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Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMANEXPLOSIONS AND MEDICAL RADIATION . Jacob I. Fabrikant, MD,Low Levels of Ionizing Radiation, Yale University School of

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

2

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of Atomic Bomb Radiation Effects Life Span Study Report 8.reports derive mainly from the epidemiological studies of the Japanese atomic bomb

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

3

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

of the Current State of Radiation Protection Philosophy.Against Pergamon Ionizing Radiation from External Sources,for Protection Against Ionizing Radiation from Supplement to

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

4

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation Deok-Jin Jang 1 , Mingquan Guo 1 , Julia S.F.Chu 2 , Kyle T. Kurpinski 2 , Bjorn Rydberg 1 , Song Li 2 , and Daojing Wang 1 1. Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720 2. Department of Bioengineering, University of California, Berkeley, CA 94720 We will present data obtained during the first year of our DOE/NASA Low Dose Radiation Research program. We utilized a comprehensive approach including transcriptomics, proteomics, phosphoproteomics, and biochemistry to characterize human mesenchymal stem cells (MSCs) in response to low dose ionizing radiation. We first determined the cell survival, proliferation, and osteogenic differentiation of

5

Human Radiation Experiments: Multimedia  

NLE Websites -- All DOE Office Websites (Extended Search)

the oral histories of researchers and others possessing firsthand knowledge of human radiation experimentation during World War II and the Cold War. Film Clips: Document...

6

Disposition Schedule: Human Radiation Experiments | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Schedule: Human Radiation Experiments Disposition Schedule: Human Radiation Experiments This database contains information on records collections related to human radiation...

7

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

exposure to radioactive fallout in Radiation-Associated inIslanders, who were exposed to fallout H-bomb test explosion

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

8

Human Radiation Experiments: What's New  

NLE Websites -- All DOE Office Websites (Extended Search)

of Defense Report Finding Aids Department of Defense Report on Search for Human Radiation Experiments Records 1944-1994 Exit Human Radiation Experiments Site This...

9

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

Atomic Bomb by Radiation Dose, Years Research Research after Survivors, Hiroshima and Nagasaki, 1950-71 Exposure, Age,atomic bomb survivors in Hiroshima and Nagasaki (36), and the Japanese Here, 'here is an The latent age-

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

10

Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994  

SciTech Connect

Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

1995-05-01T23:59:59.000Z

11

Human radiation studies: Remembering the early years. Oral history of Merril Eisenbud, January 26, 1995  

SciTech Connect

Merril Eisenbud was interviewed on January 26, 1995 by representatives of the US DOE Office of Human Radiation Experiments. Following a brief biographical sketch, Mr. Eisenbud relates his remembrances as the AEC`s first industrial hygienist, the setting up of AEC`s Health and Safety Laboratory, monitoring radioactive fallout, and use or exposure of humans to radiation.

1995-05-01T23:59:59.000Z

12

Radiation effects on humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

13

Human radiation studies: Remembering the early years. Oral history of biophysicist Cornelius A. Tobias, Ph.D., January 16, 1995  

SciTech Connect

Dr. Cornelius A. Tobias was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). He was chosen for this interview because of his extensive biophysics and medical physics research activities while he was employed by the University of California, Berkeley and San Francisco and at the Donner Laboratory. He discusses his involvement in wartime studies of effects of high altitude on aviators, carbon monoxide with radioactive tracers, blood studies with radioactive iron, human use committees, heavy-ion research with the Bevatron, boron isotope research, classified research involving human subjects, heavy-particle radiography, heavy- particle beams and medical research, and pituitary irradiation studies,.

1995-07-01T23:59:59.000Z

14

Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995  

SciTech Connect

Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham`s involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others.

1995-09-01T23:59:59.000Z

15

Human radiation studies: Remembering the early years. Oral history of Oncologist Helen Vodopick, M.D., December 28, 1994  

SciTech Connect

This report is a transcript of an interview with Dr. Helen Vodopick by representatives of the US DOE Office of Human Radiation Experiments. Dr. Vodopick was chosen for this interview because of her involvement with the Oak Ridge Institute of Nuclear Studies (ORINS) and Oak Ridge Associated Universities (ORAU) experimental cancer-therapy program involving total-body irradiation. After a short biographical sketch Dr. Vodopick relates her remembrances of the Medium-Exposure-Rate Total Body Irradiator (METBI), ORINS radioisotope tracer studies, treatment of cancer patients with the METBI, radiation treatment for leukemia patients, bone marrow treatment of leukemia, the Low-Exposure-Rate Total Body Irradiation (LETBI), treatment of radiation accident victims at ORAU, research with radioactive phosphorus and sulfur, and public opinion issues.

1995-08-01T23:59:59.000Z

16

Human radiation studies: Remembering the early years: Oral history of radiation biologist Marvin Goldman, Ph.D., conducted December 22, 1994  

SciTech Connect

This report provides a transcript of an interview of Dr. Marvin Goldman by representatives of DOE`s Office of Human Radiation Experiments. Dr. Goldman was chosen for this interview because of his work on bone-seeking radionuclides. After a brief biographical sketch Dr. Goldman related his experiences concerning his training and work at Rochester University, his work at Brookhaven National Laboratory, his participation in the Beagle Studies at University of California at Davis, his work with the Chernobyl Nuclear Plant Accident, his consultation work with Russian authorities on the health and ecological effects in their history, and finally his opinions and recommendations on human radiation research and the environmental cleanup of DOE sites.

1995-09-01T23:59:59.000Z

17

Human radiation studies: Remembering the early years: Oral history of pathologist Clarence Lushbaugh, M.D., conducted October 5, 1994  

SciTech Connect

This report provides a transcript of an interview with Dr. Clarance Lushbaugh by representatives of the DOE Office of Human Radiation Experiments. Dr. Lushbaugh was chosen for this interview because of his research involving experimental use of irradiation with human beings at Los Alamos and at the Oak Ridge Institute of Nuclear Science (ORINS). After a brief biographical sketch Dr. Lushbaugh and his assistant Mrs. Ann Swipe defend their use of total body irradiation using the LETBI (Low Exposure Total Body Irradiation) and the LETBI (Medium Energy Total Body Irradiator). Dr. Lushbaugh also discusses his earlier experiments involving use of nitrogen mustards in chemotherapy application, his early interest in the LD50 for man, his early impressions of low-level spray radiation as introduced by Heubline, anedotal information for his duties a pathologist for Los Alamos, and his developing interest in establishing safer radiation limits for human exposure.

1995-04-01T23:59:59.000Z

18

Human radiation studies: Remembering the early years. Oral history of hematologist Karl F. Hubner, M.D., December 30, 1994  

SciTech Connect

This report is a transcript of an interview of Dr. Karl F. Hubner by representatives of the US DOE Human Radiation Experiments. Dr. Hubner was selected for this interview because of his participation in the Oak Ridge Institute of Nuclear Studies(ORINS)/Oak Ridge Associated Universities(ORAU) Medical Division cancer therapy research program involving total body irradiation. After a short biographical sketch Dr. Hubner discusses his research in Bone Marrow Transplants, his participation in the development of Nuclear Medicine in Oak Ridge, use of the total body irradiation machine at the University of Tennessee School of Agriculture Animal Research Laboratory (later the Comparative Animal Research Laboratory or CARL) to deliver a high enough dose rate to destroy a patients immune system, the operation of a sterile environment for recovery of patients following bone- marrow transplantation, and the closing of the ORAU Medical Division`s Clinical Program following a negative review. Finally, Dr. Hubner describes his later research using PET.

1995-09-01T23:59:59.000Z

19

Human radiation studies: Remembering the early years. Oral history of biochemist John Randolph Totter, Ph.D., January 23, 1995  

SciTech Connect

This document is a transcript of an interview of Dr. John Randolph Tottler by representatives of the US DOE Office of Human Radiation Experiments. Dr. Tottler was selected for this interview because of his career with the Atomic Energy Commission Division of Biology and Medicine (DBM), particularly as its director from 1967 to 1972. After a short biographical sketch Dr. Tottler discusses his remembrances on a wide range topics including nucleic acid and leukemia research at Oak Ridge, AEC biochemistry training in South America, DBM`s research focus on radiation effects, early leadership of DBM, relations with the US Public Health Service, controversies on low-level radiation, iodine from fallout, on John Gofman, and Project Plowshare, funding for AEC Research Programs and for international research, testicular irradiation of prisoners in Washington State and Oregon, Plutonium injections, ethics of government radiation research, and opinions of public misperceptions about radiation and cancer.

1995-09-01T23:59:59.000Z

20

Radiation-Induced Bystander Effects and Relevance to Human Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Bystander Effects and Relevance to Human Radiation Radiation-Induced Bystander Effects and Relevance to Human Radiation Exposures Review of phenomenon appears in Radiation Research Pamela Sykes and Benjamin Blyth One concern of radiobiologists is the effect radiation exposure might have on nearby unirradiated cells. For example, when only a small fraction of cells are directly hit by radiation energy, are the surrounding unirradiated cells also at an increased risk of cancer? The term "radiation-induced bystander effect" is used to describe radiation-induced biological changes that occur in unirradiated cells within an irradiated cell population. Radiation-induced bystander effects have become established in the vernacular and are considered as an authentic radiation response. However, there is still no consensus on a precise definition of the term, which

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Human radiation studies: Remembering the early years. Oral history of physiologist Nello Pace, Ph.D., August 16, 1994  

SciTech Connect

Dr. Nello Pace was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Pace was selected fro the interview because of the positions he held with the US Navy, at the University of California, Berkeley, and as Director of the White Mountain Research Station near Bishop, California. Following a brief biographical sketch, Dr. Pace related his remembrances concerning tritium injections experiments in animals and humans during World War II, the development of Medical Physics Degree Programs at UC Berkeley, conducting the first radiation survey at Nagasaki after the bomb, and the establishment of a research laboratory at White Mountain. He also offers reflections on Shields Warren and comments on the public`s attitudes towards radiation both then and now.

1995-06-01T23:59:59.000Z

22

Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994  

SciTech Connect

Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

1995-07-01T23:59:59.000Z

23

Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994  

SciTech Connect

Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and remembrances of John Lawrence, John Gofman, Cornelius Tobias, Jim Born, Alex Margolis, B.V.A. Low- Beer, and Ed Alpen. Further patient care procedures for Donner Clinic Research Programs were discussed.

1995-09-01T23:59:59.000Z

24

Human radiation studies: Remembering the early years. Oral history of Health physicist William J. Bair, Ph.D., October 14, 1994  

SciTech Connect

This report is a transcript of an interview of William J. Blair by representatives of the US DOE Office of Human Radiation Experiments. Dr. Blair was selected for this interview because of of his participation in the University of Rochester Atomic Energy Project and for his radiological inhalation research at Hanford Site. After a brief biographical sketch Dr. Blair discusses his remembrances on a wide rage of topics. Discussions include his graduate studies at Rochester University, use of human subjects at Rochester, his inhalation studies, his limited involvement with human studies, differing biological effects of plutonium 238 and 239, emissions from proposed nuclear-propelled aircraft, cancer research, cleanup at Nevada Test Site and Marshall Islands, impact of Langham studies to understand Plutonium exposure, and AEC controversies and colleagues.

Harrell, D.; Shindledecker, C.

1995-06-01T23:59:59.000Z

25

Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995  

SciTech Connect

NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee.

Fisher, D.; Melamed, E.

1995-07-01T23:59:59.000Z

26

Human radiation studies: Remembering the early years: Oral history of biochemist William D. Moss, conducted November 30, 1994  

SciTech Connect

This report is a transcript of an interview with William D. Moss by representatives of the US DOE Office of Human Radiation Experiments. Mr. Moss was selected for this interview because of his work at Los Alamos National Laboratory concerning analytical methods in the chemical determination of plutonium in biological materials. After a brief biographical sketch, Mr. Moss relates his understanding of how occupational exposure limits were determined for the Manhattan Project, how data from those workers who were exposed to plutonium was collected and analyzed, how the experiments were planned and data was gathered from plutonium or polonium injections in man, how problems with analytical procedures compounded health physics aspects of the project, and problems remaining in the interpretation of these data.

1995-09-01T23:59:59.000Z

27

Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995  

SciTech Connect

This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory.

1995-09-01T23:59:59.000Z

28

Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994  

SciTech Connect

This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission`s biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940`s and 1950`s including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities.

1995-08-01T23:59:59.000Z

29

Radiation Analysis for the Human Lunar Return Mission  

Science Conference Proceedings (OSTI)

An analysis of the radiation hazards that are anticipated on an early Human Lunar Return (HLR) mission in support of NASA deep space exploration activities is presented. The HLR mission study emphasized a low cost lunar return to expand human capabilities ...

Wilson J. W.; Simonsen L. C.; Shinn J. L.; Dubey R. R.; Jordan W.; Kim M.

1997-09-01T23:59:59.000Z

30

DOE Openess: Human Radiation Experiments - Roadmap to the Project  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Experiments: Roadmap to the Project DOE Shield DOE Openness: Human Radiation Experiment Roadmap to the Project Roadmap to the Project Home Roadmap What's New Search HREX...

31

Interim report of the Advisory Committee on human radiation experiments  

SciTech Connect

The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government`s role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future.

Not Available

1994-10-21T23:59:59.000Z

32

Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994  

SciTech Connect

This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists.

1995-06-01T23:59:59.000Z

33

Human radiation studies: Remembering the early years: Oral history of medical physicist Katherine L. Lathrop and physician Paul V. Harper, conducted January 26, 1995  

SciTech Connect

This report provides a transcript of an interview with Ms. Katherine L. Lathrop and Dr. Paul V. Hopper by representatives of the DOE Office of Human Radiation Research. Ms. Lathrop and Dr. Hopper were chosen for this interview because of their long-standing interest and research experience in the development of nuclear medicine. After brief biographical sketches the researchers provide a broad and interesting description of their roles in the initial uses of many radiopharmaceuticals, their experiences in human experimentation, and interactions with many other pioneers in nuclear medicine.

1995-09-01T23:59:59.000Z

34

Human radiation studies: Remembering the early years. Oral history of Dr. John W. Gofman, M.D., Ph.D., December 20, 1994  

SciTech Connect

Dr. John W. Gofman was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE) concerning his research at the University of California, Berkeley and his biomedical work at Lawrence Livermore Radiation Laboratory. Following a short biographical sketch, Dr. Gofman relates his remembrances with the discovery and chemistry of uranium-233, the Manhattan project, laboratory production of the first milligram of plutonium, pre-1945 medical use of high-dosage radiation, medical treatments with phosphorus 32, and fallout. Dr. Gofman also discusses his relationships with Professor Oppenheimer, Joe Hamilton, Ernest Lawrence, and other. Then Dr. Gofman describes his pioneering work on his true interests concerning heart disease, heparin, and lipoproteins. Finally intra-AEC political issues are discussed relating to testing of atomic weapons.

1995-06-01T23:59:59.000Z

35

Human radiation studies: Remembering the early years: Oral history of health physicist Karl Z. Morgan, Ph.D., conducted January 7, 1995  

SciTech Connect

This report provided a transcript of an interview of Dr. Karl. Z. Morgan by representatives of the DOE Office of Human Radiation Experiments. Dr. Morgan was selected for this interview because of his research for the Manhattan Project at the Metallurgical Laboratory in Chicago and his work at the Oak Ridge National Laboratory (ORNL). The oral history covers Dr. Morgan`s work as a pioneer in the field of Health Physics, his research at ORNL and his work since he retired from ORNL.

1995-06-01T23:59:59.000Z

36

Human radiation studies: Remembering the early years: Oral history of health physicist Constantine J. Maletskos, Ph.D., conducted January 20, 1995  

SciTech Connect

This report is a transcript of an interview with Dr. Constatine J. Maletskos by representatives of the DOE Office of Human Radiation Experiments. Dr. Maletskos was selected for this interview because of his research at the Radioactivity Center of the Massachusetts Institute of Technology (MIT), at the Harvard Medical School, and at the New England Deaconess Hospital. After a brief biographical sketches Dr. Maletskos discusses at length about his work at the Center on research that used subjects from the Walter E. Fernald State School in Waverly, Massachusetts and the New England Center for Aging, as well as blood volume work involving pregnant women. He further discusses his work with radium Dial Painters, his work with Dr. Robley Evans, and various other subjects concerning experiments with human subjects under the auspices of the AEC.

1995-09-01T23:59:59.000Z

37

EXPERIMENTAL STUDY OF THE THERMAL RADIATION ...  

Science Conference Proceedings (OSTI)

... developed for radiation ignition studies and was not adjusted from its normal settings which approximates to the radiation from a black body at 900 ...

2011-10-27T23:59:59.000Z

38

Quantitative Phosphoproteomics Identifies Filaggrin and other Targets of Ionizing Radiation in a Human Skin Model  

Science Conference Proceedings (OSTI)

Our objective here was to perform a quantitative phosphoproteomic study on a reconstituted human skin tissue to identify low and high dose ionizing radiation dependent signaling in a complex 3-dimensional setting. Application of an isobaric labeling strategy using sham and 3 radiation doses (3, 10, 200 cGy) resulted in the identification of 1113 unique phosphopeptides. Statistical analyses identified 151 phosphopeptides showing significant changes in response to radiation and radiation dose. Proteins responsible for maintaining skin structural integrity including keratins and desmosomal proteins (desmoglein, desmoplakin, plakophilin 1 and 2,) had altered phosphorylation levels following exposure to both low and high doses of radiation. A phosphorylation site present in multiple copies in the linker regions of human profilaggrin underwent the largest fold change. Increased phosphorylation of these sites coincided with altered profilaggrin processing suggesting a role for linker phosphorylation in human profilaggrin regulation. These studies demonstrate that the reconstituted human skin system undergoes a coordinated response to ionizing radiation involving multiple layers of the stratified epithelium that serve to maintain skin barrier functions and minimize the damaging consequences of radiation exposure.

Yang, Feng; Waters, Katrina M.; Webb-Robertson, Bobbie-Jo M.; Sowa, Marianne B.; Freiin von Neubeck, Claere H.; Aldrich, Joshua T.; Markillie, Lye Meng; Wirgau, Rachel M.; Gristenko, Marina A.; Zhao, Rui; Camp, David G.; Smith, Richard D.; Stenoien, David L.

2012-04-17T23:59:59.000Z

39

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

Advisory Committee on Human Radiation Experiments - Executive Summary Advisory Committee on Human Radiation Experiments - Executive Summary Publication Information The Creation of the Advisory Committee The President's Charge The Committee's Approach The Historical Context Key Findings Key Recommendations What's Next: The Advisory Committee's Legacy PUBLICATION INFORMATION The Final Report of the Advisory Committee on Human Radiation Experiments (stock number 061-000-00-848-9), the supplemental volumes to the Final Report (stock numbers 061-000-00850-1, 061-000-00851-9, and 061-000-00852-7), and additional copies of this Executive Summary (stock number 061-000-00849-7) may be purchased from the Superintendent of Documents, U.S. Government Printing Office. All telephone orders should be directed to: Superintendent of Documents

40

Human Radiation Experiments: Multimedia: Film Clips  

NLE Websites -- All DOE Office Websites (Extended Search)

Film Clips Multimedia Film Clips Multimedia Home Roadmap What's New Multimedia Related Sites Feedback Sound Bytes Film Clips Historical Photographs Films require: Get Real Player 5.0 to view the films on this page. The Atom and You Second in the series The Atom and You, Paramount News, March 25, 1953, shows tests conducted at Hanford, Washington, on effects of exposure of sheep and salmon to radiation; testing of radioactive dust at UCLA laboratory; the use of radioisotopes and tracer materials for detecting cancer in patients at Oak Ridge, Tennessee; the use of rays from the cobalt source at N.Y. city’s Moncure Hospital, to treat cancer of the brain. (Time: 5 min 9 secs) Real Media Download Versions 28.8 kbps version (782k) 56.0 kbps version (1.3mb) T1 version (7.5mb) Iodine 131

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Office of Human Radiation Experiments - Archived Website  

NLE Websites -- All DOE Office Websites (Extended Search)

documents cold war metabolism of lethal dose studies with rates dose experiments medical research program Iodine-131 Iron-59 For further information regarding information...

42

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

Part IV: Overview Part IV: Overview In part IV we present the overall findings of the Advisory Committee's inquiry and deliberations and the recommendations that follow from these findings. In chapter 17, findings are presented in two parts, first for the period 1944 through 1974 and then for the contemporary period. These parts, in turn, are divided into findings regarding biomedical experiments and those regarding population exposures. We begin our presentation of findings for the period 1944 through 1974 with a summation of what we have learned about human radiation experiments: their number and purpose, the likelihood that they produced harm, and how human radiation experimentation contributed to advances in medicine. We then summarize what we have found concerning the nature of federal rules and policies governing research involving human subjects during this period, and the implementation of these rules in the conduct of human radiation experiments. Findings about the nature and implementation of federal rules cover issues of consent, risk, the selection of subjects, and the role of national security considerations.

43

Advisory Committee on human radiation experiments final report  

SciTech Connect

When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

1995-10-01T23:59:59.000Z

44

Human radiation experiments associated with the US Department of Energy and its predecessors  

Science Conference Proceedings (OSTI)

This document contains a listing, description, and selected references for documented human radiation experiments sponsored, supported, or performed by the US Department of Energy (DOE) or its predecessors, including the US Energy Research and Development Administration (ERDA), the US Atomic Energy Commission (AEC), the Manhattan Engineer District (MED), and the Off ice of Scientific Research and Development (OSRD). The list represents work completed by DOE`s Off ice of Human Radiation Experiments (OHRE) through June 1995. The experiment list is available on the Internet via a Home Page on the World Wide Web (http://www.ohre.doe.gov). The Home Page also includes the full text of Human Radiation Experiments. The Department of Energy Roadmap to the Story and the Records (DOE/EH-0445), published in February 1995, to which this publication is a supplement. This list includes experiments released at Secretary O`Leary`s June 1994 press conference, as well as additional studies identified during the 12 months that followed. Cross-references are provided for experiments originally released at the press conference; for experiments released as part of The DOE Roadmap; and for experiments published in the 1986 congressional report entitled American Nuclear Guinea Pigs: Three Decades of Radiation Experiments on US Citizens. An appendix of radiation terms is also provided.

None

1995-07-01T23:59:59.000Z

45

Surface Solar Radiation Flux and Cloud Radiative Forcing for the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP): A Satellite, Surface Observations, and Radiative Transfer Model Study  

Science Conference Proceedings (OSTI)

This study presents surface solar radiation flux and cloud radiative forcing results obtained by using a combination of satellite and surface observations interpreted by means of a simple plane-parallel radiative transfer model called 2001. This ...

Catherine Gautier; Martin Landsfeld

1997-05-01T23:59:59.000Z

46

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

E-Print Network (OSTI)

R.B. Mikkelsen, Ionizing radiation-induced, mitochondria-W.K. Rorrer, P.B. Chen, Radiation-induced proliferation ofresponse genes to ionizing radiation in human lymphoblastoid

Wyrobek, A. J.

2011-01-01T23:59:59.000Z

47

Human Radiation Experiments: What's New: Press Briefing by Secretary of  

NLE Websites -- All DOE Office Websites (Extended Search)

THE WHITE HOUSE THE WHITE HOUSE Office of the Press Secretary For Immediate Release March 28, 1997 PRESS BRIEFING BY SECRETARY OF ENERGY FEDRICO PENA, ASSISTANT SECRETARY OF ENERGY TARA O'TOOLE, AND ACTING ASSOCIATE ATTORNEY GENERAL JOHN DWYER The Briefing Room 11:10 A.M. EST MS. GLYNN: Good morning, everybody. Today we have a human radiation report here. To brief is Secretary Federico Pena; Tara O'Toole, who is the Assistant Secretary of Energy for Environment, Safety and Health; and John Dwyer, the Acting Associate Attorney General. SECRETARY PENA: Thank you very much. Good morning, everybody. Dr. O'Toole, please come up, and John, join me here to my left and right. Let me begin by reading a statement from the President and then I have an opening comment. I'll introduce Dr. O'Toole and John to make some comments.

48

Human radiation experiments: The Department of Energy roadmap to the story and the records  

SciTech Connect

The role of the US Government in conducting or sponsoring human radiation experiments has become the subject of public debate. Questions have been raised about the purpose, extent, and health consequences of these studies, and about how subjects were selected. The extent to which subjects provided informed consent is also under scrutiny. To respond to these questions, the Clinton administration has directed the US Department of Energy (DOE), along with other Federal agencies, to retrieve and inventory all records that document human radiation experiments. Many such records are now publicly available and will permit an open accounting and understanding of what took place. This report summarizes the Department`s ongoing search for records about human radiation experiments. It is also a roadmap to the large universe of pertinent DOE information. DOE is working to instill greater openness--consistent with national security and other appropriate considerations--throughout its operations. A key aspect of this effort is opening DOE`s historical records to independent research and analysis.

1995-02-01T23:59:59.000Z

49

{sub p}53-Dependent Adaptive Responses in Human Cells Exposed to Space Radiations  

Science Conference Proceedings (OSTI)

Purpose: It has been reported that priming irradiation or conditioning irradiation with a low dose of X-rays in the range of 0.02-0.1 Gy induces a p53-dependent adaptive response in mammalian cells. The aim of the present study was to clarify the effect of space radiations on the adaptive response. Methods and Materials: Two human lymphoblastoid cell lines were used; one cell line bears a wild-type p53 (wtp53) gene, and another cell line bears a mutated p53 (mp53) gene. The cells were frozen during transportation on the space shuttle and while in orbit in the International Space Station freezer for 133 days between November 15, 2008 and March 29, 2009. After the frozen samples were returned to Earth, the cells were cultured for 6 h and then exposed to a challenging X-ray-irradiation (2 Gy). Cellular sensitivity, apoptosis, and chromosome aberrations were scored using dye-exclusion assays, Hoechst33342 staining assays, and chromosomal banding techniques, respectively. Results: In cells exposed to space radiations, adaptive responses such as the induction of radioresistance and the depression of radiation-induced apoptosis and chromosome aberrations were observed in wtp53 cells but not in mp53 cells. Conclusion: These results have confirmed the hypothesis that p53-dependent adaptive responses are apparently induced by space radiations within a specific range of low doses. The cells exhibited this effect owing to space radiations exposure, even though the doses in space were very low.

Takahashi, Akihisa [Department of Biology, School of Medicine, Nara Medical University, Nara (Japan); Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Su Xiaoming [Department of Biology, School of Medicine, Nara Medical University, Nara (Japan); Suzuki, Hiromi [Japan Space Forum, Tokyo (Japan); Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Omori, Katsunori [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Seki, Masaya; Hashizume, Toko [Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Advanced Engineering Services Company, Limited, Ibaraki (Japan); Shimazu, Toru [Japan Space Forum, Tokyo (Japan); Ishioka, Noriaki [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Iwasaki, Toshiyasu [Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of the Electric Power Industry of Japan, Tokyo (Japan); Ohnishi, Takeo, E-mail: tohnishi@naramed-u.ac.j [Department of Radiation Oncology, School of Medicine, Nara Medical University, Nara (Japan); Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan)

2010-11-15T23:59:59.000Z

50

ARM - Field Campaign - Carbonaceous Aerosol and Radiative Effects Study  

NLE Websites -- All DOE Office Websites (Extended Search)

govCampaignsCarbonaceous Aerosol and Radiative Effects Study (CARES) govCampaignsCarbonaceous Aerosol and Radiative Effects Study (CARES) Campaign Links CARES Website Related Campaigns Carbonaceous Aerosol and Radiation Effects Study (CARES) - Surface Meteorological Sounding 2010.05.26, Zaveri, OSC Carbonaceous Aerosol and Radiation Effects Study (CARES) Photo-Acoustic Aerosol Light Absorption and Scattering 2010.05.26, Arnott, OSC Carbonaceous Aerosol and Radiative Effects Study (CARES): SMPS & CCN counter deployment during CARES/Cal-NEx 2010.05.04, Wang, OSC Carbonaceous Aerosol and Radiative Effects Study (CARES) Ground Based Instruments 2010.04.01, Cziczo, OSC Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send Campaign : Carbonaceous Aerosol and Radiative Effects Study (CARES)

51

Regulation of Annexin A2 by Ionizing Radiation in Human Skin...  

NLE Websites -- All DOE Office Websites (Extended Search)

Annexin A2 by Ionizing Radiation in Human Skin Equivalent Culture: Does A Nuclear Annexin A2-Protein Kinase C Epsilon Complex Contribute To Reduced Cancer Risks At Low Dose...

52

Regulation of Annexin A2 by Ionizing Radiation in Human Skin...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Annexin A2 by Ionizing Radiation in Human Skin Equivalent Culture: Does A Nuclear Annexin A2-Protein Kinase C Epsilon Complex Contribute To Reduced Cancer Risks At Low...

53

Acceptability of risk from radiation: Application to human space flight  

SciTech Connect

This one of NASA`s sponsored activities of the NCRP. In 1983, NASA asked NCRP to examine radiation risks in space and to make recommendations about career radiation limits for astronauts (with cancer considered as the principal risk). In conjunction with that effort, NCRP was asked to convene this symposium; objective is to examine the technical, strategic, and philosophical issues pertaining to acceptable risk and radiation in space. Nine papers are included together with panel discussions and a summary. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

1997-04-30T23:59:59.000Z

54

Human Impact on Direct and Diffuse Solar Radiation during the Industrial Era  

Science Conference Proceedings (OSTI)

In this study the direct and diffuse solar radiation changes are estimated, and they contribute to the understanding of the observed global dimming and the more recent global brightening during the industrial era. Using a multistream radiative ...

Maria M. Kvalevg; Gunnar Myhre

2007-10-01T23:59:59.000Z

55

PLANNING STUDY FOR ADVANCED NATIONAL SYNCHROTRON-RADIATION FACILITIES  

NLE Websites -- All DOE Office Websites (Extended Search)

FOR ADVANCED NATIONAL SYNCHROTRON-RADIATION FACILITIES Printed March 14, 1984 The report of a study sponsored by the Department of Energy, Office of Basic Energy Sciences, and...

56

The One Million U.S. Radiation Worker Study  

NLE Websites -- All DOE Office Websites (Extended Search)

for chronic radiation exposure. Much knowledge has been gained from the study of atomic bomb survivors, but exposure was acute and 2 among a Japanese population living in...

57

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

Members and Staff Acknowledgments Documentary Note Preface Introduction - The Atomic Century Part I - Ethics of Human Subjects Research: A Historical Perspective Overview...

58

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

research involving healthy subjects: human experimentation conducted in conjunction with atomic bomb tests. More than 200,000 service personnel--now known as atomic...

59

A study of longwave radiation codes for climate studies: Validation with ARM observations and tests in general circulation models  

SciTech Connect

Research by the US Department of Energy (DOE) has shown that cloud radiative feedback is the single most important effect determining the magnitude of possible climatic responses to human activity. However, these effects are still not known at the levels needed for climate prediction. Consequently, DOE has launched a major initiative-- the Atmospheric Radiation Measurements (ARM) Program -- directed at improving the parameterization of the physics governing cloud and radiative processes in general circulation models (GCM's). One specific goal of ARM is to improve the treatment of radiative transfer in GCM's under clear-sky, general overcast and broken cloud conditions. Our approach to developing the radiation model will be to test existing models in an iterative, predictive fashion. We will supply the Clouds and Radiative Testbed (CART) with a set of models to be compared with operationally observed data. The differences we find will lead to the development of new models to be tested with new data. Similarly, our GCM studies will use existing GCM's to study the radiation sensitivity problem. We anticipate that the outcome of this approach will provide both a better longwave radiative forcing algorithm and a better understanding of how longwave radiative forcing influences the equilibrium climate of the atmosphere.

Ellingson, R.G.; Baer, F.

1992-01-01T23:59:59.000Z

60

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

Science Conference Proceedings (OSTI)

We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

2011-04-18T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Identification of novel ionizing radiation signaling targets in reconstituted human skin  

NLE Websites -- All DOE Office Websites (Extended Search)

of novel ionizing radiation signaling targets in reconstituted human skin of novel ionizing radiation signaling targets in reconstituted human skin Feng Yang, Katrina M. Waters, Bobbie-Jo Webb-Robertson, Lye-Meng Markillie, Rachel M. Wirgau, Shawna M. Hengel, Ljiljana Pasa-Tolic, and David L. Stenoien. Pacific Northwest National Laboratory Our focus has been on identifying the early events that occur after low dose ionizing radiation exposure that precede and often regulate downstream events such as altered transcription, protein secretion and epigenetic regulation. Phosphorylation is one of the earliest detectible events that occurs following radiation exposure and plays important roles in multiple biological pathways including DNA damage repair, transcription, apoptosis, and cell cycle progression. Very robust

62

Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report  

SciTech Connect

This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note.

1995-01-01T23:59:59.000Z

63

Studies of human mutation rates  

SciTech Connect

November 1989, marked the beginning of a new three-year cycle of DOE grant support, in connection with which the program underwent a major reorganization. This document presents the progress on the three objectives of the present program which are: to isolate by the technique of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), proteins of special interest because of the relative mutability of the corresponding gene, establish the identity of the protein, and, for selected proteins, move to a characterization of the corresponding gene; to develop a more efficient approach, based on 2-D PAGE, for the detection of variants in DNA, with special reference to the identification of mutations in the parents of the individual whose DNA is being examined; and, to continue an effective interface with the genetic studies on the children of atomic bomb survivors in Japan, with reference to both the planning and implementation of new studies at the molecular level.

Neel, J.V.

1990-01-01T23:59:59.000Z

64

Studies of human mutation rates  

SciTech Connect

The three objectives of the program are: To isolate by the technique of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), proteins of special interest because of the relative mutability of the corresponding gene, establish the identity of the protein, and, for selected proteins, move to a characterization of the corresponding gene; To develop a more efficient approach, based on 2-D PAGE, for the detection of variants in DNA, with special reference to the identification of a variant in a child not present in either parent of the child (i.e., a mutation); and, To continue an effective interface with the genetic studies on the children of atomic bomb survivors in Japan, with reference to both the planning and implementation of new studies at the molecular level. For administrative purposes, the program is subdivided into four sections, each under the direction of one of the four co-PIs; the progress during the past year will be summarized in accordance with this sectional structure. 1 tab.

Neel, J.V.

1991-07-15T23:59:59.000Z

65

Building Public Trust - Actions to Respond to the Report of the Advisory Committee on Human Radiation Experiments  

NLE Websites -- All DOE Office Websites (Extended Search)

Part 3: Righting Past Wrongs Part 3: Righting Past Wrongs Part 3: Righting Past Wrongs ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Overview The ACHRE report reviewed in detail several case studies of government-supported human radiation research including: the injections of plutonium into 18 hospital patients during and after World War II, research with prisoners, and research on patients who were exposed to total body irradiation in clinical settings. The Advisory Committee also considered issues related to certain radiation exposures associated with government activities that the Advisory Committee concluded should not be considered "human

66

Alterations in transcription factor binding in radioresistant human melanoma cells after ionizing radiation  

Science Conference Proceedings (OSTI)

We analyzed alterations in transcription factor binding to specific, known promoter DNA consensus sequences between irradiated and unirradiated radioresistant human melanoma (U1-Mel) cells. The goal of this study was to begin to investigate which transcription factors and DNA-binding sites are responsible for the induction of specific transcripts and proteins after ionizing radiation. Transcription factor binding was observed using DNA band-shift assays and oligonucleotide competition analyses. Confluence-arrested U1-Mel cells were irradiated (4.5 Gy) and harvested at 4 h. Double-stranded oligonucleotides containing known DNA-binding consensus sites for specific transcription factors were used. Increased DNA binding activity after ionizing radiation was noted with oligonucleotides containing the CREB, NF-kB and Sp1 consensus sites. No changes in protein binding to AP-1, AP-2, AP-3, or CTF/NF1, GRE or Oct-1 consensus sequences were noted. X-ray activation of select transcription factors, which bind certain consensus sites in promoters, may cause specific induction or repression of gene transcription. 22 refs., 2 figs.

Sahijdak, W.M.; Yang, Chin-Rang; Zuckerman, J.S.; Meyers, M.; Boothman, D.A. [Univ. of Wisconsin, Madison, WI (United States)

1994-04-01T23:59:59.000Z

67

Use of In Situ Observations to Characterize Cloud Microphysical and Radiative Properties: Application to Climate Studies  

NLE Websites -- All DOE Office Websites (Extended Search)

Use of In Situ Observations to Characterize Use of In Situ Observations to Characterize Cloud Microphysical and Radiative Properties: Application to Climate Studies G. M. McFarquhar and T. Nousiainen Department of Atmospheric Sciences University of Illinois Urbana, Illinois M. S. Timlin, S. F. Iacobellis, and R. C. J. Somerville Scripps Institution of Oceanography La Jolla, California Introduction Cloud radiative feedback is the most important effect determining climate response to human activity. Ice clouds reflect solar radiation and absorb thermal emission from the ground and the lower atmosphere and emit infrared radiation to space. The representation of these processes in models affects future climate predictions and there is much uncertainty in the representation of these processes. The size and

68

Radiation Damage Studies with Hadrons on Materials and Electronics  

E-Print Network (OSTI)

SLAC-PUB-10534 July 2004 Radiation Damage Studies withJ. Spencer. , Z. Wolf, SLAC, Menlo Park, CA 94025, USA M.J. Spencer ? Z. Wolf, SLAC, Menlo Park, CA 94025, USA M.

2004-01-01T23:59:59.000Z

69

A Solar Radiation Model for Use in Climate Studies  

Science Conference Proceedings (OSTI)

A solar radiation routine has been developed for use in climate studies. It includes the absorption and scattering due to ozone, water vapor, oxygen, carbon dioxide, clouds, and aerosols. Rayleigh scattering is also included. The UV and visible ...

Ming-Dah Chou

1992-05-01T23:59:59.000Z

70

Heat pipe radiation cooling evaluation: Task 2 concept studies report  

SciTech Connect

This report presents the result of Task 2, Concept Studies for Heat Pipe Radiation Cooling (HPRC), which was performed for Los Alamos National Laboratory under Contract 9-XT1-U9567. Studies under a prior contract defined a reference HPRC conceptual design for hypersonic aircraft engines operating at Mach 5 and an altitude of 80,000 ft. Task 2 involves the further investigation of heat pipe radiation cooling (HPRC) systems for additional design and operating conditions.

Silverstein, C.C.

1991-10-01T23:59:59.000Z

71

The influence of microwave radiation on the state of chromatin in human cells  

E-Print Network (OSTI)

Isolated human buccal epithelium cell were irradiated by microwaves at frequency f=35 GHz and surface power density E=30 mcW/cm2. The state of chromatin in human cells was determined by methodsof light and electron microscopy. The state of cell membranes was evaluated by the method of vital indigo carmine staining. The microwave-induced condensation of chromatin in human cells was revealed. Left side circulary polarized waves induced less effect than linearly polarized radiation. The linearly polarized electromagnetic waves induced cell membrane damage revealed by the increase of cell stainability. The data obtained are discussed in connection with the mechanisms of biologica effect of electromagnetic waves.

Shckorbatov, Y G; Grabina, V A; Kolchigin, N N; Batrakov, D O; Kalashnikov, V V; Ivanchenko, D D; Bykov, V N

2008-01-01T23:59:59.000Z

72

The influence of microwave radiation on the state of chromatin in human cells  

E-Print Network (OSTI)

Isolated human buccal epithelium cell were irradiated by microwaves at frequency f=35 GHz and surface power density E=30 mcW/cm2. The state of chromatin in human cells was determined by methodsof light and electron microscopy. The state of cell membranes was evaluated by the method of vital indigo carmine staining. The microwave-induced condensation of chromatin in human cells was revealed. Left side circulary polarized waves induced less effect than linearly polarized radiation. The linearly polarized electromagnetic waves induced cell membrane damage revealed by the increase of cell stainability. The data obtained are discussed in connection with the mechanisms of biologica effect of electromagnetic waves.

Y. G. Shckorbatov; V. N. Pasiuga; V. A. Grabina; N. N. Kolchigin; D. O. Batrakov; V. V. Kalashnikov; D. D. Ivanchenko; V. N. Bykov

2008-09-03T23:59:59.000Z

73

MECHANISTIC STUDY OF LOW DOSE RADIATION INDUCED PROTEOLYTIC CASCADES  

NLE Websites -- All DOE Office Websites (Extended Search)

Cells organize into tissue-like structures which recapitulate the intact human mammary gland morphology (Figure 1) enabling molecular level study of how normal tissues respond...

74

Clear Skies A Study of Longwave Radiation Codes for Climate Studies...  

NLE Websites -- All DOE Office Websites (Extended Search)

Study of Longwave Radiation Codes for Climate Studies: Validation with Observations and Tests in General Circulation Models-an Update R. G. Ellingson and F. Baer Department of...

75

Executive summary and guide to final report: Advisory committee on human radiation experiments  

SciTech Connect

On January 15, 1994, President Clinton appointed the Advisory Committee on Human Radiation Experiments to investigate reports of possibly unethical experiments funded by the government decades ago. The Committee was directed to uncover the history of human radiation experiments during the period 1944 through 1974 and to examine cases in which the government had intentionally released radiation into the environment for research purposes. The Committee was further charged with identifying the ethical and scientific standards for evaluating these events, and with making recommendations to ensure that whatever wrongdoing may have ocurred in the past cannot be repeated. The Committee undertook three projects: A review of how each agency of the federal government that currently conducts or funds research involving human subjects regulates this activity or oversees it; An examination of the documents and consent forms of research projects that are today sponsored by the federal government in order to develop insight into the current status of protections for the rights and interests of human subjects; and, Interviews of nearly 1,900 patients receiving out-patient medical care in private hospitals and federal facilities throughout the country. This booklet provides an overview of the Final Report, summarizing each chapter.

1995-01-01T23:59:59.000Z

76

Genome Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013  

SciTech Connect

During course of this project, we have worked in several areas relevant to low-dose ionizing radiation. Using gene expression to measure biological response, we have examined the response of human skin exposed in-vivo to radation, human skin exposed ex-vivo to radiation, and a human-skin model exposed to radiation. We have learned a great deal about the biological response of human skin to low-dose ionizing radiation.

Rocke, David M. [University of California Davis

2013-09-09T23:59:59.000Z

77

Advisory Committee on human radiation experiments. Supplemental, Volume 1, Ancillary materials. Final report  

SciTech Connect

This report is a large collection of contemporary documents pertaining to the consideration of ethical and legal aspects of use of human beings in medical and experimental studies.

1995-01-01T23:59:59.000Z

78

Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation  

SciTech Connect

Nuclear factor kB (NF-kB) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kB in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kB in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to {sup 137}Cs {gamma} rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kB was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kB was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kB subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy. 32 refs., 3 figs.

