolution structural studies of ultra-thin magnetic, transition metal overlayers and two-dimensional transition metal oxides using synchrotron radiation  

SciTech Connect (OSTI)

This thesis report the surface-structure determination of three, ultra-thin magnetic transition-metal films, Fe/Au(100), Mn/Ni(100), and Mn/Cu(100) using Angle-Resolved Photoemission Extended Fine Structure (ARPEFS) and photoelectron holography. These structural studies are the first to use non-s initial states in the ARPEFS procedure. This thesis also reports an ARPEFS surface-structure determination of a two-dimensional transition-metal oxide, [(1 x 1)O/W(110)] x 12. The authors have analyzed the ARPFES signal from the Au 4f{sub 7/5} core level of the Au(1 ML)/Fe(15 ML)/Au(100) system. The analysis shows that the Fe grows layer by layer with one monolayer of gold, acting as a surfactant, remaining on top of the growing Fe layers. These surface gold atoms sit in the four-fold hollow site, 1.67 {+-} 0.02 A above the iron surface. The grown Fe layer is very much like the bulk, bcc iron, with an interlayer spacing of 1.43 {+-} 0.03 A. Analysis of the Mn 3p ARPEFS signals from c(2 x 2)Mn/Ni(100) and c(2 x 2)Mn/Cu(100) shows that the Mn forms highly corrugated surface alloys. The corrugation of the Mn/Ni(100) and Mn/Cu(100) systems are 0.24 {+-} 0.02 A and 0.30 {+-} 0.04 A respectively. In both cases the Mn is sticking above the plane of the surface substrate atoms. For the Mn/Ni(100) system the first layer Ni is contracted 4% from the bulk value. The Mn/Cu(100) system shows bulk spacing for the substrate Cu. Photoelectron holography shows that the Mn/Ni interface is very abrupt with very little Mn leaking into the second layer, while the Mn/Cu(100) case has a significant amount of Mn leaking into the second layer. A new, five-element electrostatic electron lens was developed for hemispherical electron-energy analyzers. This lens system can be operated at constant transverse or constants angular magnification, and has been optimized for use with the very small photon-spot sizes. Improvements to the hemispherical electron-energy analyzer are also discussed.

Kellar, S.A. [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry; [Lawrence Berkeley National Lab., CA (United States). Advanced Light Source Div.

1997-05-01T23:59:59.000Z

405

A study of the necessary and optimal conditions for success in the most challenging human endeavors : modem day Manhattan Projects are needed for overcoming contemporary global challenges  

E-Print Network [OSTI]

It is possible to categorize four contemporary challenges as the greatest threats to global well-being and the persistence of humankind. These challenges are global climate and ecological change, poor human health management, ...

Chowdhury, Anando A

2012-01-01T23:59:59.000Z

406

Unruh radiation and Interference effect  

E-Print Network [OSTI]

A uniformly accelerated charged particle feels the vacuum as thermally excited and fluctuates around the classical trajectory. Then we may expect additional radiation besides the Larmor radiation. It is called Unruh radiation. In this report, we review the calculation of the Unruh radiation with an emphasis on the interference effect between the vacuum fluctuation and the radiation from the fluctuating motion. Our calculation is based on a stochastic treatment of the particle under a uniform acceleration. The basics of the stochastic equation are reviewed in another report in the same proceeding. In this report, we mainly discuss the radiation and the interference effect.

Satoshi Iso; Yasuhiro Yamamoto; Sen Zhang

2011-02-23T23:59:59.000Z

407

Logic and t h e Study of Human Reasoning 1.1 Why were psychologists i n t e r e s t e d i n deductive l o g i c ?  

E-Print Network [OSTI]

Chapter 1 Logic and t h e Study of Human Reasoning 1.1 Why were psychologists i n t e r e s t e d i hypotheses. -- Jerome Bruner* For many, the degree t o which human l e a r n i n g mechanisms can be counted on t o produce v a l i d knowledge is t h e measure of man's r a t i o n a l i t y . But what c h a r a c

Cosmides, Leda

408

Cytogenetic study of population three years after the Chernobyl disaster  

SciTech Connect (OSTI)

Studies after the Chernobyl Disaster revealed an increased level of chromosome aberrations in cultured lymphocytes of the inhabitants of the radiation-polluted regions. This work estimates the resolution capacity of a method of accounting for chromosomal aberrations in human lymphocyte culture. The results reveal population effects of low-dose chronic irradiation by radioactive sediments three and more years after the Chernobyl Disaster. 13 refs., 2 tabs.