Prasad, A.V.; Mohan, N.; Meltz, M.L.; Chandrasekar, B. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-06-01T23:59:59.000Z

79

Technical Sessions A Study of Longwave Radiation Codes for Climate Studies:  

NLE Websites -- All DOE Office Websites (Extended Search)

A Study of Longwave Radiation A Study of Longwave Radiation Codes for Climate Studies: Validation with ARM Observations and Tests in General Circulation Models R. G. Ellingson F. Baer Department of Meteorology University of Maryland College Park, MD 20742 Introduction the radiation sensitivity problem. We anticipate that the outcome of this approach will provide both a better longwave radiative forcing algorithm and a better understanding of how longwave radiative forcing influences the equilibrium climate of the atmosphere. Nature of Longwave Problems Longwave radiation quantities-radiances, fluxes and heating rates-are usually calculated in GCM models as the cloud amount weighted average of the values for clear and homogeneous cloud conditions. For example, the downward flux at the surface, F, may be written as

80

Fog-82: A Cooperative Field Study of Radiation Fog  

Science Conference Proceedings (OSTI)

The Cloud Physics Section of the Atmospheric Sciences Research Center-State University of New York at Albany conducted a cooperative field study (FOG-82) during the autumn of 1982 as part of an ongoing radiation-fog research program. A computer-...

Michael B. Meyer; G. Garland Lala; James E. Jiusto

1986-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates  

Science Conference Proceedings (OSTI)

Purpose: To test whether pharmacologic inhibition of ribonucleotide reductase (RNR) by 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC no. 663249) enhances radiation sensitivity during low-dose-rate ionizing radiation provided by a novel purpose-built iridium-192 cell irradiator. Methods and Materials: The cells were exposed to low-dose-rate radiation (11, 23, 37, 67 cGy/h) using a custom-fabricated cell irradiator or to high-dose-rate radiation (330 cGy/min) using a conventional cell irradiator. The radiation sensitivity of human cervical (CaSki, C33-a) cancer cells with or without RNR inhibition by 3-AP was evaluated using a clonogenic survival and an RNR activity assay. Alteration in the cell cycle distribution was monitored using flow cytometry. Results: Increasing radiation sensitivity of both CaSki and C33-a cells was observed with the incremental increase in radiation dose rates. 3-AP treatment led to enhanced radiation sensitivity in both cell lines, eliminating differences in cell cytotoxicity from the radiation dose rate. RNR blockade by 3-AP during low-dose-rate irradiation was associated with low RNR activity and extended G{sub 1}-phase cell cycle arrest. Conclusions: We conclude that RNR inhibition by 3-AP impedes DNA damage repair mechanisms that rely on deoxyribonucleotide production and thereby increases radiation sensitivity of human cervical cancers to low-dose-rate radiation.

Kunos, Charles A., E-mail: charles.kunos@UHhospitals.org [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Colussi, Valdir C. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Pink, John [Department of General Medical Sciences, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Radivoyevitch, Tomas [Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Oleinick, Nancy L. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States)

2011-07-15T23:59:59.000Z

82

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans  

SciTech Connect

Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated in irradiated human diploid fibroblasts. ASPM was recently reported as the causative gene for MCPH-5, the most common type of congenital microcephaly in humans. Here, we show that the expression of the Aspm gene was significantly reduced by IR in various human and murine cells. Additionally, Aspm was found downregulated in the irradiated fetal mouse brain, particularly in the ventricular zones. A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation.

Fujimori, Akira [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)], E-mail: fujimora@nirs.go.jp; Yaoi, Takeshi; Ogi, Hiroshi [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan); Wang Bing [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Suetomi, Katsutoshi; Sekine, Emiko; Yu Dong; Kato, Takamitsu [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Takahashi, Sentaro [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Okayasu, Ryuichi [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Itoh, Kyoko; Fushiki, Shinji [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan)

2008-05-09T23:59:59.000Z

83

A study of longwave radiation codes for climate studies: Validation with ARM observations and tests in general circulation models. Technical report, 16 March 1991--15 March 1992  

SciTech Connect

Research by the US Department of Energy (DOE) has shown that cloud radiative feedback is the single most important effect determining the magnitude of possible climatic responses to human activity. However, these effects are still not known at the levels needed for climate prediction. Consequently, DOE has launched a major initiative-- the Atmospheric Radiation Measurements (ARM) Program -- directed at improving the parameterization of the physics governing cloud and radiative processes in general circulation models (GCM`s). One specific goal of ARM is to improve the treatment of radiative transfer in GCM`s under clear-sky, general overcast and broken cloud conditions. Our approach to developing the radiation model will be to test existing models in an iterative, predictive fashion. We will supply the Clouds and Radiative Testbed (CART) with a set of models to be compared with operationally observed data. The differences we find will lead to the development of new models to be tested with new data. Similarly, our GCM studies will use existing GCM`s to study the radiation sensitivity problem. We anticipate that the outcome of this approach will provide both a better longwave radiative forcing algorithm and a better understanding of how longwave radiative forcing influences the equilibrium climate of the atmosphere.

Ellingson, R.G.; Baer, F.

1992-06-01T23:59:59.000Z

84

Studies of human mutation. Final report, [November 1, 1987--May 31, 1996  

Science Conference Proceedings (OSTI)

This is the final report on this grant, covering the period November 1, 1987 through May 31, 1996. This program was devoted to developing better technologies for the study of mutations in human populations. Work included studies on the radiation effects on genetic mutations in Hiroshima atomic bomb survivors, development of new methods for detecting mutations, collection of data on the genetic population structure of native Central Americans, and other miscellaneous related activities.

Neel, J.V.; Hanash, S.M.

1996-09-01T23:59:59.000Z

85

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Understanding how human organs respond to ionizing radiation (IR) at a systems biology level and identifying biomarkers for IR exposure at low doses can help provide a scientific basis for establishing radiation protection standards. Little is known regarding the physiological responses to low dose IR at the metabolite level, which represents the end-point of biochemical processes inside cells. Using a full thickness human skin tissue model and GC-MS-based metabolomics analysis, we examined the metabolic perturbations at three time points (3, 24 and 48 hr) after exposure to 3, 10 and 200 cGy of X-rays. PLS-DA score plots revealed dose- and time-dependent clustering between sham and irradiated groups. Importantly, a comparable number of metabolites were detected to have significant change 48 hr after exposure to 3 and 10 cGy of irradiation, when compared with the high dose of 200 cGy. Biochemical pathway analysis showed perturbations to DNA/RNA damage and repair, lipid and energy metabolisms, even at low doses of IR.

Hu, Zeping; Kim, Young-Mo; Sowa, Marianne B.; Robinson, Robert J.; Gao, Xiaoli; Metz, Thomas O.; Morgan, William F.; Zhang, Qibin

2012-05-18T23:59:59.000Z

86

A Study of Radiative Bottomonium Transitions using Converted Photons  

SciTech Connect

The authors use (111 {+-} 1) million {Upsilon}(3S) and (89 {+-} 1) million {Upsilon}(2S) events recorded by the BABAR detector at the PEP-II B-factory at SLAC to perform a study of radiative transitions betwen bottomonium states using photons that have been converted to e{sup +}e{sup -} pairs by the detector material. They observe {Upsilon}(3S) {yields} {gamma}{chi}{sub b0,2}(1P) decay, make precise measurements of the branching fractions for {chi}{sub b1,2}(1P, 2P) {yields} {gamma}{Upsilon}(1S) and {chi}{sub b1,2}(2P) {yields} {gamma}{Upsilon}(2S) decays, and search for radiative decay to the {eta}{sub b}(1S) and {eta}{sub b}(2S) states.

Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; /INFN, Bari /Bari U.; Milanes, D.A.; /INFN, Bari; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

2011-08-15T23:59:59.000Z

87

A revised model for radiation dosimetry in the human gastrointestinal tract  

E-Print Network (OSTI)

A new model for an adult human gastrointestinal tract (GIT) has been developed for use in internal dose estimations to the wall of the GIT and to the other organs and tissues of the body from radionuclides deposited in the lumenal contents of the five sections of the GIT. These sections were the esophagus, stomach, small intestine, upper large intestine, and the lower large intestine. The wall of each section was separated from its lumenal contents. Each wall was divided into many small regions so that the histologic and radiosensitive variations of the tissues across the wall could be distinguished. The characteristic parameters were determined based on the newest information available in the literature. Each of these sections except the stomach was subdivided into multiple subsections to include the spatiotemporal variations in the shape and characteristic parameters. This new GIT was integrated into an anthropomorphic phantom representing both an adult male and a larger-than-average adult female. The current phantom contains 14 different types of tissue. This phantom was coupled with the MCNP 4C Monte Carlo simulation package. The initial design and coding of the phantom and the Monte Carlo treatment employed in this study were validated using the results obtained by Cristy and Eckerman (1987). The code was used for calculating specific absorbed fractions (SAFs) in various organs and radiosensitive tissues from uniformly distributed sources of fifteen monoenergetic photons and electrons, 10 keV - 4 MeV, in the lumenal contents of the five sections of the GIT. The present studies showed that the average photon SAFs to the walls were significantly different from that to the radiosensitive cells (stem cells) for the energies below 50 keV. Above 50 keV, the photon SAFs were found to be almost constant across the walls. The electron SAF at the depth of the stem cells was a small fraction of the SAF routinely estimated at the contents-mucus interface. Electron studies showed that the self-dose for the energies below 300 keV and the cross-dose below 2 MeV were only from bremsstrahlung and fluorescent radiations at the depth of the stem cells and were not important.

Bhuiyan, Md. Nasir Uddin

2003-08-01T23:59:59.000Z

88

Beta Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Beta Radiation 1. Beta radiation may travel meters in air and is moderately penetrating. 2. Beta radiation can penetrate human skin to the "germinal layer," where new skin cells...

89

Radiation Damage Study for PHENIX Silicon Stripixel Sensors  

E-Print Network (OSTI)

Silicon stripixel sensors which were developed at BNL will be installed as part of the RHIC-PHENIX silicon vertex tracker (VTX). RHIC II operations provide luminosity up to 2x10^32 /cm2/s so the silicon stripixel sensors will be exposed to a significant amount of radiation. The most problematic radiation effect for VTX is the increase of leakage current, which degrades the signal to noise ratio and may saturate the readout electronics. We studied the radiation damage using the same diodes as CERN-RD48. First, the proportionality between the irradiation fluence and the increase of leakage current of CERN-RD48 was reproduced. Then beam experiments with stripixel sensor were done in which leakage current was found to increase in the same way as that of thereference diode. A stripixel sensor was also irradiated at the PHENIX interaction region (IR) during the 2006 run. We found the same relation between the integrated luminosity and determined fluence from increase of leakage current. The expected fluence is 3-6x10^12 Neq/cm2 (1 MeV neutron equivalent) in RHIC II operations for 10 years. Due to this expected exposure, setting the operating temperature in PHENIX to T< 0 deg. C to suppress leakage current is needed to avoid saturation of preamplifiers.

J. Asai; S. Batsouli; K. Boyle; V. Castillo; V. Cianciolo; D. Fields; C. Haegeman; M. Hoeferkamp; Y. Hosoi; R. Ichimiya; Y. Inoue; M. Kawashima; T. Komatsubara; K. Kurita; Z. Li; D. Lynch; M. Nguyen; T. Murakami; R. Nouicer; H. Ohnishi; R. Pak; K. Sakashita; T. -A. Shibata; K. Suga; A. Taketani; J. Tojo

2007-10-14T23:59:59.000Z

90

Building Public Trust - Actions to Respond to the Report of the Advisory Committee on Human Radiation Experiments  

NLE Websites -- All DOE Office Websites (Extended Search)

B-1 B-1 Appendix B APPENDIX B ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ACCESS TO RECORDS AND INFORMATION RELATING TO HUMAN RADIATION EXPERIMENTS Advisory Committee on Human Radiation Experiments (ACHRE) Collection at the National Archives, College Park Overview: 665 cubic feet of records from the Advisory Committee on Human Radiation Experiments have been deposited at the National Archives and made part of Record Group 220, Presidential Commit- tees, Commissions, and Boards. The collection can be accessed through the Archive's Textual Reference Branch located at Archives II, 8601 Adelphi Road, College Park, Maryland. The phone number

91

Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments  

Science Conference Proceedings (OSTI)

Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

NONE

1997-03-01T23:59:59.000Z

92

Radiation-induced leukemia: Comparative studies in mouse and man  

SciTech Connect

We now have a clear understanding of the mechanism by which radiation-induced (T-cell) leukemia occurs. In irradiated mice (radiation-induced thymic leukemia) and in man (acute lymphoblastic T-cell leukemia, T-ALL) the mechanism of leukemogenesis is surprisingly similar. Expressed in the most elementary terms, T-cell leukemia occurs when T-cell differentiation is inhibited by a mutation, and pre-T cells attempt but fail to differentiate in the thymus. Instead of leaving the thymus for the periphery as functional T-cells they continue to proliferate in the thymus. The proliferating pre- (pro-) T-cells constitute the (early) acute T-cell leukemia (A-TCL). This model for the mechanism of T-cell leukemogenesis accounts for all the properties of both murine and human A-TCL. Important support for the model has recently come from work by Ilan Kirsch and others, who have shown that mutations/deletions in the genes SCL (TAL), SIL, and LCK constitute primary events in the development of T-ALL, by inhibiting differentiation of thymic pre- (pro-) T-cells. This mechanism of T-cell leukemogenesis brings several specific questions into focus: How do early A-TCL cells progress to become potently tumorigenic and poorly treatable Is it feasible to genetically suppress early and/or progressed A-TCL cells What is the mechanism by which the differentiation-inhibited (leukemic) pre-T cells proliferate During the first grant year we have worked on aspects of all three questions.

Haas, M.

1991-01-01T23:59:59.000Z

93

Building Public Trust - Actions to Respond to the Report of the Advisory Committee on Human Radiation Experiments  

NLE Websites -- All DOE Office Websites (Extended Search)

Part 2: Protecting Future Human Subjects Part 2: Protecting Future Human Subjects Part 2: Protecting Future Human Subjects ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Overview The success of the effort to open the historical record will be measured, in part, by whether we avoid repeating the mistakes of the past. ACHRE's review of human radiation experiments raised questions of whether the current system of protection is adequate for all types of human subjects research. The measures described below will strengthen the protection of human subjects and address ACHRE's findings. Federal responsibilities for maintaining ethics in human subjects research are dispersed in several agencies and committees in the

94

New study sees greater low-level radiation threat  

SciTech Connect

A new analysis of Energy Department medical records has found higher than expected cancer rates among workers at DOE's Hanford nuclear weapons plant, suggesting occupational exposure to low-level radiation may be more dangerous than previously thought. The study, released Tuesday by the Philadelphia-based Three Mile Island Public Health Fund, is important not only because of its controversial conclusions, but also because it represents the first independent review of DOE's long-secret worker medical records. The new study done by Stewart and Kneale looked at Hanford worker health records dating up to 1986 - part of a huge trove of data withheld by DOE from independent researchers until two years ago. In their re-analysis of the Hanford worker records, Stewart and Kneale found increased cancer rates among older workers who were over 40 years of age when exposed. And they said that increased susceptibility of older people to radiation-induced cancer was not reflected in the highly influential Japanese atomic bomb studies because people over 50 years of age were [open quotes]grossly under-represented[close quotes] in the A-bomb analyses, possibly because many bomb victims suffered early deaths from high doses.

Lobsenz, G.

1992-12-09T23:59:59.000Z

95

Radiators  

SciTech Connect

A heat-exchange radiator is connected to a fluid flow circuit by a connector which provides one member of an interengageable spigot and socket pair for push-fit, fluid-tight, engagement between the connector and the radiator, with latching formations at least one of which is resilient. Preferably the connector carries the spigot which tapers and engages with a socket of corresponding shape, the spigot carrying an O-ring seal and either latching fingers or a resilient latching circlip.

Webster, D. M.

1985-07-30T23:59:59.000Z

96

The NOAA Integrated Surface Irradiance Study (ISIS)A New Surface Radiation Monitoring Program  

Science Conference Proceedings (OSTI)

This paper describes a new radiation monitoring program, the Integrated Surface Irradiance Study (ISIS), that builds upon and takes over from earlier NOAA networks monitoring components of solar radiation [both the visible component (SOLRAD) and ...

B. B. Hicks; J. J. DeLuisi; D. R. Matt

1996-12-01T23:59:59.000Z

97

Building Public Trust - Actions to Respond to the Report of the Advisory Committee on Human Radiation Experiments  

NLE Websites -- All DOE Office Websites (Extended Search)

Executive Summary Executive Summary Executive Summary ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ "Our greatness is measured not only in how we . . . do right but also [in] how we act when we know we've done the wrong thing; how we confront our mistakes, make our apologies, and take action." -President Clinton October 3, 1995 In January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE) to examine reports that the government had funded and conducted unethical human radiation experiments and releases of radiation during the

98

Radiation evaluation study of LSI RAM technologies. Final report  

SciTech Connect

Five commercial LSI static RAM technologies having a 1 kilobit capacity were radiation characterized. Arrays from the TTL, Schottky TTL, NMOS, CMOS, and CMOS/SOS families were evaluated. Radiation failure thresholds for gamma dose-rate logic upset, total gamma dose survivability, and neutron fluence survivability were determined. Included is a brief analysis of the radiation failure mechanism for each of the logic families tested.

Dinger, G.L.; Knoll, M.G.

1980-01-01T23:59:59.000Z

99

ORISE: Worker Health Studies - Radiation Exposure Data Collection  

NLE Websites -- All DOE Office Websites (Extended Search)

Overview Argonne Electronic Medical Records System Beryllium Testing and Surveillance Radiation Exposure Information and Reporting System (REIRS) U.S. Department of Energy...

100

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  

SciTech Connect

Purpose: Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damage sensor ataxia-telangiectasia mutated (ATM). We explored the regulation of AMPK by ionizing radiation (IR) and its role as a target for radiosensitization of human cancer cells. Methods and Materials: Lung, prostate, and breast cancer cells were treated with IR (2-8 Gy) after incubation with either ATM or AMPK inhibitors or the AMPK activator metformin. Then, cells were subjected to either lysis and immunoblotting, immunofluorescence microscopy, clonogenic survival assays, or cell cycle analysis. Results: IR induced a robust phosphorylation and activation of AMPK in all tumor cells, independent of LKB1. IR activated AMPK first in the nucleus, and this extended later into cytoplasm. The ATM inhibitor KU-55933 blocked IR activation of AMPK. AMPK inhibition with Compound C or anti-AMPK {alpha} subunit small interfering RNA (siRNA) blocked IR induction of the cell cycle regulators p53 and p21{sup waf/cip} as well as the IR-induced G2/M arrest. Compound C caused resistance to IR, increasing the surviving fraction after 2 Gy, but the anti-diabetic drug metformin enhanced IR activation of AMPK and lowered the surviving fraction after 2 Gy further. Conclusions: We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21{sup waf/cip} and regulation of the cell cycle and survival. AMPK appears to (1) participate in an ATM-AMPK-p21{sup waf/cip} pathway, (2) be involved in regulation of the IR-induced G2/M checkpoint, and (3) may be targeted by metformin to enhance IR responses.

Sanli, Toran; Rashid, Ayesha; Liu Caiqiong [Department of Oncology, Juravinski Cancer Center and McMaster University, Hamilton, Ontario (Canada)

2010-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Alpha Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Basics of Radiation Basics of Radiation Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Basics of Radiation Characteristics of Alpha Radiation 1. Alpha radiation is not able to penetrate skin. 2. Alpha-emitting materials can be harmful to humans if the materials are inhaled, swallowed, or absorbed through open wounds. 3. A variety of instruments have been designed to measure alpha radiation. Special training in use of these instruments is essential for making accurate measurements. 4. A civil defense instrument (CD V-700) cannot detect the presence of radioactive materials that produce alpha radiation unless the radioactive materials also produce beta and/or gamma radiation.

102

Comparison of Unmonochromatized Synchrotron Radiation and Conventional X-rays in the Imaging of Mammographic Phantom and Human Breast Specimens: A Preliminary Result  

E-Print Network (OSTI)

A simple imaging setup based on the principle of coherence-based contrast X-ray imaging with unmonochromatized synchrotron radiation was used for studying mammographic phantom and human breast specimens. The use of unmonochromatized synchrotron radiation simplifies the instrumentation, decreases the cost and makes the procedure simpler and potentially more suitable for clinical applications. The imaging systems consisted of changeable silicon wafer attenuators, a tungsten slit system, a CdWO4 scintillator screen, a CCD (Charge Coupled Device) camera coupled to optical magnification lenses, and a personal computer. In preliminary studies, a spatial resolution test pattern and glass capillary filled with air bubbles were imaged to evaluate the resOolution characteristics and coherence-based contrast enhancement. Both the spatial resolution and image quality of the proposed system

Haijo Jung; Hee-joung Kim; Eun-kyung Kim; Jin-o Hong; Jung Ho Je; Yeukuang Hwu; Wen-li Tsai; Giorgio Magaritondo; Hyung-sik Yoo

2004-01-01T23:59:59.000Z

103

Coastal-inland solar radiation difference study. Final report  

DOE Green Energy (OSTI)

The purpose of this study was to quantify the characteristics of solar insolation in the coastal zone and to determine the effect of the sea breeze circulation on the global insolation. In order to satisfy these objectives, a six station sampling network was established in the coastal plain of southeastern North Carolina, where previous evidence has indicated that the sea breeze circulation is almost a daily occurrence from late May through October. Three sites (Sloop Point, Onslow Beach, and Cape Fear Technical Institute (CFTI)) were located near the coast (coastal sites) to assess the insolation at the coast. A site (Clinton) was located in an area seldom affected by the sea breeze (about 100 km from the coast). Two additional sites, Wallace and Ellis Airport, located between the coastal sites and the control site, were to be used to assess the transient impact of the sea breeze upon the insolation. Pyranometers were located at each site to measure the global insolation. Direct normal insolation measured by a pyrheliometer and ultraviolet radiation measured by uv radiometers were observed at the Sloop Point and Clinton sites only. Data were collected during the calendar year 1978. The results of the study indicated that the global insolation had greater variability over the network during the summer season (June, July, and August). During the summer, there was a systematicdiurnal variation of the difference in global insolation between the inland and the coastal sites.

Bach, W.D. Jr.; Vukovich, F.M.

1980-04-01T23:59:59.000Z

104

Ionizing radiation induces IL-6-production by human fibroblasts involving activation of nuclear factor-. kappa. B  

Science Conference Proceedings (OSTI)

The authors report that human lung fibroblasts respond to X-ray treatment with release of interleukin (IL) -6. Synthesis of IL-6 upon ionizing radiation is preceded by an increase of IL-6 transcript levels resulting from transcriptional activation of the IL-6 gene. Analysis of deleted fragments of the IL-6 promoter revealed that transcriptional induction of the IL-6 promoter is due to enhanced binding activity of the transcription factor NF-kB. Although AP-1 does not participate in the rapid induction of the IL-6 promoter its binding activity is also enhanced upon XRT. In contrast to binding kinetics observed with NF-kB, AP-1 binding upon XRT. In contrast to binding kinetics observed with NF-kB- and the AP-1 recognition sequence, conferred inducibility by XRT to a heterologous promoter, with reporter gene activity being maximal 24 hours or 48 hours upon XRT, respectively. Sequential activation of two distinct transcription factors might thus contribute to synchronize transcriptional activation of different genes participating in the X-ray response.

Brach, M.A.; Gruss, H.J.; Kaisho, Tsuneyasu; Asano, Yoshinobu; Vos, Sven de; Mertelsmann, R.; Hirano, Toshio; Herrmann, F. (Univ. of Freiburg (Germany) Osaka Univ. (Japan))

1992-02-26T23:59:59.000Z

105

A Systematic Study of Longwave Radiative Heating and Cooling within Valleys and Basins Using a Three-Dimensional Radiative Transfer Model  

Science Conference Proceedings (OSTI)

The Monte Carlo code for the physically correct tracing of photons in cloudy atmospheres (MYSTIC) three-dimensional radiative transfer model was used in a parametric study to determine the strength of longwave radiative heating and cooling in ...

Sebastian W. Hoch; C. David Whiteman; Bernhard Mayer

2011-12-01T23:59:59.000Z

106

Radiation Energy Budget Studies Using Collocated AVHRR and ERBE Observations  

Science Conference Proceedings (OSTI)

Changes in the energy balance at the top of the atmosphere are specified as a function of atmospheric and surface properties using observations from the Advanced Very High Resolution Radiometer (AVURR) and the Earth Radiation budget Experiment (...

Steven A. Ackerman; Toshiro Inoue

1994-03-01T23:59:59.000Z

107

Study of a nonhomogeneous aerogel radiator in a proximity focusing  

E-Print Network (OSTI)

The use of a nonhomogeneous aerogel radiator, i.e. one consisting of layers with different refractive indices, has been shown to improve the resolution of the Cherenkov angle measured with a proximity focusing RICH detector. In order to obtain further information on the performance of such a detector, a simple model has been used to calculate the resolution and search for optimal radiator parameters. 1.

Rich Detector; Peter Kri?zan Ab; Samo Korpar Cb; Toru Iijima D

2006-01-01T23:59:59.000Z

108

Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage  

Science Conference Proceedings (OSTI)

Purpose: Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable FGF1 mutants were created increasing stability in the order, wild-type FGF1, single mutants (Q40P, S47I, and H93G), Q40P/S47I, and Q40P/S47I/H93G. This study evaluated the contribution of the structural stability of FGF1 to its radioprotective effect. Methods and Materials: Each FGF1 mutant was administered intraperitoneally to BALB/c mice in the absence of heparin 24 h before or after total body irradiation (TBI) with {gamma}-rays at 8-12 Gy. Several radioprotective effects were examined in the jejunum. Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. Preirradiation treatment with Q40P/S47I/H93G significantly increased crypt survival more than wild-type FGF1 after TBI at 10 or 12 Gy, and postirradiation treatment with Q40P/S47I/H93G was effective in promoting crypt survival after TBI at 10, 11, or 12 Gy. In addition, crypt cell proliferation, crypt depth, and epithelial differentiation were significantly promoted by postirradiation treatment with Q40P/S47I/H93G. The level of stability of FGF1 mutants correlated with their mitogenic activities in vitro in the absence of heparin; however, preirradiation treatment with the mutants increased the crypt number to almost the same level as Q40P/S47I/H93G. When given 24 h after TBI at 10 Gy, all FGF1 mutants increased crypt survival more than wild-type FGF1, and Q40P/S47I/H93G had the strongest mitogenic effects in intestinal epithelial cells after radiation damage. Moreover, Q40P/S47I/H93G prolonged mouse survival after TBI because of the repair of intestinal damage. Conclusion: These findings suggest that the structural stability of FGF1 can contribute to the enhancement of protective effects against radiation-induced intestinal damage. Therefore, Q40P/S47I/H93G is pharmacologically one of the most promising candidates for clinical applications for radiation-induced gastrointestinal syndrome.

Nakayama, Fumiaki, E-mail: f_naka@nirs.go.jp [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Umeda, Sachiko [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Yasuda, Takeshi [Department of Radiation Emergency Medicine, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan)] [Department of Radiation Emergency Medicine, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan); Asada, Masahiro; Motomura, Kaori; Suzuki, Masashi [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan)] [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan); Zakrzewska, Malgorzata [Faculty of Biotechnology, University of Wroclaw (Poland)] [Faculty of Biotechnology, University of Wroclaw (Poland); Imamura, Toru [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan)] [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan); Imai, Takashi [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)

2013-02-01T23:59:59.000Z

109

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

incidence among atomic-bomb survivors Hiroshima and Nagasakiwith radiotherapy atomic bomb survivors in Hiroshima anddash line) large The hiroshima atomic bomb contained a

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

110

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

Japanese atomic bomb survivors in Hiroshima and Nagasaki,Japanese atomic bomb survivors in Hiroshima and Nagasaki (

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

111

EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION  

E-Print Network (OSTI)

atomic bomb survivors in Hiroshima and Nagasaki (17). Here, there is an age-atomic bomb survivors (17) and Marshall Islanders (18) exposed to nuclear explosions. Here, there is an age-

Fabrikant, J.I.

2010-01-01T23:59:59.000Z

112

Advisory Committee on human radiation experiments. Final report, Supplemental Volume 2. Sources and documentation  

SciTech Connect

This volume and its appendixes supplement the Advisory Committee`s final report by reporting how we went about looking for information concerning human radiation experiments and intentional releases, a description of what we found and where we found it, and a finding aid for the information that we collected. This volume begins with an overview of federal records, including general descriptions of the types of records that have been useful and how the federal government handles these records. This is followed by an agency-by-agency account of the discovery process and descriptions of the records reviewed, together with instructions on how to obtain further information from those agencies. There is also a description of other sources of information that have been important, including institutional records, print resources, and nonprint media and interviews. The third part contains brief accounts of ACHRE`s two major contemporary survey projects (these are described in greater detail in the final report and another supplemental volume) and other research activities. The final section describes how the ACHRE information-nation collections were managed and the records that ACHRE created in the course of its work; this constitutes a general finding aid for the materials deposited with the National Archives. The appendices provide brief references to federal records reviewed, descriptions of the accessions that comprise the ACHRE Research Document Collection, and descriptions of the documents selected for individual treatment. Also included are an account of the documentation available for ACHRE meetings, brief abstracts of the almost 4,000 experiments individually described by ACHRE staff, a full bibliography of secondary sources used, and other information.

NONE

1995-01-01T23:59:59.000Z

113

The study of human mutation rates  

SciTech Connect

We will describe recent developments regarding the question of induced mutations in the survivors of the atomic bombings of Hiroshima and Nagasaki. As part of that work we, describe some developments with respect to the Amerindian blood samples collected under DoE sponsorship between 1964 and 1982. Then developments regarding the application of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) to the study of genetic variation and mutation affecting protein characteristics. In particular, we will report on the identification and isolation of genes of especial interest as reflected in the behavior of the proteins which they encode.

Neel, J.V.

1992-01-01T23:59:59.000Z

114

Radiative Electron Capture Studied for Bare, Decelerated Uranium Th. Sthlker1,2  

E-Print Network (OSTI)

Radiative Electron Capture Studied for Bare, Decelerated Uranium Ions Th. St?hlker1,2 , X. Ma1,3 ,T the deceleration technique for bare uranium ions at the ESR storage ring we studied the Radiative Electron Capture in collisions of bare uranium ions with light target atoms at low beam energies. This allows us to extend our

115

Turbulence and Radiation in Stratocumulus Topped Marine Boundary Layers: A Case Study from VOCALS-REx  

Science Conference Proceedings (OSTI)

Observations made during a 24 hour period as part of the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx) are analyzed to study the radiation and turbulence associated with stratocumulus topped marine boundary layer (BL). ...

Virendra P. Ghate; Bruce A. Albrecht; Mark A. Miller; Alan Brewer; Christopher W. Fairall

116

Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease  

SciTech Connect

Purpose: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Methods and Materials: Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Results: Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +- 9.01 vs. 41.94 +- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +- 1303 vs. 1667 +- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +- 1084 vs. 1566 +- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.

Hu Shunying; Chen Yundai [Department of Cardiology, Chinese PLA General Hospital, Beijing (China); Li Libing [Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing (China); Chen Jinlong; Wu Bin [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Zhou, Xiao; Zhi Guang [Department of Cardiology, Chinese PLA General Hospital, Beijing (China); Li Qingfang; Wang Rongliang; Duan Haifeng; Guo Zikuan; Yang Yuefeng; Xiao Fengjun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Wang Hua, E-mail: wanghua@nic.bmi.ac.c [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China); Wang Lisheng [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing (China)

2009-12-01T23:59:59.000Z

117

Summary of radiation damage studies on rare earth permanent magnets  

SciTech Connect

With the proposed use of permanent magnets for both the NLC and the VLHC the issue flux loss due to radiation damage needs to be fully understood. There exist many papers on the subject. There are many difficulties in drawing conclusions from all of these data. First there is the difference methods of dosimetry, second different types of magnets and magnetic arrangements, and third different manufacturers of magnet material. This paper provides a summary of the existing literature on the subject.

J. T. Volk

2002-11-19T23:59:59.000Z

118

The children of parents exposed to atomic bombs: Estimates of the genetic doubling dose of radiation for humans  

SciTech Connect

The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice.

Neel, J.V.; Schull, W.J.; Awa, A.A.; Satoh, C.; Kato, H.; Otake, M.; Yoshimoto, Y. (Univ. of Michigan Medical School, Ann Arbor (USA))

1990-06-01T23:59:59.000Z

119

Radiation Protection Studies for LCLS Tune Up Dump  

Science Conference Proceedings (OSTI)

The Linac Coherent Light Source (LCLS) at the Stanford Linear Accelerator Center is a pioneer fourth generation hard x-ray free electron laser that shall start to deliver laser pulses in 2009. Among other components of LCLS that present radiation protection concerns, the tune up dump (tdund) is of special interest because it also constitutes an issue for machine protection, as it is placed close to radiation sensitive components, like electronic devices and permanent magnets in the undulators. This paper first introduces the stopper of tdund looking at the heat load, and then it describes the shielding around the dump necessary to maintain the prompt and residual dose within design values. Next, preliminary comparisons of the magnetization loss in a dedicated on-site magnet irradiation experiment with FLUKA simulations serve to characterize the magnetic response to radiation of magnets like those of LCLS. The previous knowledge, together with the limit for the allowed demagnetization, are used to estimate the lifetime of the undulator. Further simulations provide guidelines on which lifetime can be expected for an electronic device placed at a given distance of tdund.

Santana-Leitner, M.; Fass, A.; Mao, S.; Nuhn, H.D.; /SLAC; Roesler, S.; /CERN; Rokni, S.; Vollaire, J.; /SLAC

2010-04-29T23:59:59.000Z

120

LET dependence of radiation-induced bystander effects using human prostate tumor cells  

E-Print Network (OSTI)

In the past fifteen years, evidence provided by many independent research groups have indicated higher numbers of cells exhibiting damage than expected based on the number of cells traversed by the radiation. This phenomenon ...

Anzenberg, Vered

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Healthful LipidsChapter 12 CLA Sources and Human Studies  

Science Conference Proceedings (OSTI)

Healthful Lipids Chapter 12 CLA Sources and Human Studies Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry AOCS Press BE8A2AF8640552A5AF80E9DF60E25D15 AOCS Press Downloadable pdf ...

122

Estimates of Radiation Exposures for Human Crews in Deep Space from the January 15, 2005, Solar Energetic Particle Event Using the Earth-Moon-Mars Radiation Environment Module  

Science Conference Proceedings (OSTI)

Technical Paper / Special Issue on the 16th Biennial Topical Meeting of the Radiation Protection and Shielding Division / Radiation Transport and Protection

Mahmoud PourArsalan; Lawrence W. Townsend; Nathan A. Schwadron; Kamen Kozarev; Maher A. Dayeh; Mihir I. Desai

123

THE NATIONAL CENTER FOR RADIOECOLOGY: A NETWORK OF EXCELLENCE FOR ENVIRONMENTAL AND HUMAN RADIATION RISK REDUCTION  

SciTech Connect

Radioecology in the United States can be traced back to the early 1950s when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a graduate education training program for radioecology. Recently, NCoRE hosted a workshop to identify the immediate needs for science-driven discoveries, tool development and the generation of scientific data to support the legislative decision-making process for remediation strategies, long-term monitoring of radiologically-contaminated sites and protection of human health and the environment. Some of the immediate strategic research needs were identified in the fields of functional genomics for determining low-dose effects, improved low-level dosimetry, and mixed (radiological and chemical) contaminant studies. Longer term strategic research and tool development areas included development of radioecology case study sites, comprehensive decision-making tools, consequence response actions, and optimized scenario based ecosystem modeling. A summary of the NCoRE workshop findings related to waste management needs and priority areas will be presented in this paper.

Jannik, T.

2013-01-09T23:59:59.000Z

124

In Situ Study of Radiation Damage in Pure Zr and Zircaloy-2  

Science Conference Proceedings (OSTI)

Presentation Title, In Situ Study of Radiation Damage in Pure Zr and Zircaloy-2 ... cascades at the early stages of damage development at very low dose (0.01...

125

Study of Radiative and Turbulent Processes in the Stable Boundary Layer under Weak Wind Conditions  

Science Conference Proceedings (OSTI)

The role of radiation and turbulence was studied in a weak wind nocturnal inversion layer using a one-dimensional model. In contrast to a strong wind stable boundary layer where cooling within the surface inversion layer is dominated by ...

S. G. Gopalakrishnan; Maithili Sharan; R. T. McNider; M. P. Singh

1998-03-01T23:59:59.000Z

126

Radiation Tolerance Studies of BTeV Pixel Readout Chip Prototypes  

Science Conference Proceedings (OSTI)

We report on several irradiation studies performed on BTeV preFPIX2 pixel readout chip prototypes exposed to a 200 MeV proton beam at the Indiana University Cyclotron Facility. The preFPIX2 pixel readout chip has been implemented in standard 0.25 micron CMOS technology following radiation tolerant design rules. The tests confirmed the radiation tolerance of the chip design to proton total dose of 26 MRad. In addition, non destructive radiation-induced single event upsets have been observed in on-chip static registers and the single bit upset cross section has been measured.

Gabriele Chiodini et al.

2001-09-11T23:59:59.000Z

127

Preliminary Studies on the Variational Assimilation of Cloud-Radiation Observations Using ARM Observations  

NLE Websites -- All DOE Office Websites (Extended Search)

Studies on the Variational Assimilation Studies on the Variational Assimilation of Cloud-Radiation Observations Using ARM Observations M. Janisková, J.-F. Mahfouf, and J.-J. Morcrette European Centre for Medium-Range Weather Forecasts Shinfield Park, Reading Berskshire, United Kingdom Abstract A linearized cloud scheme and a radiation scheme including cloud effects have been developed at European Centre for Medium-Range Weather Forecasts (ECMWF) to assimilate cloud properties in the framework of the four-dimensional variational (4D-Var) assimilation system. To investigate the potential of those schemes to modify the model temperature, humidity and cloud profiles and produce a better match to the observed radiation fluxes, one-dimensional variational (1D-Var) assimilation experiments have been carried out using data from the Atmospheric Radiation Measurement (ARM)

128

Importance of Accurate Liquid Water Path for Estimation of Solar Radiation in Warm Boundary Layer Clouds: An Observational Study  

Science Conference Proceedings (OSTI)

A 1-yr observational study of overcast boundary layer stratus at the U.S. Department of Energy Atmospheric Radiation Measurement Program Southern Great Plains site illustrates that surface radiation has a higher sensitivity to cloud liquid water ...

Manajit Sengupta; Eugene E. Clothiaux; Thomas P. Ackerman; Seiji Kato; Qilong Min

2003-09-01T23:59:59.000Z

129

Health Risks Associated with Low Doses of Radiation  

Science Conference Proceedings (OSTI)

Despite a wealth of information, there remains uncertainty concerning human radiation effects at low dose levels. This report provides background information and a literature review of research on the potential health hazards associated with exposure to low-level ionizing radiation. Topics include radiation characteristics, protection standards, epidemiologic data and risk models, the nature of human health exposure-related effects, important radiation health studies to date, and the scientific method fo...

1994-09-17T23:59:59.000Z

130

Contribution of radiation damage to the study of basic atomic motion in solids  

SciTech Connect

Radiation damage is a powerful tool for the study of point-defect interactions in solids. The large numbers of point defects produced during irradiation and subsequent annealing aggregate to form planar and linear defects. A study of the nature of these defects provides basic understanding of the mechanics of defect formation in solids. Defects in ion-bombarded silicon are studied using the transmission electron microscope. A mechanism for the formation of the observed defects is proposed. The utility of radiation damage studies in the understanding of atom motion in solids is demonstrated. (auth)

Seshan, K.

1973-02-01T23:59:59.000Z

131

Low Dose Radiation Research Program: Real-Time Molecular Study...  

NLE Websites -- All DOE Office Websites (Extended Search)

Real-Time Molecular Study of Bystander Effects Using Imaging and Nano-Particle Optics Mohan Natarajan University of Texas Health Science Center Why this Project? To develop...

132

Radiation-cooled Dew Water Condensers Studied by Computational Fluid Dynamic (CFD)  

E-Print Network (OSTI)

Harvesting condensed atmospheric vapour as dew water can be an alternative or complementary potable water resource in specific arid or insular areas. Such radiation-cooled condensing devices use already existing flat surfaces (roofs) or innovative structures with more complex shapes to enhance the dew yield. The Computational Fluid Dynamic - CFD - software PHOENICS has been programmed and applied to such radiation cooled condensers. For this purpose, the sky radiation is previously integrated and averaged for each structure. The radiative balance is then included in the CFD simulation tool to compare the efficiency of the different structures under various meteorological parameters, for complex or simple shapes and at various scales. It has been used to precise different structures before construction. (1) a 7.32 m^2 funnel shape was studied; a 30 degree tilted angle (60 degree cone half-angle) was computed to be the best compromise for funnel cooling. Compared to a 1 m^2 flat condenser, the cooling efficienc...

Clus, O; Muselli, M; Nikolayev, Vadim; Sharan, Girja; Beysens, D

2007-01-01T23:59:59.000Z

133

Lawrence Livermore study finds human activity affects vertical...  

NLE Websites -- All DOE Office Websites (Extended Search)

human activity affects vertical structure of atmospheric temperature Anne M Stark, LLNL, (925) 422-9799, stark8@llnl.gov Human influences have directly impacted the latitude...

134

Mutation, radiation, and species survival: The genetics studies of the Atomic Bomb Casualty Commission in Hiroshima and Nagasaki, Japan  

SciTech Connect

This is an analysis of the work of the Atomic Bomb Casualty Commission, an American agency which studied the effects of radiation on survivors of the atomic bombings at Hiroshima and Nagasaki, Japan, 1947-1975. Funded by the U.S. Atomic Energy Commission and directed by the National Academy of Sciences-National Research Council, the ABCC was the largest and longest medical study of the estimated 300,000 survivors. The morphological genetics study dominated the ABCCs first decade. James Neel and his principal collaborator William J. Schull tracked more than 76,000 pregnancies. Their results (1956) suggested the bombs radiation had no detectable impact on the offspring of survivors. Though geneticists knew that radiation caused heritable mutations in experimental organisms such as Drosophila, and believed it caused mutations in humans, the Neel-Schull findings were not a surprise. The practical difficulties of the study, and the relatively small increase in abnormal births to be expected, made a finding of significant effects unlikely. The Neel-Schull approach reflected the scientific debate over genetic load, and the Muller-Dobzhansky classical-balance controversy. Yet the findings also reflected the post-war debate over atomic energy and weapons testing. Many extra-scientific forces militated against a finding of positive effects at Hiroshima and Nagasaki. Negative findings were consistent with the needs of the Atomic Energy Commission, the State Department and the U.S. military. This dissertation explores how both the scientific debate about genetic load, and the political debate about atmospheric weapons testing, shaped this complex epidemiological study.

Lindee, M.S.