Bochkov, N.P.; Katosova, L.D.; Platonova, V.I. [Research Center for Medical Genetics, Moscow (Russian Federation)] [and others

1995-11-01T23:59:59.000Z

409

Unilateral radiation pneumonitis in sheep: Physiological changes and bronchoalveolar lavage  

SciTech Connect (OSTI)

Radiation pneumonitis is a life-threatening result of therapeutic thoracic irradiation, yet its mechanisms are poorly understood. We studied the effects of unilateral lung irradiation (3,000 rad) in sheep from the immediate response to the later development of radiation pneumonitis. We defined radiation pneumonitis by its diagnostic clinical feature, radiographic infiltration of the irradiated zone with a straight margin corresponding to the radiation port. The immediate response in the few hours after irradiation was characterized by cough, labored respiration, hypoxemia (arterial PO{sub 2} decreased 19 Torr), mild pulmonary hypertension (pulmonary arterial pressure increased 20%), and lymphopenia. Hemodynamics and gas exchange returned to normal by day 2 but became abnormal again before or during radiation pneumonitis at 32 +/- 2 days. Respiratory distress, hypoxemia, and pulmonary hypertension recurred during radiation pneumonitis. Bronchoalveolar lavage during radiation pneumonitis contained increased neutrophils (19 +/- 4%, control = 7%), increased protein (0.27 +/- 0.1 g/dl, control = 0.12 +/- 0.03), and severely impaired ability to lower surface tension. Alveolar macrophages from both lungs during unilateral radiation pneumonitis exhibited impaired generation of superoxide after phorbol myristate (only a 30% increase). Normal control alveolar macrophages increased superoxide production after stimulation greater than 400%. We conclude that unilateral lung irradiation in sheep causes a mild immediate response followed by radiation pneumonitis at 1 mo. Unilateral radiation pneumonitis in this model is associated with ipsilateral neutrophilic alveolitis, increased bronchoalveolar lavage protein, and impaired surfactant function, as well as bilateral functional abnormalities of alveolar macrophages.

Tillman, B.F.; Loyd, J.E.; Malcolm, A.W.; Holm, B.A.; Brigham, K.L. (Vanderbilt Univ. School of Medicine, Nashville, TN (USA))

1989-03-01T23:59:59.000Z

410

Evaluation of Arctic Broadband Surface Radiation Measurements  

SciTech Connect (OSTI)

The Arctic is a challenging environment for making in-situ radiation measurements. A standard suite of radiation sensors is typically designed to measure the total, direct and diffuse components of incoming and outgoing broadband shortwave (SW) and broadband thermal infrared, or longwave (LW) radiation. Enhancements can include various sensors for measuring irradiance in various narrower bandwidths. Many solar radiation/thermal infrared flux sensors utilize protective glass domes and some are mounted on complex mechanical platforms (solar trackers) that rotate sensors and shading devices that track the sun. High quality measurements require striking a balance between locating sensors in a pristine undisturbed location free of artificial blockage (such as buildings and towers) and providing accessibility to allow operators to clean and maintain the instruments. Three significant sources of erroneous data include solar tracker malfunctions, rime/frost/snow deposition on the instruments and operational problems due to limited operator access in extreme weather conditions. In this study, a comparison is made between the global and component sum (direct [vertical component] + diffuse) shortwave measurements. The difference between these two quantities (that theoretically should be zero) is used to illustrate the magnitude and seasonality of radiation flux measurement problems. The problem of rime/frost/snow deposition is investigated in more detail for one case study utilizing both shortwave and longwave measurements. Solutions to these operational problems are proposed that utilize measurement redundancy, more sophisticated heating and ventilation strategies and a more systematic program of operational support and subsequent data quality protocols.

Matsui, N.; Long, Charles N.; Augustine, J. A.; Halliwell, D.; Uttal, Taneil; Longenecker, D.; Niebergale, J.; Wendell, J.; Albee, R.

2012-02-24T23:59:59.000Z

411

Psoriasis and ultraviolet radiation  

SciTech Connect (OSTI)

Prevention and detection screening programs as a public health service in curtailing the ever-increasing incidence of all forms of skin cancer are reviewed. The effect of solar and artificial ultraviolet radiation on the general population and persons with psoriasis is examined. 54 refs.