1990-01-01T23:59:59.000Z

135

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

SciTech Connect

Human mesenchymal stem cells (hMSC) are critical for tissue regeneration. How hMSC respond to genotoxic stresses and potentially contribute to aging and cancer remain underexplored. We demonstrated that ionizing radiation induced cellular senescence of hMSC over a period of 10 days, showing a critical transition between day 3 and day 6. This was confirmed by senescence-associated beta-galactosidase (SA-{beta}-gal) staining, protein expression profiles of key cell cycle regulators (retinoblastoma (Rb) protein, p53, p21{sup waf1/Cip1}, and p16{sup INK4A}), and senescence-associated secretory phenotypes (SASPs) (IL-8, IL-12, GRO, and MDC). We observed dramatic cytoskeletal reorganization of hMSC through reduction of myosin-10, redistribution of myosin-9, and secretion of profilin-1. Using a SILAC-based phosphoproteomics method, we detected significant reduction of myosin-9 phosphorylation at Ser1943, coinciding with its redistribution. Importantly, through treatment with cell permeable inhibitors (4,5,6,7-tetrabromo-1H-benzotriazole (TBB) and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT)), and gene knockdown using RNA interference, we identified CK2, a kinase responsible for myosin-9 phosphorylation at Ser1943, as a key factor contributing to the radiation-induced senescence of hMSC. We showed that individual knockdown of CK2 catalytic subunits CK2{alpha} and CK2{alpha}{prime} induced hMSC senescence. However, only knockdown of CK2{alpha} resulted in morphological phenotypes resembling those of radiation-induced senescence. These results suggest that CK2{alpha} and CK2{alpha}{prime} play differential roles in hMSC senescence progression, and their relative expression might represent a novel regulatory mechanism for CK2 activity.

Wang, Daojing; Jang, Deok-Jin

2009-08-21T23:59:59.000Z

136

A Prospective Cohort Study on Radiation-induced Hypothyroidism: Development of an NTCP Model  

Science Conference Proceedings (OSTI)

Purpose: To establish a multivariate normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism. Methods and Materials: The thyroid-stimulating hormone (TSH) level of 105 patients treated with (chemo-) radiation therapy for head-and-neck cancer was prospectively measured during a median follow-up of 2.5 years. Hypothyroidism was defined as elevated serum TSH with decreased or normal free thyroxin (T4). A multivariate logistic regression model with bootstrapping was used to determine the most important prognostic variables for radiation-induced hypothyroidism. Results: Thirty-five patients (33%) developed primary hypothyroidism within 2 years after radiation therapy. An NTCP model based on 2 variables, including the mean thyroid gland dose and the thyroid gland volume, was most predictive for radiation-induced hypothyroidism. NTCP values increased with higher mean thyroid gland dose (odds ratio [OR]: 1.064/Gy) and decreased with higher thyroid gland volume (OR: 0.826/cm{sup 3}). Model performance was good with an area under the curve (AUC) of 0.85. Conclusions: This is the first prospective study resulting in an NTCP model for radiation-induced hypothyroidism. The probability of hypothyroidism rises with increasing dose to the thyroid gland, whereas it reduces with increasing thyroid gland volume.

Boomsma, Marjolein J.; Bijl, Hendrik P.; Christianen, Miranda E.M.C.; Beetz, Ivo; Chouvalova, Olga; Steenbakkers, Roel J.H.M. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Laan, Bernard F.A.M. van der [Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Wolffenbuttel, Bruce H.R. [Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Oosting, Sjoukje F. [Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Schilstra, Cornelis [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Langendijk, Johannes A., E-mail: j.a.langendijk@umcg.nl [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

2012-11-01T23:59:59.000Z

137

Radiation Damage Study in Natural Zircon Using Neutrons Irradiation  

Science Conference Proceedings (OSTI)

Changes of atomic displacements in crystalline structure of natural zircon (ZrSiO{sub 4}) can be studied by using neutron irradiation on the surface of zircon and compared the data from XRD measurements before and after irradiation. The results of neutron irradiation on natural zircon using Pneumatic Transfer System (PTS) at PUSPATI TRIGA Research Reactor in the Malaysian Nuclear Agency are discussed in this work. The reactor produces maximum thermal power output of 1 MWatt and the neutron flux of up to 1x10{sup 13} ncm{sup -2}s{sup -1}. From serial decay processes of uranium and thorium radionuclides in zircon crystalline structure, the emission of alpha particles can produce damage in terms of atomic displacements in zircon. Hence, zircon has been extensively studied as a possible candidate for immobilization of fission products and actinides.

Lwin, Maung Tin Moe; Amin, Yusoff Mohd.; Kassim, Hasan Abu [Department of Physics, University of Malaya, 50603 Kuala Lumpur (Malaysia); Mohamed, Abdul Aziz [Materials Technology Group, Industrial Technology Division, Malaysian Nuclear Agency Bangi, 43000 Kajang, Selangor Darul Ehsan (Malaysia); Karim, Julia Abdul [Reactor Physics Section, Nuclear Power Division, Malaysian Nuclear Agency Bangi, 43000 Kajang, Selangor Darul Ehsan (Malaysia)

2011-03-30T23:59:59.000Z

138

Experimental Studies on Coherent Synchrotron Radiation at an Emittance Exchange Beamline  

SciTech Connect

One of the goals of the Fermilab A0 photoinjector is to experimentally investigate the transverse to longitudinal emittance exchange (EEX) principle. Coherent synchrotron radiation in the emittance exchange line could limit the performance of the emittance exchanger at short bunch lengths. In this paper, we present experimental and simulation studies of the coherent synchrotron radiation (CSR) in the emittance exchange line at the A0 photoinjector. We report on time-resolved CSR studies using a skew-quadrupole technique. We also demonstrate the advantages of running the EEX with an energy chirped beam.

Thangaraj, J.C.T.; Thurman-Keup, R.; Ruan, J.; Johnson, A.S.; Lumpkin, A.H.; Santucci, J.; /Fermilab

2012-04-01T23:59:59.000Z

139

Environmental radiation protection studies related to nuclear industries, using AMS  

Science Conference Proceedings (OSTI)

14 C is produced in nuclear reactors during normal operation and part of it is continuously released into the environment. Because of the biological importance of carbon and the long physical half-life of 14 C it is of interest to study these releases. The 14 C activity concentrations in the air and vegetation around some Swedish as well as foreign nuclear facilities have been measured by accelerator mass spectrometry (AMS). 59 Ni is produced by neutron activation in the stainless steel close to the core of a nuclear reactor. The 59 Ni levels have been measured in order to be able to classify the different parts of the reactor with respect to their content of long-lived radionuclides before final storage. The technique used to measure 59 Ni at a small accelerator such as the Lund facility has been developed over the past few years and material from the Swedish nuclear industry has been analyzed.

Ragnar Hellborg; Bengt Erlandsson; Mikko Faarinen; Helena Hkansson; Kjell Hkansson; Madis Kiisk; Carl-Erik Magnusson; Per Persson; Gran Skog; Kristina Stenstrm; Sren Mattsson; Charlotte Thornberg

2001-01-01T23:59:59.000Z

140

Neutron measurements and radiation damage calculations for fusion materials studies  

SciTech Connect

Fusion reactors will generate intense neutron fields, especially at the inner surfaces of containment vessels. With a typical wall loading of 1 MW/m/sup 2/, the yearly neutron fluence will be about 10/sup 26/ n/m/sup 2/. In a material like stainless steel this irradiation will produce about 10 atomic displacements-per-atom (DPA), 100 appM helium, 500 appM hydrogen, and various other transmutations. The gas-to-DPA ratios are very high compared to fission reactors due to the 14 MeV neutrons from the d-t fusion reaction. No existing neutron source can produce both the high fluence and high gas rates needed to simulate fusion damage. Consequently, fusion material studies are underway in a variety of facilities including fission reactors and accelerator-based neutron sources. A Subtask Group has been created by DOE to characterize these diverse facilities in terms of neutron flux and energy spectrum and to calculate DPA and transmutation for specific irradiations. Material property changes can then be correlated between facilities and extrapolated to fusion reactor conditions.

Greenwood, L.R.

1983-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Radiation Tolerant Metallic Multilayers  

Science Conference Proceedings (OSTI)

Strategies that can alleviate radiation damage may assist the design of radiation tolerant materials. We will summarize our recent studies on radiation damage in...

142

Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study  

Science Conference Proceedings (OSTI)

Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates, for example medical diagnostic procedures, may be overestimated by such risk models, but data for humans to examine this issue are limited. In this paper we report on lung cancer mortality between 1950 and 1987 in a cohort of 64,172 Canadian tuberculosis patients, of whom 39% were exposed to highly fractionated multiple chest fluoroscopies leading to a mean lung radiation dose of 1.02 Sv received at moderate dose rates. These data have been used to estimate the excess relative risk per sievert of lung cancer mortality, and this is compared directly to estimates derived from 75,991 atomic bomb survivors. Based on 1,178 lung cancer deaths in the fluoroscopy study, there was no evidence of any positive association between risk and dose, with the relative risk at 1 Sv being 1.00 (95% confidence interval 0.94, 1.07), which contrasts with that based on the atomic bomb survivors, 1.60 (1.27, 1.99). The difference in effect between the two studies almost certainly did not arise by chance (P = 0.0001). This study provides strong support from data for humans for a substantial fractionation/dose-rate effect for low-linear energy transfer radiation and lung cancer risk. This implies that lung cancer risk from exposures to such radiation at present-day dose rates is likely to be lower than would be predicted by current radiation risk models based on studies of high-dose-rate exposures. 25 refs., 8 tabs.

Howe, G.R. [Univ. of Toronto, Ontario (Canada)

1995-06-01T23:59:59.000Z

143

Quantitative Ultrasonic Evaluation of Radiation-Induced Late Tissue Toxicity: Pilot Study of Breast Cancer Radiotherapy  

Science Conference Proceedings (OSTI)

Purpose: To investigate the use of advanced ultrasonic imaging to quantitatively evaluate normal-tissue toxicity in breast-cancer radiation treatment. Methods and Materials: Eighteen breast cancer patients who received radiation treatment were enrolled in an institutional review board-approved clinical study. Radiotherapy involved a radiation dose of 50.0 to 50.4 Gy delivered to the entire breast, followed by an electron boost of 10.0 to 16.0 Gy delivered to the tumor bed. Patients underwent scanning with ultrasound during follow-up, which ranged from 6 to 94 months (median, 22 months) postradiotherapy. Conventional ultrasound images and radio-frequency (RF) echo signals were acquired from treated and untreated breasts. Three ultrasound parameters, namely, skin thickness, Pearson coefficient, and spectral midband fit, were computed from RF signals to measure radiation-induced changes in dermis, hypodermis, and subcutaneous tissue, respectively. Ultrasound parameter values of the treated breast were compared with those of the untreated breast. Ultrasound findings were compared with clinical assessment using Radiation Therapy Oncology Group (RTOG) late-toxicity scores. Results: Significant changes were observed in ultrasonic parameter values of the treated vs. untreated breasts. Average skin thickness increased by 27.3%, from 2.05 {+-} 0.22mm to 2.61 {+-} 0.52mm; Pearson coefficient decreased by 31.7%, from 0.41 {+-} 0.07 to 0.28 {+-} 0.05; and midband fit increased by 94.6%, from -0.92 {+-} 7.35 dB to 0.87 {+-} 6.70 dB. Ultrasound evaluations were consistent with RTOG scores. Conclusions: Quantitative ultrasound provides a noninvasive, objective means of assessing radiation-induced changes to the skin and subcutaneous tissue. This imaging tool will become increasingly valuable as we continue to improve radiation therapy technique.

Liu Tian, E-mail: tliu34@emory.ed [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States); Zhou Jun [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Yoshida, Emi J. [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States); Woodhouse, Shermian A. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Schiff, Peter B. [Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA (United States); Wang, Tony J.C. [Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Lu Zhengfeng; Pile-Spellman, Eliza [Department of Radiology, Columbia University Medical Center, New York, NY (United States); Zhang Pengpeng [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Kutcher, Gerald J. [Department of History, Binghamton University, Binghamton, NY (United States)

2010-11-01T23:59:59.000Z

144

Carbonaceous Aerosols and Radiative Effects Study (CARES), g1-aircraft, sedlacek sp2  

DOE Data Explorer (OSTI)

The primary objective of the Carbonaceous Aerosol and Radiative Effects Study (CARES) in 2010 was to investigate the evolution of carbonaceous aerosols of different types and their optical and hygroscopic properties in central California, with a focus on the Sacramento urban plume.

Art Sedlacek

145

Carbonaceous Aerosols and Radiative Effects Study (CARES), g1-aircraft, sedlacek sp2  

Science Conference Proceedings (OSTI)

The primary objective of the Carbonaceous Aerosol and Radiative Effects Study (CARES) in 2010 was to investigate the evolution of carbonaceous aerosols of different types and their optical and hygroscopic properties in central California, with a focus on the Sacramento urban plume.

Art Sedlacek

2011-08-30T23:59:59.000Z

146

Computational study of atmospheric transfer radiation on an equatorial tropical desert (La Tatacoa, Colombia)  

E-Print Network (OSTI)

Radiative transfer models explain and predict interaction between solar radiation and the different elements present in the atmosphere, which are responsible for energy attenuation. In Colombia there have been neither measurements nor studies of atmospheric components such as gases and aerosols that can cause turbidity and pollution. Therefore satellite images cannot be corrected radiometrically in a proper way. When a suitable atmospheric correction is carried out, loss of information is avoided, which may be useful for discriminating image land cover. In this work a computational model was used to find radiative atmospheric attenuation (300 1000nm wavelength region) on an equatorial tropical desert (La Tatacoa, Colombia) in order to conduct an adequate atmospheric correction.

Delgado-Correal, Camilo; Castao, Gabriel

2012-01-01T23:59:59.000Z

147

A Theoretical Study of the Magnetic Structure of Bulk Iron with Radiation Defects  

SciTech Connect

A fundamental understanding of the radiation damage effects in solids is of great importance in assisting the development of improved materials with ultra-high strength, toughness, and radiation resistance for nuclear energy applications. In this presentation, we show our recent theoretical investigation on the magnetic structure evolution of bulk iron in the region surrounding the radiation defects. We applied the locally self-consistent multiple scattering method (LSMS), a linear scaling ab-initio method based on density functional theory with local spin density approximation, to the study of the magnetic structure in a low energy cascade in a 10,000-atom sample for a series of time steps for the evolution of the defects. The primary damage state and the evolution of all defects in the sample were simulated using molecular dynamics with empirical, embedded-atom inter-atomic potentials. We also discuss the importance of thermal effect on the magnetic structure evolution.

Wang, Yang [Pittsburgh Supercomputing Center; Stoller, Roger E [ORNL; Rusanu, Aurelian [ORNL; Nicholson, Don M [ORNL; Eisenbach, Markus [ORNL; Stocks, George Malcolm [ORNL

2011-01-01T23:59:59.000Z

148

Modeling aspects of human memory for scientific study.  

Science Conference Proceedings (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

149

Chronic Low Dose Radiation Effects on Radiation Sensitivity  

NLE Websites -- All DOE Office Websites (Extended Search)

Chronic Low Dose Radiation Effects on Radiation Sensitivity Chronic Low Dose Radiation Effects on Radiation Sensitivity and Chromosome Instability Induction in TK6 Cells Schwartz J.L. 1 , Jordan R. 1 , Slovic J. 1 , Moruzzi A. 1 , Kimmel R. 2 , and Liber, H.L. 3 1 University of Washington, Seattle, WA; 2 Fred Hutchinson Cancer Research Center, Seattle, WA; 3 Colorado State University, Fort Collins, Colorado There are a number of cell responses that can be detected after low dose radiation exposures including the adaptive response, low dose hypersensitivity, and induced genomic instability. The relationship between these different phenomena is unknown. In this study, we measured adaptive responses, low dose hypersensitivity, and induced genomic instability in a human B-lymphoblastoid cell model, TK6, where we could genetically modify radiation responses by either over-expression of BCL-2 or deletion of TP53. TK6

150

Building Public Trust - Actions to Respond to the Report of the Advisory Committee on Human Radiation Experiments  

NLE Websites -- All DOE Office Websites (Extended Search)

Part 1: Openness in Government Part 1: Openness in Government Part 1: Openness in Government ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Overview Throughout our nation's history, the government has needed to operate with some secrecy to protect our nation's security. At the same time, Americans have recognized that the government's power to act in secret conflicts with core democratic principles. Misuse of secrecy feeds a sense of mistrust in government that can undermine our cohesion as a nation. During the Cold War, the government funded human radiation experiments, some of which were secret. It is imperative that the public have access to the record of the government's activities. The

151

A Study of Fitting the Generalized Lambda Distribution to Solar Radiation Data  

Science Conference Proceedings (OSTI)

The increased interest in the climatology of solar radiation dictates a need for a distribution to fit daily solar radiation totals which tend to have negatively-skewed probability distributions. Even daily mean solar radiation for weekly periods ...

A. ztrk; R. F. Dale

1982-07-01T23:59:59.000Z

152

Humans, Robots and Market Crashes: A Laboratory Study ?  

E-Print Network (OSTI)

Du?y, J. (2006). Agent-Based Models and Human SubjectFinancial markets, agent-based models, experimentalIn response, several agent-based models have been proposed.

Feldman, Todd; Friedman, Daniel

2008-01-01T23:59:59.000Z

153

Structural studies of the human polymeric immunoglobulin receptor  

E-Print Network (OSTI)

The human polymeric immunoglobulin receptor, pIgR, is a glycosylated type I transmembrane protein expressed on the basolateral surface of secretory epithelial cells. pIgR plays a key role in mucosal immunity and, together ...

Hamburger, Agnes Eva, 1976-

2005-01-01T23:59:59.000Z

154

Automatic segmentation of human facial tissue by MRI-CT fusion: A feasibility study  

Science Conference Proceedings (OSTI)

The aim of this study was to develop automatic image segmentation methods to segment human facial tissue which contains very thin anatomic structures. The segmentation output can be used to construct a more realistic human face model for a variety of ... Keywords: Bayesian, Data fusion, Human facial tissue, Level Sets, Medical image segmentation, Partial volume

Emre H. Kale; Erkan U. Mumcuoglu; Salih Hamcan

2012-12-01T23:59:59.000Z

155

Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005  

SciTech Connect

As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

Gayle Woloschak

2009-12-16T23:59:59.000Z

156

POLARIZATION STUDIES OF CdZnTe DETECTORS USING SYNCHROTRON X-RAY RADIATION.  

Science Conference Proceedings (OSTI)

New results on the effects of small-scale defects on the charge-carrier transport in single-crystal CdZnTe (CZT) material were produced. We conducted detailed studies of the role of Te inclusions in CZT by employing a highly collimated synchrotron x-ray radiation source available at Brookhaven's National Synchrotron Light Source (NSLS). We were able to induce polarization effects by irradiating specific areas with the detector. These measurements allowed the first quantitative comparison between areas that are free of Te inclusions and those with a relatively high concentration of inclusions. The results of these polaration studies will be reported.

CAMARDA,G.S.; BOLOTNIKOV, A.E.; CUI, Y.; HOSSAIN, A.; JAMES, R.B.

2007-07-01T23:59:59.000Z

157

Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells  

Science Conference Proceedings (OSTI)

In a pilot study to detect the potential effects of atomic bomb radiation on germ-line instability, we screened 64 children from 50 exposed families and 60 from 50 control families for mutations at six minisatellite loci by using Southern blot analysis with Pc-1, {lambda}TM-18, ChdTC-15, p{lambda}g3, {lambda}MS-1, and CEB-1 probes. In the exposed families, one or both parents received a radiation dose >0.01 Sv. Among the 64 children, only one child had parents who were both exposed. Thus, of a total of 128 gametes that produced the 64 children, 65 gametes were derived from exposed parents and 63 were from unexposed parents, the latter being included in a group of 183 unexposed gametes used for calculating mutation rates. The average parental gonadal dose for the 65 gametes was 1.9 Sv. We detected a total of 28 mutations at the p{lambda}g3, {lambda}MS-1, and CEB-1 loci, but no mutations at the Pc-1, {lambda}TM-18, and ChdTC-15 loci. We detected 6 mutations in 390 alleles of the 65 exposed gametes and 22 mutations in 1098 alleles of the 183 gametes from the unexposed parents. The mean mutation rate per locus per gamete in these six minisatellite loci was 1.5% in the exposed parents and 2.0% in the unexposed parents. We observed no significant difference in mutation rates in the children of the exposed and the unexposed parents (P = .37, Fisher`s exact probability test). 38 refs., 1 fig., 5 tabs.

Kodaira, Mieko; Satoh, Chiyoko [Radiation Effects Research Foundation, Hiroshima (Japan); Hiyama, Keiko [Radiation Effects Research Foundation, Hiroshima (Japan)]|[Hiroshima Univ. School of Medicine (Japan)] [and others

1995-12-01T23:59:59.000Z

158

EPRI-CRIEPI Joint Human Factors Program Summary Report: Joint EPRI-CRIEPI Human Factors Studies  

Science Conference Proceedings (OSTI)

The EPRI-CRIEPI Joint Human Factors Program developed an array of intervention products that provide logical solutions to performance problems confronting nuclear power plant maintenance workers. These products, designed to reduce the incidence of errors and increase productivity, range from job performance cards to a software-based authoring system for training material.

1995-01-24T23:59:59.000Z

159

Cancer risk among atomic bomb survivors. The RERF Life Span Study. Radiation Effects Research Foundation  

SciTech Connect

This article summarizes the risk of cancer among the survivors of the atomic bombing of Hiroshima and Nagasaki. We focus primarily on the risk of death from cancer among individuals in the Life Span Study sample of the Radiation Effects Research Foundation from 1950 through 1985 based on recently revised dosimetry procedures. We report the risk of cancer other than leukemia among the atomic bomb survivors. We note that the number of excess deaths of radiation-induced malignant tumors other than leukemia increases with age. Survivors who were exposed in the first or second decade of life have just entered the cancer-prone age and have so far exhibited a high relative risk in association with radiation dose. Whether the elevated risk will continue or will fall with time is not yet clear, although some evidence suggests that the risk may be declining. It is important to continue long-term follow-up of this cohort to document the changes with time since exposure and to provide direct rather than projected risks over the lifetime of an exposed individual.

Shimizu, Y.; Schull, W.J.; Kato, H. (Radiation Effects Research Foundation, Hiroshima (Japan))

1990-08-01T23:59:59.000Z

160

Analytical and experimental studies of heat pipe radiation cooling of hypersonic propulsion systems  

SciTech Connect

Preliminary, research-oriented, analytical and experimental studies were completed to assess the feasibility of using high-temperature heat pipes to cool hypersonic engine components. This new approach involves using heat pipes to transport heat away from the combustor, nozzle, or inlet regions, and to reject it to the environment by thermal radiation from an external heat pipe nacelle. For propulsion systems using heat pipe radiation cooling (HPRC), it is possible to continue to use hydrocarbon fuels into the Mach 4 to Mach 6 speed range, thereby enhancing the economic attractiveness of commercial or military hypersonic flight. In the second-phase feasibility program recently completed, we found that heat loads produced by considering both convection and radiation heat transfer from the combustion gas can be handled with HPRC design modifications. The application of thermal insulation to ramburner and nozzle walls was also found to reduce the heat load by about one-half and to reduce peak HPRC system temperatures to below 2700{degrees}F. In addition, the operation of HPRC at cruise conditions of around Mach 4.5 and at an altitude of 90, 000 ft lowers peak hot section temperatures to around 2800{degrees}F. An HPRC heat pipe was successfully fabricated and tested at Mach 5 conditions of heat flux, heat load, and temperature. 24 refs.

Martin, R.A.; Merrigan, M.A.; Elder, M.G.; Sena, J.T.; Keddy, E.S. (Los Alamos National Lab., NM (United States)); Silverstein, C.C. (CCS Associates, Bethel Park, PA (United States))

1992-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Analytical and experimental studies of heat pipe radiation cooling of hypersonic propulsion systems  

SciTech Connect

Preliminary, research-oriented, analytical and experimental studies were completed to assess the feasibility of using high-temperature heat pipes to cool hypersonic engine components. This new approach involves using heat pipes to transport heat away from the combustor, nozzle, or inlet regions, and to reject it to the environment by thermal radiation from an external heat pipe nacelle. For propulsion systems using heat pipe radiation cooling (HPRC), it is possible to continue to use hydrocarbon fuels into the Mach 4 to Mach 6 speed range, thereby enhancing the economic attractiveness of commercial or military hypersonic flight. In the second-phase feasibility program recently completed, we found that heat loads produced by considering both convection and radiation heat transfer from the combustion gas can be handled with HPRC design modifications. The application of thermal insulation to ramburner and nozzle walls was also found to reduce the heat load by about one-half and to reduce peak HPRC system temperatures to below 2700{degrees}F. In addition, the operation of HPRC at cruise conditions of around Mach 4.5 and at an altitude of 90, 000 ft lowers peak hot section temperatures to around 2800{degrees}F. An HPRC heat pipe was successfully fabricated and tested at Mach 5 conditions of heat flux, heat load, and temperature. 24 refs.

Martin, R.A.; Merrigan, M.A.; Elder, M.G.; Sena, J.T.; Keddy, E.S. [Los Alamos National Lab., NM (United States); Silverstein, C.C. [CCS Associates, Bethel Park, PA (United States)

1992-06-01T23:59:59.000Z

162

A study of radiation damage effects on the magnetic structure of bulk Iron  

SciTech Connect

Defects, defect interactions, and defect dynamics in solids created by fast neutrons are known to have significant impact on the performance and lifetime of structural materials. A fundamental understanding of the radiation damage effects in solids is therefore of great importance in assisting the development of improved materials - materials with ultrahigh strength, toughness, and radiation resistance. In this presentation, we show our recent theoretical investigation on the magnetic structure evolution of bulk iron in the region of the radiation defects. We applied a linear scaling ab-initio method based on density functional theory with local spin density approximation, namely the locally self-consistent multiple scattering method (LSMS), to the study of magnetic moment distributions in a cascade at the damage peak and for a series of time steps as the interstitials and vacancies recombined. Atomic positions correspond to those in a low energy cascade in a 10|000 atom sample, in which the primary damage state and the evolution of all defects produced were simulated using molecular dynamics with empirical, embedded-atom inter-atomic potentials. We will discuss how a region of affected moments expands and then recedes in response to a cascade evolution.

Wang Yang [Pittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 (United States); Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States); Nicholson, D. M. C.; Stocks, G. M.; Rusanu, Aurelian; Eisenbach, Markus; Stoller, R. E. [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 (United States)

2011-04-01T23:59:59.000Z

163

A study of radiation damage effects on the magnetic structure of bulk Iron  

Science Conference Proceedings (OSTI)

Defects, defect interactions, and defect dynamics in solids created by fast neutrons are known to have significant impact on the performance and lifetime of structural materials. A fundamental understanding of the radiation damage effects in solids is therefore of great importance in assisting the development of improved materials - materials with ultrahigh strength, toughness, and radiation resistance. In this presentation, we show our recent theoretical investigation on the magnetic structure evolution of bulk iron in the region of the radiation defects. We applied a linear scaling ab-initio method based on density functional theory with local spin density approximation, namely the locally self-consistent multiple scattering method (LSMS), to the study of magnetic moment distributions in a cascade at the damage peak and for a series of time steps as the interstitials and vacancies recombined. Atomic positions correspond to those in a low energy cascade in a 10|000 atom sample, in which the primary damage state and the evolution of all defects produced were simulated using molecular dynamics with empirical, embedded-atom inter-atomic potentials. We will discuss how a region of affected moments expands and then recedes in response to a cascade evolution. VC 2011 American Institute of Physics. [doi:10.1063/1.3553937

Wang, Yang Nmn [ORNL; Nicholson, Don M [ORNL; Stocks, George Malcolm [ORNL; Rusanu, Aurelian [ORNL; Eisenbach, Markus [ORNL; Stoller, Roger E [ORNL

2011-01-01T23:59:59.000Z

164

A study of radiation damage effects on the magnetic structure of bulk Iron  

Science Conference Proceedings (OSTI)

Defects, defect interactions, and defect dynamics in solids created by fast neutrons are known to have significant impact on the performance and lifetime of structural materials. A fundamental understanding of the radiation damage effects in solids is therefore of great importance in assisting the development of improved materials - materials with ultrahigh strength, toughness, and radiation resistance. In this presentation, we show our recent theoretical investigation on the magnetic structure evolution of bulk iron in the region of the radiation defects. We applied a linear scaling ab-initio method based on density functional theory with local spin density approximation, namely the locally self-consistent multiple scattering method (LSMS), to the study of magnetic moment distributions in a cascade at the damage peak and for a series of time steps as the interstitials and vacancies recombined. Atomic positions correspond to those in a low energy cascade in a 10|000 atom sample, in which the primary damage state and the evolution of all defects produced were simulated using molecular dynamics with empirical, embedded-atom inter-atomic potentials. We will discuss how a region of affected moments expands and then recedes in response to a cascade evolution.

Wang, Yang [Pittsburgh Supercomputing Center; Stocks, George Malcolm [ORNL; Stoller, Roger E [ORNL; Nicholson, Don M [ORNL; Rusanu, Aurelian [ORNL; Eisenbach, Markus [ORNL

2011-01-01T23:59:59.000Z

165

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

166

Adaptive Breast Radiation Therapy Using Modeling of Tissue Mechanics: A Breast Tissue Segmentation Study  

Science Conference Proceedings (OSTI)

Purpose: To validate and compare the accuracy of breast tissue segmentation methods applied to computed tomography (CT) scans used for radiation therapy planning and to study the effect of tissue distribution on the segmentation accuracy for the purpose of developing models for use in adaptive breast radiation therapy. Methods and Materials: Twenty-four patients receiving postlumpectomy radiation therapy for breast cancer underwent CT imaging in prone and supine positions. The whole-breast clinical target volume was outlined. Clinical target volumes were segmented into fibroglandular and fatty tissue using the following algorithms: physical density thresholding; interactive thresholding; fuzzy c-means with 3 classes (FCM3) and 4 classes (FCM4); and k-means. The segmentation algorithms were evaluated in 2 stages: first, an approach based on the assumption that the breast composition should be the same in both prone and supine position; and second, comparison of segmentation with tissue outlines from 3 experts using the Dice similarity coefficient (DSC). Breast datasets were grouped into nonsparse and sparse fibroglandular tissue distributions according to expert assessment and used to assess the accuracy of the segmentation methods and the agreement between experts. Results: Prone and supine breast composition analysis showed differences between the methods. Validation against expert outlines found significant differences (P<.001) between FCM3 and FCM4. Fuzzy c-means with 3 classes generated segmentation results (mean DSC = 0.70) closest to the experts' outlines. There was good agreement (mean DSC = 0.85) among experts for breast tissue outlining. Segmentation accuracy and expert agreement was significantly higher (P<.005) in the nonsparse group than in the sparse group. Conclusions: The FCM3 gave the most accurate segmentation of breast tissues on CT data and could therefore be used in adaptive radiation therapy-based on tissue modeling. Breast tissue segmentation methods should be used with caution in patients with sparse fibroglandular tissue distribution.

Juneja, Prabhjot, E-mail: Prabhjot.Juneja@icr.ac.uk [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom); Harris, Emma J. [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom); Kirby, Anna M. [Department of Academic Radiotherapy, Royal Marsden National Health Service Foundation Trust, Sutton (United Kingdom)] [Department of Academic Radiotherapy, Royal Marsden National Health Service Foundation Trust, Sutton (United Kingdom); Evans, Philip M. [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)

2012-11-01T23:59:59.000Z

167

A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer  

Science Conference Proceedings (OSTI)

Purpose: Although complementary and alternative medicine (CAM) utilization in breast cancer patients is reported to be high, there are few data on CAM practices in breast patients specifically during radiation. This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation. Materials/Methods: A validated CAM instrument with a self-skin assessment was administered to 360 Stage 0-III breast cancer patients from 5 centers during the last week of radiation. All data were analyzed to detect significant differences between users/nonusers. Results: CAM usage was reported in 54% of the study cohort (n=194/360). Of CAM users, 71% reported activity-based CAM (eg, Reiki, meditation), 26% topical CAM, and 45% oral CAM. Only 16% received advice/counseling from naturopathic/homeopathic/medical professionals before initiating CAM. CAM use significantly correlated with higher education level (P<.001), inversely correlated with concomitant hormone/radiation therapy use (P=.010), with a trend toward greater use in younger patients (P=.066). On multivariate analysis, level of education (OR: 6.821, 95% CI: 2.307-20.168, P<.001) and hormones/radiation therapy (OR: 0.573, 95% CI: 0.347-0.949, P=.031) independently predicted for CAM use. Significantly lower skin toxicity scores were reported in CAM users vs nonusers, respectively (mild: 34% vs 25%, severe: 17% vs 29%, P=.017). Conclusion: This is the first prospective study to assess CAM practices in breast patients during radiation, with definition of these practices as the first step for future investigation of CAM/radiation interactions. These results should alert radiation oncologists that a large percentage of breast cancer patients use CAM during radiation without disclosure or consideration for potential interactions, and should encourage increased awareness, communication, and documentation of CAM practices in patients undergoing radiation treatment for breast cancer.

Moran, Meena S., E-mail: meena.moran@yale.edu [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Ma Shuangge [Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut (United States)] [Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut (United States); Jagsi, Reshma [University of Michigan, Department of Radiation Oncology, Ann Arbor, MI (United States)] [University of Michigan, Department of Radiation Oncology, Ann Arbor, MI (United States); Yang, Tzu-I Jonathan [Yale University School of Medicine, New Haven, Connecticut (United States)] [Yale University School of Medicine, New Haven, Connecticut (United States); Higgins, Susan A. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Shoreline Medical Center, Guilford, Connecticut (United States); Weidhaas, Joanne B. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Wilson, Lynn D. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Lloyd, Shane [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Peschel, Richard [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States) [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut (United States); Gaudreau, Bryant [Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States)] [Department of Radiation Therapy, William W. Backus Hospital, Norwich, Connecticut (United States); Rockwell, Sara [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)] [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)

2013-01-01T23:59:59.000Z

168

Low dose radiation hypersensitivity and clustered DNA damages in human fibroblasts exposed to low dose and dose rate protons or 137CS y-rays  

SciTech Connect

Effective radioprotection for human space travelers hinges upon understanding the individual properties of charged particles. A significant fraction of particle radiation astronauts will encounter in space exploratory missions will come from high energy protons in galactic cosmic radiation (GCR) and/or possible exposures to lower energy proton flux from solar particle events (SPEs). These potential exposures present major concerns for NASA and others, in planning and executing long term space exploratory missions. We recently reported cell survival and transformation (acquisition of anchorage-independent growth in soft agar) frequencies in apparently normal NFF-28 primary human fibroblasts exposed to 0-30 cGy of 50MeV, 100MeV (SPE-like), or 1000 MeV (GCR-like) monoenergetic protons. These were modeled after 1989 SPE energies at an SPE-like low dose-rate (LDR) of 1.65 cGy/min or high dose rate (HDR) of 33.3 cGy/min delivered at the NASA Space Radiation Laboratory (NSRL) at BNL.

Bennett P. V.; Bennett, P.V.; Keszenman, D.J.; Johnson, A.M.; Sutherland, B.M.; Wilson, P.F.

2013-05-14T23:59:59.000Z

169

Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)  

Science Conference Proceedings (OSTI)

Purpose: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi-institutional study. Materials and Methods: Between September 2004 and July 2007, 59 eligible patients were analyzed. The median age was 73 years (range, 37-84 years). The International Federation of Gynecologic Oncology and Obstetrics stages were Ib1 in 35, IIa in 12, and IIb in 12 patients. Patients were treated with the constant method, which consisted of whole-pelvic external-beam radiation therapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions without chemotherapy. After radiation therapy the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. The CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as signal intensity changes in the bones, both on T1- and T2-weighted images. Results: The median follow-up was 24 months. The 2-year pelvic IF cumulative occurrence rate was 36.9% (21 patients). Using Common Terminology Criteria for Adverse Events version 3.0, grade 1, 2, and 3 IF were seen in 12 (21%), 6 (10%), and 3 patients (5%), respectively. Sixteen patients had multiple fractures, so IF were identified at 44 sites. The pelvic IF were frequently seen at the sacroileal joints (32 sites, 72%). Nine patients complained of pain. All patients' pains were palliated by rest or non-narcotic analgesic drugs. Higher age (>70 years) and low body weight (<50 kg) were thought to be risk factors for pelvic IF (P=.007 and P=.013, Cox hazard test). Conclusions: Cervical cancer patients with higher age and low body weight may be at some risk for the development of pelvic IF after pelvic radiation therapy.

Tokumaru, Sunao, E-mail: tokumaru@cc.saga-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Saga University, Saga (Japan)] [Department of Heavy Particle Therapy and Radiation Oncology, Saga University, Saga (Japan); Toita, Takafumi [Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa (Japan)] [Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa (Japan); Oguchi, Masahiko [Radiation Oncology Department, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo (Japan)] [Radiation Oncology Department, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo (Japan); Ohno, Tatsuya [Gunma University Heavy Ion Medical Center, Maebashi (Japan)] [Gunma University Heavy Ion Medical Center, Maebashi (Japan); Kato, Shingo [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan)] [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Niibe, Yuzuru [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan)] [Department of Radiology, School of Medicine, Kitasato University, Sagamihara (Japan); Kazumoto, Tomoko [Department of Radiology, Saitama Cancer Center, Saitama (Japan)] [Department of Radiology, Saitama Cancer Center, Saitama (Japan); Kodaira, Takeshi [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan)] [Department of Radiation Oncology, Aichi Cancer Center, Nagoya (Japan); Kataoka, Masaaki [Department of Radiology, National Shikoku Cancer Center, Matsuyama (Japan)] [Department of Radiology, National Shikoku Cancer Center, Matsuyama (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan)] [Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama (Japan); Kenjo, Masahiro [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan)] [Department of Radiation Oncology, Graduate School of Medical Science, Hiroshima University, Hiroshima (Japan); Yamauchi, Chikako [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan)] [Department of Radiation Oncology, Shiga Medical Center for Adults, Moriyama (Japan); Suzuki, Osamu [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan)] [Department of Radiation Oncology, Osaka Medical Center for Cancer, Osaka (Japan); Sakurai, Hideyuki [Proton Medical Research Center and Tsukuba University, Tuskuba (Japan)] [Proton Medical Research Center and Tsukuba University, Tuskuba (Japan); Teshima, Teruki [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita (Japan)] [Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Suita (Japan); Kagami, Yoshikazu [Department of Radiology, Showa University School of Medicine, Tokyo (Japan)] [Department of Radiology, Showa University School of Medicine, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan)] [Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan)] [Department of Radiation Oncology and Image-applied Therapy, Kyoto University, Graduate School of Medicine, Kyoto (Japan); and others

2012-10-01T23:59:59.000Z

170

Essays using military-induced variation to study social interactions, human capital development, and labor markets  

E-Print Network (OSTI)

This dissertation consists of four empirical studies, each using military-induced variation to examine various aspects of human capital production and the U.S. labor market. The first two chapters study the effects of ...

Lyle, David S. (David Stephen), 1971-

2003-01-01T23:59:59.000Z

171

Low Dose Radiation Research Program: Real-time Study of Signal Transduction  

NLE Websites -- All DOE Office Websites (Extended Search)

Real-time Study of Signal Transduction Pathways Involving in Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging Authors: Prakash D. Nallathamby, X. Nancy Xu, Mohan Natarajan Institutions: Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia and Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, Texas The mechanisms of bystander effects remain largely unknown. Bystander responses are thought to depend on activation of cellular communication processes. Recent studies have speculated that several crucial signal transduction pathways could play a major role in bystander effects. These crucial signal transduction pathways are controlled by a coordinated

172

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary glandas a means of understanding human risk for breast cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

susceptibility to low-dose ionizing radiation in the mouse mammary gland susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders 1 , Francesco Marchetti 1 , Ju Han 1 , Sandhya Bhatnagar 1 , Nadire Duru 1 , Zhi Hu 1 , Jian-Hua Mao 1 , Mina Bissell 1 , Joe Gray 1,2 , Gary H. Karpen 1 , Priscilla K. Cooper 1 and Andrew J. Wyrobek 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 Current affiliation: Biomedical Engineering, Oregon Health Science Univ, Portland, OR Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer.

173

"Radiative Closure Studies for Clear Skies During the ARM 2003 Aerosol Intensive Observation Period"  

SciTech Connect

The Department of Energy's Atmospheric Radiation Measurement (ARM) program sponsored a large intensive observation period (IOP) to study aerosol during the month of May 2003 around the Southern Great Plains (SGP) Climate Research Facility (CRF) in north central Oklahoma. Redundant measurements of aerosol optical properties were made using different techniques at the surface as well as in vertical profile with sensors aboard two aircraft. One of the principal motivations for this experiment was to resolve the disagreement between models and measurements of diffuse horizontal broadband shortwave irradiance at the surface, especially for modest aerosol loading. This paper focuses on using the redundant aerosol and radiation measurements during this IOP to compare direct beam and diffuse horizontal broadband shortwave irradiance measurements and models at the surface for a wide range of aerosol cases that occurred during 30 clear-sky periods on 13 days of May 2003. Models and measurements are compared over a large range of solar-zenith angles. Six different models are used to assess the relative agreement among them and the measurements. Better agreement than previously achieved appears to be the result of better specification of input parameters and better measurements of irradiances than in prior studies. Biases between modeled and measured direct irradiances are less than 1%, and biases between modeled and measured diffuse irradiances are less than 2%.

J. J. Michalsky, G. P. Anderson, J. Barnard, J. Delamere, C. Gueymard, S. Kato, P. Kiedron, A. McComiskey, and P. Ricchiazzi

2006-04-01T23:59:59.000Z

174

IR Radiation from Trees to a Ski Run: A Case Study  

Science Conference Proceedings (OSTI)

Accurately calculating the surface radiation budget of a groomed ski run is crucial when determining snow surface temperature and other snow-related variables, knowledge of which is important for ski racing. Downwelling longwave radiation can ...

Rosie Howard; Roland Stull

2013-07-01T23:59:59.000Z

175

Observational and Theoretical Studies of Solar Radiation in Arctic Stratus Clouds  

Science Conference Proceedings (OSTI)

A series of clouds-radiation experiments was carried out in June 1980 in Arctic stratus clouds occurring over the Beaufort Sea using the NCAR Electra aircraft. This paper is an analysis of the hemispheric radiation fields obtained with Eppley ...

G. F. Herman; J. A. Curry

1984-01-01T23:59:59.000Z

176

A Study of the Incoming Longwave Atmospheric Radiation from a Clear Sky  

Science Conference Proceedings (OSTI)

A band model for atmospheric absorption is used to calculate the incoming longwave atmospheric radiative flux for some typical clear sky conditions. The sky radiation is also measured using a specially-designed calorimetric apparatus over a wide ...