Farber, E.M.; Nall, L. (Psoriasis Research Institute, Palo Alto, CA (United States))

1993-09-01T23:59:59.000Z

412

Thermostatic Radiator Valve Evaluation  

SciTech Connect (OSTI)

A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market.

Dentz, Jordan [Advanced Residential Integrated Energy Solutions Collaborative, New York, NY (United States); Ansanelli, Eric [Advanced Residential Integrated Energy Solutions Collaborative, New York, NY (United States)

2015-01-01T23:59:59.000Z

413

Radiation Source Replacement Workshop  

SciTech Connect (OSTI)

This report summarizes a Radiation Source Replacement Workshop in Houston Texas on October 27-28, 2010, which provided a forum for industry and researchers to exchange information and to discuss the issues relating to replacement of AmBe, and potentially other isotope sources used in well logging.

Griffin, Jeffrey W.; Moran, Traci L.; Bond, Leonard J.

2010-12-01T23:59:59.000Z

414

Photovoltaic radiation detector element  

DOE Patents [OSTI]

A radiation detector element is formed of a body of semiconductor material, a coating on the body which forms a photovoltaic junction therewith, and a current collector consisting of narrow metallic strips, the aforesaid coating having an opening therein in the edge of which closely approaches but is spaced from the current collector strips.

Agouridis, D.C.

1980-12-17T23:59:59.000Z

415

Local microwave background radiation  

E-Print Network [OSTI]

An inquiry on a possible local origin for the Microwave Background Radiation is made. Thermal MBR photons are contained in a system called {\\it magnetic bottle} which is due to Earth magnetic field and solar wind particles, mostly electrons. Observational tests are anticipated.

Domingos Soares

2014-11-13T23:59:59.000Z

416

Radiation detector spectrum simulator  

DOE Patents [OSTI]

A small battery operated nuclear spectrum simulator having a noise source nerates pulses with a Gaussian distribution of amplitudes. A switched dc bias circuit cooperating therewith generates several nominal amplitudes of such pulses and a spectral distribution of pulses that closely simulates the spectrum produced by a radiation source such as Americium 241.

Wolf, Michael A. (Los Alamos, NM); Crowell, John M. (Los Alamos, NM)

1987-01-01T23:59:59.000Z

417

Radiation Dose Estimates from  

E-Print Network [OSTI]

Summary: Radiation Dose Estimates from Hanford Radioactive Material Releases to the Air and the Columbia River April 21,1994 TheTechnid Steering Panel of the Hanford - Environmental Dose Reconstruction than 40years, the U.S. Government made plutonium for nuclear weapons at the Hanford

418

Radiation detector spectrum simulator  

DOE Patents [OSTI]

A small battery operated nuclear spectrum simulator having a noise source generates pulses with a Gaussian distribution of amplitudes. A switched dc bias circuit cooperating therewith to generate several nominal amplitudes of such pulses and a spectral distribution of pulses that closely simulates the spectrum produced by a radiation source such as Americium 241.

Wolf, M.A.; Crowell, J.M.

1985-04-09T23:59:59.000Z

419

RADIATION ALERT User Manual  

E-Print Network [OSTI]

Environmental Area Monitoring 16 Checking for Surface Contamination 16 5 Maintenance 17 Calibration 17 Monitoring possible radiation exposure while working with radionuclides Screening for environmental. Water can damage the circuitry and the mica surface of the Geiger tube. Do not put the Inspector

Haller, Gary L.

420

Monte Carlo simulations of solid walled proportional counters with different site size for HZE radiation  

E-Print Network [OSTI]

Characterizing high z high energy (HZE) particles in cosmic radiation is of importance for the study of the equivalent dose to astronauts. Low pressure, tissue equivalent proportional counters (TEPC) are routinely used to evaluate radiation...

Wang, Xudong

2009-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Modeling radiation-induced mixing at interfaces between low solubility metals  

E-Print Network [OSTI]

This thesis studies radiation-induced mixing at interfaces between low solubility metals using molecular dynamics (MD) computer simulations. It provides original contributions on the fundamental mechanisms of radiation-induced ...

Zhang, Liang, Ph. D. Massachusetts Institute of Technology

2014-01-01T23:59:59.000Z

422

E-Print Network 3.0 - antibody-targeted radiation cancer Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is an increased risk of cancer. The amount of risk depends on the amount of radiation dose... low-level radiation exposure increases one's risk of cancer, medical studies have...

423

NREL Solar Radiation Resource Assessment Project: Status and outlook  

SciTech Connect (OSTI)

This report summarizes the activities and accomplishments of NREL's Solar Radiation Resource Assessment Project during fiscal year 1991. Currently, the primary focus of the SRRAP is to produce a 1961--1990 National Solar Radiation Data Base, providing hourly values of global horizontal, diffuse, and direct normal solar radiation at approximately 250 sites around the United States. Because these solar radiation quantities have been measured intermittently at only about 50 of these sites, models were developed and applied to the majority of the stations to provide estimates of these parameters. Although approximately 93% of the data base consists of modeled data this represents a significant improvement over the SOLMET/ERSATZ 1952--1975 data base. The magnitude and importance of this activity are such that the majority of SRRAP human and financial in many other activities, which are reported here. These include the continued maintenance of a solar radiation monitoring network in the southeast United States at six Historically Black Colleges and Universities (HBCU's), the transfer of solar radiation resource assessment technology through a variety of activities, participation in international programs, and the maintenance and operation of NREL's Solar Radiation Research Laboratory. 17 refs.

Renne, D.; Riordan, C.; Maxwell, E.; Stoffel, T.; Marion, B.; Rymes, M.; Wilcox, S.; Myers, D.

1992-05-01T23:59:59.000Z

424

ACS WFC CCD Radiation Test: The Radiation Environment  

E-Print Network [OSTI]

of external surfaces by naturally occurring atomic oxygen. CCD detectors are particularly vulnerable to damage damage. A comprehensive discussion of the types of radiation damage known to occur in CCDs is beyond1 ACS WFC CCD Radiation Test: The Radiation Environment Michael R. Jones Space Telescope Science

Sirianni, Marco

425

Betatron radiation from density tailored plasmas  

E-Print Network [OSTI]

Betatron radiation from density tailored plasmas K. Tathe resulting betatron radiation spectrum can therefore bepro?le, the betatron radiation emitted by theses electrons

Ta Phuoc, Kim

2010-01-01T23:59:59.000Z

426

Nanoscale Engineering Of Radiation Tolerant Silicon Carbide....  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering Of Radiation Tolerant Silicon Carbide. Nanoscale Engineering Of Radiation Tolerant Silicon Carbide. Abstract: Radiation tolerance is determined by how effectively the...

427

Radiative interactions: I. Light scattering and emission from irregular particles. II. Time dependent radiative coupling of an atmosphere-ocean system  

E-Print Network [OSTI]

and fluorescence. In the second part of the dissertation, we study radiative interactions in an atmosphere-ocean system. By using the so called Matrix operator method, not only the radiance of the radiation field, but also the polarization of the radiation field...

Li, Changhui

2006-10-30T23:59:59.000Z

428

Health Physicist (Radiation Protection Specialist)  

Broader source: Energy.gov [DOE]

A successful candidate in this position will serve as the Health Physicist (Radiation Protection Specialist) senior subject matter expert for health physics/radiation safety at the sites. You will...

429

Acceleration and Classical Electromagnetic Radiation  

E-Print Network [OSTI]

Classical radiation from an accelerated charge is reviewed along with the reciprocal topic of accelerated observers detecting radiation from a static charge. This review commemerates Bahram Mashhoon's 60th birthday.

E. N. Glass

2008-01-09T23:59:59.000Z

430

Pacific Northwest Solar Radiation Data  

E-Print Network [OSTI]

Pacific Northwest Solar Radiation Data UO SOLAR MONITORING LAB Physics Department -- Solar Energy Center 1274 University of Oregon Eugene, Oregon 97403-1274 April 1, 1999 #12;Hourly solar radiation data

Oregon, University of

431

ELECTROMAGNETIC RADIATION FROM A STRONG DC ELECTRIC FIELD  

E-Print Network [OSTI]

ELECTROMAGNETIC RADIATION FROM A STRONG DC ELECTRIC FIELD Manuel Gudel 1 and Donat G. Wentzel 2 1 accelerated by a strong dc electric field show not only very efficient generation of beam waves but also emission of omode radiation. We present a set of particle simulations for which we study the behavior

Guedel, Manuel

432

DOE Radiation Records Contacts List  

Broader source: Energy.gov [DOE]

DOE radiation records contact list for individuals to obtain records of occupational exposure directly from a DOE site.

433

Gamma radiation field intensity meter  

DOE Patents [OSTI]

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

Thacker, L.H.

1995-10-17T23:59:59.000Z

434

Gamma radiation field intensity meter  

DOE Patents [OSTI]

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

Thacker, L.H.