J. W. Ramsey; H. D. Chiang; R. J. Goldstein

1982-04-01T23:59:59.000Z

177

Spreader-Bar Radiation Detection System Enhancements: A Modeling and Simulation Study  

SciTech Connect

This report provides the modeling and simulation results of the investigation of enhanced spreader bar radiation detection systems.

Ely, James H.; Ashbaker, Eric D.; Batdorf, Michael T.; Baciak, James E.; Hensley, Walter K.; Jarman, Kenneth D.; Robinson, Sean M.; Sandness, Gerald A.; Schweppe, John E.

2012-11-13T23:59:59.000Z

178

World Wide Web Access to Radiation Datasets for Environmental and Climate Change Studies  

Science Conference Proceedings (OSTI)

Five years of scanner data from the Earth Radiation Budget Experiment (ERBE), eight years of surface radiation budget (SRB) data, and one year of scanner radiation budget data from the FrenchRussianGerman experiment, ScaRaB, will be available ...

T. Dale Bess; Ann B. Carlson; Calvin Mackey; Fredrick M. Denn; Anne Wilber; Nancy Ritchey

2000-11-01T23:59:59.000Z

179

Neutron Radiation Embrittlement and Microstructural Characterization of Ferritic Steels: Joint EPRI-CRIEPI RPV Embrittlement Studies  

Science Conference Proceedings (OSTI)

The identification of mechanisms by which neutron radiation embrittlement occurs in reactor pressure vessel (RPV) ferritic material may permit the design of alloys in which the radiation-induced degradation in mechanical properties is minimized or eliminated. This report documents the microstructural characterization of several RPV steels that will be used to develop predictive models for radiation embrittlement.

1995-01-21T23:59:59.000Z

180

Ultrafast time dynamics studies of periodic lattices with free electron laser radiation  

Science Conference Proceedings (OSTI)

It has been proposed that radiation from free electron laser (FEL) at Hamburg (FLASH) can be used for ultrafast time-resolved x-ray diffraction experiments based on the near-infrared (NIR) pump/FEL probe scheme. Here, investigation probing the ultrafast structural dynamics of periodic nano-crystalline organic matter (silver behenate) with such a scheme is reported. Excitation with a femtosecond NIR laser leads to an ultrafast lattice modification which time evolution has been studied through the scattering of vacuum ultraviolet FEL pulses. The found effect last for 6 ps and underpins the possibility for studying nanoperiodic dynamics down to the FEL source time resolution. Furthermore, the possibility of extending the use of silver behenate (AgBh) as a wavelength and temporal calibration tool for experiments with soft x-ray/FEL sources is suggested.

Quevedo, W.; Busse, G.; Hallmann, J.; More, R.; Petri, M.; Rajkovic, I. [Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen (Germany); Krasniqi, F.; Rudenko, A. [Max Planck Advanced Study Group at CFEL, Notkestrasse 85, 22607 Hamburg (Germany); Tschentscher, T. [European XFEL GmbH, Albert-Einstein-Ring 19, 22671 Hamburg (Germany); Stojanovic, N.; Duesterer, S.; Treusch, R.; Tolkiehn, M. [HASYLAB at DESY, Notkestrasse 85, 22607 Hamburg (Germany); Techert, S. [Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen (Germany); Max Planck Advanced Study Group at CFEL, Notkestrasse 85, 22607 Hamburg (Germany)

2012-11-01T23:59:59.000Z

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181

Overview of the 2010 Carbonaceous Aerosols and Radiative Effects Study (CARES)  

Science Conference Proceedings (OSTI)

Substantial uncertainties still exist in the scientific understanding of the possible interactions between urban and natural (biogenic) emissions in the production and transformation of atmospheric aerosol and the resulting impact on climate change. The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) program's Carbonaceous Aerosol and Radiative Effects Study (CARES) carried out in June 2010 in Central Valley, California, was a comprehensive effort designed to improve this understanding. The primary objective of the field study was to investigate the evolution of secondary organic and black carbon aerosols and their climate-related properties in the Sacramento urban plume as it was routinely transported into the forested Sierra Nevada foothills area. Urban aerosols and trace gases experienced significant physical and chemical transformations as they mixed with the reactive biogenic hydrocarbons emitted from the forest. Two heavily-instrumented ground sites - one within the Sacramento urban area and another about 40 km to the northeast in the foothills area - were set up to characterize the evolution of meteorological variables, trace gases, aerosol precursors, aerosol size, composition, and climate-related properties in freshly polluted and 'aged' urban air. On selected days, the DOE G-1 aircraft was deployed to make similar measurements upwind and across the evolving Sacramento plume in the morning and again in the afternoon. The NASA B-200 aircraft, carrying remote sensing instruments, was also deployed to characterize the vertical and horizontal distribution of aerosols and aerosol optical properties within and around the plume. This overview provides: a) the scientific background and motivation for the study, b) the operational and logistical information pertinent to the execution of the study, c) an overview of key observations and initial results from the aircraft and ground-based sampling platforms, and d) a roadmap of planned data analyses and focused modeling efforts that will facilitate the integration of new knowledge into improved representations of key aerosol processes in climate models.

Zaveri, Rahul A.; Shaw, William J.; Cziczo, D. J.; Schmid, Beat; Ferrare, R.; Alexander, M. L.; Alexandrov, Mikhail; Alvarez, R. J.; Arnott, W. P.; Atkinson, D.; Baidar, Sunil; Banta, Robert M.; Barnard, James C.; Beranek, Josef; Berg, Larry K.; Brechtel, Fred J.; Brewer, W. A.; Cahill, John F.; Cairns, Brian; Cappa, Christopher D.; Chand, Duli; China, Swarup; Comstock, Jennifer M.; Dubey, Manvendra K.; Easter, Richard C.; Erickson, Matthew H.; Fast, Jerome D.; Floerchinger, Cody; Flowers, B. A.; Fortner, Edward; Gaffney, Jeffrey S.; Gilles, Mary K.; Gorkowski, K.; Gustafson, William I.; Gyawali, Madhu S.; Hair, John; Hardesty, Michael; Harworth, J. W.; Herndon, Scott C.; Hiranuma, Naruki; Hostetler, Chris A.; Hubbe, John M.; Jayne, J. T.; Jeong, H.; Jobson, Bertram T.; Kassianov, Evgueni I.; Kleinman, L. I.; Kluzek, Celine D.; Knighton, B.; Kolesar, K. R.; Kuang, Chongai; Kubatova, A.; Langford, A. O.; Laskin, Alexander; Laulainen, Nels S.; Marchbanks, R. D.; Mazzoleni, Claudio; Mei, F.; Moffet, Ryan C.; Nelson, Danny A.; Obland, Michael; Oetjen, Hilke; Onasch, Timothy B.; Ortega, Ivan; Ottaviani, M.; Pekour, Mikhail S.; Prather, Kimberly A.; Radney, J. G.; Rogers, Ray; Sandberg, S. P.; Sedlacek, Art; Senff, Christoph; Senum, Gunar; Setyan, Ari; Shilling, John E.; Shrivastava, ManishKumar B.; Song, Chen; Springston, S. R.; Subramanian, R.; Suski, Kaitlyn; Tomlinson, Jason M.; Volkamer, Rainer M.; Wallace, Hoyt A.; Wang, J.; Weickmann, A. M.; Worsnop, Douglas R.; Yu, Xiao-Ying; Zelenyuk, Alla; Zhang, Qi

2012-08-22T23:59:59.000Z

182

Introduction and Fundamentals: Course on Advances in Radiation  

E-Print Network (OSTI)

exposure to Ionizing Radiation - is it really necessary?"Sternglass, "Environmental Radiation and Human Health," op.on the Effects of Atomic Radiation Sources and Effects of

Thomas, Ralph H.

2010-01-01T23:59:59.000Z

183

Human radiation studies: Remembering the early years. Oral history of John W. Healy, November 28, 1994  

SciTech Connect

This document provides a transcript of an interview with John W. Healy concerning his recollections of measuring radioactive effluents at Hanford. Included are comments concerning the `Green Run`, other radioiodine releases, and a release of radioruthenium.

1995-05-01T23:59:59.000Z

184

Cell Type-dependent Gene Transcription Profile in Three Dimensional Human Skin Tissue Model Exposed to Low Doses of Ionizing Radiation: Implications for Medical Exposures  

SciTech Connect

The concern over possible health risks from exposures to low doses of ionizing radiation has been driven largely by the increase in medical exposures, the routine implementation of X-ray backscatter devices for airport security screening, and, most recently, the nuclear incident in Japan. Due to a paucity of direct epidemiological data at very low doses, cancer risk must be estimated from high dose exposure scenarios. However, there is increasing evidence that low and high dose exposures result in different signaling events and may have different mechanisms of cancer induction. We have examined the radiation induced temporal response of an in vitro three dimensional (3D) human skin tissue model using microarray-based transcriptional profiling. Our data shows that exposure to 100 mGy of X-rays is sufficient to affect gene transcription. Cell type specific analysis showed significant changes in gene expression with the levels of > 1400 genes altered in the dermis and > 400 genes regulated in the epidermis. The two cell types rarely exhibited overlapping responses at the mRNA level. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) measurements validated the microarray data in both regulation direction and value. Key pathways identified relate to cell cycle regulation, immune responses, hypoxia, reactive oxygen signaling, and DNA damage repair. We discuss in particular the role of proliferation and emphasizing how the disregulation of cellular signaling in normal tissue may impact progression towards radiation induced secondary diseases.

Freiin von Neubeck, Claere H.; Shankaran, Harish; Karin, Norman J.; Kauer, Paula M.; Chrisler, William B.; Wang, Xihai; Robinson, Robert J.; Waters, Katrina M.; Tilton, Susan C.; Sowa, Marianne B.

2012-04-17T23:59:59.000Z

185

Workshop Report on Atomic Bomb Dosimetry--Residual Radiation Exposure: Recent Research and Suggestions for Future Studies  

SciTech Connect

There is a need for accurate dosimetry for studies of health effects in the Japanese atomic bomb survivors because of the important role that these studies play in worldwide radiation protection standards. International experts have developed dosimetry systems, such as the Dosimetry System 2002 (DS02), which assess the initial radiation exposure to gamma rays and neutrons but only briefly consider the possibility of some minimal contribution to the total body dose by residual radiation exposure. In recognition of the need for an up-to-date review of the topic of residual radiation exposure in Hiroshima and Nagasaki, recently reported studies were reviewed at a technical session at the 57th Annual Meeting of the Health Physics Society in Sacramento, California, 22-26 July 2012. A one-day workshop was also held to provide time for detailed discussion of these newer studies and to evaluate their potential use in clarifying the residual radiation exposures to the atomic-bomb survivors at Hiroshima and Nagasaki. Suggestions for possible future studies are also included in this workshop report.

none,

2013-06-06T23:59:59.000Z

186

Study of the secondary neutral radiation in proton therapy: Toward an indirect in vivo dosimetry  

Science Conference Proceedings (OSTI)

Purpose: Secondary particles produced in the collision of protons with beam modifiers are of concern in proton therapy. Nevertheless, secondary radiation can provide information on the dosimetric parameters through its dependency on the modulating accessories (range shifter and range modulating wheel). Relatively little data have been reported in the literature for low-energy proton beams. The present study aims at characterizing the neutron and photon secondary radiation at the low-energy proton therapy facility of the Centre Antoine Lacassagne (CAL), and studying their correlation to the dosimetric parameters to explore possible practical uses of secondary radiation in the treatment quality for proton therapy. Methods: The Monte Carlo code MCNPX was used to simulate the proton therapy facility at CAL. Neutron and photon fluence, {Phi}, and ambient dose equivalent per proton dose, H*(10)/D, were determined across the horizontal main plane spanning the whole treatment room. H*(10)/D was also calculated at two positions of the treatment room where dosimetric measurements were performed for validation of the Monte Carlo calculations. Calculations and measurements were extended to 100 clinical spread-out Bragg Peaks (SOBPs) covering the whole range of therapeutic dose rates (D/MU) employed at CAL. In addition, the values of D and MU were also calculated for each SOBP and the results analyzed to study the relationship between secondary radiation and dosimetric parameters. Results: The largest production of the secondary particles takes place at the modulating devices and the brass collimators located along the optical bench. Along the beam line and off the beam axis to 2.5 m away, H*(10)/D values ranged from 5.4 {mu}Sv/Gy to 5.3 mSv/Gy for neutrons, and were 1 order of magnitude lower for photons. H*(10)/D varied greatly with the distance and angle to the beam axis. A variation of a factor of 5 was found for the different range of modulations (SOBPs). The ratios between calculations and measurements were 2.3 and 0.5 for neutrons and photons, respectively, and remained constant for all the range of SOBPs studied, which provided validation for the Monte Carlo calculations. H*(10)/D values were found to correlate to the proton dose rate D/MU with a power fit, both for neutrons and photons. This result was exploited to implement a system to obtain D/MU values from the measurement of the integrated photon ambient dose equivalent H*(10) during treatment, which provides a method to control the dosimetric parameters D/MU and D. Conclusions: The treatment room at CAL is moderately polluted by secondary particles. The constant ratio between measurements and calculations for all SOBPs showed that simulations correctly predict the dosimetric parameters and the dependence of the production of secondary particles on the modulation. The correlation between H*(10)/D and D/MU is a useful tool for quality control and is currently used at CAL. This system works as an indirect in vivo dosimetry method, which is so far not feasible in proton therapy. This tool requires very simple instrumentation and can be implemented from the measurement of either photons or neutrons.

Carnicer, A.; Letellier, V.; Rucka, G.; Angellier, G.; Sauerwein, W.; Herault, J. [Centre Antoine Lacassagne, Cyclotron Biomedical, 227 Avenue de la Lanterne, 06200 Nice (France); Institut Curie, Centre de Protontherapie, Campus Universitaire d'Orsay, Batiment 101, 91898 Orsay Cedex (France); Hopital de la Croix Rouge, Centre de radiotherapie St Louis, Rue Andre Blondel, 83100 Toulon (France); Centre Antoine Lacassagne, Cyclotron Biomedical, 227 Avenue de la Lanterne, 06200 Nice (France); Universitaet Duisburg-Essen, Universitaetsklinikum Essen, Strahlenklinik, 45122 Essen (Germany); Centre Antoine Lacassagne, Cyclotron Biomedical, 227 Avenue de la Lanterne, 06200 Nice (France)

2012-12-15T23:59:59.000Z

187

Thermal reactions of disilane on Si(100) studied by synchrotron-radiation photoemission  

SciTech Connect

H-terminated Si(100) surfaces were formed by saturation exposure of Si(100) to disilane at room temperature. Annealing these surfaces to progressively higher temperatures resulted in hydrogen desorption. This process, of basic importance to the growth of Si by atomic layer epitaxy using disilane, was studied by synchrotron-radiation photoemission. The Si 2[ital p] core-level line shape, the position of the Fermi level within the band gap, the work function, and the ionization potential were measured as a function of annealing temperature. These results revealed two steps in the thermal reaction preceding the recovery of the clean surface. The dihydride radicals on the surface are converted to monohydride radicals at 500--610 K, and the monohydride radicals decompose at 700--800 K.

Lin, D.; Miller, T.; Chiang, T. (Department of Physics and Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, Illinois 61801-3080 (United States)); Tsu, R.; Greene, J.E. (Department of Materials Science and Engineering, Coordinated Science Laboratory, and Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801-3080 (United States))

1993-10-15T23:59:59.000Z

188

Understanding human-smartphone concerns: a study of battery life  

Science Conference Proceedings (OSTI)

This paper presents a large, 4-week study of more than 4000 people to assess their smartphone charging habits to identify timeslots suitable for opportunistic data uploading and power intensive operations on such devices, as well as opportunities to ... Keywords: android, autonomous logging, battery life, large-scale study, smartphones

Denzil Ferreira; Anind K. Dey; Vassilis Kostakos

2011-06-01T23:59:59.000Z

189

Understanding human mobility patterns through mobile phone records : a cross-cultural study  

E-Print Network (OSTI)

In this thesis, I present a cross-cultural study on human's trip length distribution and how it might be influenced by regional socio-economic factors, such as population density, income and unemployment rate. Mobile phone ...

Ji, Yan, S.M. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

190

What can be learned from epidemiologic studies of persons exposed to low doses of radiation?  

SciTech Connect

The main objective of radiation risk assessment is to determine the risk of various adverse health effects associated with exposure to low doses and low dose rates. Extrapolation of risks from studies of persons exposed at high doses (generally exceeding 1 Sv) and dose rates has been the primary approach used to achieve this objective. The study of Japanese atomic bomb survivors in Hiroshima and Nagasaki has played an especially important role in risk assessment efforts. A direct assessment of the dose-response function based on studies of persons exposed at low doses and dose rates is obviously desirable. This paper focuses on the potential of both current and future nuclear workers studies for investigating the dose-response functions at low doses, and also discusses analyses making use of the low dose portion of the atomic bomb survivor data. Difficulties in using these data are the statistical imprecision of estimated dose-response parameters, and potential bias resulting from confounding factors and from uncertainties in dose estimates.

Gilbert, E.S.

1993-04-01T23:59:59.000Z

191

Real Time and In Situ Studies of Materials in a Radiation Environment  

Science Conference Proceedings (OSTI)

... as the design of radiation resistant materials, synthesis mechanisms for Actinides and Technetium compounds, and phase diagrams for metallic nuclear fuels.

192

Radiation Safety Manual Dec 2012 Page 1 RADIATION SAFETY  

E-Print Network (OSTI)

. Management Commitment B. Training C. Monitoring of Individual Radiation Exposures D. Program Reviews 1 of Radiation A. Research Applications 1. Non-Human User 2. Animal Use 3. Human Use B. Clinical Applications C Materials Chapter VI: Occupational Exposure to Radiation and Personnel Monitoring and Bioassay Program #12;A

Grishok, Alla

193

Radiation Leukaemongenesis at Low Doses  

NLE Websites -- All DOE Office Websites (Extended Search)

Leukaemongenesis at Low Doses Leukaemongenesis at Low Doses Simon Bouffler Health Protection Agency Abstract Myeloid leukaemias feature prominently among the cancers associated with human exposures to ionising radiation. The CBA mouse model of radiation-induced acute myeloid leukaemia (AML) has been used extensively for both quantitative and mechanistic studies. Loss of genetic material from chromosome 2 (chr2) is known to be associated with most radiation-induced AMLs. AML develops in CBA mice exposed to X- or γ-radiation, after a mean latency period of 18 months, with a maximal incidence of approximately 25% at 3Gy. A strong candidate AML-suppressor gene located within the commonly deleted region of chr2 has been identified, Sƒpil/PU.1. This gene suffers hemizygous loss and specific

194

Study on development of education model and its evaluation system for radiation safety  

E-Print Network (OSTI)

As one of the detailed action strategy of multi object preparedness for strengthening of radiation safety management by MOST, this project was performed, in order to promote the safety culture for user and radiation worker through effective education program. For the prevention of radiological accident and effective implementation of radiation safety education and training, this project has been carried out the development of education model and its evaluation system on radiation safety. In the development of new education model, education course was classified; new and old radiation worker, temporary worker, lecturer and manager. The education model includes the contents of expanding the education opportunity and workplace training. In the development of evaluation system, the recognition criteria for commission-education institute and inside-education institute which should establish by law were suggested for evaluation program. The recognition criteria contains classification, student, method, facilities, ...

Seo, K W; Nam, Y M

2002-01-01T23:59:59.000Z

195

Pilot Study Of Impedance-controlled Microcurrent Therapy For Managing Radiation-induced Fibrosis In Head-and-neck Cancer Patients  

E-Print Network (OSTI)

Pilot Study Of Impedance-controlled Microcurrent Therapy For Managing Radiation-induced Fibrosis In Head-and-neck Cancer Patients

Lennox, A J

2002-01-01T23:59:59.000Z

196

Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study  

Science Conference Proceedings (OSTI)

Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

Brooks, Jennifer D., E-mail: brooksj@mskcc.org [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Boice, John D. [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States)] [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Reiner, Anne S. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bernstein, Leslie [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States)] [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States); John, Esther M. [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States)] [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, IA (United States)] [Department of Epidemiology, University of Iowa, Iowa City, IA (United States); Mellemkjaer, Lene [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark)] [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark); Knight, Julia A. [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada)] [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada); Thomas, Duncan C.; Haile, Robert W. [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Capanu, Marinela; Bernstein, Jonine L. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shore, Roy E. [Department of Environmental Medicine, New York University, New York, NY (United States) [Department of Environmental Medicine, New York University, New York, NY (United States); Radiation Effects Research Foundation, Hiroshima (Japan)

2012-11-15T23:59:59.000Z

197

Potential of Hybrid Computational Phantoms for Retrospective Heart Dosimetry After Breast Radiation Therapy: A Feasibility Study  

SciTech Connect

Purpose: Current retrospective cardiovascular dosimetry studies are based on a representative patient or simple mathematic phantoms. Here, a process of patient modeling was developed to personalize the anatomy of the thorax and to include a heart model with coronary arteries. Methods and Materials: The patient models were hybrid computational phantoms (HCPs) with an inserted detailed heart model. A computed tomography (CT) acquisition (pseudo-CT) was derived from HCP and imported into a treatment planning system where treatment conditions were reproduced. Six current patients were selected: 3 were modeled from their CT images (A patients) and the others were modelled from 2 orthogonal radiographs (B patients). The method performance and limitation were investigated by quantitative comparison between the initial CT and the pseudo-CT, namely, the morphology and the dose calculation were compared. For the B patients, a comparison with 2 kinds of representative patients was also conducted. Finally, dose assessment was focused on the whole coronary artery tree and the left anterior descending coronary. Results: When 3-dimensional anatomic information was available, the dose calculations performed on the initial CT and the pseudo-CT were in good agreement. For the B patients, comparison of doses derived from HCP and representative patients showed that the HCP doses were either better or equivalent. In the left breast radiation therapy context and for the studied cases, coronary mean doses were at least 5-fold higher than heart mean doses. Conclusions: For retrospective dose studies, it is suggested that HCP offers a better surrogate, in terms of dose accuracy, than representative patients. The use of a detailed heart model eliminates the problem of identifying the coronaries on the patient's CT.

Moignier, Alexandra, E-mail: alexandra.moignier@irsn.fr [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Derreumaux, Sylvie; Broggio, David; Beurrier, Julien [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Chea, Michel; Boisserie, Gilbert [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)] [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France); Franck, Didier; Aubert, Bernard [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France)] [Institut de Radioprotection et de Surete Nucleaire, Fontenay-aux-Roses (France); Mazeron, Jean-Jacques [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)] [Groupe Hospitalier Pitie Salpetriere, Service de Radiotherapie, Paris (France)

2013-02-01T23:59:59.000Z

198

Measuring Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Measurement Activity SI Units and Prefixes Conversions Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration...

199

DOE Order Self Study Modules - 10 CFR 835 Occupational Radiation Protection  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

10 CFR 835 10 CFR 835 OCCUPATIONAL RADIATION PROTECTION NATIONAL NUCLEAR SECURITY ADMINISTRATION LEARNING AND CAREER DEVELOPMENT DEPARTMENT Change No: 1 10 CFR 835 Level: Familiar Date:11/1/08 1 10/1/08 10 CFR 835 OCCUPATIONAL RADIATION PROTECTION FAMILIAR LEVEL ___________________________________________________________________________ OBJECTIVES Given the familiar level of this module and the resources, you will be able to perform the following: 1. State the scope of 10 CFR 835. 2. Define the following terms. annual limit on intake bioassay contamination area derived air concentration high contamination area radiation weighting factor 3. State the requirements of the general rule. 4. State the radiation protection program requirements. 5. State the requirements of the internal audit.

200

A Systematic Study of GCM Sensitivity to Latitudinal Changes in Solar Radiation  

Science Conference Proceedings (OSTI)

Paleoclimatic data and climate model simulations have demonstrated that orbitally forced changes in solar radiation can have a pronounced effect on global climate. Key questions remain, however, about the spatial patterns in the climatic ...

Benjamin Felzer; Robert J. Oglesby; Hong Shao; Thompson Webb III; Dena E. Hyman; Warren L. Prell; John E. Kutzbach

1995-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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201

On the Use of Earth Radiation Budget Statistics for Studies of Clouds and Climate  

Science Conference Proceedings (OSTI)

Daily observations of albedo and outgoing terrestrial radiation derived from NOAA Scanning Radiometer measurements are used to relate cloudiness variations to regional features of the general circulation and to estimate the relative importance of ...

Dennis L. Hartmann; David A. Short

1980-06-01T23:59:59.000Z

202

PHOTOEMISSION STUDIES OF CLEAN AND ADSORBATE COVERED METAL SURFACES USING SYNCHROTRON AND UV RADIATION SOURCES  

E-Print Network (OSTI)

c J/ l TABLE II, SSRL 4 Beam Line - Monochroraatorhave made on the A oratory (SSRL). beam line at the Stanfordas they pertain to the SSRL (Stanford Synchrotron Radiation

Apai II, jG.R.

2011-01-01T23:59:59.000Z

203

A Cross-Cultural Study on the Perception of Sociability within Human-Computer Interaction  

Science Conference Proceedings (OSTI)

This study tries to use speech and dynamic emoticons as social cues to create a more sociable human-computer interaction. A cross-cultural study was conducted to investigate the influence of cultural backgrounds (Taiwan and America) on children's perceptions ... Keywords: Children, Cultural difference, Dynamic Emoticon, Interaction design, Sociability, Speech

Fang-Wu Tung; Keiichi Sato; Yi-Shin Deng; Tsai-Yi Lin

2009-07-01T23:59:59.000Z

204

A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas  

SciTech Connect

Purpose: Despite recent advances in the management of high-grade and recurrent gliomas, survival remains poor. Antiangiogenic therapy has been shown to be efficacious in the treatment of high-grade gliomas both in preclinical models and in clinical trials. We sought to determine the safety and maximum tolerated dose of sorafenib when combined with both radiation and temozolomide in the primary setting or radiation alone in the recurrent setting. Methods and Materials: This was a preclinical study and an open-label phase I dose escalation trial. Multiple glioma cell lines were analyzed for viability after treatment with radiation, temozolomide, or sorafenib or combinations of them. For patients with primary disease, sorafenib was given concurrently with temozolomide (75 mg/m{sup 2}) and 60 Gy radiation, for 30 days after completion of radiation. For patients with recurrent disease, sorafenib was combined with a hypofractionated course of radiation (35 Gy in 10 fractions). Results: Cell viability was significantly reduced with the combination of radiation, temozolomide, and sorafenib or radiation and sorafenib. Eighteen patients (11 in the primary cohort, 7 in the recurrent cohort) were enrolled onto this trial approved by the institutional review board. All patients completed the planned course of radiation therapy. The most common toxicities were hematologic, fatigue, and rash. There were 18 grade 3 or higher toxicities. The median overall survival was 18 months for the entire population. Conclusions: Sorafenib can be safely combined with radiation and temozolomide in patients with high-grade glioma and with radiation alone in patients with recurrent glioma. The recommended phase II dose of sorafenib is 200 mg twice daily when combined with temozolomide and radiation and 400 mg with radiation alone. To our knowledge, this is the first publication of concurrent sorafenib with radiation monotherapy or combined with radiation and temozolomide.

Den, Robert B., E-mail: robert.den@jeffersonhospital.org [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Kamrava, Mitchell [Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland (United States)] [Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland (United States); Sheng, Zhi [Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (United States)] [Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (United States); Werner-Wasik, Maria; Dougherty, Erin; Marinucchi, Michelle [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Lawrence, Yaacov R. [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States) [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Center for Translational Research in Radiation Oncology, Sheba Medical Center (Israel); Hegarty, Sarah; Hyslop, Terry [Department of Biostatistics, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)] [Department of Biostatistics, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Andrews, David W.; Glass, Jon [Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)] [Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Friedman, David P. [Department of Radiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)] [Department of Radiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Green, Michael R. [Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (United States)] [Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts (United States); Camphausen, Kevin [Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland (United States)] [Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland (United States); Dicker, Adam P. [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)] [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)

2013-02-01T23:59:59.000Z

205

Aerosol-Cloud-Radiation Interaction Studies with GEOS-4 Model and Comparison with Observations .  

E-Print Network (OSTI)

??Increasing human population and rapid urbanization in the last two decades have caused a sharp rise in anthropogenic aerosols particularly over South and East Asia. (more)

Bhattacharjee, Partha Sarathi

2011-01-01T23:59:59.000Z

206

Aerosol-Cloud-Radiation Interaction Studies with GEOS-4 model and Comparison with Observations.  

E-Print Network (OSTI)

?? Increasing human population and rapid urbanization in the last two decades have caused a sharp rise in anthropogenic aerosols particularly over South and East (more)

Bhattacharjee, Partha Sarathi

2011-01-01T23:59:59.000Z

207

Oral Histories: Radiation Biologist Marvin Goldman, Ph.D.  

NLE Websites -- All DOE Office Websites (Extended Search)

8 8 HUMAN RADIATION STUDIES: REMEMBERING THE EARLY YEARS Oral History of Radiation Biologist Marvin Goldman, Ph.D. Conducted December 22, 1994 United States Department of Energy Office of Human Radiation Experiments September 1995 CONTENTS Foreword Short Biography Educational Background and Early Involvement in Radiation Research Brookhaven Acquaintances and Early Hospital Research (Circa 1952) Vulnerable Populations and Acceptable Risks Research at the University of Rochester (1952-57) Relationship with Newell Stannard and Stafford Warren (1952-57) Participation in "Project Sunshine" and Move to the University of California, Davis (Mid '50s to '58) Participation in Beagle Studies at the University of California at Davis (1958 to '60s) Budget Concerns and Goldman's Other Radiation Research Projects (1965 to Late '60s)

208

DOE Order Self Study Modules - DOE G 441.1-1C Radiation Protection Programs Guide  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

41.1-1C 41.1-1C RADIATION PROTECTION PROGRAMS GUIDE NATIONAL NUCLEAR SECURITY ADMINISTRATION LEARNING AND CAREER DEVELOPMENT DEPARTMENT Change No: 1 DOE G 441.1-1C Level: Familiar Date: 12/1/08 1 DOE G 441.1-1C, RADIATION PROTECTION PROGRAMS GUIDE FAMILIAR LEVEL _________________________________________________________________________ OBJECTIVES Given the familiar level of this module and the resources listed below, you will be able to 1. Match radiation protection-related terms to their definitions; 2. Discuss the elements that should be taken into consideration to determine the likelihood of an individual receiving a dose in excess of a regulatory monitoring threshold; 3. Give three examples of criteria that should trigger a formal as-low-as-is-

209

Experimental study of variations in background radiation and the effect on Nuclear Car Wash sensitivity  

Science Conference Proceedings (OSTI)

Error rates in a cargo screening system such as the Nuclear Car Wash [1-7] depend on the standard deviation of the background radiation count rate. Because the Nuclear Car Wash is an active interrogation technique, the radiation signal for fissile material must be detected above a background count rate consisting of cosmic, ambient, and neutron-activated radiations. It was suggested previously [1,6] that the Corresponding negative repercussions for the sensitivity of the system were shown. Therefore, to assure the most accurate estimation of the variation, experiments have been performed to quantify components of the actual variance in the background count rate, including variations in generator power, irradiation time, and container contents. The background variance is determined by these experiments to be a factor of 2 smaller than values assumed in previous analyses, resulting in substantially improved projections of system performance for the Nuclear Car Wash.

Church, J; Slaughter, D; Norman, E; Asztalos, S; Biltoft, P

2007-02-07T23:59:59.000Z

210

29th International Cosmic Ray Conference Pune (2005) 1, 301-302 Human Exploration of the Moon and Mars: Space Radiation Data,  

E-Print Network (OSTI)

and development of instrumentation to guide NASA in managing the radiation exposure of the crew during the manned to carefully manage the radiation exposure of the crew in real time because of the variability of the radiation occurs. This is especially true if it occurs during a lunar excursion. A substantial radiation exposure

Lin, Zi-wei

211

AC field exposure study: human exposure to 60-Hz electric fields  

SciTech Connect

The objective of this study was to develop a method of estimating human exposure to the 60 Hz electric fields created by transmission lines. The Activity Systems Model simulates human activities in a variety of situations where exposure to electric fields is possible. The model combines maps of electric fields, activity maps, and experimentally determined activity factors to provide histograms of time spent in electric fields of various strengths in the course of agricultural, recreational, and domestic activities. For corroboration, the study team measured actual human exposure at locations across the United States near transmission lines ranging in voltage from 115 to 1200 kV. The data were collected with a specially designed vest that measures exposure. These data demonstrate the accuracy of the exposure model presented in this report and revealed that most exposure time is spent in fields of magnitudes similar to many household situations. The report provides annual exposure estimates for human activities near transmission lines and in the home and compares them with exposure data from typical laboratory animal experiments. For one exposure index, the cumulative product of time and electric field, exposure during some of the laboratory animal experiments is two to four orders of magnitude greater than cumulative exposure for a human during one year of outdoor work on a farm crossed by a transmission line.

Silva, J.M.

1985-04-01T23:59:59.000Z

212

Low Dose Radiation Research Program: William F. Morgan  

NLE Websites -- All DOE Office Websites (Extended Search)

William F. Morgan William F. Morgan Pacific Northwest National Laboratory PO Box 999 Richland, Washington About this Project Projects Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Genetic Factors Affecting Susceptibility to Low-Dose Radiation Mechanisms of Adaptive Responses and Genomic Instability Induced by Low Dose/ Low Dose Rate Radiation Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Genetic Factors Affecting Susceptibility to Low-Dose Radiation

213

A two dimensional modeling study of the sensitivity of ozone to radiative flux uncertainties  

Science Conference Proceedings (OSTI)

Radiative processes strongly effect equilibrium trace gas concentrations both directly, through photolysis reactions, and indirectly through temperature and transport processes. We have used the LLNL 2-D chemical-radiative-transport model to investigate the net sensitivity of equilibrium ozone concentrations to several changes in radiative forcing. Doubling CO/sub 2/ from 300 ppmv to 600 ppmv resulted in a temperature decrease of 5 K to 8 K in the middle stratosphere along with an 8% to 16% increase in ozone in the same region. Replacing our usual shortwave scattering algorithms with a simplified Rayleigh algorithm led to a 1% to 2% increase in ozone in the lower stratosphere. Finally, modifying our normal CO/sub 2/ cooling rates by corrections derived from line-by-line calculations resulted in several regions of heating and cooling. We observed temperature changes on the order of 1 K to 1.5 K with corresponding changes of 0.5% to 1.5% in O/sub 3/. Our results for doubled CO/sub 2/ compare favorably with those by other authors. Results for our two perturbation scenarios stress the need for accurately modeling radiative processes while confirming the general validity of current models. 15 refs., 5 figs.

Grant, K.E.; Wuebbles, D.J.

1988-08-01T23:59:59.000Z

214

Defining Top-of-the-Atmosphere Flux Reference Level for Earth Radiation Budget Studies  

Science Conference Proceedings (OSTI)

To estimate the earth's radiation budget at the top of the atmosphere (TOA) from satellite-measured radiances, it is necessary to account for the finite geometry of the earth and recognize that the earth is a solid body surrounded by a ...

Norman G. Loeb; Seiji Kato; Bruce A. Wielicki

2002-11-01T23:59:59.000Z

215

Human health issues for plutonium inhalation: Perspectives from laboratory animal studies  

SciTech Connect

Since the first production of plutonium in the 1940s, potential health effects from plutonium have been a concern for humans. The few people exposed to plutonium and the relatively small intakes that have occurred, at least in the Western world, have resulted in very little direct information from human population studies. The Manhattan Project workers have been followed for decades, and few health effects have been observed. The situation is similar for the population of workers at the Rocky Flats facility. Some information is now being released from the former Soviet Union on selected worker populations who show biological effects, primarily pulmonary fibrosis and some increase in lung cancers.

Muggenburg, B.A.; Hahn, F.F.; Guilmette, R.A. [Lovelace Respiratory Research Institute, Albuquerque, NM (United States)] [and others

1997-12-01T23:59:59.000Z

216

Effects of atomic radiation  

SciTech Connect

This book focuses on the lifelong effects of atomic radiation exposure in language understandable by the concerned layperson or the specialist in another field. The base of knowledge used is the work of the Atomic Bomb Casualty Commission and its successor since 1975 the Radiation Effects Research Foundation. Within the range of Chronic effects on human health the book provides a thorough review, although effects of nonionizing radiation, effects on structures, effects on other living species, and acute effects are not discussed.

Schull, W.J.

1995-12-31T23:59:59.000Z

217

Risk of Low Dose/Low Dose Rate Ionizing Radiation to Humans Symposium at the EMS 2009 Annual Meeting - September 2006  

Science Conference Proceedings (OSTI)

The low dose symposium thoughtfully addressed controversy of risk from low dose radiation exposure, hormesis and radon therapy. The stem cell symposium cogently considered the role of DNA damage and repair in hematopoietic stem cells underlying aging and malignancy and provocatively presented evidence that stem cells may have distinct morphologies and replicative properties, as well as special roles in cancer initiation. In the epigenetics symposium, studies illustrated the long range interaction of epigenetic mechanisms, the roles of CTCF and BORIS in region/specific regulation of epigenetic processes, the impact of DNA damage on epigenetic processes as well as links between epigenetic mechanisms and early nutrition and bystander effects.

Morgan, William F.; von Borstel, Robert C.; Brenner,; Redpath, J. Leslie; Erickson, Barbra E.; Brooks,

2009-11-12T23:59:59.000Z

218

Transport and Mixing Patterns over Central California during the Carbonaceous Aerosol and Radiative Effects Study (CARES)  

SciTech Connect

We describe the synoptic and regional-scale meteorological conditions that affected the transport and mixing of trace gases and aerosols in the vicinity of Sacramento, California during June 2010 when the Carbonaceous Aerosol and Radiative Effects Study (CARES) was conducted. The meteorological measurements collected by various instruments deployed during the campaign and the performance of the chemistry version of the Weather Research and Forecasting model (WRF-Chem) are both discussed. WRF-Chem was run daily during the campaign to forecast the spatial and temporal variation of carbon monoxide emitted from 20 anthropogenic source regions in California to guide aircraft sampling. The model is shown to reproduce the overall circulations and boundary-layer characteristics in the region, although errors in the upslope wind speed and boundary-layer depth contribute to differences in the observed and simulated carbon monoxide. Thermally-driven upslope flows that transported pollutants from Sacramento over the foothills of the Sierra Nevada occurred every afternoon, except during three periods when the passage of mid-tropospheric troughs disrupted the regional-scales flow patterns. The meteorological conditions after the passage of the third trough were the most favorable for photochemistry and likely formation of secondary organic aerosols. Meteorological measurements and model forecasts indicate that the Sacramento pollutant plume was likely transported over a downwind site that collected trace gas and aerosol measurements during 23 periods; however, direct transport occurred during only eight of these periods. The model also showed that emissions from the San Francisco Bay area transported by intrusions of marine air contributed a large fraction of the carbon monoxide in the vicinity of Sacramento, suggesting that this source likely affects local chemistry. Contributions from other sources of pollutants, such as those in the Sacramento Valley and San Joaquin Valley, were relatively low. Aerosol layering in the free troposphere was observed during the morning by an airborne Lidar; WRF-Chem forecasts showed that mountain venting processes contributed to aged pollutants aloft in the valley atmosphere which then can be entrained into the growing boundary layer the subsequent day.

Fast, Jerome D.; Gustafson, William I.; Berg, Larry K.; Shaw, William J.; Pekour, Mikhail S.; Shrivastava, ManishKumar B.; Barnard, James C.; Ferrare, R.; Hostetler, Chris A.; Hair, John; Erickson, Matthew H.; Jobson, Tom; Flowers, Bradley; Dubey, Manvendra K.; Springston, Stephen R.; Pirce, Bradley R.; Dolislager, Leon; Pederson, J. R.; Zaveri, Rahul A.

2012-02-17T23:59:59.000Z

219

Transport and mixing patterns over Central California during the carbonaceous aerosol and radiative effects study (CARES)  

SciTech Connect

We describe the synoptic and regional-scale meteorological conditions that affected the transport and mixing of trace gases and aerosols in the vicinity of Sacramento, California during June 2010 when the Carbonaceous Aerosol and Radiative Effects Study (CARES) was conducted. The meteorological measurements collected by various instruments deployed during the campaign and the performance of the chemistry version of the Weather Research and Forecasting model (WRF-Chem) are both discussed. WRF-Chem was run daily during the campaign to forecast the spatial and temporal variation of carbon monoxide emitted from 20 anthropogenic source regions in California to guide aircraft sampling. The model is shown to reproduce the overall circulations and boundary-layer characteristics in the region, although errors in the upslope wind speed and boundary-layer depth contribute to differences in the observed and simulated carbon monoxide. Thermally-driven upslope flows that transported pollutants from Sacramento over the foothills of the Sierra Nevada occurred every afternoon, except during three periods when the passage of mid-tropospheric troughs disrupted the regional-scale flow patterns. The meteorological conditions after the passage of the third trough were the most favorable for photochemistry and likely formation of secondary organic aerosols. Meteorological measurements and model forecasts indicate that the Sacramento pollutant plume was likely transported over a downwind site that collected trace gas and aerosol measurements during 23 time periods; however, direct transport occurred during only eight of these periods. The model also showed that emissions from the San Francisco Bay area transported by intrusions of marine air contributed a large fraction of the carbon monoxide in the vicinity of Sacramento, suggesting that this source likely affects local chemistry. Contributions from other sources of pollutants, such as those in the Sacramento Valley and San Joaquin Valley, were relatively low. Aerosol layering in the free troposphere was observed during the morning by an airborne Lidar. WRF-Chem forecasts showed that mountain venting processes contributed to aged pollutants aloft in the valley atmosphere that are then entrained into the growing boundary layer the subsequent day.

Fast J. D.; Springston S.; GustafsonJr., W. I.; Berg, L. K.; Shaw, W. J.; Pekour, M.; Shrivastava, M.; Barnard, J. C.; Ferrare, R. A.; Hostetler, C. A.; Hair, J. A.; Erickson, M.; Jobson, B. T.; Flowers, B.; Dubey, M. K.; Pierce, R. B.; Dolislager, L.; Pederson, J.; Zaveri, R. A.

2012-02-17T23:59:59.000Z

220

A study of thermal cycling and radiation effects on indium and solder bump bonding  

Science Conference Proceedings (OSTI)

The BTeV hybrid pixel detector is constructed of readout chips and sensor arrays which are developed separately. The detector is assembled by flip-chip mating of the two parts. This method requires the availability of highly reliable, reasonably low cost fine-pitch flip-chip attachment technology. We have tested the quality of two bump-bonding technologies; indium bumps (by Advanced Interconnect Technology Ltd. (AIT) of Hong Kong) and fluxless solder bumps (by MCNC in North Carolina, USA). The results have been presented elsewhere[1]. In this paper we describe tests we performed to further evaluate these technologies. We subjected 15 indium bump-bonded and 15 fluxless solder bump-bonded dummy detectors through a thermal cycle and then a dose of radiation to observe the effects of cooling, heating and radiation on bump-bonds.