1994-08-16T23:59:59.000Z

435

Gamma radiation field intensity meter  

DOE Patents [OSTI]

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

Thacker, Louis H. (Knoxville, TN)

1995-01-01T23:59:59.000Z

436

Gamma radiation field intensity meter  

DOE Patents [OSTI]

A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

Thacker, Louis H. (Knoxville, TN)

1994-01-01T23:59:59.000Z

437

Carbonaceous Aerosols and Radiative Effects Study  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation Sites Proposed RouteNanotube TemplatedStorage Medium to

438

Functional genomics as a window on radiation stress signaling Sally A Amundson*,1  

E-Print Network [OSTI]

Functional genomics as a window on radiation stress signaling Sally A Amundson*,1 , Michael Bittner 20892, USA; 2 National Human Genome Research Institute, National Institutes of Health, Bethesda, MD before the completion of the human genome draft sequence, a number of techniques for genomic expression

439

Multiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation Response Effects of Radiation Quality and HypoxiaEffects of Radiation Quality and Hypoxia  

E-Print Network [OSTI]

Multiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation ResponseMultiscale Modeling of Radiation Response Effects of Radiation Quality and HypoxiaEffects of Radiation Quality and Hypoxia Robert D. Stewart, Ph.D.Robert D. Stewart, Ph

Stewart, Robert D.

440

Radiation Protection Guidance Hospital Staff  

E-Print Network [OSTI]

Page 1 Radiation Protection Guidance For Hospital Staff Prepared for Stanford The privilege to use ionizing radiation at Stanford University, Stanford Hospital and Clinics, Lucile Packard with radioactive materials or radiation devices are responsible for knowing and adhering to applicable requirements

Kay, Mark A.

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

COLUMBIA UNIVERSITY Radiation Safety Program  

E-Print Network [OSTI]

COLUMBIA UNIVERSITY Radiation Safety Program Medical Center - T: 212-305-0303 F: 212-305-0318 rso-clinical@columbia by more than 50 percent. #12;COLUMBIA UNIVERSITY Radiation Safety Program Medical Center - T: 212 ________________________________________________________ ________________________________________________________ #12;COLUMBIA UNIVERSITY Radiation Safety Program Medical Center - T: 212-305-0303 F: 212-305-0318 rso-clinical@columbia

Jia, Songtao

442

Debris Disk Radiative Transfer Simulation Tool (DDS)  

E-Print Network [OSTI]

A WWW interface for the simulation of spectral energy distributions of optically thin dust configurations with an embedded radiative source is presented. The density distribution, radiative source, and dust parameters can be selected either from an internal database or defined by the user. This tool is optimized for studying circumstellar debris disks where large grains are expected to determine the far-infrared through millimeter dust reemission spectral energy distribution. The tool is available at http://aida28.mpia-hd.mpg.de/~swolf/dds

S. Wolf; L. A. Hillenbrand

2005-06-17T23:59:59.000Z

443

Scattering of radiation in collisionless dusty plasmas  

SciTech Connect (OSTI)

Scattering of electromagnetic waves in collisionless dusty plasmas is studied in the framework of a multi-component kinetic model. The investigation focuses on the spectral distribution of the scattered radiation. Pronounced dust signatures are identified in the coherent spectrum due to scattering from the shielding cloud around the dust grains, dust acoustic waves, and dust-ion acoustic waves. The magnitude and shape of the scattered signal near these spectral regions are determined with the aid of analytical expressions and its dependence on the dust parameters is investigated. The use of radiation scattering as a potential diagnostic tool for dust detection is discussed.

Tolias, P.; Ratynskaia, S. [Space and Plasma Physics, Royal Institute of Technology, Stockholm SE-100 44 (Sweden)

2013-04-15T23:59:59.000Z

444

Scattering by an electromagnetic radiation field  

E-Print Network [OSTI]

Motion of test particles in the gravitational field associated with an electromagnetic plane wave is investigated. The interaction with the radiation field is modeled by a force term {\\it \\`a la} Poynting-Robertson entering the equations of motion given by the 4-momentum density of radiation observed in the particle's rest frame with a multiplicative constant factor expressing the strength of the interaction itself. Explicit analytical solutions are obtained. Scattering of fields by the electromagnetic wave, i.e., scalar (spin 0), massless spin $\\frac12$ and electromagnetic (spin 1) fields, is studied too.