Selcuk Cihangir et al.

2001-09-12T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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221

Scalable, hydrodynamic and radiation-hydrodynamic studies of neutron stars mergers  

Science Conference Proceedings (OSTI)

We discuss the high performance computing issues involved in the numerical simulation of binary neutron star mergers and supernovae. These phenomena, which are of great interest to astronomers and physicists, can only be described by modeling the gravitational ... Keywords: BiCG, Cray T3E, Silicon Graphics Origin 2000, astronomy, astrophysics, binary neutron stars, eulerian, fluid dynamics, gravitational field, hydrodynamics, iterative methods, linear systems, multidimensions, neutron star, parallel computing, precondition, radiation transport

F. Douglas Swesty; Paul Saylor; Dennis C. Smolarski; E. Y. M. Wang

1997-11-01T23:59:59.000Z

222

In-situ Synchrotron Radiation X-ray Scattering Study On The Initial Structure Of Atomic Layer Deposition  

Science Conference Proceedings (OSTI)

Due to the excellent conformality of ALD, it is not only adopted thin film, but also has been adopted for the fabrication of nanostructures. The surface reaction of ALD process is dependent on the substrate condition, thus the study on initial stage of ALD process is crucial to achieve controllable film growth. By the way, because of quite low scattering intensity of initial ultra thin layer, the high flux Synchrotron Radiation is needed. Synchrotron radiation x-ray scattering measurements allow us to investigate the atomic structure evolution of a few nanometer thickness films at the initial growth stage, nondestructively. Ru and TaN ALD films were grown. The thickness, roughness, and electron density were estimated by X-Ray Reflectivity (XRR) analysis. The island structures and its coverage also were estimated.

Park, Y. J. [Pohang Accelerator Laboratory, POSTECH, Pohang, Gyeongbuk (Korea, Republic of); Department of MSE, POSTECH, Pohang, Gyeongbuk (Korea, Republic of); Lee, D. R. [Department of Physics, Soongsil univ., Seoul (Korea, Republic of); Baik, S. [Department of MSE, POSTECH, Pohang, Gyeongbuk (Korea, Republic of)

2011-12-23T23:59:59.000Z

223

A Study of the Solar Radiation Effect on the 4.3-?m Channels of the High-Resolution Infrared Radiation Sounder  

Science Conference Proceedings (OSTI)

Measurements of infrared radiation from the National Oceanic and Atmospheric Administration series of satellites are used to retrieve atmospheric temperature, moisture, and ozone. It is well known that the measurements from the 4.3-?m channels of ...

Larry M. McMillin; David S. Crosby

2000-10-01T23:59:59.000Z

224

Comparative Study of Different {beta}-Radiation Doses for Preventing Pterygium Recurrence  

SciTech Connect

Purpose: To compare the pterygium recurrence rates after treatment with two different {beta}-radiation doses. Methods and Materials: A total of 84 patients with a mean age of 63.0 {+-} 10.3 years (men, 48 eyes, and women, 47 eyes) and initially treated with {beta}-radiation after pterygium excision were recruited. The mean follow-up period was 49.9 {+-} 51.3 months. The patients were assigned to two dose groups: a high-dose (40 Gy) or a low-dose (20 Gy) group. The statistical significance of differences in patient age, pterygium size, and interval between surgery and radiotherapy were analyzed in the 20-Gy group using the Cox proportional hazard model at p < .05. Results: The high- and low-dose groups included 28 and 67 eyes, respectively. Pterygia recurred in 11 eyes, all in the low-dose group. The interval between surgery and radiotherapy was not a significant predictor of recurrence. Smaller pterygia had a lower risk of recurrence than pterygia that had encroached the pupillary area (pterygium located within one-third of the corneal radius from the limbus, corrected hazard ratio [HR], 0.069; 95% confidence interval [CI], 0.006-0.766; p = .030; pterygium extending beyond one-third of the corneal radius, corrected HR, 0.188; 95% CI, 0.018-0.696; p = 0.019; and pterygium reaching the pupillary area, corrected HR, 0.184; 95% CI, 0.036-0.929; p = .040). Older age was marginally significant as a negative predictor of recurrence (HR, 0.943; 95% CI, 0.887-1.003; p = .061). No scleromalacia developed during the follow-up period. Conclusions: {beta}-Radiation at 40 Gy was more efficacious than at 20 Gy in preventing pterygium recurrence without scleromalacia development, particularly for large-size pterygia and those in young patients.

Yamada, Takayuki, E-mail: tyamada-oph@umin.ac.jp [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Mochizuki, Hideki [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Ue, Takahiro [Department of Ophthalmology, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima (Japan); Kiuchi, Yoshiaki [Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima (Japan); Takahashi, Yasuhiro [Department of Ophthalmology and Visual Science, Aichi Medical University School of Medicine, Aichi (Japan); Oinaka, Matsuyoshi [Department of Ophthalmology, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima (Japan)

2011-12-01T23:59:59.000Z

225

Development and characterization of a novel variable low-dose rate irradiator for in vivo mouse studies  

E-Print Network (OSTI)

Radiation exposure of humans generally results in low doses delivered at low dose rate. Our limited knowledge of the biological effects of low dose radiation is mainly based on data from the atomic bomb Life Span Study ...

Davidson, Matthew Allen

226

Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study  

SciTech Connect

The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to translate the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

Ronald L. Boring; John A. Forester; Andreas Bye; Vinh N. Dang; Erasmia Lois

2010-06-01T23:59:59.000Z

227

Does Local Recurrence of Prostate Cancer After Radiation Therapy Occur at the Site of Primary Tumor? Results of a Longitudinal MRI and MRSI Study  

Science Conference Proceedings (OSTI)

Purpose: To determine if local recurrence of prostate cancer after radiation therapy occurs at the same site as the primary tumor before treatment, using longitudinal magnetic resonance (MR) imaging and MR spectroscopic imaging to assess dominant tumor location. Methods and Materials: This retrospective study was HIPAA compliant and approved by our Committee on Human Research. We identified all patients in our institutional prostate cancer database (1996 onward) who underwent endorectal MR imaging and MR spectroscopic imaging before radiotherapy for biopsy-proven prostate cancer and again at least 2 years after radiotherapy (n = 124). Two radiologists recorded the presence, location, and size of unequivocal dominant tumor on pre- and postradiotherapy scans. Recurrent tumor was considered to be at the same location as the baseline tumor if at least 50% of the tumor location overlapped. Clinical and biopsy data were collected from all patients. Results: Nine patients had unequivocal dominant tumor on both pre- and postradiotherapy imaging, with mean pre- and postradiotherapy dominant tumor diameters of 1.8 cm (range, 1-2.2) and 1.9 cm (range, 1.4-2.6), respectively. The median follow-up interval was 7.3 years (range, 2.7-10.8). Dominant recurrent tumor was at the same location as dominant baseline tumor in 8 of 9 patients (89%). Conclusions: Local recurrence of prostate cancer after radiation usually occurs at the same site as the dominant primary tumor at baseline, suggesting supplementary focal therapy aimed at enhancing local tumor control would be a rational addition to management.

Arrayeh, Elnasif; Westphalen, Antonio C. [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Kurhanewicz, John [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Roach, Mack [Department of Radiation Oncology, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Jung, Adam J. [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Carroll, Peter R. [Department of Urology, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States); Coakley, Fergus V., E-mail: fergus.coakley@radiology.ucsf.edu [Department of Radiology and Biomedical Imaging, University of California San Francisco, California (United States); Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, California (United States)

2012-04-01T23:59:59.000Z

228

A Study to Increase Participation of Habitat for Humanity Affiliates in LEED for Homes Certification  

E-Print Network (OSTI)

In the United States, Habitat for Humanity is at the forefront of the providing affordable housing to low income homeowners. Because of this work, Habit for Humanity is one of the leading homebuilders in the United States. A recent development in the assessment of home building is an increased emphasis on the use of technology and methods that reduce the impact of housing construction and occupation on the worlds environment. Numerous methods exist to assess this impact, a major one in the United States is the LEED system developed by the US Green Building Council. Two problems exist with the LEED system, one being cost and the time of preparation of the necessary paperwork. Other research work exists on these implementation problems for the broader community, but this study looks at the specific impact and impediments to obtaining LEED certification for Habit for Humanity housing, specifically in Texas. This study assesses Habit for Humanity affiliates involvement with LEED and sustainable building. This is accomplished in two parts, a survey and an analysis of LEED scorecards. To gauge the current state of sustainable building in Habitat for Humanity affiliates of Texas a survey was conducted. There were 15 participants out of 84 affiliates. The survey looked in to the current sustainable practices and barriers for the affiliates to participate in the LEED program. Then LEED score cards were obtained and analyzed, eleven scorecards total were obtained. Six scorecards were from homes built by Habitat for Humanity affiliates across the United States, and the other five scorecards came from a production home builder in Texas. The scorecards were then compared by determining the mean of points for each question. From this case study, the survey shows cost and knowledge to be the largest barriers to LEED certification. The data from the LEED scorecards showed Water Efficiency and Indoor Environmental Quality to be the two weakest categories for the HFH affiliates compared to the production homes. These barriers can potentially be overcome by the availability of grants for sustainable building and by educating the affiliates on LEED and sustainable building. The fact that HFH is a leader in affordable housing means if HFH affiliates can build to LEED standard so can other affordable builders.

Rabb, Amy Elizabeth

2013-05-01T23:59:59.000Z

229

About Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation What is radiation? Radiation is a form of energy that is a part of our everyday lives. All of us receive a "dose" of radiation each day. Most of the dose comes from...

230

A study of thermal cycling and radiation effects on indium and solder bump bonds  

Science Conference Proceedings (OSTI)

The BTeV hybrid pixel detector is constructed of readout chips and sensor arrays which are developed separately. The detector is assembled by flip-chip mating of the two parts. This method requires the availability of highly reliable, reasonably low cost fine-pitch flip-chip attachment technology. We have tested the quality of two bump-bonding technologies; indium bumps (by Advanced Interconnect Technology Ltd. (AIT) of Hong Kong) and fluxless solder bumps (by MCNC in North Carolina, USA). The results have been presented elsewhere [1]. In this paper we describe tests we performed to further evaluate these technologies. We subjected 15 indium bump-bonded and 15 fluxless solder bump-bonded dummy detectors through a thermal cycle and then a dose of radiation to observe the effects of cooling, heating and radiation on bump-bonds. We also exercised the processes of HDI mounting and wire bonding to some of the dummy detectors to see the effect of these processes on bump bonds.

Simon Kwan et al.

2001-12-11T23:59:59.000Z

231

Radiation Measurements 42 (2007) 10291032 www.elsevier.com/locate/radmeas  

E-Print Network (OSTI)

for internalized DU exposure. The purpose of the current study was to measure the induction of mutagenic damageRadiation Measurements 42 (2007) 1029­1032 www.elsevier.com/locate/radmeas Observation of radiation demonstrated that DU exposure in vitro to immortalized human osteoblast cells (HOS) is both neoplastically

232

Study of radiation effects on the cell structure and evaluation of the dose delivered by x-ray and {alpha}-particles microscopy  

SciTech Connect

Hard X-ray fluorescence microscopy and magnified phase contrast imaging are combined to study radiation effects on cells. Experiments were performed on freeze-dried cells at the nano-imaging station ID22NI of the European synchrotron radiation facility. Quantitative phase contrast imaging provides maps of the projected mass and is used to evaluate the structural changes due to irradiation during X-ray fluorescence experiments. Complementary to phase contrast imaging, scanning transmission ion microscopy is performed and doses of all the experiments are compared. We demonstrate the sensitivity of the proposed approach to study radiation-induced damage at the sub-cellular level.

Kosior, Ewelina; Cloetens, Peter [European Synchrotron Radiation Facility, F-38000 Grenoble (France); Deves, Guillaume; Ortega, Richard [Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan (France); CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan (France); Bohic, Sylvain [European Synchrotron Radiation Facility, 38000 Grenoble (France); INSERM U-836 (Team 6: Synchrotron Radiation and Medical Research), Grenoble Institut of Neuroscience, F-38000 Grenoble (France)

2012-12-24T23:59:59.000Z

233

Cocoa Butter and Related CompoundsChapter 14 New Method to Study Molecular Interactions in FatsSynchrotron Radiation Microbeam X-ray Diffraction  

Science Conference Proceedings (OSTI)

Cocoa Butter and Related Compounds Chapter 14 New Method to Study Molecular Interactions in FatsSynchrotron Radiation Microbeam X-ray Diffraction Food Science Health Nutrition eChapters Food Science & Technology Health - Nutrition - Bioc

234

Parameter study of tropical cyclones in rotating radiative-convective equilibrium with column physics and resolution of a 25 km GCM  

Science Conference Proceedings (OSTI)

Rotating radiative-convective equilibrium is studied by extracting the column physics of a meso-scale resolution global atmospheric model that simulates realistic hurricane frequency statistics and coupling it to rotating hydrostatic dynamics in ...

Wenyu Zhou; Isaac M. Held; Stephen T. Garner

235

Radiation-induced leukemia: Comparative studies in mouse and man. Annual performance report, June 1, 1991--October 31, 1991  

SciTech Connect

We now have a clear understanding of the mechanism by which radiation-induced (T-cell) leukemia occurs. In irradiated mice (radiation-induced thymic leukemia) and in man (acute lymphoblastic T-cell leukemia, T-ALL) the mechanism of leukemogenesis is surprisingly similar. Expressed in the most elementary terms, T-cell leukemia occurs when T-cell differentiation is inhibited by a mutation, and pre-T cells attempt but fail to differentiate in the thymus. Instead of leaving the thymus for the periphery as functional T-cells they continue to proliferate in the thymus. The proliferating pre- (pro-) T-cells constitute the (early) acute T-cell leukemia (A-TCL). This model for the mechanism of T-cell leukemogenesis accounts for all the properties of both murine and human A-TCL. Important support for the model has recently come from work by Ilan Kirsch and others, who have shown that mutations/deletions in the genes SCL (TAL), SIL, and LCK constitute primary events in the development of T-ALL, by inhibiting differentiation of thymic pre- (pro-) T-cells. This mechanism of T-cell leukemogenesis brings several specific questions into focus: How do early A-TCL cells progress to become potently tumorigenic and poorly treatable? Is it feasible to genetically suppress early and/or progressed A-TCL cells? What is the mechanism by which the differentiation-inhibited (leukemic) pre-T cells proliferate? During the first grant year we have worked on aspects of all three questions.

Haas, M.

1991-12-31T23:59:59.000Z

236

Exploratory studies of human sensorimotor learning with system identification and stochastic optimal control  

E-Print Network (OSTI)

b) Shows the average human error over one particular trialb) Shows the average human error over one particular trialIs a histogram of average human tracking error over several

Simpkins, Charles Alexander

2009-01-01T23:59:59.000Z

237

428 IEEE SYSTEMS JOURNAL, VOL. 3, NO. 4, DECEMBER 2009 Multiple Human Tracking and Identification With  

E-Print Network (OSTI)

for tracking and identifying multiple humans based on their body heat radiation. This study aims to make py428 IEEE SYSTEMS JOURNAL, VOL. 3, NO. 4, DECEMBER 2009 Multiple Human Tracking and Identification conditions, as well as a complement for conventional video and audio human tracking and identification

Hu, Fei

238

Development and Validation of a Heart Atlas to Study Cardiac Exposure to Radiation Following Treatment for Breast Cancer  

SciTech Connect

Purpose: Cardiac toxicity is an important sequela of breast radiotherapy. However, the relationship between dose to cardiac structures and subsequent toxicity has not been well defined, partially due to variations in substructure delineation, which can lead to inconsistent dose reporting and the failure to detect potential correlations. Here we have developed a heart atlas and evaluated its effect on contour accuracy and concordance. Methods and Materials: A detailed cardiac computed tomography scan atlas was developed jointly by cardiology, cardiac radiology, and radiation oncology. Seven radiation oncologists were recruited to delineate the whole heart, left main and left anterior descending interventricular branches, and right coronary arteries on four cases before and after studying the atlas. Contour accuracy was assessed by percent overlap with gold standard atlas volumes. The concordance index was also calculated. Standard radiation fields were applied. Doses to observer-contoured cardiac structures were calculated and compared with gold standard contour doses. Pre- and post-atlas values were analyzed using a paired t test. Results: The cardiac atlas significantly improved contour accuracy and concordance. Percent overlap and concordance index of observer-contoured cardiac and gold standard volumes were 2.3-fold improved for all structures (p < 0.002). After application of the atlas, reported mean doses to the whole heart, left main artery, left anterior descending interventricular branch, and right coronary artery were within 0.1, 0.9, 2.6, and 0.6 Gy, respectively, of gold standard doses. Conclusions: This validated University of Michigan cardiac atlas may serve as a useful tool in future studies assessing cardiac toxicity and in clinical trials which include dose volume constraints to the heart.

Feng, Mary, E-mail: maryfeng@umich.ed [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Moran, Jean M. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Koelling, Todd [Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chughtai, Aamer [Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Chan, June L.; Freedman, Laura; Hayman, James A.; Jagsi, Reshma; Jolly, Shruti; Larouere, Janice; Soriano, Julie; Marsh, Robin; Pierce, Lori J. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)

2011-01-01T23:59:59.000Z

239

Human Radiation Experiments: Related Sites  

NLE Websites -- All DOE Office Websites (Extended Search)

Experiment Experiment Related Sites Related Links Home Roadmap What's New Search HREX Multimedia Related Sites Federal DOE DOE Sites & National Laboratories Federal Other The following are organizations which provide related information and links to databases, electronic documents, and servers. FEDERAL - DOE U.S. Department of Energy (DOE) homepage (http://www.doe.gov/)contains information on DOE's Departmental Resources, Programs, Offices, National Labs and other DOE related topics. DOE's Environment, Safety and Health (ES&H) Technical Information Services (TIS) homepage (http://nattie.eh.doe.gov/) is a collection of information services designed to provide safety and health professionals with reliable, accurate and current information to assist them in performing their jobs.

240

A study of longwave radiation codes for climate studies: Validation with ARM observations and tests in general circulation models. Final report, September 15, 1990--October 31, 1994  

SciTech Connect

DOE has launched a major initiative -- the Atmospheric Radiation Measurements (ARM) Program -- directed at improving the parameterization of the physics governing cloud and radiative processes in general circulation models (GCMs). One specific goal of ARM is to improve the treatment of radiative transfer in GCMs under clear-sky, general overcast and broken cloud conditions. In 1990, the authors proposed to contribute to this goal by attacking major problems connected with one of the dominant radiation components of the problem -- longwave radiation. In particular, their long-term research goals are to: develop an optimum longwave radiation model for use in GCMs that has been calibrated with state-of-the-art observations, assess the impact of the longwave radiative forcing in a GCM, determine the sensitivity of a GCM to the radiative model used in it, and determine how the longwave radiative forcing contributes relatively when compared to shortwave radiative forcing, sensible heating, thermal advection and expansion.

Ellingson, R.G.; Baer, F.

1998-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Radiation environment simulations at the Tevatron, studies of the beam profile and measurement of the Bc meson mass  

Science Conference Proceedings (OSTI)

The description of a computer simulation of the CDF detector at Fermilab and the adjacent accelerator parts is detailed, with MARS calculations of the radiation background in various elements of the model due to the collision of beams and machine-related losses. Three components of beam halo formation are simulated for the determination of the principal source of radiation background in CDF due to beam losses. The effect of a collimator as a protection for the detector is studied. The simulation results are compared with data taken by a CDF group. Studies of a 150 GeV Tevatron proton beam are performed to investigate the transverse diffusion growth and distribution. A technique of collimator scan is used to scrape the beam under various experimental conditions, and computer programs are written for the beam reconstruction. An average beam halo growth speed is given and the potential of beam tail reconstruction using the collimator scan is evaluated. A particle physics analysis is conducted in order to detect the B{sub c} {yields} J/{psi}{pi} decay signal with the CDF Run II detector in 360 pb{sup -1} of data. The cut variables and an optimization method to determine their values are presented along with a criterion for the detection threshold of the signal. The mass of the B{sub c} meson is measured with an evaluation of the significance of the signal.

Nicolas, Ludovic Y.; /Glasgow U.

2005-09-01T23:59:59.000Z

242

Radiation: Radiation Control (Indiana)  

Energy.gov (U.S. Department of Energy (DOE))

It is the policy of the state to encourage the constructive uses of radiation and to control its harmful effects. This section contains regulations pertaining to the manufacture, use,...

243

A Study on the Runaway Greenhouse Effect with a One-Dimensional RadiativeConvective Equilibrium Model  

Science Conference Proceedings (OSTI)

A simple one-dimensional radiativeconvective equilibrium model is used to investigate the relationship between the surface temperature and the outgoing infrared radiation at the top of the atmosphere. The model atmosphere has a gray infrared ...

Shinichi Nakajima; Yoshi-Yuki Hayashi; Yutaka Abe

1992-12-01T23:59:59.000Z

244

A Study of CloudGenerated Radiative Heating and Its Generation of Available Potential Energy. Part I: Theoretical Background  

Science Conference Proceedings (OSTI)

The theory is presented of the effect of radiative heating and cooling by clouds on the available potential energy (APE). This provides a measure of the influence of clouds on the general circulation. Absorption and scattering of solar radiation ...

R. Stuhlmann; G. L. Smith

1988-12-01T23:59:59.000Z

245

Evaluating WRF-Chem multi-scale model in simulating aerosol radiative properties over the tropics A case study over India  

Science Conference Proceedings (OSTI)

We utilized WRF-Chem multi-scale model to simulate the regional distribution of aerosols, optical properties and its effect on radiation over India for a winter month. The model is evaluated using measurements obtained from upper-air soundings, AERONET sun photometers, various satellite instruments, and pyranometers operated by the Indian Meteorological Department. The simulated downward shortwave flux was overestimated when the effect of aerosols on radiation and clouds was neglected. Downward shortwave radiation from a simulation that included aerosol-radiation interaction processes was 5 to 25 Wm{sup -2} closer to the observations, while a simulation that included aerosol-cloud interaction processes were another 1 to 20 Wm{sup -2} closer to the observations. For the few observations available, the model usually underestimated particulate concentration. This is likely due to turbulent mixing, transport errors and the lack of secondary organic aerosol treatment in the model. The model efficiently captured the broad regional hotspots such as high aerosol optical depth over Indo-Gangetic basin as well as the northwestern and southern part of India. The regional distribution of aerosol optical depth compares well with AVHRR aerosol optical depth and the TOMS aerosol index. The magnitude and wavelength-dependence of simulated aerosol optical depth was also similar to the AERONET observations across India. Differences in surface shortwave radiation between simulations that included and neglected aerosol-radiation interactions were as high as -25 Wm{sup -2}, while differences in surface shortwave radiation between simulations that included and neglect aerosol-radiation-cloud interactions were as high as -30 Wm{sup -2}. The spatial variations of these differences were also compared with AVHRR observation. This study suggests that the model is able to qualitatively simulate the impact of aerosols on radiation over India; however, additional measurements of particulate mass and composition are needed to fully evaluate whether the aerosol precursor emissions are adequate when simulating radiative forcing in the region.

Seethala, C.; Pandithurai, G.; Fast, Jerome D.; Polade, Suraj D.; Reddy, M. S.; Peckham, Steven E.

2012-01-24T23:59:59.000Z

246

Low Dose Radiation Program: Radiation Biology and the Radiation Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and the Radiation Research Program Biology and the Radiation Research Program The Department of Energy (DOE) and its predecessor organizations, Energy Research and Development Agency (ERDA) and Atomic Energy Commission (AEC), always have been concerned about the health effects of ionizing radiation. Extensive research has been conducted under their sponsorship at all levels of biological organization from molecules to man. Over the past 60 years, studies using every type of radiation source have included exposure to both external radiation sources and to internally deposited radioactive materials. These exposures used different dose patterns and distributions delivered over a wide range of experimental times. This extensive research provided the basis for the new Low Dose Radiation Research Program, linking

247

Original Article Seroepidemiological Study of Human Hydatidosis in Meshkinshahr District, Ardabil Province, Iran  

E-Print Network (OSTI)

Background: The aim of this study was to conduct a sero-epidemiological survey in Meshkinshahr, Ardabil Province, northwestern Iran to detect the rate of hydatidosis in the city and nearby villages. Literature shows that no such study has been conducted so far. Methods: Overall, 670 serum samples were collected from 194 males and 476 females from patients referred to different health centers of the region. All patients filled out a questionnaire and an informed consent. Sera were analyzed using indirect-ELISA test. Ten ?g /ml antigens (Antigen B derived from hydatid cyst fluid), serum dilutions of 1:500 and conjugate anti-human coombs with 1:10000 dilutions were utilized to perform the test. Data analysis was conducted using SPSS software ver. 11.5. Results: The seroprevalence of human hydatidosis was 1.79 % by ELISA test in the region. This rate for females was 1.68 % and males 2.6%, respectively. There was no significant difference as regards all factors studied and the seropositivity. According to job, farmers and ranchmen had the highest rate of infection as 3.17%. The sero-prevalence of infection was 2.6% % in illiterate people which showed the highest rate. As regards residency, urban life showed no significant difference with rural life (1.1 % vs. 2.58%).

Iranian J Parasitol; Z Heidari; M Mohebali; Z Zarei; M Aryayipour; Mr Eshraghian; Eb Kia; S Shodajei; J Abdi; A Rakhshanpour; Mb Rokni

2011-01-01T23:59:59.000Z

248

Protection Against Ionizing Radiation in Extreme Radiation ...  

Science Conference Proceedings (OSTI)

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms. ... Elucidated radiation protection by intracellular halides. ...

2013-05-01T23:59:59.000Z

249

Cancer risk among children of atomic bomb survivors. A review of RERF epidemiologic studies. Radiation Effects Research Foundation  

Science Conference Proceedings (OSTI)

This article summarizes recent epidemiologic studies of cancer risk among the children of atomic bomb survivors conducted at the Radiation Effects Research Foundation. These children include two groups: (1) the in utero-exposed children (ie, those born to mothers who had been pregnant at the time of the bombings of Hiroshima and Nagasaki) and (2) the F1 population, which was conceived after the atomic-bombings and born to parents of whom one or both were atomic bomb survivors. Although from 1950 to 1984 only 18 cancer cases were identified among the in utero sample, cancer risk did appear to significantly increase as maternal uterine dose increased. However, since the observed cases are too few in number to allow a site-specific review, the increased cancer risk cannot be definitively attributed to atomic bomb radiation, as yet. For those members of the F1 population who were less than 20 years old between 1946 and 1982, cancer risk did not appear to increase significantly as parental gonadal dose increased. Follow-up of this population will continue to determine if the patterns of adult-onset cancer are altered.

Yoshimoto, Y. (Radiation Effects Research Foundation, Hiroshima (Japan))

1990-08-01T23:59:59.000Z

250

Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats  

SciTech Connect

Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

2009-04-01T23:59:59.000Z

251

Study on the radiative decays of $?(nS)\\to ?_b+?$  

E-Print Network (OSTI)

In this work, we investigate the characteristics of the spin-singlet state $\\eta_b$ of the bottomonia family via the radiative decays of $\\Upsilon(nS)\\to \\eta_b+\\gamma$. The theoretical estimation of the decay widths is carried out in terms of the light-front quark model (LFQM). Recently CLEO and BaBar collaborations have measured $\\mathcal{B}(\\Upsilon(3S)\\to\\gamma\\eta_b)$ and the mass of ${\\eta_b}$. In terms of the data we fix the concerned input parameters in our calculations of $\\Upsilon(nS)\\to \\eta_b+\\gamma$. A special attention is paid on the transition of $\\Upsilon(5S)\\to \\eta_b+\\gamma$. The BELLE data showed that the width of $\\Upsilon(5S)\\to \\Upsilon(2S,1S)+\\pi\\pi$ is two orders larger than that of $\\Upsilon(4S)\\to \\Upsilon(2S,1S)+\\pi\\pi$, thus some theoretical explanations have been proposed. Among them, it is suggested the inelastic final state interaction (IFSI) $\\Upsilon(5S)\\to B\\bar B\\to \\Upsilon(1S)+\\pi\\pi$ may be a natural one. If so, a similar mechanism also applies to $\\Upsilon(5S)\\to B^{(*)}\\bar B^{(*)}\\to \\eta_b+\\gamma$, the precise measurement would serve as a good test whether $\\Upsilon(5S)$ possess exotic components. Our calculation in the LFQM indicates that the rate of the direct process $\\Upsilon(5S)\\to\\eta_b+\\gamma$ is not anomalous compared to $\\Upsilon(mS)\\to\\eta_b+\\gamma (m=1,2,3,4)$, thus if the IFSI does apply, the rate of $\\Upsilon(5S)\\to\\eta_b+\\gamma$ should be larger than the others by orders.

Hong-Wei Ke; Xue-Qian Li; Xiang Liu

2010-02-05T23:59:59.000Z

252

Flaxseed in Human Nutrition, 2nd EditionChapter 15 Flaxseed, Fiber and Coronary Heart Disease: Clinical Studies  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 15 Flaxseed, Fiber and Coronary Heart Disease: Clinical Studies Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry Press

253

Head-and-Neck Target Delineation Among Radiation Oncology Residents After a Teaching Intervention: A Prospective, Blinded Pilot Study  

Science Conference Proceedings (OSTI)

Purpose: We conducted this study to determine the feasibility of incorporating a teaching intervention on target delineation into the educational curriculum of a radiation oncology residency program and to assess the short-term effects on resident skills. Methods and Materials: The study schema consisted of a baseline evaluation, the teaching intervention, and a follow-up evaluation. At the baseline evaluation, the participants contoured three clinical tumor volumes (CTVs) (70 Gy, 59.4 Gy, and 54 Gy) on six contrast-enhanced axial computed tomography images of a de-identified patient with Stage T2N2bM0 squamous cell carcinoma of the right base of the tongue. The participants attended a series of head-and-neck oncology and anatomy seminars. The teaching intervention consisted of a didactic lecture and an interactive hands-on practical session designed to improve the knowledge and skills for target delineation in the head and neck. At the follow-up evaluation, the residents again contoured the CTVs. Results: Of the 14 eligible residents, 11 (79%) actually participated in the study. For all participants, but especially for those who had not had previous experience with head-and-neck target delineation, the teaching intervention was associated with improvement in the delineation of the node-negative neck (CTV 54 Gy contour). Regardless of clinical experience, participants had difficulty determining what should be included in the CTV 59.4 Gy contour to ensure adequate coverage of potential microscopic disease. Conclusion: Incorporating a teaching intervention into the education curriculum of a radiation oncology residency program is feasible and was associated with short-term improvements in target delineation skills. Subsequent interventions will require content refinement, additional validation, longer term follow-up, and multi-institutional collaboration.

Bekelman, Justin E. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)], E-mail: bekelmaj@mskcc.org; Wolden, Suzanne; Lee, Nancy [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2009-02-01T23:59:59.000Z

254

RADIATION MONITORING  

E-Print Network (OSTI)

of Monitoring for Radiation Protection of Workers" in ICRPNo. 9, in "Advances in Radiation Protection and Dosimetry inDosimetry f o r Stray Radiation Monitoring on the CERN S i t

Thomas, R.H.

2010-01-01T23:59:59.000Z

255

Radiation and viral DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation and viral DNA Radiation and viral DNA Name: Loretta L Lamb Age: N/A Location: N/A Country: N/A Date: N/A Question: Can viral DNA be changed through exposure to radiation? If so, what type of radiation will do this? Can these irradiated viruses cause changes in the genome of any human cells they may infect? Can these (or any) viruses actually cause cancer, or do they merely act as triggering devices for cancer? Replies: In theory, any nucleic acid (viral or otherwise) can be changed by exposure to many kinds of radiation. Depending on the type of virus, these may then change the human cells that they infect. Although there are many different things that are being implicated in causing cancers, it looks like a fairly common model involves the sequential "knockout" of several human genes. Viruses may be one cause of such gene changes, radiation and other environmental causes may also contribute. Some of these changes may be inherited through families, so it becomes more likely that the environmental factors may happen to "hit" the right places in cells to cause cancers in these families. If you ask something more specific, perhaps I can focus my response a bit more

256

Carbonaceous Aerosols and Radiative...  

NLE Websites -- All DOE Office Websites (Extended Search)

Aerosols and Radiative Effects Study Science Objective This field campaign is designed to increase scientific knowledge about the evolution of black carbon, primary organic...

257

BNL NASA Space Radiation Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Purpose: To use beams of heavy ions provided by the Booster accelerator at Brookhaven to study the effects of simulated space radiation on biological and physical systems, with the goal of developing methods and materials to reduce the risk to human beings on prolonged space missions of the effects of ionizing radiation Sponsor: National Aeronautics and Space Administration (NASA) Project cost $34 million over 4 years Operating costs Nearly $8 million per year in 2007 Features * beams of heavy ions extracted from the Booster accelerator with masses and energies similar to the cosmic rays encountered in space: * 1-billion electron volt (GeV)/nucleon iron-56 * 0.3-GeV/nucleon gold-97 * 0.6-GeV/nucleon silicon-28 * 1-GeV/nucleon protons * 1-GeV/nucleon titanium

258

Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland  

Science Conference Proceedings (OSTI)

Purpose: To elucidate with a histopathological study the mechanism of region-dependent volume effects in the partly irradiated parotid gland of the rat. Methods and Materials: Wistar rats were locally X-irradiated with collimators with conformal radiation portals for 100% volume and 50% cranial/caudal partial volumes. Single doses up to 40 Gy were applied. Parotid saliva samples were collected, and the three lobes of the parotid gland were examined individually on the macro- and micromorphologic level up to 1 year after irradiation. Results: Dose-dependent loss of gland weight was observed 1 year after total or partial X-irradiation. Weight loss of the glands correlated very well with loss of secretory function. Irradiating the cranial 50% volume (implicating a shielded lateral lobe) resulted in substantially more damage in terms of weight loss and loss of secretory function than 50% caudal irradiation (shielding the ventral and dorsal lobe). Histologic examinations of the glands 1 year after irradiation revealed that the shielded lateral lobe was severely affected, in contrast to the shielded ventral and dorsal lobes. Time studies showed that irradiation of the cranial 50% volume caused late development of secondary damage in the shielded lateral lobe, becoming manifest between 240 and 360 days after irradiation. The possible clinical significance of this finding is discussed. Conclusion: It is concluded that the observed region-dependent volume effect for late function loss in the rat parotid gland after partial irradiation is mainly caused by secondary events in the shielded lateral lobe. The most probable first step (primary radiation event) in the development of this secondary damage is radiation exposure to the hilus region (located between the ventral and dorsal lobe). By injuring major excretory ducts and supply routes for blood and nerves in this area, the facility system necessary for proper functioning of the nonexposed lateral lobe is seriously affected. The unexpected volume effect in the rat might have consequences for treatment strategies in radiotherapy, implicating not only salivary glands but also other organs with a seemingly homogeneous distribution of radiosensitive elements, a situation wherein volume effects have not been anticipated up to now.

Konings, Antonius W.T. [Department of Radiation and Stress Cell Biology, University Medical Center Groningen, Groningen (Netherlands)]. E-mail: a.w.t.konings@med.umcg.nl; Faber, Hette [Department of Radiation and Stress Cell Biology, University Medical Center Groningen, Groningen (Netherlands); Cotteleer, Femmy [Department of Radiation and Stress Cell Biology, University Medical Center Groningen, Groningen (Netherlands); Vissink, Arjan [Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen (Netherlands); Coppes, Rob P. [Department of Radiation and Stress Cell Biology, University Medical Center Groningen, Groningen (Netherlands); Department of Radiation Oncology, University Medical Center Groningen, Groningen (Netherlands)

2006-01-01T23:59:59.000Z

259

Patterns of Radiotherapy Practice for Pancreatic Cancer in Japan: Results of the Japanese Radiation Oncology Study Group (JROSG) Survey  

Science Conference Proceedings (OSTI)

Purpose: To determine the patterns of radiotherapy practice for pancreatic cancer in Japan. Methods and Materials: A questionnaire-based national survey of radiotherapy for pancreatic cancer treated between 2000 and 2006 was conducted by the Japanese Radiation Oncology Study Group (JROSG). Detailed information on 870 patients from 34 radiation oncology institutions was accumulated. Results: The median age of all patients was 64 years (range, 36-88), and 80.2% of the patients had good performance status. More than 85% of patients had clinical Stage T3-T4 disease, and 68.9% of patients had unresectable disease at diagnosis. Concerning radiotherapy (RT), 49.8% of patients were treated with radical external beam RT (EBRT) (median dose, 50.4 Gy), 44.4% of patients were treated with intraoperative RT (median dose, 25 Gy) with or without EBRT (median dose, 45 Gy), and 5.9% of patients were treated with postoperative radiotherapy (median dose, 50 Gy). The treatment field consisted of the primary tumor (bed) only in 55.6% of the patients. Computed tomography-based treatment planning and conformal RT was used in 93.1% and 83.1% of the patients treated with EBRT, respectively. Chemotherapy was used for 691 patients (79.4%; before RT for 66 patients; during RT for 531; and after RT for 364). Gemcitabine was the most frequently used drug, followed by 5-fluorouracil. Conclusion: This study describes the general patterns of RT practice for pancreatic cancer in Japan. Most patients had advanced unresectable disease, and radical EBRT, as well as intraoperative RT with or without EBRT, was frequently used. Chemotherapy with gemcitabine was commonly used in conjunction with RT during the survey period.

Ogawa, Kazuhiko, E-mail: kogawa@med.u-ryukyu.ac.j [Department of Radiology, University of the Ryukyus, Okinawa (Japan); Ito, Yoshinori [Department of Radiation Oncology, National Cancer Center, Tokyo (Japan); Karasawa, Katsuyuki [Department of Radiation Oncology, Tokyo Metropolitan Komagome Hospital, Tokyo (Japan); Ogawa, Yoshihiro [Department of Radiation Oncology, Tohoku University, Sendai (Japan); Onishi, Hiroshi [Department of Radiology, Yamanashi University, Yamanashi (Japan); Kazumoto, Tomoko [Department of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Shibuya, Keiko [Department of Radiation Oncology and Image-Applied Therapy, Kyoto University, Kyoto (Japan); Shibuya, Hitoshi [Department of Radiology, Tokyo Medical and Dental University, Tokyo (Japan); Okuno, Yoshishige [Department of Radiation Oncology, Kobe City Medical Center General Hospital, Kobe (Japan); Nishino, Shigeo [Department of Radiation Oncology, Sapporo Kosei General Hospital, Sapporo (Japan); Ogo, Etsuyo [Department of Radiology, Kurume University, Kurume (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane Medical University, Shimane (Japan); Karasawa, Kumiko [Department of Radiation Oncology, Juntendo University, Tokyo (Japan); Nemoto, Kenji [Department of Radiation Oncology, Yamagata University, Yamagata (Japan); Nishimura, Yasumasa [Department of Radiation Oncology, Kinki University School of Medicine, Osaka (Japan)

2010-07-01T23:59:59.000Z

260

Radiation Therapy After Breast-Conserving Surgery: Does Hospital Surgical Volume Matter? A Population-Based Study in Taiwan  

SciTech Connect

Purpose: To examine the association between hospital surgical volume and the use of radiation therapy (RT) after breast-conserving surgery (BCS) in Taiwan. Methods and Materials: We used claims data from the National Health Insurance program in Taiwan (1997-2005) in this retrospective population-based study. We identified patients with breast cancer, receipt of BCS, use of radiation, and the factors that could potentially associated with the use of RT from enrollment records, and the ICD-9 and billing codes in claims. We conducted logistic regression to examine factors associated with RT use after BCS, and performed subgroup analyses to examine whether the association differs by medical center status or hospital volumes. Results: Among 5,094 patients with newly diagnosed invasive breast cancer who underwent BCS, the rate of RT was significantly lower in low-volume hospitals (74% vs. 82%, p < 0.01). Patients treated in low-volume hospitals were less likely to receive RT after BCS (odds ratio = 0.72, 95% confidence interval = 0.62-0.83). In addition, patients treated after the implementation of the voluntary pay-for-performance policy in 2001 were more likely to receive RT (odds ratio = 1.23; 95% confidence interval = 1.05-1.45). Subgroup analyses indicated that the high-volume effect was limited to hospitals accredited as non-medical centers, and that the effect of the pay-for-performance policy was most pronounced among low-volume hospitals. Conclusions: Using population-based data from Taiwan, our study concluded that hospital surgical volume and pay-for-performance policy are positively associated with RT use after BCS.

Chien, Chun-Ru [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Pan, I-Wen [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Tsai, Yi-Wen [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Institute of Health and Welfare Policy, National Yang-Ming University Hospital, Taipei, Taiwan (China); Tsai, Teressa [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Liang, Ji-An [Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Shih, Ya-Chen Tina, E-mail: yashih@mdanderson.org [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States)

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

The Experimental Cloud Lidar Pilot Study (ECLIPS) for CloudRadiation Research  

Science Conference Proceedings (OSTI)

The Experimental Cloud Lidar Pilot Study (ECLIPS) was initiated to obtain statistics on cloud-base height, extinction, optical depth, cloud brokenness, and surface fluxes. Two observational phases have taken place, in October-December 1989 and ...

C. M. Platt; S. A. Young; A. I. Carswell; S. R. Pal; M. P. McCormick; D. M. Winker; M. DelGuasta; L. Stefanutti; W. L. Eberhard; M. Hardesty; P. H. Flamant; R. Valentin; B. Forgan; G. G. Gimmestad; H. Jger; S. S. Khmelevtsov; I. Kolev; B. Kaprieolev; Da-ren Lu; K. Sassen; V. S. Shamanaev; O. Uchino; Y. Mizuno; U. Wandinger; C. Weitkamp; A. Ansmann; C. Wooldridge

1994-09-01T23:59:59.000Z

262

REBAL '92A Cooperative Radiation and Energy Balance Field Study for Imagery and Electromagnetic Propagation  

Science Conference Proceedings (OSTI)

The surface energy balance directly affects vertical gradients in temperature and specific humidity within the atmospheric surface layer, and these gradients influence optical turbulence. This study was conducted to improve current understanding ...