Donato Bini; Andrea Geralico

2014-08-21T23:59:59.000Z

445

Radiation Damage in Polarized Ammonia Solids  

E-Print Network [OSTI]

Solid NH3 and ND3 provide a highly polarizable, radiation resistant source of polarized protons and deuterons and have been used extensively in high luminosity experiments investigating the spin structure of the nucleon. Over the past twenty years, the UVA polarized target group has been instrumental in producing and polarizing much of the material used in these studies, and many practical considerations have been learned in this time. In this discussion, we analyze the polarization performance of the solid ammonia targets used during the recent JLab Eg4 run. Topics include the rate of polarization decay with accumulated charge, the annealing procedure for radiation damaged targets to recover polarization, and the radiation induced change in optimum microwave frequency used to polarize the sample. We also discuss the success we have had in implementing frequency modulation of the polarizing microwave frequency.

K. Slifer

2007-11-28T23:59:59.000Z

446

Electric Dipole Radiation from Spinning Dust Grains  

E-Print Network [OSTI]

We discuss the rotational excitation of small interstellar grains and the resulting electric dipole radiation from spinning dust. Attention is given to excitation and damping of rotation by: collisions with neutrals; collisions with ions; plasma drag; emission of infrared radiation; emission of microwave radiation; photoelectric emission; and formation of H_2 on the grain surface. We introduce dimensionless functions F and G which allow direct comparison of the contributions of different mechanisms to rotational drag and excitation. Emissivities are estimated for dust in different phases of the interstellar medium, including diffuse HI, warm HI, low-density photoionized gas, and cold molecular gas. Spinning dust grains can explain much, and perhaps all, of the 14-50 GHz background component recently observed in CBR studies. It should be possible to detect rotational emission from small grains by ground-based observations of molecular clouds.

B. T. Draine; A. Lazarian

1998-02-18T23:59:59.000Z

447

Terahertz radiation mixer  

DOE Patents [OSTI]

A terahertz radiation mixer comprises a heterodyned field-effect transistor (FET) having a high electron mobility heterostructure that provides a gatable two-dimensional electron gas in the channel region of the FET. The mixer can operate in either a broadband pinch-off mode or a narrowband resonant plasmon mode by changing a grating gate bias of the FET. The mixer can beat an RF signal frequency against a local oscillator frequency to generate an intermediate frequency difference signal in the microwave region. The mixer can have a low local oscillator power requirement and a large intermediate frequency bandwidth. The terahertz radiation mixer is particularly useful for terahertz applications requiring high resolution.

Wanke, Michael C. (Albuquerque, NM); Allen, S. James (Santa Barbara, CA); Lee, Mark (Albuquerque, NM)

2008-05-20T23:59:59.000Z

448

Radiation shielding composition  

DOE Patents [OSTI]

A composition for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm.sup.3 and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile.

Quapp, William J. (Idaho Falls, ID); Lessing, Paul A. (Idaho Falls, ID)

2000-12-26T23:59:59.000Z

449

Radiation shielding composition  

DOE Patents [OSTI]

A composition for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm.sup.3 and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile.

Quapp, William J. (Idaho Falls, ID); Lessing, Paul A. (Idaho Falls, ID)

1998-01-01T23:59:59.000Z

450

Radiation shielding composition  

DOE Patents [OSTI]

A composition is disclosed for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm{sup 3} and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile. 5 figs.

Quapp, W.J.; Lessing, P.A.

1998-07-28T23:59:59.000Z

451

Time encoded radiation imaging  

DOE Patents [OSTI]

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21T23:59:59.000Z

452

National Ambient Radiation Database  

SciTech Connect (OSTI)

The U.S. Environmental Protection Agency (EPA) recently developed a searchable database and website for the Environmental Radiation Ambient Monitoring System (ERAMS) data. This site contains nationwide radiation monitoring data for air particulates, precipitation, drinking water, surface water and pasteurized milk. This site provides location-specific as well as national information on environmental radioactivity across several media. It provides high quality data for assessing public exposure and environmental impacts resulting from nuclear emergencies and provides baseline data during routine conditions. The database and website are accessible at www.epa.gov/enviro/. This site contains (1) a query for the general public which is easy to use--limits the amount of information provided, but includes the ability to graph the data with risk benchmarks and (2) a query for a more technical user which allows access to all of the data in the database, (3) background information on ER AMS.

Dziuban, J.; Sears, R.

2003-02-25T23:59:59.000Z

453