Arnold Tunick; Henry Rachele; Frank V. Hansen; Terry A. Howell; Jean L. Steiner; Ariand D. Schneider; Steve R. Evett

1994-03-01T23:59:59.000Z

263

Origins and consequences of radiation…induced centrosome aberrations  

NLE Websites -- All DOE Office Websites (Extended Search)

Origins and consequences of radiation-induced centrosome aberrations Origins and consequences of radiation-induced centrosome aberrations Sangeetha Vijayakumar, Nisarg Shah, Ignacio Fernandez-Garcia, Mary Helen Barcellos-Hoff Department of Radiation Oncology, New York University School of Medicine, NY, NY. Centrosome aberrations are frequently observed in pre-neoplastic breast lesions and are known to drive chromosomal instability (Lingle et al., 2002). Previous studies from our lab have shown that human mammary epithelial cells exposed to low doses of radiation exhibit centrosome aberrations (CAs) in a dose dependent manner from 10-200 cGy (Maxwell et al., 2008). These data demonstrated that radiation-induced CAs actually precede and generate genomic instability and that TGFβ is a key mediator

264

Low dose radiation combines with the Src oncoprotein to transform  

NLE Websites -- All DOE Office Websites (Extended Search)

radiation combines with the Src oncoprotein to transform radiation combines with the Src oncoprotein to transform pre-malignant human breast cells Paul Yaswen Lawrence Berkeley National Laboratory Abstract Goal: Determine whether low dose radiation exerts persistent epigenetic effects that promote malignancy. Background and Significance: Some persistent carcinogenic effects of radiation may not be traceable to specific DNA sequence alterations and may not be linearly related to dose. Through the biochemical initiation of positive feedback loops, ionization-induced events may have heritable non-linear effects on cellular behavior. Inflammatory responses involving the transcription factor NFκB may be subject to such effects. Increased NFκB activity has been strongly linked to carcinogenesis in a number of published in vitro and in vivo studies (reviewed in [1]). Since radiation

265

Low Dose Radiation Research Program: Multidimensional Analysis...  

NLE Websites -- All DOE Office Websites (Extended Search)

Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Berkeley, CA. (Jointly funded by...

266

Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence. http://pos.sissa.it Study of the radiation-hardness of VCSEL and PIN  

E-Print Network (OSTI)

. This provides a simple mechanism to recover from the radiation damage. 9th International Conference on Large the radiation exposure and simplify the detector construction. In fact, the electric signals from the front-NonCommercial-ShareAlike Licence. http://pos.sissa.it Study of the radiation-hardness of VCSEL and PIN K.K. Gan1 , W. Fernando, H

Gan, K. K.

267

Spatially and Temporally Resolved Studies of the Human Microbiome (2011 JGI User Meeting)  

Science Conference Proceedings (OSTI)

The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Rob Knight of the University of Colorado gives a presentation on "Spatially and Temporally Resolved Studies of the Human Microbiome" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

Knight, Rob [University of Colorado

2011-03-23T23:59:59.000Z

268

he Impact of Primary Marine Aerosol on Atmospheric Chemistry, Radiation and Climate: A CCSM Model Development Study  

SciTech Connect

This project examined the potential large-scale influence of marine aerosol cycling on atmospheric chemistry, physics and radiative transfer. Measurements indicate that the size-dependent generation of marine aerosols by wind waves at the ocean surface and the subsequent production and cycling of halogen-radicals are important but poorly constrained processes that influence climate regionally and globally. A reliable capacity to examine the role of marine aerosol in the global-scale atmospheric system requires that the important size-resolved chemical processes be treated explicitly. But the treatment of multiphase chemistry across the breadth of chemical scenarios encountered throughout the atmosphere is sensitive to the initial conditions and the precision of the solution method. This study examined this sensitivity, constrained it using high-resolution laboratory and field measurements, and deployed it in a coupled chemical-microphysical 3-D atmosphere model. First, laboratory measurements of fresh, unreacted marine aerosol were used to formulate a sea-state based marine aerosol source parameterization that captured the initial organic, inorganic, and physical conditions of the aerosol population. Second, a multiphase chemical mechanism, solved using the Max Planck Institute for Chemistry??s MECCA (Module Efficiently Calculating the Chemistry of the Atmosphere) system, was benchmarked across a broad set of observed chemical and physical conditions in the marine atmosphere. Using these results, the mechanism was systematically reduced to maximize computational speed. Finally, the mechanism was coupled to the 3-mode modal aerosol version of the NCAR Community Atmosphere Model (CAM v3.6.33). Decadal-scale simulations with CAM v.3.6.33, were run both with and without reactive-halogen chemistry and with and without explicit treatment of particulate organic carbon in the marine aerosol source function. Simulated results were interpreted (1) to evaluate influences of marine aerosol production on the microphysical properties of aerosol populations and clouds over the ocean and the corresponding direct and indirect effects on radiative transfer; (2) atmospheric burdens of reactive halogen species and their impacts on O3, NOx, OH, DMS, and particulate non-sea-salt SO42-; and (3) the global production and influences of marine-derived particulate organic carbon. The model reproduced major characteristics of the marine aerosol system and demonstrated the potential sensitivity of global, decadal-scale climate metrics to multiphase marine-derived components of Earth??s troposphere. Due to the combined computational burden of the coupled system, the currently available computational resources were the limiting factor preventing the adequate statistical analysis of the overall impact that multiphase chemistry might have on climate-scale radiative transfer and climate.

Keene, William C. [University of Virginia] [University of Virginia; Long, Michael S. [University of Virginia] [University of Virginia

2013-05-20T23:59:59.000Z

269

A Phase I Study of Short-Course Accelerated Whole Brain Radiation Therapy for Multiple Brain Metastases  

SciTech Connect

Purpose: To define the maximum tolerated dose (MTD) of a SHort-course Accelerated whole brain RadiatiON therapy (SHARON) in the treatment of patients with multiple brain metastases. Methods and Materials: A phase 1 trial in 4 dose-escalation steps was designed: 12 Gy (3 Gy per fraction), 14 Gy (3.5 Gy per fraction), 16 Gy (4 Gy per fraction), and 18 Gy (4.5 Gy per fraction). Eligibility criteria included patients with unfavorable recursive partitioning analysis (RPA) class > or =2 with at least 3 brain metastases or metastatic disease in more than 3 organ systems, and Eastern Cooperative Oncology Group (ECOG) performance status {<=}3. Treatment was delivered in 2 days with twice-daily fractionation. Patients were treated in cohorts of 6-12 to define the MTD. The dose-limiting toxicity (DLT) was defined as any acute toxicity {>=}grade 3, according to the Radiation Therapy Oncology Group scale. Information on the status of the main neurologic symptoms and quality of life were recorded. Results: Characteristics of the 49 enrolled patients were as follows: male/female, 30/19; median age, 66 years (range, 23-83 years). ECOG performance status was <3 in 46 patients (94%). Fourteen patients (29%) were considered to be in recursive partitioning analysis (RPA) class 3. Grade 1-2 acute neurologic (26.4%) and skin (18.3%) toxicities were recorded. Only 1 patient experienced DLT (neurologic grade 3 acute toxicity). With a median follow-up time of 5 months (range, 1-23 months), no late toxicities have been observed. Three weeks after treatment, 16 of 21 symptomatic patients showed an improvement or resolution of presenting symptoms (overall symptom response rate, 76.2%; confidence interval 0.95: 60.3-95.9%). Conclusions: Short-course accelerated radiation therapy in twice-daily fractions for 2 consecutive days is tolerated up to a total dose of 18 Gy. A phase 2 study has been planned to evaluate the efficacy on overall survival, symptom control, and quality of life indices.

Caravatta, Luciana; Deodato, Francesco; Ferro, Marica [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Macchia, Gabriella, E-mail: gmacchia@rm.unicatt.it [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Massaccesi, Mariangela [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Radiation Oncology, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Cilla, Savino [Medical Physics Unit, Fondazione di Ricerca e Cura 'Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy)] [Medical Physics Unit, Fondazione di Ricerca e Cura 'Giovanni Paolo II,' Universita Cattolica del S. Cuore, Campobasso (Italy); Padula, Gilbert D.A. [Department of Radiation Oncology, The Lacks Cancer Center Saint Mary's Health Care, Grand Rapids, Michigan (United States)] [Department of Radiation Oncology, The Lacks Cancer Center Saint Mary's Health Care, Grand Rapids, Michigan (United States); Mignogna, Samantha; Tambaro, Rosa [Department of Palliative Therapies, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy)] [Department of Palliative Therapies, Fondazione di Ricerca e Cura 'Giovanni Paolo II', Universita Cattolica del S. Cuore, Campobasso (Italy); Carrozza, Francesco [Department of Oncology, A. Cardarelli Hospital, Campobasso (Italy)] [Department of Oncology, A. Cardarelli Hospital, Campobasso (Italy); Flocco, Mariano [Madre Teresa di Calcutta Hospice, Larino (Italy)] [Madre Teresa di Calcutta Hospice, Larino (Italy); Cantore, Giampaolo [Department of Neurological Sciences, Istituto Neurologico Mediterraneo Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli (Italy)] [Department of Neurological Sciences, Istituto Neurologico Mediterraneo Neuromed, Istituto di Ricovero e Cura a Carattere Scientifico, Pozzilli (Italy); Scapati, Andrea [Department of Radiation Oncology, 'San Francesco' Hospital, Nuoro (Italy)] [Department of Radiation Oncology, 'San Francesco' Hospital, Nuoro (Italy); Buwenge, Milly [Department of Radiotherapy, Mulago Hospital, Kampala (Uganda)] [Department of Radiotherapy, Mulago Hospital, Kampala (Uganda); and others

2012-11-15T23:59:59.000Z

270

Office of International Health Studies  

NLE Websites -- All DOE Office Websites (Extended Search)

International Health Studies International Health Studies Home Mission and Functions Japan Radiation Effects Research Foundation (RERF) Studies Marshall Islands Program Russian Health Studies Program Russian Radiobiology Human Tissue Repository Spain (Palomares) Program Health and Safety HSS Logo Office of International Health Studies Reports to the Office of Health and Safety Mission and Functions Mission The Office of International Health Studies engages in the conduct of international scientific studies that may provide new knowledge and information about the human response to ionizing radiation in the workplace or people exposed in communities as a result of nuclear accidents. The mission includes providing health and environmental monitoring services to populations specified by law.

271

Optical Radiation  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Optical Radiation Measurements. Fees for services are located directly below the technical contacts ...

2013-04-09T23:59:59.000Z

272

Ionizing Radiation  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Ionizing Radiation Measurements. Fees for services are located directly below the technical contacts ...

2013-04-09T23:59:59.000Z

273

Low Dose Radiation Program: Links - Agencies with Radiation Regulatory  

NLE Websites -- All DOE Office Websites (Extended Search)

Agencies with Radiation Regulatory Concerns and Involvement Agencies with Radiation Regulatory Concerns and Involvement Biological Effects of Low Level Exposures (BELLE) Canadian Nuclear Safety Commission Center for Risk Excellence Health Protection Agency The Health Risks of Extraterrestrial Environments International Commission on Radiation Units and Measurements, Inc. International Commission on Radiological Protection (ICRP) International Radiation Protection Association (IRPA) NASA Space Radiation Program National Academy of Sciences (NAS) Nuclear and Radiation Studies Board National Aeronautics and Space Administration (NASA) NASA OBRR Task Book Publication National Council on Radiation Protection (NCRP) National Institute of Environmental Health Sciences (NIEHS) National Toxicology Program (NTP) Occupational Safety and Health Administration (OSHA)

274

Carbon contamination and oxidation of Au surfaces under extreme ultraviolet radiation: An x-ray photoelectron spectroscopy study  

E-Print Network (OSTI)

Carbon contamination and oxidation of Au surfaces under extreme ultraviolet radiation: An x 2012) Extreme ultraviolet (EUV) radiation-induced carbon contamination and oxidation of Au surfaces modification during EUV exposure. XPS analysis showed that total carbon contamination (C 1s peak

Harilal, S. S.

275

Effects of atomic radiation: A half-century of studies from Hiroshima and Nagasaki  

SciTech Connect

This is a notable book. For the first time, a thoroughly experienced scientist has undertaken, as the author says, {open_quotes}to present the atomic bomb survivor story in all its complexity,{close_quotes} and to aid the reader, Prof. Schull has eschewed the use of technical terms. Where this could not be done, he has defined them in the text or the glossary. The task could only have been done by someone like Prof. Schull, who in various capacities has been involved in the Japanese studies since 1949. The book therefore is not a conventional epidemiological monograph. It is addressed to both the professional and nonprofessional reader, and it includes various elements of biology; it deals with history as well as science; and it considers some of its material as in a personal essay. This is an ambitious, difficult and useful undertaking that provides much information; its writing, however, is not always quite direct and incisive.

Schull, W.J.

1996-11-01T23:59:59.000Z

276

Study of e+e- --> p anti-p via initial-state radiation at BABAR  

E-Print Network (OSTI)

The process e+e- --> p anti-p gamma is studied using 469 fb-1 of integrated luminosity collected with the BABAR detector at the PEP-II collider, at an e+e- center-of-mass energy of 10.6 GeV. From the analysis of the p anti-p invariant mass spectrum, the energy dependence of the cross section for e+e- --> p anti-p is measured from threshold to 4.5 GeV. The energy dependence of the ratio of electric and magnetic form factors, |G_E/G_M|, and the asymmetry in the proton angular distribution are measured for p anti-p masses below 3 GeV. We also measure the branching fractions for the decays J/psi --> p anti-p and psi(2S) --> p anti p.

The BABAR Collaboration

2013-02-01T23:59:59.000Z

277

Study of radiative blast waves generated on the Z-beamlet laser.  

Science Conference Proceedings (OSTI)

This document describes the original goals of the project to study the Vishniac Overstability on blast waves produced using the Z-Beamlet laser facility as well as the actual results. The proposed work was to build on earlier work on the facility and result in the best characterized set of data for such phenomena in the laboratory. To accomplish the goals it was necessary to modify the existing probe laser at the facility so that it could take multiple images over the course of 1-2 microseconds. Troubles with modifying the probe laser are detailed as well as the work that went into said modifications. The probe laser modification ended up taking the entire length of the project and were the major accomplishment of the research.

Edens, Aaron D.; Schwarz, Jens

2012-02-01T23:59:59.000Z

278

Preliminary Analysis of Surface Radiation Measurement Data Quality...  

NLE Websites -- All DOE Office Websites (Extended Search)

primary radiation flux measurements at the SGP extended facilities are obtained from the Solar Infrared Radiation Station (SIRS). In this study, we examine the radiation...

279

A novel approach in electron beam radiation therapy of lips carcinoma: A Monte Carlo study  

SciTech Connect

Purpose: Squamous cell carcinoma (SCC) is commonly treated by electron beam radiotherapy (EBRT) followed by a boost via brachytherapy. Considering the limitations associated with brachytherapy, in this study, a novel boosting technique in EBRT of lip carcinoma using an internal shield as an internal dose enhancer tool (IDET) was evaluated. An IDET is referred to a partially covered internal shield located behind the lip. It was intended to show that while the backscattered electrons are absorbed in the portion covered with a low atomic number material, they will enhance the target dose in the uncovered area. Methods: Monte-Carlo models of 6 and 8 MeV electron beams were developed using BEAMnrc code and were validated against experimental measurements. Using the developed models, dose distributions in a lip phantom were calculated and the effect of an IDET on target dose enhancement was evaluated. Typical lip thicknesses of 1.5 and 2.0 cm were considered. A 5 Multiplication-Sign 5 cm{sup 2} of lead covered by 0.5 cm of polystyrene was used as an internal shield, while a 4 Multiplication-Sign 4 cm{sup 2} uncovered area of the shield was used as the dose enhancer. Results: Using the IDET, the maximum dose enhancement as a percentage of dose at d{sub max} of the unshielded field was 157.6% and 136.1% for 6 and 8 MeV beams, respectively. The best outcome was achieved for lip thickness of 1.5 cm and target thickness of less than 0.8 cm. For lateral dose coverage of planning target volume, the 80% isodose curve at the lip-IDET interface showed a 1.2 cm expansion, compared to the unshielded field. Conclusions: This study showed that a boost concomitant EBRT of lip is possible by modifying an internal shield into an IDET. This boosting method is especially applicable to cases in which brachytherapy faces limitations, such as small thicknesses of lips and targets located at the buccal surface of the lip.

Shokrani, Parvaneh [Medical Physics and Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); Baradaran-Ghahfarokhi, Milad [Medical Physics and Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran and Medical Radiation Engineering Department, Faculty of Advanced Sciences and Technologies, Isfahan University, Isfahan 81746-73441 (Iran, Islamic Republic of); Zadeh, Maryam Khorami [Medical Physics Department, School of Medicine, Ahwaz Jundishapour University of Medical Sciences, Ahwaz 15794-61357 (Iran, Islamic Republic of)

2013-04-15T23:59:59.000Z

280

About Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Radiation What is radiation? Radiation is a form of energy that is a part of our everyday lives. All of us receive a "dose" of radiation each day. Most of the dose comes from naturally occurring radioactive materials such as uranium, thorium, radon, and certain forms of potassium and carbon. The air we breathe contains radon, the food we eat contains uranium and thorium from the soil, and our bodies contain radioactive forms of potassium and carbon. Cosmic radiation from the sun also contributes to our natural radiation dose. We also receive radiation doses from man-made sources such as X-rays, nuclear medical procedures, power plants, smoke detectors and older television sets. Some people, such as nuclear plant operators, flight crews, and nuclear medicine staff may also receive an occupational radiation dose.

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Low Dose Radiation Research Program: Mary Helen Barcellos-Hoff - 2003  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE Low Dose Radiation Program Workshop IV DOE Low Dose Radiation Program Workshop IV Abstract Title: TGF-β Protects Human Mammary Epithelial Cells from Radiation-Induced Centrosome Amplification Authors: Mary Helen Barcellos-Hoff, Bahram Parvin, Anna C. Erickson and Rishi Gupta Institutions: Department of Cell and Molecular Biology, Life Sciences Division, Ernest Orlando Lawrence, Berkeley National Laboratory, Berkeley, California In recent studies we have shown that ionizing radiation (IR), a known carcinogen of human and murine mammary gland, compromises human mammary epithelial cell (HMEC) polarity and multicellular organization in a manner characteristic of neoplastic progression through a heritable, non-mutational mechanism (1). Thus, when all cells are irradiated with a significant dose (2 Gy), the daughters of irradiated cells lose their

282

Low Dose Radiation Research Program: Multi-cellular Crosstalk in Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

About this Project About this Project Multi-cellular Crosstalk in Radiation Damage Technical Abstracts 2006 Workshop: Low-LET Bystander Effects in Cells In Vitro Are Significantly Less Than Published For High-LET Radiation Blakely, E.A., Thompson, A.C., Chang, P., Schwarz, R.I., Bjornstad, K., Rosen, C., Wisnewski, C., and Mocherla, D. 2005 Workshop: X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., Sudar, D., Romano, R., and Parvin, B. 2003 Workshop: 12.5 keV X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., and Sudar, D. 2001 Workshop:

283

Radiation Physics Portal  

Science Conference Proceedings (OSTI)

NIST Home > Radiation Physics Portal. Radiation Physics Portal. ... more. >> see all Radiation Physics programs and projects ... ...

2013-08-08T23:59:59.000Z

284

Structural and Functional Studies on Human Mitochondrial Iron-Sulfur Cluster Biosynthesis  

E-Print Network (OSTI)

Iron-sulfur (Fe-S) clusters are critical protein cofactors found in all life forms. In eukaryotes, a well-conserved biosynthetic pathway located in the mitochondria is used to assemble Fe-S clusters. Although proteins required for Fe-S cluster biosynthesis have been identified, their precise function and mechanism remain elusive. In this study, biochemical and biophysical methods are applied to understand molecular details for the core components of the human Fe-S cluster biosynthesis: Nfs1, Isd11, Isu2, and frataxin (Fxn). Nfs1 is a cysteine desulfurase that converts cysteine into alanine and transfers the sulfur to a scaffold protein Isu2 for Fe-S clusters. Fxn depletion is associated with the neurodegenerative disease Friedreichs ataxia (FRDA), and results in a complicated phenotype that includes loss of Fe-S clusters. The results presented here provide the first in vitro evidence for a stable protein complex that exists in at least two forms: an inactive complex with Nfs1, Isd11, and Isu2 (SDU) components and an active form that also includes Fxn (SDUF). Fxn binding dramatically changes the catalytic efficiency (kcat/KM) of Nfs1 from 25 to 10,100 M-1s-1 and enhances the rate of Fe-S cluster biosynthesis 25 fold. Oxidizing conditions diminish the levels of both complex formation and Fxn-based activation, whereas Fe2 further stimulates Nfs1 activity. Mutagenesis coupled to enzyme kinetics indicate that one of the three conserved cysteines (C104) on Isu2 accepts the sulfane sulfur from Nfs1 and that this transfer event likely requires prior binding of Fxn. In vitro interrogation of FRDA I154F and W155R and related Fxn variants revealed the binding affinity to SDU followed the trend Fxn ~ I154F > W155F > W155A ~ W155R. The Fxn variants also have diminished ability to facilitate both sulfur transfer and Fe-S cluster assembly. Fxn crystallographic structures reveal specific rearrangements associated with the loss of function. Importantly, the weaker binding and lower activity of the W155R variant compared to I154F explains the earlier onset and more severe disease progression. Finally, these experimental results coupled with computational docking studies suggest a model for how human Fxn functions as an allosteric activator and triggers sulfur transfer and Fe-S cluster assembly.

Tsai, Chi-Lin

2011-05-01T23:59:59.000Z

285

Solar radiation model validation  

Science Conference Proceedings (OSTI)

Several mathematical models have been developed within the past few years which estimate the solar radiation from other weather variables. Some of these models have been used to generate data bases which are extensively used in the design and analysis of solar system. Three of these solar radiation models have been used in developing the Augmented SOLMET Solar Data Tapes for the 26 SOLMET sites and the 222 ERSATZ Solar Data Tapes. One of the models, a theoretical one, predicts the solar noon radiation for clear sky conditions from the optical air mass, precipitable water vapor and turbidity variables. A second model, an empirical one, predicts the hourly total horizontal radiation from meteorological variables. And, a third model, also an empirical one, predicts the hourly direct normal radiation from the hourly total horizontal radiation. A study of the accuracy of these three solar radiation models is reported here. To assess the accuracy of these models, data were obtained from several US National Weather Service Stations and other sources, used the models to estimate the solar-radiation, and then compared the modeled radiation values with observed radiation values. The results of these comparisons and conclusions regarding the accuracy of the models are presented.

Hall, I.J.; Prairie, R.R.; Anderson, H.E.; Boes, E.C.

1980-10-01T23:59:59.000Z

286

Remote Sensing of Cirrus Radiative Parameters during EUCREX94. Case Study of 17 April 1994. Part I: Observations  

Science Conference Proceedings (OSTI)

During the intensive European Cloud and Radiation Experiment 1994 (EUCREX94) conducted off the coast of Brittany (France) over the Atlantic Ocean during April 1994, natural cirrus have been analyzed from in situ and remote sensing measurements. ...

Laurent Sauvage; Pierre H. Flamant; Hlne Chepfer; Grard Brogniez; Vincent Trouillet; Jacques Pelon; Franck Albers

1999-04-01T23:59:59.000Z

287

Study of the radiative decays ? ?f0(980)? and ? ?a0(980)? with the KLOE detector  

Science Conference Proceedings (OSTI)

The KLOE experiment at the electron?positron collider DAPHNE has collected in the 20012002 running period an integrated luminosity of 450 pb?1. Through the radiative ? decays

The KLOE collaboration; C. Bini

2006-01-01T23:59:59.000Z

288

Microphysical and Radiative Effects of Ice Clouds on Tropical Equilibrium States: A Two-Dimensional Cloud-Resolving Modeling Study  

Science Conference Proceedings (OSTI)

The microphysical and radiative effects of ice clouds on tropical equilibrium states are investigated based on three two-dimensional cloud-resolving simulations imposed by zero vertical velocity and time-invariant zonal wind and sea surface ...

Fan Ping; Zhexian Luo; Xiaofan Li

2007-07-01T23:59:59.000Z

289

Improvements in the Shortwave Cloud-free Radiation Budget Accuracy. Part I: Numerical Study Including Surface Anisotropy  

Science Conference Proceedings (OSTI)

The shortwave radiation field, i.e., in the solar spectral range, emerging at the top of the atmosphere is anisotropic due to the optical properties of the atmosphere and the reflectance characteristics of the underlying surface. Thus, anisotropy ...

P. Koepke; K. T. Kriebel

1987-03-01T23:59:59.000Z

290

Low Dose Radiation Research Program: Low Dose Radiation Effects in  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Effects in Differentiating Human Lens Cells Radiation Effects in Differentiating Human Lens Cells E.A. Blakely1, M.P. McNamara1, P.Y. Chang1, K.A. Bjornstad1, D. Sudar1, and A.C. Thompson2 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California; 2Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California. Introduction The human lens is one of the most radiosensitive organs of the body. Cataract, the opacification of the lens, is a late-appearing response to radiation damage. There are few data available on the late radiation effects of exposure in space flight to charged particle beams, the most prevalent of which are protons. Basic research in this area is needed to integrate the responses of both critical and other representative tissues

291

Radiation Cataract  

NLE Websites -- All DOE Office Websites (Extended Search)

radiation including patients undergoing diagnostic CT scans or radiotherapy, atomic bomb survivors, residents of radioactively contaminated buildings, victims of the...

292

Three-Year Outcomes of a Canadian Multicenter Study of Accelerated Partial Breast Irradiation Using Conformal Radiation Therapy  

SciTech Connect

Purpose: To report 3-year toxicity, cosmesis, and efficacy of a multicenter study of external beam, accelerated partial breast irradiation (APBI) for early-stage breast cancer. Methods and Materials: Between March 2005 and August 2006, 127 women aged {>=}40 years with ductal carcinoma in situ or node-negative invasive breast cancer {<=}3 cm in diameter, treated with breast-conserving surgery achieving negative margins, were accrued to a prospective study involving five Canadian cancer centers. Women meeting predefined dose constraints were treated with APBI using 3 to 5 photon beams, delivering 35 to 38.5 Gy in 10 fractions, twice a day, over 1 week. Patients were assessed for treatment-related toxicities, cosmesis, and efficacy before APBI and at specified time points for as long as 3 years after APBI. Results: 104 women had planning computed tomography scans showing visible seromas, met dosimetric constraints, and were treated with APBI to doses of 35 Gy (n = 9), 36 Gy (n = 33), or 38.5 Gy (n = 62). Eighty-seven patients were evaluated with minimum 3-year follow-up after APBI. Radiation dermatitis, breast edema, breast induration, and fatigue decreased from baseline levels or stabilized by the 3-year follow-up. Hypopigmentation, hyperpigmentation, breast pain, and telangiectasia slightly increased from baseline levels. Most toxicities at 3 years were Grade 1. Only 1 patient had a Grade 3 toxicity with telangiectasia in a skin fold inside the 95% isodose. Cosmesis was good to excellent in 86% (89/104) of women at baseline and 82% (70/85) at 3 years. The 3-year disease-free survival was 97%, with only one local recurrence that occurred in a different quadrant away from the treated site and two distant recurrences. Conclusions: At 3 years, toxicity and cosmesis were acceptable, and local control and disease-free survival were excellent, supporting continued accrual to randomized APBI trials.

Berrang, Tanya S., E-mail: tberrang@bccancer.bc.ca [British Columbia Cancer Agency-Vancouver Island, BC (Canada); University of British Columbia, BC (Canada); Olivotto, Ivo [British Columbia Cancer Agency-Vancouver Island, BC (Canada); University of British Columbia, BC (Canada); Kim, Do-Hoon [Juravinski Cancer Centre, Ontario (Canada); McMaster University, Ontario (Canada); Nichol, Alan [British Columbia Cancer Agency-Vancouver Centre, BC (Canada); University of British Columbia, BC (Canada); Cho, B.C. John [Princess Margaret Hospital, Ontario (Canada); University of Toronto, Ontario (Canada); Mohamed, Islam G. [British Columbia Cancer Agency-Southern Interior, BC (Canada); University of British Columbia, BC (Canada); Parhar, Tarnjit [British Columbia Cancer Agency-Vancouver Centre, BC (Canada); University of British Columbia, BC (Canada); Wright, J.R. [Juravinski Cancer Centre, Ontario (Canada); McMaster University, Ontario (Canada); Truong, Pauline [British Columbia Cancer Agency-Vancouver Island, BC (Canada); University of British Columbia, BC (Canada); Tyldesley, Scott [British Columbia Cancer Agency-Vancouver Centre, BC (Canada); University of British Columbia, BC (Canada); Sussman, Jonathan [Juravinski Cancer Centre, Ontario (Canada); McMaster University, Ontario (Canada); Wai, Elaine [British Columbia Cancer Agency-Vancouver Island, BC (Canada); University of British Columbia, BC (Canada); Whelan, Tim [Juravinski Cancer Centre, Ontario (Canada); McMaster University, Ontario (Canada)

2011-12-01T23:59:59.000Z

293

Multiscale non-adiabatic dynamics with radiative decay, case study on the post-ionization fragmentation of rare-gas tetramers  

E-Print Network (OSTI)

In this supplementary material, we recollect, for reader's convenience, the general scheme of suggested multiscale model (Sec. 1), and basic informations about approaches used for pilot study: a detailed description of the interaction model (Sec. 2) and dynamical methods used for the dark dynamics step (Sec. 3) reported previously in two preceding studies [1, 2]. In addition, a detailed description of the treatment of radiative processes is also given (Sec. 4).

Jane?ek, Ivan; Naar, Pavel; Renard, Frederic; Kalus, Ren; Gada, Florent X

2012-01-01T23:59:59.000Z

294

Do heavy ions induce the bystander effect? : study to determine the induction of the bystander effect from Fe ion beam compared to X-rays in human keratinocytes  

E-Print Network (OSTI)

The bystander effect is the observation that non-irradiated cells near a cell traversed by radiation express biological responses such as micronuclei formation and genomic instability. Most published studies of the bystander ...

Anzenberg, Vered

2005-01-01T23:59:59.000Z

295

Study of the interaction of C60 fullerene with human serum albumin in aqueous solution  

Science Conference Proceedings (OSTI)

Concern about the toxicity of engineered nanoparticles, such as the prototypical nanomaterial C60 fullerene, continues to grow. While evidence continues to mount that C60 and its derivatives may pose health hazards, the specific molecular interactions of these particles with biological macromolecules require further investigation. To better understand the interaction of C60 with proteins, the protein human serum albumin (HSA) was studied in solution with C60 at C60:HSA molar ratios ranging from 1:2 to 4:1. HSA is the major protein component of blood plasma and plays a role in a variety of functions, such as the maintenance of blood pH and pressure. The C60-HSA interaction was probed by a combination of circular dichroism (CD) spectroscopy, small-angle neutron scattering (SANS) and atomistic molecular dynamics (MD) simulations to understand C60-driven changes in the structure of HSA in solution. The CD spectroscopy demonstrates that the secondary structure of the protein decreases in -helical content in response to the presence of C60. Similarly, C60 produces subtle changes in the solution conformation of HSA, as evidenced by the SANS data and MD. The data do not indicate that C60 is causing a change in the oligomerization state of the protein. Taken together results demonstrate that C60 interacts with HSA, but it does not strongly perturb the structure of the protein by unfolding it or inducing aggregation, suggesting a mechanism for transporting C60 throughout the body to accumulate in various tissues.

Li, Song [Vanderbilt University; Zhao, Xiongce [National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Mo, Yiming [ORNL; Cummings, Peter T [ORNL; Heller, William T [ORNL

2013-01-01T23:59:59.000Z

296

Low Dose Radiation Research Program: Image Gallery  

NLE Websites -- All DOE Office Websites (Extended Search)

Image Gallery Image Gallery These are images, photographs, and charts presented or developed for Low Dose Radiation Research Investigators’ Meetings. They may be used for presentations or reports. To save, right click on the picture, then choose "Save picture as." U.S. annual per-capita effective radiation dose from various sources for 1980. various sources 1980 Enlarge Image. U.S. annual per-capita effective radiation dose from various sources for 2006. various sources 2006 Enlarge Image. U.S. annual per-capita effective radiation dose from man-made sources in the United States for 2006. man-made 2006 Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience (Rem) Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience

297

An adaptive approach to metal artifact reduction in helical computed tomography for radiation therapy treatment planning: Experimental and clinical studies  

SciTech Connect

Purpose: In this article, an approach to metal artifact reduction is proposed that is practical for clinical use in radiation therapy. It is based on a new interpolation scheme of the projections associated with metal implants in helical computed tomography (CT) scanners. Methods and Materials: A three-step approach was developed consisting of an automatic algorithm for metal implant detection, a correction algorithm for helical projections, and a new, efficient algorithm for projection interpolation. The modified raw projection data are transferred back to the CT scanner device where CT slices are regenerated using the built-in reconstruction operator. The algorithm was tested on a CT calibration phantom in which the density of inserted objects are known and on clinical prostate cases with two hip prostheses. The results are evaluated using the CT number and shape of the objects. Results: The validations on a CT calibration phantom with various inserts of known densities show that the algorithm improved the overall image quality by restoring the shape and the representative CT number of the objects in the image. For the clinical hip replacement cases, a large fraction of the bladder, rectum, and prostate that were not visible on the original CT slices were recovered using the algorithm. Precise contouring of the target volume was thus feasible. Without this enhancement, physicians would have drawn bigger margins to be sure to include the target and, at the same time, could have prescribed a lower dose to keep the same level of normal tissue toxicity. Conclusions: In both phantom experiment and patient studies, the algorithm resulted in significant artifact reduction with increases in the reliability of planning procedure for the case of metallic hip prostheses. This algorithm is now clinically used as a preprocessing before treatment planning for metal artifact reduction.

Yazdia, Mehran [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada); Gingras, Luc [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada); Departement de Physique, Genie Physique et d' Optique, Universite Laval, Quebec City, Quebec (Canada); Beaulieu, Luc [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada) and Departement de Physique, Genie Physique et d' Optique, Universite Laval, Quebec City, Quebec (Canada)]. E-mail: beaulieu@phy.ulaval.ca

2005-07-15T23:59:59.000Z

298

DOE Order Self Study Modules - DOE O 458.1, Radiation Protection of the Public and the Environment  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

58.1 58.1 RADIATION PROTECTION OF THE PUBLIC AND THE ENVIRONMENT DOE O 458.1 Familiar Level August 2011 1 DOE O 458.1 RADIATION PROTECTION OF THE PUBLIC AND THE ENVIRONMENT FAMILIAR LEVEL OBJECTIVES Given the familiar level of this module and the resources listed below, you will be able to answer the following questions: 1. What are the objectives of DOE O 458.1? 2. What are the definitions for the following terms?  Residual radioactive material  Public dose  ALARA  Soil column ( in the context of radiation protection of the environment) 3. What are three basic considerations that should be observed in an ALARA process for DOE radioactive activities? 4. What are four elements that must be included in dose evaluations to demonstrate

299

Low Dose Radiation Research Program: Marianne B. Sowa  

NLE Websites -- All DOE Office Websites (Extended Search)

Marianne B. Sowa Marianne B. Sowa PNNL - Pacific Northwest National Laboratory Funded Projects A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Morphological Changes in a 3D Mammary Model Following Exposure to Low Dose, Low-LET Radiation Opresko, L.K., Chrisler, W., Emory, K., Arthurs, B., and Sowa, M.B. 2005 Workshops: Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Morgan, W.F. and Sowa, M.B. Publications Perrine, K.A., Lamarche, B.L., Hopkins, D.F., Budge, S.E., Opresko, L.K., Wiley, H.S., and Sowa, M.B. (2007). High speed method for in situ

300

Biological Basis for Radiation Adaptive Responses that Protect Against  

NLE Websites -- All DOE Office Websites (Extended Search)

Basis for Radiation Adaptive Responses that Protect Against Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen Lovelace Respiratory Research Institute Abstract The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer method were used to study the mechanisms of low-LET gamma radiation activated natural protection (ANP) against chemical carcinogen-induced bronchial cell transformation. Immortalized human bronchial epithelial cell

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Radiation Safety  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Brotherhood of Locomotive Brotherhood of Locomotive Engineers & Trainmen Scott Palmer BLET Radiation Safety Officer New Hire Training New Hire study topics * GCOR * ABTH * SSI * Employee Safety * HazMat * Railroad terminology * OJT * 15-week class * Final test Hazardous Materials * Initial new-hire training * Required by OSHA * No specified class length * Open book test * Triennial module Locomotive Engineer Training A little bit older...a little bit wiser... * Typically 2-4 years' seniority * Pass-or-get-fired promotion * Intensive program * Perpetually tested to a higher standard * 20 Weeks of training * 15 of that is OJT * General Code of Operating Rules * Air Brake & Train Handling * System Special Instructions * Safety Instructions * Federal Regulations * Locomotive Simulators * Test Ride * Pass test with 90% Engineer Recertification

302

Parameterizations for the Absorption of Solar Radiation by O2 and CO2 with Application to Climate Studies  

Science Conference Proceedings (OSTI)

Simple and accurate parameterizations have been developed for computing the absorption of solar radiation due to O2 and CO2. The parameterizations are based on the findings that temperature has a minimal effect on the absorption and that the one-...

Ming-Dah Chou

1990-02-01T23:59:59.000Z

303

Synchrotron radiation x-ray absorption fine-structure and Raman studies on CdZnTe ternary alloys  

E-Print Network (OSTI)

The synchrotron radiation (SR) X-ray absorption fine-structure spectroscopy (XAFS) technology has been employed to obtained Zn K-edge absorption spectra for Cd1[subscript 1-x]Zn[subscript x]Te alloy with x = 0.03, 0.10, ...

Becla, Piotr

304

Understanding human values in adopting new technology-A case study and methodological discussion  

Science Conference Proceedings (OSTI)

This paper proposes a method for understanding and modelling human values in the evaluation of new technology in social settings, and analyses the validity of the proposed method in a specific use case. The method, which is based on the Schwartz universal ... Keywords: Evaluation methods, School attendance control, Schwartz's value model, User experience evaluation, Value based design

Minna Isomursu; Mari Ervasti; Marianne Kinnula; Pekka Isomursu

2011-04-01T23:59:59.000Z

305

Review: Receptor-oriented approaches in wildlife and human exposure modelling: A comparative study  

Science Conference Proceedings (OSTI)

Five human and five wildlife receptor-oriented exposure models were compared with the aim to identify similarities, differences and areas where both fields can learn from each other. Similarities were revealed in exposure endpoints, chemical stressors ... Keywords: Chemical stressors, Contaminant exposure, Environmental risk assessment, Model comparison, Multiple stressors

Mark Loos; Aafke M. Schipper; Uwe Schlink; Kathrin Strebel; Ad M. J. Ragas

2010-04-01T23:59:59.000Z

306

10 http //www.kyoto-u.ac.jp/en. Integrated Human Studies  

E-Print Network (OSTI)

of Education Bachelor of Education Educational Sciences Faculty of Law Bachelor of Laws Faculty of Economics Bachelor of Economics Economics, Business Administration Faculty of Science Bachelor of Science Science Faculty of Medicine Bachelor of Medicine Medical Science(6-year program) Bachelor of Human Health Sciences

Takada, Shoji

307

Flow cytometric applications of tumor biology: prospects and pitfalls. [Applications in study of spontaneous dog tumors and in drug and radiation effects on cultured V79 cells  

SciTech Connect

A brief review of cytometry instrumentation and its potential applications in tumor biology is presented using our recent data. Age-distribution measurements of cells from spontaneous dog tumors and cultured cells after exposure to x rays, alpha particles, or adriamycin are shown. The data show that DNA fluorescence measurements have application in the study of cell kinetics after either radiation or drug treatment. Extensive and careful experimentation is needed to utilize the sophisticated developments in flow cytometry instrumentation.

Raju, M.R.; Johnson, T.S.; Tokita, N.; Gillette, E.L.

1979-01-01T23:59:59.000Z

308

Radiation Information  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Information << Timeline >> Content on this page requires a newer version of Adobe Flash Player. Get Adobe Flash player July 31, 1942 The Army Corp of Engineers leases...

309

Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B1 pharmacokinetics in human volunteers: A pilot study  

SciTech Connect

Chlorophyll (Chla) and chlorophyllin (CHL) were shown previously to reduce carcinogen bioavailability, biomarker damage, and tumorigenicity in trout and rats. These findings were partially extended to humans (Proc Natl Acad Sci USA 98, 14601-14606 (2001)), where CHL reduced excretion of aflatoxin B{sub 1} (AFB{sub 1})-DNA repair products in Chinese unavoidably exposed to dietary AFB{sub 1}. However, neither AFB{sub 1} pharmacokinetics nor Chla effects were examined. We conducted a small unblinded crossover study to establish AFB{sub 1} pharmacokinetic parameters in human volunteers, and to explore possible effects of CHL or Chla co-treatment on those parameters. For protocol 1, fasted subjects received an IRB-approved dose of 14C-AFB{sub 1} (30 ng, 5 nCi) by capsule with 100 ml water, followed by normal eating and drinking after hr 2. Blood and cumulative urine samples were collected over 72 hr, and {sup 14}C-AFB{sub 1} equivalents were determined by Accelerator Mass Spectrometry. Protocols 2 and 3 were similar except capsules also contained 150 mg of purified Chla, or CHL, respectively. All protocols were repeated 3 times for each of three volunteers. The study revealed rapid human AFB{sub 1} uptake (plasma ka 5.05 {+-} 1.10 hr-1, Tmax 1.0 hr) and urinary elimination (95% complete by 24 hr) kinetics. Chla and CHL treatment each significantly impeded AFB{sub 1} absorption and reduced Cmax and AUC's (plasma and urine) in one or more subjects. These initial results provide AFB{sub 1} pharmacokinetic parameters previously unavailable for humans, and suggest that Chla or CHL co-consumption may limit the bioavailability of ingested aflatoxin in humans, as they do in animal models.

Jubert, C; Mata, J; Bench, G; Dashwood, R; Pereira, C; Tracewell, W; Turteltaub, K; Williams, D; Bailey, G

2009-04-20T23:59:59.000Z

310

Applications of carbon-13 and sodium-23 NMR in the study of plants, animal, and human cells  

SciTech Connect

Carbon-13 and sodium-23 NMR have been applied to the study of a variety of plant, animal and human cell types. Sodium NMR, in combination with dysprosium shift reagents, has been used to monitor sodium transport kinetics in salt-adapted, and non-adapted cells of P. milliaceum and whole D. spicata plants. The sodium content of human erythrocytes and leukemic macrophages was measured. Carbon-13 NMR was used to determine the structure and metabolism of rat epididymal fat pad adipocytes in real time. Insulin and isoproterenol-stimulated triacylglycerol turnover could be monitored in fat cell suspensions. (1-/sup 13/C) glucose was used as a substrate to demonstrate futile metabolic cycling from glucose to glycerol during lypolysis. Cell wall polysaccharide synthesis was followed in suspensions of P. milliaceum cells using (1-/sup 13/C) glucose as a precursor. These results illustrate the wide range of living systems which are amenable to study with NMR. 14 refs., 21 figs.

Sillerud, L.O.; Heyser, J.W.; Han, C.H.; Bitensky, M.W.

1984-01-01T23:59:59.000Z

311

An Earth Outgoing Longwave Radiation Climate Model. Part II: Radiation with Clouds Included  

Science Conference Proceedings (OSTI)

An Earth outgoing longwave radiation (OLWR) climate model was constructed for radiation budget studies. The model consists of the upward radiative transfer parameterization of Thompson and Warren, the cloud cover model of Sherr et al., and a ...

Shi-Keng Yang; G. Louis Smith; Fred L. Bartman

1988-10-01T23:59:59.000Z

312

Aerial radiation survey at a military range.  

SciTech Connect

Aberdeen Proving Ground (APG) is currently listed on the Superfund National Priorities List because of past waste handling practices at 13 'study areas.' Concern has been expressed that anthropogenic radioisotopes may have been released at some of the study areas, with the potential of posing health risks to human or ecological receptors. This concern was addressed by thoroughly searching archival records, sampling and analyzing environmental media, and performing an aerial radiation survey. The aerial radiation survey techniques employed have been used over all U.S. Department of Energy and commercial reactor sites. Use of the Aerial Measurement System (AMS) allowed investigators to safely survey areas where surveys using hand-held instruments would be difficult to perform. In addition, the AMS delivered a full spectrum of the measured gamma radiation, thereby providing a means of determining which radioisotopes were present at the surface. As a quality check on the aerial measurements, four ground truth measurements were made at selected locations and compared with the aerial data for the same locations. The results of the survey revealed no evidence of surface radioactive contamination. The measured background radiation, including the cosmic contribution, ranged from 4 to 11 {mu}R/h.

Williams, G. P.; Martino, L. E.; Wrobel, J.; Environmental Assessment; U.S. Army Aberdeen Proving Ground

2001-04-01T23:59:59.000Z

313

IN-SITU PROBING OF RADIATION-INDUCED PROCESSING OF ORGANICS IN ASTROPHYSICAL ICE ANALOGS-NOVEL LASER DESORPTION LASER IONIZATION TIME-OF-FLIGHT MASS SPECTROSCOPIC STUDIES  

Science Conference Proceedings (OSTI)

Understanding the evolution of organic molecules in ice grains in the interstellar medium (ISM) under cosmic rays, stellar radiation, and local electrons and ions is critical to our understanding of the connection between ISM and solar systems. Our study is aimed at reaching this goal of looking directly into radiation-induced processing in these ice grains. We developed a two-color laser-desorption laser-ionization time-of-flight mass spectroscopic method (2C-MALDI-TOF), similar to matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectroscopy. Results presented here with polycyclic aromatic hydrocarbon (PAH) probe molecules embedded in water-ice at 5 K show for the first time that hydrogenation and oxygenation are the primary chemical reactions that occur in astrophysical ice analogs when subjected to Ly{alpha} radiation. We found that hydrogenation can occur over several unsaturated bonds and the product distribution corresponds to their stabilities. Multiple hydrogenation efficiency is found to be higher at higher temperatures (100 K) compared to 5 K-close to the interstellar ice temperatures. Hydroxylation is shown to have similar efficiencies at 5 K or 100 K, indicating that addition of O atoms or OH radicals to pre-ionized PAHs is a barrierless process. These studies-the first glimpses into interstellar ice chemistry through analog studies-show that once accreted onto ice grains PAHs lose their PAH spectroscopic signatures through radiation chemistry, which could be one of the reason for the lack of PAH detection in interstellar ice grains, particularly the outer regions of cold, dense clouds or the upper molecular layers of protoplanetary disks.

Gudipati, Murthy S.; Yang Rui, E-mail: gudipati@jpl.nasa.gov, E-mail: ryang73@ustc.edu [University of Maryland (United States)

2012-09-01T23:59:59.000Z

314

In situ atomic layer deposition and synchrotron-radiation photoemission study of Al2O3 on pristine n-GaAs(0 0 1)-46 surface  

Science Conference Proceedings (OSTI)

This work presents the in situ reflection high-energy electron diffraction (RHEED), scanning tunneling microscopy (STM) and synchrotron-radiation photoemission studies for the morphological and interfacial chemical characterization of in situ atomic ... Keywords: Atomic layer deposition, GaAs, Molecular beam epitaxy, Synchrotron-radiation photoemission

Y. H. Chang; M. L. Huang; P. Chang; J. Y. Shen; B. R. Chen; C. L. Hsu; T. W. Pi; M. Hong; J. Kwo

2011-07-01T23:59:59.000Z

315

The Effects of Radiation on Development of Prostate Cancer and Prostatic  

NLE Websites -- All DOE Office Websites (Extended Search)

Effects of Radiation on Development of Prostate Cancer and Prostatic Effects of Radiation on Development of Prostate Cancer and Prostatic Hyperplasia in Canine Model Gayle Woloschak Northwestern University Abstract Purpose/Objective(s): There have been few studies analyzing radiation-induced prostate cancer in humans or animals. Our research attempts to fill this void by determining the effects of cobalt-60 gamma radiation on the incidence of prostate cancer and prostatic hyperplasia in a large cohort of beagle dogs. Material/Methods: The subjects for the experiment were beagle dogs, which were chosen due to physiologic and anatomic similarities to humans (Thompson, 1989). We retrospectively analyzed data from historic irradiation experiments conducted at Argonne National Laboratory on 347 beagles. The cobalt-60 cohort consisted of 268 dogs, which received whole

316

Definition of Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of...

317

How to Detect Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

How to Detect Radiation How to Survey Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Detection How...

318

Real-time Molecular Study of Bystander Effects of Low dose Low LET radiation Using Living Cell Imaging and Nanoparticale Optics  

SciTech Connect

In this study two novel approaches are proposed to investigate precisely the low dose low LET radiation damage and its effect on bystander cells in real time. First, a flow shear model system, which would provide us a near in vivo situation where endothelial cells in the presence of extra cellular matrix experiencing continuous flow shear stress, will be used. Endothelial cells on matri-gel (simulated extra cellular matrix) will be subjected to physiological flow shear (that occurs in normal blood vessels). Second, a unique tool (Single nano particle/single live cell/single molecule microscopy and spectroscopy; Figure A) will be used to track the molecular trafficking by single live cell imaging. Single molecule chemical microscopy allows one to single out and study rare events that otherwise might be lost in assembled average measurement, and monitor many target single molecules simultaneously in real-time. Multi color single novel metal nanoparticle probes allow one to prepare multicolor probes (Figure B) to monitor many single components (events) simultaneously and perform multi-complex analysis in real-time. These nano-particles resist to photo bleaching and hence serve as probes for unlimited timeframe of analysis. Single live cell microscopy allows one to image many single cells simultaneously in real-time. With the combination of these unique tools, we will be able to study under near-physiological conditions the cellular and sub-cellular responses (even subtle changes at one molecule level) to low and very low doses of low LET radiation in real time (milli-second or nano-second) at sub-10 nanometer spatial resolution. This would allow us to precisely identify, at least in part, the molecular mediators that are responsible of radiation damage in the irradiated cells and the mediators that are responsible for initiating the signaling in the neighboring cells. Endothelial cells subjected to flow shear (2 dynes/cm2 or 16 dynes/cm2) and exposed to 0.1, 1 and 10 cGy on coverslips will be examined for (a) low LET radiation-induced alterations of cellular function and its physiological relevance in real time; and (b) radiation damage triggered bystander effect on the neighboring unirradiated cells. First, to determine the low LET radiation induced alteration of cellular function we will examine: (i) the real time transformation of single membrane transporters in single living cells; (ii) the pump efficiency of membrane efflux pump of live cells in real time at the molecular level; (iii) the kinetics of single-ligand receptor interaction on single live cell surface (Figure C); and (iv) alteration in chromosome replication in living cell. Second, to study the radiation triggered bystander responses, we will examine one of the key signaling pathway i.e. TNF- alpha/NF-kappa B mediated signaling. TNF-alpha specific nano particle sensors (green) will be developed to detect the releasing dynamics, transport mechanisms and ligand-receptor binding on live cell surface in real time. A second sensor (blue) will be developed to simultaneously monitor the track of NF-kB inside the cell. The proposed nano-particle optics approach would complement our DOE funded study on biochemical mechanisms of TNF-alpha- NF-kappa B-mediated bystander effect.

Natarajan, Mohan [UT Health Science Center at San Antonio; Xu, Nancy R [Old Dominion University; Mohan, Sumathy [UT Health Science Center at San Antonio

2013-06-03T23:59:59.000Z

319

A study on the human ability to detect soot deposition onto works of art  

SciTech Connect

Works of art can become soiled due to the deposition of airborne black soot particles within museums and art galleries. The soot particle deposition rates are already known for many environments, but knowing the levels of carbon particle coverage at which humans can detect image darkening is also important. Therefore, in this work, human subjects have been tested to determine their ability to detect soiling by black carbon particles deposited onto specially prepared samples having colored backgrounds. The results show that certain observers are able to detect that a sample is becoming soiled once surface coverage by black carbon particles has reached 2.4% if the soiled samples and clean samples are placed directly adjacent to each other, producing a sharp dividing line (an ``edge-to-edge'' comparison). Observers can detect the presence of soiling with greater than 90% accuracy during an edge-to-edge comparison on most backgrounds when soiling levels reach approximately 3.6% surface coverage by black particles. If the comparison between soiled and clean samples must be made with samples that are separated from each other by a neutral gray area, soiling is only detected with 100% accuracy once coverage by black particles has reached 12.0% surface coverage. These results show that a greater accumulation of black carbon than was previously thought is required to produce a visibly soiled surface.

Bellan, L.M.; Salmon, L.G.; Cass, G.R.

2000-05-15T23:59:59.000Z

320

Radiation dosimeter  

DOE Patents (OSTI)

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even though the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, Richard J. (Oak Ridge, TN)

1983-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Radiation dosimeter  

DOE Patents (OSTI)

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even through the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, R.J.

1981-09-01T23:59:59.000Z

322

Radiation Hydrodynamics  

DOE Green Energy (OSTI)

The discipline of radiation hydrodynamics is the branch of hydrodynamics in which the moving fluid absorbs and emits electromagnetic radiation, and in so doing modifies its dynamical behavior. That is, the net gain or loss of energy by parcels of the fluid material through absorption or emission of radiation are sufficient to change the pressure of the material, and therefore change its motion; alternatively, the net momentum exchange between radiation and matter may alter the motion of the matter directly. Ignoring the radiation contributions to energy and momentum will give a wrong prediction of the hydrodynamic motion when the correct description is radiation hydrodynamics. Of course, there are circumstances when a large quantity of radiation is present, yet can be ignored without causing the model to be in error. This happens when radiation from an exterior source streams through the problem, but the latter is so transparent that the energy and momentum coupling is negligible. Everything we say about radiation hydrodynamics applies equally well to neutrinos and photons (apart from the Einstein relations, specific to bosons), but in almost every area of astrophysics neutrino hydrodynamics is ignored, simply because the systems are exceedingly transparent to neutrinos, even though the energy flux in neutrinos may be substantial. Another place where we can do ''radiation hydrodynamics'' without using any sophisticated theory is deep within stars or other bodies, where the material is so opaque to the radiation that the mean free path of photons is entirely negligible compared with the size of the system, the distance over which any fluid quantity varies, and so on. In this case we can suppose that the radiation is in equilibrium with the matter locally, and its energy, pressure and momentum can be lumped in with those of the rest of the fluid. That is, it is no more necessary to distinguish photons from atoms, nuclei and electrons, than it is to distinguish hydrogen atoms from helium atoms, for instance. There are all just components of a mixed fluid in this case. So why do we have a special subject called ''radiation hydrodynamics'', when photons are just one of the many kinds of particles that comprise our fluid? The reason is that photons couple rather weakly to the atoms, ions and electrons, much more weakly than those particles couple with each other. Nor is the matter-radiation coupling negligible in many problems, since the star or nebula may be millions of mean free paths in extent. Radiation hydrodynamics exists as a discipline to treat those problems for which the energy and momentum coupling terms between matter and radiation are important, and for which, since the photon mean free path is neither extremely large nor extremely small compared with the size of the system, the radiation field is not very easy to calculate. In the theoretical development of this subject, many of the relations are presented in a form that is described as approximate, and perhaps accurate only to order of {nu}/c. This makes the discussion cumbersome. Why are we required to do this? It is because we are using Newtonian mechanics to treat our fluid, yet its photon component is intrinsically relativistic; the particles travel at the speed of light. There is a perfectly consistent relativistic kinetic theory, and a corresponding relativistic theory of fluid mechanics, which is perfectly suited to describing the photon gas. But it is cumbersome to use this for the fluid in general, and we prefer to avoid it for cases in which the flow velocity satisfies {nu} << c. The price we pay is to spend extra effort making sure that the source-sink terms relating to our relativistic gas component are included in the equations of motion in a form that preserves overall conservation of energy and momentum, something that would be automatic if the relativistic equations were used throughout.

Castor, J I

2003-10-16T23:59:59.000Z

323

Origins and consequences of radiation–induced centrosome aberrations  

NLE Websites -- All DOE Office Websites (Extended Search)

Origins and consequences of radiation–induced centrosome aberrations Origins and consequences of radiation–induced centrosome aberrations Sangeetha Vijayakumar New York University School of Medicine Abstract Centrosome aberrations are frequently observed in pre-neoplastic breast lesions and are known to drive chromosomal instability (Lingle et al., 2002). Previous studies from our lab have shown that human mammary epithelial cells exposed to low doses of radiation exhibit centrosome aberrations (CAs) in a dose dependent manner from 10-200 cGy (Maxwell et al., 2008). These data demonstrated that radiation-induced CAs actually precede and generate genomic instability and that TGFβ is a key mediator of genomic surveillance by eliminating genomically unstable cells through p53-dependent apoptosis. While high dose radiation has been shown to cause centrosome aberrations

324

Low Dose Radiation Research Program: Genomic Instability and...  

NLE Websites -- All DOE Office Websites (Extended Search)

Genomic Instability and Low Dose Low Dose Rate Radiation. Authors: Lei Huang, Suzanne Grim, William F. Morgan Institutions: University of Maryland. Humans will always receive...

325

Low Dose Radiation Research Program: Susan S. Wallace  

NLE Websites -- All DOE Office Websites (Extended Search)

Susan S. Wallace University of Vermont Past Funded Project Free Radical DNA Damage Produced Endogenously and by Low Dose Radiation in Human Cells: Quantitation, Consequences, and...

326

RADIATION DETECTOR  

DOE Patents (OSTI)

A radiation detector of the type is described wherein a condenser is directly connected to the electrodes for the purpose of performing the dual function of a guard ring and to provide capacitance coupling for resetting the detector system.

Wilson, H.N.; Glass, F.M.

1960-05-10T23:59:59.000Z

327

DOE Challenge Home Case Study, Manatee County Habitat for Humanity, Ellenton, FL, Affordable  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Manatee County Manatee County Habitat for Humanity Ellenton, FL BUILDING TECHNOLOGIES OFFICE DOE Challenge Home builders are in the top 1% of builders in the country meeting the extraordinary levels of excellence and quality specifi ed by the U.S. Department of Energy. Every DOE Challenge Home starts with ENERGY STAR for Homes Version 3 for an energy-effi cient home built on a solid foundation of building science research. Then, even more advanced technologies are designed in for a home that goes above and beyond current code to give you the superior quality construction, HVAC, appliances, indoor air quality, safety, durability, comfort, and solar-ready components along with ultra-low or no utility bills. This provides homeowners with a quality home that will last for generations to come.

328

A study of longwave radiation codes for climate studies: Validation with ARM observations and tests in general circulation models. Technical report, 15 September 1990--25 April 1993  

SciTech Connect

This report summarizes the activities of our group to meet our stated objectives. The report is divided into sections entitled: Radiation Model Testing Activities, General Circulation Model Testing Activities, Science Team Activities, and Publications, Presentations and Meetings. The section on Science Team Activities summarizes our participation with the science team to further advance the observation and modeling programs. Appendix A lists graduate students supported, and post-doctoral appointments during the project. Reports on the activities during each of the first two years are included as Appendix B. Significant progress has been made in: determining the ability of line-by-line radiation models to calculate the downward longwave flux at the surface; determining the uncertainties in calculated the downwelling radiance and flux at the surface associated with the use of different proposed profiling techniques; intercomparing clear-sky radiance and flux observations with calculations from radiation codes from different climate models; determining the uncertainties associated with estimating N* from surface longwave flux observations; and determining the sensitivity of model calculations to different formulations of the effects of finite sized clouds.

Ellingson, R.G.; Baer, F.

1993-12-31T23:59:59.000Z

329

NIST Radiation thermometry  

Science Conference Proceedings (OSTI)

Radiation thermometry. Summary: ... Description: Radiation thermometers are calibrated using a range of variable-temperature blackbodies. ...

2011-10-13T23:59:59.000Z

330

NIST Optical Radiation Group  

Science Conference Proceedings (OSTI)

Optical Radiation Group. Welcome. The Optical Radiation Group maintains, improves, and disseminates the national scales ...

2013-07-29T23:59:59.000Z

331

Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Ancient Salt Beds Ancient Salt Beds Repository Science Renewable Energy The WIPP Underground may be ideal to study effects of Very Low Dose Rates on Biological Systems Low Background Radiation Experiment We're all bathing in it. It's in the food we eat, the water we drink, the soil we tread and even the air we breathe. It's background radiation, it's everywhere and we can't get away from it. But what would happen if you somehow "pulled the plug" on natural background radiation? Would organisms suffer or thrive if they grew up without their constant exposure to background radiation? That's what a consortium of scientists conducting an experiment at the Waste Isolation Pilot Plant aim to find out. Despite being an underground repository for transuranic radioactive waste,

332

A study of signal generation and charge collection in a-Si:H diodes for radiation imaging  

SciTech Connect

Its high radiation resistivity and large-area capability are the expected advantages of this material together with its ability to provide a front-end readout electronics in the vicinity of the sensor element. Electrons and holes created by incoming charged particles, X-rays, {gamma} rays, are drifted by the electric field inside a-Si:H diodes and this carrier movement induces signal charges on electrodes. Charge collection and signal generation process are analyzed in terms of carrier mobilities, lifetimes and electric field. Charge collection in thick a-Si:H diodes is often limited by deep-level trapping of carriers during transit and a finite charge integration time required for single particle counting in some applications and sometimes by volume recombination of carriers for detecting heavily-ionizing particles such as {alpha} particles. The charge collection process is also strongly affected by the non-uniform electric field profiles in a-Si:H diodes caused by the fixed space charges inside the material under reverse-bias. Signal generation due to a weak light pulse irradiating each end of a thick diode is measured as a function of a reverse-bias and it gives a valuable information about the fixed space charges. Field profiles can be manipulated by either doping, electrode geometry, or combination of both to improve the charge collection process. One can apply a higher reverse-bias on a diode with an equivalent thickness by providing buffer layers at each end of the diode and thus suppressing soft breakdown phenomena. X-ray detection with a good sensitivity is demonstrated by an a-Si:H photodiode coupled to an evaporated CsI scintillator. The scintillation quality of evaporated CsI layers can be made almost identical to its single crystal counterpart. Fields of a-Si:H radiation detector application include high energy physics, medical imaging, materials science and life science. 78 refs., 68 figs., 11 tabs.

Fujieda, I.

1990-10-01T23:59:59.000Z

333

Using nitrogen-14 nuclear quadrupole resonance and electric field gradient information for the study of radiation effects  

Science Conference Proceedings (OSTI)

Nitrogen-14 nuclear quadrupole resonance (NQR) was used in an attempt to detect the effects of ionizing radiation on organic material. Previously reported resonances for urea were detected at 2,913.32 {+-} 0.01 kHz and 2,347.88 {+-} 0.08 kHz with associated T{sub 2}* values 780 {+-} 20 {micro}s and 523 {+-} 24 {micro}s, respectively. The previously unreported {nu}{sub {minus}} line for urea-d{sup 4} was detected at 2,381 {+-} 0.04 Khz and used to determine accurately for the first time the values for the nuclear quadrupole coupling constant {chi} (3,548.74 {+-} 0.03 kHz) and the asymmetry parameter {eta} (0.31571 {+-} 0.00007) for urea-d{sup 4}. The inverse linewidth parameter T{sub 2}* for {nu}{sub +} was measured at 928 {+-} 23 {micro}s and for {nu}{sub {minus}} at 721 {+-} 12 {micro}s. Townes and Dailey analysis was performed and urea-d{sup 4} exhibits a 0.004 increase in lone pair electronic density and a slight decrease in N-H bond electronic density, as compared to urea, probably due to the mass difference. A relationship is proposed, referred to as NQR linewidth analysis, between the dynamic spin relaxation times T{sub 2} and T{sub 2}* and the widths of the distributions of the NQR parameters. Linewidth analysis is presented as a tool for possible use in future NQR work in all area, not just radiation effects. This relationship is tested using sodium nitrite T{sub 2} and T{sub 2}* values for {nu}{sub {minus}} and {nu}{sub {minus}} as a function of temperature.

Iselin, L.H.

1995-12-01T23:59:59.000Z

334

Influence of Extraterrestrial Radiation on Radiation Portal Monitors  

Science Conference Proceedings (OSTI)

Cosmic radiation and solar flares can be a major source of background radiation at the Earths surface. This paper examines the relationship between extraterrestrial radiation and the detectable background in radiation portal monitors used for homeland security applications. Background radiation data from 13 radiation portal monitor facilities are examined and compared against external sources of data related to extraterrestrial radiation, including measurements at neutron monitors located at 53 cosmic-ray observatories around the Earth, four polar orbiting satellites, three geostationary satellites, ground-based geomagnetic field data from observatories around the Earth, a solar magnetic index, solar radio flux data, and sunspot activity data. Four-years (January 2003 through December 2006) of data are used in this study, which include the latter part of Solar Cycle 23 as solar activity was on the decline. The analysis shows a significant relationship between some extraterrestrial radiation and the background detected in the radiation portal monitors. A demonstrable decline is shown in the average gamma ray and neutron background at the radiation portal monitors as solar activity declined over the period of the study.

Keller, Paul E.; Kouzes, Richard T.

2009-06-01T23:59:59.000Z

335

RADIATION SAFETY POLICY Effective Date: April 4, 2012 Originating Office: Office of the  

E-Print Network (OSTI)

radiation exposure "As Low as Reasonably Achievable" "Internal Radiation Permit" ("IRP") means and the general public from unnecessary or potentially harmful levels of radiation exposure. PURPOSE capable of generating X or Gamma radiation "Radiology" involves external exposure of humans to Radiation

Doedel, Eusebius

336

Future directions in therapy of whole body radiation injury  

Science Conference Proceedings (OSTI)

Clinicians have long known that marked granulocytopenia predisposed patients to bacterial infections either from pathogens or commensal organisms with which an individual usually lives in harmony. Evidence that infection was of major importance derives from several observations: (a) clinical observations of bacterial infection in human beings exposed to atomic bomb radiation in Hiroshima and Nagasaki, in reactor accidents, and in large animals dying from radiation exposure, (b) correlative studies on mortality rate, time of death, and incidence of positive culture in animals, (c) challenge of irradiated animals with normally non-virulent organisms, (d) studies of germ free mice and rats, and (e) studies of the effectiveness of antibiotics in reducing mortality rate. General knowledge and sound experimental data on animals and man clearly demonstrated that the sequelae of pancytopenia (bacterial infection, thrombopenic hemorrhage, and anemia) are the lethal factors. A lot of research was required to demonstrate that there were no mysterious radiations toxins, that hyperheparinemia was not a cause of radiation hemorrhage and that radiation hemorrhage could be prevented by fresh platelet transfusions.

Cronkite, E.P.

1989-01-01T23:59:59.000Z

337

Low Dose Radiation Research Program: Research Highlights - Collateral  

NLE Websites -- All DOE Office Websites (Extended Search)

Collateral Damage Collateral Damage Using targeted irradiation to understand radiation-induced effects in bystander cells chromosomal A typical example of chromosomal instability induction measured by chromosome-type aberrations in primary human lymphocytes at delay time post-irradiation of a fraction of the cell population. Similar types of aberrations were observed in whole irradiated population but were not observed in untreated cells. Munira Kadhim Background: It has long been understood that radiation exposure can influence cellular changes. Studies indicate that even very low doses of high linear energy transfer (LET) alpha-particle irradiation, such as that from environmental radon, can affect cells. Radiation-induced genomic instability can be observed in the progeny of irradiated cells and as a

338

Follow medical processes in the human body, study safe hydro-gen storage in complex metal structures for car design, follow  

E-Print Network (OSTI)

Follow medical processes in the human body, study safe hydro- gen storage in complex metal structures for car design, follow the phase transition of foodstuff to improve their taste, detect plastic

339

Male Fertility and Lipid MetabolismChapter 16 The Effect of Antioxidants on Nicotine and Caffeine InducedChanges in Human Sperm? An in Vitro Study  

Science Conference Proceedings (OSTI)

Male Fertility and Lipid Metabolism Chapter 16 The Effect of Antioxidants on Nicotine and Caffeine InducedChanges in Human Sperm? An in Vitro Study Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press

340

Radiation receiver  

SciTech Connect

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

Hunt, Arlon J. (Oakland, CA)

1983-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Radiation receiver  

DOE Patents (OSTI)

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

Hunt, A.J.

1983-09-13T23:59:59.000Z

342

RADIATION SOURCES  

DOE Patents (OSTI)

A novel long-lived source of gamma radiation especially suitable for calibration purposes is described. The source of gamma radiation is denoted mock iodine131, which comprises a naixture of barium-133 and cesium-137. The barium and cesium are present in a barium-cesium ratio of approximately 5.7/1 to 14/1, uniformly dispersed in an ion exchange resin and a filter surrounding the resin comprised of a material of atomic number below approximately 51, and substantially 0.7 to 0.9 millimeter thick.

Brucer, M.H.

1958-04-15T23:59:59.000Z

343

The association betweeen cancers and low level radiation: An evaluation of the epidemiological evidence at the Hanford Nuclear Weapons Facility  

Science Conference Proceedings (OSTI)

Cancer has traditionally been linked to exposure to high doses of radiation, but there is considerable controversy regarding the carcinogenicity of low doses of ionizing radiation in humans. Over the past 30 years there have been 14 studies conducted on employees at the Hanford nuclear weapons facility to investigate the relationship between exposure to low doses of radiation and mortality due to cancer (1-14). Interest in this issue was originally stimulated by the Atomic Energy Commission (AEC) which was trying to determine whether the linear extrapolation of health effects from high to low dose exposure was accurate. If the risk has been underestimated, then the maximum permissible occupational radiation exposure in the United States had been set too high. Because the health risk associated with low level radiation are unclear and controversial it seems appropriate to review the studies relating to Hanford at this time.

Britton, J. [Univ. of California, Berkeley, CA (United States). School of Public Health]|[Lawrence Berkeley National Lab., CA (United States)

1993-05-01T23:59:59.000Z

344

Medical applications of synchrotron radiation  

SciTech Connect

Ever since the first diagnostic x-ray was done in the United States on February 3, 1896, the application of ionizing radiation to the field of medicine has become increasingly important. Both in clinical medicine and basic research the use of x-rays for diagnostic imaging and radiotherapy is now widespread. Radiography, angiography, CAT and PETT scanning, mammography, and nuclear medicine are all examples of technologies developed to image the human anatomy. In therapeutic applications, both external and internal sources of radiation are applied to the battle against cancer. The development of dedicated synchrotron radiation sources has allowed exciting advances to take place in many of these applications. The new sources provide tunable, high-intensity monochromatic beams over a wide range of energies which can be tailored to specific programmatic needs. This paper surveys those areas of medical research in which synchrotron radiation facilities are actively involved.

Thomlinson, W.

1991-10-01T23:59:59.000Z

345

Medical Applications of Synchrotron Radiation  

DOE R&D Accomplishments (OSTI)

Ever since the first diagnostic x-ray was done in the United States on February 3, 1896, the application of ionizing radiation to the field of medicine has become increasingly important. Both in clinical medicine and basic research the use of x-rays for diagnostic imaging and radiotherapy is now widespread. Radiography, angiography, CAT and PETT scanning, mammography, and nuclear medicine are all examples of technologies developed to image the human anatomy. In therapeutic applications, both external and internal sources of radiation are applied to the battle against cancer. The development of dedicated synchrotron radiation sources has allowed exciting advances to take place in many of these applications. The new sources provide tunable, high-intensity monochromatic beams over a wide range of energies which can be tailored to specific programmatic needs. This paper surveys those areas of medical research in which synchrotron radiation facilities are actively involved.

Thomlinson, W.

1991-10-00T23:59:59.000Z

346

Low Dose Radiation Program: Links - Online Literature  

NLE Websites -- All DOE Office Websites (Extended Search)

Online Literature Online Literature Journals, Books and other Publications Armed Forces Radiobiology Research Institute Chornobyl Center for Nuclear Safety Radioactive Waste and Radioecology "Insight" Magazine Central Research Institute of the Electric Power Industry (CRIEPI) News: Aiming at an information center on low dose radiation research Health Physics International Journal of Radiation Biology Iranian Journal of Radiation Research Journal of Radiological Protection National Council on Radiation Protection and Measurements Radiation Research U.S. Department of Energy (DOE) Information Bridge Reports Animal Cancer Tests and Human Cancer Risk Assessment: A Broad Perspective Effects of Ionizing Radiation: Atomic Bomb Survivors and Their Children (1945-1995) Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR

347

Radiation Protection Act (Pennsylvania)  

Energy.gov (U.S. Department of Energy (DOE))

This Act combines the radiation safety provisions of The Atomic Energy Development and Radiation Control Act and the Environmental Radiation Protection Act, and empowers the Department of...

348

NEW SOURCES OF RADIATION  

E-Print Network (OSTI)

Stanford Synchrotron Radiation Project Report No. 75/07.IBL 79M0733 Fig. 20. Radiation emission pattern by electronsWinick, Stanford Synchrotron Radiation Laboratory. Fig. 21.

Schimmerling, W.

2010-01-01T23:59:59.000Z

349

Radiation-induced angiosarcoma  

E-Print Network (OSTI)

1a Figure 1b Figure 1. Radiation-induced angiosarcoma in afollowing completion of radiation therapy. Figure 2a Figurecell histiocytosis after radiation for breast carcinoma: can

Anzalone, C Lane; Cohen, Philip R; Diwan, Abdul H; Prieto, Victor G

2013-01-01T23:59:59.000Z

350

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivi...  

NLE Websites -- All DOE Office Websites (Extended Search)

Our research utilizes radiation cataract as a model system to study the effects of low-dose ionizing radiation exposure in a complex, highly differentiated tissue. We believe...

351

The study of human mutation rates. Progress report, 1989--1992  

Science Conference Proceedings (OSTI)

We will describe recent developments regarding the question of induced mutations in the survivors of the atomic bombings of Hiroshima and Nagasaki. As part of that work we, describe some developments with respect to the Amerindian blood samples collected under DoE sponsorship between 1964 and 1982. Then developments regarding the application of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) to the study of genetic variation and mutation affecting protein characteristics. In particular, we will report on the identification and isolation of genes of especial interest as reflected in the behavior of the proteins which they encode.

Neel, J.V.

1992-12-01T23:59:59.000Z

352

Radiative QCD corrections a personal outlook  

E-Print Network (OSTI)

We describe several problems related to the studies of the effects of radiative QCD corrections in the phenomenological and theoretical considerations thus summarizing the work of the QCD part of the Symposium on "Radiative Corrections: Status and Outlook".

Kataev, A L

1994-01-01T23:59:59.000Z

353

Radiative QCD Corrections: A Personal Outlook  

E-Print Network (OSTI)

We describe several problems related to the studies of the effects of radiative QCD corrections in the phenomenological and theoretical considerations thus summarizing the work of the QCD part of the Symposium on "Radiative Corrections: Status and Outlook".

Andrei L. Kataev

1994-10-18T23:59:59.000Z

354

Radiation Budget of the Tropical Intraseasonal Oscillation  

Science Conference Proceedings (OSTI)

This study examines the relationship between precipitation and radiative heating on intraseasonal time scales in the Tropics using collocated top-of-atmosphere (TOA) and surface radiative flux measurements from special field program data [...

Jia-Lin Lin; Brian E. Mapes

2004-08-01T23:59:59.000Z

355

Climatological Aspects of Radiation Fog Occurrence at Albany, New York  

Science Conference Proceedings (OSTI)

We present a detailed investigation of the local radiation fog climatology, carried out in support of our ongoing field program to study radiation fog mechanisms at Albany, New York. At Albany, a distinct radiation fog season is observed during ...

Michael B. Meyer; G. Garland Lala

1990-05-01T23:59:59.000Z

356

Radiation properties of cavity Cerenkov radiation  

SciTech Connect

Cerenkov radiation from cavities has been analyzed by quantum electrodynamic theory. Analytical expressions of basic radiation properties such as the Einstein's A and B coefficients are derived and shown to be directly modified by the cavities. The analysis leads to the conclusion that the coherent radiation from the Cerenkov radiation devices is due to super radiance of spontaneous emission instead of stimulated emission. Coherent and incoherent radiations are analyzed in the THz radiation range.

Gao Ju; Shen Fang [Electrical and Computer Engineering Department, University of Illinois, Urbana, Illinois 61801 (United States)

2006-04-15T23:59:59.000Z

357

256 Los Alamos Science Number 23 1995 Tracer Studies at Los Alamos  

E-Print Network (OSTI)

- os was the danger of internal exposure of workers to the ra- dioactive materials that would Number 23 concerns about the ethics and conduct of human radiation experiments that were performed under the auspices in radiation studies including previously classified docu- ments if possible. A team of experts at the Los

Massey, Thomas N.

358

Travel for the 2004 American Statistical Association Biannual Radiation Meeting: "Radiation in Realistic Environments: Interactions Between Radiation and Other Factors  

SciTech Connect

The 16th ASA Conference on Radiation and Health, held June 27-30, 2004 in Beaver Creek, CO, offered a unique forum for discussing research related to the effects of radiation exposures on human health in a multidisciplinary setting. The Conference furnishes investigators in health related disciplines the opportunity to learn about new quantitative approaches to their problems and furnishes statisticians the opportunity to learn about new applications for their discipline. The Conference was attended by about 60 scientists including statisticians, epidemiologists, biologists and physicists interested in radiation research. For the first time, ten recipients of Young Investigator Awards participated in the conference. The Conference began with a debate on the question: Do radiation doses below 1 cGy increase cancer risks? The keynote speaker was Dr. Martin Lavin, who gave a banquet presentation on the timely topic How important is ATM? The focus of the 2004 Conference on Radiation and Health was Radiation in Realistic Environments: Interactions Between Radiation and Other Risk Modifiers. The sessions of the conference included: Radiation, Smoking, and Lung Cancer Interactions of Radiation with Genetic Factors: ATM Radiation, Genetics, and Epigenetics Radiotherapeutic Interactions The Conference on Radiation and Health is held bi-annually, and participants are looking forward to the 17th conference to be held in 2006.

Brenner, David J.

2009-07-21T23:59:59.000Z

359

Effects of a 60 Hz Magnetic Field of up to 50 mT on Human Neuromotor Control: An EEG/EMG/Tremor Study  

Science Conference Proceedings (OSTI)

High voltage power lines, industrial processes, and domestic electric appliances are among the numerous sources of daily exposure to extremely low frequency (ELF, below 300 Hz) magnetic fields (MF). ELF MF effects on humans have been studied over the past few decades, and these fields have been reported to affect human movement, brain electrical activity, and high-level brain information processing (cognition). Different strategies have been used to tackle this question using various physiological, ...

2013-11-25T23:59:59.000Z

360

United States Transuranium and Uranium Registries: Researching radiation protection. USTUR annual report for February 1, 1999 through January 31, 2000  

SciTech Connect

The United States Transuranium and Uranium Registries (USTUR) comprise a human tissue research program studying the deposition, biokinetics and dosimetry of the actinide elements in humans with the primary goals of providing data fundamental to the verification, refinement, or future development of radiation protection standards for these and other radionuclides, and of determining possible bioeffects on both a macro and subcellular level attributable to exposure to the actinides. This report covers USTUR activities during the year from February 1999 through January 2000.

Ehrhart, Susan M. (ed.); Filipy, Ronald E. (ed.)

2000-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Triple Ion-Beam Studies of Radiation Damage Effects in a 316LN Austenitic Alloy for a High Power Spallation Neutron Source  

DOE Green Energy (OSTI)

Austenitic 316LN alloy was ion-irradiated using the unique Triple Ion Beam Facility (TIF) at ORNL to investigate radiation damage effects relevant to spallation neutron sources. The TIF was used to simulate significant features of GeV proton irradiation effects in spallation neutron source target materials by producing displacement damage while simultaneously injecting helium and hydrogen at appropriately high gas/dpa ratios. Irradiations were carried out at 80, 200, and 350 C using 3.5 MeV Fe{sup 2}, 360 keV He{sup +}, and 180 keV H{sup +} to accumulate 50 dpa by Fe, 10,000 appm of He, and 50,000 appm of H. Irradiations were also carried out at 200 C in single and dual ion beam modes. The specific ion energies were chosen to maximize the damage and the gas accumulation at a depth of {approx} 1 {micro}m. Variations in microstructure and hardness of irradiated specimens were studied using transmission electron microscopy (TEM) and a nanoindentation technique, respectively. TEM investigation yielded varying damage defect microstructures, comprising black dots, faulted and unfaulted loops, and a high number density of fine bubbles (typically less than 1 nm in diameter). With increasing temperature, faulted loops had a tendency to unfault, and bubble microstructure changed from a bimodal size distribution to a unimodal distribution. Triple ion irradiations at the three temperatures resulted in similar increases in hardness of approximately a factor of two. Individually, Fe and He ions resulted in a similar magnitude of hardness increase, whereas H ions showed only a very small effect. The present study has yielded microstructural information relevant to spallation neutron source conditions and indicates that the most important concern may be radiation induced hardening and associated ductility loss.

Lee, EH

2001-08-01T23:59:59.000Z

362

Types of Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

External Irradiation Contamination Incorporation Biological Effects of Acute, Total Body Irradiation Managing Radiation Emergencies Procedure Demonstration Types of radiation...

363

Radiation Effects In Ceramics  

Science Conference Proceedings (OSTI)

RADIATION MATERIALS SCIENCE IN TECHNOLOGY APPLICATIONS II: Radiation Effects in Ceramics. Sponsored by: Jt. SMD/MSD Nuclear Materials...

364

Ionizing Radiation Dosimetry  

Science Conference Proceedings (OSTI)

Ionizing Radiation Dosimetry. ... OH. US Air Force Radiation Dosimetry Laboratory, Wright-Patterson - Base, OH [100548- 0] PA. ...

2013-09-06T23:59:59.000Z

365

Radiation Physics Division  

Science Conference Proceedings (OSTI)

... The Radiation Physics Division, part of the Physical Measurement Laboratory ... the measurement standards for ionizing radiations and radioactivity ...

2013-09-05T23:59:59.000Z

366

Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ  

NLE Websites -- All DOE Office Websites (Extended Search)

Disrupted epithelial morphogenesis and aberrant lineage Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ I. Fernandez-Garcia and M.H. Barcellos-Hoff Department of Radiation Oncology, New York University School of Medicine, NY. In the present study, we evaluated cell lineage plasticity and its phenotypic effects in the non-malignant human mammary epithelial cell line MCF10A in response to ionizing radiation and TGFβ. We have recently shown that the molecular profiles of mammary tumors and normal mammary gland from irradiated mice are distinct from those arising in unirradiated mice by virtue of enriched stem cell and progenitor markers. Consistent with this, we found that radiation (10-100 cGy) increases the mammary repopulation capacity in a functional and marker assays (Nguyen et al. Cancer Cell

367

The Effects of Low Dose Irradiation on Inflammatory Response Proteins in a 3D Reconstituted Human Skin Tissue Model  

Science Conference Proceedings (OSTI)

Skin responses to moderate and high doses of ionizing radiation include the induction of DNA repair, apoptosis, and stress response pathways. Additionally, numerous studies indicate that radiation exposure leads to inflammatory responses in skin cells and tissue. However, the inflammatory response of skin tissue to low dose radiation (<10 cGy) is poorly understood. In order to address this, we have utilized a reconstituted human skin tissue model (MatTek EpiDerm FT) and assessed changes in 23 cytokines twenty-four and forty eight hours following treatment of skin with either 3 or 10 cGy low-dose of radiation. Three cytokines, IFN-?, IL-2, MIP-1?, were significantly altered in response to low dose radiation. In contrast, seven cytokines were significantly altered in response to a high radiation dose of 200 cGy (IL-2, IL-10, IL-13, IFN-?, MIP-1?, TNF ?, and VEGF) or the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (G-CSF, GM-CSF, IL-1?, IL-8, MIP-1?, MIP-1?, RANTES). Additionally, radiation induced inflammation appears to have a distinct cytokine response relative to the non-radiation induced stressor, TPA. Overall, these results indicate that there are subtle changes in the inflammatory protein levels following exposure to low dose radiation and this response is a sub-set of what is seen following a high dose in a human skin tissue model.

Varnum, Susan M.; Springer, David L.; Chaffee, Mary E.; Lien, Katie A.; Webb-Robertson, Bobbie-Jo M.; Waters, Katrina M.; Sacksteder, Colette A.

2012-12-01T23:59:59.000Z

368

Biology Studies  

NLE Websites -- All DOE Office Websites (Extended Search)

Studies Radiation biologists study the effect of radiation on living tissue. This field, which has direct analogies to the SEE studies, looks at the damage sustained by cells in...

369

Study of Horizontally Oriented Ice Crystals with CALIPSO Observations and Comparison with Monte Carlo Radiative Transfer Simulations  

E-Print Network (OSTI)

Study of Horizontally Oriented Ice Crystals with CALIPSO Observations and Comparison with Monte oriented ice crystals (HOIC) occur frequently in both ice and mixed-phase clouds. When compared with the case for clouds consisting of randomly oriented ice crystals (ROIC), lidar measurements from clouds

Baum, Bryan A.

370

Human Collagen Injections to Reduce Rectal Dose During Radiotherapy  

Science Conference Proceedings (OSTI)

Objectives: The continuing search for interventions, which address the incidence and grade of rectal toxicities associated with radiation treatment of prostate cancer, is a major concern. We are reporting an investigational trial using human collagen to increase the distance between the prostate and anterior rectal wall, thereby decreasing the radiation dose to the rectum. Methods: This is a pilot study evaluating the use of human collagen as a displacing agent for the rectal wall injected before starting a course of intensity-modulated radiotherapy (IMRT) for prostate cancer. Using a transperineal approach, 20 mL of human collagen was injected into the perirectal space in an outpatient setting. Computerized IMRT plans were performed pre- and postcollagen injection, and after a patient completed their radiotherapy, to determine radiation dose reduction to the rectum associated with the collagen injection. Computed tomography scans were performed 6 months and 12 months after completing their radiotherapy to evaluate absorption rate of the collagen. All patients were treated with IMRT to a dose of 75.6 Gy to the prostate. Results: Eleven patients were enrolled into the study. The injection of human collagen in the outpatient setting was well tolerated. The mean separation between the prostate and anterior rectum was 12.7 mm. The mean reduction in dose to the anterior rectal wall was 50%. All men denied any rectal symptoms during the study. Conclusions: The transperineal injection of human collagen for the purpose of tissue displacement is well tolerated in the outpatient setting. The increased separation between the prostate and rectum resulted in a significant decrease in radiation dose to the rectum while receiving IMRT and was associated with no rectal toxicities.

Noyes, William R., E-mail: noyes@cancercenternd.com [Department of Radiation Oncology, Cancer Center of North Dakota, Grand Forks, ND (United States); Hosford, Charles C. [Department of Medical Statistics, University of North Dakota School of Medicine, Grand Forks, ND (United States); Schultz, Steven E. [Department of Urology, RiverView Health, Grand Forks, ND (United States)

2012-04-01T23:59:59.000Z

371

Environmental effects on composite airframes: A study conducted for the ARM UAV Program (Atmospheric Radiation Measurement Unmanned Aerospace Vehicle)  

SciTech Connect

Composite materials are affected by environments differently than conventional airframe structural materials are. This study identifies the environmental conditions which the composite-airframe ARM UAV may encounter, and discusses the potential degradation processes composite materials may undergo when subjected to those environments. This information is intended to be useful in a follow-on program to develop equipment and procedures to prevent, detect, or otherwise mitigate significant degradation with the ultimate goal of preventing catastrophic aircraft failure.

Noguchi, R.A.

1994-06-01T23:59:59.000Z

372

Synchrotron Ultraviolet Radiation Facility SURF III ...  

Science Conference Proceedings (OSTI)

... Synchrotron Radiation. What is Synchrotron Radiation? Synchrotron radiation ... known. Properties of Synchrotron Radiation. Schwinger ...

373

Low Dose Radiation Research Program: Frequencies of Radiation-Induced  

NLE Websites -- All DOE Office Websites (Extended Search)

Frequencies of Radiation-Induced Chromosome Interchanges and Frequencies of Radiation-Induced Chromosome Interchanges and Randomness of Chromosome Territory Locations Relative to One Another. Authors: RK Sachs,§ MN Cornforth,‡ KM Greulich-Bode,* L Hlatky, and DJ Brenner|| Institutions: §Department of Mathematics, University of California, ‡University of Texas Medical Branch, *Department of Skin Carcinogenesis, German Cancer Research Center DFCI, Harvard Medical School, ||Center for Radiological Research, Columbia University. Leukemogenesis, and perhaps carcinogenesis in general, often involves specific chromosome translocations. Radiation-induced chromosome translocation frequencies are strongly influenced by how close participating chromosomes are to one another in an interphase cell nucleus. We sought to determine whether chromosomes in human peripheral blood

374

Epidemiology of accidental radiation exposures  

Science Conference Proceedings (OSTI)

Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental exposures and the types of studies that are needed. 64 refs., 3 tabs.

Cardis, E. [International Agency for Research on Cancer, Lyon (France)

1996-05-01T23:59:59.000Z

375

Atmospheric Radiation Measurement (ARM) Data from Black Forest Germany for the Convective and Orographically Induced Precipitation Study (COPS)  

DOE Data Explorer (OSTI)

ARM maintains three major, permanent sites for data collection and deploys the ARM Mobile Facility to other sites as determined. In 2007 the ARM Mobile Facility (AMF) operated in the Black Forest region of Germany as part of the Convective and Orographically Induced Precipitation Study (COPS). Scientists studied rainfall resulting from atmospheric uplift (convection) in mountainous terrain, otherwise known as orographic precipitation. This was part of a six -year duration of the German Quantitative Precipitation Forecasting (QPF) Program. See the COPS home at https://www.uni-hohenheim.de/spp-iop/index.htm and the QPF homepage at http://www.meteo.uni-bonn.de/projekte/SPPMeteo/ Information obtained during COPS will not only aid regional weather forecasts to help protect people and land, but will also help scientists determine how clouds affect the climate in complex terrain around the world. Because of its relevance to society, COPS has been endorsed as a Research and Development Project by the World Weather Research Program. This program was established by the World Meteorological Organization to develop improved and cost-effective forecasting techniques, with an emphasis on high-impact weather. [Taken from http://www.arm.gov/sites/amf/blackforest/] A large collection of data plots based on data streams from specific instruments used at Black Forest are available via a link from ARM's Black Forest site information page. Users will be requested to create a password, but the plots and the data files in the ARM Archive are free for viewing and downloading. The URL to go directly to the ARM Archive, bypassing the information pages, is http://www.archive.arm.gov/ The Office of Biological and Environmental Research in DOE's Office of Science is responsible for the ARM Program. The ARM Archive physically resides at the Oak Ridge National Laboratory.

376

Radiation Environment Assimilation Model (DREAM).  

NLE Websites -- All DOE Office Websites (Extended Search)

DREAM tool increases space weather DREAM tool increases space weather predictions April 13, 2012 Predicting space weather improved by new DREAM modeling tool Earth's radiation belts can now be studied with a new modeling tool called Dynamic Radiation Environment Assimilation Model (DREAM). Researchers in LANL's Space Science and Applications (ISR-1) group are developing DREAM and described its current capabilities and applications in an article published in Space Weather, a journal of the American Geophysical Union. - 2 - Space environment and its hazards The space environment poses a number of radiation hazards to space systems and their occupants. Relativistic electrons, the dominant source of the radiation dose to spacecraft traveling in the outer radiation belts (3-7 Earth radii), have an electron flux

377

The Value of Botox-A in Acute Radiation Proctitis: Results From a Phase I/II Study Using a Three-Dimensional Scoring System  

Science Conference Proceedings (OSTI)

Purpose: Acute radiation proctitis (ARP) is a common side effect of pelvic radiotherapy, and its management is challenging in daily practice. The present phase I/II study evaluates the safety and efficacy of the botulinum toxin A (BTX-A) in ARP treatment for rectal cancer patients undergoing neoadjuvant high-dose-rate endorectal brachytherapy (HDREBT). Methods and Materials: Fifteen patients, treated with neoadjuvant HDREBT, 26-Gy in 4 fractions, received the study treatment that consisted of a single injection of BTX-A into the rectal wall. The injection was performed post-HDREBT and prior to the development of ARP. The control group, 20 such patients, did not receive the BTX-A injection. Both groups had access to standard treatment with hydrocortisone rectal aerosol foam (Cortifoam) and anti-inflammatory and narcotic medication. The ARP was clinically evaluated by self-administered daily questionnaires using visual analog scores to document frequency and urgency of bowel movements, rectal burning/tenesmus, and pain symptoms before and after HDREBT. Results: At the time of this analysis, there was no observed systemic toxicity. Patient compliance with the self-administered questionnaire was 100% from week 1 to 4, 70% during week 5, and 40% during week 6. The maximum tolerated dose was established at the 100-U dose level, and noticeable mean differences were observed in bowel frequency (p = 0.016), urgency (p = 0.007), and pain (p = 0.078). Conclusions: This study confirms the feasibility and efficacy of BTX-A intervention at 100-U dose level for study patients compared to control patients. A phase III study with this dose level is planned to validate these results.

Vuong, Te, E-mail: tvuong@jgh.mcgill.ca [Department of Radiation Oncology, McGill University, Montreal (Canada); Waschke, Kevin [Department of Gastroenterology, McGill University, Montreal (Canada); Niazi, Tamim [Department of Radiation Oncology, McGill University, Montreal (Canada); Richard, Carole [Department of Colorectal Surgery, Universite de Montreal, Montreal (Canada); Parent, Josee [Department of Gastroenterology, McGill University, Montreal (Canada); Liberman, Sender [Department of Colorectal Surgery, McGill University, Montreal (Canada); Mayrand, Serge [Department of Radiation Oncology, McGill University, Montreal (Canada); Loungnarath, Rasmy [Department of Colorectal Surgery, Universite de Montreal, Montreal (Canada); Stein, Barry [Department of Colorectal Surgery, McGill University, Montreal (Canada); Devic, Slobodan [Department of Medical Physics, McGill University, Montreal (Canada)

2011-08-01T23:59:59.000Z

378

Ghost Imaging with Blackbody Radiation  

E-Print Network (OSTI)

We present a theoretical study of ghost imaging by using blackbody radiation source. A Gaussian thin lens equation for the ghost imaging, which depends on both paths, is derived. The dependences of the visibility and quality of the image on the transverse size and temperature of the blackbody are studied. The main differences between the ghost imaging by using the blackbody radiation and by using the entangled photon pairs are image-forming equation, and the visibility and quality of the image

Yangjian Cai; Shiyao Zhu

2004-07-29T23:59:59.000Z

379

Structural studies of the SARS virus Nsp15 endonuclease and the human innate immunity receptor TLR3  

E-Print Network (OSTI)

Three-dimensional (3D) structural determination of biological macromolecules is not only critical to understanding their mechanisms, but also has practical applications. Combining the high resolution imaging of transmission electron microscopy (TEM) and efficient computer processing, protein structures in solution or in two-dimensional (2D) crystals can be determined. The lipid monolayer technique uses the high affinity binding of 6His-tagged proteins to a Ni-nitrilotriacetic (NTA) lipid to create high local protein concentrations, which facilitates 2D crystal formation. In this study, several proteins have been crystallized using this technique, including the SARS virus Nsp15 endonuclease and the human Toll-like receptor (TLR) 3 extracellular domain (ECD). Single particle analysis can determine protein structures in solution without the need for crystals. 3D structures of several protein complexes had been solved by the single particle method, including IniA from Mycobacterium tuberculosis, Nsp15 and TLR3 ECD. Determining the structures of these proteins is an important step toward understanding pathogenic microbes and our immune system.

Sun, Jingchuan

2005-05-01T23:59:59.000Z

380

Estimation of Daytime Net Radiation from Shortwave Radiation Measurements and Meteorological Observations  

Science Conference Proceedings (OSTI)

Changes in surface net radiation Rn control the earths climate, the hydrological cycle, and plant photosynthesis. However, Rn is not readily available. This study develops a method to estimate surface daytime Rn from solar shortwave radiation ...

Kaicun Wang; Shunlin Liang

2009-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

RADIATION COUNTER  

DOE Patents (OSTI)

This patent relates to a radiation counter, and more particularly, to a scintillation counter having high uniform sensitivity over a wide area and capable of measuring alpha, beta, and gamma contamination over wide energy ranges, for use in quickly checking the contami-nation of personnel. Several photomultiplier tubes are disposed in parallel relationship with a light tight housing behind a wall of scintillation material. Mounted within the housing with the photomultipliers are circuit means for producing an audible sound for each pulse detected, and a range selector developing a voltage proportional to the repetition rate of the detected pulses and automatically altering its time constant when the voltage reaches a predetermined value, so that manual range adjustment of associated metering means is not required.

Goldsworthy, W.W.

1958-02-01T23:59:59.000Z

382

RADIATION DOSIMETER  

DOE Patents (OSTI)

An improvement was made in the determination of amounts of ionizing radiation, particularly low-energy beta particles of less than 1000 rad total dose by means of fluid-phase dosimeter employing a stabilized-- sensitized ferrous-ferric colorimetric system in a sulphuric acid medium. The improvement in the dosimeter consists of adding to the ferrous-ferric system in concentrations of 10/sub -2/ to 10/sup -4/M an organic compound having one or more carboxylic or equivalent groups, such compounds being capable of chelating or complexing the iron ions in the solution. Suitable sensitizing and stabilizing agents are benzoic, phthalic, salicylic, malonic, lactic, maleic, oxalic, citric, succinic, phenolic tartaric, acetic, and adipic acid, as well as other compounds which are added to the solution alone or in certain combinations. As in conventional fluid-phase dosimeters, the absorbed dosage is correlated with a corresponding change in optical density at particular wavelengths of the solution.

Balkwell, W.R. Jr.; Adams, G.D. Jr.

1960-05-10T23:59:59.000Z

383

Low Dose Radiation Program: Workshop VI Abstracts  

NLE Websites -- All DOE Office Websites (Extended Search)

Workshop VI Principal Investigator and Abstracts Workshop VI Principal Investigator and Abstracts Anderson, Carl Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Averbeck, Dietrich Cellular Responses at Low Doses of Ionizing Radiation. Azzam, Edouard Adaptive Responses to Low Dose/Low Dose-Rate ?-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism. Bailey, Susan The Role of Telomere Dysfunction in Driving Genomic Instability. Balajee, Adayabalam Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System. Barcellos-Hoff, Mary Helen Imaging Bioinformatics for Mapping Multidimensional Responses. Barcellos-Hoff, Mary Helen Biological Response to Radiation Mediated through the Microenvironment and

384

A review of ground-based heavy-ion radiobiology relevant to space radiation risk assessment: Part II. Cardiovascular and immunological effects  

Science Conference Proceedings (OSTI)

The future of manned space flight depends on an analysis of the numerous potential risks of travel into deep space. Currently no radiation dose limits have been established for these exploratory missions. To set these standards more information is needed about potential acute and late effects on human physiology from appropriate radiation exposure scenarios, including pertinent radiation types and dose rates. Cancer risks have long been considered the most serious late effect from chronic daily relatively low-dose exposures to the complex space radiation environment. However, other late effects from space radiation exposure scenarios are under study in ground-based accelerator facilities and have revealed some unique particle radiation effects not observed with conventional radiations. A comprehensive review of pertinent literature that considers tissue effects of radiation leading to functional detriments in specific organ systems has recently been published (NCRP National Council on Radiation Protection and Measurements, Information Needed to Make Radiation Protection Recommendations for Space Missions Beyond Low-Earth Orbit, Report 153, Bethesda, MD, 2006). This paper highlights the review of two non-cancer concerns from this report: cardiovascular and immunological effects.

Blakely, Eleanor A.; Chang, Polly Y.

2007-02-26T23:59:59.000Z

385

Institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: A case study  

E-Print Network (OSTI)

and Bolinas in California, and Cape Cod in Massachu- setts.human biomonitoring on Cape Cod. In response to communitydisruptions occurred in the Cape Cod project when we sought

2010-01-01T23:59:59.000Z

386

Gamma Radiation & X-Rays  

NLE Websites -- All DOE Office Websites (Extended Search)

Gamma Radiation and X-Rays 1. Gamma radiation and X-rays are electromagnetic radiation like visible light, radio waves, and ultraviolet light. These electromagnetic radiations...

387

A Study of Cloud-Generated Radiative Heating and Its Generation of Available Potential Energy. Part ii: Results for a Climatological Zonal Mean January  

Science Conference Proceedings (OSTI)

Cloud-generated radiative heating is computed for January zonal mean conditions for low and midclouds. For both cases, the strongest influence was found to be in the low troposphere, with marked differences in signs and magnitudes. Optically thin ...

R. Stuhlmann; G. L. Smith

1988-12-01T23:59:59.000Z

388

The 2728 October 1986 FIRF IFO Cirrus Case Study: Comparison of Radiative Transfer Theory with Observations by Satellite and Aircraft  

Science Conference Proceedings (OSTI)

Observations of cirrus and altocumulus clouds during the First International Satellite Cloud Climatology Project Regional Experiment (FIRE) are compared to theoretical models of cloud radiative properties. Three tests are performed. First, ...

Bruce A. Wielicki; J.T. Suttles; Andrew J. Heymsfield; Ronald M. Welch; James D. Spinhirne; Man-Li C. Wu; David O'C. Starr; Lindsay Parker; Robert F. Arduini

1990-11-01T23:59:59.000Z

389

An Ultralight Aircraft as Platform for Research in the Lower Troposphere: System Performance and First Results from Radiation Transfer Studies in Stratiform Aerosol Layers and Broken Cloud Conditions  

Science Conference Proceedings (OSTI)

The ultraviolet actinic radiation flux governing the photochemical reactions in the atmosphere is dependent on the optical properties of atmospheric aerosols and reflective surfaces of ground and clouds. Theoretical models exist for horizontal ...

Wolfgang Junkermann

2001-06-01T23:59:59.000Z

390

DETECTORS FOR RADIATION DOSIMETRY  

E-Print Network (OSTI)

2) W. J. Price, "Nuclear Radiation Detection" (2nd ed. , Newand R. J. Berry, "Manual on Radiation Dosimetry" (New York:4) G. F. Knoll, "Radiation Detection and Measurement" (New

Perez-Mendez, V.

2010-01-01T23:59:59.000Z

391

Highlights in Radiation Research - A Timeline  

NLE Websites -- All DOE Office Websites (Extended Search)

survivors. 1947 Atomic Bomb Casualty Commission (ABCC) created to study the biological effects of radiation on Japanese atomic bomb survivors. Brookhaven National Laboratory...

392

Low Dose Radiation Program: Principal Program Contacts  

NLE Websites -- All DOE Office Websites (Extended Search)

to the Office of Biological and Environmental Research. Dr. Barcellos-Hoff's current research interests are studies of breast cancer and ionizing radiation. The goal of her...

393

Low Dose Radiation Research Program: Mohan Natarajan  

NLE Websites -- All DOE Office Websites (Extended Search)

of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Funded Project Real-Time Molecular Study of Bystander Effect Using...

394

NIST Ionizing Radiation Division 2000 - Future Directions  

Science Conference Proceedings (OSTI)

... will enable dose-reconstruction studies for populations exposed at the natural background levels of ionizing radiation. Calibrations of Low-Energy ...

395

Atmospheric Radiation Measurement Convective and Orographically...  

NLE Websites -- All DOE Office Websites (Extended Search)

Induced Precipitation Study The U.S. Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility is providing the ARM Mobile Facility...

396

Courses on Synchrotron Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Synchrotron Radiation The following is an incomplete list of courses on Synchrotron Radiation. For additional courses, check lightsources.org. XAFS School The APS XAFS School...

397

Radiation Physics Events  

Science Conference Proceedings (OSTI)

NIST Home > Radiation Physics Events. Radiation Physics Events. (showing 1 - 3 of 3). CIRMS 2012 Start Date: 10/22/2012 ...

2011-12-01T23:59:59.000Z

398

Bayesian Radiation Source Localization  

Science Conference Proceedings (OSTI)

Technical Paper / Special Issue on the 16th Biennial Topical Meeting of the Radiation Protection and Shielding Division / Radiation Measurements and General Instrumentation

Kenneth D. Jarman; Erin A. Miller; Richard S. Wittman; Christopher J. Gesh

399

Radiation Control (Virginia)  

Energy.gov (U.S. Department of Energy (DOE))

The Department of Health is responsible for regulating radiation and radioactive materials in the Commonwealth of Virginia. Although the Department's Radiation Control Program primarily focuses on...

400

Solar radiation resource assessment  

DOE Green Energy (OSTI)

The bulletin discusses the following: introduction; Why is solar radiation resource assessment important Understanding the basics; the solar radiation resource assessment project; and future activities.

Not Available

1990-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Adoption of Preoperative Radiation Therapy for Rectal Cancer From 2000 to 2006: A Surveillance, Epidemiology, and End Results Patterns-of-Care Study  

SciTech Connect

Purpose: The German rectal study determined that preoperative radiation therapy (RT) as a component of combined-modality therapy decreased local tumor recurrence, increased sphincter preservation, and decreased treatment toxicity compared with postoperative RT for rectal cancer. We evaluated the use of preoperative RT after the presentation of the landmark German rectal study results and examined the impact of tumor and sociodemographic factors on receiving preoperative RT. Methods and Materials: In total, 20,982 patients who underwent surgical resection for T3-T4 and/or node-positive rectal adenocarcinoma diagnosed from 2000 through 2006 were identified from the Surveillance, Epidemiology, and End Results tumor registries. We analyzed trends in preoperative RT use before and after publication of the findings from the German rectal study. We also performed multivariate logistic regression to identify factors associated with receiving preoperative RT. Results: Among those treated with RT, the proportion of patients treated with preoperative RT increased from 33.3% in 2000 to 63.8% in 2006. After adjustment for age; gender; race/ethnicity; marital status; Surveillance, Epidemiology, and End Results registry; county-level education; T stage; N stage; tumor size; and tumor grade, there was a significant association between later year of diagnosis and an increase in preoperative RT use (adjusted odds ratio, 1.26/y increase; 95% confidence interval, 1.23-1.29). When we compared the years before and after publication of the German rectal study (2000-2003 vs. 2004-2006), patients were more likely to receive preoperative RT than postoperative RT in 2004-2006 (adjusted odds ratio, 2.35; 95% confidence interval, 2.13-2.59). On multivariate analysis, patients who were older, who were female, and who resided in counties with lower educational levels had significantly decreased odds of receiving preoperative RT. Conclusions: After the publication of the landmark German rectal study, there was widespread, rapid adoption of preoperative RT for locally advanced rectal cancer. However, preoperative RT may be underused in certain sociodemographic groups.

Mak, Raymond H. [Harvard Radiation Oncology Program, Boston, MA (United States); McCarthy, Ellen P. [Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (Israel); Das, Prajnan [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Hong, Theodore S. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Mamon, Harvey J. [Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA (United States); Hoffman, Karen E., E-mail: khoffman1@mdanderson.org [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2011-07-15T23:59:59.000Z

402

Effects of gonadal irradiation in clinical radiation therapy: a review  

SciTech Connect

Recent improvements in radiation therapy of some malignancies in lower abdominal sites are leading to prolongation of life in persons of child-bearing age. These successes require an evaluation of the possible undesirable consequences of the unavoidable gonadal irradiation that occurs in these cases. A review of radiobiological data from experimental animal studies and retrospective clinical studies suggests that in most instances human gonadal exposures in both sexes are insufficient to cause permanent sterility, because the exposures are fractionated and the total gonadal dose is much less than 600 rads. As a consequence, return of fertility must be anticipated, and the worrisome questions of radiation-induced genetic damage in subsequent pregnancies must be addressed. This review did not substantiate this fear, because no case reports could be found of malformed infants among the progency of previously irradiated parents. Some experimental studies suggest that radiation-damaged spermatogonia are self-destructive, but any evidence for this phenomenon in the ovary is nonexistent. We suggest that the difference between fact and theory here may be the mathematical result of the interplay of low probability for occurrences and the few patients who until now have survived long enough for study. (auth)

Lushbaugh, C.C.; Casarett, G.W.

1976-02-01T23:59:59.000Z

403

Geant4 applications in the heliospheric radiation environment  

E-Print Network (OSTI)

The high energy ionizing radiation environment in the solar system consists of three main sources: the radiation belts, galactic cosmic rays and solar energetic particles. Geant4 is a Monte Carlo radiation transport simulation toolkit, with applications in areas as high energy physics, nuclear physics, astrophysics or medical physics research. In this poster, Geant4 applications to model and study the effects of the heliospheric radiation environment are presented. Specific applications are being developed to study the effect of the radiation environment on detector components, to describe the response and to optimise the design of radiation monitors for future space missions and to predict the radiation environment in Mars surface, orbits and moons.

Pedro Brogueira; Patrcia Gonalves; Ana Keating; Dalmiro Maia; Mrio Pimenta; Bernardo Tom

2007-09-11T23:59:59.000Z

404

Human equivalent antenna model for HF exposures: analytical versus numerical approach  

Science Conference Proceedings (OSTI)

In this paper, the human exposure to HF radiation is analyzed using the simplified human equivalent antenna model featuring analytical and numerical approach, respectively. Namely, the human body is represented by an equivalent receiving straight thin ...

Dragan Poljak; Silvestar Sesnic; Ivana Zulim

2009-09-01T23:59:59.000Z

405

Role of ATM kinase in ionizing radiation induced DNA damage response...  

NLE Websites -- All DOE Office Websites (Extended Search)

ATM kinase in ionizing radiation induced DNA damage response in human neural stemprogenitor cells and differentiated cell types Adayabalam Balajee Columbia University Medical...

406

Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22  

SciTech Connect

Purpose: Radiation therapy (RT) is an effective method of palliating painful bone metastases and can improve function and reduce analgesic requirements. In advanced cancer patients, quality of life (QOL) is the primary outcome of interest over traditional endpoints such as survival. The purpose of our study was to compare bone metastasis-specific QOL scores among patients who responded differently to palliative RT. Methods and Materials: Patients receiving RT for bone metastases across 6 countries were prospectively enrolled from March 2010-January 2011 in a trial validating the QLQ-BM22 and completed the QLQ-BM22 and the core measure (QLQ-C30) at baseline and after 1 month. Pain scores and analgesic intake were recorded, and response to RT was determined according to the latest published guidelines. The Kruskal-Wallis nonparametric and Wilcoxon rank sum tests compared changes in QOL among response groups. A Bonferroni-adjusted P<.003 indicated statistical significance. Results: Of 79 patients who received palliative RT, 59 were assessable. Partial response, pain progression, and indeterminate response were observed in 22, 8, and 29 patients, respectively; there were no patients with a complete response. Patients across all groups had similar baseline QOL scores apart from physical functioning (patients who progressed had better initial functioning). One month after RT, patients who responded had significant improvements in 3 of 4 QLQ-BM22 domains (painful site, P<.0001; painful characteristic, P<.0001; and functional interference, P<.0001) and 3 QLQ-C30 domains (physical functioning, P=.0006; role functioning, P=.0026; and pain, P<.0001). Patients with progression in pain had significantly worse functional interference (P=.0007) and pain (P=.0019). Conclusions: Patients who report pain relief after palliative RT also have better QOL with respect to bone metastasis-specific issues. The QLQ-BM22 and QLQ-C30 are able to discriminate among patients with varying responses and are recommended for use in future bone metastasis clinical trials.

Zeng Liang [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Chow, Edward, E-mail: edward.chow@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Bedard, Gillian; Zhang, Liying [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Fairchild, Alysa [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada)] [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Vassiliou, Vassilios [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus)] [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus); Alm El-Din, Mohamed A. [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt)] [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt); Jesus-Garcia, Reynaldo [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil)] [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil); Kumar, Aswin [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India)] [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India); Forges, Fabien [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France) [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France); Unit of Clinical Research, Innovation, and Pharmacology, Saint Etienne University Hospital, Saint-Etienne (France); Tseng, Ling-Ming [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China)] [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China); Hou, Ming-Feng [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China)] [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China); Chie, Wei-Chu [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China)] [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China); Bottomley, Andrew [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)] [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)

2012-11-01T23:59:59.000Z

407

NIST MIRF - Accelerator Radiation Physics  

Science Conference Proceedings (OSTI)

Accelerator Radiation Physics. Medium-energy accelerators are under investigation for production of channeling radiation ...

408

NIST Synchrotron radiation in SSD  

Science Conference Proceedings (OSTI)

Synchrotron radiation in the Sensor Science Division. ... Synchrotron Radiation-Based Calibrations for Space Weather Prediction. ...

2011-10-18T23:59:59.000Z

409

High-let radiation carcinogenesis  

SciTech Connect

Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20 to 30 rads.

Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.; Ullrich, R.L.

1982-01-01T23:59:59.000Z

410

Radiation damage in optical fibers  

SciTech Connect

While plastic-clad-silica (PCS) fiber shows the greatest radiation resistance, PCS fiber has been difficult to reliably connectorize for routine field operations. For this reason, all-glass fibers have been studied as an alternative to PCS. Based on available literature and some preliminary tests at Los Alamos, we have concentrated on fluorosilicate clad, step index, pure silica core fibers. This paper reviews recent laboratory data for these fibers relative to the PCS fibers. This paper also discusses use of a fiber (or any optical medium) on a Cerenkov radiation-to-light transducer. Since the radiation induces attenuation in the medium, the light output is not proportional to the radiation input. The nonlinearity introduced by this attenuation is calculated.

Lyons, P.B.; Looney, L.D.; Ogle, J.W.

1983-01-01T23:59:59.000Z

411

Diffuse solar radiation and associated meteorological  

E-Print Network (OSTI)

Abstract. Solar diffuse radiation data including global radiation, shortwave and longwave balances, net radiation and sunshine hours have been extensively analyzed to study the variation of diffuse radiation with turbidity and cloud discharges appearing in the form of atmospherics over the tropics. Results of surface radiation measurements at Calcutta, Poona, Delhi and Madras are presented together with some meteorological parameters. The monthly values of diffuse radiation and the monthly ratios of diffuse to global solar radiation have been examined, with a special emphasis in relation to the noise level of atmospherics at Calcutta in the very low frequency band. The results exhibit some definite seasonal changes which appear to be in close agreement with one another. 1

unknown authors

1995-01-01T23:59:59.000Z

412

Radiation Detection Instruments  

Science Conference Proceedings (OSTI)

Directory of Accredited Laboratories. Radiation Detection Instruments. In 2005, the Department of Homeland Security requested ...

2013-09-06T23:59:59.000Z

413

Radiation damage considerations  

SciTech Connect

The designs of nuclear fission and fusion power plants do not, in general, appear to make unusual demands on materials in terms of mechanical- property requirements. Radiation environments produce unique effects on the composition, microstructure, and defect population of these alloys, resulting in time-dependent and time-independent changes in mechanical properties. To illustrate these problems, the materials needs of the core of a Liquid-Metal Fast- Breeder Reactor (LMFBR) and of the first wall of a fusion reactor are discussed. In the case of the LMFBR core, the phenomenon of void swelling causes serious design problems, and a search is being made for a low-swelling alloy that has adequate mechanical properties. The fusion reactor poses different problems because the neutron energy is high (14 MeV) and is accompanied by a high flux of charged particles. The long-term choices for a wall material have been narrowed to vanadium and niobium alloys. In the search for low-swelling alloys, it has become clear that minor elements play an important role in determining the nature of the radiation effects. The segregation of minor elements to void surfaces and the dispersion and reformation of second-phase precipitates are two important radiation-induced phenomena that require additional study in view of their influence on void swelling and high-temperature properties. (auth)

Frost, B.R.T.

1975-08-01T23:59:59.000Z

414

Low Dose Radiation Research Program: Howard L. Liber  

NLE Websites -- All DOE Office Websites (Extended Search)

Howard L. Liber Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Currently Funded Projects Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Technical Abstracts 2003 Workshop: Delayed genomic instability in human lymphoblasts exposed to 137Cs y-rays radiation Schwartz, J.L., Jordan, R., Lenarczyk, M. and Liber, H.L. 2002 Workshop: Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Liber, H.L. and Schwartz, J.L. Publications Zhang, Y., Zhou, J., Held, K.D., Redmond, R.W., Prise, K.M., and Liber, H.L. (2008). Deficiencies of double-strand break repair factors and effects on mutagenesis in directly [gamma]-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiation Research 169(2):197-206.

415

Low Dose Radiation Research Program: Kenneth T. Bogen  

NLE Websites -- All DOE Office Websites (Extended Search)

T. Bogen Lawrence Livermore National Laboratory Technical Abstracts 2002 Workshop: Low-dose dose-response of proliferating human cells exposed to low dose rate g-radiation. Enns,...

416

radiation.p65  

Office of Legacy Management (LM)

5 5 United States Department of Energy This fact sheet explains the potential health hazards associated with the radioactive decay of uranium and other radioactive elements found in ore and mill tailings. Potential Health Hazards of Radiation Man-made sources of radiation, most notably from medical uses and consumer products, contribute to the remaining radiation dose that individuals receive. A few household products, including smoke detectors, micro- wave ovens, and color televisions, emit small amounts of radiation. For most people, the benefits from using such products far outweigh the radiation risks. Radiation Dose Radiation is measured in various units. Individuals who have been exposed to radiation have received a radiation dose. Radiation dose to people is expressed in

417

On Hawking radiation of 2d Liouville black hole  

E-Print Network (OSTI)

We adapt the method of complex paths to the study of the radiation of Hawking of Liouville black holes.

Chabab, M; Sedra, M B

2011-01-01T23:59:59.000Z

418

Long-Term Follow-Up of Preoperative Pelvic Radiation Therapy and Concomitant Boost Irradiation in Locally Advanced Rectal Cancer Patients: A Multi-Institutional Phase II Study (KROG 04-01)  

SciTech Connect

Purpose: To perform a prospective phase II study to investigate the efficacy and safety of preoperative pelvic radiation therapy and concomitant small-field boost irradiation with 5-fluorouracil and leucovorin for 5 weeks in locally advanced rectal cancer patients. Methods and Materials: Sixty-nine patients with locally advanced, nonmetastatic, mid-to-lower rectal cancer were prospectively enrolled. They had received preoperative chemoradiation therapy and total mesorectal excision. Pelvic radiation therapy of 43.2 Gy in 24 fractions plus concomitant boost radiation therapy of 7.2 Gy in 12 fractions was delivered to the pelvis and tumor bed for 5 weeks. Two cycles of 5-fluorouracil and leucovorin were administered for 3 days in the first and fifth week of radiation therapy. The pathologic response, survival outcome, and treatment toxicity were evaluated for the study endpoints. Results: Of 69 patients, 8 (11.6%) had a pathologically complete response. Downstaging rates were 40.5% for T classification and 68.1% for N classification. At the median follow-up of 69 months, 36 patients have been followed up for more than 5 years. The 5-year disease-free survival (DFS) and overall survival rates were 66.0% and 75.3%, respectively. Higher pathologic T (P = .045) and N (P = .032) classification were significant adverse prognostic factors for DFS, and high-grade histology was an adverse prognostic factor for both DFS (P = .025) and overall survival (P = .031) on the multivariate analysis. Fifteen patients (21.7%) experienced grade 3 or 4 acute toxicity, and 7 patients (10.1%) had long-term toxicity. Conclusion: Preoperative pelvic radiation therapy with concomitant boost irradiation with 5-fluorouracil and leucovorin for 5 weeks showed acceptable acute and long-term toxicities. However, the benefit of concomitant small-field boost irradiation for 5 weeks in rectal cancer patients was not demonstrated beyond conventional irradiation for 6 weeks in terms of tumor response and survival.

Lee, Jong Hoon [Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul (Korea, Republic of) [Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul (Korea, Republic of); Department of Radiation Oncology, St. Vincent's Hospital, Catholic University of Korea, Suwon (Korea, Republic of); Kim, Dae Yong [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Go-Yang (Korea, Republic of)] [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Go-Yang (Korea, Republic of); Nam, Taek-Keun [Department of Radiation Oncology, Chonnam National University Hospital, Hwa-Sun (Korea, Republic of)] [Department of Radiation Oncology, Chonnam National University Hospital, Hwa-Sun (Korea, Republic of); Yoon, Sei-Chul [Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul (Korea, Republic of)] [Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul (Korea, Republic of); Lee, Doo Seok [Department of Colorectal Surgery, Daehang Hospital, Seoul (Korea, Republic of)] [Department of Colorectal Surgery, Daehang Hospital, Seoul (Korea, Republic of); Park, Ji Won; Oh, Jae Hwan; Chang, Hee Jin [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Go-Yang (Korea, Republic of)] [Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Go-Yang (Korea, Republic of); Yoon, Mee Sun; Jeong, Jae-Uk [Department of Radiation Oncology, Chonnam National University Hospital, Hwa-Sun (Korea, Republic of)] [Department of Radiation Oncology, Chonnam National University Hospital, Hwa-Sun (Korea, Republic of); Jang, Hong Seok, E-mail: hsjang11@catholic.ac.kr [Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul (Korea, Republic of)

2012-11-15T23:59:59.000Z

419

Low Dose Radiation Research Program: Quantitative Analysis of Connexin  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantitative Analysis of Connexin Expression in Cultured Colonies Quantitative Analysis of Connexin Expression in Cultured Colonies Authors: B. Parvin, Q. Yang, R. L. Henshall-Powell and M.H. Barcellos Hoff We are studying the effects of ionizing radiation on the signaling between human mammary epithelial cells and the extracellular microenvironment. To do so we use an assay based on the ability of the cells to organize into three-dimensional acini when embedded into an extracellular matrix. Although tumorigenic and non-tumorigenic mammary epithelial cells are nearly indistinguishable when cultured as monolayers, their biological character readily diverge when tissue-specific morphogenesis is analyzed. Non-malignant human mammary epithelial cells (HMEC) cultured within a reconstituted basement membrane organize into acinar-like structures with

420

Radiation Field Control Manual  

Science Conference Proceedings (OSTI)

The EPRI Radiation Management Program is dedicated to reducing nuclear power plant worker personnel exposure by developing practices and technologies to increase the radiation protection of the worker, and to implement methods to reduce radiation fields. The nuclear power industry has recently implemented the RP2020 Initiative to promote positive radiation protection trends. Control of radiation fields is crucial to one of the initiative goals of reducing exposure. This manual provides the current state ...

2004-12-16T23:59:59.000Z

Note: This page contains sample records for the topic "human radiation studies" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Building America Efficient Solutions for New Homes Case Study: Habitat for Humanity Palm Beach County, West Palm Beach, Florida  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2011, Building America assisted Habitat for Humanity of Palm 2011, Building America assisted Habitat for Humanity of Palm Beach County (HabitatPBC) in completing three high-performance prototype houses that achieved HERS index scores of less than 60, which is about 30% better than typical HabitatPBC construction, at a payback of less than 4 years. The HabitatPBC is planning to implement these strategies in future homes they build. This has the potential for significant and affordable energy savings as HabitatPBC has built more than 111 affordable houses and served an additional 125 families worldwide through their affiliation with HFH International (today serving >20 families a year). Building America (through the Florida Solar Energy Center, a member of the Pacific Northwest National Laboratory team) achieved

422

Cellular response to low dose radiation: Role of phosphatidylinositol-3 kinase like kinases  

Science Conference Proceedings (OSTI)

It is increasingly realized that human exposure either to an acute low dose or multiple chronic low doses of low LET radiation has the potential to cause different types of cancer. Therefore, the central theme of research for DOE and NASA is focused on understanding the molecular mechanisms and pathways responsible for the cellular response to low dose radiation which would not only improve the accuracy of estimating health risks but also help in the development of predictive assays for low dose radiation risks associated with tissue degeneration and cancer. The working hypothesis for this proposal is that the cellular mechanisms in terms of DNA damage signaling, repair and cell cycle checkpoint regulation are different for low and high doses of low LET radiation and that the mode of action of phosphatidylinositol-3 kinase like kinases (PIKK: ATM, ATR and DNA-PK) determines the dose dependent cellular responses. The hypothesis will be tested at two levels: (I) Evaluation of the role of ATM, ATR and DNA-PK in cellular response to low and high doses of low LET radiation in simple in vitro human cell systems and (II) Determination of radiation responses in complex cell microenvironments such as human EpiDerm tissue constructs. Cellular responses to low and high doses of low LET radiation will be assessed from the view points of DNA damage signaling, DNA double strand break repair and cell cycle checkpoint regulation by analyzing the activities (i.e. post-translational modifications and kinetics of protein-protein interactions) of the key target proteins for PI-3 kinase like kinases both at the intra-cellular and molecular levels. The proteins chosen for this proposal are placed under three categories: (I) sensors/initiators include ATM ser1981, ATR, 53BP1, gamma-H2AX, MDC1, MRE11, Rad50 and Nbs1; (II) signal transducers include Chk1, Chk2, FANCD2 and SMC1; and (III) effectors include p53, CDC25A and CDC25C. The primary goal of this proposal is to elucidate the differences in cellular defense mechanisms between low and high doses of low LET radiation and to define the radiation doses where the cellular DNA damage signaling and repair mechanisms tend to shift. This information is critically important to address and advance some of the low dose research program objectives of DOE. The results of this proposed study will lead to a better understanding of the mechanisms for the cellular responses to low and high doses of low LET radiation. Further, systematic analysis of the role of PIKK signaling pathways as a function of radiation dose in tissue microenvironment will provide useful mechanistic information for improving the accuracy of radiation risk assessment for low doses. Knowledge of radiation responses in tissue microenvironment is important for the accurate prediction of ionizing radiation risks associated with cancer and tissue degeneration in humans.

Balajee, A.S.; Meador, J.A.; Su, Y.

2011-03-24T23:59:59.000Z

423

Device for calibrating a radiation detector system  

DOE Patents (OSTI)

A device for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a "shield plate" or shell, and an opposing "source plate" containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, heart, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects.

Mc Fee, Matthew C. (New Ellenton, SC); Kirkham, Tim J. (Beech Island, SC); Johnson, Tippi H. (Aiken, SC)

1994-01-01T23:59:59.000Z

424

Device for calibrating a radiation detector system  

DOE Patents (OSTI)

A device is disclosed for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a ''shield plate'' or shell, and an opposing ''source plate'' containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects. 3 figures.

McFee, M.C.; Kirkham, T.J.; Johnson, T.H.

1994-12-27T23:59:59.000Z

425

Theoretical study of 3-D molecular similarity and ligand binding modes of orthologous human and rat D2 dopamine receptors  

Science Conference Proceedings (OSTI)

The D"2 dopamine receptor (D"2DR) is an important target for the treatment of some central nervous system disorders, such as Parkinson disease, schizophrenia and drug-dependence. In this work, we built 3-D models of the long form of human and rat D"2DRs ... Keywords: 7TM receptor, D2 dopamine receptor ligands, Drug development, Molecular modeling, Parkinson's disease, Rat striatum

Marvin A. Soriano-Ursa; Jorge O. Ocampo-Lpez; Karina Ocampo-Mendoza; Jos G. Trujillo-Ferrara; Jos Correa-Basurto

2011-07-01T23:59:59.000Z

426

Wrong Unit, Train, and Component Events at U.S. Nuclear Power Plants: Joint EPRI-CRIEPI Human Factors Studies  

Science Conference Proceedings (OSTI)

Significant human-related errors can occur when plant personnel perform activities on a wrong unit, train, or component. Such errors can result in costly adverse events such as safety system actuations, technical specification violations, failure of multiple safety trains, and reactor trips. This report investigates the wrong unit, train, component (WUTC) phenomena, providing an assessment of the current state of WUTC events as well as possible interventions for reducing errors.

1995-01-24T23:59:59.000Z

427

Job security and fear: Do these drive our radiation guidelines  

SciTech Connect

This commentary asks why scientists want radiation standard setting at a level well below that at which any health related problem has been observed in a human being. The idea that job security and fear actually may drive radiation standards is presented as a possibility. 3 refs.

Thomas, R.G.

1994-01-01T23:59:59.000Z

428

Study of the temporal and spatial variation of climate and solar radiation in th metropolitan Phoenix area. Final technical progress report, July 1, 1977-June 30, 1978  

DOE Green Energy (OSTI)

The research performed was designed to identify spatial or temporal variation of any atmospheric parameters that might affect the operation of devices utilizing solar energy in the metropolitan Phoenix area. The first part of the research involved the analysis of all available solar and climatic data to determine their validity and comparability. For the standard climatic parameters, few difficulties were encountered, but the task of determining comparability of solar radiation data involved many pitfalls. It was concluded that most of the solar data acquired before January 1977 could not be used for purposes of identifying spatial variability. And, a year and a half of data does not represent a long enough period of time upon which to base sound conclusions about spatial and temporal variability of solar radiation in the metropolitan Phoenix region. The data currently available to u